PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33934954-2	2021	In the current meta-analysis, we attempted to clarify the efficacy of curcumin/turmeric supplementation in reducing concentrations of interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha in patients with an inflammatory background.	Curcumin	70-78	interleukin 6	Homo sapiens	154-158
2556903-4	1989	Generation of O2- radical was inhibited by curcumin, when cells were stimulated by AA, STZ and fmlp.	Curcumin	43-51	formyl peptide receptor 1	Homo sapiens	95-99
2556903-5	1989	Curcumin inhibited the release of myeloperoxidase, an azurophilic granule marker enzyme.	Curcumin	0-8	myeloperoxidase	Homo sapiens	34-49
33979725-3	2021	The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules.	Curcumin	112-120	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-159
33979725-3	2021	The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules.	Curcumin	112-120	acetylcholinesterase (Cartwright blood group)	Homo sapiens	340-344
33979725-3	2021	The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules.	Curcumin	300-308	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-159
33631181-13	2021	Mechanically, curcumin promotes therapeutic angiogenesis by regulating miR-499 mediated PTEN/VEGF/Ang-1 signaling pathway.	Curcumin	14-22	phosphatase and tensin homolog	Mus musculus	88-92
33631181-13	2021	Mechanically, curcumin promotes therapeutic angiogenesis by regulating miR-499 mediated PTEN/VEGF/Ang-1 signaling pathway.	Curcumin	14-22	angiopoietin 1	Mus musculus	98-103
33934954-2	2021	In the current meta-analysis, we attempted to clarify the efficacy of curcumin/turmeric supplementation in reducing concentrations of interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha in patients with an inflammatory background.	Curcumin	70-78	C-X-C motif chemokine ligand 8	Homo sapiens	160-164
33934954-3	2021	The main databases were searched to identify eligible trials evaluating the effect of curcumin in reducing IL-1, IL-6, IL-8, and TNF-alpha in serum up to March 2021.	Curcumin	86-94	interleukin 6	Homo sapiens	113-117
33934954-3	2021	The main databases were searched to identify eligible trials evaluating the effect of curcumin in reducing IL-1, IL-6, IL-8, and TNF-alpha in serum up to March 2021.	Curcumin	86-94	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
33934954-7	2021	Nonetheless, curcumin/turmeric supplementation was non-significantly associated with reduced levels of IL-6 (WMD = -0.33 pg/ml, 95% CI = -0.99-0.34, P = 0.33) and increased levels of IL-8 (WMD = 0.52 pg/ml, 95% CI = -1.13-2.17, P = 0.53).	Curcumin	13-21	interleukin 6	Homo sapiens	103-107
33934954-7	2021	Nonetheless, curcumin/turmeric supplementation was non-significantly associated with reduced levels of IL-6 (WMD = -0.33 pg/ml, 95% CI = -0.99-0.34, P = 0.33) and increased levels of IL-8 (WMD = 0.52 pg/ml, 95% CI = -1.13-2.17, P = 0.53).	Curcumin	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
33934954-8	2021	The dose-responses analysis indicated that curcumin/turmeric supplementation resulted in IL-1 and IL-8 alteration in a non-linear model.	Curcumin	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
33907586-14	2021	In summary, curcumin induced ACC cell apoptosis and inhibited tumour growth by activating the JNK, p38 MAPK and ER stress pathways.	Curcumin	12-20	mitogen-activated protein kinase 8	Homo sapiens	94-97
33684690-0	2021	Curcumin suppresses the malignancy of non-small cell lung cancer by modulating the circ-PRKCA/miR-384/ITGB1 pathway.	Curcumin	0-8	protein kinase C alpha	Homo sapiens	88-93
33684690-0	2021	Curcumin suppresses the malignancy of non-small cell lung cancer by modulating the circ-PRKCA/miR-384/ITGB1 pathway.	Curcumin	0-8	microRNA 384	Homo sapiens	94-101
33684690-6	2021	Curcumin repressed NSCLC growth through regulating circ-PRKCA expression was validated by xenograft assay.	Curcumin	0-8	protein kinase C alpha	Homo sapiens	56-61
33684690-10	2021	After curcumin treatment, the expression tendency of circ-PRKCA, miR-384, and ITGB1 in NSCLC cells was overturned.	Curcumin	6-14	protein kinase C alpha	Homo sapiens	58-63
33684690-10	2021	After curcumin treatment, the expression tendency of circ-PRKCA, miR-384, and ITGB1 in NSCLC cells was overturned.	Curcumin	6-14	microRNA 384	Homo sapiens	65-72
33684690-12	2021	Also, the inhibitory effect of curcumin on xenograft tumor was further enhanced after circ-PRKCA knockdown.	Curcumin	31-39	protein kinase C alpha	Homo sapiens	91-96
33684690-13	2021	Notably, circ-PRKCA regulated ITGB1 expression through sponging miR-384 in curcumin-treated NSCLC cells.	Curcumin	75-83	protein kinase C alpha	Homo sapiens	14-19
33684690-13	2021	Notably, circ-PRKCA regulated ITGB1 expression through sponging miR-384 in curcumin-treated NSCLC cells.	Curcumin	75-83	microRNA 384	Homo sapiens	64-71
33684690-14	2021	CONCLUSIONS: Curcumin inhibited NSCLC growth through downregulating circ-PRKCA, which regulated ITGB1 expression by adsorbing miR-384.	Curcumin	13-21	protein kinase C alpha	Homo sapiens	73-78
33684690-14	2021	CONCLUSIONS: Curcumin inhibited NSCLC growth through downregulating circ-PRKCA, which regulated ITGB1 expression by adsorbing miR-384.	Curcumin	13-21	microRNA 384	Homo sapiens	126-133
33548025-2	2021	The present study investigates the efficacy of curcumin nanoparticles against the cardiotoxic effects of cisplatin by assessment of oxidative stress parameters, Na+,K+-ATPase, acetylcholinesterase (AchE) and tumor necrosis factor-alpha (TNF-alpha) in cardiac tissue in addition to serum lactate dehydrogenase (LDH).	Curcumin	47-55	tumor necrosis factor	Rattus norvegicus	208-235
33548025-2	2021	The present study investigates the efficacy of curcumin nanoparticles against the cardiotoxic effects of cisplatin by assessment of oxidative stress parameters, Na+,K+-ATPase, acetylcholinesterase (AchE) and tumor necrosis factor-alpha (TNF-alpha) in cardiac tissue in addition to serum lactate dehydrogenase (LDH).	Curcumin	47-55	tumor necrosis factor	Rattus norvegicus	237-246
33539684-0	2021	Curcumin suppresses the stemness of non-small cell lung cancer cells via promoting the nuclear-cytoplasm translocation of TAZ.	Curcumin	0-8	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	122-125
33539684-4	2021	In addition, curcumin decreased ALDH activity and the expression of stemness markers (CD133, EpCAM, Oct4).	Curcumin	13-21	epithelial cell adhesion molecule	Homo sapiens	93-98
33539684-9	2021	Mechanistically, it was found that curcumin promoted the nuclear-cytoplasm translocation of TAZ, but not YAP, the critical effectors of Hippo pathway.	Curcumin	35-43	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	92-95
33539684-10	2021	In addition, curcumin destabilzed TAZ protein stability and promoted TAZ protein degradation in lung cancer cells, which is dependent on the proteasome degradation system, not by autophagy lysosome degradation system.	Curcumin	13-21	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	34-37
33539684-10	2021	In addition, curcumin destabilzed TAZ protein stability and promoted TAZ protein degradation in lung cancer cells, which is dependent on the proteasome degradation system, not by autophagy lysosome degradation system.	Curcumin	13-21	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	69-72
33539684-11	2021	Overexpression of TAZ rescued the inhibition of curcumin on the stemness of lung cancer cells.	Curcumin	48-56	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	18-21
33539684-12	2021	Thus, our results suggest that curcumin can attenuate the stemness of lung cancer cells through promoting TAZ protein degradation and thus activating Hippo pathway.	Curcumin	31-39	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	106-109
32292087-12	2021	Decoration of curcumin-loaded liposomes with affibody ZHER2:342 may improve curcumin apoptotic function independently of HER2 expression level.	Curcumin	14-22	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-59
32292087-12	2021	Decoration of curcumin-loaded liposomes with affibody ZHER2:342 may improve curcumin apoptotic function independently of HER2 expression level.	Curcumin	76-84	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-59
33713277-9	2021	In addition, we also found that curcumin inhibited the extracellular matrix (ECM)-receptor interaction pathway via the downregulation of the following genes: GP1BB, COL9A3, COMP, AGRN, ITGB4, LAMA5, COL2A1, ITGB6, ITGA1, and TNC.	Curcumin	32-40	laminin subunit alpha 5	Homo sapiens	192-197
33713277-9	2021	In addition, we also found that curcumin inhibited the extracellular matrix (ECM)-receptor interaction pathway via the downregulation of the following genes: GP1BB, COL9A3, COMP, AGRN, ITGB4, LAMA5, COL2A1, ITGB6, ITGA1, and TNC.	Curcumin	32-40	collagen type II alpha 1 chain	Homo sapiens	199-205
33211286-2	2021	The neuroprotective actions of curcumin (CURC) via modulation of oxidative stress and the PARP1-dependent activated TRPM2 cation channel on the ROS generation and cell death in several neurons have been recognized.	Curcumin	31-39	poly(ADP-ribose) polymerase 1	Homo sapiens	90-95
33211286-2	2021	The neuroprotective actions of curcumin (CURC) via modulation of oxidative stress and the PARP1-dependent activated TRPM2 cation channel on the ROS generation and cell death in several neurons have been recognized.	Curcumin	41-45	poly(ADP-ribose) polymerase 1	Homo sapiens	90-95
33907586-9	2021	The role of the CHOP target gene in curcumin-induced ACC cell apoptosis was verified via lentiviral transfection experiments.	Curcumin	36-44	DNA damage inducible transcript 3	Homo sapiens	16-20
33907586-13	2021	Subsequent in vivo and in vitro results demonstrated that the JNK, p38 MAPK and ER stress pathways were activated in curcumin-treated ACC cells, and that C/EBP homologous protein induction was responsible for curcumin-induced apoptosis of ACC cells.	Curcumin	117-125	mitogen-activated protein kinase 8	Homo sapiens	62-65
34051214-6	2021	Promoter and qRT-PCR assays indicated that curcumin upregulated Hspa1a levels via transcriptional activation.	Curcumin	43-51	heat shock protein family A (Hsp70) member 1A	Homo sapiens	64-70
34047412-8	2021	Curcumin significantly downregulated Rac1 and Fn14 gene expression and significantly decreased p53, NF-kappaB p65, INF-gamma, and PUMA levels in the cardiac tissue.	Curcumin	0-8	TNF receptor superfamily member 12A	Rattus norvegicus	46-50
34047412-8	2021	Curcumin significantly downregulated Rac1 and Fn14 gene expression and significantly decreased p53, NF-kappaB p65, INF-gamma, and PUMA levels in the cardiac tissue.	Curcumin	0-8	synaptotagmin 1	Rattus norvegicus	110-113
34047412-8	2021	Curcumin significantly downregulated Rac1 and Fn14 gene expression and significantly decreased p53, NF-kappaB p65, INF-gamma, and PUMA levels in the cardiac tissue.	Curcumin	0-8	Bcl-2 binding component 3	Rattus norvegicus	130-134
34051214-7	2021	Pharmacological inhibition of MEK, a mechanistic target of rapamycin, p38 mitogen-activated protein kinase, and phosphatidyl 3-inositol kinase suppressed curcumin-mediated HSP70 expression, whereas HSF1 phosphorylation was sensitive only to MEK inhibition.	Curcumin	154-162	mitogen-activated protein kinase kinase 7	Homo sapiens	30-33
34051214-7	2021	Pharmacological inhibition of MEK, a mechanistic target of rapamycin, p38 mitogen-activated protein kinase, and phosphatidyl 3-inositol kinase suppressed curcumin-mediated HSP70 expression, whereas HSF1 phosphorylation was sensitive only to MEK inhibition.	Curcumin	154-162	mechanistic target of rapamycin kinase	Homo sapiens	37-68
34051214-7	2021	Pharmacological inhibition of MEK, a mechanistic target of rapamycin, p38 mitogen-activated protein kinase, and phosphatidyl 3-inositol kinase suppressed curcumin-mediated HSP70 expression, whereas HSF1 phosphorylation was sensitive only to MEK inhibition.	Curcumin	154-162	mitogen-activated protein kinase 14	Homo sapiens	70-106
34051214-7	2021	Pharmacological inhibition of MEK, a mechanistic target of rapamycin, p38 mitogen-activated protein kinase, and phosphatidyl 3-inositol kinase suppressed curcumin-mediated HSP70 expression, whereas HSF1 phosphorylation was sensitive only to MEK inhibition.	Curcumin	154-162	mitogen-activated protein kinase kinase 7	Homo sapiens	241-244
34041781-0	2021	Examination of the effect of curcumin in experimental liver damage created by diethylnitrosamine in swiss albino mice to superoxide dismutase and catalase activities and glutathione, malondialdehyde, advanced oxidation protein products levels.	Curcumin	29-37	catalase	Mus musculus	146-154
33980059-0	2021	Curcumin Can Activate the Nrf2/HO-1 Signaling Pathway and Scavenge Free Radicals in Spinal Cord Injury Treatment.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30
34041781-12	2021	The significant CAT activities were found in both the curcumin protective group and the curcumin treatment group AOPP values decreased in curcumin protective group MDA levels decreased significantly in the curcumin protective group This article is protected by copyright.	Curcumin	54-62	catalase	Mus musculus	16-19
34041781-12	2021	The significant CAT activities were found in both the curcumin protective group and the curcumin treatment group AOPP values decreased in curcumin protective group MDA levels decreased significantly in the curcumin protective group This article is protected by copyright.	Curcumin	88-96	catalase	Mus musculus	16-19
34041781-12	2021	The significant CAT activities were found in both the curcumin protective group and the curcumin treatment group AOPP values decreased in curcumin protective group MDA levels decreased significantly in the curcumin protective group This article is protected by copyright.	Curcumin	88-96	catalase	Mus musculus	16-19
34041781-12	2021	The significant CAT activities were found in both the curcumin protective group and the curcumin treatment group AOPP values decreased in curcumin protective group MDA levels decreased significantly in the curcumin protective group This article is protected by copyright.	Curcumin	88-96	catalase	Mus musculus	16-19
33977872-8	2021	FT-IR and 1H NMR spectra elucidated the removal of curcumin from ethanol-water solutions and its simultaneous encapsulation in beta-CD hydrophobic cavities (released) of fabricated EMs.	Curcumin	51-59	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	127-134
34029211-0	2021	Curcumin inhibits the proliferation and migration of vascular smooth muscle cells by targeting the chemerin / CMKLR1 / LCN2 axis.	Curcumin	0-8	retinoic acid receptor responder (tazarotene induced) 2	Mus musculus	99-107
34054246-6	2022	Epigallocatechin, Catechins, and Curcumin also exhibited high binding affinity (Docking score -7.3, -7.1 and -7.1 kcal/mol) with the Mpro.	Curcumin	33-41	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	133-137
33997938-0	2022	Curcumin Inhibits Viability of Clear Cell Renal Cell Carcinoma by Down-Regulating ADAMTS18 Gene Methylation though NF-kappa B and AKT Signaling Pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	115-125
33997938-0	2022	Curcumin Inhibits Viability of Clear Cell Renal Cell Carcinoma by Down-Regulating ADAMTS18 Gene Methylation though NF-kappa B and AKT Signaling Pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	130-133
33997938-6	2022	Up-regulation of ADAMTS18 gene expression with down-regulation of ADAMTS18 gene methylation was reflected after curcumin treatment, accompanied by down-regulation of nuclear factor kappa B (NF-kappa kB) related protein (p65 and pp65), AKT related protein (AKT and pAKT), and NF-kappa B/AKT common related protein MMP-2.	Curcumin	112-120	AKT serine/threonine kinase 1	Homo sapiens	235-238
33997938-6	2022	Up-regulation of ADAMTS18 gene expression with down-regulation of ADAMTS18 gene methylation was reflected after curcumin treatment, accompanied by down-regulation of nuclear factor kappa B (NF-kappa kB) related protein (p65 and pp65), AKT related protein (AKT and pAKT), and NF-kappa B/AKT common related protein MMP-2.	Curcumin	112-120	nuclear factor kappa B subunit 1	Homo sapiens	275-285
33997938-6	2022	Up-regulation of ADAMTS18 gene expression with down-regulation of ADAMTS18 gene methylation was reflected after curcumin treatment, accompanied by down-regulation of nuclear factor kappa B (NF-kappa kB) related protein (p65 and pp65), AKT related protein (AKT and pAKT), and NF-kappa B/AKT common related protein MMP-2.	Curcumin	112-120	AKT serine/threonine kinase 1	Homo sapiens	256-259
33997938-9	2022	CONCLUSIONS: Curcumin could inhibit the viability of ccRCC by down-regulating ADAMTS18 gene methylation though NF-kappa B and AKT signaling pathway.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	111-121
33997938-9	2022	CONCLUSIONS: Curcumin could inhibit the viability of ccRCC by down-regulating ADAMTS18 gene methylation though NF-kappa B and AKT signaling pathway.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	126-129
34030097-2	2021	Inspired by this, poly (diallyldimethylammonium chloride)-capped curcumin nanoparticles (PDDA@CUR NPs) with high loading capacity were synthesized as signal labels and further applied to dual-model colorimetric and fluorescence ELISA for the detection of C-reactive protein (CRP).	Curcumin	65-73	C-reactive protein	Homo sapiens	255-273
34030097-2	2021	Inspired by this, poly (diallyldimethylammonium chloride)-capped curcumin nanoparticles (PDDA@CUR NPs) with high loading capacity were synthesized as signal labels and further applied to dual-model colorimetric and fluorescence ELISA for the detection of C-reactive protein (CRP).	Curcumin	65-73	C-reactive protein	Homo sapiens	275-278
33857585-0	2021	Anti-Proliferative and Apoptotic Effect of Gemini Curcumin in p53-Wild Type and p53-Mutant Colorectal Cancer Cell Lines.	Curcumin	50-58	tumor protein p53	Homo sapiens	62-65
33857585-0	2021	Anti-Proliferative and Apoptotic Effect of Gemini Curcumin in p53-Wild Type and p53-Mutant Colorectal Cancer Cell Lines.	Curcumin	50-58	tumor protein p53	Homo sapiens	80-83
33980059-6	2021	In this review, we analyze the role of curcumin in activating Nrf2/HO-1 and scavenging free radicals to repair SCI.	Curcumin	39-47	NFE2 like bZIP transcription factor 2	Homo sapiens	62-66
33945061-0	2021	Correction to: Curcumin suppressed proliferation and migration of human retinoblastoma cells through modulating NF-kappaB pathway.	Curcumin	15-23	nuclear factor kappa B subunit 1	Homo sapiens	112-121
33982329-0	2021	A curcumin analogue GL63 inhibits the malignant behaviors of hepatocellular carcinoma by inactivating the JAK2/STAT3 signaling pathway via the circZNF83/miR-324-5p/CDK16 axis.	Curcumin	2-10	signal transducer and activator of transcription 3	Mus musculus	111-116
33982329-0	2021	A curcumin analogue GL63 inhibits the malignant behaviors of hepatocellular carcinoma by inactivating the JAK2/STAT3 signaling pathway via the circZNF83/miR-324-5p/CDK16 axis.	Curcumin	2-10	cyclin-dependent kinase 16	Mus musculus	164-169
33524822-4	2021	The interactions of vitro human serum albumin (HSA) with free curcumin and/or curcumin-Fe3O4/rGO complex have been studied.	Curcumin	62-70	albumin	Homo sapiens	32-45
33524822-4	2021	The interactions of vitro human serum albumin (HSA) with free curcumin and/or curcumin-Fe3O4/rGO complex have been studied.	Curcumin	78-86	albumin	Homo sapiens	32-45
33673739-9	2021	Systemically, curcumin enhanced insulin sensitivity, reduced cortisol levels, and reversed metabolic abnormalities.	Curcumin	14-22	insulin	Homo sapiens	32-39
33544450-3	2021	The aim of this study is to evaluate and compare the hepatoprotective effects of curcumin and nanocurcumin against liver damage caused by sub-acute exposure with PQ via modulation of oxidative stress and genes expression of nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.	Curcumin	81-89	NFE2 like bZIP transcription factor 2	Rattus norvegicus	224-267
33377585-0	2021	Curcumin ameliorates IL-1beta-induced apoptosis by activating autophagy and inhibiting the NF-kappaB signaling pathway in rat primary articular chondrocytes.	Curcumin	0-8	interleukin 1 alpha	Rattus norvegicus	21-29
33377585-4	2021	The aim of present study was to investigate the chondroprotective mechanisms of curcumin on IL-1beta-induced chondrocyte apoptosis in vitro.	Curcumin	80-88	interleukin 1 alpha	Rattus norvegicus	92-100
33377585-6	2021	Curcumin pretreatment reduced IL-1beta-induced articular chondrocyte apoptosis.	Curcumin	0-8	interleukin 1 alpha	Rattus norvegicus	30-38
33377585-7	2021	Additionally, treatment with curcumin increased autophagy in articular chondrocytes, and protected against IL-1beta-induced apoptosis.	Curcumin	29-37	interleukin 1 alpha	Rattus norvegicus	107-115
33377585-8	2021	The curcumin-mediated protection against IL-1beta induced apoptosis was abolished when cells were treated with the autophagy inhibitor 3-MA or transfected with Beclin-1 small interfering RNA.	Curcumin	4-12	interleukin 1 alpha	Rattus norvegicus	41-49
33377585-9	2021	Furthermore, IL-1beta stimulation significantly increased the phosphorylation levels of NF-kappaB p65 and GSK-3beta, and decreased the phosphorylation levels of beta-catenin in articular chondrocytes, and these alterations to the phosphorylation levels were partly reversed by treatment with curcumin.	Curcumin	292-300	interleukin 1 alpha	Rattus norvegicus	13-21
33377585-10	2021	Dual luciferase and electrophoretic mobility shift assays demonstrated that IL-1beta increased NF-kappaB p65 promoter activity in chondrocytes, and this was also reversed by curcumin.	Curcumin	174-182	interleukin 1 alpha	Rattus norvegicus	76-84
33377585-12	2021	Molecular docking and dynamic simulation studies results showed that curcumin could bound to RelA (p65) protein.	Curcumin	69-77	synaptotagmin 1	Rattus norvegicus	93-103
33377585-13	2021	These results indicate that curcumin may suppress IL-1beta-induced chondrocyte apoptosis through activating autophagy and restraining NF-kappaB signaling pathway.	Curcumin	28-36	interleukin 1 alpha	Rattus norvegicus	50-58
33544450-9	2021	Our findings showed that nanocurcumin had better hepatoprotective effect than curcumin in liver damage after PQ exposure most likely through modulation of oxidative stress and genes expression of Nrf2 pathway.	Curcumin	29-37	NFE2 like bZIP transcription factor 2	Rattus norvegicus	196-200
33544450-3	2021	The aim of this study is to evaluate and compare the hepatoprotective effects of curcumin and nanocurcumin against liver damage caused by sub-acute exposure with PQ via modulation of oxidative stress and genes expression of nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.	Curcumin	81-89	NFE2 like bZIP transcription factor 2	Rattus norvegicus	269-273
33760185-8	2021	The results indicated that curcumin reversed the elevations in the pro-inflammatory cytokines IL-1beta and TNF-alpha by inhibiting the NF-kappaB pathway in rats with diarrhea and constipation.	Curcumin	27-35	interleukin 1 alpha	Rattus norvegicus	94-102
33760185-10	2021	Curcumin significantly reversed the increased MLC phosphorylation in the jejunum of the rats with diarrhea, significantly enhanced the reductions in inflammatory mediators, including TNF-alpha and IL-1beta, of rats with constipation and significantly ameliorated the related hyper-motility and hypo-motility in rats with both diarrhea and constipation.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	183-192
33760185-8	2021	The results indicated that curcumin reversed the elevations in the pro-inflammatory cytokines IL-1beta and TNF-alpha by inhibiting the NF-kappaB pathway in rats with diarrhea and constipation.	Curcumin	27-35	tumor necrosis factor	Rattus norvegicus	107-116
33760185-10	2021	Curcumin significantly reversed the increased MLC phosphorylation in the jejunum of the rats with diarrhea, significantly enhanced the reductions in inflammatory mediators, including TNF-alpha and IL-1beta, of rats with constipation and significantly ameliorated the related hyper-motility and hypo-motility in rats with both diarrhea and constipation.	Curcumin	0-8	interleukin 1 alpha	Rattus norvegicus	197-205
33914984-6	2021	RESULTS: Most studies have shown the curative effects of curcumin on clinical and inflammatory parameters of RA and reported different mechanisms; inhibition of mitogen-activated protein kinase family (MAPK), extracellular signal-regulated protein kinase (ERK1/2), activator protein-1 (AP-1), and nuclear factor kappa B (NF-kB) are the main mechanisms associated with the anti-inflammatory function of curcumin in RA.	Curcumin	57-65	mitogen-activated protein kinase 3	Homo sapiens	202-206
33914984-6	2021	RESULTS: Most studies have shown the curative effects of curcumin on clinical and inflammatory parameters of RA and reported different mechanisms; inhibition of mitogen-activated protein kinase family (MAPK), extracellular signal-regulated protein kinase (ERK1/2), activator protein-1 (AP-1), and nuclear factor kappa B (NF-kB) are the main mechanisms associated with the anti-inflammatory function of curcumin in RA.	Curcumin	57-65	mitogen-activated protein kinase 3	Homo sapiens	256-262
33914984-6	2021	RESULTS: Most studies have shown the curative effects of curcumin on clinical and inflammatory parameters of RA and reported different mechanisms; inhibition of mitogen-activated protein kinase family (MAPK), extracellular signal-regulated protein kinase (ERK1/2), activator protein-1 (AP-1), and nuclear factor kappa B (NF-kB) are the main mechanisms associated with the anti-inflammatory function of curcumin in RA.	Curcumin	57-65	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	265-284
33914984-6	2021	RESULTS: Most studies have shown the curative effects of curcumin on clinical and inflammatory parameters of RA and reported different mechanisms; inhibition of mitogen-activated protein kinase family (MAPK), extracellular signal-regulated protein kinase (ERK1/2), activator protein-1 (AP-1), and nuclear factor kappa B (NF-kB) are the main mechanisms associated with the anti-inflammatory function of curcumin in RA.	Curcumin	57-65	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	286-290
33946029-7	2021	RESULTS: Eight weeks of curcumin supplementation and endurance training, whether done separately or simultaneously, significantly reduced fasting blood glucose, glycosylated hemoglobin and serum insulin levels (P < 0.05).	Curcumin	24-32	insulin	Homo sapiens	195-202
33826295-3	2021	Curcumin and homotaurine represent two different types of Abeta aggregation inhibitors.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	58-63
33922657-7	2021	In conclusion, our data indicate that curcumin, which has RAD52 inhibitor activity, is a promising candidate for sensitizing BRCA2-deficient cells to DNA damage-based cancer therapies.	Curcumin	38-46	RAD52 homolog, DNA repair protein	Homo sapiens	58-63
33826295-7	2021	Both curcumin and homotaurine were found to significantly reduce the number of small, nanoscopic Abeta aggregates and the corresponding beta- and cross-beta-sheet signals.	Curcumin	5-13	amyloid beta precursor protein	Homo sapiens	97-102
33894206-6	2021	The anti-cancer effects of curcumin are principally attributed to the regulation of several cellular signaling pathways, including MAPK/PI3K/Akt, Wnt/beta-catenin, JAK/STAT, and NF-kB signaling pathways.	Curcumin	27-35	AKT serine/threonine kinase 1	Homo sapiens	141-144
33887887-2	2021	Curcumin has many pharmacological effects, such as anti-inflammatory, anti-oxidation, antimicrobial, anti-cancer, and improving insulin resistance.	Curcumin	0-8	insulin	Homo sapiens	128-135
33879218-4	2021	Curcumin affects the CFTR protein function primarily as a corrector and potentiator and secondary as an anti-inflammatory and antimicrobial agent.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	21-25
33872054-9	2021	Curcumin is a promising adjuvant of anti-VEGF treatment, improves functional outcomes, and prolongs duration.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	41-45
33875681-1	2021	Curcumin, a phytochemical extracted from Curcuma longa rhizomes, is known to be protective in neurons via activation of Nrf2, a master regulator of endogenous defense against oxidative stress in cells.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	120-124
33875681-2	2021	However, the exact mechanism by which curcumin activates Nrf2 remains controversial.	Curcumin	38-46	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
33875681-0	2021	Curcumin activates Nrf2 through PKCdelta-mediated p62 phosphorylation at Ser351.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
33875681-3	2021	Here, we observed that curcumin induced the expression of genes downstream of Nrf2 such as HO-1, NQO1, and GST-mu1 in neuronal cells, and increased the level of Nrf2 protein.	Curcumin	23-31	NFE2 like bZIP transcription factor 2	Homo sapiens	78-82
33875681-3	2021	Here, we observed that curcumin induced the expression of genes downstream of Nrf2 such as HO-1, NQO1, and GST-mu1 in neuronal cells, and increased the level of Nrf2 protein.	Curcumin	23-31	NAD(P)H quinone dehydrogenase 1	Homo sapiens	97-101
33875681-3	2021	Here, we observed that curcumin induced the expression of genes downstream of Nrf2 such as HO-1, NQO1, and GST-mu1 in neuronal cells, and increased the level of Nrf2 protein.	Curcumin	23-31	NFE2 like bZIP transcription factor 2	Homo sapiens	161-165
33875681-5	2021	Additionally, curcumin-induced Nrf2 activation was abrogated in p62 knockout (-/-) MEFs, indicating that p62 phosphorylation at S351 played a crucial role in curcumin-induced Nrf2 activation.	Curcumin	14-22	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
33875681-5	2021	Additionally, curcumin-induced Nrf2 activation was abrogated in p62 knockout (-/-) MEFs, indicating that p62 phosphorylation at S351 played a crucial role in curcumin-induced Nrf2 activation.	Curcumin	14-22	NFE2 like bZIP transcription factor 2	Homo sapiens	175-179
33875681-5	2021	Additionally, curcumin-induced Nrf2 activation was abrogated in p62 knockout (-/-) MEFs, indicating that p62 phosphorylation at S351 played a crucial role in curcumin-induced Nrf2 activation.	Curcumin	158-166	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
33875681-5	2021	Additionally, curcumin-induced Nrf2 activation was abrogated in p62 knockout (-/-) MEFs, indicating that p62 phosphorylation at S351 played a crucial role in curcumin-induced Nrf2 activation.	Curcumin	158-166	NFE2 like bZIP transcription factor 2	Homo sapiens	175-179
33875681-8	2021	Together, these results suggest that PKCdelta is mainly involved in curcumin-induced p62 phosphorylation and Nrf2 activation.	Curcumin	68-76	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
33875681-9	2021	Accordingly, we demonstrate for the first time that curcumin activates Nrf2 through PKCdelta-mediated p62 phosphorylation at S351.	Curcumin	52-60	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
33864298-3	2021	Previously, our work demonstrated that a diet-derived compound curcumin (diferuloylmethane), represents its antioxidative and antifibrotic application in TGF-beta1-mediated BLM-induced alveolar basal epithelial cells.	Curcumin	63-71	transforming growth factor beta 1	Homo sapiens	154-163
33864298-3	2021	Previously, our work demonstrated that a diet-derived compound curcumin (diferuloylmethane), represents its antioxidative and antifibrotic application in TGF-beta1-mediated BLM-induced alveolar basal epithelial cells.	Curcumin	73-90	transforming growth factor beta 1	Homo sapiens	154-163
33864298-7	2021	The current study discusses two separate proteomics experiments using BLM and TGF-beta1-treated cells with the proteomics approach, various unique target proteins were identified, and proteomic analysis revealed that curcumin reversed the expressions of unique proteins like DNA topoisomerase 2-alpha (TOP2A), kinesin-like protein (KIF11), centromere protein F (CENPF), and so on BLM or TGF-beta1 injury.	Curcumin	217-225	transforming growth factor beta 1	Homo sapiens	78-87
33864298-7	2021	The current study discusses two separate proteomics experiments using BLM and TGF-beta1-treated cells with the proteomics approach, various unique target proteins were identified, and proteomic analysis revealed that curcumin reversed the expressions of unique proteins like DNA topoisomerase 2-alpha (TOP2A), kinesin-like protein (KIF11), centromere protein F (CENPF), and so on BLM or TGF-beta1 injury.	Curcumin	217-225	centromere protein F	Homo sapiens	340-360
33864298-5	2021	To elucidate the underlying mechanism, a quantitative proteomics approach and bioinformatics analysis were employed to identify the protein targets of curcumin in BLM or TGF-beta1-treated cells.	Curcumin	151-159	transforming growth factor beta 1	Homo sapiens	170-179
33864298-7	2021	The current study discusses two separate proteomics experiments using BLM and TGF-beta1-treated cells with the proteomics approach, various unique target proteins were identified, and proteomic analysis revealed that curcumin reversed the expressions of unique proteins like DNA topoisomerase 2-alpha (TOP2A), kinesin-like protein (KIF11), centromere protein F (CENPF), and so on BLM or TGF-beta1 injury.	Curcumin	217-225	centromere protein F	Homo sapiens	362-367
33864298-7	2021	The current study discusses two separate proteomics experiments using BLM and TGF-beta1-treated cells with the proteomics approach, various unique target proteins were identified, and proteomic analysis revealed that curcumin reversed the expressions of unique proteins like DNA topoisomerase 2-alpha (TOP2A), kinesin-like protein (KIF11), centromere protein F (CENPF), and so on BLM or TGF-beta1 injury.	Curcumin	217-225	transforming growth factor beta 1	Homo sapiens	387-396
33866462-0	2021	Interferon Gamma-Mediated Oxidative Stress Induces Apoptosis, Neuroinflammation, Zinc Ion Influx, and TRPM2 Channel Activation in Neuronal Cell Line: Modulator Role of Curcumin.	Curcumin	168-176	interferon gamma	Homo sapiens	0-16
33864298-8	2021	For the first time, the current study reveals that curcumin restores TGF-beta1 induced peroxisomes like PEX-13, PEX-14, PEX-19, and ACOX1.	Curcumin	51-59	transforming growth factor beta 1	Homo sapiens	69-78
33864298-8	2021	For the first time, the current study reveals that curcumin restores TGF-beta1 induced peroxisomes like PEX-13, PEX-14, PEX-19, and ACOX1.	Curcumin	51-59	peroxisomal biogenesis factor 13	Homo sapiens	104-110
33864298-8	2021	For the first time, the current study reveals that curcumin restores TGF-beta1 induced peroxisomes like PEX-13, PEX-14, PEX-19, and ACOX1.	Curcumin	51-59	peroxisomal biogenesis factor 14	Homo sapiens	112-118
33864298-8	2021	For the first time, the current study reveals that curcumin restores TGF-beta1 induced peroxisomes like PEX-13, PEX-14, PEX-19, and ACOX1.	Curcumin	51-59	peroxisomal biogenesis factor 19	Homo sapiens	120-126
33861386-14	2022	In pSS group, but not in controls, median IL-6 levels in supernatant were less in curcumin-treated as compared to PHA-alone subset [5.5 (0.7-1.3) vs 18.3 (12-32) ng/ml; p = 0.04].	Curcumin	82-90	interleukin 6	Homo sapiens	42-46
33923773-6	2021	The results showed that both GPL and SPC exerted excellent synergistic effect with CUR in inhibiting the lipopolysaccharide (LPS)-induced secretion of nitric oxide (NO), reactive oxygen species (ROS), and pro-inflammatory genes (tumor necrosis factor (TNF)-alpha, interleukin 1beta (IL-beta), and interleukin 6 (IL-6)) in RAW264.7 cells.	Curcumin	83-86	sparse coat	Mus musculus	37-40
33861386-15	2022	mRNA expression levels of IL-6 and IL-1beta were lower in curcumin-treated samples as compared to PHA alone, both amongst pSS and control groups (p = 0.0009 and p = 0.04, respectively).	Curcumin	58-66	interleukin 6	Homo sapiens	26-30
33861386-17	2022	In conclusion, curcumin reduced secretion of IL-6 levels by salivary gland tissue of patients with pSS.	Curcumin	15-23	interleukin 6	Homo sapiens	45-49
33861386-18	2022	Curcumin also suppressed PHA-induced mRNA expression levels of IL-6 and IL-1beta in MSG tissue of patients with pSS and controls.	Curcumin	0-8	interleukin 6	Homo sapiens	63-67
33647403-2	2021	In this study, transferrin (Tf) bioconjugated solid lipid nanoparticles (SLNs) were developed and loaded with curcumin (CRC) for active targeting of prostate cancer cells.	Curcumin	110-118	transferrin	Homo sapiens	15-26
33898809-0	2021	Exploring the molecular structure, vibrational spectroscopic, quantum chemical calculation and molecular docking studies of curcumin: A potential PI3K/AKT uptake inhibitor.	Curcumin	124-132	AKT serine/threonine kinase 1	Homo sapiens	151-154
33937075-0	2021	The Diarylheptanoid Curcumin Induces MYC Inhibition and Cross-Links This Oncoprotein to the Coactivator TRRAP.	Curcumin	20-28	transformation/transcription domain associated protein	Homo sapiens	104-109
33937075-7	2021	Furthermore, in curcumin-treated cells, the endogenous 60-kDa MYC protein is covalently and specifically cross-linked to one of its transcriptional interaction partners, namely the 434-kDa transformation/transcription domain associated protein (TRRAP).	Curcumin	16-24	transformation/transcription domain associated protein	Homo sapiens	189-243
33937075-7	2021	Furthermore, in curcumin-treated cells, the endogenous 60-kDa MYC protein is covalently and specifically cross-linked to one of its transcriptional interaction partners, namely the 434-kDa transformation/transcription domain associated protein (TRRAP).	Curcumin	16-24	transformation/transcription domain associated protein	Homo sapiens	245-250
33937075-11	2021	Curcumin-mediated covalent binding of MYC to TRRAP reduces the protein amounts of both interaction partners but does not downregulate TP53, so that the growth-arresting effect of wild type TP53 could prevail.	Curcumin	0-8	transformation/transcription domain associated protein	Homo sapiens	45-50
33937075-11	2021	Curcumin-mediated covalent binding of MYC to TRRAP reduces the protein amounts of both interaction partners but does not downregulate TP53, so that the growth-arresting effect of wild type TP53 could prevail.	Curcumin	0-8	tumor protein p53	Homo sapiens	189-193
33727082-0	2021	Transferrin-functionalized lipid nanoparticles for curcumin brain delivery.	Curcumin	51-59	transferrin	Homo sapiens	0-11
33354908-8	2021	Compared with UUO rats, renal fibrosis was attenuated and NLRP3 inflammasome activation was inhibited in curcumin-treated rats.	Curcumin	105-113	NLR family, pyrin domain containing 3	Rattus norvegicus	58-63
33825246-6	2021	Most of the evidence is in-vivo and in-vitro studies that demonstrate that curcumin possesses regulatory properties on FFAs levels through its effects on FAS and beta-oxidation activity as well as desaturation system, which could improve insulin resistance, obesity, and other FFAs-related disorders.	Curcumin	75-83	insulin	Homo sapiens	238-245
33918207-7	2021	Numerous in vitro and in vivo studies show that curcumin may interact with many cellular targets (NF-kappaB, JAKs/STATs, MAPKs, TNF-gamma, IL-6, PPARgamma, and TRPV1) and effectively reduce the progression of IBD with promising results.	Curcumin	48-56	nuclear factor kappa B subunit 1	Homo sapiens	98-107
33918207-7	2021	Numerous in vitro and in vivo studies show that curcumin may interact with many cellular targets (NF-kappaB, JAKs/STATs, MAPKs, TNF-gamma, IL-6, PPARgamma, and TRPV1) and effectively reduce the progression of IBD with promising results.	Curcumin	48-56	interleukin 6	Homo sapiens	139-143
33918207-7	2021	Numerous in vitro and in vivo studies show that curcumin may interact with many cellular targets (NF-kappaB, JAKs/STATs, MAPKs, TNF-gamma, IL-6, PPARgamma, and TRPV1) and effectively reduce the progression of IBD with promising results.	Curcumin	48-56	peroxisome proliferator activated receptor gamma	Homo sapiens	145-154
33354908-10	2021	Additionally, curcumin inhibited the PI3K/AKT/mTOR pathway.	Curcumin	14-22	AKT serine/threonine kinase 1	Rattus norvegicus	42-45
33354908-11	2021	These results indicate that curcumin is a promising treatment agent for RIF, and its antifibrotic effects may be mediated by the inhibition of NLRP3 inflammasome activity through the regulation of autophagy and protection of mitochondrial function in UUO rats.	Curcumin	28-36	NLR family, pyrin domain containing 3	Rattus norvegicus	143-148
33373686-11	2021	Curcumin antagonised the NECTIN-4-induced angiogenesis through inhibition of PI3K-AKT mediated eNOS pathway and Veliparib synergized the effect of Curcumin.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	82-85
33373686-11	2021	Curcumin antagonised the NECTIN-4-induced angiogenesis through inhibition of PI3K-AKT mediated eNOS pathway and Veliparib synergized the effect of Curcumin.	Curcumin	0-8	nitric oxide synthase 3	Homo sapiens	95-99
33655321-0	2021	Curcumin protects BEAS-2B cells from PM2.5-induced oxidative stress and inflammation by activating NRF2/antioxidant response element pathways.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	99-103
33548579-9	2021	Molecular analysis revealed that curcumin exerted protective effects via suppressing neuroinflammation induced by microglial activation, regulating the triggering receptor expressed on myeloid cells 2 (TREM2)/toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-kappaB) pathway, alleviating apoptosis, and reducing nod-like receptor protein 3 (NLRP3)-dependent pyroptosis.	Curcumin	33-41	toll-like receptor 4	Rattus norvegicus	209-229
33548579-9	2021	Molecular analysis revealed that curcumin exerted protective effects via suppressing neuroinflammation induced by microglial activation, regulating the triggering receptor expressed on myeloid cells 2 (TREM2)/toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-kappaB) pathway, alleviating apoptosis, and reducing nod-like receptor protein 3 (NLRP3)-dependent pyroptosis.	Curcumin	33-41	toll-like receptor 4	Rattus norvegicus	231-235
33548579-9	2021	Molecular analysis revealed that curcumin exerted protective effects via suppressing neuroinflammation induced by microglial activation, regulating the triggering receptor expressed on myeloid cells 2 (TREM2)/toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-kappaB) pathway, alleviating apoptosis, and reducing nod-like receptor protein 3 (NLRP3)-dependent pyroptosis.	Curcumin	33-41	NLR family, pyrin domain containing 3	Rattus norvegicus	316-343
33548579-9	2021	Molecular analysis revealed that curcumin exerted protective effects via suppressing neuroinflammation induced by microglial activation, regulating the triggering receptor expressed on myeloid cells 2 (TREM2)/toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-kappaB) pathway, alleviating apoptosis, and reducing nod-like receptor protein 3 (NLRP3)-dependent pyroptosis.	Curcumin	33-41	NLR family, pyrin domain containing 3	Rattus norvegicus	345-350
33655321-6	2021	Moreover, curcumin reduced the PM2.5-induced expression and production of inflammatory factors, and induced the expression of the anti-inflammatory factors, interleukin (IL)-5 and IL-13.	Curcumin	10-18	interleukin 13	Homo sapiens	180-185
33655321-7	2021	Taken together, the present study demonstrates that curcumin protects BEAS-2B cells against PM2.5-induced oxidative damage and inflammation, and prevents cell apoptosis by increasing the activation of NRF2-related pathways.	Curcumin	52-60	NFE2 like bZIP transcription factor 2	Homo sapiens	201-205
33655321-5	2021	Western blot analysis revealed that curcumin increased the expression of nuclear factor erythroid 2-related factor 2 (NRF2) and regulated the transcription of downstream genes, particularly those encoding antioxidant enzymes.	Curcumin	36-44	NFE2 like bZIP transcription factor 2	Homo sapiens	73-116
33655321-5	2021	Western blot analysis revealed that curcumin increased the expression of nuclear factor erythroid 2-related factor 2 (NRF2) and regulated the transcription of downstream genes, particularly those encoding antioxidant enzymes.	Curcumin	36-44	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
33581265-10	2021	Curcumin helps to regulate the balance of antioxidant and reactive oxygen species by targeting various molecules (NF-kappaB, STAT3, MAPK, Mfn2, Nrf2, pro-inflammatory cytokines).	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	114-123
33581265-10	2021	Curcumin helps to regulate the balance of antioxidant and reactive oxygen species by targeting various molecules (NF-kappaB, STAT3, MAPK, Mfn2, Nrf2, pro-inflammatory cytokines).	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	125-130
33581265-10	2021	Curcumin helps to regulate the balance of antioxidant and reactive oxygen species by targeting various molecules (NF-kappaB, STAT3, MAPK, Mfn2, Nrf2, pro-inflammatory cytokines).	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	144-148
33732362-9	2021	In addition, the results demonstrated that curcumin inhibited the TLR4/NF-kappaB signaling pathway and the expression of inflammatory factors, including IL-6, IL-1beta, prostaglandin E2 and cyclooxygenase-2, in mouse xenograft tumors.	Curcumin	43-51	toll-like receptor 4	Mus musculus	66-70
33411217-8	2021	Conversely, various doses of curcumin attenuated DCAA-induced oxidative stress, inflammation response and impaired synaptic plasticity, while elevating cAMP, PKA, p-CREB, BDNF, PSD-95, SYP levels.	Curcumin	29-37	DLG associated protein 2	Rattus norvegicus	177-183
33900118-0	2021	Topical delivery of curcumin-loaded transfersomes gel ameliorated rheumatoid arthritis by inhibiting NF-kappabeta pathway.	Curcumin	20-28	nuclear factor kappa B subunit 1	Homo sapiens	101-113
33649826-0	2021	Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	98-101
33649826-6	2021	Western blotting results indicated that curcumin dose-dependently suppressed the phosphorylation of AKT, PRAS40, 4E-BP1, P70S6K, RAF-1 and p27 in AML cell lines (ML-2 and OCI-AML5).	Curcumin	40-48	AKT serine/threonine kinase 1	Homo sapiens	100-103
33649826-6	2021	Western blotting results indicated that curcumin dose-dependently suppressed the phosphorylation of AKT, PRAS40, 4E-BP1, P70S6K, RAF-1 and p27 in AML cell lines (ML-2 and OCI-AML5).	Curcumin	40-48	AKT1 substrate 1	Homo sapiens	105-111
33649826-6	2021	Western blotting results indicated that curcumin dose-dependently suppressed the phosphorylation of AKT, PRAS40, 4E-BP1, P70S6K, RAF-1 and p27 in AML cell lines (ML-2 and OCI-AML5).	Curcumin	40-48	dynactin subunit 6	Homo sapiens	139-142
33649826-7	2021	It was also demonstrated that curcumin regulated the cell cycle- and apoptosis-related proteins (cyclin D1, p21, Bcl2, cleaved-caspase-3 and cleaved-PARP), leading to cell cycle arrest and apoptosis in both ML-2 and OCI-AML5 cells.	Curcumin	30-38	BCL2 apoptosis regulator	Homo sapiens	113-117
33649826-8	2021	These effects of curcumin were enhanced by the AKT inhibitor afuresertib but were suppressed by the AKT activator SC-79, indicating that curcumin functions via AKT.	Curcumin	17-25	AKT serine/threonine kinase 1	Homo sapiens	47-50
33649826-8	2021	These effects of curcumin were enhanced by the AKT inhibitor afuresertib but were suppressed by the AKT activator SC-79, indicating that curcumin functions via AKT.	Curcumin	17-25	AKT serine/threonine kinase 1	Homo sapiens	100-103
33649826-8	2021	These effects of curcumin were enhanced by the AKT inhibitor afuresertib but were suppressed by the AKT activator SC-79, indicating that curcumin functions via AKT.	Curcumin	17-25	AKT serine/threonine kinase 1	Homo sapiens	100-103
33649826-8	2021	These effects of curcumin were enhanced by the AKT inhibitor afuresertib but were suppressed by the AKT activator SC-79, indicating that curcumin functions via AKT.	Curcumin	137-145	AKT serine/threonine kinase 1	Homo sapiens	100-103
33649826-8	2021	These effects of curcumin were enhanced by the AKT inhibitor afuresertib but were suppressed by the AKT activator SC-79, indicating that curcumin functions via AKT.	Curcumin	137-145	AKT serine/threonine kinase 1	Homo sapiens	100-103
33649826-10	2021	Collectively, the present study demonstrated that curcumin exerted anti-AML roles by inactivating AKT and these findings may aid in the treatment of AML.	Curcumin	50-58	AKT serine/threonine kinase 1	Homo sapiens	98-101
33732362-9	2021	In addition, the results demonstrated that curcumin inhibited the TLR4/NF-kappaB signaling pathway and the expression of inflammatory factors, including IL-6, IL-1beta, prostaglandin E2 and cyclooxygenase-2, in mouse xenograft tumors.	Curcumin	43-51	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-80
33732362-9	2021	In addition, the results demonstrated that curcumin inhibited the TLR4/NF-kappaB signaling pathway and the expression of inflammatory factors, including IL-6, IL-1beta, prostaglandin E2 and cyclooxygenase-2, in mouse xenograft tumors.	Curcumin	43-51	interleukin 6	Mus musculus	153-157
33656766-11	2021	Meanwhile, the protein level of ACSL4 was higher and the levels of SLC7A11 and GPX4 were lower in curcumin group than that in control group.	Curcumin	98-106	acyl-CoA synthetase long chain family member 4	Homo sapiens	32-37
33200488-5	2021	Curcumin intake significantly decreased fasting plasma glucose (p = .02), insulin (p = .01), insulin resistance (p = .02), and significantly increased insulin sensitivity (p = .008) compared with the placebo.	Curcumin	0-8	insulin	Homo sapiens	74-81
33200488-5	2021	Curcumin intake significantly decreased fasting plasma glucose (p = .02), insulin (p = .01), insulin resistance (p = .02), and significantly increased insulin sensitivity (p = .008) compared with the placebo.	Curcumin	0-8	insulin	Homo sapiens	93-100
33200488-5	2021	Curcumin intake significantly decreased fasting plasma glucose (p = .02), insulin (p = .01), insulin resistance (p = .02), and significantly increased insulin sensitivity (p = .008) compared with the placebo.	Curcumin	0-8	insulin	Homo sapiens	93-100
33656766-12	2021	Incubation of ferroptosis inhibitors ferrostatin-1 (Fer-1) or knockdown of iron-responsive element-binding protein 2 (IREB2) notably weakened curcumin-induced anti-tumor effect and ferroptosis in A549 and H1299 cells.	Curcumin	142-150	iron responsive element binding protein 2	Homo sapiens	75-116
33656766-12	2021	Incubation of ferroptosis inhibitors ferrostatin-1 (Fer-1) or knockdown of iron-responsive element-binding protein 2 (IREB2) notably weakened curcumin-induced anti-tumor effect and ferroptosis in A549 and H1299 cells.	Curcumin	142-150	iron responsive element binding protein 2	Homo sapiens	118-123
32694760-8	2021	In CCD-18Co cells and RAW264.7 cells, curcumin dose-dependently activated PPARgamma and CREB, whereas PPARgamma antagonist GW9662 (1 muM) or cAMP response element (CREB) inhibitor KG-501 (10 muM) significantly decreased the boosting effect of curcumin on HGF expression.	Curcumin	38-46	cAMP responsive element binding protein 1	Mus musculus	164-168
33753114-9	2021	After co-culture of Hep3B cells and PBMCs, curcumin had a synergistic effect with anti-PD-1 to slow Hep3B cell proliferation, activate lymphocytes, inhibit immune evasion, and down-regulate TGF-beta1 expression.	Curcumin	43-51	transforming growth factor beta 1	Homo sapiens	190-199
33753114-10	2021	Functionally, curcumin inhibited thrombin to reduce P300-induced histone acetylation in the TGF-beta1 promoter region, and anti-PD-1 suppressed binding of PD-1 and PD-L1 to promote immune activity; the combination of the two showed better in vitro anti-cancer effects.	Curcumin	14-22	coagulation factor II, thrombin	Homo sapiens	33-41
33753114-10	2021	Functionally, curcumin inhibited thrombin to reduce P300-induced histone acetylation in the TGF-beta1 promoter region, and anti-PD-1 suppressed binding of PD-1 and PD-L1 to promote immune activity; the combination of the two showed better in vitro anti-cancer effects.	Curcumin	14-22	transforming growth factor beta 1	Homo sapiens	92-101
33555192-0	2021	alpha-Lactalbumin Self-Assembled Nanoparticles with Various Morphologies, Stiffnesses, and Sizes as Pickering Stabilizers for Oil-in-Water Emulsions and Delivery of Curcumin.	Curcumin	165-173	lactalbumin alpha	Homo sapiens	0-17
33655859-2	2021	OBJECTIVE: In this study, we evaluated the effectiveness of several curcumin analogs on four MM cell lines (SK-MEL-28, MeWo, A-375, and CHL-1), and explored their underlying mechanisms of action.	Curcumin	68-76	cell adhesion molecule L1 like	Homo sapiens	136-141
33688227-0	2021	Effects of Curcumin on High Glucose-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells Through the TLR4-NF-kappaB Signaling Pathway.	Curcumin	11-19	toll-like receptor 4	Rattus norvegicus	127-131
33688227-6	2021	Furthermore, Curcumin was found to inhibit the TLR4-NF-kappaB signaling activation in HG-induced EMT of NRK-52E cells.	Curcumin	13-21	toll-like receptor 4	Rattus norvegicus	47-51
33688227-7	2021	Conclusion: The present study provides evidence suggesting a novel mechanism that Curcumin exerts the anti-fibrosis effects via inhibiting activation of the TLR4-NF-kappaB signal pathway and consequently protecting the HG-induced EMT in renal tubular epithelial cells.	Curcumin	82-90	toll-like receptor 4	Rattus norvegicus	157-161
32694760-8	2021	In CCD-18Co cells and RAW264.7 cells, curcumin dose-dependently activated PPARgamma and CREB, whereas PPARgamma antagonist GW9662 (1 muM) or cAMP response element (CREB) inhibitor KG-501 (10 muM) significantly decreased the boosting effect of curcumin on HGF expression.	Curcumin	38-46	cAMP responsive element binding protein 1	Mus musculus	88-92
32694760-11	2021	Together, curcumin promotes the expression of HGF in colonic fibroblasts and macrophages by activating PPARgamma and CREB via an induction of 15d-PGJ2, and the HGF enters the lungs giving rise to an anti-PF effect.	Curcumin	10-18	cAMP responsive element binding protein 1	Mus musculus	117-121
33907673-0	2021	The positive effect of short-term nano-curcumin therapy on insulin resistance and serum levels of afamin in patients with metabolic syndrome.	Curcumin	39-47	insulin	Homo sapiens	59-66
33907673-4	2021	This study aimed to evaluate the effects of nano-curcumin therapy on insulin resistance and serum level of afamin in patients with MS. Materials and Methods: Thirty MS patients (15 males and 15 females) received 80 mg/daily nano-curcumin for two months.	Curcumin	49-57	insulin	Homo sapiens	69-76
33907673-6	2021	Results: Comparing pre- and post-treatment with nano-curcumin values revealed a significant decrease in fasting plasma glucose (FPG) (p=0.017), insulin, homeostatic model assessment of insulin resistance (HOMA-IR) (p=0.006), and afamin (p=0.047).	Curcumin	53-61	insulin	Homo sapiens	144-151
33907673-6	2021	Results: Comparing pre- and post-treatment with nano-curcumin values revealed a significant decrease in fasting plasma glucose (FPG) (p=0.017), insulin, homeostatic model assessment of insulin resistance (HOMA-IR) (p=0.006), and afamin (p=0.047).	Curcumin	53-61	insulin	Homo sapiens	185-192
33907673-8	2021	Conclusion: Results suggest that taking nano-curcumin for 60 days may have positive effects on afamin, FPG, insulin, and HOMA-IR in patients with MS, but would not significantly affect other metabolic profiles.	Curcumin	45-53	insulin	Homo sapiens	108-115
34014157-12	2021	After curcumin treatment, the changes in CCL2 were positively associated with the changes in IL-6.	Curcumin	6-14	interleukin 6	Homo sapiens	93-97
34014157-15	2021	Nevertheless, curcumin could reverse the HSP65-induced CCL2 upregulation through restraining JAK2/AKT/STAT3 pathway.	Curcumin	14-22	AKT serine/threonine kinase 1	Homo sapiens	98-101
34014157-15	2021	Nevertheless, curcumin could reverse the HSP65-induced CCL2 upregulation through restraining JAK2/AKT/STAT3 pathway.	Curcumin	14-22	signal transducer and activator of transcription 3	Homo sapiens	102-107
34014157-16	2021	The inhibitory effect of curcumin on the JAK2/AKT/STAT3 pathway was even more obvious than that of methotrexate and tofacitinib.	Curcumin	25-33	AKT serine/threonine kinase 1	Homo sapiens	46-49
34014157-16	2021	The inhibitory effect of curcumin on the JAK2/AKT/STAT3 pathway was even more obvious than that of methotrexate and tofacitinib.	Curcumin	25-33	signal transducer and activator of transcription 3	Homo sapiens	50-55
34014157-17	2021	CONCLUSIONS: Curcumin alleviated inflammation in TAK by downregulating CCL2 overexpression in AAFs through inhibiting the JAK2/AKT/STAT3 signalling pathway.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	127-130
34014157-17	2021	CONCLUSIONS: Curcumin alleviated inflammation in TAK by downregulating CCL2 overexpression in AAFs through inhibiting the JAK2/AKT/STAT3 signalling pathway.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	131-136
33541570-2	2021	The inclusion complex formation of curcumin (CUR), as a model anticancer compound, with beta-CD was characterized by fluorescence and Fourier transform infrared (FTIR) spectroscopy.	Curcumin	35-43	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	88-95
33500696-2	2021	Curcumin (Cur), a naturally derived compound, is reported to have broad-spectrum anticancer activity and is considered as an effective nuclear factor-kappaB (NF-kappaB) inhibitor.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	135-156
33500696-2	2021	Curcumin (Cur), a naturally derived compound, is reported to have broad-spectrum anticancer activity and is considered as an effective nuclear factor-kappaB (NF-kappaB) inhibitor.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	158-167
33500696-2	2021	Curcumin (Cur), a naturally derived compound, is reported to have broad-spectrum anticancer activity and is considered as an effective nuclear factor-kappaB (NF-kappaB) inhibitor.	Curcumin	0-3	nuclear factor kappa B subunit 1	Homo sapiens	135-156
33500696-2	2021	Curcumin (Cur), a naturally derived compound, is reported to have broad-spectrum anticancer activity and is considered as an effective nuclear factor-kappaB (NF-kappaB) inhibitor.	Curcumin	0-3	nuclear factor kappa B subunit 1	Homo sapiens	158-167
33495815-3	2021	Our previous studies have reported that curcumin (Cur) and ginkgolide B (GB) inhibited cystogenesis by regulating the Ras/ERK MAPK signaling pathway.	Curcumin	40-48	mitogen-activated protein kinase 1	Mus musculus	122-125
33574907-8	2021	The expression levels of apoptotic factors associated with NF-kappaB activation, including TNF-alpha and caspase-3 were increased in U87 cells by CCM treatment, while p53 expression, a tumor suppressor, was shown to be decreased.	Curcumin	146-149	nuclear factor kappa B subunit 1	Homo sapiens	59-68
33574907-8	2021	The expression levels of apoptotic factors associated with NF-kappaB activation, including TNF-alpha and caspase-3 were increased in U87 cells by CCM treatment, while p53 expression, a tumor suppressor, was shown to be decreased.	Curcumin	146-149	tumor necrosis factor	Homo sapiens	91-100
33574907-8	2021	The expression levels of apoptotic factors associated with NF-kappaB activation, including TNF-alpha and caspase-3 were increased in U87 cells by CCM treatment, while p53 expression, a tumor suppressor, was shown to be decreased.	Curcumin	146-149	caspase 3	Homo sapiens	105-114
33574907-9	2021	Based on the results of the present study, CCM may exert its anti-tumor effects in U87 cells by inhibiting the HSP60/TLR-4/MYD88/NF-kappaB pathway and inducing tumor cell apoptosis.	Curcumin	43-46	nuclear factor kappa B subunit 1	Homo sapiens	129-138
33495815-3	2021	Our previous studies have reported that curcumin (Cur) and ginkgolide B (GB) inhibited cystogenesis by regulating the Ras/ERK MAPK signaling pathway.	Curcumin	40-48	mitogen-activated protein kinase 1	Mus musculus	126-130
33495815-3	2021	Our previous studies have reported that curcumin (Cur) and ginkgolide B (GB) inhibited cystogenesis by regulating the Ras/ERK MAPK signaling pathway.	Curcumin	50-53	mitogen-activated protein kinase 1	Mus musculus	122-125
33495815-3	2021	Our previous studies have reported that curcumin (Cur) and ginkgolide B (GB) inhibited cystogenesis by regulating the Ras/ERK MAPK signaling pathway.	Curcumin	50-53	mitogen-activated protein kinase 1	Mus musculus	126-130
33231085-0	2021	Curcumin combined with low-intensity ultrasound suppresses the growth of glioma cells via inhibition of the AKT pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	108-111
32985484-4	2021	Our results revealed that solid lipid nanoparticle loading with curcumin and dexanabinol increased the mRNA and protein expression levels of the mature neuronal markers neuronal nuclei, mitogen-activated protein 2, and neuron-specific beta-tubulin III, promoted the release of dopamine and norepinephrine, and increased the mRNA expression of CBR1 and the downstream genes Rasgef1c and Egr1, and simultaneously improved rat locomotor function.	Curcumin	64-72	early growth response 1	Rattus norvegicus	386-390
33231085-7	2021	And cell apoptosis was promoted after LIUS-curcumin combination treatment, characterized by the occurrence of more apoptotic cells and a significant increase in Bax level and attenuated Bcl-2 expression.	Curcumin	43-51	BCL2 associated X, apoptosis regulator	Homo sapiens	161-164
33231085-7	2021	And cell apoptosis was promoted after LIUS-curcumin combination treatment, characterized by the occurrence of more apoptotic cells and a significant increase in Bax level and attenuated Bcl-2 expression.	Curcumin	43-51	BCL2 apoptosis regulator	Homo sapiens	186-191
33231085-8	2021	Moreover, the role of LIUS-curcumin combination in downregulation of the AKT pathway was observed.	Curcumin	27-35	AKT serine/threonine kinase 1	Homo sapiens	73-76
33231085-9	2021	The AKT pathway activator SC79 reversed apoptosis and anti-proliferation induced by combined treatment with LIUS and curcumin.	Curcumin	117-125	AKT serine/threonine kinase 1	Homo sapiens	4-7
33231085-10	2021	Our findings show that LIUS in combination with low-dose curcumin synergistically suppresses the growth of glioma cells via inhibition of the AKT pathway.	Curcumin	57-65	AKT serine/threonine kinase 1	Homo sapiens	142-145
33503518-10	2021	All experimental groups presented predominance of mixed-type failure, excepting the methylene blue group at higher concentration activated by red laser, and the curcumin photosensitizer at both concentrations activated by blue LED.	Curcumin	161-169	small integral membrane protein 10 like 2A	Homo sapiens	227-230
33669070-0	2021	P62/SQSTM1/Keap1/NRF2 Axis Reduces Cancer Cells Death-Sensitivity in Response to Zn(II)-Curcumin Complex.	Curcumin	88-96	kelch like ECH associated protein 1	Homo sapiens	11-16
33669070-0	2021	P62/SQSTM1/Keap1/NRF2 Axis Reduces Cancer Cells Death-Sensitivity in Response to Zn(II)-Curcumin Complex.	Curcumin	88-96	NFE2 like bZIP transcription factor 2	Homo sapiens	17-21
33669070-2	2021	Curcumin has been shown to activate NRF2 that has cytotprotective or protumorigenic roles according to tumor stage.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
33551001-11	2021	Furthermore, curcumin promoted AMPK phosphorylation and PGC-1alpha deacetylation.	Curcumin	13-21	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	31-35
33617879-3	2021	Curcumin has been previously identified as an excellent DYRK-2 inhibitor, but curcumin"s fate is tainted by its instability in the cellular environment.	Curcumin	0-8	dual specificity tyrosine phosphorylation regulated kinase 2	Homo sapiens	56-62
34000577-0	2021	Curcumin reverses doxorubicin resistance in colon cancer cells at the metabolic level.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	18-40
33359484-3	2021	Physical encapsulation is advantageous due to requiring no chemical modification of drug molecules, but many drugs, for instance, camptothecin (CPT) and curcumin (CCM), though very hydrophobic, can not be loaded in or form nanoformulations with albumin.	Curcumin	153-161	albumin	Homo sapiens	245-252
33359484-3	2021	Physical encapsulation is advantageous due to requiring no chemical modification of drug molecules, but many drugs, for instance, camptothecin (CPT) and curcumin (CCM), though very hydrophobic, can not be loaded in or form nanoformulations with albumin.	Curcumin	163-166	albumin	Homo sapiens	245-252
33551001-11	2021	Furthermore, curcumin promoted AMPK phosphorylation and PGC-1alpha deacetylation.	Curcumin	13-21	PPARG coactivator 1 alpha	Rattus norvegicus	56-66
33551001-13	2021	Conclusion: The present results suggest that curcumin increases cAMP levels via inhibition of PDE4A phosphorylation, which induces mitochondrial biogenesis through a cAMP/PKA/AMPK signalling pathway.	Curcumin	45-53	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	175-179
33538682-8	2021	Curcumin also increased antioxidant enzyme expression, suppressed lipid peroxidation, and decreased interleukin-6 secretion in PC12 cells subjected to GSD.	Curcumin	0-8	interleukin 6	Rattus norvegicus	100-113
33538682-9	2021	In addition, pretreatment with curcumin down-regulated pro-apoptotic (Bax), and up-regulated antiapoptotic (Bcl2) mediators.	Curcumin	31-39	BCL2, apoptosis regulator	Rattus norvegicus	108-112
33278547-5	2021	RESULTS: Our results showed that the Curcumin binds p53Y220C with Kd = 3.169 +- 0.257 muM and it increases the DNA binding affinity of the mutant by 4-fold with Kd = 851.29 +- 186.27 nM.	Curcumin	37-45	tumor protein p53	Homo sapiens	52-55
33278547-7	2021	By caspase and Annexin V assays, we could demonstrate Curcumin at 3 muM to 8 muM concentration could initiate p53 mediated apoptosis in BxPC-3 cell lines.	Curcumin	54-62	tumor protein p53	Homo sapiens	110-113
33003239-0	2021	Curcumin Promotes Collagen Type I, Keratinocyte Growth Factor-1, and Epidermal Growth Factor Receptor Expressions in the In Vitro Wound Healing Model of Human Gingival Fibroblasts.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	69-101
33360051-6	2021	In several studies on various model organisms it has been shown that the lifespan extension via curcumin treatment was connected with enhanced superoxide dismutase (SOD) activity, and also declined malondialdehyde (MDA) and lipofuscin levels.	Curcumin	96-104	superoxide dismutase 1	Homo sapiens	143-163
33360051-6	2021	In several studies on various model organisms it has been shown that the lifespan extension via curcumin treatment was connected with enhanced superoxide dismutase (SOD) activity, and also declined malondialdehyde (MDA) and lipofuscin levels.	Curcumin	96-104	superoxide dismutase 1	Homo sapiens	165-168
33003239-9	2021	RESULTS:  In unwounded hGFs, curcumin significantly increased KGF-1 and EGFR expressions but not COL1 mRNA expression.	Curcumin	29-37	epidermal growth factor receptor	Homo sapiens	72-76
33003239-10	2021	Interestingly, curcumin significantly upregulated COL1, KGF-1, and EGFR expressions in the in vitro wound healing model.	Curcumin	15-23	epidermal growth factor receptor	Homo sapiens	67-71
33003239-6	2021	PD98059 was used to elucidate whether extracellular signal regulated kinase (ERK) signaling is involved in the curcumin-regulated gene expression in hGFs.	Curcumin	111-119	mitogen-activated protein kinase 1	Homo sapiens	38-75
33003239-11	2021	Furthermore, PD98059 significantly decreased the curcumin-induced COL1 and EGFR expressions, but did not significantly affect KGF-1 upregulation by curcumin.	Curcumin	49-57	epidermal growth factor receptor	Homo sapiens	75-79
33003239-13	2021	CONCLUSION:  Curcumin induced KGF-1 and EGFR expressions in unwounded hGFs.	Curcumin	13-21	epidermal growth factor receptor	Homo sapiens	40-44
33003239-6	2021	PD98059 was used to elucidate whether extracellular signal regulated kinase (ERK) signaling is involved in the curcumin-regulated gene expression in hGFs.	Curcumin	111-119	mitogen-activated protein kinase 1	Homo sapiens	77-80
33376508-9	2021	Curcumin was also revealed to downregulate c-Jun N-terminal kinases (JNK), cytochrome c, caspase-3 and caspase-9 expression upon treatment with 100 and 200 mg/kg curcumin, which may result in inhibition of the mitochondrial apoptotic pathway in renal cells.	Curcumin	0-8	caspase 9	Rattus norvegicus	103-112
33003239-14	2021	In the in vitro wound healing model, curcumin upregulated COL1 and EGFR expression via the ERK pathway and increased KGF-1 expression, possibly by an ERK-independent mechanism.	Curcumin	37-45	epidermal growth factor receptor	Homo sapiens	67-71
33003239-14	2021	In the in vitro wound healing model, curcumin upregulated COL1 and EGFR expression via the ERK pathway and increased KGF-1 expression, possibly by an ERK-independent mechanism.	Curcumin	37-45	mitogen-activated protein kinase 1	Homo sapiens	91-94
33003239-14	2021	In the in vitro wound healing model, curcumin upregulated COL1 and EGFR expression via the ERK pathway and increased KGF-1 expression, possibly by an ERK-independent mechanism.	Curcumin	37-45	mitogen-activated protein kinase 1	Homo sapiens	150-153
33376508-9	2021	Curcumin was also revealed to downregulate c-Jun N-terminal kinases (JNK), cytochrome c, caspase-3 and caspase-9 expression upon treatment with 100 and 200 mg/kg curcumin, which may result in inhibition of the mitochondrial apoptotic pathway in renal cells.	Curcumin	162-170	caspase 9	Rattus norvegicus	103-112
33655086-8	2021	Second, curcumin protects from lethal pneumonia and ARDS via targeting NF-kappaB, inflammasome, IL-6 trans signal, and HMGB1 pathways.	Curcumin	8-16	nuclear factor kappa B subunit 1	Homo sapiens	71-80
33655086-8	2021	Second, curcumin protects from lethal pneumonia and ARDS via targeting NF-kappaB, inflammasome, IL-6 trans signal, and HMGB1 pathways.	Curcumin	8-16	interleukin 6	Homo sapiens	96-100
33280258-8	2021	On the contrary, resveratrol and curcumin alone and combination with gemcitabine increased the expression of ABCC2 but decreased cytoplasmic kinases simultaneously.	Curcumin	33-41	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	109-114
33597887-5	2020	After 7 days of continuous curcumin (100 mg/kg/day) administration, the DSS-induced experimental colitis was effectively relieved, with significant decreases in the ratio of day weight to initial body weight, colonic weight, pathological injury score, levels of proinflammatory cytokines IL-7, IL-15, and IL-21, colonic mucosal ulceration, and amount of inflammatory infiltrate.	Curcumin	27-35	interleukin 7	Homo sapiens	288-292
33597887-7	2020	In addition, curcumin significantly inhibited the activation of the JAK1/STAT5 signaling pathway, downregulation of JAK1, STAT5, and p-STAT5 proteins in colon tissue, and upregulation of PIAS1 proteins.	Curcumin	13-21	Janus kinase 1	Homo sapiens	68-72
33597887-7	2020	In addition, curcumin significantly inhibited the activation of the JAK1/STAT5 signaling pathway, downregulation of JAK1, STAT5, and p-STAT5 proteins in colon tissue, and upregulation of PIAS1 proteins.	Curcumin	13-21	Janus kinase 1	Homo sapiens	116-120
33597887-8	2020	These results suggested that curcumin effectively regulated the differentiation of naive, TCM, and TEM cells in the peripheral blood to alleviate DSS-induced experimental colitis, which might be related to the inhibition of JAK1/STAT5 signaling activity.	Curcumin	29-37	Janus kinase 1	Homo sapiens	224-228
33201401-6	2021	Moreover, curcumin treatment alleviated the decrease in mitochondrial membrane potential and the nuclear translocation of cytochrome c induced by copper.	Curcumin	10-18	cytochrome c, somatic	Homo sapiens	122-134
33201401-7	2021	The protein levels of pro-caspase 3, pro-caspase 9, and PARP1 were up-regulated and the Bax/Bcl-2 ratio was down-regulated in the presence of curcumin.	Curcumin	142-150	caspase 3	Homo sapiens	22-35
33201401-5	2021	Further experiments showed that curcumin not only decreased the production of ROS and MDA but also increased the activities of the ROS scavenging enzymes SOD and CAT.	Curcumin	32-40	superoxide dismutase 1	Homo sapiens	154-157
33201401-5	2021	Further experiments showed that curcumin not only decreased the production of ROS and MDA but also increased the activities of the ROS scavenging enzymes SOD and CAT.	Curcumin	32-40	catalase	Homo sapiens	162-165
33201401-7	2021	The protein levels of pro-caspase 3, pro-caspase 9, and PARP1 were up-regulated and the Bax/Bcl-2 ratio was down-regulated in the presence of curcumin.	Curcumin	142-150	poly(ADP-ribose) polymerase 1	Homo sapiens	56-61
33201401-7	2021	The protein levels of pro-caspase 3, pro-caspase 9, and PARP1 were up-regulated and the Bax/Bcl-2 ratio was down-regulated in the presence of curcumin.	Curcumin	142-150	BCL2 associated X, apoptosis regulator	Homo sapiens	88-91
33201401-7	2021	The protein levels of pro-caspase 3, pro-caspase 9, and PARP1 were up-regulated and the Bax/Bcl-2 ratio was down-regulated in the presence of curcumin.	Curcumin	142-150	BCL2 apoptosis regulator	Homo sapiens	92-97
33645034-0	2021	[Curcumin mediates IL-6/STAT3 signaling pathway to repair intestinal mucosal injury induced by 5-FU chemotherapy for colon cancer].	Curcumin	1-9	interleukin 6	Rattus norvegicus	19-23
33645034-1	2021	This study aims to investigate the potential mechanism of curcumin in mediating interleukin-6(IL-6)/signal transducer and activator of transcription 3(STAT3) signaling pathway to repair intestinal mucosal injury induced by 5-fluorouracil(5-FU) chemotherapy for colon cancer.	Curcumin	58-66	interleukin 6	Rattus norvegicus	80-93
33645034-1	2021	This study aims to investigate the potential mechanism of curcumin in mediating interleukin-6(IL-6)/signal transducer and activator of transcription 3(STAT3) signaling pathway to repair intestinal mucosal injury induced by 5-fluorouracil(5-FU) chemotherapy for colon cancer.	Curcumin	58-66	interleukin 6	Rattus norvegicus	94-98
33645034-10	2021	The results showed that, curcumin significantly increased body weight and fecal weight(P<0.05 or P<0.01), decreased fecal score, EB concentration, IL-1beta and TNF-alpha levels(P<0.05 or P<0.01) in rats.	Curcumin	25-33	interleukin 1 alpha	Rattus norvegicus	147-155
33645034-10	2021	The results showed that, curcumin significantly increased body weight and fecal weight(P<0.05 or P<0.01), decreased fecal score, EB concentration, IL-1beta and TNF-alpha levels(P<0.05 or P<0.01) in rats.	Curcumin	25-33	tumor necrosis factor	Rattus norvegicus	160-169
33645034-12	2021	Meanwhile, curcumin could increase the positive expression of occludin, claudin and ZO-1(P<0.05 or P<0.01), repair intestinal barrier function, downregulate the protein expression of IL-6, p-STAT3, vimentin and N-cadherin in jejunum tissues(P<0.05 or P<0.01), and upregulate the protein expression of E-cadherin(P<0.05).	Curcumin	11-19	interleukin 6	Rattus norvegicus	183-187
33645034-13	2021	Therefore, curcumin could repair the intestinal mucosal injury induced by 5-FU chemotherapy for colon cancer, and the mechanism may be related to the inhibition of IL-6/STAT3 signal and the inhibition of epithelial-mesenchymal transition(EMT) process.	Curcumin	11-19	interleukin 6	Rattus norvegicus	164-168
33315037-2	2021	Studies have shown that curcumin (Cur) can protect nerve cells from beta-amyloid (Abeta)-induced mitochondrial damage.	Curcumin	24-32	amyloid beta precursor protein	Homo sapiens	68-88
33315037-2	2021	Studies have shown that curcumin (Cur) can protect nerve cells from beta-amyloid (Abeta)-induced mitochondrial damage.	Curcumin	34-37	amyloid beta precursor protein	Homo sapiens	68-88
33509263-4	2021	METHODS: In this study, we prepared and evaluated a curcumin-hydrogel (cur-hydrogel) to reduce cardiomyocyte apoptosis and reactive oxygen species formation induced by hypoxia-reoxygenation injury, promote autophagy, and reduce mitochondrial damage by maintaining the phosphorylation of Cx43.	Curcumin	52-60	gap junction protein, alpha 1	Rattus norvegicus	287-291
33499881-0	2021	Targeting androgen receptor signaling with MicroRNAs and Curcumin: a promising therapeutic approach for Prostate Cancer Prevention and intervention.	Curcumin	57-65	androgen receptor	Homo sapiens	10-27
33501725-0	2021	Curcumin regulates EZH2/Wnt/beta-Catenin pathway in the mandible and femur of ovariectomized osteoporosis rats.	Curcumin	0-8	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	19-23
33496266-0	2021	Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARalpha signaling pathway.	Curcumin	0-8	peroxisome proliferator activated receptor alpha	Mus musculus	93-102
33496266-5	2021	RNA-sequence analysis revealed that curcumin intake affected hepatic lipid metabolism via the peroxisome proliferator-activated receptor (PPAR) pathway, especially PPARalpha activation, resulting in increased Apoa2 mRNA expression.	Curcumin	36-44	peroxisome proliferator activated receptor alpha	Mus musculus	94-136
33496266-5	2021	RNA-sequence analysis revealed that curcumin intake affected hepatic lipid metabolism via the peroxisome proliferator-activated receptor (PPAR) pathway, especially PPARalpha activation, resulting in increased Apoa2 mRNA expression.	Curcumin	36-44	peroxisome proliferator activated receptor alpha	Mus musculus	138-142
33496266-5	2021	RNA-sequence analysis revealed that curcumin intake affected hepatic lipid metabolism via the peroxisome proliferator-activated receptor (PPAR) pathway, especially PPARalpha activation, resulting in increased Apoa2 mRNA expression.	Curcumin	36-44	peroxisome proliferator activated receptor alpha	Mus musculus	164-173
33496266-7	2021	Taken together, these results demonstrate that curcumin is a PPARalpha activator and may affect expression levels of proteins involved in amyloid deposition to influence amyloidosis and metabolism in a complex manner.	Curcumin	47-55	peroxisome proliferator activated receptor alpha	Mus musculus	61-70
33501725-10	2021	Curcumin inhibited EZH2 mRNA level and induced that of beta-Catenin and Runx2 in the mandible and femur.	Curcumin	0-8	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	19-23
33501725-10	2021	Curcumin inhibited EZH2 mRNA level and induced that of beta-Catenin and Runx2 in the mandible and femur.	Curcumin	0-8	RUNX family transcription factor 2	Rattus norvegicus	72-77
33501725-11	2021	Collectively, curcumin exerts protective effects against OP, possibly by regulating the EZH2/Wnt/beta-Catenin pathway.	Curcumin	14-22	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	88-92
33536913-0	2020	Curcumin Nanoparticle Enhances the Anticancer Effect of Cisplatin by Inhibiting PI3K/AKT and JAK/STAT3 Pathway in Rat Ovarian Carcinoma Induced by DMBA.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	85-88
33542917-9	2020	Acetoside and curcumin were found to inhibit Mpro covalently.	Curcumin	14-22	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	45-49
33527008-0	2021	Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.	Curcumin	22-30	AKT serine/threonine kinase 1	Homo sapiens	58-61
33527008-0	2021	Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.	Curcumin	22-30	mechanistic target of rapamycin kinase	Homo sapiens	62-66
33096358-10	2021	The present study further enriches and perfects the mechanism theory of HgCl2 toxicity and suggest that the CYP450 signaling and Nrf2/HO-1 pathway is important in shedding light on curcumin"s hepatoprotective effects in HgCl2 toxicity.	Curcumin	181-189	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
33183601-3	2021	Composites of GPs with incorporated curcumin showed promising results with the capability to lower symptoms of colitis and significantly decrease the production of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and the activity of MPO, as well.	Curcumin	36-44	tumor necrosis factor	Rattus norvegicus	191-200
33183601-3	2021	Composites of GPs with incorporated curcumin showed promising results with the capability to lower symptoms of colitis and significantly decrease the production of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and the activity of MPO, as well.	Curcumin	36-44	interleukin 1 alpha	Rattus norvegicus	202-210
33506115-8	2021	Curcumin also improved the thiols and the activities of SOD and catalase (P < 0.05, P < 0.01 and P < 0.001).	Curcumin	0-8	catalase	Rattus norvegicus	64-72
33160958-10	2021	Curcumin also increased the expression of proteins involved in neurogenesis (including Ngn2, Pax6 and NeuroD 1) and the Wnt/beta-catenin signaling pathway.	Curcumin	0-8	paired box 6	Mus musculus	93-97
33160958-11	2021	Moreover, the forenamed effects of curcumin were abolished by pretreatment with DKK1, a blocker of Wnt receptor.	Curcumin	35-43	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	80-84
33096358-0	2021	Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway.	Curcumin	0-8	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	75-90
33096358-0	2021	Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	105-109
33096358-5	2021	Additionally, we also found that curcumin could suppress inflammatory damage, unbalance of trace elements (including sodium, magnesium, kalium, calcium overload), oxidative burst induced by HgCl2, which could be associated with cytochrome P450 (CYP450) signaling.	Curcumin	33-41	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	228-243
33096358-7	2021	Furthermore, curcumin significantly increased the nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) and consequently upregulated the expression of heme oxygenase 1 (HO-1) under HgCl2 treatment.	Curcumin	13-21	NFE2 like bZIP transcription factor 2	Homo sapiens	75-109
33096358-7	2021	Furthermore, curcumin significantly increased the nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) and consequently upregulated the expression of heme oxygenase 1 (HO-1) under HgCl2 treatment.	Curcumin	13-21	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
33096358-9	2021	In conclusion, our data identify that curcumin could enhance Nrf2-mediated HO-1 to upregulate antioxidant ability, which might be associate with CYP450 signaling to suppress liver damage induced by HgCl2.	Curcumin	38-46	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65
33183601-3	2021	Composites of GPs with incorporated curcumin showed promising results with the capability to lower symptoms of colitis and significantly decrease the production of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and the activity of MPO, as well.	Curcumin	36-44	interleukin 6	Rattus norvegicus	212-216
33397249-9	2021	Furthermore, the nano-curcumin group compared to the curcumin group demonstrated significant changes (p<0.05) in TC, TG, SOD, MDA and TNF-alpha levels.	Curcumin	22-30	superoxide dismutase 1	Homo sapiens	121-124
33486250-0	2021	Curcumin suppresses cell growth and attenuates fluoride-mediated Caspase-3 activation in ameloblast-like LS8 cells.	Curcumin	0-8	caspase 3	Homo sapiens	65-74
33486250-5	2021	We hypothesized that curcumin attenuates fluoride toxicity through modulation of Ac-p53.	Curcumin	21-29	tumor protein p53	Homo sapiens	84-87
33486250-6	2021	Here we investigated how curcumin affects the p53-p21 pathway in fluoride toxicity.	Curcumin	25-33	tumor protein p53	Homo sapiens	46-49
33486250-8	2021	Curcumin significantly increased phosphorylation of Akt [Thr308] and attenuated fluoride-mediated caspase-3 cleavage and DNA damage marker gammaH2AX expression.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	52-55
33486250-8	2021	Curcumin significantly increased phosphorylation of Akt [Thr308] and attenuated fluoride-mediated caspase-3 cleavage and DNA damage marker gammaH2AX expression.	Curcumin	0-8	caspase 3	Homo sapiens	98-107
33486250-9	2021	Curcumin-mediated attenuation of caspase-3 activation was reversed by Akt inhibitor LY294002 (LY).	Curcumin	0-8	caspase 3	Homo sapiens	33-42
33486250-9	2021	Curcumin-mediated attenuation of caspase-3 activation was reversed by Akt inhibitor LY294002 (LY).	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	70-73
33486250-11	2021	These results suggest that curcumin inhibited fluoride-mediated apoptosis via Akt activation, but DNA damage was suppressed by other pathways.	Curcumin	27-35	AKT serine/threonine kinase 1	Homo sapiens	78-81
33486250-13	2021	However, curcumin itself significantly increased Ac-p53 and upregulated p21 protein levels to suppress cell proliferation in a dose-dependent manner.	Curcumin	9-17	tumor protein p53	Homo sapiens	52-55
33486250-16	2021	These results suggest that curcumin-induced Ac-p53 and p21 led to cell cycle arrest, while curcumin attenuated fluoride-mediated apoptosis via activation of Akt and suppressed fluoride-mediated DNA damage.	Curcumin	27-35	tumor protein p53	Homo sapiens	47-50
33486250-16	2021	These results suggest that curcumin-induced Ac-p53 and p21 led to cell cycle arrest, while curcumin attenuated fluoride-mediated apoptosis via activation of Akt and suppressed fluoride-mediated DNA damage.	Curcumin	91-99	AKT serine/threonine kinase 1	Homo sapiens	157-160
33397249-8	2021	Curcumin and nano-curcumin supplementation also improved significant changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in comparison to the placebo (p<0.05).	Curcumin	0-8	superoxide dismutase 1	Homo sapiens	154-174
33397249-8	2021	Curcumin and nano-curcumin supplementation also improved significant changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in comparison to the placebo (p<0.05).	Curcumin	0-8	superoxide dismutase 1	Homo sapiens	176-179
33397249-8	2021	Curcumin and nano-curcumin supplementation also improved significant changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in comparison to the placebo (p<0.05).	Curcumin	0-8	C-reactive protein	Homo sapiens	232-250
33397249-8	2021	Curcumin and nano-curcumin supplementation also improved significant changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in comparison to the placebo (p<0.05).	Curcumin	0-8	C-reactive protein	Homo sapiens	255-258
33397249-8	2021	Curcumin and nano-curcumin supplementation also improved significant changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in comparison to the placebo (p<0.05).	Curcumin	0-8	interleukin 1 beta	Homo sapiens	261-279
33397249-8	2021	Curcumin and nano-curcumin supplementation also improved significant changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in comparison to the placebo (p<0.05).	Curcumin	0-8	tumor necrosis factor	Homo sapiens	295-322
33397249-8	2021	Curcumin and nano-curcumin supplementation also improved significant changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in comparison to the placebo (p<0.05).	Curcumin	0-8	tumor necrosis factor	Homo sapiens	324-333
33488079-0	2021	Enhanced Photothermal-Photodynamic Therapy by Indocyanine Green and Curcumin-Loaded Layered MoS2 Hollow Spheres via Inhibition of P-Glycoprotein.	Curcumin	68-76	ATP binding cassette subfamily B member 1	Homo sapiens	130-144
33488079-2	2021	In this study, we have prepared and characterized a kind of novel ICG&Cur@MoS2 (ICG and Cur represent indocyanine green and curcumin, respectively) nanoplatform, which can achieve photothermal-photodynamic therapy and inhibit the P-gp effectively and safely.	Curcumin	124-132	ATP binding cassette subfamily B member 1	Homo sapiens	230-234
33435886-9	2021	Curcumin treatment ameliorated peripheral blood cells generation, enhanced SIRT3 activity, decreased SOD2 acetylation, inhibited mROS production, and suppressed iron loading-induced autophagy.	Curcumin	0-8	sirtuin 3	Homo sapiens	75-80
33435886-10	2021	CONCLUSIONS: Our results suggest that curcumin exerts a protective effect on bone marrow by reducing mROS-stimulated autophagic cell death in a manner dependent on the SIRT3/SOD2 pathway.	Curcumin	38-46	sirtuin 3	Homo sapiens	168-173
33430269-7	2021	The curcumin-loaded HA-pNIPAM nanogel showed an anti-proliferative activity against MDA-MB-231, Caco-2, HepG2, HT-29, and TNF-alpha-induced hyperproliferation of keratinocyte (HaCaT) cells.	Curcumin	4-12	tumor necrosis factor	Homo sapiens	122-131
33397249-9	2021	Furthermore, the nano-curcumin group compared to the curcumin group demonstrated significant changes (p<0.05) in TC, TG, SOD, MDA and TNF-alpha levels.	Curcumin	22-30	tumor necrosis factor	Homo sapiens	134-143
33397249-9	2021	Furthermore, the nano-curcumin group compared to the curcumin group demonstrated significant changes (p<0.05) in TC, TG, SOD, MDA and TNF-alpha levels.	Curcumin	53-61	superoxide dismutase 1	Homo sapiens	121-124
33397249-9	2021	Furthermore, the nano-curcumin group compared to the curcumin group demonstrated significant changes (p<0.05) in TC, TG, SOD, MDA and TNF-alpha levels.	Curcumin	53-61	tumor necrosis factor	Homo sapiens	134-143
33747866-1	2021	Purpose: The current study aims to evaluate the in vitro cytotoxic and cell migration effects of synthetic curcumin and its analogues on HER2 and nuclear factor kappa B (NFkappaB) pathways, as well as the in vivo inhibitory effect on cancer growth of metastatic breast cancer.	Curcumin	107-115	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	170-178
33861440-13	2021	This study showed that curcumin has a synergistic effect with metformin in the improvement of insulin resistance and lipid profile in patients with PCOS.	Curcumin	23-31	insulin	Homo sapiens	94-101
33861434-8	2021	The grade of hepatic steatosis, and serum aspartate aminotransferase (AST) levels were significantly reduced in the curcumin group (p = 0.015 and p = 0.007, respectively) compared to the placebo.	Curcumin	116-124	solute carrier family 17 member 5	Homo sapiens	42-68
33747866-1	2021	Purpose: The current study aims to evaluate the in vitro cytotoxic and cell migration effects of synthetic curcumin and its analogues on HER2 and nuclear factor kappa B (NFkappaB) pathways, as well as the in vivo inhibitory effect on cancer growth of metastatic breast cancer.	Curcumin	107-115	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	146-168
33861434-8	2021	The grade of hepatic steatosis, and serum aspartate aminotransferase (AST) levels were significantly reduced in the curcumin group (p = 0.015 and p = 0.007, respectively) compared to the placebo.	Curcumin	116-124	solute carrier family 17 member 5	Homo sapiens	70-73
33861440-2	2021	It has been shown that curcumin also exhibits insulin-sensitizing properties.	Curcumin	23-31	insulin	Homo sapiens	46-53
33861440-3	2021	Given that metformin acts as an ovulation inducing agent and both curcumin and metformin can reduce insulin resistance, the aim of the current study was to evaluate the effect of metformin with and without curcumin nanomicelles in the treatment of women with polycystic ovary syndrome.	Curcumin	66-74	insulin	Homo sapiens	100-107
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	nf-kberk1,2	None	128-139
33202358-10	2021	Curcumin 10 mumol/L treatment maximal promoting the cells viability, ALP activities, mineralization, and levels of Runx2, OC, OPN, Collagen I and EGR-1 in hPDLSCs.	Curcumin	0-8	alkaline phosphatase, placental	Homo sapiens	69-72
33202358-10	2021	Curcumin 10 mumol/L treatment maximal promoting the cells viability, ALP activities, mineralization, and levels of Runx2, OC, OPN, Collagen I and EGR-1 in hPDLSCs.	Curcumin	0-8	RUNX family transcription factor 2	Homo sapiens	115-120
33202358-11	2021	EGR-1 siRNA transfection inversed Curcumin"s promoting effect on ALP activities, mineralization, and levels of Runx2, OC, OPN, Collagen I and EGR-1 in hPDLSCs.	Curcumin	34-42	alkaline phosphatase, placental	Homo sapiens	65-68
33202358-11	2021	EGR-1 siRNA transfection inversed Curcumin"s promoting effect on ALP activities, mineralization, and levels of Runx2, OC, OPN, Collagen I and EGR-1 in hPDLSCs.	Curcumin	34-42	RUNX family transcription factor 2	Homo sapiens	111-116
32777138-6	2021	Besides, 5 muM curcumin treatment inhibited hBM-MSC adipogenic differentiation, but enhanced osteogenic differentiation, which depended on matrix metalloproteinase (MMP)-13 expression and activity.	Curcumin	15-23	matrix metallopeptidase 13	Homo sapiens	139-172
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	141-145
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	thioredoxin interacting protein	Homo sapiens	157-162
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	164-169
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	171-180
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	187-192
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	NLR family pyrin domain containing 3	Homo sapiens	194-199
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	210-214
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	notch receptor 1	Homo sapiens	216-223
33087639-0	2021	Preclinical pharmacokinetics, tissue distribution and primary safety evaluation of a novel curcumin analogue H10 suspension, a potential 17beta hydroxysteroid dehydrogenase type 3 inhibitor.	Curcumin	91-99	hydroxysteroid 17-beta dehydrogenase 3	Homo sapiens	137-179
33087639-2	2021	H10, a novel curcumin analogue, was identified as a potential 17beta-HSD3 inhibitor.	Curcumin	13-21	hydroxysteroid 17-beta dehydrogenase 3	Homo sapiens	62-73
32864863-0	2021	Curcumin induced apoptosis is mediated through oxidative stress in mutated p53 and wild type p53 colon adenocarcinoma cell lines.	Curcumin	0-8	tumor protein p53	Homo sapiens	75-78
32918794-7	2021	However, following all curcumin pretreatment, the serum levels of kidney injury indicators and NGAL were decreased in the urine compared to those in the NS and CMCNa groups (P < .05), whereas renal SOD and CAT activities were increased and MDA was decreased (P < .05).	Curcumin	23-31	catalase	Rattus norvegicus	206-209
32918794-10	2021	Furthermore, iNOS and COX-2 expression and inflammatory factor levels were decreased after curcumin treatment.	Curcumin	91-99	nitric oxide synthase 2	Rattus norvegicus	13-17
32277397-9	2021	Curcumin caused a significant increase in SOD, CAT, and GPX activities including GSH levels with lower production of MDA in kidney homogenates of rats in KBrO3 + CUR.	Curcumin	0-8	catalase	Rattus norvegicus	47-50
31820701-8	2021	Protein interaction network was constructed by cytoscape, and networks of Hsp90, Curcumin and EGC were merged to get common genes involved in Pkcdelta-Nrf2 and Tlr4 pathway.	Curcumin	81-89	NFE2 like bZIP transcription factor 2	Homo sapiens	151-155
31820701-10	2021	Main proteins involved were identified as key regulators in Pkcdelta-Nrf2 and Tlr4 pathway for controlling expression of Hsp90 from Curcumin and EGC in inflammation.	Curcumin	132-140	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
31820701-12	2021	Combinatorial effects of Curcumin and EGC were observed in Pkcdelta-Nrf2 and Tlr4pathway.	Curcumin	25-33	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
32811405-7	2021	RESULTS: The expression of TGF-beta1 gene, vascular number, wound healing rate and the number of fibro blasts increased significantly in adipose tissue-derived stem cells and curcumin nanoliposome groups(p<0.05);the wound surface was also decreased significantly(p<0.05).	Curcumin	175-183	transforming growth factor, beta 1	Rattus norvegicus	27-36
33320772-0	2021	Influence of common dietary supplements (curcumin, andrographolide, and d-limonene) on the radiobiological responses of p53-competent colonic cancer epithelial cells.	Curcumin	41-49	tumor protein p53	Homo sapiens	120-123
33320772-1	2021	PURPOSE: The main goal of the research was to determine whether commercially available common dietary phytochemical supplements (curcumin, andrographolide, and d-limonene) have radiomodulatory effects on p53-competent human colonic epithelial cells.	Curcumin	129-137	tumor protein p53	Homo sapiens	204-207
32864863-0	2021	Curcumin induced apoptosis is mediated through oxidative stress in mutated p53 and wild type p53 colon adenocarcinoma cell lines.	Curcumin	0-8	tumor protein p53	Homo sapiens	93-96
32864863-3	2021	This study evaluates the role of p53 in curcumin mediated ROS generation and cell death.	Curcumin	40-48	tumor protein p53	Homo sapiens	33-36
32864863-9	2021	Our results indicate that curcumin induces ROS mediated cell death in colon adenocarcinoma cell lines and may be mediated via p53.	Curcumin	26-34	tumor protein p53	Homo sapiens	126-129
33017608-8	2021	Besides, Curcumin reduced the nuclear activity of the nuclear factor-kappa B(NF-kappaB), downregulated protein kinase CbetaII (PKCbetaII), NADPH oxidase, and p66Shc, and decreased the activation of p66Shc.	Curcumin	9-17	SHC adaptor protein 1	Rattus norvegicus	158-164
33370686-7	2021	Luna C18 column was used under isocratic conditions to separate curcumin, piperine, and emodin with baseline resolution, and with good separation from other sample components, in as little as 4 min.	Curcumin	64-72	Bardet-Biedl syndrome 9	Homo sapiens	5-8
33017608-0	2021	Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKCbeta/p66Shc axis and activation of FOXO-3a.	Curcumin	0-8	SHC adaptor protein 1	Rattus norvegicus	107-113
33017608-1	2021	This study investigated if the nephroprotective effect of Curcumin in streptozotocin-induced type 1 diabetes mellitus (DM) in rats involves downregulation/inhibition of p66Shc and examined the underlying mechanisms.	Curcumin	58-66	SHC adaptor protein 1	Rattus norvegicus	169-175
33017608-8	2021	Besides, Curcumin reduced the nuclear activity of the nuclear factor-kappa B(NF-kappaB), downregulated protein kinase CbetaII (PKCbetaII), NADPH oxidase, and p66Shc, and decreased the activation of p66Shc.	Curcumin	9-17	SHC adaptor protein 1	Rattus norvegicus	198-204
33017608-6	2021	Mechanistically, Curcumin reduced mRNA and protein levels of collagen I/III and transforming growth factor- beta-1 (TGF-beta1), reduced inflammatory cytokines levels, improved markers of mitochondrial function, and supressed the release of cytochrome-c and the activation of caspase-3.	Curcumin	17-25	transforming growth factor, beta 1	Rattus norvegicus	80-114
33017608-6	2021	Mechanistically, Curcumin reduced mRNA and protein levels of collagen I/III and transforming growth factor- beta-1 (TGF-beta1), reduced inflammatory cytokines levels, improved markers of mitochondrial function, and supressed the release of cytochrome-c and the activation of caspase-3.	Curcumin	17-25	transforming growth factor, beta 1	Rattus norvegicus	116-125
33017608-7	2021	In the kidneys of both control and diabetic rats, Curcumin reduced the levels of reactive oxygen species (ROS), increased mRNA levels of manganese superoxide dismutase (MnSOD) and gamma-glutamyl ligase (GCL-c), increased glutathione (GSH) and protein levels of Bcl-2 and MnSOD, and increased the nuclear levels of nuclear factor2 (Nrf2) and FOXO-3a.	Curcumin	50-58	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	203-208
33017608-7	2021	In the kidneys of both control and diabetic rats, Curcumin reduced the levels of reactive oxygen species (ROS), increased mRNA levels of manganese superoxide dismutase (MnSOD) and gamma-glutamyl ligase (GCL-c), increased glutathione (GSH) and protein levels of Bcl-2 and MnSOD, and increased the nuclear levels of nuclear factor2 (Nrf2) and FOXO-3a.	Curcumin	50-58	BCL2, apoptosis regulator	Rattus norvegicus	261-266
33017608-7	2021	In the kidneys of both control and diabetic rats, Curcumin reduced the levels of reactive oxygen species (ROS), increased mRNA levels of manganese superoxide dismutase (MnSOD) and gamma-glutamyl ligase (GCL-c), increased glutathione (GSH) and protein levels of Bcl-2 and MnSOD, and increased the nuclear levels of nuclear factor2 (Nrf2) and FOXO-3a.	Curcumin	50-58	NFE2 like bZIP transcription factor 2	Rattus norvegicus	331-335
33017608-9	2021	In conclusion, Curcumin prevents kidney damage in diabetic rats by activating Nrf2, inhibiting Nf-kappaB, suppressing NADPH oxidase, and downregulating/inhibiting PKCbetaII/p66Shc axis.	Curcumin	15-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	78-82
33179087-8	2021	Furthermore, curcumin notably decreased the expression levels of epithelial marker E-cadherin and markedly increased the expression levels of mesenchymal marker N-cadherin in MCF-7/TAMR cells compared with the control group.	Curcumin	13-21	cadherin 1	Homo sapiens	83-93
33952798-0	2021	Curcumin promotes cholesterol efflux by regulating ABCA1 expression through miR-125a-5p/SIRT6 axis in THP-1 macrophage to prevent atherosclerosis.	Curcumin	0-8	GLI family zinc finger 2	Homo sapiens	102-107
33952798-1	2021	OBJECTIVE: To seek out the effect of curcumin on cholesterol efflux in THP-1 macrophages and clarify its specific mechanism.	Curcumin	37-45	GLI family zinc finger 2	Homo sapiens	71-76
33952798-8	2021	RESULTS: The optimal dosage of curcumin could reduce foam cell formation and intracellular lipid content, and promote cholesterol efflux in THP-1 macrophages.	Curcumin	31-39	GLI family zinc finger 2	Homo sapiens	140-145
33179078-9	2021	IL-10 level in the colon was significantly increased, while inflammatory cytokines IL-6, IL-17 and IL-23 were significantly reduced following curcumin treatment.	Curcumin	142-150	interleukin 10	Mus musculus	0-5
33179078-9	2021	IL-10 level in the colon was significantly increased, while inflammatory cytokines IL-6, IL-17 and IL-23 were significantly reduced following curcumin treatment.	Curcumin	142-150	interleukin 6	Mus musculus	83-87
33179087-10	2021	Moreover, curcumin treatment for 48 h significantly attenuated H19-induced alterations in N-cadherin and E-cadherin expression levels.	Curcumin	10-18	cadherin 1	Homo sapiens	105-115
33375616-7	2020	Several well-studied drugs can downregulate the expression of TMPRSS2 in human cells, including acetaminophen (paracetamol) and curcumin.	Curcumin	128-136	transmembrane serine protease 2	Homo sapiens	62-69
32281399-7	2021	Common nutritional Nrf2 activators include sulforaphane, curcumin, DATS, quercetin, resveratrol, and EGCG.	Curcumin	57-65	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
32420759-11	2021	Combination of quercetin and curcumin was effective on genes that were particularly related to p53, NF-kappaB and TGF-alpha pathways.	Curcumin	29-37	tumor protein p53	Homo sapiens	95-98
32420759-11	2021	Combination of quercetin and curcumin was effective on genes that were particularly related to p53, NF-kappaB and TGF-alpha pathways.	Curcumin	29-37	nuclear factor kappa B subunit 1	Homo sapiens	100-109
33137599-0	2021	Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial.	Curcumin	11-19	insulin	Homo sapiens	54-61
33137599-3	2021	OBJECTIVE: We hypothesized curcumin to be effective in improving blood sugar levels, insulin resistance and hyperandrogenism in individuals with PCOS.	Curcumin	27-35	insulin	Homo sapiens	85-92
33457406-4	2020	Under simulated hypoxic conditions, curcumin combined with Glu-GNPs can significantly improve the ROS level of MCF-7 and MDA-MB-231 mammospheres; reduce the expression of HIF-1alpha and HSP90, thereby inhibiting the tumor cells" own stress ability; promote the apoptosis of tumor stem cells; and enhance the sensitivity of radiotherapy.	Curcumin	36-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	171-181
31162984-10	2021	Autophagy was enhanced and Akt/mTOR pathway was inhibited by curcumin.	Curcumin	61-69	AKT serine/threonine kinase 1	Rattus norvegicus	27-30
31162984-12	2021	Conclusion: Curcumin may exert its therapeutic effect on SCI through the enhancement of autophagy, in which, inhibition of the Akt/mTOR signaling pathway may be also involved.	Curcumin	12-20	AKT serine/threonine kinase 1	Rattus norvegicus	127-130
32657143-7	2021	Meanwhile, the combination showed a synergistic effect within 48 h. In the curcumin treated group, the expression of Bcl-2 and hTERT genes diminished.	Curcumin	75-83	BCL2 apoptosis regulator	Homo sapiens	117-122
32657143-9	2021	Although all treatments induced apoptosis, the combination of curcumin and metformin showed the maximum level of apoptosis, cytotoxicity, and expression of Bax gene.	Curcumin	62-70	BCL2 associated X, apoptosis regulator	Homo sapiens	156-159
33331220-0	2020	Two polyphenols with diverse mechanisms towards amyloidosis: differential modulation of the fibrillation pathway of human lysozyme by curcumin and EGCG.	Curcumin	134-142	lysozyme	Homo sapiens	122-130
33374783-0	2020	Curcumin Analogue L48H37 Suppresses Human Osteosarcoma U2OS and MG-63 Cells" Migration and Invasion in Culture by Inhibition of uPA via the JAK/STAT Signaling Pathway.	Curcumin	0-8	plasminogen activator, urokinase	Homo sapiens	128-131
33374783-0	2020	Curcumin Analogue L48H37 Suppresses Human Osteosarcoma U2OS and MG-63 Cells" Migration and Invasion in Culture by Inhibition of uPA via the JAK/STAT Signaling Pathway.	Curcumin	0-8	Janus kinase 1	Homo sapiens	140-143
33424997-7	2020	Nevertheless, zinc protoporphyrin (ZnPP), a typical HO-1 inhibitor, significantly reversed the alleviative effect of CUR, THC, and OHC on LPS-stimulated ROS generation.	Curcumin	117-120	heme oxygenase 1	Mus musculus	52-56
33374783-0	2020	Curcumin Analogue L48H37 Suppresses Human Osteosarcoma U2OS and MG-63 Cells" Migration and Invasion in Culture by Inhibition of uPA via the JAK/STAT Signaling Pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	144-148
33350580-9	2020	In conclusion, oral administration of curcumin shows hepatoprotective effects against APAP-overdose induced hepatic damage in normal and gamma-irradiated rats through prospective regulation of the therapeutic targets CYP2E1, Nrf2, and NF-kappaB, via organizing the miR-122 and miR-802 gene expression.	Curcumin	38-46	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	217-223
33350580-9	2020	In conclusion, oral administration of curcumin shows hepatoprotective effects against APAP-overdose induced hepatic damage in normal and gamma-irradiated rats through prospective regulation of the therapeutic targets CYP2E1, Nrf2, and NF-kappaB, via organizing the miR-122 and miR-802 gene expression.	Curcumin	38-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	225-229
33331220-1	2020	The effect of two widely used polyphenols, curcumin and EGCG was investigated on the amyloid fibrillogenesis of the well-characterized model protein human lysozyme (HuL), associated with non-neuropathic systemic amyloidosis, towards exploring their efficacy as modulators of HuL amyloid aggregation and toxicity and unravelling their mechanism of action.	Curcumin	43-51	lysozyme	Homo sapiens	155-163
33337368-0	2021	Computational Evaluation of Interaction Between Curcumin Derivatives and Amyloid-beta Monomers and Fibrils: Relevance to Alzheimer"s Disease.	Curcumin	48-56	amyloid beta precursor protein	Homo sapiens	73-85
33335121-4	2020	In the present study, for the first time, the protective effects of curcumin against PRV-induced oxidative stress, apoptosis, and mitochondrial dysfunction in rat hippocampal neurons and the brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) pathway were investigated.	Curcumin	68-76	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	262-266
33337368-5	2021	OBJECTIVE: To computationally assess the interaction between Abeta peptide and a set of curcumin derivatives previously explored in experimental assays.	Curcumin	88-96	amyloid beta precursor protein	Homo sapiens	61-66
33337368-10	2021	CONCLUSION: Results showed that a single substitution in curcumin improved the interaction of the ligands with the Abeta monomer more so than a double substitution.	Curcumin	57-65	amyloid beta precursor protein	Homo sapiens	115-120
33295851-0	2020	The effects of oral administration of curcumin-galactomannan complex on brain waves are consistent with brain penetration: a randomized, double-blinded, placebo-controlled pilot study.	Curcumin	38-46	amyloid beta precursor protein	Homo sapiens	17-18
33058971-1	2020	In this study, we developed novel complex nanoparticles as carriers for curcumin (Cur) delivery by using soy protein isolate (SPI) and cellulose nanocrystals (CNC) as polymer matrices.	Curcumin	72-80	chromogranin A	Homo sapiens	126-129
33058920-6	2020	Molecular docking and other studies confirmed that curcumin could bind to and upregulate the expression of TET2 and TET3 with hydrogen bonds and arene-H bonds, suggesting that demethylation of RB1 was attributed to reactivation of the demethylation enzymes TET2 and TET3 after curcumin treatment.	Curcumin	51-59	tet methylcytosine dioxygenase 3	Mus musculus	116-120
33058920-6	2020	Molecular docking and other studies confirmed that curcumin could bind to and upregulate the expression of TET2 and TET3 with hydrogen bonds and arene-H bonds, suggesting that demethylation of RB1 was attributed to reactivation of the demethylation enzymes TET2 and TET3 after curcumin treatment.	Curcumin	51-59	tet methylcytosine dioxygenase 3	Mus musculus	266-270
33058920-6	2020	Molecular docking and other studies confirmed that curcumin could bind to and upregulate the expression of TET2 and TET3 with hydrogen bonds and arene-H bonds, suggesting that demethylation of RB1 was attributed to reactivation of the demethylation enzymes TET2 and TET3 after curcumin treatment.	Curcumin	277-285	tet methylcytosine dioxygenase 3	Mus musculus	116-120
33316931-1	2020	The present study evaluates the regulatory effect of Nano-Curcumin (Nano-CUR) against tartrazine (TZ)-induced injuries on apoptosis-related gene expression (i.e., p53, CASP-3 and CASP-9), antioxidant status, and DNA damages in bone marrow in treated rats.	Curcumin	58-66	caspase 9	Rattus norvegicus	179-185
33295851-5	2020	RESULTS: Supplementation of CGM resulted in a significant increase in alpha- and beta-waves (p < 0.05) as well as a significant reduction in alpha/beta ratio in comparison with unformulated curcumin and placebo groups.	Curcumin	190-198	amyloid beta precursor protein	Homo sapiens	19-20
33343370-0	2020	Targeted Delivery of Curcumin to Polyethylene-Induced Osteolysis by Magnetically Guided Zoledronate-Anchored Poly Lactic-Co-Glycolic Acid Nanoparticles via Repressing NF-kappaB Signaling.	Curcumin	21-29	nuclear factor kappa B subunit 1	Homo sapiens	167-176
33201717-10	2020	The cardioprotective effect of CUR was associated with maintenance of cardiac antioxidant enzyme activity and down-regulation of NF-kappaB.	Curcumin	31-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	129-138
33291560-0	2020	Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications.	Curcumin	47-55	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
33291560-4	2020	Curcumin significantly increases the nuclear expression levels and promotes the biological effects of Nrf2 via the interaction with Cys151 in Keap1, which makes it a marvelous therapeutic candidate against a broad range of oxidative stress-related diseases, including type 2 diabetes (T2D), neurodegenerative diseases (NDs), cardiovascular diseases (CVDs), cancers, viral infections, and more recently SARS-CoV-2.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
33291560-4	2020	Curcumin significantly increases the nuclear expression levels and promotes the biological effects of Nrf2 via the interaction with Cys151 in Keap1, which makes it a marvelous therapeutic candidate against a broad range of oxidative stress-related diseases, including type 2 diabetes (T2D), neurodegenerative diseases (NDs), cardiovascular diseases (CVDs), cancers, viral infections, and more recently SARS-CoV-2.	Curcumin	0-8	kelch like ECH associated protein 1	Homo sapiens	142-147
33291560-6	2020	Curcumin potentially opens up new views as possible Nrf2 activator.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	52-56
33291560-8	2020	In this review, we summarized recent studies on the potential effect of curcumin to activate Nrf2 as the design of potential drugs for a viral infection like SARS-Cov2 and acute and chronic inflammation diseases in order to improve the cells" protection.	Curcumin	72-80	NFE2 like bZIP transcription factor 2	Homo sapiens	93-97
33292691-3	2020	There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm.	Curcumin	54-62	NFE2 like bZIP transcription factor 2	Homo sapiens	15-19
32841581-6	2020	Curcumin not only decreased the expression of 14-3-3 proteins but also promoted Bad dephosphorylation in an AKT-dependent fashion.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	108-111
33344438-3	2020	Evidence is increasingly showing that curcumin (CUR) can partly protect cells from Abeta-mediated neurotoxicity by inhibiting Abeta aggregation.	Curcumin	38-46	amyloid beta precursor protein	Homo sapiens	83-88
33344438-3	2020	Evidence is increasingly showing that curcumin (CUR) can partly protect cells from Abeta-mediated neurotoxicity by inhibiting Abeta aggregation.	Curcumin	48-51	amyloid beta precursor protein	Homo sapiens	83-88
33006786-0	2020	Enhanced anti-tumor effects of the PD-1 blockade combined with a highly absorptive form of curcumin targeting STAT3.	Curcumin	91-99	signal transducer and activator of transcription 3	Mus musculus	110-115
33006786-7	2020	The curcumin restored DC functions in xenogeneic nude mouse model implanted with high IL-6 producing human clear cell ovarian cancer cells.	Curcumin	4-12	interleukin 6	Mus musculus	86-90
33006786-9	2020	These results indicate that curcumin augments the induction of tumor antigen-specific T cells by restoring the T cell stimulatory activity of DCs targeting activated STAT3 in both cancer cells and immune cells.	Curcumin	28-36	signal transducer and activator of transcription 3	Mus musculus	166-171
33183576-7	2020	Additionally, curcumin intake upregulated peroxisome proliferator-activated receptor gamma (PPAR-gamma) (P = 0.01).	Curcumin	14-22	peroxisome proliferator activated receptor gamma	Homo sapiens	42-90
33171062-6	2020	Mechanistically, curcumin inactivates the mechanistic target of rapamycin complex 1 (mTORC1), the upstream regulator of rDNA transcription and autophagy induction, by inhibiting mTOR lysosomal localization.	Curcumin	17-25	mechanistic target of rapamycin kinase	Homo sapiens	85-89
32623920-6	2020	We further showed that H2O2-induced oxidative stress was reduced by curcumin via the Nrf2/HO-1 pathway in human neuroblastoma cells.	Curcumin	68-76	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
32623920-7	2020	In addition, we showed that curcumin induced the degradation of amyloidogenic proteins, including amyloid-beta precursor protein and alpha-synuclein, through the TFEB-autophagy/lysosomal pathway.	Curcumin	28-36	amyloid beta precursor protein	Homo sapiens	98-128
33035629-4	2020	The results showed that high-dose curcumin significantly reduced fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, alanine aminotransferase, and aspartate transaminase, liver coefficient, and malondialdehyde levels, and BCL2-Associated X expression in the type 2 diabetes mellitus rats.	Curcumin	34-42	BCL2, apoptosis regulator	Rattus norvegicus	301-305
33035629-5	2020	High-dose curcumin increased the levels of liver superoxide dismutase, catalase, and glutathione; as well as the expression of liver B-cell lymphoma-2, phosphatidylinositol 3-kinase, phosphorylated phosphatidylinositol 3-kinase, protein kinase B, and phosphorylated protein kinase B in type 2 diabetes mellitus rats.	Curcumin	10-18	catalase	Rattus norvegicus	71-79
33129099-10	2020	CONCLUSION: Nano-curcumin, as an anti-inflammatory herbal based agent, may be able to modulate the increased rate of inflammatory cytokines especially IL-1beta and IL-6 mRNA expression and cytokine secretion in COVID-19 patients, which may cause an improvement in clinical manifestation and overall recovery.	Curcumin	17-25	interleukin 6	Homo sapiens	164-168
33489032-0	2020	Curcumin inhibits APOE4-induced injury by activating peroxisome proliferator-activated receptor-gamma (PPARgamma) in SH-SY5Y cells.	Curcumin	0-8	apolipoprotein E	Homo sapiens	18-23
33489032-0	2020	Curcumin inhibits APOE4-induced injury by activating peroxisome proliferator-activated receptor-gamma (PPARgamma) in SH-SY5Y cells.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	53-101
33489032-0	2020	Curcumin inhibits APOE4-induced injury by activating peroxisome proliferator-activated receptor-gamma (PPARgamma) in SH-SY5Y cells.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	103-112
33489032-3	2020	The aim of this study was to investigate the effects of curcumin on APOE4-induced neurological damage and explore its molecular mechanisms.	Curcumin	56-64	apolipoprotein E	Homo sapiens	68-73
33489032-7	2020	Western blot analysis showed that, after transfection with APOE4, the expression of total nuclear factor kappa B (NF-kappaB) p65 and p-NF-kappaB p65 in the nucleus was increased, and curcumin inhibited the nuclear translocation of p65.	Curcumin	183-191	apolipoprotein E	Homo sapiens	59-64
33489032-8	2020	The overexpression of APOE4 inhibited the expression of peroxisome proliferator-activated receptor-gamma (PPARgamma), whereas curcumin reversed and increased the expression of PPARgamma protein.	Curcumin	126-134	peroxisome proliferator activated receptor gamma	Homo sapiens	176-185
33489032-10	2020	Conclusion: This study suggests that APOE4 overexpression can induce cellular inflammatory damage, and pretreatment of curcumin could exert an anti-inflammatory effect by upregulating the expression of PPARgamma to inhibit the activation of NF-kappaB signaling pathway.	Curcumin	119-127	peroxisome proliferator activated receptor gamma	Homo sapiens	202-211
33489032-10	2020	Conclusion: This study suggests that APOE4 overexpression can induce cellular inflammatory damage, and pretreatment of curcumin could exert an anti-inflammatory effect by upregulating the expression of PPARgamma to inhibit the activation of NF-kappaB signaling pathway.	Curcumin	119-127	nuclear factor kappa B subunit 1	Homo sapiens	241-250
33489037-7	2020	The highest SOD activity as well as the lowest MPO and IL-1beta levels were observed in the ADSCs-curcumin-loaded collagen scaffold group.	Curcumin	98-106	interleukin 1 alpha	Rattus norvegicus	55-63
32519340-6	2020	Curcumin affects different molecular pathways such as vascular endothelial growth factors, nuclear factor-kappaB (NF-kappaB), mammalian target of rapamycin, PI3/Akt, microRNAs, and long noncoding RNAs in treatment of lung cancer.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	91-112
32519340-6	2020	Curcumin affects different molecular pathways such as vascular endothelial growth factors, nuclear factor-kappaB (NF-kappaB), mammalian target of rapamycin, PI3/Akt, microRNAs, and long noncoding RNAs in treatment of lung cancer.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	114-123
32519340-6	2020	Curcumin affects different molecular pathways such as vascular endothelial growth factors, nuclear factor-kappaB (NF-kappaB), mammalian target of rapamycin, PI3/Akt, microRNAs, and long noncoding RNAs in treatment of lung cancer.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	126-155
32519340-6	2020	Curcumin affects different molecular pathways such as vascular endothelial growth factors, nuclear factor-kappaB (NF-kappaB), mammalian target of rapamycin, PI3/Akt, microRNAs, and long noncoding RNAs in treatment of lung cancer.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	161-164
32519340-9	2020	Curcumin can elevate the efficacy of radiotherapy in lung cancer therapy by targeting various signaling pathways, such as epidermal growth factor receptor and NF-kappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	159-168
32640496-0	2020	Curcumin inhibits CT26 cells metastasis by decreasing heparanase expression.	Curcumin	0-8	heparanase	Mus musculus	54-64
32640496-1	2020	This study tested the hypothesis that heparanase (HPSE) is related to tumor metastasis and curcumin (CCM) inhibits tumor metastasis by down-regulating HPSE expression.	Curcumin	91-99	heparanase	Mus musculus	151-155
32640496-1	2020	This study tested the hypothesis that heparanase (HPSE) is related to tumor metastasis and curcumin (CCM) inhibits tumor metastasis by down-regulating HPSE expression.	Curcumin	101-104	heparanase	Mus musculus	151-155
32515250-0	2020	Curcumin potentiates laryngeal squamous carcinoma radiosensitivity via NF-KappaB inhibition by suppressing IKKgamma expression.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	71-80
32515250-7	2020	Curcumin suppressed irradiation-induced NF-kappaB activation by suppressing IKKgamma expression, but not IKKalpha and IKKbeta.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	40-49
32515250-11	2020	Additionally, IKKgamma silencing inhibited expression of Bcl-XL, Bcl-2, and cyclin D1.Conclusions: Curcumin enhances LSCC radiosensitivity via NF-KappaB inhibition by suppressing IKKgamma expression.	Curcumin	99-107	BCL2 like 1	Homo sapiens	57-63
32515250-11	2020	Additionally, IKKgamma silencing inhibited expression of Bcl-XL, Bcl-2, and cyclin D1.Conclusions: Curcumin enhances LSCC radiosensitivity via NF-KappaB inhibition by suppressing IKKgamma expression.	Curcumin	99-107	BCL2 apoptosis regulator	Homo sapiens	65-70
32515250-11	2020	Additionally, IKKgamma silencing inhibited expression of Bcl-XL, Bcl-2, and cyclin D1.Conclusions: Curcumin enhances LSCC radiosensitivity via NF-KappaB inhibition by suppressing IKKgamma expression.	Curcumin	99-107	nuclear factor kappa B subunit 1	Homo sapiens	143-152
33093913-2	2020	Since chronic inflammation serves a key role in CTCL progression, curcumin, a natural pigment with proven anti-inflammatory and antineoplastic properties, as well as minimal toxicity, may be used as a therapeutic agent.	Curcumin	66-74	TSPY like 2	Homo sapiens	48-52
33093913-10	2020	Performing western blot analyses of treated and untreated CTCL cells, selective signal transduction changes were recorded for the first time, thus making curcumin nano-formulation an attractive and prospective option with therapeutic relevance for CTCL as a rare orphan disease.	Curcumin	154-162	TSPY like 2	Homo sapiens	58-62
33093913-10	2020	Performing western blot analyses of treated and untreated CTCL cells, selective signal transduction changes were recorded for the first time, thus making curcumin nano-formulation an attractive and prospective option with therapeutic relevance for CTCL as a rare orphan disease.	Curcumin	154-162	TSPY like 2	Homo sapiens	248-252
31854220-5	2020	The expression of MAPK, NF-kappaB, MMP9, MMP2 and vimentin were confirmed by RT-PCR, immunohistochemistry or western blotting.Results: Administration of curcumin significantly inhibited tumour growth, as the tumour weight decreased from 0.67 g (control) to 0.47 g (15 mg/kg) and 0.35 g (30 mg/kg).	Curcumin	153-161	nuclear factor kappa B subunit 1	Homo sapiens	24-33
31854220-6	2020	Curcumin inhibited the expression of PCNA and increased the degree of TUNEL and cleaved caspase-3 staining in tumour tissue.	Curcumin	0-8	caspase 3	Homo sapiens	88-97
31854220-7	2020	The results of western blotting showed that curcumin treatment inhibited NF-kappaB and ERK signalling while activating p38 and JNK.	Curcumin	44-52	nuclear factor kappa B subunit 1	Homo sapiens	73-82
31854220-7	2020	The results of western blotting showed that curcumin treatment inhibited NF-kappaB and ERK signalling while activating p38 and JNK.	Curcumin	44-52	mitogen-activated protein kinase 1	Homo sapiens	87-90
31854220-7	2020	The results of western blotting showed that curcumin treatment inhibited NF-kappaB and ERK signalling while activating p38 and JNK.	Curcumin	44-52	mitogen-activated protein kinase 14	Homo sapiens	119-122
31854220-7	2020	The results of western blotting showed that curcumin treatment inhibited NF-kappaB and ERK signalling while activating p38 and JNK.	Curcumin	44-52	mitogen-activated protein kinase 8	Homo sapiens	127-130
32866059-0	2020	Curcumin attenuates renal interstitial fibrosis of obstructive nephropathy by suppressing epithelial-mesenchymal transition through inhibition of the TLR4/NF-kB and PI3K/AKT signalling pathways.	Curcumin	0-8	toll-like receptor 4	Mus musculus	150-154
32866059-0	2020	Curcumin attenuates renal interstitial fibrosis of obstructive nephropathy by suppressing epithelial-mesenchymal transition through inhibition of the TLR4/NF-kB and PI3K/AKT signalling pathways.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	170-173
32866059-9	2020	Moreover, curcumin reduced the levels of IL-6, IL-1beta and TNF-alpha by 22.5%, 30.3% and 26.7%, respectively, and suppressed vimentin expression in UUO mice.	Curcumin	10-18	interleukin 6	Mus musculus	41-45
32866059-9	2020	Moreover, curcumin reduced the levels of IL-6, IL-1beta and TNF-alpha by 22.5%, 30.3% and 26.7%, respectively, and suppressed vimentin expression in UUO mice.	Curcumin	10-18	tumor necrosis factor	Mus musculus	60-69
32866059-11	2020	In LPS-induced HK-2 cells, curcumin decreased the release of IL-6, IL-1beta and TNF-alpha by 43.4%, 38.1% and 28.3%, respectively.	Curcumin	27-35	interleukin 6	Mus musculus	61-65
32866059-11	2020	In LPS-induced HK-2 cells, curcumin decreased the release of IL-6, IL-1beta and TNF-alpha by 43.4%, 38.1% and 28.3%, respectively.	Curcumin	27-35	tumor necrosis factor	Mus musculus	80-89
32866059-12	2020	In addition, curcumin reduced the expression of TLR4, p-PI3K, p-AKT, p-NF- kappaB and p-IkappaBalpha in both LPS- and TGF-beta1-induced HK-2 cells.	Curcumin	13-21	toll-like receptor 4	Mus musculus	48-52
32866059-12	2020	In addition, curcumin reduced the expression of TLR4, p-PI3K, p-AKT, p-NF- kappaB and p-IkappaBalpha in both LPS- and TGF-beta1-induced HK-2 cells.	Curcumin	13-21	thymoma viral proto-oncogene 1	Mus musculus	64-67
32866059-12	2020	In addition, curcumin reduced the expression of TLR4, p-PI3K, p-AKT, p-NF- kappaB and p-IkappaBalpha in both LPS- and TGF-beta1-induced HK-2 cells.	Curcumin	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-81
32866059-12	2020	In addition, curcumin reduced the expression of TLR4, p-PI3K, p-AKT, p-NF- kappaB and p-IkappaBalpha in both LPS- and TGF-beta1-induced HK-2 cells.	Curcumin	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	88-100
32866059-13	2020	DISCUSSION AND CONCLUSIONS: Curcumin repressed EMT and the inflammatory response by inhibiting the TLR4/NF-kappaB and PI3K/AKT pathways, demonstrating its potential utility in RIF treatment.	Curcumin	28-36	toll-like receptor 4	Mus musculus	99-103
32866059-13	2020	DISCUSSION AND CONCLUSIONS: Curcumin repressed EMT and the inflammatory response by inhibiting the TLR4/NF-kappaB and PI3K/AKT pathways, demonstrating its potential utility in RIF treatment.	Curcumin	28-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	104-113
32866059-13	2020	DISCUSSION AND CONCLUSIONS: Curcumin repressed EMT and the inflammatory response by inhibiting the TLR4/NF-kappaB and PI3K/AKT pathways, demonstrating its potential utility in RIF treatment.	Curcumin	28-36	thymoma viral proto-oncogene 1	Mus musculus	123-126
32628350-0	2020	Curcumin downregulates the PI3K-AKT-mTOR pathway and inhibits growth and progression in head and neck cancer cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	32-35
32628350-0	2020	Curcumin downregulates the PI3K-AKT-mTOR pathway and inhibits growth and progression in head and neck cancer cells.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	36-40
32628350-2	2020	This study aimed to evaluate the effects of curcumin on head and neck cancer (HNC) cell lines and how it modulates the PI3K-AKT-mTOR signaling pathway.	Curcumin	44-52	AKT serine/threonine kinase 1	Homo sapiens	124-127
32628350-2	2020	This study aimed to evaluate the effects of curcumin on head and neck cancer (HNC) cell lines and how it modulates the PI3K-AKT-mTOR signaling pathway.	Curcumin	44-52	mechanistic target of rapamycin kinase	Homo sapiens	128-132
32628350-9	2020	Furthermore, curcumin downregulated the PI3K-AKT-mTOR signaling pathway by modifying the expression of key genes and proteins.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	45-48
32628350-9	2020	Furthermore, curcumin downregulated the PI3K-AKT-mTOR signaling pathway by modifying the expression of key genes and proteins.	Curcumin	13-21	mechanistic target of rapamycin kinase	Homo sapiens	49-53
32628350-10	2020	These findings highlight the promising therapeutic potential of curcumin to inhibit HNC growth and progression and to modulate the PI3K-AKT-mTOR pathway.	Curcumin	64-72	AKT serine/threonine kinase 1	Homo sapiens	136-139
32628350-10	2020	These findings highlight the promising therapeutic potential of curcumin to inhibit HNC growth and progression and to modulate the PI3K-AKT-mTOR pathway.	Curcumin	64-72	mechanistic target of rapamycin kinase	Homo sapiens	140-144
32761362-7	2020	Curcumin increased expression levels of the pro-survival B cell lymphoma extra-large (Bcl-xL) gene and two genes involved in mitochondrial function, peroxisome proliferative-activated receptor-gamma co-activator 1alpha (PGC-1alpha) and mitochondrial transcription factor A (TFAM), in the hippocampus of BDL rats compared with the vehicle-treated sham or BDL rats, while it decreased the pro-apoptotic Bcl-2-associated X protein (Bax) gene expression level.	Curcumin	0-8	PPARG coactivator 1 alpha	Rattus norvegicus	220-230
32761362-9	2020	Furthermore, curcumin reduced the mRNA level of Bax, while it increased Bcl-2 and TFAM mRNA levels.	Curcumin	13-21	BCL2, apoptosis regulator	Rattus norvegicus	72-77
33246423-9	2020	Concomitant with apoptotic induction, epidermal growth factor receptor (EGFR) activation was observed upon curcumin treatment, which was further activated in I227T/N236D mutant transfectant cells when compared with wild-type cells.	Curcumin	107-115	epidermal growth factor receptor	Homo sapiens	38-70
33246423-9	2020	Concomitant with apoptotic induction, epidermal growth factor receptor (EGFR) activation was observed upon curcumin treatment, which was further activated in I227T/N236D mutant transfectant cells when compared with wild-type cells.	Curcumin	107-115	epidermal growth factor receptor	Homo sapiens	72-76
33247374-0	2022	Curcumin Improves Human Umbilical Cord-Derived Mesenchymal Stem Cell Survival via ERK1/2 Signaling and Promotes Motor Outcomes After Spinal Cord Injury.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	82-88
33247374-6	2022	In addition, we showed that the phosphorylation levels of ERK1/2, JNK, and P38 were upregulated in apoptotic hUC-MSCs, while curcumin increased the phosphorylation of ERK1/2 but did not activate JNK or P38, and these effects were reversed by the p42/44 antagonist U0126.	Curcumin	125-133	mitogen-activated protein kinase 8	Homo sapiens	195-198
33247374-6	2022	In addition, we showed that the phosphorylation levels of ERK1/2, JNK, and P38 were upregulated in apoptotic hUC-MSCs, while curcumin increased the phosphorylation of ERK1/2 but did not activate JNK or P38, and these effects were reversed by the p42/44 antagonist U0126.	Curcumin	125-133	mitogen-activated protein kinase 1	Homo sapiens	202-205
33292283-0	2020	Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	73-76
33292283-0	2020	Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer.	Curcumin	13-21	mechanistic target of rapamycin kinase	Homo sapiens	77-81
32462403-13	2020	Furthermore, the pharmacological modulation of this protein by different inhibitors (harmine, curcumine, LDN192960, and ID-8) has enabled to clarify DYRK2 functionality.	Curcumin	94-103	dual specificity tyrosine phosphorylation regulated kinase 2	Homo sapiens	149-154
32204978-2	2020	Curcumin, a compound of the curcuminoid class produced by the Curcuma longa, has been reported to activate nuclear factor erythroid factor 2-related (Nrf2) and inhibit nuclear factor kappa-B (NF-kB).	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
32204978-6	2020	After three months of supplementation, the curcumin group showed a significant decrease in NF-kB mRNA expression (AU) [from 1.08 (0.77-1.38) to 0.52 (0.32-0.95),p = 0.02] and in plasma high sensitivity C-reactive protein (hsCRP) levels [from 3.8 (2.5-6.8) to 2.0 (1.1-3.8) mg/L, p = 0.04].	Curcumin	43-51	C-reactive protein	Homo sapiens	202-220
33183576-7	2020	Additionally, curcumin intake upregulated peroxisome proliferator-activated receptor gamma (PPAR-gamma) (P = 0.01).	Curcumin	14-22	peroxisome proliferator activated receptor gamma	Homo sapiens	92-102
33183576-8	2020	CONCLUSION: Curcumin intake for 12 weeks in patients with T2DM and CHD had beneficial effects on PSQI, TAC, GSH, MDA values, and gene expression of PPAR-gamma.	Curcumin	12-20	peroxisome proliferator activated receptor gamma	Homo sapiens	148-158
33213437-0	2020	The inhibitory effect of curcumin via fascin suppression through JAK/STAT3 pathway on metastasis and recurrence of ovary cancer cells.	Curcumin	25-33	signal transducer and activator of transcription 3	Homo sapiens	69-74
32912630-0	2020	Novel fluorinated derivative of curcumin negatively regulates thioredoxin-interacting protein expression in retinal pigment epithelial and macrophage cells.	Curcumin	32-40	thioredoxin interacting protein	Homo sapiens	62-93
32912630-4	2020	Using a fluorinated-derivative of curcumin (designated Shiga-Y6), we showed significant inhibition of TXNIP mRNA and protein expression, and induction of TRX mRNA and protein in ARPE-19 retinal pigment epithelial cells and THP-1-derived macrophages, while the non-fluorinated structural equivalent (Shiga-Y52) and native curcumin did not show these same effects.	Curcumin	34-42	thioredoxin interacting protein	Homo sapiens	102-107
32912630-4	2020	Using a fluorinated-derivative of curcumin (designated Shiga-Y6), we showed significant inhibition of TXNIP mRNA and protein expression, and induction of TRX mRNA and protein in ARPE-19 retinal pigment epithelial cells and THP-1-derived macrophages, while the non-fluorinated structural equivalent (Shiga-Y52) and native curcumin did not show these same effects.	Curcumin	34-42	GLI family zinc finger 2	Homo sapiens	223-228
33213437-13	2020	Also, curcumin may suppress fascin expression in ovarian cancer cells through STAT3 downregulation.	Curcumin	6-14	signal transducer and activator of transcription 3	Homo sapiens	78-83
33213437-16	2020	CONCLUSIONS: Curcumin reduces fascin expression through JAK/STAT3 pathway inhibition, which interferes with the cellular interactions essential for the metastasis and recurrence of ovarian cancer cells.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	60-65
33052698-3	2020	Various phytoconstituents such as resveratrol (RSV) and curcumin have been found to possess potent anti-inflammatory activity via downregulating the signaling of cytokines (interleukin [IL]-1, IL-6, and tumor necrosis factor alpha) and nuclear factor kappa B signaling.	Curcumin	56-64	interleukin 6	Rattus norvegicus	193-197
33217990-6	2020	Curcumin quenches free radicals, induces antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase), and upregulates antioxidative protein markers-Nrf2 and HO-1 that lead to the suppression of cellular oxidative stress.	Curcumin	0-8	catalase	Homo sapiens	62-70
33217990-6	2020	Curcumin quenches free radicals, induces antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase), and upregulates antioxidative protein markers-Nrf2 and HO-1 that lead to the suppression of cellular oxidative stress.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	165-169
32540526-0	2020	Genipin-crosslinked human serum albumin coating using a tannic acid layer for enhanced oral administration of curcumin in the treatment of ulcerative colitis.	Curcumin	110-118	albumin	Homo sapiens	26-39
32858130-1	2020	The aim of this work was to prepare and characterize inclusion complexes between a synthetic curcumin analog (dibenzalacetone, DBA) and beta-cyclodextrin (beta-CD); and to evaluate their in vitro antileishmanial activity.	Curcumin	93-101	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	155-162
33473285-0	2021	Curcumin inhibits the proteolytic process of SREBP-2 by first inhibiting the expression of S1P rather than directly inhibiting SREBP-2 expression.	Curcumin	0-8	sterol regulatory element binding transcription factor 2	Homo sapiens	45-52
33473285-1	2021	Many studies have demonstrated that curcumin can downregulate mRNA levels of sterol regulatory element-binding proteins (SREBP-2); however, our study did not find similar results.	Curcumin	36-44	sterol regulatory element binding transcription factor 2	Homo sapiens	121-128
33473285-2	2021	This study was designed to demonstrate that curcumin inhibits the proteolytic process of SREBP-2 by first inhibiting the expression of membrane-bound transcription factor site-1 protease (S1P) rather than directly inhibiting SREBP-2 expression.	Curcumin	44-52	sterol regulatory element binding transcription factor 2	Homo sapiens	89-96
33473285-2	2021	This study was designed to demonstrate that curcumin inhibits the proteolytic process of SREBP-2 by first inhibiting the expression of membrane-bound transcription factor site-1 protease (S1P) rather than directly inhibiting SREBP-2 expression.	Curcumin	44-52	sterol regulatory element binding transcription factor 2	Homo sapiens	225-232
33473285-4	2021	After curcumin treatment, SREBP-2 distribution was detected in the cells and S1P protein expression was examined.	Curcumin	6-14	sterol regulatory element binding transcription factor 2	Homo sapiens	26-33
33473285-5	2021	Curcumin could downregulate mRNA levels of SREBP2, SP-1 and SCAP, but it did not simultaneously downregulate the expression of precursor SREBP-2 (pSREBP-2) and SCAP.	Curcumin	0-8	sterol regulatory element binding transcription factor 2	Homo sapiens	43-49
33473285-6	2021	Curcumin can inhibit the proteolytic process of SREBP-2, reduce the production of mature SREBP-2 (mSREBP-2), and change the cellular distribution of SREBP-2.	Curcumin	0-8	sterol regulatory element binding transcription factor 2	Homo sapiens	48-55
33473285-6	2021	Curcumin can inhibit the proteolytic process of SREBP-2, reduce the production of mature SREBP-2 (mSREBP-2), and change the cellular distribution of SREBP-2.	Curcumin	0-8	sterol regulatory element binding transcription factor 2	Homo sapiens	89-96
33473285-6	2021	Curcumin can inhibit the proteolytic process of SREBP-2, reduce the production of mature SREBP-2 (mSREBP-2), and change the cellular distribution of SREBP-2.	Curcumin	0-8	sterol regulatory element binding transcription factor 2	Homo sapiens	89-96
33473285-9	2021	Curcumin can inhibit the SREBP-2 proteolytic process to reduce mSREBP-2 which functions as a transcription factor, affecting the regulation of cholesterol metabolism-related genes.	Curcumin	0-8	sterol regulatory element binding transcription factor 2	Homo sapiens	25-32
33155879-8	2021	The actions of curcumin are achieved by several mechanisms, such as reducing the expression of interleukin (IL)-1, IL-6, IL-12, and tumor necrosis factor-alpha.	Curcumin	15-23	interleukin 6	Homo sapiens	115-119
33155879-8	2021	The actions of curcumin are achieved by several mechanisms, such as reducing the expression of interleukin (IL)-1, IL-6, IL-12, and tumor necrosis factor-alpha.	Curcumin	15-23	tumor necrosis factor	Homo sapiens	132-159
33052698-3	2020	Various phytoconstituents such as resveratrol (RSV) and curcumin have been found to possess potent anti-inflammatory activity via downregulating the signaling of cytokines (interleukin [IL]-1, IL-6, and tumor necrosis factor alpha) and nuclear factor kappa B signaling.	Curcumin	56-64	tumor necrosis factor	Rattus norvegicus	203-230
33152924-7	2020	When curcumin and melatonin were given together, the ameliorative effect was augmented in some of the measured indices e.g. tumor necrosis factor alpha, cystatin C, uric acid, phosphorus in plasma and, urine creatinine and creatinine clearance.	Curcumin	5-13	tumor necrosis factor	Rattus norvegicus	124-151
33065388-5	2020	Docking calculations revealed a high potency of salvianolic acid A and curcumin as Mpro inhibitors with binding energies of -9.7 and -9.2 kcal/mol, respectively.	Curcumin	71-79	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	83-87
33204708-0	2020	Curcumin Improves the Renal Autophagy in Rat Experimental Membranous Nephropathy via Regulating the PI3K/AKT/mTOR and Nrf2/HO-1 Signaling Pathways.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	105-108
33204708-0	2020	Curcumin Improves the Renal Autophagy in Rat Experimental Membranous Nephropathy via Regulating the PI3K/AKT/mTOR and Nrf2/HO-1 Signaling Pathways.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	118-122
33204708-12	2020	Meanwhile, curcumin improved the oxidative stress response by decreasing MDA and increasing SOD, GSH, and CAT levels in the kidney of PHN rats.	Curcumin	11-19	catalase	Rattus norvegicus	106-109
33204708-14	2020	In addition, curcumin downregulated the expression of Bax, Caspase-3, p62, PI3K, p-AKT, and p-mTOR proteins and upregulated the Bcl-2, beclin1, LC3, Nrf2, and HO-1 levels in this animal model.	Curcumin	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	83-86
33204708-14	2020	In addition, curcumin downregulated the expression of Bax, Caspase-3, p62, PI3K, p-AKT, and p-mTOR proteins and upregulated the Bcl-2, beclin1, LC3, Nrf2, and HO-1 levels in this animal model.	Curcumin	13-21	BCL2, apoptosis regulator	Rattus norvegicus	128-133
33204708-14	2020	In addition, curcumin downregulated the expression of Bax, Caspase-3, p62, PI3K, p-AKT, and p-mTOR proteins and upregulated the Bcl-2, beclin1, LC3, Nrf2, and HO-1 levels in this animal model.	Curcumin	13-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	149-153
33204708-15	2020	The results provide a scientific basis that curcumin could significantly alleviate the development of MN by inducing autophagy and alleviating renal oxidative stress through the PI3K/AKT/mTOR and Nrf2/HO-1 pathways.	Curcumin	44-52	AKT serine/threonine kinase 1	Rattus norvegicus	183-186
33204708-15	2020	The results provide a scientific basis that curcumin could significantly alleviate the development of MN by inducing autophagy and alleviating renal oxidative stress through the PI3K/AKT/mTOR and Nrf2/HO-1 pathways.	Curcumin	44-52	NFE2 like bZIP transcription factor 2	Rattus norvegicus	196-200
33147541-1	2020	BACKGROUND: The present study was aimed to evaluate the nano-curcumin supplementation on Th1/Th17 balance by assessment of gene expression and serum level of interferon gamma (IFN-gamma) and interleukin-17 (IL-17) in migraine patients.	Curcumin	61-69	interferon gamma	Homo sapiens	158-185
33147541-4	2020	RESULTS: Compared to placebo group, two month nano-curcumin supplementation led to a significant reduction in serum levels and expression of IL-17 mRNA (P = 0.006 & 0.04, respectively), while there was no statistical difference regarding serum levels and expression of IFN-gamma mRNA.	Curcumin	51-59	interferon gamma	Homo sapiens	269-278
33065388-6	2020	Binding mode analysis demonstrated the ability of salvianolic acid A and curcumin to form nine and six hydrogen bonds, respectively with amino acids proximal to Mpro"s active site.	Curcumin	73-81	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	161-165
32961574-7	2020	Moreover, the inhibitory effects of curcumin on the levels of HIF-1 and HIF-2alpha protein in CS-LCs were investigated using the western blot method.	Curcumin	36-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-67
32961574-10	2020	Based on the results, the curcumin inhibited the expression of HIF-1 by degrading ARNT in CS-LCs.In conclusion, curcumin has inhibitory effects on MCF- 7 cells and CS- LCs and thus may be used as an antitumor agent.	Curcumin	26-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-68
32961574-10	2020	Based on the results, the curcumin inhibited the expression of HIF-1 by degrading ARNT in CS-LCs.In conclusion, curcumin has inhibitory effects on MCF- 7 cells and CS- LCs and thus may be used as an antitumor agent.	Curcumin	112-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-68
32934683-8	2020	These results indicated that the combination of rAd-p53 with curcumin synergistically potentiates apoptosis and inhibit EMT compared with either rAd-p53 or curcumin treatment alone via the regulation of TP53 regulation.	Curcumin	61-69	tumor protein p53	Homo sapiens	203-207
32934683-6	2020	Combined rAd-p53 and curcumin treatment resulted in higher p53 (P<0.01) and p21 (P<0.01) expression compared with rAd-p53 or curcumin were added alone, suggesting an additive effect on TP53 expression.	Curcumin	21-29	tumor protein p53	Homo sapiens	59-62
32934683-6	2020	Combined rAd-p53 and curcumin treatment resulted in higher p53 (P<0.01) and p21 (P<0.01) expression compared with rAd-p53 or curcumin were added alone, suggesting an additive effect on TP53 expression.	Curcumin	21-29	tumor protein p53	Homo sapiens	59-62
32934683-6	2020	Combined rAd-p53 and curcumin treatment resulted in higher p53 (P<0.01) and p21 (P<0.01) expression compared with rAd-p53 or curcumin were added alone, suggesting an additive effect on TP53 expression.	Curcumin	21-29	tumor protein p53	Homo sapiens	185-189
32934683-6	2020	Combined rAd-p53 and curcumin treatment resulted in higher p53 (P<0.01) and p21 (P<0.01) expression compared with rAd-p53 or curcumin were added alone, suggesting an additive effect on TP53 expression.	Curcumin	125-133	tumor protein p53	Homo sapiens	13-16
32934683-7	2020	Additionally, curcumin and rAd-p53 were demonstrated to regulate the activation of mitogen-activated protein kinases (MAPKs) ERK1/2, p38 MAPK and JNK.	Curcumin	14-22	mitogen-activated protein kinase 3	Homo sapiens	125-131
32934683-7	2020	Additionally, curcumin and rAd-p53 were demonstrated to regulate the activation of mitogen-activated protein kinases (MAPKs) ERK1/2, p38 MAPK and JNK.	Curcumin	14-22	mitogen-activated protein kinase 8	Homo sapiens	146-149
32934683-8	2020	These results indicated that the combination of rAd-p53 with curcumin synergistically potentiates apoptosis and inhibit EMT compared with either rAd-p53 or curcumin treatment alone via the regulation of TP53 regulation.	Curcumin	156-164	tumor protein p53	Homo sapiens	203-207
32898599-8	2020	Moreover, curcumin pretreatment significantly up-regulated the expressions of nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1(HO-1) and down-regulated the expressions of nuclear factor- kappaB (NF-kB) and p53 through reduced the nuclear translocation of NF-kB induced by OLA.	Curcumin	10-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-121
32898599-8	2020	Moreover, curcumin pretreatment significantly up-regulated the expressions of nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1(HO-1) and down-regulated the expressions of nuclear factor- kappaB (NF-kB) and p53 through reduced the nuclear translocation of NF-kB induced by OLA.	Curcumin	10-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	123-127
32898599-8	2020	Moreover, curcumin pretreatment significantly up-regulated the expressions of nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1(HO-1) and down-regulated the expressions of nuclear factor- kappaB (NF-kB) and p53 through reduced the nuclear translocation of NF-kB induced by OLA.	Curcumin	10-18	heme oxygenase 1	Mus musculus	133-149
32898599-8	2020	Moreover, curcumin pretreatment significantly up-regulated the expressions of nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1(HO-1) and down-regulated the expressions of nuclear factor- kappaB (NF-kB) and p53 through reduced the nuclear translocation of NF-kB induced by OLA.	Curcumin	10-18	heme oxygenase 1	Mus musculus	150-154
31983246-0	2020	Thymoquinone and Curcumin combination protects cisplatin-induced Kidney Injury, Nephrotoxicity by attenuating NFkB, KIM-1 and ameliorating Nrf2/HO-1 signaling.	Curcumin	17-25	NFE2 like bZIP transcription factor 2	Homo sapiens	139-143
32961025-0	2020	Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1-Foxo1 and PI3K-Akt signalling pathways.	Curcumin	0-8	sirtuin 1	Rattus norvegicus	91-96
32961025-0	2020	Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1-Foxo1 and PI3K-Akt signalling pathways.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	112-115
32961025-9	2020	Curcumin treatment also enhanced phosphorylation of Akt and inhibited acetylation of Foxo1.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	52-55
32961025-10	2020	These results strongly suggest that apoptosis was increased in the heart of diabetic rats, and curcumin played a role in diabetic cardiomyopathy treatment by modulating the Sirt1-Foxo1 and PI3K-Akt pathways.	Curcumin	95-103	sirtuin 1	Rattus norvegicus	173-178
32961025-10	2020	These results strongly suggest that apoptosis was increased in the heart of diabetic rats, and curcumin played a role in diabetic cardiomyopathy treatment by modulating the Sirt1-Foxo1 and PI3K-Akt pathways.	Curcumin	95-103	AKT serine/threonine kinase 1	Rattus norvegicus	194-197
31983246-10	2020	Tq + Cur treatment increased the expressions of phosphorylated Akt, Nrf2 and HO-1 proteins while decreasing the levels of cleaved caspase 3 and NFkB in kidney homogenates.	Curcumin	5-8	AKT serine/threonine kinase 1	Homo sapiens	63-66
31983246-10	2020	Tq + Cur treatment increased the expressions of phosphorylated Akt, Nrf2 and HO-1 proteins while decreasing the levels of cleaved caspase 3 and NFkB in kidney homogenates.	Curcumin	5-8	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
33238792-0	2020	The mechanism of curcumin post-treatment relieving lung injuries by regulating miR-21/TLR4/NF-kappaB signalling pathway.	Curcumin	17-25	toll-like receptor 4	Rattus norvegicus	86-90
31983246-11	2020	In summary, Tq + Cur had protective effects on cisplatin-induced nephrotoxicity and renal injury, which could be mediated by up-regulation of survival signals like Akt, Nrf2/HO-1, and attenuation of KIM-1, NFkB.	Curcumin	17-20	AKT serine/threonine kinase 1	Homo sapiens	164-167
31983246-11	2020	In summary, Tq + Cur had protective effects on cisplatin-induced nephrotoxicity and renal injury, which could be mediated by up-regulation of survival signals like Akt, Nrf2/HO-1, and attenuation of KIM-1, NFkB.	Curcumin	17-20	NFE2 like bZIP transcription factor 2	Homo sapiens	169-173
32499204-0	2020	Clinical effects of the three CFTR potentiator treatments curcumin, genistein and ivacaftor in patients with the CFTR-S1251N gating mutation.	Curcumin	58-66	CF transmembrane conductance regulator	Homo sapiens	30-34
32499204-0	2020	Clinical effects of the three CFTR potentiator treatments curcumin, genistein and ivacaftor in patients with the CFTR-S1251N gating mutation.	Curcumin	58-66	CF transmembrane conductance regulator	Homo sapiens	113-117
32499204-1	2020	BACKGROUND: The natural food supplements curcumin and genistein, and the drug ivacaftor were found effective as CFTR potentiators in the organoids of individuals carrying a S1251N gating mutation, possibly in a synergistic fashion.	Curcumin	41-49	CF transmembrane conductance regulator	Homo sapiens	112-116
32338107-11	2020	At the molecular level, curcumin treatment decreased miR-181a expression level, which was induced by cisplatin and restored the in vivo expression of PTEN, which was suppressed by cisplatin.	Curcumin	24-32	phosphatase and tensin homolog	Mus musculus	150-154
33130987-0	2020	Proinflammatory cytokine profile is critical in autocrine GH-triggered curcumin resistance engulf by atiprimod cotreatment in MCF-7 and MDA-MB-231 breast cancer cells.	Curcumin	71-79	growth hormone 1	Homo sapiens	58-60
33130987-4	2020	We aimed to demonstrate the potential additional effect of atiprimod on curcumin-induced apoptotic cell death via cytokine expression profiles in MCF-7 and MDA-MB-231 cells with active GH signaling.	Curcumin	72-80	growth hormone 1	Homo sapiens	185-187
33130987-9	2020	Autocrine GH-mediated IL-6, IL-8, IL-10 expressions were downregulated by curcumin treatment.	Curcumin	74-82	growth hormone 1	Homo sapiens	10-12
33130987-9	2020	Autocrine GH-mediated IL-6, IL-8, IL-10 expressions were downregulated by curcumin treatment.	Curcumin	74-82	interleukin 6	Homo sapiens	22-26
33130987-9	2020	Autocrine GH-mediated IL-6, IL-8, IL-10 expressions were downregulated by curcumin treatment.	Curcumin	74-82	C-X-C motif chemokine ligand 8	Homo sapiens	28-32
33130987-10	2020	Atiprimod co-treatment increased the inhibitory effect of curcumin on cell viability, proliferation and also increased the curcumin-triggered ROS generation in each GH+ breast cancer cells.	Curcumin	123-131	growth hormone 1	Homo sapiens	165-167
33130987-12	2020	Forced GH-triggered curcumin resistance might be overwhelmed by atiprimod and curcumin co-treatment via modulating NF-kB-mediated inflammatory cytokine expression in MCF-7 and MDA-MB-231 cells.	Curcumin	20-28	growth hormone 1	Homo sapiens	7-9
32891672-5	2020	In addition, our results demonstrated that curcumin alone downregulates the hypoxia-induced expression of HIF-1, GFAP, and NF-H proteins in WMI, whereas riluzole alone and in combination with curcumin remained ineffective in changing the expression of these proteins.	Curcumin	43-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-111
32891672-8	2020	Furthermore, we observed that neuroprotective effects of curcumin and riluzole are mediated through Nrf2/HO-1 signaling.	Curcumin	57-65	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
33142463-6	2020	And the level of caspase 3 protein was significantly upregulated with treating chlorogenic acid, beta-D-Glucan, astragalus polysacharin, astragalus flavone, curcumin, CpG-DNA-2, chicken IgG, LPS, and poly(I:C).	Curcumin	157-165	caspase 3	Homo sapiens	17-26
33149560-8	2020	However, 4 polyphenols such as epigallocatechin gallate (EGCG), homoeriodictyol, isorhamnetin, and curcumin interact, in addition to the Spike protein and its binding sites in GRP78, with the ATPase domain of GRP78.	Curcumin	99-107	heat shock protein family A (Hsp70) member 5	Homo sapiens	176-181
33350211-8	2020	The curcumin TPP-PEG-PCL micelles can significantly reduce the mitochondrial membrane potential of breast cancer cells, increase the release of cytochrome C, significantly increase the expression of pro-apoptotic protein Bcl-2 and reduce the expression of anti-apoptotic Bax protein.	Curcumin	4-12	BCL2 apoptosis regulator	Homo sapiens	221-226
33350211-8	2020	The curcumin TPP-PEG-PCL micelles can significantly reduce the mitochondrial membrane potential of breast cancer cells, increase the release of cytochrome C, significantly increase the expression of pro-apoptotic protein Bcl-2 and reduce the expression of anti-apoptotic Bax protein.	Curcumin	4-12	BCL2 associated X, apoptosis regulator	Homo sapiens	271-274
33103592-5	2022	Here, we report the molecular docking analysis of curcumin and its metabolites with collagenases (MMP-1, MMP-8, MMP-13).	Curcumin	50-58	matrix metallopeptidase 13	Homo sapiens	112-118
33149560-8	2020	However, 4 polyphenols such as epigallocatechin gallate (EGCG), homoeriodictyol, isorhamnetin, and curcumin interact, in addition to the Spike protein and its binding sites in GRP78, with the ATPase domain of GRP78.	Curcumin	99-107	heat shock protein family A (Hsp70) member 5	Homo sapiens	209-214
33178666-3	2020	Curcumin inhibits Bcl-2, Bcl-XL, VEGF, c-Myc, ICAM-1, EGFR, STAT3 phosphorylation, and cyclin D1 genes involved in the various stages of breast, prostate, and gastric cancer proliferation, angiogenesis, invasion, and metastasis.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	54-58
33178666-3	2020	Curcumin inhibits Bcl-2, Bcl-XL, VEGF, c-Myc, ICAM-1, EGFR, STAT3 phosphorylation, and cyclin D1 genes involved in the various stages of breast, prostate, and gastric cancer proliferation, angiogenesis, invasion, and metastasis.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	18-23
33178666-3	2020	Curcumin inhibits Bcl-2, Bcl-XL, VEGF, c-Myc, ICAM-1, EGFR, STAT3 phosphorylation, and cyclin D1 genes involved in the various stages of breast, prostate, and gastric cancer proliferation, angiogenesis, invasion, and metastasis.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	60-65
33178666-3	2020	Curcumin inhibits Bcl-2, Bcl-XL, VEGF, c-Myc, ICAM-1, EGFR, STAT3 phosphorylation, and cyclin D1 genes involved in the various stages of breast, prostate, and gastric cancer proliferation, angiogenesis, invasion, and metastasis.	Curcumin	0-8	BCL2 like 1	Homo sapiens	25-31
32763387-2	2020	Curcumin has been indicated as a promising active agent with a variety of pharmacological activities, including a potential ability to treat brain tumors, traumatic brain injury, and CNS disorders, such as Alzheimer"s disease, as it may inhibit amyloid-beta-protein (Abeta) aggregation and Abeta-induced inflammation.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	267-272
33178666-3	2020	Curcumin inhibits Bcl-2, Bcl-XL, VEGF, c-Myc, ICAM-1, EGFR, STAT3 phosphorylation, and cyclin D1 genes involved in the various stages of breast, prostate, and gastric cancer proliferation, angiogenesis, invasion, and metastasis.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	33-37
32763387-2	2020	Curcumin has been indicated as a promising active agent with a variety of pharmacological activities, including a potential ability to treat brain tumors, traumatic brain injury, and CNS disorders, such as Alzheimer"s disease, as it may inhibit amyloid-beta-protein (Abeta) aggregation and Abeta-induced inflammation.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	290-295
32822714-8	2020	Curcumin, quercetin, and atorvastatin treatment lead to down-regulation of miR-21 and TGFbeta1 and up-regulation of miR-122 in the BDL groups.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	86-94
33224436-10	2020	The expression of Bcl2 and caspase-3 was improved associated with downregulation of AT1R in curcumin treated groups.	Curcumin	92-100	BCL2, apoptosis regulator	Rattus norvegicus	18-22
32822714-0	2020	Effect of Atorvastatin, Curcumin, and Quercetin on miR-21 and miR-122 and their correlation with TGFbeta1 expression in experimental liver fibrosis.	Curcumin	24-32	transforming growth factor, beta 1	Rattus norvegicus	97-105
33083489-0	2020	Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL-1beta, and TNF-alpha in Chronic Periodontitis Patients.	Curcumin	12-20	tumor necrosis factor	Homo sapiens	67-76
33083489-2	2020	The study is aimed at evaluating the effect of curcumin gel on serum levels of micronutrients (zinc, copper, and magnesium) and proinflammatory cytokines (IL-1beta and TNF-alpha) in chronic periodontitis patients.	Curcumin	47-55	tumor necrosis factor	Homo sapiens	168-177
32767015-5	2020	To optimize the optical property of the NPs, CPM and curcumin, which were introduced as the Forster resonance energy transfer (FRET) donor and acceptor, respectively, were co-encapsulated, and bright green CPM@Cur NPs with large stokes shift and narrow emission band width were constructed.	Curcumin	53-61	carboxypeptidase M	Mus musculus	206-209
32479931-2	2020	In this study, the inclusion complex of curcumin (CUR), as a model anticancer compound, with beta-CD was prepared and we constructed an antibody-enzyme bioconjugate (dextran mediated MAase-Trastuzumab bioconjugate) for controlled and targeted release of CUR at HER2 positive cancer cells (including SKBR3 and BT474).	Curcumin	40-48	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	93-100
32892656-2	2020	This study aimed to encapsulate two natural-based drugs, curcumin (CUR) and piperine (PIP) into highly biocompatible albumin nanoparticles for anticancer applications.Significance: A simultaneous exertion of CUR and PIP in a biocompatible drug delivery system with the minimum side effects and no limitations was achievable in this work for cancer treatment.Methods: Curcumin-piperine-loaded human serum albumin nanoparticles (CUR-PIP-HSA-NPs) were synthesized by the self-assembly method.	Curcumin	208-211	albumin	Homo sapiens	398-411
32479931-2	2020	In this study, the inclusion complex of curcumin (CUR), as a model anticancer compound, with beta-CD was prepared and we constructed an antibody-enzyme bioconjugate (dextran mediated MAase-Trastuzumab bioconjugate) for controlled and targeted release of CUR at HER2 positive cancer cells (including SKBR3 and BT474).	Curcumin	40-48	erb-b2 receptor tyrosine kinase 2	Homo sapiens	261-265
33025506-15	2020	Concentration dependent alleviation of chemoresistance development by curcumin was confirmed and was found to reduce gene level expression of P-glycoprotein and Cox-2.	Curcumin	70-78	ATP binding cassette subfamily B member 1	Homo sapiens	142-156
32924710-0	2020	Curcumin improves necrotising microscopic colitis and cell pyroptosis by activating SIRT1/NRF2 and inhibiting the TLR4 signalling pathway in newborn rats.	Curcumin	0-8	sirtuin 1	Rattus norvegicus	84-89
32924710-0	2020	Curcumin improves necrotising microscopic colitis and cell pyroptosis by activating SIRT1/NRF2 and inhibiting the TLR4 signalling pathway in newborn rats.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	90-94
32924710-0	2020	Curcumin improves necrotising microscopic colitis and cell pyroptosis by activating SIRT1/NRF2 and inhibiting the TLR4 signalling pathway in newborn rats.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	114-118
32924710-7	2020	Furthermore, the SIRT1/NRF2 pathway was inhibited in the intestinal tissue of NEC newborn rats, whereas curcumin treatment induced the activation of the SIRT1/NRF2 pathway and inhibited TLR4 expression in these animals.	Curcumin	104-112	sirtuin 1	Rattus norvegicus	153-158
32924710-7	2020	Furthermore, the SIRT1/NRF2 pathway was inhibited in the intestinal tissue of NEC newborn rats, whereas curcumin treatment induced the activation of the SIRT1/NRF2 pathway and inhibited TLR4 expression in these animals.	Curcumin	104-112	NFE2 like bZIP transcription factor 2	Rattus norvegicus	159-163
32924710-7	2020	Furthermore, the SIRT1/NRF2 pathway was inhibited in the intestinal tissue of NEC newborn rats, whereas curcumin treatment induced the activation of the SIRT1/NRF2 pathway and inhibited TLR4 expression in these animals.	Curcumin	104-112	toll-like receptor 4	Rattus norvegicus	186-190
32924710-8	2020	In addition, curcumin could also inhibit the expression of inflammatory factors and alleviate the LPS/ATP-induced focal death pathway in intestinal epithelial cells through the SIRT1 pathway.	Curcumin	13-21	sirtuin 1	Rattus norvegicus	177-182
32924710-9	2020	Curcumin can improve necrotising microscopic colitis and cell pyroptosis by attenuating NEC-induced inhibition of SIRT1/NRF2 and inhibiting the TLR4 signalling pathway in newborn rats.	Curcumin	0-8	sirtuin 1	Rattus norvegicus	114-119
32924710-9	2020	Curcumin can improve necrotising microscopic colitis and cell pyroptosis by attenuating NEC-induced inhibition of SIRT1/NRF2 and inhibiting the TLR4 signalling pathway in newborn rats.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	120-124
32924710-9	2020	Curcumin can improve necrotising microscopic colitis and cell pyroptosis by attenuating NEC-induced inhibition of SIRT1/NRF2 and inhibiting the TLR4 signalling pathway in newborn rats.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	144-148
32399774-0	2020	Curcumin suppressed proliferation and migration of human retinoblastoma cells through modulating NF-kappaB pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	97-106
32399774-6	2020	Protein expressions of MMP-2, MMP-9 and VEGF in the WERI-Rb-1 cells were also significantly inhibited by curcumin in a concentration-dependent manner (0-40 microM).	Curcumin	105-113	vascular endothelial growth factor A	Homo sapiens	40-44
32399774-7	2020	Furthermore, nuclear translocation of NF-kappaB (p65) was significantly inhibited by curcumin in time-dependent manner (6-24 h).	Curcumin	85-93	nuclear factor kappa B subunit 1	Homo sapiens	38-47
32399774-8	2020	CONCLUSION: Curcumin inhibited proliferation and migration of WERI-Rb-1 cells, a cell line of human retinoblastoma, which might be through modulating NF-kappaB and its downstream proteins including VEGF, MMP-2, and MMP-9.	Curcumin	12-20	nuclear factor kappa B subunit 1	Homo sapiens	150-159
32399774-8	2020	CONCLUSION: Curcumin inhibited proliferation and migration of WERI-Rb-1 cells, a cell line of human retinoblastoma, which might be through modulating NF-kappaB and its downstream proteins including VEGF, MMP-2, and MMP-9.	Curcumin	12-20	vascular endothelial growth factor A	Homo sapiens	198-202
33025506-15	2020	Concentration dependent alleviation of chemoresistance development by curcumin was confirmed and was found to reduce gene level expression of P-glycoprotein and Cox-2.	Curcumin	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	161-166
32060973-3	2020	In the present study, we found that curcumin reversed the phenotype of CAFs to that of peri-tumor fibroblasts (PTFs)-like cells by downregulating the expression of alpha-SMA (a special marker for CAFs) and inhibiting the secretion of pro-carcinogenic cytokines, including transforming growth factor-beta1 (TGF-beta1), matrix metalloproteinases 2 (MMP2), and stromal cell-derived factor-1 (SDF-1).	Curcumin	36-44	actin alpha 1, skeletal muscle	Homo sapiens	164-173
32060973-3	2020	In the present study, we found that curcumin reversed the phenotype of CAFs to that of peri-tumor fibroblasts (PTFs)-like cells by downregulating the expression of alpha-SMA (a special marker for CAFs) and inhibiting the secretion of pro-carcinogenic cytokines, including transforming growth factor-beta1 (TGF-beta1), matrix metalloproteinases 2 (MMP2), and stromal cell-derived factor-1 (SDF-1).	Curcumin	36-44	transforming growth factor beta 1	Homo sapiens	272-304
32060973-3	2020	In the present study, we found that curcumin reversed the phenotype of CAFs to that of peri-tumor fibroblasts (PTFs)-like cells by downregulating the expression of alpha-SMA (a special marker for CAFs) and inhibiting the secretion of pro-carcinogenic cytokines, including transforming growth factor-beta1 (TGF-beta1), matrix metalloproteinases 2 (MMP2), and stromal cell-derived factor-1 (SDF-1).	Curcumin	36-44	transforming growth factor beta 1	Homo sapiens	306-315
32307773-4	2020	Numerous studies have shown that curcumin delays the initiation and progression of NSCLC by affecting a wide range of molecular targets and cell signalling pathways including NF-kB, Akt, MAPKS, BCL-2, ROS and microRNAs (miRNAs).	Curcumin	33-41	AKT serine/threonine kinase 1	Homo sapiens	182-185
31768967-0	2020	PARP inhibitor Olaparib Enhances the Apoptotic Potentiality of Curcumin by Increasing the DNA Damage in Oral Cancer Cells through Inhibition of BER Cascade.	Curcumin	63-71	poly(ADP-ribose) polymerase 1	Homo sapiens	0-4
32307773-4	2020	Numerous studies have shown that curcumin delays the initiation and progression of NSCLC by affecting a wide range of molecular targets and cell signalling pathways including NF-kB, Akt, MAPKS, BCL-2, ROS and microRNAs (miRNAs).	Curcumin	33-41	BCL2 apoptosis regulator	Homo sapiens	194-199
32718261-6	2020	Moreover, treatment with PE and/or curcumin exerted a significant upregulation of Nrf2/HO-1 gene expressions along with significant downregulation of NF-kB, TGF-beta, and phospho-Smad3 protein expressions, as well as alpha-SMA and collagen-1 gene expressions.	Curcumin	35-43	NFE2 like bZIP transcription factor 2	Rattus norvegicus	82-86
32814232-8	2020	RESULTS: We found that punicalagin and curcumin significantly supressed TNF-induced pro-inflammatory cytokine (IL1A, IL1B, and IL6) and chemokine (CCL2-4, CXCL1, CXCL5 and CXCL8) expression in human placenta, VAT and SAT.	Curcumin	39-47	tumor necrosis factor	Homo sapiens	72-75
32814232-8	2020	RESULTS: We found that punicalagin and curcumin significantly supressed TNF-induced pro-inflammatory cytokine (IL1A, IL1B, and IL6) and chemokine (CCL2-4, CXCL1, CXCL5 and CXCL8) expression in human placenta, VAT and SAT.	Curcumin	39-47	interleukin 1 beta	Homo sapiens	117-121
32814232-8	2020	RESULTS: We found that punicalagin and curcumin significantly supressed TNF-induced pro-inflammatory cytokine (IL1A, IL1B, and IL6) and chemokine (CCL2-4, CXCL1, CXCL5 and CXCL8) expression in human placenta, VAT and SAT.	Curcumin	39-47	interleukin 6	Homo sapiens	127-130
32814232-8	2020	RESULTS: We found that punicalagin and curcumin significantly supressed TNF-induced pro-inflammatory cytokine (IL1A, IL1B, and IL6) and chemokine (CCL2-4, CXCL1, CXCL5 and CXCL8) expression in human placenta, VAT and SAT.	Curcumin	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	172-177
32814232-9	2020	Anti-inflammatory cytokine IL4 and IL13 mRNA expression was also upregulated by punicalagin and curcumin treatment in placenta, VAT and SAT.	Curcumin	96-104	interleukin 4	Homo sapiens	27-30
32814232-9	2020	Anti-inflammatory cytokine IL4 and IL13 mRNA expression was also upregulated by punicalagin and curcumin treatment in placenta, VAT and SAT.	Curcumin	96-104	interleukin 13	Homo sapiens	35-39
32814232-10	2020	Punicalagin and curcumin also altered antioxidant (SOD2 and catalase) mRNA expression in placenta, VAT and SAT, with minimal effect on hydrogen peroxide concentrations in tissue lysates.	Curcumin	16-24	catalase	Homo sapiens	60-68
32718261-0	2020	Combination of pomegranate extract and curcumin ameliorates thioacetamide-induced liver fibrosis in rats: Impact on TGF-beta/Smad3 and NF-kappaB signaling pathways.	Curcumin	39-47	SMAD family member 3	Rattus norvegicus	125-130
32718261-5	2020	The results indicated that PE and/or curcumin attenuated TAA-induced liver fibrogenesis, as evidenced by significant improvement in the liver function tests (AST, ALT, ALP, and albumin), oxidative stress biomarkers (MDA, SOD, and GSH), and inflammatory biomarkers (NF-kB, TNF-alpha, IL-1beta, iNOS, TGF-beta, and MPO), compared to TAA group.	Curcumin	37-45	tumor necrosis factor	Rattus norvegicus	272-281
32718261-5	2020	The results indicated that PE and/or curcumin attenuated TAA-induced liver fibrogenesis, as evidenced by significant improvement in the liver function tests (AST, ALT, ALP, and albumin), oxidative stress biomarkers (MDA, SOD, and GSH), and inflammatory biomarkers (NF-kB, TNF-alpha, IL-1beta, iNOS, TGF-beta, and MPO), compared to TAA group.	Curcumin	37-45	interleukin 1 alpha	Rattus norvegicus	283-291
32718261-5	2020	The results indicated that PE and/or curcumin attenuated TAA-induced liver fibrogenesis, as evidenced by significant improvement in the liver function tests (AST, ALT, ALP, and albumin), oxidative stress biomarkers (MDA, SOD, and GSH), and inflammatory biomarkers (NF-kB, TNF-alpha, IL-1beta, iNOS, TGF-beta, and MPO), compared to TAA group.	Curcumin	37-45	nitric oxide synthase 2	Rattus norvegicus	293-297
32718261-6	2020	Moreover, treatment with PE and/or curcumin exerted a significant upregulation of Nrf2/HO-1 gene expressions along with significant downregulation of NF-kB, TGF-beta, and phospho-Smad3 protein expressions, as well as alpha-SMA and collagen-1 gene expressions.	Curcumin	35-43	SMAD family member 3	Rattus norvegicus	179-184
32718261-8	2020	In conclusion, hepatoprotective activities of PE and/or curcumin could be linked to their abilities to modulate Nrf2/HO-1, NF-kappaB, and TGF-beta/Smad3 signaling pathways.	Curcumin	56-64	NFE2 like bZIP transcription factor 2	Rattus norvegicus	112-116
32718261-8	2020	In conclusion, hepatoprotective activities of PE and/or curcumin could be linked to their abilities to modulate Nrf2/HO-1, NF-kappaB, and TGF-beta/Smad3 signaling pathways.	Curcumin	56-64	SMAD family member 3	Rattus norvegicus	147-152
32996021-8	2021	Therefore, curcumin-mediated aPDT activated Bcl-2 apoptosis signaling pathways in mouse fibroblasts regarding present conditions, reducing the viability of cells with the increase of curcumin concentrations and light energies.	Curcumin	11-19	B cell leukemia/lymphoma 2	Mus musculus	44-49
32996021-8	2021	Therefore, curcumin-mediated aPDT activated Bcl-2 apoptosis signaling pathways in mouse fibroblasts regarding present conditions, reducing the viability of cells with the increase of curcumin concentrations and light energies.	Curcumin	183-191	B cell leukemia/lymphoma 2	Mus musculus	44-49
33061449-0	2020	Curcumin Negatively Regulates Cigarette Smoke-Induced Renal Cell Carcinoma Epithelial-Mesenchymal Transition Through the ERK5/AP-1 Pathway.	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	126-130
33062432-0	2020	Explicating anti-amyloidogenic role of curcumin and piperine via amyloid beta (Abeta) explicit pathway: recovery and reversal paradigm effects.	Curcumin	39-47	amyloid beta precursor protein	Homo sapiens	65-77
33062432-0	2020	Explicating anti-amyloidogenic role of curcumin and piperine via amyloid beta (Abeta) explicit pathway: recovery and reversal paradigm effects.	Curcumin	39-47	amyloid beta precursor protein	Homo sapiens	79-84
33062432-9	2020	We revealed that curcumin and piperine have displayed their actions against Abeta via the modulation of various mechanistic pathways.	Curcumin	17-25	amyloid beta precursor protein	Homo sapiens	76-81
33062432-10	2020	Alterations in expression profiles of genes in the neuronal cell model may explain Abeta pathology post-treatment and provide new insights for remedial approaches of a combined treatment using curcumin and piperine.	Curcumin	193-201	amyloid beta precursor protein	Homo sapiens	83-88
33061449-11	2020	Furthermore, curcumin showed the same inhibitory effect as XMD8-92 and significantly reversed CS-induced EMT through inhibiting the ERK5/AP-1 signaling pathway.	Curcumin	13-21	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	137-141
32948186-8	2020	The results of Annexin V-FITC/PI, JC-1, Western blot and ROS analysis showed that the expression of cleaved caspase-3 and Bax were up-regulated Bcl-2 was down-regulated in Cepharanthine or Curcumin treated groups, while ROS and MMP value were decreased at different degrees and the apoptosis rate was reduced.	Curcumin	189-197	caspase 3	Homo sapiens	108-117
33046993-8	2020	Our results showed that curcumin induced ROS accumulation, apoptosis, autophagy, cell cycle arrest, and cellular senescence accompanied by upregulation of p53 and p21 proteins in SiHa cells.	Curcumin	24-32	tumor protein p53	Homo sapiens	155-158
33029254-2	2020	Retinal amyloid beta (Abeta) can be labeled by curcumin.	Curcumin	47-55	amyloid beta precursor protein	Homo sapiens	22-27
32948186-8	2020	The results of Annexin V-FITC/PI, JC-1, Western blot and ROS analysis showed that the expression of cleaved caspase-3 and Bax were up-regulated Bcl-2 was down-regulated in Cepharanthine or Curcumin treated groups, while ROS and MMP value were decreased at different degrees and the apoptosis rate was reduced.	Curcumin	189-197	BCL2 associated X, apoptosis regulator	Homo sapiens	122-125
32948186-8	2020	The results of Annexin V-FITC/PI, JC-1, Western blot and ROS analysis showed that the expression of cleaved caspase-3 and Bax were up-regulated Bcl-2 was down-regulated in Cepharanthine or Curcumin treated groups, while ROS and MMP value were decreased at different degrees and the apoptosis rate was reduced.	Curcumin	189-197	BCL2 apoptosis regulator	Homo sapiens	144-149
32945310-5	2020	The homemade curcumin analog (CA) was encapsulated by alpha-lactalbumin (alpha-LA), and the Treg cell specific antibody (mAb), as a therapeutic agent, was linked to the drug-loaded protein via matrix metalloproteinase-responded peptide (P).	Curcumin	13-21	lactalbumin alpha	Homo sapiens	54-71
33014280-0	2020	Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	152-156
32957726-12	2020	In contrast, suppression of ABCG2 expression by curcumin and tea polyphenol EGCG led to greater PpIX accumulation and enhanced PDT treatment efficiency in OC cells.	Curcumin	48-56	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	28-33
32640441-7	2020	It has been shown that PLLA films are suitable for entrapment of curcumin (up to 12.1 mum cm-2) and provide its sustained release in solutions isotonic to blood plasma.	Curcumin	65-73	latexin	Homo sapiens	86-89
32942739-3	2020	Curcumin (CU) is a well-known inhibitor of the aggregation of amyloid-beta (Abeta) peptides.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	62-74
32942739-3	2020	Curcumin (CU) is a well-known inhibitor of the aggregation of amyloid-beta (Abeta) peptides.	Curcumin	10-12	amyloid beta precursor protein	Homo sapiens	62-74
32335119-0	2020	Curcumin-human serum albumin nanoparticles decorated with PDL1 binding peptide for targeting PDL1-expressing breast cancer cells.	Curcumin	0-8	albumin	Homo sapiens	15-28
32335119-2	2020	Human serum albumin-curcumin nanoparticles (HSA/Cur NP) were first prepared by desolvation method and then functionalized with PDL1 binding peptide.	Curcumin	20-28	albumin	Homo sapiens	12-19
32634426-9	2020	Also, in chemoresistance gastric cancer cells, co-administration of curcumin reduced chemoresistance mainly through the reduction of NF-kappaB activation and elevation of apoptosis.	Curcumin	68-76	nuclear factor kappa B subunit 1	Homo sapiens	133-142
32621921-0	2020	Curcumin inhibits the formation of atherosclerosis in ApoE-/- mice by suppressing cytomegalovirus activity in endothelial cells.	Curcumin	0-8	apolipoprotein E	Mus musculus	54-58
32464315-0	2020	Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.	Curcumin	0-8	insulin	Homo sapiens	74-81
32464315-0	2020	Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.	Curcumin	0-8	insulin	Homo sapiens	118-125
32464315-0	2020	Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.	Curcumin	49-57	insulin	Homo sapiens	74-81
32464315-0	2020	Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.	Curcumin	49-57	insulin	Homo sapiens	118-125
32464315-5	2020	AIM OF THE STUDY: Our study identified the functional contribution of the metabolites of CUR and the related molecular mechanism in improving insulin sensitivity.	Curcumin	89-92	insulin	Homo sapiens	142-149
32938017-6	2020	To date, fewer than twenty phytochemicals have been reported as NRF2 epigenetic modifiers, including curcumin, sulforaphane, resveratrol, reserpine, and ursolic acid.	Curcumin	101-109	nuclear factor, erythroid derived 2, like 2	Mus musculus	64-68
32074070-0	2020	Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway.	Curcumin	0-8	microRNA 206	Homo sapiens	102-109
32891174-9	2020	This cytotoxic effect of nano-curcumin against pancreatic adenocarcinoma was achieved through provoking the production of intracellular reactive oxygen species and activating endoplasmic reticulum stress, which leads to enhanced cell apoptosis via decreased phosphorylation of signal transducer and activator of transcription 3.	Curcumin	30-38	signal transducer and activator of transcription 3	Homo sapiens	277-327
32893845-11	2020	The expression levels of N-cadherin, Vimentin, Wnt3a, Snail1, and Twist, as well as the nuclear translocation levels of ss-catenin, were reduced in a curcumin concentration-dependent manner.	Curcumin	150-158	snail family transcriptional repressor 1	Homo sapiens	54-60
32893845-11	2020	The expression levels of N-cadherin, Vimentin, Wnt3a, Snail1, and Twist, as well as the nuclear translocation levels of ss-catenin, were reduced in a curcumin concentration-dependent manner.	Curcumin	150-158	twist family bHLH transcription factor 1	Homo sapiens	66-71
32893845-12	2020	The expression levels of E-cadherin were increased in a curcumin concentration-dependent manner.	Curcumin	56-64	cadherin 1	Homo sapiens	25-35
32899726-0	2020	Chlorogenic Acid Potentiates the Anti-Inflammatory Activity of Curcumin in LPS-Stimulated THP-1 Cells.	Curcumin	63-71	GLI family zinc finger 2	Homo sapiens	90-95
32899726-4	2020	In this study, the anti-inflammatory potential of curcumin in combination with chlorogenic acid (CGA), was investigated using human THP-1 macrophages stimulated with lipopolysaccharide (LPS).	Curcumin	50-58	GLI family zinc finger 2	Homo sapiens	132-137
32899726-5	2020	Curcumin alone suppressed TNF-alpha production in a dose-dependent manner with a decrease in cell viability at higher doses.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	26-35
32899726-6	2020	Although treatment with CGA alone had no effect on TNF-alpha production, it however enhanced cell viability and co-administration with curcumin at a 1:1 ratio caused a synergistic reduction in TNF-alpha production with no impact on cell viability.	Curcumin	135-143	tumor necrosis factor	Homo sapiens	193-202
32899726-9	2020	Curcumin and CGA together reduced the mRNA expression of pro-inflammatory cytokines [TNF-alpha (~88%) and IL-6 (~99%)], and COX-2 (~92%), possibly by suppression of NF-kappaB (~78%), IkappaB-beta-kinase (~60%) and TLR-4 receptor (~72%) at the mRNA level.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	85-94
32899726-9	2020	Curcumin and CGA together reduced the mRNA expression of pro-inflammatory cytokines [TNF-alpha (~88%) and IL-6 (~99%)], and COX-2 (~92%), possibly by suppression of NF-kappaB (~78%), IkappaB-beta-kinase (~60%) and TLR-4 receptor (~72%) at the mRNA level.	Curcumin	0-8	interleukin 6	Homo sapiens	106-110
32899726-9	2020	Curcumin and CGA together reduced the mRNA expression of pro-inflammatory cytokines [TNF-alpha (~88%) and IL-6 (~99%)], and COX-2 (~92%), possibly by suppression of NF-kappaB (~78%), IkappaB-beta-kinase (~60%) and TLR-4 receptor (~72%) at the mRNA level.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
32899726-9	2020	Curcumin and CGA together reduced the mRNA expression of pro-inflammatory cytokines [TNF-alpha (~88%) and IL-6 (~99%)], and COX-2 (~92%), possibly by suppression of NF-kappaB (~78%), IkappaB-beta-kinase (~60%) and TLR-4 receptor (~72%) at the mRNA level.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	165-174
32899726-10	2020	Overall, co-administration with CGA improved the inflammation-lowering effects of curcumin in THP-1 cells.	Curcumin	82-90	GLI family zinc finger 2	Homo sapiens	94-99
32074070-0	2020	Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	134-137
32074070-0	2020	Curcumin inhibits migration and invasion of non-small cell lung cancer cells through up-regulation of miR-206 and suppression of PI3K/AKT/mTOR signaling pathway.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	138-142
32074070-3	2020	In this study, we investigated the involvement of miR-206 in curcumin"s anti-invasion and anti-migration in NSCLC.	Curcumin	61-69	microRNA 206	Homo sapiens	50-57
32074070-8	2020	Curcumin significantly inhibited migration and invasion in A549 cells, accompanied by significantly elevated miR-206 expression.	Curcumin	0-8	microRNA 206	Homo sapiens	109-116
32074070-11	2020	Furthermore, miR-206 mimics improved the inhibitory effects of curcumin on cell migration, invasion and the phosphorylation level of mTOR and AKT in A549 cells.	Curcumin	63-71	microRNA 206	Homo sapiens	13-20
32074070-12	2020	On the contrary, MiR-206 inhibitors reversed the inhibitory effects of curcumin on cell migration, invasion and the phosphorylation level of mTOR and AKT.	Curcumin	71-79	microRNA 206	Homo sapiens	17-24
32074070-12	2020	On the contrary, MiR-206 inhibitors reversed the inhibitory effects of curcumin on cell migration, invasion and the phosphorylation level of mTOR and AKT.	Curcumin	71-79	mechanistic target of rapamycin kinase	Homo sapiens	141-145
32074070-12	2020	On the contrary, MiR-206 inhibitors reversed the inhibitory effects of curcumin on cell migration, invasion and the phosphorylation level of mTOR and AKT.	Curcumin	71-79	AKT serine/threonine kinase 1	Homo sapiens	150-153
32074070-13	2020	In conclusion, curcumin inhibited cell invasion and migration in NSCLC by elevating the expression of miR-206 which further suppressed the activation of the PI3K/AKT/mTOR pathway.	Curcumin	15-23	microRNA 206	Homo sapiens	102-109
32074070-13	2020	In conclusion, curcumin inhibited cell invasion and migration in NSCLC by elevating the expression of miR-206 which further suppressed the activation of the PI3K/AKT/mTOR pathway.	Curcumin	15-23	AKT serine/threonine kinase 1	Homo sapiens	162-165
32074070-13	2020	In conclusion, curcumin inhibited cell invasion and migration in NSCLC by elevating the expression of miR-206 which further suppressed the activation of the PI3K/AKT/mTOR pathway.	Curcumin	15-23	mechanistic target of rapamycin kinase	Homo sapiens	166-170
32464442-10	2020	Our findings indicated that curcumin showed antioxidant properties through the Nrf2 antioxidant signaling pathway and alleviates arsenic-triggered toxicity in PC12 cells by regulating autophagy/apoptosis.	Curcumin	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	79-83
32464442-9	2020	Furthermore, pretreatment of curcumin with arsenic expressively alleviated arsenic-induced toxicity and cell death by reversing the expressions of proteins; mTOR, Akt, Nrf2, ERK1, Bcl-x, Xiap, ULK, LC3, p53, Bax, cytochrome c, caspase 9 and cleaved caspase 3.	Curcumin	29-37	AKT serine/threonine kinase 1	Rattus norvegicus	163-166
32464442-9	2020	Furthermore, pretreatment of curcumin with arsenic expressively alleviated arsenic-induced toxicity and cell death by reversing the expressions of proteins; mTOR, Akt, Nrf2, ERK1, Bcl-x, Xiap, ULK, LC3, p53, Bax, cytochrome c, caspase 9 and cleaved caspase 3.	Curcumin	29-37	NFE2 like bZIP transcription factor 2	Rattus norvegicus	168-172
32782494-0	2020	Curcumin affects ox-LDL-induced IL-6, TNF-alpha, MCP-1 secretion and cholesterol efflux in THP-1 cells by suppressing the TLR4/NF-kappaB/miR33a signaling pathway.	Curcumin	0-8	interleukin 6	Homo sapiens	32-36
32464442-9	2020	Furthermore, pretreatment of curcumin with arsenic expressively alleviated arsenic-induced toxicity and cell death by reversing the expressions of proteins; mTOR, Akt, Nrf2, ERK1, Bcl-x, Xiap, ULK, LC3, p53, Bax, cytochrome c, caspase 9 and cleaved caspase 3.	Curcumin	29-37	caspase 9	Rattus norvegicus	227-236
32782494-9	2020	However, pretreatment with curcumin increased the expression of ABCA1 and cholesterol efflux and suppressed secretion of TNF-alpha, MCP-1 and Il-6.	Curcumin	27-35	tumor necrosis factor	Homo sapiens	121-130
32782494-9	2020	However, pretreatment with curcumin increased the expression of ABCA1 and cholesterol efflux and suppressed secretion of TNF-alpha, MCP-1 and Il-6.	Curcumin	27-35	interleukin 6	Homo sapiens	142-146
32782494-11	2020	Curcumin promoted cholesterol efflux by suppressing the TLR4/NF-kappaB/miR33a signaling pathway, and reduced the formation of foam cells and the secretion of inflammatory factors.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	61-70
32808552-10	2020	The molecular modeling study depicted that PVP increased the stability of the ternary complex by forming the link between CUR and beta CD.	Curcumin	122-125	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	130-137
32782494-0	2020	Curcumin affects ox-LDL-induced IL-6, TNF-alpha, MCP-1 secretion and cholesterol efflux in THP-1 cells by suppressing the TLR4/NF-kappaB/miR33a signaling pathway.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	38-47
32782494-0	2020	Curcumin affects ox-LDL-induced IL-6, TNF-alpha, MCP-1 secretion and cholesterol efflux in THP-1 cells by suppressing the TLR4/NF-kappaB/miR33a signaling pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	127-136
32691972-5	2020	Immunohistochemical analysis and qPCR revealed that topically applied curcumin either before, after or in combination with acidic bile exposure significantly suppressed its induced NF-kappaB activation in regenerating epithelial cells, and overexpression of Rela, Bcl2, Egfr, Stat3, Wnt5a, Tnf, Il6, Ptgs2.	Curcumin	70-78	Wnt family member 5A	Homo sapiens	283-288
32725802-0	2020	Curcumin inhibits the growth of triple-negative breast cancer cells by silencing EZH2 and restoring DLC1 expression.	Curcumin	0-8	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	81-85
32725802-0	2020	Curcumin inhibits the growth of triple-negative breast cancer cells by silencing EZH2 and restoring DLC1 expression.	Curcumin	0-8	DLC1 Rho GTPase activating protein	Homo sapiens	100-104
32585605-3	2020	Curcumin and hesperidin are natural compounds with anti-inflammatory and antioxidant properties and have an inhibitory action on TLR4 receptors.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	129-133
32585605-7	2020	For assessing working memory and long-term potentiation, the double Y-maze test and Schaffer collateral-CA1 in vivo electrophysiological recording were performed, respectively Our results showed that curcumin and hesperidin decreased TNF-alpha, IL-10, and TLR4 protein expression and reversed memory dysfunction.	Curcumin	200-208	tumor necrosis factor	Rattus norvegicus	234-243
32585605-7	2020	For assessing working memory and long-term potentiation, the double Y-maze test and Schaffer collateral-CA1 in vivo electrophysiological recording were performed, respectively Our results showed that curcumin and hesperidin decreased TNF-alpha, IL-10, and TLR4 protein expression and reversed memory dysfunction.	Curcumin	200-208	toll-like receptor 4	Rattus norvegicus	256-260
32585605-9	2020	In addition, curcumin, but not hesperidin, decreased interleukin-1beta (IL-1beta) and MDA levels.	Curcumin	13-21	interleukin 1 beta	Rattus norvegicus	53-70
32585605-9	2020	In addition, curcumin, but not hesperidin, decreased interleukin-1beta (IL-1beta) and MDA levels.	Curcumin	13-21	interleukin 1 alpha	Rattus norvegicus	72-80
32585605-10	2020	These findings imply that curcumin and hesperidin induced significant protective effects on febrile seizures, possibly via their anti-inflammatory and antioxidant properties and downregulation of TLR4.	Curcumin	26-34	toll-like receptor 4	Rattus norvegicus	196-200
32691972-2	2020	We recently demonstrated in vitro that curcumin can prevent oncogenic profile of bile in human hypopharyngeal cells, by inhibiting NF-kappaB.	Curcumin	39-47	nuclear factor kappa B subunit 1	Homo sapiens	131-140
32691972-3	2020	We hypothesize that topically applied curcumin to the hypopharynx can similarly block early oncogenic molecular events of bile, by inhibiting NF-kappaB and consequently altering the expression of genes with oncogenic function.	Curcumin	38-46	nuclear factor kappa B subunit 1	Homo sapiens	142-151
32691972-5	2020	Immunohistochemical analysis and qPCR revealed that topically applied curcumin either before, after or in combination with acidic bile exposure significantly suppressed its induced NF-kappaB activation in regenerating epithelial cells, and overexpression of Rela, Bcl2, Egfr, Stat3, Wnt5a, Tnf, Il6, Ptgs2.	Curcumin	70-78	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	181-190
32691972-5	2020	Immunohistochemical analysis and qPCR revealed that topically applied curcumin either before, after or in combination with acidic bile exposure significantly suppressed its induced NF-kappaB activation in regenerating epithelial cells, and overexpression of Rela, Bcl2, Egfr, Stat3, Wnt5a, Tnf, Il6, Ptgs2.	Curcumin	70-78	BCL2 apoptosis regulator	Homo sapiens	264-268
32691972-5	2020	Immunohistochemical analysis and qPCR revealed that topically applied curcumin either before, after or in combination with acidic bile exposure significantly suppressed its induced NF-kappaB activation in regenerating epithelial cells, and overexpression of Rela, Bcl2, Egfr, Stat3, Wnt5a, Tnf, Il6, Ptgs2.	Curcumin	70-78	epidermal growth factor receptor	Homo sapiens	270-274
32691972-5	2020	Immunohistochemical analysis and qPCR revealed that topically applied curcumin either before, after or in combination with acidic bile exposure significantly suppressed its induced NF-kappaB activation in regenerating epithelial cells, and overexpression of Rela, Bcl2, Egfr, Stat3, Wnt5a, Tnf, Il6, Ptgs2.	Curcumin	70-78	signal transducer and activator of transcription 3	Homo sapiens	276-281
32725802-7	2020	Furthermore, we found that curcumin restored the expression of DLC1 by inhibiting EZH2; it also inhibited the migration, invasion and proliferation of MDA-MB-231 cells, promoted their apoptosis and blocked the cell cycle.	Curcumin	27-35	DLC1 Rho GTPase activating protein	Homo sapiens	63-67
32725802-7	2020	Furthermore, we found that curcumin restored the expression of DLC1 by inhibiting EZH2; it also inhibited the migration, invasion and proliferation of MDA-MB-231 cells, promoted their apoptosis and blocked the cell cycle.	Curcumin	27-35	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	82-86
32725802-8	2020	Finally, xenograft tumour models were used to demonstrate that curcumin restored DLC1 expression by inhibiting EZH2 and also inhibited the growth and promoted the apoptosis of TNBC cells.	Curcumin	63-71	DLC1 Rho GTPase activating protein	Homo sapiens	81-85
32725802-8	2020	Finally, xenograft tumour models were used to demonstrate that curcumin restored DLC1 expression by inhibiting EZH2 and also inhibited the growth and promoted the apoptosis of TNBC cells.	Curcumin	63-71	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	111-115
32725802-9	2020	In conclusion, our results suggest that curcumin can inhibit the migration, invasion and proliferation, promote the apoptosis, block the cycle of TNBC cells and restore the expression of DLC1 by inhibiting the expression of EZH2.	Curcumin	40-48	DLC1 Rho GTPase activating protein	Homo sapiens	187-191
32725802-9	2020	In conclusion, our results suggest that curcumin can inhibit the migration, invasion and proliferation, promote the apoptosis, block the cycle of TNBC cells and restore the expression of DLC1 by inhibiting the expression of EZH2.	Curcumin	40-48	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	224-228
32691972-5	2020	Immunohistochemical analysis and qPCR revealed that topically applied curcumin either before, after or in combination with acidic bile exposure significantly suppressed its induced NF-kappaB activation in regenerating epithelial cells, and overexpression of Rela, Bcl2, Egfr, Stat3, Wnt5a, Tnf, Il6, Ptgs2.	Curcumin	70-78	tumor necrosis factor	Homo sapiens	290-293
32691972-5	2020	Immunohistochemical analysis and qPCR revealed that topically applied curcumin either before, after or in combination with acidic bile exposure significantly suppressed its induced NF-kappaB activation in regenerating epithelial cells, and overexpression of Rela, Bcl2, Egfr, Stat3, Wnt5a, Tnf, Il6, Ptgs2.	Curcumin	70-78	interleukin 6	Homo sapiens	295-298
32691972-5	2020	Immunohistochemical analysis and qPCR revealed that topically applied curcumin either before, after or in combination with acidic bile exposure significantly suppressed its induced NF-kappaB activation in regenerating epithelial cells, and overexpression of Rela, Bcl2, Egfr, Stat3, Wnt5a, Tnf, Il6, Ptgs2.	Curcumin	70-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	300-305
32691972-6	2020	Akt1 was particularly inhibited by curcumin when applied simultaneously with bile.	Curcumin	35-43	AKT serine/threonine kinase 1	Homo sapiens	0-4
32691972-7	2020	We provide novel evidence into the preventive and therapeutic properties of topically applied curcumin in acidic bile-induced early oncogenic molecular events in hypopharyngeal mucosa, by inhibiting NF-kappaB, and shaping future translational development of effective targeted therapies using topical non-pharmacologic inhibitors of NF-kappaB.	Curcumin	94-102	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	199-208
32691972-7	2020	We provide novel evidence into the preventive and therapeutic properties of topically applied curcumin in acidic bile-induced early oncogenic molecular events in hypopharyngeal mucosa, by inhibiting NF-kappaB, and shaping future translational development of effective targeted therapies using topical non-pharmacologic inhibitors of NF-kappaB.	Curcumin	94-102	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	333-342
32436614-0	2020	Curcumin alleviates OGD/R-induced PC12 cell damage via repressing CCL3 and inactivating TLR4/MyD88/MAPK/NF-kappaB to suppress inflammation and apoptosis.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	88-92
32436614-11	2020	Moreover, high expression levels of TLR4, MyD88, p-NF-kappaB P65, p-P38 MAPK and p-IkappaBalpha in OGD/R model were inhibited by curcumin.	Curcumin	129-137	toll-like receptor 4	Rattus norvegicus	36-40
32735850-0	2020	The neuroprotective effect of curcumin against Cd-induced neurotoxicity and hippocampal neurogenesis promotion through CREB-BDNF signaling pathway.	Curcumin	30-38	cAMP responsive element binding protein 1	Mus musculus	119-123
32830149-0	2020	Curcumin targets vascular endothelial growth factor via activating the PI3K/Akt signaling pathway and improves brain hypoxic-ischemic injury in neonatal rats.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	76-79
32526690-7	2020	Curcumin inhibits levels of reactive oxygen species (ROS) and oxidative stress in hepatocytes by activating PPAR-alpha, and regulates upstream signaling pathways of autophagy AMPK and PI3K/AKT/mTOR, leading to an increase of the autophagic flow in hepatocytes.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	189-192
32526690-7	2020	Curcumin inhibits levels of reactive oxygen species (ROS) and oxidative stress in hepatocytes by activating PPAR-alpha, and regulates upstream signaling pathways of autophagy AMPK and PI3K/AKT/mTOR, leading to an increase of the autophagic flow in hepatocytes.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	193-197
32830149-6	2020	In addition, IGF-1 treatment rescued the curcumin-induced down-regulated expression of p- PI3K, p-Akt, and VEGF, and VEGF overexpression counteracted the inhibitory effect of curcumin on brain HI damage.	Curcumin	41-49	AKT serine/threonine kinase 1	Rattus norvegicus	98-101
32830149-7	2020	Overall, pretreatment with curcumin protected against brain HI damage by targeting VEGF via the PI3K/Akt signaling pathway in neonatal rats.	Curcumin	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	101-104
32767918-0	2021	Comparative Inhibitory Efficacy on the iNOS/NO System of Curcumin- and Tetrahydrocurcumin-Self-Microemulsifying Liquid Formulation in Chronic Gastric Ulcer Model.	Curcumin	57-65	nitric oxide synthase 2	Rattus norvegicus	39-43
32811563-13	2020	Moreover, curcumin treatment reduced the concentrations of TNF-alpha, IL-1beta and MDA, while increased the GSH contents as well as the SOD and GSH-Px activities in the cerebral homogenates, in comparison to ACR control group.	Curcumin	10-18	tumor necrosis factor	Rattus norvegicus	59-68
32811563-13	2020	Moreover, curcumin treatment reduced the concentrations of TNF-alpha, IL-1beta and MDA, while increased the GSH contents as well as the SOD and GSH-Px activities in the cerebral homogenates, in comparison to ACR control group.	Curcumin	10-18	interleukin 1 alpha	Rattus norvegicus	70-78
32445778-10	2020	In addition, we administered curcumin to nude mice and found that curcumin decreased the tumor volume, caused necrosis of tumor tissue, and significantly enhanced the PTEN and p53 expression in vivo.	Curcumin	29-37	phosphatase and tensin homolog	Mus musculus	167-171
32445778-10	2020	In addition, we administered curcumin to nude mice and found that curcumin decreased the tumor volume, caused necrosis of tumor tissue, and significantly enhanced the PTEN and p53 expression in vivo.	Curcumin	66-74	phosphatase and tensin homolog	Mus musculus	167-171
32445778-11	2020	CONCLUSIONS: These results indicated that curcumin inhibited proliferation by decreasing the p-AKT/p-mTOR pathway, and promoted apoptosis by increasing the PTEN and p53 expression.	Curcumin	42-50	thymoma viral proto-oncogene 1	Mus musculus	95-98
32445778-11	2020	CONCLUSIONS: These results indicated that curcumin inhibited proliferation by decreasing the p-AKT/p-mTOR pathway, and promoted apoptosis by increasing the PTEN and p53 expression.	Curcumin	42-50	phosphatase and tensin homolog	Mus musculus	156-160
32507349-6	2020	METHOD: Three phytochemicals; Sulforaphane, Curcumin, and Resveratrol were selected, and studies were reviewed to clarify their intracellular signaling mechanism in NLRP3 inflammasome activity.	Curcumin	44-52	NLR family pyrin domain containing 3	Homo sapiens	165-170
32770697-0	2020	Curcumin and Baicalin ameliorate ethanol-induced liver oxidative damage via the Nrf2/HO-1 pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	80-84
32770697-8	2020	Combination treatment of Curcumin and Baicalin significantly reversed the ethanol-induced liver oxidative damage and further activate the Nrf2/HO-1 pathway, which was more effective than each drug alone.	Curcumin	25-33	NFE2 like bZIP transcription factor 2	Rattus norvegicus	138-142
32445778-0	2020	Curcumin suppress glioblastoma cell proliferation by p-AKT/mTOR pathway and increased the PTEN expression.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	55-58
32445778-0	2020	Curcumin suppress glioblastoma cell proliferation by p-AKT/mTOR pathway and increased the PTEN expression.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	59-63
32445778-8	2020	We detected that curcumin decreased p-AKT and p-mTOR protein expression, and promoted apoptosis of U251 and U87 GB cells.	Curcumin	17-25	AKT serine/threonine kinase 1	Homo sapiens	38-41
32445778-8	2020	We detected that curcumin decreased p-AKT and p-mTOR protein expression, and promoted apoptosis of U251 and U87 GB cells.	Curcumin	17-25	mechanistic target of rapamycin kinase	Homo sapiens	48-52
32445778-9	2020	Further, we found that curcumin promoted the PTEN and p53 expression, as the tumor suppressor genes.	Curcumin	23-31	tumor protein p53	Homo sapiens	54-57
32922301-9	2020	TNF alpha levels could also be reduced by statins, aspirin, and curcumin.	Curcumin	64-72	tumor necrosis factor	Homo sapiens	0-9
32922301-10	2020	Chloride transport could be facilitated by CFTR activators, including curcumin and phosphodiesterase-5 inhibitors.	Curcumin	70-78	CF transmembrane conductance regulator	Homo sapiens	43-47
32785161-0	2020	Design of Curcumin and Flavonoid Derivatives with Acetylcholinesterase and Beta-Secretase Inhibitory Activities Using in Silico Approaches.	Curcumin	10-18	acetylcholinesterase (Cartwright blood group)	Homo sapiens	50-70
32785161-5	2020	A combinatorial library containing more than 3 million structures of curcumin and flavonoid derivatives was generated and screened for drug-likeness and enzymatic inhibitory bioactivities against AChE and BACE-1 through the validated in silico models.	Curcumin	69-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	196-200
32785161-5	2020	A combinatorial library containing more than 3 million structures of curcumin and flavonoid derivatives was generated and screened for drug-likeness and enzymatic inhibitory bioactivities against AChE and BACE-1 through the validated in silico models.	Curcumin	69-77	beta-secretase 1	Homo sapiens	205-211
32785161-6	2020	A total of 47 substances (two curcumins and 45 flavonoids), with remarkable predicted pIC50 values against AChE and BACE-1 ranging from 4.24-5.11 (AChE) and 4.52-10.27 (BACE-1), were designed.	Curcumin	30-39	beta-secretase 1	Homo sapiens	116-122
32831861-0	2020	Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway.	Curcumin	0-8	C-reactive protein	Rattus norvegicus	40-43
32831861-3	2020	Here, the effect of curcumin on aldosterone-induced C-reactive protein generation in vascular smooth muscle and the molecular mechanisms involved were explored.	Curcumin	20-28	C-reactive protein	Rattus norvegicus	52-70
32831861-6	2020	We found that curcumin inhibited aldosterone-induced C-reactive protein generation in vascular smooth muscle cells by interfering with the reactive oxygen species-ERK1/2 signal pathway.	Curcumin	14-22	C-reactive protein	Rattus norvegicus	53-71
32767918-1	2021	BACKGROUND: Curcumin was found to accelerate gastric ulcer healing by a main mechanism through suppression of iNOS mediated inflammation.	Curcumin	12-20	nitric oxide synthase 2	Rattus norvegicus	110-114
32767918-5	2021	OBJECTIVE: This study aimed to evaluate and compare antiulcer efficacy of curcumin- and THC-SMEDDS through inhibition of the iNOS/NO system in rat model.	Curcumin	74-82	nitric oxide synthase 2	Rattus norvegicus	125-129
32615888-0	2020	Curcumin attenuates inflammation and cell apoptosis through regulating NF-kappaB and JAK2/STAT3 signaling pathway against acute kidney injury.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-80
32502496-0	2020	The pivotal role of SUMO-1-JNK-Tau axis in an in vitro model of oxidative stress counteracted by the protective effect of curcumin.	Curcumin	122-130	mitogen-activated protein kinase 8	Homo sapiens	27-30
32502496-5	2020	Curcumin, a natural compound with anti-oxidant and anti-inflammatory effects, demonstrated to tackle oxidative stress re-equilibrating SUMO-1, JNK and Tau functions.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	143-146
32502496-8	2020	These results highlight the SUMO-1-JNK-Tau axis key role in oxidative stress and the protective effect of curcumin against this pathological event, focusing on the importance of SUMO/deSUMOylation balance to regulate essential cellular processes.	Curcumin	106-114	mitogen-activated protein kinase 8	Homo sapiens	35-38
32757174-11	2021	While KCNQ1OT1 overexpression removed the effect of curcumin on HCT8/DDP cells via miR-497/ Bcl-2 axis.	Curcumin	52-60	BCL2 apoptosis regulator	Homo sapiens	92-97
32759757-0	2020	The Curcumin Analogue, EF-24, Triggers p38 MAPK-Mediated Apoptotic Cell Death via Inducing PP2A-Modulated ERK Deactivation in Human Acute Myeloid Leukemia Cells.	Curcumin	4-12	mitogen-activated protein kinase 1	Homo sapiens	106-109
31967866-0	2020	Reversal of P-Glycoprotein-Mediated Multidrug Resistance by Novel Curcumin Analogues in Paclitaxel-resistant Human Breast Cancer Cells.	Curcumin	66-74	ATP binding cassette subfamily B member 1	Homo sapiens	12-26
32968631-0	2020	Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K/Akt/mTOR-dependent manner.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	76-79
32968631-0	2020	Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K/Akt/mTOR-dependent manner.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	80-84
32615888-0	2020	Curcumin attenuates inflammation and cell apoptosis through regulating NF-kappaB and JAK2/STAT3 signaling pathway against acute kidney injury.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	90-95
32535538-5	2020	Curcumin could also suppress the expressions of NF-kappaB-p105 in BLM/IL-17A exposed mice.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	48-57
32615888-4	2020	Further assays showed that Curcumin partly attenuated the LPS-induced injury as the viability was enhanced, TNF-alpha and IL-6 expressions and cell apoptosis rates were reduced.	Curcumin	27-35	tumor necrosis factor	Mus musculus	108-117
32615888-4	2020	Further assays showed that Curcumin partly attenuated the LPS-induced injury as the viability was enhanced, TNF-alpha and IL-6 expressions and cell apoptosis rates were reduced.	Curcumin	27-35	interleukin 6	Mus musculus	122-126
32615888-5	2020	Western blot analysis indicated that Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3, p-65-NF-kappaB and cell apoptosis pathways were activated by LPS but suppressed by Curcumin.	Curcumin	200-208	signal transducer and activator of transcription 3	Mus musculus	58-115
32615888-6	2020	Mice SAKI model further indicated that the serum Cystatin C (Cys-C), creatinine (Cr) and blood urea nitrogen (BUN) were increased within 24 h of model construction while those indicators were decreased at 48 h. Pretreated with Curcumin, NF-kappaB inhibitor (PDTC) or JAK2 inhibitor (AG-490) could weaken the renal histological injury and the increased serum Cys-C, Cr and BUN, IL-6 and TNF-alpha induced by CLP.	Curcumin	227-235	cystatin C	Mus musculus	49-59
32615888-6	2020	Mice SAKI model further indicated that the serum Cystatin C (Cys-C), creatinine (Cr) and blood urea nitrogen (BUN) were increased within 24 h of model construction while those indicators were decreased at 48 h. Pretreated with Curcumin, NF-kappaB inhibitor (PDTC) or JAK2 inhibitor (AG-490) could weaken the renal histological injury and the increased serum Cys-C, Cr and BUN, IL-6 and TNF-alpha induced by CLP.	Curcumin	227-235	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	237-246
32615888-6	2020	Mice SAKI model further indicated that the serum Cystatin C (Cys-C), creatinine (Cr) and blood urea nitrogen (BUN) were increased within 24 h of model construction while those indicators were decreased at 48 h. Pretreated with Curcumin, NF-kappaB inhibitor (PDTC) or JAK2 inhibitor (AG-490) could weaken the renal histological injury and the increased serum Cys-C, Cr and BUN, IL-6 and TNF-alpha induced by CLP.	Curcumin	227-235	interleukin 6	Mus musculus	377-381
32615888-6	2020	Mice SAKI model further indicated that the serum Cystatin C (Cys-C), creatinine (Cr) and blood urea nitrogen (BUN) were increased within 24 h of model construction while those indicators were decreased at 48 h. Pretreated with Curcumin, NF-kappaB inhibitor (PDTC) or JAK2 inhibitor (AG-490) could weaken the renal histological injury and the increased serum Cys-C, Cr and BUN, IL-6 and TNF-alpha induced by CLP.	Curcumin	227-235	tumor necrosis factor	Mus musculus	386-395
32615888-7	2020	Moreover, PDTC, AG-490 and Curcumin all significantly reversed the previously increased expressions of p-JAK2/STAT3, p-p65 and proapoptotic proteins in the mice with AKI.	Curcumin	27-35	signal transducer and activator of transcription 3	Mus musculus	110-115
32615888-8	2020	The present study revealed that Curcumin attenuated SAKI through inhibiting NF-kappaB and JAK2/STAT3 signaling pathways, and proposed that Curcumin could be a potential therapeutic agent for treating SAKI.	Curcumin	32-40	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-85
32615888-8	2020	The present study revealed that Curcumin attenuated SAKI through inhibiting NF-kappaB and JAK2/STAT3 signaling pathways, and proposed that Curcumin could be a potential therapeutic agent for treating SAKI.	Curcumin	32-40	signal transducer and activator of transcription 3	Mus musculus	95-100
32615888-8	2020	The present study revealed that Curcumin attenuated SAKI through inhibiting NF-kappaB and JAK2/STAT3 signaling pathways, and proposed that Curcumin could be a potential therapeutic agent for treating SAKI.	Curcumin	139-147	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-85
32615888-8	2020	The present study revealed that Curcumin attenuated SAKI through inhibiting NF-kappaB and JAK2/STAT3 signaling pathways, and proposed that Curcumin could be a potential therapeutic agent for treating SAKI.	Curcumin	139-147	signal transducer and activator of transcription 3	Mus musculus	95-100
32535538-5	2020	Curcumin could also suppress the expressions of NF-kappaB-p105 in BLM/IL-17A exposed mice.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	58-62
32535538-6	2020	mRNA expressions showed reduced expressions of PDGFA, PDGFB, CTGF, IGF1, NFkappaB1, NFkappaB2, MMP-3, MMP-9, and MMP-14 on curcumin treatment.	Curcumin	123-131	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-82
32626956-0	2020	miR-192-5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c-Myc and inactivating the Wnt/beta-catenin signaling pathway.	Curcumin	52-60	microRNA 192	Homo sapiens	0-7
32626932-9	2020	Furthermore, cell exposure to curcumin resulted in an increase in the relative expression of the two key proapoptotic proteins, cytochrome c and cleaved caspase-3, as well as the antiapoptotic protein haem oxygenase-1.	Curcumin	30-38	cytochrome c, somatic	Homo sapiens	128-140
32626932-9	2020	Furthermore, cell exposure to curcumin resulted in an increase in the relative expression of the two key proapoptotic proteins, cytochrome c and cleaved caspase-3, as well as the antiapoptotic protein haem oxygenase-1.	Curcumin	30-38	caspase 3	Homo sapiens	153-162
32626932-11	2020	Similarly, the expression levels of the chloride channel bestrophin-1 and the calcium channel coding gene calcium voltage-gated channel auxiliary subunit gamma4 were increased following exposure to curcumin.	Curcumin	198-206	bestrophin 1	Homo sapiens	57-69
31972207-4	2020	RESULTS: Curcumin significantly decreased the levels of serum Scr, BUN, and Cyc c and reduced kidney injury in LPS-induced AKI mice.	Curcumin	9-17	scruffy	Mus musculus	62-65
31972207-8	2020	Additionally, curcumin reduced the LPS-induced increase in Bax, cleaved-caspase3/caspase 3, p-IkBalpha/IkBalpha, p-p65/p65, p-JNK/JNK, and p-c-JUN/c-JUN protein expression, and increased Bcl2 protein expression in NRK cells.	Curcumin	14-22	lymphocyte cytosolic protein 1	Mus musculus	113-118
31972207-8	2020	Additionally, curcumin reduced the LPS-induced increase in Bax, cleaved-caspase3/caspase 3, p-IkBalpha/IkBalpha, p-p65/p65, p-JNK/JNK, and p-c-JUN/c-JUN protein expression, and increased Bcl2 protein expression in NRK cells.	Curcumin	14-22	B cell leukemia/lymphoma 2	Mus musculus	187-191
32626956-9	2020	Curcumin treatment inhibited NSCLC cell proliferation, migration, invasion and viability in a dose-dependent manner, in addition to promoting a dose-dependent increase in the expression levels of miR-192-5p and a reduction in c-Myc expression levels.	Curcumin	0-8	microRNA 192	Homo sapiens	196-203
32554101-7	2020	Administration of curcumin or curcumol significantly diminished the level of hydroxyproline hydroxyproline and alpha-smooth muscle actin (alpha-SMA), also the collagen I (Col-I) and collagen III (Col-III) deposition were reduced in the HLF.	Curcumin	18-26	actin alpha 1, skeletal muscle	Homo sapiens	138-147
32554101-9	2020	Autophagy as the scavenger was crippled in TGF-beta1-fibroblast overproliferation HLF, conversely the increased autophagosomes have been spotted in cytoplasm under transmission electron microscope which is consistent with up-regulation of Beclin1 and ATG7 after treatment with curcumin or curcumol in this study.	Curcumin	277-285	transforming growth factor beta 1	Homo sapiens	43-52
32554101-5	2020	In this study, we have investigated the effects of curcumin and curcumol in the fibroblast overproliferation model human lung fibroblast (HLF) inducing by TGF-beta1.	Curcumin	51-59	transforming growth factor beta 1	Homo sapiens	155-164
32626956-10	2020	Notably, the genetic knockdown of miR-192-5p blocked the inhibitory effects of curcumin on NSCLC progression and instead promoted NSCLC progression, which was observed to be partially reversed by c-Myc silencing; thus, c-Myc was suggested to be a direct target gene of miR-192-5p as demonstrated by the TargetScanHuman database, dual-lucierase and RIP assay results.	Curcumin	79-87	microRNA 192	Homo sapiens	34-41
32626956-11	2020	In addition, the curcumin-induced decreased expression levels of beta-catenin, cyclin D1 and c-Myc were rescued following the genetic knockdown of miR-192-5p.	Curcumin	17-25	microRNA 192	Homo sapiens	147-154
32626956-12	2020	In conclusion, these findings suggested that the upregulation of miR-192-5p may underlie the inhibitory effects of curcumin on NSCLC cells through targeting c-Myc and inactivating the Wnt/beta-catenin signaling pathway.	Curcumin	115-123	microRNA 192	Homo sapiens	65-72
32430842-6	2020	CM-NP exerted significantly higher effects on GSC viability, apoptosis, cell cycle arrest, and the expression of Bax, a pro-apoptotic marker, compared with CM.	Curcumin	0-2	BCL2 associated X, apoptosis regulator	Homo sapiens	113-116
32189385-0	2020	Curcumin inhibits calcification of human aortic valve interstitial cells by interfering NF-kappaB, AKT, and ERK pathways.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	88-97
32141025-0	2020	Curcumin augments therapeutic efficacy of TRAIL-based immunotoxins in leukemia.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	42-47
32141025-4	2020	OBJECTIVE: To investigate the TRAIL-sensitizing effect of curcumin in leukemia.	Curcumin	58-66	TNF superfamily member 10	Homo sapiens	30-35
32141025-5	2020	METHODS: The mechanism underlying TRAIL sensitization by curcumin was studied by flow cytometric analysis of TRAIL receptors in leukemic cell lines and patient samples, and immunoblot detection of TRAIL-apoptosis signaling proteins.	Curcumin	57-65	TNF superfamily member 10	Homo sapiens	34-39
32141025-5	2020	METHODS: The mechanism underlying TRAIL sensitization by curcumin was studied by flow cytometric analysis of TRAIL receptors in leukemic cell lines and patient samples, and immunoblot detection of TRAIL-apoptosis signaling proteins.	Curcumin	57-65	TNF superfamily member 10	Homo sapiens	109-114
32141677-2	2020	Curcumin is considered to play a role in the regulation of T-lymphocytes function in the lymphoid tissue of the large intestine, apoptosis of the human papilloma and the activity of the 26S proteasome, and p53 level.	Curcumin	0-8	tumor protein p53	Homo sapiens	206-209
32189385-0	2020	Curcumin inhibits calcification of human aortic valve interstitial cells by interfering NF-kappaB, AKT, and ERK pathways.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	99-102
32141025-5	2020	METHODS: The mechanism underlying TRAIL sensitization by curcumin was studied by flow cytometric analysis of TRAIL receptors in leukemic cell lines and patient samples, and immunoblot detection of TRAIL-apoptosis signaling proteins.	Curcumin	57-65	TNF superfamily member 10	Homo sapiens	109-114
32141025-6	2020	RESULTS: Curcumin augments TRAIL-apoptotic signaling in leukemic cells by upregulating the expression of DR4 and DR5 along with suppression of cFLIP and anti-apoptotic proteins Mcl-1, Bcl-xl, and XIAP.	Curcumin	9-17	TNF superfamily member 10	Homo sapiens	27-32
32189385-0	2020	Curcumin inhibits calcification of human aortic valve interstitial cells by interfering NF-kappaB, AKT, and ERK pathways.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	108-111
32141025-6	2020	RESULTS: Curcumin augments TRAIL-apoptotic signaling in leukemic cells by upregulating the expression of DR4 and DR5 along with suppression of cFLIP and anti-apoptotic proteins Mcl-1, Bcl-xl, and XIAP.	Curcumin	9-17	BCL2 like 1	Homo sapiens	184-190
32141025-7	2020	Curcumin pre-treatment significantly (p < 0.01) enhanced the sensitivity of leukemic cell lines to TRAIL recombinant proteins.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	99-104
32893562-0	2020	[Study on mechanism of curcumin in treatment of acute pancreatitis based on regulation of PI3K-Akt signaling pathway by miR-198].	Curcumin	23-31	AKT serine/threonine kinase 1	Rattus norvegicus	95-98
32141025-8	2020	IL2-TRAIL peptide in the presence of curcumin induced potent apoptosis (p < 0.001) as compared to TRAIL and IL2-TRAIL protein in leukemic cell lines with IC50 < 0.1 muMu.	Curcumin	37-45	interleukin 2	Homo sapiens	0-3
32141025-8	2020	IL2-TRAIL peptide in the presence of curcumin induced potent apoptosis (p < 0.001) as compared to TRAIL and IL2-TRAIL protein in leukemic cell lines with IC50 < 0.1 muMu.	Curcumin	37-45	TNF superfamily member 10	Homo sapiens	4-9
32141025-10	2020	CONCLUSION: Overall, our results suggest that curcumin potentiates TRAIL-induced apoptosis through modulation of death receptors and anti-apoptotic proteins which significantly enhances the therapeutic efficacy.	Curcumin	46-54	TNF superfamily member 10	Homo sapiens	67-72
32812392-9	2020	Both curcumin analogs attenuated increases in TNF-alpha in hyperoxic animals.	Curcumin	5-13	tumor necrosis factor	Rattus norvegicus	46-55
33089282-0	2020	[Effect of curcumin on TGF-beta1 /Smad3 pathway in rat gingival fibroblast treated with cyclosporine A].	Curcumin	11-19	transforming growth factor, beta 1	Rattus norvegicus	23-32
33089282-0	2020	[Effect of curcumin on TGF-beta1 /Smad3 pathway in rat gingival fibroblast treated with cyclosporine A].	Curcumin	11-19	SMAD family member 3	Rattus norvegicus	34-39
32893562-5	2020	HE staining showed that curcumin could improve the pathological changes of pancreas and reduce the pathological score of pancreas, while ELISA results showed that curcumin could decrease the levels of amylase, lipase and Bax in peripheral serum and increase the concentration of Bcl-2.	Curcumin	163-171	BCL2, apoptosis regulator	Rattus norvegicus	279-284
32893562-6	2020	Western blot results showed that the expression levels of PI3 K and p-Akt in pancreatic tissue of model rats were up-regulated after the intervention of curcumin, and the apoptosis rate of pancreatic cells decreased in TUNEL staining.	Curcumin	153-161	AKT serine/threonine kinase 1	Rattus norvegicus	70-73
32893562-8	2020	In conclusion, curcumin has an ideal effect on acute pancreatitis, and its mechanism may be mediated by miR-198-PI3 K-Akt axis.	Curcumin	15-23	AKT serine/threonine kinase 1	Rattus norvegicus	118-121
32734850-0	2021	Inhibitory effects of curcumin on aldose reductase and cyclooxygenase-2 enzymes.	Curcumin	22-30	aldo-keto reductase family 1 member B	Homo sapiens	34-50
32734850-0	2021	Inhibitory effects of curcumin on aldose reductase and cyclooxygenase-2 enzymes.	Curcumin	22-30	prostaglandin-endoperoxide synthase 2	Homo sapiens	55-71
32613952-5	2020	Furthermore, curcumin regulation of the disorder of glycolipid metabolism and EMT was also based on the PI3K/AKT pathway.	Curcumin	13-21	thymoma viral proto-oncogene 1	Mus musculus	109-112
32718217-0	2020	Positive effect of curcumin on experimental peridontitis via suppression of IL-1-beta and IL-6 expression level.	Curcumin	19-27	interleukin 1 alpha	Rattus norvegicus	76-85
32718217-0	2020	Positive effect of curcumin on experimental peridontitis via suppression of IL-1-beta and IL-6 expression level.	Curcumin	19-27	interleukin 6	Rattus norvegicus	90-94
32718217-8	2020	When the periodontitis groups were compared, curcumin treatment resulted in lower IL-1beta (Group 2 median: 0.002, Group 1 median: 0.12) and IL-6 (Group 2 median: 0.031, Group 1 median: 0.078) and higher IL-17 (Group 2 median: 1.07, Group 1 median: 0.583) relative mRNA expression in Group 2 than in Group 1 (p < 0.001).	Curcumin	45-53	interleukin 1 alpha	Rattus norvegicus	82-90
32718217-8	2020	When the periodontitis groups were compared, curcumin treatment resulted in lower IL-1beta (Group 2 median: 0.002, Group 1 median: 0.12) and IL-6 (Group 2 median: 0.031, Group 1 median: 0.078) and higher IL-17 (Group 2 median: 1.07, Group 1 median: 0.583) relative mRNA expression in Group 2 than in Group 1 (p < 0.001).	Curcumin	45-53	interleukin 6	Rattus norvegicus	141-145
32718217-11	2020	These results indicate that curcumin might be a promising agent for the prevention and/or treatment of periodontal diseases due to its decreasing effect on IL-1beta and IL-6 mRNA expression.	Curcumin	28-36	interleukin 1 alpha	Rattus norvegicus	156-164
32718217-11	2020	These results indicate that curcumin might be a promising agent for the prevention and/or treatment of periodontal diseases due to its decreasing effect on IL-1beta and IL-6 mRNA expression.	Curcumin	28-36	interleukin 6	Rattus norvegicus	169-173
32717861-3	2020	CU binds to amyloid-beta (Abeta) oligomers and inhibits the formation of Abeta plaques.	Curcumin	0-2	amyloid beta precursor protein	Homo sapiens	12-24
32717861-3	2020	CU binds to amyloid-beta (Abeta) oligomers and inhibits the formation of Abeta plaques.	Curcumin	0-2	amyloid beta precursor protein	Homo sapiens	26-31
32717861-3	2020	CU binds to amyloid-beta (Abeta) oligomers and inhibits the formation of Abeta plaques.	Curcumin	0-2	amyloid beta precursor protein	Homo sapiens	73-78
32717861-4	2020	Here, we combine GAL core with CU fragments and design a combinatorial library of GAL-CU hybrids as dual-site binding AChE inhibitors.	Curcumin	31-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-122
32613952-6	2020	A docking study was performed and proved the strong affinity between curcumin and the proteins of STAT3, FASN, and AKT.	Curcumin	69-77	signal transducer and activator of transcription 3	Mus musculus	98-103
32613952-6	2020	A docking study was performed and proved the strong affinity between curcumin and the proteins of STAT3, FASN, and AKT.	Curcumin	69-77	fatty acid synthase	Mus musculus	105-109
32613952-6	2020	A docking study was performed and proved the strong affinity between curcumin and the proteins of STAT3, FASN, and AKT.	Curcumin	69-77	thymoma viral proto-oncogene 1	Mus musculus	115-118
32733195-0	2020	Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling.	Curcumin	23-31	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	93-99
32724322-8	2020	Meanwhile, the curcumin treatment can downregulate miR-21 expression, upregulate TIMP3 expression, and inhibit the TGF-beta1/smad3 signaling pathway.	Curcumin	15-23	transforming growth factor beta 1	Homo sapiens	115-124
32724322-11	2020	Interestingly, the effect of miR-21 inhibition on cell proliferation, apoptosis, and TGF-beta1/smad3 signaling pathway in HepG2 and HCCLM3 cells exposed to curcumin was attenuated by TIMP3 silencing.	Curcumin	156-164	transforming growth factor beta 1	Homo sapiens	85-94
32724322-12	2020	Conclusion: Taken together, the present study suggests that miR-21 is involved in the anticancer activities of curcumin through targeting TIMP3, and the mechanism possibly refers to the inhibition of TGF-beta1/smad3 signaling pathway.	Curcumin	111-119	transforming growth factor beta 1	Homo sapiens	200-209
32765077-0	2020	Curcumin Inhibits the Tumorigenesis of Breast Cancer by Blocking Tafazzin/Yes-Associated Protein Axis [Retraction].	Curcumin	0-8	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	65-73
32774710-0	2020	Downregulation of LINC01021 by curcumin analog Da0324 inhibits gastric cancer progression through activation of P53.	Curcumin	31-39	p53 upregulated regulator of p53 levels	Homo sapiens	18-27
32774710-0	2020	Downregulation of LINC01021 by curcumin analog Da0324 inhibits gastric cancer progression through activation of P53.	Curcumin	31-39	tumor protein p53	Homo sapiens	112-115
32657624-10	2021	Curcumin induces apoptosis in Pre B- ALL and T- ALL cells by decreased NF-kB levels, increased p53 levels, PARP-1 cleavage.	Curcumin	0-8	tumor protein p53	Homo sapiens	95-98
32657624-10	2021	Curcumin induces apoptosis in Pre B- ALL and T- ALL cells by decreased NF-kB levels, increased p53 levels, PARP-1 cleavage.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	107-113
31654258-9	2020	In conclusion, CUR and/or Se mitigated LPS/DCL-induced liver injury in rats by suppressing TLR4 signaling, inflammation, and oxidative stress and boosting HO-1 and other antioxidants.	Curcumin	15-18	toll-like receptor 4	Rattus norvegicus	91-95
32650607-1	2020	Activation of nuclear factor erythroid-2-related factor 2 (NRF2) has been proven to be an effective means to prevent the development of cancer, and natural curcumin stands out as a potent NRF2 activator and cancer chemopreventive agent.	Curcumin	156-164	NFE2 like bZIP transcription factor 2	Homo sapiens	188-192
32464055-0	2020	Solid lipid nanoparticles enhanced the neuroprotective role of curcumin against epilepsy through activation of Bcl-2 family and P38 MAPK pathway.	Curcumin	63-71	B cell leukemia/lymphoma 2	Mus musculus	111-116
31654258-8	2020	In addition, CUR and/or Se reduced serum C-reactive protein, liver pro-inflammatory cytokines, and the expression of TLR4, NF-kappaB, JNK, and p38, and upregulated heme oxygenase-1 (HO-1).	Curcumin	13-16	C-reactive protein	Rattus norvegicus	41-59
31654258-8	2020	In addition, CUR and/or Se reduced serum C-reactive protein, liver pro-inflammatory cytokines, and the expression of TLR4, NF-kappaB, JNK, and p38, and upregulated heme oxygenase-1 (HO-1).	Curcumin	13-16	toll-like receptor 4	Rattus norvegicus	117-121
32020664-9	2020	In addition, ADMA treatment resulted in similar results to those of TGF-beta1, and Cur significantly attenuated the effect of TGF-beta1, accompanied by increased VE-cadherin, DDAH1 and NRF-2 and decreased matrix metalloproteinase-9 (MMP-9) and extracellular regulated protein kinases 1/2 (ERK1/2) phosphorylation.	Curcumin	83-86	transforming growth factor beta 1	Homo sapiens	126-135
32030812-8	2020	Application of topical curcumin also increased the expression level of RelA as the main subunit of the nuclear factor-kappaB (NF-kappaB) signalling pathway.	Curcumin	23-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	126-135
32434144-9	2020	In addition, significant increases in levels of rat testicular ACP, ALP, HMG-CoA, (CAT), SOD and GSH were recorded for MSG + Curcumin group.	Curcumin	125-133	catalase	Rattus norvegicus	83-86
32020664-9	2020	In addition, ADMA treatment resulted in similar results to those of TGF-beta1, and Cur significantly attenuated the effect of TGF-beta1, accompanied by increased VE-cadherin, DDAH1 and NRF-2 and decreased matrix metalloproteinase-9 (MMP-9) and extracellular regulated protein kinases 1/2 (ERK1/2) phosphorylation.	Curcumin	83-86	cadherin 5	Homo sapiens	162-173
32020664-9	2020	In addition, ADMA treatment resulted in similar results to those of TGF-beta1, and Cur significantly attenuated the effect of TGF-beta1, accompanied by increased VE-cadherin, DDAH1 and NRF-2 and decreased matrix metalloproteinase-9 (MMP-9) and extracellular regulated protein kinases 1/2 (ERK1/2) phosphorylation.	Curcumin	83-86	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	175-180
32020664-9	2020	In addition, ADMA treatment resulted in similar results to those of TGF-beta1, and Cur significantly attenuated the effect of TGF-beta1, accompanied by increased VE-cadherin, DDAH1 and NRF-2 and decreased matrix metalloproteinase-9 (MMP-9) and extracellular regulated protein kinases 1/2 (ERK1/2) phosphorylation.	Curcumin	83-86	NFE2 like bZIP transcription factor 2	Homo sapiens	185-190
32020664-9	2020	In addition, ADMA treatment resulted in similar results to those of TGF-beta1, and Cur significantly attenuated the effect of TGF-beta1, accompanied by increased VE-cadherin, DDAH1 and NRF-2 and decreased matrix metalloproteinase-9 (MMP-9) and extracellular regulated protein kinases 1/2 (ERK1/2) phosphorylation.	Curcumin	83-86	mitogen-activated protein kinase 3	Homo sapiens	244-287
32020664-9	2020	In addition, ADMA treatment resulted in similar results to those of TGF-beta1, and Cur significantly attenuated the effect of TGF-beta1, accompanied by increased VE-cadherin, DDAH1 and NRF-2 and decreased matrix metalloproteinase-9 (MMP-9) and extracellular regulated protein kinases 1/2 (ERK1/2) phosphorylation.	Curcumin	83-86	mitogen-activated protein kinase 3	Homo sapiens	289-295
32020664-11	2020	These results demonstrated that Cur inhibits TGF-beta1-induced endothelial-to-mesenchymal transition (EndMT) by stimulating DDAH1 expression via the NRF-2 pathway, thus attenuating endothelial cell fibrosis.	Curcumin	32-35	transforming growth factor beta 1	Homo sapiens	45-54
32020664-11	2020	These results demonstrated that Cur inhibits TGF-beta1-induced endothelial-to-mesenchymal transition (EndMT) by stimulating DDAH1 expression via the NRF-2 pathway, thus attenuating endothelial cell fibrosis.	Curcumin	32-35	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	124-129
32020664-11	2020	These results demonstrated that Cur inhibits TGF-beta1-induced endothelial-to-mesenchymal transition (EndMT) by stimulating DDAH1 expression via the NRF-2 pathway, thus attenuating endothelial cell fibrosis.	Curcumin	32-35	NFE2 like bZIP transcription factor 2	Homo sapiens	149-154
32655024-4	2020	RESULTS: Nano-curcumin significantly decreased fasting plasma glucose (beta = -19.68 mg/dL, 95% CI: -33.48 to -5.88; P < .05) and serum insulin levels (beta = -1.70 muIU/mL, 95% CI: -2.96 to -0.44; P < .05) when compared with patients who received placebo.	Curcumin	14-22	insulin	Homo sapiens	136-143
32348814-0	2020	Curcumin inhibits zearalenone-induced apoptosis and oxidative stress in Leydig cells via modulation of the PTEN/Nrf2/Bip signaling pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116
32348814-0	2020	Curcumin inhibits zearalenone-induced apoptosis and oxidative stress in Leydig cells via modulation of the PTEN/Nrf2/Bip signaling pathway.	Curcumin	0-8	heat shock protein family A (Hsp70) member 5	Homo sapiens	117-120
32146706-0	2020	Chemopreventive effects of nanoparticle curcumin in a mouse model of Pten-deficient prostate cancer.	Curcumin	40-48	phosphatase and tensin homolog	Mus musculus	69-73
32361190-5	2020	The combination immunotherapy in the present of free form of curcumin or ovalbumin with encapsulated forms of the another substance (P.OVA-CUR 10 and P.CUR 5-OVA), showed the highest level of IFN-gamma:IL-4 compared to other target groups.	Curcumin	61-69	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	135-138
32361190-5	2020	The combination immunotherapy in the present of free form of curcumin or ovalbumin with encapsulated forms of the another substance (P.OVA-CUR 10 and P.CUR 5-OVA), showed the highest level of IFN-gamma:IL-4 compared to other target groups.	Curcumin	61-69	interferon gamma	Mus musculus	192-201
32774819-0	2020	Curcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K/AKT/Nrf2 signaling pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	97-100
32774819-0	2020	Curcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K/AKT/Nrf2 signaling pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
32774819-9	2020	The results of western blotting and RT-qPCR revealed that the protein and mRNA levels of ALP, COL1 and RUNX2 were increased by curcumin, while the PI3K/AKT/Nrf2 signaling pathway was activated.	Curcumin	127-135	RUNX family transcription factor 2	Homo sapiens	103-108
32774819-9	2020	The results of western blotting and RT-qPCR revealed that the protein and mRNA levels of ALP, COL1 and RUNX2 were increased by curcumin, while the PI3K/AKT/Nrf2 signaling pathway was activated.	Curcumin	127-135	AKT serine/threonine kinase 1	Homo sapiens	152-155
32774819-9	2020	The results of western blotting and RT-qPCR revealed that the protein and mRNA levels of ALP, COL1 and RUNX2 were increased by curcumin, while the PI3K/AKT/Nrf2 signaling pathway was activated.	Curcumin	127-135	NFE2 like bZIP transcription factor 2	Homo sapiens	156-160
32774819-11	2020	Conclusion: Curcumin could promote the osteogenesis of hPDLSCs, and the effect is related to the PI3K/AKT/Nrf2 signaling pathway.	Curcumin	12-20	AKT serine/threonine kinase 1	Homo sapiens	102-105
32202049-3	2020	The results showed that curcumin significantly promoted the cellular activity of AXN-treated RIN-m5F cells, decreased the ratio of apoptosis, downregulated the level of malondialdehyde, upregulated the levels of superoxide dismutase and reactive oxygen species, increased the expression of Bcl-2, cleaved caspase-3, and cleaved PARP1, and decreased the expression of Bax in AXN-treated cells.	Curcumin	24-32	BCL2, apoptosis regulator	Rattus norvegicus	290-295
32774819-11	2020	Conclusion: Curcumin could promote the osteogenesis of hPDLSCs, and the effect is related to the PI3K/AKT/Nrf2 signaling pathway.	Curcumin	12-20	NFE2 like bZIP transcription factor 2	Homo sapiens	106-110
33680047-0	2020	Pharmacological Evidences for Curcumin Neuroprotective Effects against Lead-Induced Neurodegeneration: Possible Role of Akt/GSK3 Signaling Pathway.	Curcumin	30-38	AKT serine/threonine kinase 1	Rattus norvegicus	120-123
33680047-3	2020	The current study evaluates the role of Akt/GSK3 signaling pathway in mediating the neuroprotective effects of curcumin against lead -induced neurodegeneration in rats.	Curcumin	111-119	AKT serine/threonine kinase 1	Rattus norvegicus	40-43
33680047-11	2020	Thus, Curcumin via mediation of Akt/GSK3 signaling pathway confers neuroprotection against lead-induced neurodegeneration in hippocampus.	Curcumin	6-14	AKT serine/threonine kinase 1	Rattus norvegicus	32-35
32802291-9	2020	CU+LLLT decreases Bax/Bcl2 ratio which is an indicator of apoptosis and it also rescued a decrease in LC3 and ATG10 expression in comparison with 6-OHDA group.	Curcumin	0-2	BCL2, apoptosis regulator	Rattus norvegicus	22-26
32721183-9	2020	Curcumin increased the numbers of apoptotic cells and upregulated cleaved caspase-3 expression, and these effects were attenuated by miR-28-5p inhibition.	Curcumin	0-8	caspase 3	Homo sapiens	74-83
32802291-10	2020	Conclusion: This study shows that the combination of 5 muM CU and LLLT has the best neuroprotective effect on PC12 cells against 6-OHDA by decreasing the BAX/BCL2 ratio.	Curcumin	59-61	BCL2, apoptosis regulator	Rattus norvegicus	158-162
32802291-0	2020	The Effect of Low-Level Laser Therapy and Curcumin on the Expression of LC3, ATG10 and BAX/BCL2 Ratio in PC12 Cells Induced by 6-Hydroxide Dopamine.	Curcumin	42-50	BCL2, apoptosis regulator	Rattus norvegicus	91-95
33583782-6	2020	Curcumin treatment showed reduced amount of fibrosis and significant reduction in level of liver biomarkers, reversal of antioxidant enzymes (SOD and GSH), MDA level, catalase activity and regain of electrolyte homeostasis.	Curcumin	0-8	catalase	Rattus norvegicus	167-175
32572733-9	2020	Curcumin was found to block mRNA expressions of non- SMAD genes EGFR, JNK-1, JAK1, JAK2, STAT-1, STAT-3, MAPK14, also of TGF-beta1 and SMAD genes like SMAD 2, SMAD 3.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	97-103
32572733-9	2020	Curcumin was found to block mRNA expressions of non- SMAD genes EGFR, JNK-1, JAK1, JAK2, STAT-1, STAT-3, MAPK14, also of TGF-beta1 and SMAD genes like SMAD 2, SMAD 3.	Curcumin	0-8	SMAD family member 2	Mus musculus	151-157
32377752-0	2020	Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor-stromal crosstalk under hypoxic conditions via the IL-6/ERK/NF-kappaB axis.	Curcumin	0-8	interleukin 6	Homo sapiens	135-139
32377752-0	2020	Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor-stromal crosstalk under hypoxic conditions via the IL-6/ERK/NF-kappaB axis.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	140-143
32377752-0	2020	Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor-stromal crosstalk under hypoxic conditions via the IL-6/ERK/NF-kappaB axis.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	144-153
32377752-15	2020	Curcumin also suppressed the secretion and expression of IL-6 in PSCs.	Curcumin	0-8	interleukin 6	Homo sapiens	57-61
32377752-16	2020	In addition, curcumin and IL-6-neutralizing antibody treatment suppressed PSC-CM-modulated pancreatic cancer invasion, EMT and the changes in the expression of E-cadherin, vimentin and matrix metallopeptidase-9.	Curcumin	13-21	cadherin 1	Homo sapiens	160-170
32377752-17	2020	Furthermore, the increase in the levels of p-ERK and p-NF-kappaB induced by PSC-CM could be counterbalanced by both curcumin and IL-6-neutralizing antibody treatment under hypoxic conditions.	Curcumin	116-124	mitogen-activated protein kinase 1	Homo sapiens	45-48
32377752-17	2020	Furthermore, the increase in the levels of p-ERK and p-NF-kappaB induced by PSC-CM could be counterbalanced by both curcumin and IL-6-neutralizing antibody treatment under hypoxic conditions.	Curcumin	116-124	nuclear factor kappa B subunit 1	Homo sapiens	55-64
32377752-18	2020	Taken together, these data indicate that curcumin plays an important role in suppressing tumor-stromal crosstalk and pancreatic cancer metastasis by inhibiting the IL-6/ERK/NF-kappaB axis.	Curcumin	41-49	interleukin 6	Homo sapiens	164-168
32377752-18	2020	Taken together, these data indicate that curcumin plays an important role in suppressing tumor-stromal crosstalk and pancreatic cancer metastasis by inhibiting the IL-6/ERK/NF-kappaB axis.	Curcumin	41-49	mitogen-activated protein kinase 1	Homo sapiens	169-172
32377752-18	2020	Taken together, these data indicate that curcumin plays an important role in suppressing tumor-stromal crosstalk and pancreatic cancer metastasis by inhibiting the IL-6/ERK/NF-kappaB axis.	Curcumin	41-49	nuclear factor kappa B subunit 1	Homo sapiens	173-182
32377752-19	2020	Blocking the IL-6/ERK/NF-kappaB axis by curcumin may be a promising therapeutic strategy for the treatment of pancreatic cancer.	Curcumin	40-48	interleukin 6	Homo sapiens	13-17
32377752-19	2020	Blocking the IL-6/ERK/NF-kappaB axis by curcumin may be a promising therapeutic strategy for the treatment of pancreatic cancer.	Curcumin	40-48	mitogen-activated protein kinase 1	Homo sapiens	18-21
32377752-19	2020	Blocking the IL-6/ERK/NF-kappaB axis by curcumin may be a promising therapeutic strategy for the treatment of pancreatic cancer.	Curcumin	40-48	nuclear factor kappa B subunit 1	Homo sapiens	22-31
32617134-8	2020	Further, curcumin-induced DNA demethylation of hGCCs was mediated by the damaged DNA repair-p53-p21/GADD45A-cyclin/CDK-Rb/E2F-DNMT1 axis.	Curcumin	9-17	tumor protein p53	Homo sapiens	92-95
32605658-0	2020	A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status.	Curcumin	16-24	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
32605658-0	2020	A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status.	Curcumin	16-24	tumor protein p53	Homo sapiens	122-125
32605658-4	2020	In this study we aimed at evaluating NRF2 and p53 in several cancer cell lines carrying different endogenous p53 status, using a novel curcumin compound since curcumin has been shown to target both NRF2 and p53 and have anti-tumor activity.	Curcumin	135-143	NFE2 like bZIP transcription factor 2	Homo sapiens	198-202
32605658-4	2020	In this study we aimed at evaluating NRF2 and p53 in several cancer cell lines carrying different endogenous p53 status, using a novel curcumin compound since curcumin has been shown to target both NRF2 and p53 and have anti-tumor activity.	Curcumin	159-167	NFE2 like bZIP transcription factor 2	Homo sapiens	37-41
32605658-4	2020	In this study we aimed at evaluating NRF2 and p53 in several cancer cell lines carrying different endogenous p53 status, using a novel curcumin compound since curcumin has been shown to target both NRF2 and p53 and have anti-tumor activity.	Curcumin	159-167	NFE2 like bZIP transcription factor 2	Homo sapiens	198-202
32067269-0	2020	Curcumin inhibits cell viability, migration, and invasion of thymic carcinoma cells via downregulation of microRNA-27a.	Curcumin	0-8	microRNA 27a	Homo sapiens	106-118
32067269-6	2020	After miR-27a mimic transfection, whether miR-27a is involved in CUR-modulated cell behaviors was measured.	Curcumin	65-68	microRNA 27a	Homo sapiens	42-49
32067269-10	2020	Meanwhile, miR-27a expression was positively regulated in thymic carcinoma tissues and downregulated by CUR in TC1889 cells.	Curcumin	104-107	microRNA 27a	Homo sapiens	11-18
32067269-11	2020	Overexpressed miR-27a reversed the CUR-induced reduction of growth, migration, and invasion in TC1889 cells.	Curcumin	35-38	microRNA 27a	Homo sapiens	14-21
32067269-12	2020	Furthermore, CUR blocked mTOR and Notch 1 pathways via downregulating miR-27a.	Curcumin	13-16	mechanistic target of rapamycin kinase	Homo sapiens	25-29
32067269-12	2020	Furthermore, CUR blocked mTOR and Notch 1 pathways via downregulating miR-27a.	Curcumin	13-16	microRNA 27a	Homo sapiens	70-77
32067269-13	2020	We demonstrated that CUR blocked mTOR and Notch 1 pathways via downregulating miR-27a, thereby suppressing cell growth, migration, and invasion of thymic carcinoma cells.	Curcumin	21-24	mechanistic target of rapamycin kinase	Homo sapiens	33-37
32067269-13	2020	We demonstrated that CUR blocked mTOR and Notch 1 pathways via downregulating miR-27a, thereby suppressing cell growth, migration, and invasion of thymic carcinoma cells.	Curcumin	21-24	microRNA 27a	Homo sapiens	78-85
32605658-6	2020	RESULTS: We found that the curcumin compound induced a certain degree of cell death in all tested cancer cell lines, independently of the p53 status.	Curcumin	27-35	tumor protein p53	Homo sapiens	138-141
32605658-7	2020	At molecular level, the curcumin compound induced NRF2 activation, mutp53 degradation and/or wtp53 activation.	Curcumin	24-32	NFE2 like bZIP transcription factor 2	Homo sapiens	50-54
32605658-8	2020	Pharmacologic or genetic NRF2 inhibition further increased the curcumin-induced cell death in both mutp53- and wtp53-carrying cancer cell lines while it did not increase cell death in p53 null cells, suggesting a cytoprotective role for NRF2 and a critical role for functional p53 to achieve an efficient cancer cell response to therapy.	Curcumin	63-71	NFE2 like bZIP transcription factor 2	Homo sapiens	25-29
32605658-8	2020	Pharmacologic or genetic NRF2 inhibition further increased the curcumin-induced cell death in both mutp53- and wtp53-carrying cancer cell lines while it did not increase cell death in p53 null cells, suggesting a cytoprotective role for NRF2 and a critical role for functional p53 to achieve an efficient cancer cell response to therapy.	Curcumin	63-71	tumor protein p53	Homo sapiens	102-105
32605658-8	2020	Pharmacologic or genetic NRF2 inhibition further increased the curcumin-induced cell death in both mutp53- and wtp53-carrying cancer cell lines while it did not increase cell death in p53 null cells, suggesting a cytoprotective role for NRF2 and a critical role for functional p53 to achieve an efficient cancer cell response to therapy.	Curcumin	63-71	NFE2 like bZIP transcription factor 2	Homo sapiens	237-241
32605658-8	2020	Pharmacologic or genetic NRF2 inhibition further increased the curcumin-induced cell death in both mutp53- and wtp53-carrying cancer cell lines while it did not increase cell death in p53 null cells, suggesting a cytoprotective role for NRF2 and a critical role for functional p53 to achieve an efficient cancer cell response to therapy.	Curcumin	63-71	tumor protein p53	Homo sapiens	113-116
32605658-9	2020	CONCLUSIONS: These findings underline the prosurvival role of curcumin-induced NRF2 expression in cancer cells even when cells underwent mutp53 downregulation and/or wtp53 activation.	Curcumin	62-70	NFE2 like bZIP transcription factor 2	Homo sapiens	79-83
32556081-0	2020	Curcumin against imiquimod-induced psoriasis of mice through IL-6/STAT3 signaling pathway.	Curcumin	0-8	interleukin 6	Mus musculus	61-65
32556081-0	2020	Curcumin against imiquimod-induced psoriasis of mice through IL-6/STAT3 signaling pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	66-71
32617134-8	2020	Further, curcumin-induced DNA demethylation of hGCCs was mediated by the damaged DNA repair-p53-p21/GADD45A-cyclin/CDK-Rb/E2F-DNMT1 axis.	Curcumin	9-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	96-99
32151947-12	2020	Genetic and pharmacological Notch pathway inhibition by DAPT and Notch-1 siRNA exhibited decreased curcumin mediated neuroprotection.	Curcumin	99-107	notch receptor 1	Homo sapiens	28-33
32151947-0	2020	Notch pathway up-regulation via curcumin mitigates bisphenol-A (BPA) induced alterations in hippocampal oligodendrogenesis.	Curcumin	32-40	notch receptor 1	Homo sapiens	0-5
32151947-12	2020	Genetic and pharmacological Notch pathway inhibition by DAPT and Notch-1 siRNA exhibited decreased curcumin mediated neuroprotection.	Curcumin	99-107	notch receptor 1	Homo sapiens	65-72
32151947-10	2020	In silico docking studies suggested Notch pathway genes (Notch-1, Hes-1 and Mib-1) as potential targets of BPA and curcumin.	Curcumin	115-123	notch receptor 1	Homo sapiens	36-41
32151947-14	2020	Altogether, results suggest that curcumin protected BPA induced de-myelination and behavioural deficits through Notch pathway activation.	Curcumin	33-41	notch receptor 1	Homo sapiens	112-117
32151947-10	2020	In silico docking studies suggested Notch pathway genes (Notch-1, Hes-1 and Mib-1) as potential targets of BPA and curcumin.	Curcumin	115-123	notch receptor 1	Homo sapiens	57-64
32529309-5	2020	RESULTS: Curcumin demonstrated potent reversible inhibition of cytochrome P450 (CYP)3A4-mediated N-demethylation of imatinib and bosutinib and CYP2C8-mediated metabolism of imatinib with inhibitory constants (ki,u) of <=1.5 mumol.	Curcumin	9-17	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	63-87
32151947-11	2020	Curcumin reversed BPA mediated myelination inhibition via increasing the Notch pathway gene expression.	Curcumin	0-8	notch receptor 1	Homo sapiens	73-78
32612986-0	2020	Curcumin Protects Osteoblasts From Oxidative Stress-Induced Dysfunction via GSK3beta-Nrf2 Signaling Pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
31635898-4	2020	and reagents (dexamethasone (DEX), clarithromycin (CAM) and curcumin (CUM)) on HIF-1alpha expression in cultured normal nasal epithelial cells (NECs) were also evaluated.	Curcumin	60-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
32529309-11	2020	Although curcumin possesses a strong In Vitro inhibitory activity towards CYP3A4 and CYP2C8 enzymes, its interactions with imatinib and bosutinib were unlikely to be of clinical importance due to curcumin"s poor bioavailability.	Curcumin	9-17	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	74-80
31635898-4	2020	and reagents (dexamethasone (DEX), clarithromycin (CAM) and curcumin (CUM)) on HIF-1alpha expression in cultured normal nasal epithelial cells (NECs) were also evaluated.	Curcumin	70-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
31635898-8	2020	Both CAM and CUM showed an additive effect with DEX in inhibiting HIF-1alpha expression (P &lt; 0.05).	Curcumin	13-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-76
32270402-5	2020	To overcome these limitations, in this study, curcumin was conjugated with human serum albumin (HSA) and its effects on breast cancer cell lines were also measured.	Curcumin	46-54	albumin	Homo sapiens	81-94
32113849-7	2020	Moreover, we found that curcumin was very effective in preventing mitochondrial HKI release and ROS enhancement induced by alpha-synuclein fibrillation products.	Curcumin	24-32	hexokinase 1	Rattus norvegicus	80-83
32633404-0	2020	Curcumin exerts protective effect on PC12 cells against lidocaine-induced cytotoxicity by suppressing the formation of NLRP3 inflammasome.	Curcumin	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	119-124
32633404-4	2020	RESULTS: Lidocaine inhibited the viability of PC12 cells, and it induced cell apoptosis, promoted ROS release and activated NLRP3 inflammasome in PC12 cells, but its effects were reversed by the treatment of curcumin.	Curcumin	208-216	NLR family, pyrin domain containing 3	Rattus norvegicus	124-129
32633404-5	2020	Moreover, NLRP3 over-expression also induced cytotoxicity in PC12 cells, which was also rescued by the treatment of curcumin.	Curcumin	116-124	NLR family, pyrin domain containing 3	Rattus norvegicus	10-15
32633404-6	2020	CONCLUSIONS: Our study indicates that curcumin exerts protective effect against lidocaine-induced cytotoxicity on PC12 cells by suppressing the activity of NLRP3 inflammasome, which provides new ideas on screening natural product for neurological damage therapy.	Curcumin	38-46	NLR family, pyrin domain containing 3	Rattus norvegicus	156-161
32270402-5	2020	To overcome these limitations, in this study, curcumin was conjugated with human serum albumin (HSA) and its effects on breast cancer cell lines were also measured.	Curcumin	46-54	albumin	Homo sapiens	96-99
32279988-7	2020	In addition, activation profiles of OECs by CCM stimulus were assessed and levels of transglutaminase-2 (TG2) and phosphatidylserine receptor (PSR) in OECs stimulated by CCM were further determined.	Curcumin	170-173	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Rattus norvegicus	114-141
32279988-7	2020	In addition, activation profiles of OECs by CCM stimulus were assessed and levels of transglutaminase-2 (TG2) and phosphatidylserine receptor (PSR) in OECs stimulated by CCM were further determined.	Curcumin	170-173	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Rattus norvegicus	143-146
32270402-10	2020	The zeta potential of HSA-curcumin NPs was -7 mV, while it was -37 mV for curcumin.	Curcumin	26-34	albumin	Homo sapiens	22-25
32279988-9	2020	In addition, the levels of TG2 and PSR in CCM-treated OECs were significantly elevated.	Curcumin	42-45	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Rattus norvegicus	35-38
32270402-11	2020	The MTT and apoptosis assay results indicated that the toxicity of HSA-curcumin NPs on the normal cell are less than curcumin; however, its anti-cancer effects on the cancer cells are much greater, compared to curcumin.	Curcumin	71-79	albumin	Homo sapiens	67-70
32270402-12	2020	CONCLUSION: HSA-curcumin NPs increase curcumin solubility in water as well as its stability in physiological and acidic conditions.	Curcumin	16-24	albumin	Homo sapiens	12-15
32270402-12	2020	CONCLUSION: HSA-curcumin NPs increase curcumin solubility in water as well as its stability in physiological and acidic conditions.	Curcumin	38-46	albumin	Homo sapiens	12-15
32325281-7	2020	Alteration of the extracellular milieu along with inhibited expression of genes (hif-1alpha, ldh-a, mct-1, mdr-1andstat-3) and proteins (HIF-1alpha and HCAR-1) are indicated to be involved in curcumin-induced reversal of chemoresistance in HepG2 cells.	Curcumin	192-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	137-147
32325281-7	2020	Alteration of the extracellular milieu along with inhibited expression of genes (hif-1alpha, ldh-a, mct-1, mdr-1andstat-3) and proteins (HIF-1alpha and HCAR-1) are indicated to be involved in curcumin-induced reversal of chemoresistance in HepG2 cells.	Curcumin	192-200	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91
32128952-6	2020	Moreover, expression levels of BAX, BCL-2, and CASP9 genes were assessed among AGS cells treated with curcumin, doxorubicin, and Dox-Cur.	Curcumin	102-110	BCL2 associated X, apoptosis regulator	Homo sapiens	31-34
32128952-6	2020	Moreover, expression levels of BAX, BCL-2, and CASP9 genes were assessed among AGS cells treated with curcumin, doxorubicin, and Dox-Cur.	Curcumin	102-110	BCL2 apoptosis regulator	Homo sapiens	36-41
32081769-0	2020	The role of miR-21/RECK in the inhibition of osteosarcoma by curcumin.	Curcumin	61-69	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	19-23
32215945-2	2020	The present work aimed to evaluate the regulatory immune effect of curcumin in hepatic cirrhosis induced by carbon tetrachloride (CCl4) injections in experimental rats" model.	Curcumin	67-75	C-C motif chemokine ligand 4	Rattus norvegicus	130-134
32472295-0	2020	Curcumin protects BV2 cells against lipopolysaccharide-induced injury via adjusting the miR-362-3p/TLR4 axis.	Curcumin	0-8	toll-like receptor 4	Mus musculus	99-103
32472295-4	2020	Meanwhile, curcumin decreased the level of cleaved caspase-3 and the release of TNF-alpha, IL-1beta, IL-6, but increased IL-10 release in LPS-treated BV2 cells.	Curcumin	11-19	tumor necrosis factor	Mus musculus	80-89
32472295-4	2020	Meanwhile, curcumin decreased the level of cleaved caspase-3 and the release of TNF-alpha, IL-1beta, IL-6, but increased IL-10 release in LPS-treated BV2 cells.	Curcumin	11-19	interleukin 6	Mus musculus	101-105
32472295-4	2020	Meanwhile, curcumin decreased the level of cleaved caspase-3 and the release of TNF-alpha, IL-1beta, IL-6, but increased IL-10 release in LPS-treated BV2 cells.	Curcumin	11-19	interleukin 10	Mus musculus	121-126
32472295-8	2020	Moreover, miR-362-3p deletion attenuated the cytoprotective effects of curcumin by regulating TLR4 expression in LPS-induced BV2 cells.	Curcumin	71-79	toll-like receptor 4	Mus musculus	94-98
32081769-6	2020	However, the role of miR-21 and its target gene, reversion-inducing cysteine-rich protein with kazal motifs (RECK), in the anticancer activity of curcumin against osteosarcoma remains unclear.	Curcumin	146-154	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	109-113
32472295-9	2020	Furthermore, curcumin suppressed p-p65 expression via regulating miR-362-3p/TLR4 axis.	Curcumin	13-21	toll-like receptor 4	Mus musculus	76-80
32472295-10	2020	We discovered that curcumin exhibited protective effects against LPS-triggered cell injury via modulating miR-362-3p/TLR4 axis through NF-kappaB pathway.	Curcumin	19-27	toll-like receptor 4	Mus musculus	117-121
32081769-11	2020	We hereby show that curcumin upregulated the expression of RECK via miR-21, thereby subsequently regulating Wnt/beta-catenin signaling leading to the inhibition of osteosarcoma.	Curcumin	20-28	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	59-63
32405958-7	2020	Furthermore, curcumin reduced angiotensin-I-converting enzyme and arginase activities before and after treatment with cyclophosphamide.	Curcumin	13-21	angiotensin I converting enzyme	Rattus norvegicus	30-61
32563955-0	2020	Lower concentrations of curcumin inhibit Her2-Akt pathway components in human breast cancer cells, and other dietary botanicals potentiate this and lapatinib inhibition.	Curcumin	24-32	erb-b2 receptor tyrosine kinase 2	Homo sapiens	41-45
32391111-0	2020	Curcumin inhibits epithelial-mesenchymal transition in oral cancer cells via c-Met blockade.	Curcumin	0-8	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	77-82
32391111-8	2020	Notably, curcumin inhibited HGF-induced EMT and cell motility in HSC-4 and Ca9-22 cells via c-Met blockade.	Curcumin	9-17	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	92-97
32563955-0	2020	Lower concentrations of curcumin inhibit Her2-Akt pathway components in human breast cancer cells, and other dietary botanicals potentiate this and lapatinib inhibition.	Curcumin	24-32	AKT serine/threonine kinase 1	Homo sapiens	46-49
32391111-10	2020	Furthermore, curcumin was able to effectively inhibit the HGF-induced increase in the levels of vimentin by downregulating the expression of phosphorylated c-Met, an ERK.	Curcumin	13-21	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	156-161
32563955-3	2020	Here we test the hypothesis that attainable in vivo levels of dietary curcumin can reduce Her2 signaling.	Curcumin	70-78	erb-b2 receptor tyrosine kinase 2	Homo sapiens	90-94
32391111-10	2020	Furthermore, curcumin was able to effectively inhibit the HGF-induced increase in the levels of vimentin by downregulating the expression of phosphorylated c-Met, an ERK.	Curcumin	13-21	mitogen-activated protein kinase 1	Homo sapiens	166-169
32391111-11	2020	In conclusion, the results of the present study demonstrated that curcumin was able to reverse HGF-induced EMT, possibly by inhibiting c-Met expression in oral cancer cells, providing a strong basis for the development of novel approaches for the treatment of oral cancer.	Curcumin	66-74	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	135-140
32563955-4	2020	Consistent with previous studies, higher dose curcumin (18 mumol/L) inhibits Her2-Akt pathway signaling (pHer2, total Her2 and pAkt levels) and cell growth using AU565 human breast cancer cells.	Curcumin	46-54	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-81
32563955-4	2020	Consistent with previous studies, higher dose curcumin (18 mumol/L) inhibits Her2-Akt pathway signaling (pHer2, total Her2 and pAkt levels) and cell growth using AU565 human breast cancer cells.	Curcumin	46-54	AKT serine/threonine kinase 1	Homo sapiens	82-85
32563955-4	2020	Consistent with previous studies, higher dose curcumin (18 mumol/L) inhibits Her2-Akt pathway signaling (pHer2, total Her2 and pAkt levels) and cell growth using AU565 human breast cancer cells.	Curcumin	46-54	erb-b2 receptor tyrosine kinase 2	Homo sapiens	106-110
32563955-6	2020	At 4 mumol/L, curcumin reduced Her2 signaling, and even more when combined with quercetin or OptiBerry.	Curcumin	14-22	erb-b2 receptor tyrosine kinase 2	Homo sapiens	31-35
32563955-8	2020	We also found that 1.5 mumol/L curcumin strongly potentiated lapatinib inhibition of Her2-Akt pathway signaling, and more so for pAkt, when combined with quercetin plus OptiBerry (CQO).	Curcumin	31-39	erb-b2 receptor tyrosine kinase 2	Homo sapiens	85-89
32563955-8	2020	We also found that 1.5 mumol/L curcumin strongly potentiated lapatinib inhibition of Her2-Akt pathway signaling, and more so for pAkt, when combined with quercetin plus OptiBerry (CQO).	Curcumin	31-39	AKT serine/threonine kinase 1	Homo sapiens	90-93
32563955-10	2020	These studies demonstrate that a physiological attainable level of curcumin (1.5 mumol/L) can reduce some components of the critical Her2-Akt pathway; that even more complete inhibition can be achieved by combination with other dietary botanicals; and that curcumin and other botanicals can potentiate the action of the Her2-cancer metastatic drug lapatinib, in turn suggesting the potential anti-cancer clinical use of these botanicals.	Curcumin	67-75	erb-b2 receptor tyrosine kinase 2	Homo sapiens	133-137
32563955-10	2020	These studies demonstrate that a physiological attainable level of curcumin (1.5 mumol/L) can reduce some components of the critical Her2-Akt pathway; that even more complete inhibition can be achieved by combination with other dietary botanicals; and that curcumin and other botanicals can potentiate the action of the Her2-cancer metastatic drug lapatinib, in turn suggesting the potential anti-cancer clinical use of these botanicals.	Curcumin	67-75	AKT serine/threonine kinase 1	Homo sapiens	138-141
32563955-10	2020	These studies demonstrate that a physiological attainable level of curcumin (1.5 mumol/L) can reduce some components of the critical Her2-Akt pathway; that even more complete inhibition can be achieved by combination with other dietary botanicals; and that curcumin and other botanicals can potentiate the action of the Her2-cancer metastatic drug lapatinib, in turn suggesting the potential anti-cancer clinical use of these botanicals.	Curcumin	67-75	erb-b2 receptor tyrosine kinase 2	Homo sapiens	320-324
32278045-13	2020	Finally another suggested mechanism is suppression of MAOA/mTORC1/hypoxia-inducible factor 1alpha signaling pathway by curcumin.	Curcumin	119-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	66-97
32278045-5	2020	Curcumin may exert its anticancer function, at least in part, by suppressing mTOR-mediated signaling pathway in tumor cells.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	77-81
32278045-7	2020	According to literature, curcumin inhibits insulin-like growth factor 1 (IGF-1)/phosphoinositide 3-kinase (PI3K)/Akt/mTORC1 pathway which leads to apoptosis and cell cycle arrest via suppression of erythroblastosis virus transcription factor 2 and murine double minute 2 oncoprotein.	Curcumin	25-33	thymoma viral proto-oncogene 1	Mus musculus	113-116
32528227-11	2020	Both enzymatic (GST, catalase, and SOD) and nonenzymatic antioxidants (reduced GSH) were raised significantly in the presence of vitamin D3 and curcumin, which resulted in the better recovery of neuronal cells from Abeta1-42 treatment.	Curcumin	144-152	catalase	Homo sapiens	21-29
32278045-8	2020	In addition, activation of unc-51-like kinase 1 by curcumin, as a downstream target of IGF-1/PI3K/Akt/mTORC1 axis, enhances autophagy.	Curcumin	51-59	thymoma viral proto-oncogene 1	Mus musculus	98-101
31863822-0	2020	Curcumin analog, WZ37, promotes G2/M arrest and apoptosis of HNSCC cells through Akt/mTOR inhibition.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	81-84
31863822-0	2020	Curcumin analog, WZ37, promotes G2/M arrest and apoptosis of HNSCC cells through Akt/mTOR inhibition.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	85-89
32528227-11	2020	Both enzymatic (GST, catalase, and SOD) and nonenzymatic antioxidants (reduced GSH) were raised significantly in the presence of vitamin D3 and curcumin, which resulted in the better recovery of neuronal cells from Abeta1-42 treatment.	Curcumin	144-152	superoxide dismutase 1	Homo sapiens	35-38
32566072-6	2020	The treatments with curcumin and/or aminoguanidine increased the activities of the antioxidant enzymes (paraoxonase 1, superoxide dismutase, and catalase) and the levels of AGE detoxification system components (AGE-R1 receptor and glyoxalase 1).	Curcumin	20-28	catalase	Rattus norvegicus	119-153
32566072-6	2020	The treatments with curcumin and/or aminoguanidine increased the activities of the antioxidant enzymes (paraoxonase 1, superoxide dismutase, and catalase) and the levels of AGE detoxification system components (AGE-R1 receptor and glyoxalase 1).	Curcumin	20-28	glyoxalase 1	Rattus norvegicus	231-243
32438691-4	2020	In this study, we studied the curcumin analogue (3,4-Difluorobenzylidene Curcumin; CDF) encapsulated bovine serum albumin (BSA) nanoparticle for tumor targeting.	Curcumin	30-38	albumin	Homo sapiens	108-121
31914858-0	2020	Curcumin protects against white matter injury through NF-kappaB and Nrf-2 Crosstalk.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	68-73
32534511-8	2020	The levels of IL-6, IL-17, and IFN-gamma, as well as FBS, was significantly decreased in the treated group with curcumin compared to the diabetic group mice (p<0.05).	Curcumin	112-120	interleukin 6	Mus musculus	14-18
32534511-8	2020	The levels of IL-6, IL-17, and IFN-gamma, as well as FBS, was significantly decreased in the treated group with curcumin compared to the diabetic group mice (p<0.05).	Curcumin	112-120	interferon gamma	Mus musculus	31-40
32147428-7	2020	Furthermore, curcumin treatment following administration of the DHEA resulted in a significant decrease in BAX (p < 0.001) and levels of expression of Caspase3 (CASP3) protein, increased levels of B-cell lymphoma 2 (Bcl2) expression (p < 0.05), and moderated apoptosis in granulosa cells in comparison with the ones seen in the PCOS group.	Curcumin	13-21	B cell leukemia/lymphoma 2	Mus musculus	197-214
32147428-7	2020	Furthermore, curcumin treatment following administration of the DHEA resulted in a significant decrease in BAX (p < 0.001) and levels of expression of Caspase3 (CASP3) protein, increased levels of B-cell lymphoma 2 (Bcl2) expression (p < 0.05), and moderated apoptosis in granulosa cells in comparison with the ones seen in the PCOS group.	Curcumin	13-21	B cell leukemia/lymphoma 2	Mus musculus	216-220
31914858-8	2020	Cur also inhibited the hypoxia-induced upregulation of glial fibrillary acidic protein (GFAP) and neurofilament-H (NF-H) after hypoxia and downregulated the expression of pro-inflammatory cytokines like TNF-alpha and IL-1.	Curcumin	0-3	tumor necrosis factor	Rattus norvegicus	203-212
31914858-10	2020	In addition, we demonstrated that Cur exerted its neuroprotective effect through crosstalk between NF-kappaB and Nrf2 signaling pathways.	Curcumin	34-37	NFE2 like bZIP transcription factor 2	Rattus norvegicus	113-117
32457626-0	2020	The Curcumin Derivative, H10, Suppresses Hormone-Dependent Prostate Cancer by Inhibiting 17beta-Hydroxysteroid Dehydrogenase Type 3.	Curcumin	4-12	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	89-131
32734023-4	2020	The work aims to develop novel curcumin incorporated titanium dioxide nanoparticles (CTNPs) conjugated with MCP-1 antibody with the specific targeting capability to macrophage-foam cells as contrasting agent for MRI.	Curcumin	31-39	mast cell protease 1-like 1	Rattus norvegicus	108-113
32457626-2	2020	A curcumin analog, H10, was optimized for inhibiting T production in LC540 cells that stably overexpressed 17beta-HSD3 enzyme (LC540 [17beta-HSD3]) (P < 0.01), without affecting progesterone (P) synthesis.	Curcumin	2-10	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	107-118
32457626-2	2020	A curcumin analog, H10, was optimized for inhibiting T production in LC540 cells that stably overexpressed 17beta-HSD3 enzyme (LC540 [17beta-HSD3]) (P < 0.01), without affecting progesterone (P) synthesis.	Curcumin	2-10	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	134-145
32248350-9	2020	The therapeutic mechanism of curcumin in the treatment of influenza viral pneumonia is related to improving the immune function of infected mice and regulating secretion of tumor necrosis-alpha, interleukin-6, and interferon-gamma.	Curcumin	29-37	interleukin 6	Mus musculus	195-208
32375323-9	2020	Furthermore, OLETF rats exercised and fed curcumin had lower IL6, TNFalpha, and IL10 levels (indicators of inflammatory response) and lower levels of ER stress markers (BiP and CHOP) in the intestine than OLETF controls.	Curcumin	42-50	interleukin 6	Rattus norvegicus	61-64
32375323-9	2020	Furthermore, OLETF rats exercised and fed curcumin had lower IL6, TNFalpha, and IL10 levels (indicators of inflammatory response) and lower levels of ER stress markers (BiP and CHOP) in the intestine than OLETF controls.	Curcumin	42-50	tumor necrosis factor	Rattus norvegicus	66-74
32248350-9	2020	The therapeutic mechanism of curcumin in the treatment of influenza viral pneumonia is related to improving the immune function of infected mice and regulating secretion of tumor necrosis-alpha, interleukin-6, and interferon-gamma.	Curcumin	29-37	interferon gamma	Mus musculus	214-230
32004976-0	2020	Curcumin regulates the differentiation of naive CD4+T cells and activates IL-10 immune modulation against acute lung injury in mice.	Curcumin	0-8	interleukin 10	Mus musculus	74-79
32004976-13	2020	IL-17A, MPO-producing neutrophils, and NF-kappaB p65 expression in lungs of CLP mice decreased significantly after pretreatment with curcumin.	Curcumin	133-141	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	39-48
32004976-17	2020	We found curcumin could increase Treg proportions in vivo and up-regulate IL-10 expression in serum and BALF of CLP mice.	Curcumin	9-17	interleukin 10	Mus musculus	74-79
32004976-18	2020	In our in vitro experiments, we found curcumin could promote Treg differentiation and increase the production of IL-10.	Curcumin	38-46	interleukin 10	Mus musculus	113-118
32004976-21	2020	The differentiation of Tregs induced by curcumin may be one source of IL-10 immune modulation.	Curcumin	40-48	interleukin 10	Mus musculus	70-75
32073198-0	2020	Curcumin stimulates angiogenesis through VEGF and expression of HLA-G in first-trimester human placental trophoblasts.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	41-45
32370057-0	2020	Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	43-48
32370057-0	2020	Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	98-101
32370057-0	2020	Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4.	Curcumin	0-8	DNA damage inducible transcript 3	Homo sapiens	102-106
32370057-4	2020	In the present study, the chemo-sensitising effect of curcumin on TRAIL-induced apoptosis in renal carcinoma cells (RCC) was investigated.	Curcumin	54-62	TNF superfamily member 10	Homo sapiens	66-71
32370057-5	2020	The results indicate that exposure of kidney cancer ACHN cells to curcumin sensitised the cells to TRAIL, with the combination treatment of TRAIL and curcumin synergistically targeting the cancer cells without affecting the normal renal proximal tubular epithelial cells (RPTEC/TERT1) cells.	Curcumin	66-74	TNF superfamily member 10	Homo sapiens	99-104
32370057-8	2020	Overall, the results arising from this study demonstrate that curcumin has the ability to sensitise TRAIL-resistant ACHN cells to TRAIL-induced apoptosis.	Curcumin	62-70	TNF superfamily member 10	Homo sapiens	100-105
32370057-8	2020	Overall, the results arising from this study demonstrate that curcumin has the ability to sensitise TRAIL-resistant ACHN cells to TRAIL-induced apoptosis.	Curcumin	62-70	TNF superfamily member 10	Homo sapiens	130-135
32326159-8	2020	The nanoformulation containing curcumin and methotrexate (NCUR/MTX-2) statistically decreased the cell viability of Calu-3.	Curcumin	31-39	metaxin 2	Homo sapiens	63-68
31952056-0	2020	GANT61 and Curcumin loaded PLGA Nanoparticles for GLI-1 and PI3K/Akt Mediated Inhibition in Breast Adenocarcinoma.	Curcumin	11-19	AKT serine/threonine kinase 1	Homo sapiens	65-68
32124251-0	2020	Nrf2/ARE is a key pathway for curcumin-mediated protection of TMJ chondrocytes from oxidative stress and inflammation.	Curcumin	30-38	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
32124251-4	2020	Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment.	Curcumin	0-8	interleukin 6	Homo sapiens	74-78
32124251-4	2020	Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	90-95
32124251-4	2020	Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment.	Curcumin	0-8	matrix metallopeptidase 3	Homo sapiens	143-148
32124251-4	2020	Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment.	Curcumin	0-8	matrix metallopeptidase 13	Homo sapiens	157-163
32124251-4	2020	Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment.	Curcumin	0-8	collagen type II alpha 1 chain	Homo sapiens	254-260
32124251-6	2020	Pathway analysis demonstrated that the ROS/Nrf2/HO-1-SOD2-NQO-1-GCLC signaling axis is a key axis through which curcumin activates the Nrf2/ARE pathway in TMJ inflammatory chondrocytes.	Curcumin	112-120	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
32124251-6	2020	Pathway analysis demonstrated that the ROS/Nrf2/HO-1-SOD2-NQO-1-GCLC signaling axis is a key axis through which curcumin activates the Nrf2/ARE pathway in TMJ inflammatory chondrocytes.	Curcumin	112-120	NAD(P)H quinone dehydrogenase 1	Homo sapiens	58-63
32124251-6	2020	Pathway analysis demonstrated that the ROS/Nrf2/HO-1-SOD2-NQO-1-GCLC signaling axis is a key axis through which curcumin activates the Nrf2/ARE pathway in TMJ inflammatory chondrocytes.	Curcumin	112-120	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
32124251-7	2020	Curcumin-induced anti-inflammatory and cartilage protective effects were significantly abrogated by specific Nrf2 siRNA.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
32124251-9	2020	Our experimental results indicate that curcumin inhibits inflammation, oxidative stress, and the matrix degradation of TMJ inflammatory chondrocytes through the Nrf2/ARE signaling pathway, thereby exerting cartilage protective effects.	Curcumin	39-47	NFE2 like bZIP transcription factor 2	Homo sapiens	161-165
31802559-7	2020	Furthermore, the curcumin supplementation reduced the serum hs-CRP concentration (-6.3 +- 13.6 vs. 3.7 +- 11.6 mug/ml; p = .01) and ESR levels significantly (-1.6 +- 2.7 vs. -0.09 +- 2.4 mm/hr; p = .02) in comparison with the control group.	Curcumin	17-25	C-reactive protein	Homo sapiens	63-66
31802559-9	2020	CONCLUSIONS: Consumption of the curcumin supplement, along with drug therapy, is associated with significant improvement of the clinical outcomes, quality of life, hs-CRP, and ESR in patients with mild-to-moderate UC.	Curcumin	32-40	C-reactive protein	Homo sapiens	167-170
31917699-0	2020	Combination treatment of bicalutamide and curcumin has a strong therapeutic effect on androgen receptor-positive triple-negative breast cancers.	Curcumin	42-50	androgen receptor	Homo sapiens	86-103
32017935-6	2020	The aim of this review is to provide the newest insights in the preclinical and clinical evidence of Nrf2 induction in the regeneration of the antioxidant response and attenuation of inflammation in MS. Preclinical studies have indicated that activators of this pathway, such as epigallocatechin gallate (EGCG), curcumin, melatonin, resveratrol, and sulforaphane might be a promising therapeutic option in amelioration of MS symptoms, nevertheless, the efficacy and safety of these compounds have to be confirmed in future clinical trials.	Curcumin	312-320	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
32186843-6	2020	The interaction of CM and serum albumin (the quantitative binding force) was analyzed.	Curcumin	19-21	albumin	Homo sapiens	26-39
32037797-7	2020	Curcumin supplementation at 200 mg/kg up-regulated the levels of AKT, NGF, mTOR, Nrf2 and HO-1 mRNA, and concomitantly down-regulated Bax, caspases-3 and -9 mRNA; it also decreased caspase-3 and caspase-9 activity.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	65-68
32037797-7	2020	Curcumin supplementation at 200 mg/kg up-regulated the levels of AKT, NGF, mTOR, Nrf2 and HO-1 mRNA, and concomitantly down-regulated Bax, caspases-3 and -9 mRNA; it also decreased caspase-3 and caspase-9 activity.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	81-85
32037797-7	2020	Curcumin supplementation at 200 mg/kg up-regulated the levels of AKT, NGF, mTOR, Nrf2 and HO-1 mRNA, and concomitantly down-regulated Bax, caspases-3 and -9 mRNA; it also decreased caspase-3 and caspase-9 activity.	Curcumin	0-8	heme oxygenase 1	Mus musculus	90-94
32037797-8	2020	In summary, for the first time, our study reveals that the protective effect of oral curcumin on colistin induced peripheral neurotoxicity is associated with the activation of NGF/Akt and Nrf2/HO-1 pathways and inhibition of oxidative stress.	Curcumin	85-93	thymoma viral proto-oncogene 1	Mus musculus	180-183
32037797-8	2020	In summary, for the first time, our study reveals that the protective effect of oral curcumin on colistin induced peripheral neurotoxicity is associated with the activation of NGF/Akt and Nrf2/HO-1 pathways and inhibition of oxidative stress.	Curcumin	85-93	nuclear factor, erythroid derived 2, like 2	Mus musculus	188-192
32037797-8	2020	In summary, for the first time, our study reveals that the protective effect of oral curcumin on colistin induced peripheral neurotoxicity is associated with the activation of NGF/Akt and Nrf2/HO-1 pathways and inhibition of oxidative stress.	Curcumin	85-93	heme oxygenase 1	Mus musculus	193-197
32328199-0	2020	Synergistic Effects of Curcumin and 5-Fluorouracil on the Hepatocellular Carcinoma In vivo and vitro through regulating the expression of COX-2 and NF-kappaB.	Curcumin	23-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
32328199-0	2020	Synergistic Effects of Curcumin and 5-Fluorouracil on the Hepatocellular Carcinoma In vivo and vitro through regulating the expression of COX-2 and NF-kappaB.	Curcumin	23-31	nuclear factor kappa B subunit 1	Homo sapiens	148-157
31917699-10	2020	Curcumin treatment inhibited androgen receptor protein expression in AR triple-negative breast cancer cells.	Curcumin	0-8	androgen receptor	Homo sapiens	29-46
32069075-2	2020	In this study, we established hypoxia-reoxygenation in neonate rat myocardial cells and employed gamma-secretase inhibitor and curcumin to inhibit and activate the Notch1 and Keap1-Nrf2 signaling pathways, respectively.	Curcumin	127-135	NFE2 like bZIP transcription factor 2	Rattus norvegicus	181-185
32220355-9	2020	Additionally, curcumin administration up-regulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) (P = 0.03) and low-density lipoprotein receptor (LDLR) (P < 0.001) compared with the placebo.	Curcumin	14-22	peroxisome proliferator activated receptor gamma	Homo sapiens	120-130
32220355-10	2020	CONCLUSIONS: Overall, curcumin administration for 12 weeks to women with PCOS had beneficial effects on body weight, glycemic control, serum lipids except triglycerides and VLDL-cholesterol levels, and gene expression of PPAR-gamma and LDLR.	Curcumin	22-30	peroxisome proliferator activated receptor gamma	Homo sapiens	221-231
32220355-9	2020	Additionally, curcumin administration up-regulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) (P = 0.03) and low-density lipoprotein receptor (LDLR) (P < 0.001) compared with the placebo.	Curcumin	14-22	peroxisome proliferator activated receptor gamma	Homo sapiens	70-118
31911391-2	2020	In this work, the solubility and bioavailability of curcumin (Cur) were enhanced by entrapment in a polyamidoamine (PAMAM) dendrimer, and a polyplex was formed by grafting Bcl-2 siRNA onto the surface amine groups to produce PAMAM-Cur/Bcl-2 siRNA nanoparticles (NPs).	Curcumin	52-60	BCL2 apoptosis regulator	Homo sapiens	172-177
31911391-2	2020	In this work, the solubility and bioavailability of curcumin (Cur) were enhanced by entrapment in a polyamidoamine (PAMAM) dendrimer, and a polyplex was formed by grafting Bcl-2 siRNA onto the surface amine groups to produce PAMAM-Cur/Bcl-2 siRNA nanoparticles (NPs).	Curcumin	52-60	BCL2 apoptosis regulator	Homo sapiens	235-240
31891282-0	2020	Post-treatment curcumin reduced ischemia-reperfusion-induced pulmonary injury via the Notch2/Hes-1 pathway.	Curcumin	15-23	notch receptor 2	Homo sapiens	86-92
32124937-0	2020	Curcumin exerts protective effects against hypoxia-reoxygenation injury via the enhancement of apurinic/apyrimidinic endonuclease 1 in SH-SY5Y cells: Involvement of the PI3K/AKT pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	174-177
32124937-8	2020	Furthermore, curcumin mitigated the OGD/R-induced activation of phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	117-120
32307668-7	2020	In addition, alphaSMA protein in the cells cultured on the nanofibers/curcumin expressed significantly higher than those cells cultured on the nanofibers without curcumin.	Curcumin	70-78	actin alpha 1, skeletal muscle	Homo sapiens	13-21
32307668-7	2020	In addition, alphaSMA protein in the cells cultured on the nanofibers/curcumin expressed significantly higher than those cells cultured on the nanofibers without curcumin.	Curcumin	162-170	actin alpha 1, skeletal muscle	Homo sapiens	13-21
31954127-6	2020	The IC50 values of 6-TG, 6-TG-CNPs, and curcumin for MCF-7 were 23.09, 17.82, and 15.73 muM, respectively.	Curcumin	40-48	latexin	Homo sapiens	88-91
31954127-7	2020	Likewise, IC50 values of 6-TG, 6-TG-CNPs, and curcumin for PA-1 were 5.81, 3.92, and 12.89 muM, respectively.	Curcumin	46-54	latexin	Homo sapiens	91-94
32020381-11	2020	However, despite the low CUR plasma concentrations, all three oral CUR formulations displayed PD response in the induction of Nrf2-mediated antioxidant genes, suggesting the potential of oral CUR contributing to the overall health beneficial effects of oral CUR.	Curcumin	67-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	126-130
32237999-0	2020	Curcumin protects murine lung mesenchymal stem cells from H2O2 by modulating the Akt/Nrf2/HO-1 pathway.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	81-84
32237999-0	2020	Curcumin protects murine lung mesenchymal stem cells from H2O2 by modulating the Akt/Nrf2/HO-1 pathway.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
32237999-0	2020	Curcumin protects murine lung mesenchymal stem cells from H2O2 by modulating the Akt/Nrf2/HO-1 pathway.	Curcumin	0-8	heme oxygenase 1	Mus musculus	90-94
32020381-11	2020	However, despite the low CUR plasma concentrations, all three oral CUR formulations displayed PD response in the induction of Nrf2-mediated antioxidant genes, suggesting the potential of oral CUR contributing to the overall health beneficial effects of oral CUR.	Curcumin	67-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	126-130
32020381-11	2020	However, despite the low CUR plasma concentrations, all three oral CUR formulations displayed PD response in the induction of Nrf2-mediated antioxidant genes, suggesting the potential of oral CUR contributing to the overall health beneficial effects of oral CUR.	Curcumin	67-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	126-130
31980182-0	2020	Curcumin exerts anti-tumor effects on diffuse large B cell lymphoma via regulating PPARgamma expression.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	83-92
32256716-12	2020	Besides, the results of the present study suggested that nano-curcumin supplementation significantly decreases serum concentrations of malondialdehyde (MDA), and hs-CRP in subjects with metabolic syndrome.	Curcumin	62-70	C-reactive protein	Homo sapiens	165-168
32373388-0	2020	Biophysical interactions between silver nanoparticle-albumin interface and curcumin.	Curcumin	75-83	albumin	Homo sapiens	53-60
32821745-0	2020	The Effect of Nano-Curcumin Supplementation on Pentraxin 3 Gene Expression and Serum Level in Migraine Patients.	Curcumin	19-27	pentraxin 3	Homo sapiens	47-58
32821745-1	2020	Background: This study was designed to investigate the effect of nano-curcumin supplementation on pentraxin 3 (PTX3) gene exp ression and serum level in migraine patients.	Curcumin	70-78	pentraxin 3	Homo sapiens	98-109
32821745-1	2020	Background: This study was designed to investigate the effect of nano-curcumin supplementation on pentraxin 3 (PTX3) gene exp ression and serum level in migraine patients.	Curcumin	70-78	pentraxin 3	Homo sapiens	111-115
32821745-4	2020	Results: After two months of treatment, PTX3 gene expression and serum levels were both significantly less in the nano-curcumin than in the placebo group (P= 0.01 and P< 0.001, respectively).	Curcumin	119-127	pentraxin 3	Homo sapiens	40-44
32821745-6	2020	Conclusion: Curcumin may have a potential inhibitory effect on PTX3 gene expression and serum levels in migraine disease and can be considered as an efficient therapy in migraine management.	Curcumin	12-20	pentraxin 3	Homo sapiens	63-67
32228565-0	2020	Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter.	Curcumin	39-47	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
32228565-5	2020	We evaluated the effects of UPM and/or curcumin on the expression of phosphorylated ERK, Nrf2, HO-1, and SOD2 in fibroblasts by Western blotting.	Curcumin	39-47	mitogen-activated protein kinase 1	Homo sapiens	84-87
32228565-5	2020	We evaluated the effects of UPM and/or curcumin on the expression of phosphorylated ERK, Nrf2, HO-1, and SOD2 in fibroblasts by Western blotting.	Curcumin	39-47	NFE2 like bZIP transcription factor 2	Homo sapiens	89-93
32228565-9	2020	The UPM-induced activation of ERK was inhibited by curcumin.	Curcumin	51-59	mitogen-activated protein kinase 1	Homo sapiens	30-33
32228565-10	2020	Nrf2 production was also promoted to increase the expression of HO-1 and SOD2 by curcumin.	Curcumin	81-89	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
31980182-2	2020	Curcumin harbored anti-tumor potential in various cancers, here, we investigated the possible effects and mechanism of curcumin on human DLBCL in vitro and in vivo, we found that curcumin inhibited cell viability in a concentration and time dependent manner, promoted cell apoptosis and arrested cell cycle at G2 phase, and these effects were mediated by PPARgamma promotion and Akt/mTOR pathway inactivation.	Curcumin	179-187	peroxisome proliferator activated receptor gamma	Homo sapiens	355-364
31980182-2	2020	Curcumin harbored anti-tumor potential in various cancers, here, we investigated the possible effects and mechanism of curcumin on human DLBCL in vitro and in vivo, we found that curcumin inhibited cell viability in a concentration and time dependent manner, promoted cell apoptosis and arrested cell cycle at G2 phase, and these effects were mediated by PPARgamma promotion and Akt/mTOR pathway inactivation.	Curcumin	179-187	AKT serine/threonine kinase 1	Homo sapiens	379-382
31980182-2	2020	Curcumin harbored anti-tumor potential in various cancers, here, we investigated the possible effects and mechanism of curcumin on human DLBCL in vitro and in vivo, we found that curcumin inhibited cell viability in a concentration and time dependent manner, promoted cell apoptosis and arrested cell cycle at G2 phase, and these effects were mediated by PPARgamma promotion and Akt/mTOR pathway inactivation.	Curcumin	179-187	mechanistic target of rapamycin kinase	Homo sapiens	383-387
31980182-3	2020	Furthermore, effects of curcumin on human DLBCL cells could be partly rescued by PPARgamma antagonist GW9662, and enhanced by PPARgamma agonist rosiglitazone.	Curcumin	24-32	peroxisome proliferator activated receptor gamma	Homo sapiens	81-90
31980182-3	2020	Furthermore, effects of curcumin on human DLBCL cells could be partly rescued by PPARgamma antagonist GW9662, and enhanced by PPARgamma agonist rosiglitazone.	Curcumin	24-32	peroxisome proliferator activated receptor gamma	Homo sapiens	126-135
31980182-4	2020	Taken together, our results demonstrated that curcumin inhibited the proliferation of DLBCL cells by up-regulating the expression of PPARgamma, and our results might provide novel therapeutic approaches and a potential target to DLBCL treatment.	Curcumin	46-54	peroxisome proliferator activated receptor gamma	Homo sapiens	133-142
32126993-6	2020	Additionally, CUR,DMC, and BDMC induced the apoptosis of HOS cells through activation of Smad 2/3 or repression of Akt signaling pathway.	Curcumin	14-17	AKT serine/threonine kinase 1	Homo sapiens	115-118
32207596-9	2022	After treatment with low dose curcumin, the level of miRNA-146a in APP/PS1 mice decreased significantly, and the expression of A beta and APP/PS1 in temporal lobe of mice detected by Western blot decreased significantly, the levels of IL-1 beta and iNOS protein decreased significantly, and the protein of CFH increased signifanctly.	Curcumin	30-38	nitric oxide synthase 2, inducible	Mus musculus	249-253
32143311-7	2020	In addition, curcumin treatment reduced activation of the NFkB, MAPK, AKT and pBAD pathways either systemically, or within the inflamed kidneys.	Curcumin	13-21	thymoma viral proto-oncogene 1	Mus musculus	70-73
32184643-0	2020	Curcumin Inhibited Podocyte Cell Apoptosis and Accelerated Cell Autophagy in Diabetic Nephropathy via Regulating Beclin1/UVRAG/Bcl2.	Curcumin	0-8	B cell leukemia/lymphoma 2	Mus musculus	127-131
32184643-12	2020	The autophagy-related proteins LC3, p62, Beclin1, UVRAG and ATG5 were significantly affected in DN mice by curcumin, along with reducing expression of pro-apoptotic protein Bax and caspase-3 and increasing anti-apoptotic protein Bcl-2.	Curcumin	107-115	B cell leukemia/lymphoma 2	Mus musculus	229-234
32184643-15	2020	Discussion: Together, the results showed that curcumin inhibited podocyte apoptosis and accelerated cell autophagy via regulating Beclin1/UVRAG/Bcl2.	Curcumin	46-54	B cell leukemia/lymphoma 2	Mus musculus	144-148
31970343-0	2020	Signal-off electrochemiluminescence immunosensors based on the quenching effect between curcumin-conjugated Au nanoparticles encapsulated in ZIF-8 and CdS-decorated TiO2 nanobelts for insulin detection.	Curcumin	88-96	insulin	Homo sapiens	184-191
31970343-1	2020	A new strategy for the highly sensitive electrochemiluminescence (ECL) detection of insulin was developed based on curcumin-conjugated Au nanoparticles wrapped in zeolitic Zn2+-imidazolate cross-linked framework nanoparticles (Au-Cur/ZIF-8) quenching the ECL of CdS-decorated TiO2 nanobelts (CdS@TiO2).	Curcumin	115-123	insulin	Homo sapiens	84-91
31881321-7	2020	RESULTS: The consequences of this study revealed that curcumin activated Nrf2, inhibited NF-kappaB pathway and up-regulated podocin in DOX-induced podocyte.	Curcumin	54-62	NFE2 like bZIP transcription factor 2	Rattus norvegicus	73-77
31881321-7	2020	RESULTS: The consequences of this study revealed that curcumin activated Nrf2, inhibited NF-kappaB pathway and up-regulated podocin in DOX-induced podocyte.	Curcumin	54-62	NPHS2 stomatin family member, podocin	Rattus norvegicus	124-131
31881321-9	2020	Further observation by electron microscopy and detection showed that curcumin can improve renal function and podocyte injury, which may be related to the repairment of mRNA expression and podocin protein.	Curcumin	69-77	NPHS2 stomatin family member, podocin	Rattus norvegicus	188-195
31881321-11	2020	In addition, the oxidative stress state of kidney in NS rats was considerably reversed by curcumin, which may be achieved by activating Nrf2 and increasing the expression of antioxidant enzymes HO-1, NQO-1.	Curcumin	90-98	NFE2 like bZIP transcription factor 2	Rattus norvegicus	136-140
31881321-11	2020	In addition, the oxidative stress state of kidney in NS rats was considerably reversed by curcumin, which may be achieved by activating Nrf2 and increasing the expression of antioxidant enzymes HO-1, NQO-1.	Curcumin	90-98	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	200-205
32126993-0	2020	Curcumin, demethoxycurcumin, and bisdemethoxycurcumin induced caspase-dependent and -independent apoptosis via Smad or Akt signaling pathways in HOS cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	119-122
31981960-0	2020	Dimethyl fumarate and curcumin attenuate hepatic ischemia/reperfusion injury via Nrf2/HO-1 activation and anti-inflammatory properties.	Curcumin	22-30	NFE2 like bZIP transcription factor 2	Rattus norvegicus	81-85
31797403-0	2020	Curcumin improves asthenozoospermia by inhibiting reactive oxygen species reproduction through nuclear factor erythroid 2-related factor 2 activation.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	95-138
31797403-8	2020	Our results have shown that curcumin might protect spermatozoa by regulating Nrf2 level.	Curcumin	28-36	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
31545905-11	2020	In MDA-MB231 cells, incubation with curcumin decreased AKT1 and p-AKT1 (Thr308) levels.	Curcumin	36-44	AKT serine/threonine kinase 1	Homo sapiens	55-59
31545905-11	2020	In MDA-MB231 cells, incubation with curcumin decreased AKT1 and p-AKT1 (Thr308) levels.	Curcumin	36-44	AKT serine/threonine kinase 1	Homo sapiens	66-70
31545905-12	2020	Incubation with curcumin and quercetin decreased the EGFR levels.	Curcumin	16-24	epidermal growth factor receptor	Homo sapiens	53-57
31958483-0	2020	The curcumin analogue WZ35 affects glycolysis inhibition of gastric cancer cells through ROS-YAP-JNK pathway.	Curcumin	4-12	mitogen-activated protein kinase 8	Homo sapiens	97-100
31972171-0	2020	Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	34-38
31972171-1	2020	The present study was aimed to investigate the effects of curcumin, a representative chemopreventive phytochemical with pronounced antioxidant and anti-inflammatory properties, on activation of Nrf2 and its target protein heme oxygenase-1 (HO-1) in mouse skin in vivo and in cultured murine epidermal cells.	Curcumin	58-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	194-198
31972171-1	2020	The present study was aimed to investigate the effects of curcumin, a representative chemopreventive phytochemical with pronounced antioxidant and anti-inflammatory properties, on activation of Nrf2 and its target protein heme oxygenase-1 (HO-1) in mouse skin in vivo and in cultured murine epidermal cells.	Curcumin	58-66	heme oxygenase 1	Mus musculus	222-238
31972171-1	2020	The present study was aimed to investigate the effects of curcumin, a representative chemopreventive phytochemical with pronounced antioxidant and anti-inflammatory properties, on activation of Nrf2 and its target protein heme oxygenase-1 (HO-1) in mouse skin in vivo and in cultured murine epidermal cells.	Curcumin	58-66	heme oxygenase 1	Mus musculus	240-244
31972171-2	2020	Treatment of mouse epidermal JB-6 cells with curcumin resulted in the induction of HO-1 expression, and this was abrogated in cells transiently transfected with Nrf2 siRNA.	Curcumin	45-53	NFE2 like bZIP transcription factor 2	Homo sapiens	161-165
31972171-3	2020	While curcumin treatment increased protein expression of Nrf2, it failed to did not alter the steady-state level of the Nrf2 mRNA transcript.	Curcumin	6-14	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
31972171-4	2020	Treatment of cells with curcumin stabilized Nrf2 by inhibiting ubiquitination and subsequent 26S proteasomal degradation of this transcription factor.	Curcumin	24-32	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
31972171-6	2020	Cells transfected with a mutant Keap1 protein in which cysteine 151 is replaced by serine exhibited marked reduction in curcumin-induced Nrf2 transactivation.	Curcumin	120-128	NFE2 like bZIP transcription factor 2	Homo sapiens	137-141
31972171-7	2020	Mass spectrometric analysis revealed that curcumin binds to Keap1 Cys151, supporting that this amino acid is a critical target for curcumin modification of Keap1, which facilitates the liberation of Nrf2.	Curcumin	42-50	NFE2 like bZIP transcription factor 2	Homo sapiens	199-203
31972171-7	2020	Mass spectrometric analysis revealed that curcumin binds to Keap1 Cys151, supporting that this amino acid is a critical target for curcumin modification of Keap1, which facilitates the liberation of Nrf2.	Curcumin	131-139	NFE2 like bZIP transcription factor 2	Homo sapiens	199-203
31972171-8	2020	Thus, it is likely that the alpha,beta-unsaturated carbonyl moiety of curcumin is critical essential for its binding to Keap1 and stabilization of Nrf2 by hampering ubiquitination and proteasomal degradation.	Curcumin	70-78	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
30796508-2	2020	The present study aimed to explore the effect of phosphatidylserine- and piperine-containing curcumin phytosomes on a large number of metabolic parameters related to insulin resistance, in the context of a randomized double-blind placebo-controlled trial involving 80 overweight subjects with suboptimal fasting plasma glucose.	Curcumin	93-101	insulin	Homo sapiens	166-173
30796508-4	2020	RESULTS: After 56-day treatment, the curcumin-treated group experienced a significant improvement in fasting plasma insulin (FPI), HOMA index, waist circumference, blood pressure, triglycerides (TG), HDL-C, liver transaminases, gamma-GT, index of liver steatosis and serum cortisol compared to the baseline.	Curcumin	37-45	insulin	Homo sapiens	116-123
32118214-1	2020	In this study, demethylcurcumin (DC), a minor constituent in curcuminoids, showed better anti-acetylcholinesterase (anti-AChE) activities, anti-amyloid beta peptide aggregation, neuroprotective activities in 6-hydroxydopamine-treated SH-SY5Y cell models, and anti-nitric oxide production in lipopolysaccharide-treated RAW 264.7 macrophages than those of curcumin.	Curcumin	23-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	94-114
32118214-1	2020	In this study, demethylcurcumin (DC), a minor constituent in curcuminoids, showed better anti-acetylcholinesterase (anti-AChE) activities, anti-amyloid beta peptide aggregation, neuroprotective activities in 6-hydroxydopamine-treated SH-SY5Y cell models, and anti-nitric oxide production in lipopolysaccharide-treated RAW 264.7 macrophages than those of curcumin.	Curcumin	23-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	121-125
32118214-1	2020	In this study, demethylcurcumin (DC), a minor constituent in curcuminoids, showed better anti-acetylcholinesterase (anti-AChE) activities, anti-amyloid beta peptide aggregation, neuroprotective activities in 6-hydroxydopamine-treated SH-SY5Y cell models, and anti-nitric oxide production in lipopolysaccharide-treated RAW 264.7 macrophages than those of curcumin.	Curcumin	23-31	amyloid beta precursor protein	Homo sapiens	144-156
31843707-9	2020	Curcumin activated AMPK-JNK signaling, which mediated both mTOR inhibition and Bcl-2 upregulation and in turn enhanced autophagy and suppressed apoptosis, respectively.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	59-63
32036572-14	2020	Curcumin inhibits H2O2-induced increase of APP cleavage through beta-cleavage pathway and of intracellular Abeta production.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	107-112
32036572-15	2020	These results imply that curcumin can be used to treat AD through inhibiting oxidative damage-induced APP beta-cleavage and intracellular Abeta generation.	Curcumin	25-33	amyloid beta precursor protein	Homo sapiens	138-143
31612257-9	2020	Cisplatin-activated Hh signaling which was blocked by both Ars and curcumin as demonstrated by decreased mRNA levels of Shh, Smo, and Ptch and suppressed renal Gli1 and Gli2 protein levels.	Curcumin	67-75	smoothened, frizzled class receptor	Rattus norvegicus	125-128
31843707-9	2020	Curcumin activated AMPK-JNK signaling, which mediated both mTOR inhibition and Bcl-2 upregulation and in turn enhanced autophagy and suppressed apoptosis, respectively.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	79-84
31690485-3	2020	The facile fluorescent method was demonstrated to detect Cur in the range of 0-2600 muM with a detection limit of 0.13 muM.	Curcumin	57-60	latexin	Homo sapiens	84-87
32161501-0	2020	Curcumin Inhibits the Tumorigenesis of Breast Cancer by Blocking Tafazzin/Yes-Associated Protein Axis.	Curcumin	0-8	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	65-73
32161501-1	2020	Purpose: This study was aimed to explore the anti-tumor effect of curcumin on breast cancer (BC) and the underlying mechanism involving Tafazzin (TAZ)/Yes-associated protein (YAP) axis.	Curcumin	66-74	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	136-144
32161501-1	2020	Purpose: This study was aimed to explore the anti-tumor effect of curcumin on breast cancer (BC) and the underlying mechanism involving Tafazzin (TAZ)/Yes-associated protein (YAP) axis.	Curcumin	66-74	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	146-149
32161501-2	2020	Methods: Different concentrations of curcumin (0, 10, 20 and 30 muM) were used to treat BC cells (MCF-7 and MDA-MB-231 cells).	Curcumin	37-45	latexin	Homo sapiens	64-67
32161501-6	2020	Results: Curcumin (20 and 30 muM) inhibited the proliferation, migration and invasion, and promoted the apoptosis of MCF-7 and MDA-MB-231 cells.	Curcumin	9-17	latexin	Homo sapiens	29-32
32161501-7	2020	Curcumin decreased the protein expression of TAZ and YAP in MCF-7 and MDA-MB-231 cells.	Curcumin	0-8	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	45-48
32161501-9	2020	In addition, curcumin (100, 200 and 300 mg/kg/d) inhibited the growth of tumor xenografts in mice, and down-regulated the protein expression of TAZ and YAP in tumor xenografts.	Curcumin	13-21	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	144-147
32161501-11	2020	Conclusion: Curcumin inhibited the tumorigenesis of BC by blocking TAZ/YAP axis.	Curcumin	12-20	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	67-70
32114280-0	2020	Curcumin mediates attenuation of pro-inflammatory interferon gamma and interleukin 17 cytokine responses in psoriatic disease, strengthening its role as a dietary immunosuppressant.	Curcumin	0-8	interferon gamma	Homo sapiens	50-66
32114280-3	2020	We hypothesized that curcumin could inhibit interferon (IFN)-gamma and interleukin (IL)-17 production in peripheral blood mononuclear cells from patients with psoriasis and psoriatic arthritis (PsA).	Curcumin	21-29	interferon gamma	Homo sapiens	44-66
32114280-4	2020	To this end, we assessed the in vitro effect of curcumin on IFN-gamma production by cluster differentiation (CD)4(+), CD8(+) T cells, natural killer (NK) and NKT cells and on IL-17 production by CD4(+) T cells from 34 patients with psoriatic disease (22 with psoriasis and 12 with PsA); 15 normal subjects were included as healthy controls.	Curcumin	48-56	interferon gamma	Homo sapiens	60-69
32114280-4	2020	To this end, we assessed the in vitro effect of curcumin on IFN-gamma production by cluster differentiation (CD)4(+), CD8(+) T cells, natural killer (NK) and NKT cells and on IL-17 production by CD4(+) T cells from 34 patients with psoriatic disease (22 with psoriasis and 12 with PsA); 15 normal subjects were included as healthy controls.	Curcumin	48-56	CD4 molecule	Homo sapiens	84-113
32114280-5	2020	We also assessed the effect of curcumin on signal transducer and activator of transcription (STAT)3 activation.	Curcumin	31-39	signal transducer and activator of transcription 3	Homo sapiens	43-99
32114280-6	2020	Curcumin significantly decreased, in a dose dependent manner, IFNgamma-production by CD4(+) and CD8(+) T cells, and NK and NKT cells in patients with psoriatic disease and healthy controls.	Curcumin	0-8	interferon gamma	Homo sapiens	62-70
32114280-6	2020	Curcumin significantly decreased, in a dose dependent manner, IFNgamma-production by CD4(+) and CD8(+) T cells, and NK and NKT cells in patients with psoriatic disease and healthy controls.	Curcumin	0-8	CD4 molecule	Homo sapiens	85-88
32114280-8	2020	At the molecular level, curcumin increased STAT3 serine 727 phosphorylation intensity and p-STAT3(+) CD4(+) T cells in patients with PsA and psoriasis.	Curcumin	24-32	signal transducer and activator of transcription 3	Homo sapiens	43-48
32114280-8	2020	At the molecular level, curcumin increased STAT3 serine 727 phosphorylation intensity and p-STAT3(+) CD4(+) T cells in patients with PsA and psoriasis.	Curcumin	24-32	signal transducer and activator of transcription 3	Homo sapiens	92-97
32114280-8	2020	At the molecular level, curcumin increased STAT3 serine 727 phosphorylation intensity and p-STAT3(+) CD4(+) T cells in patients with PsA and psoriasis.	Curcumin	24-32	CD4 molecule	Homo sapiens	101-104
32114280-9	2020	In conclusion, curcumin in vitro inhibits pro-inflammatory IFN-gamma and IL-17 production in psoriatic disease, and this may strengthen its role as a dietary immunosuppressant in patients with this disease.	Curcumin	15-23	interferon gamma	Homo sapiens	59-68
32107363-0	2020	Curcumin Suppresses Apoptosis and Inflammation in Hypoxia/Reperfusion-Exposed Neurons via Wnt Signaling Pathway.	Curcumin	0-8	Wnt family member 5A	Homo sapiens	90-93
32107363-13	2020	Moreover, curcumin pre-treatment significantly decreased expression levels of Wnt5a, IL6, TNFalpha, and phosphorylation level of JNK1, as well as the nuclear translocation level of NF-kappaB in H/R-exposed neurons, in a concentration-dependent manner.	Curcumin	10-18	Wnt family member 5A	Homo sapiens	78-83
32107363-13	2020	Moreover, curcumin pre-treatment significantly decreased expression levels of Wnt5a, IL6, TNFalpha, and phosphorylation level of JNK1, as well as the nuclear translocation level of NF-kappaB in H/R-exposed neurons, in a concentration-dependent manner.	Curcumin	10-18	interleukin 6	Homo sapiens	85-88
32107363-13	2020	Moreover, curcumin pre-treatment significantly decreased expression levels of Wnt5a, IL6, TNFalpha, and phosphorylation level of JNK1, as well as the nuclear translocation level of NF-kappaB in H/R-exposed neurons, in a concentration-dependent manner.	Curcumin	10-18	tumor necrosis factor	Homo sapiens	90-98
32107363-13	2020	Moreover, curcumin pre-treatment significantly decreased expression levels of Wnt5a, IL6, TNFalpha, and phosphorylation level of JNK1, as well as the nuclear translocation level of NF-kappaB in H/R-exposed neurons, in a concentration-dependent manner.	Curcumin	10-18	mitogen-activated protein kinase 8	Homo sapiens	129-133
32107363-13	2020	Moreover, curcumin pre-treatment significantly decreased expression levels of Wnt5a, IL6, TNFalpha, and phosphorylation level of JNK1, as well as the nuclear translocation level of NF-kappaB in H/R-exposed neurons, in a concentration-dependent manner.	Curcumin	10-18	nuclear factor kappa B subunit 1	Homo sapiens	181-190
32107363-14	2020	CONCLUSIONS Curcumin exerted neuro-protective effects against H/R-induced neuron apoptosis and inflammation by inhibiting activation of the Wnt/JNK1 signaling pathway.	Curcumin	12-20	Wnt family member 5A	Homo sapiens	140-143
32107363-14	2020	CONCLUSIONS Curcumin exerted neuro-protective effects against H/R-induced neuron apoptosis and inflammation by inhibiting activation of the Wnt/JNK1 signaling pathway.	Curcumin	12-20	mitogen-activated protein kinase 8	Homo sapiens	144-148
31690485-4	2020	And facile paper sensor of Cur was fabricated and displayed at concentration of 0 muM, 100 muM, 200 muM, 300 muM, 400 muM, 500 muM and 600 muM, respectively.	Curcumin	27-30	latexin	Homo sapiens	91-94
31690485-4	2020	And facile paper sensor of Cur was fabricated and displayed at concentration of 0 muM, 100 muM, 200 muM, 300 muM, 400 muM, 500 muM and 600 muM, respectively.	Curcumin	27-30	latexin	Homo sapiens	91-94
31690485-4	2020	And facile paper sensor of Cur was fabricated and displayed at concentration of 0 muM, 100 muM, 200 muM, 300 muM, 400 muM, 500 muM and 600 muM, respectively.	Curcumin	27-30	latexin	Homo sapiens	91-94
31690485-4	2020	And facile paper sensor of Cur was fabricated and displayed at concentration of 0 muM, 100 muM, 200 muM, 300 muM, 400 muM, 500 muM and 600 muM, respectively.	Curcumin	27-30	latexin	Homo sapiens	91-94
31690485-4	2020	And facile paper sensor of Cur was fabricated and displayed at concentration of 0 muM, 100 muM, 200 muM, 300 muM, 400 muM, 500 muM and 600 muM, respectively.	Curcumin	27-30	latexin	Homo sapiens	91-94
32075287-11	2020	The use of curcumin reduces the subjective perception of the intensity of muscle pain; reduces muscle damage through the decrease of creatine kinase (CK); increases muscle performance; has an anti-inflammatory effect by modulating the pro-inflammatory cytokines, such as TNF-alpha, IL-6, and IL-8; and may have a slight antioxidant effect.	Curcumin	11-19	tumor necrosis factor	Homo sapiens	271-280
31690485-3	2020	The facile fluorescent method was demonstrated to detect Cur in the range of 0-2600 muM with a detection limit of 0.13 muM.	Curcumin	57-60	latexin	Homo sapiens	119-122
31690485-4	2020	And facile paper sensor of Cur was fabricated and displayed at concentration of 0 muM, 100 muM, 200 muM, 300 muM, 400 muM, 500 muM and 600 muM, respectively.	Curcumin	27-30	latexin	Homo sapiens	82-85
31690485-4	2020	And facile paper sensor of Cur was fabricated and displayed at concentration of 0 muM, 100 muM, 200 muM, 300 muM, 400 muM, 500 muM and 600 muM, respectively.	Curcumin	27-30	latexin	Homo sapiens	91-94
32046055-10	2020	In addition, we found BaP plus curcumin treatment effectively reduced inflammatory cytokines Tumour Necrosis Factor alpha (TNF-alpha), Interleukin 6 (IL-6), and C-reactive protein (CRP) levels in blood serum.	Curcumin	31-39	C-reactive protein	Rattus norvegicus	181-184
32075287-11	2020	The use of curcumin reduces the subjective perception of the intensity of muscle pain; reduces muscle damage through the decrease of creatine kinase (CK); increases muscle performance; has an anti-inflammatory effect by modulating the pro-inflammatory cytokines, such as TNF-alpha, IL-6, and IL-8; and may have a slight antioxidant effect.	Curcumin	11-19	interleukin 6	Homo sapiens	282-286
32075287-11	2020	The use of curcumin reduces the subjective perception of the intensity of muscle pain; reduces muscle damage through the decrease of creatine kinase (CK); increases muscle performance; has an anti-inflammatory effect by modulating the pro-inflammatory cytokines, such as TNF-alpha, IL-6, and IL-8; and may have a slight antioxidant effect.	Curcumin	11-19	C-X-C motif chemokine ligand 8	Homo sapiens	292-296
32061917-6	2020	RESULTS: CUR and CIP treatment prevented the S. aureus-induced mouse mastitis increase the levels of IL-2, IL-10, and IFN-gamma and decrease levels of IL-6, IL-8, and TNF-alpha.	Curcumin	9-12	interleukin 10	Mus musculus	107-112
32061917-6	2020	RESULTS: CUR and CIP treatment prevented the S. aureus-induced mouse mastitis increase the levels of IL-2, IL-10, and IFN-gamma and decrease levels of IL-6, IL-8, and TNF-alpha.	Curcumin	9-12	interferon gamma	Mus musculus	118-127
32061917-6	2020	RESULTS: CUR and CIP treatment prevented the S. aureus-induced mouse mastitis increase the levels of IL-2, IL-10, and IFN-gamma and decrease levels of IL-6, IL-8, and TNF-alpha.	Curcumin	9-12	interleukin 6	Mus musculus	151-155
32061917-6	2020	RESULTS: CUR and CIP treatment prevented the S. aureus-induced mouse mastitis increase the levels of IL-2, IL-10, and IFN-gamma and decrease levels of IL-6, IL-8, and TNF-alpha.	Curcumin	9-12	tumor necrosis factor	Mus musculus	167-176
32061917-7	2020	Additionally, RT-PCR results showed that 20 mug/mL curcumin inhibited the mRNA expression of TNF-alpha, IL-6, IL-1beta, TRAF6 and MEKK1 in murine mammary epithelial cells (MMECs).	Curcumin	51-59	tumor necrosis factor	Mus musculus	93-102
32061917-7	2020	Additionally, RT-PCR results showed that 20 mug/mL curcumin inhibited the mRNA expression of TNF-alpha, IL-6, IL-1beta, TRAF6 and MEKK1 in murine mammary epithelial cells (MMECs).	Curcumin	51-59	interleukin 6	Mus musculus	104-108
32061917-7	2020	Additionally, RT-PCR results showed that 20 mug/mL curcumin inhibited the mRNA expression of TNF-alpha, IL-6, IL-1beta, TRAF6 and MEKK1 in murine mammary epithelial cells (MMECs).	Curcumin	51-59	TNF receptor-associated factor 6	Mus musculus	120-125
32061917-7	2020	Additionally, RT-PCR results showed that 20 mug/mL curcumin inhibited the mRNA expression of TNF-alpha, IL-6, IL-1beta, TRAF6 and MEKK1 in murine mammary epithelial cells (MMECs).	Curcumin	51-59	mitogen-activated protein kinase kinase kinase 1	Mus musculus	130-135
32061917-8	2020	Likewise, Western blotting results showed that CUR inhibited the expression of TRAF6 and MEKK1.	Curcumin	47-50	TNF receptor-associated factor 6	Mus musculus	79-84
32061917-8	2020	Likewise, Western blotting results showed that CUR inhibited the expression of TRAF6 and MEKK1.	Curcumin	47-50	mitogen-activated protein kinase kinase kinase 1	Mus musculus	89-94
32046055-10	2020	In addition, we found BaP plus curcumin treatment effectively reduced inflammatory cytokines Tumour Necrosis Factor alpha (TNF-alpha), Interleukin 6 (IL-6), and C-reactive protein (CRP) levels in blood serum.	Curcumin	31-39	tumor necrosis factor	Rattus norvegicus	123-132
32046055-10	2020	In addition, we found BaP plus curcumin treatment effectively reduced inflammatory cytokines Tumour Necrosis Factor alpha (TNF-alpha), Interleukin 6 (IL-6), and C-reactive protein (CRP) levels in blood serum.	Curcumin	31-39	interleukin 6	Rattus norvegicus	135-148
32046055-10	2020	In addition, we found BaP plus curcumin treatment effectively reduced inflammatory cytokines Tumour Necrosis Factor alpha (TNF-alpha), Interleukin 6 (IL-6), and C-reactive protein (CRP) levels in blood serum.	Curcumin	31-39	interleukin 6	Rattus norvegicus	150-154
32046055-10	2020	In addition, we found BaP plus curcumin treatment effectively reduced inflammatory cytokines Tumour Necrosis Factor alpha (TNF-alpha), Interleukin 6 (IL-6), and C-reactive protein (CRP) levels in blood serum.	Curcumin	31-39	C-reactive protein	Rattus norvegicus	161-179
32127962-6	2020	Finally, it was demonstrated by reverse transcription-quantitative polymerase chain reaction assay and wound healing assay that curcumin could enhance radiosensitization of NPC cell lines via mediating regulation of tumor stem-like cells by the "hsa_circRNA_102115"-"hsa-miR-335-3p"-"MAPK1" interaction network.	Curcumin	128-136	mitogen-activated protein kinase 1	Homo sapiens	284-289
31776306-9	2020	Moreover, the curcumin operation inhibited the activated of NF-kappaB and level of inflammatory factors like tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	Curcumin	14-22	tumor necrosis factor	Rattus norvegicus	109-136
32175381-12	2020	Pretreatment with curcumin reduced TLR4 and RAGE expression.	Curcumin	18-26	toll-like receptor 4	Rattus norvegicus	35-39
32175381-12	2020	Pretreatment with curcumin reduced TLR4 and RAGE expression.	Curcumin	18-26	advanced glycosylation end product-specific receptor	Rattus norvegicus	44-48
32175381-13	2020	Proinflammatory cytokines such as IL-1beta and TNF-alpha were also remarkably reduced by curcumin.	Curcumin	89-97	interleukin 1 alpha	Rattus norvegicus	34-42
32175381-13	2020	Proinflammatory cytokines such as IL-1beta and TNF-alpha were also remarkably reduced by curcumin.	Curcumin	89-97	tumor necrosis factor	Rattus norvegicus	47-56
32175381-15	2020	Conclusions: Curcumin effectively inhibits Abeta25-35-induced neuroinflammation in microglia, partly by suppressing the expression of HMGB1, TLR4, and RAGE.	Curcumin	13-21	toll-like receptor 4	Rattus norvegicus	141-145
32175381-15	2020	Conclusions: Curcumin effectively inhibits Abeta25-35-induced neuroinflammation in microglia, partly by suppressing the expression of HMGB1, TLR4, and RAGE.	Curcumin	13-21	advanced glycosylation end product-specific receptor	Rattus norvegicus	151-155
32024207-0	2020	Curcumin Protects Human Trophoblast HTR8/SVneo Cells from H2O2-Induced Oxidative Stress by Activating Nrf2 Signaling Pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
32024207-4	2020	Curcumin pre-treatment effectively protected HTR8/SVneo cells against oxidative stress-induced apoptosis via increasing Bcl-2/Bax ratio and decreasing the protein expression level of cleaved-caspase 3.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	120-125
32024207-4	2020	Curcumin pre-treatment effectively protected HTR8/SVneo cells against oxidative stress-induced apoptosis via increasing Bcl-2/Bax ratio and decreasing the protein expression level of cleaved-caspase 3.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	126-129
32024207-6	2020	The antioxidant effect of curcumin was achieved by activating Nrf2 and its downstream antioxidant proteins.	Curcumin	26-34	NFE2 like bZIP transcription factor 2	Homo sapiens	62-66
32024207-7	2020	In addition, knockdown of Nrf2 by Nrf2-siRNA transfection abolished the protective effects of curcumin on HTR8/SVneo cells against oxidative damage.	Curcumin	94-102	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30
32024207-7	2020	In addition, knockdown of Nrf2 by Nrf2-siRNA transfection abolished the protective effects of curcumin on HTR8/SVneo cells against oxidative damage.	Curcumin	94-102	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
32024207-8	2020	Taken together, our results show that curcumin could protect HTR8/SVneo cells from H2O2-induced oxidative stress by activating Nrf2 signaling pathway.	Curcumin	38-46	NFE2 like bZIP transcription factor 2	Homo sapiens	127-131
31776306-8	2020	In addition, curcumin administration increased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and reduced malondialdehyde (MDA).	Curcumin	13-21	glutathione peroxidase 1	Rattus norvegicus	99-105
31776306-8	2020	In addition, curcumin administration increased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and reduced malondialdehyde (MDA).	Curcumin	13-21	catalase	Rattus norvegicus	108-116
31776306-8	2020	In addition, curcumin administration increased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and reduced malondialdehyde (MDA).	Curcumin	13-21	catalase	Rattus norvegicus	118-121
31776306-9	2020	Moreover, the curcumin operation inhibited the activated of NF-kappaB and level of inflammatory factors like tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	Curcumin	14-22	tumor necrosis factor	Rattus norvegicus	138-147
31776306-9	2020	Moreover, the curcumin operation inhibited the activated of NF-kappaB and level of inflammatory factors like tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	Curcumin	14-22	interleukin 1 beta	Rattus norvegicus	150-167
31776306-9	2020	Moreover, the curcumin operation inhibited the activated of NF-kappaB and level of inflammatory factors like tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	Curcumin	14-22	interleukin 1 alpha	Rattus norvegicus	169-177
31776306-9	2020	Moreover, the curcumin operation inhibited the activated of NF-kappaB and level of inflammatory factors like tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	Curcumin	14-22	interleukin 6	Rattus norvegicus	183-196
31776306-9	2020	Moreover, the curcumin operation inhibited the activated of NF-kappaB and level of inflammatory factors like tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	Curcumin	14-22	interleukin 6	Rattus norvegicus	198-202
31773429-10	2020	Curcumin also successfully reduced FcepsilonRI expressions and some pro-inflammatory cytokines, such as interleukin (IL)-4 and IL-13.	Curcumin	0-8	interleukin 13	Homo sapiens	127-132
31816386-6	2020	In this study, we found that curcumin can effectively ameliorate hydrogen peroxide (H2O2)-induced oxidative stress, intestinal epithelial barrier injury and mitochondrial damage in porcine intestinal epithelial cells (IPEC-J2 cells) in a PTEN-induced putative kinase (PINK1)-Parkin mitophagy dependent way.	Curcumin	29-37	PTEN induced kinase 1	Sus scrofa	268-273
31894298-5	2020	Furthermore, to the best of our knowledge, this is the first study to examine the effects of curcumin on Rho-A and on genes involved in EMT, such as Axl, Slug and CD24 in order to determine whether the compound is able to prevent migration and invasion by targeting miRNAs as a regulator of such genes.	Curcumin	93-101	ras homolog family member A	Homo sapiens	105-110
31720988-0	2020	Curcumin Ameliorates Ovalbumin-Induced Atopic Dermatitis and Blocks the Progression of Atopic March in Mice.	Curcumin	0-8	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	21-30
31720988-2	2020	The present work was designed to evaluate the potential of curcumin in amelioration of ovalbumin (OVA) induced AD in mice.	Curcumin	59-67	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	87-96
31877386-0	2020	Quinacrine and curcumin synergistically increased the breast cancer stem cells death by inhibiting ABCG2 and modulating DNA damage repair pathway.	Curcumin	15-23	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	99-104
31894298-8	2020	Curcumin also acted upon the miRNA as a regulator of genes implicated in EMT and upon Rho-A as well, affecting the migration and invasion of the cells.	Curcumin	0-8	ras homolog family member A	Homo sapiens	86-91
31894530-3	2020	In the current study, the role of P2X7 receptor (P2X7R) in the anti-PSD function of Cur was explored.	Curcumin	84-87	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	49-54
32245324-0	2020	In Vitro Effects of Curcumin on Transforming Growth Factor-beta-mediated Non-Smad Signaling Pathway, Oxidative Stress, and Pro-inflammatory Cytokines Production with Human Vascular Smooth Muscle Cells.	Curcumin	20-28	tumor necrosis factor	Homo sapiens	32-63
31793078-7	2020	The results showed that curcumin could regulate the circRNA-miRNA-messenger RNA network and inhibit the epidermal growth factor receptor (EGFR), signal transducers and activators of transcription 3 (STAT3), and growth factor receptor-bound protein 2 (GRB2) to achieve radiosensitization.	Curcumin	24-32	epidermal growth factor receptor	Homo sapiens	104-136
31793078-7	2020	The results showed that curcumin could regulate the circRNA-miRNA-messenger RNA network and inhibit the epidermal growth factor receptor (EGFR), signal transducers and activators of transcription 3 (STAT3), and growth factor receptor-bound protein 2 (GRB2) to achieve radiosensitization.	Curcumin	24-32	epidermal growth factor receptor	Homo sapiens	138-142
31793078-7	2020	The results showed that curcumin could regulate the circRNA-miRNA-messenger RNA network and inhibit the epidermal growth factor receptor (EGFR), signal transducers and activators of transcription 3 (STAT3), and growth factor receptor-bound protein 2 (GRB2) to achieve radiosensitization.	Curcumin	24-32	signal transducer and activator of transcription 3	Homo sapiens	145-197
31793078-7	2020	The results showed that curcumin could regulate the circRNA-miRNA-messenger RNA network and inhibit the epidermal growth factor receptor (EGFR), signal transducers and activators of transcription 3 (STAT3), and growth factor receptor-bound protein 2 (GRB2) to achieve radiosensitization.	Curcumin	24-32	signal transducer and activator of transcription 3	Homo sapiens	199-204
31793078-7	2020	The results showed that curcumin could regulate the circRNA-miRNA-messenger RNA network and inhibit the epidermal growth factor receptor (EGFR), signal transducers and activators of transcription 3 (STAT3), and growth factor receptor-bound protein 2 (GRB2) to achieve radiosensitization.	Curcumin	24-32	growth factor receptor bound protein 2	Homo sapiens	211-249
31793078-7	2020	The results showed that curcumin could regulate the circRNA-miRNA-messenger RNA network and inhibit the epidermal growth factor receptor (EGFR), signal transducers and activators of transcription 3 (STAT3), and growth factor receptor-bound protein 2 (GRB2) to achieve radiosensitization.	Curcumin	24-32	growth factor receptor bound protein 2	Homo sapiens	251-255
32245324-9	2020	Pre-treatment with curcumin, DPI and NAC inhibited TGF-beta-induced IL-6 (p=0.04) and TNF-alpha (p=0.001) mRNA expression, Smad2L phosphorylation (p=0.02) and ROS production (0.03).	Curcumin	19-27	interleukin 6	Homo sapiens	68-72
32245324-9	2020	Pre-treatment with curcumin, DPI and NAC inhibited TGF-beta-induced IL-6 (p=0.04) and TNF-alpha (p=0.001) mRNA expression, Smad2L phosphorylation (p=0.02) and ROS production (0.03).	Curcumin	19-27	tumor necrosis factor	Homo sapiens	86-95
32245324-10	2020	Pharmacological inhibition by Curcumin blocks TGF-beta-induced ROS production, Smad2L phosphorylation, and IL-6 and TNF-alpha mRNA expression in human VSMCs.	Curcumin	30-38	interleukin 6	Homo sapiens	107-111
32245324-10	2020	Pharmacological inhibition by Curcumin blocks TGF-beta-induced ROS production, Smad2L phosphorylation, and IL-6 and TNF-alpha mRNA expression in human VSMCs.	Curcumin	30-38	tumor necrosis factor	Homo sapiens	116-125
31820492-9	2020	Many studies have demonstrated that CUR exhibit strong anticancer, antioxidative stress, and anti-inflammatory activities by regulating signaling pathways, such as nuclear factor erythroid-2-related factor 2, nuclear factor-kappaB, and epigenetics/epigenomics pathways of histones modifications, and DNA methylation.	Curcumin	36-39	NFE2 like bZIP transcription factor 2	Homo sapiens	164-207
31894530-11	2020	The induced activity of P2X7R blocked the function of Cur by maintaining the symptoms of PSD in Cur-treated rats.	Curcumin	54-57	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	24-29
31894530-11	2020	The induced activity of P2X7R blocked the function of Cur by maintaining the symptoms of PSD in Cur-treated rats.	Curcumin	96-99	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	24-29
31894530-12	2020	Collectively, the anti-PSD function of Cur was dependent on the inhibition of P2X7R, which then deactivated Ca2+ channel-mediated inflammatory response associated with PSD progression.	Curcumin	39-42	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	78-83
31656219-6	2020	Curcumin treatment up to 12 and 33 weeks resulted in increased ovarian volume and number of follicles and was associated with elevated anti-Mullerian hormone and oestrogen and diminished FSH serum levels.	Curcumin	0-8	follicle stimulating hormone beta	Mus musculus	187-190
31896509-6	2020	Herein, we observed that ALZ003, a curcumin analog, induces FBXL2-mediated AR ubiquitination, leading to degradation.	Curcumin	35-43	F-box and leucine-rich repeat protein 2	Mus musculus	60-65
32036964-8	2020	OTA decreased liver catalase (CAT) activity in ducks (P &lt; 0.05), while addition of curcumin in OTA group increased liver CAT activity (P &lt; 0.05).	Curcumin	86-94	catalase	Anas platyrhynchos	124-127
32036964-9	2020	16S ribosomal RNA sequencing suggested that curcumin increased the richness indices (ACE index) and diversity indices (Simpson index) compared with OTA group (P &lt; 0.05) and recovered the OTA-induced alterations in composition of the intestinal microbiota.	Curcumin	44-52	angiotensin-converting enzyme	Anas platyrhynchos	85-88
31991669-3	2020	Curcumin (CURC) is a Pgp inhibitor, but it is poorly soluble and bioavailable.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	21-24
32051864-11	2020	In addition, curcumin treatment decreased phosphorylated STAT3 and expression levels of Mcl-1, HDACs and ANGPTL4.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	57-62
31809572-0	2020	Interactions between Curcumin Derivatives and Amyloid-beta Fibrils: Insights from Molecular Dynamics Simulations.	Curcumin	21-29	amyloid beta precursor protein	Homo sapiens	46-58
31809572-2	2020	Previous studies have shown the ability of curcumin to both inhibit the aggregation of Abeta peptides into oligomers or fibrils and reduce amyloids in vivo.	Curcumin	43-51	amyloid beta precursor protein	Homo sapiens	87-92
31809572-3	2020	Despite the promise of curcumin and its derivatives to serve as diagnostic, preventative, and potentially therapeutic AD molecules, the mechanism by which curcumin and its derivatives bind to and inhibit Abeta fibrils" formation remains elusive.	Curcumin	155-163	amyloid beta precursor protein	Homo sapiens	204-209
33329788-8	2020	Results: Curcumin attenuated expression of TNF-alpha, IL-6, and IL-8 and the phosphorylation levels of p38 and JNK, but not ERK1/2, in LPS-stimulated neutrophils.	Curcumin	9-17	tumor necrosis factor	Homo sapiens	43-52
33329788-8	2020	Results: Curcumin attenuated expression of TNF-alpha, IL-6, and IL-8 and the phosphorylation levels of p38 and JNK, but not ERK1/2, in LPS-stimulated neutrophils.	Curcumin	9-17	interleukin 6	Homo sapiens	54-58
33329788-8	2020	Results: Curcumin attenuated expression of TNF-alpha, IL-6, and IL-8 and the phosphorylation levels of p38 and JNK, but not ERK1/2, in LPS-stimulated neutrophils.	Curcumin	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
33329788-8	2020	Results: Curcumin attenuated expression of TNF-alpha, IL-6, and IL-8 and the phosphorylation levels of p38 and JNK, but not ERK1/2, in LPS-stimulated neutrophils.	Curcumin	9-17	mitogen-activated protein kinase 1	Homo sapiens	103-106
33329788-8	2020	Results: Curcumin attenuated expression of TNF-alpha, IL-6, and IL-8 and the phosphorylation levels of p38 and JNK, but not ERK1/2, in LPS-stimulated neutrophils.	Curcumin	9-17	mitogen-activated protein kinase 8	Homo sapiens	111-114
31991669-0	2020	Curcumin-Loaded Solid Lipid Nanoparticles Bypass P-Glycoprotein Mediated Doxorubicin Resistance in Triple Negative Breast Cancer Cells.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	49-63
31991669-0	2020	Curcumin-Loaded Solid Lipid Nanoparticles Bypass P-Glycoprotein Mediated Doxorubicin Resistance in Triple Negative Breast Cancer Cells.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	73-95
31991669-3	2020	Curcumin (CURC) is a Pgp inhibitor, but it is poorly soluble and bioavailable.	Curcumin	10-14	ATP binding cassette subfamily B member 1	Homo sapiens	21-24
31991669-5	2020	Both CURC-loaded SLNs were 5-10-fold more effective than free CURC in increasing the intracellular retention and toxicity of doxorubicin in Pgp-expressing triple negative breast cancer (TNBC).	Curcumin	5-9	ATP binding cassette subfamily B member 1	Homo sapiens	140-143
31991669-8	2020	These results suggest that the combination therapy, based on CURC-loaded SLNs and doxorubicin, is an effective and safe approach to overcome the Pgp-mediated chemoresistance in TNBC.	Curcumin	61-65	ATP binding cassette subfamily B member 1	Homo sapiens	145-148
31803868-0	2020	A fibronectin-coated gold nanostructure composite for electrochemical detection of effects of curcumin-carrying nanoliposomes on human stomach cancer cells.	Curcumin	94-102	fibronectin 1	Homo sapiens	2-13
31974389-4	2020	However, only curcumin is able to influence inflammatory pathways counteracting NF-kappaB activation.	Curcumin	14-22	nuclear factor kappa B subunit 1	Homo sapiens	80-89
31974389-6	2020	Curcumin exerts permissive and chemosensitive properties by targeting the cisplatin chemoresistant factors Nrf-2, NF-kappaB and STAT-3 phosphorylation.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	107-112
31974389-6	2020	Curcumin exerts permissive and chemosensitive properties by targeting the cisplatin chemoresistant factors Nrf-2, NF-kappaB and STAT-3 phosphorylation.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	114-123
31974389-6	2020	Curcumin exerts permissive and chemosensitive properties by targeting the cisplatin chemoresistant factors Nrf-2, NF-kappaB and STAT-3 phosphorylation.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	128-134
31803868-5	2020	According to the electrochemical results, both bare curcumin and curcumin-NLC showed toxicity toward MKN-28 cells in the concentration range of 10-100 muM, which was consistent with the results obtained from a conventional colorimetric method (CCK-8).	Curcumin	52-60	latexin	Homo sapiens	151-154
31803868-5	2020	According to the electrochemical results, both bare curcumin and curcumin-NLC showed toxicity toward MKN-28 cells in the concentration range of 10-100 muM, which was consistent with the results obtained from a conventional colorimetric method (CCK-8).	Curcumin	65-73	latexin	Homo sapiens	151-154
31803868-6	2020	Remarkably, at a low concentration range (&lt;50 muM), this electrochemical platform determined the decrease in cell viability to be approximately 22.8%, 33.9% and 53.1% in the presence of 10, 30, and 50 muM of curcumin-NLC, respectively, compared with the 1.3%, 18.5%, and 28.1% determined by CCK-8, making it 1.7-2 times more sensitive than the conventional colorimetric assay.	Curcumin	211-219	latexin	Homo sapiens	49-52
31803868-6	2020	Remarkably, at a low concentration range (&lt;50 muM), this electrochemical platform determined the decrease in cell viability to be approximately 22.8%, 33.9% and 53.1% in the presence of 10, 30, and 50 muM of curcumin-NLC, respectively, compared with the 1.3%, 18.5%, and 28.1% determined by CCK-8, making it 1.7-2 times more sensitive than the conventional colorimetric assay.	Curcumin	211-219	latexin	Homo sapiens	204-207
32021440-0	2020	Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a.	Curcumin	10-18	carbonic anhydrase 6	Mus musculus	26-29
32021103-0	2020	Curcumin Combined with Thalidomide Reduces Expression of STAT3 and Bcl-xL, Leading to Apoptosis in Acute Myeloid Leukemia Cell Lines.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	57-62
32021103-0	2020	Curcumin Combined with Thalidomide Reduces Expression of STAT3 and Bcl-xL, Leading to Apoptosis in Acute Myeloid Leukemia Cell Lines.	Curcumin	0-8	BCL2 like 1	Homo sapiens	67-73
32021103-9	2020	The expression level of STAT3 and BCL-XL was significantly down-regulated in KG-1 cells after treatment by CUR and THAL and their combination.	Curcumin	107-110	signal transducer and activator of transcription 3	Homo sapiens	24-29
32021103-9	2020	The expression level of STAT3 and BCL-XL was significantly down-regulated in KG-1 cells after treatment by CUR and THAL and their combination.	Curcumin	107-110	BCL2 like 1	Homo sapiens	34-40
32021103-10	2020	Conclusion: Overall, our findings suggested that down-regulation of STAT3 and BCL-XL mRNA expression in response to CUR and THAL treatment lead to inhibition of cell growth and induction of apoptosis.	Curcumin	116-119	signal transducer and activator of transcription 3	Homo sapiens	68-73
32021103-10	2020	Conclusion: Overall, our findings suggested that down-regulation of STAT3 and BCL-XL mRNA expression in response to CUR and THAL treatment lead to inhibition of cell growth and induction of apoptosis.	Curcumin	116-119	BCL2 like 1	Homo sapiens	78-84
32021440-0	2020	Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a.	Curcumin	10-18	thymoma viral proto-oncogene 1	Mus musculus	119-122
32021093-0	2020	Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
32021093-11	2020	Conclusion: Curcumin attenuates oxaliplatin-induced liver injury and oxidative stress by activating the Nrf2 pathway, which suggests that CUR may be potentially used in the prevention and treatment of OXA-induced liver injury.	Curcumin	12-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-108
31921358-0	2020	Curcumin analog A13 alleviates oxidative stress by activating Nrf2/ARE pathway and ameliorates fibrosis in the myocardium of high-fat-diet and streptozotocin-induced diabetic rats.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	62-66
31936675-0	2020	Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	123-128
31936675-2	2020	Hence, we investigated whether curcumin, a natural compound, can target the JAK/STAT3 signaling pathway to induce cytotoxic effects in papillary thyroid cancer (PTC) cell lines (BCPAP and TPC-1) and derived thyroid cancer stem-like cells (thyrospheres).	Curcumin	31-39	signal transducer and activator of transcription 3	Homo sapiens	80-85
31936675-2	2020	Hence, we investigated whether curcumin, a natural compound, can target the JAK/STAT3 signaling pathway to induce cytotoxic effects in papillary thyroid cancer (PTC) cell lines (BCPAP and TPC-1) and derived thyroid cancer stem-like cells (thyrospheres).	Curcumin	31-39	two pore segment channel 1	Homo sapiens	188-193
31936675-3	2020	Curcumin suppressed PTC cell survival in a dose-dependent manner via the induction of caspase-mediated apoptosis and caused the attenuation of constitutively active STAT3 (the dephosphorylation of Tyr705-STAT3) without affecting STAT3.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	165-170
31936675-3	2020	Curcumin suppressed PTC cell survival in a dose-dependent manner via the induction of caspase-mediated apoptosis and caused the attenuation of constitutively active STAT3 (the dephosphorylation of Tyr705-STAT3) without affecting STAT3.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	197-209
31936675-3	2020	Curcumin suppressed PTC cell survival in a dose-dependent manner via the induction of caspase-mediated apoptosis and caused the attenuation of constitutively active STAT3 (the dephosphorylation of Tyr705-STAT3) without affecting STAT3.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	204-209
31936675-5	2020	The cotreatment of PTC cell lines with curcumin and cisplatin synergistically potentiated cytotoxic effects via the suppression of JAK/STAT3 activity along with the inhibition of antiapoptotic genes and the induction of proapoptotic genes, and it also suppressed the migration of PTC cells by downregulating matrix metalloproteinases and the inhibition of colony formation.	Curcumin	39-47	signal transducer and activator of transcription 3	Homo sapiens	135-140
31936675-6	2020	Finally, thyrospheres treated with curcumin and cisplatin showed suppressed STAT3 phosphorylation, a reduced formation of thyrospheres, and the downregulated expression of stemness markers, in addition to apoptosis.	Curcumin	35-43	signal transducer and activator of transcription 3	Homo sapiens	76-81
31936675-7	2020	The current study"s findings suggest that curcumin synergistically enhances the anticancer activity of cisplatin in PTC cells as well as in cancer stem-like cells by targeting STAT3, which suggests that curcumin combined with chemotherapeutic agents may provide better therapeutic outcomes.	Curcumin	42-50	signal transducer and activator of transcription 3	Homo sapiens	176-181
31936675-7	2020	The current study"s findings suggest that curcumin synergistically enhances the anticancer activity of cisplatin in PTC cells as well as in cancer stem-like cells by targeting STAT3, which suggests that curcumin combined with chemotherapeutic agents may provide better therapeutic outcomes.	Curcumin	203-211	signal transducer and activator of transcription 3	Homo sapiens	176-181
31921358-13	2020	Conclusion: Treatment with curcumin analog A13 protects the morphology of myocardium, restores the MDA levels and SOD activity, activates the Nrf2/ARE pathway and ameliorates myocardial fibrosis in diabetic rats.	Curcumin	27-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	142-146
31628941-0	2020	Inhibition of aldehyde dehydrogenase-1 and p-glycoprotein-mediated multidrug resistance by curcumin and vitamin D3 increases sensitivity to paclitaxel in breast cancer.	Curcumin	91-99	ATP binding cassette subfamily B member 1	Homo sapiens	43-57
31628941-4	2020	The present study, therefore, aimed at investigating the effect of both curcumin (CUR) and vitamin D3 (D3) on MDR-1 and ALDH-1 expression and consequently the resistance to PAX both in vitro and in vivo.	Curcumin	72-80	ATP binding cassette subfamily B member 1	Homo sapiens	110-115
31628941-4	2020	The present study, therefore, aimed at investigating the effect of both curcumin (CUR) and vitamin D3 (D3) on MDR-1 and ALDH-1 expression and consequently the resistance to PAX both in vitro and in vivo.	Curcumin	82-85	ATP binding cassette subfamily B member 1	Homo sapiens	110-115
31799835-8	2020	Although the induction of heme oxygenase-1, an antioxidant response element-regulated gene product, was much stronger in curcumin-treated cells than in GIF-2165X-G1-treated cells, it turned out that the induction of heme oxygenase-1 is dispensable for neuroprotection.	Curcumin	121-129	heme oxygenase 1	Mus musculus	26-42
31947962-5	2020	Local intravaginal delivery of curcumin nanoparticles, but not intraperitoneal or oral delivery, reduced CpG-mediated inflammatory histopathology and decreased production of pro-inflammatory cytokines Interleukin (IL)-6, Tumor Necrosis Factor Alpha (TNF-alpha) and Monocyte Chemoattractant Protein-1 (MCP-1) in the FGT.	Curcumin	31-39	interleukin 6	Homo sapiens	201-219
31947962-5	2020	Local intravaginal delivery of curcumin nanoparticles, but not intraperitoneal or oral delivery, reduced CpG-mediated inflammatory histopathology and decreased production of pro-inflammatory cytokines Interleukin (IL)-6, Tumor Necrosis Factor Alpha (TNF-alpha) and Monocyte Chemoattractant Protein-1 (MCP-1) in the FGT.	Curcumin	31-39	tumor necrosis factor	Homo sapiens	221-248
31947962-5	2020	Local intravaginal delivery of curcumin nanoparticles, but not intraperitoneal or oral delivery, reduced CpG-mediated inflammatory histopathology and decreased production of pro-inflammatory cytokines Interleukin (IL)-6, Tumor Necrosis Factor Alpha (TNF-alpha) and Monocyte Chemoattractant Protein-1 (MCP-1) in the FGT.	Curcumin	31-39	tumor necrosis factor	Homo sapiens	250-259
31799835-8	2020	Although the induction of heme oxygenase-1, an antioxidant response element-regulated gene product, was much stronger in curcumin-treated cells than in GIF-2165X-G1-treated cells, it turned out that the induction of heme oxygenase-1 is dispensable for neuroprotection.	Curcumin	121-129	heme oxygenase 1	Mus musculus	216-232
32673649-12	2020	On the other hand, curcumin decreased JNK and Smad3 phosphorylation.	Curcumin	19-27	SMAD family member 3	Rattus norvegicus	46-51
32673649-13	2020	Furthermore, curcumin treatment decreased alpha-SMA and Smad3 protein and mRNA levels.	Curcumin	13-21	SMAD family member 3	Rattus norvegicus	56-61
32673649-0	2020	Curcumin downregulates Smad pathways and reduces hepatic stellate cells activation in experimental fibrosis.	Curcumin	0-8	SMAD family member 7	Rattus norvegicus	23-27
32673649-14	2020	Curcumin normalized GSH, and NF-kappaB, JNK-Smad3, and TGF-beta-Smad3 pathways, leading to a decrement in activated hepatic stellate cells, thereby producing its antifibrotic effects.	Curcumin	0-8	SMAD family member 3	Rattus norvegicus	44-49
32673649-14	2020	Curcumin normalized GSH, and NF-kappaB, JNK-Smad3, and TGF-beta-Smad3 pathways, leading to a decrement in activated hepatic stellate cells, thereby producing its antifibrotic effects.	Curcumin	0-8	SMAD family member 3	Rattus norvegicus	64-69
32673649-11	2020	Besides, curcumin restored NF-kappaB, IL-1, IL-10, TGF-beta, CTGF, Col-I, MMP-13, and Smad7 protein levels.	Curcumin	9-17	SMAD family member 7	Rattus norvegicus	86-91
30332967-1	2020	INTRODUCTION: The primary aim of this study is to understand the binding of curcumin and its analogues to different PDE4 subtypes and identification of the role of PDE4 subtype inhibition in the anti-inflammatory property of curcumin.	Curcumin	76-84	phosphodiesterase 4A	Homo sapiens	116-120
31232084-5	2020	It is put forward that some nutrients such as dairy products, curcumin, niacin, palmitate, coffee and alcohol consumption decrease fetuin-A level, and dietary omega-3 fatty acids intake may increase fetuin-A concentration.	Curcumin	62-70	alpha 2-HS glycoprotein	Homo sapiens	131-139
32067622-0	2020	Metalloproteinases Suppression Driven by the Curcumin Analog DM-1 Modulates Invasion in BRAF-Resistant Melanomas.	Curcumin	45-53	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	88-92
31902919-0	2020	The Synthetic Curcumin Derivative CNB-001 Attenuates Thrombin-Stimulated Microglial Inflammation by Inhibiting the ERK and p38 MAPK Pathways.	Curcumin	14-22	coagulation factor II	Rattus norvegicus	53-61
31902919-0	2020	The Synthetic Curcumin Derivative CNB-001 Attenuates Thrombin-Stimulated Microglial Inflammation by Inhibiting the ERK and p38 MAPK Pathways.	Curcumin	14-22	Eph receptor B1	Rattus norvegicus	115-118
32417759-11	2020	In conclusion, Cur inhibits proliferation of hepatocellular carcinoma cells and PTEN/PI3K/AKT signaling pathway via the reduction of DJ-1 expression, which provides new insights to the anticancer effects of curcumin in hepatocellular carcinoma.	Curcumin	207-215	AKT serine/threonine kinase 1	Homo sapiens	90-93
30332967-1	2020	INTRODUCTION: The primary aim of this study is to understand the binding of curcumin and its analogues to different PDE4 subtypes and identification of the role of PDE4 subtype inhibition in the anti-inflammatory property of curcumin.	Curcumin	225-233	phosphodiesterase 4A	Homo sapiens	164-168
30332967-3	2020	MATERIALS AND METHOD: Curcumin and its analogues were subjected to docking using PDE4A, PDE4B, PDE4C and PDE4D as the target.	Curcumin	22-30	phosphodiesterase 4A	Homo sapiens	81-86
30332967-3	2020	MATERIALS AND METHOD: Curcumin and its analogues were subjected to docking using PDE4A, PDE4B, PDE4C and PDE4D as the target.	Curcumin	22-30	phosphodiesterase 4B	Homo sapiens	88-93
30332967-3	2020	MATERIALS AND METHOD: Curcumin and its analogues were subjected to docking using PDE4A, PDE4B, PDE4C and PDE4D as the target.	Curcumin	22-30	phosphodiesterase 4C	Homo sapiens	95-100
30332967-4	2020	A data set comprising of 18 analogues of curcumin was used as ligands for docking of PDE4 subtypes.	Curcumin	41-49	phosphodiesterase 4A	Homo sapiens	85-89
30332967-9	2020	Key Finding: All curcumin analogues used in the study showed good binding affinity with all PDE4 subtypes, with evident selectivity towards PDE4B subtype.	Curcumin	17-25	phosphodiesterase 4A	Homo sapiens	92-96
30332967-9	2020	Key Finding: All curcumin analogues used in the study showed good binding affinity with all PDE4 subtypes, with evident selectivity towards PDE4B subtype.	Curcumin	17-25	phosphodiesterase 4B	Homo sapiens	140-145
30332967-11	2020	CONCLUSIONS: Curcumin and analogues have moderate to strong affinity towards all PDE4 subtypes and have evident selectivity towards PDE4B.	Curcumin	13-21	phosphodiesterase 4A	Homo sapiens	81-85
30332967-11	2020	CONCLUSIONS: Curcumin and analogues have moderate to strong affinity towards all PDE4 subtypes and have evident selectivity towards PDE4B.	Curcumin	13-21	phosphodiesterase 4B	Homo sapiens	132-137
32338209-9	2020	Curcumin, a natural anti-inflammatory agent, which is capable of stimulating the synthesis of endogenous IAP, represents another alternative approach in the treatment of IBD.	Curcumin	0-8	alkaline phosphatase, intestinal	Homo sapiens	105-108
31991296-2	2020	The aim in this trial was to evaluate the efficacy of curcumin supplementation on oxidative stress enzymes, sirtuin-1 (SIRT1) and Peroxisome proliferator activated receptor gamma coactivator 1alpha (PGC1alpha) gene expression in PCOS patients.	Curcumin	54-62	PPARG coactivator 1 alpha	Homo sapiens	130-197
31991296-2	2020	The aim in this trial was to evaluate the efficacy of curcumin supplementation on oxidative stress enzymes, sirtuin-1 (SIRT1) and Peroxisome proliferator activated receptor gamma coactivator 1alpha (PGC1alpha) gene expression in PCOS patients.	Curcumin	54-62	PPARG coactivator 1 alpha	Homo sapiens	199-208
31991296-7	2020	Curcumin supplementation significantly increased gene expression of PGC1alpha (p = 0.011) and activity of the Gpx enzyme (p = 0.045).	Curcumin	0-8	PPARG coactivator 1 alpha	Homo sapiens	68-77
33016914-4	2020	METHODS: We conducted a literature review in PubMed, screening all articles published before July 7, 2019 related to TNF blocking agents and curcumin (another TNF-alpha inhibitor) in the context of AD pathology.	Curcumin	141-149	tumor necrosis factor	Homo sapiens	159-168
32156842-0	2020	The Effects of Nano-curcumin Supplementation on Serum Level of hs-CRP, Adhesion Molecules, and Lipid Profiles in Hemodialysis Patients, A Randomized Controlled Clinical Trial.	Curcumin	20-28	C-reactive protein	Homo sapiens	66-69
32156842-4	2020	RESULTS: The results revealed that the mean serum hs-CRP level in the nano-curcumin group exhibited a decrease by the end of the study, when compared to mean serum hs-CRP level in the placebo group.	Curcumin	75-83	C-reactive protein	Homo sapiens	53-56
32156842-4	2020	RESULTS: The results revealed that the mean serum hs-CRP level in the nano-curcumin group exhibited a decrease by the end of the study, when compared to mean serum hs-CRP level in the placebo group.	Curcumin	75-83	C-reactive protein	Homo sapiens	167-170
32348213-4	2020	OBJECTIVE: To evaluate the effect of curcumin nanoemulsions prepared with lecithin modified with medium-chain fatty acids as an emulsifier, on the expression of the Cdk4, Ccne2, Casp8 and Cldn4 genes involved in the carcinogenesis process in K14E6 transgenic mice.	Curcumin	37-45	cyclin-dependent kinase 4	Mus musculus	165-169
31812069-0	2020	Curcumin ameliorates hepatic chronic inflammation induced by bile duct obstruction in mice through the activation of heme oxygenase-1.	Curcumin	0-8	heme oxygenase 1	Mus musculus	117-133
32156842-7	2020	Based on the attained results, mean serum levels of VCAM-1 in the nano-curcumin group were significantly reduced at the end of the study, compared with the placebo group (P < .001).	Curcumin	71-79	vascular cell adhesion molecule 1	Homo sapiens	52-58
33016914-9	2020	A small human RCT using Theracurmin, a well-absorbed form of curcumin that lowers TNF-alpha, showed enhanced cognitive performance and decreased brain levels of amyloid-beta plaque and tau tangles.	Curcumin	61-69	tumor necrosis factor	Homo sapiens	82-91
33016914-9	2020	A small human RCT using Theracurmin, a well-absorbed form of curcumin that lowers TNF-alpha, showed enhanced cognitive performance and decreased brain levels of amyloid-beta plaque and tau tangles.	Curcumin	61-69	amyloid beta precursor protein	Homo sapiens	161-173
31845532-6	2020	Furthermore, studies aimed to identify the potential molecular and cellular mechanisms revealed that this protective effect of curcumin on osteoclastogenesis occurred through the amelioration of the activation of Akt/NF-kappaB/NFATc1 pathways.	Curcumin	127-135	thymoma viral proto-oncogene 1	Mus musculus	213-216
32277661-9	2020	Further, it was observed that the anticancer effects of piperine and curcumin were due to the induction of mitochondrial-mediated apoptosis which was also associated with enhancement of the Bax expression.	Curcumin	69-77	BCL2 associated X, apoptosis regulator	Homo sapiens	190-193
31845532-6	2020	Furthermore, studies aimed to identify the potential molecular and cellular mechanisms revealed that this protective effect of curcumin on osteoclastogenesis occurred through the amelioration of the activation of Akt/NF-kappaB/NFATc1 pathways.	Curcumin	127-135	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	217-226
31845532-6	2020	Furthermore, studies aimed to identify the potential molecular and cellular mechanisms revealed that this protective effect of curcumin on osteoclastogenesis occurred through the amelioration of the activation of Akt/NF-kappaB/NFATc1 pathways.	Curcumin	127-135	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	227-233
31587004-0	2020	Cytochrome P450-Mediated Metabolic Characterization of a Mono-Carbonyl Curcumin Analog WZ35.	Curcumin	57-79	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-15
31595422-7	2020	Our results show that curcumin inhibits BACE1 gene expression in SH-SY5Y cells at transcriptional and translational levels.	Curcumin	22-30	beta-secretase 1	Homo sapiens	40-45
31595422-8	2020	Furthermore, we reveal that nuclear factor kappa B (NFkappaB) signaling is involved in the regulation of curcumin on BACE1.	Curcumin	105-113	nuclear factor kappa B subunit 1	Homo sapiens	28-50
31595422-8	2020	Furthermore, we reveal that nuclear factor kappa B (NFkappaB) signaling is involved in the regulation of curcumin on BACE1.	Curcumin	105-113	nuclear factor kappa B subunit 1	Homo sapiens	52-60
31595422-8	2020	Furthermore, we reveal that nuclear factor kappa B (NFkappaB) signaling is involved in the regulation of curcumin on BACE1.	Curcumin	105-113	beta-secretase 1	Homo sapiens	117-122
31595422-10	2020	Our data show that curcumin activates estrogen receptor beta (ERbeta) selectively and the activation of ERbeta directly effects on the upstream factors of the NFkappaB signaling pathway.	Curcumin	19-27	estrogen receptor 1	Homo sapiens	38-60
31595422-10	2020	Our data show that curcumin activates estrogen receptor beta (ERbeta) selectively and the activation of ERbeta directly effects on the upstream factors of the NFkappaB signaling pathway.	Curcumin	19-27	estrogen receptor 1	Homo sapiens	62-68
31595422-10	2020	Our data show that curcumin activates estrogen receptor beta (ERbeta) selectively and the activation of ERbeta directly effects on the upstream factors of the NFkappaB signaling pathway.	Curcumin	19-27	nuclear factor kappa B subunit 1	Homo sapiens	159-167
31595422-11	2020	The above results indicate that curcumin reduces BACE1 expression through ERbeta and NFkappaB pathway, providing a novel mechanism for curcumin as a candidate for AD therapy.	Curcumin	32-40	beta-secretase 1	Homo sapiens	49-54
31595422-11	2020	The above results indicate that curcumin reduces BACE1 expression through ERbeta and NFkappaB pathway, providing a novel mechanism for curcumin as a candidate for AD therapy.	Curcumin	32-40	estrogen receptor 1	Homo sapiens	74-80
31595422-11	2020	The above results indicate that curcumin reduces BACE1 expression through ERbeta and NFkappaB pathway, providing a novel mechanism for curcumin as a candidate for AD therapy.	Curcumin	32-40	nuclear factor kappa B subunit 1	Homo sapiens	85-93
31595422-11	2020	The above results indicate that curcumin reduces BACE1 expression through ERbeta and NFkappaB pathway, providing a novel mechanism for curcumin as a candidate for AD therapy.	Curcumin	135-143	beta-secretase 1	Homo sapiens	49-54
31595422-11	2020	The above results indicate that curcumin reduces BACE1 expression through ERbeta and NFkappaB pathway, providing a novel mechanism for curcumin as a candidate for AD therapy.	Curcumin	135-143	estrogen receptor 1	Homo sapiens	74-80
31595422-11	2020	The above results indicate that curcumin reduces BACE1 expression through ERbeta and NFkappaB pathway, providing a novel mechanism for curcumin as a candidate for AD therapy.	Curcumin	135-143	nuclear factor kappa B subunit 1	Homo sapiens	85-93
32821730-8	2020	This inhibition by curcumin results in the abolition of phosphorylation of protein kinase C, p38 mitogen-activated protein kinase, and cAMP response element-binding protein.	Curcumin	19-27	mitogen-activated protein kinase 14	Homo sapiens	93-129
31595422-0	2020	Curcumin inhibits BACE1 expression through the interaction between ERbeta and NFkappaB signaling pathway in SH-SY5Y cells.	Curcumin	0-8	beta-secretase 1	Homo sapiens	18-23
31595422-0	2020	Curcumin inhibits BACE1 expression through the interaction between ERbeta and NFkappaB signaling pathway in SH-SY5Y cells.	Curcumin	0-8	estrogen receptor 1	Homo sapiens	67-73
31595422-0	2020	Curcumin inhibits BACE1 expression through the interaction between ERbeta and NFkappaB signaling pathway in SH-SY5Y cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	78-86
31595422-6	2020	In the present study, we find that curcumin markedly reduces Abeta levels in HEK293-APPswe cells.	Curcumin	35-43	amyloid beta precursor protein	Homo sapiens	61-66
31897118-0	2020	Curcumin increases the sensitivity of K562/DOX cells to doxorubicin by targeting S100 calcium-binding protein A8 and P-glycoprotein.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	117-131
31897118-6	2020	Western blot analysis revealed that curcumin treatment caused a downregulation of the expression of P-glycoprotein (P-gp) and S100A8 in a dose- and time-dependent manner.	Curcumin	36-44	ATP binding cassette subfamily B member 1	Homo sapiens	100-114
31897118-6	2020	Western blot analysis revealed that curcumin treatment caused a downregulation of the expression of P-glycoprotein (P-gp) and S100A8 in a dose- and time-dependent manner.	Curcumin	36-44	ATP binding cassette subfamily B member 1	Homo sapiens	116-120
31897118-10	2020	In conclusion, the present study suggested that inhibition of S100A8 expression increased DOX-induced apoptosis, and curcumin acted independently on S100A8 and P-gp to exert its drug resistance reversal effects.	Curcumin	117-125	ATP binding cassette subfamily B member 1	Homo sapiens	160-164
31526948-8	2020	Finally, we demonstrated that in pancreatic epithelioid carcinoma cells (PANC1) that are knockout for NQO1, the reestablishment of NQO1 expression can stabilize p53 in presence of curcumin.	Curcumin	180-188	NAD(P)H quinone dehydrogenase 1	Homo sapiens	102-106
31526948-8	2020	Finally, we demonstrated that in pancreatic epithelioid carcinoma cells (PANC1) that are knockout for NQO1, the reestablishment of NQO1 expression can stabilize p53 in presence of curcumin.	Curcumin	180-188	NAD(P)H quinone dehydrogenase 1	Homo sapiens	131-135
31526948-0	2020	Curcumin stabilizes p53 by interaction with NAD(P)H:quinone oxidoreductase 1 in tumor-derived cell lines.	Curcumin	0-8	tumor protein p53	Homo sapiens	20-23
31526948-9	2020	Collectively, our findings showed that curcumin is necessary to promote the protein interaction of NQO1 with p53, therefore, it increases the half-life of p53, and permits the cytotoxic effect of curcumin in cancer cells containing wild type p53.	Curcumin	39-47	NAD(P)H quinone dehydrogenase 1	Homo sapiens	99-103
31526948-0	2020	Curcumin stabilizes p53 by interaction with NAD(P)H:quinone oxidoreductase 1 in tumor-derived cell lines.	Curcumin	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	44-76
31526948-1	2020	Curcumin is a natural phytochemical with potent anti-neoplastic properties including modulation of p53.	Curcumin	0-8	tumor protein p53	Homo sapiens	99-102
31526948-9	2020	Collectively, our findings showed that curcumin is necessary to promote the protein interaction of NQO1 with p53, therefore, it increases the half-life of p53, and permits the cytotoxic effect of curcumin in cancer cells containing wild type p53.	Curcumin	39-47	tumor protein p53	Homo sapiens	109-112
31526948-3	2020	The purpose of this study was to describe a mechanism by which curcumin restores p53 levels in human cancer cell lines.	Curcumin	63-71	tumor protein p53	Homo sapiens	81-84
31526948-9	2020	Collectively, our findings showed that curcumin is necessary to promote the protein interaction of NQO1 with p53, therefore, it increases the half-life of p53, and permits the cytotoxic effect of curcumin in cancer cells containing wild type p53.	Curcumin	39-47	tumor protein p53	Homo sapiens	155-158
31526948-5	2020	Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin.	Curcumin	20-28	tumor protein p53	Homo sapiens	56-59
31526948-5	2020	Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin.	Curcumin	20-28	tumor protein p53	Homo sapiens	94-97
31526948-9	2020	Collectively, our findings showed that curcumin is necessary to promote the protein interaction of NQO1 with p53, therefore, it increases the half-life of p53, and permits the cytotoxic effect of curcumin in cancer cells containing wild type p53.	Curcumin	39-47	tumor protein p53	Homo sapiens	155-158
31526948-5	2020	Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin.	Curcumin	20-28	NAD(P)H quinone dehydrogenase 1	Homo sapiens	98-102
31526948-5	2020	Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin.	Curcumin	20-28	tumor protein p53	Homo sapiens	94-97
31526948-9	2020	Collectively, our findings showed that curcumin is necessary to promote the protein interaction of NQO1 with p53, therefore, it increases the half-life of p53, and permits the cytotoxic effect of curcumin in cancer cells containing wild type p53.	Curcumin	196-204	NAD(P)H quinone dehydrogenase 1	Homo sapiens	99-103
31526948-5	2020	Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin.	Curcumin	20-28	NAD(P)H quinone dehydrogenase 1	Homo sapiens	110-142
31526948-5	2020	Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin.	Curcumin	174-182	tumor protein p53	Homo sapiens	56-59
31526948-9	2020	Collectively, our findings showed that curcumin is necessary to promote the protein interaction of NQO1 with p53, therefore, it increases the half-life of p53, and permits the cytotoxic effect of curcumin in cancer cells containing wild type p53.	Curcumin	196-204	tumor protein p53	Homo sapiens	109-112
31526948-5	2020	Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin.	Curcumin	174-182	tumor protein p53	Homo sapiens	94-97
31526948-10	2020	Our findings suggest that the use of curcumin may reactivate the p53 pathway in cancer cells with p53 wild-type.	Curcumin	37-45	tumor protein p53	Homo sapiens	65-68
31526948-5	2020	Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin.	Curcumin	174-182	NAD(P)H quinone dehydrogenase 1	Homo sapiens	98-102
31526948-5	2020	Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin.	Curcumin	174-182	tumor protein p53	Homo sapiens	94-97
31526948-5	2020	Here we showed that curcumin increases the half-life of p53 by a physical interaction between p53-NQO1 (p53 - NAD(P)H:quinone oxidoreductase 1) proteins after treatment with curcumin.	Curcumin	174-182	NAD(P)H quinone dehydrogenase 1	Homo sapiens	110-142
31526948-6	2020	Interestingly, the cell viability assay after treatment with curcumin showed that the cytotoxic activity was selectively higher in cervical cancer cells contained wild type p53 but not in breast cancer cells contained mutated p53.	Curcumin	61-69	tumor protein p53	Homo sapiens	173-176
31526948-10	2020	Our findings suggest that the use of curcumin may reactivate the p53 pathway in cancer cells with p53 wild-type.	Curcumin	37-45	tumor protein p53	Homo sapiens	98-101
31841506-0	2019	Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments.	Curcumin	51-59	AKT serine/threonine kinase 1	Homo sapiens	110-113
31526948-6	2020	Interestingly, the cell viability assay after treatment with curcumin showed that the cytotoxic activity was selectively higher in cervical cancer cells contained wild type p53 but not in breast cancer cells contained mutated p53.	Curcumin	61-69	tumor protein p53	Homo sapiens	226-229
31526948-7	2020	The cytotoxic effect of curcumin in cervical cancer cells was related to the complex p53-NQO1 that avoids the interaction between p53 and its negative regulator ubiquitin ligase E6-associated protein (E6AP).	Curcumin	24-32	tumor protein p53	Homo sapiens	85-88
31526948-7	2020	The cytotoxic effect of curcumin in cervical cancer cells was related to the complex p53-NQO1 that avoids the interaction between p53 and its negative regulator ubiquitin ligase E6-associated protein (E6AP).	Curcumin	24-32	NAD(P)H quinone dehydrogenase 1	Homo sapiens	89-93
31526948-7	2020	The cytotoxic effect of curcumin in cervical cancer cells was related to the complex p53-NQO1 that avoids the interaction between p53 and its negative regulator ubiquitin ligase E6-associated protein (E6AP).	Curcumin	24-32	tumor protein p53	Homo sapiens	130-133
33124505-0	2020	Curcumin Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer Cells Through Radiation-Induced Suppression of Epithelial-Mesenchymal Transition and Soluble E-Cadherin Expression.	Curcumin	0-8	cadherin 1	Homo sapiens	168-178
31878265-7	2019	Dietary supplementation with 200 mg/kg curcumin significantly reduced cysteinyl aspartate specific proteinase 3 (caspase3), BCL2-associated X protein (bax), B-cellCLL/lymphoma 2 (bcl2), and heat-shock protein 70 (hsp70) mRNA expression, and increased occludin (ocln) mRNA expression (p &lt; 0.05).	Curcumin	39-47	heat shock 70 kDa protein 6	Sus scrofa	190-211
31878265-7	2019	Dietary supplementation with 200 mg/kg curcumin significantly reduced cysteinyl aspartate specific proteinase 3 (caspase3), BCL2-associated X protein (bax), B-cellCLL/lymphoma 2 (bcl2), and heat-shock protein 70 (hsp70) mRNA expression, and increased occludin (ocln) mRNA expression (p &lt; 0.05).	Curcumin	39-47	heat shock 70 kDa protein 6	Sus scrofa	213-218
32360040-0	2020	Curcumin Attenuates Hemorrhagic Shock and Blood Replenish Resuscitation-induced Impairment of Pulmonary Barrier Function by Increasing SIRT1 and Reducing Malondialdehyde and TNF-alpha Contents and Neutrophil Infiltration in Lung in a Dose-Dependent Fashion.	Curcumin	0-8	sirtuin 1	Rattus norvegicus	135-140
32360040-0	2020	Curcumin Attenuates Hemorrhagic Shock and Blood Replenish Resuscitation-induced Impairment of Pulmonary Barrier Function by Increasing SIRT1 and Reducing Malondialdehyde and TNF-alpha Contents and Neutrophil Infiltration in Lung in a Dose-Dependent Fashion.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	174-183
32360040-3	2020	Curcumin is a potent activator of SIRT1 and possesses antioxidative and anti-inflammatory effects.	Curcumin	0-8	sirtuin 1	Rattus norvegicus	34-39
32360040-11	2020	Curcumin pretreatment demonstrated lung protection efficacy with improved pulmonary barrier function, increased lung SIRT1, and reduced pulmonary oxidative stress and lung inflammation in a dose-dependent fashion.	Curcumin	0-8	sirtuin 1	Rattus norvegicus	117-122
32360040-12	2020	CONCLUSIONS: Curcumin pretreatment protects against HSR-induced pulmonary function impairment by increasing tissue SIRT1, which reduced lavage MDA and TNF-alpha and differential neutrophil count in a dose-dependent fashion.	Curcumin	13-21	sirtuin 1	Rattus norvegicus	115-120
32360040-12	2020	CONCLUSIONS: Curcumin pretreatment protects against HSR-induced pulmonary function impairment by increasing tissue SIRT1, which reduced lavage MDA and TNF-alpha and differential neutrophil count in a dose-dependent fashion.	Curcumin	13-21	tumor necrosis factor	Rattus norvegicus	151-160
31976028-5	2019	CUR treatment induced autophagy and enhanced autophagic flux in an AMPK/mTOR/ULK1-dependent manner.	Curcumin	0-3	mechanistic target of rapamycin kinase	Homo sapiens	72-76
31862869-0	2019	Curcumin Alleviates Lipopolysaccharide (LPS)-Activated Neuroinflammation via Modulation of miR-199b-5p/IkappaB Kinase beta (IKKbeta)/Nuclear Factor Kappa B (NF-kappaB) Pathway in Microglia.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	133-155
31862869-0	2019	Curcumin Alleviates Lipopolysaccharide (LPS)-Activated Neuroinflammation via Modulation of miR-199b-5p/IkappaB Kinase beta (IKKbeta)/Nuclear Factor Kappa B (NF-kappaB) Pathway in Microglia.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	157-166
31862869-7	2019	RESULTS Curcumin significantly suppressed inflammatory response induced by LPS by inactivation of nuclear factor kappa B (NF-kappaB) in microglial cells, as reflected by the decreased levels of p-p65, as well as the pro-inflammatory mediators, including inducible nitric oxide synthase (iNOS), TNF-alpha, and IL-1ss.	Curcumin	8-16	nuclear factor kappa B subunit 1	Homo sapiens	98-120
31862869-7	2019	RESULTS Curcumin significantly suppressed inflammatory response induced by LPS by inactivation of nuclear factor kappa B (NF-kappaB) in microglial cells, as reflected by the decreased levels of p-p65, as well as the pro-inflammatory mediators, including inducible nitric oxide synthase (iNOS), TNF-alpha, and IL-1ss.	Curcumin	8-16	nuclear factor kappa B subunit 1	Homo sapiens	122-131
31862869-7	2019	RESULTS Curcumin significantly suppressed inflammatory response induced by LPS by inactivation of nuclear factor kappa B (NF-kappaB) in microglial cells, as reflected by the decreased levels of p-p65, as well as the pro-inflammatory mediators, including inducible nitric oxide synthase (iNOS), TNF-alpha, and IL-1ss.	Curcumin	8-16	nitric oxide synthase 2	Homo sapiens	254-285
31862869-7	2019	RESULTS Curcumin significantly suppressed inflammatory response induced by LPS by inactivation of nuclear factor kappa B (NF-kappaB) in microglial cells, as reflected by the decreased levels of p-p65, as well as the pro-inflammatory mediators, including inducible nitric oxide synthase (iNOS), TNF-alpha, and IL-1ss.	Curcumin	8-16	nitric oxide synthase 2	Homo sapiens	287-291
31862869-7	2019	RESULTS Curcumin significantly suppressed inflammatory response induced by LPS by inactivation of nuclear factor kappa B (NF-kappaB) in microglial cells, as reflected by the decreased levels of p-p65, as well as the pro-inflammatory mediators, including inducible nitric oxide synthase (iNOS), TNF-alpha, and IL-1ss.	Curcumin	8-16	tumor necrosis factor	Homo sapiens	294-303
31862869-9	2019	Knockdown of miR-199b-5p or overexpression of IKKss reversed the inhibitory effect of curcumin on inflammatory response and NF-kappaB activation.	Curcumin	86-94	nuclear factor kappa B subunit 1	Homo sapiens	124-133
31862869-12	2019	CONCLUSIONS Curcumin attenuated neuroinflammation induced by LPS through regulating miR-199b-5p/IKKss/NF-kappaB axis in microglia.	Curcumin	12-20	nuclear factor kappa B subunit 1	Homo sapiens	102-111
31856816-7	2019	However, this effect was lower than 4 mug/mL of curcumin, which inhibited NO, IL-1beta and TNF-alpha production by 89.50 +- 5.00%, 78.80 +- 6.20% and 87.30 +- 4.00%, respectively.	Curcumin	48-56	interleukin 1 beta	Mus musculus	78-86
31856816-7	2019	However, this effect was lower than 4 mug/mL of curcumin, which inhibited NO, IL-1beta and TNF-alpha production by 89.50 +- 5.00%, 78.80 +- 6.20% and 87.30 +- 4.00%, respectively.	Curcumin	48-56	tumor necrosis factor	Mus musculus	91-100
31841506-0	2019	Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments.	Curcumin	51-59	mechanistic target of rapamycin kinase	Homo sapiens	114-118
31629984-8	2019	curcumin may regulate the activation of autophagy in EAE mice by affecting the AKT/mTOR autophagy signalling pathway, further balancing central nervous system and peripheral autophagy.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	79-82
31773117-0	2019	Curcumin inhibits cigarette smoke-induced inflammation via modulating the PPARgamma-NF-kappaB signaling pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	84-93
31818040-6	2019	Curcumin supplementation reduced the production of serum pro-inflammatory cytokines, attenuated insulin resistance and hepatic triglyceride, and enhanced the hepatic glycogen concentrations and lipase activities of IUGR piglets.	Curcumin	0-8	insulin	Homo sapiens	96-103
31818040-7	2019	The hepatic mRNA expressions of the insulin-signaling pathway and lipogenic pathway were influenced by IUGR and were positively attenuated by diets supplemented with curcumin.	Curcumin	166-174	insulin	Homo sapiens	36-43
31818040-9	2019	Diets supplemented with curcumin improved growth, attenuated insulin resistance, and reduced lipid levels in the liver by regulating the hepatic gene expressions of the related signaling pathway in IUGR piglets.	Curcumin	24-32	insulin	Homo sapiens	61-68
31817533-0	2019	Dietary Curcumin Supplementation Increases Antioxidant Capacity, Upregulates Nrf2 and Hmox1 Levels in the Liver of Piglet Model with Intrauterine Growth Retardation.	Curcumin	8-16	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
31817533-8	2019	Dietary curcumin supplementation increased body-weight gain, feed intake, activities of antioxidant enzymes, and the expressions of nuclear factor, erythroid 2-like 2 (Nrf2) and heme oxygenase-1 (Hmox1) proteins in the liver of weaned piglets with IUGR.	Curcumin	8-16	NFE2 like bZIP transcription factor 2	Homo sapiens	132-166
31817533-8	2019	Dietary curcumin supplementation increased body-weight gain, feed intake, activities of antioxidant enzymes, and the expressions of nuclear factor, erythroid 2-like 2 (Nrf2) and heme oxygenase-1 (Hmox1) proteins in the liver of weaned piglets with IUGR.	Curcumin	8-16	NFE2 like bZIP transcription factor 2	Homo sapiens	168-172
31817533-10	2019	Curcumin could efficiently improve the growth, increase hepatic antioxidant capacity, and upregulate Nrf2 and Hmox1 levels in the liver of IUGR weaned piglets.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
31027431-6	2019	RESULTS: Our study showed that the chrysin-curcumin-loaded nanofibres have anti-inflammatory properties in several stages of the wound-healing process by affecting the IL-6, MMP-2, TIMP-1, TIMP-2 and iNOS gene expression.	Curcumin	43-51	interleukin 6	Rattus norvegicus	168-172
31027431-6	2019	RESULTS: Our study showed that the chrysin-curcumin-loaded nanofibres have anti-inflammatory properties in several stages of the wound-healing process by affecting the IL-6, MMP-2, TIMP-1, TIMP-2 and iNOS gene expression.	Curcumin	43-51	nitric oxide synthase 2	Rattus norvegicus	200-204
31724938-9	2019	Curcumin significantly reduced MDA [SMD -0.46 (95% CI: -0.68 to -0.25)] and increased superoxide dismutase (SOD) [0.82 (0.27 to 1.38)], catalase [10.26 (0.92 to 19.61)], and glutathione peroxidase [8.90 (6.62 to 11.19)] when compared with control group.	Curcumin	0-8	superoxide dismutase 1	Homo sapiens	86-106
31724938-9	2019	Curcumin significantly reduced MDA [SMD -0.46 (95% CI: -0.68 to -0.25)] and increased superoxide dismutase (SOD) [0.82 (0.27 to 1.38)], catalase [10.26 (0.92 to 19.61)], and glutathione peroxidase [8.90 (6.62 to 11.19)] when compared with control group.	Curcumin	0-8	superoxide dismutase 1	Homo sapiens	108-111
31724938-10	2019	Subgroup analyses displayed that curcumin could significantly reduce MDA levels with or without use of piperine, however it could increase SOD level in presence of piperine.	Curcumin	33-41	superoxide dismutase 1	Homo sapiens	139-142
31539270-8	2019	Compared with control group, curcumin significantly inhibited cell cycle progression in G0/G1-S phase, increased the cell number of G0/G1 phase, and downregulated the Bcl-2, CDK4, and cyclin D1 protein expression in cells and tissues (p &lt; 0.05).	Curcumin	29-37	BCL2 apoptosis regulator	Homo sapiens	167-172
31751886-10	2019	Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation.	Curcumin	9-17	tumor necrosis factor	Homo sapiens	88-97
31751886-10	2019	Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation.	Curcumin	9-17	interleukin 6	Homo sapiens	99-103
31751886-10	2019	Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation.	Curcumin	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	109-114
31751886-10	2019	Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation.	Curcumin	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
31780025-1	2019	OBJECTIVE: The aim of the current study was to assess the effects of curcumin supplementation on glycemic status, lipid profile and high sensitivity C-reactive protein (hs-CRP) serum levels in women with polycystic ovary syndrome (PCOS).	Curcumin	69-77	C-reactive protein	Homo sapiens	149-167
31780025-8	2019	CONCLUSIONS: Curcumin supplementation might be beneficial for improving serum insulin and QUICKI, however, future investigations are suggested in order to draw a firm link between curcumin and glycemia control.	Curcumin	13-21	insulin	Homo sapiens	78-85
31549866-8	2019	Pretreatment with curcumin (alone and via MSNs) significantly protected myocardium from the toxic effects of DOX by significantly decreased the elevated level of malondialdehyde and increased the reduced level of reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) in cardiac tissue.	Curcumin	18-26	catalase	Rattus norvegicus	281-284
31745802-10	2019	Oral administration of curcumin and taurine to BPA-exposed rats significantly reversed the content of lipid peroxidation products, as well as enhanced the activities of GPx and GST, CAT, and SOD enzymes.	Curcumin	23-31	catalase	Rattus norvegicus	182-185
31798724-2	2019	The aim of this study was to determine how curcumin (CRM) used as an adjuvant supports the apoptotic process induced by a single chemical agent treatment (cisplatin-CisPT) on two head and neck squamous cell carcinoma cell lines (FaDu and PE/CA-PJ49) and the involvement of ERK1/2 and/or p53 activation in this process.	Curcumin	43-51	mitogen-activated protein kinase 3	Homo sapiens	273-279
31798724-2	2019	The aim of this study was to determine how curcumin (CRM) used as an adjuvant supports the apoptotic process induced by a single chemical agent treatment (cisplatin-CisPT) on two head and neck squamous cell carcinoma cell lines (FaDu and PE/CA-PJ49) and the involvement of ERK1/2 and/or p53 activation in this process.	Curcumin	43-51	tumor protein p53	Homo sapiens	287-290
31798724-2	2019	The aim of this study was to determine how curcumin (CRM) used as an adjuvant supports the apoptotic process induced by a single chemical agent treatment (cisplatin-CisPT) on two head and neck squamous cell carcinoma cell lines (FaDu and PE/CA-PJ49) and the involvement of ERK1/2 and/or p53 activation in this process.	Curcumin	53-56	mitogen-activated protein kinase 3	Homo sapiens	273-279
31798724-2	2019	The aim of this study was to determine how curcumin (CRM) used as an adjuvant supports the apoptotic process induced by a single chemical agent treatment (cisplatin-CisPT) on two head and neck squamous cell carcinoma cell lines (FaDu and PE/CA-PJ49) and the involvement of ERK1/2 and/or p53 activation in this process.	Curcumin	53-56	tumor protein p53	Homo sapiens	287-290
31798724-4	2019	CRM induced an increase of p53 protein phosphorylation in both cell lines.	Curcumin	0-3	tumor protein p53	Homo sapiens	27-30
31798724-7	2019	ERK1/2 activation status was essential for both cell processes, proliferation and apoptosis induced by CisPt and/or CRM treatment on squamous cell carcinoma cells.	Curcumin	116-119	mitogen-activated protein kinase 3	Homo sapiens	0-6
31798724-8	2019	Our data suggest that p53 phosphorylation in the apoptotic process induced by CRM treatment might require the involvement of ERK1/2.	Curcumin	78-81	tumor protein p53	Homo sapiens	22-25
31798724-8	2019	Our data suggest that p53 phosphorylation in the apoptotic process induced by CRM treatment might require the involvement of ERK1/2.	Curcumin	78-81	mitogen-activated protein kinase 3	Homo sapiens	125-131
31798724-10	2019	Moreover, in both tumor cell lines our results support the involvement of p53 phosphorylation-ERK1/2 activation-dependent in the apoptosis induced by combined treatments (CisPt and CRM).	Curcumin	181-184	tumor protein p53	Homo sapiens	74-77
31798724-10	2019	Moreover, in both tumor cell lines our results support the involvement of p53 phosphorylation-ERK1/2 activation-dependent in the apoptosis induced by combined treatments (CisPt and CRM).	Curcumin	181-184	mitogen-activated protein kinase 3	Homo sapiens	94-100
31798724-11	2019	The use of CRM as adjuvant could increase the efficiency of chemotherapy by modulating cellular activation processes of ERK1/2 signaling pathways.	Curcumin	11-14	mitogen-activated protein kinase 3	Homo sapiens	120-126
31499117-3	2019	In this work, we have tried the naturally occurring polyphenol, curcumin, for probing the aggregation of the serum protein bovine serum albumin (BSA) in crowded environments.	Curcumin	64-72	albumin	Homo sapiens	130-143
31773117-6	2019	Importantly, we found that the inhibitory effect on NF-kappaB by curcumin was dependent on PPARgamma in T0070907-treated or PPARgamma shRNA-transfected Beas-2B cells, indicating that curcumin inhibited CSE-induced inflammation partially through modulating the PPARgamma-NF-kappaB pathway.	Curcumin	65-73	nuclear factor kappa B subunit 1	Homo sapiens	270-279
31773117-6	2019	Importantly, we found that the inhibitory effect on NF-kappaB by curcumin was dependent on PPARgamma in T0070907-treated or PPARgamma shRNA-transfected Beas-2B cells, indicating that curcumin inhibited CSE-induced inflammation partially through modulating the PPARgamma-NF-kappaB pathway.	Curcumin	183-191	nuclear factor kappa B subunit 1	Homo sapiens	52-61
31773117-8	2019	In conclusion, all the results revealed that curcumin attenuated CS-induced inflammation both in vivo and in vitro, presumably by modulating the PPARgamma-NF-kappaB pathway.	Curcumin	45-53	nuclear factor kappa B subunit 1	Homo sapiens	155-164
31773117-2	2019	Curcumin, a dietary polyphenol isolated from the rhizome of turmeric, has been found to have therapeutic benefits in chronic obstructive pulmonary disease (COPD) via inhibiting NF-kappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	177-186
31773117-3	2019	However, whether the anti-inflammatory efficacy of curcumin in COPD is associated with PPARgamma has scarcely been investigated before.	Curcumin	51-59	peroxisome proliferator activated receptor gamma	Homo sapiens	87-96
31773117-4	2019	The purpose of this study was to validate the relationship between PPARgamma and NF-kappaB in cigarette smoke (CS)-induced COPD models, and then to investigate whether the therapeutic effect of curcumin on COPD is achieved through modulating the PPARgamma-NF-kappaB signaling pathway.	Curcumin	194-202	nuclear factor kappa B subunit 1	Homo sapiens	256-265
31773117-5	2019	Our experiments in vitro illustrated that PPARgamma might be upstream of NF-kappaB in cigarette smoke extract (CSE)-treated Beas-2B cells, and that curcumin could significantly ameliorate CSE-induced cell viability reduction and inflammation though up-regulating PPARgamma and inhibiting NF-kappaB activation.	Curcumin	148-156	peroxisome proliferator activated receptor gamma	Homo sapiens	263-272
31773117-5	2019	Our experiments in vitro illustrated that PPARgamma might be upstream of NF-kappaB in cigarette smoke extract (CSE)-treated Beas-2B cells, and that curcumin could significantly ameliorate CSE-induced cell viability reduction and inflammation though up-regulating PPARgamma and inhibiting NF-kappaB activation.	Curcumin	148-156	nuclear factor kappa B subunit 1	Homo sapiens	288-297
31773117-6	2019	Importantly, we found that the inhibitory effect on NF-kappaB by curcumin was dependent on PPARgamma in T0070907-treated or PPARgamma shRNA-transfected Beas-2B cells, indicating that curcumin inhibited CSE-induced inflammation partially through modulating the PPARgamma-NF-kappaB pathway.	Curcumin	65-73	nuclear factor kappa B subunit 1	Homo sapiens	52-61
31773117-6	2019	Importantly, we found that the inhibitory effect on NF-kappaB by curcumin was dependent on PPARgamma in T0070907-treated or PPARgamma shRNA-transfected Beas-2B cells, indicating that curcumin inhibited CSE-induced inflammation partially through modulating the PPARgamma-NF-kappaB pathway.	Curcumin	65-73	peroxisome proliferator activated receptor gamma	Homo sapiens	91-100
31773117-6	2019	Importantly, we found that the inhibitory effect on NF-kappaB by curcumin was dependent on PPARgamma in T0070907-treated or PPARgamma shRNA-transfected Beas-2B cells, indicating that curcumin inhibited CSE-induced inflammation partially through modulating the PPARgamma-NF-kappaB pathway.	Curcumin	65-73	peroxisome proliferator activated receptor gamma	Homo sapiens	124-133
31675556-0	2019	Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib.	Curcumin	0-8	mitogen-activated protein kinase kinase 7	Homo sapiens	24-27
31485636-9	2019	Following treatment with curcumin, PQ-induced increases in ROS levels and apoptosis were significantly attenuated, and Bcl-2 expression levels were upregulated, whereas those of Bax were downregulated.	Curcumin	25-33	BCL2 apoptosis regulator	Homo sapiens	119-124
31675556-6	2019	Mechanistically, curcumin behaved like MEK-specific inhibitor (U0126) to enhance regorafenib-induced growth inhibition, apoptosis and autophagy in HCT 116 cells.	Curcumin	17-25	mitogen-activated protein kinase kinase 7	Homo sapiens	39-42
31485636-9	2019	Following treatment with curcumin, PQ-induced increases in ROS levels and apoptosis were significantly attenuated, and Bcl-2 expression levels were upregulated, whereas those of Bax were downregulated.	Curcumin	25-33	BCL2 associated X, apoptosis regulator	Homo sapiens	178-181
31485636-10	2019	It was also observed that curcumin treatment downregulated the expression levels of TXNIP, NLRP3, interleukin (IL)-1beta and IL-18, and downstream caspase-1 compared with PQ treatment alone.	Curcumin	26-34	thioredoxin interacting protein	Homo sapiens	84-89
31485636-10	2019	It was also observed that curcumin treatment downregulated the expression levels of TXNIP, NLRP3, interleukin (IL)-1beta and IL-18, and downstream caspase-1 compared with PQ treatment alone.	Curcumin	26-34	NLR family pyrin domain containing 3	Homo sapiens	91-96
31485636-10	2019	It was also observed that curcumin treatment downregulated the expression levels of TXNIP, NLRP3, interleukin (IL)-1beta and IL-18, and downstream caspase-1 compared with PQ treatment alone.	Curcumin	26-34	interleukin 1 beta	Homo sapiens	98-120
31485636-10	2019	It was also observed that curcumin treatment downregulated the expression levels of TXNIP, NLRP3, interleukin (IL)-1beta and IL-18, and downstream caspase-1 compared with PQ treatment alone.	Curcumin	26-34	caspase 1	Homo sapiens	147-156
31485636-11	2019	Curcumin significantly attenuated the upregulation of Notch1 without affecting ERK1/2 phosphorylation.	Curcumin	0-8	notch receptor 1	Homo sapiens	54-60
30957612-6	2019	RESULTS: High dose curcumin could partly ameliorate the intolerance of glucose and insulin, and completely restore the litter size and the body weight of GD mice through decreased TBARS expression (p &lt; 0.05) and increased GSH, SOD and CAT expression (p &lt; 0.05).	Curcumin	19-27	catalase	Mus musculus	238-241
30957612-7	2019	Enhanced AMPK activation, accompanied with decreased HDAC4 and G6Pase expression (p &lt; 0.05) were partly contributed to the alleviation of GD mediated by curcumin.	Curcumin	156-164	histone deacetylase 4	Mus musculus	53-58
31741405-8	2019	Furthermore, curcumin upregulated the expression of E-cadherin and LC3 proteins and downregulated the vimentin, TWIST1, p62, p-mTOR, p-Akt and P13K levels in DN rats and MPC5 cells.	Curcumin	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	135-138
31741405-9	2019	However, fumonisin B1 or 3BDO reversed the effects of curcumin on the expression of these proteins in cells.Discussion and conclusions: The protection against development of DN by curcumin treatment involved changes in inducing autophagy and alleviating podocyte EMT, through the PI3k/Akt/mTOR pathway, providing the scientific basis for further research and clinical applications of curcumin.	Curcumin	54-62	AKT serine/threonine kinase 1	Rattus norvegicus	285-288
31741405-9	2019	However, fumonisin B1 or 3BDO reversed the effects of curcumin on the expression of these proteins in cells.Discussion and conclusions: The protection against development of DN by curcumin treatment involved changes in inducing autophagy and alleviating podocyte EMT, through the PI3k/Akt/mTOR pathway, providing the scientific basis for further research and clinical applications of curcumin.	Curcumin	180-188	AKT serine/threonine kinase 1	Rattus norvegicus	285-288
31741405-9	2019	However, fumonisin B1 or 3BDO reversed the effects of curcumin on the expression of these proteins in cells.Discussion and conclusions: The protection against development of DN by curcumin treatment involved changes in inducing autophagy and alleviating podocyte EMT, through the PI3k/Akt/mTOR pathway, providing the scientific basis for further research and clinical applications of curcumin.	Curcumin	180-188	AKT serine/threonine kinase 1	Rattus norvegicus	285-288
31590042-0	2019	Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-kappaB pathways in BV2 cells.	Curcumin	0-8	toll-like receptor 4	Mus musculus	99-103
31590042-0	2019	Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-kappaB pathways in BV2 cells.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	105-114
31590042-14	2019	Curcumin treatment switched the M1 pro-inflammatory phenotype to the M2 anti-inflammatory phenotype by decreasing the expression of M1 markers (i.e., iNOS, IL-1beta, IL-6, and CD16/32) and elevating the expression of M2 markers (i.e., arginase 1, IL-4, IL-10, and CD206).	Curcumin	0-8	nitric oxide synthase 2, inducible	Mus musculus	150-154
31590042-14	2019	Curcumin treatment switched the M1 pro-inflammatory phenotype to the M2 anti-inflammatory phenotype by decreasing the expression of M1 markers (i.e., iNOS, IL-1beta, IL-6, and CD16/32) and elevating the expression of M2 markers (i.e., arginase 1, IL-4, IL-10, and CD206).	Curcumin	0-8	interleukin 6	Mus musculus	166-170
31590042-14	2019	Curcumin treatment switched the M1 pro-inflammatory phenotype to the M2 anti-inflammatory phenotype by decreasing the expression of M1 markers (i.e., iNOS, IL-1beta, IL-6, and CD16/32) and elevating the expression of M2 markers (i.e., arginase 1, IL-4, IL-10, and CD206).	Curcumin	0-8	interleukin 10	Mus musculus	253-258
31590042-15	2019	Interestingly, curcumin attenuated the activation of TLR4/NF-kappaB pathways and the downregulation of TREM2 expression in LPS-activated BV2 cells.	Curcumin	15-23	toll-like receptor 4	Mus musculus	53-57
31590042-15	2019	Interestingly, curcumin attenuated the activation of TLR4/NF-kappaB pathways and the downregulation of TREM2 expression in LPS-activated BV2 cells.	Curcumin	15-23	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	58-67
31590042-16	2019	Collectively, these results suggest that curcumin significantly alleviates LPS-induced inflammation by regulating microglial (M1/M2) polarization by reducing the imbalance of TREM2 and TLR4 and balancing the downstream NF-kappaB activation.	Curcumin	41-49	toll-like receptor 4	Mus musculus	185-189
31590042-16	2019	Collectively, these results suggest that curcumin significantly alleviates LPS-induced inflammation by regulating microglial (M1/M2) polarization by reducing the imbalance of TREM2 and TLR4 and balancing the downstream NF-kappaB activation.	Curcumin	41-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	219-228
31807190-13	2019	Western blot analysis revealed that ABCC2 protein expression increased, and DCK, TK1 and TK2 expression decreased following co-treatment of T24-GCB cells with GCB + curcumin or resveratrol compared with GCB alone.	Curcumin	165-173	thymidine kinase 1	Homo sapiens	81-84
31807190-14	2019	Of note, there was a marked increase in cleaved-PARP expression in T24-GCB cells treated with a combination of GCB + curcumin or resveratrol.	Curcumin	117-125	poly(ADP-ribose) polymerase 1	Homo sapiens	48-52
31807190-15	2019	Both curcumin and resveratrol could reverse the drug resistance of T24-GCB cells in an additive pattern though PARP enhancement without changes in ABCC2 and DCK, TK1 and TK2 expression.	Curcumin	5-13	poly(ADP-ribose) polymerase 1	Homo sapiens	111-115
31485636-12	2019	The present findings suggested that the inhibitory effects of curcumin on TXINP1 may inhibit activation of the NLRP3 inflammasome, subsequently suppressing the upregulation of proinflammatory cytokines and ultimately improving PQ-induced ALI.	Curcumin	62-70	NLR family pyrin domain containing 3	Homo sapiens	111-116
31421247-12	2019	The SCI-hyperglycemia-curcumin group showed a statistically significant reduction in IL-6, IL-8, and TNF-alpha levels compared with the SCI-hyperglycemia group after SCI.	Curcumin	22-30	interleukin 6	Rattus norvegicus	85-89
31421247-12	2019	The SCI-hyperglycemia-curcumin group showed a statistically significant reduction in IL-6, IL-8, and TNF-alpha levels compared with the SCI-hyperglycemia group after SCI.	Curcumin	22-30	tumor necrosis factor	Rattus norvegicus	101-110
31788011-11	2019	Curcumin also markedly down-regulated the protein expression of hepatic TLR4 and myeloid differentiation factor 88 (MyD88), inhibited p65 nuclear translocation and DNA binding activity of nuclear factor-kappaB (NF-kappaB) in the liver.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	211-220
31819412-2	2019	The aim of this study was to assess the anti-inflammatory comparative effect of curcumin solution with liposomal curcumin formula, regarding the improvement of serum levels of TNF-alpha (tumor necrosis factor-alpha), IL-6 (interleukin), IL-1alpha, IL-1beta, MCP-1 (monocyte chemoattractant protein-1) and RANTES in experimental diabetes, induced by streptozotocin (STZ), in rats.	Curcumin	80-88	tumor necrosis factor	Rattus norvegicus	176-185
31819412-2	2019	The aim of this study was to assess the anti-inflammatory comparative effect of curcumin solution with liposomal curcumin formula, regarding the improvement of serum levels of TNF-alpha (tumor necrosis factor-alpha), IL-6 (interleukin), IL-1alpha, IL-1beta, MCP-1 (monocyte chemoattractant protein-1) and RANTES in experimental diabetes, induced by streptozotocin (STZ), in rats.	Curcumin	80-88	tumor necrosis factor	Rattus norvegicus	187-214
31819412-2	2019	The aim of this study was to assess the anti-inflammatory comparative effect of curcumin solution with liposomal curcumin formula, regarding the improvement of serum levels of TNF-alpha (tumor necrosis factor-alpha), IL-6 (interleukin), IL-1alpha, IL-1beta, MCP-1 (monocyte chemoattractant protein-1) and RANTES in experimental diabetes, induced by streptozotocin (STZ), in rats.	Curcumin	80-88	interleukin 6	Rattus norvegicus	217-221
31819412-2	2019	The aim of this study was to assess the anti-inflammatory comparative effect of curcumin solution with liposomal curcumin formula, regarding the improvement of serum levels of TNF-alpha (tumor necrosis factor-alpha), IL-6 (interleukin), IL-1alpha, IL-1beta, MCP-1 (monocyte chemoattractant protein-1) and RANTES in experimental diabetes, induced by streptozotocin (STZ), in rats.	Curcumin	80-88	interleukin 1 alpha	Rattus norvegicus	237-246
31819412-2	2019	The aim of this study was to assess the anti-inflammatory comparative effect of curcumin solution with liposomal curcumin formula, regarding the improvement of serum levels of TNF-alpha (tumor necrosis factor-alpha), IL-6 (interleukin), IL-1alpha, IL-1beta, MCP-1 (monocyte chemoattractant protein-1) and RANTES in experimental diabetes, induced by streptozotocin (STZ), in rats.	Curcumin	80-88	interleukin 1 beta	Rattus norvegicus	248-256
31819412-2	2019	The aim of this study was to assess the anti-inflammatory comparative effect of curcumin solution with liposomal curcumin formula, regarding the improvement of serum levels of TNF-alpha (tumor necrosis factor-alpha), IL-6 (interleukin), IL-1alpha, IL-1beta, MCP-1 (monocyte chemoattractant protein-1) and RANTES in experimental diabetes, induced by streptozotocin (STZ), in rats.	Curcumin	113-121	tumor necrosis factor	Rattus norvegicus	176-185
31819412-2	2019	The aim of this study was to assess the anti-inflammatory comparative effect of curcumin solution with liposomal curcumin formula, regarding the improvement of serum levels of TNF-alpha (tumor necrosis factor-alpha), IL-6 (interleukin), IL-1alpha, IL-1beta, MCP-1 (monocyte chemoattractant protein-1) and RANTES in experimental diabetes, induced by streptozotocin (STZ), in rats.	Curcumin	113-121	tumor necrosis factor	Rattus norvegicus	187-214
31803007-0	2019	Curcumin Mitigates Neuro-Inflammation by Modulating Microglia Polarization Through Inhibiting TLR4 Axis Signaling Pathway Following Experimental Subarachnoid Hemorrhage.	Curcumin	0-8	toll-like receptor 4	Mus musculus	94-98
31803007-3	2019	In this study, we verified the hypothesis curcumin promotes M2 polarization to inhibiting neuro-inflammation, which through suppressing TLR4 signaling pathway after SAH.	Curcumin	42-50	toll-like receptor 4	Mus musculus	136-140
31803007-10	2019	Meanwhile, curcumin treatment also decreased the expressions of TLR4, Myd88 and NF-kappaB at 24 h post SAH.	Curcumin	11-19	toll-like receptor 4	Mus musculus	64-68
31803007-10	2019	Meanwhile, curcumin treatment also decreased the expressions of TLR4, Myd88 and NF-kappaB at 24 h post SAH.	Curcumin	11-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	80-89
31803007-12	2019	Moreover, curcumin treatment in tlr4-/- mice further induced M2 polarization, while had no statistic difference on brain water content and neurological score at 24 h post SAH.	Curcumin	10-18	toll-like receptor 4	Mus musculus	32-36
31803007-13	2019	Our results indicated that curcumin treatment alleviated neuro-inflammation response through promoting microglia phenotype shift toward M2, and which might inhibiting TLR4/MyD88/NF-kappaB signaling pathway after SAH.	Curcumin	27-35	toll-like receptor 4	Mus musculus	167-171
31803007-13	2019	Our results indicated that curcumin treatment alleviated neuro-inflammation response through promoting microglia phenotype shift toward M2, and which might inhibiting TLR4/MyD88/NF-kappaB signaling pathway after SAH.	Curcumin	27-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	178-187
31754130-4	2019	Therefore, the aim of this study was to investigate the effects of curcumin on SFRP5 DNA methylation modification in an ovarian cancer cell line (SKOV3).	Curcumin	67-75	secreted frizzled related protein 5	Homo sapiens	79-84
31754130-6	2019	The results showed that curcumin combined with 5 muM DAC may inhibit cancer cell colony formation, migration through EMT (epithelial-mesenchymal transition) process regulation, total DNMT activity, especially in DNMT3a protein expression, and may also regulate tumor suppressor gene SFRP5 expression involved in the Wnt/beta-catenin signaling pathway.	Curcumin	24-32	secreted frizzled related protein 5	Homo sapiens	283-288
31752145-0	2019	Curcumin Nicotinate Selectively Induces Cancer Cell Apoptosis and Cycle Arrest through a P53-Mediated Mechanism.	Curcumin	0-19	tumor protein p53	Homo sapiens	89-92
31752145-3	2019	Our data showed that CN effectively inhibited proliferation and clonogenic growth of colon (HCT116), breast (MCF-7) and nasopharyngeal (CNE2, 5-8F and 6-10B) cancer cells with IC50 at 27.7 muM, 73.4 muM, 64.7 muM, 46.3 muM, and 31.2 muM, respectively.	Curcumin	21-23	latexin	Homo sapiens	189-192
31752145-3	2019	Our data showed that CN effectively inhibited proliferation and clonogenic growth of colon (HCT116), breast (MCF-7) and nasopharyngeal (CNE2, 5-8F and 6-10B) cancer cells with IC50 at 27.7 muM, 73.4 muM, 64.7 muM, 46.3 muM, and 31.2 muM, respectively.	Curcumin	21-23	latexin	Homo sapiens	199-202
31752145-3	2019	Our data showed that CN effectively inhibited proliferation and clonogenic growth of colon (HCT116), breast (MCF-7) and nasopharyngeal (CNE2, 5-8F and 6-10B) cancer cells with IC50 at 27.7 muM, 73.4 muM, 64.7 muM, 46.3 muM, and 31.2 muM, respectively.	Curcumin	21-23	latexin	Homo sapiens	199-202
31752145-3	2019	Our data showed that CN effectively inhibited proliferation and clonogenic growth of colon (HCT116), breast (MCF-7) and nasopharyngeal (CNE2, 5-8F and 6-10B) cancer cells with IC50 at 27.7 muM, 73.4 muM, 64.7 muM, 46.3 muM, and 31.2 muM, respectively.	Curcumin	21-23	latexin	Homo sapiens	199-202
31752145-3	2019	Our data showed that CN effectively inhibited proliferation and clonogenic growth of colon (HCT116), breast (MCF-7) and nasopharyngeal (CNE2, 5-8F and 6-10B) cancer cells with IC50 at 27.7 muM, 73.4 muM, 64.7 muM, 46.3 muM, and 31.2 muM, respectively.	Curcumin	21-23	latexin	Homo sapiens	199-202
31752145-4	2019	In cancer cells, CN induced apoptosis and cell cycle arrest at G2/M phase through a p53-mediated mechanism, where p53 was activated, p21 and pro-apoptotic proteins Bid and Bak were upregulated, and PARP was cleaved.	Curcumin	17-19	tumor protein p53	Homo sapiens	84-87
31752145-4	2019	In cancer cells, CN induced apoptosis and cell cycle arrest at G2/M phase through a p53-mediated mechanism, where p53 was activated, p21 and pro-apoptotic proteins Bid and Bak were upregulated, and PARP was cleaved.	Curcumin	17-19	tumor protein p53	Homo sapiens	114-117
31752145-4	2019	In cancer cells, CN induced apoptosis and cell cycle arrest at G2/M phase through a p53-mediated mechanism, where p53 was activated, p21 and pro-apoptotic proteins Bid and Bak were upregulated, and PARP was cleaved.	Curcumin	17-19	BH3 interacting domain death agonist	Homo sapiens	164-167
31752145-4	2019	In cancer cells, CN induced apoptosis and cell cycle arrest at G2/M phase through a p53-mediated mechanism, where p53 was activated, p21 and pro-apoptotic proteins Bid and Bak were upregulated, and PARP was cleaved.	Curcumin	17-19	poly(ADP-ribose) polymerase 1	Homo sapiens	198-202
31752145-5	2019	In non-transformed human mammary epithelial cells MCF10A, CN at 50 microM had no cytotoxicity and p53 was not activated, but curcumin at 12.5 microM activated p53 and p21 and inhibited MCF10A cell growth.	Curcumin	125-133	tumor protein p53	Homo sapiens	159-162
31752145-6	2019	These data suggest that CN inhibits cell growth and proliferation through p53-mediated apoptosis and cell cycle arrest with cancer cell selectivity.	Curcumin	24-26	tumor protein p53	Homo sapiens	74-77
31788011-0	2019	Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE-/- mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-kappaB inflammation.	Curcumin	0-8	apolipoprotein E	Mus musculus	61-65
31788011-0	2019	Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE-/- mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-kappaB inflammation.	Curcumin	0-8	toll-like receptor 4	Mus musculus	148-152
31788011-0	2019	Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE-/- mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-kappaB inflammation.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	153-162
31788011-10	2019	Moreover, curcumin up-regulated the expression of intestinal tight junction protein zonula occluden-1 and occludin, which further improved gut barrier dysfunction and reduced circulating lipopolysaccharide levels.	Curcumin	10-18	occludin	Mus musculus	61-114
31788011-11	2019	Curcumin also markedly down-regulated the protein expression of hepatic TLR4 and myeloid differentiation factor 88 (MyD88), inhibited p65 nuclear translocation and DNA binding activity of nuclear factor-kappaB (NF-kappaB) in the liver.	Curcumin	0-8	toll-like receptor 4	Mus musculus	72-76
31788011-11	2019	Curcumin also markedly down-regulated the protein expression of hepatic TLR4 and myeloid differentiation factor 88 (MyD88), inhibited p65 nuclear translocation and DNA binding activity of nuclear factor-kappaB (NF-kappaB) in the liver.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	188-209
31788011-12	2019	In addition, the mRNA expression of hepatic tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) as well as the plasma levels of TNF-alpha and IL-1beta were also lowered by curcumin treatment.	Curcumin	194-202	interleukin 1 beta	Mus musculus	89-106
31788011-12	2019	In addition, the mRNA expression of hepatic tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) as well as the plasma levels of TNF-alpha and IL-1beta were also lowered by curcumin treatment.	Curcumin	194-202	interleukin 1 beta	Mus musculus	164-172
31788011-13	2019	Conclusion: These results indicated that curcumin protects against HFD-induced hepatic steatosis by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-kappaB inflammation.	Curcumin	41-49	toll-like receptor 4	Mus musculus	171-175
31788011-13	2019	Conclusion: These results indicated that curcumin protects against HFD-induced hepatic steatosis by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-kappaB inflammation.	Curcumin	41-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	176-185
31739443-11	2019	Among phytochemicals, curcumin treatment significantly inhibited the concentration and activity of ACE, concentration of AngII, and mRNA expression of ACE.	Curcumin	22-30	angiotensin I converting enzyme	Rattus norvegicus	99-102
31739443-11	2019	Among phytochemicals, curcumin treatment significantly inhibited the concentration and activity of ACE, concentration of AngII, and mRNA expression of ACE.	Curcumin	22-30	angiotensinogen	Rattus norvegicus	121-126
31739443-11	2019	Among phytochemicals, curcumin treatment significantly inhibited the concentration and activity of ACE, concentration of AngII, and mRNA expression of ACE.	Curcumin	22-30	angiotensin I converting enzyme	Rattus norvegicus	151-154
31703057-5	2019	Curcumin, a specific activator of extracellular signal regulated kinases (ERK1/2), or PD98059, a specific inhibitor of ERK1/2, was used to activate or block the ERK1/2 pathway, respectively.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	74-80
31717261-12	2019	Conversely, the expressions of superoxide dismutase 1 (SOD1) and SIRT1 were significantly upregulated by curcumin treatment.	Curcumin	105-113	superoxide dismutase 1, soluble	Mus musculus	31-53
31798458-11	2019	However, immediate post-treatment with curcumin was significantly neuroprotective, reducing grey and white matter tissue loss, TUNEL+ cell death, microglia activation, reactive astrogliosis, and iNOS oxidative stress when compared to vehicle-treated littermates.	Curcumin	39-47	nitric oxide synthase 2, inducible	Mus musculus	195-199
31717261-12	2019	Conversely, the expressions of superoxide dismutase 1 (SOD1) and SIRT1 were significantly upregulated by curcumin treatment.	Curcumin	105-113	superoxide dismutase 1, soluble	Mus musculus	55-59
31703057-9	2019	Interestingly, the inhibitory effect of TRIM48 overexpression on human GBM cell growth and the inactivation of ERK1/2 were significantly alleviated with additional curcumin treatment, while it the promoted the effect of siTRIM48 on human GBM cell growth, and the activation of ERK1/2 was significantly alleviated with additional PD98059 treatment.	Curcumin	164-172	mitogen-activated protein kinase 3	Homo sapiens	111-117
31703744-0	2019	Curcumin derivative WZ35 inhibits tumor cell growth via ROS-YAP-JNK signaling pathway in breast cancer.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	64-67
31703057-9	2019	Interestingly, the inhibitory effect of TRIM48 overexpression on human GBM cell growth and the inactivation of ERK1/2 were significantly alleviated with additional curcumin treatment, while it the promoted the effect of siTRIM48 on human GBM cell growth, and the activation of ERK1/2 was significantly alleviated with additional PD98059 treatment.	Curcumin	164-172	mitogen-activated protein kinase 3	Homo sapiens	277-283
31827700-0	2019	Dietary Supplementation of the Antioxidant Curcumin Halts Systemic LPS-Induced Neuroinflammation-Associated Neurodegeneration and Memory/Synaptic Impairment via the JNK/NF-kappaB/Akt Signaling Pathway in Adult Rats.	Curcumin	43-51	AKT serine/threonine kinase 1	Rattus norvegicus	179-182
31827700-2	2019	In the present study, we explored the neuroprotective effect of curcumin against lipopolysaccharide- (LPS-) induced reactive oxygen species- (ROS-) mediated neuroinflammation, neurodegeneration, and memory deficits in the adult rat hippocampus via regulation of the JNK/NF-kappaB/Akt signaling pathway.	Curcumin	64-72	AKT serine/threonine kinase 1	Rattus norvegicus	280-283
31450166-0	2019	Synthesis and biological evaluation of a novel series of curcumin-peptide derivatives as PepT1-mediated transport drugs.	Curcumin	57-65	solute carrier family 15 member 1	Homo sapiens	89-94
31613624-3	2019	In this study, it was demonstrated that bovine milk could be enriched with curcumin using this approach, without adversely affecting milk fat globule stability.	Curcumin	75-83	Weaning weight-maternal milk	Bos taurus	47-51
31613624-4	2019	The storage stability of the curcumin-enriched bovine milk was assessed when samples were incubated for 60 days at different pH values and temperatures.	Curcumin	29-37	Weaning weight-maternal milk	Bos taurus	54-58
31613624-5	2019	The pH-stability was determined by storing curcumin-enriched milk at 4  C for 60 days at pH 6.5, 7.0, and/or 8.0.	Curcumin	43-51	Weaning weight-maternal milk	Bos taurus	61-65
31613624-6	2019	At this low storage temperature, all milk samples were stable to fat globule aggregation, creaming, curcumin degradation (<13% loss), and color loss.	Curcumin	100-108	Weaning weight-maternal milk	Bos taurus	37-41
31613624-7	2019	The temperature-stability was determined by storing curcumin-enriched milk at pH 7 for 15 days at 4, 20, 37, or 55  C. Curcumin breakdown decreased with decreasing storage temperature: 55  C (43%) > 37  C (21%) > 20  C (10%) > 4  C (5%).	Curcumin	52-60	Weaning weight-maternal milk	Bos taurus	70-74
31613624-7	2019	The temperature-stability was determined by storing curcumin-enriched milk at pH 7 for 15 days at 4, 20, 37, or 55  C. Curcumin breakdown decreased with decreasing storage temperature: 55  C (43%) > 37  C (21%) > 20  C (10%) > 4  C (5%).	Curcumin	119-127	Weaning weight-maternal milk	Bos taurus	70-74
31613624-10	2019	This study shows that a hydrophobic nutraceutical (curcumin) can be loaded into dairy milk products using a simple method, which could facilitate the creation of novel functional foods and beverages.	Curcumin	51-59	Weaning weight-maternal milk	Bos taurus	86-90
31694300-9	2019	In addition, CUR and/or AA activated Akt and inhibited GSK-3beta in Pb(II)-induced rats.	Curcumin	13-16	AKT serine/threonine kinase 1	Rattus norvegicus	37-40
31694300-10	2019	In conclusion, CUR prevents Pb(II) hepatotoxicity via attenuation of oxidative injury and inflammation, activation of Akt and inhibition of GSK-3beta.	Curcumin	15-18	AKT serine/threonine kinase 1	Rattus norvegicus	118-121
31698770-7	2019	We observed that aspartate aminotransferase (AST), alanine aminotransferase (ALT), and glucose levels were significantly reduced in rats treated with high dose co-administration of curcumin (200 mg/kg) compared to BaP alone.	Curcumin	181-189	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	17-43
31698770-7	2019	We observed that aspartate aminotransferase (AST), alanine aminotransferase (ALT), and glucose levels were significantly reduced in rats treated with high dose co-administration of curcumin (200 mg/kg) compared to BaP alone.	Curcumin	181-189	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	45-48
31694300-0	2019	Curcumin Ameliorates Lead-Induced Hepatotoxicity by Suppressing Oxidative Stress and Inflammation, and Modulating Akt/GSK-3beta Signaling Pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	114-117
31313605-7	2019	Notably, among all candidate drugs, curcumin was the most effective for upregulating both the BEST1 and ZO-1 genes in BD-RPEs.	Curcumin	36-44	bestrophin 1	Homo sapiens	94-99
31313605-7	2019	Notably, among all candidate drugs, curcumin was the most effective for upregulating both the BEST1 and ZO-1 genes in BD-RPEs.	Curcumin	36-44	tight junction protein 1	Homo sapiens	104-108
31403228-5	2019	Mechanistically, curcumin significantly attenuated the TGF-beta1-induced Smad and Hedgehog signaling, and upregulated CD109 expression in BECs.	Curcumin	17-25	transforming growth factor beta 1	Homo sapiens	55-64
31650475-0	2019	Protective role of curcumin in cadmium-induced testicular injury in mice by attenuating oxidative stress via Nrf2/ARE pathway.	Curcumin	19-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	109-113
31650475-8	2019	Our results suggested that curcumin could protect against Cd-induced testicular injury via activating the Nrf2/ARE signaling pathway.	Curcumin	27-35	nuclear factor, erythroid derived 2, like 2	Mus musculus	106-110
31762728-12	2019	Curcumin upregulated the expression of PGC-1alpha, NRF1, and Mn-SOD, and downregulated the expression of GRP78, PERK, and IRE1alpha in hepatic tissue.	Curcumin	0-8	nuclear respiratory factor 1	Mus musculus	51-55
32128094-8	2019	Interestingly, 5 microM curcumin, a ROS scavenger, dramatically lowered the TNF-alpha-induced inflammatory response in BMSCs.	Curcumin	24-32	tumor necrosis factor	Homo sapiens	76-85
31016760-7	2019	We found that curcumin treatment significantly reduced HMEC-1 cells viability, migration, and the protein levels of MMP-2, MMP-9, and vascular endothelial growth factor (VEGF) in the presence or absence of ox-LDL.	Curcumin	14-22	vascular endothelial growth factor A	Homo sapiens	134-168
31016760-7	2019	We found that curcumin treatment significantly reduced HMEC-1 cells viability, migration, and the protein levels of MMP-2, MMP-9, and vascular endothelial growth factor (VEGF) in the presence or absence of ox-LDL.	Curcumin	14-22	vascular endothelial growth factor A	Homo sapiens	170-174
31016760-8	2019	Meanwhile, the expression of VEGFR1 and VEGFR2 was repressed by curcumin.	Curcumin	64-72	fms related receptor tyrosine kinase 1	Homo sapiens	29-35
31016760-11	2019	And also, VEGF was a target gene of miR-126, and curcumin could inhibit the activation of PI3K/AKT JAK2/STAT5 signaling pathways via miR-126.	Curcumin	49-57	vascular endothelial growth factor A	Homo sapiens	10-14
31016760-11	2019	And also, VEGF was a target gene of miR-126, and curcumin could inhibit the activation of PI3K/AKT JAK2/STAT5 signaling pathways via miR-126.	Curcumin	49-57	AKT serine/threonine kinase 1	Homo sapiens	95-98
31016760-12	2019	The effects of curcumin and its regulation on miR-126 and VEGF were confirmed in the animal model of AS.	Curcumin	15-23	vascular endothelial growth factor A	Homo sapiens	58-62
31016760-13	2019	To sum up, curcumin exerted potent anti-AS property possibly via upregulating miR-126 and thereby inhibiting PI3K/AKT and JAK2/STAT5 signaling pathways.	Curcumin	11-19	AKT serine/threonine kinase 1	Homo sapiens	114-117
31762728-12	2019	Curcumin upregulated the expression of PGC-1alpha, NRF1, and Mn-SOD, and downregulated the expression of GRP78, PERK, and IRE1alpha in hepatic tissue.	Curcumin	0-8	superoxide dismutase 2, mitochondrial	Mus musculus	61-67
31762728-12	2019	Curcumin upregulated the expression of PGC-1alpha, NRF1, and Mn-SOD, and downregulated the expression of GRP78, PERK, and IRE1alpha in hepatic tissue.	Curcumin	0-8	heat shock protein 5	Mus musculus	105-110
31762728-13	2019	Curcumin also attenuated inflammation by inhibiting the IkappaBalpha-NF-kappaB pathway, which reduced the production of TNF, IL-1beta, and IL-6.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	56-68
31762728-13	2019	Curcumin also attenuated inflammation by inhibiting the IkappaBalpha-NF-kappaB pathway, which reduced the production of TNF, IL-1beta, and IL-6.	Curcumin	0-8	tumor necrosis factor	Mus musculus	120-123
31762728-13	2019	Curcumin also attenuated inflammation by inhibiting the IkappaBalpha-NF-kappaB pathway, which reduced the production of TNF, IL-1beta, and IL-6.	Curcumin	0-8	interleukin 1 beta	Mus musculus	125-133
31762728-13	2019	Curcumin also attenuated inflammation by inhibiting the IkappaBalpha-NF-kappaB pathway, which reduced the production of TNF, IL-1beta, and IL-6.	Curcumin	0-8	interleukin 6	Mus musculus	139-143
31665675-0	2019	Combination of curcumin and luteolin synergistically inhibits TNF-alpha-induced vascular inflammation in human vascular cells and mice.	Curcumin	15-23	tumor necrosis factor	Homo sapiens	62-71
31039839-11	2019	The bovine serum albumin (BSA) protein denaturation assay showed the curcumin loaded CAs to be highly anti-inflammatory while their anti-cancer activity was confirmed by the high cytotoxic activity against MG-63 human osteosarcoma cells.	Curcumin	69-77	albumin	Homo sapiens	11-30
31665675-5	2019	We also found that TNF-alpha-enhanced protein expressions of vascular cell adhesion molecule 1 (VCAM-1), monocyte chemotactic protein-1 (MCP-1) and nuclear factor (NF)-kappaB translocation were synergistically reduced by the combined curcumin and luteolin in EA.hy 926 cells while the individual chemical did not have this inhibitory effect.	Curcumin	234-242	nuclear factor kappa B subunit 1	Homo sapiens	148-174
31665675-6	2019	Consistently, 2 weeks dietary intake of combined curcumin (500 mg/kg) and luteolin (500 mg/kg) in C57BL/6 mice synergistically prevented TNF-alpha-stimulated adhesion of mouse monocytes to aortic endothelium ex vivo as well as the TNF-alpha-increased aortic protein expression of MCP-1 and VCAM-1.	Curcumin	49-57	tumor necrosis factor	Mus musculus	137-146
31665675-6	2019	Consistently, 2 weeks dietary intake of combined curcumin (500 mg/kg) and luteolin (500 mg/kg) in C57BL/6 mice synergistically prevented TNF-alpha-stimulated adhesion of mouse monocytes to aortic endothelium ex vivo as well as the TNF-alpha-increased aortic protein expression of MCP-1 and VCAM-1.	Curcumin	49-57	tumor necrosis factor	Mus musculus	231-240
31665675-7	2019	Therefore, combined curcumin and luteolin at physiological concentrations synergistically inhibits TNF-alpha-induced monocytes adhesion to endothelial cells and expressions of MCP-1 and VCAM-1 via suppressing NF-kappaB translocation into the nucleus.	Curcumin	20-28	tumor necrosis factor	Homo sapiens	99-108
31665675-3	2019	The aims of this study were to investigate whether and how combined curcumin and luteolin synergistically inhibit tumor necrosis factor-alpha (TNF-alpha)-induced monocytes adhesion endothelium, a crucial step of the development of endothelial dysfunction, both in human vascular cells and mouse aortic endothelium.	Curcumin	68-76	tumor necrosis factor	Homo sapiens	114-141
31665675-3	2019	The aims of this study were to investigate whether and how combined curcumin and luteolin synergistically inhibit tumor necrosis factor-alpha (TNF-alpha)-induced monocytes adhesion endothelium, a crucial step of the development of endothelial dysfunction, both in human vascular cells and mouse aortic endothelium.	Curcumin	68-76	tumor necrosis factor	Homo sapiens	143-152
31665675-4	2019	Our results show that combined curcumin (1 muM) and luteolin (0.5 muM) synergistically (combination index is 0.60) inhibited TNF-alpha-induced monocytes adhesion to human EA.hy926 endothelial cells while the individual chemicals did not have such effect at the selected concentrations.	Curcumin	31-39	latexin	Homo sapiens	43-46
31665675-4	2019	Our results show that combined curcumin (1 muM) and luteolin (0.5 muM) synergistically (combination index is 0.60) inhibited TNF-alpha-induced monocytes adhesion to human EA.hy926 endothelial cells while the individual chemicals did not have such effect at the selected concentrations.	Curcumin	31-39	latexin	Homo sapiens	66-69
31665675-7	2019	Therefore, combined curcumin and luteolin at physiological concentrations synergistically inhibits TNF-alpha-induced monocytes adhesion to endothelial cells and expressions of MCP-1 and VCAM-1 via suppressing NF-kappaB translocation into the nucleus.	Curcumin	20-28	vascular cell adhesion molecule 1	Homo sapiens	186-192
31665675-4	2019	Our results show that combined curcumin (1 muM) and luteolin (0.5 muM) synergistically (combination index is 0.60) inhibited TNF-alpha-induced monocytes adhesion to human EA.hy926 endothelial cells while the individual chemicals did not have such effect at the selected concentrations.	Curcumin	31-39	tumor necrosis factor	Homo sapiens	125-134
31665675-5	2019	We also found that TNF-alpha-enhanced protein expressions of vascular cell adhesion molecule 1 (VCAM-1), monocyte chemotactic protein-1 (MCP-1) and nuclear factor (NF)-kappaB translocation were synergistically reduced by the combined curcumin and luteolin in EA.hy 926 cells while the individual chemical did not have this inhibitory effect.	Curcumin	234-242	tumor necrosis factor	Homo sapiens	19-28
31665675-5	2019	We also found that TNF-alpha-enhanced protein expressions of vascular cell adhesion molecule 1 (VCAM-1), monocyte chemotactic protein-1 (MCP-1) and nuclear factor (NF)-kappaB translocation were synergistically reduced by the combined curcumin and luteolin in EA.hy 926 cells while the individual chemical did not have this inhibitory effect.	Curcumin	234-242	vascular cell adhesion molecule 1	Homo sapiens	61-94
31736502-5	2019	However, because of its intense fluorescent activity, high-affinity, and specificity for Abeta, as well as structural similarities with traditional amyloid binding dyes, curcumin (Cur) is a promising candidate for labeling and imaging of Abeta plaques in postmortem brain tissue.	Curcumin	170-178	amyloid beta precursor protein	Homo sapiens	89-94
31736502-5	2019	However, because of its intense fluorescent activity, high-affinity, and specificity for Abeta, as well as structural similarities with traditional amyloid binding dyes, curcumin (Cur) is a promising candidate for labeling and imaging of Abeta plaques in postmortem brain tissue.	Curcumin	170-178	amyloid beta precursor protein	Homo sapiens	238-243
31736502-5	2019	However, because of its intense fluorescent activity, high-affinity, and specificity for Abeta, as well as structural similarities with traditional amyloid binding dyes, curcumin (Cur) is a promising candidate for labeling and imaging of Abeta plaques in postmortem brain tissue.	Curcumin	180-183	amyloid beta precursor protein	Homo sapiens	89-94
31736502-5	2019	However, because of its intense fluorescent activity, high-affinity, and specificity for Abeta, as well as structural similarities with traditional amyloid binding dyes, curcumin (Cur) is a promising candidate for labeling and imaging of Abeta plaques in postmortem brain tissue.	Curcumin	180-183	amyloid beta precursor protein	Homo sapiens	238-243
31432177-0	2019	Curcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR pathways.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	111-115
31432177-7	2019	Furthermore, curcumin significantly inhibited the expression of Toll-like receptor 4 (TLR4)/MyD88 and EGFR in a dose- and time-dependent manner.	Curcumin	13-21	epidermal growth factor receptor	Homo sapiens	102-106
31436299-0	2019	Curcumin decreases epithelial-mesenchymal transition by a Pirin-dependent mechanism in cervical cancer cells.	Curcumin	0-8	pirin	Homo sapiens	58-63
31432177-10	2019	These data suggested that curcumin may control the EGFR and TLR4/MyD88 pathways to synergistically downregulate downstream cell cycle- and EMT-related regulators, in order to block cell proliferation and metastasis in NSCLC.	Curcumin	26-34	epidermal growth factor receptor	Homo sapiens	51-55
31436299-10	2019	Furthermore, it was observed that PIR expression and Pirin protein levels were significantly decreased when SiHa cells were exposed to curcumin.	Curcumin	135-143	pirin	Homo sapiens	53-58
31436299-15	2019	These findings suggested that curcumin may decrease EMT, at least in part by a Pirin-dependent mechanism.	Curcumin	30-38	pirin	Homo sapiens	79-84
32239852-1	2019	OBJECTIVE: To study the mechanisms of curcumin alleviating oxidative stress and spleen apoptosis induced by overtraining in rats by regulating Kelch-like ECH-associated protein-1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) signaling pathway.	Curcumin	38-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	187-230
31436300-4	2019	Treatment with curcumin decreased the WT1 levels in K562 cells, and also decreased CCNA1 protein expression.	Curcumin	15-23	WT1 transcription factor	Homo sapiens	38-41
31436300-10	2019	Taken together, the data from the WT1 overexpression, and curcumin and mithramycin A treatment experiments, as well as those from chromatin binding assays, along with inferences from patient RNA analyses, establish a plausible link between WT1 and CCNA1, and support the functional significance of an elevated WT1 expression in leukemia, which may also affect CCNA1 expression.	Curcumin	58-66	WT1 transcription factor	Homo sapiens	34-37
31436300-10	2019	Taken together, the data from the WT1 overexpression, and curcumin and mithramycin A treatment experiments, as well as those from chromatin binding assays, along with inferences from patient RNA analyses, establish a plausible link between WT1 and CCNA1, and support the functional significance of an elevated WT1 expression in leukemia, which may also affect CCNA1 expression.	Curcumin	58-66	WT1 transcription factor	Homo sapiens	240-243
31436300-10	2019	Taken together, the data from the WT1 overexpression, and curcumin and mithramycin A treatment experiments, as well as those from chromatin binding assays, along with inferences from patient RNA analyses, establish a plausible link between WT1 and CCNA1, and support the functional significance of an elevated WT1 expression in leukemia, which may also affect CCNA1 expression.	Curcumin	58-66	WT1 transcription factor	Homo sapiens	240-243
31872665-11	2019	The results of Western blot assay showed that the expression levels of i NOS and e NOS were decreased significantly in the model group,while the expression levels of i NOS and e NOS were increased significantly in the positive control group and curcumin groups.	Curcumin	245-253	nitric oxide synthase 2	Rattus norvegicus	166-171
31872665-12	2019	The results indicated that curcumin had a certain protective effect on the aorta of rats with metabolic syndrome and improves the aortic endothelial dysfunction,and its mechanism may be related to the fact that curcumin could reduce the production of oxygen free radicals and up-regulate the expression of i NOS and e NOS in aorta.	Curcumin	27-35	nitric oxide synthase 2	Rattus norvegicus	306-311
31872665-12	2019	The results indicated that curcumin had a certain protective effect on the aorta of rats with metabolic syndrome and improves the aortic endothelial dysfunction,and its mechanism may be related to the fact that curcumin could reduce the production of oxygen free radicals and up-regulate the expression of i NOS and e NOS in aorta.	Curcumin	211-219	nitric oxide synthase 2	Rattus norvegicus	306-311
32239852-1	2019	OBJECTIVE: To study the mechanisms of curcumin alleviating oxidative stress and spleen apoptosis induced by overtraining in rats by regulating Kelch-like ECH-associated protein-1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) signaling pathway.	Curcumin	38-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	232-236
32239852-12	2019	Curcumin can up-regulate expression of Nrf2 and HO-1, alleviate oxidative stress induced by overtraining, enhance Bcl-2 expression and attenuate Bax expression, thereby inhibiting excessive spleen apoptosis of rats, protecting the structure and function of spleen.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	39-43
32239852-12	2019	Curcumin can up-regulate expression of Nrf2 and HO-1, alleviate oxidative stress induced by overtraining, enhance Bcl-2 expression and attenuate Bax expression, thereby inhibiting excessive spleen apoptosis of rats, protecting the structure and function of spleen.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	114-119
31595849-5	2019	Finally, the effect of Curcumin on the transcriptional efficiencies of miR-146a, nNOS, eNOS and iNOS was studied using luciferase assay.	Curcumin	23-31	nitric oxide synthase 3	Homo sapiens	87-91
31762817-0	2019	Lin28b is involved in curcumin-reversed paclitaxel chemoresistance and associated with poor prognosis in hepatocellular carcinoma.	Curcumin	22-30	lin-28 homolog B	Homo sapiens	0-6
31762817-4	2019	Curcumin, a natural anti-cancer agent, increased the sensitivity of HCC cells to paclitaxel through inhibiting NF-kappaB stimulated Lin28B expression both in vitro and in vivo.	Curcumin	0-8	lin-28 homolog B	Homo sapiens	132-138
32083122-0	2019	Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	18-21
32083122-6	2019	For molecular mechanism, curcumin reduced the mRNA expression levels of ERK2 and JUN genes and inhibited the phosphorylation of ERK and c-Jun.	Curcumin	25-33	mitogen-activated protein kinase 1	Homo sapiens	72-76
32083122-6	2019	For molecular mechanism, curcumin reduced the mRNA expression levels of ERK2 and JUN genes and inhibited the phosphorylation of ERK and c-Jun.	Curcumin	25-33	mitogen-activated protein kinase 1	Homo sapiens	72-75
32083122-7	2019	This suggests that curcumin inhibits the proliferation of endometrial carcinoma cells by downregulating ERK/c-Jun signaling pathway activity.	Curcumin	19-27	mitogen-activated protein kinase 1	Homo sapiens	104-107
32002054-0	2019	Curcumin"s Effect on COX-2 and IL-10 Serum in Preeclampsia"s Patient Undergo Sectio Caesarea with Spinal Anesthesia.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
32002054-2	2019	Curcumin affects several biological markers that are thought to play a role in the pathogenesis of preeclampsia such as IL-10 and COX-2, resulting in an improvement in pregnant women with preeclampsia.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
32002054-3	2019	AIM: To see the effect of perioperative curcumin administration on IL-10 and COX-2 in preeclamptic patients undergoing caesarean section under spinal anaesthesia.	Curcumin	40-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
31595849-5	2019	Finally, the effect of Curcumin on the transcriptional efficiencies of miR-146a, nNOS, eNOS and iNOS was studied using luciferase assay.	Curcumin	23-31	nitric oxide synthase 2	Homo sapiens	96-100
31595849-10	2019	Moreover, Curcumin enhanced miR-146a expression, while reducing the expression of nNOS, iNOS, cGPM, caspase-3 and PKG as well as the synthesis of NO.	Curcumin	10-18	nitric oxide synthase 2	Homo sapiens	88-92
31595849-10	2019	Moreover, Curcumin enhanced miR-146a expression, while reducing the expression of nNOS, iNOS, cGPM, caspase-3 and PKG as well as the synthesis of NO.	Curcumin	10-18	caspase 3	Homo sapiens	100-109
31595849-11	2019	Curcumin may exert its effect by reducing the transcriptional efficiency of iNOS promoter, while increasing the transcriptional efficiency of miR-146a promoter.	Curcumin	0-8	nitric oxide synthase 2	Homo sapiens	76-80
31734652-15	2019	NaHS caused more limitation of inflammation than leptin and curcumin by affecting iNOS.	Curcumin	60-68	nitric oxide synthase 2	Rattus norvegicus	82-86
31581661-9	2019	TGF-beta signaling, including the androgen/TGF-beta inhibitor Prostate transmembrane protein androgen-induced 1 (PMEPA1), was the only pathway impacted by curcumin treatment after 48 h. Our findings also established that MYC Proto-Oncogene, basic helix-loop-helix (bHLH) Transcription Factor (MYC) signaling was down-regulated in curcumin-treated cell lines.	Curcumin	155-163	prostate transmembrane protein, androgen induced 1	Homo sapiens	62-111
31581661-9	2019	TGF-beta signaling, including the androgen/TGF-beta inhibitor Prostate transmembrane protein androgen-induced 1 (PMEPA1), was the only pathway impacted by curcumin treatment after 48 h. Our findings also established that MYC Proto-Oncogene, basic helix-loop-helix (bHLH) Transcription Factor (MYC) signaling was down-regulated in curcumin-treated cell lines.	Curcumin	155-163	prostate transmembrane protein, androgen induced 1	Homo sapiens	113-119
31581661-9	2019	TGF-beta signaling, including the androgen/TGF-beta inhibitor Prostate transmembrane protein androgen-induced 1 (PMEPA1), was the only pathway impacted by curcumin treatment after 48 h. Our findings also established that MYC Proto-Oncogene, basic helix-loop-helix (bHLH) Transcription Factor (MYC) signaling was down-regulated in curcumin-treated cell lines.	Curcumin	330-338	prostate transmembrane protein, androgen induced 1	Homo sapiens	113-119
31456905-9	2019	Curcumin, a nonspecific activator of CFTR, further increased PDT-enhanced cell migration, whereas inhibition of CFTR and FAK delayed cell migration.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	37-41
31369746-6	2019	Furthermore, pretreatment with E100 (10 mg/kg) the increased microglial activation, proinflammatory cytokines and expression of NF-kappaB, iNOS, and COX-2 in the cerebellum as well as the hippocampus (all P &lt; 0.05).	Curcumin	31-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	128-137
31369746-6	2019	Furthermore, pretreatment with E100 (10 mg/kg) the increased microglial activation, proinflammatory cytokines and expression of NF-kappaB, iNOS, and COX-2 in the cerebellum as well as the hippocampus (all P &lt; 0.05).	Curcumin	31-35	nitric oxide synthase 2, inducible	Mus musculus	139-143
31612395-0	2019	Curcumin Recovers Intracellular Lipid Droplet Formation Through Increasing Perilipin 5 Gene Expression in Activated Hepatic Stellate Cells In Vitro.	Curcumin	0-8	perilipin 5	Homo sapiens	75-86
31612395-7	2019	Perilipin 5 siRNA eliminated curcumin-induced LD formation in HSCs.	Curcumin	29-37	perilipin 5	Homo sapiens	0-11
31612395-8	2019	These results suggest that curcumin recovers LD formation and lipid accumulation in activated HSCs by increasing perilipin 5 gene expression.	Curcumin	27-35	perilipin 5	Homo sapiens	113-124
31612395-9	2019	Furthermore, inhibition of AMPK or PPARgamma activity blocked curcumin"s effect on Plin5 gene expression and LD formation.	Curcumin	62-70	peroxisome proliferator activated receptor gamma	Homo sapiens	35-44
31612395-9	2019	Furthermore, inhibition of AMPK or PPARgamma activity blocked curcumin"s effect on Plin5 gene expression and LD formation.	Curcumin	62-70	perilipin 5	Homo sapiens	83-88
31687403-7	2019	Curcumin induced the cycle arrest of the HONE1 and HK1-EBV cells positive for EBV.	Curcumin	0-8	hexokinase 1	Homo sapiens	51-54
31687403-9	2019	Furthermore, curcumin decreased the expression of EBNA1 in the HONE1 and HK1-EBV cells and inhibited the transcriptional level of EBNA1 in the HeLa cells.	Curcumin	13-21	hexokinase 1	Homo sapiens	73-76
31687403-11	2019	In addition, curcumin inhibited the proliferation of HONE1 and HK1-EBV cells positive for EBV, probably by decreasing the expression level of EBNA1.	Curcumin	13-21	hexokinase 1	Homo sapiens	63-66
31687403-12	2019	In both the HONE1 and HK1-EBV cells, curcumin inhibited the EBV latent and lytic replication.	Curcumin	37-45	hexokinase 1	Homo sapiens	22-25
31470039-9	2019	GLP-1 secretion induced by curcumin and its oxidative degradation products was associated with activation of PKC, ERK, and CaM kinase II.	Curcumin	27-35	mitogen-activated protein kinase 1	Mus musculus	114-117
31486959-0	2019	Curcumin and capsaicin modulates LPS induced expression of COX-2, IL-6 and TGF-beta in human peripheral blood mononuclear cells.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
31486959-0	2019	Curcumin and capsaicin modulates LPS induced expression of COX-2, IL-6 and TGF-beta in human peripheral blood mononuclear cells.	Curcumin	0-8	interleukin 6	Homo sapiens	66-70
31486959-0	2019	Curcumin and capsaicin modulates LPS induced expression of COX-2, IL-6 and TGF-beta in human peripheral blood mononuclear cells.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	75-83
31486959-2	2019	RT-PCR analysis has shown that the curcumin and capsaicin significantly reduced LPS induced over expression of COX-2, IL-6 and TGF-beta in PBMCs.	Curcumin	35-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
31486959-2	2019	RT-PCR analysis has shown that the curcumin and capsaicin significantly reduced LPS induced over expression of COX-2, IL-6 and TGF-beta in PBMCs.	Curcumin	35-43	interleukin 6	Homo sapiens	118-122
31486959-2	2019	RT-PCR analysis has shown that the curcumin and capsaicin significantly reduced LPS induced over expression of COX-2, IL-6 and TGF-beta in PBMCs.	Curcumin	35-43	transforming growth factor beta 1	Homo sapiens	127-135
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Curcumin	24-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Curcumin	24-32	interleukin 6	Homo sapiens	79-83
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Curcumin	24-32	transforming growth factor beta 1	Homo sapiens	88-96
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Curcumin	161-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Curcumin	161-169	interleukin 6	Homo sapiens	79-83
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Curcumin	161-169	transforming growth factor beta 1	Homo sapiens	88-96
31593984-5	2019	Results: Treatment with curcumin resulted in a dose- and time-dependent decrease in IL-1beta-induced synthesis of inflammatory cytokines, including IL-6, IL-8, MCP-1, and ICAM-1 at both mRNA and protein levels.	Curcumin	24-32	interleukin 6	Homo sapiens	148-152
31236854-0	2019	MicroRNA-1246 regulates the radio-sensitizing effect of curcumin in bladder cancer cells via activating P53.	Curcumin	56-64	tumor protein p53	Homo sapiens	104-107
31696502-18	2019	After treatment with curcumin, the expression of Bcl-2 was decreased and that of Bax and active caspase-3 was increased.	Curcumin	21-29	BCL2 apoptosis regulator	Homo sapiens	49-54
31696502-18	2019	After treatment with curcumin, the expression of Bcl-2 was decreased and that of Bax and active caspase-3 was increased.	Curcumin	21-29	BCL2 associated X, apoptosis regulator	Homo sapiens	81-84
31696502-18	2019	After treatment with curcumin, the expression of Bcl-2 was decreased and that of Bax and active caspase-3 was increased.	Curcumin	21-29	caspase 3	Homo sapiens	96-105
32802100-11	2019	In addition, the spinal concentration of TNF-alpha and IL-6 was reduced by curcumin (2.5, 5, and 10 mg/kg) significantly.	Curcumin	75-83	tumor necrosis factor	Rattus norvegicus	41-50
31236854-12	2019	CONCLUSION: miR-1246 is involved in the anti-cancer effects of curcumin and irradiation through targeting the inhibition of p53 gene translation in bladder cancer cells.	Curcumin	63-71	tumor protein p53	Homo sapiens	124-127
32802100-11	2019	In addition, the spinal concentration of TNF-alpha and IL-6 was reduced by curcumin (2.5, 5, and 10 mg/kg) significantly.	Curcumin	75-83	interleukin 6	Rattus norvegicus	55-59
31593984-5	2019	Results: Treatment with curcumin resulted in a dose- and time-dependent decrease in IL-1beta-induced synthesis of inflammatory cytokines, including IL-6, IL-8, MCP-1, and ICAM-1 at both mRNA and protein levels.	Curcumin	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	154-158
31593984-6	2019	Decrease in lipid droplets and expression of PPARgamma and c/EBPalpha/beta were noted in fibroblasts treated with curcumin during adipose differentiation.	Curcumin	114-122	peroxisome proliferator activated receptor gamma	Homo sapiens	45-54
31593984-6	2019	Decrease in lipid droplets and expression of PPARgamma and c/EBPalpha/beta were noted in fibroblasts treated with curcumin during adipose differentiation.	Curcumin	114-122	CCAAT enhancer binding protein alpha	Homo sapiens	59-74
31593984-8	2019	Curcumin significantly suppressed IL-1beta-induced phosphorylated extracellular signal-regulated kinase, Akt, c-Jun NH(2)-terminal kinase, and nuclear factor kappa-light-chain-enhancer of activated B cells, p65 proteins and stimulated beta-catenin translocation into nucleus during adipogenesis.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	105-108
31510839-0	2019	Curcumin ameliorates chronic obstructive pulmonary disease by modulating autophagy and endoplasmic reticulum stress through regulation of SIRT1 in a rat model.	Curcumin	0-8	sirtuin 1	Rattus norvegicus	138-143
30983042-8	2019	In the overall analyses, curcumin led to significant decreases in fasting blood glucose (FBG), glycated haemoglobin (HbA1c) and homeostatic model assessment of insulin resistance (HOMA-IR).	Curcumin	25-33	insulin	Homo sapiens	160-167
31432122-10	2019	Serum expression levels of TNF-alpha and CRP were reduced by curcumin.	Curcumin	61-69	tumor necrosis factor	Rattus norvegicus	27-36
31432122-10	2019	Serum expression levels of TNF-alpha and CRP were reduced by curcumin.	Curcumin	61-69	C-reactive protein	Rattus norvegicus	41-44
31454128-0	2019	Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro-inflammatory cytokines and Nrf2/Ho-1 pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	168-172
31473513-0	2019	Curcumin attenuates migration of vascular smooth muscle cells via inhibiting NFkappaB-mediated NLRP3 expression in spontaneously hypertensive rats.	Curcumin	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	95-100
31473513-7	2019	Curcumin attenuated VSMC migration, inhibited nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) expression and reduced interleukin (IL)-1beta concentration in VSMC of SHR, which were similar to the effects of NLRP3 knockdown on IL-1beta concentration and VSMC migration.	Curcumin	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	46-111
31473513-7	2019	Curcumin attenuated VSMC migration, inhibited nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) expression and reduced interleukin (IL)-1beta concentration in VSMC of SHR, which were similar to the effects of NLRP3 knockdown on IL-1beta concentration and VSMC migration.	Curcumin	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	113-118
31473513-7	2019	Curcumin attenuated VSMC migration, inhibited nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) expression and reduced interleukin (IL)-1beta concentration in VSMC of SHR, which were similar to the effects of NLRP3 knockdown on IL-1beta concentration and VSMC migration.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	143-165
31473513-7	2019	Curcumin attenuated VSMC migration, inhibited nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) expression and reduced interleukin (IL)-1beta concentration in VSMC of SHR, which were similar to the effects of NLRP3 knockdown on IL-1beta concentration and VSMC migration.	Curcumin	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	233-238
31473513-7	2019	Curcumin attenuated VSMC migration, inhibited nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) expression and reduced interleukin (IL)-1beta concentration in VSMC of SHR, which were similar to the effects of NLRP3 knockdown on IL-1beta concentration and VSMC migration.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	252-260
31473513-9	2019	In another in vitro model of rat VSMC migration, curcumin also inhibited angiotensin II-induced VSMC migration, NFkappaB activation, NLRP3 expression and IL-1beta production.	Curcumin	49-57	angiotensinogen	Rattus norvegicus	73-87
31473513-9	2019	In another in vitro model of rat VSMC migration, curcumin also inhibited angiotensin II-induced VSMC migration, NFkappaB activation, NLRP3 expression and IL-1beta production.	Curcumin	49-57	NLR family, pyrin domain containing 3	Rattus norvegicus	133-138
31473513-9	2019	In another in vitro model of rat VSMC migration, curcumin also inhibited angiotensin II-induced VSMC migration, NFkappaB activation, NLRP3 expression and IL-1beta production.	Curcumin	49-57	interleukin 1 beta	Rattus norvegicus	154-162
31473513-10	2019	Intragastric administration of curcumin in SHR attenuated hypertension and reduced NFkappaB activation, NLRP3 and matrix metalloproteinase-9 expressions and aortic media thickness.	Curcumin	31-39	NLR family, pyrin domain containing 3	Rattus norvegicus	104-109
31473513-11	2019	These results indicate that curcumin inhibits VSMC migration via inhibiting NFkappaB-mediated NLRP3 expression in VSMC of SHR or in angiotensin II-treated VSMC.	Curcumin	28-36	NLR family, pyrin domain containing 3	Rattus norvegicus	94-99
31473513-11	2019	These results indicate that curcumin inhibits VSMC migration via inhibiting NFkappaB-mediated NLRP3 expression in VSMC of SHR or in angiotensin II-treated VSMC.	Curcumin	28-36	angiotensinogen	Rattus norvegicus	132-146
31301288-0	2019	Synergistic inhibition of catalase activity by food colorants sunset yellow and curcumin: An experimental and MLSD simulation approach.	Curcumin	80-88	catalase	Homo sapiens	26-34
31569380-10	2019	A non-cytotoxic dose of curcumin (15 microM) inhibited MCE, downregulated the expression of PPARgamma and C/EBPalpha, prevented differentiation medium-induced beta-catenin downregulation, and decreased the lipid accumulation in 3T3-L1 adipocytes.	Curcumin	24-32	peroxisome proliferator activated receptor gamma	Homo sapiens	92-101
31569380-10	2019	A non-cytotoxic dose of curcumin (15 microM) inhibited MCE, downregulated the expression of PPARgamma and C/EBPalpha, prevented differentiation medium-induced beta-catenin downregulation, and decreased the lipid accumulation in 3T3-L1 adipocytes.	Curcumin	24-32	CCAAT enhancer binding protein alpha	Homo sapiens	106-116
31662771-0	2019	SOD2 Mediates Curcumin-Induced Protection against Oxygen-Glucose Deprivation/Reoxygenation Injury in HT22 Cells.	Curcumin	14-22	superoxide dismutase 2, mitochondrial	Mus musculus	0-4
31662771-2	2019	The aim of this study is to explore the potential neuroprotective mechanism of curcumin against oxygen-glucose deprivation/reoxygenation (OGD/R) injury in HT22 cells and investigate whether type-2 superoxide dismutase (SOD2) is involved in the curcumin-induced protection.	Curcumin	79-87	superoxide dismutase 2, mitochondrial	Mus musculus	219-223
31662771-5	2019	Meanwhile, coadministration of 100 ng/ml curcumin reduced the cell injury and apoptosis, inhibited intracellular ROS and mitochondrial superoxide accumulation, and ameliorated intracellular SOD2, cell morphology, MMP, and mitochondrial complex I activity.	Curcumin	41-49	superoxide dismutase 2, mitochondrial	Mus musculus	190-194
31662771-6	2019	Downregulating the SOD2 expression by using siRNA, however, significantly reversed the curcumin-induced cytoprotection (P &lt; 0.05).	Curcumin	87-95	superoxide dismutase 2, mitochondrial	Mus musculus	19-23
31301288-3	2019	It is previously shown that curcumin enhances the catalase activity by affecting its structural pocket in the active site.	Curcumin	28-36	catalase	Homo sapiens	50-58
31301288-4	2019	The aim of this study was to investigate the combination effects of food colorants sunset yellow FCF (SNY) and curcumin on the activation and/or inactivation of catalase activity using multispectral (fluorescence, FTIR, and UV-vis) analysis and simultaneous docking simulations.	Curcumin	111-119	catalase	Homo sapiens	161-169
31301288-8	2019	Molecular dynamic simulation data indicated that the curcumin binding to the cavity, in the middle of the catalase helical domain, facilitates SNY binding to the enzyme pocket.	Curcumin	53-61	catalase	Homo sapiens	106-114
31301288-11	2019	However, curcumin could make the complex more stable enhancing the SNY inhibition of catalase activity.	Curcumin	9-17	catalase	Homo sapiens	85-93
31369762-4	2019	MATERIALS AND METHODS: Curcumin was bound to bovine serum albumin and its photophysical properties was studied as well as its effect on cell viability after light exposure through MTT assay and confocal imaging.	Curcumin	23-31	albumin	Homo sapiens	52-65
31103163-1	2019	Herein, we introduce a nanopaper-based analytical device (NAD) or "lab-on-nanopaper" device for visual sensing of human serum albumin (HSA) in human blood serums, which relies on embedding of curcumin within transparent bacterial cellulose (BC) nanopaper.	Curcumin	192-200	albumin	Homo sapiens	120-133
31103163-4	2019	The color changes of curcumin embedded in BC nanopaper (CEBC) due to the inhibitory effect of HSA on the curcumin degradation in alkaline solutions, which can be monitored visually (naked eye/Smartphone camera) or spectroscopically using a spectrophotometer, were linearly proportional to the HSA concentration in the range of 10-300 muM and 25-400 muM, respectively.	Curcumin	21-29	latexin	Homo sapiens	334-337
31103163-4	2019	The color changes of curcumin embedded in BC nanopaper (CEBC) due to the inhibitory effect of HSA on the curcumin degradation in alkaline solutions, which can be monitored visually (naked eye/Smartphone camera) or spectroscopically using a spectrophotometer, were linearly proportional to the HSA concentration in the range of 10-300 muM and 25-400 muM, respectively.	Curcumin	21-29	latexin	Homo sapiens	349-352
31103163-4	2019	The color changes of curcumin embedded in BC nanopaper (CEBC) due to the inhibitory effect of HSA on the curcumin degradation in alkaline solutions, which can be monitored visually (naked eye/Smartphone camera) or spectroscopically using a spectrophotometer, were linearly proportional to the HSA concentration in the range of 10-300 muM and 25-400 muM, respectively.	Curcumin	105-113	latexin	Homo sapiens	334-337
31103163-4	2019	The color changes of curcumin embedded in BC nanopaper (CEBC) due to the inhibitory effect of HSA on the curcumin degradation in alkaline solutions, which can be monitored visually (naked eye/Smartphone camera) or spectroscopically using a spectrophotometer, were linearly proportional to the HSA concentration in the range of 10-300 muM and 25-400 muM, respectively.	Curcumin	105-113	latexin	Homo sapiens	349-352
31557970-6	2019	The exposure of neuroblastoma cells to curcumin induced: (a) up-regulation of GOLPH3+ cells; (b) augmentation of double-strand breaks; (c) Golgi fragmentation and dispersal throughout the cytoplasm; (d) increase of apoptosis and autophagy; (e) increased expression of TPX2 oncoprotein, able to repair DNA damage.	Curcumin	39-47	golgi phosphoprotein 3	Homo sapiens	78-84
31514267-0	2019	The Therapeutic Effect of Curcumin in Quinolinic Acid-Induced Neurotoxicity in Rats is Associated with BDNF, ERK1/2, Nrf2, and Antioxidant Enzymes.	Curcumin	26-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	117-121
31488728-5	2019	Curcumin treatment significantly increased the expression of Beclin1, Atg5, and Atg16L1, induced the formation of autophagosomes, and promoted autophagosome-lysosome fusion in N2a/APP695swe cells.	Curcumin	0-8	autophagy related 16-like 1 (S. cerevisiae)	Mus musculus	80-87
31369762-5	2019	KEY FINDINGS: Bovine serum albumin binds curcumin with moderate affinity and solubilizes the hydrophobic compound preserving its photophysical properties for several hours.	Curcumin	41-49	albumin	Homo sapiens	21-34
31369762-6	2019	Cell viability assays demonstrate that when bound to serum albumin, curcumin is an effective photosensitizer for HeLa cells, with better performance than curcumin alone.	Curcumin	68-76	albumin	Homo sapiens	53-66
31369762-6	2019	Cell viability assays demonstrate that when bound to serum albumin, curcumin is an effective photosensitizer for HeLa cells, with better performance than curcumin alone.	Curcumin	154-162	albumin	Homo sapiens	53-66
31369762-7	2019	Confocal fluorescence imaging reveals that when curcumin is delivered alone, it preferentially associates with mitochondria, whereas curcumin bound to bovine serum albumin is found in additional locations within the cell, a fact that may be related to the higher phototoxicity observed in this case.	Curcumin	133-141	albumin	Homo sapiens	158-171
31369762-8	2019	SIGNIFICANCE: The higher bioavailability of the photosensitizing compound curcumin when bound to serum albumin may be exploited to increase the efficiency of the drug in photodynamic therapy of tumors.	Curcumin	74-82	albumin	Homo sapiens	97-110
31136038-4	2019	Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer.	Curcumin	0-8	DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1	Homo sapiens	79-84
31564949-0	2019	Effect of curcumin on gene expression and protein level of methionine sulfoxide reductase A (MSRA), SOD, CAT and GPx in Freund"s adjuvant inflammation-induced male rats.	Curcumin	10-18	methionine sulfoxide reductase A	Rattus norvegicus	59-91
31564949-0	2019	Effect of curcumin on gene expression and protein level of methionine sulfoxide reductase A (MSRA), SOD, CAT and GPx in Freund"s adjuvant inflammation-induced male rats.	Curcumin	10-18	methionine sulfoxide reductase A	Rattus norvegicus	93-97
31564949-10	2019	These results also illustrated that the gene expression and protein level of MSRA in groups treated with curcumin increased significantly (p&lt;=0.05).	Curcumin	105-113	methionine sulfoxide reductase A	Rattus norvegicus	77-81
31564949-12	2019	The increasing level of MSRA can be due to the antioxidant effect of curcumin.	Curcumin	69-77	methionine sulfoxide reductase A	Rattus norvegicus	24-28
31480567-6	2019	Interestingly, there is also a gradual increase in the occurrence of terms related to diseases or to natural compounds, the most prominent being sulforaphane, curcumin, and resveratrol that modulate the Nrf2 pathway.	Curcumin	159-167	NFE2 like bZIP transcription factor 2	Homo sapiens	203-207
31491967-6	2019	In the current study, we predicted the interaction potential of the natural compounds vincamine, ajmalicine and emetine with the Abeta peptide concerned in the treatment of AD against the standard control, curcumin, to validate the Abeta peptide-compounds results.	Curcumin	206-214	amyloid beta precursor protein	Homo sapiens	129-134
31405268-5	2019	When A172 cells were incubated with 10 muM curcumin, autophagy increased in a time-dependent manner.	Curcumin	43-51	latexin	Homo sapiens	39-42
31516856-0	2019	Curcumin effects on myeloperoxidase, interleukin-18 and matrix metalloproteinase-9 inflammatory biomarkers in patients with unstable angina: A randomized clinical trial.	Curcumin	0-8	myeloperoxidase	Homo sapiens	20-35
31326241-2	2019	Hispolon size, smaller than curcumin, fits better than curcumin into the active site of HDAC6, an enzyme involved in deacetylation of lysine residues.	Curcumin	28-36	histone deacetylase 6	Homo sapiens	88-93
31326241-2	2019	Hispolon size, smaller than curcumin, fits better than curcumin into the active site of HDAC6, an enzyme involved in deacetylation of lysine residues.	Curcumin	55-63	histone deacetylase 6	Homo sapiens	88-93
31405268-9	2019	Cell death was decreased by inhibiting curcumin-induced autophagy using small interference RNA (siRNA) of Atg5 or Beclin1.	Curcumin	39-47	autophagy related 5	Homo sapiens	106-110
31074052-0	2019	Curcumin increased the expression of c-FLIP in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients.	Curcumin	0-8	CASP8 and FADD like apoptosis regulator	Homo sapiens	37-43
31592057-5	2019	Curcumin activated the protein expression of molecular chaperones, such as heat shock protein (HSP)40 and HSP70.	Curcumin	0-8	DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1	Homo sapiens	75-101
31411571-7	2019	Males that received curcumin with or without fructose during suckling and weaned onto a high-fructose diet had lower (p &lt;= 0.05, ANOVA) osteocalcin concentration versus the other males.	Curcumin	20-28	bone gamma-carboxyglutamate protein	Rattus norvegicus	139-150
31411571-8	2019	Similarly, in females rats, curcumin alone or administered with fructose resulted in lower (p &lt;= 0.05, ANOVA) osteocalcin concentration versus female rats administered the vehicle control.	Curcumin	28-36	bone gamma-carboxyglutamate protein	Rattus norvegicus	113-124
31411571-9	2019	Neonatal curcumin-induced decrease in plasma total osteocalcin concentration may predispose to adverse consequences on glucose metabolism and bone health.	Curcumin	9-17	bone gamma-carboxyglutamate protein	Rattus norvegicus	51-62
31042325-4	2019	In the present study, we showed that curcumin altered the expression of cell cycle-related genes (cyclin D1, PCNA, and p21) and inhibited the proliferation of prostate cancer cells.	Curcumin	37-45	cyclin dependent kinase inhibitor 1A	Homo sapiens	119-122
31074052-0	2019	Curcumin increased the expression of c-FLIP in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients.	Curcumin	0-8	thrombospondin 1	Homo sapiens	110-113
31074052-3	2019	It has been shown that curcumin exhibits modulatory effects on apoptosis and cytotoxicity-related molecules in HAM/TSP patients.	Curcumin	23-31	thrombospondin 1	Homo sapiens	115-118
31074052-4	2019	In the present study, we examined the effect of curcumin on the gene expression of caspase-8, caspase-10, and anti-apoptotic protein c-FLIP, in HAM/TSP patients.	Curcumin	48-56	CASP8 and FADD like apoptosis regulator	Homo sapiens	133-139
31074052-4	2019	In the present study, we examined the effect of curcumin on the gene expression of caspase-8, caspase-10, and anti-apoptotic protein c-FLIP, in HAM/TSP patients.	Curcumin	48-56	thrombospondin 1	Homo sapiens	148-151
31074052-8	2019	The mRNA expression of c-FLIPL and c-FLIPs was higher after curcumin treatment compared with before treatment and significant differences were observed between the two groups (P = 0.004 and P = 0.044, respectively).	Curcumin	60-68	CASP8 and FADD like apoptosis regulator	Homo sapiens	23-30
31074052-8	2019	The mRNA expression of c-FLIPL and c-FLIPs was higher after curcumin treatment compared with before treatment and significant differences were observed between the two groups (P = 0.004 and P = 0.044, respectively).	Curcumin	60-68	CASP8 and FADD like apoptosis regulator	Homo sapiens	35-42
31074052-10	2019	In conclusion, our results showed that curcumin increased the expression of c-FLIP in HAM/TSP patients which might suggest that, this molecule is involved in the apoptosis of HTLV-1-infected cells.	Curcumin	39-47	CASP8 and FADD like apoptosis regulator	Homo sapiens	76-82
31074052-10	2019	In conclusion, our results showed that curcumin increased the expression of c-FLIP in HAM/TSP patients which might suggest that, this molecule is involved in the apoptosis of HTLV-1-infected cells.	Curcumin	39-47	thrombospondin 1	Homo sapiens	90-93
31330227-0	2019	Curcumin protects against methylmercury-induced cytotoxicity in primary rat astrocytes by activating the Nrf2/ARE pathway independently of PKCdelta.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	105-109
30869142-6	2019	There was a linear (P &lt; 0.001) effect of dietary curcumin on relative abundance of SOD1, GPX1, CAT, HO-1, and Nrf2 transcripts, and a quadratic (P &lt; 0.001) increase in the activities of GSH-Px and T-AOC in jejunal mucosa.	Curcumin	52-60	glutathione peroxidase 1	Anas platyrhynchos	92-96
30869142-6	2019	There was a linear (P &lt; 0.001) effect of dietary curcumin on relative abundance of SOD1, GPX1, CAT, HO-1, and Nrf2 transcripts, and a quadratic (P &lt; 0.001) increase in the activities of GSH-Px and T-AOC in jejunal mucosa.	Curcumin	52-60	catalase	Anas platyrhynchos	98-101
31480578-5	2019	The Curcumin ASD demonstrated enhanced bioavailability by 11-fold and improved anti-inflammatory activities by the decrease in cytokine production (MMP-9, IL-1beta, IL-6, VEGF, MIP-2, and TNF-alpha) compared to the raw Curcumin.	Curcumin	4-12	interleukin 1 beta	Homo sapiens	155-163
31480578-5	2019	The Curcumin ASD demonstrated enhanced bioavailability by 11-fold and improved anti-inflammatory activities by the decrease in cytokine production (MMP-9, IL-1beta, IL-6, VEGF, MIP-2, and TNF-alpha) compared to the raw Curcumin.	Curcumin	4-12	interleukin 6	Homo sapiens	165-169
31480578-5	2019	The Curcumin ASD demonstrated enhanced bioavailability by 11-fold and improved anti-inflammatory activities by the decrease in cytokine production (MMP-9, IL-1beta, IL-6, VEGF, MIP-2, and TNF-alpha) compared to the raw Curcumin.	Curcumin	4-12	vascular endothelial growth factor A	Homo sapiens	171-175
31480578-5	2019	The Curcumin ASD demonstrated enhanced bioavailability by 11-fold and improved anti-inflammatory activities by the decrease in cytokine production (MMP-9, IL-1beta, IL-6, VEGF, MIP-2, and TNF-alpha) compared to the raw Curcumin.	Curcumin	4-12	tumor necrosis factor	Homo sapiens	188-197
31330227-6	2019	Moreover, curcumin pretreatment increased Nrf2 nuclear translocation and downstream enzyme expression, heme oxygenase-1 (HO-1) and NADPH quinone reductase-1 (NQO1).	Curcumin	10-18	NFE2 like bZIP transcription factor 2	Rattus norvegicus	42-46
31330227-6	2019	Moreover, curcumin pretreatment increased Nrf2 nuclear translocation and downstream enzyme expression, heme oxygenase-1 (HO-1) and NADPH quinone reductase-1 (NQO1).	Curcumin	10-18	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	131-156
31330227-5	2019	Curcumin (2, 5, 10 or 20 muM) pretreatment for 12 h significantly ameliorated the MeHg-induced astrocyte injury and oxidative stress, as evidenced by morphological alterations, lactate dehydrogenase (LDH) release, reactive oxygen species (ROS) generation, and glutathione (GSH) and catalase (CAT) levels.	Curcumin	0-8	catalase	Rattus norvegicus	282-290
31330227-6	2019	Moreover, curcumin pretreatment increased Nrf2 nuclear translocation and downstream enzyme expression, heme oxygenase-1 (HO-1) and NADPH quinone reductase-1 (NQO1).	Curcumin	10-18	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	158-162
31330227-7	2019	Knockdown of Nrf2 with siRNA attenuated the protective effect of curcumin against MeHg-induced cell death.	Curcumin	65-73	NFE2 like bZIP transcription factor 2	Rattus norvegicus	13-17
31330227-9	2019	Taken together, these findings confirm that curcumin protects against MeHg-induced neurotoxicity by activating the Nrf2/ARE pathway and this protection is independent of PKCdelta activation.	Curcumin	44-52	NFE2 like bZIP transcription factor 2	Rattus norvegicus	115-119
31330227-5	2019	Curcumin (2, 5, 10 or 20 muM) pretreatment for 12 h significantly ameliorated the MeHg-induced astrocyte injury and oxidative stress, as evidenced by morphological alterations, lactate dehydrogenase (LDH) release, reactive oxygen species (ROS) generation, and glutathione (GSH) and catalase (CAT) levels.	Curcumin	0-8	catalase	Rattus norvegicus	292-295
31511210-6	2019	In the two glioma cell lines, curcumin significantly suppressed the invasion and migration of the cells (P &amp;lt; 0.05) and lowered the expressions of hepatoma-derived growth factor (HDGF), Ncadherin, vimentin, Snail and Slug, but increased the expression of E-cadherin.	Curcumin	30-38	snail family transcriptional repressor 1	Homo sapiens	213-218
31472681-12	2019	Curcumin (20 muM) significantly suppressed PA- or TG-induced decrease in cell viability, caspase 3 activity, and the expression levels of BAX, CHOP, and GRP78.	Curcumin	0-8	heat shock protein 5	Mus musculus	153-158
31511210-6	2019	In the two glioma cell lines, curcumin significantly suppressed the invasion and migration of the cells (P &amp;lt; 0.05) and lowered the expressions of hepatoma-derived growth factor (HDGF), Ncadherin, vimentin, Snail and Slug, but increased the expression of E-cadherin.	Curcumin	30-38	cadherin 1	Homo sapiens	261-271
31455356-7	2019	RESULTS: Curcumin treatment markedly inhibited the degradation of IkappaBalpha, the activation of NF-kappaB signaling pathway, and the expression levels of the NF-kappaB downstream inflammatory genes such as IL-1beta, IL-6, TNF-alpha, COX-2, and PGE2 in the MSU-stimulated THP-1-derived macrophages.	Curcumin	9-17	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	66-78
31455356-0	2019	Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IkappaBalpha and blocking mitochondrial damage.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	86-98
31455356-7	2019	RESULTS: Curcumin treatment markedly inhibited the degradation of IkappaBalpha, the activation of NF-kappaB signaling pathway, and the expression levels of the NF-kappaB downstream inflammatory genes such as IL-1beta, IL-6, TNF-alpha, COX-2, and PGE2 in the MSU-stimulated THP-1-derived macrophages.	Curcumin	9-17	interleukin 1 beta	Mus musculus	208-216
31455356-7	2019	RESULTS: Curcumin treatment markedly inhibited the degradation of IkappaBalpha, the activation of NF-kappaB signaling pathway, and the expression levels of the NF-kappaB downstream inflammatory genes such as IL-1beta, IL-6, TNF-alpha, COX-2, and PGE2 in the MSU-stimulated THP-1-derived macrophages.	Curcumin	9-17	interleukin 6	Mus musculus	218-222
31455356-7	2019	RESULTS: Curcumin treatment markedly inhibited the degradation of IkappaBalpha, the activation of NF-kappaB signaling pathway, and the expression levels of the NF-kappaB downstream inflammatory genes such as IL-1beta, IL-6, TNF-alpha, COX-2, and PGE2 in the MSU-stimulated THP-1-derived macrophages.	Curcumin	9-17	tumor necrosis factor	Mus musculus	224-233
31455356-7	2019	RESULTS: Curcumin treatment markedly inhibited the degradation of IkappaBalpha, the activation of NF-kappaB signaling pathway, and the expression levels of the NF-kappaB downstream inflammatory genes such as IL-1beta, IL-6, TNF-alpha, COX-2, and PGE2 in the MSU-stimulated THP-1-derived macrophages.	Curcumin	9-17	GLI family zinc finger 2	Homo sapiens	273-278
31455356-8	2019	Curcumin administration protected THP-1 and RAW264.7 cells from MSU induced mitochondrial damage through preventing mitochondrial membrane potential reduction, decreasing mitochondria ROS, and then inhibited the activity of NLRP3 inflammasome.	Curcumin	0-8	GLI family zinc finger 2	Homo sapiens	34-39
31455356-11	2019	CONCLUSION: Curcumin administration effectively alleviated MSU-induced inflammation by suppressing the degradation of IkappaBalpha, the activation NF-kappaB signaling pathway, the damage of mitochondria, and the activity of NLRP3 inflammasome.	Curcumin	12-20	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	118-130
31485503-9	2019	curcumin 50 mg/kg BW 1 hour before L-Arg injection and then once daily for 3 days.	Curcumin	0-8	body weight QTL 1	Mus musculus	18-22
31485503-11	2019	curcumin 200 mg/kg BW 1 hour before L-Arg injection and then once daily for 3 days.	Curcumin	0-8	body weight QTL 1	Mus musculus	19-23
31507403-7	2019	Of the four compounds screened, only curcumin (-9.6 kcal/mol) and piperine (-10.5 kcal/mol) showed favorable binding affinities and interactions towards AChE and were hence selected.	Curcumin	37-45	acetylcholinesterase (Cartwright blood group)	Homo sapiens	153-157
31507403-8	2019	In vitro AChE inhibition demonstrated that combination of curcumin and piperine showed greater AChE inhibition with an IC50 of 62.81 +- 0.01 mug/ml as compared to individual compounds, i.e., IC50 of curcumin at 134.5 +- 0.06 mug/ml and IC50 of piperine at 76.6 +- 0.08 mug/ml.	Curcumin	58-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	9-13
31507403-8	2019	In vitro AChE inhibition demonstrated that combination of curcumin and piperine showed greater AChE inhibition with an IC50 of 62.81 +- 0.01 mug/ml as compared to individual compounds, i.e., IC50 of curcumin at 134.5 +- 0.06 mug/ml and IC50 of piperine at 76.6 +- 0.08 mug/ml.	Curcumin	58-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-99
31511778-0	2019	Curcumin Inhibits Joint Contracture through PTEN Demethylation and Targeting PI3K/Akt/mTOR Pathway in Myofibroblasts from Human Joint Capsule.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	82-85
31894682-9	2019	Compared with the BDL group, the serum levels of ALT and AST in the curcumin treatment group were decreased significantly (P&lt;0.05), collagen deposition and inflammatory cell infiltration were improved, and HO-1 expression was increased (P&lt;0.05) after curcumin treatement.	Curcumin	68-76	heme oxygenase 1	Mus musculus	209-213
31894682-10	2019	In the curcumin treatment group, the protective effect of curcumin on liver injury could be reversed by HO-1 active inhibitor ZnPP.	Curcumin	7-15	heme oxygenase 1	Mus musculus	104-108
31894682-10	2019	In the curcumin treatment group, the protective effect of curcumin on liver injury could be reversed by HO-1 active inhibitor ZnPP.	Curcumin	58-66	heme oxygenase 1	Mus musculus	104-108
31894682-11	2019	CONCLUSION: Curcumin can improve liver inflammation and fibrosis caused by BDL, and this protective effect is related to the regulation of HO-1 activity by curcumin.	Curcumin	12-20	heme oxygenase 1	Mus musculus	139-143
31894682-11	2019	CONCLUSION: Curcumin can improve liver inflammation and fibrosis caused by BDL, and this protective effect is related to the regulation of HO-1 activity by curcumin.	Curcumin	156-164	heme oxygenase 1	Mus musculus	139-143
31530996-7	2019	Objective: To investigate whether curcumin can play a protective role against PM2.5-induced oxidative stress and inflammatory damage by inducing expression of the HO-1/CO/P38 MAPK pathway.	Curcumin	34-42	heme oxygenase 1	Mus musculus	163-170
31530996-16	2019	The results showed that the expression of the HO-1/CO/P38 MAPK protein in the lung tissue was significantly increased in the curcumin intervention group compared with the PM2.5 treatment group, and it was statistically significant (P &lt; 0.05).	Curcumin	125-133	heme oxygenase 1	Mus musculus	46-53
31530996-17	2019	Compared with the PM2.5 treatment group, the curcumin intervention group can reduce the amount of ALB, LDH, and ALP in BALF; reduce the levels of MDA, IL-1, and TNF-alpha in the lung tissue; and improve GSH-PX, T-AOC, and CAT levels, but there is no statistical difference (P &gt; 0.05).	Curcumin	45-53	tumor necrosis factor	Mus musculus	161-170
31530996-20	2019	The intervention of curcumin can further increase the expression of HO-1/CO/P38 MAPK.	Curcumin	20-28	heme oxygenase 1	Mus musculus	68-75
31432995-0	2019	Involvement of TLR4 in the protective effect of intra-articular administration of curcumin on rat experimental osteoarthritis.	Curcumin	82-90	toll-like receptor 4	Rattus norvegicus	15-19
31432995-7	2019	RESULTS: Intra-articular administration of curcumin significantly improved articular cartilage injury, suppressed synovial inflammation and down-regulated the overexpression of TLR4 and its downstream NF-kappaB caused by LPS-induced TLR4 activation in rat osteoarthritic knees.	Curcumin	43-51	toll-like receptor 4	Rattus norvegicus	177-181
31432995-7	2019	RESULTS: Intra-articular administration of curcumin significantly improved articular cartilage injury, suppressed synovial inflammation and down-regulated the overexpression of TLR4 and its downstream NF-kappaB caused by LPS-induced TLR4 activation in rat osteoarthritic knees.	Curcumin	43-51	toll-like receptor 4	Rattus norvegicus	233-237
31432995-8	2019	CONCLUSION: The data suggested that the inhibition of TLR4 signal might be an important mechanism underlying a protective effect of local curcumin administration on OA.	Curcumin	138-146	toll-like receptor 4	Rattus norvegicus	54-58
31511778-0	2019	Curcumin Inhibits Joint Contracture through PTEN Demethylation and Targeting PI3K/Akt/mTOR Pathway in Myofibroblasts from Human Joint Capsule.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	86-90
31496695-12	2019	CUR loaded ALN-HA-C18 micelles exhibited much higher cytotoxic activity against MG-63 cells compared to free CUR.	Curcumin	0-3	Bardet-Biedl syndrome 9	Homo sapiens	18-21
31399137-1	2019	OBJECTIVE: We recently reported that curcumin supplementation in a metabolically (i.e., Western diet [WD]) and chemically (i.e., CCl4) induced female rat model of non-alcoholic steatohepatitis (NASH) was associated with lower liver pathology scores and molecular markers of inflammation.	Curcumin	37-45	C-C motif chemokine ligand 4	Rattus norvegicus	129-133
30980365-7	2019	Curcumin can exert chemo-preventive effects by inhibition and reversal of the EMT process through both TGF-beta-dependent (e.g. in hepatoma and retinal pigment epithelial cancer) and -independent (e.g. in oral cancer, colorectal cancer, pancreatic cancer, hepatocellular carcinoma, breast cancer, melanoma, prostate cancer, bladder cancer, thyroid cancer and lung cancer) pathways.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	103-111
30993920-12	2019	HFD+curcumin+capsaicin caused decreased BAX, caspase-3, TOS, and ROS levels as compared to HFD, but increased TAS and Bcl-2.	Curcumin	4-12	BCL2, apoptosis regulator	Rattus norvegicus	118-123
30607623-0	2019	Therapeutic effects of curcumin on age-induced alterations in daily rhythms of clock genes and Sirt1 expression in the SCN of male Wistar rats.	Curcumin	23-31	sirtuin 1	Rattus norvegicus	95-100
30607623-7	2019	However, in old aged rats the phase and daily pulse of rPer1 were restored with curcumin treatment.	Curcumin	80-88	period circadian regulator 1	Rattus norvegicus	55-60
30607623-10	2019	In addition, strong interlocking interactions between rSirt1 and clock genes were observed in young age which were disrupted with aging and curcumin administration resulted in partial restoration.	Curcumin	140-148	sirtuin 1	Rattus norvegicus	54-60
31154107-9	2019	Depletion of p300 by siRNA or inhibition of p300 by curcumin attenuated Elovl3 trans-activation in prostate cancer cells.	Curcumin	52-60	ELOVL fatty acid elongase 3	Homo sapiens	72-78
30771095-2	2019	However, it is challenging to study curcumin as it exhibits poor aqueous solubility and low permeability and it is a substrate for P-glycoprotein (P-gp).	Curcumin	36-44	ATP binding cassette subfamily B member 1	Homo sapiens	131-145
31079683-7	2019	They also increased the anti-inflammatory effect of curcumin in TNF-alpha-induced inflammation experiments.	Curcumin	52-60	tumor necrosis factor	Homo sapiens	64-73
30771095-2	2019	However, it is challenging to study curcumin as it exhibits poor aqueous solubility and low permeability and it is a substrate for P-glycoprotein (P-gp).	Curcumin	36-44	ATP binding cassette subfamily B member 1	Homo sapiens	147-151
31270880-8	2019	The curcumin compounds modulated pro-MMP-2 levels and increased TIMP-1 production.	Curcumin	4-12	TIMP metallopeptidase inhibitor 1	Homo sapiens	64-70
31270880-11	2019	In conclusion, synthetic curcumins influenced the balance between pro-MMP-2 and TIMP-1 in human periodontal stem cells in vitro, and this could open perspectives for their application as adjuvants in periodontal therapy.	Curcumin	25-34	TIMP metallopeptidase inhibitor 1	Homo sapiens	80-86
31316605-6	2019	Curcumin significantly downregulated VEGF concentration, suppressed vascular lumen formation and inhibited invasion cell numbers in a dose-dependent manner.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	37-41
31034781-10	2019	Mechanistic in vitro studies showed that curcumin reduced Mb-mediated inflammation and oxidative stress by inhibiting the TLR4/NF-kappaB axis and activating the cytoprotective enzyme heme oxygenase 1.	Curcumin	41-49	toll-like receptor 4	Mus musculus	122-126
31034781-10	2019	Mechanistic in vitro studies showed that curcumin reduced Mb-mediated inflammation and oxidative stress by inhibiting the TLR4/NF-kappaB axis and activating the cytoprotective enzyme heme oxygenase 1.	Curcumin	41-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	127-136
31034781-10	2019	Mechanistic in vitro studies showed that curcumin reduced Mb-mediated inflammation and oxidative stress by inhibiting the TLR4/NF-kappaB axis and activating the cytoprotective enzyme heme oxygenase 1.	Curcumin	41-49	heme oxygenase 1	Mus musculus	183-199
31316605-8	2019	HIF-1alpha protein expression levels in the nucleus of the curcumin-treated groups were significantly suppressed in a dose-dependent manner compared with the platelet group.	Curcumin	59-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
31316605-9	2019	In conclusion, curcumin suppressed INMEC invasion and angiogenesis induced by activated platelets via inhibiting the activation of the PI3K/AKT/mTOR pathway.	Curcumin	15-23	AKT serine/threonine kinase 1	Homo sapiens	140-143
31316605-9	2019	In conclusion, curcumin suppressed INMEC invasion and angiogenesis induced by activated platelets via inhibiting the activation of the PI3K/AKT/mTOR pathway.	Curcumin	15-23	mechanistic target of rapamycin kinase	Homo sapiens	144-148
30470954-0	2019	Intranasal curcumin protects against LPS-induced airway remodeling by modulating toll-like receptor-4 (TLR-4) and matrixmetalloproteinase-9 (MMP-9) expression via affecting MAP kinases in mouse model.	Curcumin	11-19	toll-like receptor 4	Mus musculus	81-101
30470954-0	2019	Intranasal curcumin protects against LPS-induced airway remodeling by modulating toll-like receptor-4 (TLR-4) and matrixmetalloproteinase-9 (MMP-9) expression via affecting MAP kinases in mouse model.	Curcumin	11-19	toll-like receptor 4	Mus musculus	103-108
30623450-9	2019	Curcumin can also upregulate the expression and activity of p53 that inhibits tumor cell proliferation and increases apoptosis.	Curcumin	0-8	tumor protein p53	Homo sapiens	60-63
31018701-0	2019	Curcumin induces p53-independent inactivation of Nrf2 during oxidative stress-induced apoptosis.	Curcumin	0-8	tumor protein p53	Homo sapiens	17-20
31018701-0	2019	Curcumin induces p53-independent inactivation of Nrf2 during oxidative stress-induced apoptosis.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
31018701-6	2019	Interestingly, at early times of exposure to a proapoptotic dose of curcumin (15 muM), we observed nuclear accumulation of Nrf2 and the expression of Nrf2 target genes, whereas at late exposure times we found a reduction of total and nuclear protein levels of Nrf2 as well as downregulation of Nrf2 target genes in the absence of p53 activation.	Curcumin	68-76	latexin	Homo sapiens	81-84
31018701-6	2019	Interestingly, at early times of exposure to a proapoptotic dose of curcumin (15 muM), we observed nuclear accumulation of Nrf2 and the expression of Nrf2 target genes, whereas at late exposure times we found a reduction of total and nuclear protein levels of Nrf2 as well as downregulation of Nrf2 target genes in the absence of p53 activation.	Curcumin	68-76	NFE2 like bZIP transcription factor 2	Homo sapiens	123-127
31018701-6	2019	Interestingly, at early times of exposure to a proapoptotic dose of curcumin (15 muM), we observed nuclear accumulation of Nrf2 and the expression of Nrf2 target genes, whereas at late exposure times we found a reduction of total and nuclear protein levels of Nrf2 as well as downregulation of Nrf2 target genes in the absence of p53 activation.	Curcumin	68-76	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
31018701-6	2019	Interestingly, at early times of exposure to a proapoptotic dose of curcumin (15 muM), we observed nuclear accumulation of Nrf2 and the expression of Nrf2 target genes, whereas at late exposure times we found a reduction of total and nuclear protein levels of Nrf2 as well as downregulation of Nrf2 target genes in the absence of p53 activation.	Curcumin	68-76	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
31018701-6	2019	Interestingly, at early times of exposure to a proapoptotic dose of curcumin (15 muM), we observed nuclear accumulation of Nrf2 and the expression of Nrf2 target genes, whereas at late exposure times we found a reduction of total and nuclear protein levels of Nrf2 as well as downregulation of Nrf2 target genes in the absence of p53 activation.	Curcumin	68-76	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
31018701-6	2019	Interestingly, at early times of exposure to a proapoptotic dose of curcumin (15 muM), we observed nuclear accumulation of Nrf2 and the expression of Nrf2 target genes, whereas at late exposure times we found a reduction of total and nuclear protein levels of Nrf2 as well as downregulation of Nrf2 target genes in the absence of p53 activation.	Curcumin	68-76	tumor protein p53	Homo sapiens	330-333
31028577-0	2019	Curcumin Modulates Paraquat-Induced Epithelial to Mesenchymal Transition by Regulating Transforming Growth Factor-beta (TGF-beta) in A549 Cells.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	87-118
31028577-5	2019	Western blot and immunocytochemistry studies revealed that pretreatment of A549 cells with curcumin for 3 h before PQ exposure has maintained E-cadherin expression and inhibited PQ induced alpha-smooth-muscle actin (alpha-SMA) expression.	Curcumin	91-99	cadherin 1	Homo sapiens	142-152
31028577-5	2019	Western blot and immunocytochemistry studies revealed that pretreatment of A549 cells with curcumin for 3 h before PQ exposure has maintained E-cadherin expression and inhibited PQ induced alpha-smooth-muscle actin (alpha-SMA) expression.	Curcumin	91-99	actin alpha 1, skeletal muscle	Homo sapiens	216-225
30900133-5	2019	To address this issue, tetrahydrocurcumin (THC), a colorless derivative of curcumin, was subjected to in silico screening (molecular docking and dynamics simulation studies) using homology model of gp120-CD4 binding.	Curcumin	33-41	CD4 molecule	Homo sapiens	204-207
31173176-0	2019	Curcumin-loaded PEG-PDLLA nanoparticles for attenuating palmitate-induced oxidative stress and cardiomyocyte apoptosis through AMPK pathway.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	127-131
30770549-0	2019	Curcumin prevents high glucose damage in retinal pigment epithelial cells through ERK1/2-mediated activation of the Nrf2/HO-1 pathway.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	82-88
30770549-0	2019	Curcumin prevents high glucose damage in retinal pigment epithelial cells through ERK1/2-mediated activation of the Nrf2/HO-1 pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	116-120
30770549-5	2019	Further, curcumin was able to induce HO-1 expression via Nrf2 activation and counteracts the damage elicited by HG.	Curcumin	9-17	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
30770549-6	2019	The present study demonstrated that curcumin provides protection against HG-induced damage in RPE cells through the activation of Nrf2/HO-1 signaling that involves the ERK pathway, suggesting that curcumin may have therapeutic value in the treatment of diabetic retinopathy.	Curcumin	36-44	NFE2 like bZIP transcription factor 2	Homo sapiens	130-134
30770549-6	2019	The present study demonstrated that curcumin provides protection against HG-induced damage in RPE cells through the activation of Nrf2/HO-1 signaling that involves the ERK pathway, suggesting that curcumin may have therapeutic value in the treatment of diabetic retinopathy.	Curcumin	36-44	mitogen-activated protein kinase 1	Homo sapiens	168-171
30770549-6	2019	The present study demonstrated that curcumin provides protection against HG-induced damage in RPE cells through the activation of Nrf2/HO-1 signaling that involves the ERK pathway, suggesting that curcumin may have therapeutic value in the treatment of diabetic retinopathy.	Curcumin	197-205	NFE2 like bZIP transcription factor 2	Homo sapiens	130-134
30770549-6	2019	The present study demonstrated that curcumin provides protection against HG-induced damage in RPE cells through the activation of Nrf2/HO-1 signaling that involves the ERK pathway, suggesting that curcumin may have therapeutic value in the treatment of diabetic retinopathy.	Curcumin	197-205	mitogen-activated protein kinase 1	Homo sapiens	168-171
30623450-10	2019	Furthermore, curcumin has a potent inhibitory effect on the activity of NF-kappaB and COX-2, which are involved in the overexpression of antiapoptosis genes such as Bcl-2.	Curcumin	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
30623450-10	2019	Furthermore, curcumin has a potent inhibitory effect on the activity of NF-kappaB and COX-2, which are involved in the overexpression of antiapoptosis genes such as Bcl-2.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	165-170
31029341-0	2019	Folate-PEG/Hyd-curcumin/C18-g-PSI micelles for site specific delivery of curcumin to colon cancer cells via Wnt/beta-catenin signaling pathway.	Curcumin	73-81	Bardet-Biedl syndrome 9	Homo sapiens	24-27
31466778-10	2019	Furthermore, PCNA, TLR4 and its downstream gene expression as well as protein expression (TLR4, NF-kappaB and PCNA) were significantly down regulated in heat stress curcumin supplemented group as compared to HC and NC group.	Curcumin	165-173	proliferating cell nuclear antigen	Gallus gallus	110-114
31466778-10	2019	Furthermore, PCNA, TLR4 and its downstream gene expression as well as protein expression (TLR4, NF-kappaB and PCNA) were significantly down regulated in heat stress curcumin supplemented group as compared to HC and NC group.	Curcumin	165-173	proliferating cell nuclear antigen	Gallus gallus	13-17
30604346-4	2019	Then, biofilms were treated with associations of 600 mumol L-1 curcumin combined or not with 1% EDTA and 37.5 or 75 J cm-2 LED (455 nm).	Curcumin	63-71	immunoglobulin kappa variable 1-16	Homo sapiens	59-62
31206225-7	2019	RESULTS: Curcumin supplementation had a significant effect on IL-6 levels and oxidative stress markers including TAC and MDA in crude model.	Curcumin	9-17	interleukin 6	Homo sapiens	62-66
31029908-9	2019	Meanwhile, curcumin alleviated the oxidative stress response via reducing MDA content and increasing SOD, CAT, GPx, GR and GSH levels in this animal model.	Curcumin	11-19	catalase	Mus musculus	106-109
31029908-9	2019	Meanwhile, curcumin alleviated the oxidative stress response via reducing MDA content and increasing SOD, CAT, GPx, GR and GSH levels in this animal model.	Curcumin	11-19	nuclear receptor subfamily 3, group C, member 1	Mus musculus	116-118
31029908-11	2019	Curcumin also attenuated the high expression of IL-6, MCP-1, OPN, CD44, alpha-SMA, Collagen I and collagen fibril deposition, which were elevated by hyperoxaluria.	Curcumin	0-8	interleukin 6	Mus musculus	48-52
31029908-11	2019	Curcumin also attenuated the high expression of IL-6, MCP-1, OPN, CD44, alpha-SMA, Collagen I and collagen fibril deposition, which were elevated by hyperoxaluria.	Curcumin	0-8	mast cell protease 1	Mus musculus	54-59
31029908-11	2019	Curcumin also attenuated the high expression of IL-6, MCP-1, OPN, CD44, alpha-SMA, Collagen I and collagen fibril deposition, which were elevated by hyperoxaluria.	Curcumin	0-8	actin alpha 2, smooth muscle, aorta	Mus musculus	72-81
31029908-12	2019	Furthermore, the results revealed that both the total expression and nuclear accumulation of Nrf2, as well as its main downstream products such as HO-1, NQO1 and UGT, were decreased in the kidneys of mice in the crystal group, while treatment with curcumin could rescue this deterioration.	Curcumin	248-256	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
31029908-12	2019	Furthermore, the results revealed that both the total expression and nuclear accumulation of Nrf2, as well as its main downstream products such as HO-1, NQO1 and UGT, were decreased in the kidneys of mice in the crystal group, while treatment with curcumin could rescue this deterioration.	Curcumin	248-256	heme oxygenase 1	Mus musculus	147-151
31029908-12	2019	Furthermore, the results revealed that both the total expression and nuclear accumulation of Nrf2, as well as its main downstream products such as HO-1, NQO1 and UGT, were decreased in the kidneys of mice in the crystal group, while treatment with curcumin could rescue this deterioration.	Curcumin	248-256	solute carrier family 35 (UDP-galactose transporter), member A2	Mus musculus	162-165
31206225-8	2019	After controlling the effects of confounders, curcumin supplementation had a substantial effect on inflammation (hs-CRP and IL-6) and oxidative stress (TAC) marker of adolescents.	Curcumin	46-54	interleukin 6	Homo sapiens	124-128
31331376-6	2019	Curcumin act as PPARgamma agonists.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	16-25
31372175-0	2019	Dietary curcumin enhances insulin clearance in diet-induced obese mice via regulation of hepatic PI3K-AKT axis and IDE, and preservation of islet integrity.	Curcumin	8-16	thymoma viral proto-oncogene 1	Mus musculus	102-105
31372175-0	2019	Dietary curcumin enhances insulin clearance in diet-induced obese mice via regulation of hepatic PI3K-AKT axis and IDE, and preservation of islet integrity.	Curcumin	8-16	insulin degrading enzyme	Mus musculus	115-118
31332165-10	2019	In addition, MHY1485, an activator of mTOR, reduced Hcy-induced increase in LC3 and Beclin 1 protein levels, meanwhile ERK and PI3K activators (TPA, curcumin for ERK and IGF-1 for PI3K, respectively) enhanced Hcy-triggered mTOR inhibition in OGD/R NSCs.	Curcumin	149-157	mechanistic target of rapamycin kinase	Homo sapiens	38-42
31332165-10	2019	In addition, MHY1485, an activator of mTOR, reduced Hcy-induced increase in LC3 and Beclin 1 protein levels, meanwhile ERK and PI3K activators (TPA, curcumin for ERK and IGF-1 for PI3K, respectively) enhanced Hcy-triggered mTOR inhibition in OGD/R NSCs.	Curcumin	149-157	mitogen-activated protein kinase 1	Homo sapiens	162-165
31331376-10	2019	By stimulating PPARgamma expression, curcumin can control circadian clocks through the regulation of many key circadian genes.	Curcumin	37-45	peroxisome proliferator activated receptor gamma	Homo sapiens	15-24
31331376-11	2019	The administration of curcumin in cancer treatment would thus appear to be an interesting therapeutic strategy, which acts through their role in regulating WNT/beta-catenin pathway and PPARgamma activity levels.	Curcumin	22-30	peroxisome proliferator activated receptor gamma	Homo sapiens	185-194
31316146-8	2019	Moreover, phytosomal curcumin exerted considerably stronger effects on activation of anti-inflammatory PPARgamma as well as inhibition of pro-inflammatory NF-kappaB than unformulated curcumin.	Curcumin	21-29	peroxisome proliferator activated receptor gamma	Homo sapiens	103-112
31325292-11	2019	RESULTS OMT and Curcumin (an Nrf2 agonist) attenuated aldosterone (ALD)-induced proliferation and migration in CFBs, as well as the fibrosis-associated protein expression levels.	Curcumin	16-24	NFE2 like bZIP transcription factor 2	Rattus norvegicus	29-33
31319868-4	2019	We have previously shown that curcumin and some of its analogues harboring an alpha,beta-unsaturated 1,3-diketone moiety, able to coordinate the magnesium ion, can interfere with LPS-mediated TLR4-myeloid differentiation protein-2 (MD-2) signaling.	Curcumin	30-38	toll-like receptor 4	Mus musculus	192-196
31317354-3	2019	Curcumin is one such natural product which provides numerous beneficial effects including antioxidant, anti-inflammatory, and anti-VEGF activities and has the potential for the treatment of both types of AMD.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	131-135
31428357-0	2019	Curcumin encapsulation and protection based on lysozyme nanoparticles.	Curcumin	0-8	lysozyme	Homo sapiens	47-55
31428357-3	2019	In this paper, lysozyme nanoparticles were fabricated through solvent evaporation, and then, the solubilization and protection capability of curcumin were investigated.	Curcumin	141-149	lysozyme	Homo sapiens	15-23
31428357-8	2019	After encapsulation by lysozyme nanoparticles, the retentive curcumin can reach up to 67.9% and 30.25% at 25 C and 50 C, respectively, significantly higher than that of free curcumin.	Curcumin	61-69	lysozyme	Homo sapiens	23-31
31428357-8	2019	After encapsulation by lysozyme nanoparticles, the retentive curcumin can reach up to 67.9% and 30.25% at 25 C and 50 C, respectively, significantly higher than that of free curcumin.	Curcumin	174-182	lysozyme	Homo sapiens	23-31
31428357-9	2019	Meanwhile, experiments on DPPH free radicals indicated the curcumin loaded by lysozyme nanoparticle possessed higher free radical scavenging activity than that of free curcumin with same treatments.	Curcumin	59-67	lysozyme	Homo sapiens	78-86
31428357-9	2019	Meanwhile, experiments on DPPH free radicals indicated the curcumin loaded by lysozyme nanoparticle possessed higher free radical scavenging activity than that of free curcumin with same treatments.	Curcumin	168-176	lysozyme	Homo sapiens	78-86
31316146-9	2019	Furthermore, phytosomal curcumin showed a comparable effect on suppression of oncogenic mTOR activation to unformulated curcumin.	Curcumin	24-32	mechanistic target of rapamycin kinase	Homo sapiens	88-92
30827608-2	2019	In this study, the interactions of beta-casein with curcumin and vitamin D3 under the same physico-chemical conditions were investigated.	Curcumin	52-60	casein beta	Bos taurus	35-46
31360301-0	2019	A novel curcumin analog inhibits canonical and non-canonical functions of telomerase through STAT3 and NF-kappaB inactivation in colorectal cancer cells.	Curcumin	8-16	signal transducer and activator of transcription 3	Homo sapiens	93-98
31360301-0	2019	A novel curcumin analog inhibits canonical and non-canonical functions of telomerase through STAT3 and NF-kappaB inactivation in colorectal cancer cells.	Curcumin	8-16	nuclear factor kappa B subunit 1	Homo sapiens	103-112
30827608-4	2019	The KD value for curcumin-beta-casein interaction has been successfully evaluated (4.1 +- 0.7 x 10-4 M) using SPR by fitting data to a 1:1 Langmuir interaction model.	Curcumin	17-25	casein beta	Bos taurus	26-37
30827608-6	2019	Moreover, the fluorescence quenching data show that curcumin has higher affinity to beta-casein (KA = 23.5 +- 1.9 x 104 M-1) than vitamin D3 (KA = 5.8 +- 1.1 x 104 M-1).	Curcumin	52-60	casein beta	Bos taurus	84-95
31417656-0	2019	Effects of Notch Signaling Pathway in Cervical Cancer by Curcumin Mediated Photodynamic Therapy and Its Possible Mechanisms in Vitro and in Vivo.	Curcumin	57-65	notch receptor 1	Homo sapiens	11-16
31295875-9	2019	The data indicate that curcumin modulates autophagy by classic signaling pathways (suppression of protein kinase B (Akt)/mammalian target of rapamycin (mTOR) and/or by stimulation of adenosine monophosphate-activated protein kinase (AMPK) and extracellular signal-dependent kinase (ERK) pathways).	Curcumin	23-31	AKT serine/threonine kinase 1	Homo sapiens	116-119
31295875-9	2019	The data indicate that curcumin modulates autophagy by classic signaling pathways (suppression of protein kinase B (Akt)/mammalian target of rapamycin (mTOR) and/or by stimulation of adenosine monophosphate-activated protein kinase (AMPK) and extracellular signal-dependent kinase (ERK) pathways).	Curcumin	23-31	mechanistic target of rapamycin kinase	Homo sapiens	121-150
31295875-9	2019	The data indicate that curcumin modulates autophagy by classic signaling pathways (suppression of protein kinase B (Akt)/mammalian target of rapamycin (mTOR) and/or by stimulation of adenosine monophosphate-activated protein kinase (AMPK) and extracellular signal-dependent kinase (ERK) pathways).	Curcumin	23-31	mechanistic target of rapamycin kinase	Homo sapiens	152-156
31295875-9	2019	The data indicate that curcumin modulates autophagy by classic signaling pathways (suppression of protein kinase B (Akt)/mammalian target of rapamycin (mTOR) and/or by stimulation of adenosine monophosphate-activated protein kinase (AMPK) and extracellular signal-dependent kinase (ERK) pathways).	Curcumin	23-31	mitogen-activated protein kinase 1	Homo sapiens	243-280
31417656-4	2019	Therefore, in this study, we explored the effects of Notch signaling pathway in cervical cancer by curcumin mediated PDT with/without Notch receptor blocker (DAPT), and hope to elucidate its mechanism.	Curcumin	99-107	notch receptor 1	Homo sapiens	53-58
31295875-9	2019	The data indicate that curcumin modulates autophagy by classic signaling pathways (suppression of protein kinase B (Akt)/mammalian target of rapamycin (mTOR) and/or by stimulation of adenosine monophosphate-activated protein kinase (AMPK) and extracellular signal-dependent kinase (ERK) pathways).	Curcumin	23-31	mitogen-activated protein kinase 1	Homo sapiens	282-285
31417656-11	2019	Notch signaling pathway could be one of the targets of curcumin-PDT photodynamic therapy.	Curcumin	55-63	notch receptor 1	Homo sapiens	0-5
30585634-6	2019	Nano micelles curcumin suppressed cell growth in U-373 cells via modulation of Wnt and NF-kappaB pathways.	Curcumin	14-22	nuclear factor kappa B subunit 1	Homo sapiens	87-96
30993734-2	2019	The aim of this study is to inhibit amyloidogenesis by using preparatory polymeric nanomicelles as therapeutic agents and also as nanocarriers for curcumin to target Abeta fibrils through the glycation method of bovine serum albumin (BSA) in the presence of phosphate-buffered saline.	Curcumin	147-155	amyloid beta precursor protein	Homo sapiens	166-171
30993734-2	2019	The aim of this study is to inhibit amyloidogenesis by using preparatory polymeric nanomicelles as therapeutic agents and also as nanocarriers for curcumin to target Abeta fibrils through the glycation method of bovine serum albumin (BSA) in the presence of phosphate-buffered saline.	Curcumin	147-155	albumin	Homo sapiens	219-232
30915623-0	2019	Curcumin Can Improve Spinal Cord Injury by Inhibiting TGF-beta-SOX9 Signaling Pathway.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	54-62
30915623-6	2019	Curcumin can play an important role in SCI recovery by inhibiting the expression of NF-kappaB and TGF-beta-SOX9.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	98-106
31745043-1	2019	Purpose: The purpose of this study was to assess the efficacy of mouthwash containing essential oils and curcumin (MEC) as an adjunct to nonsurgical periodontal therapy on the disease activity of rheumatoid arthritis (RA) among RA patients with chronic periodontitis (CP).	Curcumin	105-113	C-C motif chemokine ligand 28	Homo sapiens	115-118
30951849-10	2019	We conclude that curcumin is an immunomodulatory treatment capable of emulating anti-Abeta vaccine in stimulating phagocytic clearance of amyloid by reducing CD33 and increasing TREM2 and TyroBP, while restoring neuroinflammatory networks implicated in neurodegenerative diseases.	Curcumin	17-25	CD33 molecule	Homo sapiens	158-162
30951849-10	2019	We conclude that curcumin is an immunomodulatory treatment capable of emulating anti-Abeta vaccine in stimulating phagocytic clearance of amyloid by reducing CD33 and increasing TREM2 and TyroBP, while restoring neuroinflammatory networks implicated in neurodegenerative diseases.	Curcumin	17-25	triggering receptor expressed on myeloid cells 2	Homo sapiens	178-183
31602860-7	2019	Moreover,curcumin could inhibit the migration and invasion of MKN45 cells,downregulate the expression of N-cadherin,snail1,Wnt3 a,p-beta-catenin,p-LRP6 and Bcl-2,and upregulate the expression of E-cadherin and Bax,it could increase the activity of caspase-3,caspase-8,caspase-9 and induce apoptosis as well.	Curcumin	9-17	snail family transcriptional repressor 1	Homo sapiens	116-122
31602860-7	2019	Moreover,curcumin could inhibit the migration and invasion of MKN45 cells,downregulate the expression of N-cadherin,snail1,Wnt3 a,p-beta-catenin,p-LRP6 and Bcl-2,and upregulate the expression of E-cadherin and Bax,it could increase the activity of caspase-3,caspase-8,caspase-9 and induce apoptosis as well.	Curcumin	9-17	BCL2 apoptosis regulator	Homo sapiens	156-161
31602860-7	2019	Moreover,curcumin could inhibit the migration and invasion of MKN45 cells,downregulate the expression of N-cadherin,snail1,Wnt3 a,p-beta-catenin,p-LRP6 and Bcl-2,and upregulate the expression of E-cadherin and Bax,it could increase the activity of caspase-3,caspase-8,caspase-9 and induce apoptosis as well.	Curcumin	9-17	cadherin 1	Homo sapiens	195-205
31602860-7	2019	Moreover,curcumin could inhibit the migration and invasion of MKN45 cells,downregulate the expression of N-cadherin,snail1,Wnt3 a,p-beta-catenin,p-LRP6 and Bcl-2,and upregulate the expression of E-cadherin and Bax,it could increase the activity of caspase-3,caspase-8,caspase-9 and induce apoptosis as well.	Curcumin	9-17	BCL2 associated X, apoptosis regulator	Homo sapiens	210-213
31602860-7	2019	Moreover,curcumin could inhibit the migration and invasion of MKN45 cells,downregulate the expression of N-cadherin,snail1,Wnt3 a,p-beta-catenin,p-LRP6 and Bcl-2,and upregulate the expression of E-cadherin and Bax,it could increase the activity of caspase-3,caspase-8,caspase-9 and induce apoptosis as well.	Curcumin	9-17	caspase 3	Homo sapiens	248-257
31252572-0	2019	Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells.	Curcumin	0-8	cytokine inducible SH2-containing protein	Mus musculus	59-63
31252572-5	2019	The present experiments show that the administration of curcumin is able to increase the production of the anti-inflammatory cytokines, IL-4 and IL-10, in murine BV-2 microglial cells treated with lipopolysaccharide (LPS).	Curcumin	56-64	interleukin 10	Mus musculus	145-150
31234318-5	2019	Curcumin-suppressed NF-kappaB was identified through inhibition of PLCG1, PIK3R1, and MALT1 in the CD4-T-cell-receptor-signaling NF-kappaB cascade pathway.	Curcumin	0-8	phospholipase C gamma 1	Homo sapiens	67-72
31172987-6	2019	WZ35, a novel curcumin derivative, exhibits potential anti-tumor activity in gastric cancer cells by regulating ROS dependent JNK activation and ER stress.	Curcumin	14-22	mitogen-activated protein kinase 8	Homo sapiens	126-129
31276550-1	2019	Despite its poor bioavailability, curcumin is a promising natural polyphenol targeting NF-kappabeta.	Curcumin	34-42	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-99
31005039-10	2019	In vitro curcumin inhibited the degradation of IkappaBalpha and reduced the production of COX-2 in LPS-induced inflammatory RAW264.7 cells.	Curcumin	9-17	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	47-59
30421467-17	2019	CXCL1 and TNF-alpha both represent potential biomarkers for the future study of curcumin chemoprevention.	Curcumin	80-88	tumor necrosis factor	Homo sapiens	10-19
30951849-9	2019	Like curcumin, anti-Abeta antibody (also reported to engage the Syk pathway, increase CD68, and decrease amyloid burden in human and mouse brain) increased TREM2 in APPsw mice and decreased amyloid in human AD sections ex vivo.	Curcumin	5-13	amyloid beta precursor protein	Homo sapiens	20-25
30951849-10	2019	We conclude that curcumin is an immunomodulatory treatment capable of emulating anti-Abeta vaccine in stimulating phagocytic clearance of amyloid by reducing CD33 and increasing TREM2 and TyroBP, while restoring neuroinflammatory networks implicated in neurodegenerative diseases.	Curcumin	17-25	amyloid beta precursor protein	Homo sapiens	85-90
31289524-10	2019	Furthermore, the radiosensitization effects of curcumin and cisplatin on NSCLC A549 cells, which include inhibition of proliferation, migration and invasion, may be associated with the inhibition of the EGFR-associated signaling pathway.	Curcumin	47-55	epidermal growth factor receptor	Homo sapiens	203-207
31680089-5	2019	Effect of curcumin on oxidative stress following UCMS was determined by measuring peroxidation of lipid (LPO) and antioxidant enzyme activities.	Curcumin	10-18	lactoperoxidase	Homo sapiens	105-108
31078267-0	2019	Curcumin upregulates the Nrf2 system by repressing inflammatory signaling-mediated Keap1 expression in insulin-resistant conditions.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	25-29
31078267-0	2019	Curcumin upregulates the Nrf2 system by repressing inflammatory signaling-mediated Keap1 expression in insulin-resistant conditions.	Curcumin	0-8	kelch like ECH associated protein 1	Homo sapiens	83-88
31078267-0	2019	Curcumin upregulates the Nrf2 system by repressing inflammatory signaling-mediated Keap1 expression in insulin-resistant conditions.	Curcumin	0-8	insulin	Homo sapiens	103-110
31078267-2	2019	Curcumin (Cur) not only has an anti-inflammatory effect but also has an antioxidative stress effect via the activation of NF-E2-related factor 2 (Nrf2).	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	122-144
31078267-2	2019	Curcumin (Cur) not only has an anti-inflammatory effect but also has an antioxidative stress effect via the activation of NF-E2-related factor 2 (Nrf2).	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	146-150
31078267-2	2019	Curcumin (Cur) not only has an anti-inflammatory effect but also has an antioxidative stress effect via the activation of NF-E2-related factor 2 (Nrf2).	Curcumin	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	122-144
31078267-2	2019	Curcumin (Cur) not only has an anti-inflammatory effect but also has an antioxidative stress effect via the activation of NF-E2-related factor 2 (Nrf2).	Curcumin	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	146-150
31252572-6	2019	Consistent with these data, curcumin stimulation upregulates the expression of Suppressors of cytokine signaling (SOCS)-1, whereas phosphorylation of the JAK2 and STAT3 was reduced.	Curcumin	28-36	signal transducer and activator of transcription 3	Mus musculus	163-168
31252572-7	2019	Taken together, these results provide evidence that curcumin is able to regulate neuroinflammatory reactions by eliciting anti-inflammatory responses in microglia through JAK/STAT/SOCS signaling pathway modulation.	Curcumin	52-60	cytokine inducible SH2-containing protein	Mus musculus	180-184
31234318-5	2019	Curcumin-suppressed NF-kappaB was identified through inhibition of PLCG1, PIK3R1, and MALT1 in the CD4-T-cell-receptor-signaling NF-kappaB cascade pathway.	Curcumin	0-8	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	74-80
31169275-8	2019	Our data pointed out, for the first time, that several genes involved in the modulation of apoptosis, including PMAIP1, BID, ZMAT3, CASP3, CASP7, and FAS, represent new targets of both singular and combinatorial treatments with resveratrol and curcumin, and also the combinatorial approach of curcumin and resveratrol exhibits a more powerful gene regulating effect compared to single treatment.	Curcumin	244-252	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	112-118
31169275-8	2019	Our data pointed out, for the first time, that several genes involved in the modulation of apoptosis, including PMAIP1, BID, ZMAT3, CASP3, CASP7, and FAS, represent new targets of both singular and combinatorial treatments with resveratrol and curcumin, and also the combinatorial approach of curcumin and resveratrol exhibits a more powerful gene regulating effect compared to single treatment.	Curcumin	244-252	BH3 interacting domain death agonist	Homo sapiens	120-123
31169275-8	2019	Our data pointed out, for the first time, that several genes involved in the modulation of apoptosis, including PMAIP1, BID, ZMAT3, CASP3, CASP7, and FAS, represent new targets of both singular and combinatorial treatments with resveratrol and curcumin, and also the combinatorial approach of curcumin and resveratrol exhibits a more powerful gene regulating effect compared to single treatment.	Curcumin	244-252	caspase 3	Homo sapiens	132-137
31169275-8	2019	Our data pointed out, for the first time, that several genes involved in the modulation of apoptosis, including PMAIP1, BID, ZMAT3, CASP3, CASP7, and FAS, represent new targets of both singular and combinatorial treatments with resveratrol and curcumin, and also the combinatorial approach of curcumin and resveratrol exhibits a more powerful gene regulating effect compared to single treatment.	Curcumin	293-301	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	112-118
31169275-8	2019	Our data pointed out, for the first time, that several genes involved in the modulation of apoptosis, including PMAIP1, BID, ZMAT3, CASP3, CASP7, and FAS, represent new targets of both singular and combinatorial treatments with resveratrol and curcumin, and also the combinatorial approach of curcumin and resveratrol exhibits a more powerful gene regulating effect compared to single treatment.	Curcumin	293-301	BH3 interacting domain death agonist	Homo sapiens	120-123
31169275-8	2019	Our data pointed out, for the first time, that several genes involved in the modulation of apoptosis, including PMAIP1, BID, ZMAT3, CASP3, CASP7, and FAS, represent new targets of both singular and combinatorial treatments with resveratrol and curcumin, and also the combinatorial approach of curcumin and resveratrol exhibits a more powerful gene regulating effect compared to single treatment.	Curcumin	293-301	caspase 3	Homo sapiens	132-137
30585634-8	2019	In the core signaling pathways of GBM, nano micelles curcumin either significantly influences the NF-kappaB pathway by decreasing p-65 expression or significantly inhibits the Wnt/beta-catenin pathway by declining cyclin D1 expression.	Curcumin	53-61	nuclear factor kappa B subunit 1	Homo sapiens	98-107
30585634-9	2019	In conclusion, we have shown that nano micelles curcumin effectively prevent proliferation, and invasion of GBM cells through perturbation of Wnt/beta-catenin and NF-kappaB pathways, suggesting further investigations on the therapeutic application of this novel anticancer drug in in vivo models.	Curcumin	48-56	nuclear factor kappa B subunit 1	Homo sapiens	163-172
31199764-9	2019	Oral administration of curcumin (20 mg/kg body weight/day) in arsenic-treated rats significantly reinstated these alterations of the antioxidant system followed by an improvement of ovarian steroidogenesis and the circulating level of B12 and folate along with the downregulation of serum homocysteine, metallothionein-1, and cytokines.	Curcumin	23-31	metallothionein 1	Rattus norvegicus	303-320
31275848-0	2019	Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	67-70
31275848-7	2019	Curcumin induces apoptosis in B-Pre-ALL cell lines via activation of caspase-8 and truncation of BID.	Curcumin	0-8	BH3 interacting domain death agonist	Homo sapiens	97-100
31275848-8	2019	Curcumin treatment increased the ratio of Bax/Bcl-2 and resulted in a leaky mitochondrial membrane that led to the discharge of cytochrome c from the mitochondria to the cytoplasm, the activation of caspase 3 and the cleavage of PARP.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	42-45
31275848-8	2019	Curcumin treatment increased the ratio of Bax/Bcl-2 and resulted in a leaky mitochondrial membrane that led to the discharge of cytochrome c from the mitochondria to the cytoplasm, the activation of caspase 3 and the cleavage of PARP.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	46-51
31275848-8	2019	Curcumin treatment increased the ratio of Bax/Bcl-2 and resulted in a leaky mitochondrial membrane that led to the discharge of cytochrome c from the mitochondria to the cytoplasm, the activation of caspase 3 and the cleavage of PARP.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	128-140
31275848-8	2019	Curcumin treatment increased the ratio of Bax/Bcl-2 and resulted in a leaky mitochondrial membrane that led to the discharge of cytochrome c from the mitochondria to the cytoplasm, the activation of caspase 3 and the cleavage of PARP.	Curcumin	0-8	caspase 3	Homo sapiens	199-208
31275848-9	2019	Curcumin treatment of B-Pre-ALL cell lines induced a dephosphorylation of the constitutive phosphorylated AKT/PKB and a down-regulation of the expression of cIAP1, and XIAP.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	106-109
31275848-9	2019	Curcumin treatment of B-Pre-ALL cell lines induced a dephosphorylation of the constitutive phosphorylated AKT/PKB and a down-regulation of the expression of cIAP1, and XIAP.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	110-113
31275848-12	2019	Altogether, these results suggest an important therapeutic role of curcumin, acting as a growth suppressor of B-Pre-ALL by apoptosis via inactivation of AKT/PKB and down-regulation of IAPs and activation of intrinsic apoptotic pathway via generation of Reactive Oxygen Species (ROS).	Curcumin	67-75	AKT serine/threonine kinase 1	Homo sapiens	153-160
31196210-8	2019	Combination treatment with curcumin and gefitinib markedly downregulated EGFR activity through suppressing Sp1 and blocking interaction of Sp1 and HADC1, and markedly suppressed receptor tyrosine kinases as well as ERK/MEK and AKT/S6K pathways in the resistant NSCLC cells.	Curcumin	27-35	epidermal growth factor receptor	Homo sapiens	73-77
31196210-8	2019	Combination treatment with curcumin and gefitinib markedly downregulated EGFR activity through suppressing Sp1 and blocking interaction of Sp1 and HADC1, and markedly suppressed receptor tyrosine kinases as well as ERK/MEK and AKT/S6K pathways in the resistant NSCLC cells.	Curcumin	27-35	mitogen-activated protein kinase kinase 7	Homo sapiens	219-222
31196210-8	2019	Combination treatment with curcumin and gefitinib markedly downregulated EGFR activity through suppressing Sp1 and blocking interaction of Sp1 and HADC1, and markedly suppressed receptor tyrosine kinases as well as ERK/MEK and AKT/S6K pathways in the resistant NSCLC cells.	Curcumin	27-35	AKT serine/threonine kinase 1	Homo sapiens	227-230
31196210-12	2019	Curcumin can be used as a sensitizer to enhance the efficacy of EGFR-TKIs and overcome the EGFR-TKI resistance in NSCLC patients with wild-type EGFR and/or KRAS mutation.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	64-68
31196210-12	2019	Curcumin can be used as a sensitizer to enhance the efficacy of EGFR-TKIs and overcome the EGFR-TKI resistance in NSCLC patients with wild-type EGFR and/or KRAS mutation.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	91-95
31196210-12	2019	Curcumin can be used as a sensitizer to enhance the efficacy of EGFR-TKIs and overcome the EGFR-TKI resistance in NSCLC patients with wild-type EGFR and/or KRAS mutation.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	91-95
30484020-0	2019	Curcumin Reverses 5-Fluorouracil Resistance by Promoting Human Colon Cancer HCT-8/5-FU Cell Apoptosis and Down-regulating Heat Shock Protein 27 and P-Glycoprotein.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	148-162
31249528-8	2019	Conclusions: Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR.	Curcumin	41-49	adiponectin, C1Q and collagen domain containing	Homo sapiens	224-235
31244665-0	2019	Curcumin/Liposome Nanotechnology as Delivery Platform for Anti-inflammatory Activities via NFkB/ERK/pERK Pathway in Human Dental Pulp Treated With 2-HydroxyEthyl MethAcrylate (HEMA).	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	96-99
31214247-9	2019	Curcumin is an effective medicinal agent, as it regulates several important molecular signaling pathways that modulate survival, govern anti-oxidative properties like nuclear factor E2-related factor 2 (Nrf2) and inflammation pathways, e.g., nuclear factor kappa B (NF-kappaB).	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	167-201
31214247-9	2019	Curcumin is an effective medicinal agent, as it regulates several important molecular signaling pathways that modulate survival, govern anti-oxidative properties like nuclear factor E2-related factor 2 (Nrf2) and inflammation pathways, e.g., nuclear factor kappa B (NF-kappaB).	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	203-207
31214247-9	2019	Curcumin is an effective medicinal agent, as it regulates several important molecular signaling pathways that modulate survival, govern anti-oxidative properties like nuclear factor E2-related factor 2 (Nrf2) and inflammation pathways, e.g., nuclear factor kappa B (NF-kappaB).	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	242-264
31214247-9	2019	Curcumin is an effective medicinal agent, as it regulates several important molecular signaling pathways that modulate survival, govern anti-oxidative properties like nuclear factor E2-related factor 2 (Nrf2) and inflammation pathways, e.g., nuclear factor kappa B (NF-kappaB).	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	266-275
31214247-11	2019	Moreover, the disruption of 26S proteasome activity induced by curcumin through inhibiting DYRK2 in different cancerous cells resulting in the inhibition of cell proliferation opens up a new horizon for using curcumin as a potential preventive and treatment approach in proteasome-linked cancers.	Curcumin	63-71	dual specificity tyrosine phosphorylation regulated kinase 2	Homo sapiens	91-96
31214247-11	2019	Moreover, the disruption of 26S proteasome activity induced by curcumin through inhibiting DYRK2 in different cancerous cells resulting in the inhibition of cell proliferation opens up a new horizon for using curcumin as a potential preventive and treatment approach in proteasome-linked cancers.	Curcumin	209-217	dual specificity tyrosine phosphorylation regulated kinase 2	Homo sapiens	91-96
31006841-0	2019	Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	77-80
31006841-0	2019	Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	81-85
31006841-12	2019	CONCLUSIONS: Curcumin can induce protective autophagy of human ovarian cancer cells by inhibiting the AKT/mTOR/p70S6K pathway, indicating the synergistic effects of curcumin and autophagy inhibition as a possible strategy to overcome the limits of current therapies in the eradication of epithelial ovarian cancer.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	102-105
31006841-12	2019	CONCLUSIONS: Curcumin can induce protective autophagy of human ovarian cancer cells by inhibiting the AKT/mTOR/p70S6K pathway, indicating the synergistic effects of curcumin and autophagy inhibition as a possible strategy to overcome the limits of current therapies in the eradication of epithelial ovarian cancer.	Curcumin	13-21	mechanistic target of rapamycin kinase	Homo sapiens	106-110
31145652-7	2019	Then, we identified that curcumin upregulated the expression of self-renewal genes, Notch1 and Hes1, and augmentation of CDK4, Cyclin D1, NICD, and Hes1 protein.	Curcumin	25-33	cyclin-dependent kinase 4	Mus musculus	121-125
30484020-15	2019	Down-regulation of P-gp and HSP-27 may be the mechanism of curcumin reversing the drug resistance of HCT-8/5-FU to 5-FU.	Curcumin	59-67	ATP binding cassette subfamily B member 1	Homo sapiens	19-23
30941633-7	2019	METHODS: The possible cytotoxic and DNA damaging effects of boron nitride nanotubes and curcumin on CD34+ cells, HeLa and V79 cells were evaluated by MTT assay and Comet assay, respectively.	Curcumin	88-96	CD34 molecule	Homo sapiens	100-104
30878804-0	2019	Supramolecular nanoassembly of lysozyme and alpha-lactalbumin (apo alpha-LA) exhibits selective cytotoxicity and enhanced bioavailability of curcumin to cancer cells.	Curcumin	141-149	lactalbumin, alpha	Mus musculus	44-61
30875026-11	2019	A curcumin nanoformulation sized 77 nm and containing of 3% ethanol was more effective in increasing beta1-integrin gene over-expression, anti-apoptosis of fibroblast cells (Bcl2/Bax ratio), and in decreasing Bax and NFkappaB gene expression than that with a particle size of 50 nm.	Curcumin	2-10	BCL2 apoptosis regulator	Homo sapiens	174-178
30875026-11	2019	A curcumin nanoformulation sized 77 nm and containing of 3% ethanol was more effective in increasing beta1-integrin gene over-expression, anti-apoptosis of fibroblast cells (Bcl2/Bax ratio), and in decreasing Bax and NFkappaB gene expression than that with a particle size of 50 nm.	Curcumin	2-10	BCL2 associated X, apoptosis regulator	Homo sapiens	179-182
30875026-11	2019	A curcumin nanoformulation sized 77 nm and containing of 3% ethanol was more effective in increasing beta1-integrin gene over-expression, anti-apoptosis of fibroblast cells (Bcl2/Bax ratio), and in decreasing Bax and NFkappaB gene expression than that with a particle size of 50 nm.	Curcumin	2-10	BCL2 associated X, apoptosis regulator	Homo sapiens	209-212
30875026-11	2019	A curcumin nanoformulation sized 77 nm and containing of 3% ethanol was more effective in increasing beta1-integrin gene over-expression, anti-apoptosis of fibroblast cells (Bcl2/Bax ratio), and in decreasing Bax and NFkappaB gene expression than that with a particle size of 50 nm.	Curcumin	2-10	nuclear factor kappa B subunit 1	Homo sapiens	217-225
30918132-1	2019	Previous studies implicated the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) pathway in renal fibrosis and found that curcumin could suppress the expression of mTOR.	Curcumin	197-205	mechanistic target of rapamycin kinase	Homo sapiens	32-61
30918132-1	2019	Previous studies implicated the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) pathway in renal fibrosis and found that curcumin could suppress the expression of mTOR.	Curcumin	197-205	mechanistic target of rapamycin kinase	Homo sapiens	63-67
30918132-1	2019	Previous studies implicated the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) pathway in renal fibrosis and found that curcumin could suppress the expression of mTOR.	Curcumin	197-205	hypoxia inducible factor 1 subunit alpha	Homo sapiens	69-100
30941633-8	2019	RESULTS AND CONCLUSION: Boron nitride nanotubes and curcumin had cytotoxic effects and cause DNA damage on CD34+ cells, HeLa and V79 cells at several concentrations, probably because of increased ROS level.	Curcumin	52-60	CD34 molecule	Homo sapiens	107-111
30918132-1	2019	Previous studies implicated the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) pathway in renal fibrosis and found that curcumin could suppress the expression of mTOR.	Curcumin	197-205	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-112
30918132-1	2019	Previous studies implicated the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) pathway in renal fibrosis and found that curcumin could suppress the expression of mTOR.	Curcumin	197-205	vascular endothelial growth factor A	Homo sapiens	114-148
31240898-5	2019	Amyloid-beta plaques were identified based on the fluorescence of curcumin, and coregistered morphological images of the brain tissue were provided by the OCM channel.	Curcumin	66-74	amyloid beta precursor protein	Homo sapiens	0-12
30918132-1	2019	Previous studies implicated the mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) pathway in renal fibrosis and found that curcumin could suppress the expression of mTOR.	Curcumin	197-205	vascular endothelial growth factor A	Homo sapiens	150-154
30802519-0	2019	Aptamer functionalized curcumin-loaded human serum albumin (HSA) nanoparticles for targeted delivery to HER-2 positive breast cancer cells.	Curcumin	23-31	albumin	Homo sapiens	45-58
30802519-0	2019	Aptamer functionalized curcumin-loaded human serum albumin (HSA) nanoparticles for targeted delivery to HER-2 positive breast cancer cells.	Curcumin	23-31	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-109
30802519-1	2019	In this study, an HER2 aptamer-decorated curcumin-loaded human serum albumin nanoparticle (Apt-HSA/CCM NP) was developed and characterized as a new anticancer formulation for targeted delivery to human epithelial growth factor receptor 2 (HER2) overexpressing breast cancer cells.	Curcumin	41-49	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-22
30802519-1	2019	In this study, an HER2 aptamer-decorated curcumin-loaded human serum albumin nanoparticle (Apt-HSA/CCM NP) was developed and characterized as a new anticancer formulation for targeted delivery to human epithelial growth factor receptor 2 (HER2) overexpressing breast cancer cells.	Curcumin	41-49	albumin	Homo sapiens	63-76
30802519-1	2019	In this study, an HER2 aptamer-decorated curcumin-loaded human serum albumin nanoparticle (Apt-HSA/CCM NP) was developed and characterized as a new anticancer formulation for targeted delivery to human epithelial growth factor receptor 2 (HER2) overexpressing breast cancer cells.	Curcumin	41-49	erb-b2 receptor tyrosine kinase 2	Homo sapiens	239-243
30793463-0	2019	Curcumin-galactomannosides mitigate alcohol-induced liver damage by inhibiting oxidative stress, hepatic inflammation, and enhance bioavailability on TLR4/MMP events compared to curcumin.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	150-154
31204416-0	2019	Effect of Phytosomal Curcumin on Circulating Levels of Adiponectin and Leptin in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.	Curcumin	21-29	adiponectin, C1Q and collagen domain containing	Homo sapiens	55-66
31204416-2	2019	The aim of the current study was to evaluate the effect of phytosomal curcumin on serum adiponectin and leptin levels in patients with NAFLD.	Curcumin	70-78	adiponectin, C1Q and collagen domain containing	Homo sapiens	88-99
31204416-6	2019	Serum adiponectin levels increased significantly (p&lt;0.001) and serum leptin levels decreased significantly (p&lt;0.001) with a decrease in the leptin: adiponectin ratio in the curcumin group compared to the placebo group after 8 weeks of intervention.	Curcumin	179-187	adiponectin, C1Q and collagen domain containing	Homo sapiens	154-165
31204416-8	2019	Phytosomal curcumin effectively improved leptin and adiponectin levels.	Curcumin	11-19	adiponectin, C1Q and collagen domain containing	Homo sapiens	52-63
31149032-0	2019	The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes: a randomized, double-blind clinical trial.	Curcumin	14-22	insulin	Homo sapiens	66-73
31489409-0	2019	[Effects of curcumin on EZH2 mRNA expression in the mandible and femur of ovariectomized osteoporosis rats].	Curcumin	12-20	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	24-28
31489409-1	2019	PURPOSE: To study the effects of curcumin on EZH2 mRNA expression in the mandible and femur of ovariectomized osteoporosis rats,and to investigate its protective effect and mechanism.	Curcumin	33-41	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	45-49
31489409-10	2019	Compared with the OVX group,curcumin increased BMD and improved bone microstructure, decreased serum contents of alkaline phosphatase,and down-regulated the expression levels of EZH2mRNA in bone tissues of rats with osteoporosis (P&lt;0.05).	Curcumin	28-36	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	178-182
30511344-12	2019	The ganoderic acid A and curcumin were the best-docked among different compounds and exhibits downregulation in Notch-1 mRNA expression and inhibits proliferation, viability, and ROS activity in IMR-32 cells.	Curcumin	25-33	notch receptor 1	Homo sapiens	112-119
30972855-8	2019	Curcumin inhibited the LPS-induced up-regulation of PIC with strong down-regulation of IL-8.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Bos taurus	87-91
30990213-2	2019	We previously demonstrated that the combination of phytosterols (PS) and curcumin administered as dietary supplements significantly lowers LDL-cholesterol (LDL-C) more than either treatment alone.	Curcumin	73-81	component of oligomeric golgi complex 2	Homo sapiens	156-161
30935902-0	2019	Effects of curcumin and its adjuvant on TPC1 thyroid cell line.	Curcumin	11-19	two pore segment channel 1	Homo sapiens	40-44
30935902-6	2019	The inhibitory effect of curcumin, piperine and vitamin E on cell proliferation involves different markers, and in particular inhibits beta-catenin, cyclinD1 and p53, making them candidates for a possible use in alternative therapies although further studies are needed.	Curcumin	25-33	tumor protein p53	Homo sapiens	162-165
30946834-0	2019	Curcumin analogues attenuate Abeta25-35-induced oxidative stress in PC12 cells via Keap1/Nrf2/HO-1 signaling pathways.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	89-93
31112588-0	2019	Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	124-128
31143210-13	2019	Real-time RT-PCR and western blot revealed that, compared to the 4.25% Dianeal treated cells, curcumin treatment resulted in increased expression of E-cadherin (epithelial marker), and decreased expression of alpha-SMA (mesenchymal markers) (P &lt; 0.05).	Curcumin	94-102	cadherin 1	Homo sapiens	149-159
31143210-14	2019	Furthermore, curcumin reduced mRNA expression of two extracellular matrix protein, collagen I and fibronectin.	Curcumin	13-21	fibronectin 1	Homo sapiens	83-109
31143210-15	2019	Curcumin also reduced TGF-beta1 mRNA and supernatant TGF-beta1 protein content in the PDS-treated HMrSV5 cells (P &lt; 0.05).	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	22-31
31143210-15	2019	Curcumin also reduced TGF-beta1 mRNA and supernatant TGF-beta1 protein content in the PDS-treated HMrSV5 cells (P &lt; 0.05).	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	53-62
31143210-17	2019	Conclusions: Our results demonstrate that curcumin showed an obvious protective effect on PDS-induced EMT of HMrSV5 cells and suggest implication of the TAK1, p38 and JNK pathway in mediating the effects of curcumin in EMT of MCs.	Curcumin	42-50	mitogen-activated protein kinase 14	Homo sapiens	159-162
31143210-17	2019	Conclusions: Our results demonstrate that curcumin showed an obvious protective effect on PDS-induced EMT of HMrSV5 cells and suggest implication of the TAK1, p38 and JNK pathway in mediating the effects of curcumin in EMT of MCs.	Curcumin	42-50	mitogen-activated protein kinase 8	Homo sapiens	167-170
31143210-17	2019	Conclusions: Our results demonstrate that curcumin showed an obvious protective effect on PDS-induced EMT of HMrSV5 cells and suggest implication of the TAK1, p38 and JNK pathway in mediating the effects of curcumin in EMT of MCs.	Curcumin	207-215	mitogen-activated protein kinase 8	Homo sapiens	167-170
31112588-8	2019	The effect of curcumin on Nrf2-Keap1 signaling pathway-related genes was analyzed by qRT-PCR.	Curcumin	14-22	nuclear factor, erythroid derived 2, like 2	Mus musculus	26-30
31112588-13	2019	Furthermore, middle-dose curcumin upregulated Nrf2 expression after H2O2 treatment for 4 h. Low- and middle-dose curcumin could activate Nrf2 and promote it to migrate into nuclei.	Curcumin	25-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	46-50
31112588-13	2019	Furthermore, middle-dose curcumin upregulated Nrf2 expression after H2O2 treatment for 4 h. Low- and middle-dose curcumin could activate Nrf2 and promote it to migrate into nuclei.	Curcumin	25-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	137-141
31112588-13	2019	Furthermore, middle-dose curcumin upregulated Nrf2 expression after H2O2 treatment for 4 h. Low- and middle-dose curcumin could activate Nrf2 and promote it to migrate into nuclei.	Curcumin	113-121	nuclear factor, erythroid derived 2, like 2	Mus musculus	46-50
31112588-13	2019	Furthermore, middle-dose curcumin upregulated Nrf2 expression after H2O2 treatment for 4 h. Low- and middle-dose curcumin could activate Nrf2 and promote it to migrate into nuclei.	Curcumin	113-121	nuclear factor, erythroid derived 2, like 2	Mus musculus	137-141
31112588-14	2019	The translocation of Nrf2 to the nucleus to upregulate the expression of haemoxygenase-1 (HO-1) was promoted in the low- and middle-dose curcumin-treated groups.	Curcumin	137-145	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
31112588-14	2019	The translocation of Nrf2 to the nucleus to upregulate the expression of haemoxygenase-1 (HO-1) was promoted in the low- and middle-dose curcumin-treated groups.	Curcumin	137-145	heme oxygenase 1	Mus musculus	73-94
31112588-16	2019	Curcumin resisted oxidants by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway, which could potentially promote cell survival.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-100
31092832-0	2019	Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFkB/AKT/mTOR/KEAP1 signalling in rat heart.	Curcumin	41-49	NFE2 like bZIP transcription factor 2	Rattus norvegicus	23-27
30642508-6	2019	The highest curcumin loading capacities were 11.53 and 9.89 mg/g protein (with a final curcumin concentration of 312.5 muM and 268 muM respectively), at pH 3.0 and 3.8, respectively.	Curcumin	12-20	latexin	Homo sapiens	119-122
30642508-6	2019	The highest curcumin loading capacities were 11.53 and 9.89 mg/g protein (with a final curcumin concentration of 312.5 muM and 268 muM respectively), at pH 3.0 and 3.8, respectively.	Curcumin	12-20	latexin	Homo sapiens	131-134
31096703-0	2019	Natural Dietary Supplementation of Curcumin Protects Mice Brains against Ethanol-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment via Nrf2/TLR4/RAGE Signaling.	Curcumin	35-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	159-163
31096703-0	2019	Natural Dietary Supplementation of Curcumin Protects Mice Brains against Ethanol-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment via Nrf2/TLR4/RAGE Signaling.	Curcumin	35-43	toll-like receptor 4	Mus musculus	164-168
31096703-0	2019	Natural Dietary Supplementation of Curcumin Protects Mice Brains against Ethanol-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment via Nrf2/TLR4/RAGE Signaling.	Curcumin	35-43	advanced glycosylation end product-specific receptor	Mus musculus	169-173
31096703-2	2019	According to our findings, ethanol triggered reactive oxygen species (ROS), apoptosis, neuroinflammation, and memory impairment, which were significantly inhibited with the administration of curcumin, as assessed by ROS, lipid peroxidation (LPO), and Nrf2/HO-1 (nuclear factor erythroid 2-related factor 2/Heme-oxygenase-1) expression in the experimental mice brains.	Curcumin	191-199	nuclear factor, erythroid derived 2, like 2	Mus musculus	251-255
31096703-2	2019	According to our findings, ethanol triggered reactive oxygen species (ROS), apoptosis, neuroinflammation, and memory impairment, which were significantly inhibited with the administration of curcumin, as assessed by ROS, lipid peroxidation (LPO), and Nrf2/HO-1 (nuclear factor erythroid 2-related factor 2/Heme-oxygenase-1) expression in the experimental mice brains.	Curcumin	191-199	heme oxygenase 1	Mus musculus	256-260
31096703-2	2019	According to our findings, ethanol triggered reactive oxygen species (ROS), apoptosis, neuroinflammation, and memory impairment, which were significantly inhibited with the administration of curcumin, as assessed by ROS, lipid peroxidation (LPO), and Nrf2/HO-1 (nuclear factor erythroid 2-related factor 2/Heme-oxygenase-1) expression in the experimental mice brains.	Curcumin	191-199	nuclear factor, erythroid derived 2, like 2	Mus musculus	262-305
31092832-0	2019	Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFkB/AKT/mTOR/KEAP1 signalling in rat heart.	Curcumin	41-49	AKT serine/threonine kinase 1	Rattus norvegicus	116-119
31096703-2	2019	According to our findings, ethanol triggered reactive oxygen species (ROS), apoptosis, neuroinflammation, and memory impairment, which were significantly inhibited with the administration of curcumin, as assessed by ROS, lipid peroxidation (LPO), and Nrf2/HO-1 (nuclear factor erythroid 2-related factor 2/Heme-oxygenase-1) expression in the experimental mice brains.	Curcumin	191-199	heme oxygenase 1	Mus musculus	306-322
31096703-3	2019	Moreover, curcumin regulated the expression of the glial cell markers in ethanol-treated mice brains, as analyzed by the relative expression TLR4 (Toll like Receptor 4), RAGE (Receptor for Advanced Glycations End products), GFAP (Glial fibrillary acidic protein), and Iba-1 (Ionized calcium binding adaptor molecule 1), through Western blot and confocal microscopic analysis.	Curcumin	10-18	toll-like receptor 4	Mus musculus	141-145
31092832-2	2019	In the present study an attempt has been made to elucidate possible interaction between vitamin E or/and curcumin (two established antioxidants) with active portion (redox signaling intervening region) of nuclear factor erythroid 2-related factor 2 (NRF2) as a mechanism to alleviate oxidative stress in rat heart under altered thyroid states.	Curcumin	105-113	NFE2 like bZIP transcription factor 2	Rattus norvegicus	205-248
31096703-3	2019	Moreover, curcumin regulated the expression of the glial cell markers in ethanol-treated mice brains, as analyzed by the relative expression TLR4 (Toll like Receptor 4), RAGE (Receptor for Advanced Glycations End products), GFAP (Glial fibrillary acidic protein), and Iba-1 (Ionized calcium binding adaptor molecule 1), through Western blot and confocal microscopic analysis.	Curcumin	10-18	toll-like receptor 4	Mus musculus	147-167
31096703-3	2019	Moreover, curcumin regulated the expression of the glial cell markers in ethanol-treated mice brains, as analyzed by the relative expression TLR4 (Toll like Receptor 4), RAGE (Receptor for Advanced Glycations End products), GFAP (Glial fibrillary acidic protein), and Iba-1 (Ionized calcium binding adaptor molecule 1), through Western blot and confocal microscopic analysis.	Curcumin	10-18	advanced glycosylation end product-specific receptor	Mus musculus	170-174
31096703-3	2019	Moreover, curcumin regulated the expression of the glial cell markers in ethanol-treated mice brains, as analyzed by the relative expression TLR4 (Toll like Receptor 4), RAGE (Receptor for Advanced Glycations End products), GFAP (Glial fibrillary acidic protein), and Iba-1 (Ionized calcium binding adaptor molecule 1), through Western blot and confocal microscopic analysis.	Curcumin	10-18	advanced glycosylation end product-specific receptor	Mus musculus	176-221
31092832-2	2019	In the present study an attempt has been made to elucidate possible interaction between vitamin E or/and curcumin (two established antioxidants) with active portion (redox signaling intervening region) of nuclear factor erythroid 2-related factor 2 (NRF2) as a mechanism to alleviate oxidative stress in rat heart under altered thyroid states.	Curcumin	105-113	NFE2 like bZIP transcription factor 2	Rattus norvegicus	250-254
31092832-7	2019	Co-administration of vitamin E and curcumin showed better result in attenuating expression of mammalian target for rapamycin (mTOR), restoration of total protein content and biological activity of Ca2+ ATPase in hyperthyroid rats, whereas, their individual treatment showed partial restoration.	Curcumin	35-43	mechanistic target of rapamycin kinase	Homo sapiens	94-124
31092832-7	2019	Co-administration of vitamin E and curcumin showed better result in attenuating expression of mammalian target for rapamycin (mTOR), restoration of total protein content and biological activity of Ca2+ ATPase in hyperthyroid rats, whereas, their individual treatment showed partial restoration.	Curcumin	35-43	mechanistic target of rapamycin kinase	Homo sapiens	126-130
31092832-9	2019	For the first time, a modeled active portion of the zipped protein NRF2 indicated its interaction with both vitamin E and curcumin.	Curcumin	122-130	NFE2 like bZIP transcription factor 2	Rattus norvegicus	67-71
31092832-11	2019	Reduction of oxidative stress by curcumin and/or vitamin E may be due to modulation of NRF2 and KEAP1 function in rat heart under altered thyroid states.	Curcumin	33-41	NFE2 like bZIP transcription factor 2	Rattus norvegicus	87-91
31091659-6	2019	Curcumin treatment or GR mildly inhibited Na+/H+ exchanger-1 (NHE1).	Curcumin	0-8	solute carrier family 9 member A1	Homo sapiens	42-60
31223428-0	2019	Curcumin Inhibits the PERK-eIF2alpha-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model.	Curcumin	0-8	sirtuin 1	Rattus norvegicus	68-73
31223428-5	2019	Curcumin inhibited the expression of cleaved caspase3, cleaved poly (ADP-ribose) polymerase (PARP), C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the chondroprotective protein Bcl2 in TBHP-treated chondrocytes.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	219-223
31223428-6	2019	In addition, curcumin promoted the expression of silent information regulator factor 2-related enzyme 1 (SIRT1) and suppressed the expression of activating transcription factor 4 (ATF4), the ratio of p-PERK/PERK, p-eIF2alpha/eIF2alpha.	Curcumin	13-21	sirtuin 1	Rattus norvegicus	49-103
31223428-6	2019	In addition, curcumin promoted the expression of silent information regulator factor 2-related enzyme 1 (SIRT1) and suppressed the expression of activating transcription factor 4 (ATF4), the ratio of p-PERK/PERK, p-eIF2alpha/eIF2alpha.	Curcumin	13-21	sirtuin 1	Rattus norvegicus	105-110
31223428-6	2019	In addition, curcumin promoted the expression of silent information regulator factor 2-related enzyme 1 (SIRT1) and suppressed the expression of activating transcription factor 4 (ATF4), the ratio of p-PERK/PERK, p-eIF2alpha/eIF2alpha.	Curcumin	13-21	activating transcription factor 4	Rattus norvegicus	145-178
31223428-6	2019	In addition, curcumin promoted the expression of silent information regulator factor 2-related enzyme 1 (SIRT1) and suppressed the expression of activating transcription factor 4 (ATF4), the ratio of p-PERK/PERK, p-eIF2alpha/eIF2alpha.	Curcumin	13-21	activating transcription factor 4	Rattus norvegicus	180-184
31223428-8	2019	By applying immunohistochemical analysis, we found that curcumin enhanced the expression of SIRT1 and inhibited the expression of CHOP and cleaved caspase3 in ACLT rats.	Curcumin	56-64	sirtuin 1	Rattus norvegicus	92-97
31223428-9	2019	Taken together, our present findings firstly indicate that curcumin could inhibit the PERK-eIF2alpha-CHOP axis of the ER stress response through the activation of SIRT1 in tert-Butyl hydroperoxide- (TBHP-) treated rat chondrocytes and ameliorated osteoarthritis development in vivo.	Curcumin	59-67	sirtuin 1	Rattus norvegicus	163-168
31091659-6	2019	Curcumin treatment or GR mildly inhibited Na+/H+ exchanger-1 (NHE1).	Curcumin	0-8	solute carrier family 9 member A1	Homo sapiens	62-66
31091659-10	2019	Modeling of mTOR protein revealed structural changes upon treatments, and curcumin plus GR decreased binding of Raptor and GbetaL to mTOR, as well as of Rag A and Rag B to Raptor.	Curcumin	74-82	MTOR associated protein, LST8 homolog	Homo sapiens	123-129
31091659-10	2019	Modeling of mTOR protein revealed structural changes upon treatments, and curcumin plus GR decreased binding of Raptor and GbetaL to mTOR, as well as of Rag A and Rag B to Raptor.	Curcumin	74-82	mechanistic target of rapamycin kinase	Homo sapiens	133-137
33405778-4	2019	The multifunctional nanocarriers were loaded with the plant-derived anticancer drug curcumin, and in vitro analyses revealed that their cytotoxic, apoptogenic, and NF-kappaB-inhibitory effects on target cells were superior over those of the free drug and non-functionalized polymer micelles of similar composition.	Curcumin	84-92	nuclear factor kappa B subunit 1	Homo sapiens	164-173
31190861-0	2019	The reversal of MRP1 expression induced by low-frequency and low-intensity ultrasound and curcumin mediated by VEGF in brain glioma.	Curcumin	90-98	ATP binding cassette subfamily B member 1	Homo sapiens	16-20
30926313-6	2019	The use of curcumin-nanoemulsion associated with photodynamic therapy resulted in an increase in the levels of caspase 3/7 activity for the studied MCF-7 cell model, indicating that this therapy triggers a cascade of events that lead to cell death, such as cellular apoptosis.	Curcumin	11-19	caspase 3	Homo sapiens	111-122
31190861-0	2019	The reversal of MRP1 expression induced by low-frequency and low-intensity ultrasound and curcumin mediated by VEGF in brain glioma.	Curcumin	90-98	vascular endothelial growth factor A	Homo sapiens	111-115
31190861-1	2019	Purpose: To explore the effect of curcumin and low-frequency and low-intensity ultrasound (LFLIU) on C6 and U87 cell, and whether LFLIU could inhibit multidrug resistance protein 1 (MRP1) by increasing the sensitivity of curcumin via vascular epithelial growth factor (VEGF)/PI3K/Akt signaling pathway targeting.	Curcumin	221-229	ATP binding cassette subfamily B member 1	Homo sapiens	182-186
31190861-7	2019	VEGF and MRP1 were highly expressed in C6 and U87 cells, curcumin and LFLIU alone or in combination could decrease the expression of both VEGF and MRP1.	Curcumin	57-65	vascular endothelial growth factor A	Homo sapiens	0-4
31190861-7	2019	VEGF and MRP1 were highly expressed in C6 and U87 cells, curcumin and LFLIU alone or in combination could decrease the expression of both VEGF and MRP1.	Curcumin	57-65	ATP binding cassette subfamily B member 1	Homo sapiens	9-13
31190861-7	2019	VEGF and MRP1 were highly expressed in C6 and U87 cells, curcumin and LFLIU alone or in combination could decrease the expression of both VEGF and MRP1.	Curcumin	57-65	vascular endothelial growth factor A	Homo sapiens	138-142
31190861-7	2019	VEGF and MRP1 were highly expressed in C6 and U87 cells, curcumin and LFLIU alone or in combination could decrease the expression of both VEGF and MRP1.	Curcumin	57-65	ATP binding cassette subfamily B member 1	Homo sapiens	147-151
31190861-9	2019	Conclusion: The synergistic effects, such as a higher inhibition rate, and lower expressions of MRP1 and VEGF, of combined curcumin and LFLIU against glioma was much better than that of a single treatment.	Curcumin	123-131	ATP binding cassette subfamily B member 1	Homo sapiens	96-100
31190861-9	2019	Conclusion: The synergistic effects, such as a higher inhibition rate, and lower expressions of MRP1 and VEGF, of combined curcumin and LFLIU against glioma was much better than that of a single treatment.	Curcumin	123-131	vascular endothelial growth factor A	Homo sapiens	105-109
31223280-7	2019	The anticancer effects of curcumin are mainly mediated through its regulation of multiple cellular signaling pathways, including Wnt/beta-catenin, PI3K/Akt, JAK/STAT, MAPK, p53 and NF-kB signaling pathways.	Curcumin	26-34	AKT serine/threonine kinase 1	Homo sapiens	152-155
31223280-7	2019	The anticancer effects of curcumin are mainly mediated through its regulation of multiple cellular signaling pathways, including Wnt/beta-catenin, PI3K/Akt, JAK/STAT, MAPK, p53 and NF-kB signaling pathways.	Curcumin	26-34	tumor protein p53	Homo sapiens	173-176
30988750-11	2019	The PaCO2, serum Smad4, Smurf2 and IL-4 in the curcumin group were lower than those in the paraquat group (P&lt;0.05).	Curcumin	47-55	SMAD specific E3 ubiquitin protein ligase 2	Rattus norvegicus	24-30
30663793-0	2019	Curcumin reduces inflammation in knee osteoarthritis rats through blocking TLR4 /MyD88/NF-kappaB signal pathway.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	75-79
30663793-10	2019	The expression of synovial fluid inflammatory biomarkers, IL-6, IL-1beta, and TNF-alpha in the OA + curcumin group were lower than that in OA and OA + PBS group.	Curcumin	100-108	tumor necrosis factor	Rattus norvegicus	78-87
30663793-11	2019	The protein expression of the TLR4 receptor was increased in the OA, OA + PBS, and OA + curcumin group compared to the control group.	Curcumin	88-96	toll-like receptor 4	Rattus norvegicus	30-34
30663793-12	2019	However, curcumin treatment can significantly decrease the expression of MyD88, p-IkappaBalpha, NF-kappaB, TNF-alpha, IL-1beta, and IL6 in OA + curcumin group.	Curcumin	9-17	tumor necrosis factor	Rattus norvegicus	107-116
30663793-12	2019	However, curcumin treatment can significantly decrease the expression of MyD88, p-IkappaBalpha, NF-kappaB, TNF-alpha, IL-1beta, and IL6 in OA + curcumin group.	Curcumin	9-17	interleukin 1 alpha	Rattus norvegicus	118-126
30663793-12	2019	However, curcumin treatment can significantly decrease the expression of MyD88, p-IkappaBalpha, NF-kappaB, TNF-alpha, IL-1beta, and IL6 in OA + curcumin group.	Curcumin	9-17	interleukin 6	Rattus norvegicus	132-135
30663793-12	2019	However, curcumin treatment can significantly decrease the expression of MyD88, p-IkappaBalpha, NF-kappaB, TNF-alpha, IL-1beta, and IL6 in OA + curcumin group.	Curcumin	144-152	tumor necrosis factor	Rattus norvegicus	107-116
30663793-12	2019	However, curcumin treatment can significantly decrease the expression of MyD88, p-IkappaBalpha, NF-kappaB, TNF-alpha, IL-1beta, and IL6 in OA + curcumin group.	Curcumin	144-152	interleukin 6	Rattus norvegicus	132-135
30663793-13	2019	These findings may indicate that curcumin could block TLR4/NF-kappaB signal pathway, and reduce inflammation level to prevent knee wound in OA rats.	Curcumin	33-41	toll-like receptor 4	Rattus norvegicus	54-58
30988793-5	2019	Morphological changes, the expression levels of the bone-associated gene markers bone morphogenetic protein 2, runt-related transcription factor and osterix during differentiation, an in vitro mineralization assay, and changes in osteocalcin expression revealed that curcumin supplementation promoted the osteogenic differentiation of BMSCs.	Curcumin	267-275	bone morphogenetic protein 2	Mus musculus	81-109
30446932-9	2019	CONCLUSIONS: Curcumin is effective in lowering LDL-C, triglycerides, FBS, HOMA-IR, weight, and AST levels in NAFLD patients, and it is well tolerated.	Curcumin	13-21	solute carrier family 17 member 5	Homo sapiens	95-98
30988750-9	2019	The artery blood PaCO2, serum Smad4, Smurf2 and IL-4 in the curcumin group were significantly lower on day 1 than those on day 5 (P&lt;0.05).	Curcumin	60-68	SMAD specific E3 ubiquitin protein ligase 2	Rattus norvegicus	37-43
30317564-9	2019	Curcumin targets various inflammatory mediators such as cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor kappaB (NF-kappaB), thereby attenuating the release of proinflammatory and profibrotic cytokines, and suppressing chronic production of free radicals, which culminates in the amelioration of tissue toxicity.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	56-72
30317564-9	2019	Curcumin targets various inflammatory mediators such as cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor kappaB (NF-kappaB), thereby attenuating the release of proinflammatory and profibrotic cytokines, and suppressing chronic production of free radicals, which culminates in the amelioration of tissue toxicity.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	126-132
30317564-9	2019	Curcumin targets various inflammatory mediators such as cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor kappaB (NF-kappaB), thereby attenuating the release of proinflammatory and profibrotic cytokines, and suppressing chronic production of free radicals, which culminates in the amelioration of tissue toxicity.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	134-143
30317564-10	2019	Through modulation of NF-kappaB and its downstream signaling cascade, curcumin can also reduce angiogenesis, tumor growth, and metastasis.	Curcumin	70-78	nuclear factor kappa B subunit 1	Homo sapiens	22-31
31080349-2	2019	We had first reported that curcumin exhibits hypocholesterolemic properties by improving the apolipoprotein B (apoB) mRNA editing in primary rat hepatocytes.	Curcumin	27-35	apolipoprotein B	Rattus norvegicus	93-109
31080349-2	2019	We had first reported that curcumin exhibits hypocholesterolemic properties by improving the apolipoprotein B (apoB) mRNA editing in primary rat hepatocytes.	Curcumin	27-35	apolipoprotein B	Rattus norvegicus	111-115
31278718-8	2019	Co-treatment with curcumin or taurine with BPA led to reduce in MDA and increased GPx, GST, CAT, SOD activities compared to BPA group.	Curcumin	18-26	catalase	Rattus norvegicus	92-95
30392062-0	2019	Curcumin ameliorates PRMT5-MEP50 arginine methyltransferase expression by decreasing the Sp1 and NF-YA transcription factors in the A549 and MCF-7 cells.	Curcumin	0-8	protein arginine methyltransferase 5	Homo sapiens	21-26
30392062-4	2019	We exposed the lung and breast cancer cell lines (A549 and MCF-7) to curcumin (2 and 20 muM) and observed a highly significant inhibitory effect on the expression of both PRMT5 and MEP50.	Curcumin	69-77	protein arginine methyltransferase 5	Homo sapiens	171-176
30392062-6	2019	We also found that curcumin significantly reduced the level and enrichment of the transcription factors Sp1 and NF-YA which shares their binding sites within the GC-rich region of the PRMT5 proximal promoter.	Curcumin	19-27	protein arginine methyltransferase 5	Homo sapiens	184-189
30392062-7	2019	Furthermore, the involvement of both PKC-p38-ERK-cFos and AKT-mTOR signalling was observed in reducing the Sp1 and NF-YA expression by curcumin.	Curcumin	135-143	mitogen-activated protein kinase 14	Homo sapiens	41-44
30392062-7	2019	Furthermore, the involvement of both PKC-p38-ERK-cFos and AKT-mTOR signalling was observed in reducing the Sp1 and NF-YA expression by curcumin.	Curcumin	135-143	mitogen-activated protein kinase 1	Homo sapiens	45-48
30392062-7	2019	Furthermore, the involvement of both PKC-p38-ERK-cFos and AKT-mTOR signalling was observed in reducing the Sp1 and NF-YA expression by curcumin.	Curcumin	135-143	AKT serine/threonine kinase 1	Homo sapiens	58-61
30392062-7	2019	Furthermore, the involvement of both PKC-p38-ERK-cFos and AKT-mTOR signalling was observed in reducing the Sp1 and NF-YA expression by curcumin.	Curcumin	135-143	mechanistic target of rapamycin kinase	Homo sapiens	62-66
30392062-8	2019	Therefore, we propose curcumin decreased the expression of PRMT5 in these cells by affecting at least these two transcription factors.	Curcumin	22-30	protein arginine methyltransferase 5	Homo sapiens	59-64
30392062-9	2019	Altogether, we report a new molecular target of curcumin and further elucidation of this proposed mechanism through which curcumin affects the PRMT5-MEP50 methyltransferase expression might be explored for its therapeutic application.	Curcumin	48-56	protein arginine methyltransferase 5	Homo sapiens	143-148
30392062-9	2019	Altogether, we report a new molecular target of curcumin and further elucidation of this proposed mechanism through which curcumin affects the PRMT5-MEP50 methyltransferase expression might be explored for its therapeutic application.	Curcumin	122-130	protein arginine methyltransferase 5	Homo sapiens	143-148
30813036-0	2019	Curcumin nanoparticles incorporated collagen-chitosan scaffold promotes cutaneous wound healing through regulation of TGF-beta1/Smad7 gene expression.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	118-127
30813036-0	2019	Curcumin nanoparticles incorporated collagen-chitosan scaffold promotes cutaneous wound healing through regulation of TGF-beta1/Smad7 gene expression.	Curcumin	0-8	SMAD family member 7	Rattus norvegicus	128-133
31005718-12	2019	Moreover, curcumin down-regulated the mRNA expression of Vimentin, Fibronectin, and beta-catenin, and up-regulated E-cadherin mRNA expression levels.	Curcumin	10-18	fibronectin 1	Homo sapiens	67-78
31005718-12	2019	Moreover, curcumin down-regulated the mRNA expression of Vimentin, Fibronectin, and beta-catenin, and up-regulated E-cadherin mRNA expression levels.	Curcumin	10-18	cadherin 1	Homo sapiens	115-125
31551208-6	2019	The expression levels of COX-2 and MMP-9 were both down-regulated by curcumin.	Curcumin	69-77	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	25-30
31183386-9	2019	In addition, carvedilol treatment and the combination of doxazosin with curcumin increased Nrf-2/NF-kappaB mRNA ratio and its protein expression in the inflammatory cells in the livers, possibly as another mechanism of hepatoprotection.	Curcumin	72-80	NFE2 like bZIP transcription factor 2	Homo sapiens	91-96
30864188-0	2019	The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial.	Curcumin	15-23	C-reactive protein	Homo sapiens	60-78
30864188-0	2019	The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial.	Curcumin	15-23	adiponectin, C1Q and collagen domain containing	Homo sapiens	86-97
30864188-8	2019	At the end of study, the mean concentration of high-sensitivity C-reactive protein decreased in the curcumin group compared to the control (2.9 +- 2.9 vs. 3.4 +- 4.2; p &lt; 0.05).	Curcumin	100-108	C-reactive protein	Homo sapiens	64-82
31183386-0	2019	Curcumin and alpha/beta-Adrenergic Antagonists Cotreatment Reverse Liver Cirrhosis in Hamsters: Participation of Nrf-2 and NF-kappaB.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	113-118
31183386-0	2019	Curcumin and alpha/beta-Adrenergic Antagonists Cotreatment Reverse Liver Cirrhosis in Hamsters: Participation of Nrf-2 and NF-kappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	123-132
31183386-8	2019	However, the best effect was the combined effect of doxazosin, carvedilol, and curcumin, reversing liver fibrosis and decreasing the amount of collagen I (Sirius red stain) without affecting the morphology of hepatocytes (hematoxylin and eosin stain), showing normal hepatic function (glucose, albumin, AST, ALT, total bilirubin, and total proteins).	Curcumin	79-87	solute carrier family 17 member 5	Homo sapiens	303-306
31183386-9	2019	In addition, carvedilol treatment and the combination of doxazosin with curcumin increased Nrf-2/NF-kappaB mRNA ratio and its protein expression in the inflammatory cells in the livers, possibly as another mechanism of hepatoprotection.	Curcumin	72-80	nuclear factor kappa B subunit 1	Homo sapiens	97-106
31183386-10	2019	Therefore, these results suggest for the first time that alpha/beta adrenergic blockers with curcumin completely reverse hepatic damage, possibly as a result of adrenergic antagonism on HSC and conceivably by the increase of Nrf-2/NF-kappaB mRNA ratio.	Curcumin	93-101	amyloid beta precursor protein	Homo sapiens	57-67
31183386-10	2019	Therefore, these results suggest for the first time that alpha/beta adrenergic blockers with curcumin completely reverse hepatic damage, possibly as a result of adrenergic antagonism on HSC and conceivably by the increase of Nrf-2/NF-kappaB mRNA ratio.	Curcumin	93-101	amyloid beta precursor protein	Homo sapiens	54-55
31183386-10	2019	Therefore, these results suggest for the first time that alpha/beta adrenergic blockers with curcumin completely reverse hepatic damage, possibly as a result of adrenergic antagonism on HSC and conceivably by the increase of Nrf-2/NF-kappaB mRNA ratio.	Curcumin	93-101	NFE2 like bZIP transcription factor 2	Homo sapiens	225-230
31183386-10	2019	Therefore, these results suggest for the first time that alpha/beta adrenergic blockers with curcumin completely reverse hepatic damage, possibly as a result of adrenergic antagonism on HSC and conceivably by the increase of Nrf-2/NF-kappaB mRNA ratio.	Curcumin	93-101	nuclear factor kappa B subunit 1	Homo sapiens	231-240
31086728-0	2019	A combination of curcumin, vorinostat and silibinin reverses Abeta-induced nerve cell toxicity via activation of AKT-MDM2-p53 pathway.	Curcumin	17-25	AKT serine/threonine kinase 1	Rattus norvegicus	113-116
31027362-8	2019	The phytochemicals like sulforaphane and curcumin that can concurrently target SOX9, AR and Wnt/beta-catenin signaling pathways in PCa may thus be beneficial in the chemoprevention of PCa.	Curcumin	41-49	androgen receptor	Homo sapiens	85-87
30970577-3	2019	In this study, we demonstrate that a combination of curcumin-loaded chitosan/alginate nanoparticles (Cur-CS/Alg NPs) and blue light emitting diodes (LED) light irradiation effectively suppressed the hyperproliferation of tumor necrosis factor-alpha (TNF-alpha)-induced cultured human kerlatinocyte (HaCaT) cells.	Curcumin	52-60	tumor necrosis factor	Homo sapiens	221-248
30999631-1	2019	Death Associated Protein Kinase 1 (DAPK1) is an important signaling kinase mediating the biological effect of multiple natural biomolecules such as IFN-gamma, TNF-alpha, curcumin, etc.	Curcumin	170-178	death associated protein kinase 1	Homo sapiens	0-33
30999631-1	2019	Death Associated Protein Kinase 1 (DAPK1) is an important signaling kinase mediating the biological effect of multiple natural biomolecules such as IFN-gamma, TNF-alpha, curcumin, etc.	Curcumin	170-178	death associated protein kinase 1	Homo sapiens	35-40
30970577-3	2019	In this study, we demonstrate that a combination of curcumin-loaded chitosan/alginate nanoparticles (Cur-CS/Alg NPs) and blue light emitting diodes (LED) light irradiation effectively suppressed the hyperproliferation of tumor necrosis factor-alpha (TNF-alpha)-induced cultured human kerlatinocyte (HaCaT) cells.	Curcumin	52-60	tumor necrosis factor	Homo sapiens	250-259
30987250-0	2019	The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells.	Curcumin	17-25	insulin	Homo sapiens	56-63
30942233-0	2019	Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3beta pathway.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	141-144
30942233-5	2019	Exosomes derived from curcumin-treated (primed) cells (Exo-cur) can better prevent the death of neurons in vitro and in vivo to relieve the symptoms of AD by inhibiting phosphorylation of the Tau protein through activating the AKT/GSK-3beta pathway.	Curcumin	22-30	thymoma viral proto-oncogene 1	Mus musculus	227-230
30987250-6	2019	Insulin signaling is one of the important pathways involved in tumor initiation and progression; therefore, we proposed that the anti-metastatic effect of curcumin may mediate the downregulation of insulin and insulin-like growth factor-1 receptors.	Curcumin	155-163	insulin	Homo sapiens	0-7
30987250-5	2019	Curcumin possesses a regulatory effect on insulin and insulin-like growth factor-1 (IGF-1) receptors and signaling.	Curcumin	0-8	insulin	Homo sapiens	42-49
30987250-6	2019	Insulin signaling is one of the important pathways involved in tumor initiation and progression; therefore, we proposed that the anti-metastatic effect of curcumin may mediate the downregulation of insulin and insulin-like growth factor-1 receptors.	Curcumin	155-163	insulin	Homo sapiens	198-205
30987250-6	2019	Insulin signaling is one of the important pathways involved in tumor initiation and progression; therefore, we proposed that the anti-metastatic effect of curcumin may mediate the downregulation of insulin and insulin-like growth factor-1 receptors.	Curcumin	155-163	insulin like growth factor 1	Homo sapiens	210-238
30987250-5	2019	Curcumin possesses a regulatory effect on insulin and insulin-like growth factor-1 (IGF-1) receptors and signaling.	Curcumin	0-8	insulin like growth factor 1	Homo sapiens	54-82
30987250-10	2019	Results: Our findings showed that curcumin significantly decreased insulin and IGF-1 receptors in addition to MYC expression.	Curcumin	34-42	insulin	Homo sapiens	67-74
30987250-5	2019	Curcumin possesses a regulatory effect on insulin and insulin-like growth factor-1 (IGF-1) receptors and signaling.	Curcumin	0-8	insulin like growth factor 1	Homo sapiens	84-89
30987250-10	2019	Results: Our findings showed that curcumin significantly decreased insulin and IGF-1 receptors in addition to MYC expression.	Curcumin	34-42	insulin like growth factor 1	Homo sapiens	79-84
31062527-10	2019	After temporarily exposure to 10 muM/L curcumin during 6 hours as less invasive concentration and time, fascin expression temporarily decreased at 12 hours (18.4%, p=0.024), and since then recovered.	Curcumin	39-47	latexin	Homo sapiens	33-36
31073274-0	2019	Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARgamma-Dependent NF-kappaB Signaling Pathway In Vivo and In Vitro.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	107-116
31073274-2	2019	Curcumin possessed a potent anti-inflammatory property involved in the PPARgamma-dependent NF-kappaB signaling pathway.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	91-100
31073274-9	2019	We found that OVA-induced airway inflammation and mucus hypersecretion in mice, OVA and IL-4-induced upregulation of MCP-1 and MUC5AC, suppression of PPARgamma, and activation and translocation of NF-kappaB p65 were notably improved by curcumin both in vivo and in vitro.	Curcumin	236-244	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	197-206
31073274-11	2019	Taken together, our results indicate that curcumin attenuated OVA-induced airway inflammation and mucus hypersecretion in mice and suppressed OVA- and IL-4-induced upregulation of MCP-1 and MUC5AC both in vivo and in vitro, most likely through a PPARgamma-dependent NF-kappaB signaling pathway.	Curcumin	42-50	mast cell protease 1	Mus musculus	180-185
31073274-11	2019	Taken together, our results indicate that curcumin attenuated OVA-induced airway inflammation and mucus hypersecretion in mice and suppressed OVA- and IL-4-induced upregulation of MCP-1 and MUC5AC both in vivo and in vitro, most likely through a PPARgamma-dependent NF-kappaB signaling pathway.	Curcumin	42-50	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	190-196
31073274-11	2019	Taken together, our results indicate that curcumin attenuated OVA-induced airway inflammation and mucus hypersecretion in mice and suppressed OVA- and IL-4-induced upregulation of MCP-1 and MUC5AC both in vivo and in vitro, most likely through a PPARgamma-dependent NF-kappaB signaling pathway.	Curcumin	42-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	266-275
31062527-14	2019	CONCLUSION: Curcumin is likely to suppress the fascin expression in GBM cells, and this might be a possible mechanism for anti-migration and anti-invasion effects of Curcumin via inhibition of STAT3 phosphorylation.	Curcumin	12-20	signal transducer and activator of transcription 3	Homo sapiens	193-198
31062527-14	2019	CONCLUSION: Curcumin is likely to suppress the fascin expression in GBM cells, and this might be a possible mechanism for anti-migration and anti-invasion effects of Curcumin via inhibition of STAT3 phosphorylation.	Curcumin	166-174	signal transducer and activator of transcription 3	Homo sapiens	193-198
30694418-9	2019	Here, we demonstrate for the first time that oxidative stress could affect the amyloid-beta phagocytic potential of macrophages and hence by alleviating oxidative stress using curcumin, an anti-oxidant could enhance the amyloid-beta phagocytic efficacy of macrophages of patients with AD and MCI, although the responsiveness to curcumin might depends on the presence or absence of APOEepsilon4 allele.	Curcumin	176-184	amyloid beta precursor protein	Homo sapiens	79-91
30694418-9	2019	Here, we demonstrate for the first time that oxidative stress could affect the amyloid-beta phagocytic potential of macrophages and hence by alleviating oxidative stress using curcumin, an anti-oxidant could enhance the amyloid-beta phagocytic efficacy of macrophages of patients with AD and MCI, although the responsiveness to curcumin might depends on the presence or absence of APOEepsilon4 allele.	Curcumin	176-184	amyloid beta precursor protein	Homo sapiens	220-232
30293230-10	2019	CONCLUSIONS: The combination of hydroxytyrosol, omega-3 fatty acids, and curcumin reduced inflammation as indicated by a reduction in CRP and reduced pain in patients with aromatase-induced musculoskeletal symptoms.	Curcumin	73-81	C-reactive protein	Homo sapiens	134-137
30694418-9	2019	Here, we demonstrate for the first time that oxidative stress could affect the amyloid-beta phagocytic potential of macrophages and hence by alleviating oxidative stress using curcumin, an anti-oxidant could enhance the amyloid-beta phagocytic efficacy of macrophages of patients with AD and MCI, although the responsiveness to curcumin might depends on the presence or absence of APOEepsilon4 allele.	Curcumin	328-336	amyloid beta precursor protein	Homo sapiens	220-232
30293230-3	2019	We evaluated whether the olive-derived polyphenol hydroxytyrosol combined with omega-3 fatty acids and curcumin would reduce CRP and musculoskeletal symptoms in breast cancer patients receiving adjuvant hormonal therapies.	Curcumin	103-111	C-reactive protein	Homo sapiens	125-128
30816425-1	2019	The aim of the present study was to investigate the protective effects of curcumin and its effect on the methyl ethyl ketone/extracellular signal regulated kinase/cAMP-response element binding protein (MEK/ERK/CREB) pathway.	Curcumin	74-82	Eph receptor B1	Rattus norvegicus	206-209
30747999-2	2019	We studied effects of the mTOR inhibitor rapamycin and the anti-inflammatory compound curcumin-also reported to inhibit the mTOR pathway-on epileptogenesis and inflammation in an in vitro organotypic hippocampal-entorhinal cortex slice culture model.	Curcumin	86-94	mechanistic target of rapamycin kinase	Homo sapiens	124-128
30747999-9	2019	Real-time quantitative polymerase chain reaction results indicated a trend toward lower expression of inflammatory markers IL-1beta and IL-6 and transforming growth factor beta after 3 weeks of treatment with rapamycin and curcumin compared to vehicle.	Curcumin	223-231	interleukin 1 beta	Homo sapiens	123-131
30747999-9	2019	Real-time quantitative polymerase chain reaction results indicated a trend toward lower expression of inflammatory markers IL-1beta and IL-6 and transforming growth factor beta after 3 weeks of treatment with rapamycin and curcumin compared to vehicle.	Curcumin	223-231	interleukin 6	Homo sapiens	136-140
30816425-10	2019	Curcumin was demonstrated to improve nerve damage symptoms and infarct volume, reduce brain water content, relieve neuronal apoptosis and also increase the expression of p-MEK, p-ERK, p-CREB, Bcl-2 and reduce Bax levels in vivo and in vitro.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	192-197
30968152-13	2019	Treatment with curcumin also increased the expression of P4HB and PRDX4 in the tissue of the small intestine.	Curcumin	15-23	peroxiredoxin 4	Rattus norvegicus	66-71
30816425-10	2019	Curcumin was demonstrated to improve nerve damage symptoms and infarct volume, reduce brain water content, relieve neuronal apoptosis and also increase the expression of p-MEK, p-ERK, p-CREB, Bcl-2 and reduce Bax levels in vivo and in vitro.	Curcumin	0-8	Eph receptor B1	Rattus norvegicus	179-182
30968152-16	2019	Furthermore, curcumin abolished NF-kappaB signal transduction and protected the cells from CPT-11-induced apoptosis by upregulating the expression of molecular chaperones, such as GRP78, P4HB and PRDX4, and suppressing the levels of the apoptosis-related proteins, CHOP and cleaved caspase-3.	Curcumin	13-21	peroxiredoxin 4	Rattus norvegicus	196-201
30816425-11	2019	In conclusion curcumin can mitigate focal cerebral ischemia-reperfusion injuries and this effect may be carried out through the MEK/ERK/CREB pathway.	Curcumin	14-22	Eph receptor B1	Rattus norvegicus	132-135
30592318-0	2019	Curcumin ameliorates monosodium urate-induced gouty arthritis through Nod-like receptor 3 inflammasome mediation via inhibiting nuclear factor-kappa B signaling.	Curcumin	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	70-89
30592318-5	2019	Then supernatants of MSU crystals-stimulated cells were collected and subjected to enzyme-linked immunosorbent assay for checking the modulation of curcumin on interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha.	Curcumin	148-156	interleukin 1 alpha	Rattus norvegicus	160-182
30592318-5	2019	Then supernatants of MSU crystals-stimulated cells were collected and subjected to enzyme-linked immunosorbent assay for checking the modulation of curcumin on interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha.	Curcumin	148-156	tumor necrosis factor	Rattus norvegicus	187-220
30592318-6	2019	Meanwhile, cells were analyzed by using Western blot analysis and quantitative polymerase chain reaction (QPCR) to investigate the effects of curcumin on Nod-like receptor 3 (NLRP3) inflammasome/nuclear factor-kappa B (NF-kappaB) signaling.	Curcumin	142-150	NLR family, pyrin domain containing 3	Rattus norvegicus	154-173
30592318-6	2019	Meanwhile, cells were analyzed by using Western blot analysis and quantitative polymerase chain reaction (QPCR) to investigate the effects of curcumin on Nod-like receptor 3 (NLRP3) inflammasome/nuclear factor-kappa B (NF-kappaB) signaling.	Curcumin	142-150	NLR family, pyrin domain containing 3	Rattus norvegicus	175-180
30592318-8	2019	RESULTS: Curcumin could reduce MSU crystals-induced IL-1beta and TNF-alpha in vitro.	Curcumin	9-17	interleukin 1 alpha	Rattus norvegicus	52-60
30592318-8	2019	RESULTS: Curcumin could reduce MSU crystals-induced IL-1beta and TNF-alpha in vitro.	Curcumin	9-17	tumor necrosis factor	Rattus norvegicus	65-74
30592318-9	2019	Western blot analysis and QPCR results revealed that curcumin regulated the production of these cytokines by suppressing the expression of inflammasome key components, including NLRP3, caspase-1.	Curcumin	53-61	NLR family, pyrin domain containing 3	Rattus norvegicus	178-183
30592318-11	2019	Intraperitoneal administration of curcumin could ameliorate symptoms of MSU-induced gouty arthritis, including the joint circumference, infiltration of neutrophils in knee joints, and production of IL-1beta, TNF-alpha, and elastase.	Curcumin	34-42	interleukin 1 alpha	Rattus norvegicus	198-206
30592318-11	2019	Intraperitoneal administration of curcumin could ameliorate symptoms of MSU-induced gouty arthritis, including the joint circumference, infiltration of neutrophils in knee joints, and production of IL-1beta, TNF-alpha, and elastase.	Curcumin	34-42	tumor necrosis factor	Rattus norvegicus	208-217
30592318-12	2019	Western blot analysis revealed that the levels of NLRP3, procaspase-1, caspase-1, pro-IL-1beta, and IL-1beta were downregulated by curcumin in vivo.	Curcumin	131-139	NLR family, pyrin domain containing 3	Rattus norvegicus	50-55
30592318-12	2019	Western blot analysis revealed that the levels of NLRP3, procaspase-1, caspase-1, pro-IL-1beta, and IL-1beta were downregulated by curcumin in vivo.	Curcumin	131-139	interleukin 1 alpha	Rattus norvegicus	86-94
30592318-13	2019	CONCLUSIONS: These results indicated that curcumin could effectively ameliorate MSU crystal-induced gouty arthritis through NLRP3 inflammasome mediation via inhibiting NF-kappaB signaling both in vitro and in vivo, suggesting a promising active ingredient for the prevention and treatment of gouty arthritis.	Curcumin	42-50	NLR family, pyrin domain containing 3	Rattus norvegicus	124-129
30746607-0	2019	Curcumin Alleviates beta Amyloid-Induced Neurotoxicity in HT22 Cells via Upregulating SOD2.	Curcumin	0-8	superoxide dismutase 2, mitochondrial	Mus musculus	86-90
30801961-12	2019	Both SOD activity and the protein expression levels of SOD2 were higher in the RI + curcumin and RI + amifostine groups than in the RI group.	Curcumin	84-92	superoxide dismutase 2, mitochondrial	Mus musculus	55-59
30816509-4	2019	The uptake rates for curcumin in OATP1B1-, OATP1B3- and OATP2B1-transfected CHO cells were 2- to 3-fold higher than wild-type cells.	Curcumin	21-29	solute carrier organic anion transporter family member 1B3	Homo sapiens	43-50
30746607-2	2019	The aim of this study is to determine whether the type 2 superoxide dismutase (SOD2) mediates curcumin-induced protective effects in Abeta-treated neuronal cells.	Curcumin	94-102	superoxide dismutase 2, mitochondrial	Mus musculus	79-83
30746607-6	2019	Downregulating SOD2 by using small interfering RNA (siRNA), however, significantly abolished the curcumin-induced protective and anti-oxidative effects in HT22 cells (P &lt; 0.05); the scramble (SC)-siRNA did not cause marked effects on the curcumin-induced protective effects (P &gt; 0.05).	Curcumin	97-105	superoxide dismutase 2, mitochondrial	Mus musculus	15-19
30746607-6	2019	Downregulating SOD2 by using small interfering RNA (siRNA), however, significantly abolished the curcumin-induced protective and anti-oxidative effects in HT22 cells (P &lt; 0.05); the scramble (SC)-siRNA did not cause marked effects on the curcumin-induced protective effects (P &gt; 0.05).	Curcumin	241-249	superoxide dismutase 2, mitochondrial	Mus musculus	15-19
30925757-6	2019	Both curcumin and resveratrol down-regulated the level of Toll-like-receptor 4 mRNA and protein expression in the intestine to inhibit the release of critical inflammation molecules (interleukin-1beta, tumor necrosis factor-alpha), and increase the secretion of immunoglobulin.	Curcumin	5-13	interleukin 1 beta	Homo sapiens	183-229
30998155-0	2019	[Curcumin Increases the Chemosensitivity of Multiple Myeloma to Bortezomib by Inhibiting the Notch1 Signaling Pathway].	Curcumin	1-9	notch receptor 1	Homo sapiens	93-99
30998155-7	2019	CONCLUSION: Curcumin can increase chemosensitivity of myeloma cells to bortezomib, this effect may be related to the inhibition of Notch1.	Curcumin	12-20	notch receptor 1	Homo sapiens	131-137
30936718-10	2019	Curcumin dose-dependently inhibited the proliferation, migration, and invasion of MG-63 cells and induced arrest of the G0/G1 phase and apoptosis by inhibiting the p-JAK2/p-STAT3 pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	173-178
30936718-0	2019	Curcumin inhibits the proliferation and invasion of MG-63 cells through inactivation of the p-JAK2/p-STAT3 pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	101-106
30936718-12	2019	In vivo study suggested that curcumin suppressed tumor growth through JAK2/STAT3 signaling.	Curcumin	29-37	signal transducer and activator of transcription 3	Homo sapiens	75-80
30936718-1	2019	Purpose: The aims of this study were to determine the effect of curcumin on osteosarcoma (OS) cells due to inactivation of the p-JAK2/p-STAT3 pathway and evaluate the prognostic value of this pathway in OS.	Curcumin	64-72	signal transducer and activator of transcription 3	Homo sapiens	136-141
30668337-10	2019	In addition, the curcumin in the pDNA/PamChol-Cur complex inhibited the nuclear translocation of NF-kappaB, suggesting an anti-inflammatory effect of curcumin.	Curcumin	17-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-106
30668337-10	2019	In addition, the curcumin in the pDNA/PamChol-Cur complex inhibited the nuclear translocation of NF-kappaB, suggesting an anti-inflammatory effect of curcumin.	Curcumin	150-158	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-106
30936718-13	2019	Conclusion: Curcumin-mediated inhibition of the proliferation and migration of MG-63 cells was associated with inactivation of JAK/STAT signaling.	Curcumin	12-20	signal transducer and activator of transcription 3	Homo sapiens	131-135
30841550-5	2019	Notably, anti-inflammatory and antioxidant properties of curcumin might reduce the expression of tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) and restore the imbalance between reactive oxygen species (ROS) production and antioxidant activity.	Curcumin	57-65	tumor necrosis factor	Homo sapiens	126-135
30472378-0	2019	Curcumin modulates the angiogenic potential of human endothelial cells via FAK/P-38 MAPK signaling pathway.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	79-83
30472378-10	2019	The expression level of VEGF was increased in curcumin treated cells at first 24 h time period.	Curcumin	46-54	vascular endothelial growth factor A	Homo sapiens	24-28
30472378-11	2019	Based on data from the current experiment, the protein level of p-FAK/FAK ratio was increased coincided with a decrease in p-P38/P38 ratio treatment with curcumin (p &lt; 0.0001).	Curcumin	154-162	mitogen-activated protein kinase 14	Homo sapiens	125-128
30472378-11	2019	Based on data from the current experiment, the protein level of p-FAK/FAK ratio was increased coincided with a decrease in p-P38/P38 ratio treatment with curcumin (p &lt; 0.0001).	Curcumin	154-162	mitogen-activated protein kinase 14	Homo sapiens	129-132
30472378-12	2019	These data demonstrated that curcumin inhibited HUVECs angiogenesis potential by modulation of FAK/P-38 MAPK signaling pathway.	Curcumin	29-37	mitogen-activated protein kinase 14	Homo sapiens	99-103
30841550-5	2019	Notably, anti-inflammatory and antioxidant properties of curcumin might reduce the expression of tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) and restore the imbalance between reactive oxygen species (ROS) production and antioxidant activity.	Curcumin	57-65	tumor necrosis factor	Homo sapiens	97-124
30841433-0	2019	Curcumin suppresses wilms" tumor metastasis by inhibiting RECK methylation.	Curcumin	0-8	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	58-62
30668131-3	2019	The combined application of curcumin (CUR) and celecoxib (CXB) has been proven to exert a synergistic antitumor effect via inhibiting the activation of NF-kappaB and STAT3.	Curcumin	28-36	signal transducer and activator of transcription 3	Mus musculus	166-171
30984574-11	2019	Moreover, this nanoformulation of curcumin restored p-Akt/t-Akt decrement induced by 6-OHDA.	Curcumin	34-42	AKT serine/threonine kinase 1	Homo sapiens	54-57
30984574-11	2019	Moreover, this nanoformulation of curcumin restored p-Akt/t-Akt decrement induced by 6-OHDA.	Curcumin	34-42	AKT serine/threonine kinase 1	Homo sapiens	60-63
30626802-0	2019	Curcumin Down-Regulates Toll-Like Receptor-2 Gene Expression and Function in Human Cystic Fibrosis Bronchial Epithelial Cells.	Curcumin	0-8	toll like receptor 2	Homo sapiens	24-44
30626802-3	2019	Here, we showed that curcumin, a well known anti-inflammatory agent derived from the curry spice turmeric, inhibits TLR2 expression in CF bronchial epithelial cell line, CFBE41o- cells.	Curcumin	21-29	toll like receptor 2	Homo sapiens	116-120
30626802-4	2019	Strong suppression of TLR2 gene and protein expression was observed at more than 40 microM of curcumin treatment in CFBE41o- cells.	Curcumin	94-102	toll like receptor 2	Homo sapiens	22-26
30626802-5	2019	Consistent with decreased expression of TLR2, PGN-dependent interleukin-8 (IL-8) gene up-regulation was markedly reduced by 40 microM of curcumin treatment.	Curcumin	137-145	toll like receptor 2	Homo sapiens	40-44
30626802-5	2019	Consistent with decreased expression of TLR2, PGN-dependent interleukin-8 (IL-8) gene up-regulation was markedly reduced by 40 microM of curcumin treatment.	Curcumin	137-145	C-X-C motif chemokine ligand 8	Homo sapiens	60-73
30626802-5	2019	Consistent with decreased expression of TLR2, PGN-dependent interleukin-8 (IL-8) gene up-regulation was markedly reduced by 40 microM of curcumin treatment.	Curcumin	137-145	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
30626802-7	2019	Interestingly, curcumin treatment decreased nuclear expression of transcription factor specificity protein 1 (SP1), a factor that is critical for increased basal TLR2 expression in CF cell line and primary cells.	Curcumin	15-23	Sp1 transcription factor	Homo sapiens	87-108
30841433-7	2019	After curcumin treatment, the level of RECK methylation was decreased significantly.	Curcumin	6-14	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	39-43
30626802-7	2019	Interestingly, curcumin treatment decreased nuclear expression of transcription factor specificity protein 1 (SP1), a factor that is critical for increased basal TLR2 expression in CF cell line and primary cells.	Curcumin	15-23	toll like receptor 2	Homo sapiens	162-166
30841433-13	2019	Moreover, curcumin could inhibit RECK methylation, thereby abates the expression of MMPs, and suppresses the tumor progression and metastasis of WT.	Curcumin	10-18	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	33-37
30626802-9	2019	Taken together, our study shows that curcumin down-regulates TLR2 gene expression and function in CF bronchial epithelial cells possibly by accelerating SP1 degradation via an oxidative process.	Curcumin	37-45	toll like receptor 2	Homo sapiens	61-65
30572745-4	2019	Moreover, curcumin polymeric micelles conjugated with FLT3-specific peptide (FLT3-Cur-micelles) were prepared using a film hydration method to increase curcumin solubility and the inhibitory effect on MV4-11 cells was evaluated.	Curcumin	152-160	fms related receptor tyrosine kinase 3	Homo sapiens	77-81
30572745-0	2019	FLT3-specific curcumin micelles enhance activity of curcumin on FLT3-ITD overexpressing MV4-11 leukemic cells.	Curcumin	14-22	fms related receptor tyrosine kinase 3	Homo sapiens	0-4
30442066-9	2019	The in vivo studies in rat ear model displayed a ~2 fold reduction in comedones count and cytokines (TNF-alpha and IL-1beta) on co-application with curcumin and lauric acid liposomal gel compared to placebo treated group.	Curcumin	148-156	tumor necrosis factor	Rattus norvegicus	101-110
30442066-9	2019	The in vivo studies in rat ear model displayed a ~2 fold reduction in comedones count and cytokines (TNF-alpha and IL-1beta) on co-application with curcumin and lauric acid liposomal gel compared to placebo treated group.	Curcumin	148-156	interleukin 1 beta	Rattus norvegicus	115-123
30572745-0	2019	FLT3-specific curcumin micelles enhance activity of curcumin on FLT3-ITD overexpressing MV4-11 leukemic cells.	Curcumin	14-22	fms related receptor tyrosine kinase 3	Homo sapiens	64-68
30572745-9	2019	In addition, FLT3-Cur-micelles demonstrated excellent internalization and increased curcumin accumulation in leukemic cells when compared to free curcumin.	Curcumin	84-92	fms related receptor tyrosine kinase 3	Homo sapiens	13-17
30572745-0	2019	FLT3-specific curcumin micelles enhance activity of curcumin on FLT3-ITD overexpressing MV4-11 leukemic cells.	Curcumin	52-60	fms related receptor tyrosine kinase 3	Homo sapiens	0-4
30572745-0	2019	FLT3-specific curcumin micelles enhance activity of curcumin on FLT3-ITD overexpressing MV4-11 leukemic cells.	Curcumin	52-60	fms related receptor tyrosine kinase 3	Homo sapiens	64-68
30572745-9	2019	In addition, FLT3-Cur-micelles demonstrated excellent internalization and increased curcumin accumulation in leukemic cells when compared to free curcumin.	Curcumin	146-154	fms related receptor tyrosine kinase 3	Homo sapiens	13-17
30572745-3	2019	In this study, the cytotoxicity and inhibitory effect of curcumin on cell cycle of FLT3-ITD overexpressing MV4-11 leukemic cells were evaluated.	Curcumin	57-65	fms related receptor tyrosine kinase 3	Homo sapiens	83-87
30572745-4	2019	Moreover, curcumin polymeric micelles conjugated with FLT3-specific peptide (FLT3-Cur-micelles) were prepared using a film hydration method to increase curcumin solubility and the inhibitory effect on MV4-11 cells was evaluated.	Curcumin	10-18	fms related receptor tyrosine kinase 3	Homo sapiens	54-58
30572745-12	2019	In summary, FLT3-Cur-micelles are a promising nanocarrier system for enhancing anti-leukemic activity of curcumin and suitable for further preclinical studies.	Curcumin	105-113	fms related receptor tyrosine kinase 3	Homo sapiens	12-16
30572745-4	2019	Moreover, curcumin polymeric micelles conjugated with FLT3-specific peptide (FLT3-Cur-micelles) were prepared using a film hydration method to increase curcumin solubility and the inhibitory effect on MV4-11 cells was evaluated.	Curcumin	10-18	fms related receptor tyrosine kinase 3	Homo sapiens	77-81
30572745-4	2019	Moreover, curcumin polymeric micelles conjugated with FLT3-specific peptide (FLT3-Cur-micelles) were prepared using a film hydration method to increase curcumin solubility and the inhibitory effect on MV4-11 cells was evaluated.	Curcumin	152-160	fms related receptor tyrosine kinase 3	Homo sapiens	54-58
30727807-0	2019	Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	35-38
30825198-0	2019	Activation of PERK in ET-1- and thrombin-induced pulmonary fibroblast differentiation: Inhibitory effects of curcumin.	Curcumin	109-117	endothelin 1	Homo sapiens	22-26
30825198-0	2019	Activation of PERK in ET-1- and thrombin-induced pulmonary fibroblast differentiation: Inhibitory effects of curcumin.	Curcumin	109-117	coagulation factor II, thrombin	Homo sapiens	32-40
30727807-9	2019	A high dose of curcumin strongly inhibited p-Akt protein expression.	Curcumin	15-23	AKT serine/threonine kinase 1	Homo sapiens	45-48
30727807-11	2019	These results suggest that curcumin negatively modulated the miR-21/PTEN/Akt pathway.	Curcumin	27-35	AKT serine/threonine kinase 1	Homo sapiens	73-76
30727807-13	2019	Additionally, the inhibitory effects of curcumin on the miR-21/PTEN/Akt pathway were significantly enhanced.	Curcumin	40-48	AKT serine/threonine kinase 1	Homo sapiens	68-71
30668434-11	2019	Furthermore, PTX plus curcumin most impressively activated caspase-3, effector of apoptosis pathways, and reduced the expression of the anti-apoptotic protein Bcl-2.	Curcumin	22-30	BCL2, apoptosis regulator	Rattus norvegicus	159-164
30806584-0	2019	Synergistically enhanced anticancer effect of codelivered curcumin and siPlk1 by stimuli-responsive alpha-lactalbumin nanospheres.	Curcumin	58-66	lactalbumin alpha	Homo sapiens	100-117
30806584-1	2019	AIM: To achieve enhanced anticancer efficacy by combined siPlk1 and curcumin (cur) therapy using alpha-lactalbumin (alpha-lac) nanocarrier delivery.	Curcumin	68-76	lactalbumin alpha	Homo sapiens	97-114
30899155-0	2019	Molecular designing, virtual screening and docking study of novel curcumin analogue as mutation (S769L and K846R) selective inhibitor for EGFR.	Curcumin	66-74	epidermal growth factor receptor	Homo sapiens	138-142
30863383-7	2019	We show that both anacardic acid and curcumin inhibit GAPDH from two bacterial pathogens through uncompetitive and non-competitive mechanisms, suggesting GAPDH as a relevant pharmaceutical target for antibacterial development.	Curcumin	37-45	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	54-59
30863383-7	2019	We show that both anacardic acid and curcumin inhibit GAPDH from two bacterial pathogens through uncompetitive and non-competitive mechanisms, suggesting GAPDH as a relevant pharmaceutical target for antibacterial development.	Curcumin	37-45	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	154-159
30838091-11	2019	The cell survival protein Akt1 was downregulated by curcumin with and without the nanostructure.	Curcumin	52-60	AKT serine/threonine kinase 1	Homo sapiens	26-30
30838091-13	2019	But other ER resident protein like IRE1alpha, PERK and GRP78 were downregulated indicating curcumin disturbs ER homeostasis.	Curcumin	91-99	heat shock protein family A (Hsp70) member 5	Homo sapiens	55-60
30611528-7	2019	The results showed that curcumin can suppresses adipocyte differentiation in a dose-dependent manner and inhibited the expression of PPARgamma, C/EBPalpha, and FABP4.	Curcumin	24-32	peroxisome proliferator activated receptor gamma	Homo sapiens	133-142
30312017-0	2019	Curcumin Ameliorates Memory Deficits by Enhancing Lactate Content and MCT2 Expression in APP/PS1 Transgenic Mouse Model of Alzheimer"s Disease.	Curcumin	0-8	solute carrier family 16 (monocarboxylic acid transporters), member 7	Mus musculus	70-74
30312017-8	2019	Brain lactate content and MCT2 protein level were increased in curcumin-treated APP/PS1 mice than in APP/PS1 mice.	Curcumin	63-71	solute carrier family 16 (monocarboxylic acid transporters), member 7	Mus musculus	26-30
30611528-7	2019	The results showed that curcumin can suppresses adipocyte differentiation in a dose-dependent manner and inhibited the expression of PPARgamma, C/EBPalpha, and FABP4.	Curcumin	24-32	CCAAT enhancer binding protein alpha	Homo sapiens	144-154
30611528-8	2019	Importantly, curcumin can also suppress the expression of Kruppel-like factor 15, which may bind to the PPARgamma promoter, resulting in downregulation of PPARgamma expression to inhibit the adipogenic differentiation of hMSCs.	Curcumin	13-21	peroxisome proliferator activated receptor gamma	Homo sapiens	104-113
30611528-8	2019	Importantly, curcumin can also suppress the expression of Kruppel-like factor 15, which may bind to the PPARgamma promoter, resulting in downregulation of PPARgamma expression to inhibit the adipogenic differentiation of hMSCs.	Curcumin	13-21	peroxisome proliferator activated receptor gamma	Homo sapiens	155-164
30840308-0	2019	Curcumin inhibits hypoxia inducible factor-1alpha-induced inflammation and apoptosis in macrophages through an ERK dependent pathway.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-49
29945277-10	2019	In addition, curcumin downregulated Ctr1 and OCT2 drug transporters as compared to cisplatin group.	Curcumin	13-21	POU class 2 homeobox 2	Rattus norvegicus	45-49
30840308-0	2019	Curcumin inhibits hypoxia inducible factor-1alpha-induced inflammation and apoptosis in macrophages through an ERK dependent pathway.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	111-114
30840308-2	2019	Hypoxia has been proven to participate in the progression of atherosclerosis, while curcumin can inhibit hypoxia-inducible factor 1alpha (HIF-1alpha).	Curcumin	84-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-136
30840308-2	2019	Hypoxia has been proven to participate in the progression of atherosclerosis, while curcumin can inhibit hypoxia-inducible factor 1alpha (HIF-1alpha).	Curcumin	84-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-148
30840308-5	2019	Western blot was applied to examine the changes of HIF-1alpha, ERK and p-ERK after treatment with curcumin.	Curcumin	98-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
30840308-5	2019	Western blot was applied to examine the changes of HIF-1alpha, ERK and p-ERK after treatment with curcumin.	Curcumin	98-106	mitogen-activated protein kinase 1	Homo sapiens	63-66
30840308-5	2019	Western blot was applied to examine the changes of HIF-1alpha, ERK and p-ERK after treatment with curcumin.	Curcumin	98-106	mitogen-activated protein kinase 1	Homo sapiens	73-76
30840308-9	2019	RESULTS: Here, we found curcumin inhibited the expression of HIF-1alpha at the protein level in macrophages under hypoxic condition and curcumin and HIF-1alpha inhibitors repressed the total cholesterol and lipid level in macrophage under hypoxic condition.	Curcumin	24-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-71
30840308-9	2019	RESULTS: Here, we found curcumin inhibited the expression of HIF-1alpha at the protein level in macrophages under hypoxic condition and curcumin and HIF-1alpha inhibitors repressed the total cholesterol and lipid level in macrophage under hypoxic condition.	Curcumin	136-144	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-71
30840308-10	2019	Moreover, curcumin also decreased the expression of HIF-1alpha downstream genes, VEGF, HMOX1, ROS and PDGF.	Curcumin	10-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62
30840308-10	2019	Moreover, curcumin also decreased the expression of HIF-1alpha downstream genes, VEGF, HMOX1, ROS and PDGF.	Curcumin	10-18	vascular endothelial growth factor A	Homo sapiens	81-85
30840308-11	2019	Then, the data show the HIF-1alpha-induced apoptosis and inflammation of macrophages were inhibited by curcumin.	Curcumin	103-111	hypoxia inducible factor 1 subunit alpha	Homo sapiens	24-34
30840308-14	2019	CONCLUSIONS: We describe that curcumin inhibited the HIF-1alpha-induced apoptosis and inflammation of macrophages via ERK signaling pathways.	Curcumin	30-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-63
30840308-14	2019	CONCLUSIONS: We describe that curcumin inhibited the HIF-1alpha-induced apoptosis and inflammation of macrophages via ERK signaling pathways.	Curcumin	30-38	mitogen-activated protein kinase 1	Homo sapiens	118-121
30551030-0	2019	Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress.	Curcumin	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	66-71
30551030-6	2019	Additionally, the curcumin could effectively decrease mRNA expression of proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and suppress NF-kappaB activation.	Curcumin	18-26	interleukin 1 beta	Rattus norvegicus	100-108
30551030-6	2019	Additionally, the curcumin could effectively decrease mRNA expression of proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and suppress NF-kappaB activation.	Curcumin	18-26	interleukin 6	Rattus norvegicus	110-114
30551030-6	2019	Additionally, the curcumin could effectively decrease mRNA expression of proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and suppress NF-kappaB activation.	Curcumin	18-26	tumor necrosis factor	Rattus norvegicus	120-129
30551030-7	2019	Curcumin also inhibited the stressed-induced P2X7R/NLRP3 inflammasome axis activation, along with the reduced transformation of pro-IL-1beta to mature IL-1beta.	Curcumin	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	51-56
30551030-7	2019	Curcumin also inhibited the stressed-induced P2X7R/NLRP3 inflammasome axis activation, along with the reduced transformation of pro-IL-1beta to mature IL-1beta.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	132-140
30551030-7	2019	Curcumin also inhibited the stressed-induced P2X7R/NLRP3 inflammasome axis activation, along with the reduced transformation of pro-IL-1beta to mature IL-1beta.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	151-159
30551030-9	2019	In conclusion, the study revealed that curcumin relieves a depressive-like state through the inhibition of the NLRP3 inflammasome and kynurenine pathway.	Curcumin	39-47	NLR family, pyrin domain containing 3	Rattus norvegicus	111-116
30462567-0	2019	Curcumin improves exercise performance of mice with coronary artery ligation-induced HFrEF: Nrf2 and antioxidant mechanisms in skeletal muscle.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-96
30462567-3	2019	We further hypothesized that curcumin, a Nrf2 activator, would preserve or increase exercise capacity in HF.	Curcumin	29-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	41-45
30541364-0	2019	A novel curcumin-loaded nanoparticle restricts atherosclerosis development and promotes plaques stability in apolipoprotein E deficient mice.	Curcumin	8-16	apolipoprotein E	Mus musculus	109-125
30462567-12	2019	Curcumin prevents the decline in running performance in HFrEF mice by upregulating antioxidant defenses in skeletal muscle, likely mediated by activating Nrf2 signaling.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	154-158
30346064-4	2019	In short-term experiments, the combination of UA + Curc given topically prior to 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited activation of epidermal EGFR, p70S6K, NF-kappaB p50, Src, c-Jun, Rb, and IkappaBalpha.	Curcumin	51-55	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	196-199
29310523-3	2019	Till now only two scaffolds (triazinone and curcumin) derivatives have been reported as BACE-1 and GSK-3beta dual inhibitors.	Curcumin	44-52	beta-secretase 1	Homo sapiens	88-94
30346064-4	2019	In short-term experiments, the combination of UA + Curc given topically prior to 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited activation of epidermal EGFR, p70S6K, NF-kappaB p50, Src, c-Jun, Rb, and IkappaBalpha.	Curcumin	51-55	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	221-233
30529561-0	2019	A dual fluorescent reverse targeting drug delivery system based on curcumin-loaded ovalbumin nanoparticles for allergy treatment.	Curcumin	67-75	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	83-92
30467667-9	2019	Overexpression of GH triggered resistant profile against curcumin (20 microM) treatment for 24 h, but this resistance was accomplished following 48 h curcumin exposure.	Curcumin	57-65	growth hormone 1	Homo sapiens	18-20
30467667-9	2019	Overexpression of GH triggered resistant profile against curcumin (20 microM) treatment for 24 h, but this resistance was accomplished following 48 h curcumin exposure.	Curcumin	150-158	growth hormone 1	Homo sapiens	18-20
30467667-10	2019	Concomitantly, forced GH induced invasion and metastasis through EMT and NF-kappaB activation were prevented by long-term curcumin exposure in T47D cells.	Curcumin	122-130	growth hormone 1	Homo sapiens	22-24
30467667-11	2019	Moreover, 48 h curcumin treatment prevented the autocrine GH-mediated miR-182-96-183 cluster expression stimulation in T47D cells.	Curcumin	15-23	growth hormone 1	Homo sapiens	58-60
30467667-12	2019	In consequence, curcumin treatment for 48 h, prevented autocrine GH-triggered invasion-metastasis, EMT activation through inhibiting NF-kappaB signaling and miR-182-96-183 cluster expression and induced apoptotic cell death by modulating Bcl-2 family members in T47D breast cancer cells.	Curcumin	16-24	growth hormone 1	Homo sapiens	65-67
30467667-12	2019	In consequence, curcumin treatment for 48 h, prevented autocrine GH-triggered invasion-metastasis, EMT activation through inhibiting NF-kappaB signaling and miR-182-96-183 cluster expression and induced apoptotic cell death by modulating Bcl-2 family members in T47D breast cancer cells.	Curcumin	16-24	BCL2 apoptosis regulator	Homo sapiens	238-243
30467667-0	2019	Curcumin prevented human autocrine growth hormone (GH) signaling mediated NF-kappaB activation and miR-183-96-182 cluster stimulated epithelial mesenchymal transition in T47D breast cancer cells.	Curcumin	0-8	growth hormone 1	Homo sapiens	35-49
30467667-0	2019	Curcumin prevented human autocrine growth hormone (GH) signaling mediated NF-kappaB activation and miR-183-96-182 cluster stimulated epithelial mesenchymal transition in T47D breast cancer cells.	Curcumin	0-8	growth hormone 1	Homo sapiens	51-53
30467667-2	2019	Curcumin (diferuloylmethane), a polyphenol derived from turmeric (Curcuma longa), has anti-proliferative, anti-carcinogenic, anti-hormonal effect via acting on PI3K/Akt, NF-kappaB and JAK/STAT signaling.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	165-168
30467667-2	2019	Curcumin (diferuloylmethane), a polyphenol derived from turmeric (Curcuma longa), has anti-proliferative, anti-carcinogenic, anti-hormonal effect via acting on PI3K/Akt, NF-kappaB and JAK/STAT signaling.	Curcumin	10-27	AKT serine/threonine kinase 1	Homo sapiens	165-168
30467667-4	2019	This study aimed to investigate the role of NF-kappaB signaling and miR-182-96-183 cluster expression profile on autocrine GH-mediated curcumin resistance, which was prevented by time-dependent curcumin treatment in T47D breast cancer cells.	Curcumin	135-143	growth hormone 1	Homo sapiens	123-125
30467667-4	2019	This study aimed to investigate the role of NF-kappaB signaling and miR-182-96-183 cluster expression profile on autocrine GH-mediated curcumin resistance, which was prevented by time-dependent curcumin treatment in T47D breast cancer cells.	Curcumin	194-202	growth hormone 1	Homo sapiens	123-125
30467667-5	2019	Dose- and time-dependent effect of curcumin on T47D wt and GH+ breast cancer cells were evaluated by MTT cell viability and trypan blue assay.	Curcumin	35-43	growth hormone 1	Homo sapiens	59-61
30467667-7	2019	Immunoblotting performed to investigate the effect of curcumin on PI3K/Akt/MAPK, NF-kappaB signaling.	Curcumin	54-62	AKT serine/threonine kinase 1	Homo sapiens	71-74
30569107-0	2019	Curcumin inhibits high glucose-induced inflammatory injury in human retinal pigment epithelial cells through the ROS-PI3K/AKT/mTOR signaling pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	122-125
30569107-0	2019	Curcumin inhibits high glucose-induced inflammatory injury in human retinal pigment epithelial cells through the ROS-PI3K/AKT/mTOR signaling pathway.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	126-130
30529561-2	2019	In this study, a dual fluorescent reverse targeting drug delivery system based on curcumin-loaded ovalbumin nanoparticles is developed for allergy treatment.	Curcumin	82-90	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	98-107
30529561-3	2019	The self-crosslinked ovalbumin nanoparticles achieved the double function of reverse targeting and sustained delivery carriers to maximize the anti-allergy of curcumin.	Curcumin	159-167	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	21-30
30529561-5	2019	The curcumin-loaded ovalbumin nanoparticles exert stronger and more effective treatment on the immunomodulatory role.	Curcumin	4-12	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	20-29
31250606-24	2019	CONCLUSION: Curcumin and J7 could inhibit the oxidative stress damage of testicular tissue in diabetic rats, which might be related with the activation of the Nrf2-ARE signaling pathway.	Curcumin	12-20	NFE2 like bZIP transcription factor 2	Rattus norvegicus	159-163
30402990-9	2019	Overall, this meta-analysis suggests that taking curcumin-containing supplements may exert anti-inflammatory and antioxidant properties through a significant reduction in IL-6, hs-CRP, and MDA levels.	Curcumin	49-57	interleukin 6	Homo sapiens	171-175
30560591-0	2019	Curcumin Inhibits Proliferation of Synovial Cells by Downregulating Expression of Matrix Metalloproteinase-3 in Osteoarthritis.	Curcumin	0-8	matrix metallopeptidase 3	Homo sapiens	82-108
30560591-11	2019	Western blot results further showed that the expression of MMP3 was 44% lower in the untreated groups compared with the curcumin group, and the expressions of FN1 and collagen III were increased by 112% and 84%, respectively, which indicated that curcumin inhibited MMP3 expression and decreased osteoarthritis synovial cell activity.	Curcumin	120-128	matrix metallopeptidase 3	Homo sapiens	59-63
30560591-11	2019	Western blot results further showed that the expression of MMP3 was 44% lower in the untreated groups compared with the curcumin group, and the expressions of FN1 and collagen III were increased by 112% and 84%, respectively, which indicated that curcumin inhibited MMP3 expression and decreased osteoarthritis synovial cell activity.	Curcumin	120-128	fibronectin 1	Homo sapiens	159-162
30560591-11	2019	Western blot results further showed that the expression of MMP3 was 44% lower in the untreated groups compared with the curcumin group, and the expressions of FN1 and collagen III were increased by 112% and 84%, respectively, which indicated that curcumin inhibited MMP3 expression and decreased osteoarthritis synovial cell activity.	Curcumin	247-255	matrix metallopeptidase 3	Homo sapiens	59-63
30560591-11	2019	Western blot results further showed that the expression of MMP3 was 44% lower in the untreated groups compared with the curcumin group, and the expressions of FN1 and collagen III were increased by 112% and 84%, respectively, which indicated that curcumin inhibited MMP3 expression and decreased osteoarthritis synovial cell activity.	Curcumin	247-255	fibronectin 1	Homo sapiens	159-162
30560591-11	2019	Western blot results further showed that the expression of MMP3 was 44% lower in the untreated groups compared with the curcumin group, and the expressions of FN1 and collagen III were increased by 112% and 84%, respectively, which indicated that curcumin inhibited MMP3 expression and decreased osteoarthritis synovial cell activity.	Curcumin	247-255	matrix metallopeptidase 3	Homo sapiens	266-270
30560591-15	2019	Curcumin could reduce cell viability, inhibit cell proliferation, increase cell apoptosis, and eventually alleviate inflammation of osteoarthritis by inhibiting the expression of MMP3.	Curcumin	0-8	matrix metallopeptidase 3	Homo sapiens	179-183
30827313-0	2019	[Effect of curcumin on expressions of CD11b and CD19 in peripheral blood of heat stroke rats in a simulation dry-heat environment].	Curcumin	11-19	integrin subunit alpha M	Rattus norvegicus	38-43
30827313-0	2019	[Effect of curcumin on expressions of CD11b and CD19 in peripheral blood of heat stroke rats in a simulation dry-heat environment].	Curcumin	11-19	CD19 molecule	Rattus norvegicus	48-52
30827313-1	2019	OBJECTIVE: To investigate the effects of different doses of curcumin on the levels of immune factors CD11b and CD19 in peripheral blood of heat stroke rats in a simulation dry-heat environment.	Curcumin	60-68	integrin subunit alpha M	Rattus norvegicus	101-106
30827313-1	2019	OBJECTIVE: To investigate the effects of different doses of curcumin on the levels of immune factors CD11b and CD19 in peripheral blood of heat stroke rats in a simulation dry-heat environment.	Curcumin	60-68	CD19 molecule	Rattus norvegicus	111-115
30827313-6	2019	RESULTS: With the extension of time in the simulated dry and heat environment, the level of CD11b in peripheral blood was gradually increased in each group, and the peak value was reached at 150 minutes, the NS control group, solvent control group and curcumin low, medium and high dose pretreatment groups were 0.346+-0.013, 0.342+-0.013, 0.342+-0.012, 0.325+-0.012, and 0.281+-0.012, respectively.	Curcumin	252-260	integrin subunit alpha M	Rattus norvegicus	92-97
30827313-11	2019	CONCLUSIONS: Curcumin pretreatment can reduce the level of CD11b and increase the level of CD19 in peripheral blood of rats with dry heat stroke in the early and middle stages, which may enhance the heat resistance and prevent the occurrence of multiple organ dysfunction by increasing the body immunity, and this effect has nothing to do with the dose of curcumin.	Curcumin	13-21	integrin subunit alpha M	Rattus norvegicus	59-64
30827313-11	2019	CONCLUSIONS: Curcumin pretreatment can reduce the level of CD11b and increase the level of CD19 in peripheral blood of rats with dry heat stroke in the early and middle stages, which may enhance the heat resistance and prevent the occurrence of multiple organ dysfunction by increasing the body immunity, and this effect has nothing to do with the dose of curcumin.	Curcumin	13-21	CD19 molecule	Rattus norvegicus	91-95
30684965-0	2019	Curcumin and/or omega-3 polyunsaturated fatty acids supplementation reduces insulin resistance and blood lipids in individuals with high risk of type 2 diabetes: a randomised controlled trial.	Curcumin	0-8	insulin	Homo sapiens	76-83
30684965-12	2019	CONCLUSION: Reduction in insulin resistance and triglycerides by curcumin and LCn-3PUFA appears to be attractive strategies for lowering the risk of developing T2D.	Curcumin	65-73	insulin	Homo sapiens	25-32
30679571-8	2019	Curcumin triggered the expression of nuclear peroxisome proliferator-activated receptor gamma (PPARgamma).	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	45-93
30679571-8	2019	Curcumin triggered the expression of nuclear peroxisome proliferator-activated receptor gamma (PPARgamma).	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	95-104
30679571-0	2019	Curcumin inhibits the TGF-beta1-dependent differentiation of lung fibroblasts via PPARgamma-driven upregulation of cathepsins B and L.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	22-31
30679571-0	2019	Curcumin inhibits the TGF-beta1-dependent differentiation of lung fibroblasts via PPARgamma-driven upregulation of cathepsins B and L.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	82-91
30679571-3	2019	Here we established that curcumin, a potent antifibrotic drug used in traditional Asian medicine, impaired the expression of both alpha-smooth muscle actin and mature TGF-beta1 and inhibited the differentiation of human lung fibroblasts (CCD-19Lu cells).	Curcumin	25-33	transforming growth factor beta 1	Homo sapiens	167-176
30679571-4	2019	Curcumin induced a compelling upregulation of CatB and CatL.	Curcumin	0-8	cathepsin L	Homo sapiens	55-59
30679571-9	2019	Contrariwise PPARgamma inhibition, either by an antagonist (2-chloro-5-nitro-N-4-pyridinyl-benzamide) or by RNA silencing, restored TGF-beta1-driven differentiation of curcumin-treated CCD-19Lu cells.	Curcumin	168-176	peroxisome proliferator activated receptor gamma	Homo sapiens	13-22
30679571-9	2019	Contrariwise PPARgamma inhibition, either by an antagonist (2-chloro-5-nitro-N-4-pyridinyl-benzamide) or by RNA silencing, restored TGF-beta1-driven differentiation of curcumin-treated CCD-19Lu cells.	Curcumin	168-176	transforming growth factor beta 1	Homo sapiens	132-141
30551471-0	2019	Curcumin augments the cardioprotective effect of metformin in an experimental model of type I diabetes mellitus; Impact of Nrf2/HO-1 and JAK/STAT pathways.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	123-127
30774454-4	2019	Results: In cell culture, both CMC 2.24 and curcumin appeared similarly effective in suppressing LPS-induced cytokine (IL-1beta and TNF-alpha) secretion by mononuclear inflammatory cells; however, CMC 2.24 significantly reduced MMP-9 secretion by 78% (P&lt;0.05) whereas curcumin was ineffective.	Curcumin	44-52	interleukin 1 beta	Rattus norvegicus	119-127
30774454-4	2019	Results: In cell culture, both CMC 2.24 and curcumin appeared similarly effective in suppressing LPS-induced cytokine (IL-1beta and TNF-alpha) secretion by mononuclear inflammatory cells; however, CMC 2.24 significantly reduced MMP-9 secretion by 78% (P&lt;0.05) whereas curcumin was ineffective.	Curcumin	44-52	tumor necrosis factor	Rattus norvegicus	132-141
30666189-0	2018	Neuroprotective Effects of Curcumin on IL-1beta-Induced Neuronal Apoptosis and Depression-Like Behaviors Caused by Chronic Stress in Rats.	Curcumin	27-35	interleukin 1 beta	Rattus norvegicus	39-47
30666189-5	2018	Our results show that chronic administration of curcumin (40 mg/kg, i.p., 5 weeks) prior to stress exposure significantly alleviated depression-like behaviors, expression of the proinflammatory cytokine interleukin-1beta (IL-1beta) and inhibited neuronal apoptosis within neurons of the ventromedial prefrontal cortex (vmPFC).	Curcumin	48-56	interleukin 1 beta	Rattus norvegicus	203-220
30666189-5	2018	Our results show that chronic administration of curcumin (40 mg/kg, i.p., 5 weeks) prior to stress exposure significantly alleviated depression-like behaviors, expression of the proinflammatory cytokine interleukin-1beta (IL-1beta) and inhibited neuronal apoptosis within neurons of the ventromedial prefrontal cortex (vmPFC).	Curcumin	48-56	interleukin 1 beta	Rattus norvegicus	222-230
30666189-7	2018	More important, within the vmPFC of wild type rats, overexpression of IL-1beta via intracerebral infusion of AAV-IL-1beta induced p38 MAPK phosphorylation and neuronal apoptosis, which could be significantly prevented by chronic treatment of curcumin.	Curcumin	242-250	interleukin 1 beta	Rattus norvegicus	70-78
30666189-7	2018	More important, within the vmPFC of wild type rats, overexpression of IL-1beta via intracerebral infusion of AAV-IL-1beta induced p38 MAPK phosphorylation and neuronal apoptosis, which could be significantly prevented by chronic treatment of curcumin.	Curcumin	242-250	interleukin 1 beta	Rattus norvegicus	113-121
30666189-8	2018	Collectively, these findings reveal that curcumin protects against IL-1beta-induced neuronal apoptosis, which may be related to the display of depression-like behaviors in stressed rats.	Curcumin	41-49	interleukin 1 beta	Rattus norvegicus	67-75
30800669-7	2019	Importantly, curcumin activated neurogenesis of NTERA2 cells via the activation of autophagy, since autophagy-related genes, such as LC3, LAMP1, and ATG5, were upregulated along with the expression of neural genes.	Curcumin	13-21	autophagy related 5	Homo sapiens	149-153
30800209-4	2019	Curcumin could significantly suppress the above HSC-induced effects in HCC and could abrogate ROS and HIF-1alpha expression in HCC.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-112
30800209-5	2019	HIF-1alpha or connective tissue growth factor (CTGF) knockdown could abolish the aforementioned curcumin affection.	Curcumin	96-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
30800209-7	2019	In addition, nuclear factor E2-related factor 2 (Nrf2) and glutathione (GSH) are involved in curcumin protection of HCC.	Curcumin	93-101	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
30800209-8	2019	These data indicate that curcumin may induce ROS scavenging by upregulating Nrf2 and GSH, thus inhibiting HIF-1alpha stabilization to suppress CTGF expression to exhibit its protection on HCC.	Curcumin	25-33	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
30800209-8	2019	These data indicate that curcumin may induce ROS scavenging by upregulating Nrf2 and GSH, thus inhibiting HIF-1alpha stabilization to suppress CTGF expression to exhibit its protection on HCC.	Curcumin	25-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
30788007-0	2019	Therapeutic ultrasound potentiates the anti-nociceptive and anti-inflammatory effects of curcumin to postoperative pain via Sirt1/NF-kappaB signaling pathway [Retraction].	Curcumin	89-97	nuclear factor kappa B subunit 1	Homo sapiens	130-139
30342014-0	2019	The soluble curcumin derivative NDS27 inhibits superoxide anion production by neutrophils and acts as substrate and reversible inhibitor of myeloperoxidase.	Curcumin	12-20	myeloperoxidase	Homo sapiens	140-155
30342014-1	2019	A water-soluble curcumin lysinate incorporated into hydroxypropyl-beta-cyclodextrin (NDS27) has been developed and shown anti-inflammatory properties but no comparative study has been made in parallel with its parent molecule, curcumin on polymorphonuclear neutrophils (PMNs) and myeloperoxidase (MPO) involved in inflammation.	Curcumin	16-24	myeloperoxidase	Homo sapiens	280-295
30342014-1	2019	A water-soluble curcumin lysinate incorporated into hydroxypropyl-beta-cyclodextrin (NDS27) has been developed and shown anti-inflammatory properties but no comparative study has been made in parallel with its parent molecule, curcumin on polymorphonuclear neutrophils (PMNs) and myeloperoxidase (MPO) involved in inflammation.	Curcumin	16-24	myeloperoxidase	Homo sapiens	297-300
30342014-3	2019	It was shown that curcumin and NDS27 exhibit similar inhibition activities on superoxide anion release by stimulated PMNs but also on MPO peroxidase and halogenation activities.	Curcumin	18-26	myeloperoxidase	Homo sapiens	134-137
30342014-4	2019	The action mechanism of curcumin and NDS27 on the MPO activity was refined by stopped-flow and docking analyses.	Curcumin	24-32	myeloperoxidase	Homo sapiens	50-53
30342014-5	2019	We demonstrate that both curcumin and NDS27 are reversible inhibitors of MPO by acting as excellent electron donors for redox intermediate Compound I (~107 M-1 s-1) but not for Compound II (~103 M-1 s-1) in the peroxidase cycle of the enzyme, thereby trapping the enzyme in the Compound II state.	Curcumin	25-33	myeloperoxidase	Homo sapiens	73-76
30342014-6	2019	Docking calculations show that curcumin is able to enter the enzymatic pocket of MPO and bind to the heme cavity by pi-stacking and formation of hydrogen bonds involving substituents from both aromatic rings.	Curcumin	31-39	myeloperoxidase	Homo sapiens	81-84
30342014-7	2019	Hydroxypropyl-beta-cyclodextrin is too bulky to enter MPO channel leading to the binding site suggesting a full release of curcumin from the cyclodextrin thereby allowing its full access to the active site of MPO.	Curcumin	123-131	myeloperoxidase	Homo sapiens	54-57
30342014-7	2019	Hydroxypropyl-beta-cyclodextrin is too bulky to enter MPO channel leading to the binding site suggesting a full release of curcumin from the cyclodextrin thereby allowing its full access to the active site of MPO.	Curcumin	123-131	myeloperoxidase	Homo sapiens	209-212
30624556-0	2019	Curcumin for Cognition: Is It Just Hype, Based on Current Data?	Curcumin	0-8	FIC domain protein adenylyltransferase	Homo sapiens	35-39
30551377-0	2019	Curcumin pretreatment protects against hypoxia/reoxgenation injury via improvement of mitochondrial function, destabilization of HIF-1alpha and activation of Epac1-Akt pathway in rat bone marrow mesenchymal stem cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	164-167
30551377-7	2019	In addition, curcumin pretreatment notably induced HIF-1alpha destabilization, Epac1 and Akt activation, and Erk1/2 and p38 deactivation.	Curcumin	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	89-92
30551377-8	2019	However, Epac1 inhibitor ESI-09 obviously restrained the increase of p-Akt induced by curcumin, but not p-Erk1/2 or p-p38, and abrogated the protective effect of curcumin on BMSCs" survival and arrested cell cycle in G0/G1 phase.	Curcumin	86-94	AKT serine/threonine kinase 1	Rattus norvegicus	71-74
30551377-9	2019	Taken together, these results demonstrated that curcumin pretreatment conferred BMSCs the ability to survive from H/R injury, which might attribute to its protection on mitochondrial function, destabilization of HIF-1alpha and activation of Epac1-Akt signaling pathway.	Curcumin	48-56	AKT serine/threonine kinase 1	Rattus norvegicus	247-250
30551471-10	2019	Inhibition of JAK/STAT pathway and activation of Nrf2/HO-1 pathway seems to be among the mechanisms mediating the effects of curcumin and metformin.	Curcumin	125-133	NFE2 like bZIP transcription factor 2	Rattus norvegicus	49-53
30395942-4	2019	The non-cytotoxic dose (IC20 values) of curcumin (WT1 and AP-1 inhibitors) was employed to examine its effect on WT1 gene-mediated WT1 and AP-1 protein expression.	Curcumin	40-48	WT1 transcription factor	Homo sapiens	50-53
30395942-4	2019	The non-cytotoxic dose (IC20 values) of curcumin (WT1 and AP-1 inhibitors) was employed to examine its effect on WT1 gene-mediated WT1 and AP-1 protein expression.	Curcumin	40-48	WT1 transcription factor	Homo sapiens	113-116
30395942-4	2019	The non-cytotoxic dose (IC20 values) of curcumin (WT1 and AP-1 inhibitors) was employed to examine its effect on WT1 gene-mediated WT1 and AP-1 protein expression.	Curcumin	40-48	WT1 transcription factor	Homo sapiens	113-116
30395942-6	2019	Curcumin, tanshinone IIA, and SP600125 inhibited WT1 protein expression in a dose-dependent manner (5-15 muM) at 24 h as shown by immunoblotting.	Curcumin	0-8	WT1 transcription factor	Homo sapiens	49-52
30395942-7	2019	A ChIP assay showed that curcumin and tanshinone IIA inhibited AP-1 and WT1 binding to the proximal WT1 promoter (-301 bp), and a luciferase reporter assay showed that the WT1 luciferase gene reporter activity was decreased after curcumin, tanshinone IIA, and SP600126 treatments.	Curcumin	25-33	WT1 transcription factor	Homo sapiens	72-75
30395942-7	2019	A ChIP assay showed that curcumin and tanshinone IIA inhibited AP-1 and WT1 binding to the proximal WT1 promoter (-301 bp), and a luciferase reporter assay showed that the WT1 luciferase gene reporter activity was decreased after curcumin, tanshinone IIA, and SP600126 treatments.	Curcumin	25-33	WT1 transcription factor	Homo sapiens	100-103
30395942-7	2019	A ChIP assay showed that curcumin and tanshinone IIA inhibited AP-1 and WT1 binding to the proximal WT1 promoter (-301 bp), and a luciferase reporter assay showed that the WT1 luciferase gene reporter activity was decreased after curcumin, tanshinone IIA, and SP600126 treatments.	Curcumin	25-33	WT1 transcription factor	Homo sapiens	100-103
30747066-0	2019	Anti-cancer Effects of Curcumin on Myelodysplastic Syndrome through the Inhibition of Enhancer of Zeste Homolog-2 (EZH2).	Curcumin	23-31	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	86-113
30747066-0	2019	Anti-cancer Effects of Curcumin on Myelodysplastic Syndrome through the Inhibition of Enhancer of Zeste Homolog-2 (EZH2).	Curcumin	23-31	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	115-119
30641821-8	2019	Curcumin reduce insulin resistance so decrease AGE"s products in diabetes mellitus.	Curcumin	0-8	insulin	Homo sapiens	16-23
31425942-0	2019	The effect of curcumin supplementation on circulating adiponectin: A systematic review and meta-analysis of randomized controlled trials.	Curcumin	14-22	adiponectin, C1Q and collagen domain containing	Homo sapiens	54-65
31425942-1	2019	OBJECTIVE: Our objective was to perform a systematic review and meta-analysis on randomized controlled trials (RCTs) assessing the effect of curcumin on serum adiponectin concentration.	Curcumin	141-149	adiponectin, C1Q and collagen domain containing	Homo sapiens	159-170
31425942-3	2019	RCTs conducted among human adults studied the effects of curcumin on serum adiponectin concentrations as an outcome variable was included.	Curcumin	57-65	adiponectin, C1Q and collagen domain containing	Homo sapiens	75-86
31425942-7	2019	The pooled results showed that curcumin supplementation significantly increased adiponectin concentrations in comparison with placebo (WMD: 0.82 Hedges" g; 95% confidence interval (CI): 0.33 to 1.30, P 0.001).	Curcumin	31-39	adiponectin, C1Q and collagen domain containing	Homo sapiens	80-91
31425942-9	2019	CONCLUSION: Curcumin significantly improves adiponectin concentrations.	Curcumin	12-20	adiponectin, C1Q and collagen domain containing	Homo sapiens	44-55
31425942-10	2019	However, due to some limitations in this study, further studies are needed to reach a definitive conclusion about the effect of curcumin on the levels of adiponectin.	Curcumin	128-136	adiponectin, C1Q and collagen domain containing	Homo sapiens	154-165
31660818-9	2019	Curcumin significantly reduced the levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-1beta, reactive oxygen species (ROS) and malondialdehyde (MDA) and increased the activity of superoxide dismutases (SOD) and catalase (CAT) in OGD/R-induced cells.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	45-78
31660818-9	2019	Curcumin significantly reduced the levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-1beta, reactive oxygen species (ROS) and malondialdehyde (MDA) and increased the activity of superoxide dismutases (SOD) and catalase (CAT) in OGD/R-induced cells.	Curcumin	0-8	interleukin 6	Rattus norvegicus	80-98
31660818-9	2019	Curcumin significantly reduced the levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-1beta, reactive oxygen species (ROS) and malondialdehyde (MDA) and increased the activity of superoxide dismutases (SOD) and catalase (CAT) in OGD/R-induced cells.	Curcumin	0-8	interleukin 1 alpha	Rattus norvegicus	100-108
31660818-9	2019	Curcumin significantly reduced the levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-1beta, reactive oxygen species (ROS) and malondialdehyde (MDA) and increased the activity of superoxide dismutases (SOD) and catalase (CAT) in OGD/R-induced cells.	Curcumin	0-8	catalase	Rattus norvegicus	228-236
31660818-9	2019	Curcumin significantly reduced the levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-1beta, reactive oxygen species (ROS) and malondialdehyde (MDA) and increased the activity of superoxide dismutases (SOD) and catalase (CAT) in OGD/R-induced cells.	Curcumin	0-8	catalase	Rattus norvegicus	238-241
30760195-4	2019	Omega- 3 fatty acids and curcumin, an active polyphenol of turmeric, have anti-inflammatory and neuroprotective effects through several mechanisms, including the suppression of COX-2 and iNOS gene expression, as well as their serum levels.	Curcumin	25-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
30760195-4	2019	Omega- 3 fatty acids and curcumin, an active polyphenol of turmeric, have anti-inflammatory and neuroprotective effects through several mechanisms, including the suppression of COX-2 and iNOS gene expression, as well as their serum levels.	Curcumin	25-33	nitric oxide synthase 2	Homo sapiens	187-191
30760195-9	2019	RESULTS: The results of the present trial showed that omega-3 fatty acids and nano-curcumin can reinforce each other"s effects in the downregulation of COX-2/iNOS mRNA, as well as reduce their serum levels.	Curcumin	83-91	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
30760195-9	2019	RESULTS: The results of the present trial showed that omega-3 fatty acids and nano-curcumin can reinforce each other"s effects in the downregulation of COX-2/iNOS mRNA, as well as reduce their serum levels.	Curcumin	83-91	nitric oxide synthase 2	Homo sapiens	158-162
31266378-4	2019	In this study, the cytotoxic effects of curcumin were investigated in gastric cancer AGS and SGC-7901 cell lines by MTT assay, and curcumin-induced morphological changes and cell apoptosis were assessed by using flow cytometry analysis and caspase-3 activity.	Curcumin	131-139	caspase 3	Homo sapiens	240-249
30651865-0	2019	Curcumin improves perfusion recovery in experimental peripheral arterial disease by upregulating microRNA-93 expression.	Curcumin	0-8	microRNA 9-3	Mus musculus	97-108
30651865-4	2019	However, the effects of curcumin on PAD under non-diabetic conditions has remained elusive, In the present study, mice with PAD and a normal glycaemic profile were treated with curcumin, which improved perfusion recovery, increased capillary density and elevated microRNA (miR)-93 expression in ischemic muscle tissue.	Curcumin	177-185	microRNA 9-3	Mus musculus	263-280
30651865-7	2019	Furthermore, in the presence of the miR-93 inhibitor, curcumin did not alter endothelial cell viability or tube formation.	Curcumin	54-62	microRNA 9-3	Mus musculus	36-42
30651865-8	2019	These results demonstrate that curcumin had beneficial effects in non-diabetic PAD by improving angiogenesis, which may have been achieved partially via the promotion of miR-93 expression.	Curcumin	31-39	microRNA 9-3	Mus musculus	170-176
30423402-0	2019	Tetrahydrocurcumin and octahydrocurcumin, the primary and final hydrogenated metabolites of curcumin, possess superior hepatic-protective effect against acetaminophen-induced liver injury: Role of CYP2E1 and Keap1-Nrf2 pathway.	Curcumin	10-18	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	197-203
30423402-0	2019	Tetrahydrocurcumin and octahydrocurcumin, the primary and final hydrogenated metabolites of curcumin, possess superior hepatic-protective effect against acetaminophen-induced liver injury: Role of CYP2E1 and Keap1-Nrf2 pathway.	Curcumin	10-18	kelch like ECH associated protein 1	Homo sapiens	208-213
30423402-0	2019	Tetrahydrocurcumin and octahydrocurcumin, the primary and final hydrogenated metabolites of curcumin, possess superior hepatic-protective effect against acetaminophen-induced liver injury: Role of CYP2E1 and Keap1-Nrf2 pathway.	Curcumin	10-18	NFE2 like bZIP transcription factor 2	Homo sapiens	214-218
30835338-0	2019	Thymoquinone and curcumin modify iNOS, caspase-3, and thioredoxin immunohistochemical expression in acetaminophen (APAP) hepatotoxicity.	Curcumin	17-25	nitric oxide synthase 2	Rattus norvegicus	33-37
30835338-0	2019	Thymoquinone and curcumin modify iNOS, caspase-3, and thioredoxin immunohistochemical expression in acetaminophen (APAP) hepatotoxicity.	Curcumin	17-25	thioredoxin 1	Rattus norvegicus	54-65
31266378-6	2019	As a result, we found that curcumin decreased cell viability and caused a dose-dependent cell apoptosis through the activation of caspase-3.	Curcumin	27-35	caspase 3	Homo sapiens	130-139
30542713-0	2019	Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	130-133
30145810-0	2019	Curcumin-mediated demethylation of the proximal promoter CpG island enhances the KLF4 recruitment that leads to increased expression of p21Cip1 in vitro.	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	136-143
30145810-5	2019	We probed the p21 promoter CGI (spanning from -135 to +12, respective to the transcription start site) to detect alterations in cytosine methylation level in response to curcumin exposure in four different human cancer cell lines: A431, A549, MCF7, and HeLa.	Curcumin	170-178	cyclin dependent kinase inhibitor 1A	Homo sapiens	14-17
30145810-6	2019	We observed curcumin (20 microM) treatment significantly increased the expression of p21, and the promoter CGI was demethylated in a dose-dependent manner.	Curcumin	12-20	cyclin dependent kinase inhibitor 1A	Homo sapiens	85-88
30145810-7	2019	The curcumin significantly raised the level KLF4 and enhanced the p21 promoter occupancy by KLF4.	Curcumin	4-12	cyclin dependent kinase inhibitor 1A	Homo sapiens	66-69
30145810-8	2019	From our results we hypothesize that curcumin-mediated demethylation of the p21 proximal promoter and increased KLF4 expression as well as its binding to its proximal promoter could serve as a mechanism that could be hypothesized to cause upregulation of p21 in presence of curcumin and thus its therapeutic implications could further be investigated.	Curcumin	37-45	cyclin dependent kinase inhibitor 1A	Homo sapiens	76-79
30145810-8	2019	From our results we hypothesize that curcumin-mediated demethylation of the p21 proximal promoter and increased KLF4 expression as well as its binding to its proximal promoter could serve as a mechanism that could be hypothesized to cause upregulation of p21 in presence of curcumin and thus its therapeutic implications could further be investigated.	Curcumin	37-45	cyclin dependent kinase inhibitor 1A	Homo sapiens	255-258
30145810-8	2019	From our results we hypothesize that curcumin-mediated demethylation of the p21 proximal promoter and increased KLF4 expression as well as its binding to its proximal promoter could serve as a mechanism that could be hypothesized to cause upregulation of p21 in presence of curcumin and thus its therapeutic implications could further be investigated.	Curcumin	274-282	cyclin dependent kinase inhibitor 1A	Homo sapiens	76-79
31287789-11	2019	Furthermore, IFN-alpha/beta levels induced by TLR4 and IRF3 were decreased in these cells following curcumin treatment.	Curcumin	100-108	interferon alpha 1	Homo sapiens	13-22
31287789-12	2019	CONCLUSIONS: Consequently, these results demonstrated that the activation of LPS stimulated TLR4/TRIF/IRF3 signaling pathway was mediated by curcumin in breast cancer cells, in vitro.	Curcumin	141-149	TIR domain containing adaptor molecule 1	Homo sapiens	97-101
31287789-13	2019	However, more studies are necessary to examine the curcumin"s anti-inflammatory activities on TLR4/MyD88/NF-kappaB as well as other signaling pathways downstream of TLRs in breast cancer.	Curcumin	51-59	nuclear factor kappa B subunit 1	Homo sapiens	105-114
30655747-13	2019	Curcumin treatment significantly downregulated B-cell lymphoma-2 (Bcl-2) at the mRNA and protein levels, but upregulated Bcl-2-associated X.	Curcumin	0-8	B cell leukemia/lymphoma 2	Mus musculus	47-64
30655747-13	2019	Curcumin treatment significantly downregulated B-cell lymphoma-2 (Bcl-2) at the mRNA and protein levels, but upregulated Bcl-2-associated X.	Curcumin	0-8	B cell leukemia/lymphoma 2	Mus musculus	66-71
30655747-13	2019	Curcumin treatment significantly downregulated B-cell lymphoma-2 (Bcl-2) at the mRNA and protein levels, but upregulated Bcl-2-associated X.	Curcumin	0-8	B cell leukemia/lymphoma 2	Mus musculus	121-126
31679307-8	2019	Curcumin efficiently inhibited HCC cell proliferation by blocking the Wnt/beta-catenin pathway and inhabited migration and invasion by blocking the TGF-p/EMT signal pathway.	Curcumin	0-8	IL2 inducible T cell kinase	Mus musculus	154-157
30393127-2	2019	In prior experiments, turmeric-derived curcumin inhibited in vivo BMET progression and in vitro TGFbeta/Smad-signaling in a TGFbeta-stimulated PTHrP-dependent human xenograft BCa BMET model (MDA-SA cells).	Curcumin	39-47	parathyroid hormone-like peptide	Mus musculus	143-148
30393127-6	2019	Similarly, curcumin, but not curcumin-glucuronide, blocked TGFbeta-stimulated secretion of PTHrP from MDA-SA and 4T1 cells.	Curcumin	11-19	parathyroid hormone-like peptide	Mus musculus	91-96
31287789-0	2019	Inhibition of TLR4/TRIF/IRF3 Signaling Pathway by Curcumin in Breast Cancer Cells.	Curcumin	50-58	TIR domain containing adaptor molecule 1	Homo sapiens	19-23
31287789-5	2019	For this purpose, we explored the inhibitory effects of curcumin on lipopolysaccharide (LPS)-induced TLR4 dependent TRIF signaling pathway in two subtypes of breast cancer cell lines (MCF-7 and MDA-MB-231) in this study.	Curcumin	56-64	TIR domain containing adaptor molecule 1	Homo sapiens	116-120
31287789-7	2019	The expression level of TLR4 and the release of type I interferon (IFN) levels were determined after treatment with curcumin and/or LPS by RT-PCR and ELISA analysis, respectively.	Curcumin	116-124	interferon alpha 1	Homo sapiens	48-71
31287789-9	2019	RESULTS: Curcumin treatment suppressed breast cancer cells viabilities and the activation of TLR4-mediated TRIF signaling pathway by the downregulation of TLR4 and IRF3 expression levels and the inhibition of type I IFN (IFN-alpha/beta) levels induced by LPS.	Curcumin	9-17	TIR domain containing adaptor molecule 1	Homo sapiens	107-111
31287789-9	2019	RESULTS: Curcumin treatment suppressed breast cancer cells viabilities and the activation of TLR4-mediated TRIF signaling pathway by the downregulation of TLR4 and IRF3 expression levels and the inhibition of type I IFN (IFN-alpha/beta) levels induced by LPS.	Curcumin	9-17	interferon alpha 1	Homo sapiens	216-219
31287789-9	2019	RESULTS: Curcumin treatment suppressed breast cancer cells viabilities and the activation of TLR4-mediated TRIF signaling pathway by the downregulation of TLR4 and IRF3 expression levels and the inhibition of type I IFN (IFN-alpha/beta) levels induced by LPS.	Curcumin	9-17	interferon alpha 1	Homo sapiens	221-230
30483727-5	2019	Curcumin targets numerous signaling pathways associated with cancer therapy, including pathways mediated by p53, Ras, phosphatidylinositol-3-kinase, protein kinase B, Wnt-beta catenin and mammalian target of rapamycin.	Curcumin	0-8	tumor protein p53	Homo sapiens	108-111
30483727-5	2019	Curcumin targets numerous signaling pathways associated with cancer therapy, including pathways mediated by p53, Ras, phosphatidylinositol-3-kinase, protein kinase B, Wnt-beta catenin and mammalian target of rapamycin.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	188-217
31064708-9	2019	CONCLUSION: This meta-analysis showed a significant increase in plasma levels of adiponectin following curcuminoids therapy, which may be one of the mechanisms of anti-inflammatory activity of curcumin.	Curcumin	103-111	adiponectin, C1Q and collagen domain containing	Homo sapiens	81-92
30542713-14	2019	Taken together, the present study indicates that curcumin suppresses hyperglycemia-driven EGF-induced invasion and migration of pancreatic cancer cells by inhibiting the EGF/EGFR signaling pathway and its downstream signaling molecules including ERK and Akt.	Curcumin	49-57	epidermal growth factor receptor	Homo sapiens	174-178
30542713-14	2019	Taken together, the present study indicates that curcumin suppresses hyperglycemia-driven EGF-induced invasion and migration of pancreatic cancer cells by inhibiting the EGF/EGFR signaling pathway and its downstream signaling molecules including ERK and Akt.	Curcumin	49-57	mitogen-activated protein kinase 1	Homo sapiens	246-249
30542713-14	2019	Taken together, the present study indicates that curcumin suppresses hyperglycemia-driven EGF-induced invasion and migration of pancreatic cancer cells by inhibiting the EGF/EGFR signaling pathway and its downstream signaling molecules including ERK and Akt.	Curcumin	49-57	AKT serine/threonine kinase 1	Homo sapiens	254-257
30542713-0	2019	Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	138-141
30542713-5	2019	As high glucose is able to induce the expression of epidermal growth factor (EGF), which is intimately related with tumor progression, the aim of this study was to evaluate whether curcumin could influence the high glucose-induced EGF/EGFR pathway and the biological activity of pancreatic cancer cells.	Curcumin	181-189	epidermal growth factor receptor	Homo sapiens	235-239
30542713-13	2019	In addition, EGF-modulated activation of EGFR, ERK and Akt, as well as the expression of uPA and E-cadherin were inhibited by curcumin.	Curcumin	126-134	epidermal growth factor receptor	Homo sapiens	41-45
30542713-13	2019	In addition, EGF-modulated activation of EGFR, ERK and Akt, as well as the expression of uPA and E-cadherin were inhibited by curcumin.	Curcumin	126-134	mitogen-activated protein kinase 1	Homo sapiens	47-50
30542713-13	2019	In addition, EGF-modulated activation of EGFR, ERK and Akt, as well as the expression of uPA and E-cadherin were inhibited by curcumin.	Curcumin	126-134	AKT serine/threonine kinase 1	Homo sapiens	55-58
30542713-13	2019	In addition, EGF-modulated activation of EGFR, ERK and Akt, as well as the expression of uPA and E-cadherin were inhibited by curcumin.	Curcumin	126-134	proline rich acidic protein 1	Homo sapiens	89-92
30542713-13	2019	In addition, EGF-modulated activation of EGFR, ERK and Akt, as well as the expression of uPA and E-cadherin were inhibited by curcumin.	Curcumin	126-134	cadherin 1	Homo sapiens	97-107
30943499-10	2019	In addition, curcumin treatment significantly decreased the levels of TNF-alpha and IL-6 in rat spinal cords that were exceedingly upregulated in the BPA group.	Curcumin	13-21	tumor necrosis factor	Rattus norvegicus	70-79
30943499-10	2019	In addition, curcumin treatment significantly decreased the levels of TNF-alpha and IL-6 in rat spinal cords that were exceedingly upregulated in the BPA group.	Curcumin	13-21	interleukin 6	Rattus norvegicus	84-88
30599890-10	2019	Further investigation of the mechanism of action of curcumin and quercetin in melanoma cells, A375, suggested that inhibition of cell proliferation occurred through down-regulation of Wnt/beta-catenin signaling pathway proteins, DVL2, beta-catenin, cyclin D1, Cox2, and Axin2.	Curcumin	52-60	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	260-264
30655872-0	2019	Curcumin-induced promoter hypermethylation of the mammalian target of rapamycin gene in multiple myeloma cells.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	50-79
30655872-3	2019	The curcumin-induced epigenetic regulation of mTOR, including promoter DNA methylation in multiple myeloma, has not yet been fully elucidated.	Curcumin	4-12	mechanistic target of rapamycin kinase	Homo sapiens	46-50
30599909-7	2019	RESULTS: Our results showed that Curcumin markedly reduced the mRNA expression and secretion of IL-1beta, IL-6, TNFalpha and MCP-1 in LPS stimulated RAW264.7 cell and the supernatant.	Curcumin	33-41	interleukin 1 beta	Mus musculus	96-104
30655872-7	2019	Following curcumin treatment, the mRNA and protein expression levels of mTOR were decreased by 43.31 and 39.34% in NCI-H929 cells, respectively.	Curcumin	10-18	mechanistic target of rapamycin kinase	Homo sapiens	72-76
30655872-8	2019	The promoter of mTOR, located in chromosome 1 (chromosome position, 11262153-11263153), contains a CpG island that was hypermethylated in myeloma cells following curcumin treatment.	Curcumin	162-170	mechanistic target of rapamycin kinase	Homo sapiens	16-20
30655872-10	2019	Collectively, these results indicate that curcumin serves a role in the epigenetic regulation of mTOR expression, and that mTOR downregulation is due to promoter hypermethylation, which may be associated with DNMT3a and DNMT3b upregulation.	Curcumin	42-50	mechanistic target of rapamycin kinase	Homo sapiens	97-101
30599909-7	2019	RESULTS: Our results showed that Curcumin markedly reduced the mRNA expression and secretion of IL-1beta, IL-6, TNFalpha and MCP-1 in LPS stimulated RAW264.7 cell and the supernatant.	Curcumin	33-41	interleukin 6	Mus musculus	106-110
30599909-7	2019	RESULTS: Our results showed that Curcumin markedly reduced the mRNA expression and secretion of IL-1beta, IL-6, TNFalpha and MCP-1 in LPS stimulated RAW264.7 cell and the supernatant.	Curcumin	33-41	tumor necrosis factor	Mus musculus	112-120
30599909-9	2019	The data also demonstrated that Curcumin remarkably down-regulated mRNA expression and protein level of Mincle in cis-AKI kidney and also reduced expression of iNOS (M1 macrophage marker) as well as inhibited the activation of Syk and NF-kB.	Curcumin	32-40	nitric oxide synthase 2, inducible	Mus musculus	160-164
30599909-10	2019	Interestingly, although Mincle deletion in RAW264.7 cell largely decreased the LPS-induced protein level of iNOS, Curcumin cannot further reduce expression of iNOS without Mincle, indicating that Curcumin inhibits M1 macrophage with a Mincle-dependent pattern.	Curcumin	114-122	nitric oxide synthase 2, inducible	Mus musculus	159-163
30599909-10	2019	Interestingly, although Mincle deletion in RAW264.7 cell largely decreased the LPS-induced protein level of iNOS, Curcumin cannot further reduce expression of iNOS without Mincle, indicating that Curcumin inhibits M1 macrophage with a Mincle-dependent pattern.	Curcumin	196-204	nitric oxide synthase 2, inducible	Mus musculus	108-112
30599909-11	2019	Furthermore, flow cytometry results showed that Curcumin significantly decreased the iNOS positive macrophages and increased the CD206 (M2 macrophage marker) positive macrophages in vivo and in vitro.	Curcumin	48-56	nitric oxide synthase 2, inducible	Mus musculus	85-89
30599890-11	2019	In addition, both curcumin and quercetin induced apoptosis by down-regulating BCL2 and inducing caspase 3/7 through PARP cleavage.	Curcumin	18-26	BCL2 apoptosis regulator	Homo sapiens	78-82
30599890-11	2019	In addition, both curcumin and quercetin induced apoptosis by down-regulating BCL2 and inducing caspase 3/7 through PARP cleavage.	Curcumin	18-26	caspase 3	Homo sapiens	96-105
30599892-0	2019	Curcumin ameliorates atherosclerosis in apolipoprotein E deficient asthmatic mice by regulating the balance of Th2/Treg cells.	Curcumin	0-8	apolipoprotein E	Mus musculus	40-56
30599892-7	2019	Although curcumin treatment markedly reduced the interleukin (IL)-4 and IL-13 in serum and spleen, the elevated IL-17A did not decrease.	Curcumin	9-17	interleukin 13	Mus musculus	72-77
30599892-9	2019	The mRNA expression levels of M1 macrophage-related inflammatory factors IL-6, iNOS and IL-1beta were markedly elevated in the spleens of asthmatic mice, but significantly decreased after the 8-week treatment with curcumin.	Curcumin	214-222	interleukin 6	Mus musculus	73-77
30599892-9	2019	The mRNA expression levels of M1 macrophage-related inflammatory factors IL-6, iNOS and IL-1beta were markedly elevated in the spleens of asthmatic mice, but significantly decreased after the 8-week treatment with curcumin.	Curcumin	214-222	nitric oxide synthase 2, inducible	Mus musculus	79-83
30599892-9	2019	The mRNA expression levels of M1 macrophage-related inflammatory factors IL-6, iNOS and IL-1beta were markedly elevated in the spleens of asthmatic mice, but significantly decreased after the 8-week treatment with curcumin.	Curcumin	214-222	interleukin 1 beta	Mus musculus	88-96
30599892-10	2019	CONCLUSION: Curcumin ameliorated the aggravation of atherosclerotic lesions and stabilised plaque by modulating the balance of Th2/Tregs in asthmatic apoE-/- mice.	Curcumin	12-20	apolipoprotein E	Mus musculus	150-154
30728952-5	2018	The translocation of Nrf2 to the nucleus after exposure of HepG2 cells to the extracts and controls (alpha-lipoic acid, curcumin and hydrogen peroxide) was evaluated using the Nrf2 transcription factor kit.	Curcumin	120-128	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
30053224-8	2019	The gene expression levels of fatty acid synthase (FAS) and sterol regulatory element binding protein-1c (SREBP-1c) were significantly decreased in all curcumin groups (P &lt; 0.05), but the gene expression levels of acetyl CoA carboxylase (ACC) and ATP-citrate lyase (ACLY) were significantly decreased only in the 2,000 mg/kg curcumin group (P &lt; 0.05).	Curcumin	152-160	ATP citrate lyase	Gallus gallus	250-267
30053224-8	2019	The gene expression levels of fatty acid synthase (FAS) and sterol regulatory element binding protein-1c (SREBP-1c) were significantly decreased in all curcumin groups (P &lt; 0.05), but the gene expression levels of acetyl CoA carboxylase (ACC) and ATP-citrate lyase (ACLY) were significantly decreased only in the 2,000 mg/kg curcumin group (P &lt; 0.05).	Curcumin	152-160	ATP citrate lyase	Gallus gallus	269-273
30053224-9	2019	The expression levels of peroxisome proliferators-activated receptor alpha (PPARalpha) and carnitine palmitoyl transferase-I (CPT-I) were significantly increased in the 1,000 and 2,000 mg/kg curcumin groups (P &lt; 0.05).	Curcumin	191-199	peroxisome proliferator activated receptor alpha	Gallus gallus	76-85
30053224-10	2019	These results indicated that curcumin plays an important role in reduction abdominal fat deposition by decreasing the hepatic and plasma lipid profile and affecting the expression levels of genes related to lipogenesis and lipolysis including ACC, FAS, SREBP-1c, ACLY, PPARalpha, and CPT-I.	Curcumin	29-37	ATP citrate lyase	Gallus gallus	263-267
30053224-10	2019	These results indicated that curcumin plays an important role in reduction abdominal fat deposition by decreasing the hepatic and plasma lipid profile and affecting the expression levels of genes related to lipogenesis and lipolysis including ACC, FAS, SREBP-1c, ACLY, PPARalpha, and CPT-I.	Curcumin	29-37	peroxisome proliferator activated receptor alpha	Gallus gallus	269-278
30693069-5	2018	The aim of this study is to evaluate the effect of curcumin in preventive and therapeutic approaches against oxidative damage, NF-kappaB activation, and the rise in serum levels of IL-1beta and TNF-alpha induced by acute and chronic exposure to ozone in rat hippocampus.	Curcumin	51-59	interleukin 1 beta	Rattus norvegicus	181-189
30693069-5	2018	The aim of this study is to evaluate the effect of curcumin in preventive and therapeutic approaches against oxidative damage, NF-kappaB activation, and the rise in serum levels of IL-1beta and TNF-alpha induced by acute and chronic exposure to ozone in rat hippocampus.	Curcumin	51-59	tumor necrosis factor	Rattus norvegicus	194-203
30567342-6	2018	Our predictions were in agreement with the scientific literature and confirmed that curcumin binds to folate receptor beta, DNA (cytosine-5)-methyltransferase 3A, metalloproteinase-2, mitogen-activated protein kinase 9, epidermal growth factor receptor and apoptosis-inducing factor 1.	Curcumin	84-92	mitogen-activated protein kinase 9	Homo sapiens	124-218
30534000-6	2018	Curcumin also activated the expression of apoptotic proteins, such as polyADP ribose polymerase, caspase-3, and caspase-9.	Curcumin	0-8	caspase 3	Homo sapiens	97-106
30321530-0	2018	Curcumin ameliorates scopolamine-induced mice memory retrieval deficit and restores hippocampal p-Akt and p-GSK-3beta.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	98-101
30321530-13	2018	The results showed that curcumin treatment at 50 and 100 mg/kg doses prevented scopolamine-induced memory retrieval deficit and restored Akt and GSK dephosphorylation caused by scopolamine.	Curcumin	24-32	thymoma viral proto-oncogene 1	Mus musculus	137-140
30526546-8	2018	Curcumin suppressed the phosphorylation levels of JAK1, STAT1, and STAT3, while curcumin did not inhibit the activation of JAK/STAT pathway when miR-99a was knocked down.	Curcumin	0-8	Janus kinase 1	Homo sapiens	50-54
30526546-8	2018	Curcumin suppressed the phosphorylation levels of JAK1, STAT1, and STAT3, while curcumin did not inhibit the activation of JAK/STAT pathway when miR-99a was knocked down.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	67-72
30253824-0	2018	Curcumin-graphene quantum dots for dual mode sensing platform: Electrochemical and fluorescence detection of APOe4, responsible of Alzheimer"s disease.	Curcumin	0-8	apolipoprotein E	Homo sapiens	109-114
30253824-1	2018	New dual electrochemical and fluorescence sensitive curcumin-graphene quantum dots sensing platform coated on the transparent Indium-Tin-Oxide electrode was developed to sense APOe4 DNA, responsible of Alzheimer"s disease.	Curcumin	52-60	apolipoprotein E	Homo sapiens	176-181
30253824-4	2018	Quenching of curcumin signals following hybridized DNA complex was employed to quantify APOe4 DNA.	Curcumin	13-21	apolipoprotein E	Homo sapiens	88-93
30403471-6	2018	A two-stage augmented photothermal conversion capability is introduced to this nanosystem by encapsulating curcumin in MIL-100 pores and then coating HA-PDA on the surface, which confer the MCH NPs with strong photothermal conversional efficiency.	Curcumin	107-115	modifier of chinchilla	Mus musculus	190-193
30559668-5	2018	The minor curcumin constituent, bisdemethoxycurcumin (BDC) showed the most potent protective action to decrease levels of NF-kappaB and BACE1, decrease the inflammatory cascade and diminish Abeta aggregates in cells from AD patients.	Curcumin	10-18	beta-secretase 1	Homo sapiens	136-141
30468567-6	2018	In vitro and in vivo studies on the nanofibrous memembrane-coating demonstrate improved antitumor effects for the CUR/5-FU dual drug system which can be attributed to cell cycle arrest in the S phase in association with induced apoptosis in tumor cells by blocking signal transducer and activator of transcription3 (Stat3) and nuclear factor kappa beta (NF-kB) signaling pathways, suggesting potential in the treatment of CRC in the future.	Curcumin	114-117	signal transducer and activator of transcription 3	Homo sapiens	265-314
30584274-9	2018	Curcumin and rapamycin treatment inhibited the increased levels of proinflammatory cytokines including IL-1beta, TNF-alpha, MMP-1, and MMP-3 in CIA rats.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	103-111
30584274-9	2018	Curcumin and rapamycin treatment inhibited the increased levels of proinflammatory cytokines including IL-1beta, TNF-alpha, MMP-1, and MMP-3 in CIA rats.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	113-122
30468567-6	2018	In vitro and in vivo studies on the nanofibrous memembrane-coating demonstrate improved antitumor effects for the CUR/5-FU dual drug system which can be attributed to cell cycle arrest in the S phase in association with induced apoptosis in tumor cells by blocking signal transducer and activator of transcription3 (Stat3) and nuclear factor kappa beta (NF-kB) signaling pathways, suggesting potential in the treatment of CRC in the future.	Curcumin	114-117	signal transducer and activator of transcription 3	Homo sapiens	316-321
30297285-0	2018	Design, synthesis and evaluation of curcumin-based fluorescent probes to detect Abeta fibrils.	Curcumin	36-44	amyloid beta precursor protein	Homo sapiens	80-85
29183161-3	2018	The effects of curcumin-encapsulated HA-PLA NPs on the viability of LPS/IFN-gamma stimulated peritoneal macrophages were determined using MTT assay.	Curcumin	15-23	interferon gamma	Homo sapiens	72-81
29183161-8	2018	The change in macrophage phenotype by curcumin-encapsulated HA-PLA NPs could suppress the inflammation in LPS/IFN-gamma stimulated macrophages as evidenced by a major reduction in pro-inflammatory cytokines.	Curcumin	38-46	interferon gamma	Homo sapiens	110-119
30518397-0	2018	The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma.	Curcumin	23-31	signal transducer and activator of transcription 3	Mus musculus	65-70
30518397-3	2018	METHODS: Luciferase assay and immunoblotting were performed to examine whether curcumin suppressed STAT3 signaling.	Curcumin	79-87	signal transducer and activator of transcription 3	Mus musculus	99-104
30518397-11	2018	RESULTS: The natural polyphenol curcumin inhibited STAT3 phosphorylation rapidly and blocked STAT3-mediated signaling in ESCC cells.	Curcumin	32-40	signal transducer and activator of transcription 3	Mus musculus	51-56
30518397-11	2018	RESULTS: The natural polyphenol curcumin inhibited STAT3 phosphorylation rapidly and blocked STAT3-mediated signaling in ESCC cells.	Curcumin	32-40	signal transducer and activator of transcription 3	Mus musculus	93-98
30518397-13	2018	Furthermore, curcumin preferentially blocked the growth of primary ESCC-derived xenografts that harbored activated STAT3.	Curcumin	13-21	signal transducer and activator of transcription 3	Mus musculus	115-120
30518397-14	2018	CONCLUSIONS: Curcumin is able to exert anti-tumor action through inhibiting the STAT3 signaling pathway.	Curcumin	13-21	signal transducer and activator of transcription 3	Mus musculus	80-85
30518397-15	2018	Giving its wide use in traditional medicines with low toxicity and few adverse reactions, it is conceivable that curcumin might be further explored as a unique STAT3 inhibitor for anti-cancer therapies.	Curcumin	113-121	signal transducer and activator of transcription 3	Mus musculus	160-165
30134219-15	2018	Both curcumin-loaded liposomes formulation (1 mug/mL, 5 mug/mL) resulted in significant (p &lt; 0.05) reduction in the level of pro-inflammatory marker expression such as IL-6, IL-8, IL-1beta and TNF-a compared to positive control group.	Curcumin	5-13	interleukin 6	Homo sapiens	171-175
30134219-15	2018	Both curcumin-loaded liposomes formulation (1 mug/mL, 5 mug/mL) resulted in significant (p &lt; 0.05) reduction in the level of pro-inflammatory marker expression such as IL-6, IL-8, IL-1beta and TNF-a compared to positive control group.	Curcumin	5-13	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
30134219-15	2018	Both curcumin-loaded liposomes formulation (1 mug/mL, 5 mug/mL) resulted in significant (p &lt; 0.05) reduction in the level of pro-inflammatory marker expression such as IL-6, IL-8, IL-1beta and TNF-a compared to positive control group.	Curcumin	5-13	interleukin 1 beta	Homo sapiens	183-191
30134219-15	2018	Both curcumin-loaded liposomes formulation (1 mug/mL, 5 mug/mL) resulted in significant (p &lt; 0.05) reduction in the level of pro-inflammatory marker expression such as IL-6, IL-8, IL-1beta and TNF-a compared to positive control group.	Curcumin	5-13	tumor necrosis factor	Homo sapiens	196-201
31949668-9	2018	CONCLUSION: Curcumin had anti-tumor effects to gastric cancer via ion of miRNA-21 by regulation of the PTEN/PI3K/AKT pathway.	Curcumin	12-20	AKT serine/threonine kinase 1	Homo sapiens	113-116
30380516-15	2018	Our study demonstrates that the nanoformulation of curcumin can reduce pro-inflammatory mediators in S. aureus-infected mammary tissues by improving NF-kappaB signaling.	Curcumin	51-59	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	149-158
30111198-0	2018	Curcumin as a therapeutic agent for blocking NF-kappaB activation in ulcerative colitis.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	45-54
30111198-6	2018	This review aims to describe the complex role of NF-kappaB in UC and discuss existing pharmacological attempts by curcumin for blocking NF-kappaB activation to develop new therapeutic strategies in UC.	Curcumin	114-122	nuclear factor kappa B subunit 1	Homo sapiens	136-145
30111198-7	2018	Several studies have shown intriguing pharmacologic effects associated with curcumin, which inhibits NF-kappaB expression by regulating NF-kappaB/IkB pathway and down-regulation expression of pro-inflammatory cytokines, such as Interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha.	Curcumin	76-84	nuclear factor kappa B subunit 1	Homo sapiens	101-110
30111198-7	2018	Several studies have shown intriguing pharmacologic effects associated with curcumin, which inhibits NF-kappaB expression by regulating NF-kappaB/IkB pathway and down-regulation expression of pro-inflammatory cytokines, such as Interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha.	Curcumin	76-84	nuclear factor kappa B subunit 1	Homo sapiens	136-145
30111198-7	2018	Several studies have shown intriguing pharmacologic effects associated with curcumin, which inhibits NF-kappaB expression by regulating NF-kappaB/IkB pathway and down-regulation expression of pro-inflammatory cytokines, such as Interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha.	Curcumin	76-84	interleukin 6	Homo sapiens	248-252
30111198-7	2018	Several studies have shown intriguing pharmacologic effects associated with curcumin, which inhibits NF-kappaB expression by regulating NF-kappaB/IkB pathway and down-regulation expression of pro-inflammatory cytokines, such as Interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha.	Curcumin	76-84	C-X-C motif chemokine ligand 8	Homo sapiens	254-258
30111198-7	2018	Several studies have shown intriguing pharmacologic effects associated with curcumin, which inhibits NF-kappaB expression by regulating NF-kappaB/IkB pathway and down-regulation expression of pro-inflammatory cytokines, such as Interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha.	Curcumin	76-84	tumor necrosis factor	Homo sapiens	264-297
30111198-10	2018	The inhibitory effects of curcumin on NF-kappaB and its unrivaled safety profile indicate that it remains effective for the treatment of UC.	Curcumin	26-34	nuclear factor kappa B subunit 1	Homo sapiens	38-47
30272283-12	2018	Further analysis revealed that curcumin may act as a PI3K-Akt-mTOR signaling pathway inhibitor by downregulating PI3K, p-Akt, p-mTOR and p-p70 ribosomal protein S6 kinase.	Curcumin	31-39	AKT serine/threonine kinase 1	Homo sapiens	58-61
30272283-12	2018	Further analysis revealed that curcumin may act as a PI3K-Akt-mTOR signaling pathway inhibitor by downregulating PI3K, p-Akt, p-mTOR and p-p70 ribosomal protein S6 kinase.	Curcumin	31-39	mechanistic target of rapamycin kinase	Homo sapiens	62-66
30272283-12	2018	Further analysis revealed that curcumin may act as a PI3K-Akt-mTOR signaling pathway inhibitor by downregulating PI3K, p-Akt, p-mTOR and p-p70 ribosomal protein S6 kinase.	Curcumin	31-39	AKT serine/threonine kinase 1	Homo sapiens	121-124
30272283-12	2018	Further analysis revealed that curcumin may act as a PI3K-Akt-mTOR signaling pathway inhibitor by downregulating PI3K, p-Akt, p-mTOR and p-p70 ribosomal protein S6 kinase.	Curcumin	31-39	mechanistic target of rapamycin kinase	Homo sapiens	128-132
29339038-0	2018	Curcumin inhibits TGF-beta1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	18-27
30539870-0	2018	Combinatorial effect of curcumin and tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) in induction of apoptosis via inhibition of nuclear factor kappa activity and enhancement of caspase-3 activity in chronic myeloid cells: An In-vitro study.	Curcumin	24-32	caspase 3	Homo sapiens	200-209
30539870-8	2018	Curcumin and TRAIL enhanced the caspase-3 activity as compared to caspase-8 and caspase-9.	Curcumin	0-8	caspase 3	Homo sapiens	32-41
30539870-10	2018	Conclusion: Our results conclude that curcumin and TRAIL effectively induce the apoptosis through the inhibition of NFkB activity and by enhancing the caspase-3 activity.	Curcumin	38-46	caspase 3	Homo sapiens	151-160
30320490-0	2018	Cardioprotective effects of the novel curcumin analogue C66 in diabetic mice is dependent on JNK2 inactivation.	Curcumin	38-46	mitogen-activated protein kinase 9	Mus musculus	93-97
29339038-5	2018	This study was aimed to evaluate whether curcumin could suppress TGF-beta1-induced CTGF expression and its related signaling pathway involving in this inhibitory action in primary human gingival fibroblasts.	Curcumin	41-49	transforming growth factor beta 1	Homo sapiens	65-74
29339038-8	2018	The effect of curcumin on TGF-beta1-induced CTGF expression in primary human gingival fibroblasts was examined by immunoblotting.	Curcumin	14-22	transforming growth factor beta 1	Homo sapiens	26-35
29339038-12	2018	Curcumin was nontoxic and could reduce TGF-beta1-induced CTGF expression by attenuating the phosphorylation and nuclear translocation of Smad2.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	39-48
29339038-13	2018	CONCLUSION: Curcumin can suppress TGF-beta1-induced CTGF expression through the interruption of Smad2 signaling.	Curcumin	12-20	transforming growth factor beta 1	Homo sapiens	34-43
30396035-0	2018	Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1beta production.	Curcumin	0-8	interleukin 1 beta	Mus musculus	88-96
30251185-5	2018	By treatment with inflammatory cytokines IL-1beta, TNFalpha or TGF-beta after treatment with or without the NF-kappaB inhibitor curcumin, curucumin blocked the production and secretion of IL-6 upregulated by IL-1beta, TNFalpha, or TNFalpha/TGF-beta in all fibroblasts.	Curcumin	128-136	interleukin 6	Homo sapiens	188-192
30251185-7	2018	IL-33 in affected fibroblasts was induced by IL-1beta, TNFalpha, or TNFalpha/TGF-beta, while the effect of IL-1beta or TNFalpha/TGF-beta was blocked by curcumin.	Curcumin	152-160	interleukin 1 beta	Homo sapiens	107-115
30251185-7	2018	IL-33 in affected fibroblasts was induced by IL-1beta, TNFalpha, or TNFalpha/TGF-beta, while the effect of IL-1beta or TNFalpha/TGF-beta was blocked by curcumin.	Curcumin	152-160	transforming growth factor beta 1	Homo sapiens	128-136
30143976-0	2018	Curcumin confers hepatoprotection against AFB1-induced toxicity via activating autophagy and ameliorating inflammation involving Nrf2/HO-1 signaling pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
30143976-7	2018	Intriguingly, dietary curcumin supplementation modulated autophagy through the activation of beclin-1, ATG5, Dynein, LC3a, LC3b-I/II and downregulation of p53 &amp; mTOR expression level.	Curcumin	22-30	autophagy related 5	Homo sapiens	103-107
30143976-7	2018	Intriguingly, dietary curcumin supplementation modulated autophagy through the activation of beclin-1, ATG5, Dynein, LC3a, LC3b-I/II and downregulation of p53 &amp; mTOR expression level.	Curcumin	22-30	tumor protein p53	Homo sapiens	155-158
30143976-7	2018	Intriguingly, dietary curcumin supplementation modulated autophagy through the activation of beclin-1, ATG5, Dynein, LC3a, LC3b-I/II and downregulation of p53 &amp; mTOR expression level.	Curcumin	22-30	mechanistic target of rapamycin kinase	Homo sapiens	165-169
30143976-9	2018	Moreover, curcumin treatment significantly (p &lt; 0.05) elevated AFB1-induced decrease in Nrf2 and HO-1 mRNA and protein expression level.	Curcumin	10-18	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
30143976-10	2018	In summary, curcumin activated autophagy and ameliorated inflammation involving Nrf2 signaling pathway which may become a new targeted therapy to prevent AFB1-induced hepatotoxicity.	Curcumin	12-20	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84
30365132-0	2018	Nrf2 is a key factor in the reversal effect of curcumin on multidrug resistance in the HCT-8/5-Fu human colorectal cancer cell line.	Curcumin	47-55	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
30365132-8	2018	These results indicated that Nrf2 may have a functional in the reversal effect of curcumin and contribute, at least in part, to the outcomes of chemotherapy in patients with MDR.	Curcumin	82-90	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
30396035-3	2018	OBJECTIVE: The present study was to investigate the protective effects of curcumin on dextran sulfate sodium (DSS)-induced colitis through inhibiting NLRP3 inflammasome activation and IL-1beta production.	Curcumin	74-82	interleukin 1 beta	Mus musculus	184-192
30396035-4	2018	METHODS: LPS-primed macrophages were treated with curcumin prior to DSS triggering NLRP3 inflammasome activation, IL-1beta secretion and ASC oligomerization were observed.	Curcumin	50-58	interleukin 1 beta	Mus musculus	114-122
30396035-9	2018	RESULTS: NLRP3 inflammasome activation was dramatically inhibited by curcumin in DSS-stimulated macrophages, as evidenced by decreased IL-1beta secretion, less caspase-1 activation and ASC specks.	Curcumin	69-77	interleukin 1 beta	Mus musculus	135-143
30396035-12	2018	Meanwhile, curcumin significantly decreased the expression of multiple inflammatory cytokines (including mature IL-1beta, IL-6, MCP-1), MPO activity, caspase-1 activity as well as histopathological damage.	Curcumin	11-19	interleukin 1 beta	Mus musculus	112-120
30396035-12	2018	Meanwhile, curcumin significantly decreased the expression of multiple inflammatory cytokines (including mature IL-1beta, IL-6, MCP-1), MPO activity, caspase-1 activity as well as histopathological damage.	Curcumin	11-19	interleukin 6	Mus musculus	122-126
30396035-12	2018	Meanwhile, curcumin significantly decreased the expression of multiple inflammatory cytokines (including mature IL-1beta, IL-6, MCP-1), MPO activity, caspase-1 activity as well as histopathological damage.	Curcumin	11-19	mast cell protease 1	Mus musculus	128-133
30622669-0	2018	Novel Curcumin C66 That Protects Diabetes-Induced Aortic Damage Was Associated with Suppressing JNK2 and Upregulating Nrf2 Expression and Function.	Curcumin	6-14	mitogen-activated protein kinase 9	Mus musculus	96-100
30527253-11	2018	Curcumin may play an anti-oxidative role by reducing circulating MDA concentrations and increasing SOD activity.	Curcumin	0-8	superoxide dismutase 1	Homo sapiens	99-102
30565175-0	2018	Synergistic delivery of 5-fluorouracil and curcumin using human serum albumin-coated iron oxide nanoparticles by folic acid targeting.	Curcumin	43-51	albumin	Homo sapiens	70-77
30268739-0	2018	Intonation of Nrf2 and Hif1-alpha pathway by curcumin prophylaxis: A potential strategy to augment survival signaling under hypoxia.	Curcumin	45-53	NFE2 like bZIP transcription factor 2	Rattus norvegicus	14-18
30268739-8	2018	However, the curcumin supplementation both in-vitro and in-vivo resulted into increased expressions of HO-1 and Nrf2 significantly (p &lt; 0.001), which enabled the cells in balanced expression of SPs with reduced levels of oxidants.	Curcumin	13-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	112-116
30568488-0	2018	Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action.	Curcumin	8-16	tumor protein p53	Homo sapiens	31-34
30568488-11	2018	This review summarizes the effects of curcumin as a regulator of p53 in BC and the key molecular mechanisms of this regulation.	Curcumin	38-46	tumor protein p53	Homo sapiens	65-68
30302613-8	2018	Both CNM and curcumin activated the nuclear factor erythroid 2 related factor 2 (Nrf2) and restored levels of downstream antioxidant enzymes superoxide dismutase and glutathione-S-transferase (GST) in the hippocampus.	Curcumin	13-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	36-79
30302613-8	2018	Both CNM and curcumin activated the nuclear factor erythroid 2 related factor 2 (Nrf2) and restored levels of downstream antioxidant enzymes superoxide dismutase and glutathione-S-transferase (GST) in the hippocampus.	Curcumin	13-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	81-85
30466625-0	2018	Intranasal curcumin regulates chronic asthma in mice by modulating NF-kB activation and MAPK signaling.	Curcumin	11-19	mitogen-activated protein kinase 1	Mus musculus	88-92
30466625-3	2018	STUDY DESIGN/METHOD: Mice were sensitized and exposed to 2% OVA aerosol for 2 times in a week for five consecutive weeks to study effect of intranasal curcumin on various MAPK pathway enzymes involved in chronic asthma and its effect on the activation of nuclear factor kB (NF-kB).	Curcumin	151-159	mitogen-activated protein kinase 1	Mus musculus	171-175
30466625-5	2018	Curcumin treatment had significantly decreased the phosphorylation of JNK, ERK1/2, and p38 and COX-2 expression thereby nuclear factor kappaB (NF-kappaB) activation and expression in lung tissues.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-141
30466625-5	2018	Curcumin treatment had significantly decreased the phosphorylation of JNK, ERK1/2, and p38 and COX-2 expression thereby nuclear factor kappaB (NF-kappaB) activation and expression in lung tissues.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-152
30466625-6	2018	CONCLUSION: These results suggest that intranasal curcumin protects against asthma via action on mitogen-activated protein kinase (MAPK)/NF-kappaB signaling pathways.	Curcumin	50-58	mitogen-activated protein kinase 1	Mus musculus	131-135
30466625-6	2018	CONCLUSION: These results suggest that intranasal curcumin protects against asthma via action on mitogen-activated protein kinase (MAPK)/NF-kappaB signaling pathways.	Curcumin	50-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	137-146
30622669-0	2018	Novel Curcumin C66 That Protects Diabetes-Induced Aortic Damage Was Associated with Suppressing JNK2 and Upregulating Nrf2 Expression and Function.	Curcumin	6-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	118-122
30468499-3	2018	The aim of the present study was to investigate the role of curcumin in regulating autophagy and mammalian target of rapamycin (mTOR) signaling in isoproterenol-induced cardiac hypertrophy and fibrosis in the rat.	Curcumin	60-68	mechanistic target of rapamycin kinase	Homo sapiens	97-126
30268781-0	2018	Curcumin Protects Against Chronic Stress-induced Dysregulation of Neuroplasticity and Depression-like Behaviors via Suppressing IL-1beta Pathway in Rats.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	128-136
29579407-14	2018	Our results indicate that ketamine-induced toxicity in rat thymocytes mainly occurs through the mitochondria-mediated apoptotic pathway and that the PI3K/Akt signaling pathway is involved in the anti-apoptotic effect of curcumin.	Curcumin	220-228	AKT serine/threonine kinase 1	Rattus norvegicus	154-157
30335638-0	2018	Bromophenol curcumin analog BCA-5 exerts an antiangiogenic effect through the HIF-1alpha/VEGF/Akt signaling pathway in human umbilical vein endothelial cells.	Curcumin	12-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88
30335638-0	2018	Bromophenol curcumin analog BCA-5 exerts an antiangiogenic effect through the HIF-1alpha/VEGF/Akt signaling pathway in human umbilical vein endothelial cells.	Curcumin	12-20	vascular endothelial growth factor A	Homo sapiens	89-93
30172244-8	2018	In vivo experiments indicated that curcumin loaded hydrogels significantly accelerated wound healing rate with higher granulation tissue thickness and collagen disposition and upregulated vascular endothelial growth factor (VEGF) in a full-thickness skin defect model.	Curcumin	35-43	vascular endothelial growth factor A	Homo sapiens	188-222
30172244-8	2018	In vivo experiments indicated that curcumin loaded hydrogels significantly accelerated wound healing rate with higher granulation tissue thickness and collagen disposition and upregulated vascular endothelial growth factor (VEGF) in a full-thickness skin defect model.	Curcumin	35-43	vascular endothelial growth factor A	Homo sapiens	224-228
30155758-9	2018	Curcumin has similar effects with 3-MA, in which curcumin inhibited NF-kappaB by preventing the translocation of NF-kappaB p65.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	68-77
30155758-9	2018	Curcumin has similar effects with 3-MA, in which curcumin inhibited NF-kappaB by preventing the translocation of NF-kappaB p65.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-122
30155758-9	2018	Curcumin has similar effects with 3-MA, in which curcumin inhibited NF-kappaB by preventing the translocation of NF-kappaB p65.	Curcumin	49-57	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	68-77
30155758-9	2018	Curcumin has similar effects with 3-MA, in which curcumin inhibited NF-kappaB by preventing the translocation of NF-kappaB p65.	Curcumin	49-57	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-122
30499350-8	2018	The main activities of GAMCLCL and curcumin included inhibition of HepG2 cell proliferation, inhibition of tumor growth, reduction of tumor microvascular density, down-regulation of the expression of VEGF protein, and up-regulation of the expression of Caspases3 protein in H22 tumor tissues.	Curcumin	35-43	vascular endothelial growth factor A	Homo sapiens	200-204
30344661-0	2018	Dynamics study on the role of curcumin on TGF-beta1 expression and pathological changes in acute paraquat poisoned rats.	Curcumin	30-38	transforming growth factor, beta 1	Rattus norvegicus	42-51
30344661-15	2018	The level of ROS, ALT, AST, MDA of the rats in PQ + curcumin group reached the highest value on the 3rd day, while the level of SOD reached the lowest value; furthermore, the level of ROS, ALT, AST, MDA was lower than that in PQ group, while the level of SOD was higher than that of the PQ group.	Curcumin	52-60	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	194-197
30344661-16	2018	The results showed that curcumin can effectively inhibit the expression of TGF-beta1, prevent PQ-induced liver cell oxidative damage and play an important role in the protection of liver function.	Curcumin	24-32	transforming growth factor, beta 1	Rattus norvegicus	75-84
30466988-0	2018	Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells.	Curcumin	0-8	prepronociceptin	Homo sapiens	52-62
30534177-0	2018	Curcumin Downregulates Human GM3 Synthase (hST3Gal V) Gene Expression with Autophagy Induction in Human Colon Carcinoma HCT116 Cells.	Curcumin	0-8	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	29-41
30534177-0	2018	Curcumin Downregulates Human GM3 Synthase (hST3Gal V) Gene Expression with Autophagy Induction in Human Colon Carcinoma HCT116 Cells.	Curcumin	0-8	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	43-52
30534177-2	2018	In this study, on the contrary to this finding, we demonstrated that curcumin downregulated the gene expression of human GM3 synthase (hST3Gal V) catalyzing ganglioside GM3 synthesis with autophagy induction in human colon carcinoma HCT116 cells.	Curcumin	69-77	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	121-133
30534177-2	2018	In this study, on the contrary to this finding, we demonstrated that curcumin downregulated the gene expression of human GM3 synthase (hST3Gal V) catalyzing ganglioside GM3 synthesis with autophagy induction in human colon carcinoma HCT116 cells.	Curcumin	69-77	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	135-144
30534177-3	2018	To clarify the mechanism leading to the downregulation of hST3Gal V gene expression in curcumin-treated HCT116 cells, we analyzed the curcumin-inducible promoter of the hST3Gal V gene by luciferase reporter assays.	Curcumin	87-95	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	58-67
30534177-3	2018	To clarify the mechanism leading to the downregulation of hST3Gal V gene expression in curcumin-treated HCT116 cells, we analyzed the curcumin-inducible promoter of the hST3Gal V gene by luciferase reporter assays.	Curcumin	87-95	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	169-178
30534177-3	2018	To clarify the mechanism leading to the downregulation of hST3Gal V gene expression in curcumin-treated HCT116 cells, we analyzed the curcumin-inducible promoter of the hST3Gal V gene by luciferase reporter assays.	Curcumin	134-142	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	58-67
30534177-3	2018	To clarify the mechanism leading to the downregulation of hST3Gal V gene expression in curcumin-treated HCT116 cells, we analyzed the curcumin-inducible promoter of the hST3Gal V gene by luciferase reporter assays.	Curcumin	134-142	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	169-178
30534177-4	2018	Promoter deletion analysis demonstrated that the -177 to -83 region, which includes putative binding sites for transcription factors NFY, CREB/ATF, SP1, EGR3, and MZF1, acts as the curcumin-responsive promoter of the hST3Gal V gene.	Curcumin	181-189	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	217-226
30534177-5	2018	Site-directed mutagenesis and chromatin immunoprecipitation analysis demonstrated that the CREB/ATF binding site at -143 is pivotal for curcumin-induced downregulation of hST3Gal V gene in HCT116 cells.	Curcumin	136-144	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	171-180
30335638-0	2018	Bromophenol curcumin analog BCA-5 exerts an antiangiogenic effect through the HIF-1alpha/VEGF/Akt signaling pathway in human umbilical vein endothelial cells.	Curcumin	12-20	AKT serine/threonine kinase 1	Homo sapiens	94-97
30155758-10	2018	Curcumin also inhibited the phosphorylation of p-PI3K, p-AKT, and p-IKK, which leads to down-regulation of NF-kappaB.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	57-60
30155758-10	2018	Curcumin also inhibited the phosphorylation of p-PI3K, p-AKT, and p-IKK, which leads to down-regulation of NF-kappaB.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	107-116
30155758-11	2018	Curcumin reduced autophagy via PI3K/AKT/IKK/NF-kappaB, thereby reducing BV2 cellular inflammation induced by gp120.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	36-39
30155758-11	2018	Curcumin reduced autophagy via PI3K/AKT/IKK/NF-kappaB, thereby reducing BV2 cellular inflammation induced by gp120.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	44-53
30137697-0	2018	Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice.	Curcumin	10-18	jagged 1	Mus musculus	167-174
30137697-0	2018	Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice.	Curcumin	10-18	jagged 2	Mus musculus	175-182
30226563-0	2018	Downregulation of glucose-regulated protein 78 enhances the cytotoxic effects of curcumin on human nasopharyngeal carcinoma cells.	Curcumin	81-89	heat shock protein family A (Hsp70) member 5	Homo sapiens	18-46
30226563-9	2018	siRNA-induced knockdown of GRP78 may be able to strengthen the toxic effects of curcumin through mediating the AKT signaling pathway.	Curcumin	80-88	heat shock protein family A (Hsp70) member 5	Homo sapiens	27-32
29607689-10	2018	Conclusion: Our study indicates that both antioxidants, curcumin and resveratrol, are useful in reducing neurodegeneration in selective areas of cornus ammonis 1 (CA1), CA3, dentate gyrus (DG) and the cortex of mice brain and in recuperating the loss of memory and learning caused due to fluoride exposure.	Curcumin	56-64	carbonic anhydrase 3	Mus musculus	169-172
30226563-9	2018	siRNA-induced knockdown of GRP78 may be able to strengthen the toxic effects of curcumin through mediating the AKT signaling pathway.	Curcumin	80-88	AKT serine/threonine kinase 1	Homo sapiens	111-114
30226563-10	2018	These findings indicated that downregulation of GRP78 promoted the therapeutic effects of curcumin on NPC cells.	Curcumin	90-98	heat shock protein family A (Hsp70) member 5	Homo sapiens	48-53
29923222-7	2018	It has been showed that curcumin exerts its therapeutic effects on HBV patients via targeting a variety of cellular and molecular pathways such as Wnt/beta-catenin, Ap1, STAT3, MAPK, and NF-kappaB signaling.	Curcumin	24-32	signal transducer and activator of transcription 3	Homo sapiens	170-175
29741772-0	2018	Curcumin alleviates ischemia reperfusion-induced late kidney fibrosis through the APPL1/Akt signaling pathway.	Curcumin	0-8	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	Mus musculus	82-87
29741772-0	2018	Curcumin alleviates ischemia reperfusion-induced late kidney fibrosis through the APPL1/Akt signaling pathway.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	88-91
30292723-6	2018	Curcumin activated AMPK and JNK1, which phosphorylated Bcl-2 and Bim and subsequently disrupted their interactions with Beclin1, thereby promoting autophagy and alleviating apoptosis respectively.	Curcumin	0-8	B cell leukemia/lymphoma 2	Mus musculus	55-60
29741772-4	2018	Here, we found that APPL1, an important intracellular binding partner for AdipoR, was involved in the pathogenesis of acute injury or fibrosis and was significantly upregulated by curcumin in a mouse model of ischemia reperfusion-induced late kidney fibrosis.	Curcumin	180-188	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	Mus musculus	20-25
29741772-6	2018	Our in vitro experiment demonstrated that curcumin alleviates ischemia reperfusion-induced late kidney fibrosis via the APPL1/Akt pathway.	Curcumin	42-50	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	Mus musculus	120-125
29741772-6	2018	Our in vitro experiment demonstrated that curcumin alleviates ischemia reperfusion-induced late kidney fibrosis via the APPL1/Akt pathway.	Curcumin	42-50	thymoma viral proto-oncogene 1	Mus musculus	126-129
29957091-6	2018	Curcumin interacts with receptors, growth and transcription factors, cytokines, enzymes, and genes leading to inhibitory effects on cyclooxygenase-1, tumor necrosis factor-alpha, interferon-gamma, inducible nitric oxide synthase, transcriptional nuclear factor kappa B, and many other molecules associated with inflammatory processes.	Curcumin	0-8	prostaglandin-endoperoxide synthase 1	Homo sapiens	132-177
29957091-6	2018	Curcumin interacts with receptors, growth and transcription factors, cytokines, enzymes, and genes leading to inhibitory effects on cyclooxygenase-1, tumor necrosis factor-alpha, interferon-gamma, inducible nitric oxide synthase, transcriptional nuclear factor kappa B, and many other molecules associated with inflammatory processes.	Curcumin	0-8	interferon gamma	Homo sapiens	179-228
30405819-6	2018	It was determined that curcumin decreased the tumor weight and size, downregulated the expression of Notch and HIF-1 mRNA and suppressed the VEGF and NF-kappaB expression.	Curcumin	23-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	150-159
29917258-0	2018	Curcumin ameliorates cisplatin-induced cystopathy via activating NRF2 pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	65-69
29917258-10	2018	Curcumin also activated NRF2, and elevated the expression of HO-1, but curcumin could not rescue cisplatin-induced apoptosis in the cell lines with knockdown of NRF2.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	24-28
29917258-12	2018	This may be attributed to curcumin"s broad biological functions, particularly antioxidant effect, and to its ability to activate the NRF2 protein.	Curcumin	26-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	133-137
30333889-7	2018	Cetuximab and curcumin combination induced apoptosis and dramatically increased caspase-3 and caspase-9 activities compared with singular treatment.	Curcumin	14-22	caspase 3	Homo sapiens	80-89
30333889-9	2018	The results demonstrated that co-treatment with cetuximab and curcumin exerts synergistic oral anticancer effects on CAR cells through the suppression of the EGFR signaling by regulation of the MAPK pathway.	Curcumin	62-70	epidermal growth factor receptor	Homo sapiens	158-162
29959624-0	2018	Combination Therapy with Curcumin Alone Plus Piperine Ameliorates Ovalbumin-Induced Chronic Asthma in Mice.	Curcumin	25-33	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	66-75
30315965-4	2018	A growing body of evidence indicates that curcumin, a natural bioactive compound of turmeric root, significantly targets both HIF-1 subunits, but is more potent against HIF-1alpha.	Curcumin	42-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-131
30315965-4	2018	A growing body of evidence indicates that curcumin, a natural bioactive compound of turmeric root, significantly targets both HIF-1 subunits, but is more potent against HIF-1alpha.	Curcumin	42-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	169-179
30315965-5	2018	In this review, we have summarized the knowledge about the pharmacological effects of curcumin on HIF-1 and the related molecular mechanisms that may be effective candidates for the development of multi-targeted therapy for several human diseases.	Curcumin	86-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-103
30416653-0	2018	Therapeutic ultrasound potentiates the anti-nociceptive and anti-inflammatory effects of curcumin to postoperative pain via Sirt1/NF-kappaB signaling pathway.	Curcumin	89-97	sirtuin 1	Rattus norvegicus	124-129
29961171-0	2018	Curcumin Attenuates Airway Inflammation and Airway Remolding by Inhibiting NF-kappaB Signaling and COX-2 in Cigarette Smoke-Induced COPD Mice.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-84
29961171-6	2018	Further investigation demonstrated an underlying molecular mechanism for the therapeutic effects of curcumin may rely on the inhibition of the degradation of IkappaBalpha and COX-2 expression in curcumin+LC-treated COPD mice and LPS-stimulated BEAS-2B cells.	Curcumin	100-108	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	158-170
30248460-0	2018	Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome inhibition.	Curcumin	0-8	microRNA 200a	Rattus norvegicus	86-94
30248460-0	2018	Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome inhibition.	Curcumin	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	110-115
30248460-9	2018	Curcumin, as well as allopurinol, notably up-regulated miR-200a expression, accordingly, down-regulated TXNIP and inhibited NLRP3 inflammasome activation in fructose-fed rat livers and fructose-exposed BRL-3 A and HepG2 cells.	Curcumin	0-8	microRNA 200a	Rattus norvegicus	55-63
30248460-9	2018	Curcumin, as well as allopurinol, notably up-regulated miR-200a expression, accordingly, down-regulated TXNIP and inhibited NLRP3 inflammasome activation in fructose-fed rat livers and fructose-exposed BRL-3 A and HepG2 cells.	Curcumin	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	124-129
30248460-10	2018	Taken together, this study firstly identified miR-200a as a biomarker of fructose-induced hepatic inflammation, and revealed the hepatoprotection of curcumin and allopurinol via up-regulating miR-200a-mediated TXNIP/NLRP3 inflammasome pathway.	Curcumin	149-157	microRNA 200a	Rattus norvegicus	192-200
30248460-10	2018	Taken together, this study firstly identified miR-200a as a biomarker of fructose-induced hepatic inflammation, and revealed the hepatoprotection of curcumin and allopurinol via up-regulating miR-200a-mediated TXNIP/NLRP3 inflammasome pathway.	Curcumin	149-157	NLR family, pyrin domain containing 3	Rattus norvegicus	216-221
30741618-6	2018	The result displayed that Curcumin pretreatment can significantly increase the expression of p-JAK2 and p-STAT3 and reduce the expression of Cr, BUN, IL-8, TNF-alpha, IL-6, and p-p65.	Curcumin	26-34	tumor necrosis factor	Rattus norvegicus	156-165
30741618-6	2018	The result displayed that Curcumin pretreatment can significantly increase the expression of p-JAK2 and p-STAT3 and reduce the expression of Cr, BUN, IL-8, TNF-alpha, IL-6, and p-p65.	Curcumin	26-34	interleukin 6	Rattus norvegicus	167-171
30741618-6	2018	The result displayed that Curcumin pretreatment can significantly increase the expression of p-JAK2 and p-STAT3 and reduce the expression of Cr, BUN, IL-8, TNF-alpha, IL-6, and p-p65.	Curcumin	26-34	synaptotagmin 1	Rattus norvegicus	179-182
30350003-0	2018	Curcumin-loaded chitosan-bovine serum albumin nanoparticles potentially enhanced Abeta 42 phagocytosis and modulated macrophage polarization in Alzheimer"s disease.	Curcumin	0-8	albumin	Homo sapiens	32-45
30386242-0	2018	Curcumin"s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-kappaB Pathway.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-154
30243647-13	2018	SIGNIFICANCE: According to these results, it may be suggested that curcumin exerts anticonvulsive effects by increasing the serotonin levels in the brain that influence receptors, including 5-HT1A, 5-HT2C, and 5-HT4 and likely through the reduction of 5-HT7 gene expression.	Curcumin	67-75	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	190-196
30333956-5	2018	Treatment of HNSCC cell lines with curcumin, a natural compound isolated from rhizomes of the plant Curcuma longa, or transfection of small interfering RNA of Skp2, causes down-regulation of Skp2 with concomitant accumulation of p21 and p27 in HPV+, HPV- cells.	Curcumin	35-43	cyclin dependent kinase inhibitor 1A	Homo sapiens	229-232
29644554-4	2018	The results showed that palmitate upregulated the mRNA expression and protein release of IL-6 and TNF-alpha cytokines in C2C12 cells, while pretreatment with curcumin was able to attenuate the effect of palmitate on inflammatory cytokines.	Curcumin	158-166	interleukin 6	Mus musculus	89-93
29644554-4	2018	The results showed that palmitate upregulated the mRNA expression and protein release of IL-6 and TNF-alpha cytokines in C2C12 cells, while pretreatment with curcumin was able to attenuate the effect of palmitate on inflammatory cytokines.	Curcumin	158-166	tumor necrosis factor	Mus musculus	98-107
29961171-6	2018	Further investigation demonstrated an underlying molecular mechanism for the therapeutic effects of curcumin may rely on the inhibition of the degradation of IkappaBalpha and COX-2 expression in curcumin+LC-treated COPD mice and LPS-stimulated BEAS-2B cells.	Curcumin	195-203	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	158-170
29961171-7	2018	Overall, curcumin alleviates the airway inflammation and airway remolding, which is closely related to inhibit the BEAS-2B cells proliferation and suppress the activation of NF-kappaB and COX-2 expression.	Curcumin	9-17	nuclear factor kappa B subunit 1	Homo sapiens	174-183
29961171-7	2018	Overall, curcumin alleviates the airway inflammation and airway remolding, which is closely related to inhibit the BEAS-2B cells proliferation and suppress the activation of NF-kappaB and COX-2 expression.	Curcumin	9-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-193
31516880-5	2018	In this study, we evaluated the effects of curcumin treatment on the regulation of IL-4 and IL-13, DUOX1 &amp; 2 genes as well as the pathological changes developed by this treatment.	Curcumin	43-51	interleukin 13	Rattus norvegicus	92-97
30136034-5	2018	Moreover, the treatment of curcumin for 24 h significantly suppressed cell migration, together with the downregulation of matrix metalloproteinase-2 (MMP-2) and upregulation of tissue inhibitor of metalloproteinases-1 (TIMP-1).	Curcumin	27-35	TIMP metallopeptidase inhibitor 1	Homo sapiens	177-217
30136034-5	2018	Moreover, the treatment of curcumin for 24 h significantly suppressed cell migration, together with the downregulation of matrix metalloproteinase-2 (MMP-2) and upregulation of tissue inhibitor of metalloproteinases-1 (TIMP-1).	Curcumin	27-35	TIMP metallopeptidase inhibitor 1	Homo sapiens	219-225
31516880-5	2018	In this study, we evaluated the effects of curcumin treatment on the regulation of IL-4 and IL-13, DUOX1 &amp; 2 genes as well as the pathological changes developed by this treatment.	Curcumin	43-51	dual oxidase 1	Rattus norvegicus	99-104
31516880-13	2018	Treatment with curcumin downregulated the expression of IL-4, IL4Ra1, DUOX1 &amp; 2.	Curcumin	15-23	dual oxidase 1	Rattus norvegicus	70-75
29860383-1	2018	Curcumin has been reported to inhibit inflammation, tumor growth, angiogenesis and metastasis by decreasing cell growth and by inducing apoptosis mainly through the inhibition of nuclear factor kappa-B (NFkappaB), a master regulator of inflammation.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	179-201
29974318-2	2018	In the present study, we investigated the preventive effects of curcumin against AFB1-induced apoptosis through the molecular regulation of p53, caspase-3, Bax, caspase-9, Bcl-2 and cytochrome-C associated with mitochondrial pathway.	Curcumin	64-72	tumor protein p53	Homo sapiens	140-143
29974318-2	2018	In the present study, we investigated the preventive effects of curcumin against AFB1-induced apoptosis through the molecular regulation of p53, caspase-3, Bax, caspase-9, Bcl-2 and cytochrome-C associated with mitochondrial pathway.	Curcumin	64-72	BCL2 associated X, apoptosis regulator	Homo sapiens	156-159
30066930-6	2018	The results indicated that curcumin and paclitaxel induced apoptosis and necrosis, which was demonstrated through multiple methods, including assays of caspase-3/7 activity, Annexin V, poly(ADP-ribose) polymerase-1 activation and protein expression of caspase-3, nuclear factor (NF)-kappaB transcription factor and proliferating cell nuclear antigen.	Curcumin	27-35	caspase 3	Homo sapiens	152-161
30066930-6	2018	The results indicated that curcumin and paclitaxel induced apoptosis and necrosis, which was demonstrated through multiple methods, including assays of caspase-3/7 activity, Annexin V, poly(ADP-ribose) polymerase-1 activation and protein expression of caspase-3, nuclear factor (NF)-kappaB transcription factor and proliferating cell nuclear antigen.	Curcumin	27-35	poly(ADP-ribose) polymerase 1	Homo sapiens	185-214
30066930-6	2018	The results indicated that curcumin and paclitaxel induced apoptosis and necrosis, which was demonstrated through multiple methods, including assays of caspase-3/7 activity, Annexin V, poly(ADP-ribose) polymerase-1 activation and protein expression of caspase-3, nuclear factor (NF)-kappaB transcription factor and proliferating cell nuclear antigen.	Curcumin	27-35	caspase 3	Homo sapiens	252-261
30377131-0	2018	[Curcumin suppresses cigarette smoke extract-induced oxidative stress through PPARgamma/ NF-kappaB pathway in human bronchial epithelial cells in vitro].	Curcumin	1-9	peroxisome proliferator activated receptor gamma	Homo sapiens	78-87
30377131-0	2018	[Curcumin suppresses cigarette smoke extract-induced oxidative stress through PPARgamma/ NF-kappaB pathway in human bronchial epithelial cells in vitro].	Curcumin	1-9	nuclear factor kappa B subunit 1	Homo sapiens	89-98
30377131-7	2018	The effects of CSE were significantly suppressed by curcumin, but transfection of the cells with shRNA-PPARgamma obviously abrogated the suppressive effects of curcumin.	Curcumin	160-168	peroxisome proliferator activated receptor gamma	Homo sapiens	103-112
30377131-8	2018	CONCLUSIONS: Curcumin suppresses CSE-induced oxidative stress and inflammation via the PPARgamma/NF-kappaB signaling pathway in 16HBE cells, suggesting the potential of curcumin in the treatment of chronic obstructive pulmonary disease.	Curcumin	13-21	peroxisome proliferator activated receptor gamma	Homo sapiens	87-96
30377131-8	2018	CONCLUSIONS: Curcumin suppresses CSE-induced oxidative stress and inflammation via the PPARgamma/NF-kappaB signaling pathway in 16HBE cells, suggesting the potential of curcumin in the treatment of chronic obstructive pulmonary disease.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	97-106
30377131-8	2018	CONCLUSIONS: Curcumin suppresses CSE-induced oxidative stress and inflammation via the PPARgamma/NF-kappaB signaling pathway in 16HBE cells, suggesting the potential of curcumin in the treatment of chronic obstructive pulmonary disease.	Curcumin	169-177	peroxisome proliferator activated receptor gamma	Homo sapiens	87-96
30377131-8	2018	CONCLUSIONS: Curcumin suppresses CSE-induced oxidative stress and inflammation via the PPARgamma/NF-kappaB signaling pathway in 16HBE cells, suggesting the potential of curcumin in the treatment of chronic obstructive pulmonary disease.	Curcumin	169-177	nuclear factor kappa B subunit 1	Homo sapiens	97-106
30257470-5	2018	Finally, we discuss about the crosstalk between these three critical pathways as well as how the anti-inflammatory antioxidant phytochemicals like sulforaphane (SFN) and curcumin (CUR), which can also target AR, can be ideal candidates in the chemoprevention of PCa.	Curcumin	170-178	androgen receptor	Homo sapiens	208-210
29737515-8	2018	Our data showed that phytosomal curcumin and its combination with 5-FU inhibited cell growth and invasive behavior of CRC cells through modulation of Wnt-pathway and E-cadherin.	Curcumin	32-40	cadherin 1	Mus musculus	166-176
29737515-10	2018	Also, curcumin suppressed the colonic inflammation and notably recovered the increased levels of MDA, decreased thiol level and reduced activity of CAT.	Curcumin	6-14	catalase	Mus musculus	148-151
30250013-3	2018	Curcumin modulates relevant molecular target pathways to improve glucose and lipid metabolism, suppress inflammation, stimulate antioxidant enzymes, facilitate insulin signalling and reduce gut permeability.	Curcumin	0-8	insulin	Homo sapiens	160-167
30250013-4	2018	Curcumin also inhibits Abeta and tau accumulation in animal models and enhances mitochondria and synaptic function.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	23-28
29860383-1	2018	Curcumin has been reported to inhibit inflammation, tumor growth, angiogenesis and metastasis by decreasing cell growth and by inducing apoptosis mainly through the inhibition of nuclear factor kappa-B (NFkappaB), a master regulator of inflammation.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	203-211
30327711-12	2018	Treatment of cultured human artery endothelial cells with curcumin induced the HO-1 expression through the activation of nuclear factor-E2-related factor 2 (Nrf2) and an antioxidant responsive element via the p38 MAPK signalling pathway.	Curcumin	58-66	NFE2 like bZIP transcription factor 2	Homo sapiens	157-161
30327711-12	2018	Treatment of cultured human artery endothelial cells with curcumin induced the HO-1 expression through the activation of nuclear factor-E2-related factor 2 (Nrf2) and an antioxidant responsive element via the p38 MAPK signalling pathway.	Curcumin	58-66	mitogen-activated protein kinase 14	Homo sapiens	209-212
29486375-1	2018	PURPOSE: In this research, aspartic acid functionalized PEGylated mesoporous silica nanoparticlesgraphene oxide nanohybrid (As-PEGylated-MSN@GO) prepared as a pH-responsive drug carrier for the curcumin delivery.	Curcumin	194-202	moesin	Homo sapiens	137-140
30956867-0	2019	Chondroprotective effect of curcumin and lecithin complex in human chondrocytes stimulated by IL-1beta via an anti-inflammatory mechanism.	Curcumin	28-36	interleukin 1 beta	Homo sapiens	94-102
30056019-10	2018	Curcumin treatment also resulted in a decrease in anti-apoptotic proteins, p-Akt, Akt, Bcl-2 and p-Bad, and increase in pro-apoptotic proteins Bad and c-PARP levels in the control cells but not in the HSP27-KD cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	77-80
30056019-10	2018	Curcumin treatment also resulted in a decrease in anti-apoptotic proteins, p-Akt, Akt, Bcl-2 and p-Bad, and increase in pro-apoptotic proteins Bad and c-PARP levels in the control cells but not in the HSP27-KD cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	82-85
30056019-10	2018	Curcumin treatment also resulted in a decrease in anti-apoptotic proteins, p-Akt, Akt, Bcl-2 and p-Bad, and increase in pro-apoptotic proteins Bad and c-PARP levels in the control cells but not in the HSP27-KD cells.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	87-92
30218018-6	2018	We validated genes belonging to these pathways, such as HSPA5, SEC61B, G6PD, HMOX1 and PDE3B to be cooperatively modulated by the OPCs-curcumin combination.	Curcumin	135-143	heat shock protein family A (Hsp70) member 5	Homo sapiens	56-61
30209353-8	2018	Both curcumin (P = 0.01) and curcumin + fishoil (P = 0.03) treatments significantly lowered postprandial insulin (AUC) by 26% in comparison with placebo.	Curcumin	5-13	insulin	Homo sapiens	105-112
30209353-8	2018	Both curcumin (P = 0.01) and curcumin + fishoil (P = 0.03) treatments significantly lowered postprandial insulin (AUC) by 26% in comparison with placebo.	Curcumin	29-37	insulin	Homo sapiens	105-112
30209353-9	2018	Curcumin, but not fish oil, reduces postprandial glycaemic response and insulin demand for glucose control.	Curcumin	0-8	insulin	Homo sapiens	72-79
30010822-4	2018	Taxifolin and silymarin were "high binders" for ERalpha ligand binding; quercetin and curcumin were "high activators" for ERalpha transactivation.	Curcumin	86-94	estrogen receptor 1	Homo sapiens	122-129
30130550-11	2018	Furthermore, mRNA level of TNF-alpha was considerably reduced in animals undergone curcumin-loaded NPs treatment.	Curcumin	83-91	tumor necrosis factor	Mus musculus	27-36
30130550-12	2018	Overall, the results of this study suggest that downregulation of TNF-alpha and consequent upregulation of klotho and EPO might contribute to the neuroprotective effect of curcumin-loaded NPs in experimental model of epilepsy.	Curcumin	172-180	tumor necrosis factor	Mus musculus	66-75
30036770-5	2018	The Western blotting showed that Curcumin inhibited the function of KCs via down-regulating the nuclear factor kappab (NF-kappab) signaling pathway by activating peroxisome proliferator-activated receptor gamma (PPARgamma) and flow cytometry revealed that Curcumin suppressed pro-inflammatory phenotype (M1) of KCs while promoting its anti-inflammatory phenotype (M2) polarization.	Curcumin	33-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	119-128
30036770-5	2018	The Western blotting showed that Curcumin inhibited the function of KCs via down-regulating the nuclear factor kappab (NF-kappab) signaling pathway by activating peroxisome proliferator-activated receptor gamma (PPARgamma) and flow cytometry revealed that Curcumin suppressed pro-inflammatory phenotype (M1) of KCs while promoting its anti-inflammatory phenotype (M2) polarization.	Curcumin	256-264	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	119-128
30036770-6	2018	These results showed that Curcumin may exert positive effects on I/R injury after OLT through activating PPARgamma by inhibiting the activation of NF-kappab pathway and remodeling the polarization of KCs.	Curcumin	26-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	147-156
29860219-0	2018	Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	59-63
29860219-0	2018	Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice.	Curcumin	0-8	nuclear receptor subfamily 1, group H, member 4	Mus musculus	64-67
29860219-0	2018	Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice.	Curcumin	0-8	nuclear receptor subfamily 1, group H, member 3	Mus musculus	68-71
29860219-7	2018	In addition, LXRalpha antagonist GGPP pretreatment weakened the curcumin effects on CYP3A, CYP7A and SREBP-1c.	Curcumin	64-72	nuclear receptor subfamily 1, group H, member 3	Mus musculus	13-21
29860219-8	2018	CONCLUSIONS: These findings indicate that the Nrf2/FXR/LXRalpha pathway might synergistically regulate both endogenous and exogenous metabolism in NAFLD mice and LXRalpha may be a novel therapeutic target of curcumin for the prevention and treatment of NAFLD.	Curcumin	208-216	nuclear factor, erythroid derived 2, like 2	Mus musculus	46-50
29860219-8	2018	CONCLUSIONS: These findings indicate that the Nrf2/FXR/LXRalpha pathway might synergistically regulate both endogenous and exogenous metabolism in NAFLD mice and LXRalpha may be a novel therapeutic target of curcumin for the prevention and treatment of NAFLD.	Curcumin	208-216	nuclear receptor subfamily 1, group H, member 4	Mus musculus	51-54
29860219-8	2018	CONCLUSIONS: These findings indicate that the Nrf2/FXR/LXRalpha pathway might synergistically regulate both endogenous and exogenous metabolism in NAFLD mice and LXRalpha may be a novel therapeutic target of curcumin for the prevention and treatment of NAFLD.	Curcumin	208-216	nuclear receptor subfamily 1, group H, member 3	Mus musculus	55-63
29860219-8	2018	CONCLUSIONS: These findings indicate that the Nrf2/FXR/LXRalpha pathway might synergistically regulate both endogenous and exogenous metabolism in NAFLD mice and LXRalpha may be a novel therapeutic target of curcumin for the prevention and treatment of NAFLD.	Curcumin	208-216	nuclear receptor subfamily 1, group H, member 3	Mus musculus	162-170
30043720-5	2018	In response to dietary curcumin supplementation, concentrations of inflammatory cytokines and activities of AST and ALT in the serum and MDA, PC and 8-OHDG in the liver were lower (P&lt;0 05), and the hepatic glutathione redox cycle in the liver was improved (P&lt;0 05) in the IC group than in the IUGR group.	Curcumin	23-31	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	108-111
30043720-8	2018	Curcumin appeared to be beneficial in preventing IUGR-induced inflammation, oxidative damage and injury by activating the expression of the NF-kappaB, JAK/STAT and Nfe2l2/ARE pathways in the liver.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	164-170
29753013-0	2018	Transferrin-anchored poly(lactide) based micelles to improve anticancer activity of curcumin in hepatic and cervical cancer cell monolayers and 3D spheroids.	Curcumin	84-92	transferrin	Homo sapiens	0-11
29753013-8	2018	The curcumin-mediated cytotoxicity increased significantly following Tf-PPC treatment in both the tested cell lines.	Curcumin	4-12	transferrin	Homo sapiens	69-71
30181701-3	2018	In this study, we investigated whether curcumin, which acts on TRPV1 receptors, affects histamine-induced itching in mice, using behavioral tests and electrophysiological approaches.	Curcumin	39-47	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	63-68
29911313-0	2018	Curcumin prevents the bile reflux-induced NF-kappaB-related mRNA oncogenic phenotype, in human hypopharyngeal cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	42-51
29911313-3	2018	We hypothesize that curcumin, a dietary inhibitor of NF-kappaB, may effectively inhibit the acidic bile-induced cancer-related mRNA phenotype, in treated human hypopharyngeal primary cells (HHPC), supporting its potential preventive use in vivo.	Curcumin	20-28	nuclear factor kappa B subunit 1	Homo sapiens	53-62
29911313-6	2018	Curcumin effectively reduced bile-induced bcl-2 overexpression at both acidic and neutral pH.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	42-47
29911313-7	2018	Our novel findings suggest that, similar to pharmacologic NF-kappaB inhibitor, BAY 11-7082, curcumin can suppress acidic bile-induced oncogenic mRNA phenotype in hypopharyngeal cells, encouraging its future in vivo pre-clinical and clinical explorations in prevention of bile reflux-related pre-neoplastic events mediated by NF-kappaB.	Curcumin	92-100	nuclear factor kappa B subunit 1	Homo sapiens	325-334
29860655-8	2018	Amifostine, curcumin, and melatonin reduced the increases in serum urea and serum creatinine levels following cisplatin administration and reduced the levels of TNS, HPS, NF-kappaB/p65, 8-OHdG, and caspase-3 expressions (p &lt; 0.05).	Curcumin	12-20	caspase 3	Homo sapiens	198-207
29849119-5	2018	Combined PP242 and curcumin treatment induced Bax activation and decreased expression of Mcl-1 and Bcl-2.	Curcumin	19-27	BCL2 associated X, apoptosis regulator	Homo sapiens	46-49
29849119-5	2018	Combined PP242 and curcumin treatment induced Bax activation and decreased expression of Mcl-1 and Bcl-2.	Curcumin	19-27	BCL2 apoptosis regulator	Homo sapiens	99-104
29849119-6	2018	Furthermore, co-treatment with PP242 and curcumin-induced the downregulation of the Rictor (an mTORC2 complex protein) and Akt protein levels, and ectopic overexpression of Rictor or Akt inhibited PP242 plus curcumin induced cell death.	Curcumin	41-49	AKT serine/threonine kinase 1	Homo sapiens	123-126
29849119-6	2018	Furthermore, co-treatment with PP242 and curcumin-induced the downregulation of the Rictor (an mTORC2 complex protein) and Akt protein levels, and ectopic overexpression of Rictor or Akt inhibited PP242 plus curcumin induced cell death.	Curcumin	41-49	AKT serine/threonine kinase 1	Homo sapiens	183-186
29157028-0	2018	Enhanced selective cellular uptake and cytotoxicity of epidermal growth factor-conjugated liposomes containing curcumin on EGFR-overexpressed pancreatic cancer cells.	Curcumin	111-119	epidermal growth factor receptor	Homo sapiens	123-127
29157028-6	2018	It is also shown that the cellular uptake of curcumin on BxPC-3, which is essential for the cytotoxicity, is associated with EGFR-mediated mechanism of action.	Curcumin	45-53	epidermal growth factor receptor	Homo sapiens	125-129
29157028-7	2018	In summary, our results have showed that targeting EGFR with EGF-conjugated curcumin liposomes enhanced the antitumor activity of curcumin against human pancreatic cancer cells.	Curcumin	76-84	epidermal growth factor receptor	Homo sapiens	51-55
29157028-7	2018	In summary, our results have showed that targeting EGFR with EGF-conjugated curcumin liposomes enhanced the antitumor activity of curcumin against human pancreatic cancer cells.	Curcumin	130-138	epidermal growth factor receptor	Homo sapiens	51-55
29998409-4	2018	Our aim was to determine whether HAT inhibitors such as anacardic acid, garcinol, and curcumin from natural plants reduce severity of L-DOPA-induced dyskinesia using a unilaterally 6-hydroxydopamine (6-OHDA)-lesioned PD mouse model.	Curcumin	86-94	histocompatibility 49	Mus musculus	33-36
29998409-5	2018	Anacardic acid 2 mg/kg, garcinol 5 mg/kg, or curcumin 100 mg/kg co-treatment with L-DOPA significantly reduced the axial, limb, and orofacial (ALO) score indicating less dyskinesia with administration of HAT inhibitors in 6-OHDA-lesioned mice.	Curcumin	45-53	histocompatibility 49	Mus musculus	204-207
30018000-8	2018	Curcumin treatment reduced the production of reactive oxygen species (ROS) (which were notably produced by macrophages), lipid peroxidation and increased expression of transcription factor Nrf2.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	189-193
29849119-6	2018	Furthermore, co-treatment with PP242 and curcumin-induced the downregulation of the Rictor (an mTORC2 complex protein) and Akt protein levels, and ectopic overexpression of Rictor or Akt inhibited PP242 plus curcumin induced cell death.	Curcumin	208-216	AKT serine/threonine kinase 1	Homo sapiens	183-186
29849119-11	2018	Altogether, our results reveal that combined PP242 and curcumin treatment could induce autophagy-mediated cell death by reducing the expression of Rictor and Akt in renal carcinoma cells.	Curcumin	55-63	AKT serine/threonine kinase 1	Homo sapiens	158-161
30181701-6	2018	Additionally, curcumin blocked the histamine-induced inward current via activation of TRPV1 (curcumin IC50=523 nM).	Curcumin	14-22	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	86-91
30181701-6	2018	Additionally, curcumin blocked the histamine-induced inward current via activation of TRPV1 (curcumin IC50=523 nM).	Curcumin	93-101	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	86-91
30181701-8	2018	Taken together, our results suggest that histamine-induced itching can be blocked by topical application of curcumin through the inhibitory action of curcumin on TRPV1 receptors in peripheral nerves.	Curcumin	108-116	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	162-167
30181701-8	2018	Taken together, our results suggest that histamine-induced itching can be blocked by topical application of curcumin through the inhibitory action of curcumin on TRPV1 receptors in peripheral nerves.	Curcumin	150-158	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	162-167
29887570-7	2018	Collectively, our data demonstrated that curcumin may suppress cAMP-induced steroidogenesis in mouse Leydig cells by down-regulating Nr5a1/Fos-controlled StAR and Cyp11a1 expression independently of the PKA-CREB signaling pathway.	Curcumin	41-49	cAMP responsive element binding protein 1	Mus musculus	207-211
29806132-5	2018	Curcumin significantly reduced serum levels of NTBI (2.83 +- 1.08 compared with 2.22 +- 0.97 mumol/L, p = .001), ALT (42.86 +- 11.15 compared with 40.60 +- 9.89 U/L, p = .018), and AST (49.45 +- 12.39 compared with 46.30 +- 10.85 U/L, p = .002) at the end of the study.	Curcumin	0-8	solute carrier family 17 member 5	Homo sapiens	181-184
29806132-8	2018	Curcumin administration alleviated iron burden and liver dysfunction by reducing NTBI, ALT, and AST levels in patients with beta-thalassemia major.	Curcumin	0-8	solute carrier family 17 member 5	Homo sapiens	96-99
29723631-5	2018	Furthermore, changes in expression of the ER Stress Response (ERSR) genes IRE1 and ATF6, and the microRNAs (miRNAs) miR-27a, miR-222, miR-449 was observed after exposure to curcumin.	Curcumin	173-181	microRNA 27a	Homo sapiens	116-123
29887570-0	2018	Curcumin downregulates 8-br-cAMP-induced steroidogenesis in mouse Leydig cells by suppressing the expression of Cyp11a1 and StAR independently of the PKA-CREB pathway.	Curcumin	0-8	cAMP responsive element binding protein 1	Mus musculus	154-158
30214301-0	2018	A mono-carbonyl analog of curcumin induces apoptosis in drug-resistant EGFR-mutant lung cancer through the generation of oxidative stress and mitochondrial dysfunction.	Curcumin	26-34	epidermal growth factor receptor	Homo sapiens	71-75
30186159-0	2018	The Curcumin Analogs 2-Pyridyl Cyclohexanone Induce Apoptosis via Inhibition of the JAK2-STAT3 Pathway in Human Esophageal Squamous Cell Carcinoma Cells.	Curcumin	4-12	signal transducer and activator of transcription 3	Homo sapiens	89-94
30304108-9	2018	In the curcumin + alendronate group, BALP and CTx levels decreased and osteocalcin levels increased significantly at the end of study compared to the control and alendronate groups.	Curcumin	7-15	bone gamma-carboxyglutamate protein	Homo sapiens	71-82
30115081-10	2018	RESULTS: Curcumin attenuated the production of IL-1beta and TNF-alpha in rat gingival fibroblasts stimulated by LPS, and inhibited the LPS-induced decrease in OPG/sRANKL ratio and NF-kappaB activation.	Curcumin	9-17	interleukin 1 beta	Rattus norvegicus	47-55
30115081-10	2018	RESULTS: Curcumin attenuated the production of IL-1beta and TNF-alpha in rat gingival fibroblasts stimulated by LPS, and inhibited the LPS-induced decrease in OPG/sRANKL ratio and NF-kappaB activation.	Curcumin	9-17	tumor necrosis factor	Rattus norvegicus	60-69
30076255-0	2018	Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappa B and the serine/threonine kinase Akt and is independent of tubulin polymerization.	Curcumin	44-52	AKT serine/threonine kinase 1	Homo sapiens	136-139
30110401-7	2018	However, pretreatment of rats with Curcumin and/or Gallic acid prior to administration of tramadol restored the inhibited DMN-dI activity and its protein expression (CYP 2E1) to their normal levels.	Curcumin	35-43	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	166-173
30092839-0	2018	Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer"s disease brains: Implications for in-vivo diagnostics.	Curcumin	10-18	amyloid beta precursor protein	Homo sapiens	52-64
30092839-6	2018	We found that curcumin binds to fibrillar amyloid beta (Abeta) in plaques and CAA.	Curcumin	14-22	amyloid beta precursor protein	Homo sapiens	42-54
29770869-0	2018	Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-kappaB signaling and polyamine metabolism in breast cancer cells.	Curcumin	0-8	growth hormone 1	Homo sapiens	28-42
29770869-4	2018	In this study, our aim was to investigate the potential therapeutic effect of curcumin by evaluating the molecular machinery of curcumin-triggered apoptotic cell death via focusing on NF-kappaB signaling and polyamine (PA) metabolism in autocrine GH-expressing MCF-7, MDA-MB-453 and MDA-MB-231 breast cancer cells.	Curcumin	78-86	growth hormone 1	Homo sapiens	247-249
29770869-4	2018	In this study, our aim was to investigate the potential therapeutic effect of curcumin by evaluating the molecular machinery of curcumin-triggered apoptotic cell death via focusing on NF-kappaB signaling and polyamine (PA) metabolism in autocrine GH-expressing MCF-7, MDA-MB-453 and MDA-MB-231 breast cancer cells.	Curcumin	128-136	growth hormone 1	Homo sapiens	247-249
29770869-6	2018	Autocrine GH-induced curcumin resistance was overcome in a dose-dependent manner and curcumin inhibited cell proliferation, invasion-metastasis and phosphorylation of p65 (Ser536), and thereby partly prevented its DNA binding activity in breast cancer cells.	Curcumin	21-29	growth hormone 1	Homo sapiens	10-12
29770869-6	2018	Autocrine GH-induced curcumin resistance was overcome in a dose-dependent manner and curcumin inhibited cell proliferation, invasion-metastasis and phosphorylation of p65 (Ser536), and thereby partly prevented its DNA binding activity in breast cancer cells.	Curcumin	85-93	growth hormone 1	Homo sapiens	10-12
29770869-7	2018	Moreover, curcumin induced caspase-mediated apoptotic cell death by activating the PA catabolic enzyme expressions, which led to generation of toxic by-products such as H2O2 in MCF-7, MDA-MB-453 and MDA-MB-231 GH+ breast cancer cells.	Curcumin	10-18	growth hormone 1	Homo sapiens	210-212
29770869-9	2018	In conclusion, curcumin could overcome the GH-mediated resistant phenotype via modulating cell survival, death-related signaling routes and activating PA catabolic pathway.	Curcumin	15-23	growth hormone 1	Homo sapiens	43-45
29880071-9	2018	Furthermore, compared with the BDL group, we observed an increase in IRS1 and a decrease in SOCS3 and STAT3 expression in the curcumin-treated BDL group (P&lt;0 05), indicating return of these parameters towards normalcy.	Curcumin	126-134	insulin receptor substrate 1	Rattus norvegicus	69-73
29533214-0	2018	Curcumin analogue 1,5-bis(4-hydroxy-3-((4-methylpiperazin-1-yl)methyl)phenyl)penta-1,4-dien-3-one mediates growth arrest and apoptosis by targeting the PI3K/AKT/mTOR and PKC-theta signaling pathways in human breast carcinoma cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	157-160
29533214-0	2018	Curcumin analogue 1,5-bis(4-hydroxy-3-((4-methylpiperazin-1-yl)methyl)phenyl)penta-1,4-dien-3-one mediates growth arrest and apoptosis by targeting the PI3K/AKT/mTOR and PKC-theta signaling pathways in human breast carcinoma cells.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	161-165
29533214-8	2018	In addition, treatment of breast cancer cells with J1 revealed that, in contrast to the expression of cyclin B1, this curcumin analogue vigorously decreased the expression of cyclin A, CDK2 and cyclin E and subsequently sensitized tumor cells to cell cycle arrest.	Curcumin	118-126	cyclin A2	Homo sapiens	175-183
30116377-7	2018	In conclusion, curcumin inhibited the proliferation of breast cancer cells and induced G2/M phase cell cycle arrest and apoptosis, which may be associated with the decrease of CDC25 and CDC2 and increase of P21 protein levels, as well as inhibition of the phosphorylation of Akt/mTOR and induction of the mitochondrial apoptotic pathway.	Curcumin	15-23	AKT serine/threonine kinase 1	Homo sapiens	275-278
30116377-6	2018	In addition, curcumin inhibited the phosphorylation of protein kinase B (Akt)/mammalian target of rapamycin (mTOR), decreased B-cell lymphoma 2 (BCL2) and promoted BCL-2-associated X protein (BAX) and cleavage of caspase 3, subsequently inducing apoptosis of breast cancer cells.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	73-76
30116377-6	2018	In addition, curcumin inhibited the phosphorylation of protein kinase B (Akt)/mammalian target of rapamycin (mTOR), decreased B-cell lymphoma 2 (BCL2) and promoted BCL-2-associated X protein (BAX) and cleavage of caspase 3, subsequently inducing apoptosis of breast cancer cells.	Curcumin	13-21	mechanistic target of rapamycin kinase	Homo sapiens	78-107
30116377-6	2018	In addition, curcumin inhibited the phosphorylation of protein kinase B (Akt)/mammalian target of rapamycin (mTOR), decreased B-cell lymphoma 2 (BCL2) and promoted BCL-2-associated X protein (BAX) and cleavage of caspase 3, subsequently inducing apoptosis of breast cancer cells.	Curcumin	13-21	mechanistic target of rapamycin kinase	Homo sapiens	109-113
30116377-7	2018	In conclusion, curcumin inhibited the proliferation of breast cancer cells and induced G2/M phase cell cycle arrest and apoptosis, which may be associated with the decrease of CDC25 and CDC2 and increase of P21 protein levels, as well as inhibition of the phosphorylation of Akt/mTOR and induction of the mitochondrial apoptotic pathway.	Curcumin	15-23	mechanistic target of rapamycin kinase	Homo sapiens	279-283
30116377-6	2018	In addition, curcumin inhibited the phosphorylation of protein kinase B (Akt)/mammalian target of rapamycin (mTOR), decreased B-cell lymphoma 2 (BCL2) and promoted BCL-2-associated X protein (BAX) and cleavage of caspase 3, subsequently inducing apoptosis of breast cancer cells.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	126-143
30116377-6	2018	In addition, curcumin inhibited the phosphorylation of protein kinase B (Akt)/mammalian target of rapamycin (mTOR), decreased B-cell lymphoma 2 (BCL2) and promoted BCL-2-associated X protein (BAX) and cleavage of caspase 3, subsequently inducing apoptosis of breast cancer cells.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	145-149
30116377-6	2018	In addition, curcumin inhibited the phosphorylation of protein kinase B (Akt)/mammalian target of rapamycin (mTOR), decreased B-cell lymphoma 2 (BCL2) and promoted BCL-2-associated X protein (BAX) and cleavage of caspase 3, subsequently inducing apoptosis of breast cancer cells.	Curcumin	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	164-190
29653171-0	2018	Production of biological nanoparticles from bovine serum albumin as controlled release carrier for curcumin delivery.	Curcumin	99-107	albumin	Homo sapiens	57-64
30116377-6	2018	In addition, curcumin inhibited the phosphorylation of protein kinase B (Akt)/mammalian target of rapamycin (mTOR), decreased B-cell lymphoma 2 (BCL2) and promoted BCL-2-associated X protein (BAX) and cleavage of caspase 3, subsequently inducing apoptosis of breast cancer cells.	Curcumin	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	192-195
30116377-6	2018	In addition, curcumin inhibited the phosphorylation of protein kinase B (Akt)/mammalian target of rapamycin (mTOR), decreased B-cell lymphoma 2 (BCL2) and promoted BCL-2-associated X protein (BAX) and cleavage of caspase 3, subsequently inducing apoptosis of breast cancer cells.	Curcumin	13-21	caspase 3	Homo sapiens	213-222
29653171-1	2018	This study described a curcumin (CUR) loaded bovine serum albumin nanoparticles (BSA@CUR NPs), which could solubilize the poorly water-soluble drug and increase the therapeutic efficacy of the drug.	Curcumin	23-31	albumin	Homo sapiens	58-65
29806793-0	2018	Curcumin reduces the expression of interleukin 1beta and the production of interleukin 6 and tumor necrosis factor alpha by M1 macrophages from patients with Behcet"s disease.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	35-52
29778842-9	2018	The suppressive function of Treg cells was enhanced and the plasma levels of IL-10 increased after treatment with curcumin.	Curcumin	114-122	interleukin 10	Mus musculus	77-82
29778842-10	2018	Furthermore, the secretion of plasma TNF-alpha and IL-6 was notably inhibited in septic mice treated with curcumin and administration with curcumin could improve survival after CLP.	Curcumin	106-114	tumor necrosis factor	Mus musculus	37-46
29778842-10	2018	Furthermore, the secretion of plasma TNF-alpha and IL-6 was notably inhibited in septic mice treated with curcumin and administration with curcumin could improve survival after CLP.	Curcumin	106-114	interleukin 6	Mus musculus	51-55
29778842-10	2018	Furthermore, the secretion of plasma TNF-alpha and IL-6 was notably inhibited in septic mice treated with curcumin and administration with curcumin could improve survival after CLP.	Curcumin	139-147	tumor necrosis factor	Mus musculus	37-46
29778842-10	2018	Furthermore, the secretion of plasma TNF-alpha and IL-6 was notably inhibited in septic mice treated with curcumin and administration with curcumin could improve survival after CLP.	Curcumin	139-147	interleukin 6	Mus musculus	51-55
29806793-0	2018	Curcumin reduces the expression of interleukin 1beta and the production of interleukin 6 and tumor necrosis factor alpha by M1 macrophages from patients with Behcet"s disease.	Curcumin	0-8	interleukin 6	Homo sapiens	75-120
29806793-6	2018	RESULTS: Treatment with 30 microg/ml curcumin significantly down-regulated mRNA expression of IL-1beta (p &lt; .05) and protein production of IL-6 (p &lt; .05) in M1 macrophages from BD patients but not in M1 macrophage from controls.	Curcumin	37-45	interleukin 1 beta	Homo sapiens	94-102
29806793-6	2018	RESULTS: Treatment with 30 microg/ml curcumin significantly down-regulated mRNA expression of IL-1beta (p &lt; .05) and protein production of IL-6 (p &lt; .05) in M1 macrophages from BD patients but not in M1 macrophage from controls.	Curcumin	37-45	interleukin 6	Homo sapiens	142-146
29806793-7	2018	Treatment with 30 microg/ml curcumin also significantly diminishes the protein production of TNFalpha in BD patients (p &lt; .01) and healthy controls (p &lt; .05) M1 macrophages.	Curcumin	28-36	tumor necrosis factor	Homo sapiens	93-101
29659146-0	2018	Curcumin accelerates cutaneous wound healing via multiple biological actions: The involvement of TNF-alpha, MMP-9, alpha-SMA, and collagen.	Curcumin	0-8	tumor necrosis factor	Mus musculus	97-106
29901071-0	2018	Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells.	Curcumin	0-8	tumor associated calcium signal transducer 2	Homo sapiens	69-74
29901071-6	2018	However, whether Trop2 is involved in curcumin-induced BC cell inhibition remains to be elucidated.	Curcumin	38-46	tumor associated calcium signal transducer 2	Homo sapiens	17-22
29901071-7	2018	The present study hypothesized that Trop2 may be a promising target of curcumin in BC cells.	Curcumin	71-79	tumor associated calcium signal transducer 2	Homo sapiens	36-41
29901071-8	2018	It was found that Trop2 was closely involved in curcumin-induced cell proliferation suppression, mobility inhibition, apoptosis, and cell cycle arrest in BC cells.	Curcumin	48-56	tumor associated calcium signal transducer 2	Homo sapiens	18-23
29901071-9	2018	Curcumin decreased the expression of Trop2 and its downstream target cyclin E1, and increased the level of p27.	Curcumin	0-8	tumor associated calcium signal transducer 2	Homo sapiens	37-42
29901071-9	2018	Curcumin decreased the expression of Trop2 and its downstream target cyclin E1, and increased the level of p27.	Curcumin	0-8	dynactin subunit 6	Homo sapiens	107-110
29659146-0	2018	Curcumin accelerates cutaneous wound healing via multiple biological actions: The involvement of TNF-alpha, MMP-9, alpha-SMA, and collagen.	Curcumin	0-8	actin alpha 2, smooth muscle, aorta	Mus musculus	115-124
29901071-10	2018	The overexpression of Trop2 enhanced the oncogenic activity of BC cells, whereas downregulation of the expression of Trop2 suppressed cell proliferation and mobility, increased apoptosis, and sensitized BC cells to curcumin treatment.	Curcumin	215-223	tumor associated calcium signal transducer 2	Homo sapiens	117-122
29901071-11	2018	Therefore, Trop2 may be a promising target of curcumin in BC cells and the inhibition of Trop2 may be an important method for the therapeutic management of patients with BC.	Curcumin	46-54	tumor associated calcium signal transducer 2	Homo sapiens	11-16
29901190-0	2018	Curcumin suppresses cardiac fibroblasts activities by regulating the proliferation and cell cycle via the inhibition of the p38 MAPK/ERK signaling pathway.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	124-127
29901190-8	2018	However, in the absence of TGF-beta1, curcumin did not have any effects on CFs, suggesting that curcumin inhibited TGF-beta1-mediated CF activities, including differentiation and collagen deposition.	Curcumin	96-104	transforming growth factor beta 1	Homo sapiens	115-124
29808357-0	2018	IL-17A suppresses and curcumin up-regulates Akt expression upon bleomycin exposure.	Curcumin	22-30	AKT serine/threonine kinase 1	Homo sapiens	44-47
29808357-7	2018	Administrations of BLM and IL-17A to the alveolar basal epithelial cells showed significant down-regulation of Akt expression which was reversed by treatment with curcumin.	Curcumin	163-171	AKT serine/threonine kinase 1	Homo sapiens	111-114
29901190-9	2018	Additionally, curcumin inhibited the proliferation of TGF-beta1-treated CFs, and promoted G2/M phase cell cycle arrest.	Curcumin	14-22	transforming growth factor beta 1	Homo sapiens	54-63
29901190-0	2018	Curcumin suppresses cardiac fibroblasts activities by regulating the proliferation and cell cycle via the inhibition of the p38 MAPK/ERK signaling pathway.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	133-136
29901190-10	2018	Curcumin reduced cell cycle protein expression by inhibiting smad2/3, p38 mitogen-activated protein kinase, and ERK phosphorylation in TGF-beta1-treated CFs.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	70-73
29901190-10	2018	Curcumin reduced cell cycle protein expression by inhibiting smad2/3, p38 mitogen-activated protein kinase, and ERK phosphorylation in TGF-beta1-treated CFs.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	112-115
29901190-7	2018	Curcumin significantly reduced mRNA and protein levels of alpha-SMA, COLA1, and COLA3 in CFs stimulated with TGF-beta1.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	109-118
29901190-10	2018	Curcumin reduced cell cycle protein expression by inhibiting smad2/3, p38 mitogen-activated protein kinase, and ERK phosphorylation in TGF-beta1-treated CFs.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	135-144
30055772-0	2018	Supplementation with curcumin inhibits intestinal cholesterol absorption and prevents atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice.	Curcumin	21-29	apolipoprotein E	Mus musculus	123-139
30055772-4	2018	Here, we tested the hypothesis that supplementation with curcumin can also reduce intestinal cholesterol absorption in high-fat diet-fed apolipoprotein E knockout (ApoE-/-) mice and prevent atherosclerosis development.	Curcumin	57-65	apolipoprotein E	Mus musculus	137-153
30055772-4	2018	Here, we tested the hypothesis that supplementation with curcumin can also reduce intestinal cholesterol absorption in high-fat diet-fed apolipoprotein E knockout (ApoE-/-) mice and prevent atherosclerosis development.	Curcumin	57-65	apolipoprotein E	Mus musculus	164-168
30055772-10	2018	These findings support the hypothesis that curcumin supplementation reduces intestinal cholesterol absorption and prevents atherosclerosis in high-fat diet-fed ApoE-/- mice.	Curcumin	43-51	apolipoprotein E	Mus musculus	160-164
30045750-0	2018	SWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1alpha axis.	Curcumin	61-69	microRNA 22	Homo sapiens	148-154
33168498-5	2018	Western blotting showed that treatment of the siRNA-transfected SHI-1 cells with 0-25 mumol/L curcumin or with 0-2.0 mumol/L Ara-C further increased the cell inhibition rate and obviously enhanced the expressions of p-P38 MAPK and p-JNK without significantly affecting p-ERK expression.	Curcumin	94-102	mitogen-activated protein kinase 8	Homo sapiens	233-236
33168498-5	2018	Western blotting showed that treatment of the siRNA-transfected SHI-1 cells with 0-25 mumol/L curcumin or with 0-2.0 mumol/L Ara-C further increased the cell inhibition rate and obviously enhanced the expressions of p-P38 MAPK and p-JNK without significantly affecting p-ERK expression.	Curcumin	94-102	mitogen-activated protein kinase 1	Homo sapiens	271-274
30045750-0	2018	SWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1alpha axis.	Curcumin	61-69	importin 7	Homo sapiens	155-159
30045750-10	2018	Finally, K562 cells transfected with miR-22 inhibitor were used to confirm the ability of curcumin to elicit miR-22 expression.	Curcumin	90-98	microRNA 22	Homo sapiens	109-115
30045750-11	2018	RESULTS: Our findings revealed that the most relevant effect induced by curcumin was a consistent decrease of several proteins involved in glucose metabolism, most of which were HIF-1alpha targets, concomitant with the up-regulation of functional and structural mitochondrial proteins.	Curcumin	72-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	178-188
30045750-12	2018	The mechanism by which curcumin affects metabolic enzyme profile was associated with the reduction of HIF-1alpha activity, due to the miR-22-mediated down-regulation of IPO7 expression.	Curcumin	23-31	microRNA 22	Homo sapiens	134-140
30045750-12	2018	The mechanism by which curcumin affects metabolic enzyme profile was associated with the reduction of HIF-1alpha activity, due to the miR-22-mediated down-regulation of IPO7 expression.	Curcumin	23-31	importin 7	Homo sapiens	169-173
30045750-14	2018	CONCLUSIONS: In summary, our data indicates that the miR-22/IPO7/HIF-1alpha axis may be considered as a novel molecular target of curcumin adding new insights to better define therapeutic activity and anticancer properties of this natural compound.	Curcumin	130-138	microRNA 22	Homo sapiens	53-59
30045750-14	2018	CONCLUSIONS: In summary, our data indicates that the miR-22/IPO7/HIF-1alpha axis may be considered as a novel molecular target of curcumin adding new insights to better define therapeutic activity and anticancer properties of this natural compound.	Curcumin	130-138	importin 7	Homo sapiens	60-64
30021002-4	2018	The coreshell SPIONs were found to be releasing curcumin in between 6 and 12 h, which was evidenced by increased apoptotic cells and increased caspase 3 expression in HeLa cells.	Curcumin	48-56	caspase 3	Homo sapiens	143-152
30037344-4	2018	Curcumin is known to have anti-inflammatory and anti-oxidant effects and has been reported to inhibit the mTOR pathway.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	106-110
30037344-10	2018	Quantitative real-time PCR analysis revealed that curcumin, but not rapamycin, reduced the levels of inflammatory markers IL-6 and COX-2 in cultured astrocytes that were challenged with IL-1beta.	Curcumin	50-58	interleukin 6	Homo sapiens	122-126
30037344-10	2018	Quantitative real-time PCR analysis revealed that curcumin, but not rapamycin, reduced the levels of inflammatory markers IL-6 and COX-2 in cultured astrocytes that were challenged with IL-1beta.	Curcumin	50-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
30037344-10	2018	Quantitative real-time PCR analysis revealed that curcumin, but not rapamycin, reduced the levels of inflammatory markers IL-6 and COX-2 in cultured astrocytes that were challenged with IL-1beta.	Curcumin	50-58	interleukin 1 beta	Homo sapiens	186-194
29998888-0	2018	Curcumin Inhibits Lipopolysaccharide-Induced Mucin 5AC Hypersecretion and Airway Inflammation via Nuclear Factor Erythroid 2-Related Factor 2.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	98-141
30012134-0	2018	Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-kappaB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT).	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	127-136
30012134-0	2018	Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-kappaB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT).	Curcumin	0-8	interleukin 6	Homo sapiens	79-92
29980703-5	2018	We also characterised their effects in ex-vivo psoriasis PBMC and report that curcumin, but not carnosol, strongly reduces T cell proliferation and cytokine poly-functionality, with reduced expression of psoriatic cytokines IFNgamma, IL-17, GM-CSF and IL-22.	Curcumin	78-86	interferon gamma	Homo sapiens	224-232
29567499-1	2018	The purpose of this study was to fabricate redox-responsive human serum albumin (HSA) nanoparticles (NPs) through self-assembly of HSA molecules for incorporation of curcumin (CCM) as a hydrophobic drug molecule.	Curcumin	166-174	albumin	Homo sapiens	81-84
29567499-1	2018	The purpose of this study was to fabricate redox-responsive human serum albumin (HSA) nanoparticles (NPs) through self-assembly of HSA molecules for incorporation of curcumin (CCM) as a hydrophobic drug molecule.	Curcumin	166-174	albumin	Homo sapiens	131-134
29567499-1	2018	The purpose of this study was to fabricate redox-responsive human serum albumin (HSA) nanoparticles (NPs) through self-assembly of HSA molecules for incorporation of curcumin (CCM) as a hydrophobic drug molecule.	Curcumin	176-179	albumin	Homo sapiens	81-84
29567499-1	2018	The purpose of this study was to fabricate redox-responsive human serum albumin (HSA) nanoparticles (NPs) through self-assembly of HSA molecules for incorporation of curcumin (CCM) as a hydrophobic drug molecule.	Curcumin	176-179	albumin	Homo sapiens	131-134
30057682-0	2018	Curcumin Modulates DNA Methyltransferase Functions in a Cellular Model of Diabetic Retinopathy.	Curcumin	0-8	DNA methyltransferase (cytosine-5) 1	Mus musculus	19-40
29802156-13	2018	In vitro, curcumin treatment improved IL-1beta induced autophagy inhibition, cell viability decrease, and apoptosis.	Curcumin	10-18	interleukin 1 beta	Mus musculus	38-46
29802156-14	2018	Mechanistically, in vivo studies suggested curcumin promoted autophagy through regulating Akt/mTOR pathway.	Curcumin	43-51	thymoma viral proto-oncogene 1	Mus musculus	90-93
29802156-15	2018	In conclusion, our results demonstrate that curcumin-induced autophagy via Akt/mTOR signaling pathway contributes to the anti-OA effect of curcumin.	Curcumin	44-52	thymoma viral proto-oncogene 1	Mus musculus	75-78
29802156-15	2018	In conclusion, our results demonstrate that curcumin-induced autophagy via Akt/mTOR signaling pathway contributes to the anti-OA effect of curcumin.	Curcumin	139-147	thymoma viral proto-oncogene 1	Mus musculus	75-78
29787434-9	2018	Curcumin also affected CCNG1 and PHPT1 transcriptional response counteracting some of the radiation induction.	Curcumin	0-8	phosphohistidine phosphatase 1	Homo sapiens	33-38
30377591-0	2018	The effects of curcumin and a modified curcumin formulation on serum Cholesteryl Ester Transfer Protein concentrations in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial.	Curcumin	39-47	cholesteryl ester transfer protein	Homo sapiens	69-103
30377591-2	2018	The aim of the present trial was to evaluate the effect of curcumin and its modified formulation on serum CETP concentrations in patients with metabolic syndrome.	Curcumin	59-67	cholesteryl ester transfer protein	Homo sapiens	106-110
29677548-11	2018	Additionally, the phosphorylation levels of AKT and ERK2 were both increased by combination of curcumin and VNS compared with the CI/RI + VNS group.	Curcumin	95-103	AKT serine/threonine kinase 1	Rattus norvegicus	44-47
29072510-7	2018	We anticipate that the induction of antioxidant enzymes by curcumin would activate Nrf2-Keap1 pathway as the plausible mechanism to exert anti-inflammatory response as demonstrated in renal epithelial cells.	Curcumin	59-67	NFE2 like bZIP transcription factor 2	Homo sapiens	83-87
29072510-7	2018	We anticipate that the induction of antioxidant enzymes by curcumin would activate Nrf2-Keap1 pathway as the plausible mechanism to exert anti-inflammatory response as demonstrated in renal epithelial cells.	Curcumin	59-67	kelch like ECH associated protein 1	Homo sapiens	88-93
30057682-6	2018	Interestingly, treatment with 25 muM curcumin for 6 hours restores ROS production, as well as DNMT functions, altered by the exposure of RPE to acute and chronic high glucose concentration.	Curcumin	37-45	DNA methyltransferase (cytosine-5) 1	Mus musculus	94-98
30057682-7	2018	Our study suggests that curcumin may represent an effective antioxidant compound against DR, via restoring oxidative stress and DNMT functions, though further studies are recommended.	Curcumin	24-32	DNA methyltransferase (cytosine-5) 1	Mus musculus	128-132
29715758-0	2018	NGF and PI3K/Akt signaling participate in the ventral motor neuronal protection of curcumin in sciatic nerve injury rat models.	Curcumin	83-91	AKT serine/threonine kinase 1	Rattus norvegicus	13-16
29715758-4	2018	In the present study, we attempt to investigate underlying mechanism of neuroprotective effect of curcumin through elucidating its correlation with NGF and PI3K/Akt signaling pathways in vitro and in vivo.	Curcumin	98-106	AKT serine/threonine kinase 1	Rattus norvegicus	161-164
29715758-10	2018	RESULTS: Curcumin significantly reduced the number of apoptotic cells induced by H2O2 and this effect was associated with upregulation of TrkA, Akt and downregulation of p17.	Curcumin	9-17	AKT serine/threonine kinase 1	Rattus norvegicus	144-147
29715758-13	2018	In addition, inhibition of PI3K/Akt results in increased apoptotic rate compared to vehicles following curcumin treatment which was reflected by decreased p17, Ki67, and cyclin D1.	Curcumin	103-111	AKT serine/threonine kinase 1	Rattus norvegicus	32-35
29715758-13	2018	In addition, inhibition of PI3K/Akt results in increased apoptotic rate compared to vehicles following curcumin treatment which was reflected by decreased p17, Ki67, and cyclin D1.	Curcumin	103-111	cyclin D1	Rattus norvegicus	170-179
29715758-15	2018	CONCLUSION: Our findings revealed that curcumin exerts its protective effect against injured neurons through stimulating NGF release which further activates TrkA and PI3K/Akt cell survival signaling.	Curcumin	39-47	AKT serine/threonine kinase 1	Rattus norvegicus	171-174
29080256-0	2018	Curcumin attenuates high glucose-induced inflammatory injury through the reactive oxygen species-phosphoinositide 3-kinase/protein kinase B-nuclear factor-kappaB signaling pathway in rat thoracic aorta endothelial cells.	Curcumin	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	89-122
29620257-5	2018	In addition, curcumin treatment prevented EGF-induced phosphorylation of EGF receptor (EGFR) as well as the downstream AKT and signal transducer and activator of transcription 3 (STAT3), while inhibition of PI3K and STAT3 signaling significantly attenuated the expression of MUC5AC that was induced by EGF.	Curcumin	13-21	epidermal growth factor receptor	Homo sapiens	73-85
29620257-5	2018	In addition, curcumin treatment prevented EGF-induced phosphorylation of EGF receptor (EGFR) as well as the downstream AKT and signal transducer and activator of transcription 3 (STAT3), while inhibition of PI3K and STAT3 signaling significantly attenuated the expression of MUC5AC that was induced by EGF.	Curcumin	13-21	epidermal growth factor receptor	Homo sapiens	87-91
29620257-5	2018	In addition, curcumin treatment prevented EGF-induced phosphorylation of EGF receptor (EGFR) as well as the downstream AKT and signal transducer and activator of transcription 3 (STAT3), while inhibition of PI3K and STAT3 signaling significantly attenuated the expression of MUC5AC that was induced by EGF.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	119-122
29620257-5	2018	In addition, curcumin treatment prevented EGF-induced phosphorylation of EGF receptor (EGFR) as well as the downstream AKT and signal transducer and activator of transcription 3 (STAT3), while inhibition of PI3K and STAT3 signaling significantly attenuated the expression of MUC5AC that was induced by EGF.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	127-177
29620257-5	2018	In addition, curcumin treatment prevented EGF-induced phosphorylation of EGF receptor (EGFR) as well as the downstream AKT and signal transducer and activator of transcription 3 (STAT3), while inhibition of PI3K and STAT3 signaling significantly attenuated the expression of MUC5AC that was induced by EGF.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	179-184
29620257-5	2018	In addition, curcumin treatment prevented EGF-induced phosphorylation of EGF receptor (EGFR) as well as the downstream AKT and signal transducer and activator of transcription 3 (STAT3), while inhibition of PI3K and STAT3 signaling significantly attenuated the expression of MUC5AC that was induced by EGF.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	216-221
29620257-6	2018	Furthermore, EGF-induced increases in the levels of phosphorylated STAT3 in the nuclear fraction were inhibited by curcumin and PI3K inhibitors.	Curcumin	115-123	signal transducer and activator of transcription 3	Homo sapiens	67-72
29620257-7	2018	In addition, treatment with curcumin significantly decreased MUC5AC and EGFR expression in a time-dependent manner under basal conditions.	Curcumin	28-36	epidermal growth factor receptor	Homo sapiens	72-76
29620257-9	2018	This inhibition was accompanied by decreased activation of the EGFR/AKT/STAT3 pathway and reduced EGFR expression, which indicated that curcumin may have a dual role in interfering with the EGFR signaling pathway and inhibiting mucin expression in human airway epithelial cells.	Curcumin	136-144	epidermal growth factor receptor	Homo sapiens	63-67
29620257-9	2018	This inhibition was accompanied by decreased activation of the EGFR/AKT/STAT3 pathway and reduced EGFR expression, which indicated that curcumin may have a dual role in interfering with the EGFR signaling pathway and inhibiting mucin expression in human airway epithelial cells.	Curcumin	136-144	AKT serine/threonine kinase 1	Homo sapiens	68-71
29620257-9	2018	This inhibition was accompanied by decreased activation of the EGFR/AKT/STAT3 pathway and reduced EGFR expression, which indicated that curcumin may have a dual role in interfering with the EGFR signaling pathway and inhibiting mucin expression in human airway epithelial cells.	Curcumin	136-144	signal transducer and activator of transcription 3	Homo sapiens	72-77
29620257-9	2018	This inhibition was accompanied by decreased activation of the EGFR/AKT/STAT3 pathway and reduced EGFR expression, which indicated that curcumin may have a dual role in interfering with the EGFR signaling pathway and inhibiting mucin expression in human airway epithelial cells.	Curcumin	136-144	epidermal growth factor receptor	Homo sapiens	98-102
29620257-9	2018	This inhibition was accompanied by decreased activation of the EGFR/AKT/STAT3 pathway and reduced EGFR expression, which indicated that curcumin may have a dual role in interfering with the EGFR signaling pathway and inhibiting mucin expression in human airway epithelial cells.	Curcumin	136-144	epidermal growth factor receptor	Homo sapiens	98-102
29620257-0	2018	Curcumin suppresses MUC5AC production via interfering with the EGFR signaling pathway.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	63-67
29600521-0	2018	Phytosomal-curcumin antagonizes cell growth and migration, induced by thrombin through AMP-Kinase in breast cancer.	Curcumin	11-19	coagulation factor II, thrombin	Homo sapiens	70-78
29600521-8	2018	Curcumin reduced the invasiveness of MCF-7 through perturbation of E-cadherin.	Curcumin	0-8	cadherin 1	Homo sapiens	67-77
29600521-12	2018	Of note, curcumin reduced cyclinD-expression in breast cancer cell treated with thrombin, and activates AMPK in a time-dependent manner.	Curcumin	9-17	coagulation factor II, thrombin	Homo sapiens	80-88
29600521-13	2018	Also suppression of AMPK abrogated inhibitory effect of phytosomal-curcumin on thrombin-induced cyclin D1 over-expression, suggesting that AMPK is essential for anti-proliferative effect of this agent in breast cancer.	Curcumin	67-75	coagulation factor II, thrombin	Homo sapiens	79-87
29600521-14	2018	Our finding demonstrated that phytosomal-curcumin antagonizes cell growth and migration, induced by thrombin through AMP-Kinase in breast cancer, supporting further-investigations on the therapeutic potential of this novel anticancer agent in treatment of breast cancer.	Curcumin	41-49	coagulation factor II, thrombin	Homo sapiens	100-108
29080256-11	2018	CONCLUSION: Curcumin attenuates high glucose-induced inflammatory injury through the reactive oxygen species-PI3K/AKT-NF-kappaB signaling pathway in rat thoracic aorta endothelial cells.	Curcumin	12-20	AKT serine/threonine kinase 1	Rattus norvegicus	114-117
29702753-0	2018	Curcumin reverses diabetes-induced endothelial progenitor cell dysfunction by enhancing MnSOD expression and activity in vitro and in vivo.	Curcumin	0-8	superoxide dismutase 2, mitochondrial	Mus musculus	88-93
29800814-0	2018	Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells: implications for the inhibition of protein synthesis and TNFalpha signaling.	Curcumin	21-29	tumor necrosis factor	Homo sapiens	165-173
29800814-10	2018	Curcumin, piperine and their combination inhibited TNFalpha gene expression at baseline but failed to do so under conditions of mTORC1 hyperactivation.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	51-59
29800814-11	2018	TNF -induced cyclooxygenase-2 expression was repressed by curcumin or curcumin + piperine at baseline and high mTORC1 levels.	Curcumin	58-66	tumor necrosis factor	Homo sapiens	0-3
29800814-11	2018	TNF -induced cyclooxygenase-2 expression was repressed by curcumin or curcumin + piperine at baseline and high mTORC1 levels.	Curcumin	58-66	prostaglandin-endoperoxide synthase 2	Homo sapiens	13-29
29800814-11	2018	TNF -induced cyclooxygenase-2 expression was repressed by curcumin or curcumin + piperine at baseline and high mTORC1 levels.	Curcumin	70-78	tumor necrosis factor	Homo sapiens	0-3
29800814-11	2018	TNF -induced cyclooxygenase-2 expression was repressed by curcumin or curcumin + piperine at baseline and high mTORC1 levels.	Curcumin	70-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	13-29
29723552-0	2018	PI3K/Akt/GSK3beta induced CREB activation ameliorates arsenic mediated alterations in NMDA receptors and associated signaling in rat hippocampus: Neuroprotective role of curcumin.	Curcumin	170-178	AKT serine/threonine kinase 1	Rattus norvegicus	5-8
29723552-7	2018	Curcumin was found to decrease sodium arsenite induced changes in hippocampus by modulating PI3K/Akt/GSK3beta neuronal survival pathway, known to regulate various cellular events.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
29723552-10	2018	The results provide evidence that curcumin exercises its neuroprotective effect involving PI3K/Akt pathway which may affect NMDA receptors and downstream signalling through TrKbeta and BDNF in arsenic induced cognitive deficits in hippocampus.	Curcumin	34-42	AKT serine/threonine kinase 1	Rattus norvegicus	95-98
29723552-10	2018	The results provide evidence that curcumin exercises its neuroprotective effect involving PI3K/Akt pathway which may affect NMDA receptors and downstream signalling through TrKbeta and BDNF in arsenic induced cognitive deficits in hippocampus.	Curcumin	34-42	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	173-180
30001775-10	2018	Curcumin (0.6 muM) significantly reduced BrdU+-positive cells, declined the expression of CyclinD1, and enhanced cell apoptosis.	Curcumin	0-8	latexin	Homo sapiens	14-17
30001775-12	2018	In addition, we also found that curcumin inhibited Wnt and mTOR pathways through down-regulation of UCA1.	Curcumin	32-40	mechanistic target of rapamycin kinase	Homo sapiens	59-63
30009570-6	2018	Curcumin prevention (8WD vs. 8WD+C) attenuated (P &lt; 0.05) histological liver inflammation, molecular markers of fibrosis (Col1a1 mRNA) and a serum marker of liver injury (AST).	Curcumin	0-8	collagen type I alpha 1 chain	Rattus norvegicus	125-131
30009570-8	2018	Moreover, curcumin treatment also increased hepatic pACC/ACC, ApoB100, and SOD1 protein, and decreased hepatic FGF-21 levels; whereas, curcumin prevention increased hepatic glutathione levels.	Curcumin	10-18	apolipoprotein B	Rattus norvegicus	62-69
30009570-8	2018	Moreover, curcumin treatment also increased hepatic pACC/ACC, ApoB100, and SOD1 protein, and decreased hepatic FGF-21 levels; whereas, curcumin prevention increased hepatic glutathione levels.	Curcumin	10-18	superoxide dismutase 1	Rattus norvegicus	75-79
30009570-9	2018	Both curcumin prevention and treatment reduced molecular markers of hepatic fibrosis (Col1a1 mRNA) and inflammation (TNF-alpha, SPP1 mRNA).	Curcumin	5-13	collagen type I alpha 1 chain	Rattus norvegicus	86-92
30009570-9	2018	Both curcumin prevention and treatment reduced molecular markers of hepatic fibrosis (Col1a1 mRNA) and inflammation (TNF-alpha, SPP1 mRNA).	Curcumin	5-13	tumor necrosis factor	Rattus norvegicus	117-126
29702753-9	2018	The levels and activity of manganese superoxide dismutase (MnSOD) in D-EPCs treated in vitro with curcumin or those isolated from curcumin-treated diabetic mice were comparable with those in non-diabetic EPCs.	Curcumin	98-106	superoxide dismutase 2, mitochondrial	Mus musculus	27-57
29702753-9	2018	The levels and activity of manganese superoxide dismutase (MnSOD) in D-EPCs treated in vitro with curcumin or those isolated from curcumin-treated diabetic mice were comparable with those in non-diabetic EPCs.	Curcumin	98-106	superoxide dismutase 2, mitochondrial	Mus musculus	59-64
29702753-9	2018	The levels and activity of manganese superoxide dismutase (MnSOD) in D-EPCs treated in vitro with curcumin or those isolated from curcumin-treated diabetic mice were comparable with those in non-diabetic EPCs.	Curcumin	130-138	superoxide dismutase 2, mitochondrial	Mus musculus	27-57
29702753-9	2018	The levels and activity of manganese superoxide dismutase (MnSOD) in D-EPCs treated in vitro with curcumin or those isolated from curcumin-treated diabetic mice were comparable with those in non-diabetic EPCs.	Curcumin	130-138	superoxide dismutase 2, mitochondrial	Mus musculus	59-64
29702753-10	2018	Addition of methyl mercury chloride to inhibit MnSOD activity during curcumin treatment abolished the salutary effects of curcumin.	Curcumin	69-77	superoxide dismutase 2, mitochondrial	Mus musculus	47-52
29702753-10	2018	Addition of methyl mercury chloride to inhibit MnSOD activity during curcumin treatment abolished the salutary effects of curcumin.	Curcumin	122-130	superoxide dismutase 2, mitochondrial	Mus musculus	47-52
29702753-11	2018	Our data demonstrate that curcumin reverses DM-induced EPCD by boosting MnSOD expression and activity and emphasizes its potential for use in autologous cell therapy for diabetic wound management.	Curcumin	26-34	superoxide dismutase 2, mitochondrial	Mus musculus	72-77
29966255-0	2018	The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1.	Curcumin	4-12	tumor protein p53	Homo sapiens	119-122
29751106-8	2018	In the MCF-7/CLC co-culture, curcumin significantly down-regulated RC3H1, a repressor of inflammatory signaling.	Curcumin	29-37	ring finger and CCCH-type domains 1	Homo sapiens	67-72
29751106-9	2018	In the ZR-75-1/CLC co-culture, curcumin significantly down-regulated PEG10, an anti-apoptotic protein, and induced RRAGA, a pro-apoptotic protein involved in TNF-alpha signaling.	Curcumin	31-39	paternally expressed 10	Homo sapiens	69-74
29751106-9	2018	In the ZR-75-1/CLC co-culture, curcumin significantly down-regulated PEG10, an anti-apoptotic protein, and induced RRAGA, a pro-apoptotic protein involved in TNF-alpha signaling.	Curcumin	31-39	tumor necrosis factor	Homo sapiens	158-167
29966255-8	2018	These results suggest that CH-5 has potentially higher anticancer activity than curcumin, which is associated with the expression of apoptosis-associated genes regulated by the transcription factors Sp1 and p53.	Curcumin	80-88	tumor protein p53	Homo sapiens	207-210
30013474-6	2018	Curcumin (10 muM) decreased significantly (p &lt; 0.01) ROS concentration and TNF-alpha release in retinal pigmented epithelial cells and retinal endothelial cells, respectively.	Curcumin	0-8	latexin	Homo sapiens	13-16
30013474-6	2018	Curcumin (10 muM) decreased significantly (p &lt; 0.01) ROS concentration and TNF-alpha release in retinal pigmented epithelial cells and retinal endothelial cells, respectively.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	78-87
29950857-0	2018	Curcumin suppresses the progression of laryngeal squamous cell carcinoma through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	136-139
29942246-6	2018	Results: Results showed that in spite of high degradation rates, boiled curcumin mixture still possessed similar protective activities like parent curcumin, and could effectively rescue PC12 cells against H2O2-induced damage, via decreasing production of reactive oxygen species and malondialdehyde, reducing caspase-3 and caspase-9 activities.	Curcumin	72-80	caspase 9	Rattus norvegicus	323-332
29950857-0	2018	Curcumin suppresses the progression of laryngeal squamous cell carcinoma through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	140-144
29950857-5	2018	The effects of miR-145 combined with curcumin on the phosphoinositol 1,3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway were detected by Western blot analysis.	Curcumin	37-45	mechanistic target of rapamycin kinase	Homo sapiens	110-139
29950857-10	2018	Curcumin treatment dramatically aggravated miR-145-induced inhibition of the PI3K/Akt/mTOR pathway and reversed anti-miR-145-mediated activation of the PI3K/Akt/mTOR pathway in LSCC cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	82-85
29950857-10	2018	Curcumin treatment dramatically aggravated miR-145-induced inhibition of the PI3K/Akt/mTOR pathway and reversed anti-miR-145-mediated activation of the PI3K/Akt/mTOR pathway in LSCC cells.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	86-90
29950857-10	2018	Curcumin treatment dramatically aggravated miR-145-induced inhibition of the PI3K/Akt/mTOR pathway and reversed anti-miR-145-mediated activation of the PI3K/Akt/mTOR pathway in LSCC cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	157-160
29950857-10	2018	Curcumin treatment dramatically aggravated miR-145-induced inhibition of the PI3K/Akt/mTOR pathway and reversed anti-miR-145-mediated activation of the PI3K/Akt/mTOR pathway in LSCC cells.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	161-165
29950857-11	2018	Conclusion: Curcumin suppressed LSCC progression through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway.	Curcumin	12-20	AKT serine/threonine kinase 1	Homo sapiens	112-115
29950857-11	2018	Conclusion: Curcumin suppressed LSCC progression through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway.	Curcumin	12-20	mechanistic target of rapamycin kinase	Homo sapiens	116-120
29679536-6	2018	In HL cells in culture, curcumin decreased the expression of relevant anti-inflammatory cytokines (IL-6 and TNF-alpha) in a concentration-dependent manner.	Curcumin	24-32	interleukin 6	Mus musculus	99-103
29679536-6	2018	In HL cells in culture, curcumin decreased the expression of relevant anti-inflammatory cytokines (IL-6 and TNF-alpha) in a concentration-dependent manner.	Curcumin	24-32	tumor necrosis factor	Mus musculus	108-117
29626606-0	2018	Curcumin provides neuroprotection in model of traumatic brain injury via the Nrf2-ARE signaling pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
29635184-0	2018	Diketo modification of curcumin affects its interaction with human serum albumin.	Curcumin	23-31	albumin	Homo sapiens	67-80
29899429-0	2018	Dietary Intake of Curcumin Improves eIF2 Signaling and Reduces Lipid Levels in the White Adipose Tissue of Obese Mice.	Curcumin	18-26	eukaryotic translation initiation factor 2, subunit 2 (beta)	Mus musculus	36-40
29899429-5	2018	Curcumin accumulated in eWAT and changed gene expressions related to eukaryotic translation initiation factor 2 (eIF2) signalling.	Curcumin	0-8	eukaryotic translation initiation factor 2, subunit 2 (beta)	Mus musculus	69-111
29899429-5	2018	Curcumin accumulated in eWAT and changed gene expressions related to eukaryotic translation initiation factor 2 (eIF2) signalling.	Curcumin	0-8	eukaryotic translation initiation factor 2, subunit 2 (beta)	Mus musculus	113-117
29899429-6	2018	Curcumin suppressed eIF2alpha phosphorylation, which is induced by endoplasmic reticulum (ER) stress, macrophage accumulation and nuclear factor-kappaB (NF-kappaB) p65 and leptin expression, whereas it"s anti-inflammatory effect was inadequate to decrease TNF-alpha and IFN-gamma levels.	Curcumin	0-8	tumor necrosis factor	Mus musculus	256-265
29899429-6	2018	Curcumin suppressed eIF2alpha phosphorylation, which is induced by endoplasmic reticulum (ER) stress, macrophage accumulation and nuclear factor-kappaB (NF-kappaB) p65 and leptin expression, whereas it"s anti-inflammatory effect was inadequate to decrease TNF-alpha and IFN-gamma levels.	Curcumin	0-8	interferon gamma	Mus musculus	270-279
31032585-12	2018	Curcumin can up-regulate expression of Nrf2 and HO-1, effectively alleviates oxidative stress induced by overtraining, thereby increasing Bcl-2 expression, decreasing Bax expression, inhibiting renal apoptosis and protecting renal tissue structure and function properly.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	39-43
31032585-12	2018	Curcumin can up-regulate expression of Nrf2 and HO-1, effectively alleviates oxidative stress induced by overtraining, thereby increasing Bcl-2 expression, decreasing Bax expression, inhibiting renal apoptosis and protecting renal tissue structure and function properly.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	138-143
30020315-0	2018	A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1.	Curcumin	2-10	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	145-149
30020315-0	2018	A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1.	Curcumin	2-10	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	153-158
29626606-5	2018	Curcumin possessed anti-apoptotic character evidenced by elevating Bcl-2 content and reducing that of cleaved caspase-3.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	67-72
29626606-6	2018	Moreover, curcumin markedly enhanced the translocation of Nrf2 from the cytoplasm to the nucleus, proved by the results of western blot and immunofluorescence, subsequently increased the expression of downstream factors such as heme oxygenase 1 (HO1) and NAD(P)H: quinone oxidoreductase 1 (NQO1) and prevented the decline of antioxidant enzyme activities.	Curcumin	10-18	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
29626606-6	2018	Moreover, curcumin markedly enhanced the translocation of Nrf2 from the cytoplasm to the nucleus, proved by the results of western blot and immunofluorescence, subsequently increased the expression of downstream factors such as heme oxygenase 1 (HO1) and NAD(P)H: quinone oxidoreductase 1 (NQO1) and prevented the decline of antioxidant enzyme activities.	Curcumin	10-18	NAD(P)H quinone dehydrogenase 1	Homo sapiens	255-288
29626606-6	2018	Moreover, curcumin markedly enhanced the translocation of Nrf2 from the cytoplasm to the nucleus, proved by the results of western blot and immunofluorescence, subsequently increased the expression of downstream factors such as heme oxygenase 1 (HO1) and NAD(P)H: quinone oxidoreductase 1 (NQO1) and prevented the decline of antioxidant enzyme activities.	Curcumin	10-18	NAD(P)H quinone dehydrogenase 1	Homo sapiens	290-294
29626606-7	2018	In conclusion, curcumin could increase the activities of antioxidant enzymes and attenuate brain injury in the model of TBI, possibly via the activation of the Nrf2-ARE pathway.	Curcumin	15-23	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164
29052798-0	2018	Curcumin pretreatment prevents hydrogen peroxide-induced oxidative stress through enhanced mitochondrial function and deactivation of Akt/Erk signaling pathways in rat bone marrow mesenchymal stem cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	134-137
28926094-0	2018	Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling.	Curcumin	0-8	tumor protein p53	Homo sapiens	105-108
28926094-1	2018	In this study, we aimed to investigate the effects of curcumin on cell activities of gastric cancer (GC), and the connection between curcumin and P53, as well as, PI3K signaling.	Curcumin	133-141	tumor protein p53	Homo sapiens	146-149
28926094-4	2018	Western blot assay was also employed to detect impacts of curcumin on tophosphatidylinositol-3 kinase (PI3K) and P53 signaling pathways-related proteins.	Curcumin	58-66	tumor protein p53	Homo sapiens	113-116
28926094-8	2018	Western blot results showed that curcumin activated P53 signaling pathway and inhibited PI3K signaling pathway.	Curcumin	33-41	tumor protein p53	Homo sapiens	52-55
28926094-10	2018	Additionally, curcumin activated the P53 signaling pathway by up-regulating P53 and P21, which also inhibited PI3K pathway through down-regulating PI3K, p-Akt, and p-mTOR.	Curcumin	14-22	tumor protein p53	Homo sapiens	37-40
28926094-10	2018	Additionally, curcumin activated the P53 signaling pathway by up-regulating P53 and P21, which also inhibited PI3K pathway through down-regulating PI3K, p-Akt, and p-mTOR.	Curcumin	14-22	tumor protein p53	Homo sapiens	76-79
28926094-10	2018	Additionally, curcumin activated the P53 signaling pathway by up-regulating P53 and P21, which also inhibited PI3K pathway through down-regulating PI3K, p-Akt, and p-mTOR.	Curcumin	14-22	mechanistic target of rapamycin kinase	Homo sapiens	166-170
29052798-0	2018	Curcumin pretreatment prevents hydrogen peroxide-induced oxidative stress through enhanced mitochondrial function and deactivation of Akt/Erk signaling pathways in rat bone marrow mesenchymal stem cells.	Curcumin	0-8	Eph receptor B1	Rattus norvegicus	138-141
29052798-6	2018	In addition, curcumin pretreatment markedly reduced the phosphorylation levels of Akt and Erk1/2.	Curcumin	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	82-85
29052798-7	2018	Taken together, our investigations demonstrated that curcumin pretreatment conferred BMSCs the ability to survive from H2O2-induced oxidative stress, which might attribute to its prevention of mitochondrial dysfunction and deactivation of Akt and Erk1/2 signaling pathways.	Curcumin	53-61	AKT serine/threonine kinase 1	Rattus norvegicus	239-242
29626566-0	2018	Antidepressant-like effects of a novel curcumin derivative J147: Involvement of 5-HT1A receptor.	Curcumin	39-47	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	80-95
29805641-10	2018	These results indicate that EGF-conjugated NHS-PEG10000-DSPE phospholipid NPs loaded with curcumin may be useful for treating TNBCs that overexpress the EGF receptor.	Curcumin	90-98	epidermal growth factor receptor	Homo sapiens	153-165
29582250-6	2018	Nonsteroidal anti-inflammatory drugs, curcumin, antipsychotic drugs, adiponectin, and sulforaphane downregulate the WNT/beta-catenin pathway through the upregulation of PPAR-gamma and thus appear to provide an interesting therapeutic approach for gliomas.	Curcumin	38-46	adiponectin, C1Q and collagen domain containing	Homo sapiens	69-80
29582250-6	2018	Nonsteroidal anti-inflammatory drugs, curcumin, antipsychotic drugs, adiponectin, and sulforaphane downregulate the WNT/beta-catenin pathway through the upregulation of PPAR-gamma and thus appear to provide an interesting therapeutic approach for gliomas.	Curcumin	38-46	peroxisome proliferator activated receptor gamma	Homo sapiens	169-179
29693159-0	2018	Effect of curcumin on the cell surface markers CD44 and CD24 in breast cancer.	Curcumin	10-18	CD24 molecule	Homo sapiens	56-60
29693159-4	2018	The aim of the present study was to investigate the effects of curcumin on the surface expression of CD44 and CD24 in breast epithelial cell lines.	Curcumin	63-71	CD24 molecule	Homo sapiens	110-114
29693159-6	2018	The results revealed that curcumin decreased CD44 and CD24 gene and protein expression levels in MCF-10F (normal), Alpha5 (premalignant) and Tumor2 (malignant) cell lines compared with the levels in their counterpart control cells.	Curcumin	26-34	CD24 molecule	Homo sapiens	54-58
29693159-8	2018	Curcumin increased CD44+/CD24+ to a greater extent and decreased CD44+/CD24- subpopulations in the normal MCF-10F and the pre-tumorigenic Alpha5 cells, but had no significant effect on Tumor2 cells compared with the corresponding control cells.	Curcumin	0-8	CD24 molecule	Homo sapiens	25-29
29693159-8	2018	Curcumin increased CD44+/CD24+ to a greater extent and decreased CD44+/CD24- subpopulations in the normal MCF-10F and the pre-tumorigenic Alpha5 cells, but had no significant effect on Tumor2 cells compared with the corresponding control cells.	Curcumin	0-8	CD24 molecule	Homo sapiens	71-75
29693159-9	2018	Conversely, curcumin increased CD44 and decreased CD24 gene expression in MCF-7 breast cancer cells, and decreased CD44 gene expression in MDA-MB-231 cell line, while CD24 was not present in these cells.	Curcumin	12-20	CD24 molecule	Homo sapiens	50-54
29693159-13	2018	In conclusion, these results indicated that curcumin may be used to improve the proportion of CD44+/CD24+ cells and decrease the proportion of CD44+/CD24- cells.	Curcumin	44-52	CD24 molecule	Homo sapiens	100-104
29693159-13	2018	In conclusion, these results indicated that curcumin may be used to improve the proportion of CD44+/CD24+ cells and decrease the proportion of CD44+/CD24- cells.	Curcumin	44-52	CD24 molecule	Homo sapiens	149-153
32185966-14	2018	Combination of Astragalus polysaccharide and Curcumin increased the expression of Bax and caspase-3, and decreased the expression of Bcl-2 to initiate apoptosis in A549 cells under chemical-induced hypoxia.	Curcumin	45-53	BCL2 associated X, apoptosis regulator	Homo sapiens	82-85
32185966-14	2018	Combination of Astragalus polysaccharide and Curcumin increased the expression of Bax and caspase-3, and decreased the expression of Bcl-2 to initiate apoptosis in A549 cells under chemical-induced hypoxia.	Curcumin	45-53	BCL2 apoptosis regulator	Homo sapiens	133-138
29614381-1	2018	A large body of biomedical evidence indicates that activation of Nrf2 by curcumin increases the nucleophilic tone and damps inflammation cumulatively supporting the malignant phenotype.	Curcumin	73-81	NFE2 like bZIP transcription factor 2	Homo sapiens	65-69
29570500-0	2018	Curcumin mitigates axonal injury and neuronal cell apoptosis through the PERK/Nrf2 signaling pathway following diffuse axonal injury.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	78-82
29887802-2	2018	In this study, we explored the potential of curcumin to prevent AFB1-induced liver injury by modulating liver phase-I and phase-II enzymes along with Nrf2 involved in AFB1 bioactivation and detoxification.	Curcumin	44-52	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
29887802-8	2018	Transcription factor Nrf2, its downstream genes such as GSTA3, and GSTM2 mRNA, and protein expression level significantly upregulated via dietary curcumin.	Curcumin	146-154	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
29887802-8	2018	Transcription factor Nrf2, its downstream genes such as GSTA3, and GSTM2 mRNA, and protein expression level significantly upregulated via dietary curcumin.	Curcumin	146-154	glutathione S-transferase alpha 3	Homo sapiens	56-61
29887802-9	2018	In addition, GSTs enzyme activity was enhanced with dietary curcumin which plays a crucial role in AFB1-detoxification.	Curcumin	60-68	glutathione S-transferase alpha 3	Homo sapiens	13-17
29844464-0	2018	Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1alpha inhibition.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	92-96
29844464-0	2018	Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1alpha inhibition.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-106
29844464-3	2018	Herein, we show that curcumin inhibits glucose uptake and lactate production (Warburg effect) in a variety of cancer cell lines by down-regulating PKM2 expression, via inhibition of mTOR-HIF1alpha axis.	Curcumin	21-29	mechanistic target of rapamycin kinase	Homo sapiens	182-186
29844464-3	2018	Herein, we show that curcumin inhibits glucose uptake and lactate production (Warburg effect) in a variety of cancer cell lines by down-regulating PKM2 expression, via inhibition of mTOR-HIF1alpha axis.	Curcumin	21-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	187-196
29801408-6	2018	Cell viability was significantly decreased in curcumin 17 muM, but not in curcumin8.5 muM group.	Curcumin	46-54	latexin	Homo sapiens	58-61
29801408-8	2018	Theresults showed that administration of curcumin in all the dose administered were incapable improving the expressionsof vimentin, TGF-beta1 and E-cadherin.	Curcumin	41-49	transforming growth factor beta 1	Homo sapiens	132-141
29801408-8	2018	Theresults showed that administration of curcumin in all the dose administered were incapable improving the expressionsof vimentin, TGF-beta1 and E-cadherin.	Curcumin	41-49	cadherin 1	Homo sapiens	146-156
29801408-9	2018	There was a decrease in ROS concentration in curcumin treated cells (8.5 muM)while in curcumin 17 muM, ROS concentration was increased.	Curcumin	45-53	latexin	Homo sapiens	73-76
29801408-9	2018	There was a decrease in ROS concentration in curcumin treated cells (8.5 muM)while in curcumin 17 muM, ROS concentration was increased.	Curcumin	86-94	latexin	Homo sapiens	98-101
29570500-4	2018	Moreover, curcumin is an activator of nuclear factor-erythroid 2-related factor 2 (Nrf2) and promotes its nuclear translocation.	Curcumin	10-18	NFE2 like bZIP transcription factor 2	Rattus norvegicus	38-81
29570500-4	2018	Moreover, curcumin is an activator of nuclear factor-erythroid 2-related factor 2 (Nrf2) and promotes its nuclear translocation.	Curcumin	10-18	NFE2 like bZIP transcription factor 2	Rattus norvegicus	83-87
29570500-8	2018	Further investigation showed that the protective effect of curcumin in DAI was mediated by the PERK/Nrf2 pathway.	Curcumin	59-67	NFE2 like bZIP transcription factor 2	Rattus norvegicus	100-104
29570500-9	2018	Curcumin promoted PERK phosphorylation, and then Nrf2 dissociated from Keap1 and was translocated to the nucleus, which activated ATF4, an important bZIP transcription factor that maintains intracellular homeostasis, but inhibited the CHOP, a hallmark of ER stress and ER-associated programmed cell death.	Curcumin	0-8	activating transcription factor 4	Rattus norvegicus	130-134
29570500-10	2018	In summary, we demonstrate for the first time that curcumin confers protection against abnormal proteins and neuronal apoptosis after DAI, that the process is mediated by strengthening of the unfolded protein response to overcome ER stress, and that the protective effect of curcumin against DAI is dependent on the activation of Nrf2.	Curcumin	275-283	NFE2 like bZIP transcription factor 2	Rattus norvegicus	330-334
29804421-0	2018	[Inhibitory effect of DAPT on Notch signaling pathway in curcumin mediated photodynamic therapy for cervical cancer xenografts in nude mice].	Curcumin	57-65	notch receptor 1	Homo sapiens	30-35
29804421-1	2018	Objective: Curcumin was used as photosensitizers in photodynamic therapy on cervical cancer xenografts in nude mice.Analysis the expression changes of Notch and downstream gene as NF-kappaB and VEGF before and after DAPT inhibition of Notch signaling pathway in vivo experiments.Our aim was to investigate the possible mechanism of Notch signaling pathway in the treatment of cervical cancer with PDT.	Curcumin	11-19	notch receptor 1	Homo sapiens	151-156
29804421-1	2018	Objective: Curcumin was used as photosensitizers in photodynamic therapy on cervical cancer xenografts in nude mice.Analysis the expression changes of Notch and downstream gene as NF-kappaB and VEGF before and after DAPT inhibition of Notch signaling pathway in vivo experiments.Our aim was to investigate the possible mechanism of Notch signaling pathway in the treatment of cervical cancer with PDT.	Curcumin	11-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	180-189
29804421-5	2018	Both DAPT and curcumin-PDT can inhibit the protein expression of Notch1, NF-kappaB and VEGF, and two of them have synergistic effect after combined use.	Curcumin	14-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-82
29804421-1	2018	Objective: Curcumin was used as photosensitizers in photodynamic therapy on cervical cancer xenografts in nude mice.Analysis the expression changes of Notch and downstream gene as NF-kappaB and VEGF before and after DAPT inhibition of Notch signaling pathway in vivo experiments.Our aim was to investigate the possible mechanism of Notch signaling pathway in the treatment of cervical cancer with PDT.	Curcumin	11-19	notch receptor 1	Homo sapiens	235-240
29804421-6	2018	Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy.	Curcumin	393-401	notch receptor 1	Homo sapiens	168-173
29804421-6	2018	Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy.	Curcumin	393-401	notch receptor 1	Homo sapiens	168-173
29804421-1	2018	Objective: Curcumin was used as photosensitizers in photodynamic therapy on cervical cancer xenografts in nude mice.Analysis the expression changes of Notch and downstream gene as NF-kappaB and VEGF before and after DAPT inhibition of Notch signaling pathway in vivo experiments.Our aim was to investigate the possible mechanism of Notch signaling pathway in the treatment of cervical cancer with PDT.	Curcumin	11-19	notch receptor 1	Homo sapiens	235-240
30966575-0	2018	Oral Delivery of Curcumin Polymeric Nanoparticles Ameliorates CCl4-Induced Subacute Hepatotoxicity in Wistar Rats.	Curcumin	17-25	C-C motif chemokine ligand 4	Rattus norvegicus	62-66
29766185-0	2018	The curcumin derivative WZ35 activates ROS-dependent JNK to suppress hepatocellular carcinoma metastasis.	Curcumin	4-12	mitogen-activated protein kinase 8	Homo sapiens	53-56
30966575-2	2018	In the present study, we report that curcumin nanoparticles (etaCur) protects Wistar rats against carbon tetrachloride (CCl4)-induced subacute hepatotoxicity.	Curcumin	37-45	C-C motif chemokine ligand 4	Rattus norvegicus	120-124
29664496-7	2018	2,6-Dimethyl-curcumin was more potent than curcumin in inhibiting NF-kappaB activity but less potent in inhibiting expression of cyclooxygenase-2 in LPS-activated RAW264.7 cells.	Curcumin	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75
29547900-8	2018	Among these genes, Tnf stood out with decreased DNA CpG methylation of Tnf in the AOM-DSS group and reversal of the AOM-DSS induced Tnf demethylation by curcumin.	Curcumin	153-161	tumor necrosis factor	Mus musculus	19-22
29547900-8	2018	Among these genes, Tnf stood out with decreased DNA CpG methylation of Tnf in the AOM-DSS group and reversal of the AOM-DSS induced Tnf demethylation by curcumin.	Curcumin	153-161	tumor necrosis factor	Mus musculus	71-74
29547900-8	2018	Among these genes, Tnf stood out with decreased DNA CpG methylation of Tnf in the AOM-DSS group and reversal of the AOM-DSS induced Tnf demethylation by curcumin.	Curcumin	153-161	tumor necrosis factor	Mus musculus	71-74
29471218-3	2018	Here, we present a study of LLN covered by the protein human serum albumin (HSA) and loaded with curcumin as a hydrophobic model drug.	Curcumin	97-105	albumin	Homo sapiens	61-74
29542686-7	2018	Instead, I comment on how curcumin and dietary polyphenol research has enriched our knowledge of insulin signaling, including the presentation of my perspectives on how these studies will add to our understanding of the famous hepatic insulin function paradox.	Curcumin	26-34	insulin	Homo sapiens	97-104
28992682-0	2018	Nanocurcumin-Mediated Down-Regulation of Telomerase Via Stimulating TGFbeta1 Signaling Pathway in Hepatocellular Carcinoma Cells Background: Curcumin, extracted from turmeric, represents enormous potential to serve as an anticancer agent.	Curcumin	141-149	transforming growth factor beta 1	Homo sapiens	68-76
29512729-0	2018	Curcumin inhibits superoxide dismutase-induced epithelial-to-mesenchymal transition via the PI3K/Akt/NF-kappaB pathway in pancreatic cancer cells.	Curcumin	0-8	superoxide dismutase 1	Homo sapiens	18-38
29512729-0	2018	Curcumin inhibits superoxide dismutase-induced epithelial-to-mesenchymal transition via the PI3K/Akt/NF-kappaB pathway in pancreatic cancer cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	97-100
29512729-0	2018	Curcumin inhibits superoxide dismutase-induced epithelial-to-mesenchymal transition via the PI3K/Akt/NF-kappaB pathway in pancreatic cancer cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	101-110
29938678-8	2018	Co-treatment with curcumin markedly reduced apoptosis and ROS production, together with increased MMP and Bcl2/Bax protein ratio.	Curcumin	18-26	BCL2, apoptosis regulator	Rattus norvegicus	106-110
29938678-9	2018	Inhibition of PI3K/Akt signaling pathway abolished protective effect of curcumin in MSG-induced toxicity in rat thymocytes.	Curcumin	72-80	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
29938678-10	2018	Obtained findings suggest that curcumin may attenuate the MSG-induced apoptosis through PI3K/Akt signaling pathway which could be useful in preventing the potential deficiencies in T cell-mediated immunity.	Curcumin	31-39	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
29512729-4	2018	However, whether curcumin suppresses SOD-induced cancer progression and the related mechanisms remains unclear.	Curcumin	17-25	superoxide dismutase 1	Homo sapiens	37-40
29485738-0	2018	Curcumin suppressed the prostate cancer by inhibiting JNK pathways via epigenetic regulation.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	54-57
29512729-5	2018	Since epithelial-to-mesenchymal transition (EMT) plays a key role in tumor metastasis, the aim of the present study was to examine whether curcumin intervenes with SOD-induced EMT in pancreatic cancer and the underlying mechanism.	Curcumin	139-147	superoxide dismutase 1	Homo sapiens	164-167
29512729-11	2018	The findings of the present study demonstrated that curcumin decreased SOD-induced production of ROS and H2O2 in BxPC-3 and Panc-1 cells.	Curcumin	52-60	superoxide dismutase 1	Homo sapiens	71-74
29512729-12	2018	Curcumin was able to suppress SOD-induced invasion and migration, and it also regulated the expression of the above-mentioned EMT-related genes and cell morphology.	Curcumin	0-8	superoxide dismutase 1	Homo sapiens	30-33
29512729-14	2018	Furthermore, the levels of p-Akt and p-NF-kappaB caused by SOD could be offset by treatment with curcumin and LY 294002.	Curcumin	97-105	AKT serine/threonine kinase 1	Homo sapiens	29-32
29512729-14	2018	Furthermore, the levels of p-Akt and p-NF-kappaB caused by SOD could be offset by treatment with curcumin and LY 294002.	Curcumin	97-105	nuclear factor kappa B subunit 1	Homo sapiens	39-48
29512729-14	2018	Furthermore, the levels of p-Akt and p-NF-kappaB caused by SOD could be offset by treatment with curcumin and LY 294002.	Curcumin	97-105	superoxide dismutase 1	Homo sapiens	59-62
29512729-15	2018	To summarize, these results demonstrated that curcumin was able to prevent SOD-driven H2O2-induced pancreatic cancer metastasis by blocking the PI3K/Akt/NF-kappaB signaling pathway.	Curcumin	46-54	superoxide dismutase 1	Homo sapiens	75-78
29512729-15	2018	To summarize, these results demonstrated that curcumin was able to prevent SOD-driven H2O2-induced pancreatic cancer metastasis by blocking the PI3K/Akt/NF-kappaB signaling pathway.	Curcumin	46-54	AKT serine/threonine kinase 1	Homo sapiens	149-152
29512729-15	2018	To summarize, these results demonstrated that curcumin was able to prevent SOD-driven H2O2-induced pancreatic cancer metastasis by blocking the PI3K/Akt/NF-kappaB signaling pathway.	Curcumin	46-54	nuclear factor kappa B subunit 1	Homo sapiens	153-162
29512729-16	2018	The use of curcumin to inhibit the H2O2/Akt/NF-kappaB axis may be a promising therapeutic approach to the treatment of patients with pancreatic cancer.	Curcumin	11-19	AKT serine/threonine kinase 1	Homo sapiens	40-43
29512729-16	2018	The use of curcumin to inhibit the H2O2/Akt/NF-kappaB axis may be a promising therapeutic approach to the treatment of patients with pancreatic cancer.	Curcumin	11-19	nuclear factor kappa B subunit 1	Homo sapiens	44-53
29485738-9	2018	Curcumin inhibited JNK pathway and repressed H3K4me3 in LNCaP cells.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	19-22
29485738-11	2018	In conclusion, curcumin inhibits JNK pathway and plays a role in epigenetic regulation of prostate cancer cells by repressing H3K4me3.	Curcumin	15-23	mitogen-activated protein kinase 8	Homo sapiens	33-36
28856444-6	2018	Curcumin downregulated Cdx-2 and Hif-1alpha mRNA expression and upregulated HO-1 and SOD 2, and these effects were reversed by L-NNA and further restored by co-treatment of L-NNA with L-arginine.	Curcumin	0-8	caudal type homeo box 2	Rattus norvegicus	23-28
29714206-7	2018	Curcumin treatment of PC12 cells was associated with increased expression of the NMDAR subunit, NR2A.	Curcumin	0-8	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	96-100
29714206-8	2018	CONCLUSIONS The findings of this study showed a neuroprotective effect of curcumin treatment in an in vitro model of Alzheimer"s disease that was associated with the increased expression of the NMDAR subunit, NR2A.	Curcumin	74-82	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	209-213
29686295-0	2018	Curcumin interacts directly with the Cysteine 259 residue of STAT3 and induces apoptosis in H-Ras transformed human mammary epithelial cells.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	61-66
29571711-0	2018	Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
29571711-10	2018	However, Nrf2 deletion attenuated the neuroprotective effects of curcumin in Nrf2-KO mice after TBI.	Curcumin	65-73	nuclear factor, erythroid derived 2, like 2	Mus musculus	9-13
29571711-10	2018	However, Nrf2 deletion attenuated the neuroprotective effects of curcumin in Nrf2-KO mice after TBI.	Curcumin	65-73	nuclear factor, erythroid derived 2, like 2	Mus musculus	77-81
29571711-11	2018	These findings demonstrated that curcumin effects on TBI are associated with the activation the Nrf2 pathway, providing novel insights into the neuroprotective role of Nrf2 and the potential therapeutic use of curcumin for TBI.	Curcumin	33-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-100
29571711-11	2018	These findings demonstrated that curcumin effects on TBI are associated with the activation the Nrf2 pathway, providing novel insights into the neuroprotective role of Nrf2 and the potential therapeutic use of curcumin for TBI.	Curcumin	33-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	168-172
29571711-11	2018	These findings demonstrated that curcumin effects on TBI are associated with the activation the Nrf2 pathway, providing novel insights into the neuroprotective role of Nrf2 and the potential therapeutic use of curcumin for TBI.	Curcumin	210-218	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-100
29700289-3	2018	In the present study, we demonstrated that FAK is implicated in RCP-induced EGFR phosphorylation and ovarian cancer cell invasion with inhibition by curcumin.	Curcumin	149-157	epidermal growth factor receptor	Homo sapiens	76-80
29700289-5	2018	Interestingly, we observed for the first time that curcumin attenuates RCP-induced ovarian cancer cell invasion by blocking stabilization of beta1 integrin and consequently inhibiting FAK and EGFR activation, providing potential biomarkers for ovarian cancer and therapeutic approaches for this deadly disease.	Curcumin	51-59	epidermal growth factor receptor	Homo sapiens	192-196
29686295-4	2018	In the present study, we have found that curcumin inhibits STAT3 signaling that is persistently overactivated in H-Ras transformed breast epithelial cells (H-Ras MCF10A).	Curcumin	41-49	signal transducer and activator of transcription 3	Homo sapiens	59-64
29686295-6	2018	We identified the cysteine residue 259 of STAT3 as a putative site for curcumin binding.	Curcumin	71-79	signal transducer and activator of transcription 3	Homo sapiens	42-47
29686295-7	2018	Site-directed mutation of this cysteine residue abolished curcumin-induced inactivation of STAT3 and apoptosis in H-Ras MCF10A cells.	Curcumin	58-66	signal transducer and activator of transcription 3	Homo sapiens	91-96
29686295-8	2018	The alpha,beta-unsaturated carbonyl moiety of curcumin appears to be essential in its binding to STAT3 in H-Ras MCF10A cells.	Curcumin	46-54	signal transducer and activator of transcription 3	Homo sapiens	97-102
29686295-10	2018	Taken together, our findings suggest that curcumin can abrogate aberrant activation of STAT3 through direct interaction, thereby inhibiting STAT3-mediated mammary carcinogenesis.	Curcumin	42-50	signal transducer and activator of transcription 3	Homo sapiens	87-92
29408622-0	2018	Inhibition of hepatocellular carcinoma tumorigenesis by curcumin may be associated with CDKN1A and CTGF.	Curcumin	56-64	cyclin dependent kinase inhibitor 1A	Homo sapiens	88-94
29686295-10	2018	Taken together, our findings suggest that curcumin can abrogate aberrant activation of STAT3 through direct interaction, thereby inhibiting STAT3-mediated mammary carcinogenesis.	Curcumin	42-50	signal transducer and activator of transcription 3	Homo sapiens	140-145
29408622-5	2018	Finally, we detected the expression of CDKN1A, CTGF, LEF1 TF and MIR-19A regulated by curcumin in PLC/PRF/5 cells using RT-PCR.	Curcumin	86-94	cyclin dependent kinase inhibitor 1A	Homo sapiens	39-45
27819521-3	2018	In this study, we found that expression of miR-326, a tumor suppressor microRNA in various tumor types, resulted in a marked increase of curcumin-induced cytotoxicity and apoptosis and a decrease of proliferation and migration in glioma cells.	Curcumin	137-145	microRNA 326	Homo sapiens	43-50
29408622-12	2018	Furthermore, the expression of CDKN1A, CTGF, LEF1 TF and miR-19A regulated by curcumin in PLC/PRF/5 cells was consistent with the aforementioned bioinformatics analysis results.	Curcumin	78-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	31-37
29408622-13	2018	To conclude, curcumin might exert its protective effects against HCC tumorigenesis by downregulating LEF1 and downregulating CTGF regulated by MIR-19A and upregulating CDKN1A expression.	Curcumin	13-21	cyclin dependent kinase inhibitor 1A	Homo sapiens	168-174
29657313-0	2018	Curcumin Attenuates Inflammation in a Severe Acute Pancreatitis Animal Model by Regulating TRAF1/ASK1 Signaling.	Curcumin	0-8	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	97-101
29657313-10	2018	RESULTS Pre-treatment with curcumin reduced the concentrations of interleukin (IL6) and tumor necrosis factor (TNFalpha) in serum and ascites, as well as the ascites volume and amylase activity in SAP rats.	Curcumin	27-35	interleukin 6	Rattus norvegicus	79-82
29657313-10	2018	RESULTS Pre-treatment with curcumin reduced the concentrations of interleukin (IL6) and tumor necrosis factor (TNFalpha) in serum and ascites, as well as the ascites volume and amylase activity in SAP rats.	Curcumin	27-35	tumor necrosis factor	Rattus norvegicus	111-119
29657313-11	2018	Pre-treatment with curcumin reduced the expression level of TNF receptor-associated factor 1 (TRAF1), IL6, and TNFa in pancreas in SAP rats.	Curcumin	19-27	interleukin 6	Rattus norvegicus	102-105
29657313-13	2018	The molecular association between ASK1 and Trx was recovered by curcumin pre-treatment.	Curcumin	64-72	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	34-38
29657313-13	2018	The molecular association between ASK1 and Trx was recovered by curcumin pre-treatment.	Curcumin	64-72	thioredoxin 1	Rattus norvegicus	43-46
29549176-0	2018	Curcumin Suppresses IL-1beta Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome.	Curcumin	0-8	interleukin 1 beta	Mus musculus	20-28
29549176-4	2018	We report that curcumin inhibited caspase-1 activation and IL-1beta secretion through suppressing LPS priming and the inflammasome activation pathway in mouse bone marrow-derived macrophages.	Curcumin	15-23	interleukin 1 beta	Mus musculus	59-67
29549176-8	2018	Importantly, in vivo data show that curcumin attenuated IL-1beta secretion and prevented high-fat diet-induced insulin resistance in wide-type C57BL/6 mice but not in Nlrp3-deficient mice.	Curcumin	36-44	interleukin 1 beta	Mus musculus	56-64
29731715-5	2018	Inflammatory cytokine tumor necrosis factor-alpha [TNF-alpha, prostaglandin E2 (PGE2), and Nitric Oxide (NO] secretion in LTA-induced microglial cells were inhibited by curcumin.	Curcumin	169-177	tumor necrosis factor	Mus musculus	22-49
29731715-6	2018	Curcumin also inhibited LTA-induced inducible NO synthases (iNOS) and cyclooxygenase-2 (COX-2) expression.	Curcumin	0-8	nitric oxide synthase 2, inducible	Mus musculus	60-64
29731715-7	2018	Subsequently, our mechanistic studies revealed that curcumin inhibited LTA-induced phosphorylation of mitogen-activated protein kinase (MAPK) including ERK, p38, Akt and translocation of NF-kappaB.	Curcumin	52-60	thymoma viral proto-oncogene 1	Mus musculus	162-165
29731715-7	2018	Subsequently, our mechanistic studies revealed that curcumin inhibited LTA-induced phosphorylation of mitogen-activated protein kinase (MAPK) including ERK, p38, Akt and translocation of NF-kappaB.	Curcumin	52-60	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	187-196
29731715-8	2018	Furthermore, curcumin induced hemeoxygenase (HO)-1HO-1 and nuclear factor erythroid 2-related factor 2 (Nrf-2) expression in microglial cells.	Curcumin	13-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-109
29566233-10	2018	Curcumin supplementation attenuated the depression of the thioredoxin 2 and peroxiredoxin-3 gene expressions (P &lt; 0.05).	Curcumin	0-8	thioredoxin 2	Gallus gallus	58-71
27819521-4	2018	Moreover, we found that combination treatment of miR-326 and curcumin caused significant inhibition of the SHH/GLI1 pathway in glioma cells compared with either treatment alone, independent of p53 status.	Curcumin	61-69	tumor protein p53	Homo sapiens	193-196
27819521-5	2018	Furthermore, in vivo, the curcumin-induced increase in miR-326 expression altered the anti-glioma mechanism of this combination treatment, which further reduced tumor volume and prolonged the survival period compared to either treatment alone.	Curcumin	26-34	microRNA 326	Homo sapiens	55-62
27819521-6	2018	Taken together, our data strongly support an important role for miR-326 in enhancing the chemosensitivity of glioma cells to curcumin.	Curcumin	125-133	microRNA 326	Homo sapiens	64-71
29369461-7	2018	Curcumin decreased the expression of steroidogenic acute regulatory proteins, CYP11A1 and HSD3B2 in prostate cancer cell lines, supporting the decrease of testosterone production.	Curcumin	0-8	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	78-85
29420338-9	2018	After curcumin treatment, drug-resistant cell proliferation was significantly inhibited; in the curcumin+irinotecan treatment group, E-cadherin expression was upregulated, whereas vimentin and N-cadherin expressions were downregulated.	Curcumin	6-14	cadherin 1	Homo sapiens	133-143
29420338-9	2018	After curcumin treatment, drug-resistant cell proliferation was significantly inhibited; in the curcumin+irinotecan treatment group, E-cadherin expression was upregulated, whereas vimentin and N-cadherin expressions were downregulated.	Curcumin	96-104	cadherin 1	Homo sapiens	133-143
29191105-2	2018	In this study, we examined the effect of curcumin on expression of drug-metabolizing enzymes through the AhR and NF-E2 related factor 2 (Nrf2) pathways.	Curcumin	41-49	NFE2 like bZIP transcription factor 2	Homo sapiens	113-135
29191105-2	2018	In this study, we examined the effect of curcumin on expression of drug-metabolizing enzymes through the AhR and NF-E2 related factor 2 (Nrf2) pathways.	Curcumin	41-49	NFE2 like bZIP transcription factor 2	Homo sapiens	137-141
29191105-3	2018	Curcumin dose-dependently inhibited TCDD-induced expression of phase I enzyme cytochrome P450 1A1 (CYP1A1) and phase II enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase 1 (HO-1) but not tert-butyl hydroquinone-induced NQO1 and HO-1, suggesting that curcumin inhibited only AhR pathway, but not Nrf2 one directly.	Curcumin	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	128-160
29191105-3	2018	Curcumin dose-dependently inhibited TCDD-induced expression of phase I enzyme cytochrome P450 1A1 (CYP1A1) and phase II enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase 1 (HO-1) but not tert-butyl hydroquinone-induced NQO1 and HO-1, suggesting that curcumin inhibited only AhR pathway, but not Nrf2 one directly.	Curcumin	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	162-166
29191105-3	2018	Curcumin dose-dependently inhibited TCDD-induced expression of phase I enzyme cytochrome P450 1A1 (CYP1A1) and phase II enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase 1 (HO-1) but not tert-butyl hydroquinone-induced NQO1 and HO-1, suggesting that curcumin inhibited only AhR pathway, but not Nrf2 one directly.	Curcumin	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	236-240
29191105-3	2018	Curcumin dose-dependently inhibited TCDD-induced expression of phase I enzyme cytochrome P450 1A1 (CYP1A1) and phase II enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase 1 (HO-1) but not tert-butyl hydroquinone-induced NQO1 and HO-1, suggesting that curcumin inhibited only AhR pathway, but not Nrf2 one directly.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	312-316
29369461-7	2018	Curcumin decreased the expression of steroidogenic acute regulatory proteins, CYP11A1 and HSD3B2 in prostate cancer cell lines, supporting the decrease of testosterone production.	Curcumin	0-8	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	Homo sapiens	90-96
29550706-7	2018	Surprisingly, similar trends were noted in mRNA, protein expression level of Nrf2 and its downstream genes at day 35, one week after the withdrawal of AFB1 and curcumin from the diet, showing the preventive effects of curcumin.	Curcumin	160-168	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
29044685-9	2018	PDTC and curcumin, which inhibits NF-kappaB signals, abolished CPA-induced nociceptive behaviour, referred hyperalgesia and, in part, increases in bladder weight.	Curcumin	9-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	34-43
29044685-12	2018	Therefore, NF-kappaB-inhibiting compounds including curcumin may be useful for the treatment of cystitis-related bladder pain.	Curcumin	52-60	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	11-20
29550706-7	2018	Surprisingly, similar trends were noted in mRNA, protein expression level of Nrf2 and its downstream genes at day 35, one week after the withdrawal of AFB1 and curcumin from the diet, showing the preventive effects of curcumin.	Curcumin	218-226	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
29545895-0	2018	Curcumin inhibits the growth of liver cancer stem cells through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	115-144
29545895-5	2018	The results of the study demonstrated that curcumin treatment inhibited the growth of LCSCs, induced cell apoptosis, as well as regulated the expression of apoptosis-associated proteins and the release of cytochrome c.	Curcumin	43-51	cytochrome c, somatic	Homo sapiens	205-217
29545895-6	2018	Further experiments revealed that treatment with curcumin inhibited that the activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway.	Curcumin	49-57	AKT serine/threonine kinase 1	Homo sapiens	150-153
29545895-6	2018	Further experiments revealed that treatment with curcumin inhibited that the activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway.	Curcumin	49-57	mechanistic target of rapamycin kinase	Homo sapiens	155-184
29545895-6	2018	Further experiments revealed that treatment with curcumin inhibited that the activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway.	Curcumin	49-57	mechanistic target of rapamycin kinase	Homo sapiens	186-190
29545895-7	2018	Treatment with an activator of PI3K/AKT reversed the curcumin-induced growth inhibition of LCSCs.	Curcumin	53-61	AKT serine/threonine kinase 1	Homo sapiens	36-39
29545895-8	2018	These results demonstrated that curcumin inhibited the growth of LCSCs through the PI3K/AKT/mTOR signaling pathway.	Curcumin	32-40	AKT serine/threonine kinase 1	Homo sapiens	88-91
29545895-8	2018	These results demonstrated that curcumin inhibited the growth of LCSCs through the PI3K/AKT/mTOR signaling pathway.	Curcumin	32-40	mechanistic target of rapamycin kinase	Homo sapiens	92-96
29027056-8	2018	Curcumin supplementation prevented the LPS-induced upregulation in the protein activity of transcription factor NFkappaB, proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-1alpha), inducible nitric oxide synthase (iNOS) as well as the regulating molecules of the intrinsic apoptotic pathway (Bax, Bcl-2, Caspase 3 and Caspase 9) by ELISA.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	149-158
29027056-8	2018	Curcumin supplementation prevented the LPS-induced upregulation in the protein activity of transcription factor NFkappaB, proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-1alpha), inducible nitric oxide synthase (iNOS) as well as the regulating molecules of the intrinsic apoptotic pathway (Bax, Bcl-2, Caspase 3 and Caspase 9) by ELISA.	Curcumin	0-8	interleukin 1 alpha	Rattus norvegicus	160-168
29027056-8	2018	Curcumin supplementation prevented the LPS-induced upregulation in the protein activity of transcription factor NFkappaB, proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-1alpha), inducible nitric oxide synthase (iNOS) as well as the regulating molecules of the intrinsic apoptotic pathway (Bax, Bcl-2, Caspase 3 and Caspase 9) by ELISA.	Curcumin	0-8	interleukin 1 alpha	Rattus norvegicus	174-183
29027056-8	2018	Curcumin supplementation prevented the LPS-induced upregulation in the protein activity of transcription factor NFkappaB, proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-1alpha), inducible nitric oxide synthase (iNOS) as well as the regulating molecules of the intrinsic apoptotic pathway (Bax, Bcl-2, Caspase 3 and Caspase 9) by ELISA.	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	186-217
29027056-8	2018	Curcumin supplementation prevented the LPS-induced upregulation in the protein activity of transcription factor NFkappaB, proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-1alpha), inducible nitric oxide synthase (iNOS) as well as the regulating molecules of the intrinsic apoptotic pathway (Bax, Bcl-2, Caspase 3 and Caspase 9) by ELISA.	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	219-223
29027056-8	2018	Curcumin supplementation prevented the LPS-induced upregulation in the protein activity of transcription factor NFkappaB, proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-1alpha), inducible nitric oxide synthase (iNOS) as well as the regulating molecules of the intrinsic apoptotic pathway (Bax, Bcl-2, Caspase 3 and Caspase 9) by ELISA.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	302-307
29027056-8	2018	Curcumin supplementation prevented the LPS-induced upregulation in the protein activity of transcription factor NFkappaB, proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-1alpha), inducible nitric oxide synthase (iNOS) as well as the regulating molecules of the intrinsic apoptotic pathway (Bax, Bcl-2, Caspase 3 and Caspase 9) by ELISA.	Curcumin	0-8	caspase 9	Rattus norvegicus	323-332
29437881-7	2018	In addition, curcumin treatment after d-gal administration resulted in significantly lower Sod2, Cat, 8-OhdG, 4-HNE, NTY and senescence-associated protein P16 expression levels, higher Amh expression levels and less apoptosis in granulosa cells than was observed in the d-gal group.	Curcumin	13-21	superoxide dismutase 2, mitochondrial	Mus musculus	91-95
29437881-7	2018	In addition, curcumin treatment after d-gal administration resulted in significantly lower Sod2, Cat, 8-OhdG, 4-HNE, NTY and senescence-associated protein P16 expression levels, higher Amh expression levels and less apoptosis in granulosa cells than was observed in the d-gal group.	Curcumin	13-21	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	155-158
29437881-8	2018	Moreover, the p-Akt, Nrf2 and HO-1 protein expression levels were significantly higher and the apoptosis-related cleaved caspase-3 and -9 protein expression levels were markedly lower in the curcumin group than in the d-gal group.	Curcumin	191-199	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
29437881-8	2018	Moreover, the p-Akt, Nrf2 and HO-1 protein expression levels were significantly higher and the apoptosis-related cleaved caspase-3 and -9 protein expression levels were markedly lower in the curcumin group than in the d-gal group.	Curcumin	191-199	heme oxygenase 1	Mus musculus	30-34
29437881-9	2018	In conclusion, curcumin effectively inhibited d-gal-induced oxidative stress, apoptosis and ovarian injury via a mechanism involving the Nrf2/HO-1 and PI3K/Akt signaling pathways, suggesting that curcumin is a potential protective agent against POF.	Curcumin	15-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	137-141
29437881-9	2018	In conclusion, curcumin effectively inhibited d-gal-induced oxidative stress, apoptosis and ovarian injury via a mechanism involving the Nrf2/HO-1 and PI3K/Akt signaling pathways, suggesting that curcumin is a potential protective agent against POF.	Curcumin	15-23	heme oxygenase 1	Mus musculus	142-146
29552196-0	2018	Curcumin may serve an anticancer role in human osteosarcoma cell line U-2 OS by targeting ITPR1.	Curcumin	0-8	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	90-95
29242172-3	2018	In this study, we have investigated whether curcumin regulates metabolic changes in cholesterol metabolism via LXRalpha in THP-1 human macrophages, the cells implicated in atheroma plaques formation.	Curcumin	44-52	GLI family zinc finger 2	Homo sapiens	123-128
29242172-5	2018	Curcumin up-regulated mRNA expression of genes involved in cholesterol transport and metabolism as ATP-binding cassette (ABC) transporters ABCA1 and ABCG1, and the sterol response element binding protein 1c (SREBP1c).	Curcumin	0-8	ATP binding cassette subfamily G member 1	Homo sapiens	149-154
29242172-7	2018	Curcumin treatment inhibited cell migration and was also able to promote reverse cholesterol transport in THP-1 cells.	Curcumin	0-8	GLI family zinc finger 2	Homo sapiens	106-111
29436680-13	2018	Furthermore, the nuclear factor, erythroid 2 like 2 (Nrf2) expression in the nucleus was dose-dependently increased by curcumin.	Curcumin	119-127	NFE2 like bZIP transcription factor 2	Homo sapiens	17-51
29436680-13	2018	Furthermore, the nuclear factor, erythroid 2 like 2 (Nrf2) expression in the nucleus was dose-dependently increased by curcumin.	Curcumin	119-127	NFE2 like bZIP transcription factor 2	Homo sapiens	53-57
29436680-14	2018	Nrf2 siRNA successfully inhibited the curcumin-induced HO-1 expression.	Curcumin	38-46	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
29436680-15	2018	Curcumin significantly increased Nrf2-driven luciferase activity.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
29436680-16	2018	Overall, these data indicated that curcumin activates the Nrf2-ARE signaling pathway and upregulates HO-1 expression, which mediates SR-BI and ABCA1 expression and thereby increases cholesterol efflux.	Curcumin	35-43	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
29460119-0	2018	Curcumin Inhibits Monocyte Chemoattractant Protein-1 Expression in TNF-alpha induced Astrocytes Through AMPK Pathway.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	67-76
29460119-3	2018	Specifically, we investigated the inhibitory effect of Curcumin on tumor necrosis factor-alpha (TNF-alpha)-induced astrocyte migration.	Curcumin	55-63	tumor necrosis factor	Homo sapiens	96-105
29460119-6	2018	Our data demonstrated that Curcumin inhibited TNF-alpha-induced astrocytes migration, decreased MCP-1 expression, and up-regulated SOD2 expression in TNF-alpha-induced astrocytes in vitro.	Curcumin	27-35	tumor necrosis factor	Homo sapiens	46-55
29460119-6	2018	Our data demonstrated that Curcumin inhibited TNF-alpha-induced astrocytes migration, decreased MCP-1 expression, and up-regulated SOD2 expression in TNF-alpha-induced astrocytes in vitro.	Curcumin	27-35	tumor necrosis factor	Homo sapiens	150-159
29552196-12	2018	Targeting ITPR1 via curcumin may serve an anticancer role by mediating apoptosis, proliferation, migration and invasion in U-2 OS cells.	Curcumin	20-28	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	10-15
29552196-10	2018	RT-qPCR demonstrated that treatment with curcumin was able to significantly increase the levels of CLTC and ITPR1 mRNA in curcumin-treated cells compared with control.	Curcumin	41-49	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	108-113
29552196-10	2018	RT-qPCR demonstrated that treatment with curcumin was able to significantly increase the levels of CLTC and ITPR1 mRNA in curcumin-treated cells compared with control.	Curcumin	122-130	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	108-113
29552196-11	2018	In addition, targeting ITPR1 with curcumin significantly promoted apoptosis and suppressed proliferation, migration and invasion.	Curcumin	34-42	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	23-28
29089337-3	2018	Thus, a number of preclinical and clinical investigations have shown the beneficial effect of curcumin (and other dietary polyphenols) in attenuating body weight gain, improving insulin sensitivity, and preventing diabetes development in rodent models and prediabetic subjects.	Curcumin	94-102	insulin	Homo sapiens	178-185
29369435-6	2018	This concept is first demonstrated without drugs, and is further improved with the suitable loading of hydrophobic drugs, curcumin (CUR) and camptothecin (CPT), which are retained between the CNTs and human serum albumin (HSA) layer.	Curcumin	122-130	albumin	Homo sapiens	207-220
29552121-9	2018	Furthermore, curcumin treatment significantly decreased VEGF expression and PI3K/AKT signaling.	Curcumin	13-21	thymoma viral proto-oncogene 1	Mus musculus	81-84
29382728-0	2018	The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.	Curcumin	4-12	tumor protein p53	Homo sapiens	80-83
29382728-0	2018	The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.	Curcumin	4-12	tumor protein p53	Homo sapiens	129-132
29382728-5	2018	Here, we report on the effects of a curcumin analog, HO-3867, on p53 activity in cancer cells from different origins.	Curcumin	36-44	tumor protein p53	Homo sapiens	65-68
29541866-0	2018	Transferrin-Modified Vitamin-E/Lipid Based Polymeric Micelles for Improved Tumor Targeting and Anticancer Effect of Curcumin.	Curcumin	116-124	transferrin	Homo sapiens	0-11
29139094-13	2018	CONCLUSION: Curcumin might have therapeutic potential in breast cancer through regulating breast cancer-related genes, including SERPINE1, PGAP3, MAP3K1, MAPK1, GSTO2, VIM, SPARC, and FGF2.	Curcumin	12-20	mitogen-activated protein kinase 1	Homo sapiens	154-159
29353208-9	2018	Lower expression of SREBP-1c, pERK, TNF-alpha, and pJNK were also observed in berberine + curcumin group.	Curcumin	90-98	tumor necrosis factor	Rattus norvegicus	36-45
29325994-0	2018	The effects of melatonin and curcumin on the expression of SIRT2, Bcl-2 and Bax in the hippocampus of adult rats.	Curcumin	29-37	BCL2, apoptosis regulator	Rattus norvegicus	66-71
29599831-8	2018	Additionally, curcumin significantly inhibited the expression of p-Akt, p-Erk1/2, HIF-1alpha and VEGF in hypoxia-induced IGF-1R knockout HepG2 cells.	Curcumin	14-22	AKT serine/threonine kinase 1	Homo sapiens	67-70
29599831-8	2018	Additionally, curcumin significantly inhibited the expression of p-Akt, p-Erk1/2, HIF-1alpha and VEGF in hypoxia-induced IGF-1R knockout HepG2 cells.	Curcumin	14-22	mitogen-activated protein kinase 3	Homo sapiens	74-80
29599831-8	2018	Additionally, curcumin significantly inhibited the expression of p-Akt, p-Erk1/2, HIF-1alpha and VEGF in hypoxia-induced IGF-1R knockout HepG2 cells.	Curcumin	14-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-92
29599831-8	2018	Additionally, curcumin significantly inhibited the expression of p-Akt, p-Erk1/2, HIF-1alpha and VEGF in hypoxia-induced IGF-1R knockout HepG2 cells.	Curcumin	14-22	vascular endothelial growth factor A	Homo sapiens	97-101
29599831-0	2018	Effect of curcumin on vascular endothelial growth factor in hypoxic HepG2 cells via the insulin-like growth factor 1 receptor signaling pathway.	Curcumin	10-18	vascular endothelial growth factor A	Homo sapiens	22-56
29139094-13	2018	CONCLUSION: Curcumin might have therapeutic potential in breast cancer through regulating breast cancer-related genes, including SERPINE1, PGAP3, MAP3K1, MAPK1, GSTO2, VIM, SPARC, and FGF2.	Curcumin	12-20	fibroblast growth factor 2	Homo sapiens	184-188
29405636-9	2018	Finally, the in vivo and in vitro investigations suggested that curcumin increased expression of uncoupling protein 1 (UCP1), possibly involving PPAR-dependent and -independent mechanisms.	Curcumin	64-72	peroxisome proliferator activated receptor alpha	Mus musculus	145-149
29328421-11	2018	It is worth noting that the inhibition of mTOR by rapamycin or of PI3K/Akt by LY294002 augmented curcumin-induced apoptosis and autophagy, leading to significant inhibition of cell proliferation.	Curcumin	97-105	mechanistic target of rapamycin kinase	Homo sapiens	42-46
29328421-11	2018	It is worth noting that the inhibition of mTOR by rapamycin or of PI3K/Akt by LY294002 augmented curcumin-induced apoptosis and autophagy, leading to significant inhibition of cell proliferation.	Curcumin	97-105	AKT serine/threonine kinase 1	Homo sapiens	71-74
29328421-12	2018	From these findings, it can be speculated that curcumin potently inhibit the cell growth of NSCLC A549 cells through inducing both apoptosis and autophagy by inhibition of the PI3K/Akt/mTOR pathway.	Curcumin	47-55	AKT serine/threonine kinase 1	Homo sapiens	181-184
29328421-12	2018	From these findings, it can be speculated that curcumin potently inhibit the cell growth of NSCLC A549 cells through inducing both apoptosis and autophagy by inhibition of the PI3K/Akt/mTOR pathway.	Curcumin	47-55	mechanistic target of rapamycin kinase	Homo sapiens	185-189
29629345-6	2018	Results: Administration of curcumin significantly attenuated the severity of DSS-induced colitis and the activation of NF-kappaB and STAT3 as well as expression of COX-2 and inducible nitric oxide synthase.	Curcumin	27-35	signal transducer and activator of transcription 3	Mus musculus	133-138
29629345-6	2018	Results: Administration of curcumin significantly attenuated the severity of DSS-induced colitis and the activation of NF-kappaB and STAT3 as well as expression of COX-2 and inducible nitric oxide synthase.	Curcumin	27-35	nitric oxide synthase 2, inducible	Mus musculus	174-205
29629345-8	2018	Conclusions: Intragastric administration of curcumin inhibited the experimentally induced murine colitis, which was associated with inhibition of pro-inflammatory signaling mediated by NF-kappaB and STAT3.	Curcumin	44-52	signal transducer and activator of transcription 3	Mus musculus	199-204
29328421-0	2018	Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway.	Curcumin	22-30	AKT serine/threonine kinase 1	Homo sapiens	128-131
29328421-0	2018	Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway.	Curcumin	22-30	mechanistic target of rapamycin kinase	Homo sapiens	132-136
29328421-2	2018	In the present study, the effects of curcumin-induced multiple PCDs on human non-small cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co-culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002.	Curcumin	37-45	AKT serine/threonine kinase 1	Homo sapiens	219-222
29328421-2	2018	In the present study, the effects of curcumin-induced multiple PCDs on human non-small cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co-culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002.	Curcumin	37-45	mechanistic target of rapamycin kinase	Homo sapiens	223-227
29328421-2	2018	In the present study, the effects of curcumin-induced multiple PCDs on human non-small cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co-culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002.	Curcumin	37-45	mechanistic target of rapamycin kinase	Homo sapiens	310-314
29328421-2	2018	In the present study, the effects of curcumin-induced multiple PCDs on human non-small cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co-culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002.	Curcumin	37-45	AKT serine/threonine kinase 1	Homo sapiens	342-345
29328421-2	2018	In the present study, the effects of curcumin-induced multiple PCDs on human non-small cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co-culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002.	Curcumin	197-205	AKT serine/threonine kinase 1	Homo sapiens	219-222
29328421-2	2018	In the present study, the effects of curcumin-induced multiple PCDs on human non-small cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co-culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002.	Curcumin	197-205	mechanistic target of rapamycin kinase	Homo sapiens	223-227
29328421-2	2018	In the present study, the effects of curcumin-induced multiple PCDs on human non-small cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co-culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002.	Curcumin	197-205	mechanistic target of rapamycin kinase	Homo sapiens	310-314
29328421-2	2018	In the present study, the effects of curcumin-induced multiple PCDs on human non-small cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co-culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002.	Curcumin	197-205	AKT serine/threonine kinase 1	Homo sapiens	342-345
29328421-2	2018	In the present study, the effects of curcumin-induced multiple PCDs on human non-small cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co-culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002.	Curcumin	197-205	AKT serine/threonine kinase 1	Homo sapiens	219-222
29328421-2	2018	In the present study, the effects of curcumin-induced multiple PCDs on human non-small cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co-culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002.	Curcumin	197-205	mechanistic target of rapamycin kinase	Homo sapiens	223-227
29328421-2	2018	In the present study, the effects of curcumin-induced multiple PCDs on human non-small cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co-culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002.	Curcumin	197-205	mechanistic target of rapamycin kinase	Homo sapiens	310-314
29328421-2	2018	In the present study, the effects of curcumin-induced multiple PCDs on human non-small cell lung cancer (NSCLC) cells and the potential molecular mechanisms of apoptosis and autophagy triggered by curcumin via the PI3K/Akt/mTOR signaling pathway were explored, further confirmed by co-culture of curcumin with mTOR blocker rapamycin and PI3K/Akt inhibitor LY294002.	Curcumin	197-205	AKT serine/threonine kinase 1	Homo sapiens	342-345
29328421-10	2018	Furthermore, the effect of curcumin on a substantial downregulation of phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway was observed.	Curcumin	27-35	AKT serine/threonine kinase 1	Homo sapiens	108-111
29328421-10	2018	Furthermore, the effect of curcumin on a substantial downregulation of phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway was observed.	Curcumin	27-35	mechanistic target of rapamycin kinase	Homo sapiens	112-141
29328421-10	2018	Furthermore, the effect of curcumin on a substantial downregulation of phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway was observed.	Curcumin	27-35	mechanistic target of rapamycin kinase	Homo sapiens	143-147
29480285-10	2018	Elevated levels of HMGB1, RAGE, TNFalpha, IL6, and TGFbeta1 in both lung tissue and BALF from neonatal ALI rats were decreased dramatically by curcumin treatment.	Curcumin	143-151	advanced glycosylation end product-specific receptor	Rattus norvegicus	26-30
29193350-9	2018	Curcumin nanomicelle supplementation also resulted in a statistically significant improvement in plasma levels of total antioxidant capacity, malondialdehyde, C-reactive protein, and tumor necrosis factor a in comparison to the placebo.	Curcumin	0-8	C-reactive protein	Homo sapiens	159-177
29223572-0	2018	Curcumin ameliorates the in vitro efficacy of carfilzomib in human multiple myeloma U266 cells targeting p53 and NF-kappaB pathways.	Curcumin	0-8	tumor protein p53	Homo sapiens	105-108
29223572-8	2018	Our results confirmed the induction of p53/p21 axis and G0/G1 cell cycle arrest in anticancer activities of both drugs, an effect more pronounced for the CFZ-curcumin tested combinations.	Curcumin	158-166	tumor protein p53	Homo sapiens	39-42
29673545-0	2018	Curcumin induces apoptosis and cell cycle arrest via the activation of reactive oxygen species-independent mitochondrial apoptotic pathway in Smad4 and p53 mutated colon adenocarcinoma HT29 cells.	Curcumin	0-8	tumor protein p53	Homo sapiens	152-155
29673545-12	2018	In conclusion, our data provide the first evidence that curcumin induces ROS independent apoptosis and cell cycle arrest in colon cancer cells that carry mutation on Smad4 and p53.	Curcumin	56-64	tumor protein p53	Homo sapiens	176-179
29480285-10	2018	Elevated levels of HMGB1, RAGE, TNFalpha, IL6, and TGFbeta1 in both lung tissue and BALF from neonatal ALI rats were decreased dramatically by curcumin treatment.	Curcumin	143-151	tumor necrosis factor	Rattus norvegicus	32-40
29480285-10	2018	Elevated levels of HMGB1, RAGE, TNFalpha, IL6, and TGFbeta1 in both lung tissue and BALF from neonatal ALI rats were decreased dramatically by curcumin treatment.	Curcumin	143-151	interleukin 6	Rattus norvegicus	42-45
29480285-10	2018	Elevated levels of HMGB1, RAGE, TNFalpha, IL6, and TGFbeta1 in both lung tissue and BALF from neonatal ALI rats were decreased dramatically by curcumin treatment.	Curcumin	143-151	transforming growth factor, beta 1	Rattus norvegicus	51-59
29480285-12	2018	CONCLUSIONS Curcumin alleviated lung edema in LPS-induced ALI by inhibiting inflammation which was induced by PPARgamma/HO1 regulated-HMGB1/RAGE pro-inflammatory pathway.	Curcumin	12-20	advanced glycosylation end product-specific receptor	Rattus norvegicus	140-144
29228771-0	2018	Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	47-51
29353037-2	2018	Post oxygen and glucose deprivation/reoxygenation (OGD/R), primary mouse cortical neurons treated with curcumin exhibited a significant decrease in cell death, LDH release and enzyme caspase-3 activity under OGD/R circumstances, which were abolished by flotillin-1 downregulation or extracellular signal-regulated kinase (ERK) inhibitor.	Curcumin	103-111	mitogen-activated protein kinase 1	Mus musculus	283-320
29228771-8	2018	Compared with curcumin and SFN, F10 is more potent in activating Nrf2-ARE pathways.	Curcumin	14-22	nuclear factor, erythroid derived 2, like 2	Mus musculus	65-69
29454324-8	2018	The expression levels of HSP70 and the activities of 8-OHdG and MDA in the curcumin group were decreased compared with those in the model group, whereas the activities of CAT, SOD, and GSH-Px were significantly higher than those in the model group (P &lt; 0.05).	Curcumin	75-83	catalase	Rattus norvegicus	171-174
29065834-0	2018	Polymeric Nano-Encapsulation of Curcumin Enhances its Anti-Cancer Activity in Breast (MDA-MB231) and Lung (A549) Cancer Cells Through Reduction in Expression of HIF-1alpha and Nuclear p65 (Rel A).	Curcumin	32-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	161-171
29065834-1	2018	BACKGROUND: The anti-cancer potential of curcumin, a natural NFkappabeta inhibitor, has been reported extensively in breast, lung and other cancers.	Curcumin	41-49	nuclear factor kappa B subunit 1	Homo sapiens	61-72
29065834-9	2018	CONCLUSION: Our findings indicate that curcumin can effectively lower the elevated levels of HIF-1alpha and nuclear p65 (Rel A) in breast and lung cancer cells under an hypoxic tumour micro-environment when delivered in nanoparticulate form.	Curcumin	39-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	93-103
29440765-8	2018	In addition to baicalin treatment, we found that the hypoxia-response protein DEPP functions as a positive regulator involving the regulations of Ras/Raf/MEK/ERK signaling pathway and inhibition of human colon cancer by other anti-oxidative drugs, such as curcumin and sulforaphane, resulting in tumor cellular senescence.	Curcumin	256-264	mitogen-activated protein kinase kinase 7	Homo sapiens	154-157
29440765-8	2018	In addition to baicalin treatment, we found that the hypoxia-response protein DEPP functions as a positive regulator involving the regulations of Ras/Raf/MEK/ERK signaling pathway and inhibition of human colon cancer by other anti-oxidative drugs, such as curcumin and sulforaphane, resulting in tumor cellular senescence.	Curcumin	256-264	mitogen-activated protein kinase 1	Homo sapiens	158-161
29445279-0	2018	EGFR-targeted photodynamic therapy by curcumin-encapsulated chitosan/TPP nanoparticles.	Curcumin	38-46	epidermal growth factor receptor	Homo sapiens	0-4
29445279-8	2018	Conclusion: These curcumin-encapsulated chitosan/TPP nanoparticles are a promising targeted-PDT against EGFR-overexpressing cancers.	Curcumin	18-26	epidermal growth factor receptor	Homo sapiens	104-108
29322144-6	2018	For 60 days at 40  C storage, the antioxidant activity of curcumin measured by ABTS and FRAP assays was preserved with a percentage of 82 +- 2.0% and 84 +- 1.1%, respectively.	Curcumin	58-66	mechanistic target of rapamycin kinase	Homo sapiens	88-92
29618945-5	2018	We herein describe in vitro and in vivo effects of fifteen Nrf2-interacting natural compounds (tocotrienols, curcumin, epigallocatechin gallate, quercetin, genistein, resveratrol, silybin, phenethyl isothiocyanate, sulforaphane, triptolide, allicin, berberine, piperlongumine, fisetin, and phloretin) on cellular senescence and discuss their use in adjuvant cancer therapy.	Curcumin	109-117	NFE2 like bZIP transcription factor 2	Homo sapiens	59-63
29445415-0	2018	Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1beta.	Curcumin	0-8	interleukin 1 beta	Mus musculus	101-118
29353037-2	2018	Post oxygen and glucose deprivation/reoxygenation (OGD/R), primary mouse cortical neurons treated with curcumin exhibited a significant decrease in cell death, LDH release and enzyme caspase-3 activity under OGD/R circumstances, which were abolished by flotillin-1 downregulation or extracellular signal-regulated kinase (ERK) inhibitor.	Curcumin	103-111	mitogen-activated protein kinase 1	Mus musculus	322-325
29353037-3	2018	Moreover, flotillin-1 knockdown led to suppression of curcumin-mediated ERK phosphorylation under OGD/R condition.	Curcumin	54-62	mitogen-activated protein kinase 1	Mus musculus	72-75
29401702-4	2018	DHA and curcumin induce the expression of LCE3A/LCE3D/LCE3E mRNAs at concentrations corresponding to their affinity for VDR.	Curcumin	8-16	late cornified envelope 3E	Homo sapiens	54-59
29456509-0	2018	Curcumin Inhibits Growth of Human NCI-H292 Lung Squamous Cell Carcinoma Cells by Increasing FOXA2 Expression.	Curcumin	0-8	forkhead box A2	Homo sapiens	92-97
28915469-2	2018	To circumvent the detracting feature, two novel water-soluble amino acid modified curcumin derivatives (MLC and DLC) have been synthesized through the condensation reaction between curcumin and Nalpha-Fmoc-Nepsilon-Boc-l-lysine.	Curcumin	82-90	modulator of VRAC current 1	Homo sapiens	104-107
28915469-2	2018	To circumvent the detracting feature, two novel water-soluble amino acid modified curcumin derivatives (MLC and DLC) have been synthesized through the condensation reaction between curcumin and Nalpha-Fmoc-Nepsilon-Boc-l-lysine.	Curcumin	181-189	modulator of VRAC current 1	Homo sapiens	104-107
29401702-5	2018	Moreover, immunohistochemical quantitation revealed that the treatment of keratinocytes with DHA or curcumin stimulates LCE3 protein expression, while simultaneously opposing the tumor necrosis factor-alpha (TNFalpha)-signaled phosphorylation of mitogen activated protein (MAP) kinases, p38 and Jun amino-terminal kinase (JNK), thereby overcoming inflammation biomarkers elicited by TNFalpha challenge.	Curcumin	100-108	tumor necrosis factor	Homo sapiens	179-206
29456509-4	2018	Curcumin treatment inhibited NCI-H292 cell growth and increased FOXA2 expression in a time-dependent manner.	Curcumin	0-8	forkhead box A2	Homo sapiens	64-69
29456509-6	2018	Inhibition of cell proliferation by curcumin was attenuated by FOXA2 knockdown.	Curcumin	36-44	forkhead box A2	Homo sapiens	63-68
29401702-5	2018	Moreover, immunohistochemical quantitation revealed that the treatment of keratinocytes with DHA or curcumin stimulates LCE3 protein expression, while simultaneously opposing the tumor necrosis factor-alpha (TNFalpha)-signaled phosphorylation of mitogen activated protein (MAP) kinases, p38 and Jun amino-terminal kinase (JNK), thereby overcoming inflammation biomarkers elicited by TNFalpha challenge.	Curcumin	100-108	tumor necrosis factor	Homo sapiens	208-216
29456509-7	2018	Moreover inhibition of STAT3 pathways by curcumin increased FOXA2 expression in NCI-H292 cells whereas a STAT3 activator (IL-6) significantly inhibited curcumin-induced FOXA2 expression.	Curcumin	41-49	signal transducer and activator of transcription 3	Homo sapiens	23-28
29456509-7	2018	Moreover inhibition of STAT3 pathways by curcumin increased FOXA2 expression in NCI-H292 cells whereas a STAT3 activator (IL-6) significantly inhibited curcumin-induced FOXA2 expression.	Curcumin	41-49	forkhead box A2	Homo sapiens	60-65
29401702-5	2018	Moreover, immunohistochemical quantitation revealed that the treatment of keratinocytes with DHA or curcumin stimulates LCE3 protein expression, while simultaneously opposing the tumor necrosis factor-alpha (TNFalpha)-signaled phosphorylation of mitogen activated protein (MAP) kinases, p38 and Jun amino-terminal kinase (JNK), thereby overcoming inflammation biomarkers elicited by TNFalpha challenge.	Curcumin	100-108	mitogen-activated protein kinase 14	Homo sapiens	287-290
29456509-7	2018	Moreover inhibition of STAT3 pathways by curcumin increased FOXA2 expression in NCI-H292 cells whereas a STAT3 activator (IL-6) significantly inhibited curcumin-induced FOXA2 expression.	Curcumin	152-160	signal transducer and activator of transcription 3	Homo sapiens	105-110
29456509-7	2018	Moreover inhibition of STAT3 pathways by curcumin increased FOXA2 expression in NCI-H292 cells whereas a STAT3 activator (IL-6) significantly inhibited curcumin-induced FOXA2 expression.	Curcumin	152-160	interleukin 6	Homo sapiens	122-126
29401702-5	2018	Moreover, immunohistochemical quantitation revealed that the treatment of keratinocytes with DHA or curcumin stimulates LCE3 protein expression, while simultaneously opposing the tumor necrosis factor-alpha (TNFalpha)-signaled phosphorylation of mitogen activated protein (MAP) kinases, p38 and Jun amino-terminal kinase (JNK), thereby overcoming inflammation biomarkers elicited by TNFalpha challenge.	Curcumin	100-108	tumor necrosis factor	Homo sapiens	383-391
29456509-7	2018	Moreover inhibition of STAT3 pathways by curcumin increased FOXA2 expression in NCI-H292 cells whereas a STAT3 activator (IL-6) significantly inhibited curcumin-induced FOXA2 expression.	Curcumin	152-160	forkhead box A2	Homo sapiens	169-174
29456509-8	2018	Also, SOCS1 and SOCS3, negative regulators of STAT3 activity, were upregulated by curcumin treatment.	Curcumin	82-90	signal transducer and activator of transcription 3	Homo sapiens	46-51
29456509-9	2018	Thus, curcumin inhibited human NCI-H292 cells growth by increasing FOXA2 expression via regulation of STAT3 signaling pathways.	Curcumin	6-14	forkhead box A2	Homo sapiens	67-72
29456509-9	2018	Thus, curcumin inhibited human NCI-H292 cells growth by increasing FOXA2 expression via regulation of STAT3 signaling pathways.	Curcumin	6-14	signal transducer and activator of transcription 3	Homo sapiens	102-107
29401702-6	2018	Finally, DHA and curcumin modulate two transcription factors relevant to psoriatic inflammation, the activator protein-1 factor Jun B and the nuclear receptor NR4A2/NURR1, that is implicated as a mediator of VDR ligand-triggered gene control.	Curcumin	17-25	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	128-133
28905939-6	2018	Curcumin administration significantly suppressed the deposition of type I and type III collagens in the heart tissues of diabetic rats, accompanied by markedly reduced TGF-beta1 production, suppressed TbetaR II levels and Smad2/3 phosphorylation, and increased Smad7 expression.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	168-177
28905939-6	2018	Curcumin administration significantly suppressed the deposition of type I and type III collagens in the heart tissues of diabetic rats, accompanied by markedly reduced TGF-beta1 production, suppressed TbetaR II levels and Smad2/3 phosphorylation, and increased Smad7 expression.	Curcumin	0-8	SMAD family member 7	Rattus norvegicus	261-266
28905939-9	2018	Application of curcumin (25 mumol/L) inhibited TGF-beta1- or HG-induced AMPK/p38 MAPK activation and suppressed collagen synthesis in the fibroblasts.	Curcumin	15-23	transforming growth factor, beta 1	Rattus norvegicus	47-56
28905939-11	2018	Our results demonstrate that curcumin suppresses diabetes-associated collagen synthesis in rat myocardium not only by inhibiting TGF-beta1 production and canonical Smad signaling but also by blocking the non-canonical AMPK/p38 MAPK pathway.	Curcumin	29-37	transforming growth factor, beta 1	Rattus norvegicus	129-138
28905939-11	2018	Our results demonstrate that curcumin suppresses diabetes-associated collagen synthesis in rat myocardium not only by inhibiting TGF-beta1 production and canonical Smad signaling but also by blocking the non-canonical AMPK/p38 MAPK pathway.	Curcumin	29-37	SMAD family member 7	Rattus norvegicus	164-168
29479379-7	2018	Conclusions: This project may provide information for the development of a translational study in humans as we noted that curcumin pretreatment in a large animal model of cardiopulmonary bypass (CPB) and extracorporeal support resulted in a decrease in TNF-alpha and ICAM-1 expression compared to control animals.	Curcumin	122-130	tumor necrosis factor	Homo sapiens	253-262
29310081-0	2018	Bovine Serum Albumin (BSA) coated iron oxide magnetic nanoparticles as biocompatible carriers for curcumin-anticancer drug.	Curcumin	98-106	albumin	Homo sapiens	7-20
29310081-1	2018	The bovine serum albumin-coated magnetic nanoparticles (F@BSA NPs) were prepared as curcumin (CUR) carriers through desolvation and chemical co-precipitation process.	Curcumin	84-92	albumin	Homo sapiens	11-24
29374713-8	2018	After exposure to curcumin, maspin-knockdown cells showed lower expression levels of pro-apoptotic proteins, Bad and Bax, as compared with control cells.	Curcumin	18-26	BCL2 associated X, apoptosis regulator	Homo sapiens	117-120
28054501-0	2018	Modulation in the conformational and stability attributes of the Alzheimer"s disease associated amyloid-beta mutants and their favorable stabilization by curcumin: molecular dynamics simulation analysis.	Curcumin	154-162	amyloid beta precursor protein	Homo sapiens	96-108
29241692-3	2018	Andrographolide and curcumin showed a marked inhibition on morphine 3- and 6-glucuronidation with IC50 of 50&amp;87 and 96&amp;111 muM, respectively.	Curcumin	20-28	latexin	Homo sapiens	131-134
28054501-6	2018	To the best of our knowledge, this is the first report on the effect of curcumin binding on structural landscapes of the two contrasting point mutants providing an understanding of the basis of Abeta plaque formation and its prevention by curcumin.	Curcumin	72-80	amyloid beta precursor protein	Homo sapiens	194-199
28054501-6	2018	To the best of our knowledge, this is the first report on the effect of curcumin binding on structural landscapes of the two contrasting point mutants providing an understanding of the basis of Abeta plaque formation and its prevention by curcumin.	Curcumin	239-247	amyloid beta precursor protein	Homo sapiens	194-199
28902433-14	2018	Curcumin also regulated the BLM and IL-17A mediated changes in p53-PAI-1 expression.	Curcumin	0-8	tumor protein p53	Homo sapiens	63-66
29315967-6	2018	Curcumin ameliorated DXR-induced lipid peroxidation, glutathione depletion, decrease in antioxidant (superoxide dismutase, catalase, and glutathione peroxidase) enzyme activities, and cardiac toxicity markers (CK-MB, LDH, and cTn-I).	Curcumin	0-8	catalase	Rattus norvegicus	123-131
29315967-7	2018	Curcumin also attenuated activities of Caspase-3, cyclooxygenase-2, inducible nitric oxide synthase, and levels of nuclear factor kappa-B, tumor necrosis factor-alpha, and interleukin-1beta, and cardiac tissue damages that were induced by DXR.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	139-166
29315967-7	2018	Curcumin also attenuated activities of Caspase-3, cyclooxygenase-2, inducible nitric oxide synthase, and levels of nuclear factor kappa-B, tumor necrosis factor-alpha, and interleukin-1beta, and cardiac tissue damages that were induced by DXR.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	172-189
28731226-10	2018	The data of the in vitro experiments showed that curcumin converted the LC patient-isolated Tregs to Th1 cells via repressing the gene transcription of forkhead protein-3 and increasing the expression of interferon-gamma.	Curcumin	49-57	interferon gamma	Homo sapiens	204-220
28771796-2	2018	The aim of the study is to establish that buffalo granulosa cells when primed with curcumin (20 muM), release improved cellular contents through exosome that can mitigate granulosa cell dysfunction.	Curcumin	83-91	latexin	Homo sapiens	96-99
28935827-9	2018	Post hoc analysis indicated I-FABP increased more from Pre to Post (87%) and 1-Post (33%) in Placebo than in Curcumin (58 and 18%, respectively).	Curcumin	109-117	fatty acid binding protein 2	Homo sapiens	28-34
28902433-0	2018	Curcumin alleviates IL-17A-mediated p53-PAI-1 expression in bleomycin-induced alveolar basal epithelial cells.	Curcumin	0-8	tumor protein p53	Homo sapiens	36-39
28902433-15	2018	Curcumin has the ability to regulate inflammatory cytokines during BLM-induced injury and their effect on p53-PAI-1 expression.	Curcumin	0-8	tumor protein p53	Homo sapiens	106-109
29034440-9	2018	Furthermore, curcumin repressed the capacity of risperidone to induce the hepatic over expression of enzymes involved in lipid metabolism (LXRalpha, FAS, ACC1, LPL, PPARgamma, ACO, SREBP2) and decreased risperidone-induced glucose intolerance and hypertriglyceridemia.	Curcumin	13-21	nuclear receptor subfamily 1, group H, member 3	Mus musculus	139-147
29443732-0	2018	Curcumin induces apoptosis and inhibits proliferation in infantile hemangioma endothelial cells via downregulation of MCL-1 and HIF-1alpha.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-138
29443732-5	2018	We also observed that treatment with curcumin induced apoptosis in HemECs, as evidenced by positively Annexin-V-FITC staining, caspase-3 activation, and cleavage of poly(adenosine diphosphate-ribose) polymerase (PARP) in the treated cells.	Curcumin	37-45	caspase 3	Homo sapiens	127-136
29443732-5	2018	We also observed that treatment with curcumin induced apoptosis in HemECs, as evidenced by positively Annexin-V-FITC staining, caspase-3 activation, and cleavage of poly(adenosine diphosphate-ribose) polymerase (PARP) in the treated cells.	Curcumin	37-45	poly(ADP-ribose) polymerase 1	Homo sapiens	165-210
29443732-5	2018	We also observed that treatment with curcumin induced apoptosis in HemECs, as evidenced by positively Annexin-V-FITC staining, caspase-3 activation, and cleavage of poly(adenosine diphosphate-ribose) polymerase (PARP) in the treated cells.	Curcumin	37-45	poly(ADP-ribose) polymerase 1	Homo sapiens	212-216
29443732-6	2018	Moreover, we showed that curcumin suppressed the expression of antiapoptotic protein myeloid cell leukemia-1 (MCL-1), hypoxia-inducible factor 1alpha (HIF-1alpha), and vascular endothelial growth factor (VEGF).Altogether, our study suggests that the effectiveness of curcumin in IHs may be associated with its potent antiproliferative and apoptotic activities in HemECs.	Curcumin	25-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	118-149
29443732-6	2018	Moreover, we showed that curcumin suppressed the expression of antiapoptotic protein myeloid cell leukemia-1 (MCL-1), hypoxia-inducible factor 1alpha (HIF-1alpha), and vascular endothelial growth factor (VEGF).Altogether, our study suggests that the effectiveness of curcumin in IHs may be associated with its potent antiproliferative and apoptotic activities in HemECs.	Curcumin	25-33	hypoxia inducible factor 1 subunit alpha	Homo sapiens	151-161
29443732-6	2018	Moreover, we showed that curcumin suppressed the expression of antiapoptotic protein myeloid cell leukemia-1 (MCL-1), hypoxia-inducible factor 1alpha (HIF-1alpha), and vascular endothelial growth factor (VEGF).Altogether, our study suggests that the effectiveness of curcumin in IHs may be associated with its potent antiproliferative and apoptotic activities in HemECs.	Curcumin	25-33	vascular endothelial growth factor A	Homo sapiens	168-202
29034440-10	2018	Curcumin decreased risperidone-induced increases in serum markers of hepatotoxicity (ALAT, ASAT), as well as of one major hepatic pro-inflammatory transcription factor (NFkappaB: p105 mRNA and p65 protein).	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	179-183
29297700-1	2018	We hypothesized that synergy between curcumin (CURC), trastuzumab (TZMB), and glutathione peroxidase-1 (GPX-1) accelerates breast cancer (BC) cell apoptosis which is inhibited by glial cell line-derived neurotrophic factor (GDNF).	Curcumin	37-45	glial cell derived neurotrophic factor	Homo sapiens	179-222
29443732-6	2018	Moreover, we showed that curcumin suppressed the expression of antiapoptotic protein myeloid cell leukemia-1 (MCL-1), hypoxia-inducible factor 1alpha (HIF-1alpha), and vascular endothelial growth factor (VEGF).Altogether, our study suggests that the effectiveness of curcumin in IHs may be associated with its potent antiproliferative and apoptotic activities in HemECs.	Curcumin	25-33	vascular endothelial growth factor A	Homo sapiens	204-208
29297700-1	2018	We hypothesized that synergy between curcumin (CURC), trastuzumab (TZMB), and glutathione peroxidase-1 (GPX-1) accelerates breast cancer (BC) cell apoptosis which is inhibited by glial cell line-derived neurotrophic factor (GDNF).	Curcumin	37-45	glial cell derived neurotrophic factor	Homo sapiens	224-228
28880787-12	2018	STAT3 inhibition with micellar curcumin also suppressed postablation stimulation of distant tumor growth, proliferation, and microvascular density (P &lt; .01).	Curcumin	31-39	signal transducer and activator of transcription 3	Mus musculus	0-5
29168312-0	2018	Curcumin mediated down-regulation of alphaV beta3 integrin and up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) in Erlotinib resistant SW480 colon cancer cells.	Curcumin	0-8	pyruvate dehydrogenase kinase 4	Homo sapiens	80-111
29168312-0	2018	Curcumin mediated down-regulation of alphaV beta3 integrin and up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) in Erlotinib resistant SW480 colon cancer cells.	Curcumin	0-8	pyruvate dehydrogenase kinase 4	Homo sapiens	113-117
29168312-2	2018	To shed light on the erlotinib-resistant pathway, this study investigated the effect of combination therapy using curcumin- and erlotinib-loaded nanoparticles on the expression of alphav beta3 integrin and pyruvate dehydrogenase kinase 4 (PDK4) in an erlotinib-resistant SW480 colon cancer cell line.	Curcumin	114-122	pyruvate dehydrogenase kinase 4	Homo sapiens	206-237
29331788-0	2018	Curcumin inhibits cardiac hypertrophy and improves cardiovascular function via enhanced Na+/Ca2+ exchanger expression after transverse abdominal aortic constriction in rats.	Curcumin	0-8	solute carrier family 8 member A1	Rattus norvegicus	88-106
29331788-1	2018	BACKGROUND: This study tested the hypothesis that inhibition of cardiac hypertrophy and preservation of cardiac/endothelial function by the natural yellow pigment curcumin are associated with upregulated expression of Na+/Ca2+ exchanger (NCX) after transverse aortic constriction (TAC).	Curcumin	163-171	solute carrier family 8 member A1	Rattus norvegicus	218-236
29331788-1	2018	BACKGROUND: This study tested the hypothesis that inhibition of cardiac hypertrophy and preservation of cardiac/endothelial function by the natural yellow pigment curcumin are associated with upregulated expression of Na+/Ca2+ exchanger (NCX) after transverse aortic constriction (TAC).	Curcumin	163-171	solute carrier family 8 member A1	Rattus norvegicus	238-241
29331788-7	2018	Along with these modifications, the expression and localization of NCX and eNOS in the myocardium and vascular endothelium were significantly upregulated by curcumin.	Curcumin	157-165	solute carrier family 8 member A1	Rattus norvegicus	67-70
29331788-8	2018	The protective effect of curcumin on endothelium-dependent relaxation was partly blocked by pretreatment with the NCX inhibitor, KB-R7943.	Curcumin	25-33	solute carrier family 8 member A1	Rattus norvegicus	114-117
29331788-9	2018	CONCLUSIONS: These results demonstrate that inhibition of cardiac hypertrophy, improvement of cardiac systolic/diastolic function and preservation of vascular endothelium by curcumin might be associated with upregulated NCX expression level in response to increased afterload.	Curcumin	174-182	solute carrier family 8 member A1	Rattus norvegicus	220-223
29351226-0	2018	Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Modulation of the Nrf2/HO-1 and TGF-beta1/Smad3 Pathway.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	101-105
29484272-14	2018	Moreover, curcumin treatment improved cell viability, reduced cell apoptosis, increased Bcl-2 protein levels while decreased Bax and caspase-3 expressions in mouse N2a cells after OGD/R injury.	Curcumin	10-18	B cell leukemia/lymphoma 2	Mus musculus	88-93
29351226-6	2018	Furthermore, curcumin pre-treatment significantly down-regulated the expression of TGF-beta1 and Smad3 mRNAs (both p &lt; 0.01), and up-regulated the expression of nuclear-factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both p &lt; 0.01) in the liver.	Curcumin	13-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	164-207
29351226-6	2018	Furthermore, curcumin pre-treatment significantly down-regulated the expression of TGF-beta1 and Smad3 mRNAs (both p &lt; 0.01), and up-regulated the expression of nuclear-factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both p &lt; 0.01) in the liver.	Curcumin	13-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	209-213
29422835-11	2017	The nanoparticle-encapsulated curcumin decreased up-regulated IL-1beta and Cx43 expression and reduced levels of phosphorylated-Akt (p-Akt) in the DRG of rats with DM.	Curcumin	30-38	interleukin 1 beta	Rattus norvegicus	62-70
29422835-11	2017	The nanoparticle-encapsulated curcumin decreased up-regulated IL-1beta and Cx43 expression and reduced levels of phosphorylated-Akt (p-Akt) in the DRG of rats with DM.	Curcumin	30-38	gap junction protein, alpha 1	Rattus norvegicus	75-79
29422835-11	2017	The nanoparticle-encapsulated curcumin decreased up-regulated IL-1beta and Cx43 expression and reduced levels of phosphorylated-Akt (p-Akt) in the DRG of rats with DM.	Curcumin	30-38	AKT serine/threonine kinase 1	Rattus norvegicus	128-131
29422835-11	2017	The nanoparticle-encapsulated curcumin decreased up-regulated IL-1beta and Cx43 expression and reduced levels of phosphorylated-Akt (p-Akt) in the DRG of rats with DM.	Curcumin	30-38	AKT serine/threonine kinase 1	Rattus norvegicus	135-138
29351226-6	2018	Furthermore, curcumin pre-treatment significantly down-regulated the expression of TGF-beta1 and Smad3 mRNAs (both p &lt; 0.01), and up-regulated the expression of nuclear-factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both p &lt; 0.01) in the liver.	Curcumin	13-21	heme oxygenase 1	Mus musculus	219-223
29351226-7	2018	Inhibition of HO-1 attenuated the protective effect of curcumin on CCl4-induced acute liver injury.	Curcumin	55-63	heme oxygenase 1	Mus musculus	14-18
29351226-8	2018	Given these outcomes, curcumin could protect against CCl4-induced acute liver injury by inhibiting oxidative stress and inflammation, which may partly involve the activation of Nrf2/HO-1 and inhibition of TGF-beta1/Smad3 pathways.	Curcumin	22-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	177-181
29351226-8	2018	Given these outcomes, curcumin could protect against CCl4-induced acute liver injury by inhibiting oxidative stress and inflammation, which may partly involve the activation of Nrf2/HO-1 and inhibition of TGF-beta1/Smad3 pathways.	Curcumin	22-30	heme oxygenase 1	Mus musculus	182-186
29351226-0	2018	Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Modulation of the Nrf2/HO-1 and TGF-beta1/Smad3 Pathway.	Curcumin	0-8	heme oxygenase 1	Mus musculus	106-110
29351226-4	2018	Curcumin pre-treatment at 50, 100 and 200 mg/kg significantly ameliorated CCl4-induced oxidative stress, characterized by decreased malondialdehyde (MDA) formations, and increased superoxide dismutase (SOD), catalase (CAT) activities and glutathione (GSH) content, followed by a decrease in caspase-9 and -3 activities.	Curcumin	0-8	catalase	Mus musculus	208-216
29351226-4	2018	Curcumin pre-treatment at 50, 100 and 200 mg/kg significantly ameliorated CCl4-induced oxidative stress, characterized by decreased malondialdehyde (MDA) formations, and increased superoxide dismutase (SOD), catalase (CAT) activities and glutathione (GSH) content, followed by a decrease in caspase-9 and -3 activities.	Curcumin	0-8	catalase	Mus musculus	218-221
29224353-0	2018	Curcumin Protects against Atherosclerosis in Apolipoprotein E-Knockout Mice by Inhibiting Toll-like Receptor 4 Expression.	Curcumin	0-8	apolipoprotein E	Mus musculus	45-61
29224353-1	2018	Toll-like receptor 4 (TLR4) has been reported to play a critical role in the pathogenesis of atherosclerosis, the current study aimed to investigate whether curcumin suppresses atherosclerosis development in ApoE-knockout (ApoE-/-) mice by inhibiting TLR4 expression.	Curcumin	157-165	toll-like receptor 4	Mus musculus	22-26
29224353-0	2018	Curcumin Protects against Atherosclerosis in Apolipoprotein E-Knockout Mice by Inhibiting Toll-like Receptor 4 Expression.	Curcumin	0-8	toll-like receptor 4	Mus musculus	90-110
29224353-1	2018	Toll-like receptor 4 (TLR4) has been reported to play a critical role in the pathogenesis of atherosclerosis, the current study aimed to investigate whether curcumin suppresses atherosclerosis development in ApoE-knockout (ApoE-/-) mice by inhibiting TLR4 expression.	Curcumin	157-165	apolipoprotein E	Mus musculus	208-212
29221948-3	2018	In primary cultured rat microglia, CNB-001 (1-10microM) suppressed the lipopolysaccharide (LPS)-induced nitric oxide (NO) production and expression of inducible NO synthase (iNOS), and the potency of CNB-001 was stronger than curcumin.	Curcumin	226-234	nitric oxide synthase 2	Rattus norvegicus	174-178
29224353-3	2018	Curcumin supplementation significantly reduced TLR4 expression and macrophage infiltration in atherosclerotic plaques.	Curcumin	0-8	toll-like receptor 4	Mus musculus	47-51
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	interleukin 1 beta	Mus musculus	29-46
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	interleukin 1 beta	Mus musculus	48-56
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	tumor necrosis factor	Mus musculus	59-86
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	tumor necrosis factor	Mus musculus	88-97
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	202-223
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	225-234
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	interleukin 1 beta	Mus musculus	257-265
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	tumor necrosis factor	Mus musculus	267-276
29224353-6	2018	In vitro, curcumin inhibited NF-kappaB activation in macrophages and reduced TLR4 expression induced by lipopolysaccharide.	Curcumin	10-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	29-38
29224353-6	2018	In vitro, curcumin inhibited NF-kappaB activation in macrophages and reduced TLR4 expression induced by lipopolysaccharide.	Curcumin	10-18	toll-like receptor 4	Mus musculus	77-81
29224353-7	2018	Our results indicate that curcumin protects against atherosclerosis at least partially by inhibiting TLR4 expression and its related inflammatory reaction.	Curcumin	26-34	toll-like receptor 4	Mus musculus	101-105
29581972-9	2018	This was accompanied by an increase in caspase-3/caspase-7 activities after cell treatment with curcumin-nanoemulsion and Photodynamic Therapy, suggesting cell death by apoptosis.	Curcumin	96-104	caspase 3	Homo sapiens	39-48
29435420-3	2018	Following incubation with curcumin, intrinsic tryptophan fluorescence emission of apolipoprotein (apo) A-I was strongly quenched.	Curcumin	26-34	apolipoprotein A1	Homo sapiens	82-106
29223538-0	2018	Curcumin induces osteoblast differentiation through mild-endoplasmic reticulum stress-mediated such as BMP2 on osteoblast cells.	Curcumin	0-8	bone morphogenetic protein 2	Mus musculus	103-107
29541412-7	2018	Inhibiting ERK phosphorylation stimulated the chemosensitizing effect of curcumin to cisplatin by targeting FEN1.	Curcumin	73-81	mitogen-activated protein kinase 1	Homo sapiens	11-14
29316620-6	2018	Other phytochemicals such as curcumin, resveratrol, and anthocyanins also inhibit COX2.	Curcumin	29-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-86
29435420-5	2018	The fluorescence emission spectra of curcumin in the presence of amyloid-like aggregates formed by methionine-oxidized (ox) apoA-I varied, depending on whether curcumin was added before, or after, aggregate formation.	Curcumin	37-45	apolipoprotein A1	Homo sapiens	124-130
29435420-6	2018	The impact of curcumin on the structure of the aggregating material was revealed by the lower amount of beta-structure in ox-apoA-I amyloid-like aggregates formed in the presence of curcumin, compared to aggregates formed without curcumin.	Curcumin	14-22	apolipoprotein A1	Homo sapiens	125-131
29435420-9	2018	In conclusion, curcumin interacts with apoA-I and alters the structure of ox-apoA-I amyloid-like aggregates yet does not diminish the propensity of ox-apoA-I to form aggregates.	Curcumin	15-23	apolipoprotein A1	Homo sapiens	39-45
29435420-9	2018	In conclusion, curcumin interacts with apoA-I and alters the structure of ox-apoA-I amyloid-like aggregates yet does not diminish the propensity of ox-apoA-I to form aggregates.	Curcumin	15-23	apolipoprotein A1	Homo sapiens	77-83
29435420-9	2018	In conclusion, curcumin interacts with apoA-I and alters the structure of ox-apoA-I amyloid-like aggregates yet does not diminish the propensity of ox-apoA-I to form aggregates.	Curcumin	15-23	apolipoprotein A1	Homo sapiens	77-83
30149755-0	2018	Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder Cancer.	Curcumin	0-8	cyclin dependent kinase inhibitor 2A	Homo sapiens	57-60
29614882-3	2018	Our previous study showed that Curcumin activates lysosome and induce autophagy through inhibition of AKT (protein kinase K, PKB)-mammalian target of rapamycin (mTOR) pathway.	Curcumin	31-39	AKT serine/threonine kinase 1	Homo sapiens	102-105
29614882-3	2018	Our previous study showed that Curcumin activates lysosome and induce autophagy through inhibition of AKT (protein kinase K, PKB)-mammalian target of rapamycin (mTOR) pathway.	Curcumin	31-39	AKT serine/threonine kinase 1	Homo sapiens	125-128
29614882-3	2018	Our previous study showed that Curcumin activates lysosome and induce autophagy through inhibition of AKT (protein kinase K, PKB)-mammalian target of rapamycin (mTOR) pathway.	Curcumin	31-39	mechanistic target of rapamycin kinase	Homo sapiens	130-159
28639178-2	2018	Curcumin was encapsulated in DOTAP-based cationic liposomes and then complexed with STAT3 siRNA.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	84-89
28639178-4	2018	The cell viability studies in B16F10 mouse melanoma cells have shown that the co-delivery of curcumin and STAT3 siRNA significantly (p &lt; 0.05) inhibited the cancer cell growth compared with either liposomal curcumin or STAT3 siRNA alone.	Curcumin	93-101	signal transducer and activator of transcription 3	Mus musculus	222-227
28639178-7	2018	Co-administration of the curcumin and STAT3 siRNA using liposomes significantly (p &lt; 0.05) inhibited the tumor progression as measured by tumor volume and tumor weight compared with either liposomal curcumin or STAT3 siRNA alone.	Curcumin	25-33	signal transducer and activator of transcription 3	Mus musculus	214-219
28639178-7	2018	Co-administration of the curcumin and STAT3 siRNA using liposomes significantly (p &lt; 0.05) inhibited the tumor progression as measured by tumor volume and tumor weight compared with either liposomal curcumin or STAT3 siRNA alone.	Curcumin	202-210	signal transducer and activator of transcription 3	Mus musculus	38-43
28639178-8	2018	Furthermore, the iontophoretic administration of curcumin-loaded liposome-siRNA complex showed similar effectiveness in inhibiting tumor progression and STAT3 protein suppression compared with intratumoral administration.	Curcumin	49-57	signal transducer and activator of transcription 3	Mus musculus	153-158
29614882-3	2018	Our previous study showed that Curcumin activates lysosome and induce autophagy through inhibition of AKT (protein kinase K, PKB)-mammalian target of rapamycin (mTOR) pathway.	Curcumin	31-39	mechanistic target of rapamycin kinase	Homo sapiens	161-165
30149755-9	2018	Curcumin induces the downregulation of miR-7641 and subsequent upregulation of p16 which is a target of miR-7641 at the post-transcriptional level, which leads to the decreased invasion and increased apoptosis of bladder cancer cells.	Curcumin	0-8	cyclin dependent kinase inhibitor 2A	Homo sapiens	79-82
30580635-0	2018	Anti-tumour effects of TRAIL-expressing human placental derived mesenchymal stem cells with curcumin-loaded chitosan nanoparticles in a mice model of triple negative breast cancer.	Curcumin	92-100	TNF superfamily member 10	Homo sapiens	23-28
29866021-0	2018	Curcumin Modulates Glycolytic Metabolism and Inflammatory Cytokines via Nrf 2 in Dalton"s Lymphoma Ascites Cells In Vivo.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	72-77
29866021-4	2018	OBJECTIVE: In continuation with our previous studies illustrating the long-term effect of curcumin using a liver tissue, present study was aimed to elucidate the anti-cancer effect of curcumin due to its long-term effect in the regulation of glycolytic metabolism, NF-kappaB activation, expression of proinflammatory cytokines in Dalton"s lymphoma ascites cells in vivo.	Curcumin	184-192	nuclear factor kappa B subunit 1	Homo sapiens	265-274
29866021-6	2018	RESULTS: Results revealed that curcumin-induced activation of antioxidant enzymes, Nrf2 and downstream signaling gene NQO1.	Curcumin	31-39	NFE2 like bZIP transcription factor 2	Homo sapiens	83-87
29866021-6	2018	RESULTS: Results revealed that curcumin-induced activation of antioxidant enzymes, Nrf2 and downstream signaling gene NQO1.	Curcumin	31-39	NAD(P)H quinone dehydrogenase 1	Homo sapiens	118-122
29866021-8	2018	Activation of NF-kappaB, expression of COX2, HIF-1alpha and cMyc, as well as expression and activity of LDH-A were significantly reduced by curcumin.	Curcumin	140-148	nuclear factor kappa B subunit 1	Homo sapiens	14-23
29866021-8	2018	Activation of NF-kappaB, expression of COX2, HIF-1alpha and cMyc, as well as expression and activity of LDH-A were significantly reduced by curcumin.	Curcumin	140-148	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-43
29866021-8	2018	Activation of NF-kappaB, expression of COX2, HIF-1alpha and cMyc, as well as expression and activity of LDH-A were significantly reduced by curcumin.	Curcumin	140-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-55
29866021-8	2018	Activation of NF-kappaB, expression of COX2, HIF-1alpha and cMyc, as well as expression and activity of LDH-A were significantly reduced by curcumin.	Curcumin	140-148	lactate dehydrogenase A	Homo sapiens	104-109
29866021-10	2018	CONCLUSION: Curcumin downregulates glycolytic metabolism via modulation of stress-activated genes and reduces oxidative stress by enhancing antioxidant defence system, which inhibits activation of NF-kappaB signaling and expression of proinflammatory cytokines in Dalton"s lymphoma ascites cells in vivo.	Curcumin	12-20	nuclear factor kappa B subunit 1	Homo sapiens	197-206
29127008-0	2018	Direct regulation of IL-2 by curcumin.	Curcumin	29-37	interleukin 2	Homo sapiens	21-25
28561324-7	2018	Curcumin further reduced adenine-induced hypertension, urinary albumin, the inflammatory cytokines IL-1beta, IL-6 and TNF-alpha, cystatin C and adiponectin.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	99-107
28561324-7	2018	Curcumin further reduced adenine-induced hypertension, urinary albumin, the inflammatory cytokines IL-1beta, IL-6 and TNF-alpha, cystatin C and adiponectin.	Curcumin	0-8	interleukin 6	Rattus norvegicus	109-113
28561324-7	2018	Curcumin further reduced adenine-induced hypertension, urinary albumin, the inflammatory cytokines IL-1beta, IL-6 and TNF-alpha, cystatin C and adiponectin.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	118-127
28561324-9	2018	In animals treated with the two higher curcumin concentrations, alone or in combination with adenine, an increased expression of the antioxidative transcription factor Nrf2 was found as well as up-regulation of the activity of its direct target glutathione reductase, and of an indirect target, the glutathione level.	Curcumin	39-47	NFE2 like bZIP transcription factor 2	Rattus norvegicus	168-172
28561324-10	2018	In conclusion, curcumin exhibits salutary effects against adenine-induced CKD in rats by reducing inflammation and oxidative stress via up-regulation of the transcription factor Nrf2.	Curcumin	15-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	178-182
29127008-4	2018	In this study, we screened an herbal library to identify a compound that regulates IL-2, which resulted in the identification of curcumin as a direct binder and inhibitor of IL-2.	Curcumin	129-137	interleukin 2	Homo sapiens	83-87
29127008-4	2018	In this study, we screened an herbal library to identify a compound that regulates IL-2, which resulted in the identification of curcumin as a direct binder and inhibitor of IL-2.	Curcumin	129-137	interleukin 2	Homo sapiens	174-178
29127008-6	2018	In this study, curcumin mimicked or altered the binding pattern of anti-IL-2 Abs against IL-2 and remarkably inhibited the interaction of recombinant IL-2 with the IL-2 receptor alpha, CD25.	Curcumin	15-23	interleukin 2	Homo sapiens	72-76
29127008-6	2018	In this study, curcumin mimicked or altered the binding pattern of anti-IL-2 Abs against IL-2 and remarkably inhibited the interaction of recombinant IL-2 with the IL-2 receptor alpha, CD25.	Curcumin	15-23	interleukin 2	Homo sapiens	89-93
29127008-6	2018	In this study, curcumin mimicked or altered the binding pattern of anti-IL-2 Abs against IL-2 and remarkably inhibited the interaction of recombinant IL-2 with the IL-2 receptor alpha, CD25.	Curcumin	15-23	interleukin 2	Homo sapiens	89-93
29127008-7	2018	Interestingly, curcumin neutralized the biological activities of IL-2 both in vitro and in vivo.	Curcumin	15-23	interleukin 2	Homo sapiens	65-69
29127008-8	2018	In this report, we elucidated the unsolved mechanism of the anti-cancer effect of curcumin by identifying IL-2 as a direct molecular target.	Curcumin	82-90	interleukin 2	Homo sapiens	106-110
29127008-9	2018	Curcumin, as a small molecule IL-2 modulator, has the potential to be used to treat IL-2 related pathologic conditions.	Curcumin	0-8	interleukin 2	Homo sapiens	30-34
29127008-9	2018	Curcumin, as a small molecule IL-2 modulator, has the potential to be used to treat IL-2 related pathologic conditions.	Curcumin	0-8	interleukin 2	Homo sapiens	84-88
28914666-5	2018	The pleiotropic nonselective MCP-1/CCR2 inhibition by current pharmacological agents is thought to contribute to their anti-inflammatory and antiatherosclerotic effects that is also seen for nutraceutical compounds such as curcumin.	Curcumin	223-231	C-C motif chemokine receptor 2	Homo sapiens	35-39
29793316-0	2018	Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	20-23
29793316-0	2018	Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells.	Curcumin	0-8	insulin	Homo sapiens	57-64
29793316-1	2018	OBJECTIVE: To examine whether curcumin has protective effect on insulin resistance induced by bisphenol A (BPA) in LO2 cells and whether this effect was mediated by inhibiting the inflammatory mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-kappaB) pathways.	Curcumin	30-38	insulin	Homo sapiens	64-71
29793316-4	2018	RESULTS: Curcumin prevented BPA-induced reduction of glucose consumption and suppression of insulin signaling pathway, indicating curcumin alleviated BPA-triggered insulin resistance in LO2 cells.	Curcumin	9-17	insulin	Homo sapiens	92-99
29793316-4	2018	RESULTS: Curcumin prevented BPA-induced reduction of glucose consumption and suppression of insulin signaling pathway, indicating curcumin alleviated BPA-triggered insulin resistance in LO2 cells.	Curcumin	130-138	insulin	Homo sapiens	92-99
29793316-4	2018	RESULTS: Curcumin prevented BPA-induced reduction of glucose consumption and suppression of insulin signaling pathway, indicating curcumin alleviated BPA-triggered insulin resistance in LO2 cells.	Curcumin	130-138	insulin	Homo sapiens	164-171
29793316-5	2018	mRNA and proteins levels of TNF-alpha and IL-6, as well as MDA level in LO2 cells treated with BPA were decreased by curcumin.	Curcumin	117-125	tumor necrosis factor	Homo sapiens	28-37
29793316-5	2018	mRNA and proteins levels of TNF-alpha and IL-6, as well as MDA level in LO2 cells treated with BPA were decreased by curcumin.	Curcumin	117-125	interleukin 6	Homo sapiens	42-46
29793316-6	2018	Furthermore, curcumin downregulated the activation of p38, JNK, and NF-kappaB pathways upon stimulation with BPA.	Curcumin	13-21	mitogen-activated protein kinase 14	Homo sapiens	54-57
29793316-6	2018	Furthermore, curcumin downregulated the activation of p38, JNK, and NF-kappaB pathways upon stimulation with BPA.	Curcumin	13-21	mitogen-activated protein kinase 8	Homo sapiens	59-62
29793316-8	2018	CONCLUSION: Curcumin inhibits BPA-induced insulin resistance by suppressing JNK pathway.	Curcumin	12-20	insulin	Homo sapiens	42-49
29793316-8	2018	CONCLUSION: Curcumin inhibits BPA-induced insulin resistance by suppressing JNK pathway.	Curcumin	12-20	mitogen-activated protein kinase 8	Homo sapiens	76-79
29089332-6	2018	Evaluation of the molecular mechanisms underlying the chemopreventive and antitumor effects of curcumin revealed that NF-kappaB and STAT3 signaling pathways were significantly inhibited but that the nuclear factor erythroid 2/heme oxygenase 1 antioxidant pathway was induced by curcumin intake in a dose-dependent manner in ovarian tissues (P &lt; 0.05).	Curcumin	95-103	signal transducer and activator of transcription 3	Gallus gallus	132-137
29089332-7	2018	Sequencing of the Ras family genes (KRAS, NRAS, and HRAS) revealed less frequent KRAS and HRAS mutations in ovarian tumors in the curcumin-fed animals.	Curcumin	130-138	KRAS proto-oncogene, GTPase	Gallus gallus	36-40
29089332-7	2018	Sequencing of the Ras family genes (KRAS, NRAS, and HRAS) revealed less frequent KRAS and HRAS mutations in ovarian tumors in the curcumin-fed animals.	Curcumin	130-138	KRAS proto-oncogene, GTPase	Gallus gallus	81-85
29938621-2	2018	Curcumin and omega-3 fatty acids can exert neuroprotective effects through modulation of IL-6 gene expression and CRP levels.	Curcumin	0-8	interleukin 6	Homo sapiens	89-93
29938621-2	2018	Curcumin and omega-3 fatty acids can exert neuroprotective effects through modulation of IL-6 gene expression and CRP levels.	Curcumin	0-8	C-reactive protein	Homo sapiens	114-117
29938621-3	2018	The aim of present study is the evaluation of combined effects of omega-3 fatty acids and nano-curcumin supplementation on IL-6 gene expression and serum level and hs-CRP levels in migraine patients.	Curcumin	95-103	interleukin 6	Homo sapiens	123-127
29938621-7	2018	hs-CRP serum levels significantly decrease in combination and nano-curcumin within groups (P&lt;0.05).	Curcumin	67-75	C-reactive protein	Homo sapiens	3-6
29080451-5	2018	Western blot showed curcumin induced gamma-H2AX foci in CH12F3 lymphoma cells, which suggests curcumin induces DNA breaks.	Curcumin	20-28	H2A.X variant histone	Mus musculus	37-47
29080451-5	2018	Western blot showed curcumin induced gamma-H2AX foci in CH12F3 lymphoma cells, which suggests curcumin induces DNA breaks.	Curcumin	94-102	H2A.X variant histone	Mus musculus	37-47
30355954-9	2018	RESULTS: Curcumin had a promising inhibitory effect on osteolysis induced by wear debris and suppressed the RANK/c-Fos/NFATc1 signaling pathway.	Curcumin	9-17	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	119-125
30355954-11	2018	An inhibitory effect on the RANK/c-Fos/NFATc1 signaling pathway may explain the anti-osteolysis activity of curcumin.	Curcumin	108-116	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	39-45
28618991-11	2018	In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1).	Curcumin	40-48	NFE2 like bZIP transcription factor 2	Homo sapiens	135-178
28618991-11	2018	In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1).	Curcumin	40-48	NFE2 like bZIP transcription factor 2	Homo sapiens	180-184
30156145-6	2018	The findings demonstrated the significant association between curcumin intake and reduced fasting glucose levels (SMD -0.78; 95% CI, -1.20, -0.37; P&lt;0.001), homeostasis model of assessment-estimated insulin resistance (SMD -0.91; 95% CI, -1.52, -0.31; P=0.003) and HbA1c (SMD -0.92; 95% CI, -1.37, -0.47; P&lt;0.001).	Curcumin	62-70	insulin	Homo sapiens	202-209
30156145-8	2018	However, curcumin intake significantly increased insulin levels (SMD 0.92; 95% CI, 0.06, 1.78; P=0.036).	Curcumin	9-17	insulin	Homo sapiens	49-56
28322158-0	2018	Effect and Mechanism of Curcumin on EZH2 - miR-101 Regulatory Feedback Loop in Multiple Myeloma.	Curcumin	24-32	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	36-40
30062967-0	2018	Curcumin Reduces Neuronal Loss and Inhibits the NLRP3 Inflammasome Activation in an Epileptic Rat Model.	Curcumin	0-8	NLR family, pyrin domain containing 3	Rattus norvegicus	48-53
30062967-11	2018	Western blot showed that KA stimulation increased the expression of IL-1beta and NLRP3, which were reduced by curcumin treatment.	Curcumin	110-118	interleukin 1 beta	Rattus norvegicus	68-76
30062967-11	2018	Western blot showed that KA stimulation increased the expression of IL-1beta and NLRP3, which were reduced by curcumin treatment.	Curcumin	110-118	NLR family, pyrin domain containing 3	Rattus norvegicus	81-86
30062967-13	2018	CONCLUSION: Curcumin inhibits KA-induced epileptic syndromes via suppression of NLRP3 inflammasome activation; therefore, offers a potential therapy for epilepsy.	Curcumin	12-20	NLR family, pyrin domain containing 3	Rattus norvegicus	80-85
28322158-11	2018	Curcumin induced apoptosis by inhibiting the expression of EZH2, and the apoptosis rates were 16.42% and 25.62% when the RPMI8226 cells incubated with 5 and 10 micromol/L of curcumin.	Curcumin	0-8	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	59-63
28322158-11	2018	Curcumin induced apoptosis by inhibiting the expression of EZH2, and the apoptosis rates were 16.42% and 25.62% when the RPMI8226 cells incubated with 5 and 10 micromol/L of curcumin.	Curcumin	174-182	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	59-63
28322158-16	2018	CONCLUSION: Our experiments verified that the effect and mechanism of curcumin on multiple myeloma is via EZH2 - miR-101 regulatory feedback loop, which would lead us to a new way of investigating multiple myeloma and come up with new therapies in treating the disease.	Curcumin	70-78	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	106-110
29141538-7	2018	Curcumin inhibits HDAC activity, and down-regulates the expression of HDAC types 1, 2, 3, 4, 5, 6, 8 and 11 in different cancer cell lines and mice, while the activity and expression of HDAC2 have been reported to be up-regulated by curcumin in COPD and heart failure models.	Curcumin	0-8	histone deacetylase 2	Mus musculus	186-191
29141538-7	2018	Curcumin inhibits HDAC activity, and down-regulates the expression of HDAC types 1, 2, 3, 4, 5, 6, 8 and 11 in different cancer cell lines and mice, while the activity and expression of HDAC2 have been reported to be up-regulated by curcumin in COPD and heart failure models.	Curcumin	233-241	histone deacetylase 2	Mus musculus	186-191
29424917-17	2018	Meanwhile, the downregulating of p-JAK, p-SATA3 and total STAT3 were caused by curcumin but NAC had no such influence.	Curcumin	79-87	signal transducer and activator of transcription 3	Homo sapiens	58-63
29223100-0	2018	Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin.	Curcumin	64-72	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
29223100-5	2018	The natural product curcumin exhibits numerous biological activities including ability to induce the expression of Nrf2-dependent phase II and anti-oxidant enzymes.	Curcumin	20-28	NFE2 like bZIP transcription factor 2	Homo sapiens	115-119
29223100-9	2018	Activators of Nrf2 were found in all three groups, many of which were more active than curcumin.	Curcumin	87-95	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
29424917-19	2018	CONCLUSIONS: Curcumin could increase cell adhesion through inhibiting JAK/STAT3 mediated by ER in Eca-109.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	74-79
29172709-0	2018	Curcumin Suppresses In Vitro Proliferation and Invasion of Human Prostate Cancer Stem Cells by Modulating DLK1-DIO3 Imprinted Gene Cluster MicroRNAs.	Curcumin	0-8	delta like non-canonical Notch ligand 1	Homo sapiens	106-110
29172709-0	2018	Curcumin Suppresses In Vitro Proliferation and Invasion of Human Prostate Cancer Stem Cells by Modulating DLK1-DIO3 Imprinted Gene Cluster MicroRNAs.	Curcumin	0-8	iodothyronine deiodinase 3	Homo sapiens	111-115
29172709-6	2018	The miR-770-5p and miR-1247 expression levels in the DLK1-DIO3 imprinted gene cluster were significantly different between the curcumin-treated and control HuPCaSCs.	Curcumin	127-135	delta like non-canonical Notch ligand 1	Homo sapiens	53-57
29172709-6	2018	The miR-770-5p and miR-1247 expression levels in the DLK1-DIO3 imprinted gene cluster were significantly different between the curcumin-treated and control HuPCaSCs.	Curcumin	127-135	iodothyronine deiodinase 3	Homo sapiens	58-62
29172709-9	2018	CONCLUSIONS: Curcumin can suppress HuPCaSC proliferation and invasion in vitro by modulating specific miRNAs in the DLK1-DIO3 imprinted gene cluster.	Curcumin	13-21	delta like non-canonical Notch ligand 1	Homo sapiens	116-120
29172709-9	2018	CONCLUSIONS: Curcumin can suppress HuPCaSC proliferation and invasion in vitro by modulating specific miRNAs in the DLK1-DIO3 imprinted gene cluster.	Curcumin	13-21	iodothyronine deiodinase 3	Homo sapiens	121-125
29332042-0	2018	Protective Effects of Indian Spice Curcumin Against Amyloid-beta in Alzheimer"s Disease.	Curcumin	35-43	amyloid beta precursor protein	Homo sapiens	52-64
29115589-6	2018	The results revealed that curcumin dose-dependently inhibited Pam3CSK4-induced nitric oxide, PGE2, and TNF-alpha secretion.	Curcumin	26-34	tumor necrosis factor	Mus musculus	103-112
29115589-7	2018	Curcumin suppressed the secretion of inflammatory mediators through an increase in the expression of HO-1.	Curcumin	0-8	heme oxygenase 1	Mus musculus	101-105
29115589-8	2018	Curcumin induced HO-1 transcription and translation through the Nrf2/antioxidant response element signaling pathway.	Curcumin	0-8	heme oxygenase 1	Mus musculus	17-21
29115589-8	2018	Curcumin induced HO-1 transcription and translation through the Nrf2/antioxidant response element signaling pathway.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	64-68
29115589-9	2018	Inhibitory experiments revealed that HO-1 was required for the anti-inflammatory effects of curcumin.	Curcumin	92-100	heme oxygenase 1	Mus musculus	37-41
29115589-10	2018	Further mechanistic studies demonstrated that curcumin inhibited neuroinflammation by suppressing NF-kappaB and MAPK signaling pathways in Pam3CSK4-activated microglial cells.	Curcumin	46-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	98-107
29332042-1	2018	The purpose of our article is to assess the current understanding of Indian spice, curcumin, against amyloid-beta (Abeta)-induced toxicity in Alzheimer"s disease (AD) pathogenesis.	Curcumin	83-91	amyloid beta precursor protein	Homo sapiens	101-113
29332042-1	2018	The purpose of our article is to assess the current understanding of Indian spice, curcumin, against amyloid-beta (Abeta)-induced toxicity in Alzheimer"s disease (AD) pathogenesis.	Curcumin	83-91	amyloid beta precursor protein	Homo sapiens	115-120
29332042-5	2018	Recent research on Abeta and curcumin has revealed that curcumin prevents Abeta aggregation and crosses the blood-brain barrier, reach brain cells, and protect neurons from various toxic insults of aging and Abeta in humans.	Curcumin	29-37	amyloid beta precursor protein	Homo sapiens	74-79
29332042-5	2018	Recent research on Abeta and curcumin has revealed that curcumin prevents Abeta aggregation and crosses the blood-brain barrier, reach brain cells, and protect neurons from various toxic insults of aging and Abeta in humans.	Curcumin	56-64	amyloid beta precursor protein	Homo sapiens	19-24
29332042-5	2018	Recent research on Abeta and curcumin has revealed that curcumin prevents Abeta aggregation and crosses the blood-brain barrier, reach brain cells, and protect neurons from various toxic insults of aging and Abeta in humans.	Curcumin	56-64	amyloid beta precursor protein	Homo sapiens	74-79
28780751-0	2018	Role of curcumin in PLD activation by Arf6-cytohesin1 signaling axis in U46619-stimulated pulmonary artery smooth muscle cells.	Curcumin	8-16	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	20-23
29578162-0	2018	The autophagy induced by curcumin via MEK/ERK pathway plays an early anti-leukemia role in human Philadelphia chromosome-positive acute lymphoblastic leukemia SUP-B15 cells.	Curcumin	25-33	mitogen-activated protein kinase kinase 7	Homo sapiens	38-41
29578162-3	2018	We demonstrated that curcumin inhibited activation of Akt-mTOR, ABL/STAT5 pathways, inhibited cell proliferation, and induced apoptosis in Ph + ALL cells.	Curcumin	21-29	AKT serine/threonine kinase 1	Homo sapiens	54-57
29578162-3	2018	We demonstrated that curcumin inhibited activation of Akt-mTOR, ABL/STAT5 pathways, inhibited cell proliferation, and induced apoptosis in Ph + ALL cells.	Curcumin	21-29	mechanistic target of rapamycin kinase	Homo sapiens	58-62
29578162-4	2018	Experiments here, were conducted to determine whether autophagy via MEK/ERK pathway involved in anti-leukemia effect of curcumin in Ph + ALL.	Curcumin	120-128	mitogen-activated protein kinase kinase 7	Homo sapiens	68-71
29578162-9	2018	Results: Curcumin treatment up-regulated the activation of RAF/MEK/ERK at 4 h and 8 h after curcumin exposure in SUP-B15 cells, curcumin treatment induced autophagy at exactly 4 h and 8 h after curcumin exposure.	Curcumin	9-17	mitogen-activated protein kinase kinase 7	Homo sapiens	63-66
29578162-9	2018	Results: Curcumin treatment up-regulated the activation of RAF/MEK/ERK at 4 h and 8 h after curcumin exposure in SUP-B15 cells, curcumin treatment induced autophagy at exactly 4 h and 8 h after curcumin exposure.	Curcumin	92-100	mitogen-activated protein kinase kinase 7	Homo sapiens	63-66
29578162-9	2018	Results: Curcumin treatment up-regulated the activation of RAF/MEK/ERK at 4 h and 8 h after curcumin exposure in SUP-B15 cells, curcumin treatment induced autophagy at exactly 4 h and 8 h after curcumin exposure.	Curcumin	128-136	mitogen-activated protein kinase kinase 7	Homo sapiens	63-66
29578162-9	2018	Results: Curcumin treatment up-regulated the activation of RAF/MEK/ERK at 4 h and 8 h after curcumin exposure in SUP-B15 cells, curcumin treatment induced autophagy at exactly 4 h and 8 h after curcumin exposure.	Curcumin	128-136	mitogen-activated protein kinase kinase 7	Homo sapiens	63-66
29578162-11	2018	MEK specific inhibitor U0126 inhibited the occurrence of autophagy, and then blocked curcumin-induced cytotoxicity at 4 h and 8 h. Conclusions: Curcumin induce autophagic cell death in SUP-B15 cells via activating RAF/MEK/ERK pathway.	Curcumin	85-93	mitogen-activated protein kinase kinase 7	Homo sapiens	0-3
29578162-11	2018	MEK specific inhibitor U0126 inhibited the occurrence of autophagy, and then blocked curcumin-induced cytotoxicity at 4 h and 8 h. Conclusions: Curcumin induce autophagic cell death in SUP-B15 cells via activating RAF/MEK/ERK pathway.	Curcumin	85-93	mitogen-activated protein kinase kinase 7	Homo sapiens	218-221
29578162-11	2018	MEK specific inhibitor U0126 inhibited the occurrence of autophagy, and then blocked curcumin-induced cytotoxicity at 4 h and 8 h. Conclusions: Curcumin induce autophagic cell death in SUP-B15 cells via activating RAF/MEK/ERK pathway.	Curcumin	144-152	mitogen-activated protein kinase kinase 7	Homo sapiens	0-3
29578162-11	2018	MEK specific inhibitor U0126 inhibited the occurrence of autophagy, and then blocked curcumin-induced cytotoxicity at 4 h and 8 h. Conclusions: Curcumin induce autophagic cell death in SUP-B15 cells via activating RAF/MEK/ERK pathway.	Curcumin	144-152	mitogen-activated protein kinase kinase 7	Homo sapiens	218-221
29243061-9	2018	Curcumin in MCAO rats significantly improved brain damage and neurological function by upregulating p-Akt and p-mTOR and downregulating LC3-II/LC3-I, IL-1, TLR4, p-38, and p-p38.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
29243061-9	2018	Curcumin in MCAO rats significantly improved brain damage and neurological function by upregulating p-Akt and p-mTOR and downregulating LC3-II/LC3-I, IL-1, TLR4, p-38, and p-p38.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	156-160
29243061-11	2018	Curcumin exerts neuroprotective effects by attenuating autophagic activities through mediating the PI3K/Akt/mTOR pathway, while also suppressing an inflammatory reaction by regulating the TLR4/p38/MAPK pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	104-107
29243061-11	2018	Curcumin exerts neuroprotective effects by attenuating autophagic activities through mediating the PI3K/Akt/mTOR pathway, while also suppressing an inflammatory reaction by regulating the TLR4/p38/MAPK pathway.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	188-192
28780751-0	2018	Role of curcumin in PLD activation by Arf6-cytohesin1 signaling axis in U46619-stimulated pulmonary artery smooth muscle cells.	Curcumin	8-16	cytohesin 1	Homo sapiens	43-53
28780751-5	2018	Treatment of PASMCs with U46619 stimulated PLD activity in the cell membrane, which was inhibited upon pretreatment with SQ29548 (Tp receptor antagonist), FIPI (PLD inhibitor), SecinH3 (inhibitor of cytohesins), and curcumin.	Curcumin	216-224	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	43-46
27957686-3	2018	Pretreatment with curcumin at 5, 10, and 20 muM for 2 h prior to colistin (200 muM) exposure for 24 h, produced an anti-inflammatory effect by significantly down-regulating the expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2), phosphorylation of the inhibitor of nuclear factor-kappa B (NF-kappaB) (p-IkappaB)-alpha, and concomitantly NF-kappaB levels.	Curcumin	18-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	284-306
28780751-8	2018	Cytohesin-1 appeared to be necessary for in vitro binding of GTPgammaS with Arf-6; however, addition of curcumin inhibited binding of GTPgammaS with Arf-6 even in the presence of cytohesin-1.	Curcumin	104-112	cytohesin 1	Homo sapiens	179-190
27957686-3	2018	Pretreatment with curcumin at 5, 10, and 20 muM for 2 h prior to colistin (200 muM) exposure for 24 h, produced an anti-inflammatory effect by significantly down-regulating the expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2), phosphorylation of the inhibitor of nuclear factor-kappa B (NF-kappaB) (p-IkappaB)-alpha, and concomitantly NF-kappaB levels.	Curcumin	18-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	308-318
27957686-3	2018	Pretreatment with curcumin at 5, 10, and 20 muM for 2 h prior to colistin (200 muM) exposure for 24 h, produced an anti-inflammatory effect by significantly down-regulating the expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2), phosphorylation of the inhibitor of nuclear factor-kappa B (NF-kappaB) (p-IkappaB)-alpha, and concomitantly NF-kappaB levels.	Curcumin	18-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	308-317
27957686-4	2018	Moreover, curcumin significantly decreased intracellular reactive oxygen species (ROS) production and increased the activities of the anti-ROS enzymes superoxide dismutase, catalase, and the intracellular levels of glutathione.	Curcumin	10-18	catalase	Mus musculus	173-181
28780751-9	2018	Our computational study suggests that although curcumin to some extent binds with Tp receptor, yet the inhibition of Arf6GDP to Arf6GTP conversion appeared to be an important mechanism by which curcumin inhibits U46619-induced increase in PLD activity in PASMCs.	Curcumin	194-202	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	239-242
27957686-6	2018	Overall, our findings demonstrate for the first time, a potential role for curcumin for treating polymyxin-induced neurotoxicity through the modulation of NF-kappaB signaling and its potent anti-oxidative and anti-apoptotic effects.	Curcumin	75-83	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	155-164
29972106-0	2018	Role of Curcumin in Regulation of TNF-alpha Mediated Brain Inflammatory Responses.	Curcumin	8-16	tumor necrosis factor	Homo sapiens	34-43
27966075-0	2018	Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus Striatum.	Curcumin	21-29	protein phosphatase 1, regulatory (inhibitor) subunit 1B	Rattus norvegicus	49-56
29115468-4	2018	The results demonstrated that curcumin treatment markedly decreased the blood glucose levels, plasma malondialdehyde concentration and plasma activity of glutathione peroxidase (GSH-Px) and catalase (CAT); however, it increased the plasma superoxide dismutase (SOD) and insulin levels.	Curcumin	30-38	catalase	Rattus norvegicus	190-198
29115468-4	2018	The results demonstrated that curcumin treatment markedly decreased the blood glucose levels, plasma malondialdehyde concentration and plasma activity of glutathione peroxidase (GSH-Px) and catalase (CAT); however, it increased the plasma superoxide dismutase (SOD) and insulin levels.	Curcumin	30-38	catalase	Rattus norvegicus	200-203
29115468-4	2018	The results demonstrated that curcumin treatment markedly decreased the blood glucose levels, plasma malondialdehyde concentration and plasma activity of glutathione peroxidase (GSH-Px) and catalase (CAT); however, it increased the plasma superoxide dismutase (SOD) and insulin levels.	Curcumin	30-38	superoxide dismutase 1	Rattus norvegicus	261-264
29115468-5	2018	Curcumin treatment increased the expression of the CAT, GSH-Px, HO-1 and norvegicus NAD(P)H quinone dehydrogenase 1, and decreased the SOD1 expression, which, led to a diminished oxidative stress status.	Curcumin	0-8	catalase	Rattus norvegicus	51-54
29115468-5	2018	Curcumin treatment increased the expression of the CAT, GSH-Px, HO-1 and norvegicus NAD(P)H quinone dehydrogenase 1, and decreased the SOD1 expression, which, led to a diminished oxidative stress status.	Curcumin	0-8	superoxide dismutase 1	Rattus norvegicus	135-139
29115468-6	2018	In addition, curcumin treatment significantly increased the protein expression of Keap1 in the Diab-Cur group when compared with the DC group, decreased cytosolic concentrations of Nrf2 while increasing nuclear accumulation of Nrf2.	Curcumin	13-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	181-185
29115468-6	2018	In addition, curcumin treatment significantly increased the protein expression of Keap1 in the Diab-Cur group when compared with the DC group, decreased cytosolic concentrations of Nrf2 while increasing nuclear accumulation of Nrf2.	Curcumin	13-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	227-231
29115468-7	2018	The results provide evidence that oxidative stress in the STZ-induced diabetic rat model may be attenuated by curcumin via the activation of the Keap1-Nrf2-ARE signaling pathway, as evidenced by a decrease in the blood glucose concentration and an increase in the transcription of several antioxidant genes.	Curcumin	110-118	NFE2 like bZIP transcription factor 2	Rattus norvegicus	151-155
29451216-10	2018	Curcumin and EGCG alone or in combination increased axonal sprouting, decreased glial scar formation, and altered the levels of macrophage inflammatory protein 1-alpha, interleukin-1beta, interleukin-4 and interleukin-6 cytokines.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	169-186
29451216-10	2018	Curcumin and EGCG alone or in combination increased axonal sprouting, decreased glial scar formation, and altered the levels of macrophage inflammatory protein 1-alpha, interleukin-1beta, interleukin-4 and interleukin-6 cytokines.	Curcumin	0-8	interleukin 6	Rattus norvegicus	206-219
29597206-16	2018	We also discovered that curcumin had an antiapoptotic effect by upregulating the expression of Bcl-2 and downregulating the expression of Bax in the retina of diabetic rats.	Curcumin	24-32	BCL2, apoptosis regulator	Rattus norvegicus	95-100
29972106-7	2018	OBJECTIVE: The study aims to elucidate the role of curcumin in alleviating the inflammatory reactions initiated by TNF-alpha and NF-kappab signaling.	Curcumin	51-59	nuclear factor kappa B subunit 1	Homo sapiens	129-138
27966075-12	2018	The results exhibit that curcumin modulates BDNF/DARPP32/CREB in arsenic-induced alterations in dopaminergic signaling in rat corpus striatum.	Curcumin	25-33	protein phosphatase 1, regulatory (inhibitor) subunit 1B	Rattus norvegicus	49-56
29972106-7	2018	OBJECTIVE: The study aims to elucidate the role of curcumin in alleviating the inflammatory reactions initiated by TNF-alpha and NF-kappab signaling.	Curcumin	51-59	tumor necrosis factor	Homo sapiens	115-124
29333130-3	2017	Here, curcumin, flavokawain B, and alpinetin were docked against the crystal structure of R273H mutant p53 in silico.	Curcumin	6-14	tumor protein p53	Homo sapiens	103-106
29484222-10	2018	In all treatment groups Bax, Cas-3 decreased compared to cisplatin group however Bcl-2 decreased in the curcumin and vitamin E groups.	Curcumin	104-112	BCL2, apoptosis regulator	Rattus norvegicus	81-86
29273065-0	2017	Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	84-87
29273065-14	2017	CONCLUSION: Pre-treatment with curcumin followed by 5-Fu may mediate autophagy turnover both in vitro and in vivo via AMPK/ULK1-dependent autophagy inhibition and AKT modulation, which may account for the increased susceptibility of the colon cancer cells/xenograft to the cytotoxicity of 5-Fu.	Curcumin	31-39	AKT serine/threonine kinase 1	Homo sapiens	163-166
29283372-11	2017	Further mechanistic study demonstrated that curcumin-Cu(II) or -Zn(II) complexes systems inhibited cell apoptosis via downregulating the nuclear factor kappaB (NF-kappaB) pathway and upregulating Bcl-2/Bax pathway.	Curcumin	44-52	BCL2, apoptosis regulator	Rattus norvegicus	196-201
29259894-9	2017	Curcumin inhibited LRP6 phosphorylation and nuclear accumulation of beta-catenin.	Curcumin	0-8	LDL receptor related protein 6	Rattus norvegicus	19-23
29259894-11	2017	Meanwhile curcumin suppressed suture-induced CNV and inhibited LRP6 phosphorylation as well as beta-catenin accumulation in SD rats.	Curcumin	10-18	LDL receptor related protein 6	Rattus norvegicus	63-67
29312505-0	2017	Curcumin inhibits gastric cancer-derived mesenchymal stem cells mediated angiogenesis by regulating NF-kappaB/VEGF signaling.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	110-114
29312505-6	2017	Furthermore, it was noticed that curcumin abrogated NF-kappaB signaling activity and VEGF production in GC-MSCs.	Curcumin	33-41	vascular endothelial growth factor A	Homo sapiens	85-89
29312505-7	2017	Next, to establish the link between regulation of NF-kappaB/VEGF signaling by curcumin, and its influence on GC-MSC-derived angiogenesis, we pretreated GC-MSCs with either NF-kappaB inhibitor PDTC or a neutralizing antibody against VEGF (NA-VEGF), and then collected conditioned media (CM).	Curcumin	78-86	vascular endothelial growth factor A	Homo sapiens	60-64
29312505-11	2017	Overall, our study indicated that curcumin may serve as a novel therapeutic target for GC-MSCs derived angiogenesis, by inhibiting NF-kappaB/VEGF signaling.	Curcumin	34-42	vascular endothelial growth factor A	Homo sapiens	141-145
29312508-0	2017	Curcumin combined with glycyrrhetinic acid inhibits the development of hepatocellular carcinoma cells by down-regulating the PTEN/PI3K/AKT signalling pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	135-138
29312508-10	2017	Moreover, by knocking down the expression of PTEN, we confirmed that curcumin and GA exert their anticancer effects by inhibiting the PTEN/PI3K/Akt signalling pathway.	Curcumin	69-77	AKT serine/threonine kinase 1	Homo sapiens	144-147
29312508-11	2017	Collectively, these results indicate that the combination of curcumin and GA could effectively inhibit the development of HepG2 cells by inhibiting PTEN/PI3K/Akt signalling and could be a promising treatment strategy for patients with HCC.	Curcumin	61-69	AKT serine/threonine kinase 1	Homo sapiens	158-161
29031698-5	2017	The multiple-ring compounds, EGCG, resveratrol, and curcumin, redirect Abeta(17-36) from a fibrillar aggregate to an unstructured oligomer.	Curcumin	52-60	amyloid beta precursor protein	Homo sapiens	71-76
29031698-8	2017	The rank order of inhibitory effectiveness of Abeta(17-36) aggregation is as follows: EGCG &gt; resveratrol &gt; curcumin &gt; vanillin, consistent with experimental findings on inhibiting full-length Abeta fibrillation.	Curcumin	113-121	amyloid beta precursor protein	Homo sapiens	46-51
29333130-4	2017	Consequently, all the compounds bind to the cavity of R273H mutant p53 with a dissociation constant estimated to have 36.57, 70.77, and 75.11 microM for curcumin, flavokawain B, and alpinetin, respectively.	Curcumin	153-161	tumor protein p53	Homo sapiens	67-70
29187453-6	2017	RESULTS: Rau 015 (15 muM) and curcumin (112.5 muM) significantly reduced MCF-7, MDA-MB-231 and MG-63 cell proliferation compared to individual treatment, indicating synergistic anti-proliferative effects.	Curcumin	30-38	latexin	Homo sapiens	46-49
29110611-13	2017	Further study showed curcumin induced cell cycle arrest by activating G2 checkpoint through p53 pathway.	Curcumin	21-29	tumor protein p53	Homo sapiens	92-95
29110611-14	2017	Meanwhile, we found that curcumin suppressed the AKT, MAPK and TGF-beta pathways in RPE cells which may also affect proliferation and EMT.	Curcumin	25-33	AKT serine/threonine kinase 1	Homo sapiens	49-52
29110611-14	2017	Meanwhile, we found that curcumin suppressed the AKT, MAPK and TGF-beta pathways in RPE cells which may also affect proliferation and EMT.	Curcumin	25-33	transforming growth factor beta 1	Homo sapiens	63-71
29187453-7	2017	Rau 018 (30 muM) and curcumin (100 muM) displayed similar effects in MCF-7 and MG-63 cells.	Curcumin	21-29	latexin	Homo sapiens	35-38
29268977-0	2017	Reverse effect of curcumin on CDDP-induced drug-resistance via Keap1/p62-Nrf2 signaling in A549/CDDP cell.	Curcumin	18-26	kelch like ECH associated protein 1	Homo sapiens	63-68
29268977-0	2017	Reverse effect of curcumin on CDDP-induced drug-resistance via Keap1/p62-Nrf2 signaling in A549/CDDP cell.	Curcumin	18-26	NFE2 like bZIP transcription factor 2	Homo sapiens	73-77
29268977-6	2017	Meanwhile, curcumin combination attenuated autophagy and Nrf2 activation induced by CDDP, and reversed the drug-resistant phenotype.	Curcumin	11-19	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
29268977-7	2017	Notably, curcumin combination augmented Keap1 transcription.	Curcumin	9-17	kelch like ECH associated protein 1	Homo sapiens	40-45
29268977-8	2017	Furthermore, Keap1 ablation with short hairpin RNAs hampered the efficacy of curcumin, suggesting Keap1 played a crucial role on reversal effect of curcumin.	Curcumin	77-85	kelch like ECH associated protein 1	Homo sapiens	13-18
29268977-8	2017	Furthermore, Keap1 ablation with short hairpin RNAs hampered the efficacy of curcumin, suggesting Keap1 played a crucial role on reversal effect of curcumin.	Curcumin	77-85	kelch like ECH associated protein 1	Homo sapiens	98-103
29268977-8	2017	Furthermore, Keap1 ablation with short hairpin RNAs hampered the efficacy of curcumin, suggesting Keap1 played a crucial role on reversal effect of curcumin.	Curcumin	148-156	kelch like ECH associated protein 1	Homo sapiens	13-18
29268977-8	2017	Furthermore, Keap1 ablation with short hairpin RNAs hampered the efficacy of curcumin, suggesting Keap1 played a crucial role on reversal effect of curcumin.	Curcumin	148-156	kelch like ECH associated protein 1	Homo sapiens	98-103
29268977-10	2017	Curcumin attenuates this process and combat drug-resistance through its potent activation on Keap1 transcription, which is essential for interplay between oxidative stress induced Nrf2 activation and autophagy/apoptosis switch.	Curcumin	0-8	kelch like ECH associated protein 1	Homo sapiens	93-98
29268977-10	2017	Curcumin attenuates this process and combat drug-resistance through its potent activation on Keap1 transcription, which is essential for interplay between oxidative stress induced Nrf2 activation and autophagy/apoptosis switch.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	180-184
28950235-4	2017	Recent studies revealed that only two scaffolds i.e. triazinone and curcumin act as a dual inhibitor against BACE-1 and GSK-3beta.	Curcumin	68-76	beta-secretase 1	Homo sapiens	109-115
29285156-7	2017	The results also indicated that curcumin reversed this effect by promoting autophagy through the phosphoinositide 3-kinase/AKT serine/threonine kinase signaling pathway.	Curcumin	32-40	AKT serine/threonine kinase 1	Rattus norvegicus	123-126
29285138-7	2017	Moreover, the results of immunohistochemical analysis indicated that the expression levels of histone deacetylase 1 (HDAC1), matrix metalloproteinase-2 (MMP-2) and transforming growth factor beta (TGFbeta) decreased in the curcumin treatment group, compared with the non-treated group or the negative control group.	Curcumin	223-231	transforming growth factor, beta 1	Rattus norvegicus	197-204
31966505-7	2017	Bcl-2-associated X protein (Bax) expression was promoted and B-cell lymphoma-2 (Bcl-2) expression was suppressed, In addition, Notch1, Notch1 intracellular domain (NICD1) and hairy and enhancer of split 1 (Hes-1) were decreased dramatically in HT29 cells treated with Cur combined with DDP.	Curcumin	268-271	BCL2 associated X, apoptosis regulator	Homo sapiens	0-26
29080841-0	2017	Mitochondrial targeted curcumin exhibits anticancer effects through disruption of mitochondrial redox and modulation of TrxR2 activity.	Curcumin	23-31	thioredoxin reductase 2	Homo sapiens	120-125
31966505-7	2017	Bcl-2-associated X protein (Bax) expression was promoted and B-cell lymphoma-2 (Bcl-2) expression was suppressed, In addition, Notch1, Notch1 intracellular domain (NICD1) and hairy and enhancer of split 1 (Hes-1) were decreased dramatically in HT29 cells treated with Cur combined with DDP.	Curcumin	268-271	BCL2 apoptosis regulator	Homo sapiens	0-5
31966505-9	2017	It showed that DDP combined with Cur promote the apoptosis of HT29 cells via regulating the expression of related apoptotic genes and inhibiting the activation of Notch1 signaling pathway.	Curcumin	33-36	notch receptor 1	Homo sapiens	163-169
28264607-7	2017	RESULTS AND DISCUSSION: Curcumin efficiently inhibited LPS-induced cytokines (TNF-alpha, IL-6) and microRNA-155 (miR-155) expression (p &lt; 0.05) without affecting the normally growth of Raw264.7 and THP-1 cells (IC50 21.8 and 22.3 muM at 48 h, respectively).	Curcumin	24-32	tumor necrosis factor	Mus musculus	78-87
28839007-3	2017	We investigated the effect of curcumin, a naturally occurring polyphenol known for its anti-inflammatory properties and inhibitory action on 11beta-HSD1 activity, on preserving metabolic health and limiting adipose tissue growth following the cessation of daily exercise and caloric restriction (CR).	Curcumin	30-38	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	141-152
28839007-9	2017	Curcumin reduced insulin AUC, HOMA-IR, and CRP vs. the placebo group (all P &lt; 0.05).	Curcumin	0-8	C-reactive protein	Rattus norvegicus	43-46
28839007-13	2017	In this paper, we examined the metabolic implications of curcumin, a compound known for its anti-inflammatory properties and inhibitory action on the enzyme 11beta-HSD1, in a rodent model of adiposity rebound after the cessation of diet and exercise.	Curcumin	57-65	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	157-168
27897077-1	2017	Acetylcholinesterase (AChE) is an important enzyme responsible for Alzheimer"s disease, as per report, keto-enol form of curcumin inhibits this enzyme.	Curcumin	121-129	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
27897077-1	2017	Acetylcholinesterase (AChE) is an important enzyme responsible for Alzheimer"s disease, as per report, keto-enol form of curcumin inhibits this enzyme.	Curcumin	121-129	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
28861684-0	2017	Curcumin revitalizes Amyloid beta (25-35)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	159-163
28861684-8	2017	While curcumin pretreatment resulted in upregulation of iNOS and Nrf2 proteins.	Curcumin	6-14	nitric oxide synthase 2	Homo sapiens	56-60
28861684-8	2017	While curcumin pretreatment resulted in upregulation of iNOS and Nrf2 proteins.	Curcumin	6-14	NFE2 like bZIP transcription factor 2	Homo sapiens	65-69
28861684-10	2017	In this study, pretreatment of curcumin to the SH-SY5Y cells enhanced the expression of DNA repair enzymes APE1, pol beta, and PARP1 enzymes to counter the oxidative DNA base damage via base excision repair (BER) pathway, and also activated the antioxidant element (ARE) via Nrf2 upregulation.	Curcumin	31-39	poly(ADP-ribose) polymerase 1	Homo sapiens	127-132
28861684-10	2017	In this study, pretreatment of curcumin to the SH-SY5Y cells enhanced the expression of DNA repair enzymes APE1, pol beta, and PARP1 enzymes to counter the oxidative DNA base damage via base excision repair (BER) pathway, and also activated the antioxidant element (ARE) via Nrf2 upregulation.	Curcumin	31-39	NFE2 like bZIP transcription factor 2	Homo sapiens	275-279
28264607-7	2017	RESULTS AND DISCUSSION: Curcumin efficiently inhibited LPS-induced cytokines (TNF-alpha, IL-6) and microRNA-155 (miR-155) expression (p &lt; 0.05) without affecting the normally growth of Raw264.7 and THP-1 cells (IC50 21.8 and 22.3 muM at 48 h, respectively).	Curcumin	24-32	interleukin 6	Mus musculus	89-93
29278024-0	2017	Curcumin regulates intracellular calcium release and inhibits oxidative stress parameters, VEGF, and caspase-3/-9 levels in human retinal pigment epithelium cells.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	91-95
29278024-0	2017	Curcumin regulates intracellular calcium release and inhibits oxidative stress parameters, VEGF, and caspase-3/-9 levels in human retinal pigment epithelium cells.	Curcumin	0-8	caspase 3	Homo sapiens	101-113
28628927-10	2017	Both curcumin and MyD88 siRNA inhibited the mRNA expression of MyD88 pathway-related effectors (TLR2, TLR4, NF-kappaB, TNF-alpha, IL-1beta) in HSC.	Curcumin	5-13	toll-like receptor 2	Rattus norvegicus	96-100
29172279-0	2017	Anti-Vascular Endothelial Growth Factor Targeting by Curcumin and Thalidomide in Acute Myeloid Leukemia Cells Acute myeloid leukemias (AMLs) are blood disorders that exhibit uncontrolled growth and reduction of apoptosisrates.	Curcumin	53-61	vascular endothelial growth factor A	Homo sapiens	5-39
28628927-10	2017	Both curcumin and MyD88 siRNA inhibited the mRNA expression of MyD88 pathway-related effectors (TLR2, TLR4, NF-kappaB, TNF-alpha, IL-1beta) in HSC.	Curcumin	5-13	toll-like receptor 4	Rattus norvegicus	102-106
28628927-10	2017	Both curcumin and MyD88 siRNA inhibited the mRNA expression of MyD88 pathway-related effectors (TLR2, TLR4, NF-kappaB, TNF-alpha, IL-1beta) in HSC.	Curcumin	5-13	tumor necrosis factor	Rattus norvegicus	119-128
28628927-10	2017	Both curcumin and MyD88 siRNA inhibited the mRNA expression of MyD88 pathway-related effectors (TLR2, TLR4, NF-kappaB, TNF-alpha, IL-1beta) in HSC.	Curcumin	5-13	interleukin 1 beta	Rattus norvegicus	130-138
29551922-9	2017	In comparison with the normal control group in the same period, we found that the content of FFAs and TNF-alpha in serum of rats of the model group were elevated significantly, and the differences had statistical significance (p &lt; .05 or .01); the levels in the curcumin group were significantly decreased in comparison with the model group in the same period, and the difference had statistical significance (p &lt; .05 or .01).	Curcumin	265-273	tumor necrosis factor	Rattus norvegicus	102-111
29551922-12	2017	Thus, we inferred that the mechanism of curcumin to improve the insulin resistance might be correlated with the decreases of FFA and TNF-alpha in serum.	Curcumin	40-48	tumor necrosis factor	Rattus norvegicus	133-142
29225427-0	2017	Molecular docking analysis of curcumin analogues with COX-2.	Curcumin	30-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
29225427-1	2017	Curcumin analogues were evaluated for COX-2 inhibitory as anti-inflammatory activities.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
29225427-5	2017	Molecular docking study revealed the binding orientations of curcumin analogues in the active sites of COX-2 towards the design of potent inhibitors.	Curcumin	61-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
29172279-5	2017	As a new strategy we here evaluated anti-VEGF properties of curcumin, alone and in combination with thalidomide, in leukemic cell lines.	Curcumin	60-68	vascular endothelial growth factor A	Homo sapiens	41-45
29172279-8	2017	In KG-1 cells, thelevel of VEGF (A, B, C and D) mRNA was decreased in curcumin-treated as compared to untreated cells.	Curcumin	70-78	vascular endothelial growth factor A	Homo sapiens	27-46
29184483-6	2017	H3K9ac regulates MCT1 expression was confirmed by HDAC acetyltransferase inhibitors trichostatin A and curcumin.	Curcumin	103-111	solute carrier family 16 member 1	Homo sapiens	17-21
29312546-0	2017	Curcumin downregulates the expression of Snail via suppressing Smad2 pathway to inhibit TGF-beta1-induced epithelial-mesenchymal transitions in hepatoma cells.	Curcumin	0-8	snail family transcriptional repressor 1	Homo sapiens	41-46
29312546-0	2017	Curcumin downregulates the expression of Snail via suppressing Smad2 pathway to inhibit TGF-beta1-induced epithelial-mesenchymal transitions in hepatoma cells.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	88-97
29312546-6	2017	Fortunately, in this study, we found that curcumin inhibited TGF-beta1-induced EMT in hepatoma cells.	Curcumin	42-50	transforming growth factor beta 1	Homo sapiens	61-70
29312546-7	2017	Furthermore, we demonstrated that curcumin inhibited TGF-beta1-induced EMT via inhibiting Smad2 phosphorylation and nuclear translocation, then suppressing Smad2 combined with the promoter of Snail which inhibited the transcriptional expression of Snail.	Curcumin	34-42	transforming growth factor beta 1	Homo sapiens	53-62
29312546-7	2017	Furthermore, we demonstrated that curcumin inhibited TGF-beta1-induced EMT via inhibiting Smad2 phosphorylation and nuclear translocation, then suppressing Smad2 combined with the promoter of Snail which inhibited the transcriptional expression of Snail.	Curcumin	34-42	snail family transcriptional repressor 1	Homo sapiens	192-197
29312546-7	2017	Furthermore, we demonstrated that curcumin inhibited TGF-beta1-induced EMT via inhibiting Smad2 phosphorylation and nuclear translocation, then suppressing Smad2 combined with the promoter of Snail which inhibited the transcriptional expression of Snail.	Curcumin	34-42	snail family transcriptional repressor 1	Homo sapiens	248-253
29180881-0	2017	Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-kappaB/COX-2 signaling pathways.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	104-107
29180881-0	2017	Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-kappaB/COX-2 signaling pathways.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	112-121
29180881-0	2017	Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-kappaB/COX-2 signaling pathways.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
29180881-6	2017	In addition, co-treatment with curcumin increased ACNU-induced apoptosis through enhancing the release of cytochrome c from the mitochondrial intermembrane space into the cytosol.	Curcumin	31-39	cytochrome c, somatic	Homo sapiens	106-118
29180881-7	2017	Further, curcumin and ACNU acted synergistically in their antitumor effects by targeting N-cadherin/MMP2/9, PI3K/AKT, and NF-kappaB/COX-2 signaling.	Curcumin	9-17	AKT serine/threonine kinase 1	Homo sapiens	113-116
29180881-7	2017	Further, curcumin and ACNU acted synergistically in their antitumor effects by targeting N-cadherin/MMP2/9, PI3K/AKT, and NF-kappaB/COX-2 signaling.	Curcumin	9-17	nuclear factor kappa B subunit 1	Homo sapiens	122-131
29180881-7	2017	Further, curcumin and ACNU acted synergistically in their antitumor effects by targeting N-cadherin/MMP2/9, PI3K/AKT, and NF-kappaB/COX-2 signaling.	Curcumin	9-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
29052674-4	2017	Here, we demonstrate that epidermal growth factor receptor (EGFR)-targeting GE11 peptides conjugated with PEGylated polylactic-co-glycolic acid (PLGA) nanoparticles can be used to effectively deliver an anti-cancer agent, curcumin, into EGFR-expressing MCF-7 cells in vitro and in vivo.	Curcumin	222-230	epidermal growth factor receptor	Homo sapiens	26-58
28802718-8	2017	In vitro, curcumin inhibited TNF-alpha production by monocytes and reduced the circulating TNF-alpha levels.	Curcumin	10-18	tumor necrosis factor	Rattus norvegicus	29-38
28802718-8	2017	In vitro, curcumin inhibited TNF-alpha production by monocytes and reduced the circulating TNF-alpha levels.	Curcumin	10-18	tumor necrosis factor	Rattus norvegicus	91-100
29052674-4	2017	Here, we demonstrate that epidermal growth factor receptor (EGFR)-targeting GE11 peptides conjugated with PEGylated polylactic-co-glycolic acid (PLGA) nanoparticles can be used to effectively deliver an anti-cancer agent, curcumin, into EGFR-expressing MCF-7 cells in vitro and in vivo.	Curcumin	222-230	epidermal growth factor receptor	Homo sapiens	60-64
28926928-7	2017	Furthermore, we found that ROS-dependent HIF-1alpha and its downstream proteins also play an important role on Curcumin induced apoptosis.	Curcumin	111-119	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-51
28826090-0	2017	Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells.	Curcumin	32-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
28826090-7	2017	Curcumin increased Nrf2 expression and nuclear translocation, and its binding activity to DNA, which might be associated with suppression of Kelch-like ECH-associated protein 1 in HSCs.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23
28826090-8	2017	Of interest was that Nrf2 overexpression plasmids, in contract to Nrf2 siRNA, strengthened the effect of curcumin on induction of lipocyte phenotype.	Curcumin	105-113	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
28826090-8	2017	Of interest was that Nrf2 overexpression plasmids, in contract to Nrf2 siRNA, strengthened the effect of curcumin on induction of lipocyte phenotype.	Curcumin	105-113	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70
28826090-10	2017	Noteworthily, Nrf2 knockdown abolished the protective effect of curcumin.	Curcumin	64-72	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
28826090-11	2017	In conclusion, curcumin could induce lipocyte phenotype of activated HSCs via activating Nrf2.	Curcumin	15-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	89-93
29568434-5	2017	Herein, we demonstrated that tuning the stereo-hindrance of the phenoxy-alkyl chains at the 4-position of a curcumin scaffold could lead to certain selectivity for sAbeta over insoluble Abetas (insAbeta).	Curcumin	108-116	SH3-domain binding protein 5 (BTK-associated)	Mus musculus	164-170
28904007-0	2017	Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance-Linked ATP-Binding Cassette Transporter ABCG2.	Curcumin	21-29	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	116-121
28951138-0	2017	Curcumin attenuates skeletal muscle mitochondrial impairment in COPD rats: PGC-1alpha/SIRT3 pathway involved.	Curcumin	0-8	PPARG coactivator 1 alpha	Rattus norvegicus	75-85
28951138-7	2017	Moreover, curcumin significantly decreased oxidative stress and inflammation by determining the levels of malondialdehyde, manganese superoxide dismutase, glutathione peroxidase, catalase, IL-6 and TNF-alpha in skeletal muscle of COPD rats.	Curcumin	10-18	catalase	Rattus norvegicus	179-187
28951138-7	2017	Moreover, curcumin significantly decreased oxidative stress and inflammation by determining the levels of malondialdehyde, manganese superoxide dismutase, glutathione peroxidase, catalase, IL-6 and TNF-alpha in skeletal muscle of COPD rats.	Curcumin	10-18	interleukin 6	Rattus norvegicus	189-193
28994313-0	2017	TRAIL and curcumin codelivery nanoparticles enhance TRAIL-induced apoptosis through upregulation of death receptors.	Curcumin	10-18	TNF superfamily member 10	Homo sapiens	52-57
28951138-7	2017	Moreover, curcumin significantly decreased oxidative stress and inflammation by determining the levels of malondialdehyde, manganese superoxide dismutase, glutathione peroxidase, catalase, IL-6 and TNF-alpha in skeletal muscle of COPD rats.	Curcumin	10-18	tumor necrosis factor	Rattus norvegicus	198-207
28951138-8	2017	Furthermore, curcumin significantly increased the mRNA and protein expression of PGC-1alpha and SIRT3 in the skeletal muscle tissues of COPD rats.	Curcumin	13-21	PPARG coactivator 1 alpha	Rattus norvegicus	81-91
28951138-9	2017	These results suggested that curcumin can attenuate skeletal muscle mitochondrial impairment in COPD rats possibly by the up-regulation of PGC-1alpha/SIRT3 signaling pathway.	Curcumin	29-37	PPARG coactivator 1 alpha	Rattus norvegicus	139-149
28904007-2	2017	Previous studies have shown that curcumin, a natural product and a dietary constituent of turmeric, inhibits the function of MDR-related ABC transporters, including ABCB1, ABCC1, and especially ABCG2.	Curcumin	33-41	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	194-199
28904007-4	2017	In this study, we investigated the effects of 24 synthetic curcumin analogs with increased bioavailability on the transport function of ABCG2.	Curcumin	59-67	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	136-141
28904007-5	2017	The screening of the 24 synthetic analogs by means of flow cytometry revealed that four of the curcumin analogs (GO-Y030, GO-Y078, GO-Y168, and GO-Y172) significantly inhibited the efflux of the ABCG2 substrates, mitoxantrone and pheophorbide A, from ABCG2-overexpressing K562/breast cancer resistance protein (BCRP) cells.	Curcumin	95-103	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	195-200
28904007-5	2017	The screening of the 24 synthetic analogs by means of flow cytometry revealed that four of the curcumin analogs (GO-Y030, GO-Y078, GO-Y168, and GO-Y172) significantly inhibited the efflux of the ABCG2 substrates, mitoxantrone and pheophorbide A, from ABCG2-overexpressing K562/breast cancer resistance protein (BCRP) cells.	Curcumin	95-103	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	251-256
28904007-5	2017	The screening of the 24 synthetic analogs by means of flow cytometry revealed that four of the curcumin analogs (GO-Y030, GO-Y078, GO-Y168, and GO-Y172) significantly inhibited the efflux of the ABCG2 substrates, mitoxantrone and pheophorbide A, from ABCG2-overexpressing K562/breast cancer resistance protein (BCRP) cells.	Curcumin	95-103	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	272-309
28904007-5	2017	The screening of the 24 synthetic analogs by means of flow cytometry revealed that four of the curcumin analogs (GO-Y030, GO-Y078, GO-Y168, and GO-Y172) significantly inhibited the efflux of the ABCG2 substrates, mitoxantrone and pheophorbide A, from ABCG2-overexpressing K562/breast cancer resistance protein (BCRP) cells.	Curcumin	95-103	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	311-315
28904007-8	2017	Taken together, these results suggest that nontoxic synthetic curcumin analogs with increased bioavailability, especially GO-Y030 and GO-Y078, inhibit the function of ABCG2 by directly interacting at the substrate-binding site.	Curcumin	62-70	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	167-172
28904007-9	2017	These synthetic curcumin analogs could therefore be developed as potent modulators to overcome ABCG2-mediated MDR in cancer cells.	Curcumin	16-24	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	95-100
29201217-8	2017	Treatment with 10 microM curcumin for 48 h also significantly reduced the phosphorylation levels of mechanistic target of rapamycin (mTOR), ribosomal protein S6, phosphoinositide 3-kinase and AKT (protein kinase B) in A549 and H1299 cells (P&lt;0.05).	Curcumin	25-33	mechanistic target of rapamycin kinase	Homo sapiens	100-131
29201217-8	2017	Treatment with 10 microM curcumin for 48 h also significantly reduced the phosphorylation levels of mechanistic target of rapamycin (mTOR), ribosomal protein S6, phosphoinositide 3-kinase and AKT (protein kinase B) in A549 and H1299 cells (P&lt;0.05).	Curcumin	25-33	mechanistic target of rapamycin kinase	Homo sapiens	133-137
29201217-8	2017	Treatment with 10 microM curcumin for 48 h also significantly reduced the phosphorylation levels of mechanistic target of rapamycin (mTOR), ribosomal protein S6, phosphoinositide 3-kinase and AKT (protein kinase B) in A549 and H1299 cells (P&lt;0.05).	Curcumin	25-33	AKT serine/threonine kinase 1	Homo sapiens	192-195
29201217-9	2017	These data indicated that curcumin enhanced autophagy and apoptosis in NSCLC cells by acting as an mTOR complex1/2 inhibitor.	Curcumin	26-34	mechanistic target of rapamycin kinase	Homo sapiens	99-103
29578200-10	2017	Results: EGCG and curcumin at 10 muM concentration reversed EMT, inhibited proliferation and migration through Smad-3 phosphorylation, when induced by TGF-beta1 in ARPE-19 cells.	Curcumin	18-26	transforming growth factor beta 1	Homo sapiens	151-160
28739530-4	2017	Human umbilical vein endothelial cells (HUVECs) were exposed to curcumin (0.5-1muM) for 3h prior to their activation by Tumor Necrosis Factor alpha (TNF-alpha).	Curcumin	64-72	latexin	Homo sapiens	79-82
28739530-4	2017	Human umbilical vein endothelial cells (HUVECs) were exposed to curcumin (0.5-1muM) for 3h prior to their activation by Tumor Necrosis Factor alpha (TNF-alpha).	Curcumin	64-72	tumor necrosis factor	Homo sapiens	120-147
28739530-4	2017	Human umbilical vein endothelial cells (HUVECs) were exposed to curcumin (0.5-1muM) for 3h prior to their activation by Tumor Necrosis Factor alpha (TNF-alpha).	Curcumin	64-72	tumor necrosis factor	Homo sapiens	149-158
28739530-8	2017	Curcumin also prevented changes in both endothelial permeability and the area of HUVECs when induced by TNF-alpha.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	104-113
29578200-0	2017	Epigallocatechin gallate &amp; curcumin prevent transforming growth factor beta 1-induced epithelial to mesenchymal transition in ARPE-19 cells.	Curcumin	31-39	transforming growth factor beta 1	Homo sapiens	48-81
29578200-4	2017	This study was aimed to evaluate the anti-EMT properties of bio-active compounds epigallocatechin gallate (EGCG), curcumin and lycopene as inhibitors of EMT induced by transforming growth factor beta 1 (TGF-beta1) in cultured ARPE-19 cells.	Curcumin	114-122	transforming growth factor beta 1	Homo sapiens	168-201
29578200-12	2017	Interpretation &amp; conclusions: EGCG and curcumin are potent in preventing EMT induced by TGF-beta1 in ARPE-19 cells and therefore, proposed as potential molecules for further pre-clinical evaluation in PVR management.	Curcumin	43-51	transforming growth factor beta 1	Homo sapiens	92-101
29578200-4	2017	This study was aimed to evaluate the anti-EMT properties of bio-active compounds epigallocatechin gallate (EGCG), curcumin and lycopene as inhibitors of EMT induced by transforming growth factor beta 1 (TGF-beta1) in cultured ARPE-19 cells.	Curcumin	114-122	transforming growth factor beta 1	Homo sapiens	203-212
29142607-0	2017	Curcumin inhibits MCF-7 cells by modulating the NF-kappaB signaling pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	48-57
29048630-6	2017	Expression levels of TGF-alpha and TGFbeta1 genes were upregulated in MCF-10F and downregulated in Tumor2 cell lines treated with curcumin.	Curcumin	130-138	transforming growth factor beta 1	Homo sapiens	35-43
27667581-4	2017	The stability of the complexes of COX-1, COX-2, Topo I, Topo IIbeta and aromatase with the most potent inhibitor curcumin and those of the respective drugs, namely ibuprofen, aspirin, topotecan, etoposide, and exemestane were also analyzed through MD simulation analyses which revealed better stability of curcumin complexes than those of respective drugs.	Curcumin	113-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46
28901458-0	2017	Neuroprotective effects of curcumin alleviate lumbar intervertebral disc degeneration through regulating the expression of iNOS, COX-2, TGF-beta1/2, MMP-9 and BDNF in a rat model.	Curcumin	27-35	nitric oxide synthase 2	Rattus norvegicus	123-127
28901458-3	2017	The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, transforming growth factor (TGF)-beta1/2, matrix metalloproteinase (MMP)-9 and brain-derived neurotrophic factor (BDNF) in a rat model of LIDD.	Curcumin	56-64	nitric oxide synthase 2	Rattus norvegicus	121-152
28901458-3	2017	The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, transforming growth factor (TGF)-beta1/2, matrix metalloproteinase (MMP)-9 and brain-derived neurotrophic factor (BDNF) in a rat model of LIDD.	Curcumin	56-64	nitric oxide synthase 2	Rattus norvegicus	154-158
28901458-3	2017	The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, transforming growth factor (TGF)-beta1/2, matrix metalloproteinase (MMP)-9 and brain-derived neurotrophic factor (BDNF) in a rat model of LIDD.	Curcumin	56-64	transforming growth factor, beta 1	Rattus norvegicus	185-225
28901458-5	2017	It was revealed that treatment with curcumin significantly reduced interleukin (IL)-1beta and IL-6, iNOS, COX-2 and MMP-9 levels in rats with LIDD.	Curcumin	36-44	interleukin 1 beta	Rattus norvegicus	67-89
28901458-5	2017	It was revealed that treatment with curcumin significantly reduced interleukin (IL)-1beta and IL-6, iNOS, COX-2 and MMP-9 levels in rats with LIDD.	Curcumin	36-44	interleukin 6	Rattus norvegicus	94-98
28901458-5	2017	It was revealed that treatment with curcumin significantly reduced interleukin (IL)-1beta and IL-6, iNOS, COX-2 and MMP-9 levels in rats with LIDD.	Curcumin	36-44	nitric oxide synthase 2	Rattus norvegicus	100-104
28901458-6	2017	In addition, treatment with curcumin reduced the mRNA expression levels of TGF-beta1 and TGF-beta2, whereas it increased the mRNA expression levels of BDNF in rats with LIDD.	Curcumin	28-36	transforming growth factor, beta 1	Rattus norvegicus	75-84
28901458-7	2017	In conclusion, the present findings indicate that curcumin may exert protective effects on LIDD development, exerting its action through the regulation of iNOS, COX-2, TGF-beta1/2, MMP-9 and BDNF.	Curcumin	50-58	nitric oxide synthase 2	Rattus norvegicus	155-159
27989010-0	2017	Effect of curcumin on the expression of p53, transforming growth factor-beta, and inducible nitric oxide synthase in oral submucous fibrosis: A pilot study.	Curcumin	10-18	tumor protein p53	Homo sapiens	40-43
27989010-0	2017	Effect of curcumin on the expression of p53, transforming growth factor-beta, and inducible nitric oxide synthase in oral submucous fibrosis: A pilot study.	Curcumin	10-18	transforming growth factor beta 1	Homo sapiens	45-76
27989010-0	2017	Effect of curcumin on the expression of p53, transforming growth factor-beta, and inducible nitric oxide synthase in oral submucous fibrosis: A pilot study.	Curcumin	10-18	nitric oxide synthase 2	Homo sapiens	82-113
27989010-6	2017	After therapy with curcumin, a decrease in the expression of p53, TGF-beta, and iNOS was seen in 25%, 32.1%, and 32.1% of the samples, respectively; however, the difference in pretreatment and post-treatment expressions was not found to be statistically significant.	Curcumin	19-27	tumor protein p53	Homo sapiens	61-64
27989010-6	2017	After therapy with curcumin, a decrease in the expression of p53, TGF-beta, and iNOS was seen in 25%, 32.1%, and 32.1% of the samples, respectively; however, the difference in pretreatment and post-treatment expressions was not found to be statistically significant.	Curcumin	19-27	transforming growth factor beta 1	Homo sapiens	66-74
27989010-6	2017	After therapy with curcumin, a decrease in the expression of p53, TGF-beta, and iNOS was seen in 25%, 32.1%, and 32.1% of the samples, respectively; however, the difference in pretreatment and post-treatment expressions was not found to be statistically significant.	Curcumin	19-27	nitric oxide synthase 2	Homo sapiens	80-84
27989010-7	2017	CONCLUSION: The present finding suggest that curcumin could have an effect on the expression of p53, iNOS, and TGF-beta in OSMF, and thus, could prove to be an effective chemopreventive agent for its management.	Curcumin	45-53	tumor protein p53	Homo sapiens	96-99
27989010-7	2017	CONCLUSION: The present finding suggest that curcumin could have an effect on the expression of p53, iNOS, and TGF-beta in OSMF, and thus, could prove to be an effective chemopreventive agent for its management.	Curcumin	45-53	nitric oxide synthase 2	Homo sapiens	101-105
27989010-7	2017	CONCLUSION: The present finding suggest that curcumin could have an effect on the expression of p53, iNOS, and TGF-beta in OSMF, and thus, could prove to be an effective chemopreventive agent for its management.	Curcumin	45-53	transforming growth factor beta 1	Homo sapiens	111-119
29142607-8	2017	The data indicate that curcumin is able to inhibit breast cancer cell proliferation, possibly by regulating the NF-kappaB signaling pathway.	Curcumin	23-31	nuclear factor kappa B subunit 1	Homo sapiens	112-121
28736282-8	2017	Curcumin inhibited the proliferation of IMQ-induced differentiated HaCaT cells (Psoriatic-like cells) by down-regulation of pro-inflammatory cytokines, interleukin-17, tumor necrosis factor-alpha, interferon-gamma, and interleukin-6.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	152-195
29151957-0	2017	Curcumin Enhances the Anticancer Effect Of 5-fluorouracil against Gastric Cancer through Down-Regulation of COX-2 and NF- kappaB Signaling Pathways.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
29151957-11	2017	Furthermore, the protein expressions of COX-2 and NF-kappaB in MKN45 cells were decreased by 44.79% and 37.67%, 47.17% and 48.21%, 60.21% and 62.44%, respectively, after treatment of curcumin (25 mumol/l) and 5-FU (50 mumol/l) alone or in combination for 48 h. Curcumin also enhanced the anticancer activity of 5-FU without increasing toxicity in nude mice bearing MKN45 tumor xenografts in vivo.	Curcumin	183-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
29151957-11	2017	Furthermore, the protein expressions of COX-2 and NF-kappaB in MKN45 cells were decreased by 44.79% and 37.67%, 47.17% and 48.21%, 60.21% and 62.44%, respectively, after treatment of curcumin (25 mumol/l) and 5-FU (50 mumol/l) alone or in combination for 48 h. Curcumin also enhanced the anticancer activity of 5-FU without increasing toxicity in nude mice bearing MKN45 tumor xenografts in vivo.	Curcumin	183-191	nuclear factor kappa B subunit 1	Homo sapiens	50-59
29151957-11	2017	Furthermore, the protein expressions of COX-2 and NF-kappaB in MKN45 cells were decreased by 44.79% and 37.67%, 47.17% and 48.21%, 60.21% and 62.44%, respectively, after treatment of curcumin (25 mumol/l) and 5-FU (50 mumol/l) alone or in combination for 48 h. Curcumin also enhanced the anticancer activity of 5-FU without increasing toxicity in nude mice bearing MKN45 tumor xenografts in vivo.	Curcumin	261-269	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
29151957-11	2017	Furthermore, the protein expressions of COX-2 and NF-kappaB in MKN45 cells were decreased by 44.79% and 37.67%, 47.17% and 48.21%, 60.21% and 62.44%, respectively, after treatment of curcumin (25 mumol/l) and 5-FU (50 mumol/l) alone or in combination for 48 h. Curcumin also enhanced the anticancer activity of 5-FU without increasing toxicity in nude mice bearing MKN45 tumor xenografts in vivo.	Curcumin	261-269	nuclear factor kappa B subunit 1	Homo sapiens	50-59
28736282-8	2017	Curcumin inhibited the proliferation of IMQ-induced differentiated HaCaT cells (Psoriatic-like cells) by down-regulation of pro-inflammatory cytokines, interleukin-17, tumor necrosis factor-alpha, interferon-gamma, and interleukin-6.	Curcumin	0-8	interferon gamma	Homo sapiens	197-213
28736282-8	2017	Curcumin inhibited the proliferation of IMQ-induced differentiated HaCaT cells (Psoriatic-like cells) by down-regulation of pro-inflammatory cytokines, interleukin-17, tumor necrosis factor-alpha, interferon-gamma, and interleukin-6.	Curcumin	0-8	interleukin 6	Homo sapiens	219-232
28736282-9	2017	Apart from this, curcumin significantly enhanced the skin-barrier function by up-regulation of involucrin (iNV) and filaggrin (FLG), the regulators of epidermal skin barrier.	Curcumin	17-25	involucrin	Homo sapiens	95-105
28736282-9	2017	Apart from this, curcumin significantly enhanced the skin-barrier function by up-regulation of involucrin (iNV) and filaggrin (FLG), the regulators of epidermal skin barrier.	Curcumin	17-25	involucrin	Homo sapiens	107-110
28981106-9	2017	Inhibition of NFkappaB with BAY11-7082 or inhibition of histone acetyltransferase with curcumin prevented the NLRP3 inflammasome activation, VSMC phenotype switching and proliferation in VSMCs from SHR.	Curcumin	87-95	NLR family, pyrin domain containing 3	Rattus norvegicus	110-115
28684236-0	2017	Development of insulin resistance through sprouting of inflammatory markers during hypoxia in 3T3-L1 adipocytes and amelioration with curcumin.	Curcumin	134-142	insulin	Homo sapiens	15-22
28684236-9	2017	Curcumin protected adipocytes from hypoxia induced inflammation and insulin resistance via reducing inflammatory adipokine, nuclear factor-kappaB (NF-kappaB)/c-jun N-terminal kinase (JNK) and serine phosphorylation of IRS-1 receptors and improving adiponectin secretion.	Curcumin	0-8	insulin	Homo sapiens	68-75
28684236-9	2017	Curcumin protected adipocytes from hypoxia induced inflammation and insulin resistance via reducing inflammatory adipokine, nuclear factor-kappaB (NF-kappaB)/c-jun N-terminal kinase (JNK) and serine phosphorylation of IRS-1 receptors and improving adiponectin secretion.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	147-157
28684236-9	2017	Curcumin protected adipocytes from hypoxia induced inflammation and insulin resistance via reducing inflammatory adipokine, nuclear factor-kappaB (NF-kappaB)/c-jun N-terminal kinase (JNK) and serine phosphorylation of IRS-1 receptors and improving adiponectin secretion.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	183-186
28684236-9	2017	Curcumin protected adipocytes from hypoxia induced inflammation and insulin resistance via reducing inflammatory adipokine, nuclear factor-kappaB (NF-kappaB)/c-jun N-terminal kinase (JNK) and serine phosphorylation of IRS-1 receptors and improving adiponectin secretion.	Curcumin	0-8	adiponectin, C1Q and collagen domain containing	Homo sapiens	248-259
28847726-2	2017	We demonstrated that curcumin (40 muM) reduced the mitochondrial coupling efficiency (percentage of oxygen consumption coupled to ATP synthesis) of intact skeletal muscle cells.	Curcumin	21-29	latexin	Homo sapiens	34-37
28847726-8	2017	Pretreatment with ursolic acid (0.12 muM) increased the mitochondrial coupling efficiency of intact cells by 4.1 +- 1.1% relative to vehicle (p &lt; 0.008) and attenuated the effect of curcumin when the two compounds were used in combination.	Curcumin	185-193	latexin	Homo sapiens	37-40
28967875-0	2017	Combination curcumin and (-)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway.	Curcumin	12-20	signal transducer and activator of transcription 3	Mus musculus	131-136
28836404-4	2017	This study aimed to evaluate the therapeutic effects of curcumin on IL-6 and CRP levels as well as insulin resistance (IR) index on liver function in PCOS rats.	Curcumin	56-64	interleukin 6	Rattus norvegicus	68-72
28967875-9	2017	Here, we found that curcumin combination with EGCG attenuated the tumor CM-induced transition of NECs toward TECs by inhibiting JAK/STAT3 signaling pathway.	Curcumin	20-28	signal transducer and activator of transcription 3	Mus musculus	132-137
28810535-0	2017	Curcumin enhances the radiosensitivity of renal cancer cells by suppressing NF-kappaB signaling pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	76-85
28810535-8	2017	In addition, curcumin enhanced radiosensitivity was through markedly inhibiting IR-induced NF-kappaB signaling by modulating the related protein expressions including NF-kappaBP65, I-kappaB, VEGF, COX2, and Bcl-2 in ACHN cells, which was further strengthened by NF-kappaB inhibitor PDTC treatment.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	91-100
28810535-8	2017	In addition, curcumin enhanced radiosensitivity was through markedly inhibiting IR-induced NF-kappaB signaling by modulating the related protein expressions including NF-kappaBP65, I-kappaB, VEGF, COX2, and Bcl-2 in ACHN cells, which was further strengthened by NF-kappaB inhibitor PDTC treatment.	Curcumin	13-21	vascular endothelial growth factor A	Homo sapiens	191-195
28810535-8	2017	In addition, curcumin enhanced radiosensitivity was through markedly inhibiting IR-induced NF-kappaB signaling by modulating the related protein expressions including NF-kappaBP65, I-kappaB, VEGF, COX2, and Bcl-2 in ACHN cells, which was further strengthened by NF-kappaB inhibitor PDTC treatment.	Curcumin	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-201
28810535-8	2017	In addition, curcumin enhanced radiosensitivity was through markedly inhibiting IR-induced NF-kappaB signaling by modulating the related protein expressions including NF-kappaBP65, I-kappaB, VEGF, COX2, and Bcl-2 in ACHN cells, which was further strengthened by NF-kappaB inhibitor PDTC treatment.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	207-212
28810535-8	2017	In addition, curcumin enhanced radiosensitivity was through markedly inhibiting IR-induced NF-kappaB signaling by modulating the related protein expressions including NF-kappaBP65, I-kappaB, VEGF, COX2, and Bcl-2 in ACHN cells, which was further strengthened by NF-kappaB inhibitor PDTC treatment.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	167-176
28810535-9	2017	Thus, curcumin may confer radiosensitivity on RCC via inhibition of NF-kappaB activation and its downstream regulars, suggesting the potential application of curcumin as an adjuvant in radiotherapy of RCC.	Curcumin	6-14	nuclear factor kappa B subunit 1	Homo sapiens	68-77
28810535-9	2017	Thus, curcumin may confer radiosensitivity on RCC via inhibition of NF-kappaB activation and its downstream regulars, suggesting the potential application of curcumin as an adjuvant in radiotherapy of RCC.	Curcumin	158-166	nuclear factor kappa B subunit 1	Homo sapiens	68-77
28504250-8	2017	Knockdown of caveolin-1 or activation of Notch1 signaling with Jagged1 (2 mug/mL) diminished these effects of curcumin in VSMCs.	Curcumin	110-118	jagged 1	Mus musculus	63-70
29048549-0	2017	Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression.	Curcumin	0-8	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	87-91
29048549-9	2017	Using gemcitabine-resistant PDAC cell lines, we found that curcumin sensitized chemoresistant cancer cells by inhibiting the expression of the PRC2 subunit EZH2 and its related lncRNA PVT1.	Curcumin	59-67	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	156-160
28836404-4	2017	This study aimed to evaluate the therapeutic effects of curcumin on IL-6 and CRP levels as well as insulin resistance (IR) index on liver function in PCOS rats.	Curcumin	56-64	C-reactive protein	Rattus norvegicus	77-80
28836404-10	2017	RESULTS: Histological and serological analyses showed a reduction in number of necrotic cells, IR index, as well as IL-6 and CRP levels in PCOS rats that were treated with various concentrations of curcumin.	Curcumin	198-206	interleukin 6	Rattus norvegicus	116-120
28836404-10	2017	RESULTS: Histological and serological analyses showed a reduction in number of necrotic cells, IR index, as well as IL-6 and CRP levels in PCOS rats that were treated with various concentrations of curcumin.	Curcumin	198-206	C-reactive protein	Rattus norvegicus	125-128
28992163-0	2017	Pak1 mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression.	Curcumin	52-60	MLX interacting protein-like	Mus musculus	72-78
29028430-12	2017	In LPS- and ATP-induced THP-1 macrophage cells, curcumin significantly suppressed the expression of interleukin 1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) at both RNA and protein levels.	Curcumin	48-56	interleukin 1 beta	Homo sapiens	100-118
29028430-12	2017	In LPS- and ATP-induced THP-1 macrophage cells, curcumin significantly suppressed the expression of interleukin 1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) at both RNA and protein levels.	Curcumin	48-56	interleukin 1 beta	Homo sapiens	120-128
29028430-12	2017	In LPS- and ATP-induced THP-1 macrophage cells, curcumin significantly suppressed the expression of interleukin 1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) at both RNA and protein levels.	Curcumin	48-56	tumor necrosis factor	Homo sapiens	134-161
29028430-12	2017	In LPS- and ATP-induced THP-1 macrophage cells, curcumin significantly suppressed the expression of interleukin 1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) at both RNA and protein levels.	Curcumin	48-56	tumor necrosis factor	Homo sapiens	163-172
28370178-3	2017	In vitro, it has been shown that curcumin can decrease hepcidin synthesis by decreasing STAT3 activity.	Curcumin	33-41	signal transducer and activator of transcription 3	Homo sapiens	88-93
28849163-0	2017	Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKbeta/NF-kappaB/COX-2 signaling pathway.	Curcumin	46-54	nuclear factor kappa B subunit 1	Homo sapiens	77-86
28849163-0	2017	Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKbeta/NF-kappaB/COX-2 signaling pathway.	Curcumin	46-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
28849163-6	2017	In addition, combined treatment with curcumin and melatonin induced cell apoptosis in bladder cancer through enhancing the release of cytochrome c from the mitochondrial intermembrane space into the cytosol.	Curcumin	37-45	cytochrome c, somatic	Homo sapiens	134-146
28850308-10	2017	The results indicate that this novel curcumin in a turmeric matrix acts as an analgesic and anti-inflammatory agent for the management of RA at a dose as low as 250 mg twice daily as evidenced by significant improvement in the ESR, CRP, VAS, RF, DAS28, and ACR responses compared to placebo.	Curcumin	37-45	C-reactive protein	Homo sapiens	232-235
28992163-2	2017	As recent studies revealed potential metabolic beneficial effects of ChREBP, we asked whether its expression can also be regulated by the dietary polyphenol curcumin.	Curcumin	157-165	MLX interacting protein-like	Mus musculus	69-75
28992163-3	2017	We also aimed to determine mechanisms underlying ChREBP stimulation by insulin and curcumin.	Curcumin	83-91	MLX interacting protein-like	Mus musculus	49-55
28992163-6	2017	We found that both insulin and curcumin-stimulated ChREBP expression in Akt-independent but MEK/ERK-dependent manner, involving the inactivation of the transcriptional repressor Oct-1.	Curcumin	31-39	MLX interacting protein-like	Mus musculus	51-57
28992163-6	2017	We found that both insulin and curcumin-stimulated ChREBP expression in Akt-independent but MEK/ERK-dependent manner, involving the inactivation of the transcriptional repressor Oct-1.	Curcumin	31-39	thymoma viral proto-oncogene 1	Mus musculus	72-75
28992163-6	2017	We found that both insulin and curcumin-stimulated ChREBP expression in Akt-independent but MEK/ERK-dependent manner, involving the inactivation of the transcriptional repressor Oct-1.	Curcumin	31-39	mitogen-activated protein kinase 1	Mus musculus	96-99
28992163-8	2017	Pak1 inhibition or its genetic deletion attenuated the stimulatory effect of insulin or curcumin on ChREBP expression.	Curcumin	88-96	MLX interacting protein-like	Mus musculus	100-106
28992163-9	2017	Our study hence suggests the existence of a novel signaling cascade Pak1/MEK/ERK/Oct-1 for both insulin and curcumin in exerting their glucose-lowering effect via promoting hepatic ChREBP production, supports the recognition of beneficial functions of ChREBP, and brings us a new overview on dietary polyphenols.	Curcumin	108-116	mitogen-activated protein kinase 1	Mus musculus	77-80
28992163-9	2017	Our study hence suggests the existence of a novel signaling cascade Pak1/MEK/ERK/Oct-1 for both insulin and curcumin in exerting their glucose-lowering effect via promoting hepatic ChREBP production, supports the recognition of beneficial functions of ChREBP, and brings us a new overview on dietary polyphenols.	Curcumin	108-116	MLX interacting protein-like	Mus musculus	181-187
28992163-9	2017	Our study hence suggests the existence of a novel signaling cascade Pak1/MEK/ERK/Oct-1 for both insulin and curcumin in exerting their glucose-lowering effect via promoting hepatic ChREBP production, supports the recognition of beneficial functions of ChREBP, and brings us a new overview on dietary polyphenols.	Curcumin	108-116	MLX interacting protein-like	Mus musculus	252-258
28676971-6	2017	Elevated ROS also increased the expression of COX-2 and APE1 enzymes and pretreatment of Curcumin and Quercetin decreased COX-2 expression and increased APE1 expression in the oxidatively stressed U-87 MG cells.	Curcumin	89-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127
28849024-0	2017	Inhibitory effect of curcumin in human endometriosis endometrial cells via downregulation of vascular endothelial growth factor.	Curcumin	21-29	vascular endothelial growth factor A	Homo sapiens	93-127
28731157-8	2017	Furthermore, NF-kappaB p65 expression in the nucleus and the DNA binding activity of NF-kappaB in rat LPS-exposed VSMCs was decreased by curcumin.	Curcumin	137-145	synaptotagmin 1	Rattus norvegicus	23-26
28849024-13	2017	Treatment with curcumin additionally decreased expression of VEGF.	Curcumin	15-23	vascular endothelial growth factor A	Homo sapiens	61-65
28849024-14	2017	The data provide evidence that curcumin reduces cell survival in human endometriotic stromal cells, and this may be mediated via downregulation of the VEGF signaling pathway.	Curcumin	31-39	vascular endothelial growth factor A	Homo sapiens	151-155
29085504-0	2017	Curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	94-99
29085504-7	2017	The results of the present study suggest that curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a.	Curcumin	46-54	BCL2 apoptosis regulator	Homo sapiens	140-145
29201665-2	2017	This study aimed at investigating the therapeutic effects of curcumin on IL-6, CRP and TNF-alpha and symptoms of polycystic ovary syndrome.	Curcumin	61-69	interleukin 6	Rattus norvegicus	73-77
29201665-2	2017	This study aimed at investigating the therapeutic effects of curcumin on IL-6, CRP and TNF-alpha and symptoms of polycystic ovary syndrome.	Curcumin	61-69	C-reactive protein	Rattus norvegicus	79-82
29201665-2	2017	This study aimed at investigating the therapeutic effects of curcumin on IL-6, CRP and TNF-alpha and symptoms of polycystic ovary syndrome.	Curcumin	61-69	tumor necrosis factor	Rattus norvegicus	87-96
29201665-9	2017	Results: Histological studies showed a significant reduction in thickness of theca layer and increase in the number of corpus luteum (CL) diameter in the curcumin-treated group compared with the PCOS group; also inflammatory markers such as IL-6 and CRP significantly decreased in groups treated with curcumin compared with PCOS groups.	Curcumin	154-162	interleukin 6	Rattus norvegicus	241-245
29201665-9	2017	Results: Histological studies showed a significant reduction in thickness of theca layer and increase in the number of corpus luteum (CL) diameter in the curcumin-treated group compared with the PCOS group; also inflammatory markers such as IL-6 and CRP significantly decreased in groups treated with curcumin compared with PCOS groups.	Curcumin	154-162	C-reactive protein	Rattus norvegicus	250-253
29201665-12	2017	Conclusion: This study showed that the anti-inflammatory and antioxidant effects of curcumin on PCOS may be due to its inhibitory effect on expression and levels of TNF-alpha, serum IL-6 and CRP.	Curcumin	84-92	tumor necrosis factor	Rattus norvegicus	165-174
29201665-12	2017	Conclusion: This study showed that the anti-inflammatory and antioxidant effects of curcumin on PCOS may be due to its inhibitory effect on expression and levels of TNF-alpha, serum IL-6 and CRP.	Curcumin	84-92	interleukin 6	Rattus norvegicus	182-186
29201665-12	2017	Conclusion: This study showed that the anti-inflammatory and antioxidant effects of curcumin on PCOS may be due to its inhibitory effect on expression and levels of TNF-alpha, serum IL-6 and CRP.	Curcumin	84-92	C-reactive protein	Rattus norvegicus	191-194
29085504-7	2017	The results of the present study suggest that curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a.	Curcumin	46-54	AKT serine/threonine kinase 1	Homo sapiens	155-158
29085504-0	2017	Curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	109-112
29085504-2	2017	The aim of the present study was to investigate whether curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer through Bcl-2 and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), and by upregulating microRNA-15a (miR-15a).	Curcumin	56-64	BCL2 apoptosis regulator	Homo sapiens	144-149
29085504-2	2017	The aim of the present study was to investigate whether curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer through Bcl-2 and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), and by upregulating microRNA-15a (miR-15a).	Curcumin	56-64	AKT serine/threonine kinase 1	Homo sapiens	205-208
29085504-3	2017	It was demonstrated that curcumin inhibits cell proliferation, and promotes apoptosis and increased caspase-3 activity of human laryngeal cancer cells.	Curcumin	25-33	caspase 3	Homo sapiens	100-109
29085504-4	2017	Furthermore, curcumin decreased Bcl-2 and PI3K protein expression, and decreased the phospho (p)-Akt protein expression of human laryngeal cancer cells.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	32-37
29085504-4	2017	Furthermore, curcumin decreased Bcl-2 and PI3K protein expression, and decreased the phospho (p)-Akt protein expression of human laryngeal cancer cells.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	97-100
28941865-10	2017	RESULTS: The experiment showed that curcumin markedly inhibited SCI-induced production of inflammatory mediators, including TNF-alpha, IL-1beta, IL-6 (ELISA assay) and nitrite oxide (Griess method) in a concentration-dependent manner.	Curcumin	36-44	tumor necrosis factor	Mus musculus	124-133
28941865-10	2017	RESULTS: The experiment showed that curcumin markedly inhibited SCI-induced production of inflammatory mediators, including TNF-alpha, IL-1beta, IL-6 (ELISA assay) and nitrite oxide (Griess method) in a concentration-dependent manner.	Curcumin	36-44	interleukin 1 beta	Mus musculus	135-143
28941865-10	2017	RESULTS: The experiment showed that curcumin markedly inhibited SCI-induced production of inflammatory mediators, including TNF-alpha, IL-1beta, IL-6 (ELISA assay) and nitrite oxide (Griess method) in a concentration-dependent manner.	Curcumin	36-44	interleukin 6	Mus musculus	145-149
28870897-6	2017	Detailed analyses revealed that the mTORC1 and p53 signaling pathways are main targets of curcumin.	Curcumin	90-98	tumor protein p53	Homo sapiens	47-50
28806703-0	2017	NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin.	Curcumin	153-161	CASP8 and FADD like apoptosis regulator	Homo sapiens	81-87
28806703-6	2017	Among apoptosis-related proteins, thioridazine plus curcumin induced down-regulation of c-FLIP and Mcl-1 expression at the post-translational levels in a proteasome-dependent manner.	Curcumin	52-60	CASP8 and FADD like apoptosis regulator	Homo sapiens	88-94
28806703-9	2017	Furthermore, ectopic expression of c-FLIP and Mcl-1 inhibited apoptosis in thioridazine and curcumin-treated cells.	Curcumin	92-100	CASP8 and FADD like apoptosis regulator	Homo sapiens	35-41
29254150-0	2017	Novel allylated monocarbonyl analogs of curcumin induce mitotic arrest and apoptosis by reactive oxygen species-mediated endoplasmic reticulum stress and inhibition of STAT3.	Curcumin	40-48	signal transducer and activator of transcription 3	Mus musculus	168-173
28719149-7	2017	Curcumin can afford to attenuate lipid peroxidation, glutathione depletion, alterations in antioxidant enzyme, and so forth through scavenging and chelating activities or Nrf2/Keap1/ARE pathway induction.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	171-175
28719149-7	2017	Curcumin can afford to attenuate lipid peroxidation, glutathione depletion, alterations in antioxidant enzyme, and so forth through scavenging and chelating activities or Nrf2/Keap1/ARE pathway induction.	Curcumin	0-8	kelch like ECH associated protein 1	Homo sapiens	176-181
28848967-14	2017	The expression of DEC1, HIF-1alpha, STAT3 and VEGF in tumor tissues was down-regulated after curcumin treatment.	Curcumin	93-101	basic helix-loop-helix family, member e40	Mus musculus	18-22
28848967-14	2017	The expression of DEC1, HIF-1alpha, STAT3 and VEGF in tumor tissues was down-regulated after curcumin treatment.	Curcumin	93-101	signal transducer and activator of transcription 3	Mus musculus	36-41
28848967-15	2017	Our results indicate that curcumin inhibits the proliferation of gastric carcinoma by inducing the apoptosis of tumor cells, activating immune cells to secrete a large amount of cytokines, and down-regulating the DEC1, HIF-1alpha, VEGF and STAT3 signal transduction pathways.	Curcumin	26-34	basic helix-loop-helix family, member e40	Mus musculus	213-217
28848967-15	2017	Our results indicate that curcumin inhibits the proliferation of gastric carcinoma by inducing the apoptosis of tumor cells, activating immune cells to secrete a large amount of cytokines, and down-regulating the DEC1, HIF-1alpha, VEGF and STAT3 signal transduction pathways.	Curcumin	26-34	signal transducer and activator of transcription 3	Mus musculus	240-245
28887914-0	2017	Curcumin attenuates the scurfy-induced immune disorder, a model of IPEX syndrome, with inhibiting Th1/Th2/Th17 responses in mice.	Curcumin	0-8	negative elongation factor complex member C/D, Th1l	Mus musculus	98-101
28887914-9	2017	A curcumin diet decreased all of the Th1/Th2/Th17 cell populations and attenuated diverse symptoms such as splenomegaly in scurfy mice.	Curcumin	2-10	negative elongation factor complex member C/D, Th1l	Mus musculus	37-40
28887914-10	2017	In vitro experiments showed that curcumin treatment directly decreased the Th1/Th2/Th17 cytokine production of IFN-gamma, IL-4, and IL-17A in CD4+ T cells.	Curcumin	33-41	negative elongation factor complex member C/D, Th1l	Mus musculus	75-78
28887914-10	2017	In vitro experiments showed that curcumin treatment directly decreased the Th1/Th2/Th17 cytokine production of IFN-gamma, IL-4, and IL-17A in CD4+ T cells.	Curcumin	33-41	interferon gamma	Mus musculus	111-120
28887914-11	2017	CONCLUSIONS: Curcumin diet attenuated the scurfy-induced immune disorder, a model of IPEX syndrome, by inhibiting Th1/Th2/Th17 responses in mice.	Curcumin	13-21	negative elongation factor complex member C/D, Th1l	Mus musculus	114-117
27837179-8	2017	Pretreatment with curcumin obviously prevented HgCl2-induced liver oxidative stress, which may be due to its free radical scavenging or Nrf2-ARE pathway-inducing properties.	Curcumin	18-26	NFE2 like bZIP transcription factor 2	Rattus norvegicus	136-140
28658644-7	2017	As a result, the binding free energy of the EGCG to the Abeta peptides is slightly larger than that of the curcumin.	Curcumin	107-115	amyloid beta precursor protein	Homo sapiens	56-61
28646616-8	2017	Moreover, the NF-kappaB has been activated in human macrophages after IAV infection, while administration of curcumin inhibited NF-kappaB signaling pathway via promoting the expression of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha), and inhibiting the translocation of p65 from cytoplasm to nucleus.	Curcumin	109-117	NFKB inhibitor alpha	Homo sapiens	188-271
28646616-8	2017	Moreover, the NF-kappaB has been activated in human macrophages after IAV infection, while administration of curcumin inhibited NF-kappaB signaling pathway via promoting the expression of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha), and inhibiting the translocation of p65 from cytoplasm to nucleus.	Curcumin	109-117	NFKB inhibitor alpha	Homo sapiens	273-285
28713935-9	2017	The results suggested that curcumin reduced PM2.5 (300 microg/ml)-induced cell apoptosis and intracellular caspase 3 activity in HMEC-1.	Curcumin	27-35	caspase 3	Homo sapiens	107-116
28575972-4	2017	After irradiation, the obtained curcumin loaded micelle showed a better transfection, and the p53 protein expression in Hela cells was higher.	Curcumin	32-40	tumor protein p53	Homo sapiens	94-97
28575972-5	2017	The apoptosis assay showed that the complex could induce a more significant apoptosis to Hela cells than that of curcumin or p53 used alone, and the curcumin loaded micelle inducing apoptosis was best after irradiation.	Curcumin	149-157	tumor protein p53	Homo sapiens	125-128
28713935-10	2017	ELISA analysis demonstrated that curcumin reduced PM2.5-induced oxLDL, TNF-alpha and IL-8 levels.	Curcumin	33-41	tumor necrosis factor	Homo sapiens	71-80
28713935-10	2017	ELISA analysis demonstrated that curcumin reduced PM2.5-induced oxLDL, TNF-alpha and IL-8 levels.	Curcumin	33-41	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
28713935-11	2017	Curcumin induced NF-kappaB, cell adhesion molecule 1 and vascular cell adhesion protein 1 expression.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	17-26
28713935-11	2017	Curcumin induced NF-kappaB, cell adhesion molecule 1 and vascular cell adhesion protein 1 expression.	Curcumin	0-8	cell adhesion molecule 1	Homo sapiens	28-52
28713935-11	2017	Curcumin induced NF-kappaB, cell adhesion molecule 1 and vascular cell adhesion protein 1 expression.	Curcumin	0-8	vascular cell adhesion molecule 1	Homo sapiens	57-89
28894373-0	2017	Curcumin inhibits apoptosis by modulating Bax/Bcl-2 expression and alleviates oxidative stress in testes of streptozotocin-induced diabetic rats.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	46-51
28238790-5	2017	In this work, liposomes (LIP) were functionalized as previously shown in order to promote high-affinity Abeta binding, i.e., either with, phosphatidic acid (PA), or a modified Apolipoprotein E-derived peptide (mApo), or with a curcumin derivative (TREG); Abeta42 levels were determined by ELISA in CSF and plasma samples.	Curcumin	227-235	amyloid beta precursor protein	Homo sapiens	104-109
28927092-7	2017	The rate of apoptosis, caspase-3/caspase-8 activity and the expression of Bax were significantly increased, whereas Bcl-2 expression was significantly reduced following treatment with curcumin and/or FP, compared with the untreated control group.	Curcumin	184-192	caspase 3	Homo sapiens	23-32
28927092-7	2017	The rate of apoptosis, caspase-3/caspase-8 activity and the expression of Bax were significantly increased, whereas Bcl-2 expression was significantly reduced following treatment with curcumin and/or FP, compared with the untreated control group.	Curcumin	184-192	BCL2 associated X, apoptosis regulator	Homo sapiens	74-77
28927092-7	2017	The rate of apoptosis, caspase-3/caspase-8 activity and the expression of Bax were significantly increased, whereas Bcl-2 expression was significantly reduced following treatment with curcumin and/or FP, compared with the untreated control group.	Curcumin	184-192	BCL2 apoptosis regulator	Homo sapiens	116-121
28927092-9	2017	Therefore, curcumin may enhance the anticancer effects of FP chemotherapy in MGC-803 cells through the promotion of apoptosis via the caspase-3/caspase-8, Bcl-2 and Bax signaling pathways.	Curcumin	11-19	caspase 3	Homo sapiens	134-143
28927092-9	2017	Therefore, curcumin may enhance the anticancer effects of FP chemotherapy in MGC-803 cells through the promotion of apoptosis via the caspase-3/caspase-8, Bcl-2 and Bax signaling pathways.	Curcumin	11-19	BCL2 apoptosis regulator	Homo sapiens	155-160
28927092-9	2017	Therefore, curcumin may enhance the anticancer effects of FP chemotherapy in MGC-803 cells through the promotion of apoptosis via the caspase-3/caspase-8, Bcl-2 and Bax signaling pathways.	Curcumin	11-19	BCL2 associated X, apoptosis regulator	Homo sapiens	165-168
28860665-9	2017	The results showed that curcumin exerts renoprotective effects by inhibiting oxidative stress in rhabdomyolysis-induced AKI through regulation of the AMPK and Nrf2/HO-1 signaling pathways, and also ameliorated RM-associated renal injury and cell apoptosis by activating the PI3K/Akt pathway.	Curcumin	24-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	159-163
28860665-9	2017	The results showed that curcumin exerts renoprotective effects by inhibiting oxidative stress in rhabdomyolysis-induced AKI through regulation of the AMPK and Nrf2/HO-1 signaling pathways, and also ameliorated RM-associated renal injury and cell apoptosis by activating the PI3K/Akt pathway.	Curcumin	24-32	AKT serine/threonine kinase 1	Rattus norvegicus	279-282
29084689-4	2017	Curcumin significantly reduced cell viability, induced apoptosis, activated caspase-3 activity and stimulated concentration-dependent release of ROS.	Curcumin	0-8	caspase 3	Homo sapiens	76-85
29084689-5	2017	Inhibition of ROS generation by scavengers suppressed apoptosis and Bcl-2 expression induced by curcumin, indicating the critical roles of ROS in the apoptotic process.	Curcumin	96-104	BCL2 apoptosis regulator	Homo sapiens	68-73
28855623-5	2017	At equivalent concentrations, a single oral dose of PLGA-curcumin was more effective in inhibiting serum IFNgamma levels and enhancing IL-10 levels than native curcumin.	Curcumin	57-65	interferon gamma	Homo sapiens	105-113
28894373-7	2017	Molecular analysis demonstrated that curcumin treatment significantly and simultaneously decreased Bax and increased Bcl-2 expressions, therefore elevating the ratio of Bcl-2/Bax.	Curcumin	37-45	BCL2, apoptosis regulator	Rattus norvegicus	117-122
28669709-0	2017	A mechanistic insight into curcumin modulation of the IL-1beta secretion and NLRP3 S-glutathionylation induced by needle-like cationic cellulose nanocrystals in myeloid cells.	Curcumin	27-35	interleukin 1 beta	Mus musculus	54-62
28669709-2	2017	In this study we demonstrated that curcumin, a naturally occurring polyphenolic compound isolated from Curcuma longa (Zingiberaceae), was able to suppress, at least in part, this immunological response, as observed by diminished IL-1beta secretion in CNC-AEMA2-stimulated macrophages primed with LPS.	Curcumin	35-43	interleukin 1 beta	Mus musculus	229-237
28669709-5	2017	We hypothesize that curcumin may also affect S-glutathionylation of key proteins involved in the NLRP3 inflammasome/IL-1beta pathway, and therefore impact their protein-protein interactions.	Curcumin	20-28	interleukin 1 beta	Mus musculus	116-124
28894373-7	2017	Molecular analysis demonstrated that curcumin treatment significantly and simultaneously decreased Bax and increased Bcl-2 expressions, therefore elevating the ratio of Bcl-2/Bax.	Curcumin	37-45	BCL2, apoptosis regulator	Rattus norvegicus	169-174
28894373-10	2017	The capability of curcumin in inhibiting oxidative stress and modulating the Bax/Bcl-2-mediated cell death pathway reveals its potential as a therapeutic agent against diabetes.	Curcumin	18-26	BCL2, apoptosis regulator	Rattus norvegicus	81-86
28669709-8	2017	Taking together, our results suggest that, at least in part, the anti-inflammatory activity of curcumin is associated with changes in S-glutathionylation of key NLRP3 inflammasome components, and perhaps resulting in sustained complex assembly and suppression of IL-1beta secretion.	Curcumin	95-103	interleukin 1 beta	Mus musculus	263-271
28595985-9	2017	These results suggest that curcumin might be an inhibitor of BBP-induced weight gain and inflammation via stimulation of adipocyte differentiation and TNFalpha generation.	Curcumin	27-35	tumor necrosis factor	Mus musculus	151-159
28884090-9	2017	Curcumin monotherapy slightly suppressed bacterial growth, alleviated bone infection and reduced TNF-alpha and IL-6.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	97-106
28884090-9	2017	Curcumin monotherapy slightly suppressed bacterial growth, alleviated bone infection and reduced TNF-alpha and IL-6.	Curcumin	0-8	interleukin 6	Rattus norvegicus	111-115
28861154-7	2017	STAT3 pathway was involved in curcumin-induced tumor inhibition, in which phosphorylation of STAT3 and JAK in ectopic xenograft were both declined after curcumin treatment, and the STAT3-regulated promoter activation of VEGF, Bcl-xL, Cyclin D1 was also significantly reduced after treatment.	Curcumin	30-38	signal transducer and activator of transcription 3	Homo sapiens	93-98
28861154-7	2017	STAT3 pathway was involved in curcumin-induced tumor inhibition, in which phosphorylation of STAT3 and JAK in ectopic xenograft were both declined after curcumin treatment, and the STAT3-regulated promoter activation of VEGF, Bcl-xL, Cyclin D1 was also significantly reduced after treatment.	Curcumin	30-38	vascular endothelial growth factor A	Homo sapiens	220-224
28861154-7	2017	STAT3 pathway was involved in curcumin-induced tumor inhibition, in which phosphorylation of STAT3 and JAK in ectopic xenograft were both declined after curcumin treatment, and the STAT3-regulated promoter activation of VEGF, Bcl-xL, Cyclin D1 was also significantly reduced after treatment.	Curcumin	30-38	BCL2 like 1	Homo sapiens	226-232
28861154-7	2017	STAT3 pathway was involved in curcumin-induced tumor inhibition, in which phosphorylation of STAT3 and JAK in ectopic xenograft were both declined after curcumin treatment, and the STAT3-regulated promoter activation of VEGF, Bcl-xL, Cyclin D1 was also significantly reduced after treatment.	Curcumin	153-161	signal transducer and activator of transcription 3	Homo sapiens	0-5
28861154-7	2017	STAT3 pathway was involved in curcumin-induced tumor inhibition, in which phosphorylation of STAT3 and JAK in ectopic xenograft were both declined after curcumin treatment, and the STAT3-regulated promoter activation of VEGF, Bcl-xL, Cyclin D1 was also significantly reduced after treatment.	Curcumin	153-161	signal transducer and activator of transcription 3	Homo sapiens	93-98
28861154-7	2017	STAT3 pathway was involved in curcumin-induced tumor inhibition, in which phosphorylation of STAT3 and JAK in ectopic xenograft were both declined after curcumin treatment, and the STAT3-regulated promoter activation of VEGF, Bcl-xL, Cyclin D1 was also significantly reduced after treatment.	Curcumin	153-161	signal transducer and activator of transcription 3	Homo sapiens	93-98
28861154-7	2017	STAT3 pathway was involved in curcumin-induced tumor inhibition, in which phosphorylation of STAT3 and JAK in ectopic xenograft were both declined after curcumin treatment, and the STAT3-regulated promoter activation of VEGF, Bcl-xL, Cyclin D1 was also significantly reduced after treatment.	Curcumin	153-161	vascular endothelial growth factor A	Homo sapiens	220-224
28861154-7	2017	STAT3 pathway was involved in curcumin-induced tumor inhibition, in which phosphorylation of STAT3 and JAK in ectopic xenograft were both declined after curcumin treatment, and the STAT3-regulated promoter activation of VEGF, Bcl-xL, Cyclin D1 was also significantly reduced after treatment.	Curcumin	153-161	BCL2 like 1	Homo sapiens	226-232
28861154-9	2017	All data showed that curcumin could be a potential drug targeting STAT3 to treat NSCLC.	Curcumin	21-29	signal transducer and activator of transcription 3	Homo sapiens	66-71
28884090-10	2017	Erythromycin and curcumin combined treatment markedly suppressed bacterial growth, substantially alleviated bone infection and reduced TNF-alpha and IL-6.	Curcumin	17-25	tumor necrosis factor	Rattus norvegicus	135-144
28884090-10	2017	Erythromycin and curcumin combined treatment markedly suppressed bacterial growth, substantially alleviated bone infection and reduced TNF-alpha and IL-6.	Curcumin	17-25	interleukin 6	Rattus norvegicus	149-153
28861154-0	2017	Curcumin inhibits human non-small cell lung cancer xenografts by targeting STAT3 pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	75-80
28861154-7	2017	STAT3 pathway was involved in curcumin-induced tumor inhibition, in which phosphorylation of STAT3 and JAK in ectopic xenograft were both declined after curcumin treatment, and the STAT3-regulated promoter activation of VEGF, Bcl-xL, Cyclin D1 was also significantly reduced after treatment.	Curcumin	30-38	signal transducer and activator of transcription 3	Homo sapiens	0-5
28861154-7	2017	STAT3 pathway was involved in curcumin-induced tumor inhibition, in which phosphorylation of STAT3 and JAK in ectopic xenograft were both declined after curcumin treatment, and the STAT3-regulated promoter activation of VEGF, Bcl-xL, Cyclin D1 was also significantly reduced after treatment.	Curcumin	30-38	signal transducer and activator of transcription 3	Homo sapiens	93-98
28838334-11	2017	After treatment the contents of TNF-alpha and IL-8 decreased significantly in the group of curcumin plus soy oligosaccharide compared with the model group with statistical significance (P &amp;lt;0.01) while the contents were close to those in the SASP group.	Curcumin	91-99	tumor necrosis factor	Rattus norvegicus	32-41
29245915-10	2017	Multiplex analyses of plasma taken after drug exposure at animal nadir indicated that the levels of M-CSF, CXCL-9, PDGF and G-CSF were significantly increased by [curcumin + sildenafil] and that expression of CXCL1 and CCL5 were significantly reduced.	Curcumin	163-171	C-X-C motif chemokine ligand 9	Homo sapiens	107-113
29245915-1	2017	The present studies focused on the ability of the phosphodiesterase 5 (PDE5) inhibitor sildenafil to enhance the anti-cancer properties of clinically relevant concentrations of the dietary diarylheptanoid curcumin.	Curcumin	205-213	phosphodiesterase 5A	Homo sapiens	50-69
29245915-1	2017	The present studies focused on the ability of the phosphodiesterase 5 (PDE5) inhibitor sildenafil to enhance the anti-cancer properties of clinically relevant concentrations of the dietary diarylheptanoid curcumin.	Curcumin	205-213	phosphodiesterase 5A	Homo sapiens	71-75
29245915-7	2017	Curcumin and sildenafil exposure reduced the expression of MCL-1, BCL-XL, thioredoxin and superoxide dismutase 2 (SOD2) in an eIF2alpha-dependent fashion.	Curcumin	0-8	BCL2 like 1	Homo sapiens	66-72
28948084-10	2017	SAH-induced MCP-1 and TNF-alpha overexpression were inhibited in curcumin-treated group (p &lt; .05).	Curcumin	65-73	mast cell protease 1-like 1	Rattus norvegicus	12-17
28948084-10	2017	SAH-induced MCP-1 and TNF-alpha overexpression were inhibited in curcumin-treated group (p &lt; .05).	Curcumin	65-73	tumor necrosis factor	Rattus norvegicus	22-31
28948084-11	2017	Importantly, phosphor-p65 was significantly inhibited after curcumin treatment (p &lt; .05).	Curcumin	60-68	synaptotagmin 1	Rattus norvegicus	22-25
28781627-9	2017	The present study indicated that curcumin attenuates hypoxic-ischemic brain injury in neonatal rats through the induction of Nrf2 and HO-1.	Curcumin	33-41	NFE2 like bZIP transcription factor 2	Rattus norvegicus	125-129
28529240-4	2017	Mn-induced mitochondria-related apoptotic characteristics, such as caspase-3 and -9 activation, cytochrome c release, Bax increase, and Bcl-2 decrease, were significantly suppressed by curcumin.	Curcumin	185-193	B cell leukemia/lymphoma 2	Mus musculus	136-141
28529240-8	2017	Furthermore, curcumin was able to induce heme oxygenase (HO)-1 expression.	Curcumin	13-21	heme oxygenase 1	Mus musculus	41-62
28427956-0	2017	Curcumin/poly(2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline) formulation: An improved penetration and biological effect of curcumin in F508del-CFTR cell lines.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	159-163
28427956-0	2017	Curcumin/poly(2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline) formulation: An improved penetration and biological effect of curcumin in F508del-CFTR cell lines.	Curcumin	139-147	CF transmembrane conductance regulator	Homo sapiens	159-163
28810635-8	2017	Furthermore, curcumin markedly decreased serum TNF-alpha and IL-6 levels and downregulated renal protein levels of JAK2/STAT3 pathway components.	Curcumin	13-21	tumor necrosis factor	Rattus norvegicus	47-56
28810635-8	2017	Furthermore, curcumin markedly decreased serum TNF-alpha and IL-6 levels and downregulated renal protein levels of JAK2/STAT3 pathway components.	Curcumin	13-21	interleukin 6	Rattus norvegicus	61-65
28622711-11	2017	In vitro, curcumin could accelerate cell autophagy through regulating autophagy related Erk1/2 and Akt pathway, prevent cell apoptosis and promote expression of PMP22 and S100, and reduced deposition of Fibrin in cultured RSC96 SCs.	Curcumin	10-18	AKT serine/threonine kinase 1	Rattus norvegicus	99-102
28781627-0	2017	Curcumin attenuates hypoxic-ischemic brain injury in neonatal rats through induction of nuclear factor erythroid-2-related factor 2 and heme oxygenase-1.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	88-131
28781627-2	2017	In the present study, whether the attenuating effects of curcumin against hypoxic-ischemic brain injury in neonatal rats are mediated via nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) was investigated.	Curcumin	57-65	NFE2 like bZIP transcription factor 2	Rattus norvegicus	138-181
28349250-0	2017	Curcumin improves treatment outcome of Takayasu arteritis patients by reducing TNF-alpha: a randomized placebo-controlled double-blind clinical trial.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	79-88
28781627-2	2017	In the present study, whether the attenuating effects of curcumin against hypoxic-ischemic brain injury in neonatal rats are mediated via nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) was investigated.	Curcumin	57-65	NFE2 like bZIP transcription factor 2	Rattus norvegicus	183-187
28781627-7	2017	Furthermore, treatment with curcumin significantly attenuated the changes in SOD activity and MDA levels and suppressed the iNOS protein expression induced in neonatal rats by hypoxic-ischemic brain injury.	Curcumin	28-36	nitric oxide synthase 2	Rattus norvegicus	124-128
28781627-8	2017	Treatment with curcumin significantly increased Nrf2 and HO-1 expression in the neonatal rats with hypoxic-ischemic brain injury.	Curcumin	15-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	48-52
28349250-2	2017	The aim of this study is to investigate a natural anti-TNF compound, curcumin, its function, and its potential as treatment against TA.	Curcumin	69-77	tumor necrosis factor	Homo sapiens	55-58
28349250-8	2017	The treatment outcome was greatly improved by curcumin administration probably due to its anti-TNF property.	Curcumin	46-54	tumor necrosis factor	Homo sapiens	95-98
28286973-5	2017	Moreover, introduction of constitutively active AKT1 abolished the inhibitory effect of curcumin on cell proliferation, migration, and restored the phosphorylation levels of 4E-BP1 and S6K1, suggesting that curcumin functions via suppressing IGF2-mediated AKT/mTOR signaling pathway.	Curcumin	207-215	AKT serine/threonine kinase 1	Homo sapiens	48-51
28405735-0	2017	Curcumin inhibits epigen and amphiregulin upregulated by 2,4,6-trinitrochlorobenzene associated with attenuation of skin swelling.	Curcumin	0-8	amphiregulin	Mus musculus	29-41
28405735-13	2017	Curcumin also attenuated TNCB-induced ERK phosphorylation and expression of EPGN and AREG genes.	Curcumin	0-8	mitogen-activated protein kinase 1	Mus musculus	38-41
28405735-13	2017	Curcumin also attenuated TNCB-induced ERK phosphorylation and expression of EPGN and AREG genes.	Curcumin	0-8	amphiregulin	Mus musculus	85-89
28286973-0	2017	Curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	90-93
28286973-0	2017	Curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	94-98
28595079-0	2017	Curcumin reduces the risk of chronic kidney damage in mice with nonalcoholic steatohepatitis by modulating endoplasmic reticulum stress and MAPK signaling.	Curcumin	0-8	mitogen-activated protein kinase 1	Mus musculus	140-144
28595079-6	2017	Furthermore, curcumin markedly decreased NAD(P)H oxidase subunits (p67phox, p47phox, p22phox), nitrotyrosine and CYP2E1 renal protein expression as well as reduced pro-inflammatory cytokine expression (TNFalpha, IL-1beta, IFNgamma).	Curcumin	13-21	tumor necrosis factor	Mus musculus	202-210
28595079-6	2017	Furthermore, curcumin markedly decreased NAD(P)H oxidase subunits (p67phox, p47phox, p22phox), nitrotyrosine and CYP2E1 renal protein expression as well as reduced pro-inflammatory cytokine expression (TNFalpha, IL-1beta, IFNgamma).	Curcumin	13-21	interleukin 1 beta	Mus musculus	212-220
28595079-6	2017	Furthermore, curcumin markedly decreased NAD(P)H oxidase subunits (p67phox, p47phox, p22phox), nitrotyrosine and CYP2E1 renal protein expression as well as reduced pro-inflammatory cytokine expression (TNFalpha, IL-1beta, IFNgamma).	Curcumin	13-21	interferon gamma	Mus musculus	222-230
28595079-9	2017	Taken together, our results suggest that curcumin preserves the renal function, probably by attenuating the ER stress mediated MAPK signaling.	Curcumin	41-49	mitogen-activated protein kinase 1	Mus musculus	127-131
28286973-2	2017	In this study, we report that curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway.	Curcumin	30-38	AKT serine/threonine kinase 1	Homo sapiens	120-123
28286973-2	2017	In this study, we report that curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway.	Curcumin	30-38	mechanistic target of rapamycin kinase	Homo sapiens	124-128
28286973-4	2017	Ectopic expression of IGF2 and IGF1R, but not IGF1, in bladder cancer cells restored this process, suggesting that IGF2 is a target of curcumin.	Curcumin	135-143	insulin like growth factor 1	Homo sapiens	31-35
28286973-5	2017	Moreover, introduction of constitutively active AKT1 abolished the inhibitory effect of curcumin on cell proliferation, migration, and restored the phosphorylation levels of 4E-BP1 and S6K1, suggesting that curcumin functions via suppressing IGF2-mediated AKT/mTOR signaling pathway.	Curcumin	88-96	AKT serine/threonine kinase 1	Homo sapiens	48-52
28286973-5	2017	Moreover, introduction of constitutively active AKT1 abolished the inhibitory effect of curcumin on cell proliferation, migration, and restored the phosphorylation levels of 4E-BP1 and S6K1, suggesting that curcumin functions via suppressing IGF2-mediated AKT/mTOR signaling pathway.	Curcumin	207-215	mechanistic target of rapamycin kinase	Homo sapiens	260-264
28286973-6	2017	In summary, our results reveal that suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway is one of the mechanisms of action of curcumin.	Curcumin	141-149	AKT serine/threonine kinase 1	Homo sapiens	76-79
28286973-6	2017	In summary, our results reveal that suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway is one of the mechanisms of action of curcumin.	Curcumin	141-149	mechanistic target of rapamycin kinase	Homo sapiens	80-84
28429187-8	2017	Curcumin upregulated the phosphorylation of insulin receptor substrate (IRS)-1 and protein kinase B (Akt) in the liver, enhanced insulin sensitivity, and reversed the metabolic abnormalities and depressive-like behaviors mentioned above.	Curcumin	0-8	insulin receptor substrate 1	Rattus norvegicus	44-78
28286973-5	2017	Moreover, introduction of constitutively active AKT1 abolished the inhibitory effect of curcumin on cell proliferation, migration, and restored the phosphorylation levels of 4E-BP1 and S6K1, suggesting that curcumin functions via suppressing IGF2-mediated AKT/mTOR signaling pathway.	Curcumin	88-96	AKT serine/threonine kinase 1	Homo sapiens	48-51
28286973-5	2017	Moreover, introduction of constitutively active AKT1 abolished the inhibitory effect of curcumin on cell proliferation, migration, and restored the phosphorylation levels of 4E-BP1 and S6K1, suggesting that curcumin functions via suppressing IGF2-mediated AKT/mTOR signaling pathway.	Curcumin	88-96	mechanistic target of rapamycin kinase	Homo sapiens	260-264
28286973-5	2017	Moreover, introduction of constitutively active AKT1 abolished the inhibitory effect of curcumin on cell proliferation, migration, and restored the phosphorylation levels of 4E-BP1 and S6K1, suggesting that curcumin functions via suppressing IGF2-mediated AKT/mTOR signaling pathway.	Curcumin	207-215	AKT serine/threonine kinase 1	Homo sapiens	48-52
28741112-3	2017	Until now, only two-scaffold triazinone and curcumin have been reported as BACE-1 and GSK-3beta dual inhibitors.	Curcumin	44-52	beta-secretase 1	Homo sapiens	75-81
28429187-8	2017	Curcumin upregulated the phosphorylation of insulin receptor substrate (IRS)-1 and protein kinase B (Akt) in the liver, enhanced insulin sensitivity, and reversed the metabolic abnormalities and depressive-like behaviors mentioned above.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	101-104
28536971-0	2017	Selection of P-Glycoprotein Inhibitor and Formulation of Combinational Nanoformulation Containing Selected Agent Curcumin and DOX for Reversal of Resistance in K562 Cells.	Curcumin	113-121	ATP binding cassette subfamily B member 1	Homo sapiens	13-27
28627596-0	2017	Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1beta is mediated by curcumin via inhibition of NF-kappaB signaling in rat chondrocytes.	Curcumin	119-127	interleukin 1 beta	Rattus norvegicus	86-103
28627596-8	2017	Curcumin was demonstrated to inhibit the IL-1beta-induced activation of NF-kappaB by suppressing IkappaBalpha phosphorylation and p65/RelA nuclear translocation.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	41-49
28627596-8	2017	Curcumin was demonstrated to inhibit the IL-1beta-induced activation of NF-kappaB by suppressing IkappaBalpha phosphorylation and p65/RelA nuclear translocation.	Curcumin	0-8	synaptotagmin 1	Rattus norvegicus	130-133
28627596-10	2017	CCK-8 assays revealed that co-treatment with curcumin resulted in increased proliferation in IL-1beta-treated chondrocytes.	Curcumin	45-53	interleukin 1 beta	Rattus norvegicus	93-101
28536971-6	2017	RESULTS: P-gp inhibitors such as biochanin-A and curcumin were marked suitable for combination with DOX.	Curcumin	49-57	ATP binding cassette subfamily B member 1	Homo sapiens	9-13
28728293-11	2017	In addition, the formation of acidic vesicular organelles in cytoplasm, conversion of LC3-I to LC3-II and increased levels of autophagy-related proteins Beclin1, Atg7 and Atg5-Atg12 were observed in curcumin-treated cells.	Curcumin	199-207	autophagy related 5	Homo sapiens	171-175
28930270-8	2017	Increase in ERK1/2 phosphorylation in response to leptin was reduced by the addition of quercetin, curcumin and EGCG.	Curcumin	99-107	mitogen-activated protein kinase 3	Homo sapiens	12-18
28785217-11	2017	Immunofluorescent staining further showed that curcumin treatment significantly increased the number of CD206+Iba1+ M2 microglia/macrophages and reduced the number of CD16+Iba1+ M1 cells 10 days after stroke.	Curcumin	47-55	Fc receptor, IgG, low affinity III	Mus musculus	167-171
28785217-12	2017	In vitro studies using the BV2 microglial cell line confirmed that curcumin inhibited lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma)-induced M1 polarization.	Curcumin	67-75	interferon gamma	Mus musculus	115-142
28785217-13	2017	Curcumin treatment concentration-dependently reduced the expression of pro-inflammatory cytokines, including TNF-alpha, IL-6 and IL-12p70, in the absence of any toxic effect on microglial cell survival.	Curcumin	0-8	tumor necrosis factor	Mus musculus	109-118
28785217-13	2017	Curcumin treatment concentration-dependently reduced the expression of pro-inflammatory cytokines, including TNF-alpha, IL-6 and IL-12p70, in the absence of any toxic effect on microglial cell survival.	Curcumin	0-8	interleukin 6	Mus musculus	120-124
28702620-0	2017	Nanoparticle delivery of curcumin induces cellular hypoxia and ROS-mediated apoptosis via modulation of Bcl-2/Bax in human neuroblastoma.	Curcumin	25-33	BCL2 apoptosis regulator	Homo sapiens	104-109
28702620-0	2017	Nanoparticle delivery of curcumin induces cellular hypoxia and ROS-mediated apoptosis via modulation of Bcl-2/Bax in human neuroblastoma.	Curcumin	25-33	BCL2 associated X, apoptosis regulator	Homo sapiens	110-113
28754004-0	2017	Synergistic Interplay between Curcumin and Polyphenol-Rich Foods in the Mediterranean Diet: Therapeutic Prospects for Neurofibromatosis 1 Patients.	Curcumin	30-38	neurofibromin 1	Homo sapiens	118-137
28754004-8	2017	We hypothesize that the combination of a polyphenol-rich Mediterranean diet and curcumin was responsible for the beneficial effect observed on NF1.	Curcumin	80-88	neurofibromin 1	Homo sapiens	143-146
28754004-9	2017	This is, to the best of our knowledge, the first experience with curcumin supplementation in NF1 patients.	Curcumin	65-73	neurofibromin 1	Homo sapiens	93-96
28728293-11	2017	In addition, the formation of acidic vesicular organelles in cytoplasm, conversion of LC3-I to LC3-II and increased levels of autophagy-related proteins Beclin1, Atg7 and Atg5-Atg12 were observed in curcumin-treated cells.	Curcumin	199-207	autophagy related 12	Homo sapiens	176-181
28728293-12	2017	Moreover, activation of PI3K/Akt/mTOR signaling pathway was also significantly suppressed after curcumin treatment.	Curcumin	96-104	AKT serine/threonine kinase 1	Homo sapiens	29-32
28728293-12	2017	Moreover, activation of PI3K/Akt/mTOR signaling pathway was also significantly suppressed after curcumin treatment.	Curcumin	96-104	mechanistic target of rapamycin kinase	Homo sapiens	33-37
28187447-6	2017	When the acetylation of H3K9 in the Egr-1 binding site was significantly reduced by the histone acetyltransferase (HAT) inhibitor curcumin, binding of Egr-1 to GDNF promoter II, RNA POL II recruitment, and GDNF mRNA expression were significantly downregulated (P &lt; 0.01).	Curcumin	130-138	glial cell derived neurotrophic factor	Homo sapiens	160-164
28187447-7	2017	Moreover, curcumin attenuated the effects of Egr-1 overexpression on Egr-1 binding, RNA POL II recruitment, and GDNF transcription (P &lt; 0.01).	Curcumin	10-18	glial cell derived neurotrophic factor	Homo sapiens	112-116
28684422-0	2017	WITHDRAWN: Curcumin shifts RAS-induced pro-proliferative MEK/ERK-signaling toward pro-apoptotic p38MAPK/JNK1-signaling, triggering p53 activation and apoptosis.	Curcumin	11-19	mitogen-activated protein kinase kinase 7	Homo sapiens	57-60
28399452-0	2017	Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death.	Curcumin	37-45	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65
28399452-1	2017	Activation of nuclear factor erythroid-2-related factor 2 (Nrf2) has been proven to be an effective means to prevent the development of cancer, and natural curcumin stands out as a potent Nrf2 activator and cancer chemopreventive agent.	Curcumin	156-164	NFE2 like bZIP transcription factor 2	Homo sapiens	188-192
28399452-2	2017	In this study, we synthesized a series of curcumin analogs by introducing the geminal dimethyl substituents on the active methylene group to find more potent Nrf2 activators and cytoprotectors against oxidative death.	Curcumin	42-50	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
28399452-6	2017	This work provides an example of successfully designing natural curcumin-directed Nrf2 activators by a stability-increasing and proelectrophilic strategy.	Curcumin	64-72	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
28684422-0	2017	WITHDRAWN: Curcumin shifts RAS-induced pro-proliferative MEK/ERK-signaling toward pro-apoptotic p38MAPK/JNK1-signaling, triggering p53 activation and apoptosis.	Curcumin	11-19	mitogen-activated protein kinase 1	Homo sapiens	61-64
28684422-0	2017	WITHDRAWN: Curcumin shifts RAS-induced pro-proliferative MEK/ERK-signaling toward pro-apoptotic p38MAPK/JNK1-signaling, triggering p53 activation and apoptosis.	Curcumin	11-19	mitogen-activated protein kinase 8	Homo sapiens	104-108
28684422-0	2017	WITHDRAWN: Curcumin shifts RAS-induced pro-proliferative MEK/ERK-signaling toward pro-apoptotic p38MAPK/JNK1-signaling, triggering p53 activation and apoptosis.	Curcumin	11-19	tumor protein p53	Homo sapiens	131-134
28235660-10	2017	Curcumin, another polyphenol, can suppress overexpression of inflammatory mediators via inhibiting the TLR4-MAPK/NF-kappaB pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	113-122
28611265-9	2017	RESULTS: Curcumin increased the survival percent in rats, decreased -fetoprotein (AFP) concentration, and serum aspartate aminotransferase (AST) activity, and increased serum albumin concentration.	Curcumin	9-17	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	112-138
28611265-9	2017	RESULTS: Curcumin increased the survival percent in rats, decreased -fetoprotein (AFP) concentration, and serum aspartate aminotransferase (AST) activity, and increased serum albumin concentration.	Curcumin	9-17	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	140-143
28539160-3	2017	Jab1 stimulated phosphorylation of p53 at T155 was inhibited by curcumin, an inhibitor of COP9 signalosome (CSN)-associated kinases.	Curcumin	64-72	tumor protein p53	Homo sapiens	35-38
28448872-7	2017	Furthermore, we found that curcumin up-regulated the expression of nuclear Nrf2 and Nrf2-dependent antioxidant defense genes including heme oxygenase-1 (HO-1), glutamate-cysteine ligase (GCLC), NAD(P)H dehydrogenase, and quinone (NQO-1) in a dose-dependent manner.	Curcumin	27-35	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	187-191
28448872-7	2017	Furthermore, we found that curcumin up-regulated the expression of nuclear Nrf2 and Nrf2-dependent antioxidant defense genes including heme oxygenase-1 (HO-1), glutamate-cysteine ligase (GCLC), NAD(P)H dehydrogenase, and quinone (NQO-1) in a dose-dependent manner.	Curcumin	27-35	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	230-235
28448872-8	2017	Our results showed that curcumin protected experimental animals against LPS/d-GalN-induced ALI through activation of Nrf2 nuclear translocation and inhibition of NF-kappaB activation.	Curcumin	24-32	galanin and GMAP prepropeptide	Rattus norvegicus	78-82
28448872-8	2017	Our results showed that curcumin protected experimental animals against LPS/d-GalN-induced ALI through activation of Nrf2 nuclear translocation and inhibition of NF-kappaB activation.	Curcumin	24-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	117-121
28448872-0	2017	Curcumin attenuates lipopolysaccharide/d-galactosamine-induced acute liver injury by activating Nrf2 nuclear translocation and inhibiting NF-kB activation.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	96-100
28448872-2	2017	In this study, the hepatoprotective effect of curcumin was investigated in lipopolysaccharide (LPS)/d-galactosamine (d-GalN)-induced acute liver injury (ALI) in rats.	Curcumin	46-54	galanin and GMAP prepropeptide	Rattus norvegicus	119-123
28448872-4	2017	Curcumin was administered once daily starting three days prior to LPS/d-GalN treatment.	Curcumin	0-8	galanin and GMAP prepropeptide	Rattus norvegicus	72-76
28448872-6	2017	Moreover, higher dosages of curcumin pretreatment inhibited NF-kappaB activation and reduced serum TNF-alpha and liver TNF-alpha levels induced by LPS/d-GalN ip injection.	Curcumin	28-36	tumor necrosis factor	Rattus norvegicus	99-108
28448872-6	2017	Moreover, higher dosages of curcumin pretreatment inhibited NF-kappaB activation and reduced serum TNF-alpha and liver TNF-alpha levels induced by LPS/d-GalN ip injection.	Curcumin	28-36	tumor necrosis factor	Rattus norvegicus	119-128
28448872-6	2017	Moreover, higher dosages of curcumin pretreatment inhibited NF-kappaB activation and reduced serum TNF-alpha and liver TNF-alpha levels induced by LPS/d-GalN ip injection.	Curcumin	28-36	galanin and GMAP prepropeptide	Rattus norvegicus	153-157
28448872-7	2017	Furthermore, we found that curcumin up-regulated the expression of nuclear Nrf2 and Nrf2-dependent antioxidant defense genes including heme oxygenase-1 (HO-1), glutamate-cysteine ligase (GCLC), NAD(P)H dehydrogenase, and quinone (NQO-1) in a dose-dependent manner.	Curcumin	27-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	75-79
28448872-7	2017	Furthermore, we found that curcumin up-regulated the expression of nuclear Nrf2 and Nrf2-dependent antioxidant defense genes including heme oxygenase-1 (HO-1), glutamate-cysteine ligase (GCLC), NAD(P)H dehydrogenase, and quinone (NQO-1) in a dose-dependent manner.	Curcumin	27-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	84-88
28495580-0	2017	Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates.	Curcumin	6-14	amyloid beta precursor protein	Homo sapiens	100-105
28218464-0	2017	Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	95-100
28672972-0	2017	JNK pathway mediates curcumin-induced apoptosis and autophagy in osteosarcoma MG63 cells.	Curcumin	21-29	mitogen-activated protein kinase 8	Homo sapiens	0-3
28672972-5	2017	Notably, inhibition of apoptosis enhanced curcumin-induced autophagy due to upregulation of the c-Jun N-terminal kinase (JNK) signaling pathway.	Curcumin	42-50	mitogen-activated protein kinase 8	Homo sapiens	96-119
28672972-5	2017	Notably, inhibition of apoptosis enhanced curcumin-induced autophagy due to upregulation of the c-Jun N-terminal kinase (JNK) signaling pathway.	Curcumin	42-50	mitogen-activated protein kinase 8	Homo sapiens	121-124
28258441-0	2017	TNF-alpha, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats.	Curcumin	78-86	interleukin 6	Rattus norvegicus	11-15
28258441-11	2017	Pre-treatment of curcumin reduced cisplatin-induced nephrotoxicity which was clearly evident from the reduced BUN, creatinine, TNF-alpha, IL-6 and IL-8 levels and increased albumin and IL-10 levels.	Curcumin	17-25	tumor necrosis factor	Rattus norvegicus	127-136
28258441-11	2017	Pre-treatment of curcumin reduced cisplatin-induced nephrotoxicity which was clearly evident from the reduced BUN, creatinine, TNF-alpha, IL-6 and IL-8 levels and increased albumin and IL-10 levels.	Curcumin	17-25	interleukin 6	Rattus norvegicus	138-142
28258441-14	2017	The disparity in the action of curcumin after pre- and post-treatment with cisplatin-induced nephrotoxicity was due to the inability of post-treatment to reduce TNF-alpha &amp; IL-6, besides to show a concurrent rise in IL-10 expression in renal tissues.	Curcumin	31-39	tumor necrosis factor	Rattus norvegicus	161-170
28258441-14	2017	The disparity in the action of curcumin after pre- and post-treatment with cisplatin-induced nephrotoxicity was due to the inability of post-treatment to reduce TNF-alpha &amp; IL-6, besides to show a concurrent rise in IL-10 expression in renal tissues.	Curcumin	31-39	interleukin 6	Rattus norvegicus	177-181
28495580-2	2017	Curcumin has been reported to display anti-amyloidogenic activity, not only by inhibiting the formation of new Abeta aggregates, but also by disaggregating existing ones.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	111-116
28495580-7	2017	Our results show no apparent toxicity of the formulated NPs, but a significant decrease of Abeta aggregates in response to Curcumin loaded NPs.	Curcumin	123-131	amyloid beta precursor protein	Homo sapiens	91-96
29029441-0	2017	Curcumin protects against hepatic ischemia/reperfusion induced injury through inhibiting TLR4/NF-kappaB pathway.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	89-93
29029441-2	2017	In this study, we reported a protective effect of curcumin against hepatic I/R injury via TLR4/NF-kappaB pathway.	Curcumin	50-58	toll-like receptor 4	Rattus norvegicus	90-94
29029441-3	2017	Curcumin significantly inhibited cell apoptosis, and decreased levels of LDH and production of TNF-a, IL-1b, and IL-6 in the cell supernatant.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	95-100
29029441-3	2017	Curcumin significantly inhibited cell apoptosis, and decreased levels of LDH and production of TNF-a, IL-1b, and IL-6 in the cell supernatant.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	102-107
29029441-3	2017	Curcumin significantly inhibited cell apoptosis, and decreased levels of LDH and production of TNF-a, IL-1b, and IL-6 in the cell supernatant.	Curcumin	0-8	interleukin 6	Rattus norvegicus	113-117
29029441-4	2017	In addition, curcumin ameliorated elevated TLR4 and NF-kappaB caused by hypoxia/reoxygenation stimulation in BRL-3A cells.	Curcumin	13-21	toll-like receptor 4	Rattus norvegicus	43-47
29029441-5	2017	In vivo assays revealed that curcumin reduce levels of ALT and AST, and reversed TLR4/NF-kappaB signaling pathway caused by hepatic I/R stimulation in liver tissues.	Curcumin	29-37	toll-like receptor 4	Rattus norvegicus	81-85
29029441-6	2017	These results suggested that curcumin ameliorates hepatic I/R injury, which may be mediated in part via the TLR4/NF-kappaB signaling pathway.	Curcumin	29-37	toll-like receptor 4	Rattus norvegicus	108-112
28478481-0	2017	The synergistic effects of omega-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-alpha gene expression and serum level in migraine patients.	Curcumin	56-64	tumor necrosis factor	Homo sapiens	84-117
28781948-0	2017	Curcumin suppresses gastric cancer by inhibiting gastrin-mediated acid secretion.	Curcumin	0-8	gastrin	Mus musculus	49-56
28781948-3	2017	The objective of this study was to investigate whether curcumin regulates gastrin-mediated acid secretion in suppressing gastric cancer.	Curcumin	55-63	gastrin	Mus musculus	74-81
28781948-10	2017	Curcumin also reduced gastrin secretion.	Curcumin	0-8	gastrin	Mus musculus	22-29
28781948-12	2017	In gastric cancer, curcumin suppresses gastrin-mediated acid secretion, which inhibits gastric cancer progression.	Curcumin	19-27	gastrin	Mus musculus	39-46
28730070-1	2017	AIM: To study the effects of curcumin on the secretion of interleukin (IL)-6 and IL-8 by corneal limbus epithelial cells.	Curcumin	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
28730070-9	2017	Curcumin at 5-20 micromol/L significantly inhibited UVB-induced secretion of IL-6 and IL-8 by limbus epithelial cells in a dose-dependent manner; while curcumin alone did not affect the secretion of IL-6 and IL-8.	Curcumin	0-8	interleukin 6	Homo sapiens	77-81
28730070-9	2017	Curcumin at 5-20 micromol/L significantly inhibited UVB-induced secretion of IL-6 and IL-8 by limbus epithelial cells in a dose-dependent manner; while curcumin alone did not affect the secretion of IL-6 and IL-8.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
28730070-9	2017	Curcumin at 5-20 micromol/L significantly inhibited UVB-induced secretion of IL-6 and IL-8 by limbus epithelial cells in a dose-dependent manner; while curcumin alone did not affect the secretion of IL-6 and IL-8.	Curcumin	0-8	interleukin 6	Homo sapiens	199-203
28730070-9	2017	Curcumin at 5-20 micromol/L significantly inhibited UVB-induced secretion of IL-6 and IL-8 by limbus epithelial cells in a dose-dependent manner; while curcumin alone did not affect the secretion of IL-6 and IL-8.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	208-212
28730070-10	2017	The upregulation of NF-kappaB and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-kappaB and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8.	Curcumin	104-112	nuclear factor kappa B subunit 1	Homo sapiens	20-29
28730070-10	2017	The upregulation of NF-kappaB and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-kappaB and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8.	Curcumin	104-112	nuclear factor kappa B subunit 1	Homo sapiens	130-139
28730070-10	2017	The upregulation of NF-kappaB and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-kappaB and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8.	Curcumin	104-112	interleukin 6	Homo sapiens	237-241
28730070-10	2017	The upregulation of NF-kappaB and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-kappaB and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8.	Curcumin	104-112	C-X-C motif chemokine ligand 8	Homo sapiens	246-250
28730070-10	2017	The upregulation of NF-kappaB and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-kappaB and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8.	Curcumin	199-207	nuclear factor kappa B subunit 1	Homo sapiens	20-29
28730070-10	2017	The upregulation of NF-kappaB and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-kappaB and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8.	Curcumin	199-207	nuclear factor kappa B subunit 1	Homo sapiens	130-139
28730070-10	2017	The upregulation of NF-kappaB and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-kappaB and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8.	Curcumin	199-207	interleukin 6	Homo sapiens	237-241
28730070-10	2017	The upregulation of NF-kappaB and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-kappaB and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8.	Curcumin	199-207	C-X-C motif chemokine ligand 8	Homo sapiens	246-250
28756925-11	2017	CONCLUSIONS: Curcumin can significantly improve the symptoms of chronic urinary tract infections, protect renal tubular function, and also decline inflammatory responses by influencing the expressions of TLR2 mRNA and TLR4 mRNA so as to exert its curative effect on chronic urinary tract infections.	Curcumin	13-21	toll-like receptor 2	Rattus norvegicus	204-208
28756925-11	2017	CONCLUSIONS: Curcumin can significantly improve the symptoms of chronic urinary tract infections, protect renal tubular function, and also decline inflammatory responses by influencing the expressions of TLR2 mRNA and TLR4 mRNA so as to exert its curative effect on chronic urinary tract infections.	Curcumin	13-21	toll-like receptor 4	Rattus norvegicus	218-222
28289922-10	2017	Significant inhibition in mRNA expression of iNOS, TGF-beta1 and TNF-alpha level was noted after curcumin treatment along with lowered MPO activity, inflammatory cell count, ROS, nitrite levels and collagen deposition in lungs.	Curcumin	97-105	nitric oxide synthase 2, inducible	Mus musculus	45-49
28289922-10	2017	Significant inhibition in mRNA expression of iNOS, TGF-beta1 and TNF-alpha level was noted after curcumin treatment along with lowered MPO activity, inflammatory cell count, ROS, nitrite levels and collagen deposition in lungs.	Curcumin	97-105	tumor necrosis factor	Mus musculus	65-74
28463091-8	2017	Curcumin (CCM) could rescue EMT process induced by gamma-irradiation via the suppression of Gli1 and the upregulation of Sufu.	Curcumin	0-8	SUFU negative regulator of hedgehog signaling	Homo sapiens	121-125
28587282-1	2017	The purpose of this study is to determine if a preventive treatment with curcumin can protect intestinal epithelial cells from inflammatory damage induced by IFNgamma.	Curcumin	73-81	interferon gamma	Homo sapiens	158-166
28587282-3	2017	In this model, we measured the effect of curcumin (curcuminoid from Curcuma Longa) added as a pre-treatment at different time intervals before stimulation with IFNgamma.	Curcumin	41-49	interferon gamma	Homo sapiens	160-168
28587282-4	2017	Curcumin administration to HT29 culture before the inflammatory stimulus IFNgamma reduced the cell apoptosis rate.	Curcumin	0-8	interferon gamma	Homo sapiens	73-81
28587282-6	2017	This anti-apoptotic action by curcumin pre-treatment was paralleled by a reduction of secreted IL7 in the HT29 culture media, while there was no relevant change in the other cytokine levels.	Curcumin	30-38	interleukin 7	Homo sapiens	95-98
28587210-0	2017	Curcumin Inhibits LIN-28A through the Activation of miRNA-98 in the Lung Cancer Cell Line A549.	Curcumin	0-8	lin-28 homolog A	Homo sapiens	18-25
28587210-4	2017	Curcumin treatment enhanced the expression of miR-98 and reduced that of the miR-98 target gene LIN28A as well as matrix metalloproteinase (MMP) 2 and MMP9 in vitro and in vivo.	Curcumin	0-8	lin-28 homolog A	Homo sapiens	96-102
28587210-7	2017	Induction of miR-98 by curcumin treatment suppressed MMP2 and MMP9 by targeting LIN28A.	Curcumin	23-31	lin-28 homolog A	Homo sapiens	80-86
28289922-0	2017	Curcumin inhibits lipopolysaccharide (LPS)-induced endotoxemia and airway inflammation through modulation of sequential release of inflammatory mediators (TNF-alpha and TGF-beta1) in murine model.	Curcumin	0-8	tumor necrosis factor	Mus musculus	155-164
28274864-0	2017	Protective effects of curcumin against gamma ray induced conformational change of human serum albumin.	Curcumin	22-30	albumin	Homo sapiens	88-101
28274864-1	2017	This study explores the possibility for protection by curcumin during the molecular and structural changes of human serum albumin (HSA) exposed to gamma irradiation.	Curcumin	54-62	albumin	Homo sapiens	116-129
28478481-4	2017	omega-3 fatty acids and curcumin exert neuroprotective and anti-inflammatory effects via several mechanisms including suppression of TNF-alpha gene expression and its serum levels.	Curcumin	24-32	tumor necrosis factor	Homo sapiens	133-142
28478481-5	2017	The aim of this study is an evaluation of synergistic effects of omega-3 fatty acids and nano-curcumin on TNF-alpha gene expression and serum levels in migraine patients.	Curcumin	94-102	tumor necrosis factor	Homo sapiens	106-115
28478481-8	2017	Our results showed that the combination of omega-3 fatty acids and nano-curcumin downregulated TNF-alpha messenger RNA (mRNA) significantly in a synergistic manner (P &lt; 0.05).	Curcumin	72-80	tumor necrosis factor	Homo sapiens	95-104
28415461-0	2017	A new bioavailability enhancement strategy of curcumin via self-assembly nano-complexation of curcumin and bovine serum albumin.	Curcumin	46-54	albumin	Homo sapiens	114-127
28605812-11	2017	Similarly, curcumin also inhibited TGFbeta1-induced Smad3 phosphorylation, Nox4-derived H2O2 production, and total collagen synthesis by conjunctival fibroblasts (P &lt; 0.05; n = 4-6).	Curcumin	11-19	NADPH oxidase 4	Oryctolagus cuniculus	75-79
28605812-12	2017	Conclusions: The present study suggests that TGFbeta1-mediated production of collagen by conjunctival fibroblasts involves Nox4-derived H2O2 pathway and this effect of Nox4 is abrogated by curcumin.	Curcumin	189-197	NADPH oxidase 4	Oryctolagus cuniculus	168-172
28402926-5	2017	Curcumin suppressed the migration rate of Ishikawa and Hec-1B cells as analyzed by scratch wound assay.	Curcumin	0-8	NDC80 kinetochore complex component	Homo sapiens	55-60
26651837-0	2017	Neuroprotective effects of curcumin on endothelin-1 mediated cell death in hippocampal neurons.	Curcumin	27-35	endothelin 1	Homo sapiens	39-51
26651837-5	2017	The objective of this study was to determine if curcumin could protect hippocampal neurons from ET-1 mediated cell death and examine the involvement of c-Jun in this pathway.	Curcumin	48-56	endothelin 1	Rattus norvegicus	96-100
26651837-11	2017	Co-treatment with curcumin significantly attenuated the ET-1 mediated increase in c-Jun levels.	Curcumin	18-26	endothelin 1	Rattus norvegicus	56-60
26651837-12	2017	ET-1 caused increased neuronal cell death of hippocampal neurons indicated by elevation of cleaved caspase-3, cleaved fodrin and an increased activity of caspases 3 and 7 which was attenuated by co-treatment with curcumin.	Curcumin	213-221	endothelin 1	Rattus norvegicus	0-4
26651837-12	2017	ET-1 caused increased neuronal cell death of hippocampal neurons indicated by elevation of cleaved caspase-3, cleaved fodrin and an increased activity of caspases 3 and 7 which was attenuated by co-treatment with curcumin.	Curcumin	213-221	caspase 3	Homo sapiens	99-108
26651837-12	2017	ET-1 caused increased neuronal cell death of hippocampal neurons indicated by elevation of cleaved caspase-3, cleaved fodrin and an increased activity of caspases 3 and 7 which was attenuated by co-treatment with curcumin.	Curcumin	213-221	caspase 3	Homo sapiens	154-170
26651837-14	2017	DISCUSSION: Our data suggests that one mechanism by which curcumin protects against ET-1-mediated cell death is through blocking an increase in c-Jun levels.	Curcumin	58-66	endothelin 1	Rattus norvegicus	84-88
28599484-0	2017	Anticancer effect of curcumin inhibits cell growth through miR-21/PTEN/Akt pathway in breast cancer cell.	Curcumin	21-29	AKT serine/threonine kinase 1	Homo sapiens	71-74
28599484-10	2017	The present results demonstrated that curcumin inhibited cell viability and induced cytotoxicity of MCF-7 cells in a concentration- and time-dependent manner, by inducing apoptosis and increasing caspase-3/9 activities.	Curcumin	38-46	caspase 3	Homo sapiens	196-205
28599484-11	2017	In addition, curcumin downregulated miR-21 expression in MCF-7 cells by upregulating the PTEN/Akt signaling pathway.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	94-97
28599484-12	2017	The present study has for the first time, to the best of our knowledge, revealed the anticancer effect of curcumin in suppressing breast cancer cell growth, and has elucidated that the miR-21/PTEN/Akt signaling pathway is a key mechanism for the anticancer effects of curcumin.	Curcumin	106-114	AKT serine/threonine kinase 1	Homo sapiens	197-200
28599484-12	2017	The present study has for the first time, to the best of our knowledge, revealed the anticancer effect of curcumin in suppressing breast cancer cell growth, and has elucidated that the miR-21/PTEN/Akt signaling pathway is a key mechanism for the anticancer effects of curcumin.	Curcumin	268-276	AKT serine/threonine kinase 1	Homo sapiens	197-200
28485571-7	2017	Under the optimized conditions, the developed UCNPs-curcumin mixed system achieved the colorimetric and ratiometric fluorescence sensing toward F- in the linear range of 25-200 muM and 5-200 muM, with the detection limits as low as 25 muM (ca.	Curcumin	52-60	latexin	Homo sapiens	177-180
31682378-3	2017	RESULTS: Compared with the effects of either agent alone, the combination of curcumin and gefitinib had a stronger suppressive effect on proliferation and the clonogenic capacity (P &lt; 0.05), and showed an increased ability to promote apoptosis (P &lt; 0.05) and reduce p38, ERK1/2, and AKT phosphorylation (P &lt; 0.05).	Curcumin	77-85	mitogen-activated protein kinase 1	Homo sapiens	272-275
31682378-3	2017	RESULTS: Compared with the effects of either agent alone, the combination of curcumin and gefitinib had a stronger suppressive effect on proliferation and the clonogenic capacity (P &lt; 0.05), and showed an increased ability to promote apoptosis (P &lt; 0.05) and reduce p38, ERK1/2, and AKT phosphorylation (P &lt; 0.05).	Curcumin	77-85	mitogen-activated protein kinase 3	Homo sapiens	277-283
31682378-3	2017	RESULTS: Compared with the effects of either agent alone, the combination of curcumin and gefitinib had a stronger suppressive effect on proliferation and the clonogenic capacity (P &lt; 0.05), and showed an increased ability to promote apoptosis (P &lt; 0.05) and reduce p38, ERK1/2, and AKT phosphorylation (P &lt; 0.05).	Curcumin	77-85	AKT serine/threonine kinase 1	Homo sapiens	289-292
28498433-8	2017	Activation of the PI3K/Akt/mTOR signaling pathway was suppressed in gastric cancer cells with curcumin treatment.	Curcumin	94-102	AKT serine/threonine kinase 1	Homo sapiens	23-26
28498433-8	2017	Activation of the PI3K/Akt/mTOR signaling pathway was suppressed in gastric cancer cells with curcumin treatment.	Curcumin	94-102	mechanistic target of rapamycin kinase	Homo sapiens	27-31
28485571-7	2017	Under the optimized conditions, the developed UCNPs-curcumin mixed system achieved the colorimetric and ratiometric fluorescence sensing toward F- in the linear range of 25-200 muM and 5-200 muM, with the detection limits as low as 25 muM (ca.	Curcumin	52-60	latexin	Homo sapiens	191-194
28485571-7	2017	Under the optimized conditions, the developed UCNPs-curcumin mixed system achieved the colorimetric and ratiometric fluorescence sensing toward F- in the linear range of 25-200 muM and 5-200 muM, with the detection limits as low as 25 muM (ca.	Curcumin	52-60	latexin	Homo sapiens	191-194
28579781-11	2017	Moreover, filaments with 10% curcumin increase the catalase activity and glutathione content in NHDFs, indicating an increased production of reactive oxygen species resulting from the large concentration of curcumin.	Curcumin	29-37	catalase	Homo sapiens	51-59
28579781-11	2017	Moreover, filaments with 10% curcumin increase the catalase activity and glutathione content in NHDFs, indicating an increased production of reactive oxygen species resulting from the large concentration of curcumin.	Curcumin	207-215	catalase	Homo sapiens	51-59
28579781-10	2017	Highly dosed filaments induce either the inhibition of proliferation (with 1%) or cell apoptosis (with 10%) as a result of the concentrations of curcumin found in the medium (9 and 32 muM, respectively), which are near or above the known toxicity threshold of curcumin (~10 muM).	Curcumin	145-153	latexin	Homo sapiens	184-187
29088758-7	2017	Thus, we concluded that miR-378 enhances the response of glioblastoma multiforme to curcumin treatment, by targeting p38.	Curcumin	84-92	mitogen-activated protein kinase 14	Homo sapiens	117-120
28579805-4	2017	Thus, we hypothesized that bisdemethoxycurcumin, a natural dimethoxy derivative of curcumin, may provide a favorable environment for T-cell response against bladder cancer when used in combination with alpha-PD-L1 antibody.	Curcumin	39-47	CD274 antigen	Mus musculus	208-213
28274615-10	2017	Oxidative transformation by leukocyte myeloperoxidase may represent a novel metabolic pathway of curcumin and its glucuronide conjugate.	Curcumin	97-105	myeloperoxidase	Homo sapiens	38-53
29926590-14	2017	CONCLUSIONS: Curcumin can promote the recovery of hindlimb motor function after spinal cord injury in rats.The mechanism is through inhibition of NF-K B to prevent inflammation; And inhibition the expression of Bax and Caspase-3, and promotion the expression of Bcl-2 to prevent apoptosis, so as to accelerate the recovery of motor function in the rats after spinal cord injury.	Curcumin	13-21	BCL2, apoptosis regulator	Rattus norvegicus	262-267
28485773-4	2017	In a dorsal root ganglion (DRG) culture, curcumin effectively inhibited TNF-alpha-induced neuroinflammation, in a dose-dependent manner, as shown by mRNA and protein expression of IL-6 and COX-2.	Curcumin	41-49	tumor necrosis factor	Mus musculus	72-81
28485773-4	2017	In a dorsal root ganglion (DRG) culture, curcumin effectively inhibited TNF-alpha-induced neuroinflammation, in a dose-dependent manner, as shown by mRNA and protein expression of IL-6 and COX-2.	Curcumin	41-49	interleukin 6	Mus musculus	180-184
28485773-7	2017	In addition, curcumin protected neurons from TNF-alpha-triggered excessive reactive oxygen species (ROS) production and cellular apoptosis and, accordingly, promoted mRNA expression of the anti-oxidative enzymes haem oxygenase-1, catalase and superoxide dismutase-2.	Curcumin	13-21	tumor necrosis factor	Mus musculus	45-54
28485773-7	2017	In addition, curcumin protected neurons from TNF-alpha-triggered excessive reactive oxygen species (ROS) production and cellular apoptosis and, accordingly, promoted mRNA expression of the anti-oxidative enzymes haem oxygenase-1, catalase and superoxide dismutase-2.	Curcumin	13-21	catalase	Mus musculus	217-238
28198010-2	2017	Curcumin exerts anti-inflammatory functions by interfering with LPS-induced dimerization of TLR4-myeloid differentiation protein-2 (MD-2) complex and suppressing pro-inflammatory mediator release.	Curcumin	0-8	toll-like receptor 4	Mus musculus	92-96
28423731-3	2017	The faster release of curcumin from the folate-conjugated curcumin and paclitaxel-loaded lipid nanoparticles enables sufficient p-glycoprotein inhibition, which allows increased cellular uptake and cytotoxicity of paclitaxel.	Curcumin	22-30	ATP binding cassette subfamily B member 1	Homo sapiens	128-142
28423731-3	2017	The faster release of curcumin from the folate-conjugated curcumin and paclitaxel-loaded lipid nanoparticles enables sufficient p-glycoprotein inhibition, which allows increased cellular uptake and cytotoxicity of paclitaxel.	Curcumin	58-66	ATP binding cassette subfamily B member 1	Homo sapiens	128-142
28423731-4	2017	In western blot assay, curcumin can efficiently inhibit the expression of p-glycoprotein, conformed the enhancement of cytotoxicity by paclitaxel.	Curcumin	23-31	ATP binding cassette subfamily B member 1	Homo sapiens	74-88
27002641-0	2017	Controlled release of curcumin from poly(HEMA-MAPA) membrane.	Curcumin	22-30	leucine rich repeat containing 25	Homo sapiens	46-50
28198010-8	2017	However, only curcumin and GG6, both possessing the 1,3-diketone moiety, inhibited LPS-induced TLR4 dimerization, activation of NF-kappaB and secretion of pro-inflammatory cytokines in primary microglia.	Curcumin	14-22	toll-like receptor 4	Mus musculus	95-99
28391351-8	2017	Since FOXD3 is important in the regulation of miR-143, we explored whether curcumin regulated FOXD3 expression.	Curcumin	75-83	forkhead box D3	Homo sapiens	94-99
28391351-9	2017	FOXD3 was also ectopically overexpressed to investigate its effects on curcumin"s regulation of miR-143.	Curcumin	71-79	forkhead box D3	Homo sapiens	0-5
28391351-0	2017	Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axis.	Curcumin	0-8	forkhead box D3	Homo sapiens	59-64
28391351-14	2017	Ectopic expression of FOXD3 synergized with curcumin in upregulating miR-143 expression.	Curcumin	44-52	forkhead box D3	Homo sapiens	22-27
28391351-2	2017	The objective of this study was to explore the interaction between curcumin and PGK1, an oncogene in the FOXD3/miR-143 axis, in prostate cancer therapy.	Curcumin	67-75	forkhead box D3	Homo sapiens	105-110
28391351-16	2017	PGK1 is downregulated by miR-143, and FOXD3 upregulation is essential for the antitumor effect of curcumin.	Curcumin	98-106	forkhead box D3	Homo sapiens	38-43
28273557-6	2017	Treatment with curcumin significantly reduced IL-6 and IL-23 production by dendritic cells (DC).	Curcumin	15-23	interleukin 6	Mus musculus	46-50
28216009-2	2017	C. gigas were exposed to waterborne 10 and 30muM curcumin, a known inducer of the mammalian Nrf2.	Curcumin	49-57	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
28216009-8	2017	However, the conserved sequences belonging to typical Nrf2 and Keap1 domains, and the notorious induction of antioxidant defense-related genes known to be controlled by Nrf2 in mammals, indicates a functional Nrf2/Keap1 pathway in bivalves, and curcumin seems to be a new tool to investigate the antioxidant response in bivalves.	Curcumin	245-253	NFE2 like bZIP transcription factor 2	Homo sapiens	169-173
28216009-8	2017	However, the conserved sequences belonging to typical Nrf2 and Keap1 domains, and the notorious induction of antioxidant defense-related genes known to be controlled by Nrf2 in mammals, indicates a functional Nrf2/Keap1 pathway in bivalves, and curcumin seems to be a new tool to investigate the antioxidant response in bivalves.	Curcumin	245-253	NFE2 like bZIP transcription factor 2	Homo sapiens	169-173
28339004-5	2017	In the present study, we used the X-ray crystallographic structure of p38alpha for molecular docking simulations and molecular dynamic simulations to study the binding modes of curcumin and its derivatives with the active site of p38alpha.	Curcumin	177-185	mitogen-activated protein kinase 14	Homo sapiens	70-78
28339004-5	2017	In the present study, we used the X-ray crystallographic structure of p38alpha for molecular docking simulations and molecular dynamic simulations to study the binding modes of curcumin and its derivatives with the active site of p38alpha.	Curcumin	177-185	mitogen-activated protein kinase 14	Homo sapiens	230-238
28339005-0	2017	Curcumin inhibits angiotensin II-induced inflammation and proliferation of rat vascular smooth muscle cells by elevating PPAR-gamma activity and reducing oxidative stress.	Curcumin	0-8	angiotensinogen	Rattus norvegicus	18-32
26956464-0	2017	Curcumin reduces cardiac fibrosis by inhibiting myofibroblast differentiation and decreasing transforming growth factor beta1 and matrix metalloproteinase 9 / tissue inhibitor of metalloproteinase 1.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	93-125
26956464-10	2017	Curcumin also inhibited fibrosis by inhibiting myofibroblast differentiation, decreased TGF-beta1, MMP-9 and TIMP-1 expression (P&lt;0.05) but had no effects on Smad3 in Ang II incubated cardiac fibroblasts.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	88-97
26956464-11	2017	CONCLUSIONS: Curcumin reduces cardiac fibrosis in rats and Ang II-induced fibroblast proliferation by inhibiting myofibroblast differentiation, decreasing collagen synthesis and accelerating collagen degradation through reduction of TGF-beta1, MMPs/TIMPs.	Curcumin	13-21	transforming growth factor, beta 1	Rattus norvegicus	233-242
28089916-0	2017	Stable curcumin-loaded polymeric micellar formulation for enhancing cellular uptake and cytotoxicity to FLT3 overexpressing EoL-1 leukemic cells.	Curcumin	7-15	fms related receptor tyrosine kinase 3	Homo sapiens	104-108
28393179-0	2017	Efficacy of curcumin in inducing apoptosis and inhibiting the expression of VEGF in human pterygium fibroblasts.	Curcumin	12-20	vascular endothelial growth factor A	Homo sapiens	76-80
28393179-10	2017	Our findings thus suggest that curcumin suppress cell proliferation in the pterygium by inducing HPF apoptosis and inhibiting VEGF expression.	Curcumin	31-39	vascular endothelial growth factor A	Homo sapiens	126-130
28273557-12	2017	We first reported that curcumin increased the mGluR4 expression in mouse BMDC activated with LPS, which likely contributed to the mechanism of inhibiting the Th17 cell differentiation.	Curcumin	23-31	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	46-52
28300666-3	2017	Previous studies have suggested curcumin as a safe phytochemical which can improve obesity-related insulin resistance, inflammation and oxidative stress.	Curcumin	32-40	insulin	Homo sapiens	99-106
28387563-7	2017	Since curcumin and SIRT3 both improve mitochondrial function and AO defense, SIRT3 may be involved in the protective effects of curcumin.	Curcumin	128-136	sirtuin 3	Homo sapiens	19-24
28387563-7	2017	Since curcumin and SIRT3 both improve mitochondrial function and AO defense, SIRT3 may be involved in the protective effects of curcumin.	Curcumin	128-136	sirtuin 3	Homo sapiens	77-82
28430129-0	2017	Curcumin Inhibits Apoptosis of Chondrocytes through Activation ERK1/2 Signaling Pathways Induced Autophagy.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	63-69
28430129-5	2017	In the present study, we investigated the protective mechanisms of curcumin on interleukin 1beta (IL-1beta)-stimulated primary chondrocytes in vitro.	Curcumin	67-75	interleukin 1 beta	Homo sapiens	79-96
28430129-5	2017	In the present study, we investigated the protective mechanisms of curcumin on interleukin 1beta (IL-1beta)-stimulated primary chondrocytes in vitro.	Curcumin	67-75	interleukin 1 beta	Homo sapiens	98-106
28430129-7	2017	Co-treatment of curcumin with IL-1beta significantly decreased the growth inhibition.	Curcumin	16-24	interleukin 1 beta	Homo sapiens	30-38
28430129-8	2017	We observed that curcumin inhibited IL-1beta-induced apoptosis and caspase-3 activation in chondrocytes.	Curcumin	17-25	interleukin 1 beta	Homo sapiens	36-44
28430129-8	2017	We observed that curcumin inhibited IL-1beta-induced apoptosis and caspase-3 activation in chondrocytes.	Curcumin	17-25	caspase 3	Homo sapiens	67-76
28430129-9	2017	Curcumin can increase the expression of phosphorylated extracellular signal-regulated kinases 1/2 (ERK1/2), autophagy marker light chain 3 (LC3)-II, and Beclin-1 in chondrocytes.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	55-97
28430129-9	2017	Curcumin can increase the expression of phosphorylated extracellular signal-regulated kinases 1/2 (ERK1/2), autophagy marker light chain 3 (LC3)-II, and Beclin-1 in chondrocytes.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	99-105
28430129-11	2017	Our results suggest that curcumin suppresses apoptosis and inflammatory signaling through its actions on the ERK1/2-induced autophagy in chondrocytes.	Curcumin	25-33	mitogen-activated protein kinase 3	Homo sapiens	109-115
28387563-3	2017	We postulated that curcumin increases AO defense under hyperglycemic conditions in HepG2 cells through SIRT3-mediated mechanisms.	Curcumin	19-27	sirtuin 3	Homo sapiens	103-108
28439402-5	2017	Curcumin also decreased the cleaved caspase-3 (CC3) protein expression level and increased the Bcl-2/Bax ratio in H2O2-stimulated H9c2 cells.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	95-100
28469791-9	2017	The results also revealed that Foxp3 bound T-bet to prevent IFN-gamma expression in CD4+ T cells, which was abolished by treating with curcumin.	Curcumin	135-143	interferon gamma	Homo sapiens	60-69
28469791-10	2017	In conclusion, the administration of curcumin can convert Tregs to Th1 cells via repressing Foxp3 expression and enhancing IFN-gamma production.	Curcumin	37-45	interferon gamma	Homo sapiens	123-132
28300666-0	2017	Curcumin attenuates BPA-induced insulin resistance in HepG2 cells through suppression of JNK/p38 pathways.	Curcumin	0-8	insulin	Homo sapiens	32-39
28300666-0	2017	Curcumin attenuates BPA-induced insulin resistance in HepG2 cells through suppression of JNK/p38 pathways.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	89-92
28300666-0	2017	Curcumin attenuates BPA-induced insulin resistance in HepG2 cells through suppression of JNK/p38 pathways.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	93-96
28300666-4	2017	The present study aimed to investigate the ability of curcumin to prevent BPA-induced insulin resistance in vitro and the underlying mechanism.	Curcumin	54-62	insulin	Homo sapiens	86-93
28300666-5	2017	Following the establishmet of in vitro insulin resistance via BPA treatment in human liver HepG2 cells, the protective effects of curcumin were determiend.	Curcumin	130-138	insulin	Homo sapiens	39-46
28300666-7	2017	Moreover, we revealed that curcumin effectively attenuated the spectrum of effects of BPA-triggered insulin resistance, whereas pretreatment with JNK and p38 agonist anisomycin could significantly compensate the effects caused by curcumin.	Curcumin	27-35	insulin	Homo sapiens	100-107
28300666-7	2017	Moreover, we revealed that curcumin effectively attenuated the spectrum of effects of BPA-triggered insulin resistance, whereas pretreatment with JNK and p38 agonist anisomycin could significantly compensate the effects caused by curcumin.	Curcumin	230-238	mitogen-activated protein kinase 8	Homo sapiens	146-149
28300666-7	2017	Moreover, we revealed that curcumin effectively attenuated the spectrum of effects of BPA-triggered insulin resistance, whereas pretreatment with JNK and p38 agonist anisomycin could significantly compensate the effects caused by curcumin.	Curcumin	230-238	mitogen-activated protein kinase 14	Homo sapiens	154-157
28300666-8	2017	These data illustrated the role of JNK/p38 activation in BPA-induced insulin resistance and suggested curcumin as a promising candidate for the intervention of BPA-induced insulin resistance.	Curcumin	102-110	insulin	Homo sapiens	172-179
28152473-0	2017	Combination of arabinogalactan and curcumin induces apoptosis in breast cancer cells in vitro and inhibits tumor growth via overexpression of p53 level in vivo.	Curcumin	35-43	tumor protein p53	Homo sapiens	142-145
28399135-0	2017	Structure based comprehensive modelling, spatial fingerprints mapping and ADME screening of curcumin analogues as novel ALR2 inhibitors.	Curcumin	92-100	aldo-keto reductase family 1 member B	Homo sapiens	120-124
28399135-4	2017	The literature evidenced that naturally occurring curcumin demonstrates relatively specific and non-competitive inhibition towards human recombinant ALR2 over ALR1 and AKR1B10; however beta-diketone moiety of curcumin is a specific substrate for liver AKRs and accountable for it"s rapid in vivo metabolism.	Curcumin	50-58	aldo-keto reductase family 1 member B	Homo sapiens	149-153
28399135-4	2017	The literature evidenced that naturally occurring curcumin demonstrates relatively specific and non-competitive inhibition towards human recombinant ALR2 over ALR1 and AKR1B10; however beta-diketone moiety of curcumin is a specific substrate for liver AKRs and accountable for it"s rapid in vivo metabolism.	Curcumin	209-217	aldo-keto reductase family 1 member B	Homo sapiens	149-153
28399135-5	2017	In the present study, structure based comprehensive modelling studies were used to map the pharmacophoric features/spatial fingerprints of curcumin analogues responsible for their ALR2 specificity along with potency on a data set of synthetic curcumin analogues and naturally occurring curcuminoids.	Curcumin	139-147	aldo-keto reductase family 1 member B	Homo sapiens	180-184
28399135-5	2017	In the present study, structure based comprehensive modelling studies were used to map the pharmacophoric features/spatial fingerprints of curcumin analogues responsible for their ALR2 specificity along with potency on a data set of synthetic curcumin analogues and naturally occurring curcuminoids.	Curcumin	243-251	aldo-keto reductase family 1 member B	Homo sapiens	180-184
28399135-6	2017	The data set molecules were also screened for drug-likeness or ADME parameters, and the screening data strongly support that curcumin analogues could be proposed as a good drug candidate for the development of ALR2 inhibitors with improved pharmacokinetic profile compared to curcuminoids due to the absence of beta-diketone moiety in their structural framework.	Curcumin	125-133	aldo-keto reductase family 1 member B	Homo sapiens	210-214
28122302-2	2017	In this report, we designed EGFR peptide decorated nanoparticles (NPs) to co-deliver docetaxel (DTX) and pH sensitive curcumin (CUR) prodrug for the treatment of prostate cancer.	Curcumin	118-126	epidermal growth factor receptor	Homo sapiens	28-32
28881600-0	2017	Curcumin induces G2/M cell cycle arrest and apoptosis of head and neck squamous cell carcinoma in vitro and in vivo through ATM/Chk2/p53-dependent pathway.	Curcumin	0-8	tumor protein p53	Homo sapiens	133-136
28249988-7	2017	Pretreatment with curcumin significantly attenuated LPS-induced secretion of master cytokine IL-1beta from IECs and macrophages.	Curcumin	18-26	interleukin 1 beta	Homo sapiens	93-101
28249988-8	2017	Furthermore, curcumin also reduced IL-1beta-induced activation of p38 MAPK in IECs and subsequent increase in expression of myosin light chain kinase involved in the phosphorylation of tight junction proteins and ensuing disruption of their normal arrangement.	Curcumin	13-21	interleukin 1 beta	Homo sapiens	35-43
28259934-11	2017	In conclusion, the present study revealed the positive role of ERK5/AP-1 in benzidine-provoked urocystic EMT and the curcumin promising use in bladder cancer prevention and intervention via ERK5/AP-1 pathway.	Curcumin	117-125	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	195-199
28204864-3	2017	One of the most promising CSAIDs is curcumin, which modulates the activity of several transcription factors (e.g., STAT, NF-kappaB, AP-1) and their pro-inflammatory molecular signaling pathways.	Curcumin	36-44	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-136
28167449-5	2017	Pharmacological activity of curcumin is mediated by modulation of several pathways, such as JAK-2/STAT3, thus inhibiting melanoma cell migration and invasion and enhancing apoptosis of these cells.	Curcumin	28-36	signal transducer and activator of transcription 3	Homo sapiens	98-103
28259934-0	2017	Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells.	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	94-98
28259934-10	2017	Furthermore, curcumin effectively attenuated benzidine-induced urocystic EMT by suppressing ERK5/AP-1 pathway.	Curcumin	13-21	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	97-101
27819148-4	2017	Curcumin was encapsulated in cationic liposomes and then complexed with STAT3 siRNA.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	72-77
29515638-2	2017	The current study hypothesized that curcumin downregulates HER-2 and inhibits the signal transduction pathway of PI3K/Akt, MAPK, and activation of NFkappaB, which could be useful to treat overexpressed-HER-2 hepatocellular carcinoma (HCC).	Curcumin	36-44	thymoma viral proto-oncogene 1	Mus musculus	118-121
29515638-2	2017	The current study hypothesized that curcumin downregulates HER-2 and inhibits the signal transduction pathway of PI3K/Akt, MAPK, and activation of NFkappaB, which could be useful to treat overexpressed-HER-2 hepatocellular carcinoma (HCC).	Curcumin	36-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	147-155
27819148-9	2017	The co-delivery of curcumin and STAT3 siRNA using liposomes resulted in significantly (p &lt; .05) greater cancer cell growth inhibition and apoptosis events compared with neat curcumin and free STAT3 siRNA treatment.	Curcumin	19-27	signal transducer and activator of transcription 3	Homo sapiens	195-200
27819148-9	2017	The co-delivery of curcumin and STAT3 siRNA using liposomes resulted in significantly (p &lt; .05) greater cancer cell growth inhibition and apoptosis events compared with neat curcumin and free STAT3 siRNA treatment.	Curcumin	177-185	signal transducer and activator of transcription 3	Homo sapiens	32-37
28377722-11	2017	Our results reveal that curcumin-activated autophagy could maintain proteostasis in ER leading to attenuation of ER stress and subsequent inhibition of JNK/IRS-1 pathway and improvement of insulin resistance.	Curcumin	24-32	insulin	Homo sapiens	189-196
28338387-0	2017	Comparison of the Effects of Curcumin and RG108 on NGF-Induced PC-12 Adh Cell Differentiation and Neurite Outgrowth.	Curcumin	29-37	nerve growth factor	Homo sapiens	51-54
28978008-7	2017	Furthermore, inhibition of NFkappaB with its inhibitors (curcumin or Bay) significantly reduced the expression of uPAR and cell migration in the CFTR-overexpressing ISK cells.	Curcumin	57-65	nuclear factor kappa B subunit 1	Homo sapiens	27-35
28978008-7	2017	Furthermore, inhibition of NFkappaB with its inhibitors (curcumin or Bay) significantly reduced the expression of uPAR and cell migration in the CFTR-overexpressing ISK cells.	Curcumin	57-65	CF transmembrane conductance regulator	Homo sapiens	145-149
28259223-7	2017	RESULTS: There was a significant decline in the CRP level (p &lt; 0.05) in rats treated with 200 mg and 400 mg of Curcumin/kg body weight.	Curcumin	114-122	C-reactive protein	Rattus norvegicus	48-51
28320533-0	2017	Retraction notice to "Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity " [JNB 24 (2013) 14-24].	Curcumin	22-30	NFE2 like bZIP transcription factor 2	Homo sapiens	40-44
28138706-0	2017	Curcumin inhibits hypoxia-induced proliferation and invasion of MG-63 osteosarcoma cells via downregulating Notch1.	Curcumin	0-8	notch receptor 1	Homo sapiens	108-114
28138706-6	2017	Further investigation revealed that curcumin may inhibit Notch1 upregulation induced by hypoxia.	Curcumin	36-44	notch receptor 1	Homo sapiens	57-63
28138706-7	2017	Overexpression of Notch1 via Notch1 cDNA transfection ameliorated curcumin-inhibited MG-63 cell growth under hypoxic conditions.	Curcumin	66-74	notch receptor 1	Homo sapiens	18-24
28138706-7	2017	Overexpression of Notch1 via Notch1 cDNA transfection ameliorated curcumin-inhibited MG-63 cell growth under hypoxic conditions.	Curcumin	66-74	notch receptor 1	Homo sapiens	29-35
28138706-8	2017	Taken together, these data revealed that curcumin may suppress the growth of osteosarcoma cells in hypoxia via inhibiting Notch1 signaling.	Curcumin	41-49	notch receptor 1	Homo sapiens	122-128
28350049-6	2017	We provide evidence that curcumin upregulates the expression of CRABPII, RARbeta and RARgamma in two different TNBC cell lines.	Curcumin	25-33	retinoic acid receptor beta	Homo sapiens	73-80
28350049-7	2017	Co-treatment of the cells with curcumin and RA results in increased apoptosis as demonstrated by elevated cleavage of poly(ADP-ribose) polymerase and cleaved caspase-9.	Curcumin	31-39	poly(ADP-ribose) polymerase 1	Homo sapiens	118-145
28377722-0	2017	Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum.	Curcumin	0-8	insulin	Homo sapiens	36-43
28377722-4	2017	Herein, we tested the hypothesis that curcumin action in ER protein quality control was related to improvement of insulin resistance in human umbilical vein endothelial cells (HUVECs) cultured with saturated fatty acid palmitate.	Curcumin	38-46	insulin	Homo sapiens	114-121
28377722-7	2017	In addition, curcumin supplementation mitigated palmitate-induced insulin resistance, inhibited the UPS, and activated autophagy.	Curcumin	13-21	insulin	Homo sapiens	66-73
28377722-9	2017	Genetic inhibition of autophagy by silencing autophagy protein 5 (Atg5) completely restored total protein ubiquitination and protein aggregation in HUVECs treated with combined curcumin and palmitate.	Curcumin	177-185	autophagy related 5	Homo sapiens	45-64
28377722-9	2017	Genetic inhibition of autophagy by silencing autophagy protein 5 (Atg5) completely restored total protein ubiquitination and protein aggregation in HUVECs treated with combined curcumin and palmitate.	Curcumin	177-185	autophagy related 5	Homo sapiens	66-70
28377722-10	2017	Atg5-knockdown also abolished the beneficial effects of curcumin on palmitate-induced ER stress, JNK/IRS-1 pathway as well as insulin signaling.	Curcumin	56-64	autophagy related 5	Homo sapiens	0-4
28377722-10	2017	Atg5-knockdown also abolished the beneficial effects of curcumin on palmitate-induced ER stress, JNK/IRS-1 pathway as well as insulin signaling.	Curcumin	56-64	mitogen-activated protein kinase 8	Homo sapiens	97-100
28293546-1	2017	In rats with induced diabetes, Zinc and curcumin treatment showed a significant increase of catalase and a significant decrease of glucose, lipid profile components and arylsulphatases activity compared to the untreated rats.	Curcumin	40-48	catalase	Rattus norvegicus	92-100
28377722-11	2017	Our results reveal that curcumin-activated autophagy could maintain proteostasis in ER leading to attenuation of ER stress and subsequent inhibition of JNK/IRS-1 pathway and improvement of insulin resistance.	Curcumin	24-32	mitogen-activated protein kinase 8	Homo sapiens	152-155
27569739-1	2017	Curcumin and its derivatives have attracted great interest in the prevention and treatment of Alzheimer"s disease, thanks both to the ability to hinder the formation of amyloid-beta (Abeta) aggregates and the ability to bind Cu (II) ion.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	169-181
28198625-4	2017	According to the histopathological examination of liver tissues and biomarker detection in serum and livers, it was demonstrated that curcumin attenuated DEN-induced hepatocarcinogenesis through parts of regulating the oxidant stress enzymes (T-SOD and CAT), liver function (ALT and AST) and LDHA, AFP level, and COX-2/PGE2 pathway.	Curcumin	134-142	catalase	Mus musculus	243-256
28198625-4	2017	According to the histopathological examination of liver tissues and biomarker detection in serum and livers, it was demonstrated that curcumin attenuated DEN-induced hepatocarcinogenesis through parts of regulating the oxidant stress enzymes (T-SOD and CAT), liver function (ALT and AST) and LDHA, AFP level, and COX-2/PGE2 pathway.	Curcumin	134-142	transmembrane protease, serine 11d	Mus musculus	283-286
28198625-5	2017	Furthermore, curcumin attenuated metabolic disorders via increasing concentration of glucose and fructose, and decreasing levels of glycine and proline, and mRNA expression of GLUT1, PKM and FASN.	Curcumin	13-21	fatty acid synthase	Mus musculus	191-195
28198625-6	2017	Docking study indicated that curcumin presented strong affinity with key metabolism enzymes such as GLUT1, PKM, FASN and LDHA.	Curcumin	29-37	fatty acid synthase	Mus musculus	112-116
27569739-1	2017	Curcumin and its derivatives have attracted great interest in the prevention and treatment of Alzheimer"s disease, thanks both to the ability to hinder the formation of amyloid-beta (Abeta) aggregates and the ability to bind Cu (II) ion.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	183-188
28199187-8	2017	Interestingly, the combined treatment with curcumin and docetaxel modulates the expression of RTKs, PI3K, phospho-AKT, NF-kappa B, p53, and COX-2.	Curcumin	43-51	AKT serine/threonine kinase 1	Homo sapiens	114-117
28175963-0	2017	Curcumin suppresses cisplatin resistance development partly via modulating extracellular vesicle-mediated transfer of MEG3 and miR-214 in ovarian cancer.	Curcumin	0-8	microRNA 214	Homo sapiens	127-134
28175963-9	2017	MEG3 restoration by curcumin significantly reduced miR-214 in cells and in EVs.	Curcumin	20-28	microRNA 214	Homo sapiens	51-58
28199187-8	2017	Interestingly, the combined treatment with curcumin and docetaxel modulates the expression of RTKs, PI3K, phospho-AKT, NF-kappa B, p53, and COX-2.	Curcumin	43-51	tumor protein p53	Homo sapiens	131-134
28199187-8	2017	Interestingly, the combined treatment with curcumin and docetaxel modulates the expression of RTKs, PI3K, phospho-AKT, NF-kappa B, p53, and COX-2.	Curcumin	43-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
28110063-0	2017	Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-kappaB translocation.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	111-120
28110063-6	2017	In addition, curcumin treatment markedly reduced the hepatic protein expression of oxidative stress, pro-inflammatory cytokines, and chemokines including interferon (IFN) gamma, interleukin-1beta and IFNgamma-inducible protein 10, in NASH mice.	Curcumin	13-21	interferon gamma	Mus musculus	154-176
28110063-6	2017	In addition, curcumin treatment markedly reduced the hepatic protein expression of oxidative stress, pro-inflammatory cytokines, and chemokines including interferon (IFN) gamma, interleukin-1beta and IFNgamma-inducible protein 10, in NASH mice.	Curcumin	13-21	interleukin 1 beta	Mus musculus	178-195
28110063-7	2017	Furthermore, curcumin treatment significantly reduced the cytoplasmic translocation of high mobility group box 1 (HMGB1) and the protein expression of toll like receptor 4.	Curcumin	13-21	toll-like receptor 4	Mus musculus	151-171
28110063-8	2017	Nuclear translocation of nuclear factor kappa B (NF-kappaB) was also dramatically attenuated by the curcumin in NASH liver.	Curcumin	100-108	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	25-47
28110063-8	2017	Nuclear translocation of nuclear factor kappa B (NF-kappaB) was also dramatically attenuated by the curcumin in NASH liver.	Curcumin	100-108	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-58
28110063-9	2017	Curcumin treatment effectively reduced the progression of NASH to HCC by suppressing the protein expression of glypican-3, vascular endothelial growth factor, and prothrombin in the NASH liver.	Curcumin	0-8	glypican 3	Mus musculus	111-121
28124574-9	2017	The results showed that curcumin ameliorated the defective insulin signalling pathway by upregulating insulin-like growth factor (IGF)-1R, IRS-2, PI3K, p-PI3K, Akt and p-Akt protein expression while downregulating IR and IRS-1.	Curcumin	24-32	insulin-like growth factor I receptor	Mus musculus	102-137
28124574-9	2017	The results showed that curcumin ameliorated the defective insulin signalling pathway by upregulating insulin-like growth factor (IGF)-1R, IRS-2, PI3K, p-PI3K, Akt and p-Akt protein expression while downregulating IR and IRS-1.	Curcumin	24-32	thymoma viral proto-oncogene 1	Mus musculus	160-163
28110063-10	2017	Our data suggest that curcumin reduces the progression of NASH and liver damage, which may act via inhibiting HMGB1-NF-kappaB translocation.	Curcumin	22-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	116-125
28124574-9	2017	The results showed that curcumin ameliorated the defective insulin signalling pathway by upregulating insulin-like growth factor (IGF)-1R, IRS-2, PI3K, p-PI3K, Akt and p-Akt protein expression while downregulating IR and IRS-1.	Curcumin	24-32	thymoma viral proto-oncogene 1	Mus musculus	170-173
27996348-5	2017	Compared with FZD alone group, curcumin pretreatment significantly reduced the expression of phospho (p)-p38, cyclin D1, p-checkpoint kinase 1 (ChK1) and breast cancer associated gene 1 (BRCA1) protein, followed to attenuate S phase arrest.	Curcumin	31-39	checkpoint kinase 1	Homo sapiens	121-142
28196290-2	2017	The aim of the current study was to test antiendotoxemia effect of curcumin on tetrachloride (CCl4 )-induced liver cirrhosis rats, and to elucidate the underlying molecular mechanism.	Curcumin	67-75	C-C motif chemokine ligand 4	Rattus norvegicus	94-98
28196290-4	2017	We found that the administration of curcumin improved the physiological condition pertaining to activity index and temperature, and ameliorated the liver injury in CCl4 -induced cirrhosis rats.	Curcumin	36-44	C-C motif chemokine ligand 4	Rattus norvegicus	164-168
28196290-5	2017	Enzyme-linked immunosorbent assay (ELISA) and real-time quantitative polymerase chain reaction (qRT-PCR) showed that curcumin could reduce c-reaction protein levels and inflammatory cytokine (TNF-alpha, IL-1beta, IL-6, and CINC-1/IL-8) concentrations in peripheral serum and liver tissue.	Curcumin	117-125	tumor necrosis factor	Rattus norvegicus	192-201
28196290-5	2017	Enzyme-linked immunosorbent assay (ELISA) and real-time quantitative polymerase chain reaction (qRT-PCR) showed that curcumin could reduce c-reaction protein levels and inflammatory cytokine (TNF-alpha, IL-1beta, IL-6, and CINC-1/IL-8) concentrations in peripheral serum and liver tissue.	Curcumin	117-125	interleukin 1 beta	Rattus norvegicus	203-211
28196290-5	2017	Enzyme-linked immunosorbent assay (ELISA) and real-time quantitative polymerase chain reaction (qRT-PCR) showed that curcumin could reduce c-reaction protein levels and inflammatory cytokine (TNF-alpha, IL-1beta, IL-6, and CINC-1/IL-8) concentrations in peripheral serum and liver tissue.	Curcumin	117-125	interleukin 6	Rattus norvegicus	213-217
28196290-7	2017	As low-density lipoprotein receptor (LDLR) is the important receptor on the surface of hepatocyte during LPS detoxification process, we used qRT-PCR, western blot, and immunohistochemistry (IHC), finding that curcumin significantly increased LDLR protein levels, but not gene levels in the liver tissues.	Curcumin	209-217	low density lipoprotein receptor	Rattus norvegicus	3-35
28196290-7	2017	As low-density lipoprotein receptor (LDLR) is the important receptor on the surface of hepatocyte during LPS detoxification process, we used qRT-PCR, western blot, and immunohistochemistry (IHC), finding that curcumin significantly increased LDLR protein levels, but not gene levels in the liver tissues.	Curcumin	209-217	low density lipoprotein receptor	Rattus norvegicus	37-41
28196290-10	2017	Thus, we concluded that curcumin could function to protect against intestinal origin endotoxemia by inhibiting PCSK9 to promote LDLR expression, thereby enhancing LPS detoxification as one pathogen lipid through LDLR in the liver.	Curcumin	24-32	low density lipoprotein receptor	Rattus norvegicus	128-132
28196290-10	2017	Thus, we concluded that curcumin could function to protect against intestinal origin endotoxemia by inhibiting PCSK9 to promote LDLR expression, thereby enhancing LPS detoxification as one pathogen lipid through LDLR in the liver.	Curcumin	24-32	low density lipoprotein receptor	Rattus norvegicus	212-216
28649069-0	2017	Altered antibacterial activity of Curcumin in the presence of serum albumin, plasma and whole blood.	Curcumin	34-42	albumin	Homo sapiens	62-75
28649069-2	2017	This work evaluated the effect of serum albumin, human plasma, and whole blood on the in vitro activity of Curcumin against eight clinical bacterial isolates by standard broth microdilution and plate-counting methods.	Curcumin	107-115	albumin	Homo sapiens	34-47
27935709-6	2017	The incorporation of curcumin into oil-in-water emulsions (30% MCT, 1 mg curcumin/g MCT, d32   298 nm) improved its water dispersibility and chemical stability.	Curcumin	21-29	solute carrier family 16 member 1	Homo sapiens	63-69
27935709-6	2017	The incorporation of curcumin into oil-in-water emulsions (30% MCT, 1 mg curcumin/g MCT, d32   298 nm) improved its water dispersibility and chemical stability.	Curcumin	73-81	solute carrier family 16 member 1	Homo sapiens	63-69
27677346-0	2017	Curcumin synergistically increases effects of beta-interferon and retinoic acid on breast cancer cells in vitro and in vivo by up-regulation of GRIM-19 through STAT3-dependent and STAT3-independent pathways.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	160-165
27677346-0	2017	Curcumin synergistically increases effects of beta-interferon and retinoic acid on breast cancer cells in vitro and in vivo by up-regulation of GRIM-19 through STAT3-dependent and STAT3-independent pathways.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	180-185
27677346-1	2017	OBJECTIVE: The study aimed to investigate the effects of combination treatment of curcumin and beta-interferon (IFN-beta)/retinoic acid (RA) on breast cancer cells, including cell viability, apoptosis and migration, and to determine the mechanisms related to GRIM-19 through STAT3-dependent and STAT3-independent pathways.	Curcumin	82-90	signal transducer and activator of transcription 3	Homo sapiens	275-280
27677346-1	2017	OBJECTIVE: The study aimed to investigate the effects of combination treatment of curcumin and beta-interferon (IFN-beta)/retinoic acid (RA) on breast cancer cells, including cell viability, apoptosis and migration, and to determine the mechanisms related to GRIM-19 through STAT3-dependent and STAT3-independent pathways.	Curcumin	82-90	signal transducer and activator of transcription 3	Homo sapiens	295-300
27677346-8	2017	In addition, curcumin and IFN-beta/RA combination inhibited the expression of COX-2 and up-regulated GADD153.	Curcumin	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-83
27677346-8	2017	In addition, curcumin and IFN-beta/RA combination inhibited the expression of COX-2 and up-regulated GADD153.	Curcumin	13-21	DNA damage inducible transcript 3	Homo sapiens	101-108
26826259-9	2017	Combining glutamine, arginine, and curcumin at optimal concentrations completely abolished the IL-8 response.	Curcumin	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
28076319-7	2017	Conversely, bioactive food components, including curcumin, have been shown to alter epigenetic markers that suppress the activation of NF-kappaB, thus reducing inflammatory responses.	Curcumin	49-57	nuclear factor kappa B subunit 1	Homo sapiens	135-144
27996348-3	2017	The current study aimed to investigate the potential roles of endoplasmic reticulum (ER) stress, p38 mitogen-activated protein kinases (p38 MAPK) signaling pathway in curcumin against FZD cytotoxicity by using human hepatocyte L02 cells.	Curcumin	167-175	mitogen-activated protein kinase 14	Homo sapiens	97-100
27996348-3	2017	The current study aimed to investigate the potential roles of endoplasmic reticulum (ER) stress, p38 mitogen-activated protein kinases (p38 MAPK) signaling pathway in curcumin against FZD cytotoxicity by using human hepatocyte L02 cells.	Curcumin	167-175	mitogen-activated protein kinase 14	Homo sapiens	136-139
27996348-5	2017	Compared with FZD alone group, curcumin pretreatment significantly reduced the expression of phospho (p)-p38, cyclin D1, p-checkpoint kinase 1 (ChK1) and breast cancer associated gene 1 (BRCA1) protein, followed to attenuate S phase arrest.	Curcumin	31-39	mitogen-activated protein kinase 14	Homo sapiens	105-108
27996348-5	2017	Compared with FZD alone group, curcumin pretreatment significantly reduced the expression of phospho (p)-p38, cyclin D1, p-checkpoint kinase 1 (ChK1) and breast cancer associated gene 1 (BRCA1) protein, followed to attenuate S phase arrest.	Curcumin	31-39	checkpoint kinase 1	Homo sapiens	144-148
27996348-6	2017	Meanwhile, curcumin pretreatment prevented FZD induced ER stress, evidenced by the inhibition of glucose-regulated protein 78 and DNA damage inducible gene 153/C/EBP-homologous protein (GADD153/CHOP) protein expression.	Curcumin	11-19	DNA damage inducible transcript 3	Homo sapiens	186-193
27996348-6	2017	Meanwhile, curcumin pretreatment prevented FZD induced ER stress, evidenced by the inhibition of glucose-regulated protein 78 and DNA damage inducible gene 153/C/EBP-homologous protein (GADD153/CHOP) protein expression.	Curcumin	11-19	DNA damage inducible transcript 3	Homo sapiens	194-198
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	20-28	solute carrier organic anion transporter family member 1B3	Homo sapiens	251-258
27996348-7	2017	Moreover, compared with the control, FZD exposure activated the protein and mRNA expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1), which were further activated by curcumin treatment.	Curcumin	214-222	NFE2 like bZIP transcription factor 2	Homo sapiens	102-145
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	214-222	solute carrier organic anion transporter family member 1B3	Homo sapiens	321-328
27996348-7	2017	Moreover, compared with the control, FZD exposure activated the protein and mRNA expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1), which were further activated by curcumin treatment.	Curcumin	214-222	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
27174018-8	2017	Inhibition study using rosuvastatin as the substrate in OATP1B1- and OATP1B3-transfected cells indicated that curcumin was an OATP1B1 and 1B3 inhibitor, with IC50 at 5.19 +- 0.05 and 3.68 +- 0.05 muM, respectively; the data for COG were 1.04 +- 0.01 and 1.08 +- 0.02 muM, respectively.	Curcumin	110-118	solute carrier organic anion transporter family member 1B3	Homo sapiens	69-76
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	20-28	solute carrier organic anion transporter family member 1B3	Homo sapiens	321-328
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	214-222	solute carrier organic anion transporter family member 1B3	Homo sapiens	251-258
27996348-8	2017	These results reveal that curcumin could prevent FZD induced cytotoxicity and S phase arrest, which may involve the activation of Nrf2/HO-1 pathway and the inhibition of p38 MAPK pathway and ER stress.	Curcumin	26-34	NFE2 like bZIP transcription factor 2	Homo sapiens	130-134
27996348-8	2017	These results reveal that curcumin could prevent FZD induced cytotoxicity and S phase arrest, which may involve the activation of Nrf2/HO-1 pathway and the inhibition of p38 MAPK pathway and ER stress.	Curcumin	26-34	mitogen-activated protein kinase 14	Homo sapiens	170-173
30920505-4	2017	The in vitro release of curcumin from the -NH2 and CMC functionalized MSNs (MSN-cur-NH2 and MSN-cur-CMC) was performed in 0.5% aqueous solution of sodium lauryl sulphate (SLS).	Curcumin	24-32	moesin	Homo sapiens	70-73
28231299-5	2017	Therefore, we suggest miR-34a-5p/miR-34c-5p/miR-302b-3p -LEF1-CCND1/WNT1/MYC axis may be a crucial mechanism in inhibition of lung cancer metastasis by curcumin.	Curcumin	152-160	Wnt family member 1	Homo sapiens	68-72
30920505-4	2017	The in vitro release of curcumin from the -NH2 and CMC functionalized MSNs (MSN-cur-NH2 and MSN-cur-CMC) was performed in 0.5% aqueous solution of sodium lauryl sulphate (SLS).	Curcumin	24-32	moesin	Homo sapiens	76-79
30920505-7	2017	The MTT assay study revealed that curcumin-loaded MSN-cur-CMC showed better uptake as compared to curcumin-loaded MSN-cur-NH2.	Curcumin	34-42	moesin	Homo sapiens	50-53
30920505-7	2017	The MTT assay study revealed that curcumin-loaded MSN-cur-CMC showed better uptake as compared to curcumin-loaded MSN-cur-NH2.	Curcumin	98-106	moesin	Homo sapiens	114-117
28297801-14	2017	Curcumin can reduce such damage, and its mechanism of action may be related to up-regulating the expression of occludin in the intestinal mucosa and reducing the levels of TNFalpha and LPS.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	172-180
28261097-0	2017	Curcumin Alleviates oxLDL Induced MMP-9 and EMMPRIN Expression through the Inhibition of NF-kappaB and MAPK Pathways in Macrophages.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	89-98
28337260-0	2017	miR-590-3p mediates the protective effect of curcumin on injured endothelial cells induced by angiotensin II.	Curcumin	45-53	microRNA 590	Homo sapiens	0-7
28337260-0	2017	miR-590-3p mediates the protective effect of curcumin on injured endothelial cells induced by angiotensin II.	Curcumin	45-53	angiotensinogen	Homo sapiens	94-108
28261097-9	2017	Further studies revealed that curcumin inhibited oxLDL induced NF-kappaB activation and p38 MAPK phosphorylation.	Curcumin	30-38	nuclear factor kappa B subunit 1	Homo sapiens	63-72
28261097-9	2017	Further studies revealed that curcumin inhibited oxLDL induced NF-kappaB activation and p38 MAPK phosphorylation.	Curcumin	30-38	mitogen-activated protein kinase 14	Homo sapiens	88-91
28261097-10	2017	These findings illustrated that curcumin can inhibit the expression of EMMPRIN and MMP-9 in oxLDL stimulated macrophages through down regulation of NF-kappaB and p38 MAPK signaling pathways, which might be the molecular mechanism for the anti-atherosclerotic effect of curcumin.	Curcumin	32-40	nuclear factor kappa B subunit 1	Homo sapiens	148-157
28261097-10	2017	These findings illustrated that curcumin can inhibit the expression of EMMPRIN and MMP-9 in oxLDL stimulated macrophages through down regulation of NF-kappaB and p38 MAPK signaling pathways, which might be the molecular mechanism for the anti-atherosclerotic effect of curcumin.	Curcumin	32-40	mitogen-activated protein kinase 14	Homo sapiens	162-165
28160777-13	2017	Curcumin induced ROS, promoted MAPK pathway activation, downregulated STAT3 activity and IAP family members.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	70-75
28120490-0	2017	Curcumin inhibits the survival and metastasis of prostate cancer cells via the Notch-1 signaling pathway.	Curcumin	0-8	notch receptor 1	Homo sapiens	79-86
28120490-9	2017	In conclusion, curcumin inhibited the survival and metastasis of prostate cancer cells via the Notch-1 signaling pathway.	Curcumin	15-23	notch receptor 1	Homo sapiens	95-102
28179291-8	2017	Expression of FGF2, MMP2, VEGF, HGF, TF and FVII was reduced by AS-IV and curcumin alone.	Curcumin	74-82	fibroblast growth factor 2	Homo sapiens	14-18
28179291-8	2017	Expression of FGF2, MMP2, VEGF, HGF, TF and FVII was reduced by AS-IV and curcumin alone.	Curcumin	74-82	vascular endothelial growth factor A	Homo sapiens	26-30
28143589-3	2017	This study was performed to evaluate the hepatoprotective activity of CLL extract and its active component curcumin in an acute carbon tetrachloride (CCl4)-induced liver stress model.	Curcumin	107-115	C-C motif chemokine ligand 4	Rattus norvegicus	150-154
28237485-1	2017	OBJECTIVE: To observe the effect of curcumin on expressions of nuclear transcription factor-kappa Bp65 (NF-kappaBp65), TNF-alpha and IL-8 in placental tissue of premature birth of infected mice induced by lipopolysaccharide (LPS).	Curcumin	36-44	tumor necrosis factor	Mus musculus	119-128
28237485-10	2017	CONCLUSIONS: Curcumin can effectively prevent the active pathway of NF-kappaB in pregnant tissue of premature birth of infected mice, reduce the expression of TNF-alpha and IL-8 and relieve the damage of lipid peroxide of oxidative stress of LPS on mother-fetus and further to achieve the objective of preventing and curing premature birth induced with infection.	Curcumin	13-21	tumor necrosis factor	Mus musculus	159-168
28143589-12	2017	We found that CLL extract and curcumin exhibited significant protection against liver injury by improving hepatic superoxide dismutase (p &lt; 0.05) and glutathione peroxidase activity, and glutathione content in the CCl4-treated group (p &lt; 0.05), leading to a reduced lipid peroxidase level.	Curcumin	30-38	C-C motif chemokine ligand 4	Rattus norvegicus	217-221
28143589-13	2017	CONCLUSION: Our data suggested that CLL extract and curcumin protect the liver from acute CCl4-induced injury in a rodent model by suppressing hepatic oxidative stress.	Curcumin	52-60	C-C motif chemokine ligand 4	Rattus norvegicus	90-94
28272691-14	2017	In curcumin-treated rats, the expression of Bcl-2 and Survivin were significantly decreased while Bax protein expression was significantly elevated (p &lt; 0.05).	Curcumin	3-11	BCL2, apoptosis regulator	Rattus norvegicus	44-49
27901349-0	2017	Curcumin improves the metabolic syndrome in high-fructose-diet-fed rats: role of TNF-alpha, NF-kappaB, and oxidative stress.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	81-90
27967217-4	2017	Using peroxisome proliferator-activated receptor alpha (PPARalpha) agonist and antagonist, along with luciferase reporter and chromatin immune-precipitation approaches, we determined that curcumin stimulates Fgf21 transcription in a mechanism involving PPARalpha activation.	Curcumin	188-196	peroxisome proliferator activated receptor alpha	Mus musculus	6-54
27967217-4	2017	Using peroxisome proliferator-activated receptor alpha (PPARalpha) agonist and antagonist, along with luciferase reporter and chromatin immune-precipitation approaches, we determined that curcumin stimulates Fgf21 transcription in a mechanism involving PPARalpha activation.	Curcumin	188-196	peroxisome proliferator activated receptor alpha	Mus musculus	56-65
27967217-4	2017	Using peroxisome proliferator-activated receptor alpha (PPARalpha) agonist and antagonist, along with luciferase reporter and chromatin immune-precipitation approaches, we determined that curcumin stimulates Fgf21 transcription in a mechanism involving PPARalpha activation.	Curcumin	188-196	peroxisome proliferator activated receptor alpha	Mus musculus	253-262
27817102-0	2017	Curcumin inhibits placental inflammation to ameliorate LPS-induced adverse pregnancy outcomes in mice via upregulation of phosphorylated Akt.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	137-140
27817102-8	2017	Moreover, increased placental TNF-alpha, IL-1beta, and IL-6 expressions in LPS-treated group were significantly suppressed after curcumin administration.	Curcumin	129-137	tumor necrosis factor	Mus musculus	30-39
27866296-0	2017	Intranasal Curcumin Inhibits Pulmonary Fibrosis by Modulating Matrix Metalloproteinase-9 (MMP-9) in Ovalbumin-Induced Chronic Asthma.	Curcumin	11-19	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	100-109
27866296-6	2017	Intranasal administration of curcumin significantly inhibited airway inflammation and pulmonary fibrosis, where MMP-9 activities were decreased along with alpha-smooth muscle actin (alpha-SMA), MMP-9, TIMP-1, and eotaxin expressions.	Curcumin	29-37	actin alpha 2, smooth muscle, aorta	Mus musculus	155-180
27817102-8	2017	Moreover, increased placental TNF-alpha, IL-1beta, and IL-6 expressions in LPS-treated group were significantly suppressed after curcumin administration.	Curcumin	129-137	interleukin 1 beta	Mus musculus	41-49
27866296-6	2017	Intranasal administration of curcumin significantly inhibited airway inflammation and pulmonary fibrosis, where MMP-9 activities were decreased along with alpha-smooth muscle actin (alpha-SMA), MMP-9, TIMP-1, and eotaxin expressions.	Curcumin	29-37	actin alpha 2, smooth muscle, aorta	Mus musculus	182-191
27866296-6	2017	Intranasal administration of curcumin significantly inhibited airway inflammation and pulmonary fibrosis, where MMP-9 activities were decreased along with alpha-smooth muscle actin (alpha-SMA), MMP-9, TIMP-1, and eotaxin expressions.	Curcumin	29-37	tissue inhibitor of metalloproteinase 1	Mus musculus	201-207
27817102-8	2017	Moreover, increased placental TNF-alpha, IL-1beta, and IL-6 expressions in LPS-treated group were significantly suppressed after curcumin administration.	Curcumin	129-137	interleukin 6	Mus musculus	55-59
27866296-6	2017	Intranasal administration of curcumin significantly inhibited airway inflammation and pulmonary fibrosis, where MMP-9 activities were decreased along with alpha-smooth muscle actin (alpha-SMA), MMP-9, TIMP-1, and eotaxin expressions.	Curcumin	29-37	chemokine (C-C motif) ligand 11	Mus musculus	213-220
27817102-9	2017	Furthermore, decreased p-Akt level in placenta induced by LPS was improved by curcumin.	Curcumin	78-86	thymoma viral proto-oncogene 1	Mus musculus	25-28
27817102-10	2017	Of note, the expression of p-Akt increased by curcumin was accompanied by the decreased chemokines MCP-1 and MIP-1 levels and fewer CD68-positive macrophages in the placenta.	Curcumin	46-54	thymoma viral proto-oncogene 1	Mus musculus	29-32
27817102-10	2017	Of note, the expression of p-Akt increased by curcumin was accompanied by the decreased chemokines MCP-1 and MIP-1 levels and fewer CD68-positive macrophages in the placenta.	Curcumin	46-54	mast cell protease 1	Mus musculus	99-104
27817102-11	2017	CONCLUSION: Curcumin inhibited the expression of proinflammatory factors and macrophage infiltration in placenta and ameliorated LPS-induced adverse pregnancy outcomes in mice by inhibiting inflammation via upregulation of phosphorylated Akt.	Curcumin	12-20	thymoma viral proto-oncogene 1	Mus musculus	238-241
28146408-9	2017	Curcumin treatment (therapeutic) caused a significant decrease (by 6.0- and 2.0-fold, respectively) in serum TNF-alpha and IFN-gamma level, while IL-10 and IL-4 were elevated (by 1.4- and 1.8-fold).	Curcumin	0-8	tumor necrosis factor	Mus musculus	109-118
28146408-9	2017	Curcumin treatment (therapeutic) caused a significant decrease (by 6.0- and 2.0-fold, respectively) in serum TNF-alpha and IFN-gamma level, while IL-10 and IL-4 were elevated (by 1.4- and 1.8-fold).	Curcumin	0-8	interferon gamma	Mus musculus	123-132
28075466-0	2017	Co-delivery of doxorubicin and pH-sensitive curcumin prodrug by transferrin-targeted nanoparticles for breast cancer treatment.	Curcumin	44-52	transferrin	Homo sapiens	64-75
28197150-6	2017	Our results show that curcumin induced a higher percentage of M2 macrophages together with a higher concentration of anti-inflammatory cytokine IL-10, and a lower percentage of M1 macrophages with a lower concentration of pro-inflammatory cytokines (TNF-alpha and IL-6).	Curcumin	22-30	interleukin 10	Mus musculus	144-149
28063511-8	2017	The reports from preclinical and clinical findings revealed that curcumin can reverse insulin resistance, hyperglycemia, obesity, and obesity-related metabolic diseases.	Curcumin	65-73	insulin	Homo sapiens	86-93
28197150-6	2017	Our results show that curcumin induced a higher percentage of M2 macrophages together with a higher concentration of anti-inflammatory cytokine IL-10, and a lower percentage of M1 macrophages with a lower concentration of pro-inflammatory cytokines (TNF-alpha and IL-6).	Curcumin	22-30	tumor necrosis factor	Mus musculus	250-259
28197150-6	2017	Our results show that curcumin induced a higher percentage of M2 macrophages together with a higher concentration of anti-inflammatory cytokine IL-10, and a lower percentage of M1 macrophages with a lower concentration of pro-inflammatory cytokines (TNF-alpha and IL-6).	Curcumin	22-30	interleukin 6	Mus musculus	264-268
28197150-7	2017	The genes encoding CD86 (M1) and CD163 (M2), two additional markers, were shifted by curcumin toward an M2 phenotype.	Curcumin	85-93	CD86 antigen	Mus musculus	19-23
28197150-7	2017	The genes encoding CD86 (M1) and CD163 (M2), two additional markers, were shifted by curcumin toward an M2 phenotype.	Curcumin	85-93	CD163 antigen	Mus musculus	33-38
27829579-0	2017	Curcumin Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells through the Inhibition of Akt/mTOR Pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	114-117
28120887-7	2017	Conversely, treatment of cells with curcumin, a drug disrupting ceramide and Ca2+ homeostasis in the ER, stabilizes SMSr oligomers and promotes retention of the enzyme in the ER.	Curcumin	36-44	sterile alpha motif domain containing 8	Homo sapiens	116-120
28002947-0	2017	A Carbocyclic Curcumin Inhibits Proliferation of Gram-Positive Bacteria by Targeting FtsZ.	Curcumin	14-22	cell-division initiation protein	Bacillus subtilis subsp. subtilis str. 168	85-89
28002947-2	2017	Here, we report the identification of a potent carbocyclic curcumin analogue (2d) that inhibits Bacillus subtilis 168 cell proliferation by targeting the assembly of FtsZ.	Curcumin	59-67	cell-division initiation protein	Bacillus subtilis subsp. subtilis str. 168	166-170
28002947-11	2017	The results together suggested that the non-natural curcumin analogue 2d possesses powerful antibacterial activity against important pathogenic bacteria, and the evidence indicates that 2d inhibits bacterial proliferation by targeting FtsZ.	Curcumin	52-60	cell-division initiation protein	Bacillus subtilis subsp. subtilis str. 168	235-239
28056970-6	2017	In vitro experiments demonstrated that curcumin treatment could reverse the up-regulation of active forms of caspase-3 and caspase-8, and down-regulation of bcl-2 induced by alcohol treatment.	Curcumin	39-47	caspase 3	Homo sapiens	109-118
28056970-6	2017	In vitro experiments demonstrated that curcumin treatment could reverse the up-regulation of active forms of caspase-3 and caspase-8, and down-regulation of bcl-2 induced by alcohol treatment.	Curcumin	39-47	BCL2 apoptosis regulator	Homo sapiens	157-162
27604683-0	2017	Antiproliferative and Apoptotic Effect of Dendrosomal Curcumin Nanoformulation in P53 Mutant and Wide-Type Cancer Cell Lines.	Curcumin	54-62	tumor protein p53	Homo sapiens	82-85
28240011-3	2017	Curcumin was used at concentrations of 5, 15, 30 and 50 muM.	Curcumin	0-8	latexin	Homo sapiens	56-59
28240011-7	2017	Combination with curcumin(15-50 mum) significantly increased cytotoxicity of all three agents (P&lt;0.001).	Curcumin	17-25	latexin	Homo sapiens	32-35
27894665-10	2017	The present results suggest that curcumin supplementation increases cytotoxicity-related molecules granzyme A and granulysin in patients with HAM/TSP.	Curcumin	33-41	thrombospondin 1	Homo sapiens	146-149
28194406-7	2017	Additionally, curcumin treatment was associated with significant reductions in mature interleukin-1beta, cleaved caspase-1, and NLRP3 protein levels in the renal cortices of db/db mice as well as in HK-2 cells exposed to high glucose concentration.	Curcumin	14-22	interleukin 1 beta	Mus musculus	86-103
28291961-0	2017	Attenuation of Oxidative Stress-Induced Osteoblast Apoptosis by Curcumin is Associated with Preservation of Mitochondrial Functions and Increased Akt-GSK3beta Signaling.	Curcumin	64-72	AKT serine/threonine kinase 1	Homo sapiens	146-149
28291961-13	2017	Furthermore, curcumin treatment markedly increased levels of phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3beta (GSK3beta).	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	94-97
28291961-14	2017	CONCLUSION: Curcumin administration ameliorates oxidative stress-induced apoptosis in osteoblasts by preserving mitochondrial functions and activation of Akt-GSK3beta signaling.	Curcumin	12-20	AKT serine/threonine kinase 1	Homo sapiens	154-157
28000447-6	2017	Moreover, curcumin supplementation down-regulated the mRNA and protein expressions of sterol regulatory element binding protein-2 (SREBP-2) and NPC1L1 in the small intestine (P &lt; 0.05).	Curcumin	10-18	sterol regulatory element binding transcription factor 2	Homo sapiens	86-129
28000447-6	2017	Moreover, curcumin supplementation down-regulated the mRNA and protein expressions of sterol regulatory element binding protein-2 (SREBP-2) and NPC1L1 in the small intestine (P &lt; 0.05).	Curcumin	10-18	sterol regulatory element binding transcription factor 2	Homo sapiens	131-138
28000447-7	2017	Our current results indicate that curcumin inhibits cholesterol absorption in hamsters by suppressing SREBP-2 and subsequently down-regulating NPC1L1 expression, which may be responsible for the hypocholesterolemic effects of curcumin.	Curcumin	34-42	sterol regulatory element binding transcription factor 2	Homo sapiens	102-109
28071969-3	2017	In the present study, we demonstrated that curcumin induced G2/M cell cycle arrest and apoptosis by increasing the expression levels of cleaved caspase-3, cleaved PARP and decreasing the expression of BCL-2 in U937 human leukemic cells but not in K562 cells.	Curcumin	43-51	BCL2 apoptosis regulator	Homo sapiens	201-206
28071969-5	2017	In addition, inhibiting the expression of IFIT2 by shRNA in U937 rescued curcumin-induced apoptosis and exogenous overexpression of IFIT2 by lentiviral transduction or treating with IFNgamma in K562 cells enhanced anti-cancer activity of curcumin.	Curcumin	73-81	interferon gamma	Homo sapiens	182-190
28071969-5	2017	In addition, inhibiting the expression of IFIT2 by shRNA in U937 rescued curcumin-induced apoptosis and exogenous overexpression of IFIT2 by lentiviral transduction or treating with IFNgamma in K562 cells enhanced anti-cancer activity of curcumin.	Curcumin	238-246	interferon gamma	Homo sapiens	182-190
28249909-6	2017	Data mining of the National Library of Medicine"s MEDLINE Database and Ingenuity Pathway analysis revealed agents of relatively low toxicity-melatonin, metformin, curcumin and sulforaphane-that are capable of inhibiting directly or pharmacogenomically one or both of the SIRT1 and EZH2 pathways and should, in a combinatorial fashion, remove the block in differentiation and decrease the proliferation of the B-cell ALL lymphoblasts.	Curcumin	163-171	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	281-285
28691015-0	2017	"mTOR Signaling Pathway": A Potential Target of Curcumin in the Treatment of Spinal Cord Injury.	Curcumin	48-56	mechanistic target of rapamycin kinase	Homo sapiens	1-5
28691015-1	2017	The purpose of this review is to discuss the possibility of the treatment of spinal cord injury (SCI) with curcumin via regulating the mTOR signaling pathway, which may provide another strong support for curcumin to be a promising medicine applied to the treatment of SCI.	Curcumin	107-115	mechanistic target of rapamycin kinase	Homo sapiens	135-139
28691015-1	2017	The purpose of this review is to discuss the possibility of the treatment of spinal cord injury (SCI) with curcumin via regulating the mTOR signaling pathway, which may provide another strong support for curcumin to be a promising medicine applied to the treatment of SCI.	Curcumin	204-212	mechanistic target of rapamycin kinase	Homo sapiens	135-139
28691015-2	2017	Curcumin is termed as a multifunctional targeting therapy drug that regulates the mTOR signaling pathway in the treatment of numerous diseases.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	82-86
27771282-5	2017	Western blotting and qPCR identified two inducers of BCRP (quercetin and naringin) and two down-regulators (17-beta-estradiol and curcumin) with associated changes in BCRP efflux transport function further confirmed in both cell lines.	Curcumin	130-138	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	167-171
27771282-7	2017	These findings establish the regulatory role AhR of in controlling BCRP expression at the BBB and confirm quercetin, naringin, 17-beta-estradiol, and curcumin as novel inducers and down-regulators of BCRP gene, protein expression and functional transporter activity and hence potential novel target sites and candidates for enhancing CNS drug delivery.	Curcumin	150-158	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	200-204
28478460-0	2017	Curcumin Inhibits Heat-Induced Apoptosis by Suppressing NADPH Oxidase 2 and Activating the Akt/mTOR Signaling Pathway in Bronchial Epithelial Cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	91-94
28478460-0	2017	Curcumin Inhibits Heat-Induced Apoptosis by Suppressing NADPH Oxidase 2 and Activating the Akt/mTOR Signaling Pathway in Bronchial Epithelial Cells.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	95-99
28478460-13	2017	Downregulation of Akt and mTOR phosphorylation induced by heat was also reversed by curcumin.	Curcumin	84-92	AKT serine/threonine kinase 1	Homo sapiens	18-21
28478460-13	2017	Downregulation of Akt and mTOR phosphorylation induced by heat was also reversed by curcumin.	Curcumin	84-92	mechanistic target of rapamycin kinase	Homo sapiens	26-30
28478460-16	2017	CONCLUSION: This study demonstrates that one of the critical mechanisms underlying curcumin inhibiting heat-induced apoptosis is through suppressing NADPH Oxidase 2 and activating the Akt/mTOR signaling pathway in bronchial epithelial cells.	Curcumin	83-91	AKT serine/threonine kinase 1	Homo sapiens	184-187
28478460-16	2017	CONCLUSION: This study demonstrates that one of the critical mechanisms underlying curcumin inhibiting heat-induced apoptosis is through suppressing NADPH Oxidase 2 and activating the Akt/mTOR signaling pathway in bronchial epithelial cells.	Curcumin	83-91	mechanistic target of rapamycin kinase	Homo sapiens	188-192
27829579-0	2017	Curcumin Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells through the Inhibition of Akt/mTOR Pathway.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	118-122
27829579-2	2017	Therefore, we investigated the anti-fibrosis effects of curcumin in transforming growth factor-beta1 (TGF-beta1)-induced epithelial-to-mesenchymal transition (EMT), and the mechanism by which it mediates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway.	Curcumin	56-64	transforming growth factor beta 1	Homo sapiens	102-111
28934730-0	2017	Dihydroartemisinin and Curcumin Synergistically Induce Apoptosis in SKOV3 Cells Via Upregulation of MiR-124 Targeting Midkine.	Curcumin	23-31	midkine	Homo sapiens	118-125
29145208-0	2017	Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice.	Curcumin	0-8	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	89-92
29145208-4	2017	RESULTS: The number of apoptotic cells in the retina of rd1 mice at postnatal day 14 significantly decreased with curcumin treatment and visual function was improved.	Curcumin	114-122	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	56-59
29145208-7	2017	CONCLUSIONS: Curcumin delayed retinal degeneration by suppressing microglia activation in the retina of rd1 mice.	Curcumin	13-21	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	104-107
29161719-2	2017	Curcumin can attenuate Abeta-induced neurotoxicity through ROS scavenging, but the protective effect of intracellular curcumin on neurocyte membranes against extracellular Abeta may be compromised.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	23-28
29161719-2	2017	Curcumin can attenuate Abeta-induced neurotoxicity through ROS scavenging, but the protective effect of intracellular curcumin on neurocyte membranes against extracellular Abeta may be compromised.	Curcumin	118-126	amyloid beta precursor protein	Homo sapiens	172-177
29161719-12	2017	This curcumin, cultivated on the membranes of neurocytes, may prevent Abeta-mediated ROS production and may inhibit the direct interaction between Abeta and the cellular membrane.	Curcumin	5-13	amyloid beta precursor protein	Homo sapiens	70-75
29161719-12	2017	This curcumin, cultivated on the membranes of neurocytes, may prevent Abeta-mediated ROS production and may inhibit the direct interaction between Abeta and the cellular membrane.	Curcumin	5-13	amyloid beta precursor protein	Homo sapiens	147-152
29161719-13	2017	Furthermore, P-curcumin could scavenge Abeta-mediated ROS as curcumin in vitro and in vivo, and had the potential to prevent lipid peroxidation.	Curcumin	15-23	amyloid beta precursor protein	Homo sapiens	39-44
29161719-15	2017	To examine P-curcumin"s ability to attenuate direct interaction between Abeta and cell membranes, the binding affinity of Abeta to curcumin and P-curcumin was determined.	Curcumin	13-21	amyloid beta precursor protein	Homo sapiens	72-77
29161719-19	2017	CONCLUSION: Cultivated curcumin weakened the direct interaction between Abeta and cell membranes and showed greater neuroprotective effects against Abeta insult than free curcumin.	Curcumin	23-31	amyloid beta precursor protein	Homo sapiens	72-77
29161719-19	2017	CONCLUSION: Cultivated curcumin weakened the direct interaction between Abeta and cell membranes and showed greater neuroprotective effects against Abeta insult than free curcumin.	Curcumin	23-31	amyloid beta precursor protein	Homo sapiens	148-153
27592626-0	2017	Curcumin Suppresses Tumor Growth and Angiogenesis in Human Glioma Cells Through Modulation of Vascular Endothelial Growth Factor/ Angiopoietin-2/Thrombospondin-1 Signaling.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	94-128
27592626-0	2017	Curcumin Suppresses Tumor Growth and Angiogenesis in Human Glioma Cells Through Modulation of Vascular Endothelial Growth Factor/ Angiopoietin-2/Thrombospondin-1 Signaling.	Curcumin	0-8	thrombospondin 1	Homo sapiens	145-161
27592626-8	2017	Expression of VEGF and Ang-2 was inhibited by curcumin, whereas TSP-1 expression was up-regulated.	Curcumin	46-54	vascular endothelial growth factor A	Homo sapiens	14-18
27592626-9	2017	CONCLUSION: This study shows that curcumin inhibits tumor growth by inhibiting VEGF/Ang-2/TSP-1- mediated angiogenesis in a xenograft glioma mouse model.	Curcumin	34-42	thrombospondin 1	Homo sapiens	90-95
29299989-3	2017	Therefore, this analysis was performed to investigate the effect of curcumin on adiponectin, leptin and ghrelin.	Curcumin	68-76	adiponectin, C1Q and collagen domain containing	Homo sapiens	80-91
29299989-9	2017	CONCLUSION: Curcumin supplementation increased adiponectin, whilst the the leptin:adiponectin ratio (a measure of atherosclerosis) and leptin levels were decreased independent of weight change and reflected a decrease in the inflammatory TNF-alpha levels.	Curcumin	12-20	adiponectin, C1Q and collagen domain containing	Homo sapiens	47-58
29299989-9	2017	CONCLUSION: Curcumin supplementation increased adiponectin, whilst the the leptin:adiponectin ratio (a measure of atherosclerosis) and leptin levels were decreased independent of weight change and reflected a decrease in the inflammatory TNF-alpha levels.	Curcumin	12-20	tumor necrosis factor	Homo sapiens	238-247
28228072-7	2017	Specifically, curcumin"s anti-inflammatory effects are thought to be caused by reducing trans-endothelial monocyte migration by reduction of mRNA and protein expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and P-selectin and by modulating NFkappaB, JNK, p38 and STAT-3 in endothelial cells.	Curcumin	14-22	vascular cell adhesion molecule 1	Homo sapiens	207-240
28228072-7	2017	Specifically, curcumin"s anti-inflammatory effects are thought to be caused by reducing trans-endothelial monocyte migration by reduction of mRNA and protein expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and P-selectin and by modulating NFkappaB, JNK, p38 and STAT-3 in endothelial cells.	Curcumin	14-22	nuclear factor kappa B subunit 1	Homo sapiens	274-282
28228072-7	2017	Specifically, curcumin"s anti-inflammatory effects are thought to be caused by reducing trans-endothelial monocyte migration by reduction of mRNA and protein expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and P-selectin and by modulating NFkappaB, JNK, p38 and STAT-3 in endothelial cells.	Curcumin	14-22	mitogen-activated protein kinase 14	Homo sapiens	289-292
28228072-7	2017	Specifically, curcumin"s anti-inflammatory effects are thought to be caused by reducing trans-endothelial monocyte migration by reduction of mRNA and protein expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and P-selectin and by modulating NFkappaB, JNK, p38 and STAT-3 in endothelial cells.	Curcumin	14-22	signal transducer and activator of transcription 3	Homo sapiens	297-303
28203261-4	2017	Here we found that curcumin pretreatment significantly represses TGF-beta1-induced Smad pathway and decreases its downstream alpha-smooth muscle actin (alpha-SMA) gene expression in intestinal epithelial cells (IEC-6); in contrast, curcumin increases expression of E-cadherin and peroxisome proliferator-activated receptor gamma (PPARgamma) in IEC-6.	Curcumin	19-27	transforming growth factor, beta 1	Rattus norvegicus	65-74
28203261-4	2017	Here we found that curcumin pretreatment significantly represses TGF-beta1-induced Smad pathway and decreases its downstream alpha-smooth muscle actin (alpha-SMA) gene expression in intestinal epithelial cells (IEC-6); in contrast, curcumin increases expression of E-cadherin and peroxisome proliferator-activated receptor gamma (PPARgamma) in IEC-6.	Curcumin	232-240	transforming growth factor, beta 1	Rattus norvegicus	65-74
28769986-0	2017	Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway.	Curcumin	0-8	tumor protein p53	Homo sapiens	17-20
28769986-0	2017	Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	73-76
28769986-2	2017	This study explored the mechanism by which curcumin induces p53-null hepatoma cell apoptosis.	Curcumin	43-51	tumor protein p53	Homo sapiens	60-63
28769986-3	2017	RESULTS: AKT, FOXO1, and FOXO3 proteins were downregulated after curcumin treatment.	Curcumin	65-73	AKT serine/threonine kinase 1	Homo sapiens	9-12
28769986-3	2017	RESULTS: AKT, FOXO1, and FOXO3 proteins were downregulated after curcumin treatment.	Curcumin	65-73	forkhead box O1	Homo sapiens	14-19
28769986-3	2017	RESULTS: AKT, FOXO1, and FOXO3 proteins were downregulated after curcumin treatment.	Curcumin	65-73	forkhead box O3	Homo sapiens	25-30
29132129-10	2017	CONCLUSION: The activation of iNOS/NO/cGMP/PKG signaling pathway and the consequent promoted apoptosis of renal tubules are significantly involved in the pathogenesis of development of RIRI, and curcumin treatment could protect renal tubules against RIRI, at least partially, by suppressing the activated iNOS/NO/cGMP/PKG signaling pathway.	Curcumin	195-203	nitric oxide synthase 2	Rattus norvegicus	30-34
29132129-10	2017	CONCLUSION: The activation of iNOS/NO/cGMP/PKG signaling pathway and the consequent promoted apoptosis of renal tubules are significantly involved in the pathogenesis of development of RIRI, and curcumin treatment could protect renal tubules against RIRI, at least partially, by suppressing the activated iNOS/NO/cGMP/PKG signaling pathway.	Curcumin	195-203	nitric oxide synthase 2	Rattus norvegicus	305-309
28117012-0	2017	Current Status and Perspectives Regarding the Therapeutic Potential of Targeting EGFR Pathway by Curcumin in Lung Cancer.	Curcumin	97-105	epidermal growth factor receptor	Homo sapiens	81-85
28203261-7	2017	Collectively, these results indicated that curcumin is able to prevent EMT progress in intestinal fibrosis by PPARgamma-mediated repression of TGF-beta1/Smad pathway.	Curcumin	43-51	transforming growth factor, beta 1	Rattus norvegicus	143-152
29081818-11	2017	Protein expression of Bax and LC3II was upregulated, while Bcl2 was downregulated in the high dosing groups of curcumin.	Curcumin	111-119	BCL2 associated X, apoptosis regulator	Homo sapiens	22-25
29081818-11	2017	Protein expression of Bax and LC3II was upregulated, while Bcl2 was downregulated in the high dosing groups of curcumin.	Curcumin	111-119	BCL2 apoptosis regulator	Homo sapiens	59-63
27829579-7	2017	When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin.	Curcumin	47-55	transforming growth factor beta 1	Homo sapiens	213-222
27829579-7	2017	When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin.	Curcumin	47-55	cadherin 1	Homo sapiens	252-262
27829579-7	2017	When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin.	Curcumin	66-74	transforming growth factor beta 1	Homo sapiens	33-42
27829579-7	2017	When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin.	Curcumin	66-74	transforming growth factor beta 1	Homo sapiens	213-222
27829579-7	2017	When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin.	Curcumin	66-74	cadherin 1	Homo sapiens	252-262
27829579-8	2017	Importantly, we found that curcumin reduced Akt, mTOR and P70S6K phosphorylation, effectively suppressing the activity of the Akt/mTOR pathway in HKCs.	Curcumin	27-35	AKT serine/threonine kinase 1	Homo sapiens	44-47
27829579-8	2017	Importantly, we found that curcumin reduced Akt, mTOR and P70S6K phosphorylation, effectively suppressing the activity of the Akt/mTOR pathway in HKCs.	Curcumin	27-35	mechanistic target of rapamycin kinase	Homo sapiens	49-53
27829579-8	2017	Importantly, we found that curcumin reduced Akt, mTOR and P70S6K phosphorylation, effectively suppressing the activity of the Akt/mTOR pathway in HKCs.	Curcumin	27-35	AKT serine/threonine kinase 1	Homo sapiens	126-129
27829579-8	2017	Importantly, we found that curcumin reduced Akt, mTOR and P70S6K phosphorylation, effectively suppressing the activity of the Akt/mTOR pathway in HKCs.	Curcumin	27-35	mechanistic target of rapamycin kinase	Homo sapiens	130-134
27829579-9	2017	Curcumin also promoted HKC proliferation, and antagonized TGF-beta1-driven EMT through the inhibition of Akt/mTOR pathway activity, which may suggest an alternative therapy for renal fibrosis.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	58-67
27829579-9	2017	Curcumin also promoted HKC proliferation, and antagonized TGF-beta1-driven EMT through the inhibition of Akt/mTOR pathway activity, which may suggest an alternative therapy for renal fibrosis.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	105-108
27829579-9	2017	Curcumin also promoted HKC proliferation, and antagonized TGF-beta1-driven EMT through the inhibition of Akt/mTOR pathway activity, which may suggest an alternative therapy for renal fibrosis.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	109-113
28697568-7	2017	The effect of Abeta42 can be mimicked by PD98059 (an inhibitor of ERK1/2) and blocked by curcumin (an activator of MEK), which reveals Abeta-involved influence is via the decreased phosphorylation of MAPK-ERK1/2.	Curcumin	89-97	mitogen-activated protein kinase kinase 7	Homo sapiens	115-118
28697568-7	2017	The effect of Abeta42 can be mimicked by PD98059 (an inhibitor of ERK1/2) and blocked by curcumin (an activator of MEK), which reveals Abeta-involved influence is via the decreased phosphorylation of MAPK-ERK1/2.	Curcumin	89-97	mitogen-activated protein kinase 3	Homo sapiens	200-204
28697568-7	2017	The effect of Abeta42 can be mimicked by PD98059 (an inhibitor of ERK1/2) and blocked by curcumin (an activator of MEK), which reveals Abeta-involved influence is via the decreased phosphorylation of MAPK-ERK1/2.	Curcumin	89-97	mitogen-activated protein kinase 3	Homo sapiens	205-211
27128654-2	2017	Curcumin is a natural dietary product that inhibits NF-kappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	52-61
27983550-5	2017	In the present study, we evaluate the effect of curcumin derivatives on Abeta production in human neuroblastoma SH-SY5Y cells and in CHO cells which stably express human AbetaPP (CHO-AbetaPP).	Curcumin	48-56	amyloid beta precursor protein	Homo sapiens	72-77
27983550-6	2017	We found that the curcumin derivative CU6 was more effective than curcumin itself in reducing Abeta secretion.	Curcumin	18-26	amyloid beta precursor protein	Homo sapiens	94-99
27983550-6	2017	We found that the curcumin derivative CU6 was more effective than curcumin itself in reducing Abeta secretion.	Curcumin	66-74	amyloid beta precursor protein	Homo sapiens	94-99
28984591-4	2017	In this work, curcumin was found to bind to adult tau and fetal tau with a dissociation constant of 3.3+-0.4 and 8+-1 muM, respectively.	Curcumin	14-22	latexin	Homo sapiens	118-121
27231954-0	2017	Curcumin Promotes Osteosarcoma Cell Death by Activating miR-125a/ERRalpha Signal Pathway.	Curcumin	0-8	estrogen related receptor alpha	Homo sapiens	65-73
27231954-3	2017	By RNA sequence profiling, we found that curcumin significantly down-regulates the expression of estrogen-related receptor alpha (ERRalpha) in osteosarcoma cells.	Curcumin	41-49	estrogen related receptor alpha	Homo sapiens	97-128
27231954-3	2017	By RNA sequence profiling, we found that curcumin significantly down-regulates the expression of estrogen-related receptor alpha (ERRalpha) in osteosarcoma cells.	Curcumin	41-49	estrogen related receptor alpha	Homo sapiens	130-138
27231954-4	2017	Overexpression of ERRalpha diminished curcumin-activated apoptotic cell death and scavenged curcumin-induced reactive oxygen species (ROS), while ERRalpha silencing sensitized osteosarcoma cells to curcumin, resulting in increased inhibition of cell proliferation.	Curcumin	38-46	estrogen related receptor alpha	Homo sapiens	18-26
27231954-4	2017	Overexpression of ERRalpha diminished curcumin-activated apoptotic cell death and scavenged curcumin-induced reactive oxygen species (ROS), while ERRalpha silencing sensitized osteosarcoma cells to curcumin, resulting in increased inhibition of cell proliferation.	Curcumin	92-100	estrogen related receptor alpha	Homo sapiens	18-26
27231954-4	2017	Overexpression of ERRalpha diminished curcumin-activated apoptotic cell death and scavenged curcumin-induced reactive oxygen species (ROS), while ERRalpha silencing sensitized osteosarcoma cells to curcumin, resulting in increased inhibition of cell proliferation.	Curcumin	92-100	estrogen related receptor alpha	Homo sapiens	18-26
27231954-5	2017	In addition, we found that curcumin suppressed the ERRalpha gene expression through upregulation of miR-125a.	Curcumin	27-35	estrogen related receptor alpha	Homo sapiens	51-59
27231954-6	2017	Data from this study revealed a novel mechanism for curcumin-mediated apoptotic cell death, which involves tumor cell killing via activating miR-125a/ERRalpha pathway.	Curcumin	52-60	estrogen related receptor alpha	Homo sapiens	150-158
28605332-9	2017	Moreover, levels of superoxide dismutase, glutathione peroxidase, catalase, and glutathione, which were significantly decreased after carbofuran exposure, were increased by curcumin administration.	Curcumin	173-181	catalase	Rattus norvegicus	66-74
28244571-10	2017	Also, curcumin reduced the expression of IL-A, TNF-a and MIF levels in the lung tissues.	Curcumin	6-14	tumor necrosis factor	Rattus norvegicus	47-52
28244571-10	2017	Also, curcumin reduced the expression of IL-A, TNF-a and MIF levels in the lung tissues.	Curcumin	6-14	macrophage migration inhibitory factor	Rattus norvegicus	57-60
28286519-6	2017	In this paper we aim to review the involvement of ErbB proteins in cancer as well as the biologic activity of EGCG and curcumin in ErbB expressing and overexpressing malignancies.	Curcumin	119-127	epidermal growth factor receptor	Homo sapiens	131-135
27979493-7	2017	At last, curcumin treatment increased the expression of the tight junction proteins zonula occludens-1 and occludin in treated mice compared with vehicle-treated and sample SAH mice.	Curcumin	9-17	occludin	Mus musculus	107-115
27830358-0	2017	Curcumin inhibits growth of human breast cancer cells through demethylation of DLC1 promoter.	Curcumin	0-8	DLC1 Rho GTPase activating protein	Homo sapiens	79-83
27128654-6	2017	Curcumin and its analogues significantly inhibited VEGF-A synthesis and secretion in both cell lines in association with loss of HIF-1alpha, COX-2, and p-STAT-3 expression.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	51-57
27128654-6	2017	Curcumin and its analogues significantly inhibited VEGF-A synthesis and secretion in both cell lines in association with loss of HIF-1alpha, COX-2, and p-STAT-3 expression.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139
27128654-6	2017	Curcumin and its analogues significantly inhibited VEGF-A synthesis and secretion in both cell lines in association with loss of HIF-1alpha, COX-2, and p-STAT-3 expression.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	141-146
27128654-6	2017	Curcumin and its analogues significantly inhibited VEGF-A synthesis and secretion in both cell lines in association with loss of HIF-1alpha, COX-2, and p-STAT-3 expression.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	154-160
27128654-7	2017	Nuclear NF-kappaB expression was inhibited by curcumin, EF31, and UBS109.	Curcumin	46-54	nuclear factor kappa B subunit 1	Homo sapiens	8-17
27830358-4	2017	This study was designed to investigate the effect of curcumin on the expression of Deleted in Liver Cancer 1 (DLC1) in human breast cancer cell line MDA-MB-361 and the underlying mechanism in vitro and in vivo.	Curcumin	53-61	DLC1 Rho GTPase activating protein	Homo sapiens	83-108
27830358-4	2017	This study was designed to investigate the effect of curcumin on the expression of Deleted in Liver Cancer 1 (DLC1) in human breast cancer cell line MDA-MB-361 and the underlying mechanism in vitro and in vivo.	Curcumin	53-61	DLC1 Rho GTPase activating protein	Homo sapiens	110-114
28757910-0	2017	Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System.	Curcumin	0-8	kelch like ECH associated protein 1	Homo sapiens	64-69
27830358-5	2017	Curcumin induced DLC1 expression in a dose-dependent manner.	Curcumin	0-8	DLC1 Rho GTPase activating protein	Homo sapiens	17-21
27830358-6	2017	In curcumin-treated cells, methylation of DLC1 promoter was reduced and active forms of RhoA and Cdc42 were also decreased.	Curcumin	3-11	DLC1 Rho GTPase activating protein	Homo sapiens	42-46
27830358-6	2017	In curcumin-treated cells, methylation of DLC1 promoter was reduced and active forms of RhoA and Cdc42 were also decreased.	Curcumin	3-11	ras homolog family member A	Homo sapiens	88-92
27830358-9	2017	Consistent with the in vitro data, in vivo administration of curcumin inhibited the growth of implanted MDA-MB-361 cells and induced DLC1 expression in tumor tissue.	Curcumin	61-69	DLC1 Rho GTPase activating protein	Homo sapiens	133-137
27830358-10	2017	In MDA-MB-361 cells, curcumin down-regulates the expression of Sp1 to inhibit the expression of DNA methyltransferase 1, thus subsequently reducing hypermethylation of DLC1 promoter to induce DLC1 expression.	Curcumin	21-29	DLC1 Rho GTPase activating protein	Homo sapiens	168-172
27830358-10	2017	In MDA-MB-361 cells, curcumin down-regulates the expression of Sp1 to inhibit the expression of DNA methyltransferase 1, thus subsequently reducing hypermethylation of DLC1 promoter to induce DLC1 expression.	Curcumin	21-29	DLC1 Rho GTPase activating protein	Homo sapiens	192-196
28123572-0	2017	Solid lipid nanoparticles with TPGS and Brij 78: A co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro.	Curcumin	74-82	ATP binding cassette subfamily B member 1	Homo sapiens	110-124
28757910-0	2017	Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	70-74
28757910-1	2017	Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes).	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	213-217
29491534-11	2017	Curcumin also suppressed the expression of costimulatory molecules CD40L and CTLA-4, as well as PBMC proliferation.	Curcumin	0-8	CD40 ligand	Homo sapiens	67-72
30645874-1	2017	The purpose of the study was to determine the effects of curcumin (CUR) and quercetin (QUER) on the expression of genes and activity of prototypical Nrf2/ARE- and AhR/ XRE-regulated enzymes.	Curcumin	57-65	NFE2 like bZIP transcription factor 2	Rattus norvegicus	149-153
27030193-6	2016	Additionally, when compared to the vehicle-treated group, the curcumin-treated group showed reduced expression of cyclooxygenase-2 and nuclear factor-kappaB.	Curcumin	62-70	prostaglandin-endoperoxide synthase 2	Sus scrofa	114-130
27894084-0	2016	Curcumin increases exosomal TCF21 thus suppressing exosome-induced lung cancer.	Curcumin	0-8	transcription factor 21	Homo sapiens	28-33
27894084-4	2016	We hereby attempt to elucidate the correlation between curcumin treatment and TCF21 expression.	Curcumin	55-63	transcription factor 21	Homo sapiens	78-83
27894084-6	2016	An increase in TCF21 expression in response to curcumin was also seen, as revealed by real-time PCR (RT-PCR) and western blot.	Curcumin	47-55	transcription factor 21	Homo sapiens	15-20
27764939-0	2016	Nrf2 Knockdown Disrupts the Protective Effect of Curcumin on Alcohol-Induced Hepatocyte Necroptosis.	Curcumin	49-57	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
27894084-10	2016	Therefore, curcumin exerts its anti-cancer function by downregulating DNMT1, thereby upregulating TCF21.	Curcumin	11-19	transcription factor 21	Homo sapiens	98-103
27838230-4	2016	Activation of Nrf2 by these curcumin analogues is responsible for the amendment of the antioxidant status, impairment of NF-kappaB signal, thus attenuate the nephrotoxicity induced post-gamma-irradiation exposure.	Curcumin	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	14-18
27838230-6	2016	In conclusion, the results of the present study demonstrate a promising role of these new curcumin analogues to attenuate the early symptoms of nephrotoxicity induced by gamma-irradiation in rats via activation of Nrf2 gene expression.	Curcumin	90-98	NFE2 like bZIP transcription factor 2	Rattus norvegicus	214-218
27764939-2	2016	Our previous study has identified that the beneficial therapeutic effect of curcumin on alcohol-caused liver injury might be attributed to activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), whereas the role of curcumin in regulating necroptosis and the underlying mechanism remain to be determined.	Curcumin	76-84	nuclear factor, erythroid derived 2, like 2	Mus musculus	198-202
27980427-0	2016	Curcumin sensitizes human gastric cancer cells to 5-fluorouracil through inhibition of the NFkappaB survival-signaling pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	91-99
27764939-4	2016	Curcumin dose-dependently ameliorated hepatocyte necroptosis and alleviated alcohol-caused decrease in hepatic Nrf2 expression in alcoholic mice.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115
27980427-6	2016	Curcumin, a natural compound, can reverse 5-FU resistance and inhibits proliferation in GC cells by downregulating the NFkappaB-signaling pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	119-127
27764939-6	2016	Our results indicated that Nrf2 knockdown aggravated the effects of alcohol on liver injury and necroptosis and even abrogated the inhibitory effect of curcumin on necroptosis.	Curcumin	152-160	nuclear factor, erythroid derived 2, like 2	Mus musculus	27-31
27764939-7	2016	Further, activated Nrf2 by curcumin inhibited p53 expression in both livers and cultured hepatocytes under alcohol stimulation.	Curcumin	27-35	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23
27764939-8	2016	The next in vitro experiments, similar to in vivo ones, revealed that although Nrf2 knockdown abolished the suppression of curcumin on necroptosis of hepatocytes exposed to ethanol, p53 siRNA could clearly rescued the relative effect of curcumin.	Curcumin	123-131	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
27764939-9	2016	In summary, for the first time, we concluded that curcumin attenuated alcohol-induced hepatocyte necroptosis in a Nrf2/p53-dependent mechanism.	Curcumin	50-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118
27789120-8	2016	Curcumin was found to exert diverse immunomodulatory effects, including suppression of IL-4, IL-8, and tumor necrosis factor alpha and increased production of IL-10 and soluble intercellular adhesion molecule.	Curcumin	0-8	interleukin 4	Homo sapiens	87-91
27789120-8	2016	Curcumin was found to exert diverse immunomodulatory effects, including suppression of IL-4, IL-8, and tumor necrosis factor alpha and increased production of IL-10 and soluble intercellular adhesion molecule.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
27789120-8	2016	Curcumin was found to exert diverse immunomodulatory effects, including suppression of IL-4, IL-8, and tumor necrosis factor alpha and increased production of IL-10 and soluble intercellular adhesion molecule.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	103-130
27766504-8	2016	CONCLUSION: Our results show that curcumin pretreatment decreased the expression of alpha smooth muscle actin (alpha-SMA), matrix metalloproteinases-9 (MMP-9) and changed the expression of tissue inhibitors of metalloproteinase (TIMP-1) after PQ intoxication.	Curcumin	34-42	actin alpha 2, smooth muscle, aorta	Mus musculus	84-109
27657825-0	2016	Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling.	Curcumin	0-8	notch receptor 1	Homo sapiens	115-120
27657825-2	2016	Notch signaling regulates prostate cancer apoptosis, but it is still unknown whether curcumin induces apoptosis in DU-145 cells by regulating Notch pathway.	Curcumin	85-93	notch receptor 1	Homo sapiens	142-147
27657825-3	2016	The aim of this study was to investigate the effect of curcumin on regulating Notch signaling and provide basic data for using curcumin in prostate cancer therapy.	Curcumin	55-63	notch receptor 1	Homo sapiens	78-83
27657825-7	2016	In order to study whether Notch 1 expression could be downregulated by curcumin, Notch 1 siRNA and Notch 1 plasmid were used in Notch 1 down-regulation and over-expression.	Curcumin	71-79	notch receptor 1	Homo sapiens	26-33
27657825-9	2016	RESULTS: We found that Notch 1 signaling was down regulated in Notch 1 siRNA or Notch 1 plasmid transfected 145 cells after curcumin treatment.	Curcumin	124-132	notch receptor 1	Homo sapiens	23-30
27657825-9	2016	RESULTS: We found that Notch 1 signaling was down regulated in Notch 1 siRNA or Notch 1 plasmid transfected 145 cells after curcumin treatment.	Curcumin	124-132	notch receptor 1	Homo sapiens	63-70
27657825-9	2016	RESULTS: We found that Notch 1 signaling was down regulated in Notch 1 siRNA or Notch 1 plasmid transfected 145 cells after curcumin treatment.	Curcumin	124-132	notch receptor 1	Homo sapiens	63-70
27657825-12	2016	The apoptosis related protein p53 expression was increased, and apoptosis suppressor Bcl-2 was inhibited in DU-145 after curcumin treatment.	Curcumin	121-129	tumor protein p53	Homo sapiens	30-33
27657825-12	2016	The apoptosis related protein p53 expression was increased, and apoptosis suppressor Bcl-2 was inhibited in DU-145 after curcumin treatment.	Curcumin	121-129	BCL2 apoptosis regulator	Homo sapiens	85-90
27657825-13	2016	Additionally, Caspase-3 and Caspase-9 were activated by curcumin.	Curcumin	56-64	caspase 3	Homo sapiens	14-23
27657825-14	2016	CONCLUSION: Curcumin induced apoptosis and G0/G1 arrest in DU-145 cells by down regulating Notch signaling.	Curcumin	12-20	notch receptor 1	Homo sapiens	91-96
27194111-0	2016	Curcumin Inhibits 5-Fluorouracil-induced Up-regulation of CXCL1 and CXCL2 of the Colon Associated with Attenuation of Diarrhoea Development.	Curcumin	0-8	chemokine (C-X-C motif) ligand 1	Mus musculus	58-63
27194111-0	2016	Curcumin Inhibits 5-Fluorouracil-induced Up-regulation of CXCL1 and CXCL2 of the Colon Associated with Attenuation of Diarrhoea Development.	Curcumin	0-8	chemokine (C-X-C motif) ligand 2	Mus musculus	68-73
27194111-12	2016	Under this condition, the CXCL1 and CXCL2 gene up-regulated by 5-FU administration was inhibited by curcumin.	Curcumin	100-108	chemokine (C-X-C motif) ligand 1	Mus musculus	26-31
27194111-12	2016	Under this condition, the CXCL1 and CXCL2 gene up-regulated by 5-FU administration was inhibited by curcumin.	Curcumin	100-108	chemokine (C-X-C motif) ligand 2	Mus musculus	36-41
27194111-14	2016	The 5-FU-induced up-regulated CXCL1 and CXCL2 gene expressions were inhibited by curcumin, Bay-117082 and bortezomib, nuclear factor kappa B (NF-kappaB) inhibitors, C646, a p300/cyclic adenosine monophosphate response element-binding protein-histone acetyltransferase (HAT) inhibitor.	Curcumin	81-89	chemokine (C-X-C motif) ligand 1	Mus musculus	30-35
27194111-14	2016	The 5-FU-induced up-regulated CXCL1 and CXCL2 gene expressions were inhibited by curcumin, Bay-117082 and bortezomib, nuclear factor kappa B (NF-kappaB) inhibitors, C646, a p300/cyclic adenosine monophosphate response element-binding protein-histone acetyltransferase (HAT) inhibitor.	Curcumin	81-89	chemokine (C-X-C motif) ligand 2	Mus musculus	40-45
27194111-14	2016	The 5-FU-induced up-regulated CXCL1 and CXCL2 gene expressions were inhibited by curcumin, Bay-117082 and bortezomib, nuclear factor kappa B (NF-kappaB) inhibitors, C646, a p300/cyclic adenosine monophosphate response element-binding protein-histone acetyltransferase (HAT) inhibitor.	Curcumin	81-89	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
27194111-15	2016	In conclusion, these findings suggested that curcumin prevented the development of diarrhoea by inhibiting NF-kappaB and HAT activation.	Curcumin	45-53	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	107-116
28105120-0	2016	Effects of curcumin on the apoptosis of cardiomyocytes and the expression of NF-kappaB, PPAR-gamma and Bcl-2 in rats with myocardial infarction injury.	Curcumin	11-19	BCL2, apoptosis regulator	Rattus norvegicus	103-108
28105120-8	2016	The results of the reverse transcription-polymerase chain reaction indicated that curcumin treatment significantly increased the mRNA expression levels of Bcl-2 (P&lt;0.01).	Curcumin	82-90	BCL2, apoptosis regulator	Rattus norvegicus	155-160
28105120-9	2016	Therefore, curcumin antagonizes cardiomyocyte apoptosis and inhibits inflammatory cell infiltration following myocardial infarction, which may be associated with its inhibitory effects on the expression of NF-kappaB, and activating effects on the expression of PPAR-gamma and Bcl-2 in myocardial cells.	Curcumin	11-19	BCL2, apoptosis regulator	Rattus norvegicus	276-281
27466310-7	2016	After the administration of curcumin for 6 months, the results showed that the expression of an insulin receptor (InR) and insulin receptor substrate (IRS)-1 decreased in the hippocampal CA1 area of the APPswe/PS1dE9 double transgenic mice, while the expression of phosphatidylinositol-3 kinase (PI3K), phosphorylated PI3K (p-PI3K), serine-threonine kinase (AKT) and phosphorylated AKT (p-AKT) increased.	Curcumin	28-36	thymoma viral proto-oncogene 1	Mus musculus	358-361
27466310-7	2016	After the administration of curcumin for 6 months, the results showed that the expression of an insulin receptor (InR) and insulin receptor substrate (IRS)-1 decreased in the hippocampal CA1 area of the APPswe/PS1dE9 double transgenic mice, while the expression of phosphatidylinositol-3 kinase (PI3K), phosphorylated PI3K (p-PI3K), serine-threonine kinase (AKT) and phosphorylated AKT (p-AKT) increased.	Curcumin	28-36	thymoma viral proto-oncogene 1	Mus musculus	382-385
27466310-7	2016	After the administration of curcumin for 6 months, the results showed that the expression of an insulin receptor (InR) and insulin receptor substrate (IRS)-1 decreased in the hippocampal CA1 area of the APPswe/PS1dE9 double transgenic mice, while the expression of phosphatidylinositol-3 kinase (PI3K), phosphorylated PI3K (p-PI3K), serine-threonine kinase (AKT) and phosphorylated AKT (p-AKT) increased.	Curcumin	28-36	thymoma viral proto-oncogene 1	Mus musculus	382-385
27766504-8	2016	CONCLUSION: Our results show that curcumin pretreatment decreased the expression of alpha smooth muscle actin (alpha-SMA), matrix metalloproteinases-9 (MMP-9) and changed the expression of tissue inhibitors of metalloproteinase (TIMP-1) after PQ intoxication.	Curcumin	34-42	actin alpha 2, smooth muscle, aorta	Mus musculus	111-120
27766504-8	2016	CONCLUSION: Our results show that curcumin pretreatment decreased the expression of alpha smooth muscle actin (alpha-SMA), matrix metalloproteinases-9 (MMP-9) and changed the expression of tissue inhibitors of metalloproteinase (TIMP-1) after PQ intoxication.	Curcumin	34-42	tissue inhibitor of metalloproteinase 1	Mus musculus	229-235
28053624-13	2016	Cancer cells treated with DM-2-8 and curcumin showed activation of caspase-9 and caspase-3 as downstream molecular components of the apoptotic pathway.	Curcumin	37-45	caspase 3	Homo sapiens	81-90
28096969-9	2016	CONCLUSION: The findings of the current study suggest that our combination strategy, which merges two detached gene (p53) and drug (curcumin) delivery systems into an integrated platform, may represent huge potential as a novel and efficient modality for glioblastoma treatment.	Curcumin	132-140	tumor protein p53	Homo sapiens	117-120
27779649-5	2016	Results indicated that curcumin combined with paclitaxel decreased c-Ha-Ras, Rho-A, p53 and Bcl-xL gene expression in comparison to control and substances alone in MCF-7 cell line.	Curcumin	23-31	ras homolog family member A	Homo sapiens	77-82
27779649-5	2016	Results indicated that curcumin combined with paclitaxel decreased c-Ha-Ras, Rho-A, p53 and Bcl-xL gene expression in comparison to control and substances alone in MCF-7 cell line.	Curcumin	23-31	tumor protein p53	Homo sapiens	84-87
27779649-5	2016	Results indicated that curcumin combined with paclitaxel decreased c-Ha-Ras, Rho-A, p53 and Bcl-xL gene expression in comparison to control and substances alone in MCF-7 cell line.	Curcumin	23-31	BCL2 like 1	Homo sapiens	92-98
27779649-9	2016	However, curcumin alone decreased IkappaBalpha and Stat-3 gene expression.	Curcumin	9-17	NFKB inhibitor alpha	Homo sapiens	34-46
27779649-9	2016	However, curcumin alone decreased IkappaBalpha and Stat-3 gene expression.	Curcumin	9-17	signal transducer and activator of transcription 3	Homo sapiens	51-57
27779649-11	2016	Curcumin alone and combined with paclitaxel increased p53, Bid, caspase-3, caspase-8 and Bax gene expression in MDA-MB-231, whereas Bcl-xL decreased such expression in MDA-MB-231 cells.	Curcumin	0-8	tumor protein p53	Homo sapiens	54-57
27779649-11	2016	Curcumin alone and combined with paclitaxel increased p53, Bid, caspase-3, caspase-8 and Bax gene expression in MDA-MB-231, whereas Bcl-xL decreased such expression in MDA-MB-231 cells.	Curcumin	0-8	BH3 interacting domain death agonist	Homo sapiens	59-62
27779649-11	2016	Curcumin alone and combined with paclitaxel increased p53, Bid, caspase-3, caspase-8 and Bax gene expression in MDA-MB-231, whereas Bcl-xL decreased such expression in MDA-MB-231 cells.	Curcumin	0-8	caspase 3	Homo sapiens	64-73
27779649-11	2016	Curcumin alone and combined with paclitaxel increased p53, Bid, caspase-3, caspase-8 and Bax gene expression in MDA-MB-231, whereas Bcl-xL decreased such expression in MDA-MB-231 cells.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	89-92
27779649-12	2016	When paclitaxel and curcumin were combined the expression of Bcl-2 protein was decreased.	Curcumin	20-28	BCL2 apoptosis regulator	Homo sapiens	61-66
27000932-0	2016	In vivo effects of curcumin on the paraoxonase, carbonic anhydrase, glucose-6-phosphate dehydrogenase and beta-glucosidase enzyme activities in dextran sulphate sodium-induced ulcerative colitis mice.	Curcumin	19-27	paraoxonase 1	Mus musculus	35-46
27000932-2	2016	Here we investigate whether prophylactic and therapeutic application of the curcumin alters the enzyme activities of paraoxonase (PON), carbonic anhydrase (CA), glucose-6-phosphate dehydrogenase (G6PD) and cytosolic beta-glucosidase in dextran sulphate sodium (DSS)-induced ulcerative colitis mice.	Curcumin	76-84	paraoxonase 1	Mus musculus	117-128
27000932-2	2016	Here we investigate whether prophylactic and therapeutic application of the curcumin alters the enzyme activities of paraoxonase (PON), carbonic anhydrase (CA), glucose-6-phosphate dehydrogenase (G6PD) and cytosolic beta-glucosidase in dextran sulphate sodium (DSS)-induced ulcerative colitis mice.	Curcumin	76-84	paraoxonase 1	Mus musculus	130-133
27000932-4	2016	DSS-induced decrease in liver and serum PON activities were completely recovered by prophylactic administration of curcumin.	Curcumin	115-123	paraoxonase 1	Mus musculus	40-43
27325106-4	2016	Curcumin exerts its anticancer effect through a complicated molecular signaling network, involving proliferation, estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) pathways.	Curcumin	0-8	estrogen receptor 1	Homo sapiens	114-131
27521081-4	2016	Using human neuroblastoma (SHSY5Y) cells, curcumin and Abeta, we studied the protective effects of curcumin against Abeta.	Curcumin	99-107	amyloid beta precursor protein	Homo sapiens	116-121
27521081-12	2016	Interestingly, curcumin pre- and post-treated cells incubated with Abeta showed reduced mitochondrial dysfunction, and maintained cell viability and mitochondrial dynamics, mitochondrial biogenesis and synaptic activity.	Curcumin	15-23	amyloid beta precursor protein	Homo sapiens	67-72
27751588-0	2016	Development and Characterization of FLT3-Specific Curcumin-Loaded Polymeric Micelles as a Drug Delivery System for Treating FLT3-Overexpressing Leukemic Cells.	Curcumin	50-58	fms related receptor tyrosine kinase 3	Homo sapiens	36-40
27751588-1	2016	This study aimed at developing a curcumin (CM) nanoparticle targeted to Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 (FLT3) protein on the surface of leukemic cells and at evaluating their properties, specificity, cytotoxicity, and inhibitory effect on FLT3 protein level in FLT3-overexpressing leukemic cells, EoL-1, and MV-4-11 cells.	Curcumin	33-41	fms related receptor tyrosine kinase 3	Homo sapiens	72-125
27751588-1	2016	This study aimed at developing a curcumin (CM) nanoparticle targeted to Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 (FLT3) protein on the surface of leukemic cells and at evaluating their properties, specificity, cytotoxicity, and inhibitory effect on FLT3 protein level in FLT3-overexpressing leukemic cells, EoL-1, and MV-4-11 cells.	Curcumin	33-41	fms related receptor tyrosine kinase 3	Homo sapiens	127-131
27751588-1	2016	This study aimed at developing a curcumin (CM) nanoparticle targeted to Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 (FLT3) protein on the surface of leukemic cells and at evaluating their properties, specificity, cytotoxicity, and inhibitory effect on FLT3 protein level in FLT3-overexpressing leukemic cells, EoL-1, and MV-4-11 cells.	Curcumin	33-41	fms related receptor tyrosine kinase 3	Homo sapiens	262-266
27751588-1	2016	This study aimed at developing a curcumin (CM) nanoparticle targeted to Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 (FLT3) protein on the surface of leukemic cells and at evaluating their properties, specificity, cytotoxicity, and inhibitory effect on FLT3 protein level in FLT3-overexpressing leukemic cells, EoL-1, and MV-4-11 cells.	Curcumin	33-41	fms related receptor tyrosine kinase 3	Homo sapiens	262-266
27878252-6	2016	The ERK1/2 specific inhibitor, U0126, augmented the inhibitory effects of TMZ on the proliferation, migration and invasion of the glioma C6 cells, and the mitogen-activated protein kinase kinase/ERK pathway activator, curcumin, attenuated the inhibitory effects of TMZ on the proliferation and motility of the glioma C6 cells.	Curcumin	218-226	mitogen-activated protein kinase 3	Homo sapiens	4-10
27521081-0	2016	Protective effects of a natural product, curcumin, against amyloid beta induced mitochondrial and synaptic toxicities in Alzheimer"s disease.	Curcumin	41-49	amyloid beta precursor protein	Homo sapiens	59-71
27534650-9	2016	Nanocurcumin treatment prevented lung edema formation and restored expression levels of ET-1/2/3 and its receptors while restoring the blood analytes, circulatory cytokines and pulmonary redox status better than curcumin.	Curcumin	4-12	endothelin 1	Rattus norvegicus	88-96
27878252-7	2016	Additionally, the western blotting in the present study demonstrated that TMZ and U0126 decreased the expression of vascular endothelial growth factor-C (VEGF-C), and the expression level was restored by curcumin, suggesting that VEGF-C may be the downstream effector of ERK1/2.	Curcumin	204-212	vascular endothelial growth factor C	Homo sapiens	116-152
27878252-7	2016	Additionally, the western blotting in the present study demonstrated that TMZ and U0126 decreased the expression of vascular endothelial growth factor-C (VEGF-C), and the expression level was restored by curcumin, suggesting that VEGF-C may be the downstream effector of ERK1/2.	Curcumin	204-212	vascular endothelial growth factor C	Homo sapiens	154-160
27878252-6	2016	The ERK1/2 specific inhibitor, U0126, augmented the inhibitory effects of TMZ on the proliferation, migration and invasion of the glioma C6 cells, and the mitogen-activated protein kinase kinase/ERK pathway activator, curcumin, attenuated the inhibitory effects of TMZ on the proliferation and motility of the glioma C6 cells.	Curcumin	218-226	mitogen-activated protein kinase 1	Homo sapiens	4-7
27878252-7	2016	Additionally, the western blotting in the present study demonstrated that TMZ and U0126 decreased the expression of vascular endothelial growth factor-C (VEGF-C), and the expression level was restored by curcumin, suggesting that VEGF-C may be the downstream effector of ERK1/2.	Curcumin	204-212	vascular endothelial growth factor C	Homo sapiens	230-236
27325106-4	2016	Curcumin exerts its anticancer effect through a complicated molecular signaling network, involving proliferation, estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) pathways.	Curcumin	0-8	estrogen receptor 1	Homo sapiens	133-135
27878252-7	2016	Additionally, the western blotting in the present study demonstrated that TMZ and U0126 decreased the expression of vascular endothelial growth factor-C (VEGF-C), and the expression level was restored by curcumin, suggesting that VEGF-C may be the downstream effector of ERK1/2.	Curcumin	204-212	mitogen-activated protein kinase 3	Homo sapiens	271-277
27325106-4	2016	Curcumin exerts its anticancer effect through a complicated molecular signaling network, involving proliferation, estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) pathways.	Curcumin	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	148-182
27325106-4	2016	Curcumin exerts its anticancer effect through a complicated molecular signaling network, involving proliferation, estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) pathways.	Curcumin	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	184-188
28105206-0	2016	Curcumin enhances temsirolimus-induced apoptosis in human renal carcinoma cells through upregulation of YAP/p53.	Curcumin	0-8	tumor protein p53	Homo sapiens	108-111
28105222-10	2016	Furthermore, while curcumin induced cell apoptosis and enhanced the expression ratio of Bax/Bcl-2, which are downstream molecules of p53, ectopic expression of H19 inhibited curcumin-induced cell apoptosis.	Curcumin	19-27	BCL2 associated X, apoptosis regulator	Homo sapiens	88-91
28105222-10	2016	Furthermore, while curcumin induced cell apoptosis and enhanced the expression ratio of Bax/Bcl-2, which are downstream molecules of p53, ectopic expression of H19 inhibited curcumin-induced cell apoptosis.	Curcumin	19-27	BCL2 apoptosis regulator	Homo sapiens	92-97
28105222-10	2016	Furthermore, while curcumin induced cell apoptosis and enhanced the expression ratio of Bax/Bcl-2, which are downstream molecules of p53, ectopic expression of H19 inhibited curcumin-induced cell apoptosis.	Curcumin	19-27	tumor protein p53	Homo sapiens	133-136
27241764-10	2016	Curcumin supplementation significantly lowered TAG content and decreased the protein expression of LXR-alpha (43%) and SREBP1c (59%) in the liver.	Curcumin	0-8	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	99-108
28105206-5	2016	Co-treatment with temsirolimus and curcumin led to the activation of cleaved poly ADP-ribose polymerase and caspase 3, upregulation of p53 expression and nuclear translocation, and downregulation of B-cell lymphoma 2 protein expression.	Curcumin	35-43	poly(ADP-ribose) polymerase 1	Homo sapiens	77-103
28105206-5	2016	Co-treatment with temsirolimus and curcumin led to the activation of cleaved poly ADP-ribose polymerase and caspase 3, upregulation of p53 expression and nuclear translocation, and downregulation of B-cell lymphoma 2 protein expression.	Curcumin	35-43	caspase 3	Homo sapiens	108-117
28105206-5	2016	Co-treatment with temsirolimus and curcumin led to the activation of cleaved poly ADP-ribose polymerase and caspase 3, upregulation of p53 expression and nuclear translocation, and downregulation of B-cell lymphoma 2 protein expression.	Curcumin	35-43	tumor protein p53	Homo sapiens	135-138
28105206-6	2016	Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells.	Curcumin	13-21	tumor protein p53	Homo sapiens	198-201
28105206-6	2016	Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells.	Curcumin	13-21	tumor protein p53	Homo sapiens	321-324
28105206-6	2016	Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells.	Curcumin	159-167	tumor protein p53	Homo sapiens	198-201
28105206-6	2016	Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells.	Curcumin	159-167	tumor protein p53	Homo sapiens	321-324
28105206-6	2016	Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells.	Curcumin	159-167	tumor protein p53	Homo sapiens	198-201
28105206-6	2016	Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells.	Curcumin	159-167	tumor protein p53	Homo sapiens	321-324
28105206-7	2016	In conclusion, the present results indicate that combined curcumin and temsirolimus treatment has a synergistic effect on apoptosis in human RCC cells, through the activation of p53.	Curcumin	58-66	tumor protein p53	Homo sapiens	178-181
28105206-8	2016	Mechanistically, YAP is essential in the induction of p53 expression by curcumin.	Curcumin	72-80	tumor protein p53	Homo sapiens	54-57
28105222-1	2016	Curcumin, a major phytochemical in turmeric, inhibits the proliferation of many types of solid cancer cells by enhancing p53 expression.	Curcumin	0-8	tumor protein p53	Homo sapiens	121-124
28105222-7	2016	The protein expression of p53, B-cell lymphoma (Bcl)-2, Bcl-2-associated X protein (Bax) and c-Myc in curcumin-treated cells was detected by western blotting.	Curcumin	102-110	tumor protein p53	Homo sapiens	26-29
28105222-7	2016	The protein expression of p53, B-cell lymphoma (Bcl)-2, Bcl-2-associated X protein (Bax) and c-Myc in curcumin-treated cells was detected by western blotting.	Curcumin	102-110	BCL2 apoptosis regulator	Homo sapiens	31-54
28105222-7	2016	The protein expression of p53, B-cell lymphoma (Bcl)-2, Bcl-2-associated X protein (Bax) and c-Myc in curcumin-treated cells was detected by western blotting.	Curcumin	102-110	BCL2 associated X, apoptosis regulator	Homo sapiens	56-82
28105222-7	2016	The protein expression of p53, B-cell lymphoma (Bcl)-2, Bcl-2-associated X protein (Bax) and c-Myc in curcumin-treated cells was detected by western blotting.	Curcumin	102-110	BCL2 associated X, apoptosis regulator	Homo sapiens	84-87
27916071-8	2016	The expreesion of NF-kappaB in the 12.5, 25, 50 mumol/L curcumin+LPS groups were (0.80+-0.07) , (0.74+-0.05) , (0.49+-0.19) times to the LPS group, with statistically significant difference(P&lt;0.01).	Curcumin	56-64	nuclear factor kappa B subunit 1	Homo sapiens	18-27
27994638-7	2016	It could be an excellent radio-imaging agent that targeting tumor cells via targeting of P-12-LOX.Graphical abstractThis novel curcumin derivative was successfully synthesized and radiolabeled with technetium-99m and biologically evaluated in tumor bearing mice that showed high accumulation in solid tumor with target/non-target ratio &gt;6 confirming the affinity predicted by the docking results.	Curcumin	127-135	polymerase (DNA-directed), delta 4	Mus musculus	89-97
27916071-19	2016	Conclusion: The treatment of curcumin could downregulate the expression of NF-kappaB/miR-155, thus inhibit NF-kappaB signal pathway and the apoptosis of extravillus trophoblast cells, and protect their invasive ability.	Curcumin	29-37	nuclear factor kappa B subunit 1	Homo sapiens	75-84
27932984-0	2016	Curcumin Suppressed Activation of Dendritic Cells via JAK/STAT/SOCS Signal in Mice with Experimental Colitis.	Curcumin	0-8	cytokine inducible SH2-containing protein	Mus musculus	63-67
27916071-19	2016	Conclusion: The treatment of curcumin could downregulate the expression of NF-kappaB/miR-155, thus inhibit NF-kappaB signal pathway and the apoptosis of extravillus trophoblast cells, and protect their invasive ability.	Curcumin	29-37	nuclear factor kappa B subunit 1	Homo sapiens	107-116
27932984-4	2016	In the present study, we explored the mechanism of curcumin treated experimental colitis by observing activation of DCs via JAK/STAT/SOCS signaling pathway in colitis mice.	Curcumin	51-59	cytokine inducible SH2-containing protein	Mus musculus	133-137
27932984-9	2016	In conclusion, curcumin suppressed the activation of DCs by modulating the JAK/STAT/SOCS signaling pathway to restore immunologic balance to effectively treat experimental colitis.	Curcumin	15-23	cytokine inducible SH2-containing protein	Mus musculus	84-88
27729449-4	2016	Co-immunoprecipitation and chemical cross-linking studies previously revealed that the N-terminal sterile alpha motif (or SAM) domain of SMSr drives self-assembly of the protein into oligomers and that SMSr oligomerization is promoted by curcumin, a drug known to perturb ER ceramide and calcium homeostasis.	Curcumin	238-246	sterile alpha motif domain containing 8	Homo sapiens	137-141
27412471-3	2016	Curcumin prevented maleate-induced proteinuria, increased heat shock protein of 72 KDa (Hsp72) expression, and decreased plasma glutathione peroxidase activity.	Curcumin	0-8	heat shock protein family A (Hsp70) member 1A	Homo sapiens	58-86
27904665-11	2016	(3) ELISA showed IL-8 in the supernatant increased significantly in a time dependent manner after HCY treatment (P&lt;0.01), but curcumin could significantly inhibit the IL-8 secretion in endothelial cells after HCY treatment.	Curcumin	129-137	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
27904665-13	2016	CONCLUSION: Curcumin is able to protect the endothelial cells against HCY induced injury through inhibiting NF-kappaB activation and down-regulating IL-8 expression.	Curcumin	12-20	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
27689333-2	2016	It has been reported that Curcumin can induce autophagy through inhibition of the Akt-mTOR pathway.	Curcumin	26-34	AKT serine/threonine kinase 1	Homo sapiens	82-85
27689333-2	2016	It has been reported that Curcumin can induce autophagy through inhibition of the Akt-mTOR pathway.	Curcumin	26-34	mechanistic target of rapamycin kinase	Homo sapiens	86-90
27689333-6	2016	Second, Curcumin is capable of suppressing the mammalian target of rapamycin (mTOR).	Curcumin	8-16	mechanistic target of rapamycin kinase	Homo sapiens	47-76
27689333-6	2016	Second, Curcumin is capable of suppressing the mammalian target of rapamycin (mTOR).	Curcumin	8-16	mechanistic target of rapamycin kinase	Homo sapiens	78-82
27412471-6	2016	The maleate-induced epithelial damage, evaluated by claudin-2 and occludin expressions, was ameliorated by curcumin.	Curcumin	107-115	claudin 2	Homo sapiens	52-61
27412471-3	2016	Curcumin prevented maleate-induced proteinuria, increased heat shock protein of 72 KDa (Hsp72) expression, and decreased plasma glutathione peroxidase activity.	Curcumin	0-8	heat shock protein family A (Hsp70) member 1A	Homo sapiens	88-93
27831553-9	2016	Furthermore, NF-kappaB inhibitors, JSH-23 and curcumin reduced IL-6 secretion from RS-like cells.	Curcumin	46-54	interleukin 6	Homo sapiens	63-67
27832139-8	2016	In summary, curcumin treatment might produce a P73-dependent apoptotic cell death in chronic myelogenous leukemia cells (K562), which was triggered by mitotic catastrophe, due to sustained BAX and survivin expression and impairment of the anti-apoptotic proteins BCL-2 and XIAP.	Curcumin	12-20	BCL2 associated X, apoptosis regulator	Homo sapiens	189-192
27832139-8	2016	In summary, curcumin treatment might produce a P73-dependent apoptotic cell death in chronic myelogenous leukemia cells (K562), which was triggered by mitotic catastrophe, due to sustained BAX and survivin expression and impairment of the anti-apoptotic proteins BCL-2 and XIAP.	Curcumin	12-20	BCL2 apoptosis regulator	Homo sapiens	263-268
27569031-0	2016	Nanomedicine based curcumin and doxorubicin combination treatment of glioblastoma with scFv-targeted micelles: In vitro evaluation on 2D and 3D tumor models.	Curcumin	19-27	immunglobulin heavy chain variable region	Homo sapiens	87-91
27834897-0	2016	Curcumin as a Modulator of P-Glycoprotein in Cancer: Challenges and Perspectives.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	27-41
27834897-5	2016	Curcumin is a secondary metabolite isolated from the turmeric of Curcuma longa L. which has been associated with several biological activities, particularly P-gp modulatory activity (by inhibiting both P-gp function and expression).	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	157-161
27834897-5	2016	Curcumin is a secondary metabolite isolated from the turmeric of Curcuma longa L. which has been associated with several biological activities, particularly P-gp modulatory activity (by inhibiting both P-gp function and expression).	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	202-206
27834897-6	2016	However, curcumin shows extensive metabolism and instability, which has justified the recent and intensive search for analogs of curcumin that maintain the P-gp modulatory activity but have enhanced stability.	Curcumin	129-137	ATP binding cassette subfamily B member 1	Homo sapiens	156-160
27834897-7	2016	This review summarizes and compares the effects of curcumin and several curcumin analogs on P-glycoprotein function and expression, emphasizing the potential of these molecules for the possible development of safe and effective inhibitors of P-gp to overcome MDR in human cancer.	Curcumin	51-59	ATP binding cassette subfamily B member 1	Homo sapiens	92-106
27834897-7	2016	This review summarizes and compares the effects of curcumin and several curcumin analogs on P-glycoprotein function and expression, emphasizing the potential of these molecules for the possible development of safe and effective inhibitors of P-gp to overcome MDR in human cancer.	Curcumin	51-59	ATP binding cassette subfamily B member 1	Homo sapiens	242-246
27834897-7	2016	This review summarizes and compares the effects of curcumin and several curcumin analogs on P-glycoprotein function and expression, emphasizing the potential of these molecules for the possible development of safe and effective inhibitors of P-gp to overcome MDR in human cancer.	Curcumin	72-80	ATP binding cassette subfamily B member 1	Homo sapiens	92-106
27834897-7	2016	This review summarizes and compares the effects of curcumin and several curcumin analogs on P-glycoprotein function and expression, emphasizing the potential of these molecules for the possible development of safe and effective inhibitors of P-gp to overcome MDR in human cancer.	Curcumin	72-80	ATP binding cassette subfamily B member 1	Homo sapiens	242-246
27877129-9	2016	In addition, curcumin and rosiglitazone inhibited collagen-1 secretion and alpha-SMA expression in mouse lung fibroblasts.	Curcumin	13-21	actin alpha 2, smooth muscle, aorta	Mus musculus	75-84
27877129-11	2016	In conclusion, our study reveals novel mechanism by which curcumin inhibits TGF-beta2 driven differentiation of lung fibroblasts to myofibroblasts.	Curcumin	58-66	transforming growth factor, beta 2	Mus musculus	76-85
29906037-9	2016	Therefore, dietary curcumin might have efficacy to ameliorate diabetic complications in terms of controlling and modulating inflammatory parameters, including IL-13, and TNF-alpha.	Curcumin	19-27	interleukin 13	Rattus norvegicus	159-164
29906037-9	2016	Therefore, dietary curcumin might have efficacy to ameliorate diabetic complications in terms of controlling and modulating inflammatory parameters, including IL-13, and TNF-alpha.	Curcumin	19-27	tumor necrosis factor	Rattus norvegicus	170-179
29906037-11	2016	The potential beneficial effects of curcumin have been shown to decline the inflammatory of liver tissue, concerning illustration of IL-13, and TNF-alpha.	Curcumin	36-44	interleukin 13	Rattus norvegicus	133-138
29906037-0	2016	Effect of Curcumin on Characterization and Localization of Interleukin-13 and Tumor Necrosis Factor-alpha in Liver of Diabetic Rats.	Curcumin	10-18	interleukin 13	Rattus norvegicus	59-73
29906037-0	2016	Effect of Curcumin on Characterization and Localization of Interleukin-13 and Tumor Necrosis Factor-alpha in Liver of Diabetic Rats.	Curcumin	10-18	tumor necrosis factor	Rattus norvegicus	78-105
29906037-11	2016	The potential beneficial effects of curcumin have been shown to decline the inflammatory of liver tissue, concerning illustration of IL-13, and TNF-alpha.	Curcumin	36-44	tumor necrosis factor	Rattus norvegicus	144-153
27600540-8	2016	In addition, the levels of IL-6, IL-8 and TNF-alpha in BALF and serum of COPD rats were significantly decreased after treatment with curcumin.	Curcumin	133-141	interleukin 6	Rattus norvegicus	27-31
27600540-8	2016	In addition, the levels of IL-6, IL-8 and TNF-alpha in BALF and serum of COPD rats were significantly decreased after treatment with curcumin.	Curcumin	133-141	tumor necrosis factor	Rattus norvegicus	42-51
27600540-11	2016	Furthermore, the protein expression of p66Shc and p-p66Shc in alveolar epithelia was significantly decreased in the COPD with curcumin group compared with COPD model group.	Curcumin	126-134	SHC adaptor protein 1	Rattus norvegicus	39-45
27600540-11	2016	Furthermore, the protein expression of p66Shc and p-p66Shc in alveolar epithelia was significantly decreased in the COPD with curcumin group compared with COPD model group.	Curcumin	126-134	SHC adaptor protein 1	Rattus norvegicus	52-58
27600540-12	2016	SIGNIFICANCE: Curcumin attenuates alveolar epithelial injury in COPD rats, which may be partially due to the down-regulation of p66Shc.	Curcumin	14-22	SHC adaptor protein 1	Rattus norvegicus	128-134
27895780-5	2016	The results of cell viability, gene expression and activation of NF-kappaB and caspase 3 indicated that curcumin potentiates the anticancer effects of the aforementioned chemotherapeutic agents in the REH ALL cell line.	Curcumin	104-112	caspase 3	Homo sapiens	79-88
27895780-6	2016	Following treatment with the above chemotherapeutic agents, curcumin enhanced caspase-3 activation and downregulated nuclear factor-kappa B (NF-kappaB) activation.	Curcumin	60-68	caspase 3	Homo sapiens	78-87
27895780-0	2016	Curcumin potentiates the effect of chemotherapy against acute lymphoblastic leukemia cells via downregulation of NF-kappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	113-122
27895780-6	2016	Following treatment with the above chemotherapeutic agents, curcumin enhanced caspase-3 activation and downregulated nuclear factor-kappa B (NF-kappaB) activation.	Curcumin	60-68	nuclear factor kappa B subunit 1	Homo sapiens	117-139
27895780-5	2016	The results of cell viability, gene expression and activation of NF-kappaB and caspase 3 indicated that curcumin potentiates the anticancer effects of the aforementioned chemotherapeutic agents in the REH ALL cell line.	Curcumin	104-112	nuclear factor kappa B subunit 1	Homo sapiens	65-74
27895780-6	2016	Following treatment with the above chemotherapeutic agents, curcumin enhanced caspase-3 activation and downregulated nuclear factor-kappa B (NF-kappaB) activation.	Curcumin	60-68	nuclear factor kappa B subunit 1	Homo sapiens	141-150
27895783-0	2016	Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF-kappaB, uPA activator and MMP9.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	78-87
27895783-0	2016	Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF-kappaB, uPA activator and MMP9.	Curcumin	0-8	plasminogen activator, urokinase	Homo sapiens	89-92
27895783-3	2016	The present study investigated the hypothesis that curcumin inhibits colon cancer cell invasion by modulating NF-kappaB-mediated expression and activation of uPA and MMP9.	Curcumin	51-59	nuclear factor kappa B subunit 1	Homo sapiens	110-119
27895783-3	2016	The present study investigated the hypothesis that curcumin inhibits colon cancer cell invasion by modulating NF-kappaB-mediated expression and activation of uPA and MMP9.	Curcumin	51-59	plasminogen activator, urokinase	Homo sapiens	158-161
27895783-6	2016	In addition, curcumin activated 5" AMP-activated protein kinase (AMPK) and suppressed p65 NF-kappaB phosphorylation, as shown by western blot analysis.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	90-99
27895783-7	2016	Compound C, a potent AMPK inhibitor, abolished curcumin-induced inhibition of NF-kappaB, uPA and MMP9, suggesting that AMPK activation is responsible for curcumin-mediated NF-kappaB, uPA and MMP9 inhibition.	Curcumin	47-55	nuclear factor kappa B subunit 1	Homo sapiens	78-87
27895783-7	2016	Compound C, a potent AMPK inhibitor, abolished curcumin-induced inhibition of NF-kappaB, uPA and MMP9, suggesting that AMPK activation is responsible for curcumin-mediated NF-kappaB, uPA and MMP9 inhibition.	Curcumin	47-55	plasminogen activator, urokinase	Homo sapiens	89-92
27895783-7	2016	Compound C, a potent AMPK inhibitor, abolished curcumin-induced inhibition of NF-kappaB, uPA and MMP9, suggesting that AMPK activation is responsible for curcumin-mediated NF-kappaB, uPA and MMP9 inhibition.	Curcumin	47-55	nuclear factor kappa B subunit 1	Homo sapiens	172-181
27895783-7	2016	Compound C, a potent AMPK inhibitor, abolished curcumin-induced inhibition of NF-kappaB, uPA and MMP9, suggesting that AMPK activation is responsible for curcumin-mediated NF-kappaB, uPA and MMP9 inhibition.	Curcumin	47-55	plasminogen activator, urokinase	Homo sapiens	183-186
27895783-7	2016	Compound C, a potent AMPK inhibitor, abolished curcumin-induced inhibition of NF-kappaB, uPA and MMP9, suggesting that AMPK activation is responsible for curcumin-mediated NF-kappaB, uPA and MMP9 inhibition.	Curcumin	154-162	nuclear factor kappa B subunit 1	Homo sapiens	78-87
27895783-7	2016	Compound C, a potent AMPK inhibitor, abolished curcumin-induced inhibition of NF-kappaB, uPA and MMP9, suggesting that AMPK activation is responsible for curcumin-mediated NF-kappaB, uPA and MMP9 inhibition.	Curcumin	154-162	nuclear factor kappa B subunit 1	Homo sapiens	172-181
27895783-7	2016	Compound C, a potent AMPK inhibitor, abolished curcumin-induced inhibition of NF-kappaB, uPA and MMP9, suggesting that AMPK activation is responsible for curcumin-mediated NF-kappaB, uPA and MMP9 inhibition.	Curcumin	154-162	plasminogen activator, urokinase	Homo sapiens	183-186
27895783-8	2016	The binding activity of NF-kappaB to DNA was examined and western blotting and quantitative polymerase reaction was performed to detect the effect of curcumin on the expression of uPA and MMP9.	Curcumin	150-158	plasminogen activator, urokinase	Homo sapiens	180-183
27895783-9	2016	The present results revealed that curcumin significantly decreased the expression of uPA and MMP9 and NF-kappaB DNA binding activity.	Curcumin	34-42	plasminogen activator, urokinase	Homo sapiens	85-88
27895783-9	2016	The present results revealed that curcumin significantly decreased the expression of uPA and MMP9 and NF-kappaB DNA binding activity.	Curcumin	34-42	nuclear factor kappa B subunit 1	Homo sapiens	102-111
27895783-10	2016	Furthermore, curcumin decreased the level of the p65 subunit of NF-kappaB binding to the promoter of the gene encoding uPA and MMP9, which suppressed transcriptional activation of uPA and MMP9.	Curcumin	13-21	plasminogen activator, urokinase	Homo sapiens	119-122
27895783-10	2016	Furthermore, curcumin decreased the level of the p65 subunit of NF-kappaB binding to the promoter of the gene encoding uPA and MMP9, which suppressed transcriptional activation of uPA and MMP9.	Curcumin	13-21	plasminogen activator, urokinase	Homo sapiens	180-183
27895783-11	2016	Overall, the present data suggest that curcumin inhibits colon cancer cell invasion via AMPK activation and subsequent inhibition of p65 NF-kappaB, uPA and MMP9.	Curcumin	39-47	nuclear factor kappa B subunit 1	Homo sapiens	137-146
27514487-5	2016	Topical application of curcumin significantly inhibited acute UVB (540 mJ cm-2 , for 3 successive days)-induced inflammatory cells, collagen accrementition derangement and lipid peroxidation, and effectively induced NF-E2-related factor 2 (Nrf2) nuclear accumulation in uncovered (Uncv) hairless mice skin.	Curcumin	23-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	216-238
27514487-5	2016	Topical application of curcumin significantly inhibited acute UVB (540 mJ cm-2 , for 3 successive days)-induced inflammatory cells, collagen accrementition derangement and lipid peroxidation, and effectively induced NF-E2-related factor 2 (Nrf2) nuclear accumulation in uncovered (Uncv) hairless mice skin.	Curcumin	23-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	240-244
27895783-11	2016	Overall, the present data suggest that curcumin inhibits colon cancer cell invasion via AMPK activation and subsequent inhibition of p65 NF-kappaB, uPA and MMP9.	Curcumin	39-47	plasminogen activator, urokinase	Homo sapiens	148-151
27514487-7	2016	The photoprotective effect provided by curcumin was potential associated with modulation of Nrf2-dependent antioxidant response.	Curcumin	39-47	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
27777559-2	2016	This study aimed to assess the effects of curcumin on NLRP3 inflammasome in phorbol 12-myristate 13-acetate (PMA)-induced macrophages and explore its underlying mechanism.	Curcumin	42-50	NLR family pyrin domain containing 3	Homo sapiens	54-59
27629417-8	2016	Our results suggest that curcumin treatment induces HuR expression.	Curcumin	25-33	ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)	Mus musculus	52-55
27280688-5	2016	At the molecular and cellular level, curcumin can blunt epithelial-to-mesenchymal transition and affect many targets that are involved in melanoma initiation and progression (e.g., BCl2, MAPKS, p21 and some microRNAs).	Curcumin	37-45	BCL2 apoptosis regulator	Homo sapiens	181-185
27696400-1	2016	Retraction: "Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells" by Wang Z, Zhang Y, Banerjee S, Li Y, Sarkar FH.	Curcumin	40-48	notch receptor 1	Homo sapiens	13-20
27696400-13	2016	REFERENCES: Wang, Z., Zhang, Y., Banerjee, S., Li, Y. and Sarkar, F. H. (2006), Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells.	Curcumin	107-115	notch receptor 1	Homo sapiens	80-87
27777559-0	2016	Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-kappaB and P2X7R Signaling in PMA-Induced Macrophages.	Curcumin	0-8	NLR family pyrin domain containing 3	Homo sapiens	19-24
27629417-12	2016	Experiments with LPS-activated bone marrow-derived macrophages from wild-type and GILZ knock-out mice demonstrated that curcumin inhibits the activity of inflammatory regulators, such as NF-kappaB or ERK, and subsequent TNF-alpha production via GILZ.	Curcumin	120-128	mitogen-activated protein kinase 1	Mus musculus	200-203
27629417-12	2016	Experiments with LPS-activated bone marrow-derived macrophages from wild-type and GILZ knock-out mice demonstrated that curcumin inhibits the activity of inflammatory regulators, such as NF-kappaB or ERK, and subsequent TNF-alpha production via GILZ.	Curcumin	120-128	tumor necrosis factor	Mus musculus	220-229
27629417-13	2016	In summary, our data indicate that HuR-dependent GILZ induction contributes to the anti-inflammatory properties of curcumin.	Curcumin	115-123	ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)	Mus musculus	35-38
27626169-0	2016	The putative oncotarget CSN5 controls a transcription-uncorrelated p53-mediated autophagy implicated in cancer cell survival under curcumin treatment.	Curcumin	131-139	tumor protein p53	Homo sapiens	67-70
27626169-2	2016	The COP9 signalosome (CSN) component CSN5, a known specific target for curcumin, can control p53 stability by increasing its degradation through ubiquitin system.	Curcumin	71-79	tumor protein p53	Homo sapiens	93-96
27626169-3	2016	But the correlation of CSN5-controlled p53 to anticancer therapeutic effect of curcumin is currently unknown.	Curcumin	79-87	tumor protein p53	Homo sapiens	39-42
27626169-4	2016	Here we showed that CSN5-controlled p53 was transcriptional inactive and responsible for autophagy in human normal BJ cells and cancer HepG2 cells under curcumin treatment.	Curcumin	153-161	tumor protein p53	Homo sapiens	36-39
27626169-5	2016	Of note, CSN5-initiated cellular autophagy by curcumin treatment was abolished in p53-null HCT116p53-/- cancer cells, which could be rescued by reconstitution with wild-type p53 or transcription inactive p53 mutant p53R273H.	Curcumin	46-54	tumor protein p53	Homo sapiens	82-85
27626169-5	2016	Of note, CSN5-initiated cellular autophagy by curcumin treatment was abolished in p53-null HCT116p53-/- cancer cells, which could be rescued by reconstitution with wild-type p53 or transcription inactive p53 mutant p53R273H.	Curcumin	46-54	tumor protein p53	Homo sapiens	97-100
27626169-5	2016	Of note, CSN5-initiated cellular autophagy by curcumin treatment was abolished in p53-null HCT116p53-/- cancer cells, which could be rescued by reconstitution with wild-type p53 or transcription inactive p53 mutant p53R273H.	Curcumin	46-54	tumor protein p53	Homo sapiens	97-100
27626169-6	2016	Furthermore, CSN5-controlled p53 conferred a pro-survival autophagy in diverse cancer cells response to curcumin.	Curcumin	104-112	tumor protein p53	Homo sapiens	29-32
27626169-7	2016	Genetic p53 deletion, as well as autophagy pharmacological inhibition by chloroquine, significantly enhanced the therapeutic effect of curcumin on cancer cells in vitro and in vivo, but not normal cells.	Curcumin	135-143	tumor protein p53	Homo sapiens	8-11
27626169-9	2016	The p53 expression state is a useful biomarker for predicting the anticancer therapeutic effect of curcumin.	Curcumin	99-107	tumor protein p53	Homo sapiens	4-7
27404761-6	2016	The cells treated with 50microM of curcumin, 30.91microM (NEC-1), 20.70microM (NEC-2) and 16.86microM (NEC-3) showed enhanced activation of p53 and elevated bax/Bcl2 expression (NEC-3), increased cytochrome-c in cytosol (NEC-2) confirming the enhanced cytotoxicity.	Curcumin	35-43	tumor protein p53	Homo sapiens	140-143
27404761-6	2016	The cells treated with 50microM of curcumin, 30.91microM (NEC-1), 20.70microM (NEC-2) and 16.86microM (NEC-3) showed enhanced activation of p53 and elevated bax/Bcl2 expression (NEC-3), increased cytochrome-c in cytosol (NEC-2) confirming the enhanced cytotoxicity.	Curcumin	35-43	BCL2 associated X, apoptosis regulator	Homo sapiens	157-160
27404761-6	2016	The cells treated with 50microM of curcumin, 30.91microM (NEC-1), 20.70microM (NEC-2) and 16.86microM (NEC-3) showed enhanced activation of p53 and elevated bax/Bcl2 expression (NEC-3), increased cytochrome-c in cytosol (NEC-2) confirming the enhanced cytotoxicity.	Curcumin	35-43	BCL2 apoptosis regulator	Homo sapiens	161-165
27777559-0	2016	Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-kappaB and P2X7R Signaling in PMA-Induced Macrophages.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	64-73
27777559-5	2016	Results: Curcumin significantly reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion in PMA-induced macrophages.	Curcumin	9-17	NLR family pyrin domain containing 3	Homo sapiens	58-63
27777559-5	2016	Results: Curcumin significantly reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion in PMA-induced macrophages.	Curcumin	9-17	caspase 1	Homo sapiens	80-89
27777559-5	2016	Results: Curcumin significantly reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion in PMA-induced macrophages.	Curcumin	9-17	interleukin 1 beta	Homo sapiens	94-102
27777559-7	2016	Curcumin also markedly inhibited the upregulation of toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), phosphorylation level of IkappaB-alpha, and activation of NF-kappaB in PMA-induced macrophages.	Curcumin	0-8	NFKB inhibitor alpha	Homo sapiens	150-163
27777559-7	2016	Curcumin also markedly inhibited the upregulation of toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), phosphorylation level of IkappaB-alpha, and activation of NF-kappaB in PMA-induced macrophages.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	183-192
27777559-9	2016	Furthermore, curcumin reversed PMA-stimulated P2X7R activation, which further reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion.	Curcumin	13-21	NLR family pyrin domain containing 3	Homo sapiens	104-109
27777559-9	2016	Furthermore, curcumin reversed PMA-stimulated P2X7R activation, which further reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion.	Curcumin	13-21	caspase 1	Homo sapiens	126-135
27777559-9	2016	Furthermore, curcumin reversed PMA-stimulated P2X7R activation, which further reduced the expression of NLRP3 and cleavage of caspase-1 and IL-1beta secretion.	Curcumin	13-21	interleukin 1 beta	Homo sapiens	140-148
27777559-11	2016	Conclusion: Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA-induced macrophages.	Curcumin	12-20	NLR family pyrin domain containing 3	Homo sapiens	31-36
27777559-11	2016	Conclusion: Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA-induced macrophages.	Curcumin	12-20	nuclear factor kappa B subunit 1	Homo sapiens	81-90
27240273-1	2016	A series of novel symmetric and asymmetric allylated mono-carbonyl analogs of curcumin (MACs) were synthesized using an appropriate synthetic route and evaluated experimentally thru the LPS-induced expression of TNF-alpha and IL-6.	Curcumin	78-86	tumor necrosis factor	Rattus norvegicus	212-221
27580989-0	2016	Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	115-121
27628049-6	2016	Furthermore, we show that fenretinide or the ER stress inhibitor 4-PBA decreased curcumin-induced Glucose-regulated protein 78 (GRP78) upregulation, and produced a similar enhanced cytotoxic effect.	Curcumin	81-89	heat shock protein family A (Hsp70) member 5	Homo sapiens	98-126
27628049-6	2016	Furthermore, we show that fenretinide or the ER stress inhibitor 4-PBA decreased curcumin-induced Glucose-regulated protein 78 (GRP78) upregulation, and produced a similar enhanced cytotoxic effect.	Curcumin	81-89	heat shock protein family A (Hsp70) member 5	Homo sapiens	128-133
27628049-7	2016	In addition, GRP78 knockdown by siRNA also enhanced the cytotoxic effect of curcumin in A549 and H1299 cells.	Curcumin	76-84	heat shock protein family A (Hsp70) member 5	Homo sapiens	13-18
27580989-0	2016	Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways.	Curcumin	0-8	mitogen-activated protein kinase 9	Homo sapiens	126-130
27580989-0	2016	Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	131-134
27580989-0	2016	Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	135-139
27393927-0	2016	Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K/AKT and NF-kappaB related signaling.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	137-140
27580989-9	2016	The ERK1/2 and SAPK/JNK and their downstream molecules including P90RSK and c-Jun, respectively, were activated by curcumin.	Curcumin	115-123	mitogen-activated protein kinase 3	Homo sapiens	4-10
27393927-0	2016	Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K/AKT and NF-kappaB related signaling.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-154
27393927-6	2016	Thus, curcumin treatment attenuates LPS-induced PI3K/AKT and CYP2E/Nrf2/ROS signaling and liver injury.	Curcumin	6-14	thymoma viral proto-oncogene 1	Mus musculus	53-56
27393927-6	2016	Thus, curcumin treatment attenuates LPS-induced PI3K/AKT and CYP2E/Nrf2/ROS signaling and liver injury.	Curcumin	6-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	67-71
27580989-9	2016	The ERK1/2 and SAPK/JNK and their downstream molecules including P90RSK and c-Jun, respectively, were activated by curcumin.	Curcumin	115-123	mitogen-activated protein kinase 9	Homo sapiens	15-19
27580989-9	2016	The ERK1/2 and SAPK/JNK and their downstream molecules including P90RSK and c-Jun, respectively, were activated by curcumin.	Curcumin	115-123	mitogen-activated protein kinase 8	Homo sapiens	20-23
27580989-10	2016	Moreover, pharmacological inhibitors of ERK1/2 (U0126) and SAPK/JNK (SP600125) suppressed ERK1/2 and SAPK/JNK activation respectively, and blockage of P38 MAPK by its inhibitor (SB203580) had a synergistic effect with curcumin.	Curcumin	218-226	mitogen-activated protein kinase 3	Homo sapiens	40-46
27580989-10	2016	Moreover, pharmacological inhibitors of ERK1/2 (U0126) and SAPK/JNK (SP600125) suppressed ERK1/2 and SAPK/JNK activation respectively, and blockage of P38 MAPK by its inhibitor (SB203580) had a synergistic effect with curcumin.	Curcumin	218-226	mitogen-activated protein kinase 9	Homo sapiens	59-63
27580989-10	2016	Moreover, pharmacological inhibitors of ERK1/2 (U0126) and SAPK/JNK (SP600125) suppressed ERK1/2 and SAPK/JNK activation respectively, and blockage of P38 MAPK by its inhibitor (SB203580) had a synergistic effect with curcumin.	Curcumin	218-226	mitogen-activated protein kinase 8	Homo sapiens	64-67
27580989-10	2016	Moreover, pharmacological inhibitors of ERK1/2 (U0126) and SAPK/JNK (SP600125) suppressed ERK1/2 and SAPK/JNK activation respectively, and blockage of P38 MAPK by its inhibitor (SB203580) had a synergistic effect with curcumin.	Curcumin	218-226	mitogen-activated protein kinase 1	Homo sapiens	151-154
27580989-11	2016	These results indicate that curcumin acts as a novel chemotherapeutic agent on human placental choriocarcinoma cells via activation of ERK1/2 and SAPK/JNK signal transduction cascades.	Curcumin	28-36	mitogen-activated protein kinase 3	Homo sapiens	135-141
27580989-11	2016	These results indicate that curcumin acts as a novel chemotherapeutic agent on human placental choriocarcinoma cells via activation of ERK1/2 and SAPK/JNK signal transduction cascades.	Curcumin	28-36	mitogen-activated protein kinase 9	Homo sapiens	146-150
27580989-11	2016	These results indicate that curcumin acts as a novel chemotherapeutic agent on human placental choriocarcinoma cells via activation of ERK1/2 and SAPK/JNK signal transduction cascades.	Curcumin	28-36	mitogen-activated protein kinase 8	Homo sapiens	151-154
27497194-10	2016	Moreover, curcumin decreased the level of IL-6 in the tumor tissue and serum from LLC-bearing mice.	Curcumin	10-18	interleukin 6	Mus musculus	42-46
27424491-6	2016	Treatment with curcumin, a c-Jun inhibitor, or stable knockdown of c-Jun abrogates TGF-beta-induced Claudin-4 expression suggesting an involvement of the c-Jun pathway.	Curcumin	15-23	transforming growth factor beta 1	Homo sapiens	83-91
27424491-6	2016	Treatment with curcumin, a c-Jun inhibitor, or stable knockdown of c-Jun abrogates TGF-beta-induced Claudin-4 expression suggesting an involvement of the c-Jun pathway.	Curcumin	15-23	claudin 4	Homo sapiens	100-109
27497194-12	2016	And curcumin reduces the level of IL-6 in tumor-bearing mice to impair the expansion and function of MDSCs.	Curcumin	4-12	interleukin 6	Mus musculus	34-38
27572279-7	2016	Curcumin inhibited the osteoclastogenic potential of PBMCs, potentially by suppressing activation of extracellular signal-regulated kinases 1 and 2, p38 and c-Jun N-terminal kinase, and inhibiting receptor activator of nuclear factor kappaB (RANK), c-Fos and nuclear factor of activated T cells (NFATc1) expression.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	101-147
27572279-7	2016	Curcumin inhibited the osteoclastogenic potential of PBMCs, potentially by suppressing activation of extracellular signal-regulated kinases 1 and 2, p38 and c-Jun N-terminal kinase, and inhibiting receptor activator of nuclear factor kappaB (RANK), c-Fos and nuclear factor of activated T cells (NFATc1) expression.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	149-152
27297718-10	2016	CONCLUSIONS: Curcumin can improve serum levels of adiponectin and leptin in patients with metabolic syndrome.	Curcumin	13-21	adiponectin, C1Q and collagen domain containing	Homo sapiens	50-61
27572503-0	2016	Curcumin inhibits H2O2-induced invasion and migration of human pancreatic cancer via suppression of the ERK/NF-kappaB pathway.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	104-107
27572503-0	2016	Curcumin inhibits H2O2-induced invasion and migration of human pancreatic cancer via suppression of the ERK/NF-kappaB pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	108-117
27572503-13	2016	In addition, the H2O2-induced elevation of p-ERK and p-NF-kappaB in BxPC-3 and Panc-1 cells were reduced by curcumin, NAC and PD 98059 (an ERK inhibitor).	Curcumin	108-116	nuclear factor kappa B subunit 1	Homo sapiens	55-64
27829747-0	2016	Evaluation of superoxide dismutase levels in local drug delivery system containing 0.2% curcumin strip as an adjunct to scaling and root planing in chronic periodontitis: A clinical and biochemical study.	Curcumin	88-96	superoxide dismutase 1	Homo sapiens	14-34
27572503-13	2016	In addition, the H2O2-induced elevation of p-ERK and p-NF-kappaB in BxPC-3 and Panc-1 cells were reduced by curcumin, NAC and PD 98059 (an ERK inhibitor).	Curcumin	108-116	mitogen-activated protein kinase 1	Homo sapiens	45-48
27572503-14	2016	These data indicate that curcumin suppresses pancreatic cancer migration and invasion through the inhibition of the ROS/ERK/NF-kappaB signaling pathway.	Curcumin	25-33	mitogen-activated protein kinase 1	Homo sapiens	120-123
27572503-14	2016	These data indicate that curcumin suppresses pancreatic cancer migration and invasion through the inhibition of the ROS/ERK/NF-kappaB signaling pathway.	Curcumin	25-33	nuclear factor kappa B subunit 1	Homo sapiens	124-133
27468716-4	2016	In particular, extensive studies have demonstrated that curcumin targets numerous therapeutically important cancer signaling pathways such as p53, Ras, PI3K, AKT, Wnt-beta catenin, mTOR and so on.	Curcumin	56-64	tumor protein p53	Homo sapiens	142-145
26911246-0	2016	Curcumin induced apoptosis via PI3K/Akt-signalling pathways in SKOV3 cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	36-39
26911246-5	2016	Results The administration of curcumin (0, 20, 30 and 40 muM) inhibits SKOV3 cell growth (IC50  value= 24.8 muM) and increased apoptosis (32.5 and 85.7%).	Curcumin	30-38	latexin	Homo sapiens	57-60
26911246-5	2016	Results The administration of curcumin (0, 20, 30 and 40 muM) inhibits SKOV3 cell growth (IC50  value= 24.8 muM) and increased apoptosis (32.5 and 85.7%).	Curcumin	30-38	latexin	Homo sapiens	108-111
26911246-7	2016	Results of western blot analysis confirmed that the expression of p-Akt protein was decreased by curcumin (p &lt; 0.05).	Curcumin	97-105	AKT serine/threonine kinase 1	Homo sapiens	68-71
26911246-8	2016	It was also found that a high dose of curcumin (40 muM) can cause stronger antitumour activity (80.4%).	Curcumin	38-46	latexin	Homo sapiens	51-54
26911246-9	2016	Conclusion Our results suggest that the curcumin induced SKOV3 apoptosis via modulation of the PI3K/Akt-signalling pathway.	Curcumin	40-48	AKT serine/threonine kinase 1	Homo sapiens	100-103
27456358-1	2016	In this work, the in vitro experiments about biological mechanisms of curcumin were conducted using the gastric cancer cell lines SGC-7901 and BGC-823.	Curcumin	70-78	sarcoglycan beta	Homo sapiens	130-133
27456358-5	2016	Next, curcumin was also identified to regulate the proliferation and apoptosis of SGC-7901 and BGC-823 cells.	Curcumin	6-14	sarcoglycan beta	Homo sapiens	82-85
27297718-1	2016	OBJECTIVE: Previous experimental studies have suggested curcumin as a safe phytochemical that can improve insulin resistance through effects on adiponectin and leptin.	Curcumin	56-64	adiponectin, C1Q and collagen domain containing	Homo sapiens	144-155
27297718-2	2016	This study aimed to investigate the effect of curcumin on circulating adiponectin and leptin concentrations in patients with metabolic syndrome.	Curcumin	46-54	adiponectin, C1Q and collagen domain containing	Homo sapiens	70-81
27297718-5	2016	The pooled effect size for the impact of curcumin supplementation on serum adiponectin and leptin levels was also estimated using random-effects metaanalysis.	Curcumin	41-49	adiponectin, C1Q and collagen domain containing	Homo sapiens	75-86
27297718-6	2016	RESULTS: Eight-week supplementation with curcumin was associated with a significant increase in serum adiponectin levels (P &lt; 0.001) and a reduction in serum leptin concentrations (P &lt; 0.001).	Curcumin	41-49	adiponectin, C1Q and collagen domain containing	Homo sapiens	102-113
27297718-7	2016	Serum leptin:adiponectin ratio was also improved by curcumin (P &lt; 0.001).	Curcumin	52-60	adiponectin, C1Q and collagen domain containing	Homo sapiens	13-24
27297718-9	2016	Metaanalysis suggested that curcumin supplementation can increase adiponectin levels by 76.78% (95% CI: 6.14-147.42; P = 0.0330), and reduce leptin by 26.49% (95% CI: -70.44 to 17.46), however this latter effect size did not reach statistical significance (P = 0.238).	Curcumin	28-36	adiponectin, C1Q and collagen domain containing	Homo sapiens	66-77
27456358-10	2016	Collectively, our results indicate that curcumin-miR-33b-XIAP coupling might be an important mechanism by which curcumin induces the apoptosis of SGC-7901 and BGC-823 cells.	Curcumin	40-48	sarcoglycan beta	Homo sapiens	146-149
27456358-10	2016	Collectively, our results indicate that curcumin-miR-33b-XIAP coupling might be an important mechanism by which curcumin induces the apoptosis of SGC-7901 and BGC-823 cells.	Curcumin	112-120	sarcoglycan beta	Homo sapiens	146-149
27468716-4	2016	In particular, extensive studies have demonstrated that curcumin targets numerous therapeutically important cancer signaling pathways such as p53, Ras, PI3K, AKT, Wnt-beta catenin, mTOR and so on.	Curcumin	56-64	AKT serine/threonine kinase 1	Homo sapiens	158-161
27468716-4	2016	In particular, extensive studies have demonstrated that curcumin targets numerous therapeutically important cancer signaling pathways such as p53, Ras, PI3K, AKT, Wnt-beta catenin, mTOR and so on.	Curcumin	56-64	mechanistic target of rapamycin kinase	Homo sapiens	181-185
27564099-0	2016	Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROS-mediated activation of ERK1/2.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	113-119
27680947-9	2016	RESULTS: Circadian rhythms in cell death were observed in response to low (5 muM) curcumin, reaching a peak several hours before the peak in rhythmic expression of mPER2 protein, a major circadian clock component.	Curcumin	82-90	latexin	Homo sapiens	77-80
27564099-3	2016	We found that curcumin and cisplatin co-treatment primarily targets reactive oxygen species(ROS) and extracellular regulated kinase(ERK) signaling during the apoptosis induction in bladder cancer.	Curcumin	14-22	mitogen-activated protein kinase 1	Homo sapiens	132-135
27564099-9	2016	Moreover, pretreatment with U0126 suppressed curcumin and cisplatin-induced upregulation of p53, p21, and p-STAT3 and downregulation of survival proteins in both cells.	Curcumin	45-53	tumor protein p53	Homo sapiens	92-95
27564099-9	2016	Moreover, pretreatment with U0126 suppressed curcumin and cisplatin-induced upregulation of p53, p21, and p-STAT3 and downregulation of survival proteins in both cells.	Curcumin	45-53	signal transducer and activator of transcription 3	Homo sapiens	108-113
27564099-10	2016	In conclusion, co-treatment with curcumin and cisplatin synergistically induced apoptosis through ROS-mediated activation of ERK1/2 in bladder cancer.	Curcumin	33-41	mitogen-activated protein kinase 3	Homo sapiens	125-131
27564099-5	2016	Also, caspase-3 activation and ROS production were observed in both cells treated with curcumin and cisplatin, together with upregulation of p-MEK and p-ERK1/2 signaling.	Curcumin	87-95	caspase 3	Homo sapiens	6-15
27564099-5	2016	Also, caspase-3 activation and ROS production were observed in both cells treated with curcumin and cisplatin, together with upregulation of p-MEK and p-ERK1/2 signaling.	Curcumin	87-95	mitogen-activated protein kinase 3	Homo sapiens	153-159
27564099-6	2016	NAC(ROS scavenger) and U0126(ERK inhibitor) inhibited apoptosis induced by curcumin and cisplatin.	Curcumin	75-83	mitogen-activated protein kinase 1	Homo sapiens	29-32
27564099-7	2016	In addition, when 253J-Bv cells were co-treated with curcumin and cisplatin, p53 and p21 expression levels were markedly increased when compared to controls.	Curcumin	53-61	tumor protein p53	Homo sapiens	77-80
27564099-8	2016	Unlike 253J-Bv cells, T24 cells were co-treated with curcumin and cisplatin revealed an induction of apoptosis through decreased p-signal transducer and activator of transcription 3(STAT3) expression.	Curcumin	53-61	signal transducer and activator of transcription 3	Homo sapiens	182-187
27568287-0	2016	SIRT1-mediated deacetylation of PGC1alpha attributes to the protection of curcumin against glutamate excitotoxicity in cortical neurons.	Curcumin	74-82	PPARG coactivator 1 alpha	Homo sapiens	32-41
27568287-4	2016	In this study, we explored whether the silent information regulator 1 (SIRT1)-peroxisome proliferator-activated receptor-coactivator 1alpha (PGC1alpha) pathway participated in the protection of curcumin against glutamate excitotoxicity.	Curcumin	194-202	PPARG coactivator 1 alpha	Homo sapiens	141-150
27568287-9	2016	Meanwhile, curcumin preserved mitochondrial function, increased the expression level of SIRT1 and reduced the level of ac-PGC1alpha in the presence of glutamate.	Curcumin	11-19	PPARG coactivator 1 alpha	Homo sapiens	122-131
27568287-10	2016	These results suggest that SIRT1-mediated deacetylation of PGC1alpha attributes to the neuroprotection of curcumin against glutamate excitotoxicity.	Curcumin	106-114	PPARG coactivator 1 alpha	Homo sapiens	59-68
27373979-0	2016	Cathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells.	Curcumin	31-39	cathepsin L	Homo sapiens	0-11
27624003-5	2016	Curcumin, one major compound derived from DNT, exerted the protective effect against cholestasis through farnesoid X receptor (FXR), which has been focused as potential therapeutic targets for treating cholestasis.	Curcumin	0-8	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	115-125
27461789-4	2016	The objective of the present study was to give more insight into the binding of curcumin analogues, curcuminoids, to Abeta containing plaques in postmortem tissue from AD patients.	Curcumin	80-88	amyloid beta precursor protein	Homo sapiens	117-122
27461789-8	2016	These findings suggest that curcumin analogues, especially BDMC, may serve as a potential radioligands for Abeta plaque neuroimaging.	Curcumin	28-36	amyloid beta precursor protein	Homo sapiens	107-112
27373979-4	2016	This study aimed to determine the role of cathepsin L in curcumin-mediated inhibition of growth, migration, and invasion of glioma cells.	Curcumin	57-65	cathepsin L	Homo sapiens	42-53
27373979-5	2016	Results revealed that the activity of cathepsin L was enhanced in curcumin-treated glioma cells.	Curcumin	66-74	cathepsin L	Homo sapiens	38-49
27373979-6	2016	Cathepsin L knockdown induced by RNA interference significantly promoted curcumin-induced cytotoxicity, apoptosis, and cell cycle arrest.	Curcumin	73-81	cathepsin L	Homo sapiens	0-11
27373979-8	2016	Our results suggested that the inhibition of cathepsin L can enhance the sensitivity of glioma cells to curcumin.	Curcumin	104-112	cathepsin L	Homo sapiens	45-56
27373979-9	2016	Therefore, cathepsin L may be a new target to enhance the efficacy of curcumin against cancers.	Curcumin	70-78	cathepsin L	Homo sapiens	11-22
27194344-6	2016	In response to TNF-alpha (25 ng ml(-1))-induced protein degradation, EPA had a small, but not significant effect on protein degradation; however, when curcumin and GTE were combined with EPA, the effect was enhanced.	Curcumin	151-159	tumor necrosis factor	Homo sapiens	15-24
27375190-0	2016	Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation of Nrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
27375190-6	2016	Meanwhile, curcumin pretreatment markedly down-regulated the expression of nuclear factor -kB (NF-kB) and iNOS mRNAs, but up-regulated the expressions of Nrf2 and HO-1 mRNAs, compared to the QCT alone group.	Curcumin	11-19	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
27375190-8	2016	These results indicate that curcumin could effectively inhibit QCT induced apoptosis and inflammatory response in L02 cells, which may involve the activation of Nrf2/HO-1 and inhibition of NF-kB pathway.	Curcumin	28-36	NFE2 like bZIP transcription factor 2	Homo sapiens	161-165
27194344-10	2016	Both TNF-alpha and PIF significantly reduced myotube diameter from 17 to 13 mum for TNF-alpha (23.5%) and 15 mum (11.8%) for PIF However the triple combination of EPA, curcumin and GTE returned diameters to values not significantly different from the control.	Curcumin	168-176	tumor necrosis factor	Homo sapiens	5-14
27573203-7	2016	Results showed that curcumin decreased E-cadherin, N-cadherin, beta-catenin, Slug, AXL, Twist1, Vimentin and Fibronectin protein expression, independently of the positivity of the markers in the cell lines.	Curcumin	20-28	cadherin 1	Mus musculus	39-49
27432244-0	2016	Curcumin exerts antitumor effects in retinoblastoma cells by regulating the JNK and p38 MAPK pathways.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	76-79
27432244-0	2016	Curcumin exerts antitumor effects in retinoblastoma cells by regulating the JNK and p38 MAPK pathways.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	84-87
27432244-5	2016	Curcumin induced G1 phase arrest through downregulating the expression of cyclin D3 and cyclin-dependent kinase (CDK)2/6 and upregulating the expression of CDK inhibitor proteins p21 and p27.	Curcumin	0-8	cyclin D3	Homo sapiens	74-83
27233000-3	2016	Western blot presented that the protein expression of iNOS can be reduced by curcumin.	Curcumin	77-85	nitric oxide synthase 2, inducible	Mus musculus	54-58
27573203-7	2016	Results showed that curcumin decreased E-cadherin, N-cadherin, beta-catenin, Slug, AXL, Twist1, Vimentin and Fibronectin protein expression, independently of the positivity of the markers in the cell lines.	Curcumin	20-28	snail family zinc finger 2	Mus musculus	77-81
27432244-8	2016	We also found that curcumin induced the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK).	Curcumin	19-27	mitogen-activated protein kinase 8	Homo sapiens	59-82
27432244-8	2016	We also found that curcumin induced the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK).	Curcumin	19-27	mitogen-activated protein kinase 8	Homo sapiens	84-87
27160424-5	2016	Genistein and curcumin also enhanced forskolin-induced swelling of F508del homozygous organoids that were treated with VX-770 and the prototypical CFTR corrector VX-809.	Curcumin	14-22	CF transmembrane conductance regulator	Homo sapiens	147-151
27432244-8	2016	We also found that curcumin induced the phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK).	Curcumin	19-27	mitogen-activated protein kinase 14	Homo sapiens	93-129
27432244-9	2016	JNK and p38 MAPK inhibitors significantly suppressed curcumin-induced activation of caspases-9/-3 and inhibited the apoptosis of Y79 cells.	Curcumin	53-61	mitogen-activated protein kinase 8	Homo sapiens	0-3
27432244-9	2016	JNK and p38 MAPK inhibitors significantly suppressed curcumin-induced activation of caspases-9/-3 and inhibited the apoptosis of Y79 cells.	Curcumin	53-61	mitogen-activated protein kinase 14	Homo sapiens	8-11
27432244-10	2016	Taken together, our results suggest that curcumin induced the apoptosis of Y79 cells through the activation of JNK and p38 MAPK pathways.	Curcumin	41-49	mitogen-activated protein kinase 8	Homo sapiens	111-114
27432244-10	2016	Taken together, our results suggest that curcumin induced the apoptosis of Y79 cells through the activation of JNK and p38 MAPK pathways.	Curcumin	41-49	mitogen-activated protein kinase 14	Homo sapiens	119-122
27160424-6	2016	These results indicate that VX-770, genistein and curcumin in double or triple combinations can synergize in restoring CFTR-dependent fluid secretion in primary CF cells and support the use of multiple potentiators for treatment of CF.	Curcumin	50-58	CF transmembrane conductance regulator	Homo sapiens	119-123
27160424-3	2016	We have recently pioneered a functional CFTR assay in primary rectal organoids and used this model to characterize interactions between VX-770, genistein and curcumin, the latter 2 being natural food components with established CFTR potentiation capacities.	Curcumin	158-166	CF transmembrane conductance regulator	Homo sapiens	228-232
27160424-4	2016	Results indicated that all possible combinations of VX-770, genistein and curcumin synergistically repaired CFTR-dependent forskolin-induced swelling of organoids with CFTR-S1251N or CFTR-G551D, even under suboptimal CFTR activation and compounds concentrations, conditions that may predominate in vivo.	Curcumin	74-82	CF transmembrane conductance regulator	Homo sapiens	108-112
27160424-4	2016	Results indicated that all possible combinations of VX-770, genistein and curcumin synergistically repaired CFTR-dependent forskolin-induced swelling of organoids with CFTR-S1251N or CFTR-G551D, even under suboptimal CFTR activation and compounds concentrations, conditions that may predominate in vivo.	Curcumin	74-82	CF transmembrane conductance regulator	Homo sapiens	168-172
27160424-4	2016	Results indicated that all possible combinations of VX-770, genistein and curcumin synergistically repaired CFTR-dependent forskolin-induced swelling of organoids with CFTR-S1251N or CFTR-G551D, even under suboptimal CFTR activation and compounds concentrations, conditions that may predominate in vivo.	Curcumin	74-82	CF transmembrane conductance regulator	Homo sapiens	168-172
26988571-0	2016	A gallium(III) Schiff base-curcumin complex that binds to amyloid-beta plaques.	Curcumin	27-35	amyloid beta precursor protein	Homo sapiens	58-70
27160424-4	2016	Results indicated that all possible combinations of VX-770, genistein and curcumin synergistically repaired CFTR-dependent forskolin-induced swelling of organoids with CFTR-S1251N or CFTR-G551D, even under suboptimal CFTR activation and compounds concentrations, conditions that may predominate in vivo.	Curcumin	74-82	CF transmembrane conductance regulator	Homo sapiens	168-172
27505300-6	2016	Treatment of gamma-irradiated rats with the new curcumin analogues (2-7) showed significant amelioration in the in-vivo antioxidant status, liver and kidney functions, as well as the anti-inflammatory markers (IL-6, TNF-alpha and NF-kappaB).	Curcumin	48-56	interleukin 6	Rattus norvegicus	210-214
27505300-6	2016	Treatment of gamma-irradiated rats with the new curcumin analogues (2-7) showed significant amelioration in the in-vivo antioxidant status, liver and kidney functions, as well as the anti-inflammatory markers (IL-6, TNF-alpha and NF-kappaB).	Curcumin	48-56	tumor necrosis factor	Rattus norvegicus	216-225
27392742-0	2016	Effect of curcumin on circulating interleukin-6 concentrations: A systematic review and meta-analysis of randomized controlled trials.	Curcumin	10-18	interleukin 6	Homo sapiens	34-47
27502306-7	2016	Similarly, ALP activity and expression of bone-related molecules including Runx2, BMP2, and Osterix were also decreased in VSMCs treated with curcumin.	Curcumin	142-150	RUNX family transcription factor 2	Rattus norvegicus	75-80
27233246-0	2016	Curcumin Attenuated Bupivacaine-Induced Neurotoxicity in SH-SY5Y Cells Via Activation of the Akt Signaling Pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	93-96
27233246-9	2016	Interestingly, the curcumin treatment increased the levels of Akt phosphorylation.	Curcumin	19-27	AKT serine/threonine kinase 1	Homo sapiens	62-65
27233246-10	2016	More significantly, the pharmacological inhibition of Akt abolished the cytoprotective effect of curcumin against bupivacaine-induced cell injury.	Curcumin	97-105	AKT serine/threonine kinase 1	Homo sapiens	54-57
27233246-11	2016	Our data suggest that pretreating SH-SY5Y cells with curcumin provides a protective effect on bupivacaine-induced neuronal injury via activation of the Akt signaling pathway.	Curcumin	53-61	AKT serine/threonine kinase 1	Homo sapiens	152-155
27392742-6	2016	There was a significant association between the IL-6-lowering activity of curcumin and baseline IL-6 concentration (slope: -0.51; 95% CI: -0.80, -0.23; p=0.005).	Curcumin	74-82	interleukin 6	Homo sapiens	48-52
27392742-6	2016	There was a significant association between the IL-6-lowering activity of curcumin and baseline IL-6 concentration (slope: -0.51; 95% CI: -0.80, -0.23; p=0.005).	Curcumin	74-82	interleukin 6	Homo sapiens	96-100
27392742-7	2016	This meta-analysis of RCTs suggested a significant effect of curcumin in lowering circulating IL-6 concentrations.	Curcumin	61-69	interleukin 6	Homo sapiens	94-98
27197667-5	2016	In addition, curcumin markedly increased activities of radical scavenging enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase in a dose-dependent manner.	Curcumin	13-21	catalase	Rattus norvegicus	119-127
27556439-4	2016	The results showed that curcumin pre-treatment significantly ameliorated FZD-induced oxidative stress, characterized by decreased reactive oxygen species (ROS) and malondialdehyde formation, and increased superoxide dismutase, catalase activities and glutathione contents.	Curcumin	24-32	catalase	Homo sapiens	227-235
27621662-0	2016	Curcumin prevents muscle damage by regulating NF-kappaB and Nrf2 pathways and improves performance: an in vivo model.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	60-64
27561811-3	2016	We hypothesized that turmeric extract and curcumin protect the liver from CCl4-induced liver injury by reducing oxidative stress, inhibiting lipid peroxidation, and increasing glutathione peroxidase activation.	Curcumin	42-50	C-C motif chemokine ligand 4	Rattus norvegicus	74-78
27561811-8	2016	CONCLUSIONS: Our data suggest that turmeric extract and curcumin protect the liver from chronic CCl4-induced injury in rats by suppressing hepatic oxidative stress.	Curcumin	56-64	C-C motif chemokine ligand 4	Rattus norvegicus	96-100
27561811-0	2016	Turmeric extract and its active compound, curcumin, protect against chronic CCl4-induced liver damage by enhancing antioxidation.	Curcumin	42-50	C-C motif chemokine ligand 4	Rattus norvegicus	76-80
27561811-2	2016	Here, we investigated the mechanism by which turmeric and curcumin protect the liver against carbon tetrachloride (CCl4)-induced injury in rats.	Curcumin	58-66	C-C motif chemokine ligand 4	Rattus norvegicus	115-119
27556439-7	2016	Curcumin pre-treatment consistently and markedly down-regulated the mRNA expression levels of p53, Bax, caspase-9 and -3 and up-regulated the mRNA expression level of Bcl-2.	Curcumin	0-8	tumor protein p53	Homo sapiens	94-97
27556439-7	2016	Curcumin pre-treatment consistently and markedly down-regulated the mRNA expression levels of p53, Bax, caspase-9 and -3 and up-regulated the mRNA expression level of Bcl-2.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	99-102
27556439-7	2016	Curcumin pre-treatment consistently and markedly down-regulated the mRNA expression levels of p53, Bax, caspase-9 and -3 and up-regulated the mRNA expression level of Bcl-2.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	167-172
27318188-0	2016	Modulation of P-glycoprotein activity by novel synthetic curcumin derivatives in sensitive and multidrug-resistant T-cell acute lymphoblastic leukemia cell lines.	Curcumin	57-65	ATP binding cassette subfamily B member 1	Homo sapiens	14-28
27172265-5	2016	In this study, a synthesized curcumin derivative termed C1 is identified as a novel MTOR-independent activator of TFEB.	Curcumin	29-37	mechanistic target of rapamycin kinase	Homo sapiens	84-88
27551266-8	2016	Curcumin-resveratrol co-treatment decreased Bax/Bcl2 ratio, mitochondria to cytosolic translocation of cytochrome c and activated the survival protein Akt.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	48-52
27551266-8	2016	Curcumin-resveratrol co-treatment decreased Bax/Bcl2 ratio, mitochondria to cytosolic translocation of cytochrome c and activated the survival protein Akt.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	151-154
27551266-9	2016	Curcumin-resveratrol decreased the expression of p53 dependent apoptotic genes like Fas, FasL, Bax, Bcl2, and Apaf1.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	100-104
27525306-0	2016	Curcumin inhibited HGF-induced EMT and angiogenesis through regulating c-Met dependent PI3K/Akt/mTOR signaling pathways in lung cancer.	Curcumin	0-8	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	71-76
27525306-0	2016	Curcumin inhibited HGF-induced EMT and angiogenesis through regulating c-Met dependent PI3K/Akt/mTOR signaling pathways in lung cancer.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	92-95
27525306-0	2016	Curcumin inhibited HGF-induced EMT and angiogenesis through regulating c-Met dependent PI3K/Akt/mTOR signaling pathways in lung cancer.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	96-100
27525306-5	2016	Moreover, pretreatment with curcumin blocked HGF-induced c-Met phosphorylation and downstream activation of Akt, mTOR, and S6.	Curcumin	28-36	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	57-62
27525306-5	2016	Moreover, pretreatment with curcumin blocked HGF-induced c-Met phosphorylation and downstream activation of Akt, mTOR, and S6.	Curcumin	28-36	AKT serine/threonine kinase 1	Homo sapiens	108-111
27525306-5	2016	Moreover, pretreatment with curcumin blocked HGF-induced c-Met phosphorylation and downstream activation of Akt, mTOR, and S6.	Curcumin	28-36	mechanistic target of rapamycin kinase	Homo sapiens	113-117
27525306-7	2016	c-Met gene overexpression analysis further demonstrated that curcumin suppressed lung cancer cell EMT by inhibiting c-Met/Akt/mTOR signaling pathways.	Curcumin	61-69	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	0-5
27525306-7	2016	c-Met gene overexpression analysis further demonstrated that curcumin suppressed lung cancer cell EMT by inhibiting c-Met/Akt/mTOR signaling pathways.	Curcumin	61-69	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	116-121
27525306-7	2016	c-Met gene overexpression analysis further demonstrated that curcumin suppressed lung cancer cell EMT by inhibiting c-Met/Akt/mTOR signaling pathways.	Curcumin	61-69	AKT serine/threonine kinase 1	Homo sapiens	122-125
27525306-7	2016	c-Met gene overexpression analysis further demonstrated that curcumin suppressed lung cancer cell EMT by inhibiting c-Met/Akt/mTOR signaling pathways.	Curcumin	61-69	mechanistic target of rapamycin kinase	Homo sapiens	126-130
27525306-8	2016	In human umbilical vein endothelial cells (HUVECs), we found that curcumin also significantly inhibited PI3K/Akt/mTOR signaling and induced apoptosis and reduced migration and tube formation of HGF-treated HUVEC.	Curcumin	66-74	AKT serine/threonine kinase 1	Homo sapiens	109-112
27525306-8	2016	In human umbilical vein endothelial cells (HUVECs), we found that curcumin also significantly inhibited PI3K/Akt/mTOR signaling and induced apoptosis and reduced migration and tube formation of HGF-treated HUVEC.	Curcumin	66-74	mechanistic target of rapamycin kinase	Homo sapiens	113-117
27525306-9	2016	Finally, in the experimental mouse model, we showed that curcumin inhibited HGF-stimulated tumor growth and induced an increase in E-cadherin expression and a decrease in vimentin, CD34, and vascular endothelial growth factor (VEGF) expression.	Curcumin	57-65	cadherin 1	Mus musculus	131-141
27525306-10	2016	Collectively, these findings indicated that curcumin could inhibit HGF-promoted EMT and angiogenesis by targeting c-Met and blocking PI3K/Akt/mTOR pathways.	Curcumin	44-52	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	114-119
27525306-10	2016	Collectively, these findings indicated that curcumin could inhibit HGF-promoted EMT and angiogenesis by targeting c-Met and blocking PI3K/Akt/mTOR pathways.	Curcumin	44-52	AKT serine/threonine kinase 1	Homo sapiens	138-141
27525306-10	2016	Collectively, these findings indicated that curcumin could inhibit HGF-promoted EMT and angiogenesis by targeting c-Met and blocking PI3K/Akt/mTOR pathways.	Curcumin	44-52	mechanistic target of rapamycin kinase	Homo sapiens	142-146
27132804-0	2016	Sensitization of androgen refractory prostate cancer cells to anti-androgens through re-expression of epigenetically repressed androgen receptor - Synergistic action of quercetin and curcumin.	Curcumin	183-191	androgen receptor	Homo sapiens	127-144
27132804-2	2016	Some dietary phytocompounds like quercetin (Q) and curcumin (C) with reported DNMT-inhibitory activity were tested for their ability to re-express the AR in AR-negative CaP cell lines PC3 and DU145.	Curcumin	51-59	androgen receptor	Homo sapiens	151-153
27267893-2	2016	We investigated the effectiveness of curcumin, a potent inhibitor of NF-kappaB/COX-2, molecules perturbed in oral carcinogenesis, to treat leukoplakia.	Curcumin	37-45	nuclear factor kappa B subunit 1	Homo sapiens	69-78
27470399-6	2016	Within-group analysis revealed significant reductions in serum concentrations of TNF-alpha, IL-6, TGF-beta and MCP-1 following curcumin supplementation (p&lt;0.001).	Curcumin	127-135	tumor necrosis factor	Homo sapiens	81-90
27470399-6	2016	Within-group analysis revealed significant reductions in serum concentrations of TNF-alpha, IL-6, TGF-beta and MCP-1 following curcumin supplementation (p&lt;0.001).	Curcumin	127-135	interleukin 6	Homo sapiens	92-96
27470399-6	2016	Within-group analysis revealed significant reductions in serum concentrations of TNF-alpha, IL-6, TGF-beta and MCP-1 following curcumin supplementation (p&lt;0.001).	Curcumin	127-135	transforming growth factor beta 1	Homo sapiens	98-106
27470399-8	2016	Between-group comparison suggested significantly greater reductions in serum concentrations of TNF-alpha, IL-6, TGF-beta and MCP-1 in the curcumin versus placebo group (p&lt;0.001).	Curcumin	138-146	tumor necrosis factor	Homo sapiens	95-104
27470399-8	2016	Between-group comparison suggested significantly greater reductions in serum concentrations of TNF-alpha, IL-6, TGF-beta and MCP-1 in the curcumin versus placebo group (p&lt;0.001).	Curcumin	138-146	interleukin 6	Homo sapiens	106-110
27470399-8	2016	Between-group comparison suggested significantly greater reductions in serum concentrations of TNF-alpha, IL-6, TGF-beta and MCP-1 in the curcumin versus placebo group (p&lt;0.001).	Curcumin	138-146	transforming growth factor beta 1	Homo sapiens	112-120
27267893-2	2016	We investigated the effectiveness of curcumin, a potent inhibitor of NF-kappaB/COX-2, molecules perturbed in oral carcinogenesis, to treat leukoplakia.	Curcumin	37-45	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84
27446282-7	2016	Extracellular HSP60 is a ligand of Toll-like receptor 4 (TLR-4), and the level of the latter was increased in the LPS-activated BV2 microglia and inhibited by curcumin.	Curcumin	159-167	toll-like receptor 4	Mus musculus	35-55
27515884-0	2016	Successful treatment of c-kit-positive metastatic Adenoid Cystic Carcinoma (ACC) with a combination of curcumin plus imatinib: A case report.	Curcumin	103-111	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	24-29
27515884-7	2016	Curcumin has been shown to inhibit NF-kappaB and NF-kappaB-related pathways.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	35-44
27515884-7	2016	Curcumin has been shown to inhibit NF-kappaB and NF-kappaB-related pathways.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	49-58
27515884-15	2016	To our knowledge, this is the first report of a patient with a c-kit-positive ACC that is successfully treated with the combination of imatinib and curcumin in an integrative approach.	Curcumin	148-156	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	63-68
27203664-8	2016	Renal protein expression of extracellular signal-regulated kinase (ERK)1/2 and nuclear factor (NF)kappaB p65 were increased in DNR treated rats, and treatment with curcumin attenuated these increased expression.	Curcumin	164-172	synaptotagmin 1	Rattus norvegicus	105-108
27452633-0	2016	Pharmacokinetic effects of curcumin on docetaxel mediated by OATP1B1, OATP1B3 and CYP450s.	Curcumin	27-35	solute carrier organic anion transporter family member 1B3	Homo sapiens	70-77
27452633-5	2016	Human embryonic kidney 293 (HEK293) cells stably expressing OATP1B1 and OATP1B3 were used to observe the effects of curcumin on OATP1B1 and OATP1B3-mediated uptake of docetaxel.	Curcumin	116-124	solute carrier organic anion transporter family member 1B3	Homo sapiens	140-147
27452633-6	2016	Curcumin exhibited potent inhibition on OATP1B1 and OATP1B3-mediated docetaxel uptake with IC50 values of 3.81 +- 1.19 muM and 33.70 +- 1.22 muM, respectively.	Curcumin	0-8	solute carrier organic anion transporter family member 1B3	Homo sapiens	52-59
27452633-8	2016	The preclinical and clinical improved docetaxel"s therapeutic efficacy when co-administrated with curcumin may be due to the inhibition of curcumin on OATP1B1, OATP1B3 and HLMs activities.	Curcumin	98-106	solute carrier organic anion transporter family member 1B3	Homo sapiens	160-167
27452633-8	2016	The preclinical and clinical improved docetaxel"s therapeutic efficacy when co-administrated with curcumin may be due to the inhibition of curcumin on OATP1B1, OATP1B3 and HLMs activities.	Curcumin	139-147	solute carrier organic anion transporter family member 1B3	Homo sapiens	160-167
27446282-7	2016	Extracellular HSP60 is a ligand of Toll-like receptor 4 (TLR-4), and the level of the latter was increased in the LPS-activated BV2 microglia and inhibited by curcumin.	Curcumin	159-167	toll-like receptor 4	Mus musculus	57-62
27446282-9	2016	In the present study, curcumin demonstrated marked suppression of the LPS-induced expression of MyD88, NF-kappaB, caspase-3, inducible nitric oxide synthase, tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 in the microglia.	Curcumin	22-30	interleukin 1 beta	Mus musculus	187-209
27446282-9	2016	In the present study, curcumin demonstrated marked suppression of the LPS-induced expression of MyD88, NF-kappaB, caspase-3, inducible nitric oxide synthase, tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 in the microglia.	Curcumin	22-30	interleukin 6	Mus musculus	214-218
27446282-10	2016	These results indicate that curcumin may exert its neuroprotective and anti-inflammatory effects by inhibiting microglial activation through the HSP60/TLR-4/MyD88/NF-kappaB signaling wpathway.	Curcumin	28-36	toll-like receptor 4	Mus musculus	151-156
26299635-0	2016	Combinatorial anticancer effects of curcumin and sorafenib towards thyroid cancer cells via PI3K/Akt and ERK pathways.	Curcumin	36-44	AKT serine/threonine kinase 1	Homo sapiens	97-100
26608462-10	2016	Caspase-3 activity was lower in the curcumin group than in the H2O2 group.	Curcumin	36-44	caspase 3	Homo sapiens	0-9
26608462-11	2016	In conclusion, curcumin strongly induced modulator effects on oxidative stress, intracellular Ca(2+) levels, and the caspase-3 and -9 values in an experimental oxidative stress model in SH-SY5Y cells.	Curcumin	15-23	caspase 3	Homo sapiens	117-133
26299635-2	2016	The present results demonstrated that curcumin at 15-25 muM dose-dependently suppressed the proliferation of FTC133.	Curcumin	38-46	latexin	Homo sapiens	56-59
26299635-3	2016	Combined treatment (curcumin (25 muM) and sorafenib (2 muM)) resulted in a reduction in cell colony formation and significantly decreased the invasion and migration of FTC133 cells compared with that treated with individual drugs.	Curcumin	20-28	latexin	Homo sapiens	33-36
26299635-5	2016	The curcumin was found to dose-dependently inhibit the apoptosis of FTC133 cells possibly via PI3K/Akt and ERK pathways.	Curcumin	4-12	AKT serine/threonine kinase 1	Homo sapiens	99-102
27556215-6	2016	Curcumin treatment at concentrations between 1 and 20 muM reduced the production of iROS in H2O2-exposed TM cells in a dose-dependent manner.	Curcumin	0-8	latexin	Homo sapiens	54-57
27556215-7	2016	Further studies demonstrated that curcumin treatment (20 muM) significantly inhibited proinflammatory factors, including IL-6, ELAM-1, IL-1alpha, and IL-8, whereas it decreased activities of senescence marker SA-beta-gal, and lowered levels of carbonylated proteins and apoptotic cell numbers.	Curcumin	34-42	latexin	Homo sapiens	57-60
27556215-7	2016	Further studies demonstrated that curcumin treatment (20 muM) significantly inhibited proinflammatory factors, including IL-6, ELAM-1, IL-1alpha, and IL-8, whereas it decreased activities of senescence marker SA-beta-gal, and lowered levels of carbonylated proteins and apoptotic cell numbers.	Curcumin	34-42	interleukin 6	Homo sapiens	121-125
27556215-7	2016	Further studies demonstrated that curcumin treatment (20 muM) significantly inhibited proinflammatory factors, including IL-6, ELAM-1, IL-1alpha, and IL-8, whereas it decreased activities of senescence marker SA-beta-gal, and lowered levels of carbonylated proteins and apoptotic cell numbers.	Curcumin	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
26299635-5	2016	The curcumin was found to dose-dependently inhibit the apoptosis of FTC133 cells possibly via PI3K/Akt and ERK pathways.	Curcumin	4-12	mitogen-activated protein kinase 1	Homo sapiens	107-110
26299635-0	2016	Combinatorial anticancer effects of curcumin and sorafenib towards thyroid cancer cells via PI3K/Akt and ERK pathways.	Curcumin	36-44	mitogen-activated protein kinase 1	Homo sapiens	105-108
26134921-7	2016	The results of PCR and Western blotting showed that curcumin increased the FasL mRNA level; inhibited Bcl-2, NF-kappaB, and ERK expression; and activated P38 MAPK, JNK, and caspase-3.	Curcumin	52-60	BCL2 apoptosis regulator	Homo sapiens	102-107
26134921-7	2016	The results of PCR and Western blotting showed that curcumin increased the FasL mRNA level; inhibited Bcl-2, NF-kappaB, and ERK expression; and activated P38 MAPK, JNK, and caspase-3.	Curcumin	52-60	mitogen-activated protein kinase 1	Homo sapiens	124-127
26134921-7	2016	The results of PCR and Western blotting showed that curcumin increased the FasL mRNA level; inhibited Bcl-2, NF-kappaB, and ERK expression; and activated P38 MAPK, JNK, and caspase-3.	Curcumin	52-60	mitogen-activated protein kinase 8	Homo sapiens	164-167
26134921-7	2016	The results of PCR and Western blotting showed that curcumin increased the FasL mRNA level; inhibited Bcl-2, NF-kappaB, and ERK expression; and activated P38 MAPK, JNK, and caspase-3.	Curcumin	52-60	caspase 3	Homo sapiens	173-182
26134921-9	2016	DISCUSSION AND CONCLUSION: This study demonstrates that curcumin not only induces SHI-1 cell apoptosis, possibly via both intrinsic and extrinsic pathways triggered by JNK, P38 MAPK and ERK signaling, but also partially suppresses SHI-1 cell invasion, likely by reducing the levels of transcription and secretion of MMP-2 and MMP-9.	Curcumin	56-64	mitogen-activated protein kinase 8	Homo sapiens	168-171
26134921-9	2016	DISCUSSION AND CONCLUSION: This study demonstrates that curcumin not only induces SHI-1 cell apoptosis, possibly via both intrinsic and extrinsic pathways triggered by JNK, P38 MAPK and ERK signaling, but also partially suppresses SHI-1 cell invasion, likely by reducing the levels of transcription and secretion of MMP-2 and MMP-9.	Curcumin	56-64	mitogen-activated protein kinase 1	Homo sapiens	186-189
27407064-4	2016	Here, we used a sensitive fluorescence-based Abeta digestion assay to screen 25 curcumin analogs for their ability to upregulate NEP activity.	Curcumin	80-88	histocompatibility 2, class II antigen A, beta 1	Mus musculus	45-50
27405665-3	2016	We first demonstrated that curcumin, like docetaxel (DTX), can selectively target CD11b(+)Ly6G(+)Ly6C(low) granulocytic (G)-MDSCs, sparing CD11b(+)Ly6G(-)Ly6C(high) M-MDSCs, with reduced tumor burden in 4T1-Neu tumor-bearing mice.	Curcumin	27-35	integrin alpha M	Mus musculus	82-87
27405665-3	2016	We first demonstrated that curcumin, like docetaxel (DTX), can selectively target CD11b(+)Ly6G(+)Ly6C(low) granulocytic (G)-MDSCs, sparing CD11b(+)Ly6G(-)Ly6C(high) M-MDSCs, with reduced tumor burden in 4T1-Neu tumor-bearing mice.	Curcumin	27-35	integrin alpha M	Mus musculus	139-144
27113027-0	2016	Interference with Akt signaling pathway contributes curcumin-induced adipocyte insulin resistance.	Curcumin	52-60	thymoma viral proto-oncogene 1	Mus musculus	18-21
27405665-4	2016	Curcumin treatment polarized surviving M-MDSCs toward CCR7(+) Dectin-1(-)M1 cells, accompanied by IFN-gamma production and cytolytic function in T cells.	Curcumin	0-8	C-C motif chemokine receptor 7	Homo sapiens	54-58
27405665-4	2016	Curcumin treatment polarized surviving M-MDSCs toward CCR7(+) Dectin-1(-)M1 cells, accompanied by IFN-gamma production and cytolytic function in T cells.	Curcumin	0-8	interferon gamma	Homo sapiens	98-107
27381056-0	2016	Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1beta via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	64-72
27381056-0	2016	Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1beta via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling.	Curcumin	0-8	NLR family pyrin domain containing 1	Homo sapiens	100-105
27381056-0	2016	Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1beta via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	128-133
27381056-3	2016	The present study showed that repeated intraperitoneal injection of curcumin ameliorated SNI-induced mechanical and cold allodynia in a dose-dependent manner and inhibited the elevation of spinal mature IL-1beta protein levels.	Curcumin	68-76	interleukin 1 beta	Homo sapiens	203-211
27381056-4	2016	Additionally, repeated curcumin treatment significantly inhibited the aggregation of the NALP1 inflammasome and the activation of the JAK2-STAT3 cascade in spinal astrocytes.	Curcumin	23-31	NLR family pyrin domain containing 1	Homo sapiens	89-94
27381056-4	2016	Additionally, repeated curcumin treatment significantly inhibited the aggregation of the NALP1 inflammasome and the activation of the JAK2-STAT3 cascade in spinal astrocytes.	Curcumin	23-31	signal transducer and activator of transcription 3	Homo sapiens	139-144
27381056-6	2016	Our results suggest that curcumin attenuated neuropathic pain and down-regulated the production of spinal mature IL-1beta by inhibiting the aggregation of NALP1 inflammasome and the activation of the JAK2-STAT3 cascade in astrocytes.	Curcumin	25-33	interleukin 1 beta	Homo sapiens	113-121
27381056-6	2016	Our results suggest that curcumin attenuated neuropathic pain and down-regulated the production of spinal mature IL-1beta by inhibiting the aggregation of NALP1 inflammasome and the activation of the JAK2-STAT3 cascade in astrocytes.	Curcumin	25-33	NLR family pyrin domain containing 1	Homo sapiens	155-160
27381056-6	2016	Our results suggest that curcumin attenuated neuropathic pain and down-regulated the production of spinal mature IL-1beta by inhibiting the aggregation of NALP1 inflammasome and the activation of the JAK2-STAT3 cascade in astrocytes.	Curcumin	25-33	signal transducer and activator of transcription 3	Homo sapiens	205-210
27113027-3	2016	Here we experimentally demonstrate that curcumin inhibited the ubiquitin-proteasome system (UPS) function, activated autophagy, and reduced protein levels of protein kinase B (Akt) in a dose- and time-dependent manner in 3T3-L1 adipocytes, accompanied with attenuation of insulin-stimulated Akt phosphorylation, plasma membrane translocation of glucose transporter type 4 (GLUT4), and glucose uptake.	Curcumin	40-48	thymoma viral proto-oncogene 1	Mus musculus	176-179
27113027-3	2016	Here we experimentally demonstrate that curcumin inhibited the ubiquitin-proteasome system (UPS) function, activated autophagy, and reduced protein levels of protein kinase B (Akt) in a dose- and time-dependent manner in 3T3-L1 adipocytes, accompanied with attenuation of insulin-stimulated Akt phosphorylation, plasma membrane translocation of glucose transporter type 4 (GLUT4), and glucose uptake.	Curcumin	40-48	thymoma viral proto-oncogene 1	Mus musculus	291-294
27113027-3	2016	Here we experimentally demonstrate that curcumin inhibited the ubiquitin-proteasome system (UPS) function, activated autophagy, and reduced protein levels of protein kinase B (Akt) in a dose- and time-dependent manner in 3T3-L1 adipocytes, accompanied with attenuation of insulin-stimulated Akt phosphorylation, plasma membrane translocation of glucose transporter type 4 (GLUT4), and glucose uptake.	Curcumin	40-48	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	345-371
27113027-3	2016	Here we experimentally demonstrate that curcumin inhibited the ubiquitin-proteasome system (UPS) function, activated autophagy, and reduced protein levels of protein kinase B (Akt) in a dose- and time-dependent manner in 3T3-L1 adipocytes, accompanied with attenuation of insulin-stimulated Akt phosphorylation, plasma membrane translocation of glucose transporter type 4 (GLUT4), and glucose uptake.	Curcumin	40-48	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	373-378
27113027-4	2016	These in vitro inhibitory effects of curcumin on Akt protein expression and insulin action were reversed by pharmacological and genetic inhibition of autophagy but not by inhibition of the UPS and caspases.	Curcumin	37-45	thymoma viral proto-oncogene 1	Mus musculus	49-52
27113027-5	2016	In addition, Akt reduction in adipose tissues of mice treated with curcumin could be recovered by administration of autophagy inhibitor bafilomycin A1 (BFA).	Curcumin	67-75	thymoma viral proto-oncogene 1	Mus musculus	13-16
27175795-0	2016	External Zn(2+) binding to cysteine-substituted cystic fibrosis transmembrane conductance regulator constructs regulates channel gating and curcumin potentiation.	Curcumin	140-148	CF transmembrane conductance regulator	Homo sapiens	48-99
27261574-0	2016	Curcumin and Ellagic acid synergistically induce ROS generation, DNA damage, p53 accumulation and apoptosis in HeLa cervical carcinoma cells.	Curcumin	0-8	tumor protein p53	Homo sapiens	77-80
27261574-5	2016	Besides this, Curcumin and Ellagic acid also restore p53, induce ROS formation and DNA damage.	Curcumin	14-22	tumor protein p53	Homo sapiens	53-56
27278959-9	2016	Furthermore, curcumin increased the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), but AMPK inhibitor BML-275 significantly abolished the curcumin downregulation of HK, PFK2, and glut4.	Curcumin	167-175	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	116-120
27208432-0	2016	PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia.	Curcumin	85-93	AKT serine/threonine kinase 1	Homo sapiens	5-8
27208432-3	2016	We hypothesized that curcumin supplementation could reduce the inflammatory responses of activated microglial cells modulating PI3K/Akt pathway.	Curcumin	21-29	AKT serine/threonine kinase 1	Homo sapiens	132-135
27208432-8	2016	Curcumin significantly attenuated, in a dose-dependent manner, LPS-induced release of NO and pro-inflammatory cytokines, as well as iNOS expression.	Curcumin	0-8	nitric oxide synthase 2	Homo sapiens	132-136
27208432-9	2016	Interestingly, curcumin was able to reduce, again in a dose-dependent manner, PI3K/Akt phosphorylation as well as NF-kappaB activation in LPS-activated microglial cells.	Curcumin	15-23	AKT serine/threonine kinase 1	Homo sapiens	83-86
27208432-10	2016	Overall these results suggest that curcumin plays an important role in the attenuation of LPS-induced inflammatory responses in microglial cells and that the mechanisms involve down-regulation of the PI3K/Akt signalling.	Curcumin	35-43	AKT serine/threonine kinase 1	Homo sapiens	205-208
27278959-0	2016	Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate-activated protein kinase.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	93-141
27278959-9	2016	Furthermore, curcumin increased the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), but AMPK inhibitor BML-275 significantly abolished the curcumin downregulation of HK, PFK2, and glut4.	Curcumin	13-21	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	55-103
27278959-9	2016	Furthermore, curcumin increased the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), but AMPK inhibitor BML-275 significantly abolished the curcumin downregulation of HK, PFK2, and glut4.	Curcumin	13-21	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	105-109
27278959-11	2016	These results collectively indicated that curcumin inhibited glycolysis in an AMPK activation-dependent manner in HSCs.	Curcumin	42-50	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	78-82
26912222-8	2016	Curcumin inhibited TGFbeta1- and thrombin-induced CCN2 synthesis.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	19-27
26912222-13	2016	Moreover, curcumin dose dependently decreased thrombin-induced activated TGFbeta1 levels.	Curcumin	10-18	coagulation factor II, thrombin	Homo sapiens	46-54
26912222-8	2016	Curcumin inhibited TGFbeta1- and thrombin-induced CCN2 synthesis.	Curcumin	0-8	coagulation factor II, thrombin	Homo sapiens	33-41
26912222-13	2016	Moreover, curcumin dose dependently decreased thrombin-induced activated TGFbeta1 levels.	Curcumin	10-18	transforming growth factor beta 1	Homo sapiens	73-81
26912222-14	2016	Curcumin-inhibited thrombin-induced CCN2 synthesis in human gingival fibroblasts is caused by the suppression of latent TGFbeta1 activation.	Curcumin	0-8	coagulation factor II, thrombin	Homo sapiens	19-27
27482284-7	2016	All of the studies indicated that curcumin decreased glioblastoma cell viability through various pathways (i.e. decrease in prosurvival proteins such as nuclear factor kappaB, activator protein 1, and phosphoinositide 3 kinase, and upregulation of apoptotic pathways like p21, p53, and executor caspase 3).	Curcumin	34-42	tumor protein p53	Homo sapiens	277-280
26912222-14	2016	Curcumin-inhibited thrombin-induced CCN2 synthesis in human gingival fibroblasts is caused by the suppression of latent TGFbeta1 activation.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	120-128
27220352-7	2016	Curcumin reduced FFA influx into the liver by blocking FFA trafficking, and then prevented diacylglycerol deposits and PKCepsilon translocation in the liver, resultantly improving insulin action in the suppression of hepatic gluconeogenesis.	Curcumin	0-8	insulin	Homo sapiens	180-187
27220352-8	2016	Curcumin decreased adipose lipolysis by attenuating ER stress through the cAMP/PKA pathway, reduced FFA influx into the liver by blocking FFA trafficking, and thereby improved insulin sensitivity to inhibit hepatic glucose production.	Curcumin	0-8	insulin	Homo sapiens	176-183
27220352-9	2016	These findings suggested a novel pathway of curcumin to prevent lipid deposits and insulin resistance in liver by beneficial regulation of adipose function.	Curcumin	44-52	insulin	Homo sapiens	83-90
26915483-0	2016	The Effect of Dietary Supplementation With Curcumin on Redox Status and Nrf2 Activation in Patients With Nondiabetic or Diabetic Proteinuric Chronic Kidney Disease: A Pilot Study.	Curcumin	43-51	NFE2 like bZIP transcription factor 2	Homo sapiens	72-76
26915483-2	2016	This study was designed to evaluate the effect of the dietary supplementation with curcumin (CUR) on the redox status and the nuclear factor erythroid 2-related factor 2 (Nrf2) activation in patients with nondiabetic or diabetic proteinuric CKD.	Curcumin	83-91	NFE2 like bZIP transcription factor 2	Homo sapiens	126-169
27482284-7	2016	All of the studies indicated that curcumin decreased glioblastoma cell viability through various pathways (i.e. decrease in prosurvival proteins such as nuclear factor kappaB, activator protein 1, and phosphoinositide 3 kinase, and upregulation of apoptotic pathways like p21, p53, and executor caspase 3).	Curcumin	34-42	caspase 3	Homo sapiens	295-304
26815506-0	2016	Curcumin analogue, A13, exhibits anti-leukemia effect via inhibiting STAT3.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	69-74
27390600-9	2016	Curcumin treated cells showed 3-fold more caspase3/7 activity whereas combination treated cells showed 5-fold more activity compared to control and silymarin treated cells.	Curcumin	0-8	caspase 3	Homo sapiens	42-50
27060762-7	2016	The significant cytotoxicity and tubulin polymerization inhibition by A-2 was further rationalized by docking studies where it was docked at the curcumin binding site of tubulin.	Curcumin	145-153	ATPase H+ transporting V0 subunit a2	Homo sapiens	70-73
27302110-13	2016	The results showed that curcumin treatment led to less macrophage infiltration and less local inflammatory responses as demonstrated by decreasing TNF-alpha, IL-1, and IL-6 levels.	Curcumin	24-32	tumor necrosis factor	Mus musculus	147-156
27514545-0	2016	[Protective effect of Nrf2 activation by curcumin against lead-induced toxicity and apoptosis in SH-SY5Y cells].	Curcumin	41-49	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
27514545-1	2016	OBJECTIVE: To study the protective effect of nuclear factor erythroid 2-related factor 2 (Nrf2) activation by curcumin against lead-induced toxicity and apoptosis in SH-SY5Y human neuroblastoma cells and its impact on expression of apoptosis-related proteins.	Curcumin	110-118	NFE2 like bZIP transcription factor 2	Homo sapiens	45-88
27514545-1	2016	OBJECTIVE: To study the protective effect of nuclear factor erythroid 2-related factor 2 (Nrf2) activation by curcumin against lead-induced toxicity and apoptosis in SH-SY5Y human neuroblastoma cells and its impact on expression of apoptosis-related proteins.	Curcumin	110-118	NFE2 like bZIP transcription factor 2	Homo sapiens	90-94
27514545-11	2016	Curcumin of 5.0 mumol/L significantly reduced the expression of Bax, cytochrome C, and caspase-3 in the high-dose group (P&lt;0.05).	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	64-67
27514545-11	2016	Curcumin of 5.0 mumol/L significantly reduced the expression of Bax, cytochrome C, and caspase-3 in the high-dose group (P&lt;0.05).	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	69-81
27514545-11	2016	Curcumin of 5.0 mumol/L significantly reduced the expression of Bax, cytochrome C, and caspase-3 in the high-dose group (P&lt;0.05).	Curcumin	0-8	caspase 3	Homo sapiens	87-96
27514545-12	2016	CONCLUSION: Nrf2 activation by curcumin has a protective effect against lead-induced toxicity and apoptosis in SH-SY5Y cells.	Curcumin	31-39	NFE2 like bZIP transcription factor 2	Homo sapiens	12-16
27243766-1	2016	Using soy protein isolate (SPI) and soy-soluble polysaccharides (SSPS) as polymer matrixes, this study reported a novel process to fabricate unique core-shell complex (nano)particles to perform as carriers for curcumin (a typical poorly soluble bioactive).	Curcumin	210-218	chromogranin A	Homo sapiens	27-30
27243766-6	2016	The bioaccessibility of curcumin in the SPI-curcumin complexes was unaffected by the SSPS coating.	Curcumin	24-32	chromogranin A	Homo sapiens	40-43
27243766-6	2016	The bioaccessibility of curcumin in the SPI-curcumin complexes was unaffected by the SSPS coating.	Curcumin	44-52	chromogranin A	Homo sapiens	40-43
27302110-13	2016	The results showed that curcumin treatment led to less macrophage infiltration and less local inflammatory responses as demonstrated by decreasing TNF-alpha, IL-1, and IL-6 levels.	Curcumin	24-32	interleukin 6	Mus musculus	168-172
27228201-9	2016	Finally, we have shown that the inclusion complex of alpha-CD and curcumin (CCC) preferentially enters into the human lung cancer cell (A549) as compared to the normal lung fibroblast cell (WI38), causes apoptotic death, activates tumor suppressor protein (p53) and cyclin-dependent kinase inhibitor 1 (p21), and inhibits 3D spheroid growth of cancer cell.	Curcumin	66-74	tumor protein p53	Homo sapiens	257-260
27283735-3	2016	Curcumin is known to activate 20S proteasome and promotes the degradation of intrinsically unfolded p53 tumor suppressor protein.	Curcumin	0-8	tumor protein p53	Homo sapiens	100-103
27228201-9	2016	Finally, we have shown that the inclusion complex of alpha-CD and curcumin (CCC) preferentially enters into the human lung cancer cell (A549) as compared to the normal lung fibroblast cell (WI38), causes apoptotic death, activates tumor suppressor protein (p53) and cyclin-dependent kinase inhibitor 1 (p21), and inhibits 3D spheroid growth of cancer cell.	Curcumin	66-74	cyclin dependent kinase inhibitor 1A	Homo sapiens	266-301
27228201-9	2016	Finally, we have shown that the inclusion complex of alpha-CD and curcumin (CCC) preferentially enters into the human lung cancer cell (A549) as compared to the normal lung fibroblast cell (WI38), causes apoptotic death, activates tumor suppressor protein (p53) and cyclin-dependent kinase inhibitor 1 (p21), and inhibits 3D spheroid growth of cancer cell.	Curcumin	66-74	cyclin dependent kinase inhibitor 1A	Homo sapiens	303-306
26955781-9	2016	Expression of the activated form of the MAP kinase p38 (p-p38) was significantly decreased in curcumin-treated SCs.	Curcumin	94-102	mitogen-activated protein kinase 14	Homo sapiens	51-54
27258084-8	2016	In the present study, we performed in silico studies to quantitatively scrutinize the molecular interaction of curcumin and its structural analogs with COX-2, COX-1, FXa and integrin alphaIIbbetaIII to investigate their therapeutic potential as a cardiovascular-safe anti-inflammatory medicine (CVSAIM).	Curcumin	111-119	prostaglandin-endoperoxide synthase 2	Homo sapiens	152-157
27260322-9	2016	RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta.	Curcumin	14-22	interleukin 1 beta	Mus musculus	121-129
27260322-9	2016	RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta.	Curcumin	14-22	tumor necrosis factor	Mus musculus	134-162
27260322-9	2016	RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta.	Curcumin	14-22	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	253-259
27260322-9	2016	RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta.	Curcumin	14-22	interleukin 1 beta	Mus musculus	324-332
27260322-9	2016	RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta.	Curcumin	55-63	interleukin 1 beta	Mus musculus	121-129
27260322-9	2016	RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta.	Curcumin	55-63	tumor necrosis factor	Mus musculus	134-162
27260322-9	2016	RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta.	Curcumin	55-63	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Mus musculus	253-259
27260322-9	2016	RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta.	Curcumin	55-63	interleukin 1 beta	Mus musculus	324-332
26955781-9	2016	Expression of the activated form of the MAP kinase p38 (p-p38) was significantly decreased in curcumin-treated SCs.	Curcumin	94-102	mitogen-activated protein kinase 14	Homo sapiens	58-61
26970969-1	2016	The aim of the present study was to investigate the protective effects of curcumin alone and in combination with piperine against lipopolysaccharide (LPS)-induced neurobehavioral and neurochemical deficits in the mice hippocampus.	Curcumin	74-82	toll-like receptor 4	Mus musculus	150-153
27448781-12	2016	Curcumin significantly reduced the expression of TNF-alpha and TGF-beta1, which is in line with the decreased numbers of intrahepatic Gr1hi monocytes.	Curcumin	0-8	tumor necrosis factor	Mus musculus	49-58
26970969-9	2016	Pretreatment with curcumin alleviated LPS-induced neurobehavioral and neurochemical deficits.	Curcumin	18-26	toll-like receptor 4	Mus musculus	38-41
26970969-11	2016	These results demonstrate that piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.	Curcumin	79-87	toll-like receptor 4	Mus musculus	96-99
26845728-12	2016	Curcumin supplementation decreased plasma levels of TC, TAG, VLDL-c, TNF-alpha and increased HDL-c. Administration of curcumin also reduced MDA, TOS in skeletal muscle, hepatic TAG content and liver fat deposition.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	69-78
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	cadherin 1	Homo sapiens	130-140
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	twist family bHLH transcription factor 1	Homo sapiens	160-166
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	signal transducer and activator of transcription 3	Homo sapiens	189-195
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	fibronectin 1	Homo sapiens	197-208
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	tumor protein p53	Homo sapiens	220-223
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	caveolin 1	Homo sapiens	228-238
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	caspase 3	Homo sapiens	267-276
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	nuclear factor kappa B subunit 1	Homo sapiens	322-330
27482338-6	2016	Within the group with same induction, curcumin pre-treatment significantly improved metabolic (total cholesterol, glycaemia, triglycerides, AST, ALT; P&lt;0.05) and oxidative stress parameters (total oxidative status (NOx), Thiol, and malondialdehyde (MDA), P&lt;0.02) compared to untreated groups.	Curcumin	38-46	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	140-143
27482338-7	2016	CONCLUSION: The pre-treatment with curcumin in our experimental models significantly improved metabolic (total cholesterol, triglycerides, AST and ALT) as well as oxidative stress parameters (MDA, NOx, and Thiol) in both fructose diet and in STZ-induced diabetes in rats.	Curcumin	35-43	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	139-142
26845728-12	2016	Curcumin supplementation decreased plasma levels of TC, TAG, VLDL-c, TNF-alpha and increased HDL-c. Administration of curcumin also reduced MDA, TOS in skeletal muscle, hepatic TAG content and liver fat deposition.	Curcumin	118-126	tumor necrosis factor	Rattus norvegicus	69-78
27146402-6	2016	Using luciferase reporters with an entire AT1 or a mutant AT1R in A10 cells, the AT1R promoter activity was inhibited by 10(-6 )M curcumin, and the proximal element (from -61 to +25 bp) of the AT1R promoter was crucial for curcumin-induced AT1R down-regulation.	Curcumin	130-138	angiotensin II receptor, type 1a	Mus musculus	42-45
27026405-10	2016	Furthermore, transfection with constitutive active MKK6 or HA-p38 MAPK vectors rescued the XRCC1 protein level and also the cell survival suppressed by cisplatin and curcumin combination in A549 and H1703 cells.	Curcumin	166-174	mitogen-activated protein kinase kinase 6	Homo sapiens	51-55
27026405-10	2016	Furthermore, transfection with constitutive active MKK6 or HA-p38 MAPK vectors rescued the XRCC1 protein level and also the cell survival suppressed by cisplatin and curcumin combination in A549 and H1703 cells.	Curcumin	166-174	BAG cochaperone 1	Homo sapiens	59-63
27313684-0	2016	MiR-593 mediates curcumin-induced radiosensitization of nasopharyngeal carcinoma cells via MDR1.	Curcumin	17-25	ATP binding cassette subfamily B member 1	Homo sapiens	91-95
26962150-4	2016	Here, we characterize a novel curcumin analog, ASC-JM17, as an activator of central pathways controlling protein folding, degradation and oxidative stress resistance.	Curcumin	30-38	asense	Drosophila melanogaster	47-50
27152196-5	2016	Moreover, curcumin, an intracellularly cleaved product of PCDA, can effectively down regulate the expression of drug efflux transporters such as P-glycoprotein (P-gp) to increase PTX accumulation within target cancer cells, thereby enhancing PTX induced cytotoxicity and therapeutic efficacy against MCF-7/ADR cells.	Curcumin	10-18	ATP binding cassette subfamily B member 1	Homo sapiens	161-165
26872103-0	2016	Curcumin Ameliorates Reserpine-Induced Gastrointestinal Mucosal Lesions Through Inhibiting IkappaB-alpha/NF-kappaB Pathway and Regulating Expression of Vasoactive Intestinal Peptide and Gastrin in Rats.	Curcumin	0-8	vasoactive intestinal peptide	Rattus norvegicus	152-181
26872103-8	2016	Curcumin treatment prevented tissue damage and cell death in the reserpine-treated rats and effectively decreased inflammatory response and balanced the expression of VIP and gastrin in the reserpine-treated rats.	Curcumin	0-8	vasoactive intestinal peptide	Rattus norvegicus	167-170
26872103-10	2016	Curcumin can target the IkappaB-alpha/NF-kappaB pathway to inhibit inflammatory response and regulate the level of VIP and gastrin in reserpine-induced GML rats.	Curcumin	0-8	vasoactive intestinal peptide	Rattus norvegicus	115-118
27026405-0	2016	Curcumin downregulates p38 MAPK-dependent X-ray repair cross-complement group 1 (XRCC1) expression to enhance cisplatin-induced cytotoxicity in human lung cancer cells.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	23-26
27026405-4	2016	In this study, we characterize the role of curcumin in the cytotoxicity, p38 MAPK activation, and XRCC1 expression affected by cisplatin in NSCLC cells.	Curcumin	43-51	mitogen-activated protein kinase 14	Homo sapiens	73-76
27313760-0	2016	Pyridine analogues of curcumin exhibit high activity for inhibiting CWR-22Rv1 human prostate cancer cell growth and androgen receptor activation.	Curcumin	22-30	androgen receptor	Homo sapiens	116-133
27313760-6	2016	Thus, the results of the present study indicate the inhibition of the AR pathways as a potential mechanism for the anticancer effect of curcumin analogues in human prostate cancer cells.	Curcumin	136-144	androgen receptor	Homo sapiens	70-72
27313760-7	2016	Furthermore, curcumin analogues with pyridine as a distal ring and tetrahydrothiopyran-4-one as a linker may be good candidates for the development of novel drugs for the treatment of prostate cancer, by targeting the AR signaling pathway.	Curcumin	13-21	androgen receptor	Homo sapiens	218-220
27274242-9	2016	Along with the maintenance of cellular ROS levels, nanoparticulated curcumin also significantly (P&lt;0.0001) increased cellular antioxidant enzymes, averted excessive mitochondrial destruction, and prevented total liver damage in CCl4-treated rats.	Curcumin	68-76	C-C motif chemokine ligand 4	Rattus norvegicus	231-235
27274242-12	2016	To conclude, curcumin-loaded polymeric nanoparticles are more effective in comparison to liposomal curcumin in preventing CCl4-induced oxidative stress-mediated hepatocellular damage and thereby can be considered as an effective therapeutic strategy.	Curcumin	13-21	C-C motif chemokine ligand 4	Rattus norvegicus	122-126
26945822-8	2016	In conclusion, this curcumin derivative attenuates liver fibrosis likely involving a CB/JNK/NF-kappaB-mediated pathway.	Curcumin	20-28	mitogen-activated protein kinase 8	Homo sapiens	88-91
26945822-8	2016	In conclusion, this curcumin derivative attenuates liver fibrosis likely involving a CB/JNK/NF-kappaB-mediated pathway.	Curcumin	20-28	nuclear factor kappa B subunit 1	Homo sapiens	92-101
27152196-5	2016	Moreover, curcumin, an intracellularly cleaved product of PCDA, can effectively down regulate the expression of drug efflux transporters such as P-glycoprotein (P-gp) to increase PTX accumulation within target cancer cells, thereby enhancing PTX induced cytotoxicity and therapeutic efficacy against MCF-7/ADR cells.	Curcumin	10-18	ATP binding cassette subfamily B member 1	Homo sapiens	145-159
27026486-8	2016	Moreover, Western blot analysis and immunostaining indicated that treatment with curcumin significantly reduced the expression of a vascular cell adhesion molecule-1 (VCAM-1), interferon-gamma (INF-gamma) and interleukin-17 (IL-17) in the mouse brain at 72h post-ICH.	Curcumin	81-89	interferon gamma	Mus musculus	176-192
27026486-8	2016	Moreover, Western blot analysis and immunostaining indicated that treatment with curcumin significantly reduced the expression of a vascular cell adhesion molecule-1 (VCAM-1), interferon-gamma (INF-gamma) and interleukin-17 (IL-17) in the mouse brain at 72h post-ICH.	Curcumin	81-89	interferon gamma	Mus musculus	194-203
26838071-0	2016	Curcumin attenuates high glucose-induced podocyte apoptosis by regulating functional connections between caveolin-1 phosphorylation and ROS.	Curcumin	0-8	caveolin 1	Rattus norvegicus	105-115
26838071-4	2016	In this study we investigated whether regulating the functional connections between cav-1 and ROS in kidneys contributed to the beneficial effects of curcumin in treating diabetic nephropathy in vitro and in vivo.	Curcumin	150-158	caveolin 1	Rattus norvegicus	84-89
26838071-11	2016	In diabetic rats, administration of curcumin (100 or 200 mg/kg body weight per day, ig, for 8 weeks) not only significantly improved the renal function, but also suppressed ROS levels, oxidative stress, apoptosis and cav-1 phosphorylation in the kidneys.	Curcumin	36-44	caveolin 1	Rattus norvegicus	217-222
26838071-12	2016	CONCLUSION: Curcumin attenuates high glucose-induced podocyte apoptosis in vitro and diabetic nephropathy in vivo partly through regulating the functional connections between cav-1 phosphorylation and ROS.	Curcumin	12-20	caveolin 1	Rattus norvegicus	175-180
27046748-0	2016	Ovalbumin-induced allergic inflammation lead to structural alterations in mouse model and protective effects of intranasal curcumin: A comparative study.	Curcumin	123-131	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	0-9
26774374-1	2016	Galactosylated alginate-curcumin conjugate (LANH2-Alg Ald-Cur) is synthesized for targeted delivery of curcumin to hepatocytes exploiting asialoglycoprotein receptor (ASGPR) on hepatocytes.	Curcumin	24-32	asialoglycoprotein receptor 1	Homo sapiens	138-165
27049834-0	2016	Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1.	Curcumin	23-31	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	73-77
27049834-0	2016	Anti-cancer effects of curcumin on lung cancer through the inhibition of EZH2 and NOTCH1.	Curcumin	23-31	notch receptor 1	Homo sapiens	82-88
27049834-4	2016	In the present study, we provided evidences that curcumin suppressed the expression of enhancer of zeste homolog 2 (EZH2) in lung cancer cells both transcriptionally and post-transcriptionally.	Curcumin	49-57	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	87-114
27049834-4	2016	In the present study, we provided evidences that curcumin suppressed the expression of enhancer of zeste homolog 2 (EZH2) in lung cancer cells both transcriptionally and post-transcriptionally.	Curcumin	49-57	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	116-120
27049834-5	2016	Curcumin inhibited the expression of EZH2 through microRNA (miR)-let 7c and miR-101.	Curcumin	0-8	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	37-41
27049834-6	2016	Curcumin decreased the expression of NOTCH1 through the inhibition of EZH2.	Curcumin	0-8	notch receptor 1	Homo sapiens	37-43
27049834-6	2016	Curcumin decreased the expression of NOTCH1 through the inhibition of EZH2.	Curcumin	0-8	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	70-74
27049834-8	2016	These observations suggest that curcumin inhibits lung cancer growth and metastasis at least partly through the inhibition of EZH2 and NOTCH1.	Curcumin	32-40	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	126-130
27049834-8	2016	These observations suggest that curcumin inhibits lung cancer growth and metastasis at least partly through the inhibition of EZH2 and NOTCH1.	Curcumin	32-40	notch receptor 1	Homo sapiens	135-141
26774374-1	2016	Galactosylated alginate-curcumin conjugate (LANH2-Alg Ald-Cur) is synthesized for targeted delivery of curcumin to hepatocytes exploiting asialoglycoprotein receptor (ASGPR) on hepatocytes.	Curcumin	24-32	asialoglycoprotein receptor 1	Homo sapiens	167-172
26774374-1	2016	Galactosylated alginate-curcumin conjugate (LANH2-Alg Ald-Cur) is synthesized for targeted delivery of curcumin to hepatocytes exploiting asialoglycoprotein receptor (ASGPR) on hepatocytes.	Curcumin	103-111	asialoglycoprotein receptor 1	Homo sapiens	138-165
26774374-1	2016	Galactosylated alginate-curcumin conjugate (LANH2-Alg Ald-Cur) is synthesized for targeted delivery of curcumin to hepatocytes exploiting asialoglycoprotein receptor (ASGPR) on hepatocytes.	Curcumin	103-111	asialoglycoprotein receptor 1	Homo sapiens	167-172
26985864-5	2016	Curcumin also regulated B-cell lymphoma 2 (Bcl-2), Bax and p-Akt protein expression in MDA-MB-231 cells.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	24-41
25980682-6	2016	CHOP, a key factor involved in ER stress-mediated apoptosis, was also activated by curcumin.	Curcumin	83-91	DNA damage inducible transcript 3	Homo sapiens	0-4
27035875-0	2016	Curcumin induces G2/M arrest and triggers apoptosis via FoxO1 signaling in U87 human glioma cells.	Curcumin	0-8	forkhead box O1	Homo sapiens	56-61
27035875-5	2016	In addition, increased expression of forkhead box protein O1 (FoxO1) and decreased expression of phosphorylated (p)-FoxO1 were detected in the curcumin-treated U87 cells.	Curcumin	143-151	forkhead box O1	Homo sapiens	37-60
27035875-5	2016	In addition, increased expression of forkhead box protein O1 (FoxO1) and decreased expression of phosphorylated (p)-FoxO1 were detected in the curcumin-treated U87 cells.	Curcumin	143-151	forkhead box O1	Homo sapiens	62-67
27035875-5	2016	In addition, increased expression of forkhead box protein O1 (FoxO1) and decreased expression of phosphorylated (p)-FoxO1 were detected in the curcumin-treated U87 cells.	Curcumin	143-151	forkhead box O1	Homo sapiens	116-121
27035875-6	2016	Curcumin was also able to induce the translocation of FoxO1 from the cytoplasm to the nucleus.	Curcumin	0-8	forkhead box O1	Homo sapiens	54-59
27035875-7	2016	Furthermore, following knockdown of FoxO1 expression in curcumin-treated U87 cells using FoxO1 small interfering RNA, the expression levels of cyclin G2, cleaved caspase-3 and FasL were inhibited; however, the expression levels of CDK1 were not markedly altered.	Curcumin	56-64	forkhead box O1	Homo sapiens	36-41
27035875-7	2016	Furthermore, following knockdown of FoxO1 expression in curcumin-treated U87 cells using FoxO1 small interfering RNA, the expression levels of cyclin G2, cleaved caspase-3 and FasL were inhibited; however, the expression levels of CDK1 were not markedly altered.	Curcumin	56-64	forkhead box O1	Homo sapiens	89-94
27035875-9	2016	Furthermore, curcumin-induced G2/M cell cycle arrest and apoptosis could be attenuated by FoxO1 knockdown.	Curcumin	13-21	forkhead box O1	Homo sapiens	90-95
27035875-10	2016	These results indicated that curcumin may induce G2/M cell cycle arrest and apoptosis in U87 cells by increasing FoxO1 expression.	Curcumin	29-37	forkhead box O1	Homo sapiens	113-118
26985864-5	2016	Curcumin also regulated B-cell lymphoma 2 (Bcl-2), Bax and p-Akt protein expression in MDA-MB-231 cells.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	43-48
26985864-5	2016	Curcumin also regulated B-cell lymphoma 2 (Bcl-2), Bax and p-Akt protein expression in MDA-MB-231 cells.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	51-54
27208407-0	2016	Curcumin improves LPS-induced preeclampsia-like phenotype in rat by inhibiting the TLR4 signaling pathway.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	83-87
27025786-0	2016	Curcumin downregulates human tumor necrosis factor-alpha levels: A systematic review and meta-analysis ofrandomized controlled trials.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	29-56
27025786-2	2016	Curcumin, a bioactive polyphenol from turmeric, has been shown in several preclinical studies to block TNF-alpha effectively.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	103-112
27208407-2	2016	Because curcumin can inhibit TLR4 signaling pathway, we investigated its effects on a PE rat model.	Curcumin	8-16	toll-like receptor 4	Rattus norvegicus	29-33
27025786-4	2016	OBJECTIVE: The aim of the present meta-analysis was to evaluate the efficacy of curcumin supplementation on circulating levels of TNF-alpha in randomized controlled trials (RCTs).	Curcumin	80-88	tumor necrosis factor	Homo sapiens	130-139
27025786-5	2016	METHODS: The search included PubMed-Medline, Scopus, Web of Science and Google Scholar databases by up to September 21, 2015, to identify RCTs investigating the impact of curcumin on circulating TNF-alpha concentration.	Curcumin	171-179	tumor necrosis factor	Homo sapiens	195-204
27208407-10	2016	Increased TLR4, NF-kappaB and IL-6, MCP-1 protein expressions in LPS-treated group were significantly decreased after curcumin administration.	Curcumin	118-126	toll-like receptor 4	Rattus norvegicus	10-14
27025786-9	2016	There was a significant reduction of circulating TNF-alpha concentrations following curcumin supplementation (WMD: -4.69pg/mL, 95% CI: -7.10, -2.28, p&lt;0.001).	Curcumin	84-92	tumor necrosis factor	Homo sapiens	49-58
27025786-12	2016	CONCLUSION: This meta-analysis of RCTs suggested a significant effect of curcumin in lowering circulating TNF-alpha concentration.	Curcumin	73-81	tumor necrosis factor	Homo sapiens	106-115
27208407-10	2016	Increased TLR4, NF-kappaB and IL-6, MCP-1 protein expressions in LPS-treated group were significantly decreased after curcumin administration.	Curcumin	118-126	interleukin 6	Rattus norvegicus	30-34
27208407-10	2016	Increased TLR4, NF-kappaB and IL-6, MCP-1 protein expressions in LPS-treated group were significantly decreased after curcumin administration.	Curcumin	118-126	mast cell protease 1-like 1	Rattus norvegicus	36-41
27208407-11	2016	DISCUSSION: Curcumin improves the PE-like phenotype in rat model by reducing abnormal inflammation related to TLR4 signaling pathway.	Curcumin	12-20	toll-like receptor 4	Rattus norvegicus	110-114
27091625-0	2016	Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-kappaB signalling pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	128-137
27043868-5	2016	The objective of this study is to examine whether silymarin alone or in combination with vitamin E and/or curcumin plays a modulatory role against MAPK, STAT3, AKT, Smad-2 and TGF-beta protein expressions that produced apoptotic damage in rat"s liver by the administration of carbon tetrachloride (CCl4).	Curcumin	106-114	AKT serine/threonine kinase 1	Rattus norvegicus	160-163
27043868-5	2016	The objective of this study is to examine whether silymarin alone or in combination with vitamin E and/or curcumin plays a modulatory role against MAPK, STAT3, AKT, Smad-2 and TGF-beta protein expressions that produced apoptotic damage in rat"s liver by the administration of carbon tetrachloride (CCl4).	Curcumin	106-114	transforming growth factor, beta 1	Rattus norvegicus	176-184
27043868-5	2016	The objective of this study is to examine whether silymarin alone or in combination with vitamin E and/or curcumin plays a modulatory role against MAPK, STAT3, AKT, Smad-2 and TGF-beta protein expressions that produced apoptotic damage in rat"s liver by the administration of carbon tetrachloride (CCl4).	Curcumin	106-114	C-C motif chemokine ligand 4	Rattus norvegicus	298-302
26996567-8	2016	RESULTS: Curcumin ameliorated albuminuria, pathophysiologic changes on the glomerulus, urinary MDA, and urinary SOD related with elevated Nrf2 signaling, as well as serum lipid-related index and ectopic lipid accumulation through activation of AMPK signaling.	Curcumin	9-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	138-142
26996567-8	2016	RESULTS: Curcumin ameliorated albuminuria, pathophysiologic changes on the glomerulus, urinary MDA, and urinary SOD related with elevated Nrf2 signaling, as well as serum lipid-related index and ectopic lipid accumulation through activation of AMPK signaling.	Curcumin	9-17	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	244-248
26996567-9	2016	CONCLUSION: Collectively, these findings indicate that curcumin exerts renoprotective effects by inhibiting renal lipid accumulation and oxidative stress through AMPK and Nrf2 signaling pathway.	Curcumin	55-63	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	162-166
26996567-9	2016	CONCLUSION: Collectively, these findings indicate that curcumin exerts renoprotective effects by inhibiting renal lipid accumulation and oxidative stress through AMPK and Nrf2 signaling pathway.	Curcumin	55-63	NFE2 like bZIP transcription factor 2	Rattus norvegicus	171-175
26947919-4	2016	Complex , possessing an appended ferrocenyl (Fc) and the curcumin moiety, is remarkably photocytotoxic to HeLa and MCF-7 cancer cells in visible light giving respective IC50 values of 0.7 muM and 2.1 muM while being significantly less toxic to MCF-10A normal cells (IC50 = 34 muM) and in the dark (IC50 &gt; 50 muM).	Curcumin	57-65	latexin	Homo sapiens	188-191
26947919-4	2016	Complex , possessing an appended ferrocenyl (Fc) and the curcumin moiety, is remarkably photocytotoxic to HeLa and MCF-7 cancer cells in visible light giving respective IC50 values of 0.7 muM and 2.1 muM while being significantly less toxic to MCF-10A normal cells (IC50 = 34 muM) and in the dark (IC50 &gt; 50 muM).	Curcumin	57-65	latexin	Homo sapiens	200-203
26947919-4	2016	Complex , possessing an appended ferrocenyl (Fc) and the curcumin moiety, is remarkably photocytotoxic to HeLa and MCF-7 cancer cells in visible light giving respective IC50 values of 0.7 muM and 2.1 muM while being significantly less toxic to MCF-10A normal cells (IC50 = 34 muM) and in the dark (IC50 &gt; 50 muM).	Curcumin	57-65	latexin	Homo sapiens	200-203
26947919-4	2016	Complex , possessing an appended ferrocenyl (Fc) and the curcumin moiety, is remarkably photocytotoxic to HeLa and MCF-7 cancer cells in visible light giving respective IC50 values of 0.7 muM and 2.1 muM while being significantly less toxic to MCF-10A normal cells (IC50 = 34 muM) and in the dark (IC50 &gt; 50 muM).	Curcumin	57-65	latexin	Homo sapiens	200-203
26991801-0	2016	Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1.	Curcumin	63-71	nuclear factor, erythroid derived 2, like 2	Mus musculus	28-32
26991801-1	2016	It has previously been shown that curcumin can effectively inhibit prostate cancer proliferation and progression in TRAMP mice, potentially acting through the hypomethylation of the Nrf2 gene promoter and hence activation of the Nrf2 pathway to enhance cell antioxidative defense.	Curcumin	34-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	182-186
26991801-1	2016	It has previously been shown that curcumin can effectively inhibit prostate cancer proliferation and progression in TRAMP mice, potentially acting through the hypomethylation of the Nrf2 gene promoter and hence activation of the Nrf2 pathway to enhance cell antioxidative defense.	Curcumin	34-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	229-233
26991801-9	2016	The luciferase reporter assay indicated that FN1 was more potent than curcumin in activating the Nrf2-ARE pathway.	Curcumin	70-78	nuclear factor, erythroid derived 2, like 2	Mus musculus	97-101
27091625-5	2016	Transcriptomic profiling revealed the up-regulation of three NF-kappaB-regulated CXC-chemokines, CXCL8, CXCL1 and CXCL2, in the resistant cells that were more efficiently down-regulated after OXA + Curcumin treatment as compared to the sensitive cells.	Curcumin	198-206	nuclear factor kappa B subunit 1	Homo sapiens	61-70
27091625-5	2016	Transcriptomic profiling revealed the up-regulation of three NF-kappaB-regulated CXC-chemokines, CXCL8, CXCL1 and CXCL2, in the resistant cells that were more efficiently down-regulated after OXA + Curcumin treatment as compared to the sensitive cells.	Curcumin	198-206	C-X-C motif chemokine ligand 8	Homo sapiens	97-102
29235333-9	2016	Curcumin negated the activating effect of Abeta42 on pro-inflammatory cytokines, starting immediately for IL-1beta and on 3-6 hours for TNFalpha, which resulted in decreased extracellular concentrations of these cytokines.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	106-114
29235333-9	2016	Curcumin negated the activating effect of Abeta42 on pro-inflammatory cytokines, starting immediately for IL-1beta and on 3-6 hours for TNFalpha, which resulted in decreased extracellular concentrations of these cytokines.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	136-144
27091625-3	2016	Here, we show that NF-kappaB was hyperactivated in in vitro models of OXA-acquired resistance but was attenuated by the addition of Curcumin, a non-toxic NF-kappaB inhibitor.	Curcumin	132-140	nuclear factor kappa B subunit 1	Homo sapiens	19-28
27091625-3	2016	Here, we show that NF-kappaB was hyperactivated in in vitro models of OXA-acquired resistance but was attenuated by the addition of Curcumin, a non-toxic NF-kappaB inhibitor.	Curcumin	132-140	nuclear factor kappa B subunit 1	Homo sapiens	154-163
27091625-4	2016	The concomitant combination of Curcumin + OXA was more effective and synergistic in cell lines with acquired resistance to OXA, leading to the reversion of their resistant phenotype, through the inhibition of the NF-kappaB signalling cascade.	Curcumin	31-39	nuclear factor kappa B subunit 1	Homo sapiens	213-222
26983836-0	2016	Selective Modulation of Protein Kinase C alpha over Protein Kinase C epsilon by Curcumin and Its Derivatives in CHO-K1 Cells.	Curcumin	80-88	protein kinase C epsilon type	Cricetulus griseus	52-76
27110686-0	2016	Proteasome inhibitors, including curcumin, improve pancreatic beta-cell function and insulin sensitivity in diabetic mice.	Curcumin	33-41	insulin	Homo sapiens	85-92
27110686-2	2016	Recent work by our group and others has shown that the natural polyphenol curcumin attenuates the development of insulin resistance and hyperglycemia in mouse models of hyperinsulinemic or compensated type 2 diabetes.	Curcumin	74-82	insulin	Homo sapiens	113-120
27110686-4	2016	We now show that curcumin also prevents beta-cell failure in a mouse model of uncompensated obesity-related insulin resistance (Lepr(db/db) on the Kaliss background).	Curcumin	17-25	insulin	Homo sapiens	108-115
27110686-5	2016	RESULTS: In this instance, dietary supplementation with curcumin prevented hyperglycemia, increased insulin production and lean body mass, and prolonged lifespan.	Curcumin	56-64	insulin	Homo sapiens	100-107
27010501-0	2016	Evaluation of the anti-inflammatory action of curcumin analog (DM1): Effect on iNOS and COX-2 gene expression and autophagy pathways.	Curcumin	46-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
27010501-1	2016	This work describes the anti-inflammatory effect of the curcumin-analog compound, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate (DM1), and shows that DM1 modulates iNOS and COX-2 gene expression in cultured RAW 264.7 cells and induces autophagy on human melanoma cell line A375.	Curcumin	56-64	nitric oxide synthase 2, inducible	Mus musculus	202-206
27513263-8	2016	Superoxide, catalase, GSH-Px, conjugate dienes, and AOPP were lower in the curcumin groups than they were in the controls.	Curcumin	75-83	catalase	Rattus norvegicus	12-20
26850372-0	2016	Inhibition of NF-kappaB translocation by curcumin analogs induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer.	Curcumin	41-49	nuclear factor kappa B subunit 1	Homo sapiens	14-23
26850372-3	2016	Curcumin is a potent inhibitor of NF-kappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	34-43
26850372-5	2016	We tested the hypothesis that inhibition of NF-kappaB translocation by curcumin and its analogs EF31 and UBS109 can inhibit cell cycle progression and downregulate TS levels in colorectal cancer (CRC) cell lines.	Curcumin	71-79	nuclear factor kappa B subunit 1	Homo sapiens	44-53
26908114-11	2016	Release studies show that curcumin is released over 19 days from the polymer and maintains a concentration of 0.23 +- 0.12 muM curcumin/mg polymer/mL solution based on 1% curcumin loading on the polymer.	Curcumin	26-34	latexin	Homo sapiens	123-126
26908114-11	2016	Release studies show that curcumin is released over 19 days from the polymer and maintains a concentration of 0.23 +- 0.12 muM curcumin/mg polymer/mL solution based on 1% curcumin loading on the polymer.	Curcumin	127-135	latexin	Homo sapiens	123-126
26850372-7	2016	Treatment with curcumin, EF31 or UBS109 inhibited NF-kappaB, downregulated survival pathways and inhibited cell cycle progression.	Curcumin	15-23	nuclear factor kappa B subunit 1	Homo sapiens	50-59
26908114-11	2016	Release studies show that curcumin is released over 19 days from the polymer and maintains a concentration of 0.23 +- 0.12 muM curcumin/mg polymer/mL solution based on 1% curcumin loading on the polymer.	Curcumin	127-135	latexin	Homo sapiens	123-126
26803409-0	2016	Photoprotective efficiency of PLGA-curcumin nanoparticles versus curcumin through the involvement of ERK/AKT pathway under ambient UV-R exposure in HaCaT cell line.	Curcumin	35-43	mitogen-activated protein kinase 1	Homo sapiens	101-104
26735343-8	2016	The RT-PCR assessment of caspase-3 expression revealed that there was a significant increase in caspase-3 expression in Hep-2 cell line treated with 5-fluorouracil nanoparticles or curcumin compared to non treated cancer cells.	Curcumin	181-189	caspase 3	Homo sapiens	25-34
26735343-8	2016	The RT-PCR assessment of caspase-3 expression revealed that there was a significant increase in caspase-3 expression in Hep-2 cell line treated with 5-fluorouracil nanoparticles or curcumin compared to non treated cancer cells.	Curcumin	181-189	caspase 3	Homo sapiens	96-105
26826458-4	2016	Results showed that, 10 muM of curcumin significantly inhibited secretion of inflammatory factors including interleukin (IL)-17,IL-22, IFN-gamma, IL-2, IL-8 and TNF-alpha in T cells by 30-60% in vitro.	Curcumin	31-39	interferon gamma	Mus musculus	135-144
26826458-4	2016	Results showed that, 10 muM of curcumin significantly inhibited secretion of inflammatory factors including interleukin (IL)-17,IL-22, IFN-gamma, IL-2, IL-8 and TNF-alpha in T cells by 30-60% in vitro.	Curcumin	31-39	tumor necrosis factor	Mus musculus	161-170
26826458-8	2016	More than 50% level of inflammatory factors including TNF-alpha, IFN-gamma, IL-2, IL-12, IL-22 and IL-23 in mouse serum was decreased by curcumin treatment as well as cyclosporine.	Curcumin	137-145	tumor necrosis factor	Mus musculus	54-63
26826458-8	2016	More than 50% level of inflammatory factors including TNF-alpha, IFN-gamma, IL-2, IL-12, IL-22 and IL-23 in mouse serum was decreased by curcumin treatment as well as cyclosporine.	Curcumin	137-145	interferon gamma	Mus musculus	65-74
26978516-4	2016	The results showed that curcumin induced liver injury through the generation of the overexpression of reactive oxygen species (ROS) and pro-inflammatory cytokines IL-6 and the decreases of the levels of antioxidant enzyme SOD and detoxified enzyme GST.	Curcumin	24-32	interleukin 6	Rattus norvegicus	163-167
26978516-5	2016	Meanwhile, for the self-protection of rats, curcumin treatment activated the transcription of Nrf-2 and elevated the expression of HO-1 to reduce tissue damage.	Curcumin	44-52	NFE2 like bZIP transcription factor 2	Rattus norvegicus	94-99
26803409-0	2016	Photoprotective efficiency of PLGA-curcumin nanoparticles versus curcumin through the involvement of ERK/AKT pathway under ambient UV-R exposure in HaCaT cell line.	Curcumin	35-43	AKT serine/threonine kinase 1	Homo sapiens	105-108
26803409-5	2016	Molecular docking studies suggested that intact curcumin from nanoparticles, bind with BAX in BIM SAHB site and attenuate it to undergo apoptosis while upregulating anti-apoptotic genes like BCL2.	Curcumin	48-56	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90
26803409-5	2016	Molecular docking studies suggested that intact curcumin from nanoparticles, bind with BAX in BIM SAHB site and attenuate it to undergo apoptosis while upregulating anti-apoptotic genes like BCL2.	Curcumin	48-56	BCL2 apoptosis regulator	Homo sapiens	191-195
27190933-11	2016	Subtoxic concentrations of the curcumin-TRAIL combination induced strong apoptotic response in KCL-22 cells as demonstrated by the binding of Annexin V-FITC.	Curcumin	31-39	TNF superfamily member 10	Homo sapiens	40-45
27106025-0	2016	c-Jun N-terminal kinase-dependent apoptotic photocytotoxicity of solvent exchange-prepared curcumin nanoparticles.	Curcumin	91-99	mitogen-activated protein kinase 8	Homo sapiens	0-23
26776764-0	2016	Curcumin reverses benzidine-induced cell proliferation by suppressing ERK1/2 pathway in human bladder cancer T24 cells.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	70-76
26776764-7	2016	Treatment with ERK1/2 inhibitor U0126 or curcumin effectively abrogated benzidine-triggered cell proliferation and ERK1/2/AP-1 activation.	Curcumin	41-49	mitogen-activated protein kinase 3	Homo sapiens	115-121
26776764-8	2016	These results suggested for the first time that curcumin in low concentrations played a protective role in benzidine-induced ERK1/2/AP-1 activation and proliferation of bladder cancer cells, therefore providing new insights into the pathogenesis and chemoprevention of benzidine-associated bladder cancer.	Curcumin	48-56	mitogen-activated protein kinase 3	Homo sapiens	125-131
27190933-12	2016	CONCLUSION: Our study conclude that curcumin inhibits the cancer cell growth by inducing apoptosis and enhance the therapeutic potential of TRAIL which recommends that both curcumin alone or in combination with TRAIL might be useful for leukaemic prevention and better therapeutic responses.	Curcumin	36-44	TNF superfamily member 10	Homo sapiens	140-145
27190933-12	2016	CONCLUSION: Our study conclude that curcumin inhibits the cancer cell growth by inducing apoptosis and enhance the therapeutic potential of TRAIL which recommends that both curcumin alone or in combination with TRAIL might be useful for leukaemic prevention and better therapeutic responses.	Curcumin	36-44	TNF superfamily member 10	Homo sapiens	211-216
27190933-12	2016	CONCLUSION: Our study conclude that curcumin inhibits the cancer cell growth by inducing apoptosis and enhance the therapeutic potential of TRAIL which recommends that both curcumin alone or in combination with TRAIL might be useful for leukaemic prevention and better therapeutic responses.	Curcumin	173-181	TNF superfamily member 10	Homo sapiens	140-145
27226186-25	2016	The expression of mRNA for TNF-alpha, COX-2 and iNOS was significantly increased (P &lt; 0.05) in vehicle-pretreated control rats exposed to WRS and significantly attenuated (P &lt; 0.05) by curcumin administered in graded dosages.	Curcumin	191-199	tumor necrosis factor	Rattus norvegicus	27-36
27226186-25	2016	The expression of mRNA for TNF-alpha, COX-2 and iNOS was significantly increased (P &lt; 0.05) in vehicle-pretreated control rats exposed to WRS and significantly attenuated (P &lt; 0.05) by curcumin administered in graded dosages.	Curcumin	191-199	nitric oxide synthase 2	Rattus norvegicus	48-52
26974552-0	2016	Correction: Curcumin Significantly Enhances Dual PI3K/Akt and mTOR Inhibitor NVP-BEZ235-Induced Apoptosis in Human Renal Carcinoma Caki Cells through Down-Regulation of p53-Dependent Bcl-2 Expression and Inhibition of Mcl-1 Protein Stability.	Curcumin	12-20	AKT serine/threonine kinase 1	Homo sapiens	54-57
26609559-8	2016	These findings enhance understanding of the actions of curcumin and suggest that the known hepatoprotective properties of curcumin are, at least in part, mediated through inhibition of TRPM2 channels.	Curcumin	122-130	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	185-190
26905192-6	2016	Alpha-smooth muscle actin (alpha-SMA) was significantly reduced, and insulin antibodies showed strong positive immunoreactivity with curcumin administration.	Curcumin	133-141	insulin	Homo sapiens	69-76
26732833-10	2016	RESULTS: Administration of curcumin decreased TNF-alpha, TNFR2, and caspase 8 without affecting TNFR1 levels.	Curcumin	27-35	tumor necrosis factor	Rattus norvegicus	46-55
26732833-12	2016	CONCLUSIONS: The cytoprotective role of curcumin relies on its ability to decrease the TNFR2 mRNA and enhance the antiapoptotic molecules RIP and TRAF2 to decrease the apoptotic pathway via decreasing the caspase 8.	Curcumin	40-48	Tnf receptor-associated factor 2	Rattus norvegicus	146-151
26609559-0	2016	Curcumin inhibits activation of TRPM2 channels in rat hepatocytes.	Curcumin	0-8	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	32-37
26609559-5	2016	We report here the identification of curcumin ((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), a natural plant-derived polyphenol in turmeric spice, as a novel inhibitor of TRPM2 channel.	Curcumin	37-45	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	195-200
26609559-5	2016	We report here the identification of curcumin ((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), a natural plant-derived polyphenol in turmeric spice, as a novel inhibitor of TRPM2 channel.	Curcumin	47-114	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	195-200
26609559-7	2016	Furthermore, in patch clamping experiments incubation of hepatocytes with curcumin inhibited activation of TRPM2 current by intracellular ADPR with IC50 of approximately 50nM.	Curcumin	74-82	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	107-112
27007499-3	2016	However, W1282X-CFTR channels were stimulated by two CFTR modulators, the FDA-approved VX-770 and the dietary compound curcumin.	Curcumin	119-127	CF transmembrane conductance regulator	Homo sapiens	16-20
27007499-3	2016	However, W1282X-CFTR channels were stimulated by two CFTR modulators, the FDA-approved VX-770 and the dietary compound curcumin.	Curcumin	119-127	CF transmembrane conductance regulator	Homo sapiens	53-57
27007499-7	2016	VX-770 and curcumin exerted additive effects on W1282X-CFTR channel gating (opening/closing) in excised patches such that the Po of the truncated channel approached unity (&gt; 0.9) when treated with both modulators.	Curcumin	11-19	CF transmembrane conductance regulator	Homo sapiens	55-59
27007499-8	2016	VX-770 and curcumin also additively stimulated W1282X-CFTR mediated currents in polarized FRT epithelial monolayers.	Curcumin	11-19	CF transmembrane conductance regulator	Homo sapiens	54-58
26873414-4	2016	Compounds 3e (IC50 2.75 muM), 3f (IC50 4.21 muM) and 3i (IC50 15.98 muM) showed better activity than the standard curcumin (IC50 23.54 muM) against A549 cell line.	Curcumin	114-122	latexin	Homo sapiens	24-27
26873414-4	2016	Compounds 3e (IC50 2.75 muM), 3f (IC50 4.21 muM) and 3i (IC50 15.98 muM) showed better activity than the standard curcumin (IC50 23.54 muM) against A549 cell line.	Curcumin	114-122	latexin	Homo sapiens	44-47
26873414-4	2016	Compounds 3e (IC50 2.75 muM), 3f (IC50 4.21 muM) and 3i (IC50 15.98 muM) showed better activity than the standard curcumin (IC50 23.54 muM) against A549 cell line.	Curcumin	114-122	latexin	Homo sapiens	44-47
26873414-4	2016	Compounds 3e (IC50 2.75 muM), 3f (IC50 4.21 muM) and 3i (IC50 15.98 muM) showed better activity than the standard curcumin (IC50 23.54 muM) against A549 cell line.	Curcumin	114-122	latexin	Homo sapiens	44-47
26974552-0	2016	Correction: Curcumin Significantly Enhances Dual PI3K/Akt and mTOR Inhibitor NVP-BEZ235-Induced Apoptosis in Human Renal Carcinoma Caki Cells through Down-Regulation of p53-Dependent Bcl-2 Expression and Inhibition of Mcl-1 Protein Stability.	Curcumin	12-20	mechanistic target of rapamycin kinase	Homo sapiens	62-66
26974552-0	2016	Correction: Curcumin Significantly Enhances Dual PI3K/Akt and mTOR Inhibitor NVP-BEZ235-Induced Apoptosis in Human Renal Carcinoma Caki Cells through Down-Regulation of p53-Dependent Bcl-2 Expression and Inhibition of Mcl-1 Protein Stability.	Curcumin	12-20	tumor protein p53	Homo sapiens	169-172
26974552-0	2016	Correction: Curcumin Significantly Enhances Dual PI3K/Akt and mTOR Inhibitor NVP-BEZ235-Induced Apoptosis in Human Renal Carcinoma Caki Cells through Down-Regulation of p53-Dependent Bcl-2 Expression and Inhibition of Mcl-1 Protein Stability.	Curcumin	12-20	BCL2 apoptosis regulator	Homo sapiens	183-188
27042000-3	2016	Curcumin is a potent inhibitor of NF-kappaB activation.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	34-43
27042000-5	2016	In this study, we presented a novel NF-kappaB inhibitor named Da0324, a synthetic asymmetric mono-carbonyl analog of curcumin.	Curcumin	117-125	nuclear factor kappa B subunit 1	Homo sapiens	36-45
26998027-6	2016	Curcumin, SB431542 (a TGF-betaR-Smad2 inhibitor) and SB203580 (a p38 inhibitor) were used to inhibit the stimulation by TGF-beta1.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	120-129
26992258-3	2016	Curcumin resumes HG depression of Wnt/beta-catenin signaling and alleviates HG induction of superoxide, TGF-beta1 and fibronectin expression in renal mesangial cell.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	104-113
26688832-0	2016	Curcumin Inhibits 3T3-L1 Preadipocyte Proliferation by Mechanisms Involving Post-transcriptional p27 Regulation.	Curcumin	0-8	zinc ribbon domain containing 2	Homo sapiens	97-100
26688832-3	2016	In addition, curcumin dose-dependently induced p27 protein accumulation and G1 arrest of synchronously replicating 3T3-L1 preadipocytes.	Curcumin	13-21	zinc ribbon domain containing 2	Homo sapiens	47-50
26688832-5	2016	In support of this hypothesis, curcumin markedly increased p27 protein half-life as well as attenuated ubiquitin proteasome activity suggesting that inhibition of targeted p27 proteolysis occurred through curcumin-mediated attenuation of Skp2 and 26S proteasome activity.	Curcumin	31-39	zinc ribbon domain containing 2	Homo sapiens	59-62
26688832-5	2016	In support of this hypothesis, curcumin markedly increased p27 protein half-life as well as attenuated ubiquitin proteasome activity suggesting that inhibition of targeted p27 proteolysis occurred through curcumin-mediated attenuation of Skp2 and 26S proteasome activity.	Curcumin	31-39	zinc ribbon domain containing 2	Homo sapiens	172-175
26688832-5	2016	In support of this hypothesis, curcumin markedly increased p27 protein half-life as well as attenuated ubiquitin proteasome activity suggesting that inhibition of targeted p27 proteolysis occurred through curcumin-mediated attenuation of Skp2 and 26S proteasome activity.	Curcumin	205-213	zinc ribbon domain containing 2	Homo sapiens	172-175
26688832-8	2016	Collectively, our data demonstrate that curcumin-mediated post-transcriptional accumulation of p27 accounts in part for the anti-proliferative effect observed in 3T3-L1 preadipocytes.	Curcumin	40-48	zinc ribbon domain containing 2	Homo sapiens	95-98
26674254-5	2016	The effective internalization of curcumin in cancer cells through the mesoporous silica materials initiated the generation of intracellular reactive oxygen species and the down regulation of poly ADP ribose polymerase (PARP) enzyme levels compared to free curcumin leading to the activation of apoptosis.	Curcumin	33-41	poly(ADP-ribose) polymerase 1	Homo sapiens	191-217
26674254-5	2016	The effective internalization of curcumin in cancer cells through the mesoporous silica materials initiated the generation of intracellular reactive oxygen species and the down regulation of poly ADP ribose polymerase (PARP) enzyme levels compared to free curcumin leading to the activation of apoptosis.	Curcumin	33-41	poly(ADP-ribose) polymerase 1	Homo sapiens	219-223
26639783-0	2016	Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling.	Curcumin	0-8	sirtuin 1	Rattus norvegicus	121-126
26992258-6	2016	Curcumin treatment reduced the TGF-beta1 and fibronectin activation and the inhibiting effect of diabetes on Wnt5a/beta-catenin expression in renal glomeruli.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	31-40
26992258-6	2016	Curcumin treatment reduced the TGF-beta1 and fibronectin activation and the inhibiting effect of diabetes on Wnt5a/beta-catenin expression in renal glomeruli.	Curcumin	0-8	Wnt family member 5A	Rattus norvegicus	109-114
26992258-7	2016	Immunohistochemistry showed that curcumin treatment significantly reduced 8-hydroxy-2"-deoxyguanosine, TGF-beta1 and fibronectin, and was in line with the restoration of the suppressed Wnt5a expression immunoreactivities in glomeruli of diabetic rats.	Curcumin	33-41	transforming growth factor, beta 1	Rattus norvegicus	103-112
26992258-7	2016	Immunohistochemistry showed that curcumin treatment significantly reduced 8-hydroxy-2"-deoxyguanosine, TGF-beta1 and fibronectin, and was in line with the restoration of the suppressed Wnt5a expression immunoreactivities in glomeruli of diabetic rats.	Curcumin	33-41	Wnt family member 5A	Rattus norvegicus	185-190
25918933-9	2016	There was no significant difference in nuclear factor-kappa B activity between the groups for three observations; however, in the curcumin group, c-Jun N-terminal kinase significantly decreased from the pre-ischaemia to the re-perfusion phases, and caspase-3 expression was lower in the ischaemia phase.	Curcumin	130-138	caspase 3	Homo sapiens	249-258
25918933-11	2016	CONCLUSION: Cardioprotective effects of curcumin may include inhibition of the c-Jun N-terminal kinase pathway and caspase-3 in cardiomyocytes, particularly in the ischaemia phase.	Curcumin	40-48	caspase 3	Homo sapiens	115-124
26998027-7	2016	The results demonstrated that the TGF-beta1-induced expression of alpha-SMA and ColI was suppressed by curcumin at the mRNA and protein levels, while SB431542 and SB203580 induced similar effects.	Curcumin	103-111	transforming growth factor, beta 1	Rattus norvegicus	34-43
26998027-8	2016	Furthermore, phosphorylated Smad-2 and p38 were upregulated in TGF-beta1-induced CFs, and these effects were substantially inhibited by curcumin administration.	Curcumin	136-144	transforming growth factor, beta 1	Rattus norvegicus	63-72
26998027-9	2016	In conclusion, the results of the present study demonstrated that treatment with curcumin effectively suppresses TGF-beta1-induced CF differentiation via Smad-2 and p38 signaling pathways.	Curcumin	81-89	transforming growth factor, beta 1	Rattus norvegicus	113-122
26781771-0	2016	Curcumin activates autophagy and attenuates oxidative damage in EA.hy926 cells via the Akt/mTOR pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	87-90
26937210-0	2016	Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF-alpha related mechanism.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	121-130
26937210-10	2016	Curcumin may protect the intestine from I/R injury through restoration of the epithelial structure, promotion of the recovery of intestinal permeability, as well as enhancement of ZO-1 protein expression, and this eff ect may be partly attributed to the TNF-alpha related pathway.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	254-263
26781771-0	2016	Curcumin activates autophagy and attenuates oxidative damage in EA.hy926 cells via the Akt/mTOR pathway.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	91-95
26781771-6	2016	Treatment with curcumin (5 or 20 micromol/l) significantly inhibited apoptosis, and reversed the alterations in caspase-3, Bcl-2 and Bax expression.	Curcumin	15-23	caspase 3	Homo sapiens	112-121
26781771-6	2016	Treatment with curcumin (5 or 20 micromol/l) significantly inhibited apoptosis, and reversed the alterations in caspase-3, Bcl-2 and Bax expression.	Curcumin	15-23	BCL2 apoptosis regulator	Homo sapiens	123-128
26781771-6	2016	Treatment with curcumin (5 or 20 micromol/l) significantly inhibited apoptosis, and reversed the alterations in caspase-3, Bcl-2 and Bax expression.	Curcumin	15-23	BCL2 associated X, apoptosis regulator	Homo sapiens	133-136
26833194-9	2016	Moreover, inhibition of Abl through ST571 treatment and its downstream effector JNK through SP600125 treatment blocked GADD45alpha upregulation and cell death triggered by curcumin.	Curcumin	172-180	mitogen-activated protein kinase 8	Homo sapiens	80-83
26781771-7	2016	Furthermore, curcumin induced autophagy and microtubule-associated protein 1A/1B-light chain 3-II expression, and suppressed the phosphorylation of Akt and mammalian target of rapamycin (mTOR).	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	148-151
26833194-10	2016	Collective results lead us to conclude that GADD45alpha modulates curcumin sensitivity through activation of c-Abl &gt; JNK signaling in a mismatch repair-dependent manner.	Curcumin	66-74	mitogen-activated protein kinase 8	Homo sapiens	120-123
26781771-7	2016	Furthermore, curcumin induced autophagy and microtubule-associated protein 1A/1B-light chain 3-II expression, and suppressed the phosphorylation of Akt and mammalian target of rapamycin (mTOR).	Curcumin	13-21	mechanistic target of rapamycin kinase	Homo sapiens	156-185
26781771-7	2016	Furthermore, curcumin induced autophagy and microtubule-associated protein 1A/1B-light chain 3-II expression, and suppressed the phosphorylation of Akt and mammalian target of rapamycin (mTOR).	Curcumin	13-21	mechanistic target of rapamycin kinase	Homo sapiens	187-191
26781771-8	2016	These results indicated that curcumin may protect cells against oxidative stress-induced damage through inhibiting apoptosis and inducing autophagy via the Akt/mTOR pathway.	Curcumin	29-37	AKT serine/threonine kinase 1	Homo sapiens	156-159
26781771-8	2016	These results indicated that curcumin may protect cells against oxidative stress-induced damage through inhibiting apoptosis and inducing autophagy via the Akt/mTOR pathway.	Curcumin	29-37	mechanistic target of rapamycin kinase	Homo sapiens	160-164
26583522-6	2016	Meanwhile, the results of fluorescence quenching, CD and three-dimensional fluorescence spectra revealed that flavonoids further strengthened the microenvironmental and conformational changes of HSA induced by CU binding.	Curcumin	210-212	albumin	Homo sapiens	195-198
26796031-1	2016	BACKGROUND: The aim of this study was to evaluate the effects of photodynamic therapy with curcumin (PDT) comparatively to 5% sodium hypochlorite (NaOCl) and saline solution on cell viability and cytokine (IL-1beta and IL-6) production by mouse fibroblasts.	Curcumin	91-99	interleukin 1 beta	Mus musculus	206-214
26796031-1	2016	BACKGROUND: The aim of this study was to evaluate the effects of photodynamic therapy with curcumin (PDT) comparatively to 5% sodium hypochlorite (NaOCl) and saline solution on cell viability and cytokine (IL-1beta and IL-6) production by mouse fibroblasts.	Curcumin	91-99	interleukin 6	Mus musculus	219-223
26490992-0	2016	Curcumin induces apoptosis in p53-null Hep3B cells through a TAp73/DNp73-dependent pathway.	Curcumin	0-8	tumor protein p53	Homo sapiens	30-33
26927554-0	2016	[Curcumin improves learning and memory function through decreasing hippocampal TNF-alpha and iNOS levels after subarachnoid hemorrhage in rats].	Curcumin	1-9	tumor necrosis factor	Rattus norvegicus	79-88
26927554-0	2016	[Curcumin improves learning and memory function through decreasing hippocampal TNF-alpha and iNOS levels after subarachnoid hemorrhage in rats].	Curcumin	1-9	nitric oxide synthase 2	Rattus norvegicus	93-97
26927554-12	2016	The levels of TNF-alpha and iNOS in the curcumin-treated group were significantly lower than those of the SAH group.	Curcumin	40-48	tumor necrosis factor	Rattus norvegicus	14-23
26927554-12	2016	The levels of TNF-alpha and iNOS in the curcumin-treated group were significantly lower than those of the SAH group.	Curcumin	40-48	nitric oxide synthase 2	Rattus norvegicus	28-32
26927554-14	2016	Curcumin can recover learning and memory function through down-regulating hippocampal TNF-alpha and iNOS levels.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	86-95
26927554-14	2016	Curcumin can recover learning and memory function through down-regulating hippocampal TNF-alpha and iNOS levels.	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	100-104
26915414-6	2016	Ingenuity Pathway Analysis(TM) (IPA) suggested that curcumin may exert its anticancer effects over multiple critical biological pathways including the EIF2, eIF4/p70S6K, mTOR signaling and mitochondrial dysfunction pathways.	Curcumin	52-60	eukaryotic translation initiation factor 2 subunit gamma	Homo sapiens	151-155
26915414-6	2016	Ingenuity Pathway Analysis(TM) (IPA) suggested that curcumin may exert its anticancer effects over multiple critical biological pathways including the EIF2, eIF4/p70S6K, mTOR signaling and mitochondrial dysfunction pathways.	Curcumin	52-60	mechanistic target of rapamycin kinase	Homo sapiens	170-174
26826337-0	2016	Curcumin inhibits metastasis in human papillary thyroid carcinoma BCPAP cells via down-regulation of the TGF-beta/Smad2/3 signaling pathway.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	105-113
26826337-5	2016	Herein, we demonstrated that curcumin remarkably increased the expression of the epithelial marker E-cadherin and repressed the expression of the mesenchymal marker vimentin in human papillary thyroid carcinoma BCPAP cells.	Curcumin	29-37	cadherin 1	Homo sapiens	99-109
26826337-7	2016	In addition, the transcription, secretion and activation of matrix metalloproteinases (MMPs) induced by transforming growth factor-beta1 (TGF-beta1) in BCPAP cells were mitigated upon curcumin treatment.	Curcumin	184-192	transforming growth factor beta 1	Homo sapiens	104-136
26826337-7	2016	In addition, the transcription, secretion and activation of matrix metalloproteinases (MMPs) induced by transforming growth factor-beta1 (TGF-beta1) in BCPAP cells were mitigated upon curcumin treatment.	Curcumin	184-192	transforming growth factor beta 1	Homo sapiens	138-147
26826337-8	2016	Further evidence showed that curcumin decreased TGF-beta1-mediated phosphorylation of Smad2 and Smad3.	Curcumin	29-37	transforming growth factor beta 1	Homo sapiens	48-57
26826337-9	2016	These results revealed that curcumin inhibited the TGF-beta1-induced epithelial-mesenchymal transition (EMT) via down-regulation of Smad2/3 signaling pathways.	Curcumin	28-36	transforming growth factor beta 1	Homo sapiens	51-60
26502886-7	2016	In Bcrp1 (-/-) mice, there was a further increase (6-fold increase) in AUC of resveratrol glucuronide observed when curcumin was co-administered compared to AUC values obtained in wild-type mice without curcumin treatment.	Curcumin	116-124	BAF nuclear assembly factor 1	Mus musculus	3-8
26502886-7	2016	In Bcrp1 (-/-) mice, there was a further increase (6-fold increase) in AUC of resveratrol glucuronide observed when curcumin was co-administered compared to AUC values obtained in wild-type mice without curcumin treatment.	Curcumin	203-211	BAF nuclear assembly factor 1	Mus musculus	3-8
26583522-0	2016	The increased binding affinity of curcumin with human serum albumin in the presence of rutin and baicalin: A potential for drug delivery system.	Curcumin	34-42	albumin	Homo sapiens	54-67
26583522-1	2016	The impacts of rutin and baicalin on the interaction of curcumin (CU) with human serum albumin (HSA) were investigated by fluorescence and circular dichroism (CD) spectroscopies under imitated physiological conditions.	Curcumin	56-64	albumin	Homo sapiens	81-94
26583522-1	2016	The impacts of rutin and baicalin on the interaction of curcumin (CU) with human serum albumin (HSA) were investigated by fluorescence and circular dichroism (CD) spectroscopies under imitated physiological conditions.	Curcumin	56-64	albumin	Homo sapiens	96-99
26583522-1	2016	The impacts of rutin and baicalin on the interaction of curcumin (CU) with human serum albumin (HSA) were investigated by fluorescence and circular dichroism (CD) spectroscopies under imitated physiological conditions.	Curcumin	66-68	albumin	Homo sapiens	81-94
26583522-1	2016	The impacts of rutin and baicalin on the interaction of curcumin (CU) with human serum albumin (HSA) were investigated by fluorescence and circular dichroism (CD) spectroscopies under imitated physiological conditions.	Curcumin	66-68	albumin	Homo sapiens	96-99
26583522-2	2016	The results showed that the fluorescence quenching of HSA by CU was a simultaneous static and dynamic quenching process, irrespective of the presence or absence of flavonoids.	Curcumin	61-63	albumin	Homo sapiens	54-57
26583522-3	2016	The binding constants between CU and HSA in the absence and presence of rutin and baicalin were 2.268x10(5)M(-1), 3.062x10(5)M(-1), and 3.271x10(5)M(-1), indicating that the binding affinity was increased in the case of two flavonoids.	Curcumin	30-32	albumin	Homo sapiens	37-40
26583522-5	2016	Combined with the fact that flavonoids and CU have the same binding site (site I), it can be concluded that they may simultaneously bind in different regions in site I, and formed a ternary complex of flavonoid-HSA-CU.	Curcumin	43-45	albumin	Homo sapiens	211-214
26583522-7	2016	Therefore, it is possible to develop a novel complex involving CU, flavonoid and HSA for CU delivery.	Curcumin	89-91	albumin	Homo sapiens	81-84
26170171-0	2016	Multispectroscopic Investigation of the Interaction Between two Ruthenium(II) Arene Complexes of Curcumin Analogs and Human Serum Albumin.	Curcumin	97-105	albumin	Homo sapiens	124-137
28053883-12	2017	Furthermore, curcumin treatments increased neuronal viability and attenuated the immunoreactivity for COX-2 and TNF-alpha, in the hippocampus in both protocols.	Curcumin	13-21	tumor necrosis factor	Rattus norvegicus	112-121
26170171-1	2016	The interaction between two ruthenium(II) arene complexes of curcumin analogs and human serum albumin (HSA) was systematically investigated by multispectroscopic techniques.	Curcumin	61-69	albumin	Homo sapiens	88-101
26515751-8	2016	In cultured primary osteoblasts, pretreatment with curcumin concentration-dependently decreased the number of Dex-induced apoptotic osteoblasts by down-regulating the ratio of Bax/Bcl-2 as well as the levels of cleaved caspase-3 and cleaved poly ADP-ribose polymerase (PARP).	Curcumin	51-59	BCL2, apoptosis regulator	Rattus norvegicus	180-185
26796279-0	2016	The inhibition of PI3K and NFkappaB promoted curcumin-induced cell cycle arrest at G2/M via altering polyamine metabolism in Bcl-2 overexpressing MCF-7 breast cancer cells.	Curcumin	45-53	nuclear factor kappa B subunit 1	Homo sapiens	27-35
26796279-0	2016	The inhibition of PI3K and NFkappaB promoted curcumin-induced cell cycle arrest at G2/M via altering polyamine metabolism in Bcl-2 overexpressing MCF-7 breast cancer cells.	Curcumin	45-53	BCL2 apoptosis regulator	Homo sapiens	125-130
26796279-4	2016	In this study, we investigated the role of curcumin in induction of cell cycle arrest via regulating of NFkappaB and polyamine biosynthesis in wt and Bcl-2+ MCF-7 cells.	Curcumin	43-51	nuclear factor kappa B subunit 1	Homo sapiens	104-112
26796279-4	2016	In this study, we investigated the role of curcumin in induction of cell cycle arrest via regulating of NFkappaB and polyamine biosynthesis in wt and Bcl-2+ MCF-7 cells.	Curcumin	43-51	BCL2 apoptosis regulator	Homo sapiens	150-155
26796279-8	2016	However, Bcl-2 overexpression prevented the inhibition of cell cycle associated proteins after curcumin treatment.	Curcumin	95-103	BCL2 apoptosis regulator	Homo sapiens	9-14
25596714-0	2016	Curcumin inhibits LPA-induced invasion by attenuating RhoA/ROCK/MMPs pathway in MCF7 breast cancer cells.	Curcumin	0-8	ras homolog family member A	Homo sapiens	54-58
26796279-9	2016	The combination of LY294002, PI3K inhibitor, and curcumin induced cell cycle arrest by decreasing CDK4, CDK2 and cyclin E2 in Bcl-2+ MCF-7 cells.	Curcumin	49-57	BCL2 apoptosis regulator	Homo sapiens	126-131
26796279-11	2016	Curcumin could suppress the nuclear transport of NFkappaB through decreasing the interaction of P-IkappaB-NFkappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	49-57
26796279-11	2016	Curcumin could suppress the nuclear transport of NFkappaB through decreasing the interaction of P-IkappaB-NFkappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	106-114
26796279-12	2016	The combination of wedelolactone, NFkappaB inhibitor, and curcumin acted different on SSAT expression in wt MCF-7 and Bcl-2+ MCF-7 cells.	Curcumin	58-66	BCL2 apoptosis regulator	Homo sapiens	118-123
26796279-13	2016	NFkappaB inhibition increased the SSAT after curcumin treatment in Bcl-2 overexpressed MCF-7 cells.	Curcumin	45-53	nuclear factor kappa B subunit 1	Homo sapiens	0-8
26796279-13	2016	NFkappaB inhibition increased the SSAT after curcumin treatment in Bcl-2 overexpressed MCF-7 cells.	Curcumin	45-53	BCL2 apoptosis regulator	Homo sapiens	67-72
26796279-14	2016	Inhibition of NFkappaB activity as well as suppression of ROS generation with NAC resulted in the partial relief of cells from G2/M checkpoint after curcumin treatment in wt MCF-7 cells.	Curcumin	149-157	nuclear factor kappa B subunit 1	Homo sapiens	14-22
26796279-15	2016	In conclusion, the potential role of curcumin in induction of cell cycle arrest is related with NFkappaB-regulated polyamine biosynthesis.	Curcumin	37-45	nuclear factor kappa B subunit 1	Homo sapiens	96-104
25596714-16	2016	Concurrently, RhoA and ROCK activities and expression levels of RhoA, ROCK1, ROCK2, MMP2 and MMP9 were down-regulated by curcumin in a concentration-dependent manner.	Curcumin	121-129	ras homolog family member A	Homo sapiens	14-18
25596714-16	2016	Concurrently, RhoA and ROCK activities and expression levels of RhoA, ROCK1, ROCK2, MMP2 and MMP9 were down-regulated by curcumin in a concentration-dependent manner.	Curcumin	121-129	ras homolog family member A	Homo sapiens	64-68
25596714-17	2016	In conclusion, RhoA/ROCK/MMPs pathway activation is involved in LPA-induced invasion in MCF-7 cells; curcumin inhibited LPA-induced invasion in MCF-7 cells by attenuating RhoA/ROCK/MMPs pathway.	Curcumin	101-109	ras homolog family member A	Homo sapiens	171-175
26515751-9	2016	Moreover, curcumin pretreatment activated extracellular signal regulated kinase (ERK) signalling in Dex-induced osteoblasts by up-regulating the expression level of p-ERK1/2.	Curcumin	10-18	Eph receptor B1	Rattus norvegicus	42-79
26515751-9	2016	Moreover, curcumin pretreatment activated extracellular signal regulated kinase (ERK) signalling in Dex-induced osteoblasts by up-regulating the expression level of p-ERK1/2.	Curcumin	10-18	Eph receptor B1	Rattus norvegicus	81-84
26515751-10	2016	Taken together, our study demonstrated that curcumin could ameliorate GIO by protecting osteoblasts from apoptosis, which was possibly related to the activation of the ERK pathway.	Curcumin	44-52	Eph receptor B1	Rattus norvegicus	168-171
26677102-6	2016	The results revealed that treatment with curcumin attenuated DXM-induced bone injury in femurs, increased the serum levels of osteocalcin and decreased the levels of CTX.	Curcumin	41-49	bone gamma-carboxyglutamate protein	Rattus norvegicus	126-137
26761722-0	2016	Intranasal curcumin ameliorates airway inflammation and obstruction by regulating MAPKinase activation (p38, Erk and JNK) and prostaglandin D2 release in murine model of asthma.	Curcumin	11-19	mitogen-activated protein kinase 1	Mus musculus	109-112
26761722-4	2016	The present study provides new insight towards anti-asthmatic potential of intranasal curcumin at lower doses (2.5 and 5.0 mg/kg) in Balb/c mice sensitized and challenged with ovalbumin (OVA) which is effective in inhibiting airway inflammation.	Curcumin	86-94	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	176-185
26761722-5	2016	These investigations suggest that intranasal curcumin (2.5 and 5.0 mg/kg) regulates airway inflammation and airway obstruction mainly by modulating cytokine levels (IL-4, 5, IFN-y and TNF-alpha) and sPLA2 activity thereby inhibiting PGD2 release and COX-2 expression.	Curcumin	45-53	tumor necrosis factor	Mus musculus	184-193
26761722-6	2016	Further, the suppression of p38 MAPK, ERK 42/44 and JNK54/56 activation elucidate the mechanism behind the inhibitory role of intranasal curcumin in asthma progression.	Curcumin	137-145	mitogen-activated protein kinase 1	Mus musculus	38-41
26676408-0	2016	Curcumin upregulates Nrf2 nuclear translocation and protects rat hepatic stellate cells against oxidative stress.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	21-25
26335543-0	2016	Effect of curcumin (Curcuma longa extract) on LPS-induced acute lung injury is mediated by the activation of AMPK.	Curcumin	10-18	toll-like receptor 4	Mus musculus	46-49
26335543-2	2016	The present study investigated whether curcumin could increase 5" adenosine monophosphate-activated protein kinase (AMPK) activity in macrophages and modulate the severity of lipopolysaccharide (LPS)-induced acute lung injury.	Curcumin	39-47	toll-like receptor 4	Mus musculus	195-198
26335543-8	2016	Curcumin also diminished the LPS-induced increase in phosphorylation of inhibitory kappaB-alpha and the production of tumor necrosis factor alpha (TNF-alpha), macrophage inflammatory protein (MIP)-2, and interleukin (IL)-6 by macrophages.	Curcumin	0-8	toll-like receptor 4	Mus musculus	29-32
26335543-8	2016	Curcumin also diminished the LPS-induced increase in phosphorylation of inhibitory kappaB-alpha and the production of tumor necrosis factor alpha (TNF-alpha), macrophage inflammatory protein (MIP)-2, and interleukin (IL)-6 by macrophages.	Curcumin	0-8	tumor necrosis factor	Mus musculus	147-156
26335543-9	2016	Systemic administration of curcumin significantly decreased the production of TNF-alpha, MIP-2, and IL-6 as well as neutrophil accumulation in bronchoalveolar lavage fluid, and also decreased pulmonary myeloperoxidase levels and the wet/dry weight ratio in mice subjected to LPS treatment.	Curcumin	27-35	tumor necrosis factor	Mus musculus	78-87
26335543-9	2016	Systemic administration of curcumin significantly decreased the production of TNF-alpha, MIP-2, and IL-6 as well as neutrophil accumulation in bronchoalveolar lavage fluid, and also decreased pulmonary myeloperoxidase levels and the wet/dry weight ratio in mice subjected to LPS treatment.	Curcumin	27-35	chemokine (C-X-C motif) ligand 2	Mus musculus	89-94
26335543-9	2016	Systemic administration of curcumin significantly decreased the production of TNF-alpha, MIP-2, and IL-6 as well as neutrophil accumulation in bronchoalveolar lavage fluid, and also decreased pulmonary myeloperoxidase levels and the wet/dry weight ratio in mice subjected to LPS treatment.	Curcumin	27-35	interleukin 6	Mus musculus	100-104
26335543-9	2016	Systemic administration of curcumin significantly decreased the production of TNF-alpha, MIP-2, and IL-6 as well as neutrophil accumulation in bronchoalveolar lavage fluid, and also decreased pulmonary myeloperoxidase levels and the wet/dry weight ratio in mice subjected to LPS treatment.	Curcumin	27-35	toll-like receptor 4	Mus musculus	275-278
26335543-10	2016	CONCLUSION: These results suggest that the protective effect of curcumin on LPS-induced acute lung injury is associated with AMPK activation.	Curcumin	64-72	toll-like receptor 4	Mus musculus	76-79
26691217-9	2016	Induction of CUGBP2 expression by curcumin resulted in the downregulation of HO-1 and COX-2 and strongly sensitized tumor cells to GEM treatment.	Curcumin	34-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-91
26618861-2	2016	Herein, we demonstrate that curcumin-encapsulated poly(lactide-co-glycolide) (PLGA) 50:50 nanoparticles (NPs-Cur 50:50) are able to prevent the phosphorylation of Akt and Tau proteins in SK-N-SH cells induced by H2O2 and display higher anti-inflammatory and antioxidant activities than free curcumin.	Curcumin	28-36	AKT serine/threonine kinase 1	Homo sapiens	163-166
25385666-0	2016	Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect?	Curcumin	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	61-65
25385666-2	2016	Curcumin is a phenolic compound with lipid regulatory, anti-oxidative, anti-inflammatory and anti-tumorigenic properties that is beneficial in defending against NASH and was recently proved to be an Nrf2 activator.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	199-203
25385666-3	2016	The aim of this study was to evaluate whether Nrf2 activation could be involved in NASH mitigation by curcumin.	Curcumin	102-110	NFE2 like bZIP transcription factor 2	Rattus norvegicus	46-50
25385666-5	2016	RESULTS: Curcumin administration led to lower degrees of hepatic steatosis and inflammation; lower levels of serum aminotransferases, lipids, and homeostasis model assessment of insulin resistance; and lower serum and hepatic contents of tumor necrosis factor-alpha (TNF-alpha), interleukin-6, and malondialdehyde.	Curcumin	9-17	tumor necrosis factor	Rattus norvegicus	238-265
25385666-5	2016	RESULTS: Curcumin administration led to lower degrees of hepatic steatosis and inflammation; lower levels of serum aminotransferases, lipids, and homeostasis model assessment of insulin resistance; and lower serum and hepatic contents of tumor necrosis factor-alpha (TNF-alpha), interleukin-6, and malondialdehyde.	Curcumin	9-17	tumor necrosis factor	Rattus norvegicus	267-276
25385666-5	2016	RESULTS: Curcumin administration led to lower degrees of hepatic steatosis and inflammation; lower levels of serum aminotransferases, lipids, and homeostasis model assessment of insulin resistance; and lower serum and hepatic contents of tumor necrosis factor-alpha (TNF-alpha), interleukin-6, and malondialdehyde.	Curcumin	9-17	interleukin 6	Rattus norvegicus	279-292
25385666-7	2016	Moreover, Nrf2 expression in liver cell nuclei was significantly higher in rats with curcumin.	Curcumin	85-93	NFE2 like bZIP transcription factor 2	Rattus norvegicus	10-14
25385666-8	2016	CONCLUSIONS: Curcumin can prevent and ameliorate NASH via lipid reduction, improve insulin resistance, improve anti-inflammatory, and have antioxidant effects, possibly related to its activation of Nrf2.	Curcumin	13-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	198-202
26648392-0	2016	Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt/Nrf2 pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	82-85
26648392-0	2016	Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt/Nrf2 pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	86-90
26648392-7	2016	Mechanistic studies demonstrated that curcumin significantly restored the expression levels of heme oxygenase-1 and NAD(P)H: quinone oxidoreductase 1, thus ameliorating ROT-induced damage in vivo, via the phosphorylation of Akt and nuclear factor erythroid 2-related factor 2 (Nrf2).	Curcumin	38-46	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	116-149
26648392-7	2016	Mechanistic studies demonstrated that curcumin significantly restored the expression levels of heme oxygenase-1 and NAD(P)H: quinone oxidoreductase 1, thus ameliorating ROT-induced damage in vivo, via the phosphorylation of Akt and nuclear factor erythroid 2-related factor 2 (Nrf2).	Curcumin	38-46	AKT serine/threonine kinase 1	Rattus norvegicus	224-227
26648392-7	2016	Mechanistic studies demonstrated that curcumin significantly restored the expression levels of heme oxygenase-1 and NAD(P)H: quinone oxidoreductase 1, thus ameliorating ROT-induced damage in vivo, via the phosphorylation of Akt and nuclear factor erythroid 2-related factor 2 (Nrf2).	Curcumin	38-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	232-275
26648392-7	2016	Mechanistic studies demonstrated that curcumin significantly restored the expression levels of heme oxygenase-1 and NAD(P)H: quinone oxidoreductase 1, thus ameliorating ROT-induced damage in vivo, via the phosphorylation of Akt and nuclear factor erythroid 2-related factor 2 (Nrf2).	Curcumin	38-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	277-281
26648392-8	2016	Further studies indicated that the Akt/Nrf2 signaling pathway was associated with the protective role of curcumin in ROT-treated rats.	Curcumin	105-113	AKT serine/threonine kinase 1	Rattus norvegicus	35-38
26648392-8	2016	Further studies indicated that the Akt/Nrf2 signaling pathway was associated with the protective role of curcumin in ROT-treated rats.	Curcumin	105-113	NFE2 like bZIP transcription factor 2	Rattus norvegicus	39-43
26648392-9	2016	Inhibiting the Akt/Nrf2 pathway using a lentiviral vector containing Nrf2-specific short hairpin RNA, or the phosphoinositide 3-kinase inhibitor LY294002, markedly reduced the expression levels of TH and GSH, ultimately attenuating the neuroprotective effects of curcumin against oxidative damage.	Curcumin	263-271	AKT serine/threonine kinase 1	Rattus norvegicus	15-18
26648392-9	2016	Inhibiting the Akt/Nrf2 pathway using a lentiviral vector containing Nrf2-specific short hairpin RNA, or the phosphoinositide 3-kinase inhibitor LY294002, markedly reduced the expression levels of TH and GSH, ultimately attenuating the neuroprotective effects of curcumin against oxidative damage.	Curcumin	263-271	NFE2 like bZIP transcription factor 2	Rattus norvegicus	19-23
26648392-9	2016	Inhibiting the Akt/Nrf2 pathway using a lentiviral vector containing Nrf2-specific short hairpin RNA, or the phosphoinositide 3-kinase inhibitor LY294002, markedly reduced the expression levels of TH and GSH, ultimately attenuating the neuroprotective effects of curcumin against oxidative damage.	Curcumin	263-271	NFE2 like bZIP transcription factor 2	Rattus norvegicus	69-73
26648392-10	2016	These results indicated that curcumin was able to significantly ameliorate ROT-induced dopaminergic neuronal oxidative damage in the SNpc of rats via activation of the Akt/Nrf2 signaling pathway.	Curcumin	29-37	AKT serine/threonine kinase 1	Rattus norvegicus	168-171
26648392-10	2016	These results indicated that curcumin was able to significantly ameliorate ROT-induced dopaminergic neuronal oxidative damage in the SNpc of rats via activation of the Akt/Nrf2 signaling pathway.	Curcumin	29-37	NFE2 like bZIP transcription factor 2	Rattus norvegicus	172-176
26707143-0	2016	Curcumin enhances the antitumor effect of ABT-737 via activation of the ROS-ASK1-JNK pathway in hepatocellular carcinoma cells.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	81-84
26676408-10	2016	Furthermore, treatment with curcumin significantly increased the nuclear expression levels of Nrf2.	Curcumin	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	94-98
26718769-7	2016	Curcumin stimulated a 3.6-fold increase of 18F-FDG uptake in MCF-7 cells, along with augmented hexokinase activity and lactate efflux.	Curcumin	0-8	hexokinase 1	Homo sapiens	95-105
26573768-0	2016	Curcumin induces autophagy, inhibits proliferation and invasion by downregulating AKT/mTOR signaling pathway in human melanoma cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	82-85
26573768-0	2016	Curcumin induces autophagy, inhibits proliferation and invasion by downregulating AKT/mTOR signaling pathway in human melanoma cells.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	86-90
26573768-7	2016	Furthermore, curcumin suppressed the activation of AKT, mTOR and P70S6K proteins.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	51-54
26718769-9	2016	Inhibiting this metabolic response with 2-deoxyglucose (2-DG) blocked curcumin-induced mTOR activation and resulted in a greater anti-proliferative effect.	Curcumin	70-78	mechanistic target of rapamycin kinase	Homo sapiens	87-91
26573768-7	2016	Furthermore, curcumin suppressed the activation of AKT, mTOR and P70S6K proteins.	Curcumin	13-21	mechanistic target of rapamycin kinase	Homo sapiens	56-60
26696252-0	2016	Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3beta Inhibitors.	Curcumin	19-27	beta-secretase 1	Homo sapiens	76-82
26893768-6	2016	Furthermore, curcumin was able to effectively inhibit the HGF-induced increase in the levels of vimentin by downregulating the expression of phosphorylated c-Met, extracellular signal-regulated kinase and Snail.	Curcumin	13-21	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	156-161
26893768-6	2016	Furthermore, curcumin was able to effectively inhibit the HGF-induced increase in the levels of vimentin by downregulating the expression of phosphorylated c-Met, extracellular signal-regulated kinase and Snail.	Curcumin	13-21	snail family transcriptional repressor 1	Homo sapiens	205-210
26893768-7	2016	In conclusion, the results of the present study demonstrated that curcumin was able to reverse HGF-induced EMT, possibly by inhibiting c-Met expression in DU145 prostate cancer cells.	Curcumin	66-74	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	135-140
26829121-6	2016	The anti-beta2GPI-induced TF activity in homogenates of carotid arteries and peritoneal macrophages from mice could significantly decrease after PDTC and/or Curcumin treatment, in which PDTC showed the strongest inhibitory effect, but combination of two inhibitors had no synergistic effect.	Curcumin	157-165	apolipoprotein H	Mus musculus	9-17
26829121-6	2016	The anti-beta2GPI-induced TF activity in homogenates of carotid arteries and peritoneal macrophages from mice could significantly decrease after PDTC and/or Curcumin treatment, in which PDTC showed the strongest inhibitory effect, but combination of two inhibitors had no synergistic effect.	Curcumin	157-165	coagulation factor III	Mus musculus	26-28
26829121-7	2016	Furthermore, anti-beta2GPI-induced expression of TF, VCAM-1, ICAM-1 and E-selectin in the aorta and expression of TF, IL-1beta, IL-6 and TNF-alpha in peritoneal macrophages of mice were also significantly attenuated by PDTC and/or Curcumin treatment.	Curcumin	231-239	apolipoprotein H	Mus musculus	18-26
26893768-0	2016	Curcumin mediates reversion of HGF-induced epithelial-mesenchymal transition via inhibition of c-Met expression in DU145 cells.	Curcumin	0-8	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	95-100
26824354-0	2016	Curcumin Ameliorates the Reduction Effect of PGE2 on Fibrillar beta-Amyloid Peptide (1-42)-Induced Microglial Phagocytosis through the Inhibition of EP2-PKA Signaling in N9 Microglial Cells.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	63-89
26824354-4	2016	Here, we explored the prostaglandin-E2 (PGE2)-related signaling pathway that involved in curcumin-mediated phagocytosis in fibrillar beta-amyloid peptide (1-42) (fAbeta42)-stimulated N9 cells.	Curcumin	89-97	amyloid beta precursor protein	Homo sapiens	133-159
26713546-6	2016	Curcumin administration lowered tumor necrosis factor alpha (TNF-alpha), C reactive protein (CRP) levels and downregulated the protein expression of cyclo-oxygenase 2 (COX-2), protein kinase theta (PKCtheta).	Curcumin	0-8	C-reactive protein	Rattus norvegicus	73-91
26713546-4	2016	Curcumin treatment attenuated the insulin resistance by decreasing IRS-1 serine phosphorylation and increasing IRS-1 tyrosine phosphorylation in the skeletal muscle of high fructose fed rats.	Curcumin	0-8	insulin receptor substrate 1	Rattus norvegicus	67-72
26713546-6	2016	Curcumin administration lowered tumor necrosis factor alpha (TNF-alpha), C reactive protein (CRP) levels and downregulated the protein expression of cyclo-oxygenase 2 (COX-2), protein kinase theta (PKCtheta).	Curcumin	0-8	C-reactive protein	Rattus norvegicus	93-96
26713546-4	2016	Curcumin treatment attenuated the insulin resistance by decreasing IRS-1 serine phosphorylation and increasing IRS-1 tyrosine phosphorylation in the skeletal muscle of high fructose fed rats.	Curcumin	0-8	insulin receptor substrate 1	Rattus norvegicus	111-116
26713546-6	2016	Curcumin administration lowered tumor necrosis factor alpha (TNF-alpha), C reactive protein (CRP) levels and downregulated the protein expression of cyclo-oxygenase 2 (COX-2), protein kinase theta (PKCtheta).	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	32-59
26902401-8	2016	The effect of curcumin on copper-induced MAPK activation and cell proliferation was determined in cell culture system.	Curcumin	14-22	mitogen-activated protein kinase 1	Mus musculus	41-45
26713546-6	2016	Curcumin administration lowered tumor necrosis factor alpha (TNF-alpha), C reactive protein (CRP) levels and downregulated the protein expression of cyclo-oxygenase 2 (COX-2), protein kinase theta (PKCtheta).	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	61-70
26529184-7	2016	Curcumin also exerted a nonspecific neuroprotective effect, reducing toxicities induced by a range of Abeta conformers, including monomeric, oligomeric, prefibrillar, and fibrillar Abeta.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	102-107
26529184-7	2016	Curcumin also exerted a nonspecific neuroprotective effect, reducing toxicities induced by a range of Abeta conformers, including monomeric, oligomeric, prefibrillar, and fibrillar Abeta.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	181-186
26529184-8	2016	The neuroprotective effect is possibly membrane-mediated, as curcumin reduced the extent of cell membrane permeabilization induced by Abeta aggregates.	Curcumin	61-69	amyloid beta precursor protein	Homo sapiens	134-139
26529184-9	2016	Taken together, our study shows that curcumin exerts its neuroprotective effect against Abeta induced toxicity through at least two concerted pathways, modifying the Abeta aggregation pathway toward the formation of nontoxic aggregates and ameliorating Abeta-induced toxicity possibly through a nonspecific pathway.	Curcumin	37-45	amyloid beta precursor protein	Homo sapiens	88-93
26529184-9	2016	Taken together, our study shows that curcumin exerts its neuroprotective effect against Abeta induced toxicity through at least two concerted pathways, modifying the Abeta aggregation pathway toward the formation of nontoxic aggregates and ameliorating Abeta-induced toxicity possibly through a nonspecific pathway.	Curcumin	37-45	amyloid beta precursor protein	Homo sapiens	166-171
26752181-1	2016	Previous studies have evidenced that the anticancer potential of curcumin (diferuloylmethane), a main yellow bioactive compound from plant turmeric was mediated by interfering with PI3K/Akt signaling.	Curcumin	65-73	AKT serine/threonine kinase 1	Homo sapiens	186-189
26505786-0	2016	Combinatorial Effects of Curcumin with an Anti-Neoplastic Agent on Head and Neck Squamous Cell Carcinoma Through the Regulation of EGFR-ERK1/2 and Apoptotic Signaling Pathways.	Curcumin	25-33	epidermal growth factor receptor	Homo sapiens	131-135
26505786-0	2016	Combinatorial Effects of Curcumin with an Anti-Neoplastic Agent on Head and Neck Squamous Cell Carcinoma Through the Regulation of EGFR-ERK1/2 and Apoptotic Signaling Pathways.	Curcumin	25-33	mitogen-activated protein kinase 3	Homo sapiens	136-142
26505786-6	2016	Treatment with 5-FU or DOX in combination with curcumin induced apoptosis by inhibiting Bcl-2 and increasing Bax, caspase-3, and poly-ADP ribose polymerase (PARP) in NT8e cells.	Curcumin	47-55	BCL2 apoptosis regulator	Homo sapiens	88-93
26505786-6	2016	Treatment with 5-FU or DOX in combination with curcumin induced apoptosis by inhibiting Bcl-2 and increasing Bax, caspase-3, and poly-ADP ribose polymerase (PARP) in NT8e cells.	Curcumin	47-55	BCL2 associated X, apoptosis regulator	Homo sapiens	109-112
26505786-6	2016	Treatment with 5-FU or DOX in combination with curcumin induced apoptosis by inhibiting Bcl-2 and increasing Bax, caspase-3, and poly-ADP ribose polymerase (PARP) in NT8e cells.	Curcumin	47-55	caspase 3	Homo sapiens	114-123
26505786-6	2016	Treatment with 5-FU or DOX in combination with curcumin induced apoptosis by inhibiting Bcl-2 and increasing Bax, caspase-3, and poly-ADP ribose polymerase (PARP) in NT8e cells.	Curcumin	47-55	poly(ADP-ribose) polymerase 1	Homo sapiens	129-155
26505786-6	2016	Treatment with 5-FU or DOX in combination with curcumin induced apoptosis by inhibiting Bcl-2 and increasing Bax, caspase-3, and poly-ADP ribose polymerase (PARP) in NT8e cells.	Curcumin	47-55	poly(ADP-ribose) polymerase 1	Homo sapiens	157-161
26505786-9	2016	In addition, curcumin exposure along with 5-FU or DOX inhibited cell proliferation through the downregulation of EGFR-ERK1/2 signaling molecules.	Curcumin	13-21	epidermal growth factor receptor	Homo sapiens	113-117
26505786-9	2016	In addition, curcumin exposure along with 5-FU or DOX inhibited cell proliferation through the downregulation of EGFR-ERK1/2 signaling molecules.	Curcumin	13-21	mitogen-activated protein kinase 3	Homo sapiens	118-124
26752181-0	2016	Curcumin Suppresses Proliferation and Migration of MDA-MB-231 Breast Cancer Cells through Autophagy-Dependent Akt Degradation.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	110-113
26752181-1	2016	Previous studies have evidenced that the anticancer potential of curcumin (diferuloylmethane), a main yellow bioactive compound from plant turmeric was mediated by interfering with PI3K/Akt signaling.	Curcumin	75-92	AKT serine/threonine kinase 1	Homo sapiens	186-189
26752181-3	2016	This study experimentally revealed that curcumin treatment reduced Akt protein expression in a dose- and time-dependent manner in MDA-MB-231 breast cancer cells, along with an activation of autophagy and suppression of ubiquitin-proteasome system (UPS) function.	Curcumin	40-48	AKT serine/threonine kinase 1	Homo sapiens	67-70
26752181-4	2016	The curcumin-reduced Akt expression, cell proliferation, and migration were prevented by genetic and pharmacological inhibition of autophagy but not by UPS inhibition.	Curcumin	4-12	AKT serine/threonine kinase 1	Homo sapiens	21-24
26752181-6	2016	Thus, these results indicate that curcumin-stimulated AMPK activity induces activation of the autophagy-lysosomal protein degradation pathway leading to Akt degradation and the subsequent suppression of proliferation and migration in breast cancer cell.	Curcumin	34-42	AKT serine/threonine kinase 1	Homo sapiens	153-156
26278546-3	2016	These cells were then exposed to different concentration of cytarabine and curcumin to find out IC50 values and also its effect on MDR genes like MDR1, BCRP, LRP and FLT3 by RT-PCR method.	Curcumin	75-83	ATP binding cassette subfamily B member 1	Homo sapiens	146-150
26792980-0	2016	Design, synthesis, and antihypertensive activity of curcumin-inspired compounds via ACE inhibition and vasodilation, along with a bioavailability study for possible benefit in cardiovascular diseases.	Curcumin	52-60	angiotensin I converting enzyme	Rattus norvegicus	84-87
32262808-3	2016	Herein, we functionalized beta-CD inside novel kinds of mesoporous silica or magnetic mesoporous silica as the physical binding sites for the model drug curcumin through an out-inside two step bifunctionalization process including a vacuum pumping recrystallization drug loading process.	Curcumin	153-161	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	26-33
26278546-3	2016	These cells were then exposed to different concentration of cytarabine and curcumin to find out IC50 values and also its effect on MDR genes like MDR1, BCRP, LRP and FLT3 by RT-PCR method.	Curcumin	75-83	LDL receptor related protein 1	Homo sapiens	158-161
26278546-3	2016	These cells were then exposed to different concentration of cytarabine and curcumin to find out IC50 values and also its effect on MDR genes like MDR1, BCRP, LRP and FLT3 by RT-PCR method.	Curcumin	75-83	fms related receptor tyrosine kinase 3	Homo sapiens	166-170
27644631-0	2016	Curcumin Induces Apoptosis in Pre-B Acute Lymphoblastic Leukemia Cell Lines Via PARP-1 Cleavage.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	80-86
26706937-5	2016	Curcumin and capsaicin treatments significantly reduced hepatic fat accumulation and leptin levels; liver fetuin-A expression was decreased significantly by the curcumin treatment.	Curcumin	161-169	alpha-2-HS-glycoprotein	Rattus norvegicus	106-114
26706937-7	2016	The suppression of hepatic fetuin-A expression is observed to be especially sensitive to curcumin.	Curcumin	89-97	alpha-2-HS-glycoprotein	Rattus norvegicus	27-35
27644631-5	2016	Curcumin-induced apoptosis of leukemia cells was mediated by PARP-1 cleavage.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	61-67
27644631-6	2016	An increased level of caspase-3, apoptosis inducing factor (AIF), cleaved PARP-1 and decreased level of Bcl2 was observed in leukemia cells after 24h of curcumin treatment.	Curcumin	153-161	caspase 3	Homo sapiens	22-31
27644631-6	2016	An increased level of caspase-3, apoptosis inducing factor (AIF), cleaved PARP-1 and decreased level of Bcl2 was observed in leukemia cells after 24h of curcumin treatment.	Curcumin	153-161	poly(ADP-ribose) polymerase 1	Homo sapiens	74-80
27221847-6	2016	The calculated average sensitivity of all cell lines of a particular subpanel toward the test agent showed that all the curcumin analogues showed maximum activity on leukemia cell lines with GI50 values between 0.23 and 2.67 muM.	Curcumin	120-128	latexin	Homo sapiens	225-228
27644631-6	2016	An increased level of caspase-3, apoptosis inducing factor (AIF), cleaved PARP-1 and decreased level of Bcl2 was observed in leukemia cells after 24h of curcumin treatment.	Curcumin	153-161	BCL2 apoptosis regulator	Homo sapiens	104-108
27644631-8	2016	Therefore, we conclude that curcumin induces apoptosis in leukemia cells via PARP-1 mediated caspase-3 dependent pathway and further may act as a potential chemo-sensitizing agent for doxorubicin.	Curcumin	28-36	poly(ADP-ribose) polymerase 1	Homo sapiens	77-83
27644631-8	2016	Therefore, we conclude that curcumin induces apoptosis in leukemia cells via PARP-1 mediated caspase-3 dependent pathway and further may act as a potential chemo-sensitizing agent for doxorubicin.	Curcumin	28-36	caspase 3	Homo sapiens	93-102
28234242-0	2016	Effect of curcumin on inhibiting atherogenesis by down-regulating lipocalin-2 expression in apolipoprotein E knockout mice.	Curcumin	10-18	apolipoprotein E	Mus musculus	92-108
28234242-4	2016	The aim of the study was to investigate whether curcumin could alleviate atherosclerosis in ApoE-/- mice by down-regulating LCN2 expression.	Curcumin	48-56	apolipoprotein E	Mus musculus	92-96
28234242-8	2016	CONCLUSIONS: Our findings indicate that dietary curcumin ameliorates western diet-induced atherosclerosis in ApoE-/- mice, which is related to LCN2 down-regulation, anti-hyperlipidemia effect as well as the inhibition of inflammation.	Curcumin	48-56	apolipoprotein E	Mus musculus	109-113
26531053-2	2016	In the present study, we showed that curcumin enhanced the sensitivity of the double-positive (CD166+/EpCAM+) CSC subpopulation in non-small cell lung cancer (NSCLC) cell lines (A549 and H2170) to cisplatin-induced apoptosis and inhibition of metastasis.	Curcumin	37-45	epithelial cell adhesion molecule	Homo sapiens	102-107
27595397-10	2016	RESULTS: Curcumin and KN93 significantly inhibited the activation of CaMKII/NF-kappaB signaling induced by diabetes or elevated glucose, and subsequently decreased the expression of VEGF, iNOS and ICAM-1.	Curcumin	9-17	nitric oxide synthase 2	Rattus norvegicus	188-192
26511089-5	2016	Flow cytometry results showed that the intracellular uptake of curcumin (50 muM) was enhanced through the physical mixing with [WR]5 by 5.7 folds compared to that of curcumin alone in human leukemia (CCRFCEM) cells after 3 h. When [WR]5 was conjugated with curcumin, the intracellular uptake was enhanced by 4 fold.	Curcumin	63-71	latexin	Homo sapiens	76-79
26511089-5	2016	Flow cytometry results showed that the intracellular uptake of curcumin (50 muM) was enhanced through the physical mixing with [WR]5 by 5.7 folds compared to that of curcumin alone in human leukemia (CCRFCEM) cells after 3 h. When [WR]5 was conjugated with curcumin, the intracellular uptake was enhanced by 4 fold.	Curcumin	166-174	latexin	Homo sapiens	76-79
26511089-5	2016	Flow cytometry results showed that the intracellular uptake of curcumin (50 muM) was enhanced through the physical mixing with [WR]5 by 5.7 folds compared to that of curcumin alone in human leukemia (CCRFCEM) cells after 3 h. When [WR]5 was conjugated with curcumin, the intracellular uptake was enhanced by 4 fold.	Curcumin	166-174	latexin	Homo sapiens	76-79
26467482-3	2016	The present study explored whether curcumin is able to prevent the cisplatin-induced fibrosis and decreased expression of the TJ and adherens junction (AJ) proteins occludin, claudin-2 and E-cadherin in cisplatin-induced nephrotoxicity.	Curcumin	35-43	claudin 2	Rattus norvegicus	175-184
26648459-0	2016	A novel curcumin derivative increases the cytotoxicity of raloxifene in estrogen receptor-negative breast cancer cell lines.	Curcumin	8-16	estrogen receptor 1	Homo sapiens	72-89
26648459-2	2016	Raloxifene and the 2nd generation curcumin derivative 2,6-bis(pyridin-4-ylmethylene)-cyclohexanone (RL91) have been shown to inhibit the growth of ER-negative breast cancer cells in vitro and in vivo.	Curcumin	34-42	estrogen receptor 1	Homo sapiens	147-149
26350520-0	2016	Curcumin delivered through bovine serum albumin/polysaccharides multilayered microcapsules.	Curcumin	0-8	albumin	Homo sapiens	34-47
26989696-0	2016	Curcumin Protects Neonatal Rat Cardiomyocytes against High Glucose-Induced Apoptosis via PI3K/Akt Signalling Pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	94-97
26989696-5	2016	In addition, treatment with curcumin remarkably suppressed the increased activity of Rac1, as well as the enhanced expression of gp91(phox) and p47(phox) induced by high glucose.	Curcumin	28-36	NSFL1 cofactor	Rattus norvegicus	144-147
26989696-7	2016	Furthermore, curcumin treatment markedly inhibited the reduced Bcl-2/Bax ratio elicited by high glucose exposure.	Curcumin	13-21	BCL2, apoptosis regulator	Rattus norvegicus	63-68
26437580-7	2016	Key transcription factors and other regulatory molecules (ERK, FN1, TNFSF12 and PI3K complex) activated in inflammation were down-regulated by dietary intervention with curcumin.	Curcumin	169-177	mitogen-activated protein kinase 1	Mus musculus	58-61
26456563-6	2016	Increased expression of UCP1 and other brown adipocyte-specific markers was possibly mediated by curcumin-induced activation of AMP-activated protein kinase (AMPK) based on the fact that inhibition of AMPK by dorsomorphin abolished expression of PRDM16, UCP1 and peroxisome proliferator-activated receptor gamma co-activator 1-alpha while the activator 5-Aminoimidazole-4-carboxamide ribonucleotide elevated expression of these brown marker proteins.	Curcumin	97-105	PPARG coactivator 1 alpha	Homo sapiens	263-332
26891593-2	2016	METHODS: Cells treated with curcumin-loaded BNNTs and stimulated with lipopolysaccharide were assessed for nitric oxide release and stimulation of IL-6 and TNF-alpha.	Curcumin	28-36	interleukin 6	Homo sapiens	147-151
26891593-2	2016	METHODS: Cells treated with curcumin-loaded BNNTs and stimulated with lipopolysaccharide were assessed for nitric oxide release and stimulation of IL-6 and TNF-alpha.	Curcumin	28-36	tumor necrosis factor	Homo sapiens	156-165
27297427-5	2016	Interestingly, curcumin significantly prevented the muscle proteolysis rate and down-regulated expression levels of two critical muscle-specific ubiquitin ligases (Atrogin-1 and MuRF-1).	Curcumin	15-23	F-box protein 32	Rattus norvegicus	164-173
27297427-5	2016	Interestingly, curcumin significantly prevented the muscle proteolysis rate and down-regulated expression levels of two critical muscle-specific ubiquitin ligases (Atrogin-1 and MuRF-1).	Curcumin	15-23	tripartite motif containing 63	Rattus norvegicus	178-184
27297427-7	2016	Moreover, the nuclear NF-kappaB/p65 protein abundance were also decreased by curcumin.	Curcumin	77-85	synaptotagmin 1	Rattus norvegicus	32-35
26442630-7	2016	Interestingly, ATM/ATR activation by curcumin induced phosphorylation of Chk2 (Thr68) followed by that of Cdc25C (Ser216) and Cdc2 (Tyr15), and Cyclin B1 accumulation.	Curcumin	37-45	ATR serine/threonine kinase	Homo sapiens	19-22
26989696-8	2016	Moreover, curcumin significantly increased Akt and GSK-3beta phosphorylation in cardiomyocytes treated with high glucose.	Curcumin	10-18	AKT serine/threonine kinase 1	Rattus norvegicus	43-46
26989696-10	2016	In conclusion, these results demonstrated that curcumin attenuated high glucose-induced cardiomyocyte apoptosis by inhibiting NADPH-mediated oxidative stress and this protective effect is most likely mediated by PI3K/Akt-related signalling pathway.	Curcumin	47-55	AKT serine/threonine kinase 1	Rattus norvegicus	217-220
26817244-7	2016	The detailed mechanism of these compounds showed that triptolide enhanced calcium restoration, curcumin inhibited ERK &amp; p-STAT3 pathways, ginkolide B inhibited Ras/MAPK pathway, and steviol activated AMPK, which inhibited CFTR channel and mTOR pathway in cell and mouse models of PKD.	Curcumin	95-103	mitogen-activated protein kinase 1	Mus musculus	114-117
26817244-7	2016	The detailed mechanism of these compounds showed that triptolide enhanced calcium restoration, curcumin inhibited ERK &amp; p-STAT3 pathways, ginkolide B inhibited Ras/MAPK pathway, and steviol activated AMPK, which inhibited CFTR channel and mTOR pathway in cell and mouse models of PKD.	Curcumin	95-103	signal transducer and activator of transcription 3	Mus musculus	126-131
27709232-9	2016	Glutamate transporter-1 protein expression is significantly reduced in the curcumin-treated rats.	Curcumin	75-83	solute carrier family 1 member 2	Rattus norvegicus	0-23
27709232-11	2016	SOD (17% and 32%), and catalase (19% and 24%) activities were increased in the curcumin-treated hippocampus and the cortex region respectively.	Curcumin	79-87	catalase	Rattus norvegicus	23-31
27709232-13	2016	The mRNA expression of NK-kB and TLR4 was significantly reduced following curcumin treatment.	Curcumin	74-82	toll-like receptor 4	Rattus norvegicus	33-37
25432891-4	2016	The results indicated that curcumin pre-treatment significantly suppressed H2O2-induced cytotoxicity, inhibited the loss of mitochondrial membrane potential (Deltapsim) through regulation of Bcl-2 family expression, and ultimately reversed H2O2-induced apoptotic cell death in PC12 cells.	Curcumin	27-35	BCL2, apoptosis regulator	Rattus norvegicus	191-196
25432891-6	2016	Moreover, curcumin markedly alleviated the dysregulation of the MAPK and AKT pathways induced by H2O2.	Curcumin	10-18	AKT serine/threonine kinase 1	Rattus norvegicus	73-76
28569571-11	2016	In conclusion, curcumin strongly induces modulator effects on TRPM2-mediated Ca2+ influx caused by ROS and caspase 3 and 9 processes in SH-SY5Y neuroblastoma cells.	Curcumin	15-23	caspase 3	Homo sapiens	107-116
26802648-8	2016	In conclusion, curcumin may act synergistically with the chemotherapeutic regimen FOLFOX in gastric cancer in vitro and in vivo by inducing apoptosis via Bcl/Bax-caspase 8,9-caspase 3 pathway.	Curcumin	15-23	BCL2 associated X, apoptosis regulator	Homo sapiens	158-161
26802648-8	2016	In conclusion, curcumin may act synergistically with the chemotherapeutic regimen FOLFOX in gastric cancer in vitro and in vivo by inducing apoptosis via Bcl/Bax-caspase 8,9-caspase 3 pathway.	Curcumin	15-23	caspase 3	Homo sapiens	174-183
26531053-5	2016	Furthermore, we found that curcumin enhanced the inhibitory effects of cisplatin on the highly migratory CD166+/EpCAM+ subpopulation, marked by a reduction in cell migration to 9 and 21% in the A549 and H2170 cells, respectively, indicating that curcumin may increase the sensitivity of CSCs to cisplatin-induced migratory inhibition.	Curcumin	27-35	epithelial cell adhesion molecule	Homo sapiens	112-117
26531053-7	2016	In conclusion, we provided novel evidence of the previously unknown therapeutic effects of curcumin, either alone or in combination with cisplatin on the inhibition of the CD166+/EpCAM+ subpopulation of NSCLC cell lines.	Curcumin	91-99	epithelial cell adhesion molecule	Homo sapiens	179-184
25716057-0	2016	Interaction between curcumin and human serum albumin in the presence of excipients and the effect of binding on curcumin photostability.	Curcumin	20-28	albumin	Homo sapiens	39-52
26881029-2	2016	Treatment with curcumin protected against high omega-3 PUFA and ethanol-induced hepatosteatosis and increase in liver injury markers, alanine aminotransferase, and aspartate aminotransferase.	Curcumin	15-23	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	164-190
27780170-0	2016	Curcumin (Diferulolylmethane) Reduces Transglutaminase 2 Overexpression Induced by Retinoic Acid in Human Nervous Cell Lines.	Curcumin	0-8	transglutaminase 2	Homo sapiens	38-56
27780170-7	2016	On the basis of these literature data, our objective was to analyze the effects of curcumin on TG2 expression in human nervous cell lines.	Curcumin	83-91	transglutaminase 2	Homo sapiens	95-98
27780170-8	2016	METHODS: Human nervous cell lines were treated with curcumin alone or in association with retinoic acid in order to induce TG2 overexpression.	Curcumin	52-60	transglutaminase 2	Homo sapiens	123-126
27780170-10	2016	RESULTS: Curcumin was able to downregulate the expression of TG2 in human nervous cell lines, which was also the case after treatment with retinoic acid.	Curcumin	9-17	transglutaminase 2	Homo sapiens	61-64
27780170-11	2016	CONCLUSIONS: These results suggest a possible use of curcumin in reducing TG2 overexpression in human nervous cells.	Curcumin	53-61	transglutaminase 2	Homo sapiens	74-77
25716057-1	2016	Curcumin (Cur) is known to bind to human serum albumin (HSA) which may lead to a reduced phototoxic effect of the compound in the presence of serum or saliva.	Curcumin	0-8	albumin	Homo sapiens	41-54
26672753-3	2015	As recorded by whole-cell patch-clamp, curcumin increased BK (alpha) and BK (alpha+beta1) currents in transfected HEK293 cells as well as the current density of BK in A7r5 smooth muscle cells in a dose-dependent manner.	Curcumin	39-47	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	77-88
26716989-6	2015	Metabolomic analysis revealed that metabolite profiles were clearly distinct between TNF-alpha-stimulated vs. the control group (not stimulated by TNF-alpha or curcumin).	Curcumin	160-168	tumor necrosis factor	Homo sapiens	85-94
26716989-7	2015	Treatment of FLS with curcumin showed that the metabolic perturbation by TNF-alpha could be reversed to that of the control group to a considerable extent.	Curcumin	22-30	tumor necrosis factor	Homo sapiens	73-82
26716989-8	2015	Curcumin-treated FLS had higher restoration of amino acid and fatty acid metabolism, as indicated by the prominent metabolic restoration of intermediates of amino acid and fatty acid metabolism, compared with that observed in TNF-alpha-stimulated FLS.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	226-235
26716989-9	2015	In particular, the abundance of glycine, citrulline, arachidonic acid, and saturated fatty acids in TNF-alpha-stimulated FLS was restored to the control level after treatment with curcumin, suggesting that the effect of curcumin on preventing joint inflammation may be elucidated with the levels of these metabolites.	Curcumin	180-188	tumor necrosis factor	Homo sapiens	100-109
26716989-9	2015	In particular, the abundance of glycine, citrulline, arachidonic acid, and saturated fatty acids in TNF-alpha-stimulated FLS was restored to the control level after treatment with curcumin, suggesting that the effect of curcumin on preventing joint inflammation may be elucidated with the levels of these metabolites.	Curcumin	220-228	tumor necrosis factor	Homo sapiens	100-109
27457236-3	2016	At the molecular level, inhibition of NF-kB, Akt/PI3K, and MAPK pathways and enhancement of p53 are among the most important anticancer alterations induced by curcumin.	Curcumin	159-167	AKT serine/threonine kinase 1	Homo sapiens	45-48
27457236-3	2016	At the molecular level, inhibition of NF-kB, Akt/PI3K, and MAPK pathways and enhancement of p53 are among the most important anticancer alterations induced by curcumin.	Curcumin	159-167	tumor protein p53	Homo sapiens	92-95
29227593-5	2016	Curcumin displayed the inhibitoryeffect on gene expression of AbetaPP, TNFalpha and IL6, which resulted in the decrease of the level of these twocytokines and Abeta40.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	71-79
29227593-5	2016	Curcumin displayed the inhibitoryeffect on gene expression of AbetaPP, TNFalpha and IL6, which resulted in the decrease of the level of these twocytokines and Abeta40.	Curcumin	0-8	interleukin 6	Homo sapiens	84-87
26672753-4	2015	By incubating with curcumin for 24 hours, the current density of exogenous BK (alpha) in HEK293 cells and the endogenous BK in A7r5 cells were both enhanced notably, though the steady-state activation of the channels did not shift significantly, except for BK (alpha+beta1).	Curcumin	19-27	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	261-272
26656720-0	2015	Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-kappab/MMPs Signaling Pathway.	Curcumin	0-8	adiponectin, C1Q and collagen domain containing	Homo sapiens	74-85
26585812-0	2015	Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	131-134
26585812-6	2015	We also reveal that curcumin suppressed phthalate-induced migration, invasion, and CSC-like cell maintenance through inhibition of the aryl hydrocarbon receptor/ERK/SK1/S1P3 signaling pathway.	Curcumin	20-28	mitogen-activated protein kinase 1	Homo sapiens	161-164
26656720-0	2015	Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-kappab/MMPs Signaling Pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	86-95
26656720-8	2015	Curcumin inhibited the migratory and invasive ability of A549 cells via the inhibition of adiponectin expression by blocking the adiponectin receptor 1.	Curcumin	0-8	adiponectin, C1Q and collagen domain containing	Homo sapiens	90-101
26656720-9	2015	Curcumin treatment also inhibited the in vivo tumor growth of A549 cells and adiponectin expression.	Curcumin	0-8	adiponectin, C1Q and collagen domain containing	Homo sapiens	77-88
26656720-11	2015	The effect of curcumin in decreasing the migratory and invasive ability of A549 cells by inhibiting adiponectin expression is probably mediated through NF-kappaB/MMP pathways.	Curcumin	14-22	adiponectin, C1Q and collagen domain containing	Homo sapiens	100-111
26656720-11	2015	The effect of curcumin in decreasing the migratory and invasive ability of A549 cells by inhibiting adiponectin expression is probably mediated through NF-kappaB/MMP pathways.	Curcumin	14-22	nuclear factor kappa B subunit 1	Homo sapiens	152-161
27259310-0	2015	Curcumin Promotes Cell Cycle Arrest and Inhibits Survival of Human Renal Cancer Cells by Negative Modulation of the PI3K/AKT Signaling Pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	121-124
26630272-5	2015	Effects of the alpha-tomatine and curcumin combination were associated with synergistic inhibition of NF-kappaB activity and a potent decrease in the expression of its downstream gene Bcl-2 in the cells.	Curcumin	34-42	BCL2 apoptosis regulator	Homo sapiens	184-189
26630272-6	2015	Moreover, strong decreases in the levels of phospho-Akt and phosphor-ERK1/2 were found in PC-3 cells treated with alpha-tomatine and curcumin in combination.	Curcumin	133-141	mitogen-activated protein kinase 3	Homo sapiens	69-75
26637852-0	2015	Novel Nanoscale Delivery Particles Encapsulated with Anticancer Drugs, All-trans Retinoic Acid or Curcumin, Enhance Apoptosis in Lymphoma Cells Predominantly Expressing CD20 Antigen.	Curcumin	98-106	keratin 20	Homo sapiens	169-173
26554539-3	2015	The evaluation of the antioxidant activity of these compounds, based on DPPH, FRAP, and beta-carotene bleaching assays, showed that several of these azoles are better antioxidants than curcumin, with the isoxazole derivative 2g being overall the best.	Curcumin	185-193	mechanistic target of rapamycin kinase	Homo sapiens	78-82
26298484-0	2015	Curcumin promotes fibril formation in F isomer of human serum albumin via amorphous aggregation.	Curcumin	0-8	albumin	Homo sapiens	56-69
27259310-6	2015	In addition, curcumin decreased activation of the PI3K/AKT signaling pathway.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	55-58
27259310-7	2015	In conclusion, our results demonstrate that curcumin exerts anti-cancer effects by negative modulation of the PI3K/AKT signaling pathway and may represent a promising new drug to treat RCC.	Curcumin	44-52	AKT serine/threonine kinase 1	Homo sapiens	115-118
26395192-0	2015	Curcumin protects against fructose-induced podocyte insulin signaling impairment through upregulation of miR-206.	Curcumin	0-8	microRNA 206	Rattus norvegicus	105-112
26350251-0	2015	Curcumin enhances poly(ADP-ribose) polymerase inhibitor sensitivity to chemotherapy in breast cancer cells.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	18-45
26350251-5	2015	Curcumin also directly reduces HR and induces cell death with cotreatment of PARP inhibitor in MDA-MB-231 breast cancer cells.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	77-81
25143335-0	2015	Effects of curcumin on angiotensin-converting enzyme gene expression, oxidative stress and anti-oxidant status in thioacetamide-induced hepatotoxicity.	Curcumin	11-19	angiotensin I converting enzyme	Rattus norvegicus	23-52
25143335-1	2015	INTRODUCTION: This study aimed to evaluate the protective effects of curcumin on angiotensin-converting enzyme (ACE) gene expression, oxidative stress and anti-oxidant status in thioacetamide (TAA)-induced hepatotoxicity in rats.	Curcumin	69-77	angiotensin I converting enzyme	Rattus norvegicus	81-110
25143335-1	2015	INTRODUCTION: This study aimed to evaluate the protective effects of curcumin on angiotensin-converting enzyme (ACE) gene expression, oxidative stress and anti-oxidant status in thioacetamide (TAA)-induced hepatotoxicity in rats.	Curcumin	69-77	angiotensin I converting enzyme	Rattus norvegicus	112-115
25143335-11	2015	Treatment with curcumin suppressed ACE expression in TAA liver and reversed the toxicity produced.	Curcumin	15-23	angiotensin I converting enzyme	Rattus norvegicus	35-38
26456836-0	2015	Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-kappaB activation.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
26456836-11	2015	Curcumin also inhibited superoxide anion-induced leukocyte recruitment in the peritoneal cavity and in the paw skin inhibited myeloperoxidase activity, oxidative stress, IL-1beta and TNF-alpha production and NF-kappaB activation as well as enhanced IL-10 production, and HO-1 and Nrf2 mRNA expression.	Curcumin	0-8	myeloperoxidase	Homo sapiens	126-141
26456836-11	2015	Curcumin also inhibited superoxide anion-induced leukocyte recruitment in the peritoneal cavity and in the paw skin inhibited myeloperoxidase activity, oxidative stress, IL-1beta and TNF-alpha production and NF-kappaB activation as well as enhanced IL-10 production, and HO-1 and Nrf2 mRNA expression.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	170-178
26456836-11	2015	Curcumin also inhibited superoxide anion-induced leukocyte recruitment in the peritoneal cavity and in the paw skin inhibited myeloperoxidase activity, oxidative stress, IL-1beta and TNF-alpha production and NF-kappaB activation as well as enhanced IL-10 production, and HO-1 and Nrf2 mRNA expression.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	183-192
26456836-11	2015	Curcumin also inhibited superoxide anion-induced leukocyte recruitment in the peritoneal cavity and in the paw skin inhibited myeloperoxidase activity, oxidative stress, IL-1beta and TNF-alpha production and NF-kappaB activation as well as enhanced IL-10 production, and HO-1 and Nrf2 mRNA expression.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	280-284
26499200-0	2015	Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1alpha signaling.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	92-96
26499200-0	2015	Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1alpha signaling.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-107
26499200-6	2015	However, curcumin abrogated CAF-induced invasion and EMT, and inhibited ROS production and CXCR4 and IL-6 receptor expression in prostate cancer cells through inhibiting MAOA/mTOR/HIF-1alpha signaling, thereby supporting the therapeutic effect of curcumin in prostate cancer.	Curcumin	9-17	mechanistic target of rapamycin kinase	Homo sapiens	175-179
26499200-6	2015	However, curcumin abrogated CAF-induced invasion and EMT, and inhibited ROS production and CXCR4 and IL-6 receptor expression in prostate cancer cells through inhibiting MAOA/mTOR/HIF-1alpha signaling, thereby supporting the therapeutic effect of curcumin in prostate cancer.	Curcumin	9-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	180-190
26375757-3	2015	METHODS AND RESULTS: Curcumin inhibited vascular endothelial growth factor-C (VEGF-C) induced lymphangiogenesis in a Matrigel plug assay in mice, and VEGF-C induced tube formation in human dermal lymphatic endothelial cells, demonstrating its antilymphangiogenic action in vivo and in vitro.	Curcumin	21-29	vascular endothelial growth factor C	Mus musculus	40-76
26375757-3	2015	METHODS AND RESULTS: Curcumin inhibited vascular endothelial growth factor-C (VEGF-C) induced lymphangiogenesis in a Matrigel plug assay in mice, and VEGF-C induced tube formation in human dermal lymphatic endothelial cells, demonstrating its antilymphangiogenic action in vivo and in vitro.	Curcumin	21-29	vascular endothelial growth factor C	Mus musculus	78-84
26395192-5	2015	Curcumin significantly alleviated fructose-induced podocyte injury and proteinuria, miR-206 low-expression, protein tyrosine phosphatase 1B (PTP1B) overexpression, as well as downregulation of insulin receptor, insulin receptor substrate 1, caveolin-1, protein kinase B, and extracellular signal-regulated kinases 1 and 2 phosphorylation in kidney cortex or glomeruli of fructose-fed rats.	Curcumin	0-8	microRNA 206	Rattus norvegicus	84-91
26395192-5	2015	Curcumin significantly alleviated fructose-induced podocyte injury and proteinuria, miR-206 low-expression, protein tyrosine phosphatase 1B (PTP1B) overexpression, as well as downregulation of insulin receptor, insulin receptor substrate 1, caveolin-1, protein kinase B, and extracellular signal-regulated kinases 1 and 2 phosphorylation in kidney cortex or glomeruli of fructose-fed rats.	Curcumin	0-8	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	108-139
26395192-5	2015	Curcumin significantly alleviated fructose-induced podocyte injury and proteinuria, miR-206 low-expression, protein tyrosine phosphatase 1B (PTP1B) overexpression, as well as downregulation of insulin receptor, insulin receptor substrate 1, caveolin-1, protein kinase B, and extracellular signal-regulated kinases 1 and 2 phosphorylation in kidney cortex or glomeruli of fructose-fed rats.	Curcumin	0-8	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	141-146
26496980-8	2015	Numerous pathways, including p53, c-Jun N-terminal kinases (JNK), Akt and extracellular signal-regulated kinases (ERK)1/2 pathways were markedly altered following treatment of THP-1 cells with curcumin and naringenin.	Curcumin	193-201	tumor protein p53	Homo sapiens	29-32
26496980-8	2015	Numerous pathways, including p53, c-Jun N-terminal kinases (JNK), Akt and extracellular signal-regulated kinases (ERK)1/2 pathways were markedly altered following treatment of THP-1 cells with curcumin and naringenin.	Curcumin	193-201	AKT serine/threonine kinase 1	Homo sapiens	66-69
26395192-5	2015	Curcumin significantly alleviated fructose-induced podocyte injury and proteinuria, miR-206 low-expression, protein tyrosine phosphatase 1B (PTP1B) overexpression, as well as downregulation of insulin receptor, insulin receptor substrate 1, caveolin-1, protein kinase B, and extracellular signal-regulated kinases 1 and 2 phosphorylation in kidney cortex or glomeruli of fructose-fed rats.	Curcumin	0-8	caveolin 1	Rattus norvegicus	241-251
26496980-8	2015	Numerous pathways, including p53, c-Jun N-terminal kinases (JNK), Akt and extracellular signal-regulated kinases (ERK)1/2 pathways were markedly altered following treatment of THP-1 cells with curcumin and naringenin.	Curcumin	193-201	mitogen-activated protein kinase 3	Homo sapiens	74-121
26496980-9	2015	These results indicated that naringenin may enhance curcumin-induced apoptosis through inhibiting the Akt and ERK pathways, and promoting the JNK and p53 pathways.	Curcumin	52-60	AKT serine/threonine kinase 1	Homo sapiens	102-105
26496980-9	2015	These results indicated that naringenin may enhance curcumin-induced apoptosis through inhibiting the Akt and ERK pathways, and promoting the JNK and p53 pathways.	Curcumin	52-60	mitogen-activated protein kinase 1	Homo sapiens	110-113
26496980-9	2015	These results indicated that naringenin may enhance curcumin-induced apoptosis through inhibiting the Akt and ERK pathways, and promoting the JNK and p53 pathways.	Curcumin	52-60	tumor protein p53	Homo sapiens	150-153
26395192-7	2015	CONCLUSION: Curcumin is suggested to activate miR-206 expression to downregulate PTP1B, and then improve insulin signaling, protect against fructose-induced glomerular podocyte injury, and proteinuria, which may provide new evidence regarding curcumin"s effects on fructose-associated podocyte injury.	Curcumin	12-20	microRNA 206	Rattus norvegicus	46-53
26395192-7	2015	CONCLUSION: Curcumin is suggested to activate miR-206 expression to downregulate PTP1B, and then improve insulin signaling, protect against fructose-induced glomerular podocyte injury, and proteinuria, which may provide new evidence regarding curcumin"s effects on fructose-associated podocyte injury.	Curcumin	12-20	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	81-86
26395192-7	2015	CONCLUSION: Curcumin is suggested to activate miR-206 expression to downregulate PTP1B, and then improve insulin signaling, protect against fructose-induced glomerular podocyte injury, and proteinuria, which may provide new evidence regarding curcumin"s effects on fructose-associated podocyte injury.	Curcumin	243-251	microRNA 206	Rattus norvegicus	46-53
29124231-1	2015	The phytochemical curcumin may improve translocation of the cystic fibrosis transmembrane regulatory (CFTR) protein in lung epithelium and therefore be helpful in the treatment of cystic fibrosis (CF) symptoms.	Curcumin	18-26	CF transmembrane conductance regulator	Homo sapiens	60-100
26515460-0	2015	Effects of curcumin in pediatric epithelial liver tumors: inhibition of tumor growth and alpha-fetoprotein in vitro and in vivo involving the NFkappaB- and the beta-catenin pathways.	Curcumin	11-19	alpha fetoprotein	Homo sapiens	89-106
26515460-0	2015	Effects of curcumin in pediatric epithelial liver tumors: inhibition of tumor growth and alpha-fetoprotein in vitro and in vivo involving the NFkappaB- and the beta-catenin pathways.	Curcumin	11-19	nuclear factor kappa B subunit 1	Homo sapiens	142-150
26648693-2	2015	This study tested the hypothesis that inhibition of myocardial fibrosis by curcumin is associated with modulating expression of angiotensin II (Ang II) receptors and angiotensin-converting enzyme 2 (ACE2).	Curcumin	75-83	angiotensinogen	Rattus norvegicus	144-150
26648693-5	2015	The protein level of the Ang II type 1 (AT1) receptor was reduced, and the Ang II type 2 (AT2) receptor was up-regulated, evidenced by an increased ratio of the AT2 receptor over the AT1 receptor in the curcumin group (1.2+-0.02%) vs in the Ang II group (0.7+-0.03%, P&lt;0.05).	Curcumin	203-211	angiotensinogen	Rattus norvegicus	25-31
26648693-5	2015	The protein level of the Ang II type 1 (AT1) receptor was reduced, and the Ang II type 2 (AT2) receptor was up-regulated, evidenced by an increased ratio of the AT2 receptor over the AT1 receptor in the curcumin group (1.2+-0.02%) vs in the Ang II group (0.7+-0.03%, P&lt;0.05).	Curcumin	203-211	angiotensinogen	Rattus norvegicus	75-81
26648693-5	2015	The protein level of the Ang II type 1 (AT1) receptor was reduced, and the Ang II type 2 (AT2) receptor was up-regulated, evidenced by an increased ratio of the AT2 receptor over the AT1 receptor in the curcumin group (1.2+-0.02%) vs in the Ang II group (0.7+-0.03%, P&lt;0.05).	Curcumin	203-211	angiotensinogen	Rattus norvegicus	75-81
26648693-7	2015	Along with these modulations, curcumin significantly decreased the populations of macrophages and alpha smooth muscle actin-expressing myofibroblasts, which were accompanied by reduced expression of transforming growth factor beta 1 and phosphorylated-Smad2/3.	Curcumin	30-38	transforming growth factor, beta 1	Rattus norvegicus	199-232
26648693-9	2015	Furthermore, curcumin increased protein level of ACE2 and enhanced its expression in the intermyocardium relative to the Ang II group.	Curcumin	13-21	angiotensinogen	Rattus norvegicus	121-127
26648693-10	2015	These results suggest that curcumin could be considered as an add-on therapeutic agent in the treatment of fibrosis-derived heart failure patient who is intolerant of ACE inhibitor therapy.	Curcumin	27-35	angiotensin I converting enzyme	Homo sapiens	167-170
26397387-0	2015	Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	82-87
26397387-6	2015	Moreover, by molecular docking analysis and tumor sphere assay we discover that curcumin was able to inhibit JAK2 activity and reduce tumor spheres via inhibiting the JAK2/STAT3 signaling pathway.	Curcumin	80-88	signal transducer and activator of transcription 3	Homo sapiens	172-177
26633463-3	2015	Recent studies indicate that many natural products like curcumin, resveratrol and silymarin alter cellular metabolism and signal transduction pathways via enzymes such as adenosine monophosphate kinase (AMPK) and mechanistic target of rapamycin (mTOR), and these pathways directly influence cellular inflammatory status (such as NF-kappaB) and immune function.	Curcumin	56-64	mechanistic target of rapamycin kinase	Homo sapiens	213-244
26633463-3	2015	Recent studies indicate that many natural products like curcumin, resveratrol and silymarin alter cellular metabolism and signal transduction pathways via enzymes such as adenosine monophosphate kinase (AMPK) and mechanistic target of rapamycin (mTOR), and these pathways directly influence cellular inflammatory status (such as NF-kappaB) and immune function.	Curcumin	56-64	mechanistic target of rapamycin kinase	Homo sapiens	246-250
26608647-8	2015	While co-incubation with hCG along with several TLR ligands mediated heightened chemo-resistance, TLR-2/6 and TLR-9 ligands increased the phosphorylation of JNK, and TLR-2 and TLR-8 ligands the phosphorylation of ERK in presence of hCG and curcumin, providing evidence of tri-molecular synergy.	Curcumin	240-248	toll like receptor 2	Homo sapiens	98-105
26608647-8	2015	While co-incubation with hCG along with several TLR ligands mediated heightened chemo-resistance, TLR-2/6 and TLR-9 ligands increased the phosphorylation of JNK, and TLR-2 and TLR-8 ligands the phosphorylation of ERK in presence of hCG and curcumin, providing evidence of tri-molecular synergy.	Curcumin	240-248	toll like receptor 2	Homo sapiens	98-103
26469832-3	2015	This paper focuses on curcumin as an adjuvant molecule to cisplatin by analysing its potential implications on the molecular targets, signal transducer and activator of transcription 3 (STAT3) and NF-E2 p45-related factor 2 (Nrf-2), in tumour progression and cisplatin resistance in vitro and the adverse effect ototoxicity in vivo.	Curcumin	22-30	NFE2 like bZIP transcription factor 2	Rattus norvegicus	197-223
26469832-3	2015	This paper focuses on curcumin as an adjuvant molecule to cisplatin by analysing its potential implications on the molecular targets, signal transducer and activator of transcription 3 (STAT3) and NF-E2 p45-related factor 2 (Nrf-2), in tumour progression and cisplatin resistance in vitro and the adverse effect ototoxicity in vivo.	Curcumin	22-30	NFE2 like bZIP transcription factor 2	Rattus norvegicus	225-230
26469832-5	2015	RESULTS: This study demonstrates that curcumin attenuates all stages of tumour progression (survival, proliferation) and, by targeting pSTAT3 and Nrf-2 signalling pathways, provides chemosensitisation to cisplatin in vitro and protection from its ototoxic adverse effects in vivo.	Curcumin	38-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	146-151
26407474-10	2015	SIGNIFICANCE: The major finding of the study is that curcumin restored the core and associated symptoms of autistic phenotype by suppressing oxidative-nitrosative stress, mitochondrial dysfunction, TNF-alpha and MMP-9 in PPA-induced autism in rats.	Curcumin	53-61	tumor necrosis factor	Rattus norvegicus	198-207
29124231-1	2015	The phytochemical curcumin may improve translocation of the cystic fibrosis transmembrane regulatory (CFTR) protein in lung epithelium and therefore be helpful in the treatment of cystic fibrosis (CF) symptoms.	Curcumin	18-26	CF transmembrane conductance regulator	Homo sapiens	102-106
26330141-0	2015	Curcumin attenuates palmitate-induced apoptosis in MIN6 pancreatic beta-cells through PI3K/Akt/FoxO1 and mitochondrial survival pathways.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	91-94
26330141-7	2015	Curcumin treatment inhibited palmitate-induced apoptosis, relieved mitochondrial depolarization and up-regulated Bcl-2/Bax ratio.	Curcumin	0-8	B cell leukemia/lymphoma 2	Mus musculus	113-118
26330141-9	2015	Moreover, curcumin could promote rapid phosphorylation of Akt and nuclear exclusion of FoxO1 in MIN6 cells under lipotoxic condition.	Curcumin	10-18	thymoma viral proto-oncogene 1	Mus musculus	58-61
26330141-10	2015	Phosphatidylinositol 3-kinase and Akt specific inhibitors abolished the anti-lipotoxic effect of curcumin and stimulated FoxO1 nuclear translocation.	Curcumin	97-105	thymoma viral proto-oncogene 1	Mus musculus	34-37
26330141-11	2015	These findings suggested that curcumin protected MIN6 pancreatic beta-Cells against apoptosis through activation of Akt, inhibition of nuclear translocation of FoxO1 and mitochondrial survival pathway.	Curcumin	30-38	thymoma viral proto-oncogene 1	Mus musculus	116-119
25716014-8	2015	mRNA and protein expression of caspase-3 and caspase-9 and proapoptotic genes was increased in cells treated with a combination of curcumin and carboplatin, whereas expression of the antiapoptotic Bcl-2 gene was suppressed.	Curcumin	131-139	caspase 3	Homo sapiens	31-40
26232616-0	2015	Ceramide generation during curcumin-induced apoptosis is controlled by crosstalk among Bcl-2, Bcl-xL, caspases and glutathione.	Curcumin	27-35	BCL2 apoptosis regulator	Homo sapiens	87-92
26232616-0	2015	Ceramide generation during curcumin-induced apoptosis is controlled by crosstalk among Bcl-2, Bcl-xL, caspases and glutathione.	Curcumin	27-35	BCL2 like 1	Homo sapiens	94-100
26232616-5	2015	These data place nSMase activation downstream of caspase-8 and Bcl-xL and indicate a mutual regulation between nSMase and caspase-3 activity on one hand, and Bcl-2 level on the other hand in curcumin-treated cells.	Curcumin	191-199	BCL2 like 1	Homo sapiens	63-69
26232616-5	2015	These data place nSMase activation downstream of caspase-8 and Bcl-xL and indicate a mutual regulation between nSMase and caspase-3 activity on one hand, and Bcl-2 level on the other hand in curcumin-treated cells.	Curcumin	191-199	caspase 3	Homo sapiens	122-131
26232616-5	2015	These data place nSMase activation downstream of caspase-8 and Bcl-xL and indicate a mutual regulation between nSMase and caspase-3 activity on one hand, and Bcl-2 level on the other hand in curcumin-treated cells.	Curcumin	191-199	BCL2 apoptosis regulator	Homo sapiens	158-163
26643788-7	2015	Moreover, curcumin diet reduced benzo[a]pyrene-induced activation of NF-kappaB and MAPK signaling and Cox-2 transcription in lung tissues of mice.	Curcumin	10-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-78
26507910-0	2015	Anti-inflammatory effect of curcumin on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse.	Curcumin	28-36	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	81-90
26507910-3	2015	In the present study, the effect of curcumin on allergic responses in ovalbumin (OVA)-induced allergic rhinitis mouse was investigated.	Curcumin	36-44	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	70-79
26507910-5	2015	Also, we found that curcumin improved rhinitis symptoms, inhibited the histopathological changes of nasal mucosa, and decreased the serum levels of histamine, OVA-specific IgE and TNF-alpha in OVA-induced allergic rhinitis mice.	Curcumin	20-28	tumor necrosis factor	Mus musculus	180-189
26507910-6	2015	In addition, curcumin suppressed the production of inflammatory cytokines, such as TNF-alpha, IL-1beta, IL-6 and IL-8.	Curcumin	13-21	tumor necrosis factor	Mus musculus	83-92
26507910-6	2015	In addition, curcumin suppressed the production of inflammatory cytokines, such as TNF-alpha, IL-1beta, IL-6 and IL-8.	Curcumin	13-21	interleukin 1 beta	Mus musculus	94-102
26507910-6	2015	In addition, curcumin suppressed the production of inflammatory cytokines, such as TNF-alpha, IL-1beta, IL-6 and IL-8.	Curcumin	13-21	interleukin 6	Mus musculus	104-108
25716014-8	2015	mRNA and protein expression of caspase-3 and caspase-9 and proapoptotic genes was increased in cells treated with a combination of curcumin and carboplatin, whereas expression of the antiapoptotic Bcl-2 gene was suppressed.	Curcumin	131-139	BCL2 apoptosis regulator	Homo sapiens	197-202
25716014-11	2015	Our study demonstrated that the synergistic antitumor activity of curcumin combined with carboplatin is mediated by multiple mechanisms involving suppression of NF-kappaB via inhibition of the Akt/IKKalpha pathway and enhanced ERK1/2 activity.	Curcumin	66-74	nuclear factor kappa B subunit 1	Homo sapiens	161-170
25716014-11	2015	Our study demonstrated that the synergistic antitumor activity of curcumin combined with carboplatin is mediated by multiple mechanisms involving suppression of NF-kappaB via inhibition of the Akt/IKKalpha pathway and enhanced ERK1/2 activity.	Curcumin	66-74	AKT serine/threonine kinase 1	Homo sapiens	193-196
25716014-11	2015	Our study demonstrated that the synergistic antitumor activity of curcumin combined with carboplatin is mediated by multiple mechanisms involving suppression of NF-kappaB via inhibition of the Akt/IKKalpha pathway and enhanced ERK1/2 activity.	Curcumin	66-74	mitogen-activated protein kinase 3	Homo sapiens	227-233
26460892-0	2015	Curcumin induces p53-independent necrosis in H1299 cells via a mitochondria-associated pathway.	Curcumin	0-8	tumor protein p53	Homo sapiens	17-20
26218141-10	2015	In wild-type and in Il10 mice, curcumin increased bacterial richness, prevented age-related decrease in alpha diversity, increased the relative abundance of Lactobacillales, and decreased Coriobacterales order.	Curcumin	31-39	interleukin 10	Mus musculus	20-24
26218141-11	2015	Taxonomic profile of AOM/Il10 mice receiving curcumin was more similar to those of wild-type mice than those fed control diet.	Curcumin	45-53	interleukin 10	Mus musculus	25-29
26218141-12	2015	CONCLUSIONS: In AOM/Il10 model, curcumin reduced or eliminated colonic tumor burden with limited effects on mucosal immune responses.	Curcumin	32-40	interleukin 10	Mus musculus	20-24
26302188-5	2015	However, curcumin reversed the morphological changes, abrogated the increased expression of mesenchymal markers, and rescued E-cadherin expression in CoCl2-treated hepatocytes, suggesting the inhibition of hepatocyte EMT in vitro.	Curcumin	9-17	cadherin 1	Homo sapiens	125-135
26250869-3	2015	Here, we sought to investigate the role and mechanism of curcumin on the inhibition of mature IL-1beta production via the regulation of NLRP3 inflammasome.	Curcumin	57-65	interleukin 1 beta	Mus musculus	94-102
26250869-4	2015	METHODS AND RESULTS: Curcumin dramatically inhibited the production of mature IL-1beta in LPS-primed macrophages triggered by multiple NLRP3 inflammasome activators, and also reduced the level of cleaved caspase-1 as measured by western blot and ELISA.	Curcumin	21-29	interleukin 1 beta	Mus musculus	78-86
26351877-0	2015	Curcumin inhibits cell proliferation and induces apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of PI3K/Akt signaling pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	164-167
26351877-2	2015	The aim of the present study was to investigate whether the anticancer effect of curcumin inhibited cell proliferation and induced apoptosis of human NSCLC through the upregulation of microRNA-192-5p (miR-192-5p) and suppression of the PI3K/Akt signaling pathway.	Curcumin	81-89	AKT serine/threonine kinase 1	Homo sapiens	241-244
26351877-3	2015	In the present study, treatment with curcumin inhibited cell proliferation, induced cell apoptosis and increased the caspase-3 activity of A549 cells.	Curcumin	37-45	caspase 3	Homo sapiens	117-126
26351877-7	2015	Curcumin treatment effectively increased the relative miR-192-5p expression and suppressed the PI3K/Akt signaling pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	100-103
26351877-10	2015	Collectively, our findings suggested that curcumin inhibited cell proliferation and induced apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of the PI3K/Akt signaling pathway.	Curcumin	42-50	AKT serine/threonine kinase 1	Homo sapiens	211-214
26250869-7	2015	Furthermore, administration of curcumin significantly reduced peritoneal IL-1beta and HMGB-1 concentration induced by LPS and improved the survival of mice suffering from lethal endotoxic shock.	Curcumin	31-39	interleukin 1 beta	Mus musculus	73-81
26032092-0	2015	Curcumin inhibits growth of prostate carcinoma via miR-208-mediated CDKN1A activation.	Curcumin	0-8	microRNA 208a	Homo sapiens	51-58
26032092-0	2015	Curcumin inhibits growth of prostate carcinoma via miR-208-mediated CDKN1A activation.	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	68-74
26032092-6	2015	Further analyses showed that Curcumin dose-dependently increased a cell cycle suppressor CDKN1A at protein levels, but not mRNA levels, in PC cells, suggesting that Curcumin may regulate the translation of CDKN1A, as well as a possible involvement of miRNA intervention.	Curcumin	29-37	cyclin dependent kinase inhibitor 1A	Homo sapiens	89-95
26032092-6	2015	Further analyses showed that Curcumin dose-dependently increased a cell cycle suppressor CDKN1A at protein levels, but not mRNA levels, in PC cells, suggesting that Curcumin may regulate the translation of CDKN1A, as well as a possible involvement of miRNA intervention.	Curcumin	29-37	cyclin dependent kinase inhibitor 1A	Homo sapiens	206-212
26032092-6	2015	Further analyses showed that Curcumin dose-dependently increased a cell cycle suppressor CDKN1A at protein levels, but not mRNA levels, in PC cells, suggesting that Curcumin may regulate the translation of CDKN1A, as well as a possible involvement of miRNA intervention.	Curcumin	165-173	cyclin dependent kinase inhibitor 1A	Homo sapiens	89-95
26032092-6	2015	Further analyses showed that Curcumin dose-dependently increased a cell cycle suppressor CDKN1A at protein levels, but not mRNA levels, in PC cells, suggesting that Curcumin may regulate the translation of CDKN1A, as well as a possible involvement of miRNA intervention.	Curcumin	165-173	cyclin dependent kinase inhibitor 1A	Homo sapiens	206-212
26032092-7	2015	From all CDKN1A-3"-UTR-binding miRNAs, we found that miR-208 was specifically inhibited in PC cells dose-dependently by Curcumin.	Curcumin	120-128	cyclin dependent kinase inhibitor 1A	Homo sapiens	9-15
26032092-7	2015	From all CDKN1A-3"-UTR-binding miRNAs, we found that miR-208 was specifically inhibited in PC cells dose-dependently by Curcumin.	Curcumin	120-128	microRNA 208a	Homo sapiens	53-60
26032092-10	2015	Together, these data suggest that Curcumin inhibits growth of PC via miR-208-mediated CDKN1A activation.	Curcumin	34-42	microRNA 208a	Homo sapiens	69-76
26032092-10	2015	Together, these data suggest that Curcumin inhibits growth of PC via miR-208-mediated CDKN1A activation.	Curcumin	34-42	cyclin dependent kinase inhibitor 1A	Homo sapiens	86-92
26460892-1	2015	Curcumin has been shown to have various therapeutic and/or adjuvant therapeutic effects on human cancers, as it inhibits cancer cell proliferation and induces apoptosis through p53-dependent molecular pathways.	Curcumin	0-8	tumor protein p53	Homo sapiens	177-180
26460892-2	2015	However, numerous cancer cell types bear a mutant p53 gene, and whether curcumin has any therapeutic effects on p53-deficient/mutant cancer cells has remained elusive.	Curcumin	72-80	tumor protein p53	Homo sapiens	112-115
26460892-5	2015	Western blot analysis of the cytosolic and mitochondrial fractions of H1299 cells as well as a fluorometric caspase assay indicated that curcumin-induced necrosis was mitochondria- and caspase-dependent, and resulted in cytochrome c release.	Curcumin	137-145	cytochrome c, somatic	Homo sapiens	220-232
26460892-7	2015	In conclusion, the present study suggested that curcumin-induced necrotic cell death was mediated via a p53-independent molecular pathway, which was associated with Bax and Bak translocation, caspase activation and cytochrome c release.	Curcumin	48-56	tumor protein p53	Homo sapiens	104-107
26460892-7	2015	In conclusion, the present study suggested that curcumin-induced necrotic cell death was mediated via a p53-independent molecular pathway, which was associated with Bax and Bak translocation, caspase activation and cytochrome c release.	Curcumin	48-56	BCL2 associated X, apoptosis regulator	Homo sapiens	165-168
26460892-7	2015	In conclusion, the present study suggested that curcumin-induced necrotic cell death was mediated via a p53-independent molecular pathway, which was associated with Bax and Bak translocation, caspase activation and cytochrome c release.	Curcumin	48-56	cytochrome c, somatic	Homo sapiens	215-227
25331984-0	2015	Inhibition of beta-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo.	Curcumin	44-52	signal transducer and activator of transcription 3	Mus musculus	31-36
26300394-6	2015	Treatment of SCI rats with curcumin increased osteocalcin mRNA expression and reduced mRNA levels of tartrate-resistant acid phosphatase and mRNA ratio of receptor activator of NF-kappaB ligand/osteoprotegerin in distal femurs.	Curcumin	27-35	bone gamma-carboxyglutamate protein	Rattus norvegicus	46-57
26464579-7	2015	Curcumin mediates several processes like restoration of CD4(+)/CD8(+) T cell populations, reversal of type-2 cytokine bias, reduction of Treg cell population and suppression of T cell apoptosis; all these help to resurrect tumor immune surveillance that leads to tumor regression.	Curcumin	0-8	CD4 molecule	Homo sapiens	56-59
26457069-8	2015	An insight into the molecular mechanism has unraveled the mode of action via which curcumin could affect the key regulators in CSC, importantly; (1) the signaling pathways, including Wnt/beta-catenin, Sonic Hedgehog, Notch and PI3K/Akt/mTOR, (2) microRNA and (3) the epithelial-mesenchymal transition at multiple levels.	Curcumin	83-91	AKT serine/threonine kinase 1	Homo sapiens	232-235
26457069-8	2015	An insight into the molecular mechanism has unraveled the mode of action via which curcumin could affect the key regulators in CSC, importantly; (1) the signaling pathways, including Wnt/beta-catenin, Sonic Hedgehog, Notch and PI3K/Akt/mTOR, (2) microRNA and (3) the epithelial-mesenchymal transition at multiple levels.	Curcumin	83-91	mechanistic target of rapamycin kinase	Homo sapiens	236-240
26468449-6	2015	We will also outline the various mechanisms of EGFR inhibition that are induced by naturally occurring chemopreventative agents such as ginseng, green tea, and curcumin.	Curcumin	160-168	epidermal growth factor receptor	Homo sapiens	47-51
26338965-9	2015	Interestingly, treatment of active breast stromal fibroblasts with curcumin increased the level of the p16(INK4A) coding CDKN2A mRNA and miR-146b-5p and suppressed IL-6, which confirms the repressive effect of these two tumor suppressor molecules on IL-6, and shows the possible "normalization" of cancer-related active fibroblasts.	Curcumin	67-75	cyclin dependent kinase inhibitor 2A	Homo sapiens	103-106
26338965-9	2015	Interestingly, treatment of active breast stromal fibroblasts with curcumin increased the level of the p16(INK4A) coding CDKN2A mRNA and miR-146b-5p and suppressed IL-6, which confirms the repressive effect of these two tumor suppressor molecules on IL-6, and shows the possible "normalization" of cancer-related active fibroblasts.	Curcumin	67-75	cyclin dependent kinase inhibitor 2A	Homo sapiens	107-112
26338965-9	2015	Interestingly, treatment of active breast stromal fibroblasts with curcumin increased the level of the p16(INK4A) coding CDKN2A mRNA and miR-146b-5p and suppressed IL-6, which confirms the repressive effect of these two tumor suppressor molecules on IL-6, and shows the possible "normalization" of cancer-related active fibroblasts.	Curcumin	67-75	cyclin dependent kinase inhibitor 2A	Homo sapiens	121-127
26338965-9	2015	Interestingly, treatment of active breast stromal fibroblasts with curcumin increased the level of the p16(INK4A) coding CDKN2A mRNA and miR-146b-5p and suppressed IL-6, which confirms the repressive effect of these two tumor suppressor molecules on IL-6, and shows the possible "normalization" of cancer-related active fibroblasts.	Curcumin	67-75	interleukin 6	Homo sapiens	164-168
26338965-9	2015	Interestingly, treatment of active breast stromal fibroblasts with curcumin increased the level of the p16(INK4A) coding CDKN2A mRNA and miR-146b-5p and suppressed IL-6, which confirms the repressive effect of these two tumor suppressor molecules on IL-6, and shows the possible "normalization" of cancer-related active fibroblasts.	Curcumin	67-75	interleukin 6	Homo sapiens	250-254
29124225-9	2015	These curcumin derivatives exhibited high inhibitory effects on Abeta aggregation and induced the formation of lower molecular size Abeta species that have weaker cell toxicity.	Curcumin	6-14	amyloid beta precursor protein	Homo sapiens	64-69
26386817-1	2015	We synthesized a library of curcumin mimics with diverse alkylsulfonyl and substituted benzenesulfonyl modifications through a simple addition reaction of important intermediate, 1-(3-Amino-phenyl)-3-(4-hydroxy-3-methoxy-phenyl)-propenone (10), with various sulfonyl chloride reactants and then tested their vasodilatation effect on depolarization (50 mM K(+))- and endothelin-1 (ET-1)-induced basilar artery contraction.	Curcumin	28-36	endothelin 1	Homo sapiens	366-378
26386817-1	2015	We synthesized a library of curcumin mimics with diverse alkylsulfonyl and substituted benzenesulfonyl modifications through a simple addition reaction of important intermediate, 1-(3-Amino-phenyl)-3-(4-hydroxy-3-methoxy-phenyl)-propenone (10), with various sulfonyl chloride reactants and then tested their vasodilatation effect on depolarization (50 mM K(+))- and endothelin-1 (ET-1)-induced basilar artery contraction.	Curcumin	28-36	endothelin 1	Homo sapiens	380-384
25331984-5	2015	A newly synthesized curcumin analog has inhibitory potential against beta-catenin and STAT3.	Curcumin	20-28	signal transducer and activator of transcription 3	Mus musculus	86-91
25331984-11	2015	CONCLUSION: beta-Catenin and STAT3 can be pharmacologically inhibited in vivo with a curcumin analog, which effectively inhibits beta-catenin and STAT3.	Curcumin	85-93	signal transducer and activator of transcription 3	Mus musculus	29-34
25331984-11	2015	CONCLUSION: beta-Catenin and STAT3 can be pharmacologically inhibited in vivo with a curcumin analog, which effectively inhibits beta-catenin and STAT3.	Curcumin	85-93	signal transducer and activator of transcription 3	Mus musculus	146-151
26310655-5	2015	Curcumin-treatment of A549 cells induced a loss of the mitochondrial membrane potential and increased cytosolic cytochrome c.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	112-124
25877858-6	2015	Topical delivery of curcumin nanoparticle in the eye showed enhanced retention of curcumin in the cornea, and significant improvement in prevention of corneal neovascularization over free curcumin as graded clinically and by histopathology; suppression in the expression of VEGF, inflammatory cytokines, and MMP was evidenced in the treated cornea.	Curcumin	20-28	vascular endothelial growth factor A	Homo sapiens	274-278
26167809-8	2015	Furthermore, caveolin-1, the inhibitor of eNOS, was decreased by curcumin.	Curcumin	65-73	caveolin 1	Rattus norvegicus	13-23
25877858-7	2015	Curcumin inhibited NFkappaB in LPS-induced corneal cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	19-27
25877858-11	2015	Curcumin NPs suppress the expression of VEGF, inflammatory cytokines, and MMP.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	40-44
25877858-12	2015	Curcumin NPs prevent corneal neovascularization by suppressing the NFkappaB pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	67-75
25890434-0	2015	Curcumin-mediated regulation of Notch1/hairy and enhancer of split-1/survivin: molecular targeting in cholangiocarcinoma.	Curcumin	0-8	notch receptor 1	Homo sapiens	32-68
25890434-4	2015	Based on recent findings, we hypothesized that curcumin, a polyphenolic phytochemical, suppresses CCA growth in vitro via inhibition of Notch1 signaling.	Curcumin	47-55	notch receptor 1	Homo sapiens	136-142
25890434-10	2015	Statistically significant reductions in cell viability were observed with curcumin treatment at concentrations of 7.5, 10, and 15 muM by approximately 10%, 48%, and 56% for CCLP-1 and 13%, 25%, and 50% for SG-231, respectively.	Curcumin	74-82	PPFIA binding protein 2	Homo sapiens	173-179
25890434-14	2015	CONCLUSIONS: Curcumin effectively induces CCA (CCLP-1 and SG-231) growth suppression and apoptosis at relatively low treatment concentrations when compared with the previous research.	Curcumin	13-21	PPFIA binding protein 2	Homo sapiens	47-64
26600714-0	2015	Curcumin attenuates chronic ethanol-induced liver injury by inhibition of oxidative stress via mitogen-activated protein kinase/nuclear factor E2-related factor 2 pathway in mice.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-162
26278015-0	2015	Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels.	Curcumin	0-8	cathelicidin antimicrobial peptide	Rattus norvegicus	112-116
26278015-4	2015	The present study aimed to examine the effects of combination of endurance training (eTR) and curcumin treatment on the expression of AMPK, SIRT1, PGC-1alpha, and OXPHOS subunits, mitochondrial DNA copy number, and CS activity in rat skeletal muscle.	Curcumin	94-102	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	134-138
26278015-4	2015	The present study aimed to examine the effects of combination of endurance training (eTR) and curcumin treatment on the expression of AMPK, SIRT1, PGC-1alpha, and OXPHOS subunits, mitochondrial DNA copy number, and CS activity in rat skeletal muscle.	Curcumin	94-102	PPARG coactivator 1 alpha	Rattus norvegicus	147-157
26278015-5	2015	Furthermore, the present study also examined the effect of exercise and curcumin treatment on the levels of cAMP and downstream targets of PKA including phosphorylated CREB and LKB-1.	Curcumin	72-80	cathelicidin antimicrobial peptide	Rattus norvegicus	108-112
26278015-11	2015	Furthermore, curcumin treatment as well as exercise also increased levels of cAMP and downstream target of PKA including phosphorylation CREB and LKB-1 which are involved in the regulation of mitochondrial biogenesis.	Curcumin	13-21	cathelicidin antimicrobial peptide	Rattus norvegicus	77-81
26278015-12	2015	CONCLUSION: Taken together, these results suggest that the combination of curcumin treatment and eTR has the potential to accelerate mitochondrial biogenesis in skeletal muscle by increasing cAMP levels.	Curcumin	74-82	cathelicidin antimicrobial peptide	Rattus norvegicus	191-195
26166196-0	2015	Curcumin induces apoptosis in pancreatic cancer cells through the induction of forkhead box O1 and inhibition of the PI3K/Akt pathway.	Curcumin	0-8	forkhead box O1	Homo sapiens	79-94
26166196-0	2015	Curcumin induces apoptosis in pancreatic cancer cells through the induction of forkhead box O1 and inhibition of the PI3K/Akt pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	122-125
26166196-3	2015	The aims of the present study were to investigate the effects and molecular mechanisms of curcumin on the induction of anti-proliferation, cell cycle arrest and apoptosis, by FOXO1, in pancreatic cancer cells.	Curcumin	90-98	forkhead box O1	Homo sapiens	175-180
26166196-8	2015	The findings revealed that curcumin significantly decreased cell proliferation, which was associated with increased expression of the p21/CIP1 and p27/KIP1 cyclin-dependent kinase inhibitors, and inhibited expression of cyclin D1.	Curcumin	27-35	cyclin dependent kinase inhibitor 1A	Homo sapiens	138-142
26166196-9	2015	In addition, curcumin induced apoptosis by decreasing the Bcl-2/Bax protein ratio and increasing caspase-9/3 activation in the pancreatic cancer cells.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	58-63
26166196-9	2015	In addition, curcumin induced apoptosis by decreasing the Bcl-2/Bax protein ratio and increasing caspase-9/3 activation in the pancreatic cancer cells.	Curcumin	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	64-67
26166196-10	2015	Using siRNA against FOXO1, and Akt inhibitor and activator, the present study confirmed that curcumin induced the expression of FOXO1 by inhibition of phosphoinositide 3-kinase/Akt signaling, leading to cell cycle arrest and apoptosis.	Curcumin	93-101	forkhead box O1	Homo sapiens	20-25
26166196-10	2015	Using siRNA against FOXO1, and Akt inhibitor and activator, the present study confirmed that curcumin induced the expression of FOXO1 by inhibition of phosphoinositide 3-kinase/Akt signaling, leading to cell cycle arrest and apoptosis.	Curcumin	93-101	AKT serine/threonine kinase 1	Homo sapiens	31-34
26166196-10	2015	Using siRNA against FOXO1, and Akt inhibitor and activator, the present study confirmed that curcumin induced the expression of FOXO1 by inhibition of phosphoinositide 3-kinase/Akt signaling, leading to cell cycle arrest and apoptosis.	Curcumin	93-101	forkhead box O1	Homo sapiens	128-133
26166196-10	2015	Using siRNA against FOXO1, and Akt inhibitor and activator, the present study confirmed that curcumin induced the expression of FOXO1 by inhibition of phosphoinositide 3-kinase/Akt signaling, leading to cell cycle arrest and apoptosis.	Curcumin	93-101	AKT serine/threonine kinase 1	Homo sapiens	177-180
26600714-10	2015	CONCLUSION: Our data suggested that curcumin protected the liver from chronic-ethanol induced injury through attenuating oxidative stress, at least partially, through ERK/p38/Nrf2-mediated anti-oxidant signaling pathways.	Curcumin	36-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	175-179
26664018-0	2015	Curcumin half analog modulates interleukin-6 and tumor necrosis factor-alpha in inflammatory bowel disease.	Curcumin	0-8	interleukin 6	Rattus norvegicus	31-76
27013798-0	2015	Modulation of Hepatic Cytochrome P450 Enzymes by Curcumin and its Pharmacokinetic Consequences in Sprague-dawley Rats.	Curcumin	49-57	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	22-37
26600714-9	2015	In addition, curcumin increased Nrf2 activation and anti-oxidative genes expressions such as NQO1, HO-1, and SOD through inducing extracellular signal-regulated kinase (ERK) and p38 phosphorylation.	Curcumin	13-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	32-36
26600714-9	2015	In addition, curcumin increased Nrf2 activation and anti-oxidative genes expressions such as NQO1, HO-1, and SOD through inducing extracellular signal-regulated kinase (ERK) and p38 phosphorylation.	Curcumin	13-21	mitogen-activated protein kinase 1	Mus musculus	130-167
26600714-9	2015	In addition, curcumin increased Nrf2 activation and anti-oxidative genes expressions such as NQO1, HO-1, and SOD through inducing extracellular signal-regulated kinase (ERK) and p38 phosphorylation.	Curcumin	13-21	mitogen-activated protein kinase 1	Mus musculus	169-172
26600714-10	2015	CONCLUSION: Our data suggested that curcumin protected the liver from chronic-ethanol induced injury through attenuating oxidative stress, at least partially, through ERK/p38/Nrf2-mediated anti-oxidant signaling pathways.	Curcumin	36-44	mitogen-activated protein kinase 1	Mus musculus	167-170
26677679-13	2015	CONCLUSIONS: Curcumin not only could inhibit TGF-beta2 induced proliferation of lung fibroblasts, but also could inhibit the synthesis of collagens.	Curcumin	13-21	transforming growth factor, beta 2	Mus musculus	45-54
26677679-0	2015	[Effect of Curcumin on TGF-beta2 Regulated PPAR-gamma/PDGF-beta Signaling Pathway in Lung Fibroblasts of Mice].	Curcumin	11-19	transforming growth factor, beta 2	Mus musculus	23-32
25891177-0	2015	A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response.	Curcumin	2-10	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
26677679-1	2015	OBJECTIVE: To explore the effect of curcumin on TGF-beta2 regulated peroxisome proliferater activated receptor y (PPAR-gamma)/platelet derived growth factor beta (PDGF-beta) signaling pathway in lung fibroblasts of mice.	Curcumin	36-44	transforming growth factor, beta 2	Mus musculus	48-57
26677679-7	2015	Compared with the TGF-beta2 group, mRNA expressions of PPAR-gamma obviously increased in the TGF-beta2 (10 ng/mL) plus curcumin 25 mumol/L group and the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group, higher than that in the TGF-beta2 (10 ng/mL) plus curcumin 5 [mumol/L group (P &lt; 0.05).	Curcumin	179-187	transforming growth factor, beta 2	Mus musculus	93-102
26677679-7	2015	Compared with the TGF-beta2 group, mRNA expressions of PPAR-gamma obviously increased in the TGF-beta2 (10 ng/mL) plus curcumin 25 mumol/L group and the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group, higher than that in the TGF-beta2 (10 ng/mL) plus curcumin 5 [mumol/L group (P &lt; 0.05).	Curcumin	179-187	transforming growth factor, beta 2	Mus musculus	93-102
26677679-7	2015	Compared with the TGF-beta2 group, mRNA expressions of PPAR-gamma obviously increased in the TGF-beta2 (10 ng/mL) plus curcumin 25 mumol/L group and the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group, higher than that in the TGF-beta2 (10 ng/mL) plus curcumin 5 [mumol/L group (P &lt; 0.05).	Curcumin	179-187	transforming growth factor, beta 2	Mus musculus	93-102
26677679-7	2015	Compared with the TGF-beta2 group, mRNA expressions of PPAR-gamma obviously increased in the TGF-beta2 (10 ng/mL) plus curcumin 25 mumol/L group and the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group, higher than that in the TGF-beta2 (10 ng/mL) plus curcumin 5 [mumol/L group (P &lt; 0.05).	Curcumin	179-187	transforming growth factor, beta 2	Mus musculus	93-102
26677679-7	2015	Compared with the TGF-beta2 group, mRNA expressions of PPAR-gamma obviously increased in the TGF-beta2 (10 ng/mL) plus curcumin 25 mumol/L group and the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group, higher than that in the TGF-beta2 (10 ng/mL) plus curcumin 5 [mumol/L group (P &lt; 0.05).	Curcumin	179-187	transforming growth factor, beta 2	Mus musculus	93-102
26677679-7	2015	Compared with the TGF-beta2 group, mRNA expressions of PPAR-gamma obviously increased in the TGF-beta2 (10 ng/mL) plus curcumin 25 mumol/L group and the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group, higher than that in the TGF-beta2 (10 ng/mL) plus curcumin 5 [mumol/L group (P &lt; 0.05).	Curcumin	179-187	transforming growth factor, beta 2	Mus musculus	93-102
26305550-0	2015	Curcumin combined with FAPalphac vaccine elicits effective antitumor response by targeting indolamine-2,3-dioxygenase and inhibiting EMT induced by TNF-alpha in melanoma.	Curcumin	0-8	IL2 inducible T cell kinase	Mus musculus	133-136
26305550-0	2015	Curcumin combined with FAPalphac vaccine elicits effective antitumor response by targeting indolamine-2,3-dioxygenase and inhibiting EMT induced by TNF-alpha in melanoma.	Curcumin	0-8	tumor necrosis factor	Mus musculus	148-157
26393568-10	2015	Quercetin, curcumin and bisdemethoxycurcumin contributed to both GLUT5- and GLUT2-mediated fructose uptake inhibition, but the contribution to GLUT5 inhibition was higher than the contribution to GLUT2 inhibition.	Curcumin	11-19	solute carrier family 2 member 5	Homo sapiens	65-70
26305550-5	2015	We found that curcumin can inhibit IDO expression and TNF-alpha-induced EMT.	Curcumin	14-22	tumor necrosis factor	Mus musculus	54-63
26305550-5	2015	We found that curcumin can inhibit IDO expression and TNF-alpha-induced EMT.	Curcumin	14-22	IL2 inducible T cell kinase	Mus musculus	72-75
26382065-7	2015	In this study, we show that curcumin at low concentrations (1.25-3.12 muM) has a strong anti-proliferative effect on TNF-alpha-induced psoriasis-like inflammation when applied in combination with light-emitting-diode devices.	Curcumin	28-36	tumor necrosis factor	Homo sapiens	117-126
26361331-6	2015	Peritoneal cells prepared from mice injected in vivo with the liposomes containing curcumin apparently decreased interleukin-6-producing activities.	Curcumin	83-91	interleukin 6	Mus musculus	113-126
25891177-5	2015	Thus, we have developed new curcumin derivatives and tested their Nrf2 induction.	Curcumin	28-36	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
25891177-6	2015	RESULTS: Based on curcumin, we synthesized curcumin analogs with five carbon linkages and established a structure-activity relationship for Nrf2 induction.	Curcumin	18-26	NFE2 like bZIP transcription factor 2	Homo sapiens	140-144
25891177-6	2015	RESULTS: Based on curcumin, we synthesized curcumin analogs with five carbon linkages and established a structure-activity relationship for Nrf2 induction.	Curcumin	43-51	NFE2 like bZIP transcription factor 2	Homo sapiens	140-144
25891177-11	2015	INNOVATION: The curcumin derivative, BHBA, is a potent inducer of Nrf2.	Curcumin	16-24	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
25891177-14	2015	CONCLUSION: Taken together, our results demonstrate that BHBA, a curcumin analog with improved Nrf2-activating and chemopreventive activities both in vitro and in vivo, could be developed into a chemoprotective pharmacological agent.	Curcumin	65-73	NFE2 like bZIP transcription factor 2	Homo sapiens	95-99
26116834-4	2015	Curcumin treatment also decreased AKT phosphorylation and VEGF expression and release.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	58-62
26102194-0	2015	Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells.	Curcumin	0-8	GLI family zinc finger 2	Homo sapiens	111-116
26116710-9	2015	The increases in iNOS and cybb mRNA were not attenuated by the AT1 receptor antagonist losartan but abolished by the AP-1 blocker curcumin.	Curcumin	130-138	nitric oxide synthase 2	Rattus norvegicus	17-21
26219195-0	2015	Effects of curcumin on crevicular levels of IL-1beta and CCL28 in experimental gingivitis.	Curcumin	11-19	interleukin 1 beta	Homo sapiens	44-52
26219195-0	2015	Effects of curcumin on crevicular levels of IL-1beta and CCL28 in experimental gingivitis.	Curcumin	11-19	C-C motif chemokine ligand 28	Homo sapiens	57-62
26219195-2	2015	The aim of this study was to compare interleukin-1beta (IL-1beta) and chemokine (C-C motif) ligand 28 (CCL28) levels following a topical application of curcumin (CRM), chlorhexidine (CHX) and chlorhexidine-metronidazole (CHX-MTZ) in an experimental gingivitis human model.	Curcumin	152-160	interleukin 1 beta	Homo sapiens	56-64
26219195-2	2015	The aim of this study was to compare interleukin-1beta (IL-1beta) and chemokine (C-C motif) ligand 28 (CCL28) levels following a topical application of curcumin (CRM), chlorhexidine (CHX) and chlorhexidine-metronidazole (CHX-MTZ) in an experimental gingivitis human model.	Curcumin	152-160	C-C motif chemokine ligand 28	Homo sapiens	103-108
26219195-2	2015	The aim of this study was to compare interleukin-1beta (IL-1beta) and chemokine (C-C motif) ligand 28 (CCL28) levels following a topical application of curcumin (CRM), chlorhexidine (CHX) and chlorhexidine-metronidazole (CHX-MTZ) in an experimental gingivitis human model.	Curcumin	162-165	C-C motif chemokine ligand 28	Homo sapiens	103-108
26219195-10	2015	CONCLUSIONS: The anti-inflammatory potential of topical curcumin was similar to CHX-MTZ but superior to CHX in affecting IL-1beta and CCL28 levels.	Curcumin	56-64	interleukin 1 beta	Homo sapiens	121-129
26219195-10	2015	CONCLUSIONS: The anti-inflammatory potential of topical curcumin was similar to CHX-MTZ but superior to CHX in affecting IL-1beta and CCL28 levels.	Curcumin	56-64	C-C motif chemokine ligand 28	Homo sapiens	134-139
26380101-0	2015	Significantly reduced lymphadenopathy, salivary gland infiltrates and proteinuria in MRL-lpr/lpr mice treated with ultrasoluble curcumin/turmeric: increased survival with curcumin treatment.	Curcumin	128-136	Fas (TNF receptor superfamily member 6)	Mus musculus	89-92
26380101-0	2015	Significantly reduced lymphadenopathy, salivary gland infiltrates and proteinuria in MRL-lpr/lpr mice treated with ultrasoluble curcumin/turmeric: increased survival with curcumin treatment.	Curcumin	128-136	Fas (TNF receptor superfamily member 6)	Mus musculus	93-96
25711190-0	2015	Curcumin Mediates a Protective Effect Via TLR-4/NF-kappaB Signaling Pathway in Rat Model of Severe Acute Pancreatitis.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	42-47
25711190-5	2015	The levels of serum cytokines IL-10 and TNF-alpha were also significantly reduced after curcumin treatment, as evident from ELISA analysis.	Curcumin	88-96	tumor necrosis factor	Rattus norvegicus	40-49
25711190-6	2015	RT-PCR analysis showed down-regulation of TLR4 and NF-kappaB expressions as a function of curcumin treatment.	Curcumin	90-98	toll-like receptor 4	Rattus norvegicus	42-46
25711190-7	2015	Our results demonstrate the protective effect of curcumin in a rat model of SAP via the involvement of TLR-4/NF-kappaB signaling pathway.	Curcumin	49-57	toll-like receptor 4	Rattus norvegicus	103-108
26102194-3	2015	In this study, results showed that curcumin dramatically increased the expression of ATP-binding cassette transporter 1 (ABCA1), promoted cholesterol efflux from THP-1 macrophage-derived foam cells, and reduced cellular cholesterol levels.	Curcumin	35-43	GLI family zinc finger 2	Homo sapiens	162-167
26102194-6	2015	Thus, curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through activating AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells.	Curcumin	6-14	GLI family zinc finger 2	Homo sapiens	128-133
25998196-16	2015	Moreover, nuclear factor-kappaB activation, concentrations of the inflammatory cytokines tumour necrosis factor-alpha and interleukin-1beta and oxidative stress were increased in the skeletal muscle from DM mice and inhibited in DM+Curcumin mice.	Curcumin	232-240	interleukin 1 beta	Mus musculus	122-139
28454943-1	2015	Soy protein isolate (SPI) can act as effective nanocarriers for water-insoluble curcumin, however, the maximal capacity of this protein to load curcumin and molecular mechanism for the formation of the nanocomplexes are still little known.	Curcumin	80-88	chromogranin A	Homo sapiens	21-24
28454943-1	2015	Soy protein isolate (SPI) can act as effective nanocarriers for water-insoluble curcumin, however, the maximal capacity of this protein to load curcumin and molecular mechanism for the formation of the nanocomplexes are still little known.	Curcumin	144-152	chromogranin A	Homo sapiens	21-24
28454943-4	2015	The load amount (LA) of curcumin in the non-treated nanocomplexes reached 103.9mug/mg SPI.	Curcumin	24-32	chromogranin A	Homo sapiens	86-89
28454943-6	2015	The complexation with curcumin significantly increased the particle size and zeta-potential of both non- and ultrasonic-treated SPIs, but led to a considerable reduction in surface hydrophobicity, with the greater changes observed for ultrasonic-treated SPI.	Curcumin	22-30	chromogranin A	Homo sapiens	128-131
28454943-7	2015	The nanocomplexation with SPIs remarkably improved the storage stability of curcumin, with much better improvement observed for the ultrasonic-treated SPI.	Curcumin	76-84	chromogranin A	Homo sapiens	26-29
28454943-8	2015	Both the number and nature of hydrophobic sites are important for the nanoparticles in SPI to exhibit high capacity to load curcumin molecules.	Curcumin	124-132	chromogranin A	Homo sapiens	87-90
28454943-9	2015	This study confirmed that SPI exhibited a high capacity to load water-insoluble curcumin, and an ultrasonic pretreatment could further improve its encapsulation efficiency and stability of curcumin.	Curcumin	80-88	chromogranin A	Homo sapiens	26-29
28454943-9	2015	This study confirmed that SPI exhibited a high capacity to load water-insoluble curcumin, and an ultrasonic pretreatment could further improve its encapsulation efficiency and stability of curcumin.	Curcumin	189-197	chromogranin A	Homo sapiens	26-29
28454977-0	2015	Curcumin encapsulated in the complex of lysozyme/carboxymethylcellulose and implications for the antioxidant activity of curcumin.	Curcumin	0-8	lysozyme	Homo sapiens	40-48
28454977-0	2015	Curcumin encapsulated in the complex of lysozyme/carboxymethylcellulose and implications for the antioxidant activity of curcumin.	Curcumin	121-129	lysozyme	Homo sapiens	40-48
28454977-1	2015	A facile approach was investigated to encapsulate and protect curcumin (Cur) by self-assembly of lysozyme (Ly) and carboxymethylcellulose (CMC) of different degrees of substitution (DSs).	Curcumin	62-70	lysozyme	Homo sapiens	97-105
28454977-1	2015	A facile approach was investigated to encapsulate and protect curcumin (Cur) by self-assembly of lysozyme (Ly) and carboxymethylcellulose (CMC) of different degrees of substitution (DSs).	Curcumin	62-70	lysozyme	Homo sapiens	107-109
26036622-0	2015	Curcumin Inhibits Invasiveness and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Through Reducing Matrix Metalloproteinase 2, 9 and Modulating p53-E-Cadherin Pathway.	Curcumin	0-8	tumor protein p53	Homo sapiens	163-166
26036622-0	2015	Curcumin Inhibits Invasiveness and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Through Reducing Matrix Metalloproteinase 2, 9 and Modulating p53-E-Cadherin Pathway.	Curcumin	0-8	cadherin 1	Homo sapiens	167-177
26036622-5	2015	RESULTS: Our data showed that curcumin treatment not only decreased the expression of MMP-2 and MMP-9 to inhibit invasiveness in oral cancer but also modulated the expression of EMT markers, such as Snail, Twist, and E-cadherin, and induced p53 expression that is crucial to EMT repression.	Curcumin	30-38	cadherin 1	Homo sapiens	217-227
26036622-5	2015	RESULTS: Our data showed that curcumin treatment not only decreased the expression of MMP-2 and MMP-9 to inhibit invasiveness in oral cancer but also modulated the expression of EMT markers, such as Snail, Twist, and E-cadherin, and induced p53 expression that is crucial to EMT repression.	Curcumin	30-38	tumor protein p53	Homo sapiens	241-244
26036700-0	2015	Curcumin Targeted, Polymalic Acid-Based MRI Contrast Agent for the Detection of Abeta Plaques in Alzheimer"s Disease.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	80-85
26472972-9	2015	Curcumin and citral generated ROS and activated p53 and poly (ADP-ribose) polymerase-1 mediated apoptotic pathways.	Curcumin	0-8	tumor protein p53	Homo sapiens	48-51
26472972-9	2015	Curcumin and citral generated ROS and activated p53 and poly (ADP-ribose) polymerase-1 mediated apoptotic pathways.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	56-86
25937435-0	2015	Curcumin effectively inhibits oncogenic NF-kappaB signaling and restrains stemness features in liver cancer.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	40-49
25937435-3	2015	METHODS: We evaluated the CSCs-depleting potential of NF-kappaB inhibition in liver cancer achieved by the IKK inhibitor curcumin, RNAi and specific peptide SN50.	Curcumin	121-129	nuclear factor kappa B subunit 1	Homo sapiens	54-63
25937435-7	2015	In sensitive lines, curcumin-mediated induction of cell death was directly related to the extent of NF-kappaB inhibition.	Curcumin	20-28	nuclear factor kappa B subunit 1	Homo sapiens	100-109
25937435-11	2015	Mechanistically, an important component of the CSC-depleting activity of curcumin could be attributed to a NF-kappaB-mediated HDAC inhibition.	Curcumin	73-81	nuclear factor kappa B subunit 1	Homo sapiens	107-116
25937435-13	2015	Further, integration of a predictive signature of curcumin sensitivity with human HCC database indicated that HCCs with poor prognosis and progenitor features are most likely to benefit from NF-kappaB inhibition.	Curcumin	50-58	holocytochrome c synthase	Homo sapiens	110-114
25937435-13	2015	Further, integration of a predictive signature of curcumin sensitivity with human HCC database indicated that HCCs with poor prognosis and progenitor features are most likely to benefit from NF-kappaB inhibition.	Curcumin	50-58	nuclear factor kappa B subunit 1	Homo sapiens	191-200
26366279-0	2015	Effect of curcumin on the interaction between androgen receptor and Wnt/beta-catenin in LNCaP xenografts.	Curcumin	10-18	androgen receptor	Homo sapiens	46-63
26036700-3	2015	Curcumin (CUR), a common Indian spice effectively binds to Abeta plaques which is a hallmark of AD.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	59-64
26366279-2	2015	Our previous study showed that curcumin inhibits androgen receptor (AR) through modulation of Wnt/beta-catenin signaling in LNCaP cells.	Curcumin	31-39	androgen receptor	Homo sapiens	49-66
26366279-2	2015	Our previous study showed that curcumin inhibits androgen receptor (AR) through modulation of Wnt/beta-catenin signaling in LNCaP cells.	Curcumin	31-39	androgen receptor	Homo sapiens	68-70
26047311-5	2015	Most interesting was the observation that the glial protective effects related to HO-1 induction were microglial specific as shown in glial cultures from LysM(Cre) Hmox( / ) mice where curcumin lost its protective effect.	Curcumin	185-193	lysozyme 2	Mus musculus	154-158
26366279-10	2015	Curcumin significantly decreased AR expression at both the mRNA and protein level.	Curcumin	0-8	androgen receptor	Homo sapiens	33-35
26366279-13	2015	CONCLUSIONS: This study revealed that curcumin initially interferes with prostate cancer growth by inhibiting AR activity and possibly by reducing PSA expression.	Curcumin	38-46	androgen receptor	Homo sapiens	110-112
26047311-5	2015	Most interesting was the observation that the glial protective effects related to HO-1 induction were microglial specific as shown in glial cultures from LysM(Cre) Hmox( / ) mice where curcumin lost its protective effect.	Curcumin	185-193	heme oxygenase 1	Mus musculus	164-168
26047311-6	2015	Under LPS conditions, curcumin reduced the microglial proinflammatory markers iNOS and tumor necrosis factor, but increased the anti-inflammatory cytokine IL4.	Curcumin	22-30	nitric oxide synthase 2	Rattus norvegicus	78-82
26622667-8	2015	Combined treatment with ERK inhibitor U0126 and curcumin resulted in a synergistic reduction in MMP-2/-9 expression; the invasive capabilities of HEC-1B cells were also inhibited.	Curcumin	48-56	NDC80 kinetochore complex component	Homo sapiens	146-151
26622667-6	2015	Moreover, curcumin treatment significantly decreased the levels of the phosphorylated form of extracellular signal-regulated kinase (ERK) 1/2.	Curcumin	10-18	mitogen-activated protein kinase 3	Homo sapiens	94-141
26622667-9	2015	In conclusion, curcumin inhibits tumor cell migration and invasion by reducing the expression and activity of MMP-2/9 via the suppression of the ERK signaling pathway, suggesting that curcumin is a potential therapeutic agent for EC.	Curcumin	15-23	mitogen-activated protein kinase 1	Homo sapiens	145-148
26622667-9	2015	In conclusion, curcumin inhibits tumor cell migration and invasion by reducing the expression and activity of MMP-2/9 via the suppression of the ERK signaling pathway, suggesting that curcumin is a potential therapeutic agent for EC.	Curcumin	184-192	mitogen-activated protein kinase 1	Homo sapiens	145-148
26420919-0	2015	Curcumin binds in silico to anti-cancer drug target enzyme MMP-3 (human stromelysin-1) with affinity comparable to two known inhibitors of the enzyme.	Curcumin	0-8	matrix metallopeptidase 3	Homo sapiens	59-64
26420919-0	2015	Curcumin binds in silico to anti-cancer drug target enzyme MMP-3 (human stromelysin-1) with affinity comparable to two known inhibitors of the enzyme.	Curcumin	0-8	matrix metallopeptidase 3	Homo sapiens	72-85
26420919-1	2015	In silico interaction of curcumin with the enzyme MMP-3 (human stromelysin-1) was studied by molecular docking using AutoDock 4.2 as the docking software application.	Curcumin	25-33	matrix metallopeptidase 3	Homo sapiens	50-55
26420919-1	2015	In silico interaction of curcumin with the enzyme MMP-3 (human stromelysin-1) was studied by molecular docking using AutoDock 4.2 as the docking software application.	Curcumin	25-33	matrix metallopeptidase 3	Homo sapiens	63-76
26420919-3	2015	Interactions of curcumin with MMP-3 were compared to those of two known inhibitors of the enzyme, PBSA and MPPT.	Curcumin	16-24	matrix metallopeptidase 3	Homo sapiens	30-35
26420919-8	2015	Thus, curcumin can be considered as a good lead compound in the development of new inhibitors of MMP-3 which is a potential target of anticancer drugs.	Curcumin	6-14	matrix metallopeptidase 3	Homo sapiens	97-102
26305906-0	2015	Curcumin Improves the Tumoricidal Effect of Mitomycin C by Suppressing ABCG2 Expression in Stem Cell-Like Breast Cancer Cells.	Curcumin	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	71-76
26832707-5	2015	RESULTS: Compared with the blank control group, the high-dose curcumin plus conventional treatment group, low-dose curcumin plus conventional treatment group, high-dose curcumin group, and PQ poisoning group had significantly increased serum levels of TGF-beta1, TNF-alpha, and IL-6 (P&lt;0.05) , and the three cytokines in each group reached peak levels on day 14 after exposure.	Curcumin	62-70	transforming growth factor, beta 1	Rattus norvegicus	252-261
26832707-5	2015	RESULTS: Compared with the blank control group, the high-dose curcumin plus conventional treatment group, low-dose curcumin plus conventional treatment group, high-dose curcumin group, and PQ poisoning group had significantly increased serum levels of TGF-beta1, TNF-alpha, and IL-6 (P&lt;0.05) , and the three cytokines in each group reached peak levels on day 14 after exposure.	Curcumin	115-123	transforming growth factor, beta 1	Rattus norvegicus	252-261
26832707-5	2015	RESULTS: Compared with the blank control group, the high-dose curcumin plus conventional treatment group, low-dose curcumin plus conventional treatment group, high-dose curcumin group, and PQ poisoning group had significantly increased serum levels of TGF-beta1, TNF-alpha, and IL-6 (P&lt;0.05) , and the three cytokines in each group reached peak levels on day 14 after exposure.	Curcumin	115-123	transforming growth factor, beta 1	Rattus norvegicus	252-261
26832707-6	2015	Compared with the PQ poisoning group, the high-dose curcumin group had significantly reduced serum levels of TGF-beta1, TNF-alpha, and IL-6 (P&lt;0.05).	Curcumin	52-60	transforming growth factor, beta 1	Rattus norvegicus	109-118
26832707-6	2015	Compared with the PQ poisoning group, the high-dose curcumin group had significantly reduced serum levels of TGF-beta1, TNF-alpha, and IL-6 (P&lt;0.05).	Curcumin	52-60	tumor necrosis factor	Rattus norvegicus	120-129
26832707-6	2015	Compared with the PQ poisoning group, the high-dose curcumin group had significantly reduced serum levels of TGF-beta1, TNF-alpha, and IL-6 (P&lt;0.05).	Curcumin	52-60	interleukin 6	Rattus norvegicus	135-139
26345159-2	2015	Curcumin (CM), a yellow hydrophobic polyphenol derived from the herb turmeric, has various pharmacological activities against many chronic diseases and acts by inhibiting cell proliferation and metastasis and downregulating various factors, including nuclear factor kappa B, interleukin-1beta and TNF-alpha.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	275-292
26345159-2	2015	Curcumin (CM), a yellow hydrophobic polyphenol derived from the herb turmeric, has various pharmacological activities against many chronic diseases and acts by inhibiting cell proliferation and metastasis and downregulating various factors, including nuclear factor kappa B, interleukin-1beta and TNF-alpha.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	297-306
26165427-7	2015	It has been demonstrated that natural compounds derived from plants, vegetables, fungi and micronutrients (such as curcumin, sulforaphane, resveratrol and vitamin D among others) can activate Nrf2 and, thus, promote antioxidant pathways to mitigate oxidative stress and hyperglycemic damage.	Curcumin	115-123	NFE2 like bZIP transcription factor 2	Homo sapiens	192-196
26305906-7	2015	Curcumin sensitized BCSCs through a reduction in the expression of ATP-binding cassette (ABC) transporters ABCG2 and ABCC1.	Curcumin	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	107-112
26305906-7	2015	Curcumin sensitized BCSCs through a reduction in the expression of ATP-binding cassette (ABC) transporters ABCG2 and ABCC1.	Curcumin	0-8	ATP binding cassette subfamily C member 1	Homo sapiens	117-122
26305906-9	2015	Curcumin sensitized breast cancer cells to chemotherapeutic drugs by reducing the BCSC population mainly through a reduction in the expression of ABCG2.	Curcumin	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	146-151
26478933-0	2015	Retraction notice to "Dual ACE-inhibition and angiotensin II AT1 receptor antagonism with curcumin attenuate maladaptive cardiac repair and improve ventricular systolic function after myocardial infarction in rat heart" [Eur.J.Pharmacol.January(2015)22-30].	Curcumin	90-98	angiotensin I converting enzyme	Rattus norvegicus	27-30
26244872-5	2015	Curcumin, a nutrient with anti-Jak3 activity and histone deacetylase inhibitors (HDACi) also trigger increased expression of pri-miR-22 and miR-22.	Curcumin	0-8	microRNA 22	Homo sapiens	129-135
26244872-5	2015	Curcumin, a nutrient with anti-Jak3 activity and histone deacetylase inhibitors (HDACi) also trigger increased expression of pri-miR-22 and miR-22.	Curcumin	0-8	microRNA 22	Homo sapiens	140-146
26331164-0	2015	Retraction notice to "Dual ACE-inhibition and angiotensin IIAT1 receptor antagonism with curcumin attenuate maladaptive cardiac repair and improve ventricular systolic function after myocardial infarction in rat heart" [Eur.J.Pharmacol.January(2015)22-30].	Curcumin	89-97	angiotensin I converting enzyme	Rattus norvegicus	27-30
26827544-0	2015	[The effects of curcumin on PTEN/PI3K/Akt pathway in Ec109 cells].	Curcumin	16-24	AKT serine/threonine kinase 1	Homo sapiens	38-41
26827544-1	2015	OBJECTIVE: To investigate the inhibition effect of curcumin on the proliferation of the human esophageal carcinoma cell line Ec109 and its impact on PEN/PI3K/Akt signaling pathway.	Curcumin	51-59	AKT serine/threonine kinase 1	Homo sapiens	158-161
26827544-4	2015	The protein levels of PTEN, Akt, GSK3P and Caspase 3 of curcumin-treated Ec109 cells were detected by Western blot.	Curcumin	56-64	caspase 3	Homo sapiens	43-52
26827544-8	2015	On the other hand, curcumin could promote the expression of PTEN, GSK3beta and Caspase 3 yet reduce the expression of Akt.	Curcumin	19-27	caspase 3	Homo sapiens	79-88
26827544-8	2015	On the other hand, curcumin could promote the expression of PTEN, GSK3beta and Caspase 3 yet reduce the expression of Akt.	Curcumin	19-27	AKT serine/threonine kinase 1	Homo sapiens	118-121
26827544-9	2015	CONCLUSION: Curcumin could obviously up-regulate the expression of PTEN, GSK3beta and Caspase 3, surpress PI3K/Akt signaling pathway and hence inhibit the proliferation of Ec109 cells.	Curcumin	12-20	AKT serine/threonine kinase 1	Homo sapiens	111-114
26048786-3	2015	Compared with curcumin and parent NSAID (salicylic acid and salsalate), topical application of A11 and B13 onto mouse ear edema, prior to TPA treatment markedly suppressed the expression of IL-1beta, IL-6 and TNF-alpha, respectively.	Curcumin	14-22	annexin A11, opposite strand	Mus musculus	95-98
26254223-8	2015	Taken together, these findings establish curcumin as a modulator of VEGF and VEGF-VEGFR2 signaling pathway, with potential implication for improving the quality of life of cancer patients.	Curcumin	41-49	vascular endothelial growth factor A	Homo sapiens	68-72
26254223-8	2015	Taken together, these findings establish curcumin as a modulator of VEGF and VEGF-VEGFR2 signaling pathway, with potential implication for improving the quality of life of cancer patients.	Curcumin	41-49	vascular endothelial growth factor A	Homo sapiens	77-81
25994015-6	2015	Confocal fluorescence microscopy analysis of Granta cells following incubation with alpha-CD20 scFv apoA-I ND formulated with the intrinsically fluorescent hydrophobic polyphenol, curcumin, revealed alpha-CD20 scFv apoA-I localizes to the cell surface, while curcumin off-loads and gains entry to the cell.	Curcumin	180-188	keratin 20	Homo sapiens	90-94
25994015-6	2015	Confocal fluorescence microscopy analysis of Granta cells following incubation with alpha-CD20 scFv apoA-I ND formulated with the intrinsically fluorescent hydrophobic polyphenol, curcumin, revealed alpha-CD20 scFv apoA-I localizes to the cell surface, while curcumin off-loads and gains entry to the cell.	Curcumin	180-188	immunglobulin heavy chain variable region	Homo sapiens	95-99
25994015-6	2015	Confocal fluorescence microscopy analysis of Granta cells following incubation with alpha-CD20 scFv apoA-I ND formulated with the intrinsically fluorescent hydrophobic polyphenol, curcumin, revealed alpha-CD20 scFv apoA-I localizes to the cell surface, while curcumin off-loads and gains entry to the cell.	Curcumin	180-188	apolipoprotein A1	Homo sapiens	100-106
26116776-4	2015	At the molecular level, curcumin and ABT-737 synergistically induced mitochondrial permeability transition pore (mPTP) opening in melanoma cells, the latter was evidenced by mitochondrial membrane potential (MPP) reduction and mitochondrial complexation between cyclophilin-D (CyPD) and adenine nucleotide translocator 1 (ANT-1).	Curcumin	24-32	peptidylprolyl isomerase F	Homo sapiens	262-275
26116776-4	2015	At the molecular level, curcumin and ABT-737 synergistically induced mitochondrial permeability transition pore (mPTP) opening in melanoma cells, the latter was evidenced by mitochondrial membrane potential (MPP) reduction and mitochondrial complexation between cyclophilin-D (CyPD) and adenine nucleotide translocator 1 (ANT-1).	Curcumin	24-32	peptidylprolyl isomerase F	Homo sapiens	277-281
25994015-6	2015	Confocal fluorescence microscopy analysis of Granta cells following incubation with alpha-CD20 scFv apoA-I ND formulated with the intrinsically fluorescent hydrophobic polyphenol, curcumin, revealed alpha-CD20 scFv apoA-I localizes to the cell surface, while curcumin off-loads and gains entry to the cell.	Curcumin	180-188	keratin 20	Homo sapiens	205-209
25795285-9	2015	Curcumin increased interleukin-6 concentrations at 0-h (31 %; +-29 %) and 48-h (32 %; +-29 %) relative to baseline, but decreased IL-6 at 24-h relative to post-exercise (-20 %; +-18 %).	Curcumin	0-8	interleukin 6	Homo sapiens	19-32
25994015-6	2015	Confocal fluorescence microscopy analysis of Granta cells following incubation with alpha-CD20 scFv apoA-I ND formulated with the intrinsically fluorescent hydrophobic polyphenol, curcumin, revealed alpha-CD20 scFv apoA-I localizes to the cell surface, while curcumin off-loads and gains entry to the cell.	Curcumin	180-188	immunglobulin heavy chain variable region	Homo sapiens	210-214
25994015-6	2015	Confocal fluorescence microscopy analysis of Granta cells following incubation with alpha-CD20 scFv apoA-I ND formulated with the intrinsically fluorescent hydrophobic polyphenol, curcumin, revealed alpha-CD20 scFv apoA-I localizes to the cell surface, while curcumin off-loads and gains entry to the cell.	Curcumin	180-188	apolipoprotein A1	Homo sapiens	215-221
25994015-6	2015	Confocal fluorescence microscopy analysis of Granta cells following incubation with alpha-CD20 scFv apoA-I ND formulated with the intrinsically fluorescent hydrophobic polyphenol, curcumin, revealed alpha-CD20 scFv apoA-I localizes to the cell surface, while curcumin off-loads and gains entry to the cell.	Curcumin	259-267	keratin 20	Homo sapiens	90-94
25994015-6	2015	Confocal fluorescence microscopy analysis of Granta cells following incubation with alpha-CD20 scFv apoA-I ND formulated with the intrinsically fluorescent hydrophobic polyphenol, curcumin, revealed alpha-CD20 scFv apoA-I localizes to the cell surface, while curcumin off-loads and gains entry to the cell.	Curcumin	259-267	immunglobulin heavy chain variable region	Homo sapiens	95-99
25994015-6	2015	Confocal fluorescence microscopy analysis of Granta cells following incubation with alpha-CD20 scFv apoA-I ND formulated with the intrinsically fluorescent hydrophobic polyphenol, curcumin, revealed alpha-CD20 scFv apoA-I localizes to the cell surface, while curcumin off-loads and gains entry to the cell.	Curcumin	259-267	apolipoprotein A1	Homo sapiens	100-106
25994015-7	2015	Compared to control incubations, viability of cultured NHL cells was decreased upon incubation with alpha-CD20 scFv apoA-I ND harboring curcumin.	Curcumin	136-144	keratin 20	Homo sapiens	106-110
25994015-7	2015	Compared to control incubations, viability of cultured NHL cells was decreased upon incubation with alpha-CD20 scFv apoA-I ND harboring curcumin.	Curcumin	136-144	immunglobulin heavy chain variable region	Homo sapiens	111-115
25994015-7	2015	Compared to control incubations, viability of cultured NHL cells was decreased upon incubation with alpha-CD20 scFv apoA-I ND harboring curcumin.	Curcumin	136-144	apolipoprotein A1	Homo sapiens	116-122
25994015-8	2015	Thus, formulation of curcumin ND with alpha-CD20 scFv apoA-I as the scaffold component confers cell targeting and enhanced bioactive agent delivery, providing a strategy to minimize toxicity associated with chemotherapeutic agents.	Curcumin	21-29	keratin 20	Homo sapiens	44-48
25994015-8	2015	Thus, formulation of curcumin ND with alpha-CD20 scFv apoA-I as the scaffold component confers cell targeting and enhanced bioactive agent delivery, providing a strategy to minimize toxicity associated with chemotherapeutic agents.	Curcumin	21-29	immunglobulin heavy chain variable region	Homo sapiens	49-53
25994015-8	2015	Thus, formulation of curcumin ND with alpha-CD20 scFv apoA-I as the scaffold component confers cell targeting and enhanced bioactive agent delivery, providing a strategy to minimize toxicity associated with chemotherapeutic agents.	Curcumin	21-29	apolipoprotein A1	Homo sapiens	54-60
25795285-9	2015	Curcumin increased interleukin-6 concentrations at 0-h (31 %; +-29 %) and 48-h (32 %; +-29 %) relative to baseline, but decreased IL-6 at 24-h relative to post-exercise (-20 %; +-18 %).	Curcumin	0-8	interleukin 6	Homo sapiens	130-134
25979368-0	2015	Curcumin potentiates the anti-leukemia effects of imatinib by downregulation of the AKT/mTOR pathway and BCR/ABL gene expression in Ph+ acute lymphoblastic leukemia.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	84-87
25979368-0	2015	Curcumin potentiates the anti-leukemia effects of imatinib by downregulation of the AKT/mTOR pathway and BCR/ABL gene expression in Ph+ acute lymphoblastic leukemia.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	88-92
25979368-6	2015	Here, we reported that curcumin induced apoptosis by inhibition of AKT/mTOR and ABL/STAT5 signaling, down-regulation of BCR/ABL expression, and induction of the BCL2/BAX imbalance.	Curcumin	23-31	AKT serine/threonine kinase 1	Homo sapiens	67-70
25979368-6	2015	Here, we reported that curcumin induced apoptosis by inhibition of AKT/mTOR and ABL/STAT5 signaling, down-regulation of BCR/ABL expression, and induction of the BCL2/BAX imbalance.	Curcumin	23-31	mechanistic target of rapamycin kinase	Homo sapiens	71-75
25979368-6	2015	Here, we reported that curcumin induced apoptosis by inhibition of AKT/mTOR and ABL/STAT5 signaling, down-regulation of BCR/ABL expression, and induction of the BCL2/BAX imbalance.	Curcumin	23-31	BCL2 apoptosis regulator	Homo sapiens	161-165
25979368-6	2015	Here, we reported that curcumin induced apoptosis by inhibition of AKT/mTOR and ABL/STAT5 signaling, down-regulation of BCR/ABL expression, and induction of the BCL2/BAX imbalance.	Curcumin	23-31	BCL2 associated X, apoptosis regulator	Homo sapiens	166-169
25979368-7	2015	Curcumin exerted synergetic anti-leukemia effects with imatinib by inhibition of the imatinib-mediated overactivation of AKT/mTOR signaling and down-regulation of BCR/ABL gene expression.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	121-124
25979368-7	2015	Curcumin exerted synergetic anti-leukemia effects with imatinib by inhibition of the imatinib-mediated overactivation of AKT/mTOR signaling and down-regulation of BCR/ABL gene expression.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	125-129
26464676-0	2015	Effect of curcumin on Bcl-2 and Bax expression in nude mice prostate cancer.	Curcumin	10-18	B cell leukemia/lymphoma 2	Mus musculus	22-27
26464676-3	2015	This study aimed to explore the curcumin induced prostate cancer cell apoptosis and apoptosis related proteins Bcl-2 and Bax expression.	Curcumin	32-40	B cell leukemia/lymphoma 2	Mus musculus	111-116
26464676-13	2015	Curcumin could inhibit PC-3 growth, decrease tumor volume, reduce tumor weight, and induce cell apoptosis under the skin of nude mice by up-regulating Bax and down-regulating Bcl-2.	Curcumin	0-8	B cell leukemia/lymphoma 2	Mus musculus	175-180
26305715-10	2015	Gain- or loss-of-function analyses revealed Nrf2 and FXR mediated the effect of curcumin on lipid deposition in hepatocytes, and curcumin modulated the expression of FXR mediated by Nrf2.	Curcumin	129-137	NFE2 like bZIP transcription factor 2	Homo sapiens	182-186
26305715-0	2015	Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	73-77
26305715-8	2015	Additionally, curcumin induced the expression of Nrf2 and FXR in liver, strongly implying close relationship between inhibitory effect of curcumin on hepatic steatosis and the above two genes.	Curcumin	14-22	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
26305715-8	2015	Additionally, curcumin induced the expression of Nrf2 and FXR in liver, strongly implying close relationship between inhibitory effect of curcumin on hepatic steatosis and the above two genes.	Curcumin	138-146	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
26305715-11	2015	Collectively, we drew a conclusion that curcumin attenuated ALD by modulating lipid deposition in hepatocytes via a Nrf2/FXR activation-dependent mechanism.	Curcumin	40-48	NFE2 like bZIP transcription factor 2	Homo sapiens	116-120
26305715-10	2015	Gain- or loss-of-function analyses revealed Nrf2 and FXR mediated the effect of curcumin on lipid deposition in hepatocytes, and curcumin modulated the expression of FXR mediated by Nrf2.	Curcumin	80-88	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
25944087-0	2015	Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13.	Curcumin	0-8	interleukin 13	Rattus norvegicus	69-74
26073546-2	2015	Water solubility of curcumin in curcumin-Eudragit  E PO solid dispersion (Cur@EPO) was greatly increased.	Curcumin	20-28	erythropoietin	Homo sapiens	74-81
26073546-2	2015	Water solubility of curcumin in curcumin-Eudragit  E PO solid dispersion (Cur@EPO) was greatly increased.	Curcumin	32-40	erythropoietin	Homo sapiens	74-81
26073546-5	2015	Cur@EPO also provided protection function for curcumin as verified by the pH challenge and UV irradiation test.	Curcumin	46-54	erythropoietin	Homo sapiens	0-7
26073546-7	2015	Additionally, in vitro transdermal test was conducted to assess the potential of Cur@EPO as a vehicle to deliver curcumin through this alternative administration route.	Curcumin	113-121	erythropoietin	Homo sapiens	81-88
26232254-9	2015	With curcumin in TK6 cells, induction of caspase-3/7 activity coincided with MN induction, whereas for L5178Y cells, MN induction occurred in the absence of increased caspase activity.	Curcumin	5-13	caspase 3	Homo sapiens	41-50
26066335-10	2015	Furthermore, curcumin decreases inflammatory cytokines interleukin 1beta and tumor necrosis factor alpha level, increases plasma brain-derived neurotrophic factor levels, and decreases salivary cortisol concentrations compared with placebo group.	Curcumin	13-21	interleukin 1 beta	Homo sapiens	55-104
25944087-3	2015	Curcumin increased interleukin-4 (IL-4) and interleukin-13 (IL-13) mRNA expression and protein secretion.	Curcumin	0-8	interleukin 13	Rattus norvegicus	44-58
25944087-3	2015	Curcumin increased interleukin-4 (IL-4) and interleukin-13 (IL-13) mRNA expression and protein secretion.	Curcumin	0-8	interleukin 13	Rattus norvegicus	60-65
25944087-5	2015	Leflunomide, a STAT6 inhibitor, and IL-4 and/or IL-13 neutralizing antibodies antagonized the induction of MMR, Arg-1 and PPAR-gamma by curcumin in Raw264.7 cells.	Curcumin	136-144	interleukin 13	Mus musculus	48-53
25944087-5	2015	Leflunomide, a STAT6 inhibitor, and IL-4 and/or IL-13 neutralizing antibodies antagonized the induction of MMR, Arg-1 and PPAR-gamma by curcumin in Raw264.7 cells.	Curcumin	136-144	ATPase, class II, type 9B	Mus musculus	107-110
25944087-8	2015	Curcumin also reduced the inflammatory cell infiltration and myocardial mRNA levels of interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS).	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	87-104
25944087-8	2015	Curcumin also reduced the inflammatory cell infiltration and myocardial mRNA levels of interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS).	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	106-114
25944087-8	2015	Curcumin also reduced the inflammatory cell infiltration and myocardial mRNA levels of interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS).	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	120-151
25944087-8	2015	Curcumin also reduced the inflammatory cell infiltration and myocardial mRNA levels of interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS).	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	153-157
25944087-9	2015	Meanwhile, the myocardial mRNA levels of MMR and Arg-1 were markedly up-regulated by curcumin.	Curcumin	85-93	ATPase, class II, type 9B	Mus musculus	41-44
25944087-10	2015	Immunofluorescence assay showed that the number of CD68(+) MMR(+) and CD68(+) Arg-1(+) double positive macrophages in curcumin-treated myocardial tissue was significantly higher than untreated control.	Curcumin	118-126	ATPase, class II, type 9B	Mus musculus	59-62
25944087-11	2015	The number of CD68(+) iNOS(+) double positive macrophages was increased obviously in EAM group, but decreased markedly by curcumin treatment.	Curcumin	122-130	nitric oxide synthase 2	Rattus norvegicus	22-26
25944087-12	2015	CONCLUSIONS: Taken together, these results show that curcumin induces macrophage M2 polarization by secretion of IL-4 and/or IL-13.	Curcumin	53-61	interleukin 13	Rattus norvegicus	125-130
26059056-13	2015	In conclusion, the PKCalpha/Nox-2/ROS/ATF-2/MMP-9 signaling pathway is activated in lung cancer A549 cells, which could be modulated by curcumin to inhibit cell invasiveness.	Curcumin	136-144	protein kinase C alpha	Homo sapiens	19-27
26059056-0	2015	Curcumin inhibits the invasion of lung cancer cells by modulating the PKCalpha/Nox-2/ROS/ATF-2/MMP-9 signaling pathway.	Curcumin	0-8	protein kinase C alpha	Homo sapiens	70-78
26218133-6	2015	Moreover, rpd3 mutants were found to mimic the curcumin-induced suppression of the DNA damage response.	Curcumin	47-55	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	10-14
26059056-12	2015	Finally, we also showed that curcumin dose-dependently reduced the expression of PKCalpha, P47phox, Nox-2 and phosphorylated ATF-2, as well as intracellular ROS generation, suggesting the inhibitory effect of curcumin on the activation of the PKCalpha/Nox-2/ROS/ATF-2 pathway.	Curcumin	29-37	protein kinase C alpha	Homo sapiens	81-89
26059056-12	2015	Finally, we also showed that curcumin dose-dependently reduced the expression of PKCalpha, P47phox, Nox-2 and phosphorylated ATF-2, as well as intracellular ROS generation, suggesting the inhibitory effect of curcumin on the activation of the PKCalpha/Nox-2/ROS/ATF-2 pathway.	Curcumin	29-37	protein kinase C alpha	Homo sapiens	243-251
26059056-12	2015	Finally, we also showed that curcumin dose-dependently reduced the expression of PKCalpha, P47phox, Nox-2 and phosphorylated ATF-2, as well as intracellular ROS generation, suggesting the inhibitory effect of curcumin on the activation of the PKCalpha/Nox-2/ROS/ATF-2 pathway.	Curcumin	209-217	protein kinase C alpha	Homo sapiens	243-251
25981383-7	2015	Additionally, curcumin decreased RARbeta promoter methylation in lung cancer A549 and H460 cells.	Curcumin	14-22	retinoic acid receptor beta	Homo sapiens	33-40
25981383-8	2015	Mechanistic study demonstrated that curcumin was able to downregulate the mRNA levels of DNMT3b.	Curcumin	36-44	DNA methyltransferase 3B	Mus musculus	89-95
25981383-11	2015	As the results from in vitro, RARbeta mRNA were increased and DNMT3b mRNA were decreased by curcumin treatment compared with the mice in control group.	Curcumin	92-100	DNA methyltransferase 3B	Mus musculus	62-68
25744732-9	2015	Diclofenac and curcumin overcome these carcinogenic effects by downregulating telomerase activity, diminishing the expression of TERT, CDK4, CDK2, cyclin D1, and cyclin E.	Curcumin	15-23	cyclin-dependent kinase 4	Rattus norvegicus	135-139
25744732-9	2015	Diclofenac and curcumin overcome these carcinogenic effects by downregulating telomerase activity, diminishing the expression of TERT, CDK4, CDK2, cyclin D1, and cyclin E.	Curcumin	15-23	cyclin D1	Rattus norvegicus	147-156
25744732-9	2015	Diclofenac and curcumin overcome these carcinogenic effects by downregulating telomerase activity, diminishing the expression of TERT, CDK4, CDK2, cyclin D1, and cyclin E.	Curcumin	15-23	cyclin E1	Rattus norvegicus	162-170
26223780-5	2015	RESULTS: Among a number of commonly used herbal constituents, we found that the application of rhein, emodin, curcumin and resveratrol significantly suppressed the mRNA and protein levels of several fibrotic mediators namely alpha-smooth muscle actin, type I collagen and fibronectin in LTC-14 cells against transforming growth factor-beta stimulation.	Curcumin	110-118	fibronectin 1	Homo sapiens	272-283
26046466-8	2015	Mechanistically, we defined that curcumin markedly down-regulated Skp2 expression and subsequently up-regulated p57 expression.	Curcumin	33-41	cyclin dependent kinase inhibitor 1C	Homo sapiens	112-115
25708189-8	2015	Therefore, it is important to look for compounds that cause a selective activation of Nrf2 particularly natural substances such as curcumin, sulforaphane, or extracts from the broccoli leaves without side effects.	Curcumin	131-139	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90
26129848-9	2015	L49H37 was found to be more potent at a lower concentration than curcumin in the induction of apoptosis, as evidenced by cleaved poly (ADP-ribose) polymerase (PARP).	Curcumin	65-73	poly(ADP-ribose) polymerase 1	Homo sapiens	159-163
26314434-0	2015	[Inhibitory Effect of Curcumin on Proliferation of CD34(+) Acute Myeloid Leukemia Cells and Its Mechanism].	Curcumin	22-30	CD34 molecule	Homo sapiens	51-55
26314434-1	2015	OBJECTIVE: To explore the inhibitory effect of curcumin on proliferation of CD34(+) acute myeloid leukemia cells and its mechamism.	Curcumin	47-55	CD34 molecule	Homo sapiens	76-80
26314434-7	2015	Immunofluorescence assay showed that treatment with 40 micromol/L of curcumin for 48h suppressed the nuclear translocation of NF-kappaB p65 in KG1a and Kasumi-1 cells.	Curcumin	69-77	nuclear factor kappa B subunit 1	Homo sapiens	126-135
26314434-8	2015	CONCLUSION: The curcumin suppresses cell growth of KG1a and Kasumi-1 cells, its mechanism may be related to inhibitory effect of curcumin on NF-kappaB p65 nucleus protein.	Curcumin	16-24	nuclear factor kappa B subunit 1	Homo sapiens	141-150
26314434-8	2015	CONCLUSION: The curcumin suppresses cell growth of KG1a and Kasumi-1 cells, its mechanism may be related to inhibitory effect of curcumin on NF-kappaB p65 nucleus protein.	Curcumin	129-137	nuclear factor kappa B subunit 1	Homo sapiens	141-150
25349216-4	2015	The results show that curcumin effectively inhibits hypoxia-induced reactive oxygen species (ROS) upregulation and significantly decreases the mRNA and protein expression levels of hypoxia-inducible factor-1alpha (HIF-1alpha) in K1 cells.	Curcumin	22-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	181-212
26103086-0	2015	Correction to Molecular Basis for Fe(III)-Independent Curcumin Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Activity.	Curcumin	54-62	CF transmembrane conductance regulator	Homo sapiens	79-130
26124332-7	2015	Curcumin also increased phosphorylation of p53 and Histone H2A.X (S140) in the nuclei of NCI-H460 cells.	Curcumin	0-8	tumor protein p53	Homo sapiens	43-46
25349216-4	2015	The results show that curcumin effectively inhibits hypoxia-induced reactive oxygen species (ROS) upregulation and significantly decreases the mRNA and protein expression levels of hypoxia-inducible factor-1alpha (HIF-1alpha) in K1 cells.	Curcumin	22-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	214-224
25349216-6	2015	Furthermore, curcumin enhances E-cadherin expression, inhibits metalloproteinase-9 (MMP-9) enzyme activity, and weakens K1 cells migration under hypoxic conditions.	Curcumin	13-21	cadherin 1	Homo sapiens	31-41
26458588-0	2015	The role of the vascular endothelial growth factor/vascular endothelial growth factor receptors axis mediated angiogenesis in curcumin-loaded nanostructured lipid carriers induced human HepG2 cells apoptosis.	Curcumin	126-134	vascular endothelial growth factor A	Homo sapiens	16-50
26039974-7	2015	In conclusion, treatment with curcumin was able to improve the functional properties of hepatocytes and to inhibit the upregulations of both NF-kappaB and iNOS in the BDL group; however, no beneficial effect was observed on the liver fibrosis developed in this model of cholestasis.	Curcumin	30-38	nitric oxide synthase 2	Rattus norvegicus	155-159
26458588-0	2015	The role of the vascular endothelial growth factor/vascular endothelial growth factor receptors axis mediated angiogenesis in curcumin-loaded nanostructured lipid carriers induced human HepG2 cells apoptosis.	Curcumin	126-134	vascular endothelial growth factor A	Homo sapiens	51-85
25858818-10	2015	Furthermore, we demonstrated that curcumin significantly inhibited the TGFbeta1-induced NOX4 protein expression in HGFs.	Curcumin	34-42	transforming growth factor beta 1	Homo sapiens	71-79
25858818-11	2015	Curcumin potentially qualifies as an agent to control GO by suppressing TGFbeta1-induced NOX4 expression in HGFs.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	72-80
25823828-0	2015	Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase-1.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	120-124
25760477-0	2015	Curcumin triggers apoptosis via upregulation of Bax/Bcl-2 ratio and caspase activation in SW872 human adipocytes.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	48-51
25760477-0	2015	Curcumin triggers apoptosis via upregulation of Bax/Bcl-2 ratio and caspase activation in SW872 human adipocytes.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	52-57
25760477-5	2015	In addition, curcumin treatment resulted in an increased expression of Bax, and a decrease in that of of Bcl-2, with a concomitant upregulation of the Bax/Bcl-2 ratio.	Curcumin	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	71-74
25760477-5	2015	In addition, curcumin treatment resulted in an increased expression of Bax, and a decrease in that of of Bcl-2, with a concomitant upregulation of the Bax/Bcl-2 ratio.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	105-110
25760477-5	2015	In addition, curcumin treatment resulted in an increased expression of Bax, and a decrease in that of of Bcl-2, with a concomitant upregulation of the Bax/Bcl-2 ratio.	Curcumin	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	151-154
25760477-5	2015	In addition, curcumin treatment resulted in an increased expression of Bax, and a decrease in that of of Bcl-2, with a concomitant upregulation of the Bax/Bcl-2 ratio.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	155-160
25760477-6	2015	Curcumin treatment also led to the release of cytochrome c from mitochondria into the cytosol.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	46-58
25760477-7	2015	Similarly, caspase-dependent poly (ADP) ribose polymerase (PARP) cleavage by curcumin was observed in the current study.	Curcumin	77-85	poly(ADP-ribose) polymerase 1	Homo sapiens	59-63
25823828-8	2015	Further analysis revealed that the expression levels of Nrf2 and HO-1 protein were elevated to a greater extent in the curcumin pretreated NRK-52E cells compared with those of the control.	Curcumin	119-127	NFE2 like bZIP transcription factor 2	Rattus norvegicus	56-60
25823828-9	2015	Notably, knockdown of Nrf2 with small interfering RNA prevented the curcumin-induced elevation in expression of HO-1 and the associated anti-fibrotic effects.	Curcumin	68-76	NFE2 like bZIP transcription factor 2	Rattus norvegicus	22-26
25823828-10	2015	In conclusion, the present findings suggested that curcumin may be significant in cellular antioxidant defense, through the activation of Nrf2 and HO-1, thereby protecting the NRK-52E cells from HG-induced EMT.	Curcumin	51-59	NFE2 like bZIP transcription factor 2	Rattus norvegicus	138-142
25791922-0	2015	Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK.	Curcumin	0-8	thioredoxin interacting protein	Homo sapiens	102-107
26273408-10	2015	CONCLUSIONS: Curcumin might exert anti-cancer effects on LSQCC via regulating BER, JAT-STAT, VEGF, and MAPK signaling pathways.	Curcumin	13-21	vascular endothelial growth factor A	Homo sapiens	93-97
26273408-10	2015	CONCLUSIONS: Curcumin might exert anti-cancer effects on LSQCC via regulating BER, JAT-STAT, VEGF, and MAPK signaling pathways.	Curcumin	13-21	mitogen-activated protein kinase 1	Homo sapiens	103-107
25791922-0	2015	Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK.	Curcumin	0-8	NLR family pyrin domain containing 3	Homo sapiens	108-113
25791922-6	2015	As a result, curcumin reduced TXNIP expression and inhibited NLRP3 inflammasome activation by downregulation of NLRP3 and cleaved caspase-1 induction, and thus reduced IL-1beta secretion.	Curcumin	13-21	thioredoxin interacting protein	Homo sapiens	30-35
25791922-6	2015	As a result, curcumin reduced TXNIP expression and inhibited NLRP3 inflammasome activation by downregulation of NLRP3 and cleaved caspase-1 induction, and thus reduced IL-1beta secretion.	Curcumin	13-21	NLR family pyrin domain containing 3	Homo sapiens	61-66
25791922-6	2015	As a result, curcumin reduced TXNIP expression and inhibited NLRP3 inflammasome activation by downregulation of NLRP3 and cleaved caspase-1 induction, and thus reduced IL-1beta secretion.	Curcumin	13-21	NLR family pyrin domain containing 3	Homo sapiens	112-117
25791922-6	2015	As a result, curcumin reduced TXNIP expression and inhibited NLRP3 inflammasome activation by downregulation of NLRP3 and cleaved caspase-1 induction, and thus reduced IL-1beta secretion.	Curcumin	13-21	interleukin 1 beta	Homo sapiens	168-176
25791922-9	2015	Immunohistochemistry showed that curcumin inhibited p-IRE1alpha, p-PERK and NLRP3 expression in hippocampus CA1 region.	Curcumin	33-41	NLR family pyrin domain containing 3	Homo sapiens	76-81
25791922-10	2015	Together, these results showed that curcumin attenuated glutamate neurotoxicity by inhibiting ER stress-associated TXNIP/NLRP3 inflammasome activation via the regulation of AMPK, and thereby protected the hippocampus from ischemic insult.	Curcumin	36-44	thioredoxin interacting protein	Homo sapiens	115-120
25791922-10	2015	Together, these results showed that curcumin attenuated glutamate neurotoxicity by inhibiting ER stress-associated TXNIP/NLRP3 inflammasome activation via the regulation of AMPK, and thereby protected the hippocampus from ischemic insult.	Curcumin	36-44	NLR family pyrin domain containing 3	Homo sapiens	121-126
26261481-0	2015	Curcumin inhibits cell proliferation and promotes apoptosis in human osteoclastoma cell through MMP-9, NF-kappaB and JNK signaling pathways.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	103-112
25866362-0	2015	Pculin02H, a curcumin derivative, inhibits proliferation and clinical drug resistance of HER2-overexpressing cancer cells.	Curcumin	13-21	erb-b2 receptor tyrosine kinase 2	Homo sapiens	89-93
25866362-3	2015	Here, we evaluated whether curcumin derivatives have better efficiency to degrade HER2 than curcumin.	Curcumin	27-35	erb-b2 receptor tyrosine kinase 2	Homo sapiens	82-86
26261481-9	2015	Furthermore, curcumin inhibited the MMP-9 gene expression quantity and NF-kappaB activity, and activated JNK protein expression in GCT cells.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	71-80
26261481-9	2015	Furthermore, curcumin inhibited the MMP-9 gene expression quantity and NF-kappaB activity, and activated JNK protein expression in GCT cells.	Curcumin	13-21	mitogen-activated protein kinase 8	Homo sapiens	105-108
26261481-10	2015	Meanwhile, down-regulation of MMP-9 gene expression quantity and NF-kappaB activity could promote the anti-cancer effect of curcumin on cell viability of GCT cells.	Curcumin	124-132	nuclear factor kappa B subunit 1	Homo sapiens	65-74
26261481-11	2015	Interesting, down-regulation of JNK protein expression could also reversed the anti-cancer effect of curcumin on cell viability of GCT cells.	Curcumin	101-109	mitogen-activated protein kinase 8	Homo sapiens	32-35
26261481-12	2015	Taken together, our results suggest that curcumin inhibits cell proliferation and promotes apoptosis in osteoclastoma cell through suppression of MMP-9 and NF-kappaB, and activation JNK signaling pathways.	Curcumin	41-49	nuclear factor kappa B subunit 1	Homo sapiens	156-165
26114940-0	2015	Curcumin Improves Amyloid beta-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway.	Curcumin	0-8	Eph receptor B1	Rattus norvegicus	91-94
26114940-7	2015	In addition, the beneficial effect of curcumin is accompanied by increased BDNF levels and elevated levels of phosphorylated ERK in the hippocampus.	Curcumin	38-46	Eph receptor B1	Rattus norvegicus	125-128
26114940-8	2015	Furthermore, the cognition enhancement effect of curcumin could be mimicked by the overexpression of BDNF in the hippocampus and blocked by either bilateral hippocampal injections with lentiviruses that express BDNF shRNA or a microinjection of ERK inhibitor.	Curcumin	49-57	Eph receptor B1	Rattus norvegicus	245-248
26114940-9	2015	These findings suggest that chronic curcumin ameliorates AD-related cognitive deficits and that upregulated BDNF-ERK signaling in the hippocampus may underlie the cognitive improvement produced by curcumin.	Curcumin	197-205	Eph receptor B1	Rattus norvegicus	113-116
26111180-8	2015	Combined treatment with curcumin and quercetin resulted in significant inhibition of cell proliferation, accompanied by loss of mitochondrial membrane potential (DeltaPsim), release of cytochrome c and decreased phosphorylation of AKT and ERK.	Curcumin	24-32	cytochrome c, somatic	Homo sapiens	185-197
26111180-8	2015	Combined treatment with curcumin and quercetin resulted in significant inhibition of cell proliferation, accompanied by loss of mitochondrial membrane potential (DeltaPsim), release of cytochrome c and decreased phosphorylation of AKT and ERK.	Curcumin	24-32	AKT serine/threonine kinase 1	Homo sapiens	231-234
26111180-8	2015	Combined treatment with curcumin and quercetin resulted in significant inhibition of cell proliferation, accompanied by loss of mitochondrial membrane potential (DeltaPsim), release of cytochrome c and decreased phosphorylation of AKT and ERK.	Curcumin	24-32	mitogen-activated protein kinase 1	Homo sapiens	239-242
26309628-8	2015	As expected, curcumin inhibited IL-22 induced phosphorylation of STAT3; furthermore, curcumin down regulated cyclin D1 and cyclin E. We can reach a conclusion that curcumin can suppress the proliferation of keratinocytes even with IL-22 treatment.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	65-70
26048285-5	2015	Curcumin prophylaxis significantly attenuated the upregulation of NF-kappaB (p &lt; 0.001), thereby leading to concomitant downregulation of pro-inflammatory cytokine levels ( IL-1, IL-2, IL-18 and TNF-alpha), cell adhesion molecules ( P-selectin and E-selectin) and increased anti-inflammatory cytokine ( IL-10).	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	198-207
26048285-5	2015	Curcumin prophylaxis significantly attenuated the upregulation of NF-kappaB (p &lt; 0.001), thereby leading to concomitant downregulation of pro-inflammatory cytokine levels ( IL-1, IL-2, IL-18 and TNF-alpha), cell adhesion molecules ( P-selectin and E-selectin) and increased anti-inflammatory cytokine ( IL-10).	Curcumin	0-8	selectin P	Rattus norvegicus	236-246
26048285-6	2015	Curcumin stabilized the brain HIF-1alpha levels followed by maintaining VEGF levels along with upregulated Na(+)/K(+)-ATPase and ENaC levels (p &lt; 0.001) under hypoxia.	Curcumin	0-8	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	129-133
26048285-7	2015	Curcumin restored the brain ZO-1, JAMC, claudin 4 and claudin 5 levels (p &lt; 0.001) under hypoxia.	Curcumin	0-8	claudin 4	Rattus norvegicus	40-49
25646742-3	2015	Sensitization to TRAIL has been an area of great research interest, but has met significant challenges because of poor bioavailability, half-life, and solubility of sensitizing compounds such as curcumin.	Curcumin	195-203	TNF superfamily member 10	Homo sapiens	17-22
25646742-4	2015	Soluble, TRAIL-sensitizing compounds were screened on the basis of similarity to the redox-active substructure of curcumin and sensitization to TRAIL-induced apoptosis.	Curcumin	114-122	TNF superfamily member 10	Homo sapiens	9-14
25875220-0	2015	Curcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficacies.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	93-134
25875220-0	2015	Curcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficacies.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	136-140
25875220-8	2015	In addition, curcumin reduced plasma MDA level with enhanced the Nrf2 system specifically regulated protein, NAD(P)H quinone oxidoreductase 1 (NQO-1) together with other anti-oxidative enzymes in patients" blood lymphocytes.	Curcumin	13-21	NFE2 like bZIP transcription factor 2	Homo sapiens	65-69
25875220-8	2015	In addition, curcumin reduced plasma MDA level with enhanced the Nrf2 system specifically regulated protein, NAD(P)H quinone oxidoreductase 1 (NQO-1) together with other anti-oxidative enzymes in patients" blood lymphocytes.	Curcumin	13-21	NAD(P)H quinone dehydrogenase 1	Homo sapiens	109-141
25875220-8	2015	In addition, curcumin reduced plasma MDA level with enhanced the Nrf2 system specifically regulated protein, NAD(P)H quinone oxidoreductase 1 (NQO-1) together with other anti-oxidative enzymes in patients" blood lymphocytes.	Curcumin	13-21	NAD(P)H quinone dehydrogenase 1	Homo sapiens	143-148
25875220-10	2015	Finally, several gut bacterials important for maintaining gut barrier integrity and function were upregulated by curcumin.In conclusion, short-term curcumin intervention ablates DKD progress with activating Nrf2 anti-oxidative system and anti-inflammatory efficacies in patients with T2DM.	Curcumin	113-121	NFE2 like bZIP transcription factor 2	Homo sapiens	207-211
25875220-10	2015	Finally, several gut bacterials important for maintaining gut barrier integrity and function were upregulated by curcumin.In conclusion, short-term curcumin intervention ablates DKD progress with activating Nrf2 anti-oxidative system and anti-inflammatory efficacies in patients with T2DM.	Curcumin	148-156	NFE2 like bZIP transcription factor 2	Homo sapiens	207-211
26261622-12	2015	Application of curcumin can inhibit expression of MMP-9, CD40L, TNF-alpha and CRP to improve the permeability of coronary artery.	Curcumin	15-23	tumor necrosis factor	Rattus norvegicus	64-73
25847862-10	2015	Treatment with curcumin downregulated the expression of Bcl-2, and elevated the phosphorylation level of IP3R in a concentration-dependent manner.	Curcumin	15-23	BCL2 apoptosis regulator	Homo sapiens	56-61
25847862-12	2015	In conclusion, the cytotoxic effects of curcumin on lung cancer cells were induced by calcium overload, which involves Bcl-2 mediated IP3R phosphorylation.	Curcumin	40-48	BCL2 apoptosis regulator	Homo sapiens	119-124
26261481-12	2015	Taken together, our results suggest that curcumin inhibits cell proliferation and promotes apoptosis in osteoclastoma cell through suppression of MMP-9 and NF-kappaB, and activation JNK signaling pathways.	Curcumin	41-49	mitogen-activated protein kinase 8	Homo sapiens	182-185
26261481-0	2015	Curcumin inhibits cell proliferation and promotes apoptosis in human osteoclastoma cell through MMP-9, NF-kappaB and JNK signaling pathways.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	117-120
26261481-7	2015	Firstly, MMP-9, NF-kappaB and JNK inhibitors were added into GCT cells and which was researched the mechanism of curcumin on human GCT cells.	Curcumin	113-121	mitogen-activated protein kinase 8	Homo sapiens	30-33
26261481-8	2015	In this study, the efficacy of curcumin reduced cell viability, induced cellular apoptosis and increased caspase-3 activity of GCT cells.	Curcumin	31-39	caspase 3	Homo sapiens	105-114
25891482-2	2015	It exerts various biological effects, such as anti-inflammatory effects, and we have previously demonstrated that curcumin is a specific inhibitor of DNA polymerase lambda.	Curcumin	114-122	polymerase (DNA directed), lambda	Mus musculus	150-171
25862641-3	2015	Our previous studies have found that a curcumin analog, L48H37 [1-ethyl-3,5-bis(3,4,5-trimethoxybenzylidene)piperidin-4-one], was able to inhibit LPS-induced inflammation, particularly tumor necrosis factor alpha and interleukin 6 production and gene expression in mouse macrophages.	Curcumin	39-47	toll-like receptor 4	Mus musculus	146-149
25891482-7	2015	In in vitro cell culture experiments, the 100-nm curcumin lipid nanoemulsion showed the most prominent inhibitory effect on the production of tumor necrosis factor-alpha (TNF-alpha) induced by lipopolysaccharide (LPS) in RAW264.7 murine macrophages, and on the release of beta-hexosaminidase induced by the calcium ionophore, A23187, in rat basophilic leukemia RBL-2H3 cells.	Curcumin	49-57	tumor necrosis factor	Mus musculus	142-169
25891482-7	2015	In in vitro cell culture experiments, the 100-nm curcumin lipid nanoemulsion showed the most prominent inhibitory effect on the production of tumor necrosis factor-alpha (TNF-alpha) induced by lipopolysaccharide (LPS) in RAW264.7 murine macrophages, and on the release of beta-hexosaminidase induced by the calcium ionophore, A23187, in rat basophilic leukemia RBL-2H3 cells.	Curcumin	49-57	tumor necrosis factor	Mus musculus	171-180
25862641-3	2015	Our previous studies have found that a curcumin analog, L48H37 [1-ethyl-3,5-bis(3,4,5-trimethoxybenzylidene)piperidin-4-one], was able to inhibit LPS-induced inflammation, particularly tumor necrosis factor alpha and interleukin 6 production and gene expression in mouse macrophages.	Curcumin	39-47	tumor necrosis factor	Mus musculus	185-212
25862641-3	2015	Our previous studies have found that a curcumin analog, L48H37 [1-ethyl-3,5-bis(3,4,5-trimethoxybenzylidene)piperidin-4-one], was able to inhibit LPS-induced inflammation, particularly tumor necrosis factor alpha and interleukin 6 production and gene expression in mouse macrophages.	Curcumin	39-47	interleukin 6	Mus musculus	217-230
25971429-11	2015	CONCLUSION: Our results show that curcumin inhibits the growth of androgen-independent prostate cancer cells through ERK1/2- and SAPK/JNK-mediated inhibition of p65, followed by reducing expression of MUC1-C protein.	Curcumin	34-42	mitogen-activated protein kinase 3	Homo sapiens	117-123
25673156-9	2015	These findings suggested that the protective effect of curcumin against H/R injury in the H9c2 myocytes was through the inhibition of apoptosis and autophagy by inducing the expression of Bcl-2 and inhibiting the expression levels of Bax, beclin-1, BNIP3 and SIRT1.	Curcumin	55-63	BCL2 apoptosis regulator	Homo sapiens	188-193
25673156-9	2015	These findings suggested that the protective effect of curcumin against H/R injury in the H9c2 myocytes was through the inhibition of apoptosis and autophagy by inducing the expression of Bcl-2 and inhibiting the expression levels of Bax, beclin-1, BNIP3 and SIRT1.	Curcumin	55-63	BCL2 associated X, apoptosis regulator	Homo sapiens	234-237
25673156-9	2015	These findings suggested that the protective effect of curcumin against H/R injury in the H9c2 myocytes was through the inhibition of apoptosis and autophagy by inducing the expression of Bcl-2 and inhibiting the expression levels of Bax, beclin-1, BNIP3 and SIRT1.	Curcumin	55-63	BCL2 interacting protein 3	Homo sapiens	249-254
25933946-0	2015	The protective effect of curcumin administration on carbon tetrachloride (CCl4)-induced nephrotoxicity in rats.	Curcumin	25-33	C-C motif chemokine ligand 4	Rattus norvegicus	74-78
25933946-1	2015	BACKGROUND: The aim of the present study was to examine the protective effect of curcumin (CUR) on carbon tetrachloride (CCl4)-induced nephrotoxicity to evaluate the detailed mechanisms by which CUR exerts its protective action.	Curcumin	81-89	C-C motif chemokine ligand 4	Rattus norvegicus	121-125
26942057-3	2016	Cryoablation involves killing of tumor cells through freezing and thawing, resulting in recruitment of tumor-specific T cells, while curcumin stimulates T cells through the reduction of IL-6 in the TME.	Curcumin	133-141	interleukin 6	Mus musculus	186-190
26013662-7	2015	Mechanistic investigations revealed that curcumin treatment upregulated the ER stress markers CHOP and Bip/GRP78 and the autophagic marker LC3-II.	Curcumin	41-49	DNA damage inducible transcript 3	Homo sapiens	94-98
26013662-7	2015	Mechanistic investigations revealed that curcumin treatment upregulated the ER stress markers CHOP and Bip/GRP78 and the autophagic marker LC3-II.	Curcumin	41-49	heat shock protein family A (Hsp70) member 5	Homo sapiens	103-106
26013662-7	2015	Mechanistic investigations revealed that curcumin treatment upregulated the ER stress markers CHOP and Bip/GRP78 and the autophagic marker LC3-II.	Curcumin	41-49	heat shock protein family A (Hsp70) member 5	Homo sapiens	107-112
25747863-0	2015	Curcumin, encapsulated in nano-sized PLGA, down-regulates nuclear factor kappaB (p65) and subarachnoid hemorrhage induced early brain injury in a rat model.	Curcumin	0-8	synaptotagmin 1	Rattus norvegicus	81-84
25988362-6	2015	Furthermore, such a curcumin treatment reduced CFA-induced activation of glial cells and production of inflammatory mediators [interleukin-1beta (IL-1beta), monocyte chemoattractant protein-1 (MCP-1), and monocyte inflammatory protein-1 (MIP-1alpha)] in the spinal cord.	Curcumin	20-28	interleukin 1 beta	Rattus norvegicus	127-144
25988362-6	2015	Furthermore, such a curcumin treatment reduced CFA-induced activation of glial cells and production of inflammatory mediators [interleukin-1beta (IL-1beta), monocyte chemoattractant protein-1 (MCP-1), and monocyte inflammatory protein-1 (MIP-1alpha)] in the spinal cord.	Curcumin	20-28	interleukin 1 beta	Rattus norvegicus	146-154
25988362-7	2015	Curcumin also decreased lipopolysaccharide-induced production of IL-1beta, tumor necrosis factor-alpha, MCP-1, and MIP-1alpha in cultured astrocytes and microglia.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	65-73
25988362-7	2015	Curcumin also decreased lipopolysaccharide-induced production of IL-1beta, tumor necrosis factor-alpha, MCP-1, and MIP-1alpha in cultured astrocytes and microglia.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	75-102
25971429-0	2015	Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-kappaB/p65 and MUC1-C. BACKGROUND: Prostate cancer is one of the most common malignancies in men.	Curcumin	15-23	mitogen-activated protein kinase 9	Homo sapiens	126-130
25971429-0	2015	Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-kappaB/p65 and MUC1-C. BACKGROUND: Prostate cancer is one of the most common malignancies in men.	Curcumin	15-23	mitogen-activated protein kinase 9	Homo sapiens	131-134
25971429-0	2015	Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-kappaB/p65 and MUC1-C. BACKGROUND: Prostate cancer is one of the most common malignancies in men.	Curcumin	15-23	mitogen-activated protein kinase kinase 7	Homo sapiens	139-142
25971429-0	2015	Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-kappaB/p65 and MUC1-C. BACKGROUND: Prostate cancer is one of the most common malignancies in men.	Curcumin	15-23	mitogen-activated protein kinase 3	Homo sapiens	143-149
25971429-7	2015	To further explore the potential mechanism underlining this, we found that curcumin increased the phosphorylation of ERK1/2 and SAPK/JNK, which was enhanced by bicalutamide.	Curcumin	75-83	mitogen-activated protein kinase 3	Homo sapiens	117-123
25971429-7	2015	To further explore the potential mechanism underlining this, we found that curcumin increased the phosphorylation of ERK1/2 and SAPK/JNK, which was enhanced by bicalutamide.	Curcumin	75-83	mitogen-activated protein kinase 9	Homo sapiens	128-132
25971429-7	2015	To further explore the potential mechanism underlining this, we found that curcumin increased the phosphorylation of ERK1/2 and SAPK/JNK, which was enhanced by bicalutamide.	Curcumin	75-83	mitogen-activated protein kinase 9	Homo sapiens	133-136
25971429-8	2015	In addition, curcumin reduced the protein expression of MUC1-C and NF-kappaB subunit p65, which were abrogated in the presence of the inhibitors of MEK/ERK1/2 (PD98059) and SAPK/JNK (SP60015).	Curcumin	13-21	mitogen-activated protein kinase kinase 7	Homo sapiens	148-151
25971429-8	2015	In addition, curcumin reduced the protein expression of MUC1-C and NF-kappaB subunit p65, which were abrogated in the presence of the inhibitors of MEK/ERK1/2 (PD98059) and SAPK/JNK (SP60015).	Curcumin	13-21	mitogen-activated protein kinase 3	Homo sapiens	152-158
25971429-8	2015	In addition, curcumin reduced the protein expression of MUC1-C and NF-kappaB subunit p65, which were abrogated in the presence of the inhibitors of MEK/ERK1/2 (PD98059) and SAPK/JNK (SP60015).	Curcumin	13-21	mitogen-activated protein kinase 9	Homo sapiens	173-177
25971429-8	2015	In addition, curcumin reduced the protein expression of MUC1-C and NF-kappaB subunit p65, which were abrogated in the presence of the inhibitors of MEK/ERK1/2 (PD98059) and SAPK/JNK (SP60015).	Curcumin	13-21	mitogen-activated protein kinase 9	Homo sapiens	178-181
25971429-11	2015	CONCLUSION: Our results show that curcumin inhibits the growth of androgen-independent prostate cancer cells through ERK1/2- and SAPK/JNK-mediated inhibition of p65, followed by reducing expression of MUC1-C protein.	Curcumin	34-42	mitogen-activated protein kinase 9	Homo sapiens	129-133
25971429-11	2015	CONCLUSION: Our results show that curcumin inhibits the growth of androgen-independent prostate cancer cells through ERK1/2- and SAPK/JNK-mediated inhibition of p65, followed by reducing expression of MUC1-C protein.	Curcumin	34-42	mitogen-activated protein kinase 9	Homo sapiens	134-137
25971429-13	2015	The negative feedback regulatory loop of MUC1-C to ERK1/2 and SAPK/JNK further demonstrates the role of MUC1-C that contributes to the overall responses of curcumin.	Curcumin	156-164	mitogen-activated protein kinase 3	Homo sapiens	51-57
25971429-13	2015	The negative feedback regulatory loop of MUC1-C to ERK1/2 and SAPK/JNK further demonstrates the role of MUC1-C that contributes to the overall responses of curcumin.	Curcumin	156-164	mitogen-activated protein kinase 9	Homo sapiens	62-66
25971429-13	2015	The negative feedback regulatory loop of MUC1-C to ERK1/2 and SAPK/JNK further demonstrates the role of MUC1-C that contributes to the overall responses of curcumin.	Curcumin	156-164	mitogen-activated protein kinase 9	Homo sapiens	67-70
25550171-4	2015	We report that curcumin enhances the synthesis of DHA from its precursor, alpha-linolenic acid (C18:3 n-3; ALA) and elevates levels of enzymes involved in the synthesis of DHA such as FADS2 and elongase 2 in both liver and brain tissues.	Curcumin	15-23	fatty acid desaturase 2	Homo sapiens	184-189
25867080-0	2015	Molecular Basis for Fe(III)-Independent Curcumin Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Activity.	Curcumin	40-48	CF transmembrane conductance regulator	Homo sapiens	65-116
25867080-1	2015	Curcumin potentiates the phosphorylation-dependent activity of human cystic fibrosis transmembrane conductance regulator (CFTR) in Fe(3+)-dependent and Fe(3+)-independent manners.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	69-120
25867080-1	2015	Curcumin potentiates the phosphorylation-dependent activity of human cystic fibrosis transmembrane conductance regulator (CFTR) in Fe(3+)-dependent and Fe(3+)-independent manners.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	122-126
25867080-7	2015	Curcumin may potentiate CFTR activity not only by removing inhibitory Fe(3+) to release the R domain from ICL3 but also by stabilizing the stimulatory R-ICL1/ICL4 interactions.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	24-28
25961579-0	2015	Inhibition of IL-6 signaling pathway by curcumin in uterine decidual cells.	Curcumin	40-48	interleukin 6	Homo sapiens	14-18
25961579-6	2015	Therefore, we examined the effect of curcumin on IL-6 expression using two types of uterine decidual cells 1) HuF cells, primary human fibroblast cells obtained from the decidua parietalis; 2) UIII cells, a rodent non-transformed decidual cell line.	Curcumin	37-45	interleukin 6	Homo sapiens	49-53
25961579-7	2015	Curcumin treatment completely abrogated the expression of IL-1beta-induced IL-6 in these cells.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	58-66
25961579-7	2015	Curcumin treatment completely abrogated the expression of IL-1beta-induced IL-6 in these cells.	Curcumin	0-8	interleukin 6	Homo sapiens	75-79
25961579-8	2015	Curcumin also strongly inhibited the expression of gp130, a critical molecule in IL-6 signaling, whereas expression of IL-6R and sIL-6R was not affected.	Curcumin	0-8	interleukin 6	Homo sapiens	81-85
25961579-9	2015	Curcumin also inhibited phosphorylation and nuclear localization of STAT3, a well-known downstream mediator of IL-6 signaling.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	68-73
25961579-9	2015	Curcumin also inhibited phosphorylation and nuclear localization of STAT3, a well-known downstream mediator of IL-6 signaling.	Curcumin	0-8	interleukin 6	Homo sapiens	111-115
25961579-10	2015	Furthermore, curcumin attenuated IL-1beta-induced IL-6 promoter reporter activity suggesting transcriptional regulation.	Curcumin	13-21	interleukin 1 beta	Homo sapiens	33-41
25961579-10	2015	Furthermore, curcumin attenuated IL-1beta-induced IL-6 promoter reporter activity suggesting transcriptional regulation.	Curcumin	13-21	interleukin 6	Homo sapiens	50-54
25961579-11	2015	To further understand whether NF-kB is involved in this inhibition, we examined the effect of curcumin on the expression of p50 and p65 subunits of NF-kB in decidual cells.	Curcumin	94-102	nuclear factor kappa B subunit 1	Homo sapiens	124-127
25961579-12	2015	Expression of IL-1beta-induced p50 mRNA was repressed by curcumin while p65 mRNA was not affected.	Curcumin	57-65	interleukin 1 beta	Homo sapiens	14-22
25961579-12	2015	Expression of IL-1beta-induced p50 mRNA was repressed by curcumin while p65 mRNA was not affected.	Curcumin	57-65	nuclear factor kappa B subunit 1	Homo sapiens	31-34
25961579-13	2015	However, curcumin treatment dramatically inhibited both p50 and p65 protein levels and prevented its nuclear localization.	Curcumin	9-17	nuclear factor kappa B subunit 1	Homo sapiens	56-59
25961579-14	2015	This effect is at least partly mediated through the deactivation of IKK, since IL-1beta-induced IKKalpha/beta phosphorylation is decreased upon curcumin treatment.	Curcumin	144-152	interleukin 1 beta	Homo sapiens	79-87
25883212-4	2015	We have developed the novel small molecular STAT3 inhibitor LLL12 on the basis of curcumin structure using computer-aided rational design.	Curcumin	82-90	signal transducer and activator of transcription 3	Homo sapiens	44-49
25666897-8	2015	The enhancement in curcumin fluorescence on the addition of oligomers and pre-fibrillar aggregates of SOD1 suggests binding of these species to curcumin.	Curcumin	19-27	superoxide dismutase 1	Homo sapiens	102-106
25712055-9	2015	Furthermore, we demonstrated in a mouse xenograft model that both curcumin and AKBA treatments suppressed tumor growth, which corresponded with alterations in the expression of miR-34a and miR-27a, consistent with our in vitro findings.	Curcumin	66-74	microRNA 34a	Mus musculus	177-184
25666897-8	2015	The enhancement in curcumin fluorescence on the addition of oligomers and pre-fibrillar aggregates of SOD1 suggests binding of these species to curcumin.	Curcumin	144-152	superoxide dismutase 1	Homo sapiens	102-106
25666897-9	2015	Docking studies indicate that putative binding site of curcumin may be the amyloidogenic regions of SOD1.	Curcumin	55-63	superoxide dismutase 1	Homo sapiens	100-104
25666897-0	2015	Curcumin binds to the pre-fibrillar aggregates of Cu/Zn superoxide dismutase (SOD1) and alters its amyloidogenic pathway resulting in reduced cytotoxicity.	Curcumin	0-8	superoxide dismutase 1	Homo sapiens	50-76
25666897-0	2015	Curcumin binds to the pre-fibrillar aggregates of Cu/Zn superoxide dismutase (SOD1) and alters its amyloidogenic pathway resulting in reduced cytotoxicity.	Curcumin	0-8	superoxide dismutase 1	Homo sapiens	78-82
25666897-6	2015	In the present study, we observed the fibrillation of one of the premature forms of SOD1 (SOD1 with reduced disulfide) in the presence of curcumin.	Curcumin	138-146	superoxide dismutase 1	Homo sapiens	84-88
25666897-6	2015	In the present study, we observed the fibrillation of one of the premature forms of SOD1 (SOD1 with reduced disulfide) in the presence of curcumin.	Curcumin	138-146	superoxide dismutase 1	Homo sapiens	90-94
25666897-7	2015	Using ThT binding assay, AFM, TEM images and FTIR, we demonstrate that curcumin inhibits the DTT-induced fibrillation of SOD1 and favors the formation of smaller and disordered aggregates of SOD1.	Curcumin	71-79	superoxide dismutase 1	Homo sapiens	121-125
25666897-7	2015	Using ThT binding assay, AFM, TEM images and FTIR, we demonstrate that curcumin inhibits the DTT-induced fibrillation of SOD1 and favors the formation of smaller and disordered aggregates of SOD1.	Curcumin	71-79	superoxide dismutase 1	Homo sapiens	191-195
25712055-0	2015	Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer.	Curcumin	19-27	microRNA 34a	Mus musculus	93-100
25712055-8	2015	We discovered that curcumin and AKBA induced upregulation of tumor-suppressive miR-34a and downregulation of miR-27a in colorectal cancer cells.	Curcumin	19-27	microRNA 34a	Mus musculus	79-86
25739561-19	2015	In summary, curcumin might alleviate airway inflammation in asthma through the Nrf2/HO-1 pathway, potentially making it an effective drug in asthma treatment.	Curcumin	12-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
25583641-7	2015	Further, the expression of two important cell cycle inhibitory proteins, p21 and p53, in the curcumin- and culture medium-treated cells without curcumin was evaluated by intracellular flow cytometry.	Curcumin	93-101	tumor protein p53	Homo sapiens	81-84
25765666-0	2015	Curcumin attenuates cardiomyocyte hypertrophy induced by high glucose and insulin via the PPARgamma/Akt/NO signaling pathway.	Curcumin	0-8	insulin	Homo sapiens	74-81
25765666-0	2015	Curcumin attenuates cardiomyocyte hypertrophy induced by high glucose and insulin via the PPARgamma/Akt/NO signaling pathway.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	90-99
25765666-0	2015	Curcumin attenuates cardiomyocyte hypertrophy induced by high glucose and insulin via the PPARgamma/Akt/NO signaling pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	100-103
25765666-6	2015	GW9662 (10mumol/L), a selective PPARgamma antagonist, could abolish the effects of curcumin.	Curcumin	83-91	peroxisome proliferator activated receptor gamma	Homo sapiens	32-41
25765666-8	2015	CONCLUSIONS: The results suggested that curcumin supplementation can improve HGI-induced cardiomyocytes hypertrophy in vitro through the activation of PPARgamma/Akt/NO signaling pathway.	Curcumin	40-48	peroxisome proliferator activated receptor gamma	Homo sapiens	151-160
25765666-8	2015	CONCLUSIONS: The results suggested that curcumin supplementation can improve HGI-induced cardiomyocytes hypertrophy in vitro through the activation of PPARgamma/Akt/NO signaling pathway.	Curcumin	40-48	AKT serine/threonine kinase 1	Homo sapiens	161-164
25739561-0	2015	Curcumin ameliorates asthmatic airway inflammation by activating nuclear factor-E2-related factor 2/haem oxygenase (HO)-1 signalling pathway.	Curcumin	0-8	heme oxygenase 1	Mus musculus	100-121
25739561-2	2015	However, the relationship between curcumin and the nuclear factor-E2-related factor 2 (Nrf2)/haem oxygenase (HO)-1 pathway in asthma treatment remains unknown.	Curcumin	34-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	87-91
25739561-16	2015	Haem oxygenase-1 and nuclear Nrf2 levels were enhanced in dose- and time-dependent manners in curcumin-treated RAW264.7 cells.	Curcumin	94-102	nuclear factor, erythroid derived 2, like 2	Mus musculus	29-33
25739561-17	2015	Curcumin blocked lipopolysaccharide-upregulated expression of tumour necrosis factor-alpha, IL-1beta, and IL-6.	Curcumin	0-8	interleukin 1 beta	Mus musculus	92-100
25739561-17	2015	Curcumin blocked lipopolysaccharide-upregulated expression of tumour necrosis factor-alpha, IL-1beta, and IL-6.	Curcumin	0-8	interleukin 6	Mus musculus	106-110
25583641-10	2015	Flow cytometry analysis showed a twofold increase in the expression of both p21 and p53 in curcumin-treated cells as compared to the medium-treated cells, suggesting that curcumin inhibits EPC growth by mainly inhibiting the G1 to S phase transition in the cell cycle.	Curcumin	91-99	tumor protein p53	Homo sapiens	84-87
25583641-10	2015	Flow cytometry analysis showed a twofold increase in the expression of both p21 and p53 in curcumin-treated cells as compared to the medium-treated cells, suggesting that curcumin inhibits EPC growth by mainly inhibiting the G1 to S phase transition in the cell cycle.	Curcumin	171-179	tumor protein p53	Homo sapiens	84-87
25510836-9	2015	The administration of curcumin at 100 mg/kg during the 12 weeks markedly decreased the expression of PCNA, Bcl-2, SOCS1 e -3, and STAT3.	Curcumin	22-30	BCL2, apoptosis regulator	Rattus norvegicus	107-112
25860111-3	2015	The results support the view that fitting of curcumin and PCI-34058 within the HDAC1 pocket depends on extensive interactions between the aromatic moieties of the inhibitors and the extensive network of aromatic amino acid side chains lining the pocket of HDAC1.	Curcumin	45-53	histone deacetylase 1	Homo sapiens	79-84
25860111-3	2015	The results support the view that fitting of curcumin and PCI-34058 within the HDAC1 pocket depends on extensive interactions between the aromatic moieties of the inhibitors and the extensive network of aromatic amino acid side chains lining the pocket of HDAC1.	Curcumin	45-53	histone deacetylase 1	Homo sapiens	256-261
25860111-6	2015	In conclusion, curcumin and PCI-34058-mediated ligand-dependent HDAC1 tunnel closure interferes negatively with the ASP-HIS charge relay system in HDAC1.	Curcumin	15-23	histone deacetylase 1	Homo sapiens	64-69
25860111-6	2015	In conclusion, curcumin and PCI-34058-mediated ligand-dependent HDAC1 tunnel closure interferes negatively with the ASP-HIS charge relay system in HDAC1.	Curcumin	15-23	histone deacetylase 1	Homo sapiens	147-152
26018265-4	2015	Curcumin treatment significantly reduced H3K9 acetylation level at Egr-1 binding site and decreased both the binding of Egr-1 to promoter region II and gdnf mRNA levels in C6 astroglioma cells (P&lt;0.05).	Curcumin	0-8	early growth response 1	Rattus norvegicus	67-72
26018265-4	2015	Curcumin treatment significantly reduced H3K9 acetylation level at Egr-1 binding site and decreased both the binding of Egr-1 to promoter region II and gdnf mRNA levels in C6 astroglioma cells (P&lt;0.05).	Curcumin	0-8	early growth response 1	Rattus norvegicus	120-125
25910231-3	2015	In the current manuscript, we investigated the mechanism of curcumin-induced apoptosis in upper aerodigestive tract cancer cell lines and showed that curcumin-induced apoptosis is mediated by the modulation of multiple pathways such as induction of p73, and inhibition of p-AKT and Bcl-2.	Curcumin	60-68	AKT serine/threonine kinase 1	Homo sapiens	274-277
25910231-3	2015	In the current manuscript, we investigated the mechanism of curcumin-induced apoptosis in upper aerodigestive tract cancer cell lines and showed that curcumin-induced apoptosis is mediated by the modulation of multiple pathways such as induction of p73, and inhibition of p-AKT and Bcl-2.	Curcumin	60-68	BCL2 apoptosis regulator	Homo sapiens	282-287
25910231-3	2015	In the current manuscript, we investigated the mechanism of curcumin-induced apoptosis in upper aerodigestive tract cancer cell lines and showed that curcumin-induced apoptosis is mediated by the modulation of multiple pathways such as induction of p73, and inhibition of p-AKT and Bcl-2.	Curcumin	150-158	AKT serine/threonine kinase 1	Homo sapiens	274-277
25966111-7	2015	Curcumin had a therapeutic effect, which probably played a role in UC treatment by inhibiting the p38MAPK signaling pathway, thereby reducing the release of TNF-alpha.	Curcumin	0-8	tumor necrosis factor	Mus musculus	157-166
25910231-3	2015	In the current manuscript, we investigated the mechanism of curcumin-induced apoptosis in upper aerodigestive tract cancer cell lines and showed that curcumin-induced apoptosis is mediated by the modulation of multiple pathways such as induction of p73, and inhibition of p-AKT and Bcl-2.	Curcumin	150-158	BCL2 apoptosis regulator	Homo sapiens	282-287
25910231-4	2015	Treatment of cells with curcumin induced both p53 and the related protein p73 in head and neck and lung cancer cell lines.	Curcumin	24-32	tumor protein p53	Homo sapiens	46-49
25910231-6	2015	Curcumin treatment also strongly inhibited p-AKT and Bcl-2 and overexpression of constitutively active AKT or Bcl-2 significantly inhibited curcumin-induced apoptosis.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	45-48
25910231-6	2015	Curcumin treatment also strongly inhibited p-AKT and Bcl-2 and overexpression of constitutively active AKT or Bcl-2 significantly inhibited curcumin-induced apoptosis.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	53-58
25910231-6	2015	Curcumin treatment also strongly inhibited p-AKT and Bcl-2 and overexpression of constitutively active AKT or Bcl-2 significantly inhibited curcumin-induced apoptosis.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	110-115
25910231-6	2015	Curcumin treatment also strongly inhibited p-AKT and Bcl-2 and overexpression of constitutively active AKT or Bcl-2 significantly inhibited curcumin-induced apoptosis.	Curcumin	140-148	AKT serine/threonine kinase 1	Homo sapiens	103-106
25910231-6	2015	Curcumin treatment also strongly inhibited p-AKT and Bcl-2 and overexpression of constitutively active AKT or Bcl-2 significantly inhibited curcumin-induced apoptosis.	Curcumin	140-148	BCL2 apoptosis regulator	Homo sapiens	110-115
25910231-7	2015	Taken together, our findings suggest that curcumin-induced apoptosis is mediated via activating tumor suppressor p73 and inhibiting p-AKT and Bcl-2.	Curcumin	42-50	AKT serine/threonine kinase 1	Homo sapiens	134-137
25910231-7	2015	Taken together, our findings suggest that curcumin-induced apoptosis is mediated via activating tumor suppressor p73 and inhibiting p-AKT and Bcl-2.	Curcumin	42-50	BCL2 apoptosis regulator	Homo sapiens	142-147
25860911-0	2015	Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of inflammation in prevention of cancer.	Curcumin	20-28	nuclear factor, erythroid derived 2, like 2	Mus musculus	120-124
25860911-3	2015	Present study was designed to investigate long term effect of curcumin in regulation of Nrf2 mediated phase-II antioxidant enzymes, tumour suppressor p53 and inflammation under oxidative tumour microenvironment in liver of T-cell lymphoma bearing mice.	Curcumin	62-70	nuclear factor, erythroid derived 2, like 2	Mus musculus	88-92
25860911-5	2015	Curcumin potentiated significant increase in Nrf2 activation.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49
25860911-7	2015	In addition, curcumin modulated inflammation via upregulation of TGF-beta and reciprocal regulation of iNOS and COX2.	Curcumin	13-21	nitric oxide synthase 2, inducible	Mus musculus	103-107
25860911-8	2015	The study suggests that during long term effect, curcumin leads to prevention of cancer by inducing phase-II antioxidant enzymes via activation of Nrf2 signalling, restoration of tumour suppressor p53 and modulation of inflammatory mediators like iNOS and COX2 in liver of lymphoma bearing mice.	Curcumin	49-57	nuclear factor, erythroid derived 2, like 2	Mus musculus	147-151
25860911-8	2015	The study suggests that during long term effect, curcumin leads to prevention of cancer by inducing phase-II antioxidant enzymes via activation of Nrf2 signalling, restoration of tumour suppressor p53 and modulation of inflammatory mediators like iNOS and COX2 in liver of lymphoma bearing mice.	Curcumin	49-57	nitric oxide synthase 2, inducible	Mus musculus	247-251
25753330-0	2015	Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects.	Curcumin	6-14	epidermal growth factor receptor	Homo sapiens	35-39
25779681-1	2015	The complexation of nanoparticles in unheated and heated (at 75-95 ) soy protein isolate (SPI) with curcumin and the effects on curcumin stability/bioaccessibility and in vitro protein digestibility were investigated.	Curcumin	100-108	chromogranin A	Homo sapiens	90-93
24793792-6	2015	Curcumin, an AP-1 inhibitor, was also found to regulate PGRN promoter activity and expression including its downstream effectors aforementioned.	Curcumin	0-8	granulin precursor	Homo sapiens	56-60
24793792-11	2015	Our data suggest that a new strategy combining current regimens with compounds targeting PGRN/AP-1 loop like curcumin may significantly improve the therapeutic outcome of GBM.	Curcumin	109-117	granulin precursor	Homo sapiens	89-93
25856395-4	2015	Pre-treatment with curcumin prevented disruption of the mucosal barrier by maintaining ZO-1 and occludin expression and maintained trans-epithelial electric resistance across the genital epithelium.	Curcumin	19-27	tight junction protein 1	Homo sapiens	87-91
25856395-5	2015	Curcumin pre-treatment also abrogated the gp120-mediated upregulation of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin (IL)-6, which mediate barrier disruption, as well as the chemokines IL-8, RANTES and interferon gamma-induced protein-10 (IP-10), which are capable of recruiting HIV target cells to the FGT.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	103-130
25856395-5	2015	Curcumin pre-treatment also abrogated the gp120-mediated upregulation of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin (IL)-6, which mediate barrier disruption, as well as the chemokines IL-8, RANTES and interferon gamma-induced protein-10 (IP-10), which are capable of recruiting HIV target cells to the FGT.	Curcumin	0-8	interleukin 6	Homo sapiens	135-153
25856395-5	2015	Curcumin pre-treatment also abrogated the gp120-mediated upregulation of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin (IL)-6, which mediate barrier disruption, as well as the chemokines IL-8, RANTES and interferon gamma-induced protein-10 (IP-10), which are capable of recruiting HIV target cells to the FGT.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	215-219
25960232-0	2015	Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells.	Curcumin	62-70	BCL2 apoptosis regulator	Homo sapiens	92-97
25960232-2	2015	Curcumin triggers intrinsic apoptotic cell death by activating mitochondrial permeabilization due to the altered expression of pro- and anti-apoptotic Bcl-2 family members.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	151-156
25960232-4	2015	We found that Bcl-2 overexpression is a limiting factor for curcumin-induced apoptosis in highly metastatic MCF-7 breast cancer cells.	Curcumin	60-68	BCL2 apoptosis regulator	Homo sapiens	14-19
25753330-0	2015	Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects.	Curcumin	6-14	epidermal growth factor receptor	Homo sapiens	91-95
25753330-1	2015	Curcumin (1) down-regulates the expression as well as phosphorylation of epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells expressing gefitinib-resistant EGFR.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	73-105
25753330-1	2015	Curcumin (1) down-regulates the expression as well as phosphorylation of epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells expressing gefitinib-resistant EGFR.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	107-111
25753330-1	2015	Curcumin (1) down-regulates the expression as well as phosphorylation of epidermal growth factor receptor (EGFR) in lung adenocarcinoma cells expressing gefitinib-resistant EGFR.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	173-177
25753330-6	2015	Among all evaluated curcumin derivatives, compound 2 showed the best inhibitory effects on both wild-type and mutant EGFR by efficiently inducing gefitinib-insensitive EGFR degradation.	Curcumin	20-28	epidermal growth factor receptor	Homo sapiens	117-121
25960232-5	2015	Forced overexpression of Bcl-2 also blocked curcumin-induced autophagy in MCF-7 cells, through its inhibitory interactions with Beclin-1.	Curcumin	44-52	BCL2 apoptosis regulator	Homo sapiens	25-30
25682767-3	2015	Here, we report that topical use of a curcumin gel formulation inhibited TPA-induced Th1 inflammation in K14-VEGF transgenic mice ears but not Th17 inflammation as expected.	Curcumin	38-46	negative elongation factor complex member C/D, Th1l	Mus musculus	85-88
25960232-6	2015	Pre-treatment of PI3K inhibitor LY294002 enhanced curcumin-induced cell death, apoptosis, and autophagy via modulating the expression of Bcl-2 family members and autophagosome formation in MCF-7 breast cancer cells.	Curcumin	50-58	BCL2 apoptosis regulator	Homo sapiens	137-142
25960232-7	2015	Atg7 silencing further increased apoptotic potential of curcumin in the presence or absence of LY294002 in wt and Bcl-2+ MCF-7 cells.	Curcumin	56-64	BCL2 apoptosis regulator	Homo sapiens	114-119
25960232-8	2015	The findings of this study support the hypothesis that blocking the PI3K/Akt pathway may further increased curcumin-induced apoptosis and overcome forced Bcl-2 expression level mediated autophagic responses against curcumin treatment in MCF-7 cells.	Curcumin	107-115	AKT serine/threonine kinase 1	Homo sapiens	73-76
25960232-8	2015	The findings of this study support the hypothesis that blocking the PI3K/Akt pathway may further increased curcumin-induced apoptosis and overcome forced Bcl-2 expression level mediated autophagic responses against curcumin treatment in MCF-7 cells.	Curcumin	215-223	AKT serine/threonine kinase 1	Homo sapiens	73-76
25960232-8	2015	The findings of this study support the hypothesis that blocking the PI3K/Akt pathway may further increased curcumin-induced apoptosis and overcome forced Bcl-2 expression level mediated autophagic responses against curcumin treatment in MCF-7 cells.	Curcumin	215-223	BCL2 apoptosis regulator	Homo sapiens	154-159
25780454-0	2015	Curcumin improves the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cells via the NF-kappaB-p53-caspase-3 pathway.	Curcumin	0-8	tumor protein p53	Homo sapiens	113-116
25780454-8	2015	The expression levels of p53 protein and cleaved caspase-3 were increased significantly in the curcumin plus paclitaxel-treated HeLa and CaSki cells compared with those in the cells treated with paclitaxel alone (P&lt;0.01).	Curcumin	95-103	tumor protein p53	Homo sapiens	25-28
25780454-9	2015	Significant reductions in the levels of phosphorylation of IkappaBalpha and the p65-NF-kappaB subunit in CaSki cells treated with curcumin and paclitaxel were observed compared with those in cells treated with paclitaxel alone (P&lt;0.05).	Curcumin	130-138	NFKB inhibitor alpha	Homo sapiens	59-71
25780454-10	2015	This suggests that the combined effect of curcumin and paclitaxel was associated with the NF-kappaB-p53-caspase-3 pathway.	Curcumin	42-50	tumor protein p53	Homo sapiens	100-103
25780454-11	2015	In conclusion, curcumin has the ability to improve the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cell lines via the NF-kappaB-p53-caspase-3 pathway.	Curcumin	15-23	tumor protein p53	Homo sapiens	151-154
25284464-7	2015	Finally, for a more radical approach towards a safe MEK inhibitor, we validate the potential of multi-kinase inhibitor curcumin, especially the nano-curcumin made out of pure curcumin with greater bioavailability; in repealing tumour-shed TGF-beta-induced Treg cell augmentation.	Curcumin	119-127	transforming growth factor beta 1	Homo sapiens	239-247
25730179-11	2015	Curcumin treatment exerted anti-apoptosis and anti-oxidative effects by up-regulating Nrf2/HO-1 and Sirt1 expression.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	86-90
25730179-11	2015	Curcumin treatment exerted anti-apoptosis and anti-oxidative effects by up-regulating Nrf2/HO-1 and Sirt1 expression.	Curcumin	0-8	sirtuin 1	Rattus norvegicus	100-105
25587128-7	2015	Oral curcumin (2000 mg) and lapatinib (250 mg) are the best available clinical BCRP inhibitors.	Curcumin	5-13	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	79-83
25912594-1	2015	OBJECTIVE: To observe the effect of curcumin on the expression levels of nuclear factor kappaB-p65 (NF-kappaB-p65) and tumour necrosis factor alpha (TNF-alpha) in the nucleus pulposus in rats with lumbar intervertebral disc degeneration.	Curcumin	36-44	synaptotagmin 1	Rattus norvegicus	95-98
25912594-1	2015	OBJECTIVE: To observe the effect of curcumin on the expression levels of nuclear factor kappaB-p65 (NF-kappaB-p65) and tumour necrosis factor alpha (TNF-alpha) in the nucleus pulposus in rats with lumbar intervertebral disc degeneration.	Curcumin	36-44	synaptotagmin 1	Rattus norvegicus	110-113
25912594-1	2015	OBJECTIVE: To observe the effect of curcumin on the expression levels of nuclear factor kappaB-p65 (NF-kappaB-p65) and tumour necrosis factor alpha (TNF-alpha) in the nucleus pulposus in rats with lumbar intervertebral disc degeneration.	Curcumin	36-44	tumor necrosis factor	Rattus norvegicus	149-158
25912594-9	2015	Based on the results of Western blot analysis and real-time PCR, the curcumin treatment (low dose and high dose) significantly reduced the expression levels of NF-kappaB-p65 and TNF-alpha in the lumbar intervertebral disc tissue compared with the groups without curcumin treatment and with the DMSO treatment alone.	Curcumin	69-77	synaptotagmin 1	Rattus norvegicus	170-173
25912594-9	2015	Based on the results of Western blot analysis and real-time PCR, the curcumin treatment (low dose and high dose) significantly reduced the expression levels of NF-kappaB-p65 and TNF-alpha in the lumbar intervertebral disc tissue compared with the groups without curcumin treatment and with the DMSO treatment alone.	Curcumin	69-77	tumor necrosis factor	Rattus norvegicus	178-187
25912594-11	2015	CONCLUSIONS: Curcumin may inhibit the activation of NF-kappaB by inhibiting the translocation of NF-kappaB-p65 and reducing the release of inflammatory factors which, thereby, decelerates the process of lumbar intervertebral disc degeneration.	Curcumin	13-21	synaptotagmin 1	Rattus norvegicus	107-110
25682767-0	2015	Curcumin relieves TPA-induced Th1 inflammation in K14-VEGF transgenic mice.	Curcumin	0-8	negative elongation factor complex member C/D, Th1l	Mus musculus	30-33
25682767-6	2015	We find that curcumin is capable of relieving TPA-induced inflammation by directly down-regulating IFNgamma production.	Curcumin	13-21	interferon gamma	Mus musculus	99-107
25682767-7	2015	In conclusion, curcumin inhibits TPA-induced Th1 inflammation in K14-VEGF transgenic mice which has not been previously described.	Curcumin	15-23	negative elongation factor complex member C/D, Th1l	Mus musculus	45-48
24476216-7	2015	When 5-FU incubations were repeated with the addition of curcumin, the LD50 value increased to 200-300 muM, representing a 7-10-fold protection by curcumin against 5-FU cytotoxicity.	Curcumin	57-65	latexin	Homo sapiens	103-106
26020187-11	2015	Additionally, when compared to the heat-stressed group, mitochondrial transcription factor A mRNA levels were increased (P &lt; 0.05) by 17.64% in the 200 mg/kg curcumin supplemented group.	Curcumin	161-169	transcription factor A, mitochondrial	Homo sapiens	56-92
24926560-0	2015	Curcumin increases gelatinase activity in human neutrophils by a p38 mitogen-activated protein kinase (MAPK)-independent mechanism.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	65-68
24926560-2	2015	For example, curcumin was found to induce apoptosis in neutrophils by a p38 mitogen-activated protein kinase (MAPK)-dependent mechanism.	Curcumin	13-21	mitogen-activated protein kinase 14	Homo sapiens	72-75
24926560-7	2015	The results indicate that curcumin increased the cell surface expression of CD35 (secretory vesicle), CD63 (azurophilic granules), and CD66b (gelatinase granules) in neutrophils.	Curcumin	26-34	CEA cell adhesion molecule 8	Homo sapiens	135-140
24926560-8	2015	Also, curcumin increased the release and enzymatic activity of gelatinase B in the extracellular milieu and activated p38 MAP kinase in these cells.	Curcumin	6-14	mitogen-activated protein kinase 14	Homo sapiens	118-121
24476216-7	2015	When 5-FU incubations were repeated with the addition of curcumin, the LD50 value increased to 200-300 muM, representing a 7-10-fold protection by curcumin against 5-FU cytotoxicity.	Curcumin	147-155	latexin	Homo sapiens	103-106
25644785-5	2015	Both Diclofenac and Curcumin downregulated the PI3-K and Akt expression while promoting the apoptotic mechanism.	Curcumin	20-28	AKT serine/threonine kinase 1	Rattus norvegicus	57-60
25502175-3	2015	In addition, curcumin and tetrahydrocurcumin significantly inhibited the release of prominent cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6); however, hexahydrocurcumin and octahydrocurcumin did not significantly alter cytokine release.	Curcumin	13-21	tumor necrosis factor	Mus musculus	115-142
25502175-3	2015	In addition, curcumin and tetrahydrocurcumin significantly inhibited the release of prominent cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6); however, hexahydrocurcumin and octahydrocurcumin did not significantly alter cytokine release.	Curcumin	13-21	tumor necrosis factor	Mus musculus	144-153
25502175-3	2015	In addition, curcumin and tetrahydrocurcumin significantly inhibited the release of prominent cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6); however, hexahydrocurcumin and octahydrocurcumin did not significantly alter cytokine release.	Curcumin	13-21	interleukin 6	Mus musculus	159-172
25502175-3	2015	In addition, curcumin and tetrahydrocurcumin significantly inhibited the release of prominent cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6); however, hexahydrocurcumin and octahydrocurcumin did not significantly alter cytokine release.	Curcumin	13-21	interleukin 6	Mus musculus	174-178
25502175-4	2015	Furthermore, the present study investigated the effect of curcumin and its metabolites on the expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) and activated-nuclear factor kappa B (NF-kappaB); the results showed that curcumin and its three metabolites significantly inhibited LPS-mediated upregulation of iNOS and COX-2 as well as NF-kappaB activation.	Curcumin	58-66	nitric oxide synthase 2, inducible	Mus musculus	108-129
25502175-4	2015	Furthermore, the present study investigated the effect of curcumin and its metabolites on the expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) and activated-nuclear factor kappa B (NF-kappaB); the results showed that curcumin and its three metabolites significantly inhibited LPS-mediated upregulation of iNOS and COX-2 as well as NF-kappaB activation.	Curcumin	58-66	nitric oxide synthase 2, inducible	Mus musculus	131-135
25502175-4	2015	Furthermore, the present study investigated the effect of curcumin and its metabolites on the expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) and activated-nuclear factor kappa B (NF-kappaB); the results showed that curcumin and its three metabolites significantly inhibited LPS-mediated upregulation of iNOS and COX-2 as well as NF-kappaB activation.	Curcumin	58-66	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	167-199
25502175-6	2015	In conclusion, the results of the present study demonstrated that curcumin and its major metabolites inhibited the LPS-induced inflammatory response via the mechanism of inhibiting NF-kappaB translocation to the nucleus.	Curcumin	66-74	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	181-190
25644785-10	2015	Diclofenac and Curcumin showed anti-neoplastic effects by downregulating PI3-K/Akt/PTEN pathway, inducing apoptosis, increasing ROS generation, and decreasing DeltaPsi M. The anti-neoplastic and apoptotic effects were found enhanced when both Diclofenac and Curcumin were administered together, rather than individually.	Curcumin	15-23	AKT serine/threonine kinase 1	Rattus norvegicus	79-82
25644785-6	2015	Diclofenac and Curcumin administration significantly increased the expression of pro-apoptotic Bcl-2 family members (Bad and Bax) while decreasing the anti-apoptotic Bcl-2 protein.	Curcumin	15-23	BCL2, apoptosis regulator	Rattus norvegicus	95-100
25644785-6	2015	Diclofenac and Curcumin administration significantly increased the expression of pro-apoptotic Bcl-2 family members (Bad and Bax) while decreasing the anti-apoptotic Bcl-2 protein.	Curcumin	15-23	BCL2, apoptosis regulator	Rattus norvegicus	166-171
25644785-8	2015	Diclofenac and Curcumin inhibited the Bcl-2 protein by directly interacting at the active site by multiple hydrogen bonding, as also evident by negative glide score of Bcl-2.	Curcumin	15-23	BCL2, apoptosis regulator	Rattus norvegicus	38-43
25644785-8	2015	Diclofenac and Curcumin inhibited the Bcl-2 protein by directly interacting at the active site by multiple hydrogen bonding, as also evident by negative glide score of Bcl-2.	Curcumin	15-23	BCL2, apoptosis regulator	Rattus norvegicus	168-173
25712644-9	2015	Various dosage of Curcumin attenuated these effects by significantly lowering lipid peroxidation, GSSG level, Bax concentration, caspase-3 and caspase-9 activities, while increasing superoxide dismutase and glutathione peroxidase activity, GSH level and Bcl-2 concentration.	Curcumin	18-26	caspase 9	Rattus norvegicus	143-152
25789029-0	2015	A preliminary study of the effect of curcumin on the expression of p53 protein in a human multiple myeloma cell line.	Curcumin	37-45	tumor protein p53	Homo sapiens	67-70
25789029-5	2015	The expression of p53 protein in the MM RPMI 8226 cells following treatment with curcumin was detected by western blotting and ELISA.	Curcumin	81-89	tumor protein p53	Homo sapiens	18-21
25789029-7	2015	In the MM RPMI 8226 cells treated with curcumin, the expression of the p53 and Bax genes was upregulated, while the expression of the MDM2 gene was downregulated.	Curcumin	39-47	tumor protein p53	Homo sapiens	71-74
25789029-7	2015	In the MM RPMI 8226 cells treated with curcumin, the expression of the p53 and Bax genes was upregulated, while the expression of the MDM2 gene was downregulated.	Curcumin	39-47	BCL2 associated X, apoptosis regulator	Homo sapiens	79-82
25789029-8	2015	p53 protein expression was higher in the curcumin experimental group compared with the control group.	Curcumin	41-49	tumor protein p53	Homo sapiens	0-3
25789029-10	2015	In the MM RPMI 8226 cells treated with curcumin, p53 protein levels were upregulated, which suggested that curcumin may promote the apoptosis of MM cells by upregulating p53 protein expression.	Curcumin	39-47	tumor protein p53	Homo sapiens	49-52
25789029-10	2015	In the MM RPMI 8226 cells treated with curcumin, p53 protein levels were upregulated, which suggested that curcumin may promote the apoptosis of MM cells by upregulating p53 protein expression.	Curcumin	39-47	tumor protein p53	Homo sapiens	170-173
25789029-10	2015	In the MM RPMI 8226 cells treated with curcumin, p53 protein levels were upregulated, which suggested that curcumin may promote the apoptosis of MM cells by upregulating p53 protein expression.	Curcumin	107-115	tumor protein p53	Homo sapiens	49-52
25789029-10	2015	In the MM RPMI 8226 cells treated with curcumin, p53 protein levels were upregulated, which suggested that curcumin may promote the apoptosis of MM cells by upregulating p53 protein expression.	Curcumin	107-115	tumor protein p53	Homo sapiens	170-173
25712644-9	2015	Various dosage of Curcumin attenuated these effects by significantly lowering lipid peroxidation, GSSG level, Bax concentration, caspase-3 and caspase-9 activities, while increasing superoxide dismutase and glutathione peroxidase activity, GSH level and Bcl-2 concentration.	Curcumin	18-26	BCL2, apoptosis regulator	Rattus norvegicus	254-259
25542083-5	2015	While curcumin inhibited STAT3, NFkappaB and PI3K/Akt to affect survival, temozolomide-induced autophagy relied on the DNA damage response and repair components ATM and MSH6, as well as p38 and JNK1/2.	Curcumin	6-14	signal transducer and activator of transcription 3	Homo sapiens	25-30
25542083-5	2015	While curcumin inhibited STAT3, NFkappaB and PI3K/Akt to affect survival, temozolomide-induced autophagy relied on the DNA damage response and repair components ATM and MSH6, as well as p38 and JNK1/2.	Curcumin	6-14	nuclear factor kappa B subunit 1	Homo sapiens	32-40
25542083-5	2015	While curcumin inhibited STAT3, NFkappaB and PI3K/Akt to affect survival, temozolomide-induced autophagy relied on the DNA damage response and repair components ATM and MSH6, as well as p38 and JNK1/2.	Curcumin	6-14	AKT serine/threonine kinase 1	Homo sapiens	50-53
25542083-6	2015	However, the most interesting observation was that both temozolomide and curcumin required ERK1/2 to induce autophagy.	Curcumin	73-81	mitogen-activated protein kinase 3	Homo sapiens	91-97
25822711-4	2015	Curcumin sustained the LIF independent self-renewal of mESCs and induced pluripotent stem cells (miPSCs) in a STAT3 activity dependent manner.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	110-115
25542083-7	2015	Blocking this ERK1/2-mediated temozolomide and curcumin induced autophagy with resveratrol, a blood-brain barrier permeable drug, improved temozolomide/curcumin efficacy in brain-implanted tumors.	Curcumin	47-55	mitogen-activated protein kinase 3	Homo sapiens	14-20
25542083-7	2015	Blocking this ERK1/2-mediated temozolomide and curcumin induced autophagy with resveratrol, a blood-brain barrier permeable drug, improved temozolomide/curcumin efficacy in brain-implanted tumors.	Curcumin	152-160	mitogen-activated protein kinase 3	Homo sapiens	14-20
25889862-5	2015	METHODS: A series of new curcumin analogs were synthesized and screened for their inhibitory effects on the production of TNF-alpha and IL-6 in mouse peritoneal macrophages by ELISA.	Curcumin	25-33	tumor necrosis factor	Mus musculus	122-131
25889862-5	2015	METHODS: A series of new curcumin analogs were synthesized and screened for their inhibitory effects on the production of TNF-alpha and IL-6 in mouse peritoneal macrophages by ELISA.	Curcumin	25-33	interleukin 6	Mus musculus	136-140
25786122-0	2015	Curcumin and emodin down-regulate TGF-beta signaling pathway in human cervical cancer cells.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	34-42
25786122-5	2015	Since TGF-beta and Wnt/beta-catenin signaling pathways are known to cross talk having common downstream targets, we analyzed the effect of TGF-beta on beta-catenin (an important player in Wnt/beta-catenin signaling) and also studied whether curcumin and emodin modulate them.	Curcumin	241-249	transforming growth factor beta 1	Homo sapiens	6-14
25786122-4	2015	The main objective of this work was to study the effect of curcumin and emodin on TGF-beta signaling pathway and its functional relevance to growth, migration and invasion in two cervical cancer cell lines, SiHa and HeLa.	Curcumin	59-67	transforming growth factor beta 1	Homo sapiens	82-90
25786122-6	2015	We observed that curcumin and emodin effectively down regulate TGF-beta signaling pathway by decreasing the expression of TGF-beta Receptor II, P-Smad3 and Smad4, and also counterbalance the tumorigenic effects of TGF-beta by inhibiting the TGF-beta-induced migration and invasion.	Curcumin	17-25	transforming growth factor beta 1	Homo sapiens	63-71
25573684-6	2015	SCC cell lines are treated with curcumin to regulate PIAS3 expression and cell growth.	Curcumin	32-40	protein inhibitor of activated STAT 3	Homo sapiens	53-58
25786122-6	2015	We observed that curcumin and emodin effectively down regulate TGF-beta signaling pathway by decreasing the expression of TGF-beta Receptor II, P-Smad3 and Smad4, and also counterbalance the tumorigenic effects of TGF-beta by inhibiting the TGF-beta-induced migration and invasion.	Curcumin	17-25	transforming growth factor beta 1	Homo sapiens	122-130
25786122-6	2015	We observed that curcumin and emodin effectively down regulate TGF-beta signaling pathway by decreasing the expression of TGF-beta Receptor II, P-Smad3 and Smad4, and also counterbalance the tumorigenic effects of TGF-beta by inhibiting the TGF-beta-induced migration and invasion.	Curcumin	17-25	transforming growth factor beta 1	Homo sapiens	122-130
25786122-6	2015	We observed that curcumin and emodin effectively down regulate TGF-beta signaling pathway by decreasing the expression of TGF-beta Receptor II, P-Smad3 and Smad4, and also counterbalance the tumorigenic effects of TGF-beta by inhibiting the TGF-beta-induced migration and invasion.	Curcumin	17-25	transforming growth factor beta 1	Homo sapiens	122-130
25786122-7	2015	Expression of downstream effectors of TGF-beta signaling pathway, cyclinD1, p21 and Pin1, was inhibited along with the down regulation of key mesenchymal markers (Snail and Slug) upon curcumin and emodin treatment.	Curcumin	184-192	transforming growth factor beta 1	Homo sapiens	38-46
25644192-8	2015	Curcumin-induced DNA methyltransferase 2 (DNMT2) upregulation was also shown.	Curcumin	0-8	tRNA aspartic acid methyltransferase 1	Homo sapiens	17-40
25644192-8	2015	Curcumin-induced DNA methyltransferase 2 (DNMT2) upregulation was also shown.	Curcumin	0-8	tRNA aspartic acid methyltransferase 1	Homo sapiens	42-47
25644192-9	2015	DNMT2-mediated RNA methylation could promote RNA stabilization upon curcumin treatment.	Curcumin	68-76	tRNA aspartic acid methyltransferase 1	Homo sapiens	0-5
25640947-0	2015	Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1.	Curcumin	0-8	DLEC1 cilia and flagella associated protein	Homo sapiens	145-150
25653233-10	2015	Curcumin suppressed EMT in 5FUR cells by downregulating BMI1, SUZ12 and EZH2 transcripts, key mediators of cancer stemness-related polycomb repressive complex subunits.	Curcumin	0-8	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	72-76
25573684-9	2015	Curcumin treatment increased endogenous PIAS3 expression and decreased cell growth and viability in Calu-1 cells, a model of SCC.	Curcumin	0-8	protein inhibitor of activated STAT 3	Homo sapiens	40-45
24621048-0	2015	Curcumin modulates TLR4/NF-kappaB inflammatory signaling pathway following traumatic spinal cord injury in rats.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	19-23
25619943-4	2015	In cultured hepatocytes roasted curcumin as well as 4-vinyl guaiacol enhanced the transactivation of the redox-regulated transcription factor Nrf2, known to be centrally involved in cellular stress response and antioxidant defense mechanisms.	Curcumin	32-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	142-146
25619943-5	2015	The antioxidant enzyme paraoxonase 1 was induced by roasted curcumin and 4-vinyl guaiacol.	Curcumin	60-68	paraoxonase 1	Mus musculus	23-36
25619943-6	2015	Furthermore, roasted curcumin and 4-vinyl guaiacol decreased interleukin-6 gene expression in lipopolysaccharide stimulated murine macrophages.	Curcumin	21-29	interleukin 6	Mus musculus	61-74
25536420-4	2015	Moreover, treatment with curcumin markedly decreased the sub-arm of the UPR signaling protein such as phospho-double-stranded RNA-dependent protein kinase-like ER kinase, CCAAT/enhancer-binding protein homologous protein, tumor necrosis factor receptor-associated factor 2, and inositol-requiring enzyme1alpha; and inhibited tumor necrosis factor alpha, interleukin 1beta, phospho-p38 mitogen-activated protein kinase, and apoptosis signal-regulating kinase 1 in liver tissues of diabetic rats.	Curcumin	25-33	interleukin 1 beta	Rattus norvegicus	354-371
25536420-4	2015	Moreover, treatment with curcumin markedly decreased the sub-arm of the UPR signaling protein such as phospho-double-stranded RNA-dependent protein kinase-like ER kinase, CCAAT/enhancer-binding protein homologous protein, tumor necrosis factor receptor-associated factor 2, and inositol-requiring enzyme1alpha; and inhibited tumor necrosis factor alpha, interleukin 1beta, phospho-p38 mitogen-activated protein kinase, and apoptosis signal-regulating kinase 1 in liver tissues of diabetic rats.	Curcumin	25-33	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	423-459
26307824-0	2015	Intracellular Uptake of Curcumin-Loaded Solid Lipid Nanoparticles Exhibit Anti-Inflammatory Activities Superior to Those of Curcumin Through the NF-kappaB Signaling Pathway.	Curcumin	24-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-154
24621048-2	2015	This study was designed to detect whether curcumin modulates toll-like receptor 4 (TLR4) and the nuclear factor-kappa B (NF-kappaB) inflammatory signaling pathway in the injured rat spinal cord following SCI.	Curcumin	42-50	toll-like receptor 4	Rattus norvegicus	61-81
24621048-2	2015	This study was designed to detect whether curcumin modulates toll-like receptor 4 (TLR4) and the nuclear factor-kappa B (NF-kappaB) inflammatory signaling pathway in the injured rat spinal cord following SCI.	Curcumin	42-50	toll-like receptor 4	Rattus norvegicus	83-87
24621048-7	2015	Treatment with curcumin following SCI markedly down-regulated the levels of these agents related to the TLR4/NF-kappaB inflammatory signaling pathway.	Curcumin	15-23	toll-like receptor 4	Rattus norvegicus	104-108
24621048-9	2015	CONCLUSIONS: Post-SCI curcumin administration attenuates the TLR4/NF-kappaB inflammatory signaling pathway in the injured spinal cord, and this may be a mechanism whereby curcumin improves the outcome following SCI.	Curcumin	22-30	toll-like receptor 4	Rattus norvegicus	61-65
24621048-9	2015	CONCLUSIONS: Post-SCI curcumin administration attenuates the TLR4/NF-kappaB inflammatory signaling pathway in the injured spinal cord, and this may be a mechanism whereby curcumin improves the outcome following SCI.	Curcumin	171-179	toll-like receptor 4	Rattus norvegicus	61-65
25578635-8	2015	Pathway crosstalk analysis suggested there was a significant interaction between NSCLC and adherens junctions (or Wnt signaling pathways, which are important for cancer cell proliferation and invasion) in both 10 muM and 20 muM curcumin treated 95D cells.	Curcumin	228-236	latexin	Homo sapiens	224-227
25878600-4	2015	In addition, post-treatment with curcumin inhibited early DNA/RNA oxidation as indicated by immunocytochemistry and increased nuclear Nrf2 protein by inducing nuclear accumulation of Nrf2.	Curcumin	33-41	NFE2 like bZIP transcription factor 2	Rattus norvegicus	134-138
25878600-4	2015	In addition, post-treatment with curcumin inhibited early DNA/RNA oxidation as indicated by immunocytochemistry and increased nuclear Nrf2 protein by inducing nuclear accumulation of Nrf2.	Curcumin	33-41	NFE2 like bZIP transcription factor 2	Rattus norvegicus	183-187
25878600-5	2015	These findings suggest that curcumin activates the expression of thioredoxin, an antioxidant protein in the Nrf2 pathway, and protects neurons from death caused by oxygen-glucose deprivation in an in vitro model of ischemia/reperfusion.	Curcumin	28-36	thioredoxin 1	Rattus norvegicus	65-76
25878600-5	2015	These findings suggest that curcumin activates the expression of thioredoxin, an antioxidant protein in the Nrf2 pathway, and protects neurons from death caused by oxygen-glucose deprivation in an in vitro model of ischemia/reperfusion.	Curcumin	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	108-112
25479948-0	2015	Curcumin attenuates CFA induced thermal hyperalgesia by modulation of antioxidant enzymes and down regulation of TNF-alpha, IL-1beta and IL-6.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	113-122
25479948-0	2015	Curcumin attenuates CFA induced thermal hyperalgesia by modulation of antioxidant enzymes and down regulation of TNF-alpha, IL-1beta and IL-6.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	124-132
25479948-0	2015	Curcumin attenuates CFA induced thermal hyperalgesia by modulation of antioxidant enzymes and down regulation of TNF-alpha, IL-1beta and IL-6.	Curcumin	0-8	interleukin 6	Rattus norvegicus	137-141
25497868-3	2015	We hypothesized that curcumin and its analogues EF31 and UBS109 would disrupt angiogenesis in pancreatic cancer (PC) through modulation of HIF-1alpha and NF-kappaB.	Curcumin	21-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-149
25519685-0	2015	Curcumin ameliorate DENA-induced HCC via modulating TGF-beta, AKT, and caspase-3 expression in experimental rat model.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	52-60
25519685-0	2015	Curcumin ameliorate DENA-induced HCC via modulating TGF-beta, AKT, and caspase-3 expression in experimental rat model.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	62-65
25519685-6	2015	Curcumin treatment partially reversed DENA-induced damage as it reduced the overexpression of the angiogenic and anti-apoptotic factors TGF-beta and Akt and improved caspase-3 expression.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	136-144
25519685-6	2015	Curcumin treatment partially reversed DENA-induced damage as it reduced the overexpression of the angiogenic and anti-apoptotic factors TGF-beta and Akt and improved caspase-3 expression.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	149-152
26248429-10	2015	The data of FCM showed that curcumin could increase the expression of PTEN, GSK3beta and Caspase 3, decreased the expression of AKT.	Curcumin	28-36	AKT serine/threonine kinase 1	Homo sapiens	128-131
26248429-11	2015	CONCLUSION: The effects of curcumin on inhibiting proliferation and promoting apoptosis of EC109 cells were related with increased expression of PTEN and inhibition of PI3K/AKT signaling pathway.	Curcumin	27-35	AKT serine/threonine kinase 1	Homo sapiens	173-176
26248410-0	2015	[Effects of hydroxyl acetylated curcumin induced sonodynamic therapy on viability, apoptosis and necrosis of THP-1 macrophages].	Curcumin	32-40	GLI family zinc finger 2	Homo sapiens	109-114
26248429-0	2015	[Curcumin induces apoptosis by PTEN/PI3K/AKT pathway in EC109 cells].	Curcumin	1-9	AKT serine/threonine kinase 1	Homo sapiens	41-44
25497868-3	2015	We hypothesized that curcumin and its analogues EF31 and UBS109 would disrupt angiogenesis in pancreatic cancer (PC) through modulation of HIF-1alpha and NF-kappaB.	Curcumin	21-29	nuclear factor kappa B subunit 1	Homo sapiens	154-163
25497868-6	2015	Significant inhibition of VEGF, angiopoietin 1, angiopoietin 2, platelet derived growth factor, COX-2, and TGFbeta secretion was observed in PC cell lines treated with UBS109, EF31 or curcumin.	Curcumin	184-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	96-101
25497868-6	2015	Significant inhibition of VEGF, angiopoietin 1, angiopoietin 2, platelet derived growth factor, COX-2, and TGFbeta secretion was observed in PC cell lines treated with UBS109, EF31 or curcumin.	Curcumin	184-192	transforming growth factor beta 1	Homo sapiens	107-114
25497868-7	2015	Treatment with UBS109, EF31 or curcumin inhibited HSP90, NF-kappaB, and HIF-1alpha transcription in PC cell lines.	Curcumin	31-39	nuclear factor kappa B subunit 1	Homo sapiens	57-66
25497868-7	2015	Treatment with UBS109, EF31 or curcumin inhibited HSP90, NF-kappaB, and HIF-1alpha transcription in PC cell lines.	Curcumin	31-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-82
25497868-9	2015	Finally, we demonstrate for the first time that curcumin analogues EF31 and UBS109 induce the downregulation of HIF-1alpha, Hsp90, COX-2 and VEGF in tumor samples from xenograft models compared to untreated xenografts.	Curcumin	48-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	112-122
25497868-9	2015	Finally, we demonstrate for the first time that curcumin analogues EF31 and UBS109 induce the downregulation of HIF-1alpha, Hsp90, COX-2 and VEGF in tumor samples from xenograft models compared to untreated xenografts.	Curcumin	48-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
25497868-9	2015	Finally, we demonstrate for the first time that curcumin analogues EF31 and UBS109 induce the downregulation of HIF-1alpha, Hsp90, COX-2 and VEGF in tumor samples from xenograft models compared to untreated xenografts.	Curcumin	48-56	vascular endothelial growth factor A	Homo sapiens	141-145
25901198-1	2015	We recently described the synthesis and characterization of a novel difluorinatedbenzylidene analog of curcumin, commonly referred as CDF, which demonstrated significantly enhanced bioavailability and in vivo anticancer activity.	Curcumin	103-111	interleukin 6	Homo sapiens	134-137
25635662-0	2015	Interplay between inhibitory ferric and stimulatory curcumin regulates phosphorylation-dependent human cystic fibrosis transmembrane conductance regulator and DeltaF508 activity.	Curcumin	52-60	CF transmembrane conductance regulator	Homo sapiens	103-154
25635662-1	2015	Curcumin potentiates cystic fibrosis transmembrane conductance regulator (CFTR) activation in an ATP-independent but phosphorylation-dependent manner.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	21-72
25635662-1	2015	Curcumin potentiates cystic fibrosis transmembrane conductance regulator (CFTR) activation in an ATP-independent but phosphorylation-dependent manner.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	74-78
25635662-5	2015	Furthermore, curcumin potentiation of CFTR was significantly weakened not only by Fe(3+)-insensitive mutations at the interface between the regulatory domain and intracellular loop 3 but also by N-ethylmaleimide or EDTA pretreatment that removes Fe(3+).	Curcumin	13-21	CF transmembrane conductance regulator	Homo sapiens	38-42
25767602-0	2015	Induction of BCL2-Interacting Killer, BIK, is Mediated for Anti-Cancer Activity of Curcumin in Human Head and Neck Squamous Cell Carcinoma Cells.	Curcumin	83-91	BCL2 interacting killer	Homo sapiens	13-36
25767602-0	2015	Induction of BCL2-Interacting Killer, BIK, is Mediated for Anti-Cancer Activity of Curcumin in Human Head and Neck Squamous Cell Carcinoma Cells.	Curcumin	83-91	BCL2 interacting killer	Homo sapiens	38-41
25685909-0	2015	Curcumin and omega-3 fatty acids enhance NK cell-induced apoptosis of pancreatic cancer cells but curcumin inhibits interferon-gamma production: benefits of omega-3 with curcumin against cancer.	Curcumin	98-106	interferon gamma	Homo sapiens	116-132
25730045-11	2015	In conclusion, curcumin has antiproliferative and proapoptotic activities on A375 cells, the mechanism of which may be related to the inhibition of JAK-2/STAT-3 signaling pathway.	Curcumin	15-23	signal transducer and activator of transcription 3	Homo sapiens	154-160
25543853-1	2015	Curcumin (CUR) is a phytochemical that inhibits the xenobiotic ABC efflux transporters implicated in cancer multidrug resistance (MDR), such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 and 5 (MRP1 and MRP5).	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	144-158
25446581-9	2015	The effect of teuclatriol on the activity of NF-kappaB in LPS-stimulated human monocytic THP-1 cells was studied using infrared electrophoretic mobility shift assay (IR-EMSA) using curcumin as positive control (32microM).	Curcumin	181-189	nuclear factor kappa B subunit 1	Homo sapiens	45-54
25543853-1	2015	Curcumin (CUR) is a phytochemical that inhibits the xenobiotic ABC efflux transporters implicated in cancer multidrug resistance (MDR), such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 and 5 (MRP1 and MRP5).	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	160-164
25543853-1	2015	Curcumin (CUR) is a phytochemical that inhibits the xenobiotic ABC efflux transporters implicated in cancer multidrug resistance (MDR), such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 and 5 (MRP1 and MRP5).	Curcumin	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	167-199
25543853-1	2015	Curcumin (CUR) is a phytochemical that inhibits the xenobiotic ABC efflux transporters implicated in cancer multidrug resistance (MDR), such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 and 5 (MRP1 and MRP5).	Curcumin	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	201-205
25543853-1	2015	Curcumin (CUR) is a phytochemical that inhibits the xenobiotic ABC efflux transporters implicated in cancer multidrug resistance (MDR), such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 and 5 (MRP1 and MRP5).	Curcumin	0-8	ATP binding cassette subfamily C member 1	Homo sapiens	211-259
25543853-1	2015	Curcumin (CUR) is a phytochemical that inhibits the xenobiotic ABC efflux transporters implicated in cancer multidrug resistance (MDR), such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 and 5 (MRP1 and MRP5).	Curcumin	0-8	ATP binding cassette subfamily C member 1	Homo sapiens	261-265
25444916-0	2015	Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer.	Curcumin	0-8	tumor protein p53	Homo sapiens	46-49
25444916-8	2015	Conditional knockdown of p53 by tetracycline inducible expression system significantly abrogated curcumin-induced miR-192-5p/215 upregulation in the p53 wild-type H460, A427 and A549 cells.	Curcumin	97-105	microRNA 192	Homo sapiens	114-121
25577709-4	2015	In this context, aiming at further exploring the mechanisms of action of our newly synthesized antioxidant compounds (AK1 and AK2) in a skeletal muscle experimental setting, we initially investigated their scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and subsequently assessed their effect on the viability of C2 skeletal myoblasts in the presence of two pro-oxidants: H2O2 and curcumin (MTT assay).	Curcumin	391-399	adenylate kinase 1	Homo sapiens	118-121
25444916-8	2015	Conditional knockdown of p53 by tetracycline inducible expression system significantly abrogated curcumin-induced miR-192-5p/215 upregulation in the p53 wild-type H460, A427 and A549 cells.	Curcumin	97-105	tumor protein p53	Homo sapiens	149-152
25444916-7	2015	Curcumin also promoted miR-192-5p/215 expressions in A549 cells (p53 wild type) but not in H1299 cells (p53-null).	Curcumin	0-8	microRNA 192	Homo sapiens	23-30
25444916-9	2015	Conversely, ectopic expression of exogenous wild-type but not R273H mutant p53 in the p53-null H1299 cells enabled miR-192-5p/215 response to curcumin treatment.	Curcumin	142-150	tumor protein p53	Homo sapiens	75-78
25444916-9	2015	Conversely, ectopic expression of exogenous wild-type but not R273H mutant p53 in the p53-null H1299 cells enabled miR-192-5p/215 response to curcumin treatment.	Curcumin	142-150	tumor protein p53	Homo sapiens	86-89
25444916-7	2015	Curcumin also promoted miR-192-5p/215 expressions in A549 cells (p53 wild type) but not in H1299 cells (p53-null).	Curcumin	0-8	tumor protein p53	Homo sapiens	65-68
25444916-9	2015	Conversely, ectopic expression of exogenous wild-type but not R273H mutant p53 in the p53-null H1299 cells enabled miR-192-5p/215 response to curcumin treatment.	Curcumin	142-150	microRNA 192	Homo sapiens	115-122
25444916-10	2015	The proapoptotic effects of curcumin also depended on miR-192-5p/215 induction, and antagonizing miR-192-5p/215 expression attenuated curcumin-induced apoptosis in H460, A427 and A549 cells, but not in H1299 cells.	Curcumin	28-36	microRNA 192	Homo sapiens	54-61
25444916-8	2015	Conditional knockdown of p53 by tetracycline inducible expression system significantly abrogated curcumin-induced miR-192-5p/215 upregulation in the p53 wild-type H460, A427 and A549 cells.	Curcumin	97-105	tumor protein p53	Homo sapiens	25-28
25444916-10	2015	The proapoptotic effects of curcumin also depended on miR-192-5p/215 induction, and antagonizing miR-192-5p/215 expression attenuated curcumin-induced apoptosis in H460, A427 and A549 cells, but not in H1299 cells.	Curcumin	134-142	microRNA 192	Homo sapiens	97-104
25444916-12	2015	Taken together, this study highlights that the proapoptotic effects of curcumin depend on miR-192-5p/215 induction and the p53-miR-192-5p/215-XIAP pathway is an important therapeutic target for non-small cell lung cancer.	Curcumin	71-79	microRNA 192	Homo sapiens	90-97
25474544-5	2015	Curcumin increased the expression of glucose transporter 2 (GLUT2) and phosphorylation of insulin receptor (IR), insulin receptor substrate-1 (IRS1), phosphatidylinositol-3-kinase (PI3K) and AKT in the INS-1 cells.	Curcumin	0-8	insulin receptor substrate 1	Rattus norvegicus	113-141
25444916-12	2015	Taken together, this study highlights that the proapoptotic effects of curcumin depend on miR-192-5p/215 induction and the p53-miR-192-5p/215-XIAP pathway is an important therapeutic target for non-small cell lung cancer.	Curcumin	71-79	tumor protein p53	Homo sapiens	123-126
25446255-5	2015	Immunofluorescence studies showed that VIP increases translocation of the p50 subunit of NF-kappaB1 to the nucleus, an effect that was inhibited by curcumin.	Curcumin	148-156	vasoactive intestinal peptide	Homo sapiens	39-42
25446255-5	2015	Immunofluorescence studies showed that VIP increases translocation of the p50 subunit of NF-kappaB1 to the nucleus, an effect that was inhibited by curcumin.	Curcumin	148-156	nuclear factor kappa B subunit 1	Homo sapiens	74-77
25446255-9	2015	Curcumin blocks the activating effect of VIP on COX-2 promoter/prostaglandin E2 (PGE2) production and VEGF expression and secretion.	Curcumin	0-8	vasoactive intestinal peptide	Homo sapiens	41-44
25446255-9	2015	Curcumin blocks the activating effect of VIP on COX-2 promoter/prostaglandin E2 (PGE2) production and VEGF expression and secretion.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	48-53
25446255-9	2015	Curcumin blocks the activating effect of VIP on COX-2 promoter/prostaglandin E2 (PGE2) production and VEGF expression and secretion.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	102-106
25283245-7	2015	Curcumin (GSTM1 inhibitor), BSO (glutathione synthesis inhibitor), and MK571 (MRP1 inhibitor) considerably reversed the acquired resistance to VCR and VDS, but not to VRB.	Curcumin	0-8	glutathione S-transferase mu 1	Homo sapiens	10-15
24155070-8	2015	Five highly connected regions in PPI networks were detected by MCODE algorithm, suggesting anti-aging effect of curcumin may be underlined through five different pathways including Notch signaling pathway, basal transcription factors, cell cycle regulation, ribosome, Wnt signaling pathway, and p53 pathway.	Curcumin	112-120	p53	Drosophila melanogaster	295-298
25574201-12	2015	The serum level of E-selectin and the expression levels of TSP-1 and TGF-beta1 significantly increased in the sepsis rats when compared with the control group rats; however, the levels decreased significantly following treatment with curcumin (10 or 20 mg/kg).	Curcumin	234-242	transforming growth factor, beta 1	Rattus norvegicus	69-78
25499851-10	2015	Therefore, we suggest that ABT-199 or curcumin may be potentially useful to improve tumor regression and chemotherapeutic response in patients with MnSOD/Bcl-2-positive tumors.	Curcumin	38-46	BCL2 apoptosis regulator	Homo sapiens	154-159
25444713-8	2015	The beneficial actions of curcumin are closely associated with its ability to increase Nrf2 expression and inhibit NF-kappaB activation.	Curcumin	26-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	87-91
25474544-5	2015	Curcumin increased the expression of glucose transporter 2 (GLUT2) and phosphorylation of insulin receptor (IR), insulin receptor substrate-1 (IRS1), phosphatidylinositol-3-kinase (PI3K) and AKT in the INS-1 cells.	Curcumin	0-8	insulin receptor substrate 1	Rattus norvegicus	143-147
25474544-5	2015	Curcumin increased the expression of glucose transporter 2 (GLUT2) and phosphorylation of insulin receptor (IR), insulin receptor substrate-1 (IRS1), phosphatidylinositol-3-kinase (PI3K) and AKT in the INS-1 cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	191-194
25474544-6	2015	Moreover, curcumin stimulation increased the expression of PDX-1 and GCK.	Curcumin	10-18	pancreatic and duodenal homeobox 1	Rattus norvegicus	59-64
25474544-7	2015	This investigation suggests that curcumin prevented high glucose-reduced insulin expression and secretion through activation of the PI3K/Akt/GLUT2 pathway in INS-1 cells.	Curcumin	33-41	AKT serine/threonine kinase 1	Rattus norvegicus	137-140
26415414-7	2015	CONCLUSION: Curcumin can decrease cerebral ischemia reperfusion pathological damage significantly and suppressed the expression of MMP-9 and TNF-alpha, and Evans blue dye, brain tissue damage, leukocyte infiltration, which may be involved in protective mechanisms of curcumin.	Curcumin	12-20	tumor necrosis factor	Rattus norvegicus	141-150
25454972-8	2015	Immunohistochemistry for CD31 revealed well-formed blood vessels with increased microvessel density on days 3, 7, and 14 in the curcumin-treated group.	Curcumin	128-136	platelet and endothelial cell adhesion molecule 1	Rattus norvegicus	25-29
25230992-0	2015	Tumour growth inhibition and anti-angiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition.	Curcumin	59-67	phosphodiesterase 4A	Homo sapiens	100-104
25230992-8	2015	In vitro, curcumin inhibited basal and VEGF-stimulated HUVEC proliferation and migration and delayed cell cycle progression at G0/G1, similarly to the combination of selective PDE2 and PDE4 inhibitors.	Curcumin	10-18	vascular endothelial growth factor A	Homo sapiens	39-43
25230992-8	2015	In vitro, curcumin inhibited basal and VEGF-stimulated HUVEC proliferation and migration and delayed cell cycle progression at G0/G1, similarly to the combination of selective PDE2 and PDE4 inhibitors.	Curcumin	10-18	phosphodiesterase 4A	Homo sapiens	185-189
25230992-10	2015	Moreover, curcumin was able to inhibit VEGF-induced cAMP-PDE activity without acting on cGMP-PDE activity and to modulate PDE2 and PDE4 expressions in HUVECs.	Curcumin	10-18	vascular endothelial growth factor A	Homo sapiens	39-43
25230992-10	2015	Moreover, curcumin was able to inhibit VEGF-induced cAMP-PDE activity without acting on cGMP-PDE activity and to modulate PDE2 and PDE4 expressions in HUVECs.	Curcumin	10-18	phosphodiesterase 4A	Homo sapiens	131-135
25230992-11	2015	The present results suggest that curcumin exerts its in vitro anti-angiogenic and in vivo anti-tumour properties through combined PDE2 and PDE4 inhibition.	Curcumin	33-41	phosphodiesterase 4A	Homo sapiens	139-143
25359171-4	2015	Interestingly, separate as well as combined supplementation of curcumin (60 mg/kg body weight) and quercetin (40 mg/kg body weight) to BP-treated animals resulted in a significant decrease in the protein expression of Bcl-2 but caused a significant increase in the protein expression of Bax along with a noticeable improvement in the number of apoptotic cells.	Curcumin	63-71	B cell leukemia/lymphoma 2	Mus musculus	218-223
25277658-0	2015	GRP78 mediates the therapeutic efficacy of curcumin on colon cancer.	Curcumin	43-51	heat shock protein family A (Hsp70) member 5	Homo sapiens	0-5
25277658-3	2015	However, the role of GRP78 in the cytotoxic effect of curcumin on colon cancer cells is still unclear.	Curcumin	54-62	heat shock protein family A (Hsp70) member 5	Homo sapiens	21-26
25277658-8	2015	GRP78KD cells showed more resistance to curcumin treatment compared with scrambled control cells.	Curcumin	40-48	heat shock protein family A (Hsp70) member 5	Homo sapiens	0-5
25277658-9	2015	Overexpressed GRP78 in HT-29 cells increased the sensitivity to curcumin treatment.	Curcumin	64-72	heat shock protein family A (Hsp70) member 5	Homo sapiens	14-19
25277658-10	2015	According to the cell cycle analysis and TUNEL assay, we found that apoptosis dramatically increased in scrambled control cells compared to GRP78KD DLD-1 cells after curcumin treatment.	Curcumin	166-174	heat shock protein family A (Hsp70) member 5	Homo sapiens	140-145
25277658-11	2015	Finally, we evaluated levels of Bcl-2, BAX, and Bad and found that an increase of Bcl-2 level was observed in GRP78KD cells treated with curcumin.	Curcumin	137-145	BCL2 apoptosis regulator	Homo sapiens	32-37
25277658-11	2015	Finally, we evaluated levels of Bcl-2, BAX, and Bad and found that an increase of Bcl-2 level was observed in GRP78KD cells treated with curcumin.	Curcumin	137-145	BCL2 associated X, apoptosis regulator	Homo sapiens	39-42
25277658-11	2015	Finally, we evaluated levels of Bcl-2, BAX, and Bad and found that an increase of Bcl-2 level was observed in GRP78KD cells treated with curcumin.	Curcumin	137-145	BCL2 apoptosis regulator	Homo sapiens	82-87
25277658-11	2015	Finally, we evaluated levels of Bcl-2, BAX, and Bad and found that an increase of Bcl-2 level was observed in GRP78KD cells treated with curcumin.	Curcumin	137-145	heat shock protein family A (Hsp70) member 5	Homo sapiens	110-115
25277658-12	2015	Those results were consistent with the increasing of resistance to curcumin after silencing of GRP78.	Curcumin	67-75	heat shock protein family A (Hsp70) member 5	Homo sapiens	95-100
25277658-13	2015	The levels of GRP78 expression might determine the therapeutic efficacy of curcumin against colon cancer cells.	Curcumin	75-83	heat shock protein family A (Hsp70) member 5	Homo sapiens	14-19
25594233-2	2015	This study aimed at identifying whether curcumin, demethoxycurcumin, and bisdemethoxycurcumin could modulate efflux function of human P-glycoprotein and be used as chemosensitizers in cancer treatments.	Curcumin	40-48	ATP binding cassette subfamily B member 1	Homo sapiens	134-148
25558927-2	2015	This paper reports a facile route to develop human serum albumin (HSA)-curcumin (CCM) nanoparticles, in which beta-mercaptoethanol (beta-ME) acted as an inducer and CCM acted as a bridge.	Curcumin	81-84	albumin	Homo sapiens	51-79
25558927-2	2015	This paper reports a facile route to develop human serum albumin (HSA)-curcumin (CCM) nanoparticles, in which beta-mercaptoethanol (beta-ME) acted as an inducer and CCM acted as a bridge.	Curcumin	165-168	albumin	Homo sapiens	51-79
25447314-11	2015	Instead, myofibroblasts expressed higher levels of heat shock protein (HSP)72 compared to fibroblasts in response to curcumin, suggesting that TGF-beta1 treatment alters the stress-responses of the cells.	Curcumin	117-125	heat shock protein family A (Hsp70) member 1A	Homo sapiens	71-77
25493575-9	2015	Simultaneous delivery of the AID peptide with curcumin allowed for effective attenuation of the L-type Ca(2+) channel-activated increases in superoxide (assessed as changes in DHE fluorescence; Empty NP = 53.1 +- 7.6%; NP-C-AID = 7.32 +- 3.57%) and mitochondrial membrane potential (assessed as changes in JC-1 fluorescence; Empty NP = 19.8 +- 2.8%; NP-C-AID=13.05 +- 1.78%).	Curcumin	46-54	activation-induced cytidine deaminase	Rattus norvegicus	29-32
25493575-9	2015	Simultaneous delivery of the AID peptide with curcumin allowed for effective attenuation of the L-type Ca(2+) channel-activated increases in superoxide (assessed as changes in DHE fluorescence; Empty NP = 53.1 +- 7.6%; NP-C-AID = 7.32 +- 3.57%) and mitochondrial membrane potential (assessed as changes in JC-1 fluorescence; Empty NP = 19.8 +- 2.8%; NP-C-AID=13.05 +- 1.78%).	Curcumin	46-54	activation-induced cytidine deaminase	Rattus norvegicus	224-227
25493575-9	2015	Simultaneous delivery of the AID peptide with curcumin allowed for effective attenuation of the L-type Ca(2+) channel-activated increases in superoxide (assessed as changes in DHE fluorescence; Empty NP = 53.1 +- 7.6%; NP-C-AID = 7.32 +- 3.57%) and mitochondrial membrane potential (assessed as changes in JC-1 fluorescence; Empty NP = 19.8 +- 2.8%; NP-C-AID=13.05 +- 1.78%).	Curcumin	46-54	activation-induced cytidine deaminase	Rattus norvegicus	224-227
25447314-11	2015	Instead, myofibroblasts expressed higher levels of heat shock protein (HSP)72 compared to fibroblasts in response to curcumin, suggesting that TGF-beta1 treatment alters the stress-responses of the cells.	Curcumin	117-125	transforming growth factor beta 1	Homo sapiens	143-152
25580684-1	2015	In this study a series of curcumin analogues were evaluated for their ability to inhibit the activation of NF-kappaBeta, a transcription factor at the crossroads of cancer-inflammation.	Curcumin	26-34	nuclear factor kappa B subunit 1	Homo sapiens	107-119
25286751-3	2015	LLL12, a curcumin derivative, inhibits STAT3 functions, thereby reduces growth of GBM.	Curcumin	9-17	signal transducer and activator of transcription 3	Homo sapiens	39-44
25445048-1	2015	Curcumin exerts an inhibitory effect on hepatic stellate cell (HSC) activation, a key step for liver fibrogenesis, and on liver fibrosis by up-regulation of peroxisome proliferator-activated receptor-gamma (PPARgamma) expression.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	157-205
25445048-1	2015	Curcumin exerts an inhibitory effect on hepatic stellate cell (HSC) activation, a key step for liver fibrogenesis, and on liver fibrosis by up-regulation of peroxisome proliferator-activated receptor-gamma (PPARgamma) expression.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	207-216
25445048-4	2015	Therefore, researches on the effect of curcumin on PGC-1alpha might contribute to understanding of the mechanisms underlying curcumin inhibition of HSC activation and liver fibrosis through PPARgamma.	Curcumin	39-47	PPARG coactivator 1 alpha	Homo sapiens	51-61
25445048-4	2015	Therefore, researches on the effect of curcumin on PGC-1alpha might contribute to understanding of the mechanisms underlying curcumin inhibition of HSC activation and liver fibrosis through PPARgamma.	Curcumin	39-47	peroxisome proliferator activated receptor gamma	Homo sapiens	190-199
25445048-4	2015	Therefore, researches on the effect of curcumin on PGC-1alpha might contribute to understanding of the mechanisms underlying curcumin inhibition of HSC activation and liver fibrosis through PPARgamma.	Curcumin	125-133	PPARG coactivator 1 alpha	Homo sapiens	51-61
25445048-4	2015	Therefore, researches on the effect of curcumin on PGC-1alpha might contribute to understanding of the mechanisms underlying curcumin inhibition of HSC activation and liver fibrosis through PPARgamma.	Curcumin	125-133	peroxisome proliferator activated receptor gamma	Homo sapiens	190-199
25445048-5	2015	The present study aimed to investigate the effect of curcumin on PGC-1alpha expression in HSCs in vitro and examine the underlying molecular mechanisms by western blot, reat-time PCR, and transfection.	Curcumin	53-61	PPARG coactivator 1 alpha	Homo sapiens	65-75
25445048-6	2015	Our results showed that curcumin stimulation increased PGC-1alpha expression and the effects of curcumin on PGC-1alpha expression were correlated with the activation of adenosine monophosphate-activated protein kinase (AMPK).	Curcumin	24-32	PPARG coactivator 1 alpha	Homo sapiens	55-65
25445048-6	2015	Our results showed that curcumin stimulation increased PGC-1alpha expression and the effects of curcumin on PGC-1alpha expression were correlated with the activation of adenosine monophosphate-activated protein kinase (AMPK).	Curcumin	96-104	PPARG coactivator 1 alpha	Homo sapiens	108-118
25445048-7	2015	Curcumin increased superoxide dimutase-2 (SOD2) transcription and activity by AMPK/PGC-1alpha axis.	Curcumin	0-8	PPARG coactivator 1 alpha	Homo sapiens	83-93
25445048-9	2015	These results demonstrated the promotion effect of curcumin on PGC-1alpha expression through AMPK pathway, which led to the increases in PPARgamma activity and in SOD-2 transcription and activity.	Curcumin	51-59	PPARG coactivator 1 alpha	Homo sapiens	63-73
25445048-9	2015	These results demonstrated the promotion effect of curcumin on PGC-1alpha expression through AMPK pathway, which led to the increases in PPARgamma activity and in SOD-2 transcription and activity.	Curcumin	51-59	peroxisome proliferator activated receptor gamma	Homo sapiens	137-146
25497288-0	2015	Novel curcumin analogue 14p protects against myocardial ischemia reperfusion injury through Nrf2-activating anti-oxidative activity.	Curcumin	6-14	NFE2 like bZIP transcription factor 2	Rattus norvegicus	92-96
25497288-12	2015	CONCLUSION: These data support the novel curcumin analogue 14p as a promising antioxidant to decrease oxidative stress and limit myocardial ischemia reperfusion injury via activating Nrf2.	Curcumin	41-49	NFE2 like bZIP transcription factor 2	Rattus norvegicus	183-187
25445044-2	2015	This study tested the hypothesis that attenuation of maladaptive cardiac repair with curcumin is associated with a dual ACE-inhibition and angiotensin II AT1 receptor antagonism after myocardial infarction.	Curcumin	85-93	angiotensin I converting enzyme	Rattus norvegicus	120-123
25445044-5	2015	Relative to the control animals, dietary treatment with curcumin significantly reduced levels of ACE and AT1 receptor protein as determined by Western blot assay, coincident with less locally-expressed ACE and AT1 receptor in myocardium and coronary vessels as identified by immunohistochemistry.	Curcumin	56-64	angiotensin I converting enzyme	Rattus norvegicus	97-100
25445044-5	2015	Relative to the control animals, dietary treatment with curcumin significantly reduced levels of ACE and AT1 receptor protein as determined by Western blot assay, coincident with less locally-expressed ACE and AT1 receptor in myocardium and coronary vessels as identified by immunohistochemistry.	Curcumin	56-64	angiotensin I converting enzyme	Rattus norvegicus	202-205
25445044-11	2015	These results suggest that curcumin attenuates maladaptive cardiac repair and enhances cardiac function, primarily mediated by a dual ACE-inhibition and AT1 receptor antagonism after myocardial infarction.	Curcumin	27-35	angiotensin I converting enzyme	Rattus norvegicus	134-137
25445048-0	2015	Curcumin regulates peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression by AMPK pathway in hepatic stellate cells in vitro.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	19-67
25446495-0	2015	A combined molecular docking and charge density analysis is a new approach for medicinal research to understand drug-receptor interaction: curcumin-AChE model.	Curcumin	139-147	acetylcholinesterase (Cartwright blood group)	Homo sapiens	148-152
25446495-1	2015	In the present study, a molecular docking analysis has been performed on diketone form of curcumin molecule with acetylcholinesterase (AChE).	Curcumin	90-98	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-133
25446495-1	2015	In the present study, a molecular docking analysis has been performed on diketone form of curcumin molecule with acetylcholinesterase (AChE).	Curcumin	90-98	acetylcholinesterase (Cartwright blood group)	Homo sapiens	135-139
25446495-2	2015	The calculated lowest docked energy of curcumin molecule in the active site of AChE is -11.21 kcal/mol; this high negative value indicates that the molecule exhibits large binding affinity towards AChE.	Curcumin	39-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-83
25446495-2	2015	The calculated lowest docked energy of curcumin molecule in the active site of AChE is -11.21 kcal/mol; this high negative value indicates that the molecule exhibits large binding affinity towards AChE.	Curcumin	39-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	197-201
25446495-3	2015	When the curcumin molecule present in the active site of AChE, subsequently, its conformation has altered significantly and the molecule adopts a U-shape geometry as it is linear in gas phase (before entering into the active site).	Curcumin	9-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-61
25229889-5	2015	Furthermore, the phosphorylation of mitochondrial HKII through AKT was responsible for the curcumin-induced dissociation of HKII, which was different from the mechanism of HKII inhibitor 3-BrPA.	Curcumin	91-99	AKT serine/threonine kinase 1	Homo sapiens	63-66
25991545-11	2015	Tc-99m-HYNIC-VEGF-c-SPECT imaging showed decreased uptake to the tumor, which may indicate a lower expression of VEGFR2/3 in curcumin treated tumors; however, a statistically significant difference was not achieved (p&gt;0.05).	Curcumin	125-133	vascular endothelial growth factor C	Homo sapiens	13-19
25991545-12	2015	Additionally, curcumin treatment showed a significantly low level of expression of pro-angiogenic factors (p&lt;0.05) and a decrease in micro-vessel density (vWF) in animals compared with that of vehicle treated tumors.	Curcumin	14-22	von Willebrand factor	Homo sapiens	158-161
25446996-4	2015	Curcumin also showed inhibitory effect on the elevation of pro-inflammatory cytokines and translocation of NFkappaB into the nucleus and promoted the activation of the transcription factor Nrf-2 to provide protection against oxidants.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	189-194
25550533-0	2015	Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFkappaB signaling.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	100-105
25550533-0	2015	Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NFkappaB signaling.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	106-114
25550533-5	2015	MATERIALS AND METHODS: To suppress the CSC phenotype, two breast cancer cell lines (MDA-MB-231 cells and MCF7 cells transfected with HER2) were treated with curcumin (10 muM) with or without EGCG (10 muM) for 48 h. We used tumor-sphere formation and wound-healing assays to determine CSC phenotype.	Curcumin	157-165	erb-b2 receptor tyrosine kinase 2	Homo sapiens	133-137
25550533-9	2015	Western blot and immunoprecipitation analyses revealed that curcumin and EGCG specifically inhibited STAT3 phosphorylation and STAT3-NFkB interaction was retained.	Curcumin	60-68	signal transducer and activator of transcription 3	Homo sapiens	101-106
25550533-9	2015	Western blot and immunoprecipitation analyses revealed that curcumin and EGCG specifically inhibited STAT3 phosphorylation and STAT3-NFkB interaction was retained.	Curcumin	60-68	signal transducer and activator of transcription 3	Homo sapiens	127-132
25854367-1	2015	OBJECTIVE: To investigate the regulatory effect of curcumin on expression of signal transducer and activator of transcription 3 (STAT3) in skin squamous cell carcinoma tissues as well as possible mechanisms of curcumin in prevention and treatment of skin squamous cell carcinoma.	Curcumin	51-59	signal transducer and activator of transcription 3	Homo sapiens	77-127
25854367-1	2015	OBJECTIVE: To investigate the regulatory effect of curcumin on expression of signal transducer and activator of transcription 3 (STAT3) in skin squamous cell carcinoma tissues as well as possible mechanisms of curcumin in prevention and treatment of skin squamous cell carcinoma.	Curcumin	51-59	signal transducer and activator of transcription 3	Homo sapiens	129-134
25854367-4	2015	The effects of 5,10 and 15 umol/L curcumin on expression levels of STAT3 were determined by Western blotting and on transcription levels of STAT3 mRNA by RT-PCR.	Curcumin	34-42	signal transducer and activator of transcription 3	Homo sapiens	67-72
25854367-7	2015	Curcumin showed significant dose-dependent inhibitory effects on the transcription level of STAT3 mRNA (p&lt;0.05).	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	92-97
25854367-8	2015	CONCLUSIONS: Curcumin may reduce the invasive ability of A431 cells by inhibiting the activation of STAT3 signal pathway and expression of STAT3 as a target gene in the pathway.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	100-105
25854367-8	2015	CONCLUSIONS: Curcumin may reduce the invasive ability of A431 cells by inhibiting the activation of STAT3 signal pathway and expression of STAT3 as a target gene in the pathway.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	139-144
25890744-0	2015	Anti-inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-1beta transgenic mice subjected to the lipopolysaccharide-induced sepsis.	Curcumin	30-38	interleukin 1 beta	Mus musculus	75-83
25517601-5	2015	We observed that curcumin cell death induction was heterogeneous, of note 16 HMCLs were highly sensitive to curcumin (LD50 &lt; 20.5 muM), 6 HMCLs exhibited intermediate LD50 values (20.5 muM &lt;= LD50 &lt; 32.2 muM) and only 7 HMCLs were weakly sensitive (35 &lt; LD50 &lt; 56 muM).	Curcumin	17-25	latexin	Homo sapiens	188-191
25517601-5	2015	We observed that curcumin cell death induction was heterogeneous, of note 16 HMCLs were highly sensitive to curcumin (LD50 &lt; 20.5 muM), 6 HMCLs exhibited intermediate LD50 values (20.5 muM &lt;= LD50 &lt; 32.2 muM) and only 7 HMCLs were weakly sensitive (35 &lt; LD50 &lt; 56 muM).	Curcumin	17-25	latexin	Homo sapiens	188-191
25517601-5	2015	We observed that curcumin cell death induction was heterogeneous, of note 16 HMCLs were highly sensitive to curcumin (LD50 &lt; 20.5 muM), 6 HMCLs exhibited intermediate LD50 values (20.5 muM &lt;= LD50 &lt; 32.2 muM) and only 7 HMCLs were weakly sensitive (35 &lt; LD50 &lt; 56 muM).	Curcumin	17-25	latexin	Homo sapiens	188-191
25517601-5	2015	We observed that curcumin cell death induction was heterogeneous, of note 16 HMCLs were highly sensitive to curcumin (LD50 &lt; 20.5 muM), 6 HMCLs exhibited intermediate LD50 values (20.5 muM &lt;= LD50 &lt; 32.2 muM) and only 7 HMCLs were weakly sensitive (35 &lt; LD50 &lt; 56 muM).	Curcumin	108-116	latexin	Homo sapiens	133-136
25517601-9	2015	We also unravel the contribution of anti-apoptotic Bcl-2 family molecules in curcumin response.	Curcumin	77-85	BCL2 apoptosis regulator	Homo sapiens	51-56
25792385-11	2015	Furthermore, we observed that curcumin increased DUSP-2 protein expression and decreased the phosphorylation of ERK and JNK.	Curcumin	30-38	mitogen-activated protein kinase 1	Homo sapiens	112-115
25613752-0	2015	Curcumin treatment suppresses CCR7 expression and the differentiation and migration of human circulating fibrocytes.	Curcumin	0-8	C-C motif chemokine receptor 7	Homo sapiens	30-34
25792385-11	2015	Furthermore, we observed that curcumin increased DUSP-2 protein expression and decreased the phosphorylation of ERK and JNK.	Curcumin	30-38	mitogen-activated protein kinase 8	Homo sapiens	120-123
25613752-9	2015	RESULTS: Curcumin treatment (72 h; 20 muM) significantly decreased the expression of COL I, alpha-SMA and CCR7, as well as TGF-betal secretion, in human circulating fibrocytes.	Curcumin	9-17	C-C motif chemokine receptor 7	Homo sapiens	106-110
25613752-10	2015	The inhibitory effect of curcumin on the differentiation and migration of human circulating fibrocytes is likely via regulating the CCR7/CCL21 signaling pathway, in particular by reducing CCR7 expression.	Curcumin	25-33	C-C motif chemokine receptor 7	Homo sapiens	132-136
25792385-12	2015	CONCLUSION: Our results suggest that low-dose curcumin may enhance the radiosensitivity of human glioma U87 cells in vitro by inducing G2/M cell cycle arrest through up-regulation of DUSP-2 expression and inhibition of ERK and JNK phosphorylation.	Curcumin	46-54	mitogen-activated protein kinase 1	Homo sapiens	219-222
25613752-10	2015	The inhibitory effect of curcumin on the differentiation and migration of human circulating fibrocytes is likely via regulating the CCR7/CCL21 signaling pathway, in particular by reducing CCR7 expression.	Curcumin	25-33	C-C motif chemokine receptor 7	Homo sapiens	188-192
25792385-12	2015	CONCLUSION: Our results suggest that low-dose curcumin may enhance the radiosensitivity of human glioma U87 cells in vitro by inducing G2/M cell cycle arrest through up-regulation of DUSP-2 expression and inhibition of ERK and JNK phosphorylation.	Curcumin	46-54	mitogen-activated protein kinase 8	Homo sapiens	227-230
25772169-3	2015	The molecular mechanisms underlying the targets of curcumin are diverse and involve combinations of multiple signaling pathways, including NF-kappaB and STAT3 signaling.	Curcumin	51-59	signal transducer and activator of transcription 3	Homo sapiens	153-158
25998190-9	2015	RESULTS: Curcumin dose-dependently inhibited M1 macrophage polarization and the production of TNF-alpha, IL-6, and IL-12B (p40).	Curcumin	9-17	tumor necrosis factor	Homo sapiens	94-103
25998190-9	2015	RESULTS: Curcumin dose-dependently inhibited M1 macrophage polarization and the production of TNF-alpha, IL-6, and IL-12B (p40).	Curcumin	9-17	interleukin 6	Homo sapiens	105-109
25998190-11	2015	Furthermore, curcumin significantly inhibited the phosphorylation of ERK, JNK, p38, and nuclear factor (NF)-kappaB.	Curcumin	13-21	mitogen-activated protein kinase 8	Homo sapiens	74-77
25998190-11	2015	Furthermore, curcumin significantly inhibited the phosphorylation of ERK, JNK, p38, and nuclear factor (NF)-kappaB.	Curcumin	13-21	mitogen-activated protein kinase 14	Homo sapiens	79-82
25998190-11	2015	Furthermore, curcumin significantly inhibited the phosphorylation of ERK, JNK, p38, and nuclear factor (NF)-kappaB.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	88-114
25998190-12	2015	In contrast, SiTLR4 in combination with p-JNK, p-ERK, and p-p38 inhibition reduced the effect of curcumin on polarization.	Curcumin	97-105	mitogen-activated protein kinase 8	Homo sapiens	42-45
25998190-12	2015	In contrast, SiTLR4 in combination with p-JNK, p-ERK, and p-p38 inhibition reduced the effect of curcumin on polarization.	Curcumin	97-105	mitogen-activated protein kinase 14	Homo sapiens	60-63
26862311-8	2015	RESULTS: Administration of low doses of curcumin (0.1 and 1 microg/ml) could decrease Th17 percentages (p = 0.000 and p = 0.000 compared to control), reduce IL-17A productions (p = 0.000 and p = 0.000 compared to control), increase Treg percentages (p = 0.001 and p = 0.000 compared to control), and increase TGF-beta1 productions (p = 0.001 and p = 0.000 compared to control) on CD4+ T cells of SLE patients.	Curcumin	40-48	transforming growth factor beta 1	Homo sapiens	309-318
25523883-5	2015	Higher baseline plasma endothelin-1 (rs=-0.587; p&lt;0.01) and leptin (rs=-0.470; p&lt;0.05) in curcumin-treated individuals was associated with greater reductions in IDS-SR30 score after 8 weeks of treatment.	Curcumin	96-104	endothelin 1	Homo sapiens	23-35
25523883-4	2015	Compared to placebo, 8 weeks of curcumin supplementation was associated with elevations in urinary thromboxane B2 (p&lt;0.05), and substance P (p&lt;0.001); while placebo supplementation was associated with reductions in aldosterone (p&lt;0.05) and cortisol (p&lt;0.05).	Curcumin	32-40	tachykinin precursor 1	Homo sapiens	131-142
26170881-8	2015	In conclusion, our results show that AKAP79-anchored PKA facilitated the signal relay from AMPA receptor to AKT and ERK cascades, which may be crucial for curcumin-mediated antiexcitotoxicity.	Curcumin	155-163	AKT serine/threonine kinase 1	Homo sapiens	108-111
26170881-8	2015	In conclusion, our results show that AKAP79-anchored PKA facilitated the signal relay from AMPA receptor to AKT and ERK cascades, which may be crucial for curcumin-mediated antiexcitotoxicity.	Curcumin	155-163	mitogen-activated protein kinase 1	Homo sapiens	116-119
26333125-0	2015	Curcumin-Mediated Reversal of p15 Gene Promoter Methylation: Implication in Anti-Neoplastic Action against Acute Lymphoid Leukaemia Cell Line.	Curcumin	0-8	cyclin dependent kinase inhibitor 2B	Homo sapiens	30-33
26333125-2	2015	In this study, we evaluated the potential of curcumin to reverse promoter methylation of the p15 gene in Raji cells and its ability to induce apoptosis and genomic instability.	Curcumin	45-53	cyclin dependent kinase inhibitor 2B	Homo sapiens	93-96
26333125-6	2015	The treatment of Raji cell line with 10 muM curcumin caused hypomethylation of the p15 promoter after six days.	Curcumin	44-52	latexin	Homo sapiens	40-43
26333125-6	2015	The treatment of Raji cell line with 10 muM curcumin caused hypomethylation of the p15 promoter after six days.	Curcumin	44-52	cyclin dependent kinase inhibitor 2B	Homo sapiens	83-86
26333125-7	2015	Hypomethylation of p15 was further found to be favoured by downregulation of DNA methyltransferase 1 after 10 muM curcumin treatment for six days.	Curcumin	114-122	cyclin dependent kinase inhibitor 2B	Homo sapiens	19-22
26333125-7	2015	Hypomethylation of p15 was further found to be favoured by downregulation of DNA methyltransferase 1 after 10 muM curcumin treatment for six days.	Curcumin	114-122	latexin	Homo sapiens	110-113
26333125-10	2015	Reverse-transcription PCR demonstrated that treatment with curcumin (10 muM) for six days led to the up-regulation of p15 and down-regulation of DNA methyltransferase 1.	Curcumin	59-67	latexin	Homo sapiens	72-75
26333125-10	2015	Reverse-transcription PCR demonstrated that treatment with curcumin (10 muM) for six days led to the up-regulation of p15 and down-regulation of DNA methyltransferase 1.	Curcumin	59-67	cyclin dependent kinase inhibitor 2B	Homo sapiens	118-121
26333125-11	2015	Furthermore, curcumin- mediated reversal of p15 promoter methylation might be potentiated by down-regulation of DNA methyltransferase 1 expression, which was supported by cell cycle analysis.	Curcumin	13-21	cyclin dependent kinase inhibitor 2B	Homo sapiens	44-47
25526714-3	2015	Curcumin (diferuloylmethane), a major component of turmeric, exhibits protection against LPS-induced acute lung injury (ALI).	Curcumin	0-8	toll-like receptor 4	Mus musculus	89-92
26216111-9	2015	One potential mechanism to explain several of the general health benefits associated with curcumin is that it may prevent ageing-associated changes in cellular proteins that lead to protein insolubility and aggregation after ischemia such as beta-amyloid peptide and tau protein.	Curcumin	90-98	amyloid beta precursor protein	Homo sapiens	242-262
26339812-0	2015	Curcumin ameliorates experimental autoimmune acute myocarditis in rats as evidenced by decrease in thioredoxin immunoreactivity.	Curcumin	0-8	thioredoxin 1	Rattus norvegicus	99-110
26339812-1	2015	This study was performed to investigate the effect of curcumin on cardiac myosin-induced autoimmune myocarditis in rats and the change in thioredoxin (TRX) immunoreactivity in cardiomyocytes following curcumin treatment.	Curcumin	201-209	thioredoxin 1	Rattus norvegicus	138-149
26339812-1	2015	This study was performed to investigate the effect of curcumin on cardiac myosin-induced autoimmune myocarditis in rats and the change in thioredoxin (TRX) immunoreactivity in cardiomyocytes following curcumin treatment.	Curcumin	201-209	thioredoxin 1	Rattus norvegicus	151-154
26339812-13	2015	Sections from myocarditis-curcumin group showed normal architecture with moderate immunoreactivity for TRX.	Curcumin	26-34	thioredoxin 1	Rattus norvegicus	103-106
26339812-14	2015	The present study demonstrated that curcumin ameliorates acute myocarditis in rats and encouraged the estimation of serum level of TRX as a relevant indicator for the evaluation of the progress of acute myocarditis.	Curcumin	36-44	thioredoxin 1	Rattus norvegicus	131-134
25526714-3	2015	Curcumin (diferuloylmethane), a major component of turmeric, exhibits protection against LPS-induced acute lung injury (ALI).	Curcumin	10-27	toll-like receptor 4	Mus musculus	89-92
25526714-6	2015	After 24 h of intranasal LPS instillation, a marked increase in neutrophil recruitment and myeloperoxidase (MPO) activity was noted which were significantly ameliorated in curcumin treatment group.	Curcumin	172-180	toll-like receptor 4	Mus musculus	25-28
25526714-8	2015	Inflammatory cytokine, tumour necrosis factor alpha (TNF-alpha) level was significantly attenuated by curcumin.	Curcumin	102-110	tumor necrosis factor	Mus musculus	53-62
25526714-9	2015	Hence, intranasal curcumin could be a novel therapeutic strategy for LPS-induced ALI by directly targeting the lungs and enhancing anti-oxidant levels.	Curcumin	18-26	toll-like receptor 4	Mus musculus	69-72
26053510-3	2015	This study investigates the inhibitory effects of curcumin on Abeta-induced cell damage and death involving NMDA receptor-mediated intracellular Ca(2+) elevation in human neuroblastoma SH-SY5Y cells.	Curcumin	50-58	amyloid beta precursor protein	Homo sapiens	62-67
25492214-0	2015	Ras/ERK signaling pathway is involved in curcumin-induced cell cycle arrest and apoptosis in human gastric carcinoma AGS cells.	Curcumin	41-49	mitogen-activated protein kinase 1	Homo sapiens	4-7
25492214-6	2015	Meanwhile, the activities of caspase-3, -8, and -9 were also enhanced in curcumin-treated AGS cells.	Curcumin	73-81	caspase 3	Homo sapiens	29-50
25492214-8	2015	Furthermore, downregulation of rat sarcoma (Ras) and upregulation of extracellular-signal-regulated kinase (ERK) were also observed in AGS cells treated with curcumin by Western blot.	Curcumin	158-166	Eph receptor B1	Rattus norvegicus	69-106
25492214-8	2015	Furthermore, downregulation of rat sarcoma (Ras) and upregulation of extracellular-signal-regulated kinase (ERK) were also observed in AGS cells treated with curcumin by Western blot.	Curcumin	158-166	Eph receptor B1	Rattus norvegicus	108-111
25492214-9	2015	U0126, an ERK inhibitor, blocked curcumin-induced apoptosis.	Curcumin	33-41	mitogen-activated protein kinase 1	Homo sapiens	10-13
25492214-10	2015	The results suggested that curcumin inhibited the growth of the AGS cells and induced apoptosis through the activation of Ras/ERK signaling pathway and downstream caspase cascade, and curcumin might be a potential target for the treatment of gastric carcinoma.	Curcumin	27-35	mitogen-activated protein kinase 1	Homo sapiens	126-129
26626244-0	2015	Curcumin Reduces Tumour Necrosis Factor-Enhanced Annexin V-Positive Microparticle Release in Human Vascular Endothelial Cells.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	17-39
26626244-2	2015	The aim of this study was to evaluate the effects of curcumin on microparticle release from endothelial cells undergoing TNF-induced cell activation and apoptosis.	Curcumin	53-61	tumor necrosis factor	Homo sapiens	121-124
26626244-5	2015	Curcumin attenuated microparticle release caused by TNF or TNF plus CHX treatments.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	52-55
26626244-6	2015	The pretreatment by curcumin not only negated the accelerated cell death and apoptosis caused by TNF and CHX, but also diminished TNF-induced cell activation, as assessed by reduced surface expression of intercellular adhesion molecule 1, and adhesion of monocytes to endothelial monolayers.	Curcumin	20-28	tumor necrosis factor	Homo sapiens	97-100
26626244-6	2015	The pretreatment by curcumin not only negated the accelerated cell death and apoptosis caused by TNF and CHX, but also diminished TNF-induced cell activation, as assessed by reduced surface expression of intercellular adhesion molecule 1, and adhesion of monocytes to endothelial monolayers.	Curcumin	20-28	tumor necrosis factor	Homo sapiens	130-133
26626244-7	2015	CONCLUSION: Curcumin reduced microparticle release from endothelial cells undergoing cell activation and apoptosis, which supports its protective role in TNF-associated endothelial dysfunction, and highlights its potential use as a nutraceutical agent for vascular inflammatory diseases.	Curcumin	12-20	tumor necrosis factor	Homo sapiens	154-157
26108226-0	2015	Paclitaxel-sensitization enhanced by curcumin involves down-regulation of nuclear factor-kappaB and Lin28 in Hep3B cells.	Curcumin	37-45	lin-28 homolog A	Homo sapiens	100-105
26108226-4	2015	Curcumin, a non-toxic anti-inflammatory agent, inhibits NF-kappaB activity in vitro.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	56-65
26108226-5	2015	In this study, we reported that a combination of curcumin and paclitaxel exhibited synergistic anti-proliferative and pro-apoptosis effects on Hep3B cells, and curcumin down-regulated paclitaxel-induced enhanced expression of Lin28 and NF-kappaB activation.	Curcumin	49-57	lin-28 homolog A	Homo sapiens	226-231
26108226-5	2015	In this study, we reported that a combination of curcumin and paclitaxel exhibited synergistic anti-proliferative and pro-apoptosis effects on Hep3B cells, and curcumin down-regulated paclitaxel-induced enhanced expression of Lin28 and NF-kappaB activation.	Curcumin	49-57	nuclear factor kappa B subunit 1	Homo sapiens	236-245
26053510-5	2015	Curcumin promotes cell growth and decreases cell impairment induced by Abeta.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	71-76
26108226-5	2015	In this study, we reported that a combination of curcumin and paclitaxel exhibited synergistic anti-proliferative and pro-apoptosis effects on Hep3B cells, and curcumin down-regulated paclitaxel-induced enhanced expression of Lin28 and NF-kappaB activation.	Curcumin	160-168	lin-28 homolog A	Homo sapiens	226-231
26108226-5	2015	In this study, we reported that a combination of curcumin and paclitaxel exhibited synergistic anti-proliferative and pro-apoptosis effects on Hep3B cells, and curcumin down-regulated paclitaxel-induced enhanced expression of Lin28 and NF-kappaB activation.	Curcumin	160-168	nuclear factor kappa B subunit 1	Homo sapiens	236-245
26053510-7	2015	Curcumin inhibits Abeta-induced increase of cellular Ca(2+) and depresses Abeta-induced phosphorylations of both NMDA receptor and cyclic AMP response element-binding protein (CREB) and activating transcription factor 1 (ATF-1).	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	18-23
26108226-6	2015	Furthermore, our results revealed that curcumin reduced Lin28 levels via mechanisms directly mediated by inhibition of NF-kappaB activity.	Curcumin	39-47	lin-28 homolog A	Homo sapiens	56-61
26108226-6	2015	Furthermore, our results revealed that curcumin reduced Lin28 levels via mechanisms directly mediated by inhibition of NF-kappaB activity.	Curcumin	39-47	nuclear factor kappa B subunit 1	Homo sapiens	119-128
26053510-7	2015	Curcumin inhibits Abeta-induced increase of cellular Ca(2+) and depresses Abeta-induced phosphorylations of both NMDA receptor and cyclic AMP response element-binding protein (CREB) and activating transcription factor 1 (ATF-1).	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	74-79
26053510-8	2015	These results indicated that curcumin inhibits Abeta-induced neuronal damage and cell death involving the prevention from intracellular Ca(2+) elevation mediated by the NMDA receptor.	Curcumin	29-37	amyloid beta precursor protein	Homo sapiens	47-52
25492022-1	2015	A multibranched Cu(II) complex CuL2 curcumin-based was synthesized and characterized by single-crystal X-ray diffraction analysis.	Curcumin	36-44	cullin 2	Homo sapiens	31-35
25826489-8	2015	On 2D cell cultures, curcumin inhibits cell tumor development and proliferation at concentrations of 15 muM, with a viability of 65.7% at 48 hours incubation time.	Curcumin	21-29	latexin	Homo sapiens	104-107
25262359-9	2015	Curcumin stimulated the expression of pro-apoptotic Bax, and inhibited the activation of anti-apoptotic Mcl-1 and Bcl-2.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	52-55
25262359-9	2015	Curcumin stimulated the expression of pro-apoptotic Bax, and inhibited the activation of anti-apoptotic Mcl-1 and Bcl-2.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	114-119
25262359-10	2015	During curcumin treatment, caspase-8 and Caspase-3 were cleaved in time and dose-dependent manners.	Curcumin	7-15	caspase 3	Homo sapiens	41-50
25262359-11	2015	Curcumin treatment also altered the expressions of apoptosis associated proteins NF-kappaB, p38 and p53.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	81-90
25262359-11	2015	Curcumin treatment also altered the expressions of apoptosis associated proteins NF-kappaB, p38 and p53.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	92-95
25262359-11	2015	Curcumin treatment also altered the expressions of apoptosis associated proteins NF-kappaB, p38 and p53.	Curcumin	0-8	tumor protein p53	Homo sapiens	100-103
26492225-0	2015	Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard Chemotherapeutic 5-Fluorouracil.	Curcumin	14-22	signal transducer and activator of transcription 3	Homo sapiens	43-48
26492225-5	2015	Curcumin, berberine, and quercetin effectively downregulated pSTAT3 levels, survivin expression, and gastric cancer cells viability in a dose-dependent manner (with corresponding IC50 values of 40.3muM, 29.2muM and 37.5muM, respectively).	Curcumin	0-8	latexin	Homo sapiens	198-201
26492225-7	2015	5-FU in combination with berberine or curcumin showed a synergistic inhibition of survivin and STAT3 level resulting in enhanced cell death in gastric cancer cells.	Curcumin	38-46	signal transducer and activator of transcription 3	Homo sapiens	95-100
25666039-0	2015	Curcumin mitigates the fibrillation of human serum albumin and diminishes the formation of reactive oxygen species.	Curcumin	0-8	albumin	Homo sapiens	45-58
25666039-2	2015	Here the impact of curcumin on amyloid formation of human serum albumin (HSA) was studied.	Curcumin	19-27	albumin	Homo sapiens	58-71
26074974-7	2015	Curcumin pretreatment significantly increased cell viability and VEGF secretion, and decreased cell injury and apoptosis via regulation of PTEN/Akt/p53 and HO-1 signal proteins expression.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	144-147
27103993-6	2015	The main component of curcumin possesses a wide range of biological activities; anti-proliferative, anti-inflammatory, and apoptotic characteristics modulated through the inactivation of pathways such as EGK and Akt/mTOR.	Curcumin	22-30	AKT serine/threonine kinase 1	Homo sapiens	212-215
27103993-6	2015	The main component of curcumin possesses a wide range of biological activities; anti-proliferative, anti-inflammatory, and apoptotic characteristics modulated through the inactivation of pathways such as EGK and Akt/mTOR.	Curcumin	22-30	mechanistic target of rapamycin kinase	Homo sapiens	216-220
25539644-5	2014	Pharmacological intervention of STAT3 was done using specific inhibitors like curcumin and stattic.	Curcumin	78-86	signal transducer and activator of transcription 3	Homo sapiens	32-37
25539644-8	2014	Pharmacological intervention of STAT3 using specific inhibitors like curcumin and Stattic that abrogated STAT3 activation resulted in loss of cellular miR-21 pool.	Curcumin	69-77	signal transducer and activator of transcription 3	Homo sapiens	32-37
25539644-8	2014	Pharmacological intervention of STAT3 using specific inhibitors like curcumin and Stattic that abrogated STAT3 activation resulted in loss of cellular miR-21 pool.	Curcumin	69-77	signal transducer and activator of transcription 3	Homo sapiens	105-110
25387343-0	2014	Nrf2 knockout attenuates the anti-inflammatory effects of phenethyl isothiocyanate and curcumin.	Curcumin	87-95	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
25431425-12	2014	Furthermore, curcumin treatment greatly reduced phosphorylation of CREB, followed by a concomitant reduction of NF-kappaB (p50 and p65) subunit activation.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	112-121
25431425-12	2014	Furthermore, curcumin treatment greatly reduced phosphorylation of CREB, followed by a concomitant reduction of NF-kappaB (p50 and p65) subunit activation.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	123-126
25431425-15	2014	These results suggest that inhibition of curcumin-induced apoptosis by PGE2 through activation of PKA, Ras, and NF-kappaB signaling pathways may provide a molecular basis for the reversal of curcumin-induced colon carcinoma cell death.	Curcumin	41-49	nuclear factor kappa B subunit 1	Homo sapiens	112-121
25431425-15	2014	These results suggest that inhibition of curcumin-induced apoptosis by PGE2 through activation of PKA, Ras, and NF-kappaB signaling pathways may provide a molecular basis for the reversal of curcumin-induced colon carcinoma cell death.	Curcumin	191-199	nuclear factor kappa B subunit 1	Homo sapiens	112-121
25521115-6	2014	The curcumin principal mechanism is the suppression of IBD inflammatory compounds (NF-kappaB) modulating immune response.	Curcumin	4-12	nuclear factor kappa B subunit 1	Homo sapiens	83-92
25523922-0	2014	Mitogen-activated protein kinase Hog1 is activated in response to curcumin exposure in the budding yeast Saccharomyces cerevisiae.	Curcumin	66-74	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	33-37
25628937-0	2015	Curcumin suppresses invasiveness and vasculogenic mimicry of squamous cell carcinoma of the larynx through the inhibition of JAK-2/STAT-3 signaling pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	131-137
25628937-5	2015	Compared to control group,there were less tumor cells permeating membrane and less formed tubes after curcumin or AG490 treatment, RT-PCR showed that the expression of MMP-2 and VEGF at mRNA level were decreased (P &lt; 0.01).	Curcumin	102-110	vascular endothelial growth factor A	Homo sapiens	178-182
25628937-8	2015	Curcumin and AG490 significantly inhibits invasion and vasculogenic mimicry of laryngeal squamous cell carcinoma in vitro, and JAK-2/STAT-3 signaling pathway promotes above processes.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	133-139
25179440-0	2014	Curcumin induces apoptosis in human neuroblastoma cells via inhibition of AKT and Foxo3a nuclear translocation.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	74-77
25240837-10	2014	The early ceramide generation by nSMase was indispensable for the later lipid accumulation, modulation of Bax, Bcl-2 and caspase 3 levels, and for reduction of cell viability in curcumin-treated cells, as all these events were inhibited by GW4869 or nSMase2 depletion.	Curcumin	178-186	BCL2 apoptosis regulator	Homo sapiens	111-116
25240837-10	2014	The early ceramide generation by nSMase was indispensable for the later lipid accumulation, modulation of Bax, Bcl-2 and caspase 3 levels, and for reduction of cell viability in curcumin-treated cells, as all these events were inhibited by GW4869 or nSMase2 depletion.	Curcumin	178-186	caspase 3	Homo sapiens	121-130
25179440-0	2014	Curcumin induces apoptosis in human neuroblastoma cells via inhibition of AKT and Foxo3a nuclear translocation.	Curcumin	0-8	forkhead box O3	Homo sapiens	82-88
25179440-7	2014	Moreover, we demonstrate that curcumin modulates anti-tumor activity through modulation of phosphatase and tensin homolog deleted on chromosome 10 and consequential inhibition of the survival Akt cell-signaling pathway.	Curcumin	30-38	AKT serine/threonine kinase 1	Homo sapiens	192-195
25179295-7	2014	More importantly, curcumin suppressed FoxM1 expression, selectively inhibited cell survival as well as the combination of curcumin and doxorubicin exhibited a more inhibitory effect in primary CD34(+) AML cells, while showing limited lethality in normal CD34(+) hematopoietic progenitors.	Curcumin	18-26	CD34 molecule	Homo sapiens	193-197
25179295-7	2014	More importantly, curcumin suppressed FoxM1 expression, selectively inhibited cell survival as well as the combination of curcumin and doxorubicin exhibited a more inhibitory effect in primary CD34(+) AML cells, while showing limited lethality in normal CD34(+) hematopoietic progenitors.	Curcumin	18-26	CD34 molecule	Homo sapiens	254-258
25179295-7	2014	More importantly, curcumin suppressed FoxM1 expression, selectively inhibited cell survival as well as the combination of curcumin and doxorubicin exhibited a more inhibitory effect in primary CD34(+) AML cells, while showing limited lethality in normal CD34(+) hematopoietic progenitors.	Curcumin	122-130	CD34 molecule	Homo sapiens	193-197
25179295-7	2014	More importantly, curcumin suppressed FoxM1 expression, selectively inhibited cell survival as well as the combination of curcumin and doxorubicin exhibited a more inhibitory effect in primary CD34(+) AML cells, while showing limited lethality in normal CD34(+) hematopoietic progenitors.	Curcumin	122-130	CD34 molecule	Homo sapiens	254-258
25530715-5	2014	Curcumin"s effect on PI3K (phosphatidylinositol 3-kinase) /Akt and its substrates Foxo1 and Foxo3a were then studied by Western Blotting.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	59-62
25554986-6	2014	The present data indicated that thymoquinone and curcumin significantly prevented the gentamicin-induced elevations of serum AST, ALT and LDH activities as well as tumor necrosis factor alpha (TNF-alpha) and total bilirubin levels.	Curcumin	49-57	tumor necrosis factor	Rattus norvegicus	164-191
25554986-6	2014	The present data indicated that thymoquinone and curcumin significantly prevented the gentamicin-induced elevations of serum AST, ALT and LDH activities as well as tumor necrosis factor alpha (TNF-alpha) and total bilirubin levels.	Curcumin	49-57	tumor necrosis factor	Rattus norvegicus	193-202
25554986-9	2014	The elevated proapoptotic proteins caspase 3 and Bax expression in cytoplasm and nucleus of hepatocytes of gentamicin-injected rats were reduced to normal value as a result of thymoquinone and curcumin administration while the lowered expression of antiapoptotic protein Bcl-2 was increased.	Curcumin	193-201	BCL2, apoptosis regulator	Rattus norvegicus	271-276
25310451-6	2014	By MTT and colony formation assays, we found that curcumin, an inhibitor of the WT1 protein, inhibited cell proliferation and clonogenicity in a time- and dose-dependent manner.	Curcumin	50-58	WT1 transcription factor	Homo sapiens	80-83
25310360-7	2014	A low dose of curcumin (10 or 20 microM) attenuated both the macrophage cell growth inhibition and the increase in the expression of IL-6 and TNF-alpha induced by P19.	Curcumin	14-22	interleukin 6	Homo sapiens	133-137
25310360-7	2014	A low dose of curcumin (10 or 20 microM) attenuated both the macrophage cell growth inhibition and the increase in the expression of IL-6 and TNF-alpha induced by P19.	Curcumin	14-22	tumor necrosis factor	Homo sapiens	142-151
25310360-8	2014	Curcumin also decreased the phosphorylation of JNK and p38 that were induced by P19.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	47-50
25310360-8	2014	Curcumin also decreased the phosphorylation of JNK and p38 that were induced by P19.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	55-58
25310360-10	2014	These data suggest that curcumin may protect macrophages from P19-induced cell apoptosis via a TLR2-mediated JNK-dependent pathway.	Curcumin	24-32	toll like receptor 2	Homo sapiens	95-99
25310360-10	2014	These data suggest that curcumin may protect macrophages from P19-induced cell apoptosis via a TLR2-mediated JNK-dependent pathway.	Curcumin	24-32	mitogen-activated protein kinase 8	Homo sapiens	109-112
25530715-0	2014	The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway.	Curcumin	92-100	AKT serine/threonine kinase 1	Homo sapiens	130-133
25530715-5	2014	Curcumin"s effect on PI3K (phosphatidylinositol 3-kinase) /Akt and its substrates Foxo1 and Foxo3a were then studied by Western Blotting.	Curcumin	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	27-56
25530715-5	2014	Curcumin"s effect on PI3K (phosphatidylinositol 3-kinase) /Akt and its substrates Foxo1 and Foxo3a were then studied by Western Blotting.	Curcumin	0-8	forkhead box O1	Homo sapiens	82-87
25530715-5	2014	Curcumin"s effect on PI3K (phosphatidylinositol 3-kinase) /Akt and its substrates Foxo1 and Foxo3a were then studied by Western Blotting.	Curcumin	0-8	forkhead box O3	Homo sapiens	92-98
25530715-7	2014	Finally, WST-1 assay was tested to explore the concomitant treatment with curcumin and the inhibition of PKB or SKP2 signaling on curcumin sensitivity in MCF-7 and MDA-MB-231 cells.	Curcumin	130-138	AKT serine/threonine kinase 1	Homo sapiens	105-108
25530715-8	2014	RESULTS: We demonstrated MCF-7 and MDA-MB-231 cells exhibited differential responses to curcumin by WST-1 and clonogenic assay (MDA-MB-231 cells was sensitive, and MCF-7 cells was resistant), which were found to be related to the differential curcumin-mediated regulation of SKP2-Cip/Kips (p21 and p27 but not p57) signaling.	Curcumin	88-96	cyclin dependent kinase inhibitor 1C	Homo sapiens	310-313
25530715-9	2014	The differential cellular responses were further linked to the converse effects of curcumin on PI3K/Akt and its substrates Foxo1 and Foxo3a.	Curcumin	83-91	AKT serine/threonine kinase 1	Homo sapiens	100-103
25530715-9	2014	The differential cellular responses were further linked to the converse effects of curcumin on PI3K/Akt and its substrates Foxo1 and Foxo3a.	Curcumin	83-91	forkhead box O1	Homo sapiens	123-128
25530715-9	2014	The differential cellular responses were further linked to the converse effects of curcumin on PI3K/Akt and its substrates Foxo1 and Foxo3a.	Curcumin	83-91	forkhead box O3	Homo sapiens	133-139
25530715-10	2014	Importantly, PI3K inhibitor wortmannin could counteract both curcumin-induced phosphorylation of Akt and up-regulation of SKP2 in MCF-7 cells.	Curcumin	61-69	AKT serine/threonine kinase 1	Homo sapiens	97-100
25530715-12	2014	CONCLUSIONS: Our study established PI3K/Akt-SKP2-Cip/Kips signaling pathway is involved in the mechanism of action of curcumin and revealed that the discrepant modulation of this pathway by curcumin is responsible for the differential susceptibilities of these two cell types to curcumin.	Curcumin	118-126	AKT serine/threonine kinase 1	Homo sapiens	40-43
25530715-12	2014	CONCLUSIONS: Our study established PI3K/Akt-SKP2-Cip/Kips signaling pathway is involved in the mechanism of action of curcumin and revealed that the discrepant modulation of this pathway by curcumin is responsible for the differential susceptibilities of these two cell types to curcumin.	Curcumin	190-198	AKT serine/threonine kinase 1	Homo sapiens	40-43
25530715-12	2014	CONCLUSIONS: Our study established PI3K/Akt-SKP2-Cip/Kips signaling pathway is involved in the mechanism of action of curcumin and revealed that the discrepant modulation of this pathway by curcumin is responsible for the differential susceptibilities of these two cell types to curcumin.	Curcumin	190-198	AKT serine/threonine kinase 1	Homo sapiens	40-43
25369140-0	2014	Oral administration of nano-emulsion curcumin in mice suppresses inflammatory-induced NFkappaB signaling and macrophage migration.	Curcumin	37-45	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-94
25489242-6	2014	Cytotoxicity evaluations showed that half maximal inhibitory concentrations of free curcumin and curcumin-loaded mPEG-OA for the U87MG cancer cell line were 48 muM and 24 muM, respectively.	Curcumin	84-92	latexin	Homo sapiens	160-163
25489242-6	2014	Cytotoxicity evaluations showed that half maximal inhibitory concentrations of free curcumin and curcumin-loaded mPEG-OA for the U87MG cancer cell line were 48 muM and 24 muM, respectively.	Curcumin	84-92	latexin	Homo sapiens	171-174
25489242-6	2014	Cytotoxicity evaluations showed that half maximal inhibitory concentrations of free curcumin and curcumin-loaded mPEG-OA for the U87MG cancer cell line were 48 muM and 24 muM, respectively.	Curcumin	97-105	latexin	Homo sapiens	160-163
25489242-6	2014	Cytotoxicity evaluations showed that half maximal inhibitory concentrations of free curcumin and curcumin-loaded mPEG-OA for the U87MG cancer cell line were 48 muM and 24 muM, respectively.	Curcumin	97-105	latexin	Homo sapiens	171-174
25407718-0	2014	Curcumin protects against CCl4-induced liver fibrosis in rats by inhibiting HIF-1alpha through an ERK-dependent pathway.	Curcumin	0-8	C-C motif chemokine ligand 4	Rattus norvegicus	26-30
25407718-0	2014	Curcumin protects against CCl4-induced liver fibrosis in rats by inhibiting HIF-1alpha through an ERK-dependent pathway.	Curcumin	0-8	Eph receptor B1	Rattus norvegicus	98-101
25407718-9	2014	The alleviation with curcumin treatment was associated with inhibition of HIF-1alpha and phosphor-ERK.	Curcumin	21-29	Eph receptor B1	Rattus norvegicus	98-101
25407718-10	2014	This study indicates that curcumin alleviates fibrosis by reducing the expression of HIF-1alpha partly through the ERK pathway.	Curcumin	26-34	Eph receptor B1	Rattus norvegicus	115-118
25253691-0	2014	A combination of curcumin with either gramicidin or ouabain selectively kills cells that express the multidrug resistance-linked ABCG2 transporter.	Curcumin	17-25	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	129-134
25253691-2	2014	The approach is based on specific stimulation of ATP hydrolysis by ABCG2 transporters with subtoxic doses of curcumin combined with stimulation of ATP hydrolysis by Na(+),K(+)-ATPase with subtoxic doses of gramicidin A or ouabain.	Curcumin	109-117	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	67-72
25369140-5	2014	Using transgenic mice harboring an NFkappaB-luciferase reporter gene, we demonstrate a novel application of this in vivo inflammatory model to test the efficacy of NEC administration by bioluminescent imaging and show that LPS-induced NFkappaB activity was suppressed with NEC compared to an equivalent amount of curcumin in aqueous suspension.	Curcumin	313-321	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	35-43
25369140-5	2014	Using transgenic mice harboring an NFkappaB-luciferase reporter gene, we demonstrate a novel application of this in vivo inflammatory model to test the efficacy of NEC administration by bioluminescent imaging and show that LPS-induced NFkappaB activity was suppressed with NEC compared to an equivalent amount of curcumin in aqueous suspension.	Curcumin	313-321	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	235-243
25369140-7	2014	Mechanistically, curcumin blocked LPS-induced phosphorylation of the p65 subunit of NFkappaB and IkappaBalpha in murine macrophages.	Curcumin	17-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	84-92
25369140-10	2014	These data demonstrate that curcumin can suppress inflammation by inhibiting macrophage migration via NFkappaB and MCP-1 inhibition and establish that NEC is an effective therapeutic formulation to increase the bioavailability of curcumin in order to facilitate this response.	Curcumin	28-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	102-110
25369140-10	2014	These data demonstrate that curcumin can suppress inflammation by inhibiting macrophage migration via NFkappaB and MCP-1 inhibition and establish that NEC is an effective therapeutic formulation to increase the bioavailability of curcumin in order to facilitate this response.	Curcumin	28-36	mast cell protease 1	Mus musculus	115-120
25131506-8	2014	Moreover, pre-treatment with curcumin attenuated LPS-induced microglial activation and overproduction of pro-inflammatory cytokine (interleukin-1beta and tumor necrosis factor-alpha), as well as the levels of inducible nitric oxide synthase and cyclooxygenase-2 mRNA in the hippocampus and prefrontal cortex (PFC).	Curcumin	29-37	interleukin 1 beta	Mus musculus	132-181
24474673-9	2014	In addition, the administration of curcumin significantly decreased the positive expressions of NF-kappa B p65 and CX3CR1 in spinal cord and DRG (P&lt;0.05).	Curcumin	35-43	synaptotagmin 1	Rattus norvegicus	107-110
25201174-6	2014	When curcumin decreased the acetylation level of H3K9 at the Egr-1 binding site, the binding of Egr-1 to promoter region II and GDNF mRNA levels significantly decreased.	Curcumin	5-13	early growth response 1	Rattus norvegicus	61-66
25201174-6	2014	When curcumin decreased the acetylation level of H3K9 at the Egr-1 binding site, the binding of Egr-1 to promoter region II and GDNF mRNA levels significantly decreased.	Curcumin	5-13	early growth response 1	Rattus norvegicus	96-101
24474673-10	2014	CONCLUSION: Our study suggests that curcumin could ameliorate the CCI-induced neuropathic pain, probably through inhibiting CX3CR1 expression by the activation of NF-kappa B p65 in spinal cord and DRG.	Curcumin	36-44	synaptotagmin 1	Rattus norvegicus	174-177
25195681-0	2014	Curcumin inhibits the proliferation and invasiveness of MHCC97-H cells via p38 signaling pathway.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	75-78
24896104-9	2014	miR-125a-5p inhibited the expression of tumour protein 53 (TP53), and curcumin treatment up-regulated the expression of TP53.	Curcumin	70-78	tumor protein p53	Homo sapiens	120-124
24896104-10	2014	Taken together, these results indicate that curcumin exerted inhibitory effects on NPC by inhibiting the expression of miR-125a-5p and, subsequently, enhancing the expression of TP53.	Curcumin	44-52	tumor protein p53	Homo sapiens	178-182
25195681-5	2014	Curcumin also decreased the expression and activity of matrix metalloproteinases (MMP)-2 and MMP-9, and reduced p38 phosphorylation.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	112-115
25195681-6	2014	Combination treatment of HCC cells with curcumin and SB203580 (a p38 signaling pathway inhibitor), generated a synergistic effect on the expression of MMP-2 and MMP-9, suggesting that the anti-metastatic effect of curcumin on HCC may involve a p38 signaling pathway.	Curcumin	40-48	mitogen-activated protein kinase 14	Homo sapiens	65-68
25195681-6	2014	Combination treatment of HCC cells with curcumin and SB203580 (a p38 signaling pathway inhibitor), generated a synergistic effect on the expression of MMP-2 and MMP-9, suggesting that the anti-metastatic effect of curcumin on HCC may involve a p38 signaling pathway.	Curcumin	40-48	mitogen-activated protein kinase 14	Homo sapiens	244-247
25196431-0	2014	Curcumin prevents diabetic nephropathy against inflammatory response via reversing caveolin-1 Tyr14 phosphorylation influenced TLR4 activation.	Curcumin	0-8	caveolin 1	Rattus norvegicus	83-93
25461551-10	2014	Pathological studies also revealed that intranasal curcumin alleviate PQ-induced pulmonary damage and pro-inflammatory cytokine levels like tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO).	Curcumin	51-59	tumor necrosis factor	Mus musculus	140-167
25461551-10	2014	Pathological studies also revealed that intranasal curcumin alleviate PQ-induced pulmonary damage and pro-inflammatory cytokine levels like tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO).	Curcumin	51-59	tumor necrosis factor	Mus musculus	169-178
25196431-0	2014	Curcumin prevents diabetic nephropathy against inflammatory response via reversing caveolin-1 Tyr14 phosphorylation influenced TLR4 activation.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	127-131
25196431-4	2014	In this study, we hypothesized that curcumin affected high glucose (HG)-induced inflammation profiles in vivo and in vitro and then prevented renal injury in diabetic rats via reversing cav-1 Tyr(14) phosphorylation that influenced TLR4 activation.	Curcumin	36-44	caveolin 1	Rattus norvegicus	186-191
25175917-9	2014	Like curcumin, DEC prevents NF-kappaB activation by reducing NF-kappaB p65 phosphorylation and IkappaBalpha degradation.	Curcumin	5-13	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	95-107
25196431-4	2014	In this study, we hypothesized that curcumin affected high glucose (HG)-induced inflammation profiles in vivo and in vitro and then prevented renal injury in diabetic rats via reversing cav-1 Tyr(14) phosphorylation that influenced TLR4 activation.	Curcumin	36-44	toll-like receptor 4	Rattus norvegicus	232-236
25196431-7	2014	In vivo, curcumin improved histological abnormalities and fibrosis of a diabetic kidney, inhibited renal inflammatory gene expression and reduced cav-1 phosphorylation at Tyr(14) and the expression of TLR4.	Curcumin	9-17	caveolin 1	Rattus norvegicus	146-151
25196431-7	2014	In vivo, curcumin improved histological abnormalities and fibrosis of a diabetic kidney, inhibited renal inflammatory gene expression and reduced cav-1 phosphorylation at Tyr(14) and the expression of TLR4.	Curcumin	9-17	toll-like receptor 4	Rattus norvegicus	201-205
25196431-8	2014	Pretreatment of podocytes with curcumin reduced HG-stimulated production of proinflammatory cytokines, TLR4 and the phosphorylation of cav-1.	Curcumin	31-39	toll-like receptor 4	Rattus norvegicus	103-107
25196431-8	2014	Pretreatment of podocytes with curcumin reduced HG-stimulated production of proinflammatory cytokines, TLR4 and the phosphorylation of cav-1.	Curcumin	31-39	caveolin 1	Rattus norvegicus	135-140
25196431-9	2014	But immunohistochemistry in rat kidney showed that the elevation of TLR4 expression is more evident in the renal interstitum than in the glomerulus where podocytes are located, and the possibility that the anti-inflammatory effects of curcumin on other cells in the kidney may be mediated through the same molecular pathways as in podocytes.	Curcumin	235-243	toll-like receptor 4	Rattus norvegicus	68-72
25196431-10	2014	Our study suggests that curcumin treatment ameliorates DN via inhibition of inflammatory gene expression by reversing caveolin-1 Tyr(14) phosphorylation that influenced TLR4 activation.	Curcumin	24-32	caveolin 1	Rattus norvegicus	118-128
25196431-10	2014	Our study suggests that curcumin treatment ameliorates DN via inhibition of inflammatory gene expression by reversing caveolin-1 Tyr(14) phosphorylation that influenced TLR4 activation.	Curcumin	24-32	toll-like receptor 4	Rattus norvegicus	169-173
25297556-0	2014	Resveratrol and curcumin enhance pancreatic beta-cell function by inhibiting phosphodiesterase activity.	Curcumin	16-24	phosphodiesterase 10A	Homo sapiens	77-94
25159739-0	2014	Curcumin ameliorates cognitive deficits heavy ion irradiation-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	120-124
24975470-7	2014	Curcumin reduced OGD/R-induced accumulation of reactive oxygen species and inhibited the mitochondrial apoptosis pathway, as indicated by reduced release of cytochrome c and apoptosis-inducing factor and maintenance of both the mitochondrial membrane potential and the Bax/Bcl-2 ratio.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	273-278
24491024-0	2014	Long-term effect of curcumin down-regulates expression of tumor necrosis factor-alpha and interleukin-6 via modulation of E26 transformation-specific protein and nuclear factor-kappaB transcription factors in livers of lymphoma bearing mice.	Curcumin	20-28	tumor necrosis factor	Mus musculus	58-85
24491024-0	2014	Long-term effect of curcumin down-regulates expression of tumor necrosis factor-alpha and interleukin-6 via modulation of E26 transformation-specific protein and nuclear factor-kappaB transcription factors in livers of lymphoma bearing mice.	Curcumin	20-28	interleukin 6	Mus musculus	90-103
24491024-3	2014	The present work was aimed to analyze the anti-carcinogenic action of curcumin on the expression of TNF-alpha and IL-6 even after withdrawal of treatment.	Curcumin	70-78	tumor necrosis factor	Mus musculus	100-109
24491024-3	2014	The present work was aimed to analyze the anti-carcinogenic action of curcumin on the expression of TNF-alpha and IL-6 even after withdrawal of treatment.	Curcumin	70-78	interleukin 6	Mus musculus	114-118
24491024-4	2014	Up-regulated expressions of TNF-alpha and IL-6 in terms of mRNA and protein levels in lymphoma bearing mice were significantly down-regulated by curcumin as compared to normal.	Curcumin	145-153	tumor necrosis factor	Mus musculus	28-37
24491024-4	2014	Up-regulated expressions of TNF-alpha and IL-6 in terms of mRNA and protein levels in lymphoma bearing mice were significantly down-regulated by curcumin as compared to normal.	Curcumin	145-153	interleukin 6	Mus musculus	42-46
24491024-5	2014	Electrophoretic mobility shift assay (EMSA) results revealed that curcumin reduced binding of nuclear protein with ETS and NF-kappaB binding elements of TNF-alpha and IL-6 promoters, respectively.	Curcumin	66-74	tumor necrosis factor	Mus musculus	153-162
24491024-5	2014	Electrophoretic mobility shift assay (EMSA) results revealed that curcumin reduced binding of nuclear protein with ETS and NF-kappaB binding elements of TNF-alpha and IL-6 promoters, respectively.	Curcumin	66-74	interleukin 6	Mus musculus	167-171
24491024-7	2014	In continuation, the present study suggests that the long-term effect of curcumin may contribute to attenuate cancer progression via the down-regulation of TNF-alpha and IL-6 modulated by E26 transformation-specific protein (ETS) and nuclear factor-kappaB (NF-kappaB), respectively.	Curcumin	73-81	tumor necrosis factor	Mus musculus	156-165
24491024-7	2014	In continuation, the present study suggests that the long-term effect of curcumin may contribute to attenuate cancer progression via the down-regulation of TNF-alpha and IL-6 modulated by E26 transformation-specific protein (ETS) and nuclear factor-kappaB (NF-kappaB), respectively.	Curcumin	73-81	interleukin 6	Mus musculus	170-174
25172633-10	2014	Between 2 and 4 h following curcumin treatment, p53 levels increased with maximum levels reached by 8 h. Thus, curcumin homing to the nucleolus induces redistribution of p14(ARF) to the nucleoplasm where interaction with MDM2 leads to stabilization of p53, with subsequent initiation of apoptosis.	Curcumin	28-36	tumor protein p53	Homo sapiens	48-51
25172633-10	2014	Between 2 and 4 h following curcumin treatment, p53 levels increased with maximum levels reached by 8 h. Thus, curcumin homing to the nucleolus induces redistribution of p14(ARF) to the nucleoplasm where interaction with MDM2 leads to stabilization of p53, with subsequent initiation of apoptosis.	Curcumin	28-36	tumor protein p53	Homo sapiens	252-255
25172633-10	2014	Between 2 and 4 h following curcumin treatment, p53 levels increased with maximum levels reached by 8 h. Thus, curcumin homing to the nucleolus induces redistribution of p14(ARF) to the nucleoplasm where interaction with MDM2 leads to stabilization of p53, with subsequent initiation of apoptosis.	Curcumin	111-119	tumor protein p53	Homo sapiens	48-51
25172633-10	2014	Between 2 and 4 h following curcumin treatment, p53 levels increased with maximum levels reached by 8 h. Thus, curcumin homing to the nucleolus induces redistribution of p14(ARF) to the nucleoplasm where interaction with MDM2 leads to stabilization of p53, with subsequent initiation of apoptosis.	Curcumin	111-119	tumor protein p53	Homo sapiens	252-255
25216080-0	2014	Curcumin inhibits hypoxia inducible factor-1alpha-induced epithelial-mesenchymal transition in HepG2 hepatocellular carcinoma cells.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-49
25216080-7	2014	The results showed that curcumin significantly decreased hypoxia-induced hypoxia inducible factor-1alpha (HIF-1alpha) protein level in HepG2 cells.	Curcumin	24-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-104
25216080-7	2014	The results showed that curcumin significantly decreased hypoxia-induced hypoxia inducible factor-1alpha (HIF-1alpha) protein level in HepG2 cells.	Curcumin	24-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
25394974-4	2014	Through IL-1 antagonists and substances, such as curcumin IL-1-induced VEGF-A expression and angiogenesis can be blocked; therefore, IL-1-blockade provides an interesting therapy target for chondrosarcoma.	Curcumin	49-57	vascular endothelial growth factor A	Homo sapiens	71-77
25159739-7	2014	Our study confirmed the antagonistic roles of curcumin to counteract radiation-induced cerebral injury in vivo and suggested that the potent Nrf2 activation capability might be valuable for the protective effects of curcumin against radiation.	Curcumin	216-224	NFE2 like bZIP transcription factor 2	Homo sapiens	141-145
26027129-1	2014	OBJECTIVE: To investigate the synergism inhibition of curcumin combined with cisplatin on T24 bladder carcinoma cells and the down-regulating effect of curcumin on the Keapl-Nrf2 pathway, a well recognized anti-drug pathway in almost drugged tumor cells.	Curcumin	152-160	NFE2 like bZIP transcription factor 2	Homo sapiens	174-178
25164566-5	2014	The curcumin-responsive element of the PCSK9 promoter, a binding site for hepatocyte nuclear factor 1alpha (HNF-1alpha), was also identified.	Curcumin	4-12	HNF1 homeobox A	Homo sapiens	74-106
25164566-5	2014	The curcumin-responsive element of the PCSK9 promoter, a binding site for hepatocyte nuclear factor 1alpha (HNF-1alpha), was also identified.	Curcumin	4-12	HNF1 homeobox A	Homo sapiens	108-118
25164566-6	2014	We demonstrated that curcumin reduced the nuclear abundance of hepatocyte nuclear factor 1alpha, resulting in its attenuated interaction with the PCSK9 promoter and leading to a downregulation of PCSK9 expression.	Curcumin	21-29	HNF1 homeobox A	Homo sapiens	63-95
26027129-6	2014	After the treatment with different concentrations of curcumin, Nuclear Nrf2 was decreased but Keapl was increased, and GSTP1 and NQO1 were decreased.	Curcumin	53-61	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
26027129-6	2014	After the treatment with different concentrations of curcumin, Nuclear Nrf2 was decreased but Keapl was increased, and GSTP1 and NQO1 were decreased.	Curcumin	53-61	NAD(P)H quinone dehydrogenase 1	Homo sapiens	129-133
26027129-8	2014	The Keapl-Nrf2 pathway in T24 cells is down-regulated by curcumin.	Curcumin	57-65	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
26027129-9	2014	The expression of typical phase I enzymes (GSTP1 and NQO1) mediated by Nrf2 are decreased by curcumin.	Curcumin	93-101	NAD(P)H quinone dehydrogenase 1	Homo sapiens	53-57
26027129-9	2014	The expression of typical phase I enzymes (GSTP1 and NQO1) mediated by Nrf2 are decreased by curcumin.	Curcumin	93-101	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
25315241-0	2014	Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/beta-catenin negative feedback loop.	Curcumin	0-8	cadherin 1	Homo sapiens	70-80
25157104-3	2014	In fact, curcumin-induced up-regulation of SMAR1 ensures recruitment of SMAR1-HDAC1 repressor complex at the LCR and E6 MAR sequences, thereby decreasing histone acetylation at H3K9 and H3K18, leading to reorientation of the chromatin.	Curcumin	9-17	BTG3 associated nuclear protein	Homo sapiens	43-48
25157104-3	2014	In fact, curcumin-induced up-regulation of SMAR1 ensures recruitment of SMAR1-HDAC1 repressor complex at the LCR and E6 MAR sequences, thereby decreasing histone acetylation at H3K9 and H3K18, leading to reorientation of the chromatin.	Curcumin	9-17	BTG3 associated nuclear protein	Homo sapiens	72-77
25157104-3	2014	In fact, curcumin-induced up-regulation of SMAR1 ensures recruitment of SMAR1-HDAC1 repressor complex at the LCR and E6 MAR sequences, thereby decreasing histone acetylation at H3K9 and H3K18, leading to reorientation of the chromatin.	Curcumin	9-17	histone deacetylase 1	Homo sapiens	78-83
25123790-5	2014	Moreover, curcumin was shown to induce phase II detoxifying/antioxidant enzymes HO-1 and NQO1 through the activation of nuclear factor erythroid-derived 2-like 2 (Nrf2).	Curcumin	10-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	120-161
25123790-5	2014	Moreover, curcumin was shown to induce phase II detoxifying/antioxidant enzymes HO-1 and NQO1 through the activation of nuclear factor erythroid-derived 2-like 2 (Nrf2).	Curcumin	10-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	163-167
25123790-6	2014	In summary, the protective mechanisms of curcumin against TCBQ-induced hepatoxicity may be related to the attenuation of oxidative stress, along with the inhibition of inflammatory response via the activation of Nrf2 signaling.	Curcumin	41-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	212-216
25360677-8	2014	Low-dose curcumin mediated effects on OECs demonstrate cell-type specific stimulation of p38 and ERK kinases.	Curcumin	9-17	mitogen-activated protein kinase 1	Mus musculus	97-100
25315241-8	2014	RESULTS: Here, we report that bCSCs are endowed with aggravated migration property due to the inherent suppression of the tumor suppressor, E-cadherin, which is restored by curcumin.	Curcumin	173-181	cadherin 1	Homo sapiens	140-150
25315241-12	2014	CONCLUSIONS: Cumulatively, our findings disclose that curcumin inhibits bCSC migration by amplifying E-cadherin/beta-catenin negative feedback loop.	Curcumin	54-62	cadherin 1	Homo sapiens	101-111
25134928-0	2014	A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer"s disease.	Curcumin	15-23	amyloid beta precursor protein	Homo sapiens	87-99
24723245-0	2014	Curcumin inhibits TLR2/4-NF-kappaB signaling pathway and attenuates brain damage in permanent focal cerebral ischemia in rats.	Curcumin	0-8	toll-like receptor 2	Rattus norvegicus	18-22
25041840-8	2014	Furthermore, we found that curcumin significantly decreased the expression of Phosphatidylinositol 3-Kinase (PI3K), phosphorylated Akt and rapamycin (mTOR) at protein levels, respectively.	Curcumin	27-35	thymoma viral proto-oncogene 1	Mus musculus	131-134
25041840-9	2014	Taken together, our data suggests that curcumin inhibits Abeta generation and induces of autophagy by downregulating PI3K/Akt/mTOR signaling pathway, and further shows a neuroprotective effect.	Curcumin	39-47	thymoma viral proto-oncogene 1	Mus musculus	122-125
25456852-8	2014	Furthermore, curcumin inhibited HG-induced caveolin-1 (cav-1) Tyr(14) phosphorylation associating with the suppression of stabilization of cav-1 and beta-catenin.	Curcumin	13-21	caveolin 1	Rattus norvegicus	43-53
25456852-8	2014	Furthermore, curcumin inhibited HG-induced caveolin-1 (cav-1) Tyr(14) phosphorylation associating with the suppression of stabilization of cav-1 and beta-catenin.	Curcumin	13-21	caveolin 1	Rattus norvegicus	55-60
25456852-8	2014	Furthermore, curcumin inhibited HG-induced caveolin-1 (cav-1) Tyr(14) phosphorylation associating with the suppression of stabilization of cav-1 and beta-catenin.	Curcumin	13-21	caveolin 1	Rattus norvegicus	139-144
25456852-9	2014	CONCLUSIONS: In summary, these findings suggest that curcumin prevents EMT of podocytes, proteinuria, and kidney injury in DN by suppressing the phosphorylation of cav-1, and increasing stabilization of cav-1 and beta-catenin.	Curcumin	53-61	caveolin 1	Rattus norvegicus	164-169
25456852-9	2014	CONCLUSIONS: In summary, these findings suggest that curcumin prevents EMT of podocytes, proteinuria, and kidney injury in DN by suppressing the phosphorylation of cav-1, and increasing stabilization of cav-1 and beta-catenin.	Curcumin	53-61	caveolin 1	Rattus norvegicus	203-208
24706026-2	2014	It has been reported that curcumin attenuates allergic airway inflammation in mice through inhibiting NF-kappaB and its downstream transcription factor GATA3.	Curcumin	26-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	102-111
25041840-0	2014	Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice.	Curcumin	53-61	thymoma viral proto-oncogene 1	Mus musculus	23-26
25456852-0	2014	Curcumin ameliorates epithelial-to-mesenchymal transition of podocytes in vivo and in vitro via regulating caveolin-1.	Curcumin	0-8	caveolin 1	Rattus norvegicus	107-117
25456852-5	2014	And we investigated the effect of curcumin on HG-induced phosphorylation of cav-1 on the stability cav-1 and beta-catenin using immunoprecipitation and fluorescence microscopy analysis.	Curcumin	34-42	caveolin 1	Rattus norvegicus	76-81
25456852-5	2014	And we investigated the effect of curcumin on HG-induced phosphorylation of cav-1 on the stability cav-1 and beta-catenin using immunoprecipitation and fluorescence microscopy analysis.	Curcumin	34-42	caveolin 1	Rattus norvegicus	99-104
25016976-0	2014	The effect of co-delivery of paclitaxel and curcumin by transferrin-targeted PEG-PE-based mixed micelles on resistant ovarian cancer in 3-D spheroids and in vivo tumors.	Curcumin	44-52	transferrin	Homo sapiens	56-67
25027711-6	2014	TPA-induced phosphorylation of Akt, S6 kinase (S6K), and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) in mouse skin was lower in the curcumin group than in the control group.	Curcumin	158-166	thymoma viral proto-oncogene 1	Mus musculus	31-34
25027711-7	2014	Curcumin treatment inhibited IGF-1-induced phosphorylation of the IGF-1 receptor, insulin receptor substrate-1, Akt, S6K, and 4EBP1 in the mouse keratinocyte cell line, C50 in a dose-dependent manner.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	112-115
25064633-0	2014	Curcumin inhibits monocyte chemoattractant protein-1 expression and enhances cholesterol efflux by suppressing the c-Jun N-terminal kinase pathway in macrophage.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	115-138
25064633-8	2014	Curcumin suppressed the phosphorylation of JNK and activation of NF-kappaB.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	43-46
25064633-8	2014	Curcumin suppressed the phosphorylation of JNK and activation of NF-kappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	65-74
25064633-11	2014	CONCLUSION: Curcumin suppresses MCP-1 production induced by ox-LDL via the JNK pathway and NK-kappaB pathway, while enhances cholesterol efflux in macrophage via suppressing the JNK pathway and activating the LXR-ABCA1/SR-BI pathway, which indicate that the vascular protective effect of curcumin is related to anti-inflammation and anti-atherosclerosis.	Curcumin	12-20	mitogen-activated protein kinase 8	Homo sapiens	75-78
24723245-3	2014	In this study, we investigated whether curcumin inhibits the activation of TLR2/4-NF-kappaB signaling pathway in rats of permanent focal cerebral ischemia.	Curcumin	39-47	toll-like receptor 2	Rattus norvegicus	75-79
24723245-13	2014	In addition, curcumin attenuated the release of TNF-alpha and IL-1beta in blood.	Curcumin	13-21	tumor necrosis factor	Rattus norvegicus	48-57
24723245-13	2014	In addition, curcumin attenuated the release of TNF-alpha and IL-1beta in blood.	Curcumin	13-21	interleukin 1 beta	Rattus norvegicus	62-70
24723245-15	2014	The neuroprotective effect and anti-inflammatory property of curcumin in cerebral ischemia might be associated with the inhibition of TLR2/4-NF-kappaB signaling pathway.	Curcumin	61-69	toll-like receptor 2	Rattus norvegicus	134-138
25064633-11	2014	CONCLUSION: Curcumin suppresses MCP-1 production induced by ox-LDL via the JNK pathway and NK-kappaB pathway, while enhances cholesterol efflux in macrophage via suppressing the JNK pathway and activating the LXR-ABCA1/SR-BI pathway, which indicate that the vascular protective effect of curcumin is related to anti-inflammation and anti-atherosclerosis.	Curcumin	12-20	mitogen-activated protein kinase 8	Homo sapiens	178-181
24963995-13	2014	In both H2O2-treated BV-2 microglia and glaucoma models, caspase 3, cytochrome c, and BAX were downregulated and BCL2 was upregulated in the curcumin-treated group.	Curcumin	141-149	BCL2, apoptosis regulator	Rattus norvegicus	113-117
25069637-0	2014	Suppression of the TGF-beta/Smad signaling pathway and inhibition of hepatic stellate cell proliferation play a role in the hepatoprotective effects of curcumin against alcohol-induced hepatic fibrosis.	Curcumin	152-160	transforming growth factor beta 1	Homo sapiens	19-27
25069637-5	2014	We also found that by suppressing the transforming growth factor-beta (TGF-beta)/Smad signaling pathway, the administration of curcumin impaired the production of extracellular matrix proteins in alcohol-stimulated HSCs.	Curcumin	127-135	transforming growth factor beta 1	Homo sapiens	38-69
25069637-5	2014	We also found that by suppressing the transforming growth factor-beta (TGF-beta)/Smad signaling pathway, the administration of curcumin impaired the production of extracellular matrix proteins in alcohol-stimulated HSCs.	Curcumin	127-135	transforming growth factor beta 1	Homo sapiens	71-79
25069637-6	2014	These results indicate that curcumin exerts its hepatoprotective effects against alcohol-induced hepatic fibrosis by inhibiting the proliferation and inducing the apoptosis of HSCs by stimulating ER stress and deactivating HSCs by suppressing the TGF-beta/Smad signaling pathway.	Curcumin	28-36	transforming growth factor beta 1	Homo sapiens	247-255
25070648-5	2014	Furthermore, western blot analysis revealed that curcumin induced p53 and p21(WAF1/CIP1) expression with a concomitant decrease in proliferating cell nuclear antigen protein levels (P&lt;0.05).	Curcumin	49-57	tumor protein p53	Homo sapiens	66-69
25070648-5	2014	Furthermore, western blot analysis revealed that curcumin induced p53 and p21(WAF1/CIP1) expression with a concomitant decrease in proliferating cell nuclear antigen protein levels (P&lt;0.05).	Curcumin	49-57	cyclin dependent kinase inhibitor 1A	Homo sapiens	74-77
25070648-5	2014	Furthermore, western blot analysis revealed that curcumin induced p53 and p21(WAF1/CIP1) expression with a concomitant decrease in proliferating cell nuclear antigen protein levels (P&lt;0.05).	Curcumin	49-57	cyclin dependent kinase inhibitor 1A	Homo sapiens	78-82
25070648-5	2014	Furthermore, western blot analysis revealed that curcumin induced p53 and p21(WAF1/CIP1) expression with a concomitant decrease in proliferating cell nuclear antigen protein levels (P&lt;0.05).	Curcumin	49-57	cyclin dependent kinase inhibitor 1A	Homo sapiens	83-87
25070648-6	2014	Curcumin effectively inhibited primary hRPE cell proliferation, which may be mediated by the p53 pathway.	Curcumin	0-8	tumor protein p53	Homo sapiens	93-96
25050915-0	2014	Curcumin sensitizes glioblastoma to temozolomide by simultaneously generating ROS and disrupting AKT/mTOR signaling.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	97-100
25050915-0	2014	Curcumin sensitizes glioblastoma to temozolomide by simultaneously generating ROS and disrupting AKT/mTOR signaling.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	101-105
24706026-3	2014	It also has been proved the antineoplastic effect of curcumin through down-regulating Notch1 receptor and its downstream nuclear transcription factor NF-kappaB levels.	Curcumin	53-61	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	150-159
25251395-6	2014	Selective gut decontamination and supplementation with curcumin significantly attenuated the WD-induced increase in plasma LPS levels (3.32 vs 1.90 or 1.51 EU/ml, respectively) and improved intestinal barrier function at multiple levels (restoring intestinal alkaline phosphatase activity and expression of tight junction proteins, ZO-1 and Claudin-1).	Curcumin	55-63	toll-like receptor 4	Mus musculus	123-126
24831732-0	2014	Curcumin modulates miR-19/PTEN/AKT/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferation.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	31-34
24831732-0	2014	Curcumin modulates miR-19/PTEN/AKT/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferation.	Curcumin	0-8	tumor protein p53	Homo sapiens	35-38
24831732-8	2014	These results suggest for the first time that curcumin modulates miR-19/PTEN/AKT/p53 axis to exhibit its protective effects against BPA-associated breast cancer promotion.	Curcumin	46-54	AKT serine/threonine kinase 1	Homo sapiens	77-80
24831732-8	2014	These results suggest for the first time that curcumin modulates miR-19/PTEN/AKT/p53 axis to exhibit its protective effects against BPA-associated breast cancer promotion.	Curcumin	46-54	tumor protein p53	Homo sapiens	81-84
25338570-9	2014	Arsenic trioxide combined with curcumin can effectively inhibit the KG1a cell proliferation and induce apoptosis, which may be associated with the downregulation of BCL-2 and PARP protein expression and the upregulation of BAX protein expression.	Curcumin	31-39	BCL2 apoptosis regulator	Homo sapiens	165-170
25338570-9	2014	Arsenic trioxide combined with curcumin can effectively inhibit the KG1a cell proliferation and induce apoptosis, which may be associated with the downregulation of BCL-2 and PARP protein expression and the upregulation of BAX protein expression.	Curcumin	31-39	BCL2 associated X, apoptosis regulator	Homo sapiens	223-226
25251395-6	2014	Selective gut decontamination and supplementation with curcumin significantly attenuated the WD-induced increase in plasma LPS levels (3.32 vs 1.90 or 1.51 EU/ml, respectively) and improved intestinal barrier function at multiple levels (restoring intestinal alkaline phosphatase activity and expression of tight junction proteins, ZO-1 and Claudin-1).	Curcumin	55-63	tight junction protein 1	Mus musculus	332-336
25226537-8	2014	In addition, Mapk1 (ERK) and Mapk14 (MAPK p38) had more cross-interactions with other genes and revealed an increase in expression by 8.14- and 11.84-fold, respectively during the combinatorial treatment by curcumin and MMC when compared with the control.	Curcumin	207-215	mitogen-activated protein kinase 1	Homo sapiens	13-18
25241044-0	2014	Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	60-64
25241044-0	2014	Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages.	Curcumin	0-8	proline rich transmembrane protein 2	Homo sapiens	69-72
25241044-4	2014	The purpose of our study was to investigate the molecular mechanisms by which curcumin affects MMP-9, MMP13 and EMMPRIN in PMA (phorbol 12-myristate 13-acetate) induced macrophages.	Curcumin	78-86	matrix metallopeptidase 13	Homo sapiens	102-107
25241044-6	2014	In the present study, the exposure to curcumin resulted in attenuated JNK, p38, and ERK activation and decreased expression of MMP-9, MMP-13 and EMMPRIN in PMA induced macrophages.	Curcumin	38-46	mitogen-activated protein kinase 14	Homo sapiens	75-78
25241044-6	2014	In the present study, the exposure to curcumin resulted in attenuated JNK, p38, and ERK activation and decreased expression of MMP-9, MMP-13 and EMMPRIN in PMA induced macrophages.	Curcumin	38-46	mitogen-activated protein kinase 1	Homo sapiens	84-87
25241044-6	2014	In the present study, the exposure to curcumin resulted in attenuated JNK, p38, and ERK activation and decreased expression of MMP-9, MMP-13 and EMMPRIN in PMA induced macrophages.	Curcumin	38-46	matrix metallopeptidase 13	Homo sapiens	134-140
25241044-8	2014	Furthermore, curcumin reversed PMA stimulated PKC activation and suppressed the chronic activation of AMPK, which in turn reduced the expression of MMP-9, MMP-13 and EMMPRIN.	Curcumin	13-21	proline rich transmembrane protein 2	Homo sapiens	46-49
25241044-8	2014	Furthermore, curcumin reversed PMA stimulated PKC activation and suppressed the chronic activation of AMPK, which in turn reduced the expression of MMP-9, MMP-13 and EMMPRIN.	Curcumin	13-21	matrix metallopeptidase 13	Homo sapiens	155-161
25241044-9	2014	Therefore, it is suggested that curcumin by inhibiting AMPK-MAPK (mitogen activated protein kinase) and PKC pathway may led to down-regulated EMMPRIN, MMP-9 and MMP-13 expression in PMA-induced THP-1 cells.	Curcumin	32-40	mitogen-activated protein kinase 1	Homo sapiens	60-64
25241044-9	2014	Therefore, it is suggested that curcumin by inhibiting AMPK-MAPK (mitogen activated protein kinase) and PKC pathway may led to down-regulated EMMPRIN, MMP-9 and MMP-13 expression in PMA-induced THP-1 cells.	Curcumin	32-40	proline rich transmembrane protein 2	Homo sapiens	104-107
25241044-9	2014	Therefore, it is suggested that curcumin by inhibiting AMPK-MAPK (mitogen activated protein kinase) and PKC pathway may led to down-regulated EMMPRIN, MMP-9 and MMP-13 expression in PMA-induced THP-1 cells.	Curcumin	32-40	matrix metallopeptidase 13	Homo sapiens	161-167
25400722-0	2014	Curcumin inhibits oral squamous cell carcinoma proliferation and invasion via EGFR signaling pathways.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	78-82
25400722-2	2014	Curcumin is known to inhibit growth, invasion and metastasis by downregulating EGFR expression in some cancer cells.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	79-83
25400722-5	2014	We also explored the effect of curcumin on the activition of EGFR and its downstream signaling molecules Akt, ERK1/2 and STAT3.	Curcumin	31-39	epidermal growth factor receptor	Homo sapiens	61-65
25400722-5	2014	We also explored the effect of curcumin on the activition of EGFR and its downstream signaling molecules Akt, ERK1/2 and STAT3.	Curcumin	31-39	AKT serine/threonine kinase 1	Homo sapiens	105-108
25226537-8	2014	In addition, Mapk1 (ERK) and Mapk14 (MAPK p38) had more cross-interactions with other genes and revealed an increase in expression by 8.14- and 11.84-fold, respectively during the combinatorial treatment by curcumin and MMC when compared with the control.	Curcumin	207-215	mitogen-activated protein kinase 1	Homo sapiens	20-23
25226537-8	2014	In addition, Mapk1 (ERK) and Mapk14 (MAPK p38) had more cross-interactions with other genes and revealed an increase in expression by 8.14- and 11.84-fold, respectively during the combinatorial treatment by curcumin and MMC when compared with the control.	Curcumin	207-215	mitogen-activated protein kinase 14	Homo sapiens	29-35
25400722-6	2014	Furthermore, we examined the inhibition effect of curcumin on EGF-induced EGFR phosphorylation and SCC-25 cells invasion.	Curcumin	50-58	epidermal growth factor receptor	Homo sapiens	74-78
25226537-11	2014	The synergistic effect of combinatorial treatment by curcumin and MMC on the induction of apoptosis in breast cancer cells may be via the ERK pathway.	Curcumin	53-61	mitogen-activated protein kinase 1	Homo sapiens	138-141
24857031-10	2014	Taken together, the present study unveils rutin and curcumin as a possible effective stimulation for fatty acid-induced autophagy via mTOR-dependent pathways in NHSC.	Curcumin	52-60	mechanistic target of rapamycin kinase	Homo sapiens	134-138
25400722-8	2014	Curcumin also inhibited SCC-25 cells invasion and downregulated MMP-2, MMP-9, uPA and uPAR expression.	Curcumin	0-8	proline rich acidic protein 1	Homo sapiens	78-81
25400722-9	2014	We further revealed that curcumin regulated the p-EGFR and EGFR downstream signaling molecules including Akt, ERK1/2 and STAT3.	Curcumin	25-33	epidermal growth factor receptor	Homo sapiens	50-54
25400722-9	2014	We further revealed that curcumin regulated the p-EGFR and EGFR downstream signaling molecules including Akt, ERK1/2 and STAT3.	Curcumin	25-33	epidermal growth factor receptor	Homo sapiens	59-63
25400722-9	2014	We further revealed that curcumin regulated the p-EGFR and EGFR downstream signaling molecules including Akt, ERK1/2 and STAT3.	Curcumin	25-33	AKT serine/threonine kinase 1	Homo sapiens	105-108
25400722-9	2014	We further revealed that curcumin regulated the p-EGFR and EGFR downstream signaling molecules including Akt, ERK1/2 and STAT3.	Curcumin	25-33	mitogen-activated protein kinase 3	Homo sapiens	110-116
25400722-9	2014	We further revealed that curcumin regulated the p-EGFR and EGFR downstream signaling molecules including Akt, ERK1/2 and STAT3.	Curcumin	25-33	signal transducer and activator of transcription 3	Homo sapiens	121-126
25400722-11	2014	Taken together, our results suggest that curcumin reduced SCC-25 cells proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3.	Curcumin	41-49	epidermal growth factor receptor	Homo sapiens	140-144
25400722-11	2014	Taken together, our results suggest that curcumin reduced SCC-25 cells proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3.	Curcumin	41-49	epidermal growth factor receptor	Homo sapiens	149-153
25400722-11	2014	Taken together, our results suggest that curcumin reduced SCC-25 cells proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3.	Curcumin	41-49	AKT serine/threonine kinase 1	Homo sapiens	185-188
25400722-11	2014	Taken together, our results suggest that curcumin reduced SCC-25 cells proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3.	Curcumin	41-49	mitogen-activated protein kinase 3	Homo sapiens	190-196
25400722-11	2014	Taken together, our results suggest that curcumin reduced SCC-25 cells proliferation and invasion through inhibiting the phosphorylation of EGFR and EGFR downstream signaling molecules Akt, ERK1/2 and STAT3.	Curcumin	41-49	signal transducer and activator of transcription 3	Homo sapiens	201-206
25088002-8	2014	Pretreatment with curcumin, an inhibitor of JAK2 and p300, blocked Ang II-induced effects.	Curcumin	18-26	angiotensinogen	Rattus norvegicus	67-73
24998635-7	2014	We found that curcumin decreased the release of IL-6 and reduced MMP-9 enzyme activity.	Curcumin	14-22	interleukin 6	Homo sapiens	48-52
25229239-12	2014	It was found that curcumin attenuated AKT activation and the up-regulation of C/EBPbeta and miR-31 caused by EGF stimulation in OSCC cells.	Curcumin	18-26	AKT serine/threonine kinase 1	Homo sapiens	38-41
25198898-0	2014	Curcumin induced human gastric cancer BGC-823 cells apoptosis by ROS-mediated ASK1-MKK4-JNK stress signaling pathway.	Curcumin	0-8	mitogen-activated protein kinase kinase 4	Homo sapiens	83-87
25198898-0	2014	Curcumin induced human gastric cancer BGC-823 cells apoptosis by ROS-mediated ASK1-MKK4-JNK stress signaling pathway.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	88-91
25198898-5	2014	Notably, we observed that curcumin activated ASK1, a MAPKKK that is oxidative stress sensitive and responsible to phosphorylation of JNK via triggering cascades, up-regulated an upstream effector of the JNK, MKK4, and phosphorylated JNK protein expression in BGC-823 cells.	Curcumin	26-34	mitogen-activated protein kinase 8	Homo sapiens	133-136
25198898-5	2014	Notably, we observed that curcumin activated ASK1, a MAPKKK that is oxidative stress sensitive and responsible to phosphorylation of JNK via triggering cascades, up-regulated an upstream effector of the JNK, MKK4, and phosphorylated JNK protein expression in BGC-823 cells.	Curcumin	26-34	mitogen-activated protein kinase 8	Homo sapiens	203-206
25198898-5	2014	Notably, we observed that curcumin activated ASK1, a MAPKKK that is oxidative stress sensitive and responsible to phosphorylation of JNK via triggering cascades, up-regulated an upstream effector of the JNK, MKK4, and phosphorylated JNK protein expression in BGC-823 cells.	Curcumin	26-34	mitogen-activated protein kinase kinase 4	Homo sapiens	208-212
25198898-5	2014	Notably, we observed that curcumin activated ASK1, a MAPKKK that is oxidative stress sensitive and responsible to phosphorylation of JNK via triggering cascades, up-regulated an upstream effector of the JNK, MKK4, and phosphorylated JNK protein expression in BGC-823 cells.	Curcumin	26-34	mitogen-activated protein kinase 8	Homo sapiens	203-206
25198898-6	2014	However, curcumin induced ASK1-MKK4-JNK signaling was attenuated by NAC.	Curcumin	9-17	mitogen-activated protein kinase kinase 4	Homo sapiens	31-35
25198898-6	2014	However, curcumin induced ASK1-MKK4-JNK signaling was attenuated by NAC.	Curcumin	9-17	mitogen-activated protein kinase 8	Homo sapiens	36-39
25198898-7	2014	All the findings confirm the possibility that oxidative stress-activated ASK1-MKK4-JNK signaling cascade promotes the apoptotic response in curcumin-treated BGC-823 cells.	Curcumin	140-148	mitogen-activated protein kinase kinase 4	Homo sapiens	78-82
25198898-7	2014	All the findings confirm the possibility that oxidative stress-activated ASK1-MKK4-JNK signaling cascade promotes the apoptotic response in curcumin-treated BGC-823 cells.	Curcumin	140-148	mitogen-activated protein kinase 8	Homo sapiens	83-86
27122821-5	2014	Compared to those without curcumin, curcumin-treated cardiac fibroblasts exhibited lower migratory, proliferative abilities and collagen production at the baseline and after the co-administration of TGF-beta1 or Ang II.	Curcumin	36-44	transforming growth factor, beta 1	Rattus norvegicus	199-208
27122821-5	2014	Compared to those without curcumin, curcumin-treated cardiac fibroblasts exhibited lower migratory, proliferative abilities and collagen production at the baseline and after the co-administration of TGF-beta1 or Ang II.	Curcumin	36-44	angiotensinogen	Rattus norvegicus	212-218
27122821-6	2014	Curcumin-treated cardiac fibroblasts had increased matrix metalloproteinase (MMP)-2 activity in the presence of Ang II treatment.	Curcumin	0-8	angiotensinogen	Rattus norvegicus	112-118
27122821-7	2014	Curcumin-treated cardiac fibroblasts down-regulated phosphorylated protein kinase B (Akt) and phosphorylated Smad2/3 expression irrespective of TGF-beta1 treatment.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	85-88
27122821-8	2014	Curcumin also decreased phosphorylated extracellular signal-regulated kinase (ERK)1/2 levels in the presence of Ang II.	Curcumin	0-8	angiotensinogen	Rattus norvegicus	112-118
27122821-9	2014	CONCLUSIONS: Curcumin attenuated Akt, Smad2/3, and ERK1/2 phosphorylation which were mediated by TGF-beta1 and angiotensin II.	Curcumin	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	33-36
27122821-9	2014	CONCLUSIONS: Curcumin attenuated Akt, Smad2/3, and ERK1/2 phosphorylation which were mediated by TGF-beta1 and angiotensin II.	Curcumin	13-21	transforming growth factor, beta 1	Rattus norvegicus	97-106
27122821-9	2014	CONCLUSIONS: Curcumin attenuated Akt, Smad2/3, and ERK1/2 phosphorylation which were mediated by TGF-beta1 and angiotensin II.	Curcumin	13-21	angiotensinogen	Rattus norvegicus	111-125
24914461-9	2014	Taken together, our results indicate that the antidepressant-like effects of curcumin in CUS rats are related to its aptitude to promote BDNF and ERK in the hippocampus.	Curcumin	77-85	Eph receptor B1	Rattus norvegicus	146-149
25060817-0	2014	Curcumin analogues with high activity for inhibiting human prostate cancer cell growth and androgen receptor activation.	Curcumin	0-8	androgen receptor	Homo sapiens	91-108
24486718-0	2014	Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
25060817-7	2014	The results indicate that one of the potential mechanisms for the anticancer effect of the curcumin analogues was inhibition of AR pathways in human prostate cancer cells.	Curcumin	91-99	androgen receptor	Homo sapiens	128-130
24998672-8	2014	The limit of detection (LOD) for gemcitabine and curcumin was 0.04muM and 0.03muM, respectively.	Curcumin	49-57	latexin	Homo sapiens	66-69
24651933-0	2014	Curcumin attenuates ischemia-like injury induced IL-1beta elevation in brain microvascular endothelial cells via inhibiting MAPK pathways and nuclear factor-kappaB activation.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	49-57
24486718-4	2014	Curcumin can induce the expression of Nrf2 in both non-breast cancer cells and breast cancer cells.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
24486718-5	2014	However, whether curcumin-induced inhibition of breast cancer cell proliferation may involve Nrf2-mediated Fen1 expression is not yet understood.	Curcumin	17-25	NFE2 like bZIP transcription factor 2	Homo sapiens	93-97
24486718-6	2014	In this study, we demonstrated that curcumin inhibited Fen1-dependent proliferation of MCF-7 cells and significantly induced Nrf2 protein expression while inhibiting Fen1 protein expression.	Curcumin	36-44	NFE2 like bZIP transcription factor 2	Homo sapiens	125-129
24486718-7	2014	Curcumin could down-regulate Fen1 gene expression in a Nrf2-dependent manner.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	55-59
24486718-8	2014	Further investigation revealed that curcumin could lead to Nrf2 translocation from the cytoplasm to the nucleus and decrease Fen1 promoter activity by decreasing the recruitment of Nrf2 to the Fen1 promoter.	Curcumin	36-44	NFE2 like bZIP transcription factor 2	Homo sapiens	59-63
24486718-8	2014	Further investigation revealed that curcumin could lead to Nrf2 translocation from the cytoplasm to the nucleus and decrease Fen1 promoter activity by decreasing the recruitment of Nrf2 to the Fen1 promoter.	Curcumin	36-44	NFE2 like bZIP transcription factor 2	Homo sapiens	181-185
24486718-9	2014	These data suggest that curcumin may inhibit the proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression, which may be a new mechanism of curcumin-induced tumor growth inhibition.	Curcumin	24-32	NFE2 like bZIP transcription factor 2	Homo sapiens	94-98
24486718-9	2014	These data suggest that curcumin may inhibit the proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression, which may be a new mechanism of curcumin-induced tumor growth inhibition.	Curcumin	176-184	NFE2 like bZIP transcription factor 2	Homo sapiens	94-98
24651933-6	2014	The treatment of curcumin (20 muM) inhibited the increased production of IL-1beta both at the protein and mRNA levels.	Curcumin	17-25	interleukin 1 beta	Rattus norvegicus	73-81
24651933-7	2014	The increased phosphorylation of p38 and JNK induced by OGD was decreased under the treatment of curcumin, whereas the p38 inhibitor, SB203580, significantly inhibited OGD-induced IL-1beta production, but the JNK inhibitor, SP600125, failed to do so.	Curcumin	97-105	interleukin 1 beta	Rattus norvegicus	180-188
24651933-8	2014	These results suggest that the inhibition of IL-1beta by curcumin may dependent on the p38 signaling pathway.	Curcumin	57-65	interleukin 1 beta	Rattus norvegicus	45-53
25230870-16	2014	Mechanism of effect of curcumin on MPT may be related to reduction of intracellular calcium concentration, promotion of anti-apoptotic Bcl-2 gene expression, inhibition of caspase-3 activation and Bax gene.	Curcumin	23-31	BCL2, apoptosis regulator	Rattus norvegicus	135-140
25091588-0	2014	Recombinant IkappaBalpha-loaded curcumin nanoparticles for improved cancer therapeutics.	Curcumin	32-40	NFKB inhibitor alpha	Homo sapiens	12-24
25091588-5	2014	Another similar naturally available molecule, which inhibits the function of NFkappaB, is curcumin.	Curcumin	90-98	nuclear factor kappa B subunit 1	Homo sapiens	77-85
25091588-6	2014	Hence, we have developed a "green synthesis" method for preparing water-soluble curcumin nanoparticles to stabilize recombinant IkappaBalpha protein.	Curcumin	80-88	NFKB inhibitor alpha	Homo sapiens	128-140
25091588-10	2014	Thus, our study revealed that the functional delivery of recombinant IkappaBalpha-loaded curcumin NPs has promise as a natural-product-based protein therapeutics against cancer cells.	Curcumin	89-97	NFKB inhibitor alpha	Homo sapiens	69-81
25170806-0	2014	Curcumin promotes KLF5 proteasome degradation through downregulating YAP/TAZ in bladder cancer cells.	Curcumin	0-8	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	73-76
25170806-4	2014	Furthermore, we found that curcumin could down-regulate the expression of Hippo pathway effectors, YAP and TAZ, which have been reported to protect KLF5 protein from degradation.	Curcumin	27-35	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	107-110
25170806-7	2014	Thus, our data indicates that curcumin promotes KLF5 proteasome-dependent degradation through targeting YAP/TAZ in bladder cancer cells and also suggests the therapeutic potential of curcumin in the treatment of bladder cancer.	Curcumin	30-38	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	108-111
25088288-4	2014	RESULTS: Curcumin reduced HCMV immediate early antigen (IEA) and UL83A expressions and IL-6, and TNF-alpha secretions and recovered cell proliferation to normal level in HCMV infected HELF cells.	Curcumin	9-17	interleukin 6	Homo sapiens	87-91
24910117-5	2014	Western blot assay data demonstrated that curcumin inhibited phosphorylation of PI3K and Akt signaling pathways and subsequently attenuated MMP1/7 and COX-2 protein expressions in FTC133.	Curcumin	42-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	151-156
25296502-3	2014	We found that such conjugation significantly increased the uptake of curcumin in various cancer cells and caused cancer cell death by inducing apoptosis by decreasing the phosphorylation of Akt1 (Thr308) and STAT3 (Tyr705).	Curcumin	69-77	AKT serine/threonine kinase 1	Homo sapiens	190-194
25089037-4	2014	Knowing that curcumin has been used as food to inhibit cancer activity, this study evaluated the efficacy of natural curcumins and curcumin analogs as HER2 inhibitors using in vitro and in silico studies.	Curcumin	117-126	erb-b2 receptor tyrosine kinase 2	Homo sapiens	151-155
24318305-0	2014	Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling.	Curcumin	39-47	epidermal growth factor receptor	Homo sapiens	115-119
24318305-3	2014	Treatment of MCF-7 cell lines with paclitaxel and curcumin induced the apoptosis of regulatory protein Bcl-2 but decreased Bax expression.	Curcumin	50-58	BCL2 apoptosis regulator	Homo sapiens	103-108
24318305-3	2014	Treatment of MCF-7 cell lines with paclitaxel and curcumin induced the apoptosis of regulatory protein Bcl-2 but decreased Bax expression.	Curcumin	50-58	BCL2 associated X, apoptosis regulator	Homo sapiens	123-126
24318305-4	2014	In addition, simultaneous treatment with paclitaxel and curcumin strongly inhibited paclitaxel-induced activities of EGFR signaling.	Curcumin	56-64	epidermal growth factor receptor	Homo sapiens	117-121
24866129-6	2014	Molecular modelling suggests that curcumin, resveratrol and nicotinamide all bind over the isoalloxazine ring of the FMN cofactor in Lot6p.	Curcumin	34-42	flavin-dependent quinone reductase	Saccharomyces cerevisiae S288C	133-138
24961640-2	2014	In the lactate dehydrogenase (LDH) release assay involving co-treatment with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and/or synthetic curcumin derivatives using TRAIL-resistant human CRT-MG astroglioma cells, the novel curcumin mimic library was found to effectively stimulate the cytotoxicity of TRAIL, causing mild cytotoxicity when administered alone.	Curcumin	164-172	TNF superfamily member 10	Homo sapiens	191-196
24961640-2	2014	In the lactate dehydrogenase (LDH) release assay involving co-treatment with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and/or synthetic curcumin derivatives using TRAIL-resistant human CRT-MG astroglioma cells, the novel curcumin mimic library was found to effectively stimulate the cytotoxicity of TRAIL, causing mild cytotoxicity when administered alone.	Curcumin	164-172	TNF superfamily member 10	Homo sapiens	191-196
25136316-7	2014	In addition, curcumin with its versatile activities modulated the expression of many oxidative stress-regulating genes such as PDGF, VEGF, IGFBP-2, HO1, SOD2, and GPX1.	Curcumin	13-21	vascular endothelial growth factor A	Homo sapiens	133-137
24142484-4	2014	Expression of exogenous p50 and p65 subunits of NF-kappaB conferred partial protection on transfected GL261 cells against curcumin insult, indicating that NF-kappaB played a key role in protecting glioblastoma cells.	Curcumin	122-130	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	24-27
24142484-4	2014	Expression of exogenous p50 and p65 subunits of NF-kappaB conferred partial protection on transfected GL261 cells against curcumin insult, indicating that NF-kappaB played a key role in protecting glioblastoma cells.	Curcumin	122-130	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	48-57
24142484-4	2014	Expression of exogenous p50 and p65 subunits of NF-kappaB conferred partial protection on transfected GL261 cells against curcumin insult, indicating that NF-kappaB played a key role in protecting glioblastoma cells.	Curcumin	122-130	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	155-164
25296502-3	2014	We found that such conjugation significantly increased the uptake of curcumin in various cancer cells and caused cancer cell death by inducing apoptosis by decreasing the phosphorylation of Akt1 (Thr308) and STAT3 (Tyr705).	Curcumin	69-77	signal transducer and activator of transcription 3	Homo sapiens	208-213
25296502-4	2014	In this study, a molecular mechanistic model deciphering the regulation of phosphorylation of Akt1 and STAT3 by mitocurcumin-1 was investigated and compared with curcumin.	Curcumin	116-124	AKT serine/threonine kinase 1	Homo sapiens	94-98
25296502-4	2014	In this study, a molecular mechanistic model deciphering the regulation of phosphorylation of Akt1 and STAT3 by mitocurcumin-1 was investigated and compared with curcumin.	Curcumin	116-124	signal transducer and activator of transcription 3	Homo sapiens	103-108
25031079-0	2014	Study of interaction of human serum albumin with curcumin by NMR and docking.	Curcumin	49-57	albumin	Homo sapiens	30-43
24814288-10	2014	In addition, cell viability and drug pump-out ability were significantly reduced in the FZD1 inhibitor curcumin-treated and FZD1 shRNA-knockdown MES-SA/Dx5 cells, indicating involvement of PKCdelta in FZD1-modulated ABCB1 expression pathway.	Curcumin	103-111	ATP binding cassette subfamily B member 1	Homo sapiens	216-221
24863870-7	2014	Curcumin showed significant cardiac protection with improvement of redox status, mitochondrial function, 8-OHdG level, caspase-3 immunoreactivity, and cardiac muscle degeneration.	Curcumin	0-8	caspase 3	Homo sapiens	119-128
24863870-8	2014	From this current study, it can be concluded that administration of curcumin improved atrazine-induced cardiotoxicity through its modulatory effect on redox status, mitochondrial function, and caspase-3 expression.	Curcumin	68-76	caspase 3	Homo sapiens	193-202
25031079-6	2014	We report that curcumin has shown comparable binding affinity value vis-a-vis standard, the accessible surface area (ASA) of human serum albumin (uncomplexed) and its docked complex with curcumin at both binding sites was calculated and found to be close to that of warfarin and diazepam respectively.	Curcumin	15-23	albumin	Homo sapiens	131-144
25031079-6	2014	We report that curcumin has shown comparable binding affinity value vis-a-vis standard, the accessible surface area (ASA) of human serum albumin (uncomplexed) and its docked complex with curcumin at both binding sites was calculated and found to be close to that of warfarin and diazepam respectively.	Curcumin	187-195	albumin	Homo sapiens	131-144
24835302-4	2014	H1975 NSCLC cells were treated with curcumin (0-50 muM) alone, or combined with gemcitabine or cisplatin.	Curcumin	36-44	latexin	Homo sapiens	51-54
24522815-0	2014	Transferrin-targeted polymeric micelles co-loaded with curcumin and paclitaxel: efficient killing of paclitaxel-resistant cancer cells.	Curcumin	55-63	transferrin	Homo sapiens	0-11
24899159-14	2014	These results suggested that curcumin protects against D-GalN/LPS-induced liver damage by the enhancing antioxidant defense system, attenuating mitochondrial dysfunction and inhibiting apoptosis.	Curcumin	29-37	galanin and GMAP prepropeptide	Mus musculus	57-61
24522815-3	2014	In this study, the therapeutic potential of transferrin (TF)-targeted mixed micelles, made of PEG-PE and vitamin E co-loaded with curcumin (CUR), a potent NF-kappaB inhibitor, and paclitaxel (PCL), was examined.	Curcumin	130-138	transferrin	Homo sapiens	44-55
24522815-3	2014	In this study, the therapeutic potential of transferrin (TF)-targeted mixed micelles, made of PEG-PE and vitamin E co-loaded with curcumin (CUR), a potent NF-kappaB inhibitor, and paclitaxel (PCL), was examined.	Curcumin	130-138	transferrin	Homo sapiens	57-59
24668546-6	2014	Elucidation of the molecular mechanism of curcumin on TGF-beta signaling pathway-induced colon carcinogenesis may ultimately lead to novel and more effective treatments for colon cancer.	Curcumin	42-50	transforming growth factor beta 1	Homo sapiens	54-62
24725345-1	2014	We have previously shown that curcumin (CUR) may increase lipid accumulation in cultured human acute monocytic leukaemia cell line THP-1 monocytes/macrophages, but that tetrahydrocurcumin (THC), an in vivo metabolite of CUR, has no such effect.	Curcumin	30-38	GLI family zinc finger 2	Homo sapiens	131-136
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	Curcumin	79-87	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	252-282
24756894-0	2014	Curcumin inhibits the AKT/NF-kappaB signaling via CpG demethylation of the promoter and restoration of NEP in the N2a cell line.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	22-25
24756894-0	2014	Curcumin inhibits the AKT/NF-kappaB signaling via CpG demethylation of the promoter and restoration of NEP in the N2a cell line.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	26-35
24751969-7	2014	The preventive effect of curcumin on the noxious effects induced by heavy metals has been attributed to its scavenging and chelating properties, and/or to the ability to induce the Nrf2/Keap1/ARE pathway.	Curcumin	25-33	NFE2 like bZIP transcription factor 2	Homo sapiens	181-185
24751969-7	2014	The preventive effect of curcumin on the noxious effects induced by heavy metals has been attributed to its scavenging and chelating properties, and/or to the ability to induce the Nrf2/Keap1/ARE pathway.	Curcumin	25-33	kelch like ECH associated protein 1	Homo sapiens	186-191
24785678-0	2014	Curcumin abolishes mutant TDP-43 induced excitability in a motoneuron-like cellular model of ALS.	Curcumin	0-8	TAR DNA binding protein	Homo sapiens	26-32
24628444-8	2014	Curcumin modulates the T lymphocyte response impairing proliferation and interferon (IFN)-gamma production through modulation of T-box expressed in T cells (T-bet), a key transcription factor for proinflammatory T helper type 1 (Th1) lymphocyte differentiation, both at the transcriptional and translational levels.	Curcumin	0-8	interferon gamma	Mus musculus	73-95
24944632-6	2014	In conclusion, these results indicated that co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression of ApoAI, CYP7A1, LCAT and LDLR, providing a promising combination for the treatment of HLP.	Curcumin	65-73	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	201-207
24944632-6	2014	In conclusion, these results indicated that co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression of ApoAI, CYP7A1, LCAT and LDLR, providing a promising combination for the treatment of HLP.	Curcumin	65-73	low density lipoprotein receptor	Rattus norvegicus	218-222
24944632-6	2014	In conclusion, these results indicated that co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression of ApoAI, CYP7A1, LCAT and LDLR, providing a promising combination for the treatment of HLP.	Curcumin	135-143	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	201-207
24944632-6	2014	In conclusion, these results indicated that co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression of ApoAI, CYP7A1, LCAT and LDLR, providing a promising combination for the treatment of HLP.	Curcumin	135-143	low density lipoprotein receptor	Rattus norvegicus	218-222
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	Curcumin	79-87	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	284-290
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	Curcumin	79-87	low density lipoprotein receptor	Rattus norvegicus	296-328
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	Curcumin	79-87	low density lipoprotein receptor	Rattus norvegicus	330-334
24746751-5	2014	Intranasal curcumin administration prevented accumulation of inflammatory cells to the airways, structural alterations and remodeling associated with chronic asthma like peribronchial and airway smooth muscle thickening, sloughing off of the epithelial lining and mucus secretion in ovalbumin induced murine model of chronic asthma.	Curcumin	11-19	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	283-292
24680995-7	2014	We found that curcumin prevented ICH-induced inflammatory molecules through NF-kappaB activation via the p38MAPK/PKC pathway in vitro.	Curcumin	14-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-85
24779927-7	2014	Further investigations showed that curcumin inhibited VEGF expression in HSCs associated with disrupting platelet-derived growth factor-beta receptor (PDGF-betaR)/ERK and mTOR pathways.	Curcumin	35-43	Eph receptor B1	Rattus norvegicus	163-166
24819716-3	2014	FLLL31 is a newly developed compound based on the herbal medicine curcumin, which specifically suppresses the activation of STAT3.	Curcumin	66-74	signal transducer and activator of transcription 3	Mus musculus	124-129
24806432-0	2014	Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin.	Curcumin	173-181	forkhead box O3	Homo sapiens	86-92
24806432-0	2014	Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin.	Curcumin	173-181	tumor protein p53	Homo sapiens	97-100
25289117-7	2014	Also, curcumin stimulates proliferation of SC-NPCs via the MAP kinase signaling pathway, especially involving the p-ERK and p-38 protein.	Curcumin	6-14	Eph receptor B1	Rattus norvegicus	116-119
25289117-8	2014	The p-ERK protein and p38 protein levels varied depending on curcumin dosage (0.5 and 1 microM, p&lt;0.05).	Curcumin	61-69	Eph receptor B1	Rattus norvegicus	6-9
23024111-11	2014	Accordingly, this study suggests that the reduction in oxidative stress and modulation of HO-1 mRNA expression and TNF-alpha release by curcumin and quercetin may contribute to the synergistic anti-inflammatory effects of these two flavonoids upon combination.	Curcumin	136-144	tumor necrosis factor	Rattus norvegicus	115-124
24806432-4	2014	To further explore the potential mechanism, we showed that curcumin increased the phosphorylation of ERK1/2 but not p38 MAPK in a time-dependent manner, and induced protein expression of the tumor suppressors FOXO3a and p53 in a dose-dependent manner, which were not observed in the presence of PD98059, an inhibitor of ERK1/2.	Curcumin	59-67	mitogen-activated protein kinase 3	Homo sapiens	101-107
24806432-4	2014	To further explore the potential mechanism, we showed that curcumin increased the phosphorylation of ERK1/2 but not p38 MAPK in a time-dependent manner, and induced protein expression of the tumor suppressors FOXO3a and p53 in a dose-dependent manner, which were not observed in the presence of PD98059, an inhibitor of ERK1/2.	Curcumin	59-67	forkhead box O3	Homo sapiens	209-215
24806432-4	2014	To further explore the potential mechanism, we showed that curcumin increased the phosphorylation of ERK1/2 but not p38 MAPK in a time-dependent manner, and induced protein expression of the tumor suppressors FOXO3a and p53 in a dose-dependent manner, which were not observed in the presence of PD98059, an inhibitor of ERK1/2.	Curcumin	59-67	tumor protein p53	Homo sapiens	220-223
24806432-4	2014	To further explore the potential mechanism, we showed that curcumin increased the phosphorylation of ERK1/2 but not p38 MAPK in a time-dependent manner, and induced protein expression of the tumor suppressors FOXO3a and p53 in a dose-dependent manner, which were not observed in the presence of PD98059, an inhibitor of ERK1/2.	Curcumin	59-67	mitogen-activated protein kinase 3	Homo sapiens	320-326
24806432-5	2014	Furthermore, silencing of FOXO3a and p53 genes by siRNAs overcame the inhibitory effect of curcumin on cell proliferation.	Curcumin	91-99	forkhead box O3	Homo sapiens	26-32
24806432-5	2014	Furthermore, silencing of FOXO3a and p53 genes by siRNAs overcame the inhibitory effect of curcumin on cell proliferation.	Curcumin	91-99	tumor protein p53	Homo sapiens	37-40
24806432-6	2014	Silencing or blockade of p53 using siRNA or chemical inhibitor abrogated the effect of curcumin on expression of FOXO3a protein; silencing or overexpression of FOXO3a had no further effect on curcumin-induced p53 protein expression.	Curcumin	87-95	tumor protein p53	Homo sapiens	25-28
24806432-6	2014	Silencing or blockade of p53 using siRNA or chemical inhibitor abrogated the effect of curcumin on expression of FOXO3a protein; silencing or overexpression of FOXO3a had no further effect on curcumin-induced p53 protein expression.	Curcumin	87-95	forkhead box O3	Homo sapiens	113-119
24806432-7	2014	Furthermore, blockade of ERK1/2 and exogenous expression of FOXO3a restored the effect of curcumin on growth of cells.	Curcumin	90-98	mitogen-activated protein kinase 3	Homo sapiens	25-31
24806432-7	2014	Furthermore, blockade of ERK1/2 and exogenous expression of FOXO3a restored the effect of curcumin on growth of cells.	Curcumin	90-98	forkhead box O3	Homo sapiens	60-66
24806432-8	2014	Together, our studies show that curcumin inhibits growth and induces apoptosis of NPC cells through ERK1/2-mediated increase in the protein expression and interaction of p53 and FOXO3a.	Curcumin	32-40	mitogen-activated protein kinase 3	Homo sapiens	100-106
24806432-8	2014	Together, our studies show that curcumin inhibits growth and induces apoptosis of NPC cells through ERK1/2-mediated increase in the protein expression and interaction of p53 and FOXO3a.	Curcumin	32-40	tumor protein p53	Homo sapiens	170-173
24806432-8	2014	Together, our studies show that curcumin inhibits growth and induces apoptosis of NPC cells through ERK1/2-mediated increase in the protein expression and interaction of p53 and FOXO3a.	Curcumin	32-40	forkhead box O3	Homo sapiens	178-184
24806432-9	2014	p53 is upstream of FOXO3a, which form a regulatory loop that mediates the effect of curcumin.	Curcumin	84-92	tumor protein p53	Homo sapiens	0-3
24806432-9	2014	p53 is upstream of FOXO3a, which form a regulatory loop that mediates the effect of curcumin.	Curcumin	84-92	forkhead box O3	Homo sapiens	19-25
24604727-6	2014	By regulating multiple important cellular signalling pathways including NF-kappaB, TRAIL, PI3 K/Akt, JAK/STAT, Notch-1, JNK, etc., curcumin are known to activate cell death signals and induce apoptosis in pre-cancerous or cancer cells without affecting normal cells, thereby inhibiting tumor progression.	Curcumin	131-139	notch receptor 1	Felis catus	111-118
24945581-0	2014	A PPARgamma, NF-kappaB and AMPK-dependent mechanism may be involved in the beneficial effects of curcumin in the diabetic db/db mice liver.	Curcumin	97-105	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	13-22
25061290-6	2014	Fluorescence-activated cell sorting (FACS) analysis using a human colon cancer cell line (HCT116) exhibited 99.1% fluorescence gating for 5 muM curcumin-loaded LCN dispersion compared to 1.36% for the same concentration of the drug in dimethyl sulfoxide (DMSO), indicating markedly enhanced cellular uptake.	Curcumin	144-152	latexin	Homo sapiens	140-143
24780320-8	2014	KEY FINDINGS: Exosomes derived from curcumin-treated (primed) cells (CUR-EXO) alleviated oxidative stress, tight junctions (ZO-1, claudin-5, occludin), adherent junction (VE-cadherin) proteins and EC layer permeability induced during EC damage due to high homocysteine levels (hyperhomocysteinemia).	Curcumin	36-44	tight junction protein 1	Mus musculus	124-128
24780320-8	2014	KEY FINDINGS: Exosomes derived from curcumin-treated (primed) cells (CUR-EXO) alleviated oxidative stress, tight junctions (ZO-1, claudin-5, occludin), adherent junction (VE-cadherin) proteins and EC layer permeability induced during EC damage due to high homocysteine levels (hyperhomocysteinemia).	Curcumin	36-44	occludin	Mus musculus	141-149
24780320-8	2014	KEY FINDINGS: Exosomes derived from curcumin-treated (primed) cells (CUR-EXO) alleviated oxidative stress, tight junctions (ZO-1, claudin-5, occludin), adherent junction (VE-cadherin) proteins and EC layer permeability induced during EC damage due to high homocysteine levels (hyperhomocysteinemia).	Curcumin	36-44	cadherin 5	Mus musculus	171-182
24945581-5	2014	Curcumin increased the expression of AMPK and PPARgamma, and diminished NF-kappaB protein in db/db mice.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	72-81
24945581-8	2014	In conclusion, curcumin regulates the expression of AMPK, PPARgamma, and NF-kappaB; suggesting a beneficial effect for treatment of T2DM complications.	Curcumin	15-23	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-82
24926361-8	2014	Curcumin also decreased ROS generation in TNF-alpha-stimulated VSMCs.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	42-51
24901233-5	2014	Curcumin is a substance which inhibits IL-1 signaling very early by preventing the recruitment of IL-1 receptor associated kinase (IRAK) to the IL-1 receptor.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	39-43
24901233-5	2014	Curcumin is a substance which inhibits IL-1 signaling very early by preventing the recruitment of IL-1 receptor associated kinase (IRAK) to the IL-1 receptor.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	98-102
24901233-6	2014	We demonstrate that IL-1 signaling and VEGF-A expression are blocked by Curcumin in chondrosarcoma cells.	Curcumin	72-80	interleukin 1 beta	Homo sapiens	20-24
24901233-6	2014	We demonstrate that IL-1 signaling and VEGF-A expression are blocked by Curcumin in chondrosarcoma cells.	Curcumin	72-80	vascular endothelial growth factor A	Homo sapiens	39-45
24901233-7	2014	We further show that Curcumin blocks IL-1beta-induced angiogenesis and NF-kappaB-related gene expression.	Curcumin	21-29	interleukin 1 beta	Homo sapiens	37-45
24901233-8	2014	We suppose that IL-1 blockade is an additional treatment option in chondrosarcoma, either by Curcumin, its derivatives or other IL-1 blocking agents.	Curcumin	93-101	interleukin 1 beta	Homo sapiens	16-20
24710058-2	2014	Here we investigated the effects of curcumin, a vegetal polyphenol with pleiotropic biological activity, because of its ability to upregulate glucose-regulated protein 94 kDa (Grp94) expression in myogenic cells.	Curcumin	36-44	heat shock protein 90 beta family member 1	Rattus norvegicus	142-174
24710058-2	2014	Here we investigated the effects of curcumin, a vegetal polyphenol with pleiotropic biological activity, because of its ability to upregulate glucose-regulated protein 94 kDa (Grp94) expression in myogenic cells.	Curcumin	36-44	heat shock protein 90 beta family member 1	Rattus norvegicus	176-181
24710058-5	2014	Curcumin administration increased Grp94 protein levels about twofold in muscles of ambulatory rats (P &lt; 0.05) and antagonized its decrease in unloaded ones.	Curcumin	0-8	heat shock protein 90 beta family member 1	Rattus norvegicus	34-39
24710058-8	2014	Mechanistic involvement of Grp94 was suggested by the disruption of curcumin-induced attenuation of myofibre atrophy after transfection with antisense grp94 cDNA and by the drug-positive effect on the maintenance of the subsarcolemmal localization of active neuronal nitric oxide synthase molecules, which were displaced to the sarcoplasm by unloading.	Curcumin	68-76	heat shock protein 90 beta family member 1	Rattus norvegicus	27-32
24710058-8	2014	Mechanistic involvement of Grp94 was suggested by the disruption of curcumin-induced attenuation of myofibre atrophy after transfection with antisense grp94 cDNA and by the drug-positive effect on the maintenance of the subsarcolemmal localization of active neuronal nitric oxide synthase molecules, which were displaced to the sarcoplasm by unloading.	Curcumin	68-76	heat shock protein 90 beta family member 1	Rattus norvegicus	151-156
24710058-10	2014	In conclusion, curcumin represents an effective and safe tool to upregulate Grp94 muscle levels and to maintain muscle function during unweighting.	Curcumin	15-23	heat shock protein 90 beta family member 1	Rattus norvegicus	76-81
24641259-9	2014	Furthermore, amitriptyline-induced Cx43 expression and GJIC were markedly reduced by transcription factor AP-1 inhibitors (curcumin and tanshinone IIA).	Curcumin	123-131	gap junction protein, alpha 1	Rattus norvegicus	35-39
24139527-10	2014	There was a significant heterogeneity for the impact of curcumin on total cholesterol, LDL-C and triglycerides but not HDL-C.	Curcumin	56-64	component of oligomeric golgi complex 2	Homo sapiens	87-92
24926361-1	2014	The aim of the present study was to investigate the inhibitory effect of curcumin on tumor necrosis factor (TNF)-alpha-induced cell migration and matrix metalloproteinase (MMP)-2 expression and activity in rat vascular smooth muscle cells (VSMCs), in order to identify whether the effects are mediated by the nuclear factor (NF)-kappaB signaling pathway.	Curcumin	73-81	tumor necrosis factor	Rattus norvegicus	85-118
24926361-2	2014	The VSMCs cells were pretreated with curcumin prior to stimulation with TNF-alpha.	Curcumin	37-45	tumor necrosis factor	Rattus norvegicus	72-81
24926361-6	2014	Curcumin was found to suppress the TNF-alpha-stimulated migration of VSMCs.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	35-44
24926361-7	2014	In addition, curcumin inhibited the TNF-alpha-induced induction of MMP-2 activity and expression.	Curcumin	13-21	tumor necrosis factor	Rattus norvegicus	36-45
24926361-10	2014	In addition, western blot analysis revealed that curcumin reduced NF-kappaB p65 protein expression in TNF-alpha-stimulated VSMCs at the concentration of 20 and 40 muM.	Curcumin	49-57	synaptotagmin 1	Rattus norvegicus	76-79
24926361-10	2014	In addition, western blot analysis revealed that curcumin reduced NF-kappaB p65 protein expression in TNF-alpha-stimulated VSMCs at the concentration of 20 and 40 muM.	Curcumin	49-57	tumor necrosis factor	Rattus norvegicus	102-111
24926361-11	2014	Therefore, these observations indicated that curcumin suppressed TNF-alpha-stimulated VSMC migration and partially prevented TNF-alpha-induced MMP-2 expression and activity in VSMCs via the NF-kappaB pathway.	Curcumin	45-53	tumor necrosis factor	Rattus norvegicus	65-74
24926361-11	2014	Therefore, these observations indicated that curcumin suppressed TNF-alpha-stimulated VSMC migration and partially prevented TNF-alpha-induced MMP-2 expression and activity in VSMCs via the NF-kappaB pathway.	Curcumin	45-53	tumor necrosis factor	Rattus norvegicus	125-134
24165958-9	2014	CARR) curcumin supplementation trials.	Curcumin	6-14	arrestin 3	Homo sapiens	0-4
24675438-5	2014	Curcumin application increased the wound contraction and decreased the expressions of inflammatory cytokines/enzymes i.e. tumor necrosis factor-alpha, interleukin (IL)-1beta and matrix metalloproteinase-9.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	122-149
24675438-5	2014	Curcumin application increased the wound contraction and decreased the expressions of inflammatory cytokines/enzymes i.e. tumor necrosis factor-alpha, interleukin (IL)-1beta and matrix metalloproteinase-9.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	151-173
24675438-6	2014	Curcumin also increased the levels of anti-inflammatory cytokine i.e. IL-10 and antioxidant enzymes i.e. superoxide dismutase, catalase and glutathione peroxidase.	Curcumin	0-8	catalase	Rattus norvegicus	127-135
24712702-0	2014	Effects of curcumin (Curcuma longa) on learning and spatial memory as well as cell proliferation and neuroblast differentiation in adult and aged mice by upregulating brain-derived neurotrophic factor and CREB signaling.	Curcumin	11-19	cAMP responsive element binding protein 1	Mus musculus	205-209
24642369-7	2014	Furthermore, curcumin obviously up-regulated hippocampal brain derived neurotrophic factor (BDNF), TrkB, phosphatidylinositide 3-kinases (PI3K) protein expressions, respectively as shown in Western blot analysis.	Curcumin	13-21	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	99-103
24482305-5	2014	In EAN sciatic nerves, curcumin treatment suppressed the inflammatory cell accumulation and the expression of interferon (IFN)-gamma, tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-17.	Curcumin	23-31	interleukin 1 beta	Rattus norvegicus	163-185
25011972-0	2014	[Effect of curcumin on the expression of p-STAT3 and IkappaB in db/db mice].	Curcumin	11-19	signal transducer and activator of transcription 3	Mus musculus	43-48
25011972-10	2014	Compared with the db/db mice, curcumin significantly decreased the urinary albumin, inhibited the phosphorylation of STAT3 and the degradation of IkappaB, and reduced the expression of collagen IV and FN in the kidney.	Curcumin	30-38	signal transducer and activator of transcription 3	Mus musculus	117-122
25011972-11	2014	CONCLUSION: Curcumin can obviously decrease albuminuria and attenuate glomerular sclerosis in diabetic db/db mice by inhibiting phosphorylation of STAT3 and degradation of IkappaB.	Curcumin	12-20	signal transducer and activator of transcription 3	Mus musculus	147-152
25135388-4	2014	The aim of the present study was to explore the antinociceptive effect of curcumin and its effect on expression of 11beta-hydroxysteroid dehydrogenase type I enzyme (11betaHSD1) in spinal dorsal horn and DRG in chronic constriction injury (CCI) mode of neuropathic pain of rats.	Curcumin	74-82	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	115-176
25135388-13	2014	Curcumin could alleviate thermal and mechanical hyperalgesia induced by CCI and inhibit the serum cortisol concentration and expression of 11betaHSD1 in the spinal cord and DRG.	Curcumin	0-8	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	139-149
25200041-12	2014	Low concentration of curcumin may play a protective effect against P19-induced immune responses by inhibiting the p38 MAPK pathway in macrophages.	Curcumin	21-29	mitogen-activated protein kinase 14	Homo sapiens	114-117
24642369-8	2014	These findings demonstrated that curcumin mediated the neuroprotection against 6-OHDA-induced hippocampus neurons in rats, which the underlying mechanism is involved in activating BDNF/TrkB-dependent pathway for promoting neural regeneration of hippocampal tissue.	Curcumin	33-41	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	185-189
24735534-2	2014	In cultured WM-115 melanoma cells, curcumin induced mitochondrial membrane potential (MPP) decrease, cyclophilin-D (CyPD)-adenine nucleotide translocator 1 (ANT-1) (two mPTP components) mitochondrial association and cytochrome C release, indicating mPTP opening.	Curcumin	35-43	peptidylprolyl isomerase F	Homo sapiens	101-114
24755072-0	2014	Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-beta25-35 in rat cortical neurons.	Curcumin	23-31	sirtuin 1	Rattus norvegicus	14-19
24755072-6	2014	Furthermore, we found that application of curcumin activated the expression of SIRT1 and subsequently decreased the expression of Bax in the presence of Abeta25-35.	Curcumin	42-50	sirtuin 1	Rattus norvegicus	79-84
24755072-7	2014	The protective effect of curcumin was blocked by SIRT1 siRNA.	Curcumin	25-33	sirtuin 1	Rattus norvegicus	49-54
24735534-4	2014	CyPD is required for curcumin-induced melanoma cell death.	Curcumin	21-29	peptidylprolyl isomerase F	Homo sapiens	0-4
24735534-2	2014	In cultured WM-115 melanoma cells, curcumin induced mitochondrial membrane potential (MPP) decrease, cyclophilin-D (CyPD)-adenine nucleotide translocator 1 (ANT-1) (two mPTP components) mitochondrial association and cytochrome C release, indicating mPTP opening.	Curcumin	35-43	peptidylprolyl isomerase F	Homo sapiens	116-120
24735534-5	2014	The CyPD inhibitor cyclosporin A (CsA) or CyPD siRNA-depletion inhibited curcumin-induced WM-115 cell death and apoptosis, while WM-115 cells with CyPD over-expression were hyper-sensitive to curcumin.	Curcumin	73-81	peptidylprolyl isomerase F	Homo sapiens	4-8
24735534-5	2014	The CyPD inhibitor cyclosporin A (CsA) or CyPD siRNA-depletion inhibited curcumin-induced WM-115 cell death and apoptosis, while WM-115 cells with CyPD over-expression were hyper-sensitive to curcumin.	Curcumin	73-81	peptidylprolyl isomerase F	Homo sapiens	42-46
24755072-8	2014	Taken together, our results suggest that activation of SIRT1 is involved in the neuroprotective action of curcumin.	Curcumin	106-114	sirtuin 1	Rattus norvegicus	55-60
24735534-2	2014	In cultured WM-115 melanoma cells, curcumin induced mitochondrial membrane potential (MPP) decrease, cyclophilin-D (CyPD)-adenine nucleotide translocator 1 (ANT-1) (two mPTP components) mitochondrial association and cytochrome C release, indicating mPTP opening.	Curcumin	35-43	cytochrome c, somatic	Homo sapiens	216-228
24735534-5	2014	The CyPD inhibitor cyclosporin A (CsA) or CyPD siRNA-depletion inhibited curcumin-induced WM-115 cell death and apoptosis, while WM-115 cells with CyPD over-expression were hyper-sensitive to curcumin.	Curcumin	73-81	peptidylprolyl isomerase F	Homo sapiens	42-46
24735534-5	2014	The CyPD inhibitor cyclosporin A (CsA) or CyPD siRNA-depletion inhibited curcumin-induced WM-115 cell death and apoptosis, while WM-115 cells with CyPD over-expression were hyper-sensitive to curcumin.	Curcumin	192-200	peptidylprolyl isomerase F	Homo sapiens	4-8
24735534-3	2014	The mPTP blocker sanglifehrin A (SfA) and ANT-1 siRNA-depletion dramatically inhibited curcumin-induced cytochrome C release and WM-115 cell death.	Curcumin	87-95	cytochrome c, somatic	Homo sapiens	104-116
24735534-5	2014	The CyPD inhibitor cyclosporin A (CsA) or CyPD siRNA-depletion inhibited curcumin-induced WM-115 cell death and apoptosis, while WM-115 cells with CyPD over-expression were hyper-sensitive to curcumin.	Curcumin	192-200	peptidylprolyl isomerase F	Homo sapiens	42-46
24735534-5	2014	The CyPD inhibitor cyclosporin A (CsA) or CyPD siRNA-depletion inhibited curcumin-induced WM-115 cell death and apoptosis, while WM-115 cells with CyPD over-expression were hyper-sensitive to curcumin.	Curcumin	192-200	peptidylprolyl isomerase F	Homo sapiens	42-46
24735534-6	2014	Finally, we found that C6 ceramide enhanced curcumin-induced cytotoxicity probably through facilitating mPTP opening, while CsA and SfA as well as CyPD and ANT-1 siRNAs alleviated C6 ceramide"s effect on curcumin in WM-115 cells.	Curcumin	204-212	peptidylprolyl isomerase F	Homo sapiens	147-151
24886336-9	2014	p300 inhibition, using either siRNA or curcumin reduced p300 activity, Smad acetylation and TGF-beta activity (all p &lt; 0.05 c/w vehicle or scrambled siRNA).	Curcumin	39-47	SMAD family member 7	Rattus norvegicus	71-75
24665465-5	2014	The changes in the expression level of cyt c and caspase-9 in the cytosol upon curcumin-induced apoptosis were detected by using the proposed method, and also the influence of different concentrations and incubation times of curcumin-induced Hela cells was investigated.	Curcumin	79-87	cytochrome c, somatic	Homo sapiens	39-44
24665465-5	2014	The changes in the expression level of cyt c and caspase-9 in the cytosol upon curcumin-induced apoptosis were detected by using the proposed method, and also the influence of different concentrations and incubation times of curcumin-induced Hela cells was investigated.	Curcumin	225-233	cytochrome c, somatic	Homo sapiens	39-44
24468890-2	2014	The objective of this study was to test whether curcumin, a novel Nrf2 activator, can protect the spinal cord against SCI-induced inflammatory damage.	Curcumin	48-56	NFE2 like bZIP transcription factor 2	Rattus norvegicus	66-70
24468890-7	2014	RESULTS: Induction of the Nrf2 activity by curcumin markedly decreased NF-kappaB activation and inflammatory cytokines production in the injured spinal cord.	Curcumin	43-51	NFE2 like bZIP transcription factor 2	Rattus norvegicus	26-30
23879635-0	2014	ApoE enhances nanodisk-mediated curcumin delivery to glioblastoma multiforme cells.	Curcumin	32-40	apolipoprotein E	Homo sapiens	0-4
24508537-0	2014	Curcumin attenuates inflammatory responses by suppressing TLR4-mediated NF-kappaB signaling pathway in lipopolysaccharide-induced mastitis in mice.	Curcumin	0-8	toll-like receptor 4	Mus musculus	58-62
24508537-6	2014	The results showed that curcumin attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in a dose-dependent manner.	Curcumin	24-32	tumor necrosis factor	Mus musculus	145-172
24508537-6	2014	The results showed that curcumin attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in a dose-dependent manner.	Curcumin	24-32	tumor necrosis factor	Mus musculus	174-183
24508537-6	2014	The results showed that curcumin attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in a dose-dependent manner.	Curcumin	24-32	interleukin 6	Mus musculus	186-199
24508537-6	2014	The results showed that curcumin attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in a dose-dependent manner.	Curcumin	24-32	interleukin 6	Mus musculus	201-205
24508537-6	2014	The results showed that curcumin attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in a dose-dependent manner.	Curcumin	24-32	interleukin 1 beta	Mus musculus	211-228
24508537-6	2014	The results showed that curcumin attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in a dose-dependent manner.	Curcumin	24-32	interleukin 1 beta	Mus musculus	230-238
24508537-7	2014	Additionally, Western blotting results showed that curcumin inhibited the phosphorylation of IkappaB-alpha and NF-kappaB p65 and the expression of TLR4.	Curcumin	51-59	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	93-106
24508537-7	2014	Additionally, Western blotting results showed that curcumin inhibited the phosphorylation of IkappaB-alpha and NF-kappaB p65 and the expression of TLR4.	Curcumin	51-59	toll-like receptor 4	Mus musculus	147-151
24508537-8	2014	These results indicated that curcumin has protective effect on mice mastitis and the anti-inflammatory mechanism of curcumin on LPS-induced mastitis in mice may be due to its ability to inhibit TLR4-mediated NF-kappaB signaling pathways.	Curcumin	29-37	toll-like receptor 4	Mus musculus	194-198
24508537-8	2014	These results indicated that curcumin has protective effect on mice mastitis and the anti-inflammatory mechanism of curcumin on LPS-induced mastitis in mice may be due to its ability to inhibit TLR4-mediated NF-kappaB signaling pathways.	Curcumin	116-124	toll-like receptor 4	Mus musculus	194-198
24496855-3	2014	Curcumin also dose-dependently reduced the phosphorylation of proteins Akt and increased expression levels of the genes caspase-3, cytochrome-c, Bax mRNA in LoVo cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	71-74
24496855-3	2014	Curcumin also dose-dependently reduced the phosphorylation of proteins Akt and increased expression levels of the genes caspase-3, cytochrome-c, Bax mRNA in LoVo cells.	Curcumin	0-8	caspase 3	Homo sapiens	120-129
24496855-3	2014	Curcumin also dose-dependently reduced the phosphorylation of proteins Akt and increased expression levels of the genes caspase-3, cytochrome-c, Bax mRNA in LoVo cells.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	131-143
24496855-3	2014	Curcumin also dose-dependently reduced the phosphorylation of proteins Akt and increased expression levels of the genes caspase-3, cytochrome-c, Bax mRNA in LoVo cells.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	145-148
24496855-4	2014	In addition, Curcumin dose-dependently decreased gene Bcl-2 mRNA expression.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	54-59
24496855-6	2014	These in vitro studies suggest that Curcumin may play its anti-cancer actions partly via suppressing PI3K/Akt signal pathway in LoVo cells.	Curcumin	36-44	AKT serine/threonine kinase 1	Homo sapiens	106-109
24438326-0	2014	Curcumin-enhanced chemosensitivity of FDA-approved platinum (II)-based anti-cancer drugs involves downregulation of nuclear endonuclease G and NF-kappaB as well as induction of apoptosis and G2/M arrest.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	143-152
24438326-7	2014	The addition of curcumin suppressed nuclear AIF and EndoG and reversed anti-cancer drugs-induced NF-kappaB expression, suggesting the association of EndoG and NF-kappaB in curcumin-enhanced chemosensitivity.	Curcumin	16-24	nuclear factor kappa B subunit 1	Homo sapiens	97-106
24438326-7	2014	The addition of curcumin suppressed nuclear AIF and EndoG and reversed anti-cancer drugs-induced NF-kappaB expression, suggesting the association of EndoG and NF-kappaB in curcumin-enhanced chemosensitivity.	Curcumin	16-24	nuclear factor kappa B subunit 1	Homo sapiens	159-168
24438326-7	2014	The addition of curcumin suppressed nuclear AIF and EndoG and reversed anti-cancer drugs-induced NF-kappaB expression, suggesting the association of EndoG and NF-kappaB in curcumin-enhanced chemosensitivity.	Curcumin	172-180	nuclear factor kappa B subunit 1	Homo sapiens	159-168
24614199-7	2014	We recently reported that AGEs stimulated HSC activation likely by inhibiting gene expression of AGE-R1 and inducing gene expression of RAGE in HSC, which were eliminated by the antioxidant curcumin.	Curcumin	190-198	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	97-103
24614199-11	2014	Curcumin eliminated the effects of AGEs in HSC by interrupting leptin signaling and activating transcription factor NF-E2 p45-related factor 2 (Nrf2), leading to the elevation of cellular glutathione and the attenuation of oxidative stress.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	116-142
24614199-11	2014	Curcumin eliminated the effects of AGEs in HSC by interrupting leptin signaling and activating transcription factor NF-E2 p45-related factor 2 (Nrf2), leading to the elevation of cellular glutathione and the attenuation of oxidative stress.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	144-148
24614199-12	2014	In conclusions, curcumin eliminated the effects of AGEs on the divergent regulation of gene expression of RAGE and AGE-R1 in HSC by interrupting the AGE-caused activation of leptin signaling, leading to the inhibition of HSC activation.	Curcumin	16-24	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	115-121
23879635-3	2014	RESULTS: When ApoE was employed as the ND scaffold protein, enhanced curcumin uptake was observed.	Curcumin	69-77	apolipoprotein E	Homo sapiens	14-18
23879635-4	2014	Furthermore, ApoE curcumin-NDs induced greater cell death than either free curcumin or ApoAI curcumin-NDs.	Curcumin	18-26	apolipoprotein E	Homo sapiens	13-17
23879635-5	2014	A total of 1 h after exposure of glioblastoma multiforme cells to ApoE curcumin-NDs, significant curcumin uptake was detected while ApoE was localized at the cell surface.	Curcumin	71-79	apolipoprotein E	Homo sapiens	66-70
23879635-5	2014	A total of 1 h after exposure of glioblastoma multiforme cells to ApoE curcumin-NDs, significant curcumin uptake was detected while ApoE was localized at the cell surface.	Curcumin	71-79	apolipoprotein E	Homo sapiens	132-136
23879635-5	2014	A total of 1 h after exposure of glioblastoma multiforme cells to ApoE curcumin-NDs, significant curcumin uptake was detected while ApoE was localized at the cell surface.	Curcumin	97-105	apolipoprotein E	Homo sapiens	66-70
23879635-7	2014	CONCLUSION: ApoE-mediated interaction of curcumin-NDs with glioblastoma multiforme cells leads to enhanced curcumin uptake and increased biological activity.	Curcumin	41-49	apolipoprotein E	Homo sapiens	12-16
23879635-7	2014	CONCLUSION: ApoE-mediated interaction of curcumin-NDs with glioblastoma multiforme cells leads to enhanced curcumin uptake and increased biological activity.	Curcumin	107-115	apolipoprotein E	Homo sapiens	12-16
24604218-8	2014	Curcumin and EF-24 promoted the proteolytic cleavages of procaspase-3/-7/-8/-9 with increases in the amount of cleaved caspase-3/-7/-8/-9.	Curcumin	0-8	caspase 3	Homo sapiens	57-69
24604218-6	2014	The caspase-3/-7 activities were detected in living cells treated with curcumin or EF-24.	Curcumin	71-79	caspase 3	Homo sapiens	4-13
24604218-8	2014	Curcumin and EF-24 promoted the proteolytic cleavages of procaspase-3/-7/-8/-9 with increases in the amount of cleaved caspase-3/-7/-8/-9.	Curcumin	0-8	caspase 3	Homo sapiens	60-69
24604218-9	2014	The curcumin- or EF-24-induced apoptosis in the Saos2 cells was mediated by the expression of Fas and activation of caspase-8, caspase-3 and poly(ADP-ribose) polymerase.	Curcumin	4-12	caspase 3	Homo sapiens	127-136
24604218-9	2014	The curcumin- or EF-24-induced apoptosis in the Saos2 cells was mediated by the expression of Fas and activation of caspase-8, caspase-3 and poly(ADP-ribose) polymerase.	Curcumin	4-12	poly(ADP-ribose) polymerase 1	Homo sapiens	141-168
24604218-10	2014	Immunoblotting revealed the Bid and Bcl-2 proteins to be downregulated, and truncated-Bid, Bax and p53 proteins to be upregulated by curcumin and EF-24.	Curcumin	133-141	BH3 interacting domain death agonist	Homo sapiens	86-89
24604218-10	2014	Immunoblotting revealed the Bid and Bcl-2 proteins to be downregulated, and truncated-Bid, Bax and p53 proteins to be upregulated by curcumin and EF-24.	Curcumin	133-141	BCL2 associated X, apoptosis regulator	Homo sapiens	91-94
24604218-10	2014	Immunoblotting revealed the Bid and Bcl-2 proteins to be downregulated, and truncated-Bid, Bax and p53 proteins to be upregulated by curcumin and EF-24.	Curcumin	133-141	tumor protein p53	Homo sapiens	99-102
24604218-11	2014	Curcumin and EF-24 increased the Bax/Bcl-2 ratio significantly.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	33-36
24604218-11	2014	Curcumin and EF-24 increased the Bax/Bcl-2 ratio significantly.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	37-42
23943298-3	2014	It is known that curcumin inhibits the inducible activation of NFkappaB at least in part by sustaining ikappaB expression level.	Curcumin	17-25	nuclear factor kappa B subunit 1	Homo sapiens	63-71
24815146-11	2014	In addition, curcumin treatment reduced serum ALT level and degrees of TNF-alpha level and MMP-9 activity in the lungs.	Curcumin	13-21	tumor necrosis factor	Rattus norvegicus	71-80
23192861-0	2014	Suppressing the formation of lipid raft-associated Rac1/PI3K/Akt signaling complexes by curcumin inhibits SDF-1alpha-induced invasion of human esophageal carcinoma cells.	Curcumin	88-96	AKT serine/threonine kinase 1	Homo sapiens	61-64
23192861-4	2014	Curcumin suppressed SDF-1alpha-induced cell invasion and matrix metalloproteinase-2 (MMP-2) promoter activity, cell surface localization of CXCR4 at lipid rafts, and lipid raft-associated ras-related C3 botulinum toxin substrate 1 (Rac1)/phosphatidylinositol 3-kinase (PI3K) p85alpha/Akt signaling.	Curcumin	0-8	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	275-283
23192861-4	2014	Curcumin suppressed SDF-1alpha-induced cell invasion and matrix metalloproteinase-2 (MMP-2) promoter activity, cell surface localization of CXCR4 at lipid rafts, and lipid raft-associated ras-related C3 botulinum toxin substrate 1 (Rac1)/phosphatidylinositol 3-kinase (PI3K) p85alpha/Akt signaling.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	284-287
23192861-6	2014	We further demonstrate that the attenuation of lipid raft-associated Rac1 activity by curcumin was critical for the inhibition of SDF-1alpha-induced PI3K/Akt/NF-kappaB activation, cell surface localization of CXCR4 at lipid rafts, MMP-2 promoter activity, and cell invasion.	Curcumin	86-94	AKT serine/threonine kinase 1	Homo sapiens	154-157
23192861-6	2014	We further demonstrate that the attenuation of lipid raft-associated Rac1 activity by curcumin was critical for the inhibition of SDF-1alpha-induced PI3K/Akt/NF-kappaB activation, cell surface localization of CXCR4 at lipid rafts, MMP-2 promoter activity, and cell invasion.	Curcumin	86-94	nuclear factor kappa B subunit 1	Homo sapiens	158-167
23192861-7	2014	Collectively, our results indicate that curcumin inhibits SDF-1alpha-induced EC cell invasion by suppressing the formation of the lipid raft-associated Rac1-PI3K-Akt signaling complex, the localization of CXCR4 with lipid rafts at the cell surface, and MMP-2 promoter activity, likely through the inhibition of Rac1 activity.	Curcumin	40-48	AKT serine/threonine kinase 1	Homo sapiens	162-165
25169090-9	2014	Both paraquat group and curcumin intervention group showed increase in MDA content, decreases in SOD and CAT activities, increases in HO-1 and NQO-1 activities, and increases in the protein and mRNA levels of Nrf2, in comparison with the control group (P &lt; 0.05 for all except HO-1 activity in paraquat group on day 7).	Curcumin	24-32	catalase	Rattus norvegicus	105-108
25169090-9	2014	Both paraquat group and curcumin intervention group showed increase in MDA content, decreases in SOD and CAT activities, increases in HO-1 and NQO-1 activities, and increases in the protein and mRNA levels of Nrf2, in comparison with the control group (P &lt; 0.05 for all except HO-1 activity in paraquat group on day 7).	Curcumin	24-32	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	143-148
25169090-12	2014	CONCLUSION: Oxidative stress plays an important role in paraquat-induced acute liver damage in rats, and curcumin can exert a hepatoprotective effect against oxidative stress by increasing the expression of Nrf2 and the activities of HO-1, NQO-1, SOD, and CAT and reducing the content of MDA.	Curcumin	105-113	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	240-245
25169090-9	2014	Both paraquat group and curcumin intervention group showed increase in MDA content, decreases in SOD and CAT activities, increases in HO-1 and NQO-1 activities, and increases in the protein and mRNA levels of Nrf2, in comparison with the control group (P &lt; 0.05 for all except HO-1 activity in paraquat group on day 7).	Curcumin	24-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	209-213
25169090-12	2014	CONCLUSION: Oxidative stress plays an important role in paraquat-induced acute liver damage in rats, and curcumin can exert a hepatoprotective effect against oxidative stress by increasing the expression of Nrf2 and the activities of HO-1, NQO-1, SOD, and CAT and reducing the content of MDA.	Curcumin	105-113	catalase	Rattus norvegicus	256-259
25169090-10	2014	In comparison with the parquet group on the same day, the curcumin intervention group showed decrease in MDA content, increases in the activities of SOD, CAT, HO-1, and NQO-1, and increases in the mRNA and protein levels of Nrf2 on days 1, 3, and 7 (P &lt; 0.05).	Curcumin	58-66	catalase	Rattus norvegicus	154-157
25169090-10	2014	In comparison with the parquet group on the same day, the curcumin intervention group showed decrease in MDA content, increases in the activities of SOD, CAT, HO-1, and NQO-1, and increases in the mRNA and protein levels of Nrf2 on days 1, 3, and 7 (P &lt; 0.05).	Curcumin	58-66	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	169-174
25169090-10	2014	In comparison with the parquet group on the same day, the curcumin intervention group showed decrease in MDA content, increases in the activities of SOD, CAT, HO-1, and NQO-1, and increases in the mRNA and protein levels of Nrf2 on days 1, 3, and 7 (P &lt; 0.05).	Curcumin	58-66	NFE2 like bZIP transcription factor 2	Rattus norvegicus	224-228
25169090-12	2014	CONCLUSION: Oxidative stress plays an important role in paraquat-induced acute liver damage in rats, and curcumin can exert a hepatoprotective effect against oxidative stress by increasing the expression of Nrf2 and the activities of HO-1, NQO-1, SOD, and CAT and reducing the content of MDA.	Curcumin	105-113	NFE2 like bZIP transcription factor 2	Rattus norvegicus	207-211
24491667-0	2014	Multi-spectroscopic analysis and molecular modeling on the interaction of curcumin and its derivatives with human serum albumin: a comparative study.	Curcumin	74-82	albumin	Homo sapiens	114-127
24689857-6	2014	In addition, mixture 1 and curcumin (2) showed activity on cell cycle arrest at the G0/G1 phase and decreased the FLT3 and STAT5A protein levels in a dose-dependent manner.	Curcumin	27-35	fms related receptor tyrosine kinase 3	Homo sapiens	114-118
24491667-1	2014	The comparative study about the interaction between curcumin and its derivatives (demothxycurcumin and bisdeoxycurcumin) with human serum albumin (HSA) has been carried out using multi-spectroscopic analysis and molecular modeling method.	Curcumin	52-60	albumin	Homo sapiens	132-145
24743574-0	2014	Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	42-45
24642565-2	2014	We demonstrated that 4 of 9 curcumin analogues were selective inhibitors of human and rodent 11beta-HSD1.	Curcumin	28-36	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	93-104
24642565-4	2014	Curcumin analogues weakly inhibited 11beta-HSD2, and further analyses revealed that these compounds were highly selective, favoring 11beta-HSD1.	Curcumin	0-8	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	132-143
24642565-5	2014	These 4 curcumin analogues are potential therapeutic agents for type-2 diabetes by targeting 11beta-HSD1.	Curcumin	8-16	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	93-104
24743574-0	2014	Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	50-54
24743574-13	2014	Ectopic expression of Bcl-2 also inhibited apoptosis in NVP-BE235 plus curcumin-treated cells.	Curcumin	71-79	BCL2 apoptosis regulator	Homo sapiens	22-27
24743574-0	2014	Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability.	Curcumin	0-8	tumor protein p53	Homo sapiens	157-160
24743574-15	2014	Taken together, combined treatment with NVP-BEZ235 and curcumin induces apoptosis through p53-dependent Bcl-2 mRNA down-regulation at the transcriptional level and Mcl-1 protein down-regulation at the post-transcriptional level.	Curcumin	55-63	tumor protein p53	Homo sapiens	90-93
24743574-0	2014	Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	171-176
24743574-15	2014	Taken together, combined treatment with NVP-BEZ235 and curcumin induces apoptosis through p53-dependent Bcl-2 mRNA down-regulation at the transcriptional level and Mcl-1 protein down-regulation at the post-transcriptional level.	Curcumin	55-63	BCL2 apoptosis regulator	Homo sapiens	104-109
24743574-9	2014	Furthermore, the down-regulation of Bcl-2 was involved in curcumin plus NVP-BEZ235-induced apoptosis.	Curcumin	58-66	BCL2 apoptosis regulator	Homo sapiens	36-41
24743574-11	2014	Combined treatment with NVP-BEZ235 and curcumin reduced Bcl-2 expression in wild-type p53 HCT116 human colon carcinoma cells but not p53-null HCT116 cells.	Curcumin	39-47	BCL2 apoptosis regulator	Homo sapiens	56-61
24743574-11	2014	Combined treatment with NVP-BEZ235 and curcumin reduced Bcl-2 expression in wild-type p53 HCT116 human colon carcinoma cells but not p53-null HCT116 cells.	Curcumin	39-47	tumor protein p53	Homo sapiens	86-89
24491504-0	2014	Ensemble docking and molecular dynamics identify knoevenagel curcumin derivatives with potent anti-EGFR activity.	Curcumin	61-69	epidermal growth factor receptor	Homo sapiens	99-103
24583398-15	2014	NAC and curcumin normalize MMP-3 levels mainly in TNFalpha stimulated cells.	Curcumin	8-16	matrix metallopeptidase 3	Homo sapiens	27-32
24583398-15	2014	NAC and curcumin normalize MMP-3 levels mainly in TNFalpha stimulated cells.	Curcumin	8-16	tumor necrosis factor	Homo sapiens	50-58
24583398-16	2014	A modulation of MMP-3 production by NAC and curcumin due to their direct action on transcriptional factors has been also suggested.	Curcumin	44-52	matrix metallopeptidase 3	Homo sapiens	16-21
24491504-3	2014	In the present study, a molecular docking and molecular dynamics investigation has been carried out with an ensemble of EGFR-TK structures against a synthetically feasible library of curcumin analogs to discover potent EGFR inhibitors.	Curcumin	183-191	epidermal growth factor receptor	Homo sapiens	219-223
24491504-6	2014	Finally, the 5 ns molecular dynamics simulation shows that knoevenagel condensate of curcumin specifically C29 and C30 can be used as starting blocks for developing effective leads capable of inhibiting EGFR.	Curcumin	85-93	epidermal growth factor receptor	Homo sapiens	203-207
24486572-6	2014	Moreover, ET-1-induced CTGF expression was significantly reduced by JNK inhibitor (SP600125), the dominant-negative mutants of JNK1/2 (JNK1/2 DN), and AP-1 inhibitor (curcumin).	Curcumin	167-175	endothelin 1	Homo sapiens	10-14
24741294-2	2014	Here, we synthesized 26 asymmetric monocarbonyl analogs of curcumin and evaluated their anti-inflammatory activity by inhibiting the LPS-induced secretion of tumor necrosis factor-alpha and interleukin-6 in mouse RAW264.7 macrophages.	Curcumin	59-67	tumor necrosis factor	Mus musculus	158-185
24741294-2	2014	Here, we synthesized 26 asymmetric monocarbonyl analogs of curcumin and evaluated their anti-inflammatory activity by inhibiting the LPS-induced secretion of tumor necrosis factor-alpha and interleukin-6 in mouse RAW264.7 macrophages.	Curcumin	59-67	interleukin 6	Mus musculus	190-203
24692720-0	2014	Curcumin suppresses vasculogenic mimicry capacity of hepatocellular carcinoma cells through STAT3 and PI3K/AKT inhibition.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	92-97
24692720-0	2014	Curcumin suppresses vasculogenic mimicry capacity of hepatocellular carcinoma cells through STAT3 and PI3K/AKT inhibition.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	107-110
24692720-6	2014	Further study revealed that the anti-VM effect of curcumin was due to inhibition of AKT and STAT3 phosphorylation, as confirmed by specific inhibitors.	Curcumin	50-58	AKT serine/threonine kinase 1	Homo sapiens	84-87
24692720-6	2014	Further study revealed that the anti-VM effect of curcumin was due to inhibition of AKT and STAT3 phosphorylation, as confirmed by specific inhibitors.	Curcumin	50-58	signal transducer and activator of transcription 3	Homo sapiens	92-97
24692720-7	2014	CONCLUSION: Curcumin presents proven potential as an anti-VM agent in HCC cells, through down-regulation of STAT3 and AKT signaling pathways.	Curcumin	12-20	signal transducer and activator of transcription 3	Homo sapiens	108-113
24692720-7	2014	CONCLUSION: Curcumin presents proven potential as an anti-VM agent in HCC cells, through down-regulation of STAT3 and AKT signaling pathways.	Curcumin	12-20	AKT serine/threonine kinase 1	Homo sapiens	118-121
24486572-12	2014	Moreover, we found that ET-1 induced alpha-smooth muscle actin (alpha-SMA) expression, which was inhibited by BQ123, SP600125, curcumin, and anti-CTGF antibody.	Curcumin	127-135	endothelin 1	Homo sapiens	24-28
23666561-2	2014	We previously demonstrated that curcumin, the active ingredient derived from the herb Curcuma longa, inhibits uterine leiomyosarcoma cells in vitro via the inhibition of the AKT-mammalian target of rapamycin (mTOR) pathway.	Curcumin	32-40	mechanistic target of rapamycin kinase	Homo sapiens	209-213
24508477-9	2014	Both curcumin and EGCG effectively reduced acrylamide-induced proliferation, as well as protein expression of CYP2E1, EGFR, cyclin D1 and NF-kappaB.	Curcumin	5-13	epidermal growth factor receptor	Homo sapiens	118-122
24508477-9	2014	Both curcumin and EGCG effectively reduced acrylamide-induced proliferation, as well as protein expression of CYP2E1, EGFR, cyclin D1 and NF-kappaB.	Curcumin	5-13	nuclear factor kappa B subunit 1	Homo sapiens	138-147
23666561-0	2014	Curcumin targets the AKT-mTOR pathway for uterine leiomyosarcoma tumor growth suppression.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	21-24
23666561-14	2014	CONCLUSION: Curcumin inhibited uterine leiomyosarcoma tumor growth in vivo by targeting the AKT-mTOR pathway for inhibition.	Curcumin	12-20	thymoma viral proto-oncogene 1	Mus musculus	92-95
23666561-2	2014	We previously demonstrated that curcumin, the active ingredient derived from the herb Curcuma longa, inhibits uterine leiomyosarcoma cells in vitro via the inhibition of the AKT-mammalian target of rapamycin (mTOR) pathway.	Curcumin	32-40	thymoma viral proto-oncogene 1	Mus musculus	174-177
24460581-12	2014	In addition, the spinal cord tissue and the plasma SOD, GSH, and CAT levels were found to be preserved in the curcumin group and not statistically different from those of the sham group.	Curcumin	110-118	catalase	Oryctolagus cuniculus	65-68
24503718-0	2014	Curcumin synergistically enhances the radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-kappaB activity.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	130-139
24503718-7	2014	Curcumin enhanced SAS/luc radiosensitivity through the inhibition of radiation-induced NF-kappaB activity and expression of effector proteins both in vitro and in vivo.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	87-96
24737429-0	2014	Effects of curcumin on hippocampal expression of NgR and axonal regeneration in Abeta-induced cognitive disorder rats.	Curcumin	11-19	reticulon 4 receptor	Rattus norvegicus	49-52
24365880-2	2014	This study tested the hypothesis that postconditioning (Postcon) or anti-inflammatory compound, curcumin, ameliorates inflammatory responses and further reduces infarct size by normalizing EGR-1 expression during reperfusion.	Curcumin	96-104	early growth response 1	Rattus norvegicus	189-194
25039189-7	2014	Curcumin could significantly increase the expression levels of GRP78 and CHOP in breast cancer cells.	Curcumin	0-8	heat shock protein family A (Hsp70) member 5	Homo sapiens	63-68
25039189-7	2014	Curcumin could significantly increase the expression levels of GRP78 and CHOP in breast cancer cells.	Curcumin	0-8	DNA damage inducible transcript 3	Homo sapiens	73-77
24664296-7	2014	Moreover, the level of activated p53 and PARP-1 were significantly induced by BaP, whereas this induction was markedly reduced after curcumin and VE co-treatment.	Curcumin	133-141	tumor protein p53	Homo sapiens	33-36
23857913-0	2014	Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells.	Curcumin	0-10	mitogen-activated protein kinase 14	Homo sapiens	92-95
23857913-0	2014	Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells.	Curcumin	0-10	caspase 3	Homo sapiens	117-126
23857913-4	2014	Pretreatment of SH-SY5Y with curcumin I at concentrations of 1, 5, 10, and 20 muM, significantly decreased the formation of quinoprotein and reduced the levels of p-p38 and cleaved caspase-3 in a dose-dependent manner.	Curcumin	29-39	latexin	Homo sapiens	78-81
23857913-4	2014	Pretreatment of SH-SY5Y with curcumin I at concentrations of 1, 5, 10, and 20 muM, significantly decreased the formation of quinoprotein and reduced the levels of p-p38 and cleaved caspase-3 in a dose-dependent manner.	Curcumin	29-39	mitogen-activated protein kinase 14	Homo sapiens	165-168
23857913-4	2014	Pretreatment of SH-SY5Y with curcumin I at concentrations of 1, 5, 10, and 20 muM, significantly decreased the formation of quinoprotein and reduced the levels of p-p38 and cleaved caspase-3 in a dose-dependent manner.	Curcumin	29-39	caspase 3	Homo sapiens	181-190
23857913-6	2014	Our results clearly demonstrated that curcumin I protects neurons against oxidative damage, as shown by attenuation of p-p38 expression, caspase-3-activation, and toxic quinoprotein formation, together with the restoration of p-TH levels.	Curcumin	38-48	mitogen-activated protein kinase 14	Homo sapiens	121-124
23857913-6	2014	Our results clearly demonstrated that curcumin I protects neurons against oxidative damage, as shown by attenuation of p-p38 expression, caspase-3-activation, and toxic quinoprotein formation, together with the restoration of p-TH levels.	Curcumin	38-48	caspase 3	Homo sapiens	137-146
24669820-0	2014	Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-kappaB signaling pathway in experimental traumatic brain injury.	Curcumin	0-8	toll-like receptor 4	Mus musculus	64-68
24669820-0	2014	Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-kappaB signaling pathway in experimental traumatic brain injury.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-84
24669820-10	2014	In addition to improvement in the above aspects, 100 mg/kg curcumin treatment post-TBI significantly reduced the number of TLR4-positive microglia/macrophages as well as inflammatory mediator release and neuronal apoptosis in WT mice.	Curcumin	59-67	toll-like receptor 4	Mus musculus	123-127
24669820-11	2014	Furthermore, Western blot analysis indicated that the levels of TLR4 and its known downstream effectors (MyD88, and NF-kappaB) were also decreased after curcumin treatment.	Curcumin	153-161	toll-like receptor 4	Mus musculus	64-68
24669820-11	2014	Furthermore, Western blot analysis indicated that the levels of TLR4 and its known downstream effectors (MyD88, and NF-kappaB) were also decreased after curcumin treatment.	Curcumin	153-161	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	116-125
24669820-14	2014	The increased protein levels of TLR4, MyD88 and NF-kappaB in microglia were attenuated by curcumin treatment.	Curcumin	90-98	toll-like receptor 4	Mus musculus	32-36
24669820-14	2014	The increased protein levels of TLR4, MyD88 and NF-kappaB in microglia were attenuated by curcumin treatment.	Curcumin	90-98	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	48-57
24669820-15	2014	CONCLUSIONS: Our results suggest that post-injury, curcumin administration may improve patient outcome by reducing acute activation of microglia/macrophages and neuronal apoptosis through a mechanism involving the TLR4/MyD88/NF-kappaB signaling pathway in microglia/macrophages in TBI.	Curcumin	51-59	nuclear factor kappa B subunit 1	Homo sapiens	225-234
24753768-0	2014	Curcumin regulates hepatoma cell proliferation and apoptosis through the Notch signaling pathway.	Curcumin	0-8	notch receptor 1	Homo sapiens	73-78
24645646-11	2014	We also found that EMF exposure significantly increased the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-1beta) and the production of NO; however, these increases were efficiently chilled by the addition of curcumin to the culture medium.	Curcumin	226-234	tumor necrosis factor	Mus musculus	101-110
24645646-11	2014	We also found that EMF exposure significantly increased the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-1beta) and the production of NO; however, these increases were efficiently chilled by the addition of curcumin to the culture medium.	Curcumin	226-234	interleukin 6	Mus musculus	112-116
24645646-11	2014	We also found that EMF exposure significantly increased the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-1beta) and the production of NO; however, these increases were efficiently chilled by the addition of curcumin to the culture medium.	Curcumin	226-234	interleukin 1 beta	Mus musculus	121-129
24645646-14	2014	Moreover, curcumin significantly reduced the expression of NF-kappaB p65 in nuclei and phospho-STAT3 (p-STAT3) in cytosols and nuclei.	Curcumin	10-18	signal transducer and activator of transcription 3	Mus musculus	95-100
24645646-14	2014	Moreover, curcumin significantly reduced the expression of NF-kappaB p65 in nuclei and phospho-STAT3 (p-STAT3) in cytosols and nuclei.	Curcumin	10-18	signal transducer and activator of transcription 3	Mus musculus	104-109
24645646-15	2014	CONCLUSIONS: This study indicates that curcumin ameliorates the depressed MFG-E8 expression and the attenuated phagocytic ability of EMF-exposed N9 cells, which is attributable to the inhibition of the pro-inflammatory response through the NF-kappaB and STAT3 pathways.	Curcumin	39-47	signal transducer and activator of transcription 3	Mus musculus	254-259
24753768-6	2014	To determine whether curcumin exerts these effects by altering the Notch signaling pathway, a phenomenon reported for other cancers, relative expression of Notch1 mRNA and protein were determined in curcumin-treated cells.	Curcumin	199-207	notch receptor 1	Homo sapiens	156-162
24753768-7	2014	Both mRNA and protein expression of Notch1 decreased with increasing curcumin dose (P &lt; 0.05).	Curcumin	69-77	notch receptor 1	Homo sapiens	36-42
24753768-8	2014	Thus, curcumin appears to inhibit proliferation and induce apoptosis in hepatoma cells by altering the Notch signaling pathway.	Curcumin	6-14	notch receptor 1	Homo sapiens	103-108
24469677-0	2014	Syntheses and photophysical properties of BF2 complexes of curcumin analogues.	Curcumin	59-67	forkhead box G1	Homo sapiens	42-45
24597901-3	2014	Here we assessed the anti-BACE-1 and behavioral activities of curcuminoids from rhizomes of Curcuma longa (Zingiberaceae), diarylalkyls curcumin (CCN), demethoxycurcumin (DMCCN), and bisdemethoxycurcumin (BDMCCN) against AD Drosophila melanogaster models.	Curcumin	62-70	beta-secretase 1	Homo sapiens	26-32
24625971-0	2014	Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin.	Curcumin	129-137	DNA damage inducible transcript 3	Homo sapiens	43-47
24597901-6	2014	RESULTS: BDMCCN has the strongest inhibitory activity toward BACE-1 with 17 muM IC50, which was 20 and 13 times lower than those of CCN and DMCCN respectively.	Curcumin	12-15	beta-secretase 1	Homo sapiens	61-67
24603537-0	2014	Antioxidant properties and PC12 cell protective effects of a novel curcumin analogue (2E,6E)-2,6-bis(3,5- dimethoxybenzylidene)cyclohexanone (MCH).	Curcumin	67-75	oleoyl-ACP hydrolase	Rattus norvegicus	142-145
24081825-3	2014	Within a dose range of 10 to 30 muM and a treatment period of 24 hours, the cytotoxicity of curcumin was low, as determined by MTT assays.	Curcumin	92-100	latexin	Homo sapiens	32-35
24603537-1	2014	The antioxidative properties of a novel curcumin analogue (2E,6E)-2,6-bis(3,5-dimethoxybenzylidene)cyclohexanone (MCH) were assessed by several in vitro models, including superoxide anion, hydroxyl radical and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and PC12 cell protection from H2O2 damage.	Curcumin	40-48	oleoyl-ACP hydrolase	Rattus norvegicus	114-117
24081825-6	2014	Treatment with 10, 15, and 20 muM curcumin decreased the number of plaques produced, caused an intracellular accumulation of viral proteins, and increased the level of Lys48 ubiquitin-conjugated proteins.	Curcumin	34-42	latexin	Homo sapiens	30-33
24431405-9	2014	PCR array analysis using the human inflammasome template revealed that curcumin significantly downregulated levels of inflammasome-related gene expression involved in inflammation, e.g., NF-kappaB, toll-like receptors (TLR), and IL-1beta.	Curcumin	71-79	interleukin 1 beta	Homo sapiens	229-237
24741455-11	2014	Additionally, curcumin inhibited docetaxel-induced p65 activation and COX-2 expression.	Curcumin	14-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	70-75
24431405-5	2014	Using in vitro models with mouse and human malignant mesothelioma cells, curcumin is shown to induce pyroptosis through activation of caspase-1 and increased release of high-mobility group box 1 (HMGB1) without processing of IL-1beta and IL-18.	Curcumin	73-81	caspase 1	Homo sapiens	134-143
24431405-5	2014	Using in vitro models with mouse and human malignant mesothelioma cells, curcumin is shown to induce pyroptosis through activation of caspase-1 and increased release of high-mobility group box 1 (HMGB1) without processing of IL-1beta and IL-18.	Curcumin	73-81	interleukin 1 beta	Homo sapiens	225-233
24431405-6	2014	Absence of IL-1beta processing in response to curcumin-mediated caspase-1 activation is attributed to blockade of pro-IL-1beta priming through inhibition of the NF-kappaB pathway.	Curcumin	46-54	interleukin 1 beta	Homo sapiens	11-19
24431405-6	2014	Absence of IL-1beta processing in response to curcumin-mediated caspase-1 activation is attributed to blockade of pro-IL-1beta priming through inhibition of the NF-kappaB pathway.	Curcumin	46-54	caspase 1	Homo sapiens	64-73
24431405-6	2014	Absence of IL-1beta processing in response to curcumin-mediated caspase-1 activation is attributed to blockade of pro-IL-1beta priming through inhibition of the NF-kappaB pathway.	Curcumin	46-54	interleukin 1 beta	Homo sapiens	114-126
24431405-7	2014	Furthermore, curcumin"s cytotoxicity in malignant mesothelioma cells is demonstrated to be dependent on pyroptosis as inhibition of caspase-1 resulted in protection against curcumin-induced cell death.	Curcumin	13-21	caspase 1	Homo sapiens	132-141
24431405-7	2014	Furthermore, curcumin"s cytotoxicity in malignant mesothelioma cells is demonstrated to be dependent on pyroptosis as inhibition of caspase-1 resulted in protection against curcumin-induced cell death.	Curcumin	173-181	caspase 1	Homo sapiens	132-141
24431405-8	2014	We also demonstrate that curcumin-mediated caspase-1 activation is oxidant dependent by using N-acetyl-L-cysteine (NAC) to inhibit pyroptosis.	Curcumin	25-33	caspase 1	Homo sapiens	43-52
24648190-4	2014	Two analogs, CA2 and CA3, had lower potencies as anticancer agents compared with curcumin, while CA6 had a slightly higher IC50 value.	Curcumin	81-89	carbonic anhydrase 3	Homo sapiens	21-24
24648190-7	2014	The cell culture-based reactive oxygen species/reactive nitrogen species assay indicated that CA3 and CA6 were equal to curcumin in their free radical scavenging ability at the same concentration, but when curcumin and its analogs were tested at their respective IC50 values, CA4 and CA5 showed excellent antioxidant capacities.	Curcumin	206-214	carbonic anhydrase 3	Homo sapiens	94-97
24741455-12	2014	CONCLUSION: We conclude that curcumin may enhance docetaxel"s antitumor activity in ATC cells by interfering with NF-kappaB and COX-2.	Curcumin	29-37	nuclear factor kappa B subunit 1	Homo sapiens	114-123
24741455-12	2014	CONCLUSION: We conclude that curcumin may enhance docetaxel"s antitumor activity in ATC cells by interfering with NF-kappaB and COX-2.	Curcumin	29-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	128-133
24716415-0	2014	Curcumin induces apoptosis via simultaneously targeting AKT/mTOR and RAF/MEK/ERK survival signaling pathways in human leukemia THP-1 cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	56-59
24520264-6	2014	Briefly, curcumin and puerarin significantly downregulated the levels of tumor necrosis factor-alpha in the blood serum of mice (P&lt;0.01, versus the MCD group).	Curcumin	9-17	tumor necrosis factor	Mus musculus	73-100
24520264-8	2014	The concentration of interleukin-6 was downregulated by curcumin only (P&lt;0.01, versus the MCD group).	Curcumin	56-64	interleukin 6	Mus musculus	21-34
24039193-1	2014	SCOPE: The cathelicidin antimicrobial peptide (CAMP) gene is induced by 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2 D3), lithocholic acid, curcumin, nicotinamide, and butyrate.	Curcumin	141-149	cathelicidin antimicrobial peptide	Homo sapiens	11-45
24039193-1	2014	SCOPE: The cathelicidin antimicrobial peptide (CAMP) gene is induced by 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2 D3), lithocholic acid, curcumin, nicotinamide, and butyrate.	Curcumin	141-149	cathelicidin antimicrobial peptide	Homo sapiens	47-51
24382451-9	2014	Curcumin, a compound with both anti-oxidant and JNK inhibitory properties, specifically protects axons, but not neuronal cell bodies, from NO-mediated degeneration.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	48-51
24313805-0	2014	Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	0-8	CaMKII_AD domain-containing protein;Calcium/calmodulin-dependent protein kinase;Calcium/calmodulin-dependent protein kinase type II	Caenorhabditis elegans	116-122
24313805-0	2014	Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	0-8	Dual specificity mitogen-activated protein kinase kinase sek-1	Caenorhabditis elegans	124-129
24313805-0	2014	Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	0-8	Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1	Caenorhabditis elegans	138-145
24313805-0	2014	Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	0-8	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	151-156
24313805-5	2014	Moreover, curcumin induced the expression of the gst-4 and hsp-16.2 stress response genes.	Curcumin	10-18	Glutathione S-transferase 4	Caenorhabditis elegans	49-54
24313805-6	2014	Lastly, our findings from the mechanistic study in this investigation suggest that the antioxidative effect of curcumin is mediated via regulation of age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	111-119	CaMKII_AD domain-containing protein;Calcium/calmodulin-dependent protein kinase;Calcium/calmodulin-dependent protein kinase type II	Caenorhabditis elegans	178-184
24313805-6	2014	Lastly, our findings from the mechanistic study in this investigation suggest that the antioxidative effect of curcumin is mediated via regulation of age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	111-119	Dual specificity mitogen-activated protein kinase kinase sek-1	Caenorhabditis elegans	186-191
24313805-6	2014	Lastly, our findings from the mechanistic study in this investigation suggest that the antioxidative effect of curcumin is mediated via regulation of age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	111-119	Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1	Caenorhabditis elegans	200-207
24313805-6	2014	Lastly, our findings from the mechanistic study in this investigation suggest that the antioxidative effect of curcumin is mediated via regulation of age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	111-119	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	Caenorhabditis elegans	213-218
24716415-0	2014	Curcumin induces apoptosis via simultaneously targeting AKT/mTOR and RAF/MEK/ERK survival signaling pathways in human leukemia THP-1 cells.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	60-64
24716415-0	2014	Curcumin induces apoptosis via simultaneously targeting AKT/mTOR and RAF/MEK/ERK survival signaling pathways in human leukemia THP-1 cells.	Curcumin	0-8	mitogen-activated protein kinase kinase 7	Homo sapiens	73-76
24716415-0	2014	Curcumin induces apoptosis via simultaneously targeting AKT/mTOR and RAF/MEK/ERK survival signaling pathways in human leukemia THP-1 cells.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	77-80
24716415-7	2014	Curcumin significantly inhibited the activations of AKT/mTOR and RAF/MEK/ERK signaling pathways simultaneously.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	52-55
24716415-7	2014	Curcumin significantly inhibited the activations of AKT/mTOR and RAF/MEK/ERK signaling pathways simultaneously.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	56-60
24716415-7	2014	Curcumin significantly inhibited the activations of AKT/mTOR and RAF/MEK/ERK signaling pathways simultaneously.	Curcumin	0-8	mitogen-activated protein kinase kinase 7	Homo sapiens	69-72
24716415-7	2014	Curcumin significantly inhibited the activations of AKT/mTOR and RAF/MEK/ERK signaling pathways simultaneously.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	73-76
24716415-8	2014	CONCLUSION: This study demonstrates that curcumin inhibits proliferation and induces apoptosis in THP-1 cells via inhibiting the activations of AKT/mTOR and RAF/MEK/ERK signaling pathways simultaneously.	Curcumin	41-49	AKT serine/threonine kinase 1	Homo sapiens	144-147
24716415-8	2014	CONCLUSION: This study demonstrates that curcumin inhibits proliferation and induces apoptosis in THP-1 cells via inhibiting the activations of AKT/mTOR and RAF/MEK/ERK signaling pathways simultaneously.	Curcumin	41-49	mechanistic target of rapamycin kinase	Homo sapiens	148-152
24716415-8	2014	CONCLUSION: This study demonstrates that curcumin inhibits proliferation and induces apoptosis in THP-1 cells via inhibiting the activations of AKT/mTOR and RAF/MEK/ERK signaling pathways simultaneously.	Curcumin	41-49	mitogen-activated protein kinase kinase 7	Homo sapiens	161-164
24716415-8	2014	CONCLUSION: This study demonstrates that curcumin inhibits proliferation and induces apoptosis in THP-1 cells via inhibiting the activations of AKT/mTOR and RAF/MEK/ERK signaling pathways simultaneously.	Curcumin	41-49	mitogen-activated protein kinase 1	Homo sapiens	165-168
24678280-7	2014	RESULTS: Mean serum IL-1beta (P = 0.042), IL-4 (P = 0.008), and VEGF (P = 0.01) were found to be significantly reduced by curcumin therapy.	Curcumin	122-130	interleukin 1 beta	Homo sapiens	20-28
24591829-0	2014	Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells.	Curcumin	71-79	epithelial cell adhesion molecule	Homo sapiens	0-33
24591829-2	2014	In this work CUR-NPs (curcumin-loaded lipid-polymer-lecithin hybrid nanoparticles) were synthesized and functionalized with ribonucleic acid (RNA) Aptamers (Apts) against epithelial cell adhesion molecule (EpCAM) for targeted delivery to colorectal adenocarcinoma cells.	Curcumin	22-30	epithelial cell adhesion molecule	Homo sapiens	171-204
24749345-9	2014	CONCLUSION: Curcumin may partly prevent the lung injury induced by prolonged hyperoxia exposure in neonatal rats probably via modulating the expressions of IL-6, IL-10 and IGF-I in serum and lung tissue.	Curcumin	12-20	interleukin 6	Rattus norvegicus	156-160
24586752-11	2014	The NF-kappaB inhibitor curcumin significantly inhibited PaCDase-induced expression of IL-8 and endothelin-1.	Curcumin	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
24586752-11	2014	The NF-kappaB inhibitor curcumin significantly inhibited PaCDase-induced expression of IL-8 and endothelin-1.	Curcumin	24-32	endothelin 1	Homo sapiens	96-108
24513290-7	2014	Furthermore, curcumin, a histone acetyltransferase (HAT) inhibitor, significantly reduced the level of H3ac in the IL-6 promoter, as well as IL-6 mRNA expression and IL-6 protein secretion by RASFs.	Curcumin	13-21	interleukin 6	Homo sapiens	115-119
24513290-7	2014	Furthermore, curcumin, a histone acetyltransferase (HAT) inhibitor, significantly reduced the level of H3ac in the IL-6 promoter, as well as IL-6 mRNA expression and IL-6 protein secretion by RASFs.	Curcumin	13-21	interleukin 6	Homo sapiens	141-145
24513290-7	2014	Furthermore, curcumin, a histone acetyltransferase (HAT) inhibitor, significantly reduced the level of H3ac in the IL-6 promoter, as well as IL-6 mRNA expression and IL-6 protein secretion by RASFs.	Curcumin	13-21	interleukin 6	Homo sapiens	141-145
24591829-2	2014	In this work CUR-NPs (curcumin-loaded lipid-polymer-lecithin hybrid nanoparticles) were synthesized and functionalized with ribonucleic acid (RNA) Aptamers (Apts) against epithelial cell adhesion molecule (EpCAM) for targeted delivery to colorectal adenocarcinoma cells.	Curcumin	22-30	epithelial cell adhesion molecule	Homo sapiens	206-211
24570592-0	2014	Synergism from the combination of ulinastatin and curcumin offers greater inhibition against colorectal cancer liver metastases via modulating matrix metalloproteinase-9 and E-cadherin expression.	Curcumin	50-58	cadherin 1	Homo sapiens	174-184
24570592-2	2014	The current study was to investigate the ability of ulinastatin (UTI) and curcumin (CUR) to inhibit CRC liver metastases via modulating matrix metalloproteinase-9 (MMP-9) and E-cadherin expression.	Curcumin	74-82	cadherin 1	Homo sapiens	175-185
24678280-7	2014	RESULTS: Mean serum IL-1beta (P = 0.042), IL-4 (P = 0.008), and VEGF (P = 0.01) were found to be significantly reduced by curcumin therapy.	Curcumin	122-130	interleukin 4	Homo sapiens	42-46
24678280-7	2014	RESULTS: Mean serum IL-1beta (P = 0.042), IL-4 (P = 0.008), and VEGF (P = 0.01) were found to be significantly reduced by curcumin therapy.	Curcumin	122-130	vascular endothelial growth factor A	Homo sapiens	64-68
24678280-9	2014	CONCLUSIONS: The findings of the present trial suggested that curcumin may exert immunomodulatory effects via altering the circulating concentrations of IL-1beta, IL-4, and VEGF.	Curcumin	62-70	interleukin 1 beta	Homo sapiens	153-161
24678280-9	2014	CONCLUSIONS: The findings of the present trial suggested that curcumin may exert immunomodulatory effects via altering the circulating concentrations of IL-1beta, IL-4, and VEGF.	Curcumin	62-70	interleukin 4	Homo sapiens	163-167
24678280-9	2014	CONCLUSIONS: The findings of the present trial suggested that curcumin may exert immunomodulatory effects via altering the circulating concentrations of IL-1beta, IL-4, and VEGF.	Curcumin	62-70	vascular endothelial growth factor A	Homo sapiens	173-177
24445038-9	2014	Our results showed that curcumin intervention significantly reduced pulse wave velocity, increased level of serum adiponectin and decreased level of leptin.	Curcumin	24-32	adiponectin, C1Q and collagen domain containing	Homo sapiens	114-125
24316441-3	2014	In this study, we demonstrated that curcumin, a natural product which functions as an anti-inflammatory agent, inhibited the activation of signal transducer and activator of transcription-3 and NF-kappa B in the injured spinal cord.	Curcumin	36-44	signal transducer and activator of transcription 3	Mus musculus	139-189
24316441-3	2014	In this study, we demonstrated that curcumin, a natural product which functions as an anti-inflammatory agent, inhibited the activation of signal transducer and activator of transcription-3 and NF-kappa B in the injured spinal cord.	Curcumin	36-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	194-204
24316441-4	2014	Curcumin treatment greatly reduced the astrogliosis in SCI mice and significantly decreased the expression of IL-1beta and NO, as well as the number of Iba1(+) inflammatory cells at the lesion site.	Curcumin	0-8	interleukin 1 beta	Mus musculus	110-118
24273069-8	2014	Data showed that, 3 months after administration, curcumin treatment reduced Abeta40 , Abeta42 , and aggregation of Abeta-derived diffusible ligands in the mouse hippocampal CA1 area; reduced the expression of the gamma-secretase component presenilin-2; and increased the expression of beta-amyloid-degrading enzymes, including insulin-degrading enzymes and neprilysin.	Curcumin	49-57	presenilin 2	Mus musculus	239-251
24273069-9	2014	This evidence suggests that curcumin, as a potential AD therapeutic method, can reduce beta-amyloid pathological aggregation, possibly through mechanisms that prevent its production by inhibiting presenilin-2 and/or by accelerating its clearance by increasing degrading enzymes such as insulin-degrading enzyme and neprilysin.	Curcumin	28-36	presenilin 2	Mus musculus	196-208
24273069-9	2014	This evidence suggests that curcumin, as a potential AD therapeutic method, can reduce beta-amyloid pathological aggregation, possibly through mechanisms that prevent its production by inhibiting presenilin-2 and/or by accelerating its clearance by increasing degrading enzymes such as insulin-degrading enzyme and neprilysin.	Curcumin	28-36	insulin degrading enzyme	Mus musculus	286-310
24445050-0	2014	Down-regulation of epidermal growth factor receptor by curcumin-induced UBE1L in human bronchial epithelial cells.	Curcumin	55-63	epidermal growth factor receptor	Homo sapiens	19-51
24445050-3	2014	Curcumin, a well-studied chemopreventive agent, is known to down-regulate EGFR.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	74-78
24445050-4	2014	The present study demonstrated that curcumin decreased EGFR expression in human bronchial epithelial (HBE) Beas-2B cells and lung cancer A549 cells.	Curcumin	36-44	epidermal growth factor receptor	Homo sapiens	55-59
24445050-8	2014	Curcumin decreased EGFR downstream signaling pAKT and nuclear factor kappaB (NF-kappaB).	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	19-23
24498401-4	2014	Spectroscopic analysis using site specific probes on human serum albumin (HSA) clearly indicated that curcumin (Cur), demethylcurcumin (Dmc) and bisdemethoxycurcumin (Bdmc) bind to both Site I (sub-site Ia and Ib) and Site II on HSA.	Curcumin	102-110	albumin	Homo sapiens	59-72
24307199-8	2014	Finally, 3-BrP was seen to cooperate with antitumor agents like arsenic trioxide and curcumin in causing cell death, a response apparently mediated by both the generation of oxidative stress induced by 3-BrP and the attenuation of Akt and ERK activation by curcumin.	Curcumin	85-93	AKT serine/threonine kinase 1	Homo sapiens	231-234
24307199-8	2014	Finally, 3-BrP was seen to cooperate with antitumor agents like arsenic trioxide and curcumin in causing cell death, a response apparently mediated by both the generation of oxidative stress induced by 3-BrP and the attenuation of Akt and ERK activation by curcumin.	Curcumin	85-93	mitogen-activated protein kinase 1	Homo sapiens	239-242
24188406-0	2014	Curcumin attenuates amyloid-beta-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3beta signaling pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	118-121
24188406-5	2014	The results indicated that curcumin inhibits Abeta-induced tau phosphorylation at Thr231 and Ser396, over-expression of HDAC6, and decrease in phosphorylation of glycogen synthase kinase-3beta (GSK-3beta) at Ser9.	Curcumin	27-35	amyloid beta precursor protein	Homo sapiens	45-50
24188406-5	2014	The results indicated that curcumin inhibits Abeta-induced tau phosphorylation at Thr231 and Ser396, over-expression of HDAC6, and decrease in phosphorylation of glycogen synthase kinase-3beta (GSK-3beta) at Ser9.	Curcumin	27-35	histone deacetylase 6	Homo sapiens	120-125
24188406-6	2014	However, the protective effect of curcumin on dephosphorylation of GSK-3beta induced by Abeta is not directly related to cellular oxidative stress.	Curcumin	34-42	amyloid beta precursor protein	Homo sapiens	88-93
24188406-7	2014	Curcumin depresses Abeta-induced down-regulation of phosphorylations of Akt at Thr308 and Ser473 and 3-phosphoinositide-dependent protein kinase 1 at Ser241, implying that second message PIP3 involves curcumin-protective cell signaling.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	19-24
24287376-3	2014	We discovered that curcumin treatment could promote the number of processes, mean process length, and maximum process length of primary neurons, which were inhibited by reggie-1 siRNAs or extracellular signal-regulated kinase (ERK) 1/2 antagonist.	Curcumin	19-27	mitogen-activated protein kinase 3	Homo sapiens	188-235
24188406-7	2014	Curcumin depresses Abeta-induced down-regulation of phosphorylations of Akt at Thr308 and Ser473 and 3-phosphoinositide-dependent protein kinase 1 at Ser241, implying that second message PIP3 involves curcumin-protective cell signaling.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	72-75
24188406-7	2014	Curcumin depresses Abeta-induced down-regulation of phosphorylations of Akt at Thr308 and Ser473 and 3-phosphoinositide-dependent protein kinase 1 at Ser241, implying that second message PIP3 involves curcumin-protective cell signaling.	Curcumin	201-209	amyloid beta precursor protein	Homo sapiens	19-24
24188406-7	2014	Curcumin depresses Abeta-induced down-regulation of phosphorylations of Akt at Thr308 and Ser473 and 3-phosphoinositide-dependent protein kinase 1 at Ser241, implying that second message PIP3 involves curcumin-protective cell signaling.	Curcumin	201-209	AKT serine/threonine kinase 1	Homo sapiens	72-75
24188406-10	2014	Curcumin depresses Abeta-induced up-regulation of PTEN induced by Abeta.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	19-24
24188406-10	2014	Curcumin depresses Abeta-induced up-regulation of PTEN induced by Abeta.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	66-71
24188406-11	2014	These results imply that curcumin inhibits Abeta-induced tau hyperphosphorylation involving PTEN/Akt/GSK-3beta pathway.	Curcumin	25-33	amyloid beta precursor protein	Homo sapiens	43-48
24188406-11	2014	These results imply that curcumin inhibits Abeta-induced tau hyperphosphorylation involving PTEN/Akt/GSK-3beta pathway.	Curcumin	25-33	AKT serine/threonine kinase 1	Homo sapiens	97-100
23934646-2	2014	The neuroprotective functions of curcumin derivatives were assessed in motor neurons transfected with mutant TDP-43.	Curcumin	33-41	TAR DNA binding protein	Homo sapiens	109-115
23934646-3	2014	We found that curcumin derivatives reduced the levels of TDP-43 fragments.	Curcumin	14-22	TAR DNA binding protein	Homo sapiens	57-63
24445050-8	2014	Curcumin decreased EGFR downstream signaling pAKT and nuclear factor kappaB (NF-kappaB).	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	69-75
24445050-8	2014	Curcumin decreased EGFR downstream signaling pAKT and nuclear factor kappaB (NF-kappaB).	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	77-86
24445050-11	2014	These results uncover a novel chemopreventive mechanism of curcumin in inducing UBE1L and down-regulating EGFR signaling in HBE cells.	Curcumin	59-67	epidermal growth factor receptor	Homo sapiens	106-110
24287376-4	2014	Furthermore, curcumin-induced neurite growth was related to the ERK1/2 phosphorylation, which was blocked by reggie-1 knockdown.	Curcumin	13-21	mitogen-activated protein kinase 3	Homo sapiens	64-70
24287376-5	2014	Overall, our results implied that curcumin could mediate neurite outgrowth through reggie-1 and ERK1/2 pathway.	Curcumin	34-42	mitogen-activated protein kinase 3	Homo sapiens	96-102
24461029-7	2014	CONCLUSION: A formulation of curcumin with a combination of hydrophilic carrier, cellulosic derivatives and natural antioxidants significantly increases curcuminoid appearance in the blood in comparison to unformulated standard curcumin CS, CTR and CP.	Curcumin	29-37	calcitonin receptor	Homo sapiens	241-244
24401215-15	2014	Curcumin at medium doses of 500-1000 mg/kg diet was effective at reducing fatty streak formation and suppressing aortic expression of IL-6 in the descending aorta and blood levels of several inflammatory cytokines, but at a higher dose (HF + HC, 1500 mg/kg diet), it had adverse effects on some of these parameters.	Curcumin	0-8	interleukin 6	Mus musculus	134-138
24465597-6	2014	RESULTS: Celastrol, resveratrol, sulphoraphane and curcumin inhibited the NF-kappaB promoter activity significantly and in a dose dependent manner.	Curcumin	51-59	nuclear factor kappa B subunit 1	Homo sapiens	74-83
24482695-6	2014	Additionally, Western blotting revealed that expression of p-ERK-1/2, MMP-9, and TIMP-1 was altered following curcumin treatment, also in a dose-dependent manner.	Curcumin	110-118	mitogen-activated protein kinase 1	Mus musculus	61-68
24482695-6	2014	Additionally, Western blotting revealed that expression of p-ERK-1/2, MMP-9, and TIMP-1 was altered following curcumin treatment, also in a dose-dependent manner.	Curcumin	110-118	tissue inhibitor of metalloproteinase 1	Mus musculus	81-87
25492461-2	2014	The method is based on changes in the absorbance of difluoroboron-curcumin (BF2-curcumin), prepared by the reaction of borontrifluoride diethyletherate ((C2H5)2OBF3) and curcumin.	Curcumin	66-74	forkhead box G1	Homo sapiens	76-79
24935585-0	2014	Curcumin induces apoptosis in SGC-7901 gastric adenocarcinoma cells via regulation of mitochondrial signaling pathways.	Curcumin	0-8	sarcoglycan beta	Homo sapiens	30-33
24935585-3	2014	In this study, the anticancer efficacy of curcumin was investigated in human gastric adenocarcinoma SGC-7901 cells.	Curcumin	42-50	sarcoglycan beta	Homo sapiens	100-103
24935585-6	2014	Curcumin-induced apoptosis of SGC-7901 cells was associated with the dissipation of mitochondrial membrane potential (MMP) and the release of cytochrome c into the cytosol.	Curcumin	0-8	sarcoglycan beta	Homo sapiens	30-33
24935585-6	2014	Curcumin-induced apoptosis of SGC-7901 cells was associated with the dissipation of mitochondrial membrane potential (MMP) and the release of cytochrome c into the cytosol.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	142-154
24935585-7	2014	Furthermore, the down-regulation of Bcl-2 and up-regulation of Bax that led to the cleavage of caspase-3 and increased cleaved PARP was observed in SGC-7901 cells treated with curcumin.	Curcumin	176-184	BCL2 apoptosis regulator	Homo sapiens	36-41
24935585-7	2014	Furthermore, the down-regulation of Bcl-2 and up-regulation of Bax that led to the cleavage of caspase-3 and increased cleaved PARP was observed in SGC-7901 cells treated with curcumin.	Curcumin	176-184	BCL2 associated X, apoptosis regulator	Homo sapiens	63-66
24935585-7	2014	Furthermore, the down-regulation of Bcl-2 and up-regulation of Bax that led to the cleavage of caspase-3 and increased cleaved PARP was observed in SGC-7901 cells treated with curcumin.	Curcumin	176-184	caspase 3	Homo sapiens	95-104
24935585-7	2014	Furthermore, the down-regulation of Bcl-2 and up-regulation of Bax that led to the cleavage of caspase-3 and increased cleaved PARP was observed in SGC-7901 cells treated with curcumin.	Curcumin	176-184	sarcoglycan beta	Homo sapiens	148-151
24935585-8	2014	Therefore, curcumin-induced apoptosis of SGC-7901 cells might be mediated through the mitochondria pathway, which gives the rationale for in vivo studies on the utilization of curcumin as a potential cancer therapeutic compound.	Curcumin	11-19	sarcoglycan beta	Homo sapiens	41-44
24935585-8	2014	Therefore, curcumin-induced apoptosis of SGC-7901 cells might be mediated through the mitochondria pathway, which gives the rationale for in vivo studies on the utilization of curcumin as a potential cancer therapeutic compound.	Curcumin	176-184	sarcoglycan beta	Homo sapiens	41-44
24528023-0	2014	Curcumin and its analogues (PGV-0 and PGV-1) enhance sensitivity of resistant MCF-7 cells to doxorubicin through inhibition of HER2 and NF-kB activation.	Curcumin	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	127-131
24528023-4	2014	The present study aimed to explore the effects of curcumin, PGV-0, and PGV-1 singly and in combination with doxorubicin on MCF-7/Dox cells featuring over-expression of HER2.	Curcumin	50-58	erb-b2 receptor tyrosine kinase 2	Homo sapiens	168-172
24528023-9	2014	Molecular docking of curcumin, PGV-0, and PGV-1 demonstrated high affinity to HER2 at ATP binding site.	Curcumin	21-29	erb-b2 receptor tyrosine kinase 2	Homo sapiens	78-82
24528023-11	2014	These findings suggested that curcumin, PGV-0 and PGV-1 enhance the Dox cytotoxicity to MCF-7 cells through inhibition of HER2 activity and NF-kB activation.	Curcumin	30-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	122-126
24360557-0	2014	Synthesis and evaluation of curcumin derivatives toward an inhibitor of beta-site amyloid precursor protein cleaving enzyme 1.	Curcumin	28-36	beta-secretase 1	Homo sapiens	72-125
24360557-1	2014	To research a new non-peptidyl inhibitor of beta-site amyloid precursor protein cleaving enzyme 1, we focused on the curcumin framework, two phenolic groups combined with an sp2 carbon spacer for low-molecular and high lipophilicity.	Curcumin	117-125	beta-secretase 1	Homo sapiens	44-97
24052408-3	2014	Here we report that two ROS generating phytochemicals, hydroxychavicol and curcumin synergize in leukemic cells in inducing enhanced apoptosis by independently activating both mitogen activated protein kinase (MAPK) (JNK and P(38)) and mTOR pathways.	Curcumin	75-83	mitogen-activated protein kinase 8	Homo sapiens	217-220
24052408-3	2014	Here we report that two ROS generating phytochemicals, hydroxychavicol and curcumin synergize in leukemic cells in inducing enhanced apoptosis by independently activating both mitogen activated protein kinase (MAPK) (JNK and P(38)) and mTOR pathways.	Curcumin	75-83	mitogen-activated protein kinase 14	Homo sapiens	225-230
24052408-3	2014	Here we report that two ROS generating phytochemicals, hydroxychavicol and curcumin synergize in leukemic cells in inducing enhanced apoptosis by independently activating both mitogen activated protein kinase (MAPK) (JNK and P(38)) and mTOR pathways.	Curcumin	75-83	mechanistic target of rapamycin kinase	Homo sapiens	236-240
24935377-7	2014	Curcumin at 2.5-10 muM had no evident toxicity against RCC cells, but inhibited cell migration in a concentration-dependent manner.	Curcumin	0-8	latexin	Homo sapiens	19-22
25422208-0	2014	Curcumin-loaded PLGA nanoparticles conjugated with anti- P-glycoprotein antibody to overcome multidrug resistance.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	57-71
24528086-4	2014	MATERIALS AND METHODS: In this study in vitro cytotoxicity of Curcumin was measured by MTT assay and apoptotic effects were assessed by annexin V/PI, DAPI staining, cell cycle analysis, measurement of caspase activity and PARP cleavage.	Curcumin	62-70	poly(ADP-ribose) polymerase 1	Homo sapiens	222-226
24606473-4	2014	Curcumin inhibited HDACs, HPV expression and differentially increased acetylation and up-regulation of p53 in SiHa and SiHaR, leading to cell cycle arrest at G1-S phase.	Curcumin	0-8	tumor protein p53	Homo sapiens	103-106
24870723-3	2014	MATERIALS AND METHODS: SKOV3 ovarian cancer cells were treated with curcumin (10-60 muM) and miR-9 expression, cell proliferation, and apoptosis were assessed.	Curcumin	68-76	latexin	Homo sapiens	84-87
24870723-5	2014	Phosphorylation of Akt and forkhead box protein O1 (FOXO1) was measured in cells with miR-9 overexpression or curcumin treatment.	Curcumin	110-118	AKT serine/threonine kinase 1	Homo sapiens	19-22
24870723-5	2014	Phosphorylation of Akt and forkhead box protein O1 (FOXO1) was measured in cells with miR-9 overexpression or curcumin treatment.	Curcumin	110-118	forkhead box O1	Homo sapiens	27-50
24870723-5	2014	Phosphorylation of Akt and forkhead box protein O1 (FOXO1) was measured in cells with miR-9 overexpression or curcumin treatment.	Curcumin	110-118	forkhead box O1	Homo sapiens	52-57
24870723-9	2014	Western blot analysis showed that both miR-9 overexpression and curcumin similarly caused a significant (p&lt;0.05) decline in the phosphorylation of Akt and FOXO1, compared to untreated cells.	Curcumin	64-72	AKT serine/threonine kinase 1	Homo sapiens	150-153
24870723-9	2014	Western blot analysis showed that both miR-9 overexpression and curcumin similarly caused a significant (p&lt;0.05) decline in the phosphorylation of Akt and FOXO1, compared to untreated cells.	Curcumin	64-72	forkhead box O1	Homo sapiens	158-163
24870723-10	2014	CONCLUSIONS: The present study provided evidence that curcumin exerts its cytotoxic effects against SKOV3 ovarian cancer cells largely through upregulation of miR-9 and subsequent modulation of Akt/FOXO1 axis.	Curcumin	54-62	AKT serine/threonine kinase 1	Homo sapiens	194-197
24870723-10	2014	CONCLUSIONS: The present study provided evidence that curcumin exerts its cytotoxic effects against SKOV3 ovarian cancer cells largely through upregulation of miR-9 and subsequent modulation of Akt/FOXO1 axis.	Curcumin	54-62	forkhead box O1	Homo sapiens	198-203
25105137-5	2014	In the present study, it was investigated whether neurite outgrowth defects could be rescued by curcumin and resveratrol, which are SMN-inducing polyphenols, having HDAC inhibition activity.	Curcumin	96-104	survival of motor neuron 1, telomeric	Rattus norvegicus	132-135
25157362-0	2014	Synthesis, characterization and in vitro anticancer activity of C-5 curcumin analogues with potential to inhibit TNF-alpha-induced NF-kappaB activation.	Curcumin	68-76	tumor necrosis factor	Homo sapiens	113-122
25105137-6	2014	According to our results, although curcumin and resveratrol failed to restore the neurite outgrowth defects, the SMN protein was found to be necessary for the neurite-promoting activity of curcumin in neuron-like PC12 cells.	Curcumin	189-197	survival of motor neuron 1, telomeric	Rattus norvegicus	113-116
24596618-5	2014	Curcumin inhibited intracellular Ca(2+) influx via phospholipase Cgamma1 (PLCgamma1) activation and the phosphorylation of mitogen-activated protein kinases (MAPKs) and the nuclear factor-kappaB (NF-kappaB) pathway.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	173-194
24280069-3	2014	Biological data revealed that as much as 1 muM curcumin 1 exhibited anticancer activity and almost 100% cell kill was noted at 10 muM on two out of four cell lines; while curcumin mono-glucuronide 2 as well as di-glucuronide 3 displayed no suppression of cell proliferation.	Curcumin	47-55	latexin	Homo sapiens	43-46
24280069-3	2014	Biological data revealed that as much as 1 muM curcumin 1 exhibited anticancer activity and almost 100% cell kill was noted at 10 muM on two out of four cell lines; while curcumin mono-glucuronide 2 as well as di-glucuronide 3 displayed no suppression of cell proliferation.	Curcumin	47-55	latexin	Homo sapiens	130-133
24280069-3	2014	Biological data revealed that as much as 1 muM curcumin 1 exhibited anticancer activity and almost 100% cell kill was noted at 10 muM on two out of four cell lines; while curcumin mono-glucuronide 2 as well as di-glucuronide 3 displayed no suppression of cell proliferation.	Curcumin	171-179	latexin	Homo sapiens	43-46
24596618-5	2014	Curcumin inhibited intracellular Ca(2+) influx via phospholipase Cgamma1 (PLCgamma1) activation and the phosphorylation of mitogen-activated protein kinases (MAPKs) and the nuclear factor-kappaB (NF-kappaB) pathway.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	196-205
24247158-0	2014	Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	104-107
25118487-3	2014	In this study, the authors demonstrated that curcumin induced human SKOV3 cell apoptosis and explored the underlying mechanism concerning Rho A/Rho-kinase pathway.	Curcumin	45-53	ras homolog family member A	Homo sapiens	138-143
25118487-10	2014	Curcumin also activated the expression of Rho A and Rho-kinase in a dose-dependent effect.	Curcumin	0-8	ras homolog family member A	Homo sapiens	42-47
25431606-0	2014	Curcumin Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm by Inhibition of Inflammatory Response and ERK Signaling Pathways.	Curcumin	0-8	mitogen-activated protein kinase 1	Mus musculus	112-115
25431606-14	2014	These results suggested that curcumin can inhibit the AngII-induced AAA in ApoE(-/-) mice, whose mechanisms include the curcumin anti-inflammation, antioxidative stress, and downregulation of ERK signaling pathway.	Curcumin	29-37	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	54-59
25431606-14	2014	These results suggested that curcumin can inhibit the AngII-induced AAA in ApoE(-/-) mice, whose mechanisms include the curcumin anti-inflammation, antioxidative stress, and downregulation of ERK signaling pathway.	Curcumin	29-37	apolipoprotein E	Mus musculus	75-79
25431606-14	2014	These results suggested that curcumin can inhibit the AngII-induced AAA in ApoE(-/-) mice, whose mechanisms include the curcumin anti-inflammation, antioxidative stress, and downregulation of ERK signaling pathway.	Curcumin	29-37	mitogen-activated protein kinase 1	Mus musculus	192-195
25431606-14	2014	These results suggested that curcumin can inhibit the AngII-induced AAA in ApoE(-/-) mice, whose mechanisms include the curcumin anti-inflammation, antioxidative stress, and downregulation of ERK signaling pathway.	Curcumin	120-128	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	54-59
24725086-0	2014	Phosphatidylserine and curcumin act synergistically to down-regulate release of interleukin-1beta from lipopolysaccharide-stimulated cortical primary microglial cells.	Curcumin	23-31	interleukin 1 beta	Rattus norvegicus	80-97
24725086-9	2014	PS and curcumin inhibited the release of interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha induced by lipopolysaccharide.	Curcumin	7-15	interleukin 1 beta	Rattus norvegicus	41-63
24725086-9	2014	PS and curcumin inhibited the release of interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha induced by lipopolysaccharide.	Curcumin	7-15	interleukin 6	Rattus norvegicus	65-102
25118487-13	2014	The pro-apoptosis effect of curcumin is partly mediated via the activation of Rho A/Rho-kinase signal pathway.	Curcumin	28-36	ras homolog family member A	Homo sapiens	78-83
25556280-0	2014	Curcumin promotes the apoptosis of human endometrial carcinoma cells by downregulating the expression of androgen receptor through Wnt signal pathway.	Curcumin	0-8	androgen receptor	Homo sapiens	105-122
25556280-8	2014	rWnt3a partially cancelled the effects of curcumin on the proliferation and apoptosis of human endometrial carcinoma cells as well as the AR expression-downregulating effect of curcumin.	Curcumin	177-185	androgen receptor	Homo sapiens	138-140
25556280-9	2014	CONCLUSION: Curcumin inhibits the proliferation and apoptosis of human endometrial carcinoma cells by downregulating their AR expression through the Wnt signal pathway.	Curcumin	12-20	androgen receptor	Homo sapiens	123-125
24453488-2	2014	In this study, the cytotoxicity of different concentrations (5, 10, 25, 50, 75, and 100 muM) of curcumin dissolved in dimethyl sulfoxide was compared between MG-63 osteosarcoma and healthy human osteoblast cells.	Curcumin	96-104	latexin	Homo sapiens	88-91
24453488-5	2014	Therefore, this study showed that at the right concentrations (5 muM to 25 muM), curcumin, along with a proper nanoparticle drug delivery carrier, may selectively kill bone cancer cells over healthy bone cells.	Curcumin	81-89	latexin	Homo sapiens	65-68
24453488-5	2014	Therefore, this study showed that at the right concentrations (5 muM to 25 muM), curcumin, along with a proper nanoparticle drug delivery carrier, may selectively kill bone cancer cells over healthy bone cells.	Curcumin	81-89	latexin	Homo sapiens	75-78
24247158-2	2014	Our previous study showed that water-soluble PLGA curcumin nanoparticles (Cur-NPs) triggered apoptotic cell death through regulation of the function of MDR1 and the production of reactive oxygen species (ROS) in cisplatin-resistant human oral cancer CAR cells.	Curcumin	50-58	ATP binding cassette subfamily B member 1	Homo sapiens	152-156
24225136-2	2014	In this study, we evaluated the in vitro effects of two alkylphosphocholines (APCs, miltefosine and erufosine) and the polyphenolic compound curcumin on 5 human CTCL cell lines (Hut-78, HH, MJ, My-La CD4+ and My-La CD8+).	Curcumin	141-149	TSPY like 2	Homo sapiens	161-165
25272063-0	2014	Curcumin augments the efficacy of antitumor drugs used in leukemia by modulation of heat shock proteins via HDAC6.	Curcumin	0-8	histone deacetylase 6	Homo sapiens	108-113
25272063-7	2014	Overexpression of HSPs (27, 70, 90), HSF1, and HDAC6 in leukemia cells were down-regulated by curcumin, and the effects on HSPs 27and 70 were less than that on HSP 90.	Curcumin	94-102	histone deacetylase 6	Homo sapiens	47-52
25452269-9	2014	Curcumin treatment upregulated the expression of PPAR-gamma and downregulated the expression of p-Smad2/3.	Curcumin	0-8	SMAD family member 3	Rattus norvegicus	98-105
25452269-10	2014	These results suggest that curcumin treatment ameliorates renal fibrosis by reducing fibroblast proliferation and ECM accumulation mediated by PPAR-gamma and Smad-dependent TGF-beta1 signaling.	Curcumin	27-35	transforming growth factor, beta 1	Rattus norvegicus	173-182
24184124-6	2014	Our results demonstrated that raloxifen, tamoxifen, genistein and curcumin decreased DU145 and PC3 cell proliferation in a dose-dependent manner; in addition, all four compounds significantly decreased the detachment of cells seeded on laminin or fibronectin.	Curcumin	66-74	fibronectin 1	Homo sapiens	247-258
24173373-0	2014	Curcumin regulates the metabolism of low density lipoproteins by improving the C-to-U RNA editing efficiency of apolipoprotein B in primary rat hepatocytes.	Curcumin	0-8	apolipoprotein B	Rattus norvegicus	112-128
24173373-4	2014	In the present study, we analyzed whether curcumin is capable of regulating lipid metabolism by improving the level of apoB mRNA editing.	Curcumin	42-50	apolipoprotein B	Rattus norvegicus	119-123
24173373-7	2014	We demonstrated that curcumin concentrations up to 70 microM had no significant cytotoxic effects on primary rat hepatocytes at 24 h. At 15 microM, curcumin significantly increased the expression of APOBEC-1 mRNA and protein, and increased the editing level of apoB mRNA from 3.13 to 7.53%.	Curcumin	148-156	apolipoprotein B	Rattus norvegicus	261-265
24173373-9	2014	Our data suggested that curcumin at a concentration of 15 microM raised the level of apoB-48 and reduced the level of apoB-100 by increasing the expression of APOBEC-1 in primary rat hepatocytes; therefore, curcumin may be a novel preventative therapy for atherosclerosis.	Curcumin	24-32	apolipoprotein B	Rattus norvegicus	85-92
24173373-9	2014	Our data suggested that curcumin at a concentration of 15 microM raised the level of apoB-48 and reduced the level of apoB-100 by increasing the expression of APOBEC-1 in primary rat hepatocytes; therefore, curcumin may be a novel preventative therapy for atherosclerosis.	Curcumin	24-32	apolipoprotein B	Rattus norvegicus	118-126
24640977-4	2014	Preclinically, the first line of defense is behavior-lowering peripheral insulin resistance (e.g., physical exercise and a Mediterranean diet supplemented with foods rich in flavonoids, curcumin and omega-3 fatty acids).	Curcumin	186-194	insulin	Homo sapiens	73-80
23959480-0	2014	Curcumin induces osteosarcoma MG63 cells apoptosis via ROS/Cyto-C/Caspase-3 pathway.	Curcumin	0-8	caspase 3	Homo sapiens	66-75
23888319-0	2014	Curcumin inhibits lung cancer progression and metastasis through induction of FOXO1.	Curcumin	0-8	forkhead box O1	Homo sapiens	78-83
23959480-5	2014	In addition, Western blotting detection suggested that curcumin of high concentrations can induce the release of Cyto-C and the activation of Caspase-3, and that ROS scavenger NAC apparently inhibits apoptosis protein release and activation, consequently slowing the curcumin-induced apoptosis.	Curcumin	55-63	caspase 3	Homo sapiens	142-151
23888319-3	2014	Our results found that curcumin inhibited cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1.	Curcumin	23-31	cyclin dependent kinase inhibitor 1A	Homo sapiens	152-155
24121531-1	2013	The natural product curcumin has been shown to play a role in preventing Abeta amyloid fibril formation.	Curcumin	20-28	amyloid beta precursor protein	Homo sapiens	73-78
23888319-4	2014	In addition, we showed that curcumin induced the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling.	Curcumin	28-36	forkhead box O1	Homo sapiens	63-86
23888319-4	2014	In addition, we showed that curcumin induced the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling.	Curcumin	28-36	forkhead box O1	Homo sapiens	88-93
23888319-4	2014	In addition, we showed that curcumin induced the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling.	Curcumin	28-36	mitogen-activated protein kinase 3	Homo sapiens	117-158
23888319-5	2014	These findings provide evidence for a mechanism that may contribute to the antineoplastic effects of curcumin and justify further work to explore potential roles for activators of FOXO1 in the prevention and treatment of lung cancer.	Curcumin	101-109	forkhead box O1	Homo sapiens	180-185
24428990-0	2014	[Curcumin reduces paraquat-induced oxidative injury in A549 cells by activation of the Nrf2-ARE pathway].	Curcumin	1-9	NFE2 like bZIP transcription factor 2	Homo sapiens	87-91
24428990-11	2014	CONCLUSION: Low-dose CU significantly reduces the PQ-induced oxidative damage in A549 cells in vitro by activation of the Nrf2-ARE pathway.	Curcumin	21-23	NFE2 like bZIP transcription factor 2	Homo sapiens	122-126
24121531-2	2013	This role could include chelation of transition metal ions such as Cu(2+), known to accelerate amyloid aggregation, and/or curcumin-binding directly to the Abeta protein.	Curcumin	123-131	amyloid beta precursor protein	Homo sapiens	156-161
24427321-11	2014	Curcumin may suppress GSTM5 expression to enhance the lethal effect of irinotecan on LOVO cells, and maybe their combination via the affection of PDI and PRDX4 to disturb the formation and reduction of disulfides results in inducing apoptosis of LOVO cell.	Curcumin	0-8	glutathione S-transferase mu 5	Homo sapiens	22-27
24364912-0	2013	Curcumin regulates gene expression of insulin like growth factor, B-cell CLL/lymphoma 2 and antioxidant enzymes in streptozotocin induced diabetic rats.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	66-87
24364912-9	2013	In addition, curcumin treated rats showed significant increase in gene expression of IGF-1, Bcl2, SOD and GST compare to non diabetic and diabetic untreated rats.	Curcumin	13-21	BCL2, apoptosis regulator	Rattus norvegicus	92-96
24364912-10	2013	CONCLUSION: Curcumin was antidiabetic therapy, induced hypoglycemia by up-regulation of IGF-1 gene and ameliorate the diabetes induced oxidative stress via increasing the availability of GSH, increasing the activities and gene expression of antioxidant enzymes and Bcl2.	Curcumin	12-20	BCL2, apoptosis regulator	Rattus norvegicus	265-269
24036260-9	2013	Findings in both in vitro and in vivo mechanistic studies are consistent with the supposition that the presently described liposomal formulation of curcumin inhibits tumor growth by blocking VEGF-induced STAT3 phosphorylation in tumor endothelium.	Curcumin	148-156	signal transducer and activator of transcription 3	Mus musculus	204-209
24330336-9	2013	RESULTS: Results of the manual patch clamp assay of HEK 293 cells clearly illustrated that our hybrid nanocurcumin formulation prevented the curcumin induced inhibition of hERG K+ channel at concentrations higher than the therapeutic concentrations of curcumin.	Curcumin	106-114	ETS transcription factor ERG	Homo sapiens	172-176
24330336-9	2013	RESULTS: Results of the manual patch clamp assay of HEK 293 cells clearly illustrated that our hybrid nanocurcumin formulation prevented the curcumin induced inhibition of hERG K+ channel at concentrations higher than the therapeutic concentrations of curcumin.	Curcumin	141-149	ETS transcription factor ERG	Homo sapiens	172-176
23632743-9	2013	The data indicated that inhibition of histone H3 acetylation with curcumin diminished BMP2-induced expression of GATA4 and MEF2C, suggesting that p300-mediated histone acetylation was essential for the regulation of GATA4 and MEF2C by BMP2 in H9c2 cells.	Curcumin	66-74	bone morphogenetic protein 2	Mus musculus	86-90
24236784-8	2013	We also found that curcumin inhibited doxorubicin-induced EMT by inhibiting the TGF-beta and PI3K/AKT signaling pathways.	Curcumin	19-27	transforming growth factor beta 1	Homo sapiens	80-88
24349037-14	2013	Western Blot analyses revealed that of these targets anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and proliferating cell nuclear antigen (PCNA) were significantly down-regulated in curcumin-treated tumors.	Curcumin	181-189	B cell leukemia/lymphoma 2	Mus musculus	68-89
24349037-14	2013	Western Blot analyses revealed that of these targets anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and proliferating cell nuclear antigen (PCNA) were significantly down-regulated in curcumin-treated tumors.	Curcumin	181-189	B cell leukemia/lymphoma 2	Mus musculus	91-96
24236784-0	2013	Curcumin suppresses doxorubicin-induced epithelial-mesenchymal transition via the inhibition of TGF-beta and PI3K/AKT signaling pathways in triple-negative breast cancer cells.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	96-104
24236784-7	2013	Curcumin reversed doxorubicin-induced morphological changes, inhibited doxorubicin-induced downregulation of E-cadherin expressions, and inhibited doxorubicin-induced upregulation of vimentin expression.	Curcumin	0-8	cadherin 1	Homo sapiens	109-119
23387971-6	2013	When compared to curcumin dissolved in DMSO, dendrimer-curcumin conjugate dissolved in water was significantly more effective in inducing cytotoxicity, as measured by the MTT assay and effectively induced cellular apoptosis measured by caspase-3 activation.	Curcumin	55-63	caspase 3	Homo sapiens	236-245
23632743-6	2013	Quantitative real-time RT-PCR analysis showed that curcumin substantially inhibited both AdBMP2-induced and basal expression levels of cardiac transcription factors GATA4 and MEF2C, but not Tbx5.	Curcumin	51-59	GATA binding protein 4	Rattus norvegicus	165-170
23632743-7	2013	Similarly, chromatin immunoprecipitation (ChIP) analysis showed that curcumin inhibited both AdBMP2-induced and basal histone H3 acetylation levels in the promoter regions of GATA4 and MEF2C, but not of Tbx5.	Curcumin	69-77	GATA binding protein 4	Rattus norvegicus	175-180
23632743-9	2013	The data indicated that inhibition of histone H3 acetylation with curcumin diminished BMP2-induced expression of GATA4 and MEF2C, suggesting that p300-mediated histone acetylation was essential for the regulation of GATA4 and MEF2C by BMP2 in H9c2 cells.	Curcumin	66-74	GATA binding protein 4	Mus musculus	113-118
23632743-9	2013	The data indicated that inhibition of histone H3 acetylation with curcumin diminished BMP2-induced expression of GATA4 and MEF2C, suggesting that p300-mediated histone acetylation was essential for the regulation of GATA4 and MEF2C by BMP2 in H9c2 cells.	Curcumin	66-74	myocyte enhancer factor 2C	Mus musculus	123-128
23632743-9	2013	The data indicated that inhibition of histone H3 acetylation with curcumin diminished BMP2-induced expression of GATA4 and MEF2C, suggesting that p300-mediated histone acetylation was essential for the regulation of GATA4 and MEF2C by BMP2 in H9c2 cells.	Curcumin	66-74	GATA binding protein 4	Mus musculus	216-221
23632743-9	2013	The data indicated that inhibition of histone H3 acetylation with curcumin diminished BMP2-induced expression of GATA4 and MEF2C, suggesting that p300-mediated histone acetylation was essential for the regulation of GATA4 and MEF2C by BMP2 in H9c2 cells.	Curcumin	66-74	myocyte enhancer factor 2C	Mus musculus	226-231
23632743-9	2013	The data indicated that inhibition of histone H3 acetylation with curcumin diminished BMP2-induced expression of GATA4 and MEF2C, suggesting that p300-mediated histone acetylation was essential for the regulation of GATA4 and MEF2C by BMP2 in H9c2 cells.	Curcumin	66-74	bone morphogenetic protein 2	Mus musculus	235-239
23954472-7	2013	Pretreatment with sulforaphane and curcumin also inhibited the OC differentiation by activating Nrf2 in part.	Curcumin	35-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-100
23998949-0	2013	Targeting EP4 by curcumin through cross talks of AMP-dependent kinase alpha and p38 mitogen-activated protein kinase signaling: the role of PGC-1alpha and Sp1.	Curcumin	17-25	mitogen-activated protein kinase 14	Homo sapiens	80-83
23998949-5	2013	Blockade of AMP-dependent kinase (AMPK), and p38 MAPK by either chemical inhibitors or siRNAs antagonized the inhibitory effect of curcumin on EP4 expression, which was reversed by metformin, an activator of AMPK.	Curcumin	131-139	mitogen-activated protein kinase 14	Homo sapiens	45-48
23998949-6	2013	Curcumin induced PGC-1alpha protein that was blocked by compound C and SB239063.	Curcumin	0-8	PPARG coactivator 1 alpha	Homo sapiens	17-27
23998949-7	2013	Silencing of PGC-1alpha reversed the effect of curcumin on EP4 protein.	Curcumin	47-55	PPARG coactivator 1 alpha	Homo sapiens	13-23
23998949-11	2013	Interestingly, overexpression of PGC-1alpha further enhanced the inhibitory effect of curcumin on Sp1 protein expression that was blocked by SB239063.	Curcumin	86-94	PPARG coactivator 1 alpha	Homo sapiens	33-43
23998949-12	2013	In conclusion, this study shows that curcumin inhibits EP4 gene expression dependent of AMPKalpha and p38 MAPK activation, this leads to reduction of Sp1 protein and binding to specific area in the EP4 gene promoter.	Curcumin	37-45	mitogen-activated protein kinase 14	Homo sapiens	102-105
24165291-8	2013	Curcumin suppressed cell proliferation, colony formation, migration, and induced apoptosis which was mediated partly through the mitochondrial pathway after an increase in the ratio of Bax to Bcl2.	Curcumin	0-8	B cell leukemia/lymphoma 2	Mus musculus	192-196
24363979-0	2013	Curcumin in VIP-targeted sterically stabilized phospholipid nanomicelles: a novel therapeutic approach for breast cancer and breast cancer stem cells.	Curcumin	0-8	vasoactive intestinal peptide	Homo sapiens	12-15
23880291-0	2013	SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury.	Curcumin	20-28	sirtuin 1	Rattus norvegicus	0-5
23880291-3	2013	Curcumin (Cur) is a strong natural antioxidant and is the active component in Curcuma longa; Cur has protective effects against IRI and may regulate the activity of SIRT1.	Curcumin	0-8	sirtuin 1	Rattus norvegicus	165-170
24184481-12	2013	However, MCP-1 and F4/80 mRNA expression levels were significantly attenuated by curcumin administration in downhill running mice.	Curcumin	81-89	mast cell protease 1	Mus musculus	9-14
24157330-4	2013	Here, we demonstrated that curcumin inhibited formyl-methionyl-leucyl-phenylalanine (fMLP)- or lipopolysaccharide (LPS)-induced suppression of human neutrophil apoptosis.	Curcumin	27-35	formyl peptide receptor 1	Homo sapiens	85-89
24157330-6	2013	Using an antibody array approach, curcumin was found to inhibit LPS-induced cytokine production, including MIP-1alpha, MIP-1beta, IL-6, IL-8 (CXCL-8) and GRO-alpha.	Curcumin	34-42	interleukin 6	Homo sapiens	130-134
24157330-6	2013	Using an antibody array approach, curcumin was found to inhibit LPS-induced cytokine production, including MIP-1alpha, MIP-1beta, IL-6, IL-8 (CXCL-8) and GRO-alpha.	Curcumin	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
24157330-6	2013	Using an antibody array approach, curcumin was found to inhibit LPS-induced cytokine production, including MIP-1alpha, MIP-1beta, IL-6, IL-8 (CXCL-8) and GRO-alpha.	Curcumin	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	142-148
24157330-7	2013	The inhibitory effect of curcumin on IL-8 production was confirmed by ELISA.	Curcumin	25-33	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
24527187-8	2013	RESULTS: High-dose curcumin group showed significantly lower osteocalcin, alkaline phosphatase, and the telopeptide fragment of type I collagen C-terminus concentration at 4 and 8 weeks compared with the untreated OVX group as well as low-dose curcumin group.	Curcumin	19-27	bone gamma-carboxyglutamate protein	Rattus norvegicus	61-72
23430567-0	2013	Curcumin prevents liver fat accumulation and serum fetuin-A increase in rats fed a high-fat diet.	Curcumin	0-8	alpha-2-HS-glycoprotein	Rattus norvegicus	51-59
23430567-4	2013	In this study, we investigated the effect of curcumin treatment on serum fetuin-A levels as well as hepatic lipids and prooxidant-antioxidant status in rats fed a high-fat diet (HFD).	Curcumin	45-53	alpha-2-HS-glycoprotein	Rattus norvegicus	73-81
23430567-10	2013	Curcumin treatment appeared to be effective in reducing liver triglycerides and serum fetuin-A levels.	Curcumin	0-8	alpha-2-HS-glycoprotein	Rattus norvegicus	86-94
23430567-11	2013	These findings suggest that the reduction of fetuin-A may contribute to the beneficial effects of curcumin in the pathogenesis of obesity.	Curcumin	98-106	alpha-2-HS-glycoprotein	Rattus norvegicus	45-53
24064724-3	2013	We identified that curcumin interrupts wnt signaling by decreasing beta-catenin activity, which in turn suppresses the expression of beta-catenin target genes (c-myc, VEGF and cyclin D1).	Curcumin	19-27	vascular endothelial growth factor A	Homo sapiens	167-171
23794119-13	2013	Curcumin effect was mediated through activation of TNFR, CASP 8, CASP3, BID, BAX, and down-regulation of NFkappaB, NDRG 1, and BCL2L10 genes.	Curcumin	0-8	caspase 3	Homo sapiens	65-70
23794119-13	2013	Curcumin effect was mediated through activation of TNFR, CASP 8, CASP3, BID, BAX, and down-regulation of NFkappaB, NDRG 1, and BCL2L10 genes.	Curcumin	0-8	BH3 interacting domain death agonist	Homo sapiens	72-75
23794119-13	2013	Curcumin effect was mediated through activation of TNFR, CASP 8, CASP3, BID, BAX, and down-regulation of NFkappaB, NDRG 1, and BCL2L10 genes.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	77-80
23794119-13	2013	Curcumin effect was mediated through activation of TNFR, CASP 8, CASP3, BID, BAX, and down-regulation of NFkappaB, NDRG 1, and BCL2L10 genes.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	105-113
23794119-13	2013	Curcumin effect was mediated through activation of TNFR, CASP 8, CASP3, BID, BAX, and down-regulation of NFkappaB, NDRG 1, and BCL2L10 genes.	Curcumin	0-8	BCL2 like 10	Homo sapiens	127-134
24369238-0	2013	[Curcumin inhibits HeLa cell invasion and migration by decreasing inducible nitric oxide synthase].	Curcumin	1-9	nitric oxide synthase 2	Homo sapiens	66-97
24369238-6	2013	Curcumin inhibited the invasion and migration of HeLa cells by increasing E-cad expression and decreasing MMP-9 expression, and also decreased the expression level of iNOS and NO production in the cells.	Curcumin	0-8	cadherin 1	Homo sapiens	74-79
24369238-6	2013	Curcumin inhibited the invasion and migration of HeLa cells by increasing E-cad expression and decreasing MMP-9 expression, and also decreased the expression level of iNOS and NO production in the cells.	Curcumin	0-8	nitric oxide synthase 2	Homo sapiens	167-171
24369238-7	2013	CONCLUSION: Curcumin inhibits the invasion and migration of HeLa cells by decreasing the expression of iNOS.	Curcumin	12-20	nitric oxide synthase 2	Homo sapiens	103-107
24369247-5	2013	Treatment of Jurkat cells with 25, 50, and 75 micromol/L curcumin resulted in a concentration-dependent increase of JNK and p-JNK expressions (P&lt;0.01) without significantly affecting the expressions of ERK1/2 and P38 MAPK or the activity of MMP-2 and MMP-9.	Curcumin	57-65	mitogen-activated protein kinase 8	Homo sapiens	116-119
24369247-5	2013	Treatment of Jurkat cells with 25, 50, and 75 micromol/L curcumin resulted in a concentration-dependent increase of JNK and p-JNK expressions (P&lt;0.01) without significantly affecting the expressions of ERK1/2 and P38 MAPK or the activity of MMP-2 and MMP-9.	Curcumin	57-65	mitogen-activated protein kinase 8	Homo sapiens	126-129
24369247-5	2013	Treatment of Jurkat cells with 25, 50, and 75 micromol/L curcumin resulted in a concentration-dependent increase of JNK and p-JNK expressions (P&lt;0.01) without significantly affecting the expressions of ERK1/2 and P38 MAPK or the activity of MMP-2 and MMP-9.	Curcumin	57-65	mitogen-activated protein kinase 3	Homo sapiens	205-211
24369247-6	2013	CONCLUSION: Curcumin within the concentration range of 6.25-25.00 micromol/L can induce apoptosis and cell cycle arrest of Jurkat cells, the mechanism of which might involve the activation of JNK pathway but not the MMPs.	Curcumin	12-20	mitogen-activated protein kinase 8	Homo sapiens	192-195
24134851-6	2013	Curcumin counteracted both deleterious effects of Abeta; the initial synaptic dysfunction and the later neuronal death.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	50-55
24134851-8	2013	Curcumin-mediated attenuation of Abeta-induced synaptic dysfunction involved regulation of synaptic proteins, namely phospho-CaMKII and phospho-synapsin I.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	33-38
24200537-0	2013	Liposomal-formulated curcumin [Lipocurc ] targeting HDAC (histone deacetylase) prevents apoptosis and improves motor deficits in Park 7 (DJ-1)-knockout rat model of Parkinson"s disease: implications for epigenetics-based nanotechnology-driven drug platform.	Curcumin	21-29	Parkinsonism associated deglycase	Rattus norvegicus	129-135
24199833-0	2013	Synthesis and characterization of fac-[M(CO)3(P)(OO)] and cis-trans-[M(CO)2(P)2(OO)] complexes (M = Re, (99m)Tc) with acetylacetone and curcumin as OO donor bidentate ligands.	Curcumin	136-144	FA complementation group C	Homo sapiens	34-37
23661584-0	2013	Tumor necrosis factor alpha induces Warburg-like metabolism and is reversed by anti-inflammatory curcumin in breast epithelial cells.	Curcumin	97-105	tumor necrosis factor	Homo sapiens	0-27
23881281-3	2013	Treatment of AGS and HT-29 cells with curcumin enhanced the cleavage of procaspase-3, -7, -8 and -9.	Curcumin	38-46	caspase 3	Homo sapiens	72-99
23881281-4	2013	Meanwhile, curcumin induced endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells.	Curcumin	11-19	DNA damage inducible transcript 3	Homo sapiens	125-174
23881281-4	2013	Meanwhile, curcumin induced endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells.	Curcumin	11-19	DNA damage inducible transcript 3	Homo sapiens	176-180
23881281-4	2013	Meanwhile, curcumin induced endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells.	Curcumin	11-19	mitogen-activated protein kinase 8	Homo sapiens	202-205
23881281-4	2013	Meanwhile, curcumin induced endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells.	Curcumin	11-19	cytochrome c, somatic	Homo sapiens	254-266
23881281-4	2013	Meanwhile, curcumin induced endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells.	Curcumin	11-19	BCL2 apoptosis regulator	Homo sapiens	280-285
23881281-5	2013	Overexpression of bax, total JNK, phospho-FADD and total FADD were also observed in curcumin-treated HT-29 cells.	Curcumin	84-92	BCL2 associated X, apoptosis regulator	Homo sapiens	18-21
23881281-5	2013	Overexpression of bax, total JNK, phospho-FADD and total FADD were also observed in curcumin-treated HT-29 cells.	Curcumin	84-92	mitogen-activated protein kinase 8	Homo sapiens	29-32
23881281-9	2013	siRNA to CHOP markedly reduced curcumin-induced apoptosis.	Curcumin	31-39	DNA damage inducible transcript 3	Homo sapiens	9-13
24134840-0	2013	MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells.	Curcumin	19-27	mitogen-activated protein kinase 8	Homo sapiens	37-40
24134840-0	2013	MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells.	Curcumin	19-27	forkhead box O3	Homo sapiens	53-59
24134840-5	2013	c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation.	Curcumin	52-60	mitogen-activated protein kinase 8	Homo sapiens	0-31
24134840-5	2013	c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation.	Curcumin	52-60	mitogen-activated protein kinase 8	Homo sapiens	33-36
24134840-5	2013	c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation.	Curcumin	52-60	mitogen-activated protein kinase 8	Homo sapiens	156-159
24134840-5	2013	c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation.	Curcumin	139-147	mitogen-activated protein kinase 8	Homo sapiens	0-31
24134840-5	2013	c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation.	Curcumin	139-147	mitogen-activated protein kinase 8	Homo sapiens	33-36
24134840-5	2013	c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation.	Curcumin	139-147	mitogen-activated protein kinase 8	Homo sapiens	156-159
24134840-6	2013	Further, curcumin induced Foxo3 nuclear translocation and Bim-1 (Foxo3 target gene) expression in melanoma cells, such an effect by curcumin was inhibited by MST1 RNAi.	Curcumin	9-17	forkhead box O3	Homo sapiens	26-31
24134840-6	2013	Further, curcumin induced Foxo3 nuclear translocation and Bim-1 (Foxo3 target gene) expression in melanoma cells, such an effect by curcumin was inhibited by MST1 RNAi.	Curcumin	9-17	forkhead box O3	Homo sapiens	65-70
24134840-7	2013	In conclusion, we suggested that MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells.	Curcumin	52-60	mitogen-activated protein kinase 8	Homo sapiens	70-73
24134840-7	2013	In conclusion, we suggested that MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells.	Curcumin	52-60	forkhead box O3	Homo sapiens	86-92
24025356-3	2013	The role of ERK1/2 signaling is clearly complex, for example as shown by the Koumenis group where inhibition of radiation-induced ERK1/2 signaling caused radiosensitization, whereas inhibition of curcumin-hyper-stimulated ERK1/2 signaling reduced radiosensitivity.	Curcumin	196-204	mitogen-activated protein kinase 3	Homo sapiens	12-18
24200537-0	2013	Liposomal-formulated curcumin [Lipocurc ] targeting HDAC (histone deacetylase) prevents apoptosis and improves motor deficits in Park 7 (DJ-1)-knockout rat model of Parkinson"s disease: implications for epigenetics-based nanotechnology-driven drug platform.	Curcumin	21-29	Parkinsonism associated deglycase	Rattus norvegicus	137-141
23376509-7	2013	Curcumin significantly reduced malondialdehyde and nitric oxide levels, and enchanced reduced glutathione levels and catalase, superoxide dismutase, and glutathione S-transferase enzymes activities in the livers and kidneys of BDL group.	Curcumin	0-8	catalase	Rattus norvegicus	117-125
23376509-8	2013	Curcumin treatment in BDL group was found to decrease tumor necrosis factor-alpha levels in the livers of rats.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	54-81
24057865-4	2013	Another reagent, curcumin, has been shown to inhibit mammalian target of rapamycin (mTOR) signal pathway in tumor cells.	Curcumin	17-25	mechanistic target of rapamycin kinase	Homo sapiens	53-82
24057865-4	2013	Another reagent, curcumin, has been shown to inhibit mammalian target of rapamycin (mTOR) signal pathway in tumor cells.	Curcumin	17-25	mechanistic target of rapamycin kinase	Homo sapiens	84-88
24057865-9	2013	The D942 and curcumin induced autophagy in cardiomyocytes through activating AMPK pathway or inhibiting mTOR signaling.	Curcumin	13-21	mechanistic target of rapamycin kinase	Homo sapiens	104-108
24229684-0	2013	Reversion effects of curcumin on multidrug resistance of MNNG/HOS human osteosarcoma cells in vitro and in vivo through regulation of P-glycoprotein.	Curcumin	21-29	ATP binding cassette subfamily B member 1	Homo sapiens	134-148
23846485-5	2013	Immunoblotting, RNA interference, and use of chemical inhibitors of TRAIL-activate signaling revealed differential effects of curcumin on the expression of Mcl-1 and activities of ERK and Akt.	Curcumin	126-134	AKT serine/threonine kinase 1	Homo sapiens	188-191
24229684-9	2013	Real-time PCR and Western blotting assays demonstrated that curcumin down-regulated P-gp expression of MNNG/HOS/MTX cells.	Curcumin	60-68	ATP binding cassette subfamily B member 1	Homo sapiens	84-88
24229684-10	2013	Rh123 transport test showed that curcumin inhibited the transport function of P-gp in vitro.	Curcumin	33-41	ATP binding cassette subfamily B member 1	Homo sapiens	78-82
24229684-12	2013	CONCLUSION: Down-regulation of P-gp and inhibition of the function of P-gp efflux pump may contribute to MDR reversion induced by curcumin in vitro and in vivo.	Curcumin	130-138	ATP binding cassette subfamily B member 1	Homo sapiens	31-35
24229684-12	2013	CONCLUSION: Down-regulation of P-gp and inhibition of the function of P-gp efflux pump may contribute to MDR reversion induced by curcumin in vitro and in vivo.	Curcumin	130-138	ATP binding cassette subfamily B member 1	Homo sapiens	70-74
23846485-0	2013	Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	18-23
23846485-2	2013	Natural compound curcumin could potentially sensitize resistant cancer cells to TRAIL.	Curcumin	17-25	TNF superfamily member 10	Homo sapiens	80-85
23846485-3	2013	We found that the combination of TRAIL with curcumin can synergistically induces apoptosis in three TRAIL-resistant breast cancer cell lines.	Curcumin	44-52	TNF superfamily member 10	Homo sapiens	100-105
24228095-9	2013	5-FU induced dramatic increase of serum endotoxin, D-lactate and D-Amino-Acid Oxidase (DAO) that were significantly reversed by Curcumin treatment.	Curcumin	128-136	D-amino-acid oxidase	Rattus norvegicus	65-85
23846485-4	2013	The mechanism behind this synergistic cell death was investigated by examining an effect of curcumin on the expression and activation of TRAIL-associated cell death proteins.	Curcumin	92-100	TNF superfamily member 10	Homo sapiens	137-142
23846485-5	2013	Immunoblotting, RNA interference, and use of chemical inhibitors of TRAIL-activate signaling revealed differential effects of curcumin on the expression of Mcl-1 and activities of ERK and Akt.	Curcumin	126-134	TNF superfamily member 10	Homo sapiens	68-73
23846485-5	2013	Immunoblotting, RNA interference, and use of chemical inhibitors of TRAIL-activate signaling revealed differential effects of curcumin on the expression of Mcl-1 and activities of ERK and Akt.	Curcumin	126-134	mitogen-activated protein kinase 1	Homo sapiens	180-183
23954730-0	2013	Free and nanoencapsulated curcumin suppress beta-amyloid-induced cognitive impairments in rats: involvement of BDNF and Akt/GSK-3beta signaling pathway.	Curcumin	26-34	AKT serine/threonine kinase 1	Rattus norvegicus	120-123
23954767-0	2013	Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
23954767-7	2013	Both 0.5 muM C3 and 5 muM curcumin induced Nrf2 nuclear translocation and Nrf2 target genes transcription similarly.	Curcumin	26-34	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
23954767-7	2013	Both 0.5 muM C3 and 5 muM curcumin induced Nrf2 nuclear translocation and Nrf2 target genes transcription similarly.	Curcumin	26-34	NFE2 like bZIP transcription factor 2	Homo sapiens	74-78
23954767-8	2013	Experiments using Nrf2 siRNA showed that the protective effects of curcumin and C3 were eliminated by Nrf2 knockdown.	Curcumin	67-75	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
23954767-8	2013	Experiments using Nrf2 siRNA showed that the protective effects of curcumin and C3 were eliminated by Nrf2 knockdown.	Curcumin	67-75	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
23954767-9	2013	Additionally, both curcumin and C3 activated the PI3/Akt pathway, however, Nrf2 activation was independent of this pathway, and therefore, we hypothesized that both curcumin and C3 activated phase II enzymes via directly disrupting the Nrf2/Keap1 complex and promoting Nrf2"s nuclear translocation.	Curcumin	19-27	AKT serine/threonine kinase 1	Homo sapiens	53-56
23954767-9	2013	Additionally, both curcumin and C3 activated the PI3/Akt pathway, however, Nrf2 activation was independent of this pathway, and therefore, we hypothesized that both curcumin and C3 activated phase II enzymes via directly disrupting the Nrf2/Keap1 complex and promoting Nrf2"s nuclear translocation.	Curcumin	165-173	AKT serine/threonine kinase 1	Homo sapiens	53-56
23954767-9	2013	Additionally, both curcumin and C3 activated the PI3/Akt pathway, however, Nrf2 activation was independent of this pathway, and therefore, we hypothesized that both curcumin and C3 activated phase II enzymes via directly disrupting the Nrf2/Keap1 complex and promoting Nrf2"s nuclear translocation.	Curcumin	165-173	NFE2 like bZIP transcription factor 2	Homo sapiens	75-79
23954767-9	2013	Additionally, both curcumin and C3 activated the PI3/Akt pathway, however, Nrf2 activation was independent of this pathway, and therefore, we hypothesized that both curcumin and C3 activated phase II enzymes via directly disrupting the Nrf2/Keap1 complex and promoting Nrf2"s nuclear translocation.	Curcumin	165-173	NFE2 like bZIP transcription factor 2	Homo sapiens	236-240
23954767-9	2013	Additionally, both curcumin and C3 activated the PI3/Akt pathway, however, Nrf2 activation was independent of this pathway, and therefore, we hypothesized that both curcumin and C3 activated phase II enzymes via directly disrupting the Nrf2/Keap1 complex and promoting Nrf2"s nuclear translocation.	Curcumin	165-173	kelch like ECH associated protein 1	Homo sapiens	241-246
23954767-9	2013	Additionally, both curcumin and C3 activated the PI3/Akt pathway, however, Nrf2 activation was independent of this pathway, and therefore, we hypothesized that both curcumin and C3 activated phase II enzymes via directly disrupting the Nrf2/Keap1 complex and promoting Nrf2"s nuclear translocation.	Curcumin	165-173	NFE2 like bZIP transcription factor 2	Homo sapiens	236-240
23872022-1	2013	The interaction of diacetylcurcumin (DAC), as a novel synthetic derivative of curcumin, with bovine beta-casein (an abundant milk protein that is highly amphiphilic and self assembles into stable micellar nanoparticles in aqueous solution) was investigated using fluorescence quenching experiments, Forster energy transfer measurements and molecular docking calculations.	Curcumin	27-35	casein beta	Bos taurus	100-111
24228095-9	2013	5-FU induced dramatic increase of serum endotoxin, D-lactate and D-Amino-Acid Oxidase (DAO) that were significantly reversed by Curcumin treatment.	Curcumin	128-136	D-amino-acid oxidase	Rattus norvegicus	87-90
24228095-12	2013	Interestingly, Bcl-2 expression was low in control group but increased after 5-FU treatment (p&gt;0.05) and Curcumin treatment further stimulated Bcl-2 expression (p&lt;0.05).	Curcumin	108-116	BCL2, apoptosis regulator	Rattus norvegicus	146-151
24228095-13	2013	CONCLUSIONS: Curcumin can significantly reverse chemotherapy-induced weight-loss, increase of serum endotoxin, D-lactate and DAO and damage to intestinal mucosa structure.	Curcumin	13-21	D-amino-acid oxidase	Rattus norvegicus	125-128
24228095-14	2013	Curcumin also reduced the expression of pro-apoptotic Bax but stimulated anti-apoptotic Bcl-2 to attenuate 5-FU-induced apoptosis of intestinal epithelial cells.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	88-93
24011306-0	2013	Curcumin abrogates LPS-induced pro-inflammatory cytokines in RAW 264.7 macrophages.	Curcumin	0-8	toll-like receptor 4	Mus musculus	19-22
23830979-3	2013	Curcumin, a known antagonist of TNFalpha in multiple cell types and tissues, was chemically modified and conjugated to a thermally responsive elastin-like polypeptide (ELP) to create an injectable depot for sustained, local delivery of curcumin to treat neuroinflammation.	Curcumin	0-8	tumor necrosis factor	Mus musculus	32-40
23830979-5	2013	ELP-curcumin conjugates were shown to display high drug loading, rapidly release curcumin in vitro via degradable carbamate bonds, and retain in vitro bioactivity against TNFalpha-induced cytotoxicity and monocyte activation with IC50 only two-fold higher than curcumin.	Curcumin	4-12	tumor necrosis factor	Mus musculus	171-179
23888334-3	2013	A2 also showed a stronger inhibitory effect than curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in NF-kappaB activation and IL-1beta expression as well as in aldose reductase activity.	Curcumin	49-57	interleukin 1 beta	Mus musculus	150-158
23888334-5	2013	In vivo studies indicated that A2 was more potent than curcumin for inhibiting TPA-induced ear edema and TPA-induced increases in IL-1beta.	Curcumin	55-63	interleukin 1 beta	Mus musculus	130-138
24011306-4	2013	The aim was to assess if these pathways are involved in curcumin-mediated effects on LPS-induced expression of these cytokines in macrophages.	Curcumin	56-64	toll-like receptor 4	Mus musculus	85-88
24011306-6	2013	Curcumin potently inhibited LPS-induced expression of IL-6, TNF-alpha and COX-2 mRNA and prevented LPS-induced inhibition of SOCS-1 and -3 expression and the inhibition of the activation of p38 MAPKinase by modulation of its nuclear translocation.	Curcumin	0-8	toll-like receptor 4	Mus musculus	28-31
24011306-6	2013	Curcumin potently inhibited LPS-induced expression of IL-6, TNF-alpha and COX-2 mRNA and prevented LPS-induced inhibition of SOCS-1 and -3 expression and the inhibition of the activation of p38 MAPKinase by modulation of its nuclear translocation.	Curcumin	0-8	interleukin 6	Mus musculus	54-58
24011306-6	2013	Curcumin potently inhibited LPS-induced expression of IL-6, TNF-alpha and COX-2 mRNA and prevented LPS-induced inhibition of SOCS-1 and -3 expression and the inhibition of the activation of p38 MAPKinase by modulation of its nuclear translocation.	Curcumin	0-8	tumor necrosis factor	Mus musculus	60-69
24011306-6	2013	Curcumin potently inhibited LPS-induced expression of IL-6, TNF-alpha and COX-2 mRNA and prevented LPS-induced inhibition of SOCS-1 and -3 expression and the inhibition of the activation of p38 MAPKinase by modulation of its nuclear translocation.	Curcumin	0-8	toll-like receptor 4	Mus musculus	99-102
24011306-7	2013	In conclusion, curcumin potently inhibits expression of LPS-induced inflammatory cytokines in macrophages via mechanisms that involve modulation of expression and activity of SOCS-1 and SOCS-3 and of p38 MAPK.	Curcumin	15-23	toll-like receptor 4	Mus musculus	56-59
23719767-4	2013	Recently, curcumin has been shown to have an antagonizing effect on transient receptor potential vanilloid type 1 (TRPV1) ion channels.	Curcumin	10-18	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	68-113
23719767-4	2013	Recently, curcumin has been shown to have an antagonizing effect on transient receptor potential vanilloid type 1 (TRPV1) ion channels.	Curcumin	10-18	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	115-120
23175174-10	2013	BAY 117085 and curcumin, which are two NF-kappaB inhibitors, led to a decrease in the ratio of ADAMTS9/beta-actin.	Curcumin	15-23	nuclear factor kappa B subunit 1	Homo sapiens	39-48
23173828-8	2013	The addition of PD98059, LY294002, NAC, curcumin, EGCG, and SB203580 markedly inhibited TGM-2 expression induced by CsA (P &lt;0.05).	Curcumin	40-48	transglutaminase 2	Homo sapiens	88-93
23917396-0	2013	Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	96-100
24114697-0	2013	In vivo study on the effects of curcumin on the expression profiles of anti-tumour genes (VEGF, CyclinD1 and CDK4) in liver of rats injected with DEN.	Curcumin	32-40	cyclin D1	Rattus norvegicus	96-104
24114697-0	2013	In vivo study on the effects of curcumin on the expression profiles of anti-tumour genes (VEGF, CyclinD1 and CDK4) in liver of rats injected with DEN.	Curcumin	32-40	cyclin-dependent kinase 4	Rattus norvegicus	109-113
24114697-2	2013	Results showed that blood levels of Gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase, glutathione S-transferase, and liver level of MD were significantly decreased after curcumin feeding.	Curcumin	201-209	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	63-89
24114697-4	2013	Moreover, RT-PCR and Western blot analysis results showed that curcumin treatment significantly decreased liver vascular endothelial growth factor (VEGF), CyclinD1 and CDK4 mRNA expression levels and CyclinD1 and CDK4 proteins levels in liver cancer rats.	Curcumin	63-71	cyclin D1	Rattus norvegicus	155-163
24114697-4	2013	Moreover, RT-PCR and Western blot analysis results showed that curcumin treatment significantly decreased liver vascular endothelial growth factor (VEGF), CyclinD1 and CDK4 mRNA expression levels and CyclinD1 and CDK4 proteins levels in liver cancer rats.	Curcumin	63-71	cyclin-dependent kinase 4	Rattus norvegicus	168-172
24114697-4	2013	Moreover, RT-PCR and Western blot analysis results showed that curcumin treatment significantly decreased liver vascular endothelial growth factor (VEGF), CyclinD1 and CDK4 mRNA expression levels and CyclinD1 and CDK4 proteins levels in liver cancer rats.	Curcumin	63-71	cyclin D1	Rattus norvegicus	200-208
24114697-4	2013	Moreover, RT-PCR and Western blot analysis results showed that curcumin treatment significantly decreased liver vascular endothelial growth factor (VEGF), CyclinD1 and CDK4 mRNA expression levels and CyclinD1 and CDK4 proteins levels in liver cancer rats.	Curcumin	63-71	cyclin-dependent kinase 4	Rattus norvegicus	213-217
23856612-0	2013	Curcumin ameliorates dextran sulfate sodium-induced experimental colitis by blocking STAT3 signaling pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	85-90
23856612-2	2013	The purpose of the study was to investigate whether curcumin could exert its therapeutic effects in experimental colitis by inhibiting STAT3 pathway.	Curcumin	52-60	signal transducer and activator of transcription 3	Mus musculus	135-140
23856612-10	2013	CONCLUSION: Curcumin exerts beneficial effects in experimental colitis by the suppression of STAT3 pathway, which may therefore provide a better understanding of the mechanism of action for curcumin in treating colitis.	Curcumin	12-20	signal transducer and activator of transcription 3	Mus musculus	93-98
23856612-10	2013	CONCLUSION: Curcumin exerts beneficial effects in experimental colitis by the suppression of STAT3 pathway, which may therefore provide a better understanding of the mechanism of action for curcumin in treating colitis.	Curcumin	190-198	signal transducer and activator of transcription 3	Mus musculus	93-98
23816368-9	2013	Curcumin, in the presence of Abeta, activated Akt which in turn phosphorylates GSK-3beta, and resulted in the inhibition of GSK-3beta.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	46-49
23173828-10	2013	In addition, TGM-2 induced by CsA is downregulated by PD98059, LY294002, NAC, curcumin, EGCG, and SB203580.	Curcumin	78-86	transglutaminase 2	Homo sapiens	13-18
23760980-3	2013	However, whether miR-200a/b plays a role in curcumin-mediated treatment of hepatocellular carcinoma (HCC) is unknown.	Curcumin	44-52	microRNA 200a	Homo sapiens	17-25
23760980-12	2013	The expression levels of miR-200a/b might determine the therapeutic efficacy of curcumin on HCC cells.	Curcumin	80-88	microRNA 200a	Homo sapiens	25-33
23616010-7	2013	Suppression of c-Jun/AP-1 activation using a natural inhibitor curcumin decreased the expression of caspase-3, MMP-9, and TF, as well as the proliferation and migration of SW620 cells induced by PAR2-AP or FVIIa.	Curcumin	63-71	caspase 3	Homo sapiens	100-109
23760980-8	2013	We found that HepG2 cells, which were more resistant to curcumin treatment than HepJ5 cells, expressed higher levels of miR-200a/b.	Curcumin	56-64	microRNA 200a	Homo sapiens	120-128
23760980-9	2013	The MTT assay revealed that the overexpression of miR-200a/b in HepJ5 cells conferred enhanced resistance to curcumin treatment compared with the control cells.	Curcumin	109-117	microRNA 200a	Homo sapiens	50-58
23760980-11	2013	Finally, we evaluated the levels of Bcl-2, Bax, and Bad, and found a decrease of Bcl-2 levels and increase of Bad levels in the J5-control cells treated with curcumin.	Curcumin	158-166	BCL2 apoptosis regulator	Homo sapiens	36-41
23760980-11	2013	Finally, we evaluated the levels of Bcl-2, Bax, and Bad, and found a decrease of Bcl-2 levels and increase of Bad levels in the J5-control cells treated with curcumin.	Curcumin	158-166	BCL2 associated X, apoptosis regulator	Homo sapiens	43-46
23760980-11	2013	Finally, we evaluated the levels of Bcl-2, Bax, and Bad, and found a decrease of Bcl-2 levels and increase of Bad levels in the J5-control cells treated with curcumin.	Curcumin	158-166	BCL2 apoptosis regulator	Homo sapiens	81-86
24422402-0	2013	[Effect of curcumin on expression of AKT and p-AKT in hippocampus CA1 area of App/PS1 double transgenic mice].	Curcumin	11-19	thymoma viral proto-oncogene 1	Mus musculus	37-40
24422402-0	2013	[Effect of curcumin on expression of AKT and p-AKT in hippocampus CA1 area of App/PS1 double transgenic mice].	Curcumin	11-19	thymoma viral proto-oncogene 1	Mus musculus	47-50
24422402-13	2013	CONCLUSION: Curcumin can recover the decreased AKT and p-AKT cells in hippocampus CAl area of APP/PS1 double transgenic mice of the AD model, suggesting that curcumin may regulate AKT and its phosphorylation process, as well as PI3K/AKT insulin signal transduction pathway, and show the anti-AD effect.	Curcumin	12-20	thymoma viral proto-oncogene 1	Mus musculus	57-60
24422402-13	2013	CONCLUSION: Curcumin can recover the decreased AKT and p-AKT cells in hippocampus CAl area of APP/PS1 double transgenic mice of the AD model, suggesting that curcumin may regulate AKT and its phosphorylation process, as well as PI3K/AKT insulin signal transduction pathway, and show the anti-AD effect.	Curcumin	12-20	thymoma viral proto-oncogene 1	Mus musculus	57-60
24422402-1	2013	OBJECTIVE: To observe the effect of curcumin on the expressions of AKT (serine-threonine kinase, AKT, also known as PKB) and p-AKT (phosphated serine-threonine kinase, p-AKT) in APP/PS1 double transgenic mice of the AD model.	Curcumin	36-44	thymoma viral proto-oncogene 1	Mus musculus	67-70
24422402-13	2013	CONCLUSION: Curcumin can recover the decreased AKT and p-AKT cells in hippocampus CAl area of APP/PS1 double transgenic mice of the AD model, suggesting that curcumin may regulate AKT and its phosphorylation process, as well as PI3K/AKT insulin signal transduction pathway, and show the anti-AD effect.	Curcumin	12-20	thymoma viral proto-oncogene 1	Mus musculus	57-60
24422402-13	2013	CONCLUSION: Curcumin can recover the decreased AKT and p-AKT cells in hippocampus CAl area of APP/PS1 double transgenic mice of the AD model, suggesting that curcumin may regulate AKT and its phosphorylation process, as well as PI3K/AKT insulin signal transduction pathway, and show the anti-AD effect.	Curcumin	158-166	thymoma viral proto-oncogene 1	Mus musculus	47-50
24422402-1	2013	OBJECTIVE: To observe the effect of curcumin on the expressions of AKT (serine-threonine kinase, AKT, also known as PKB) and p-AKT (phosphated serine-threonine kinase, p-AKT) in APP/PS1 double transgenic mice of the AD model.	Curcumin	36-44	thymoma viral proto-oncogene 1	Mus musculus	97-100
24422402-13	2013	CONCLUSION: Curcumin can recover the decreased AKT and p-AKT cells in hippocampus CAl area of APP/PS1 double transgenic mice of the AD model, suggesting that curcumin may regulate AKT and its phosphorylation process, as well as PI3K/AKT insulin signal transduction pathway, and show the anti-AD effect.	Curcumin	158-166	thymoma viral proto-oncogene 1	Mus musculus	57-60
24422402-13	2013	CONCLUSION: Curcumin can recover the decreased AKT and p-AKT cells in hippocampus CAl area of APP/PS1 double transgenic mice of the AD model, suggesting that curcumin may regulate AKT and its phosphorylation process, as well as PI3K/AKT insulin signal transduction pathway, and show the anti-AD effect.	Curcumin	158-166	thymoma viral proto-oncogene 1	Mus musculus	57-60
24422402-1	2013	OBJECTIVE: To observe the effect of curcumin on the expressions of AKT (serine-threonine kinase, AKT, also known as PKB) and p-AKT (phosphated serine-threonine kinase, p-AKT) in APP/PS1 double transgenic mice of the AD model.	Curcumin	36-44	thymoma viral proto-oncogene 1	Mus musculus	116-119
24422402-13	2013	CONCLUSION: Curcumin can recover the decreased AKT and p-AKT cells in hippocampus CAl area of APP/PS1 double transgenic mice of the AD model, suggesting that curcumin may regulate AKT and its phosphorylation process, as well as PI3K/AKT insulin signal transduction pathway, and show the anti-AD effect.	Curcumin	158-166	thymoma viral proto-oncogene 1	Mus musculus	57-60
24422402-1	2013	OBJECTIVE: To observe the effect of curcumin on the expressions of AKT (serine-threonine kinase, AKT, also known as PKB) and p-AKT (phosphated serine-threonine kinase, p-AKT) in APP/PS1 double transgenic mice of the AD model.	Curcumin	36-44	thymoma viral proto-oncogene 1	Mus musculus	97-100
24422402-1	2013	OBJECTIVE: To observe the effect of curcumin on the expressions of AKT (serine-threonine kinase, AKT, also known as PKB) and p-AKT (phosphated serine-threonine kinase, p-AKT) in APP/PS1 double transgenic mice of the AD model.	Curcumin	36-44	thymoma viral proto-oncogene 1	Mus musculus	97-100
24422402-11	2013	Compared with the model group, AKT and p-AKT positive cells of hippocampus CA1 area increased obviously in the rosiglitazone group and high and medium dose curcumin group (P &lt;0.05 or P &lt;0.01) ,especially the medium dose group (P &lt;0.01).	Curcumin	156-164	thymoma viral proto-oncogene 1	Mus musculus	31-34
24422402-11	2013	Compared with the model group, AKT and p-AKT positive cells of hippocampus CA1 area increased obviously in the rosiglitazone group and high and medium dose curcumin group (P &lt;0.05 or P &lt;0.01) ,especially the medium dose group (P &lt;0.01).	Curcumin	156-164	thymoma viral proto-oncogene 1	Mus musculus	41-44
24422402-13	2013	CONCLUSION: Curcumin can recover the decreased AKT and p-AKT cells in hippocampus CAl area of APP/PS1 double transgenic mice of the AD model, suggesting that curcumin may regulate AKT and its phosphorylation process, as well as PI3K/AKT insulin signal transduction pathway, and show the anti-AD effect.	Curcumin	12-20	thymoma viral proto-oncogene 1	Mus musculus	47-50
24058438-9	2013	Treatment with salubrinal, MG132 and COX2 inhibitor, like curcumin, prevented the replication of RSV and the epithelial responses, and treatment with salubrinal and MG132 enhanced the upregulation of tight junction molecules induced by infection with RSV.	Curcumin	58-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-41
24191240-9	2013	Taking together, these studies attribute the protective effect of curcumin in the kidney to the induction of the master regulator of antioxidant response nuclear factor erythroid-derived 2 (Nrf2), inhibition of mitochondrial dysfunction, attenuation of inflammatory response, preservation of antioxidant enzymes and prevention of oxidative stress.	Curcumin	66-74	NFE2 like bZIP transcription factor 2	Homo sapiens	154-188
24058438-7	2013	Curcumin also has wide pharmacokinetic effects as an inhibitor of NF-kappaB, eIF-2alpha dephosphorylation, proteasome and COX2.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	66-75
24058438-7	2013	Curcumin also has wide pharmacokinetic effects as an inhibitor of NF-kappaB, eIF-2alpha dephosphorylation, proteasome and COX2.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-126
24004419-7	2013	Moreover, curcumin reduces Abeta-induced dye leakage from lipid-bilayer-covered, dye-loaded, porous silica microspheres.	Curcumin	10-18	amyloid beta precursor protein	Homo sapiens	27-32
24004419-8	2013	Because curcumin neither affects the inherent surface activity of Abeta nor modifies the membrane properties, it reduces Abeta insertion by directly attenuating Abeta-membrane interactions and reducing Abeta-induced membrane disruption.	Curcumin	8-16	amyloid beta precursor protein	Homo sapiens	121-126
24004419-8	2013	Because curcumin neither affects the inherent surface activity of Abeta nor modifies the membrane properties, it reduces Abeta insertion by directly attenuating Abeta-membrane interactions and reducing Abeta-induced membrane disruption.	Curcumin	8-16	amyloid beta precursor protein	Homo sapiens	121-126
24004419-8	2013	Because curcumin neither affects the inherent surface activity of Abeta nor modifies the membrane properties, it reduces Abeta insertion by directly attenuating Abeta-membrane interactions and reducing Abeta-induced membrane disruption.	Curcumin	8-16	amyloid beta precursor protein	Homo sapiens	121-126
24004419-9	2013	Although the exact molecular mechanism of curcumin"s membrane protective effect remains unclear, this effect could in part contribute to curcumin"s neuroprotective effect with respect to Abeta-induced toxicity.	Curcumin	137-145	amyloid beta precursor protein	Homo sapiens	187-192
24004419-10	2013	Our work reveals a novel molecular mechanism by which curcumin reduces Abeta-related pathology and toxicity and suggests a therapeutic strategy for preventing or treating AD by targeting the inhibition of Abeta-induced membrane disruption.	Curcumin	54-62	amyloid beta precursor protein	Homo sapiens	71-76
24004419-10	2013	Our work reveals a novel molecular mechanism by which curcumin reduces Abeta-related pathology and toxicity and suggests a therapeutic strategy for preventing or treating AD by targeting the inhibition of Abeta-induced membrane disruption.	Curcumin	54-62	amyloid beta precursor protein	Homo sapiens	205-210
24004419-2	2013	Curcumin, a small dietary polyphenolic molecule, has been shown to reduce Abeta-induced toxicity and AD pathology.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	74-79
24004419-3	2013	We investigate here the effect of curcumin on Abeta40-induced toxicity in cultured human neuroblastoma SH-SY5Y cells and test a novel neuroprotection mechanism in which curcumin reduces Abeta-membrane interactions and attenuates Abeta-induced membrane disruptions.	Curcumin	34-42	amyloid beta precursor protein	Homo sapiens	46-51
24004419-3	2013	We investigate here the effect of curcumin on Abeta40-induced toxicity in cultured human neuroblastoma SH-SY5Y cells and test a novel neuroprotection mechanism in which curcumin reduces Abeta-membrane interactions and attenuates Abeta-induced membrane disruptions.	Curcumin	169-177	amyloid beta precursor protein	Homo sapiens	186-191
24004419-6	2013	Curcumin dose-dependently ameliorates Abeta-induced neurotoxicity and reduces either the rate or extent of Abeta insertion into anionic lipid monolayers.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	38-43
24004419-6	2013	Curcumin dose-dependently ameliorates Abeta-induced neurotoxicity and reduces either the rate or extent of Abeta insertion into anionic lipid monolayers.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	107-112
24191240-9	2013	Taking together, these studies attribute the protective effect of curcumin in the kidney to the induction of the master regulator of antioxidant response nuclear factor erythroid-derived 2 (Nrf2), inhibition of mitochondrial dysfunction, attenuation of inflammatory response, preservation of antioxidant enzymes and prevention of oxidative stress.	Curcumin	66-74	NFE2 like bZIP transcription factor 2	Homo sapiens	190-194
23685957-8	2013	Curcumin dose-dependently induced apoptosis of NTera-2 cells by reducing FasL expression and Bcl-2-to-Bax ratio, and activating caspase-9, -8 and -3.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	93-98
24034496-14	2013	CONCLUSIONS: The SK-BR-3 cells and DMBA-induced tumors, both with an ER- and Her-2+ phenotype, were affected by the synergistic interaction of DHA and CCM.	Curcumin	151-154	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-82
23845850-4	2013	The results suggest that curcumin treatment markedly attenuated CCl4-induced liver fibrosis, as assessed by histology and hydroxyproline content, and inhibited hepatic stellate cell activation.	Curcumin	25-33	C-C motif chemokine ligand 4	Rattus norvegicus	64-68
23845850-5	2013	Curcumin ameliorated hepatic angiogenesis, as assessed by measuring microvessel density using Von Willebrand factor staining and by examining the expression of the endothelial cell markers CD31 and vascular endothelial growth factor receptor (VEGFR)-2 in the livers.	Curcumin	0-8	platelet and endothelial cell adhesion molecule 1	Rattus norvegicus	189-193
23845850-8	2013	In conclusion, curcumin ameliorates hepatic angiogenesis and sinusoidal capillarization in CCl4-induced rat liver fibrosis through suppressing multiple proangiogenic factors.	Curcumin	15-23	C-C motif chemokine ligand 4	Rattus norvegicus	91-95
23685957-8	2013	Curcumin dose-dependently induced apoptosis of NTera-2 cells by reducing FasL expression and Bcl-2-to-Bax ratio, and activating caspase-9, -8 and -3.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	102-105
23685957-10	2013	Curcumin inhibited ErbB2 expression, and decreased the phosphorylation of Akt and ERK in NTera-2 cells.	Curcumin	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	19-24
23685957-10	2013	Curcumin inhibited ErbB2 expression, and decreased the phosphorylation of Akt and ERK in NTera-2 cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	74-77
23685957-10	2013	Curcumin inhibited ErbB2 expression, and decreased the phosphorylation of Akt and ERK in NTera-2 cells.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	82-85
24023285-6	2013	RESULTS: The in vitro (IC50) liposomal curcumin proliferation-inhibiting concentration was 17.5 muM.	Curcumin	39-47	latexin	Homo sapiens	96-99
23272912-0	2013	Hitting the golden TORget: curcumin"s effects on mTOR signaling.	Curcumin	27-35	mechanistic target of rapamycin kinase	Homo sapiens	49-53
23272912-6	2013	Recent studies have identified mTOR as a novel target of curcumin.	Curcumin	57-65	mechanistic target of rapamycin kinase	Homo sapiens	31-35
23272912-7	2013	Here we focus on reviewing current knowledge regarding the effects of curcumin on mTOR signaling for better understanding the anticancer mechanism of curcumin.	Curcumin	70-78	mechanistic target of rapamycin kinase	Homo sapiens	82-86
23272912-7	2013	Here we focus on reviewing current knowledge regarding the effects of curcumin on mTOR signaling for better understanding the anticancer mechanism of curcumin.	Curcumin	150-158	mechanistic target of rapamycin kinase	Homo sapiens	82-86
23764358-5	2013	The co-treatment of Cd with curcumin significantly reduced the levels of TNF-alpha and IL-6 and ameliorated the alteration in oxidative status biomarkers induced by Cd.	Curcumin	28-36	tumor necrosis factor	Rattus norvegicus	73-82
23272912-8	2013	The emerging studies of mTOR signaling and clinical studies on curcumin with cancer patients are also discussed here.	Curcumin	63-71	mechanistic target of rapamycin kinase	Homo sapiens	24-28
23880083-0	2013	Exploring pyrimidine-substituted curcumin analogues: design, synthesis and effects on EGFR signaling.	Curcumin	33-41	epidermal growth factor receptor	Homo sapiens	86-90
23880083-2	2013	Curcumin inhibits cancer cell growth in vitro by suppressing gene expression of EGFR and reduces tumor growth in various animal models.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	80-84
23574662-8	2013	Moreover, curcumin activated AMP-activated protein kinase (AMPK) and elevated the gene expression of peroxisome proliferator-activated receptor alpha.	Curcumin	10-18	peroxisome proliferator activated receptor alpha	Mus musculus	101-149
23574662-9	2013	By contrast, curcumin suppressed the HFD-mediated increases in sterol regulatory element-binding protein-1, acetyl-CoA carboxylase 1, fatty acid synthase and cluster of differentiation 36 expression.	Curcumin	13-21	fatty acid synthase	Mus musculus	134-153
23764358-5	2013	The co-treatment of Cd with curcumin significantly reduced the levels of TNF-alpha and IL-6 and ameliorated the alteration in oxidative status biomarkers induced by Cd.	Curcumin	28-36	interleukin 6	Rattus norvegicus	87-91
23807697-8	2013	The data presented in this study demonstrate that the proliferation of ASMCs is inhibited by curcumin in vitro and in vivo; curcumin exerts these effects by upregulating the expression of caveolin-1 and blocking the activation of the ERK pathway.	Curcumin	124-132	Eph receptor B1	Rattus norvegicus	234-237
23871787-7	2013	Furthermore, both the hepatic Nrf2 protein and two typically recognized Nrf2 downstream genes, NADP(H) quinine oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1), were consistently up-regulated in curcumin-treated mice.	Curcumin	198-206	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
23871787-7	2013	Furthermore, both the hepatic Nrf2 protein and two typically recognized Nrf2 downstream genes, NADP(H) quinine oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1), were consistently up-regulated in curcumin-treated mice.	Curcumin	198-206	nuclear factor, erythroid derived 2, like 2	Mus musculus	72-76
23871787-8	2013	Our study confirmed the antagonistic roles of curcumin to counteract inorganic arsenic-induced hepatic toxicity in vivo, and suggested that the potent Nrf2 activation capability might be valuable for the protective effects of curcumin against arsenic intoxication.	Curcumin	226-234	nuclear factor, erythroid derived 2, like 2	Mus musculus	151-155
23871787-0	2013	Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	117-121
23871787-3	2013	What"s more, curcumin is recently proved to exert its chemopreventive effects partly through the activation of nuclear factor (erythroid-2 related) factor 2 (Nrf2) and its antioxidant and phase II detoxifying enzymes.	Curcumin	13-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	158-162
23807697-4	2013	The thickness of the airway wall, the airway smooth muscle layer, the number of ASMCs and the expression of extracellular signal-regulated kinase (ERK) were significantly reduced in the curcumin-treated group as compared with the model group.	Curcumin	186-194	Eph receptor B1	Rattus norvegicus	108-145
23807697-4	2013	The thickness of the airway wall, the airway smooth muscle layer, the number of ASMCs and the expression of extracellular signal-regulated kinase (ERK) were significantly reduced in the curcumin-treated group as compared with the model group.	Curcumin	186-194	Eph receptor B1	Rattus norvegicus	147-150
23174956-0	2013	Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	101-105
23807697-7	2013	Curcumin upregulated the mRNA and protein expression of caveolin-1.	Curcumin	0-8	caveolin 1	Rattus norvegicus	56-66
23807697-8	2013	The data presented in this study demonstrate that the proliferation of ASMCs is inhibited by curcumin in vitro and in vivo; curcumin exerts these effects by upregulating the expression of caveolin-1 and blocking the activation of the ERK pathway.	Curcumin	124-132	caveolin 1	Rattus norvegicus	188-198
23174956-1	2013	SCOPE: We hypothesized that curcumin, by increasing the expression of nuclear factor-erythroid-2-related factor 2 (Nrf2), could reduce oxidative stress, inflammation, and renal fibrosis in remnant kidney.	Curcumin	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	70-113
23174956-1	2013	SCOPE: We hypothesized that curcumin, by increasing the expression of nuclear factor-erythroid-2-related factor 2 (Nrf2), could reduce oxidative stress, inflammation, and renal fibrosis in remnant kidney.	Curcumin	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	115-119
23174956-8	2013	CONCLUSION: These findings demonstrate that, by modulating Nrf2-Keap1 pathway, the curcumin effectively attenuates oxidative stress, inflammation, and renal fibrosis, which suggest that curcumin hold promising potential for safe treatment of chronic kidney disease.	Curcumin	83-91	NFE2 like bZIP transcription factor 2	Rattus norvegicus	59-63
23174956-8	2013	CONCLUSION: These findings demonstrate that, by modulating Nrf2-Keap1 pathway, the curcumin effectively attenuates oxidative stress, inflammation, and renal fibrosis, which suggest that curcumin hold promising potential for safe treatment of chronic kidney disease.	Curcumin	186-194	NFE2 like bZIP transcription factor 2	Rattus norvegicus	59-63
23812632-8	2013	Curcumin effectively blocked hyperoxia-induced lung injury based on systematic analysis of markers for lung injury (apoptosis, Bcl-2/Bax, collagen III, fibronectin, vimentin, calponin, and elastin-related genes) and lung morphology (radial alveolar count and alveolar septal thickness).	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	127-132
23754571-6	2013	Finally curcumin modulates miRNAs (miR-15a, miR-16, miR-21, miR-22, miR-26, miR-101, miR-146, miR-200, miR-203, and let-7) and their multiple target genes.	Curcumin	8-16	glycerophosphodiester phosphodiesterase 1	Homo sapiens	44-50
23754571-6	2013	Finally curcumin modulates miRNAs (miR-15a, miR-16, miR-21, miR-22, miR-26, miR-101, miR-146, miR-200, miR-203, and let-7) and their multiple target genes.	Curcumin	8-16	microRNA 22	Homo sapiens	60-66
23900994-6	2013	In this review we summarise the ability of curcumin to interfere with signalling pathways Wnt, Hedgehog, Notch, Signal Transducers and Activator (STAT) and interleukin-8, and report curcumin-induced changes in function and properties of cancer stem cells.	Curcumin	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	156-169
23901044-0	2013	Curcumin protects neuronal-like cells against acrolein by restoring Akt and redox signaling pathways.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	68-71
23132777-8	2013	Paralleling hKv1.3 inhibition, curcumin significantly inhibited proliferation and interferon-gamma secretion of T(EM) cells.	Curcumin	31-39	interferon gamma	Homo sapiens	82-98
23967300-2	2013	Further, we reported that curcumin targets IR-induced survival signaling and NFkappaB dependent hTERT mediated clonal expansion in human NB cells.	Curcumin	26-34	nuclear factor kappa B subunit 1	Homo sapiens	77-85
23940701-0	2013	The curcumin analog EF24 targets NF-kappaB and miRNA-21, and has potent anticancer activity in vitro and in vivo.	Curcumin	4-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	33-42
23977989-0	2013	Curcumin ameliorates TNF-alpha-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	21-30
23624207-5	2013	This is the first report to show that curcumin (10-50 muM) causes a significant, dose-dependent, 2-3 fold increase in uptake of radiolabelled folic acid and methotrexate into KG-1 cells both at 24 h and 48 h of treatment.	Curcumin	38-46	latexin	Homo sapiens	54-57
23624207-6	2013	Interestingly, pre-treatment of KG-1 leukemic cells with curcumin (10 muM and 25 muM) also caused a statistically significant enhancement in the cytotoxicity of methotrexate.	Curcumin	57-65	latexin	Homo sapiens	70-73
23624207-6	2013	Interestingly, pre-treatment of KG-1 leukemic cells with curcumin (10 muM and 25 muM) also caused a statistically significant enhancement in the cytotoxicity of methotrexate.	Curcumin	57-65	latexin	Homo sapiens	81-84
23425071-0	2013	Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	44-47
23425071-4	2013	In the current report, we describe an alternative, curcumin (diferuloylmethane), a component of turmeric (Curcuma longa) that is very inexpensive, orally bioavailable and highly safe in humans, yet can block TNF-alpha action and production in in vitro models, in animal models and in humans.	Curcumin	51-59	tumor necrosis factor	Homo sapiens	208-217
23425071-4	2013	In the current report, we describe an alternative, curcumin (diferuloylmethane), a component of turmeric (Curcuma longa) that is very inexpensive, orally bioavailable and highly safe in humans, yet can block TNF-alpha action and production in in vitro models, in animal models and in humans.	Curcumin	61-78	tumor necrosis factor	Homo sapiens	208-217
23425071-5	2013	In addition, we provide evidence for curcumin"s activities against all of the diseases for which TNF blockers are currently being used.	Curcumin	37-45	tumor necrosis factor	Homo sapiens	97-100
22653297-8	2013	Lifespan extension of curcumin in Drosophila was associated with the up-regulation of Mn-SOD and CuZn-SOD genes, and the down-regulation of dInR, ATTD, Def, CecB, and DptB genes.	Curcumin	22-30	Defensin	Drosophila melanogaster	152-155
22653297-8	2013	Lifespan extension of curcumin in Drosophila was associated with the up-regulation of Mn-SOD and CuZn-SOD genes, and the down-regulation of dInR, ATTD, Def, CecB, and DptB genes.	Curcumin	22-30	Diptericin B	Drosophila melanogaster	167-171
23977989-0	2013	Curcumin ameliorates TNF-alpha-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells.	Curcumin	0-8	GLI family zinc finger 2	Homo sapiens	72-77
23977989-4	2013	In addition, curcumin induced Nrf2 activation in dose- and time-dependent manners in the HaCaT cells.	Curcumin	13-21	NFE2 like bZIP transcription factor 2	Homo sapiens	30-34
23977989-5	2013	Curcumin suppressed TNF-alpha- induced ICAM-1 expression and subsequent monocyte adhesion, which were reversed by the addition of tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, or HO-1 knockdown using siRNA.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	20-29
23977989-6	2013	Furthermore, Nrf2 knockdown using siRNA reversed the inhibitory effect of curcumin on the TNF-alpha-induced ICAM-1 expression and adhesion of monocytes to keratinocytes.	Curcumin	74-82	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
23977989-6	2013	Furthermore, Nrf2 knockdown using siRNA reversed the inhibitory effect of curcumin on the TNF-alpha-induced ICAM-1 expression and adhesion of monocytes to keratinocytes.	Curcumin	74-82	tumor necrosis factor	Homo sapiens	90-99
23977989-7	2013	These results suggest that curcumin may exert its anti-inflammatory activity by suppressing the TNF-alpha-induced ICAM-1 expression and subsequent monocyte adhesion via expression of HO-1 in the keratinocytes.	Curcumin	27-35	tumor necrosis factor	Homo sapiens	96-105
23946685-5	2013	Radiation-induced transforming growth factor-beta1 (TGF-beta1), connective tissue growth factor (CTGF) expression, and collagen accumulation were also inhibited by curcumin.	Curcumin	164-172	transforming growth factor, beta 1	Rattus norvegicus	18-50
23959397-0	2013	Immunoliposome encapsulation increases cytotoxic activity and selectivity of curcumin and resveratrol against HER2 overexpressing human breast cancer cells.	Curcumin	77-85	erb-b2 receptor tyrosine kinase 2	Homo sapiens	110-114
23959397-5	2013	The results demonstrate that when HER2-targeted immunoliposomes are coupled to trastuzumab there is a dramatic increase in the antiproliferative effects of curcumin and resveratrol in HER2 positive human breast cancer cells in comparison to regular liposomed or free forms, indicating an increase of its therapeutic effect.	Curcumin	156-164	erb-b2 receptor tyrosine kinase 2	Homo sapiens	34-38
23959397-5	2013	The results demonstrate that when HER2-targeted immunoliposomes are coupled to trastuzumab there is a dramatic increase in the antiproliferative effects of curcumin and resveratrol in HER2 positive human breast cancer cells in comparison to regular liposomed or free forms, indicating an increase of its therapeutic effect.	Curcumin	156-164	erb-b2 receptor tyrosine kinase 2	Homo sapiens	184-188
23946685-5	2013	Radiation-induced transforming growth factor-beta1 (TGF-beta1), connective tissue growth factor (CTGF) expression, and collagen accumulation were also inhibited by curcumin.	Curcumin	164-172	transforming growth factor, beta 1	Rattus norvegicus	52-61
23946685-6	2013	Moreover, western blot analysis revealed that curcumin lowered radiation-induced increases of tumor necrosis factor-alpha (TNF-alpha), TNF receptor 1 (TNFR1), and cyclooxygenase-2 (COX-2).	Curcumin	46-54	tumor necrosis factor	Rattus norvegicus	94-121
23946685-6	2013	Moreover, western blot analysis revealed that curcumin lowered radiation-induced increases of tumor necrosis factor-alpha (TNF-alpha), TNF receptor 1 (TNFR1), and cyclooxygenase-2 (COX-2).	Curcumin	46-54	tumor necrosis factor	Rattus norvegicus	123-132
23946685-7	2013	Curcumin also inhibited the nuclear translocation of nuclear factor-kappa B (NF-kappaB) p65 in radiation-treated lungs.	Curcumin	0-8	synaptotagmin 1	Rattus norvegicus	88-91
23946688-0	2013	Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells.	Curcumin	48-56	tumor protein p53	Homo sapiens	7-10
23946688-0	2013	Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells.	Curcumin	48-56	notch receptor 1	Homo sapiens	11-17
23946688-3	2013	The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis.	Curcumin	192-200	tumor protein p53	Homo sapiens	56-59
23946688-3	2013	The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis.	Curcumin	192-200	tumor protein p53	Homo sapiens	173-176
23946688-3	2013	The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis.	Curcumin	192-200	notch receptor 1	Homo sapiens	177-183
23946688-4	2013	We found that curcumin treatment resulted in an induction of apoptosis in MDA-MB-231 cells, together with downregulation of Notch1 and its downstream target, Hes1.	Curcumin	14-22	notch receptor 1	Homo sapiens	124-130
23946688-6	2013	We confirmed the suppressive effect of curcumin on Notch1 transcription by performing a Notch1 promoter-driven reporter assay and identified a putative p53-binding site in the Notch1 promoter by EMSA and chromatin immunoprecipitation analysis.	Curcumin	39-47	notch receptor 1	Homo sapiens	51-57
23946688-6	2013	We confirmed the suppressive effect of curcumin on Notch1 transcription by performing a Notch1 promoter-driven reporter assay and identified a putative p53-binding site in the Notch1 promoter by EMSA and chromatin immunoprecipitation analysis.	Curcumin	39-47	notch receptor 1	Homo sapiens	88-94
23946688-6	2013	We confirmed the suppressive effect of curcumin on Notch1 transcription by performing a Notch1 promoter-driven reporter assay and identified a putative p53-binding site in the Notch1 promoter by EMSA and chromatin immunoprecipitation analysis.	Curcumin	39-47	tumor protein p53	Homo sapiens	152-155
23946688-6	2013	We confirmed the suppressive effect of curcumin on Notch1 transcription by performing a Notch1 promoter-driven reporter assay and identified a putative p53-binding site in the Notch1 promoter by EMSA and chromatin immunoprecipitation analysis.	Curcumin	39-47	notch receptor 1	Homo sapiens	88-94
23946688-8	2013	Moreover, curcumin-induced apoptosis was further enhanced by the knockdown of Notch1 or mutant p53, but it was decreased by the overexpression of active Notch1.	Curcumin	10-18	notch receptor 1	Homo sapiens	78-84
23946688-8	2013	Moreover, curcumin-induced apoptosis was further enhanced by the knockdown of Notch1 or mutant p53, but it was decreased by the overexpression of active Notch1.	Curcumin	10-18	tumor protein p53	Homo sapiens	95-98
23946688-8	2013	Moreover, curcumin-induced apoptosis was further enhanced by the knockdown of Notch1 or mutant p53, but it was decreased by the overexpression of active Notch1.	Curcumin	10-18	notch receptor 1	Homo sapiens	153-159
23946688-9	2013	Taken together, our results demonstrate, for the first time, that Notch1 is a transcriptional target of mutant p53 in breast cancer cells and suggest that the targeting of mutant p53 and/or Notch1 may be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to curcumin.	Curcumin	296-304	notch receptor 1	Homo sapiens	66-72
23946688-9	2013	Taken together, our results demonstrate, for the first time, that Notch1 is a transcriptional target of mutant p53 in breast cancer cells and suggest that the targeting of mutant p53 and/or Notch1 may be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to curcumin.	Curcumin	296-304	tumor protein p53	Homo sapiens	111-114
23946688-9	2013	Taken together, our results demonstrate, for the first time, that Notch1 is a transcriptional target of mutant p53 in breast cancer cells and suggest that the targeting of mutant p53 and/or Notch1 may be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to curcumin.	Curcumin	296-304	tumor protein p53	Homo sapiens	179-182
24325063-7	2013	Intervention by curcumin significantly inhibited the proliferation and migration of hypoxic HepG2 cells, and expressions of HIF-1alpha and vimentin decreased, and the expression of E-cadherin was up-regulated, showing statistical difference when compared with those of the CoCl2 group (P &lt; 0.05).	Curcumin	16-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	124-134
23440458-0	2013	Class 3 inhibition of hERG K+ channel by caffeic acid phenethyl ester (CAPE) and curcumin.	Curcumin	81-89	ETS transcription factor ERG	Homo sapiens	22-26
23440458-9	2013	Curcumin induced changes of I hERG similar to those of CAPE, while additional interaction with pore-blocking sites was suggested from attenuated I hERG,tail inhibition in Y652A and F656A.	Curcumin	0-8	ETS transcription factor ERG	Homo sapiens	30-34
23440458-10	2013	Interestingly, I hERG induced by human action potential voltage clamp was increased by CAPE while decreased by curcumin.	Curcumin	111-119	ETS transcription factor ERG	Homo sapiens	17-21
23998581-3	2013	ATRA could promote phosphorylation of AKT in NB4 cells at short time, but not had effect on phosphorylation of AKT in NB4-R1 cells; the curcumin could enhance the phosphorylation of AKT in NB4-1R cells, the curcumin combined with ATRA could further enhance the phosphorylation of AKT.	Curcumin	136-144	AKT serine/threonine kinase 1	Homo sapiens	38-41
23998581-4	2013	It is concluded that PI3K/AKT pathway inactivation may be one of the factors of drug resistance in APL and curcumin promotes differentiation of NB4-R1 through activating PI3K/AKT pathway.	Curcumin	107-115	AKT serine/threonine kinase 1	Homo sapiens	175-178
24325063-7	2013	Intervention by curcumin significantly inhibited the proliferation and migration of hypoxic HepG2 cells, and expressions of HIF-1alpha and vimentin decreased, and the expression of E-cadherin was up-regulated, showing statistical difference when compared with those of the CoCl2 group (P &lt; 0.05).	Curcumin	16-24	cadherin 1	Homo sapiens	181-191
24325063-9	2013	CONCLUSION: Curcumin could reverse the proliferation and migration of HepG2 cells under CoCl2-induced hypoxia condition, which might be associated with inhibiting up-regulated expressions of HIF-1alpha protein and EMT.	Curcumin	12-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	191-201
23819626-0	2013	Binding of curcumin with bovine serum albumin in the presence of iota-carrageenan and implications on the stability and antioxidant activity of curcumin.	Curcumin	11-19	albumin	Homo sapiens	32-45
23819626-0	2013	Binding of curcumin with bovine serum albumin in the presence of iota-carrageenan and implications on the stability and antioxidant activity of curcumin.	Curcumin	144-152	albumin	Homo sapiens	32-45
23666203-7	2013	High dosages (20, 50 muM) of curcumin induced a significant increase of apoptosis in Ben-Men-1 and primary meningioma cell cultures as demonstrated by morphological changes of cell nuclei, DNA fragmentation, translocation of cell membrane associated phosphatidyl serine and the induction of apoptotic-acting cleaved caspase-3.	Curcumin	29-37	menin 1	Homo sapiens	89-94
23894315-7	2013	Difluorinated curcumin (CDF), a novel analog of the dietary ingredient curcumin, which has been shown to inhibit the growth of 5-Flurouracil + Oxaliplatin resistant colon cancer cells, downregulated miR-21 in chemo-resistant colon cancer HCT116 and HT-29 cells and restored PTEN levels with subsequent reduction in Akt phosphorylation.	Curcumin	14-22	AKT serine/threonine kinase 1	Homo sapiens	315-318
23874481-11	2013	Treatment with NAC, curcumin, and EGCG markedly inhibited arecoline induced Snail expression (p&lt;0.05).	Curcumin	20-28	snail family transcriptional repressor 1	Homo sapiens	76-81
23874481-14	2013	In addition, arecoline induced Snail expression was downregulated by NAC, curcumin, and EGCG.	Curcumin	74-82	snail family transcriptional repressor 1	Homo sapiens	31-36
24555068-0	2013	Curcumin reduces prostaglandin E2, matrix metalloproteinase-3 and proteoglycan release in the secretome of interleukin 1beta-treated articular cartilage.	Curcumin	0-8	interleukin-1 beta	Equus caballus	107-124
24555068-2	2013	The aim of this study was to determine whether non-toxic concentrations of curcumin can reduce interleukin-1beta (IL-1beta)-stimulated inflammation and catabolism in an explant model of cartilage inflammation.	Curcumin	75-83	interleukin-1 beta	Equus caballus	95-112
23603982-0	2013	Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-kappaB signaling pathway with distinct mechanisms.	Curcumin	28-36	nuclear factor kappa B subunit 1	Homo sapiens	74-83
23603982-1	2013	AIM: Curcumin has shown promising anticancer activity, which relies on its inhibition on NF-kappaB pathway.	Curcumin	5-13	nuclear factor kappa B subunit 1	Homo sapiens	89-98
23603982-10	2013	RESULTS: P1, a tropinone curcumin, was found in HTS targeting the NF-kappaB pathway.	Curcumin	25-33	nuclear factor kappa B subunit 1	Homo sapiens	66-75
23603982-11	2013	Its IC50 value in inhibition of TNF-alpha-induced NF-kappaB activation was 0.8 mumol/L, whereas its IC50 values in inhibiting the growth of A549 and HeLa cells were 1.24 and 0.69 mumol/L, respectively, which was 20- to 30-fold more potent than curcumin.	Curcumin	244-252	tumor necrosis factor	Homo sapiens	32-41
23603982-17	2013	CONCLUSION: P1 is a novel curcumin analog with potent anticancer activities, which exerts a distinct inhibition on the NF-kappaB pathway.	Curcumin	26-34	nuclear factor kappa B subunit 1	Homo sapiens	119-128
23474829-0	2013	Curcumin inhibits the metastasis of K1 papillary thyroid cancer cells via modulating E-cadherin and matrix metalloproteinase-9 expression.	Curcumin	0-8	cadherin 1	Homo sapiens	85-95
23474829-2	2013	Curcumin at 12.5, 25 and 50 muM promoted mesenchymal-epithelial transition and decreased the migration rate of K1 cells by 24-87%.	Curcumin	0-8	latexin	Homo sapiens	28-31
23609161-0	2013	Curcumin inhibits TGFbeta1-induced CCN2 via Src, JNK, and Smad3 in gingiva.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	18-26
23609161-0	2013	Curcumin inhibits TGFbeta1-induced CCN2 via Src, JNK, and Smad3 in gingiva.	Curcumin	0-8	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	44-47
23609161-0	2013	Curcumin inhibits TGFbeta1-induced CCN2 via Src, JNK, and Smad3 in gingiva.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	49-52
23609161-8	2013	We further found that curcumin significantly abrogated the TGFbeta1-induced CCN2 in HGFs by inhibiting the phosphorylations of Src, JNK, and Smad3.	Curcumin	22-30	transforming growth factor beta 1	Homo sapiens	59-67
23609161-8	2013	We further found that curcumin significantly abrogated the TGFbeta1-induced CCN2 in HGFs by inhibiting the phosphorylations of Src, JNK, and Smad3.	Curcumin	22-30	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	127-130
23609161-8	2013	We further found that curcumin significantly abrogated the TGFbeta1-induced CCN2 in HGFs by inhibiting the phosphorylations of Src, JNK, and Smad3.	Curcumin	22-30	mitogen-activated protein kinase 8	Homo sapiens	132-135
23609161-9	2013	Furthermore, curcumin inhibited TGFbeta1-induced HGF migration and alpha-SMA expression.	Curcumin	13-21	transforming growth factor beta 1	Homo sapiens	32-40
23874455-4	2013	Pharmacologic targeting of STAT3 expression in cervical cancer cell lines either by STAT3-specific siRNA or blocking its tyrosine phosphorylation by AG490 or curcumin led to dose-dependent accumulation of p53 and pRb in cervical cancer cells.	Curcumin	158-166	signal transducer and activator of transcription 3	Homo sapiens	27-32
23874455-4	2013	Pharmacologic targeting of STAT3 expression in cervical cancer cell lines either by STAT3-specific siRNA or blocking its tyrosine phosphorylation by AG490 or curcumin led to dose-dependent accumulation of p53 and pRb in cervical cancer cells.	Curcumin	158-166	tumor protein p53	Homo sapiens	205-208
23645013-0	2013	Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-kappaB pathways.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	105-109
23430957-5	2013	As a novel histone deacetylases (HDACs) inhibitor, curcumin inhibited HDAC enzyme activities and decreased the levels of HDAC1, 3 and 8 but not HDAC2.	Curcumin	51-59	histone deacetylase 1	Homo sapiens	121-126
23825622-0	2013	Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice.	Curcumin	0-8	interleukin 1 beta	Mus musculus	78-86
23220328-3	2013	Curcumin is a fluorescent molecule with high affinity for the Abeta peptide but its low solubility limits its clinical use.	Curcumin	0-8	histocompatibility 2, class II antigen A, beta 1	Mus musculus	62-67
23220328-10	2013	FROM THE CLINICAL EDITOR: In this preclinical study, curcumin-conjugated nanoliposomes were investigated as possible diagnostics and targeted drug delivery system in Alzheimer"s disease, demonstrating strong labeling of Abeta deposits both in human tissue and in mice, and in vitro downregulation of amyloid peptide secretion and prevention of Abeta-induced toxicity.	Curcumin	53-61	histocompatibility 2, class II antigen A, beta 1	Mus musculus	220-225
23163860-8	2013	Moreover, 10 muM curcumin and 4 mM NAC significantly inhibited arecoline-induced ERK activation.	Curcumin	17-25	latexin	Homo sapiens	13-16
23163860-8	2013	Moreover, 10 muM curcumin and 4 mM NAC significantly inhibited arecoline-induced ERK activation.	Curcumin	17-25	mitogen-activated protein kinase 1	Homo sapiens	81-84
23163860-9	2013	Furthermore, 10 muM curcumin completely blocked arecoline-induced PlGF mRNA expression.	Curcumin	20-28	latexin	Homo sapiens	16-19
23163860-9	2013	Furthermore, 10 muM curcumin completely blocked arecoline-induced PlGF mRNA expression.	Curcumin	20-28	placental growth factor	Homo sapiens	66-70
23726918-0	2013	Differential anti-tumor activities of curcumin against Ras- and Src-activated human adenocarcinoma cells.	Curcumin	38-46	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	64-67
23726918-4	2013	Curcumin enhanced Erk1/2 predominantly in Ras-activated cells, but inhibited Akt and its downstream molecules (mTOR and S6K1) regardless of these oncogene activations.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	18-24
23726918-4	2013	Curcumin enhanced Erk1/2 predominantly in Ras-activated cells, but inhibited Akt and its downstream molecules (mTOR and S6K1) regardless of these oncogene activations.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	77-80
23726918-4	2013	Curcumin enhanced Erk1/2 predominantly in Ras-activated cells, but inhibited Akt and its downstream molecules (mTOR and S6K1) regardless of these oncogene activations.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	111-115
23726918-7	2013	By contrast, drastic increases of G2/M cell populations were seen in Ras-activated cells rather than Src-activated cells, suggesting a potential role of Ras/Erk1/2 activation in curcumin-induced G2/M arrest.	Curcumin	178-186	mitogen-activated protein kinase 3	Homo sapiens	157-163
23726918-8	2013	These data indicate that curcumin-induced growth inhibition would be mediated mainly by G2/M arrest in Ras-driven cells but by apoptosis induction in Src-driven cells, providing a mechanistic rationale for the potential use of curcumin in the treatment of human cancers with activated Src or Ras.	Curcumin	25-33	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	150-153
23726918-8	2013	These data indicate that curcumin-induced growth inhibition would be mediated mainly by G2/M arrest in Ras-driven cells but by apoptosis induction in Src-driven cells, providing a mechanistic rationale for the potential use of curcumin in the treatment of human cancers with activated Src or Ras.	Curcumin	25-33	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	285-288
23726918-8	2013	These data indicate that curcumin-induced growth inhibition would be mediated mainly by G2/M arrest in Ras-driven cells but by apoptosis induction in Src-driven cells, providing a mechanistic rationale for the potential use of curcumin in the treatment of human cancers with activated Src or Ras.	Curcumin	227-235	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	285-288
23802572-15	2013	Furthermore, western blot and quantitative real time PCR assays demonstrated that the curcumin induced apoptosis in GBC-SD cells by regulating the ratio of Bcl-2/Bax and activating the expression of cleaved caspase-3.	Curcumin	86-94	BCL2 apoptosis regulator	Homo sapiens	156-161
23802572-15	2013	Furthermore, western blot and quantitative real time PCR assays demonstrated that the curcumin induced apoptosis in GBC-SD cells by regulating the ratio of Bcl-2/Bax and activating the expression of cleaved caspase-3.	Curcumin	86-94	BCL2 associated X, apoptosis regulator	Homo sapiens	162-165
23802572-15	2013	Furthermore, western blot and quantitative real time PCR assays demonstrated that the curcumin induced apoptosis in GBC-SD cells by regulating the ratio of Bcl-2/Bax and activating the expression of cleaved caspase-3.	Curcumin	86-94	caspase 3	Homo sapiens	207-216
23825622-8	2013	We inferred that curcumin was capable of impacting the IL-23/IL-17A axis by inhibiting IL-1beta/IL-6 and then indirectly down-regulating IL-17A/IL-22 production.	Curcumin	17-25	interleukin 1 beta	Mus musculus	87-95
23825622-8	2013	We inferred that curcumin was capable of impacting the IL-23/IL-17A axis by inhibiting IL-1beta/IL-6 and then indirectly down-regulating IL-17A/IL-22 production.	Curcumin	17-25	interleukin 6	Mus musculus	96-100
23486648-6	2013	We showed that curcumin-treated Jurkat cells and resting T cells showed neither DNA lesions nor did they activate key proteins in the DDR signalling pathway, such as phospho-ATM and phospho-p53.	Curcumin	15-23	tumor protein p53	Homo sapiens	190-193
23890132-10	2013	Curcumin decreased chemokine (except for 288 h), TNF-alpha (except for 2 and 24 h), IL-6 (except for 2, 6 and 288 h) and iNOS (except for 144 and 288 h) mRNA levels (P &lt; 0.05).	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	49-58
23890132-10	2013	Curcumin decreased chemokine (except for 288 h), TNF-alpha (except for 2 and 24 h), IL-6 (except for 2, 6 and 288 h) and iNOS (except for 144 and 288 h) mRNA levels (P &lt; 0.05).	Curcumin	0-8	interleukin 6	Rattus norvegicus	84-88
23825622-0	2013	Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice.	Curcumin	0-8	interleukin 6	Mus musculus	91-95
23825622-6	2013	Real-time PCR showed that mRNA levels of IL-17A, IL-17F, IL-22, IL-1beta, IL-6 and TNF-alpha cytokines were decreased significantly by curcumin in ear skin, an effect similar to that of clobetasol.	Curcumin	135-143	interleukin 1 beta	Mus musculus	64-72
23825622-6	2013	Real-time PCR showed that mRNA levels of IL-17A, IL-17F, IL-22, IL-1beta, IL-6 and TNF-alpha cytokines were decreased significantly by curcumin in ear skin, an effect similar to that of clobetasol.	Curcumin	135-143	interleukin 6	Mus musculus	74-78
23825622-6	2013	Real-time PCR showed that mRNA levels of IL-17A, IL-17F, IL-22, IL-1beta, IL-6 and TNF-alpha cytokines were decreased significantly by curcumin in ear skin, an effect similar to that of clobetasol.	Curcumin	135-143	tumor necrosis factor	Mus musculus	83-92
26770672-3	2013	Curcumin activated caspase-3 and the cleavage of the two cytoskeletal proteins lamin B1 and vimentin.	Curcumin	0-8	caspase 3	Homo sapiens	19-28
24079252-11	2013	RT-PCR test showed that curcumin can activate the expression of Bax and Caspase-3, inhibit the expression of Bcl-2 and Bcl-xL at the mRNA level.	Curcumin	24-32	BCL2 associated X, apoptosis regulator	Homo sapiens	64-67
24079252-11	2013	RT-PCR test showed that curcumin can activate the expression of Bax and Caspase-3, inhibit the expression of Bcl-2 and Bcl-xL at the mRNA level.	Curcumin	24-32	caspase 3	Homo sapiens	72-81
24079252-11	2013	RT-PCR test showed that curcumin can activate the expression of Bax and Caspase-3, inhibit the expression of Bcl-2 and Bcl-xL at the mRNA level.	Curcumin	24-32	BCL2 apoptosis regulator	Homo sapiens	109-114
24079252-11	2013	RT-PCR test showed that curcumin can activate the expression of Bax and Caspase-3, inhibit the expression of Bcl-2 and Bcl-xL at the mRNA level.	Curcumin	24-32	BCL2 like 1	Homo sapiens	119-125
23840617-3	2013	Treatment with curcumin attenuated alloreactive T cell proliferation and inhibited the production of interferon (IFN)-gamma and interleukin (IL)-17.	Curcumin	15-23	interferon gamma	Mus musculus	101-123
23840617-7	2013	The IFN-gamma-expressing CD4(+) splenocytes and IFN-gamma-expressing lymph node cells were dramatically decreased in curcumin-treated mice.	Curcumin	117-125	interferon gamma	Mus musculus	4-13
23840617-7	2013	The IFN-gamma-expressing CD4(+) splenocytes and IFN-gamma-expressing lymph node cells were dramatically decreased in curcumin-treated mice.	Curcumin	117-125	interferon gamma	Mus musculus	48-57
23802320-0	2013	Retraction notice to "Transferrin-conjugated curcumin-loaded superparamagnetic iron oxide nanoparticles induce augmented cellular uptake and apoptosis in K562 cells" [Acta Biomaterialia 8 (2011) 704-719].	Curcumin	45-53	transferrin	Homo sapiens	22-33
23576578-7	2013	Curcumin, an inhibitor of NF-kappaB-induced transcription, blocked ANG II-induced COX-2 protein expression without altering AT1AR internalization, ANG II-induced p65 NF-kappaB nuclear localization, or p42/44 ERK activation.	Curcumin	0-8	angiotensinogen	Rattus norvegicus	67-73
22350026-3	2013	We previously reported that curcumin reduced uterine LMS cell proliferation by targeting the AKT-mTOR pathway.	Curcumin	28-36	AKT serine/threonine kinase 1	Homo sapiens	93-96
23574162-5	2013	Curcumin had also been reported previously to function as a cannabinoid CB1 receptor inverse agonist/antagonist.	Curcumin	0-8	cannabinoid receptor 1	Homo sapiens	72-75
23532091-3	2013	We previously demonstrated that curcumin reduced uterine LMS cell proliferation by targeting the AKT-mTOR pathway and activating apoptosis.	Curcumin	32-40	AKT serine/threonine kinase 1	Homo sapiens	97-100
23532091-3	2013	We previously demonstrated that curcumin reduced uterine LMS cell proliferation by targeting the AKT-mTOR pathway and activating apoptosis.	Curcumin	32-40	mechanistic target of rapamycin kinase	Homo sapiens	101-105
23621850-8	2013	These results demonstrated that curcumin induced RANK gene reactivation through epigenetic modification in human glioblastoma cells, and that STAT3 is involved in RANK promoter hypermethylation and epigenetic silencing, thus allowing for further applications of curcumin epigenetic therapy in glioma and therapeutic implications of STAT3 in human glioblastoma.	Curcumin	262-270	signal transducer and activator of transcription 3	Homo sapiens	142-147
23500387-0	2013	Curcumin attenuates allergic airway inflammation by regulation of CD4+CD25+ regulatory T cells (Tregs)/Th17 balance in ovalbumin-sensitized mice.	Curcumin	0-8	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	119-128
23500387-1	2013	The present study aimed to determine the protective effects and the underlying mechanisms of curcumin on ovalbumin (OVA)-induced allergic inflammation in a mouse model of allergic asthma.	Curcumin	93-101	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	105-114
23500387-5	2013	Our study demonstrated that curcumin inhibited OVA-induced increases in eosinophil count; interleukin (IL)-17A level were recovered in bronchoalveolar lavage fluid increased IL-10 level in bronchoalveolar lavage fluid.	Curcumin	28-36	interleukin 10	Mus musculus	174-179
23500387-8	2013	The results in vivo show ovalbumin-induced significantly broke Treg/Th17 balance; curcumin treatments markedly attenuated the inflammatory in asthma model by regulating Treg/Th17 balance.	Curcumin	82-90	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	25-34
23532091-10	2013	Curcumin increased extracellular signal-regulated kinase 1/2 activity in both SKN and SK-UT-1 cells, whereas PD98059, an MEK1 inhibitor, inhibited both the extracellular signal-regulated kinase 1/2 pathway and curcumin-induced autophagy.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	19-60
23532091-10	2013	Curcumin increased extracellular signal-regulated kinase 1/2 activity in both SKN and SK-UT-1 cells, whereas PD98059, an MEK1 inhibitor, inhibited both the extracellular signal-regulated kinase 1/2 pathway and curcumin-induced autophagy.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	19-58
22350026-3	2013	We previously reported that curcumin reduced uterine LMS cell proliferation by targeting the AKT-mTOR pathway.	Curcumin	28-36	mechanistic target of rapamycin kinase	Homo sapiens	97-101
22350026-10	2013	Antibody against EGCG cell surface receptor, 67-kDa laminin receptor (67LR), was used to investigate the role of the receptor in curcumin"s increased potency by EGCG.	Curcumin	129-137	ribosomal protein SA	Homo sapiens	45-68
22350026-10	2013	Antibody against EGCG cell surface receptor, 67-kDa laminin receptor (67LR), was used to investigate the role of the receptor in curcumin"s increased potency by EGCG.	Curcumin	129-137	ribosomal protein SA	Homo sapiens	70-74
22350026-15	2013	CONCLUSIONS: EGCG significantly lowered the concentration of curcumin required to inhibit the AKT-mTOR pathway, reduce cell proliferation and induce apoptosis in uterine LMS cells by enhancing intracellular incorporation of curcumin, but the process was independent of 67LR.	Curcumin	61-69	AKT serine/threonine kinase 1	Homo sapiens	94-97
22350026-15	2013	CONCLUSIONS: EGCG significantly lowered the concentration of curcumin required to inhibit the AKT-mTOR pathway, reduce cell proliferation and induce apoptosis in uterine LMS cells by enhancing intracellular incorporation of curcumin, but the process was independent of 67LR.	Curcumin	61-69	mechanistic target of rapamycin kinase	Homo sapiens	98-102
22350026-15	2013	CONCLUSIONS: EGCG significantly lowered the concentration of curcumin required to inhibit the AKT-mTOR pathway, reduce cell proliferation and induce apoptosis in uterine LMS cells by enhancing intracellular incorporation of curcumin, but the process was independent of 67LR.	Curcumin	61-69	ribosomal protein SA	Homo sapiens	269-273
23001851-8	2013	Concurrent use of curcumin with bleomycin decreased caspase activities and Bax and Cyt-c levels compared to their separate effects in NCCIT cells.	Curcumin	18-26	BCL2 associated X, apoptosis regulator	Homo sapiens	75-78
25337545-0	2013	Curcumin Inhibits STAT3 Signaling in the Colon of Dextran Sulfate Sodium-treated Mice.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	18-23
25337545-5	2013	Our study revealed that administration of curcumin significantly attenuated the severity of DSS-induced colitis and STAT3 signaling in mouse colon.	Curcumin	42-50	signal transducer and activator of transcription 3	Mus musculus	116-121
25337545-6	2013	The levels of the cell cycle regulators CDK4 and cylinD1 were significantly reduced by curcumin administration.	Curcumin	87-95	cyclin-dependent kinase 4	Mus musculus	40-44
25337545-7	2013	Moreover, the expression of p53, which is an upstream regulator of the CDK4-cylinD1 complex, was inhibited by curcumin treatment.	Curcumin	110-118	cyclin-dependent kinase 4	Mus musculus	71-75
23730211-0	2013	Curcumin triggers p16-dependent senescence in active breast cancer-associated fibroblasts and suppresses their paracrine procarcinogenic effects.	Curcumin	0-8	cyclin dependent kinase inhibitor 2A	Homo sapiens	18-21
23686430-0	2013	Curcumin induces apoptosis in human colorectal carcinoma (HCT-15) cells by regulating expression of Prp4 and p53.	Curcumin	0-8	tumor protein p53	Homo sapiens	109-112
23686430-4	2013	Hoechst 33342 and DCFHDA staining revealed morphological and biochemical features of apoptosis as well as ROS generation in HCT-15 cells treated with 30 and 50 muM curcumin.	Curcumin	164-172	latexin	Homo sapiens	160-163
23686430-6	2013	Western blot analysis revealed that curcumin treatment activated caspase-3 and decreased expression of p53 and Prp4B in a time-dependent manner.	Curcumin	36-44	caspase 3	Homo sapiens	65-74
23686430-6	2013	Western blot analysis revealed that curcumin treatment activated caspase-3 and decreased expression of p53 and Prp4B in a time-dependent manner.	Curcumin	36-44	tumor protein p53	Homo sapiens	103-106
23686430-7	2013	Transfection of HCT-15 cells with Prp4B clone perturbed the growth inhibition induced by 30 muM curcumin.	Curcumin	96-104	latexin	Homo sapiens	92-95
23730211-4	2013	We have shown that curcumin treatment upregulates p16(INK4A) and other tumor suppressor proteins while inactivates the JAK2/STAT3 pathway.	Curcumin	19-27	cyclin dependent kinase inhibitor 2A	Homo sapiens	50-53
23730211-4	2013	We have shown that curcumin treatment upregulates p16(INK4A) and other tumor suppressor proteins while inactivates the JAK2/STAT3 pathway.	Curcumin	19-27	cyclin dependent kinase inhibitor 2A	Homo sapiens	54-59
23730211-4	2013	We have shown that curcumin treatment upregulates p16(INK4A) and other tumor suppressor proteins while inactivates the JAK2/STAT3 pathway.	Curcumin	19-27	signal transducer and activator of transcription 3	Homo sapiens	124-129
23730211-6	2013	Furthermore, curcumin suppressed the expression/secretion of stromal cell-derived factor-1 (SDF-1), interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2), MMP-9, and transforming growth factor-beta, which impeded their paracrine procarcinogenic potential.	Curcumin	13-21	interleukin 6	Homo sapiens	100-113
23730211-6	2013	Furthermore, curcumin suppressed the expression/secretion of stromal cell-derived factor-1 (SDF-1), interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2), MMP-9, and transforming growth factor-beta, which impeded their paracrine procarcinogenic potential.	Curcumin	13-21	interleukin 6	Homo sapiens	115-119
23730211-9	2013	Importantly, this curcumin-related senescence was p16(INK4A)-dependent and occurred with no associated inflammatory secretory phenotype.	Curcumin	18-26	cyclin dependent kinase inhibitor 2A	Homo sapiens	50-53
23730211-9	2013	Importantly, this curcumin-related senescence was p16(INK4A)-dependent and occurred with no associated inflammatory secretory phenotype.	Curcumin	18-26	cyclin dependent kinase inhibitor 2A	Homo sapiens	54-59
23563640-8	2013	The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P&lt;0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P&lt;0.01, respectively).	Curcumin	56-64	transforming growth factor beta 1	Homo sapiens	4-13
23638900-0	2013	Curcumin acts via transient receptor potential vanilloid-1 receptors to inhibit gut nociception and reverses visceral hyperalgesia.	Curcumin	0-8	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	18-58
23638900-2	2013	In this study, we explored the possibility that curcumin inhibit visceral nociception via antagonizing the transient receptor potential vanilloid-1 (TRPV1) receptor.	Curcumin	48-56	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	107-147
23638900-2	2013	In this study, we explored the possibility that curcumin inhibit visceral nociception via antagonizing the transient receptor potential vanilloid-1 (TRPV1) receptor.	Curcumin	48-56	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	149-154
23638900-6	2013	In the mouse jejunum, the mesenteric afferent nerve response to ramp distension was attenuated by curcumin (3, 10 mumol L(-1) ), an effect that was significantly reduced in TRPV1 KO mice compared with wild-type (WT) controls.	Curcumin	98-106	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	173-178
23638900-10	2013	CONCLUSIONS &amp; INFERENCES: Our results provide strong evidence that curcumin inhibit visceral nociception via antagonizing TRPV1 and may be a promising lead for the treatment of functional gastrointestinal diseases.	Curcumin	71-79	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	126-131
23563640-8	2013	The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P&lt;0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P&lt;0.01, respectively).	Curcumin	93-101	transforming growth factor beta 1	Homo sapiens	4-13
23563640-8	2013	The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P&lt;0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P&lt;0.01, respectively).	Curcumin	93-101	transforming growth factor beta 1	Homo sapiens	126-135
23563640-8	2013	The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P&lt;0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P&lt;0.01, respectively).	Curcumin	93-101	transforming growth factor beta 1	Homo sapiens	4-13
23563640-8	2013	The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P&lt;0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P&lt;0.01, respectively).	Curcumin	93-101	transforming growth factor beta 1	Homo sapiens	126-135
23563640-9	2013	The expression level of E-cadherin in the curcumin-treated group was significantly increased compared with that in the control group (P&lt;0.01).	Curcumin	42-50	cadherin 1	Homo sapiens	24-34
23563640-12	2013	Curcumin significantly inhibited the invasion and migration of TGF-beta1-stimulated PANC-1 cells.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	63-72
23563640-13	2013	These results indicate that curcumin can inhibit the proliferation of TGF-beta1-stimulated PANC-1 cells, it can induce apoptosis, and reverse the EMT.	Curcumin	28-36	transforming growth factor beta 1	Homo sapiens	70-79
24216994-4	2013	An inhibitor to MEK or curcumin significantly suppressed the phosphorylation of ERK1/2 and expression of VEGF.	Curcumin	23-31	mitogen-activated protein kinase 3	Homo sapiens	80-86
23980364-10	2013	CONCLUSION: Curcumin combined FOLFOX could significantly inhibit the proliferation of BGC-823 cells possibly via promoting Bax expression and Caspase-3 activity, inhibiting Bcl-2 expression, thus inducing apoptosis.	Curcumin	12-20	BCL2 associated X, apoptosis regulator	Homo sapiens	123-126
23980364-10	2013	CONCLUSION: Curcumin combined FOLFOX could significantly inhibit the proliferation of BGC-823 cells possibly via promoting Bax expression and Caspase-3 activity, inhibiting Bcl-2 expression, thus inducing apoptosis.	Curcumin	12-20	caspase 3	Homo sapiens	142-151
23980364-10	2013	CONCLUSION: Curcumin combined FOLFOX could significantly inhibit the proliferation of BGC-823 cells possibly via promoting Bax expression and Caspase-3 activity, inhibiting Bcl-2 expression, thus inducing apoptosis.	Curcumin	12-20	BCL2 apoptosis regulator	Homo sapiens	173-178
23875250-0	2013	Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor.	Curcumin	0-8	NFKB inhibitor alpha	Homo sapiens	106-118
23875250-6	2013	Mechanistically, we found that curcumin upregulated the protein level of NF-kappaB inhibitor IkappaBalpha and downregulated protein levels of c-Jun and AR.	Curcumin	31-39	NFKB inhibitor alpha	Homo sapiens	93-105
24216994-4	2013	An inhibitor to MEK or curcumin significantly suppressed the phosphorylation of ERK1/2 and expression of VEGF.	Curcumin	23-31	vascular endothelial growth factor A	Homo sapiens	105-109
25206431-6	2013	Curcumin is neuroprotective against gp120 V3 loop-induced neuronal damage by inhibiting the activation of L-type calcium currents, relieving intracellular Ca(2+) overload, promoting Bcl-2 expression, and inhibiting Bax activation.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	182-187
25206431-6	2013	Curcumin is neuroprotective against gp120 V3 loop-induced neuronal damage by inhibiting the activation of L-type calcium currents, relieving intracellular Ca(2+) overload, promoting Bcl-2 expression, and inhibiting Bax activation.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	215-218
23494805-0	2013	Curcumin attenuates cyclooxygenase-2 expression via inhibition of the NF-kappaB pathway in lipopolysaccharide-stimulated human gingival fibroblasts.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	20-36
23671702-0	2013	Curcumin nanoparticles ameliorate ICAM-1 expression in TNF-alpha-treated lung epithelial cells through p47 (phox) and MAPKs/AP-1 pathways.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	55-64
23645731-4	2013	RESULTS: Curcumin exhibited dose-dependent antitumor activity against HAG-1 cells, arresting the cells in G2/M phase, with progressive expansion of the apoptotic cell population.	Curcumin	9-17	thioredoxin domain containing 12	Homo sapiens	70-75
23645731-5	2013	Upon curcumin treatment, AKT activation was substantially suppressed, with subsequent reduction of activities of mammalian target of rapamycin (mTOR) and its downstream molecules S6 kinase-1 (S6K1) and elF4E-binding protein-1 (4E-BP1), but constitutive activity of extracellular signal-regulated kinase (ERK1/2) was clearly enhanced.	Curcumin	5-13	AKT serine/threonine kinase 1	Homo sapiens	25-28
23645731-5	2013	Upon curcumin treatment, AKT activation was substantially suppressed, with subsequent reduction of activities of mammalian target of rapamycin (mTOR) and its downstream molecules S6 kinase-1 (S6K1) and elF4E-binding protein-1 (4E-BP1), but constitutive activity of extracellular signal-regulated kinase (ERK1/2) was clearly enhanced.	Curcumin	5-13	mechanistic target of rapamycin kinase	Homo sapiens	113-142
23645731-5	2013	Upon curcumin treatment, AKT activation was substantially suppressed, with subsequent reduction of activities of mammalian target of rapamycin (mTOR) and its downstream molecules S6 kinase-1 (S6K1) and elF4E-binding protein-1 (4E-BP1), but constitutive activity of extracellular signal-regulated kinase (ERK1/2) was clearly enhanced.	Curcumin	5-13	mechanistic target of rapamycin kinase	Homo sapiens	144-148
23645731-5	2013	Upon curcumin treatment, AKT activation was substantially suppressed, with subsequent reduction of activities of mammalian target of rapamycin (mTOR) and its downstream molecules S6 kinase-1 (S6K1) and elF4E-binding protein-1 (4E-BP1), but constitutive activity of extracellular signal-regulated kinase (ERK1/2) was clearly enhanced.	Curcumin	5-13	mitogen-activated protein kinase 3	Homo sapiens	304-310
23645731-6	2013	Curcumin reduced the expression and phosphorylation of anti-apoptotic Bcl-2, but did not affect the expressions of pro-apoptotic Bax and anti-apoptotic nuclear factor (NF-kappaB).	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	70-75
23645731-7	2013	CONCLUSION: These results suggest that curcumin induces G2/M arrest and apoptosis through multiple mechanisms involving enhanced mitogen-activated protein (MAP) kinase activity, reduced AKT-mTOR activity, and reduced Bcl-2 function.	Curcumin	39-47	AKT serine/threonine kinase 1	Homo sapiens	186-189
23645731-7	2013	CONCLUSION: These results suggest that curcumin induces G2/M arrest and apoptosis through multiple mechanisms involving enhanced mitogen-activated protein (MAP) kinase activity, reduced AKT-mTOR activity, and reduced Bcl-2 function.	Curcumin	39-47	mechanistic target of rapamycin kinase	Homo sapiens	190-194
23645731-7	2013	CONCLUSION: These results suggest that curcumin induces G2/M arrest and apoptosis through multiple mechanisms involving enhanced mitogen-activated protein (MAP) kinase activity, reduced AKT-mTOR activity, and reduced Bcl-2 function.	Curcumin	39-47	BCL2 apoptosis regulator	Homo sapiens	217-222
23353183-3	2013	Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation.	Curcumin	70-78	mitogen-activated protein kinase 1	Homo sapiens	20-23
23353183-3	2013	Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation.	Curcumin	70-78	mitogen-activated protein kinase 14	Homo sapiens	27-30
23353183-3	2013	Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation.	Curcumin	70-78	mitogen-activated protein kinase 8	Homo sapiens	31-34
23353183-3	2013	Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation.	Curcumin	70-78	AKT serine/threonine kinase 1	Homo sapiens	205-208
23353183-3	2013	Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation.	Curcumin	115-123	mitogen-activated protein kinase 1	Homo sapiens	20-23
23353183-3	2013	Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation.	Curcumin	115-123	mitogen-activated protein kinase 14	Homo sapiens	27-30
23353183-3	2013	Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation.	Curcumin	115-123	mitogen-activated protein kinase 8	Homo sapiens	31-34
23353183-3	2013	Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation.	Curcumin	115-123	AKT serine/threonine kinase 1	Homo sapiens	205-208
23353183-6	2013	At the later incubation period (24h), cytotoxicity caused by curcumin peaked, at which time survival or proliferation signals, such as phosphorylated Akt and phosphorylated ERK, was almost completely diminished.	Curcumin	61-69	AKT serine/threonine kinase 1	Homo sapiens	150-153
23353183-6	2013	At the later incubation period (24h), cytotoxicity caused by curcumin peaked, at which time survival or proliferation signals, such as phosphorylated Akt and phosphorylated ERK, was almost completely diminished.	Curcumin	61-69	mitogen-activated protein kinase 1	Homo sapiens	173-176
23313051-4	2013	CCN4-induced VCAM-1 expression was attenuated by alphavbeta5 or alpha6beta1 integrin antibody, Syk inhibitor, PKCdelta inhibitor (rottlerin), JNK inhibitor (SP600125), and AP-1 inhibitors (curcumin and tanshinone).	Curcumin	189-197	vascular cell adhesion molecule 1	Homo sapiens	13-19
23353183-2	2013	At higher concentrations, curcumin induced ROS production leading to JNK and p38 phosphorylation in DU-145 prostate cancer cells.	Curcumin	26-34	mitogen-activated protein kinase 8	Homo sapiens	69-72
23353183-2	2013	At higher concentrations, curcumin induced ROS production leading to JNK and p38 phosphorylation in DU-145 prostate cancer cells.	Curcumin	26-34	mitogen-activated protein kinase 14	Homo sapiens	77-80
23494805-0	2013	Curcumin attenuates cyclooxygenase-2 expression via inhibition of the NF-kappaB pathway in lipopolysaccharide-stimulated human gingival fibroblasts.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	70-79
23494805-8	2013	P. gingivalis LPS activated NF-kappaB-dependent transcription in HGFs, which were also downregulated by pretreatment with curcumin.	Curcumin	122-130	nuclear factor kappa B subunit 1	Homo sapiens	28-37
23494805-9	2013	Therefore, curcumin can inhibit P. gingivalis LPS-induced COX-2 expression, which may be due to the inhibition of the NF-kappaB pathway.	Curcumin	11-19	nuclear factor kappa B subunit 1	Homo sapiens	118-127
23778405-11	2013	The expression of the multidrug resistance protein 1 and survivin genes was significantly reduced in xenografts of curcumin-treated mice and mice treated with both curcumin and vincristine relative to control mice.	Curcumin	115-123	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	22-52
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	15-23	B cell leukemia/lymphoma 2	Mus musculus	72-77
23778405-11	2013	The expression of the multidrug resistance protein 1 and survivin genes was significantly reduced in xenografts of curcumin-treated mice and mice treated with both curcumin and vincristine relative to control mice.	Curcumin	164-172	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	22-52
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	100-108	B cell leukemia/lymphoma 2	Mus musculus	72-77
23740450-8	2013	Curcumin attenuated loss of TH-IR fibers, diminished activation of astrocytes and microglia, and sustained SOD1 level in the lesioned striatum.	Curcumin	0-8	superoxide dismutase 1, soluble	Mus musculus	107-111
23614750-0	2013	Curcumin inhibits UVB-induced matrix metalloproteinase-1/3 expression by suppressing the MAPK-p38/JNK pathways in human dermal fibroblasts.	Curcumin	0-8	matrix metallopeptidase 13	Homo sapiens	30-58
23501115-4	2013	Besides, compounds showed higher activity of inhibiting AChE-induced amyloid-beta (Abeta) aggregation than curcumin, higher anti-oxidative activity than Trolox, and could also be good metal chelators.	Curcumin	107-115	acetylcholinesterase (Cartwright blood group)	Homo sapiens	56-60
23614750-0	2013	Curcumin inhibits UVB-induced matrix metalloproteinase-1/3 expression by suppressing the MAPK-p38/JNK pathways in human dermal fibroblasts.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	94-97
23740450-9	2013	CONCLUSIONS: These results suggest that curcumin counteracts the neurotoxicity of 6-OHDA through its anti-inflammatory properties (inhibition of glial response) and preservation of SOD1 expression.	Curcumin	40-48	superoxide dismutase 1, soluble	Mus musculus	181-185
23614750-0	2013	Curcumin inhibits UVB-induced matrix metalloproteinase-1/3 expression by suppressing the MAPK-p38/JNK pathways in human dermal fibroblasts.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	98-101
23614750-4	2013	In this study, we investigated the inhibitory effects of curcumin on matrix metalloproteinase (MMP)-1 and MMP-3 expression in human dermal fibroblast cells.	Curcumin	57-65	matrix metallopeptidase 3	Homo sapiens	106-111
23541743-0	2013	The effect of curcumin on sepsis-induced acute lung injury in a rat model through the inhibition of the TGF-beta1/SMAD3 pathway.	Curcumin	14-22	transforming growth factor, beta 1	Rattus norvegicus	104-113
23614750-5	2013	Western blot analysis revealed that curcumin inhibited ultraviolet (UV) B-induced MMP-1 and MMP-3 expression.	Curcumin	36-44	matrix metallopeptidase 3	Homo sapiens	92-97
23614750-8	2013	Additionally, curcumin strongly repressed the UVB-induced phosphorylation of p38 and c-Jun N-terminal kinase.	Curcumin	14-22	mitogen-activated protein kinase 14	Homo sapiens	77-80
23541743-0	2013	The effect of curcumin on sepsis-induced acute lung injury in a rat model through the inhibition of the TGF-beta1/SMAD3 pathway.	Curcumin	14-22	SMAD family member 3	Rattus norvegicus	114-119
23541743-6	2013	24h after the initial treatment, real-time PCR and Western blot analysis showed that the expression of TGF-beta1 and SMAD3-dependent signaling pathway was significantly decreased in the curcumin-treated group than other control groups (P&lt;0.05).	Curcumin	186-194	transforming growth factor, beta 1	Rattus norvegicus	103-112
23541743-6	2013	24h after the initial treatment, real-time PCR and Western blot analysis showed that the expression of TGF-beta1 and SMAD3-dependent signaling pathway was significantly decreased in the curcumin-treated group than other control groups (P&lt;0.05).	Curcumin	186-194	SMAD family member 3	Rattus norvegicus	117-122
23541743-7	2013	Therefore, curcumin played a protective role in sepsis-induced ALI, possibly through the inhibition of the expression of TGF-beta1/SMAD3 pathway which may provide a new strategy for the treatment of sepsis-induced ALI.	Curcumin	11-19	transforming growth factor, beta 1	Rattus norvegicus	121-130
23541743-7	2013	Therefore, curcumin played a protective role in sepsis-induced ALI, possibly through the inhibition of the expression of TGF-beta1/SMAD3 pathway which may provide a new strategy for the treatment of sepsis-induced ALI.	Curcumin	11-19	SMAD family member 3	Rattus norvegicus	131-136
23245727-7	2013	Serum TNF-alpha concentration in the cisplatin + curcumin group significantly decreased compared with that in the cisplatin group.	Curcumin	49-57	tumor necrosis factor	Mus musculus	6-15
23245727-8	2013	Renal TNF-alpha and MCP-1 concentrations and ICAM-1 mRNA expression in kidney in the cisplatin + curcumin group also significantly decreased compared with those in the cisplatin group.	Curcumin	97-105	tumor necrosis factor	Mus musculus	6-15
22841393-6	2013	Curcumin treatment induced CAMP promoter activity from a luciferase reporter construct lacking the VDR binding site and did not increase binding of the VDR to the CAMP promoter as determined by chromatin immunoprecipitation assays.	Curcumin	0-8	cathelicidin antimicrobial peptide	Homo sapiens	27-31
22841393-7	2013	These findings indicate that induction of CAMP by curcumin occurs through a vitamin D receptor-independent manner.	Curcumin	50-58	cathelicidin antimicrobial peptide	Homo sapiens	42-46
22841393-0	2013	Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway.	Curcumin	0-8	cathelicidin antimicrobial peptide	Homo sapiens	23-57
23545262-0	2013	DAPK1 modulates a curcumin-induced G2/M arrest and apoptosis by regulating STAT3, NF-kappaB, and caspase-3 activation.	Curcumin	18-26	death associated protein kinase 1	Homo sapiens	0-5
22290509-5	2013	Increasing the concentration of curcumin from 10 to 20 microM enhanced the growth inhibitory effects of the combination in SkBr3 and 435eB breast cancer cells, which was accompanied by decreased viability along with decreased phosphorylation of ERK and Akt.	Curcumin	32-40	mitogen-activated protein kinase 1	Homo sapiens	245-248
22290509-5	2013	Increasing the concentration of curcumin from 10 to 20 microM enhanced the growth inhibitory effects of the combination in SkBr3 and 435eB breast cancer cells, which was accompanied by decreased viability along with decreased phosphorylation of ERK and Akt.	Curcumin	32-40	AKT serine/threonine kinase 1	Homo sapiens	253-256
22290509-11	2013	We conclude that p53 independent apoptosis induced by combining curcumin and TSA involves JNK activation.	Curcumin	64-72	tumor protein p53	Homo sapiens	17-20
23545262-0	2013	DAPK1 modulates a curcumin-induced G2/M arrest and apoptosis by regulating STAT3, NF-kappaB, and caspase-3 activation.	Curcumin	18-26	signal transducer and activator of transcription 3	Homo sapiens	75-80
23545262-0	2013	DAPK1 modulates a curcumin-induced G2/M arrest and apoptosis by regulating STAT3, NF-kappaB, and caspase-3 activation.	Curcumin	18-26	nuclear factor kappa B subunit 1	Homo sapiens	82-91
23545262-0	2013	DAPK1 modulates a curcumin-induced G2/M arrest and apoptosis by regulating STAT3, NF-kappaB, and caspase-3 activation.	Curcumin	18-26	caspase 3	Homo sapiens	97-106
23545262-2	2013	In this study, we found that the tumor suppressor death-associated protein kinase 1 (DAPK1) plays a vital role in the anti-carcinogenic effects of curcumin.	Curcumin	147-155	death associated protein kinase 1	Homo sapiens	85-90
23545262-3	2013	We found that curcumin increased DAPK1 expression at the mRNA and protein levels in U251 cells, and that the siRNA-mediated knockdown of DAPK1 attenuated the curcumin-induced inhibition of STAT3 and NF-kappaB.	Curcumin	14-22	death associated protein kinase 1	Homo sapiens	33-38
23545262-3	2013	We found that curcumin increased DAPK1 expression at the mRNA and protein levels in U251 cells, and that the siRNA-mediated knockdown of DAPK1 attenuated the curcumin-induced inhibition of STAT3 and NF-kappaB.	Curcumin	158-166	death associated protein kinase 1	Homo sapiens	137-142
23545262-3	2013	We found that curcumin increased DAPK1 expression at the mRNA and protein levels in U251 cells, and that the siRNA-mediated knockdown of DAPK1 attenuated the curcumin-induced inhibition of STAT3 and NF-kappaB.	Curcumin	158-166	signal transducer and activator of transcription 3	Homo sapiens	189-194
23545262-3	2013	We found that curcumin increased DAPK1 expression at the mRNA and protein levels in U251 cells, and that the siRNA-mediated knockdown of DAPK1 attenuated the curcumin-induced inhibition of STAT3 and NF-kappaB.	Curcumin	158-166	nuclear factor kappa B subunit 1	Homo sapiens	199-208
23545262-4	2013	Moreover, DAPK1 suppression diminished curcumin-induced caspase-3 activation.	Curcumin	39-47	death associated protein kinase 1	Homo sapiens	10-15
23545262-4	2013	Moreover, DAPK1 suppression diminished curcumin-induced caspase-3 activation.	Curcumin	39-47	caspase 3	Homo sapiens	56-65
23545262-5	2013	In addition, we confirmed that DAPK1 was required for a curcumin-induced G2/M cell cycle arrest and apoptosis.	Curcumin	56-64	death associated protein kinase 1	Homo sapiens	31-36
23545262-6	2013	Thus, DAPK1 is involved in curcumin-mediated death pathways.	Curcumin	27-35	death associated protein kinase 1	Homo sapiens	6-11
23658623-0	2013	Curcumin inhibits CD4(+) T cell activation, but augments CD69 expression and TGF-beta1-mediated generation of regulatory T cells at late phase.	Curcumin	0-8	CD4 molecule	Homo sapiens	18-21
23184090-6	2013	Furthermore, the effect of curcumin on IFNgamma-induced BAFF expression and transcriptional activation in B lymphocytes was determined by qPCR, Western Blot, and luciferase assay.	Curcumin	27-35	interferon gamma	Mus musculus	39-47
23584140-6	2013	Further, incubation of cells with combinations of limonoids and curcumin resulted in elevation of total cellular caspase-3 activity by 3.5-4.0 fold along with a 2- to 4-fold increase in the Bax/Bcl-2 ratio.	Curcumin	64-72	caspase 3	Homo sapiens	113-122
23584140-6	2013	Further, incubation of cells with combinations of limonoids and curcumin resulted in elevation of total cellular caspase-3 activity by 3.5-4.0 fold along with a 2- to 4-fold increase in the Bax/Bcl-2 ratio.	Curcumin	64-72	BCL2 associated X, apoptosis regulator	Homo sapiens	190-193
23584140-6	2013	Further, incubation of cells with combinations of limonoids and curcumin resulted in elevation of total cellular caspase-3 activity by 3.5-4.0 fold along with a 2- to 4-fold increase in the Bax/Bcl-2 ratio.	Curcumin	64-72	BCL2 apoptosis regulator	Homo sapiens	194-199
23584140-7	2013	The expression of pro-caspase-3 and its cleaved products in cells treated with curcumin (individually or combination) indicates higher potency of the combination to induce apoptosis.	Curcumin	79-87	caspase 3	Homo sapiens	18-31
23364261-9	2013	We propose that using curcumin to reinforce the naturally occurring Prdx6 expression and attenuate ROS-based ER stress and NF-kappaB-mediated aberrant signaling improves cell survival and may provide an avenue to treat and/or postpone diseases associated with ROS or ER stress.	Curcumin	22-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	123-132
23564771-0	2013	Effects of pyridine analogs of curcumin on growth, apoptosis and NF-kappaB activity in prostate cancer PC-3 cells.	Curcumin	31-39	nuclear factor kappa B subunit 1	Homo sapiens	65-74
23564771-4	2013	Only pyridine analogs of curcumin with a tetrahydrothiopyrane-4-one linker (FN compounds) exhibited a strong inhibitory effect on growth and a strong stimulatory effect on apoptosis at low concentrations (&lt;= 1 muM).	Curcumin	25-33	latexin	Homo sapiens	213-216
23234806-7	2013	RESULTS: Curcumin selectively eliminates a variety of HPV(+) cervical cancer cells (HeLa, ME-180, SiHa, and SW756), suppresses the transforming antigen E6, dramatically inhibits the expression of the pro-cancer protein epidermal growth factor receptor (EGFR), and concomitantly induces p53.	Curcumin	9-17	epidermal growth factor receptor	Homo sapiens	253-257
23224523-0	2013	Role of TGF-beta signaling in curcumin-mediated inhibition of tumorigenicity of human lung cancer cells.	Curcumin	30-38	transforming growth factor beta 1	Homo sapiens	8-16
23224523-4	2013	Here, we investigate the role of curcumin on TGF-beta signaling, and whether TGF-beta signaling is involved in the antitumor activities of curcumin.	Curcumin	139-147	transforming growth factor beta 1	Homo sapiens	77-85
23224523-5	2013	METHODS: Human non-small cell lung cancer (NSCLC) cell lines, ACC-LC-176 (without TGF-beta signaling), H358, and A549 (with TGF-beta signaling) were treated with curcumin to determine cell growth, apoptosis, and tumorigenicity.	Curcumin	162-170	transforming growth factor beta 1	Homo sapiens	124-132
23224523-7	2013	We also tested the effect of curcumin on TGF-beta/Smad signaling by western blotting and by luciferase assays.	Curcumin	29-37	transforming growth factor beta 1	Homo sapiens	41-49
23224523-10	2013	Curcumin inhibited TGF-beta-induced Smad2/3 phosphorylation and transcription in H358 and A549 cells, but not in ACC-LC-176 cells.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	19-27
23658623-0	2013	Curcumin inhibits CD4(+) T cell activation, but augments CD69 expression and TGF-beta1-mediated generation of regulatory T cells at late phase.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	77-86
23658623-2	2013	Although CD4(+) T cells have been implicated in the pathogenesis of chronic inflammation, whether curcumin directly regulates CD4(+) T cells has not been definitively established.	Curcumin	98-106	CD4 molecule	Homo sapiens	126-129
23658623-3	2013	Here, we showed curcumin-mediated regulation of CD2/CD3/CD28-initiated CD4(+) T cell activation in vitro.	Curcumin	16-24	CD4 molecule	Homo sapiens	71-74
23658623-5	2013	We found that curcumin suppresses CD2/CD3/CD28-initiated CD4(+) T cell activation by inhibiting cell proliferation, differentiation and cytokine production.	Curcumin	14-22	CD4 molecule	Homo sapiens	57-60
23658623-6	2013	On the other hand, curcumin attenuated the spontaneous decline of CD69 expression and indirectly increased expression of CCR7, L-selectin and Transforming growth factor-beta1 (TGF-beta1) at the late phase of CD2/CD3/CD28-initiated T cell activation.	Curcumin	19-27	C-C motif chemokine receptor 7	Homo sapiens	121-125
23658623-6	2013	On the other hand, curcumin attenuated the spontaneous decline of CD69 expression and indirectly increased expression of CCR7, L-selectin and Transforming growth factor-beta1 (TGF-beta1) at the late phase of CD2/CD3/CD28-initiated T cell activation.	Curcumin	19-27	transforming growth factor beta 1	Homo sapiens	142-174
23658623-6	2013	On the other hand, curcumin attenuated the spontaneous decline of CD69 expression and indirectly increased expression of CCR7, L-selectin and Transforming growth factor-beta1 (TGF-beta1) at the late phase of CD2/CD3/CD28-initiated T cell activation.	Curcumin	19-27	transforming growth factor beta 1	Homo sapiens	176-185
23658623-7	2013	Curcumin-mediated up-regulation of CD69 at late phase was associated with ERK1/2 signaling.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	74-80
23658623-8	2013	Furthermore, TGF-beta1 was involved in curcumin-mediated regulation of T cell activation and late-phase generation of regulatory T cells.	Curcumin	39-47	transforming growth factor beta 1	Homo sapiens	13-22
23658623-9	2013	CONCLUSIONS/SIGNIFICANCE: Curcumin not merely blocks, but regulates CD2/CD3/CD28-initiated CD4(+) T cell activation by augmenting CD69, CCR7, L-selectin and TGF-beta1 expression followed by regulatory T cell generation.	Curcumin	26-34	CD4 molecule	Homo sapiens	91-94
23658623-9	2013	CONCLUSIONS/SIGNIFICANCE: Curcumin not merely blocks, but regulates CD2/CD3/CD28-initiated CD4(+) T cell activation by augmenting CD69, CCR7, L-selectin and TGF-beta1 expression followed by regulatory T cell generation.	Curcumin	26-34	C-C motif chemokine receptor 7	Homo sapiens	136-140
23658623-9	2013	CONCLUSIONS/SIGNIFICANCE: Curcumin not merely blocks, but regulates CD2/CD3/CD28-initiated CD4(+) T cell activation by augmenting CD69, CCR7, L-selectin and TGF-beta1 expression followed by regulatory T cell generation.	Curcumin	26-34	transforming growth factor beta 1	Homo sapiens	157-166
23658623-10	2013	These results suggest that curcumin could directly reduce T cell-dependent inflammatory stress by modulating CD4(+) T cell activation at multiple levels.	Curcumin	27-35	CD4 molecule	Homo sapiens	109-112
23480634-0	2013	Mechanistic insights of curcumin interactions with the core-recognition motif of beta-amyloid peptide.	Curcumin	24-32	amyloid beta precursor protein	Homo sapiens	81-101
23364261-0	2013	Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-kappaB regulation.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	144-153
23364261-5	2013	When NF-kappaB activity was blocked by using SN50, an inhibitor of NF-kappaB, or cells treated with curcumin, the repression of Prdx6 expression was restored, suggesting the involvement of NF-kappaB in modulating Prdx6 expression.	Curcumin	100-108	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	5-14
23184090-8	2013	RESULTS: Curcumin dramatically attenuated the progression and severity of CIA in DBA/1 J mice, accompanied with decrease of BAFF production in serum and spleen cells as well as decrease of serum IFNgamma and IL-6.	Curcumin	9-17	interferon gamma	Mus musculus	195-203
23184090-8	2013	RESULTS: Curcumin dramatically attenuated the progression and severity of CIA in DBA/1 J mice, accompanied with decrease of BAFF production in serum and spleen cells as well as decrease of serum IFNgamma and IL-6.	Curcumin	9-17	interleukin 6	Mus musculus	208-212
23184090-9	2013	Treatment of B lymphocytes with curcumin suppressed IFNgamma-induced BAFF expression, STAT1 phosphorylation and nuclear translocation, suggesting that curcumin may repress IFNgamma-induced BAFF expression via negatively interfering with STAT1 signaling.	Curcumin	32-40	interferon gamma	Mus musculus	52-60
23184090-9	2013	Treatment of B lymphocytes with curcumin suppressed IFNgamma-induced BAFF expression, STAT1 phosphorylation and nuclear translocation, suggesting that curcumin may repress IFNgamma-induced BAFF expression via negatively interfering with STAT1 signaling.	Curcumin	32-40	interferon gamma	Mus musculus	172-180
23184090-9	2013	Treatment of B lymphocytes with curcumin suppressed IFNgamma-induced BAFF expression, STAT1 phosphorylation and nuclear translocation, suggesting that curcumin may repress IFNgamma-induced BAFF expression via negatively interfering with STAT1 signaling.	Curcumin	151-159	interferon gamma	Mus musculus	52-60
23184090-9	2013	Treatment of B lymphocytes with curcumin suppressed IFNgamma-induced BAFF expression, STAT1 phosphorylation and nuclear translocation, suggesting that curcumin may repress IFNgamma-induced BAFF expression via negatively interfering with STAT1 signaling.	Curcumin	151-159	interferon gamma	Mus musculus	172-180
23761708-0	2013	Modulation of multidrug resistance 1 expression and function in retinoblastoma cells by curcumin.	Curcumin	88-96	ATP binding cassette subfamily B member 1	Homo sapiens	14-36
23761708-1	2013	OBJECTIVE: To determine the possible interaction of curcumin with P-glycoprotein (P-gp) expression and function by in vitro and in silico studies.	Curcumin	52-60	ATP binding cassette subfamily B member 1	Homo sapiens	66-80
23761708-1	2013	OBJECTIVE: To determine the possible interaction of curcumin with P-glycoprotein (P-gp) expression and function by in vitro and in silico studies.	Curcumin	52-60	ATP binding cassette subfamily B member 1	Homo sapiens	82-86
23761708-2	2013	MATERIALS AND METHODS: In this study, curcumin was compared for its potential to modulate the expression and function of P-gp in Y79 RB cells by western blot, RT-PCR (reverse transcription polymerase chain reaction) and functional assay.	Curcumin	38-46	ATP binding cassette subfamily B member 1	Homo sapiens	121-125
23761708-5	2013	The effect of curcumin on P-gp function was demonstrated by Rhodamine 123 (Rh123) accumulation and efflux study.	Curcumin	14-22	ATP binding cassette subfamily B member 1	Homo sapiens	26-30
23761708-8	2013	Moreover, molecular docking studies concurrently infer the binding of curcumin into the substrate binding site of P-gp with a binding energy of -7.66 kcal/mol.	Curcumin	70-78	ATP binding cassette subfamily B member 1	Homo sapiens	114-118
23761708-9	2013	CONCLUSION: These findings indicate that curcumin suppresses the MDR1 expression and function, and therefore may be useful as modulators of multidrug resistance in RB tumor.	Curcumin	41-49	ATP binding cassette subfamily B member 1	Homo sapiens	65-69
22476324-4	2013	The increased activity of SOD and translated products of SOD1 and SOD2 in cerebral cortex of T4-treated rats was ameliorated on supplementation of curcumin.	Curcumin	147-155	superoxide dismutase 1	Rattus norvegicus	57-61
23511143-13	2013	CONCLUSION: These data suggest that leptin and Ob-Rb-dependent ERK and p38 MAPK signaling pathways may be involved in curcumin protection against intestinal I/R injury, and leptin may be a potential target of curcumin in intestinal I/R injury and other related acute diseases.	Curcumin	118-126	mitogen-activated protein kinase 1	Mus musculus	63-66
23511143-13	2013	CONCLUSION: These data suggest that leptin and Ob-Rb-dependent ERK and p38 MAPK signaling pathways may be involved in curcumin protection against intestinal I/R injury, and leptin may be a potential target of curcumin in intestinal I/R injury and other related acute diseases.	Curcumin	118-126	mitogen-activated protein kinase 1	Mus musculus	75-79
23511143-13	2013	CONCLUSION: These data suggest that leptin and Ob-Rb-dependent ERK and p38 MAPK signaling pathways may be involved in curcumin protection against intestinal I/R injury, and leptin may be a potential target of curcumin in intestinal I/R injury and other related acute diseases.	Curcumin	209-217	mitogen-activated protein kinase 1	Mus musculus	63-66
22476324-5	2013	The decreased activity of SOD and protein expression of SOD1 in cerebellum of T4-treated rats were ameliorated on administration of curcumin.	Curcumin	132-140	superoxide dismutase 1	Rattus norvegicus	56-60
23352975-0	2013	Curcumin induces FasL-related apoptosis through p38 activation in human hepatocellular carcinoma Huh7 cells.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	48-51
23402943-9	2013	50mg/kg curcumin administration significantly ameliorated the hippocampal SOD activity, and increased the intensity of p-CaMKII in the stratum lucidum of hippocampal CA3 and p-NMDAR1 expression in the hippocampal membrane fraction of the SAMP8 mice.	Curcumin	8-16	carbonic anhydrase 3	Mus musculus	166-169
26105926-15	2013	IL-8 was inhibited up to 67% by the liposomal curcumin in human vaginal cell lines (End1/E6E7, Ect1/E6E7, VK2/E6E7) as compared to curcumin.	Curcumin	46-54	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23335797-4	2013	Treatment groups received a single dose of the peroxynitrite decomposition catalyst 5,10,15,20-tetrakis(4-sulfonatophenyl)prophyrinato iron (III), the nonspecific NF-kappaB inhibitor curcumin, or the broad-spectrum MMP inhibitor minocycline at reperfusion.	Curcumin	183-191	nuclear factor kappa B subunit 1	Homo sapiens	163-172
23352975-9	2013	SIGNIFICANCE: Our results demonstrated that curcumin induces apoptosis through p38-denpendent up-regulation of FasL in Huh7 cells.	Curcumin	44-52	mitogen-activated protein kinase 14	Homo sapiens	79-82
23352975-5	2013	KEY FINDINGS: Curcumin treatment resulted in a fast and significant increase of Fas and Fas ligand (FasL) along with activation of caspase-3 and cleavage of PARP in Huh7 cells.	Curcumin	14-22	caspase 3	Homo sapiens	131-140
23352975-6	2013	Inhibition of caspase-3 activity by the specific inhibitor Z-DEVD-FMK rescued Huh7 cells from curcumin-induced apoptosis.	Curcumin	94-102	caspase 3	Homo sapiens	14-23
23352975-7	2013	Neutralization of FasL significantly protected the cells from curcumin-induced caspase-3 activation and apoptosis in a dose-dependent manner.	Curcumin	62-70	caspase 3	Homo sapiens	79-88
23352975-8	2013	Moreover, p38 was rapidly activated in response to curcumin, and inactivation of p38 by pharmacologic inhibitor SB203580 dramatically suppressed curcumin-induced FasL expression and apoptosis.	Curcumin	51-59	mitogen-activated protein kinase 14	Homo sapiens	10-13
23352975-8	2013	Moreover, p38 was rapidly activated in response to curcumin, and inactivation of p38 by pharmacologic inhibitor SB203580 dramatically suppressed curcumin-induced FasL expression and apoptosis.	Curcumin	145-153	mitogen-activated protein kinase 14	Homo sapiens	10-13
23352975-8	2013	Moreover, p38 was rapidly activated in response to curcumin, and inactivation of p38 by pharmacologic inhibitor SB203580 dramatically suppressed curcumin-induced FasL expression and apoptosis.	Curcumin	145-153	mitogen-activated protein kinase 14	Homo sapiens	81-84
23414105-6	2013	Curcumin as a model drug was encapsulated successfully into FA-SPI nanoparticles, evidenced by X-ray diffraction study.	Curcumin	0-8	chromogranin A	Homo sapiens	63-66
23261315-7	2013	Pretreatment of cells with the classical and novel PKC antagonists GF109203X and calphostin C completely abolished curcumin-induced IBa inhibition, whereas the classical PKC antagonist Go6976 or inhibition of PKA activity elicited no such effects.	Curcumin	115-123	protein kinase C, epsilon	Rattus norvegicus	51-54
23414105-8	2013	In addition, a faster and more complete release of curcumin was observed for FA-SPI nanoparticles in PBS/Tween 20 buffer.	Curcumin	51-59	chromogranin A	Homo sapiens	80-83
23219912-0	2013	Curcumin attenuates endothelial cell oxidative stress injury through Notch signaling inhibition.	Curcumin	0-8	notch receptor 1	Homo sapiens	69-74
23219912-9	2013	The protective effects of curcumin against OSI are at least in part dependent on Notch1 inhibition.	Curcumin	26-34	notch receptor 1	Homo sapiens	81-87
23415873-7	2013	Furthermore, curcumin increased the expression of the ER stress associated transcriptional factors XBP-1, cleaved p50ATF6alpha and C/EBP homologous protein (CHOP) in human CD4+ and Jurkat T cells.	Curcumin	13-21	DNA damage inducible transcript 3	Homo sapiens	157-161
23222814-6	2013	However, simultaneous exposure to BPA and the polyphenol, curcumin, partially or fully reduced the spectrum of effects associated with BPA alone, including mTOR pathway proteins (AKT1, RPS6, pRPS6 and 4EBP1).	Curcumin	58-66	mechanistic target of rapamycin kinase	Homo sapiens	156-160
23222814-6	2013	However, simultaneous exposure to BPA and the polyphenol, curcumin, partially or fully reduced the spectrum of effects associated with BPA alone, including mTOR pathway proteins (AKT1, RPS6, pRPS6 and 4EBP1).	Curcumin	58-66	AKT serine/threonine kinase 1	Homo sapiens	179-183
23506591-0	2013	Curcumin exerts antinociceptive effects by inhibiting the activation of astrocytes in spinal dorsal horn and the intracellular extracellular signal-regulated kinase signaling pathway in rat model of chronic constriction injury.	Curcumin	0-8	Eph receptor B1	Rattus norvegicus	127-164
23506591-4	2013	This study investigated the effects of tolerable doses of curcumin on the activation of astrocytes and ERK signaling in the spinal dorsal horn in rat model of neuropathic pain.	Curcumin	58-66	Eph receptor B1	Rattus norvegicus	103-106
23506591-13	2013	Curcumin reduced the injury-induced thermal and mechanical hyperalgesia, the increase in the fluorescence intensity of GFAP and the hypertrophy of astrocytic soma, activation of GFAP and phosphorylation of ERK in the spinal dorsal horn.	Curcumin	0-8	Eph receptor B1	Rattus norvegicus	206-209
23506591-15	2013	The analgesic effect of curcumin may be attributed to its inhibition of astrocyte hypertrophy in the spinal dorsal horn and phosphorylation of the ERK signaling pathway.	Curcumin	24-32	Eph receptor B1	Rattus norvegicus	147-150
23415873-0	2013	Curcumin induces apoptotic cell death of activated human CD4+ T cells via increasing endoplasmic reticulum stress and mitochondrial dysfunction.	Curcumin	0-8	CD4 molecule	Homo sapiens	57-60
23415873-4	2013	We studied the potential of curcumin to modulate CD4+ T cells-mediated autoimmune disease, by examining the effects of this compound on human CD4+ lymphocyte activation.	Curcumin	28-36	CD4 molecule	Homo sapiens	49-52
23415873-7	2013	Furthermore, curcumin increased the expression of the ER stress associated transcriptional factors XBP-1, cleaved p50ATF6alpha and C/EBP homologous protein (CHOP) in human CD4+ and Jurkat T cells.	Curcumin	13-21	DNA damage inducible transcript 3	Homo sapiens	131-155
23219912-7	2013	Immunofluorescence and Western blotting analyses demonstrated that H(2)O(2) treatment upregulated the expression of Notch1, Hes1, Caspase3, Bax and cytochrome c downregulated the expression of Bcl2, and treatment with curcumin reversed these effects.	Curcumin	218-226	notch receptor 1	Homo sapiens	116-122
23219912-7	2013	Immunofluorescence and Western blotting analyses demonstrated that H(2)O(2) treatment upregulated the expression of Notch1, Hes1, Caspase3, Bax and cytochrome c downregulated the expression of Bcl2, and treatment with curcumin reversed these effects.	Curcumin	218-226	caspase 3	Homo sapiens	130-138
23219912-7	2013	Immunofluorescence and Western blotting analyses demonstrated that H(2)O(2) treatment upregulated the expression of Notch1, Hes1, Caspase3, Bax and cytochrome c downregulated the expression of Bcl2, and treatment with curcumin reversed these effects.	Curcumin	218-226	BCL2 associated X, apoptosis regulator	Homo sapiens	140-143
23219912-7	2013	Immunofluorescence and Western blotting analyses demonstrated that H(2)O(2) treatment upregulated the expression of Notch1, Hes1, Caspase3, Bax and cytochrome c downregulated the expression of Bcl2, and treatment with curcumin reversed these effects.	Curcumin	218-226	cytochrome c, somatic	Homo sapiens	148-160
23415873-7	2013	Furthermore, curcumin increased the expression of the ER stress associated transcriptional factors XBP-1, cleaved p50ATF6alpha and C/EBP homologous protein (CHOP) in human CD4+ and Jurkat T cells.	Curcumin	13-21	CD4 molecule	Homo sapiens	172-175
23415873-8	2013	In PHA-activated T cells, curcumin further enhanced PHA-induced CHOP expression and reduced the expression of the anti-apoptotic protein Bcl-2.	Curcumin	26-34	DNA damage inducible transcript 3	Homo sapiens	64-68
23415873-8	2013	In PHA-activated T cells, curcumin further enhanced PHA-induced CHOP expression and reduced the expression of the anti-apoptotic protein Bcl-2.	Curcumin	26-34	BCL2 apoptosis regulator	Homo sapiens	137-142
23415873-9	2013	Finally, curcumin treatment induced apoptotic cell death in activated T cells via eliciting an excessive ER stress response, which was reversed by the ER-stress inhibitor 4-phenylbutyric acid or transfection with CHOP-specific siRNA.	Curcumin	9-17	DNA damage inducible transcript 3	Homo sapiens	213-217
23325107-0	2013	Curcumin ameliorates the neurodegenerative pathology in A53T alpha-synuclein cell model of Parkinson"s disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	141-145
23325107-5	2013	We further found that curcumin, a natural compound derived from the curry spice turmeric and with low toxicity in normal cells, could efficiently reduce the accumulation of A53T alpha-synuclein through downregulation of the mTOR/p70S6K signaling and recovery of macroautophagy which was suppressed.	Curcumin	22-30	mechanistic target of rapamycin kinase	Homo sapiens	224-228
23203159-9	2013	Dietary bael (Aegle marmelos) extract (4%) and curcumin (4%) restored Notch and NF-kappaB cross talk in NIH Swiss mice, inhibited CR/DBZ-induced apoptosis in the crypts, and promoted crypt regeneration.	Curcumin	47-55	nuclear factor kappa B subunit 1	Homo sapiens	80-89
22628241-5	2013	Moreover, treatment with 0-30 microg/mL curcumin decreased the mitochondrial membrane potential and activated the caspase-3 and caspase-9 in a dose- and time-dependent manner.	Curcumin	40-48	caspase 3	Homo sapiens	114-123
22628241-8	2013	Furthermore, western blotting analysis indicated that curcumin induced the release of cytochrome c, a significant increase of Bax and p53 and a marked reduction of Bcl-2 and survivin in LoVo cells.	Curcumin	54-62	cytochrome c, somatic	Homo sapiens	86-98
22628241-8	2013	Furthermore, western blotting analysis indicated that curcumin induced the release of cytochrome c, a significant increase of Bax and p53 and a marked reduction of Bcl-2 and survivin in LoVo cells.	Curcumin	54-62	BCL2 associated X, apoptosis regulator	Homo sapiens	126-129
22628241-8	2013	Furthermore, western blotting analysis indicated that curcumin induced the release of cytochrome c, a significant increase of Bax and p53 and a marked reduction of Bcl-2 and survivin in LoVo cells.	Curcumin	54-62	tumor protein p53	Homo sapiens	134-137
22628241-8	2013	Furthermore, western blotting analysis indicated that curcumin induced the release of cytochrome c, a significant increase of Bax and p53 and a marked reduction of Bcl-2 and survivin in LoVo cells.	Curcumin	54-62	BCL2 apoptosis regulator	Homo sapiens	164-169
23264626-10	2013	Instead curcumin differentially impacted HSP90 client kinases, reducing Fyn without reducing Akt.	Curcumin	8-16	thymoma viral proto-oncogene 1	Mus musculus	93-96
23294827-3	2013	Hsp70 contributes to an escape from the apoptotic effects of curcumin by several different mechanisms including prevention of the release of apoptosis inducing factor from the mitochondria and inhibition of caspases 3 and 9.	Curcumin	61-69	caspase 3	Homo sapiens	207-223
23294827-7	2013	Peptides pulled down from this reaction were sequenced and it was determined that biotinylated curcumin bound hsp70, hsp90, 3-phosphoglycerate dehydrogenase, and a beta-actin variant.	Curcumin	95-103	amyloid beta precursor protein	Homo sapiens	162-168
23271001-5	2013	Curcumin was able (a) to reverse 5/6NX-induced glomerular hypertension and hyperfiltration, (b) to induce cell proliferation and nuclear translocation of Nrf2 and (c) to reverse 5/6NX-induced oxidant stress and decrease in antioxidant enzymes.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	154-158
23125222-5	2013	Flow cytometry confirmed that these lines underwent G(2)/M arrest following treatment for 12h with clinically relevant concentrations of curcumin (5-10 muM).	Curcumin	137-145	latexin	Homo sapiens	152-155
23581983-7	2013	Widely known natural Keap1-Nrf2 activators include curcumin, quercetin, resveratrol, and sulforaphane.	Curcumin	51-59	kelch like ECH associated protein 1	Homo sapiens	21-26
23581983-7	2013	Widely known natural Keap1-Nrf2 activators include curcumin, quercetin, resveratrol, and sulforaphane.	Curcumin	51-59	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
23108037-9	2013	In addition, we observed an increase of fibrinogen adsorption to PLGA-films containing curcumin.	Curcumin	87-95	fibrinogen beta chain	Homo sapiens	40-50
23347846-8	2013	RESULTS: Curcumin effectively blocked IL-1beta and PMA-induced IL-6 expression both in MH7A cells and RA-FLS.	Curcumin	9-17	interleukin 1 beta	Homo sapiens	38-46
23347846-8	2013	RESULTS: Curcumin effectively blocked IL-1beta and PMA-induced IL-6 expression both in MH7A cells and RA-FLS.	Curcumin	9-17	interleukin 6	Homo sapiens	63-67
23347846-10	2013	Furthermore, curcumin inhibited activation of NF-kappaB and induced dephosphorylation of ERK1/2.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	46-55
23347846-10	2013	Furthermore, curcumin inhibited activation of NF-kappaB and induced dephosphorylation of ERK1/2.	Curcumin	13-21	mitogen-activated protein kinase 3	Homo sapiens	89-95
23116244-12	2013	RESULTS: Expression of Bcl-2 was significantly increased in the curcumin + dexamethasone group compared with dexamethasone-treated animals (p &lt; 0.05).	Curcumin	64-72	B cell leukemia/lymphoma 2	Mus musculus	23-28
23116244-15	2013	DISCUSSION AND CONCLUSION: The results of this study demonstrate that curcumin increases the expression of Bcl-2 protein, an important anti-apoptotic factor, and improves the spermatogenesis defects in dexamethasone treated mice.	Curcumin	70-78	B cell leukemia/lymphoma 2	Mus musculus	107-112
22948514-7	2013	In addition, curcumin inhibited intrahepatic expression of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 protein.	Curcumin	13-21	tumor necrosis factor	Mus musculus	59-86
22948514-7	2013	In addition, curcumin inhibited intrahepatic expression of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 protein.	Curcumin	13-21	tumor necrosis factor	Mus musculus	88-97
22948514-7	2013	In addition, curcumin inhibited intrahepatic expression of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 protein.	Curcumin	13-21	interleukin 1 beta	Mus musculus	100-122
22948514-7	2013	In addition, curcumin inhibited intrahepatic expression of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 protein.	Curcumin	13-21	interleukin 6	Mus musculus	127-131
23356739-0	2013	Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells.	Curcumin	37-45	tumor protein p53	Homo sapiens	61-64
23356739-4	2013	In this study we assessed the effects of the phytocompounds garcinol and curcumin on histone and p53 modification in cancer cells, focussing on the breast tumour cell line MCF7.	Curcumin	73-81	tumor protein p53	Homo sapiens	97-100
23353121-2	2013	The cytotoxic effects of these compounds along with the lead compound curcumin (7) and their effect on the production of the reactive oxygen species nitric oxide and pro-inflammatory cytokines IL-1beta, TNF-alpha and chemokine CXCL-8 were evaluated using human monocytic THP-1 and colon adenocarcinoma CACO-2 cell lines.	Curcumin	70-78	interleukin 1 beta	Homo sapiens	193-201
23353121-2	2013	The cytotoxic effects of these compounds along with the lead compound curcumin (7) and their effect on the production of the reactive oxygen species nitric oxide and pro-inflammatory cytokines IL-1beta, TNF-alpha and chemokine CXCL-8 were evaluated using human monocytic THP-1 and colon adenocarcinoma CACO-2 cell lines.	Curcumin	70-78	tumor necrosis factor	Homo sapiens	203-212
23245570-0	2013	Design, synthesis and molecular docking of alpha,beta-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferative activity.	Curcumin	93-101	epidermal growth factor receptor	Homo sapiens	112-116
23245570-1	2013	A type of novel alpha,beta-unsaturated cyclohexanone analogous, which designed based on the curcumin core structure, have been discovered as potential EGFR inhibitors.	Curcumin	92-100	epidermal growth factor receptor	Homo sapiens	151-155
23299550-8	2013	In our cell models, curcumin could suppress expression of pro-growth and anti-apoptosis molecules, induce inactivation of NF-kappaB, Src and Akt/mTOR pathways and downregulate the key epigenetic modifier EZH2.	Curcumin	20-28	nuclear factor kappa B subunit 1	Homo sapiens	122-131
23079231-5	2013	Influence of curcumin on interleukin-2 (IL-2) release and IkappaB-phosphorylation in PBMC was determined by ELISA and western blot, respectively.	Curcumin	13-21	interleukin 2	Homo sapiens	25-38
23299550-8	2013	In our cell models, curcumin could suppress expression of pro-growth and anti-apoptosis molecules, induce inactivation of NF-kappaB, Src and Akt/mTOR pathways and downregulate the key epigenetic modifier EZH2.	Curcumin	20-28	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	133-136
23299550-8	2013	In our cell models, curcumin could suppress expression of pro-growth and anti-apoptosis molecules, induce inactivation of NF-kappaB, Src and Akt/mTOR pathways and downregulate the key epigenetic modifier EZH2.	Curcumin	20-28	AKT serine/threonine kinase 1	Homo sapiens	141-144
23299550-8	2013	In our cell models, curcumin could suppress expression of pro-growth and anti-apoptosis molecules, induce inactivation of NF-kappaB, Src and Akt/mTOR pathways and downregulate the key epigenetic modifier EZH2.	Curcumin	20-28	mechanistic target of rapamycin kinase	Homo sapiens	145-149
23299550-8	2013	In our cell models, curcumin could suppress expression of pro-growth and anti-apoptosis molecules, induce inactivation of NF-kappaB, Src and Akt/mTOR pathways and downregulate the key epigenetic modifier EZH2.	Curcumin	20-28	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	204-208
24083709-0	2013	Curcumin inhibits human non-small cell lung cancer A549 cell proliferation through regulation of Bcl-2/Bax and cytochrome C.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	97-102
24381587-7	2013	Curcumin administration in methotrexate-intoxicated rats resulted in nephroprotective effects as evidenced by the significant decrease in levels of serum creatinine and urea as well as renal malondialdehyde, nitric oxide, and tumor necrosis factor- alpha with a concurrent increase in renal glutathione peroxidase and superoxide dismutase activities compared to nephrotoxic untreated rats.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	226-254
24117066-8	2013	Meanwhile, the expression of LXR-beta, RXR-alpha, ABCA1 and apoA-I mRNA and protein were increased in a dose-dependent manner after curcumin treatment.	Curcumin	132-140	retinoid X receptor alpha	Rattus norvegicus	39-48
24117066-10	2013	We conclude that curcumin has the ability to activate permissive LXR-beta/RXR-alpha signaling and thereby modulate ABCA1 and apoA-I-mediated cholesterol transmembrane transportation, which is a new preventive and therapeutic strategy for cerevascular diseases.	Curcumin	17-25	retinoid X receptor alpha	Rattus norvegicus	74-83
22729592-6	2013	Curcumin supplementation increased plasma concentrations of angiogenic factors angiogenin (p &lt; 0.05), basic fibroblast growth factor (p &lt; 0.05) and vascular endothelial growth factor (p &lt; 0.05), as well as inflammatory cytokines interleukin-1beta (p &lt; 0.05) and monocyte chemotactic protein-1 (p &lt; 0.05), compared to the controls.	Curcumin	0-8	interleukin 1 beta	Mus musculus	238-255
23143785-6	2013	Curcumin"s pleiotropic activities emanate from its ability to modulate numerous signaling molecules such as pro-inflammatory cytokines, apoptotic proteins, NF-kappaB, cyclooxygenase-2, 5-LOX, STAT3, C-reactive protein, prostaglandin E(2), prostate-specific antigen, adhesion molecules, phosphorylase kinase, transforming growth factor-beta, triglyceride, ET-1, creatinine, HO-1, AST, and ALT in human participants.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	192-197
23143785-6	2013	Curcumin"s pleiotropic activities emanate from its ability to modulate numerous signaling molecules such as pro-inflammatory cytokines, apoptotic proteins, NF-kappaB, cyclooxygenase-2, 5-LOX, STAT3, C-reactive protein, prostaglandin E(2), prostate-specific antigen, adhesion molecules, phosphorylase kinase, transforming growth factor-beta, triglyceride, ET-1, creatinine, HO-1, AST, and ALT in human participants.	Curcumin	0-8	C-reactive protein	Homo sapiens	199-217
23143785-6	2013	Curcumin"s pleiotropic activities emanate from its ability to modulate numerous signaling molecules such as pro-inflammatory cytokines, apoptotic proteins, NF-kappaB, cyclooxygenase-2, 5-LOX, STAT3, C-reactive protein, prostaglandin E(2), prostate-specific antigen, adhesion molecules, phosphorylase kinase, transforming growth factor-beta, triglyceride, ET-1, creatinine, HO-1, AST, and ALT in human participants.	Curcumin	0-8	endothelin 1	Homo sapiens	355-377
23143785-6	2013	Curcumin"s pleiotropic activities emanate from its ability to modulate numerous signaling molecules such as pro-inflammatory cytokines, apoptotic proteins, NF-kappaB, cyclooxygenase-2, 5-LOX, STAT3, C-reactive protein, prostaglandin E(2), prostate-specific antigen, adhesion molecules, phosphorylase kinase, transforming growth factor-beta, triglyceride, ET-1, creatinine, HO-1, AST, and ALT in human participants.	Curcumin	0-8	solute carrier family 17 member 5	Homo sapiens	379-382
24083709-0	2013	Curcumin inhibits human non-small cell lung cancer A549 cell proliferation through regulation of Bcl-2/Bax and cytochrome C.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	103-106
24083709-0	2013	Curcumin inhibits human non-small cell lung cancer A549 cell proliferation through regulation of Bcl-2/Bax and cytochrome C.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	111-123
24083709-3	2013	And to further confirm the relative anti-cancer mechanism of curcumin, RT-PCR was carried out to analysis the expression of relative apoptotic proteins Bax, Bcl-2.	Curcumin	61-69	BCL2 associated X, apoptosis regulator	Homo sapiens	152-155
24083709-3	2013	And to further confirm the relative anti-cancer mechanism of curcumin, RT-PCR was carried out to analysis the expression of relative apoptotic proteins Bax, Bcl-2.	Curcumin	61-69	BCL2 apoptosis regulator	Homo sapiens	157-162
24083709-4	2013	We found that curcumin could up-regulate the expression of Bax but down-regulate the expression of Bcl-2 in A549 cells.	Curcumin	14-22	BCL2 associated X, apoptosis regulator	Homo sapiens	59-62
23303639-5	2013	The effects of curcumin on NF-kappabeta are crucial to our understanding of the potent hepatoprotective role of this herb-derived micronutrient.	Curcumin	15-23	nuclear factor kappa B subunit 1	Homo sapiens	27-39
24083709-4	2013	We found that curcumin could up-regulate the expression of Bax but down-regulate the expression of Bcl-2 in A549 cells.	Curcumin	14-22	BCL2 apoptosis regulator	Homo sapiens	99-104
24083709-6	2013	These results suggested that curcumin inhibited cancer cell growth through the regulation of Bcl-2/Bax and affect the mitochondrial apoptosis pathway.	Curcumin	29-37	BCL2 apoptosis regulator	Homo sapiens	93-98
23325575-7	2013	Curcumin up-regulated expression of SOD genes and down-regulated expression of several age-related genes, such as dInR, ATTD, Def, CecB, and DptB.	Curcumin	0-8	Defensin	Drosophila melanogaster	126-129
24083709-6	2013	These results suggested that curcumin inhibited cancer cell growth through the regulation of Bcl-2/Bax and affect the mitochondrial apoptosis pathway.	Curcumin	29-37	BCL2 associated X, apoptosis regulator	Homo sapiens	99-102
23085457-3	2013	TRAIL-induced activation of Akt catalytic activity and phosphorylation were highly correlated with p38/HSP27 phosphorylation, whereas the phosphorylation of p38/HSP27 increased further during incubation with curcumin and TRAIL, which caused significant apoptotic cell death.	Curcumin	208-216	mitogen-activated protein kinase 14	Homo sapiens	157-160
23936796-2	2013	In this study, purified PMPMEase was inhibited by the chemopreventive agent, curcumin, with a K(i) of 0.3 muM (IC50 = 12.4 muM).	Curcumin	77-85	latexin	Homo sapiens	106-109
23936796-2	2013	In this study, purified PMPMEase was inhibited by the chemopreventive agent, curcumin, with a K(i) of 0.3 muM (IC50 = 12.4 muM).	Curcumin	77-85	latexin	Homo sapiens	123-126
23936796-4	2013	Kinetics analysis with N-para-nitrobenzoyl-S-trans,trans-farnesylcysteine methyl ester substrate yielded K M values of 23.6 +- 2.7 and 85.3 +- 15.3 muM in the absence or presence of 20 muM curcumin, respectively.	Curcumin	189-197	latexin	Homo sapiens	148-151
23085457-3	2013	TRAIL-induced activation of Akt catalytic activity and phosphorylation were highly correlated with p38/HSP27 phosphorylation, whereas the phosphorylation of p38/HSP27 increased further during incubation with curcumin and TRAIL, which caused significant apoptotic cell death.	Curcumin	208-216	TNF superfamily member 10	Homo sapiens	0-5
23069388-8	2013	Most importantly, immunohistochemistry (IHC) analysis of mice tissues demonstrated that curcumin reduced TTR load in as much as 70% and lowered cytotoxicity associated with TTR aggregation by decreasing activation of death receptor Fas/CD95, endoplasmic reticulum (ER) chaperone BiP and 3-nitrotyrosine in tissues.	Curcumin	88-96	Fas (TNF receptor superfamily member 6)	Mus musculus	236-240
23069388-8	2013	Most importantly, immunohistochemistry (IHC) analysis of mice tissues demonstrated that curcumin reduced TTR load in as much as 70% and lowered cytotoxicity associated with TTR aggregation by decreasing activation of death receptor Fas/CD95, endoplasmic reticulum (ER) chaperone BiP and 3-nitrotyrosine in tissues.	Curcumin	88-96	heat shock protein 5	Mus musculus	279-282
24024180-0	2013	Effect of mesenchymal stem cells and a novel curcumin derivative on Notch1 signaling in hepatoma cell line.	Curcumin	45-53	notch receptor 1	Homo sapiens	68-74
23509769-0	2013	The sonodynamic effect of curcumin on THP-1 cell-derived macrophages.	Curcumin	26-34	GLI family zinc finger 2	Homo sapiens	38-43
23509769-4	2013	THP-1-derived macrophages were incubated with curcumin at a concentration of 40.7  mumol/L for 2 h and then exposed to pulse ultrasound irradiation (2 W/cm(2) with 0.86 MHz) for 5-15 min.	Curcumin	46-54	GLI family zinc finger 2	Homo sapiens	0-5
23509769-8	2013	These findings support that curcumin had sonodynamic effect on THP-1-derived macrophages and that curcumin SDT could be a promising treatment for atherosclerosis.	Curcumin	28-36	GLI family zinc finger 2	Homo sapiens	63-68
23085457-3	2013	TRAIL-induced activation of Akt catalytic activity and phosphorylation were highly correlated with p38/HSP27 phosphorylation, whereas the phosphorylation of p38/HSP27 increased further during incubation with curcumin and TRAIL, which caused significant apoptotic cell death.	Curcumin	208-216	AKT serine/threonine kinase 1	Homo sapiens	28-31
23085457-3	2013	TRAIL-induced activation of Akt catalytic activity and phosphorylation were highly correlated with p38/HSP27 phosphorylation, whereas the phosphorylation of p38/HSP27 increased further during incubation with curcumin and TRAIL, which caused significant apoptotic cell death.	Curcumin	208-216	TNF superfamily member 10	Homo sapiens	221-226
23085457-6	2013	However, further increases in p38/HSP27 phosphorylation induced by cotreatment with curcumin and TRAIL converted cell fate to death.	Curcumin	84-92	mitogen-activated protein kinase 14	Homo sapiens	30-33
23985704-8	2013	Mechanistic studies indicate that the effects of both curcumin and PFBr4 on PC-3 cells were associated with a decrease in phospho-Akt and phospho-extracellular signal-regulated kinase (Erk)1/2.	Curcumin	54-62	mitogen-activated protein kinase 3	Homo sapiens	146-192
24335167-0	2013	Dietary curcumin ameliorates aging-related cerebrovascular dysfunction through the AMPK/uncoupling protein 2 pathway.	Curcumin	8-16	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	83-87
24335167-11	2013	In cerebral arteries from aging SD rats and cultured endothelial cells, curcumin promoted eNOS and AMPK phosphorylation, up-regulated UCP2 and reduced ROS production.	Curcumin	72-80	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	99-103
24335167-12	2013	These effects of curcumin were abolished by either AMPK or UCP2 inhibition.	Curcumin	17-25	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	51-55
24335167-14	2013	CONCLUSIONS: Curcumin improves aging-related cerebrovascular dysfunction via the AMPK/UCP2 pathway.	Curcumin	13-21	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	81-85
23970932-0	2013	Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer.	Curcumin	0-8	cadherin 1	Homo sapiens	61-71
23762140-6	2013	In addition, curcumin suppressed neuroinflammatory response by decreasing inflammatory mediators, such as IL-1 beta , TNF- alpha , PGE2, NO, COX-2, and iNOS induced by cerebral ischemia of rats.	Curcumin	13-21	interleukin 1 beta	Rattus norvegicus	106-115
23762140-6	2013	In addition, curcumin suppressed neuroinflammatory response by decreasing inflammatory mediators, such as IL-1 beta , TNF- alpha , PGE2, NO, COX-2, and iNOS induced by cerebral ischemia of rats.	Curcumin	13-21	tumor necrosis factor	Rattus norvegicus	118-128
23762140-6	2013	In addition, curcumin suppressed neuroinflammatory response by decreasing inflammatory mediators, such as IL-1 beta , TNF- alpha , PGE2, NO, COX-2, and iNOS induced by cerebral ischemia of rats.	Curcumin	13-21	nitric oxide synthase 2	Rattus norvegicus	152-156
23970932-6	2013	We found that curcumin suppresses Sp-1 transcriptional activity and Sp-1 regulated genes including ADEM10, calmodulin, EPHB2, HDAC4, and SEPP1 in CRC cells.	Curcumin	14-22	calmodulin 1	Homo sapiens	107-117
23970932-6	2013	We found that curcumin suppresses Sp-1 transcriptional activity and Sp-1 regulated genes including ADEM10, calmodulin, EPHB2, HDAC4, and SEPP1 in CRC cells.	Curcumin	14-22	selenoprotein P	Homo sapiens	137-142
23970932-8	2013	Curcumin reduces CD24 expression in a dose-dependent manner in CRC cells.	Curcumin	0-8	CD24 molecule	Homo sapiens	17-21
23970932-9	2013	Moreover, E-cadherin expression is upregulated by curcumin and serves as an inhibitor of EMT.	Curcumin	50-58	cadherin 1	Homo sapiens	10-20
23970932-10	2013	These results suggest that curcumin executes its antimetastasis function through downregulation of Sp-1, FAK, and CD24 and by promoting E-cadherin expression in CRC cells.	Curcumin	27-35	CD24 molecule	Homo sapiens	114-118
23970932-10	2013	These results suggest that curcumin executes its antimetastasis function through downregulation of Sp-1, FAK, and CD24 and by promoting E-cadherin expression in CRC cells.	Curcumin	27-35	cadherin 1	Homo sapiens	136-146
23124098-0	2013	Heme oxygenase-1-mediated reactive oxygen species reduction is involved in the inhibitory effect of curcumin on lipopolysaccharide-induced monocyte chemoattractant protein-1 production in RAW264.7 macrophages.	Curcumin	100-108	heme oxygenase 1	Mus musculus	0-16
23471081-0	2013	Curcumin attenuates diabetic neuropathic pain by downregulating TNF-alpha in a rat model.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	64-73
23471081-9	2013	Curcumin significantly attenuated the diabetes-induced allodynia and hyperalgesia and reduced the expression of both TNF-alpha and TNF-alpha receptor 1.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	117-126
23471081-9	2013	Curcumin significantly attenuated the diabetes-induced allodynia and hyperalgesia and reduced the expression of both TNF-alpha and TNF-alpha receptor 1.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	131-140
23471081-10	2013	Curcumin seems to relieve diabetic hyperalgesia, possibly through an inhibitory action on TNF-alpha and TNF-alpha receptor 1.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	90-99
23471081-10	2013	Curcumin seems to relieve diabetic hyperalgesia, possibly through an inhibitory action on TNF-alpha and TNF-alpha receptor 1.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	104-113
23305490-7	2013	The K2P channel blockers methanandamide, lidocaine, zinc and curcumin had antiproliferative effects (P &lt; 0.01) in an endometrial epithelial cancer cell line indicating a role for TASK and TREK-1 channels in proliferation.	Curcumin	61-69	potassium two pore domain channel subfamily K member 2	Homo sapiens	191-197
23526055-2	2013	Given that curcumin can desensitize transient receptor potential A1, a nociceptor seemingly also mediating the analgesic effect of acetaminophen, as well as inhibiting and downregulating the expression of cyclo-oxygenase 2, the selective target of nimesulide, a nonsteroidal anti-inflammatory agent, we carried out a pilot comparative study of the acute pain-relieving properties of these three agents.	Curcumin	11-19	prostaglandin-endoperoxide synthase 2	Homo sapiens	205-222
22704781-0	2013	RETRACTED: Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity.	Curcumin	11-19	NFE2 like bZIP transcription factor 2	Rattus norvegicus	29-33
22704781-5	2013	In this work, we investigated the ability of the antioxidant curcumin to induce transcription factor Nrf2 in a neurodegenerative model induced by quinolinic acid in rats.	Curcumin	61-69	NFE2 like bZIP transcription factor 2	Rattus norvegicus	101-105
22704781-10	2013	The protective effects of curcumin were associated to its ability to prevent the quinolinic acid-induced decrease of striatal intra-nuclear Nrf2 levels (30 and 120 min post-lesion), and total superoxide dismutase and glutathione peroxidase activities (1 day post-lesion).	Curcumin	26-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-144
22704781-11	2013	Therefore, results of this study support the concept that neuroprotection induced by curcumin is associated with its ability to activate the Nrf2 cytoprotective pathway and to increase the total superoxide dismutase and glutathione peroxidase activities.	Curcumin	85-93	NFE2 like bZIP transcription factor 2	Rattus norvegicus	141-145
23603894-0	2013	Inhibition of the PI3K/AKT-NF-kappaB pathway with curcumin enhanced radiation-induced apoptosis in human Burkitt"s lymphoma.	Curcumin	50-58	AKT serine/threonine kinase 1	Homo sapiens	23-26
23603894-0	2013	Inhibition of the PI3K/AKT-NF-kappaB pathway with curcumin enhanced radiation-induced apoptosis in human Burkitt"s lymphoma.	Curcumin	50-58	nuclear factor kappa B subunit 1	Homo sapiens	27-36
23603894-2	2013	Curcumin has been shown to inhibit the PI3K/AKT signal transduction pathway in several tumor models.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	44-47
23603894-3	2013	In this study, we found that curcumin inhibits constitutive and radiation-induced expression of the PI3K/AKT pathway and its downstream regulator nuclear factor kappaB (NF-kappaB) in human Burkitt"s lymphoma, a high-grade non-Hodgkin"s lymphoma (NHL).	Curcumin	29-37	AKT serine/threonine kinase 1	Homo sapiens	105-108
23603894-3	2013	In this study, we found that curcumin inhibits constitutive and radiation-induced expression of the PI3K/AKT pathway and its downstream regulator nuclear factor kappaB (NF-kappaB) in human Burkitt"s lymphoma, a high-grade non-Hodgkin"s lymphoma (NHL).	Curcumin	29-37	nuclear factor kappa B subunit 1	Homo sapiens	169-178
23603894-4	2013	We further demonstrated that the blockage of radiation-induced activation of the PI3K/AKT pathway and its downstream regulator NF-kappaB by either curcumin or specific PI3/AKT inhibitors (LY294002 for PI3K or SH-5 for AKT) enhance apoptosis in three human Burkitt"s lymphoma cell lines (Namalwa, Ramos, and Raji) that were treated with ionizing radiation.	Curcumin	147-155	AKT serine/threonine kinase 1	Homo sapiens	86-89
23603894-4	2013	We further demonstrated that the blockage of radiation-induced activation of the PI3K/AKT pathway and its downstream regulator NF-kappaB by either curcumin or specific PI3/AKT inhibitors (LY294002 for PI3K or SH-5 for AKT) enhance apoptosis in three human Burkitt"s lymphoma cell lines (Namalwa, Ramos, and Raji) that were treated with ionizing radiation.	Curcumin	147-155	nuclear factor kappa B subunit 1	Homo sapiens	127-136
23603894-6	2013	The results from this study suggest that curcumin might play an important role in radiotherapy of high-grade NHL through inhibition of the PI3K/AKT-dependent NF-kappaB pathway.	Curcumin	41-49	AKT serine/threonine kinase 1	Homo sapiens	144-147
23603894-6	2013	The results from this study suggest that curcumin might play an important role in radiotherapy of high-grade NHL through inhibition of the PI3K/AKT-dependent NF-kappaB pathway.	Curcumin	41-49	nuclear factor kappa B subunit 1	Homo sapiens	158-167
24453411-3	2013	Molecular mechanisms of cytokine activities were controlled by NF-kappaB and JAK/STAT signaling pathways, as metabolic inhibitors, curcumin and AG490, inhibited some of TNF-alpha and IFNalpha/IFNgamma effects.	Curcumin	131-139	tumor necrosis factor	Mus musculus	169-178
24453411-3	2013	Molecular mechanisms of cytokine activities were controlled by NF-kappaB and JAK/STAT signaling pathways, as metabolic inhibitors, curcumin and AG490, inhibited some of TNF-alpha and IFNalpha/IFNgamma effects.	Curcumin	131-139	interferon gamma	Mus musculus	192-200
23124098-9	2013	The results presented in our study suggest that curcumin enhances the expression of HO-1 to reduce the LPS-induced production of ROS, which leads to the inhibition of MCP-1 expression in RAW264.7 macrophages.	Curcumin	48-56	heme oxygenase 1	Mus musculus	84-88
23124098-9	2013	The results presented in our study suggest that curcumin enhances the expression of HO-1 to reduce the LPS-induced production of ROS, which leads to the inhibition of MCP-1 expression in RAW264.7 macrophages.	Curcumin	48-56	toll-like receptor 4	Mus musculus	103-106
23559849-13	2013	As determined with quantitative real-time PCR and western blotting, curcumin increased the expression of antioxidant genes and reduced angiotensin II type 1 receptor, nuclear factor-kappa B, and vascular endothelial growth factor expression at the messenger RNA and protein levels.	Curcumin	68-76	vascular endothelial growth factor A	Homo sapiens	195-229
23559849-14	2013	CONCLUSIONS: The results demonstrated that curcumin alters the expression of H2O2-modulated miRNAs that are putative regulators of antioxidant defense and renin-angiotensin systems, which have been reported to be linked to ocular diseases.	Curcumin	43-51	renin	Homo sapiens	155-160
23124098-4	2013	In the current study, we investigated the effect of curcumin on the production of MCP-1 induced by lipopolysaccharide (LPS) in macrophages and the possible mechanisms involved.	Curcumin	52-60	toll-like receptor 4	Mus musculus	119-122
23124098-5	2013	The results revealed that curcumin decreased MCP-1 production in a concentration-dependent manner and reduced the generation of reactive oxygen species (ROS) induced by LPS in RAW264.7 macrophages.	Curcumin	26-34	toll-like receptor 4	Mus musculus	169-172
23124098-6	2013	Additionally, zinc protoporphyrin, a heme oxygenase-1 (HO-1) inhibitor, blocked the inhibitory effect of curcumin on the LPS-induced MCP-1 expression.	Curcumin	105-113	heme oxygenase 1	Mus musculus	37-53
23124098-6	2013	Additionally, zinc protoporphyrin, a heme oxygenase-1 (HO-1) inhibitor, blocked the inhibitory effect of curcumin on the LPS-induced MCP-1 expression.	Curcumin	105-113	heme oxygenase 1	Mus musculus	55-59
23124098-6	2013	Additionally, zinc protoporphyrin, a heme oxygenase-1 (HO-1) inhibitor, blocked the inhibitory effect of curcumin on the LPS-induced MCP-1 expression.	Curcumin	105-113	toll-like receptor 4	Mus musculus	121-124
23124098-7	2013	The exposure of cells to curcumin was found to enhance HO-1 expression.	Curcumin	25-33	heme oxygenase 1	Mus musculus	55-59
23124098-8	2013	Furthermore, additional experiments indicated that the inhibitory effect of curcumin on LPS-induced MCP-1 expression was significantly attenuated in the presence of N-acetylcysteine (an effective ROS scavenger).	Curcumin	76-84	toll-like receptor 4	Mus musculus	88-91
23076367-3	2013	In             this study, we used lipopolysaccharide (LPS) to trigger EMT in MCF-7 and MDA-MB-231             breast cancer cell lines and showed that curcumin inhibited LPS-induced morphological             changes, decreased the expression of LPS-induced markers of EMT such as vimentin,             and increased the expression of E-cadherin, resulting in the inhibition of in vitro             cell motility and invasiveness.	Curcumin	152-160	cadherin 1	Homo sapiens	335-345
23117293-0	2013	Curcumin enhances the response of non-Hodgkin"s lymphoma cells to ionizing             radiation through further induction of cell cycle arrest at the G2/M phase and             inhibition of mTOR phosphorylation.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	192-196
23117293-7	2013	Pre-treatment with curcumin at a low concentration of 2 micromol/l increased IR-induced G2/M arrest in the cell cycle and increased the expression of cyclin-dependent kinase inhibitors, p21cip1 and p53.	Curcumin	19-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	186-193
23117293-7	2013	Pre-treatment with curcumin at a low concentration of 2 micromol/l increased IR-induced G2/M arrest in the cell cycle and increased the expression of cyclin-dependent kinase inhibitors, p21cip1 and p53.	Curcumin	19-27	tumor protein p53	Homo sapiens	198-201
23117293-9	2013	Pre-treatment with curcumin inhibited the phosphorylation of mTOR and the nuclear translocation of the downstream NF-kappaB target induced by IR.	Curcumin	19-27	mechanistic target of rapamycin kinase	Homo sapiens	61-65
23710286-0	2013	Curcumin protects human keratinocytes against inorganic arsenite-induced acute cytotoxicity through an NRF2-dependent mechanism.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	103-107
23117293-10	2013	Curcumin enhanced the cell response to IR in NHL mediated through the induction of G2/M phase arrest and the inhibition of both a constitutive and IR-induced activation of the mTOR-NF-kappaB pathway.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	176-180
24512728-0	2013	Curcumin lowers erlotinib resistance in non-small cell lung carcinoma cells with mutated EGF receptor.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	89-101
24512728-9	2013	Furthermore, curcumin significantly increased the cytotoxicity of erlotinib to erlotinib-resistant NSCLC cells, enhanced erlotinib-induced apoptosis, downregulated the expressions of EGFR, p-EGFR, and survivin, and inhibited the NF-kappaB activation in erlotinib-resistant NSCLC cells.	Curcumin	13-21	epidermal growth factor receptor	Homo sapiens	183-187
24512728-9	2013	Furthermore, curcumin significantly increased the cytotoxicity of erlotinib to erlotinib-resistant NSCLC cells, enhanced erlotinib-induced apoptosis, downregulated the expressions of EGFR, p-EGFR, and survivin, and inhibited the NF-kappaB activation in erlotinib-resistant NSCLC cells.	Curcumin	13-21	epidermal growth factor receptor	Homo sapiens	191-195
23710286-3	2013	The present study aimed at identifying curcumin as a potent activator of nuclear factor erythroid 2-related factor 2 (NRF2) and demonstrating its protective effect against inorganic arsenite- (iAs(3+)-) induced cytotoxicity in human keratinocytes.	Curcumin	39-47	NFE2 like bZIP transcription factor 2	Homo sapiens	73-116
23710286-3	2013	The present study aimed at identifying curcumin as a potent activator of nuclear factor erythroid 2-related factor 2 (NRF2) and demonstrating its protective effect against inorganic arsenite- (iAs(3+)-) induced cytotoxicity in human keratinocytes.	Curcumin	39-47	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
23710286-4	2013	We found that curcumin led to nuclear accumulation of NRF2 protein and increased the expression of antioxidant response element- (ARE-) regulated genes in HaCaT keratinocytes in concentration- and time-dependent manners.	Curcumin	14-22	NFE2 like bZIP transcription factor 2	Homo sapiens	54-58
23710286-5	2013	High concentration of curcumin (20 muM) also increased protein expression of long isoforms of NRF1.	Curcumin	22-30	latexin	Homo sapiens	35-38
23710286-6	2013	Treatment with low concentrations of curcumin (2.5 or 5 muM) effectively increased the viability and survival of HaCaT cells against iAs(3+)-induced cytotoxicity as assessed by the MTT assay and flow cytometry and also attenuated iAs(3+)-induced expression of cleaved caspase-3 and cleaved PARP protein.	Curcumin	37-45	latexin	Homo sapiens	56-59
23710286-7	2013	Selective knockdown of NRF2 or KEAP1 by lentiviral shRNAs significantly diminished the cytoprotection conferred by curcumin, suggesting that the protection against iAs(3+)-induced cytotoxicity is dependent on the activation of NRF2.	Curcumin	115-123	NFE2 like bZIP transcription factor 2	Homo sapiens	23-27
23710286-7	2013	Selective knockdown of NRF2 or KEAP1 by lentiviral shRNAs significantly diminished the cytoprotection conferred by curcumin, suggesting that the protection against iAs(3+)-induced cytotoxicity is dependent on the activation of NRF2.	Curcumin	115-123	kelch like ECH associated protein 1	Homo sapiens	31-36
23710286-7	2013	Selective knockdown of NRF2 or KEAP1 by lentiviral shRNAs significantly diminished the cytoprotection conferred by curcumin, suggesting that the protection against iAs(3+)-induced cytotoxicity is dependent on the activation of NRF2.	Curcumin	115-123	NFE2 like bZIP transcription factor 2	Homo sapiens	227-231
23710286-8	2013	Our results provided a proof of the concept of using curcumin to activate the NRF2 pathway to alleviate arsenic-induced dermal damage.	Curcumin	53-61	NFE2 like bZIP transcription factor 2	Homo sapiens	78-82
23744438-6	2013	RESULTS: The results show that curcumin inhibited the production and mRNA expression of TSLP in HMC-1 cells: the maximal inhibition rate of TSLP production by curcumin (50 muM) was 59.16 +- 4.20%.	Curcumin	31-39	latexin	Homo sapiens	172-175
24454990-0	2013	Curcumin pretreatment induces Nrf2 and an antioxidant response and prevents hemin-induced toxicity in primary cultures of cerebellar granule neurons of rats.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	30-34
24454990-9	2013	Additionally, it was found that curcumin was capable of inducing nuclear factor (erythroid-derived 2)-like 2 (Nrf2) translocation into the nucleus.	Curcumin	32-40	NFE2 like bZIP transcription factor 2	Rattus norvegicus	110-114
24454990-10	2013	These data suggest that the pretreatment with curcumin induces Nrf2 and an antioxidant response that may play an important role in the protective effect of this antioxidant against hemin-induced neuronal death.	Curcumin	46-54	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-67
23744438-6	2013	RESULTS: The results show that curcumin inhibited the production and mRNA expression of TSLP in HMC-1 cells: the maximal inhibition rate of TSLP production by curcumin (50 muM) was 59.16 +- 4.20%.	Curcumin	159-167	latexin	Homo sapiens	172-175
23744438-8	2013	In the activated HMC-1 cells, caspase-1 activity was increased, whereas caspase-1 activity was decreased by pretreatment with curcumin.	Curcumin	126-134	caspase 1	Homo sapiens	72-81
23555722-11	2013	Curcumin reduced the expression and secretion of VEGF under control conditions and abolished the VEGF secretion induced by PDGF and chemical hypoxia.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	49-53
23250811-0	2013	Curcumin improves TNBS-induced colitis in rats by inhibiting IL-27 expression via the TLR4/NF-kappaB signaling pathway.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	86-90
23250811-3	2013	This study explored whether curcumin improves colonic inflammation in a rat colitis model through inhibition of the TLR4/NF-kappaB signaling pathway and IL-27 expression.	Curcumin	28-36	toll-like receptor 4	Rattus norvegicus	116-120
23250811-7	2013	Compared with the untreated colitis group, the curcumin-treated group showed significant decreases in the disease activity index, colonic mucosa damage index, histological score, myeloperoxidase activity, and expressions of NF-kappaB mRNA, IL-27 mRNA, TLR4 protein, NF-kappaB p65 protein, and IL-27 p28 protein (p &lt; 0.05).	Curcumin	47-55	toll-like receptor 4	Rattus norvegicus	252-256
23250811-12	2013	The anti-inflammatory actions of curcumin on colitis may involve inhibition of the TLR4/NF-kappaB signaling pathway and of IL-27 expression.	Curcumin	33-41	toll-like receptor 4	Rattus norvegicus	83-87
23555802-0	2013	Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway.	Curcumin	19-27	AKT serine/threonine kinase 1	Rattus norvegicus	66-69
23555802-0	2013	Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway.	Curcumin	19-27	NFE2 like bZIP transcription factor 2	Rattus norvegicus	70-74
23577194-15	2013	Moreover, the core protein inhibited curcumin-induced apoptosis through p21(Waf1/Cip1)-targeting microRNA-345 in Huh7 cells.	Curcumin	37-45	cyclin dependent kinase inhibitor 1A	Homo sapiens	72-75
23577194-15	2013	Moreover, the core protein inhibited curcumin-induced apoptosis through p21(Waf1/Cip1)-targeting microRNA-345 in Huh7 cells.	Curcumin	37-45	cyclin dependent kinase inhibitor 1A	Homo sapiens	76-80
23577194-15	2013	Moreover, the core protein inhibited curcumin-induced apoptosis through p21(Waf1/Cip1)-targeting microRNA-345 in Huh7 cells.	Curcumin	37-45	cyclin dependent kinase inhibitor 1A	Homo sapiens	81-85
23555802-4	2013	A rapid increase in the intracellular expression of NAD(P)H: quinone oxidoreductase1 (NQO1) induced by OGD was counteracted by curcumin post-treatment, which paralleled attenuated cell injury.	Curcumin	127-135	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	52-84
23555722-11	2013	Curcumin reduced the expression and secretion of VEGF under control conditions and abolished the VEGF secretion induced by PDGF and chemical hypoxia.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	97-101
23555802-4	2013	A rapid increase in the intracellular expression of NAD(P)H: quinone oxidoreductase1 (NQO1) induced by OGD was counteracted by curcumin post-treatment, which paralleled attenuated cell injury.	Curcumin	127-135	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	86-90
23555802-5	2013	The reduction of phosphorylation Akt induced by OGD was restored by curcumin.	Curcumin	68-76	AKT serine/threonine kinase 1	Rattus norvegicus	33-36
23555722-12	2013	Whereas low concentrations of curcumin stimulated the expression of bFGF and HGF, high concentrations caused downregulation of both factors.	Curcumin	30-38	fibroblast growth factor 2	Homo sapiens	68-72
23555802-7	2013	LY294002 blocked the increase in phospho-Akt evoked by curcumin and abolished the associated protective effect.	Curcumin	55-63	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
23555722-14	2013	The cytotoxic effect of curcumin involved activation of caspase-3 and calpain, intracellular calcium signaling, mitochondrial permeability, oxidative stress, increased phosphorylation of p38 MAPK and decreased phosphorylation of Akt protein.	Curcumin	24-32	caspase 3	Homo sapiens	56-65
23555802-11	2013	Taken together, these findings provide evidence that curcumin protects neurons against ischemic injury, and this neuroprotective effect involves the Akt/Nrf2 pathway.	Curcumin	53-61	AKT serine/threonine kinase 1	Rattus norvegicus	149-152
23555802-11	2013	Taken together, these findings provide evidence that curcumin protects neurons against ischemic injury, and this neuroprotective effect involves the Akt/Nrf2 pathway.	Curcumin	53-61	NFE2 like bZIP transcription factor 2	Rattus norvegicus	153-157
23555802-12	2013	In addition, Nrf2 is involved in the neuroprotective effects of curcumin against oxidative damage.	Curcumin	64-72	NFE2 like bZIP transcription factor 2	Rattus norvegicus	13-17
23555722-14	2013	The cytotoxic effect of curcumin involved activation of caspase-3 and calpain, intracellular calcium signaling, mitochondrial permeability, oxidative stress, increased phosphorylation of p38 MAPK and decreased phosphorylation of Akt protein.	Curcumin	24-32	AKT serine/threonine kinase 1	Homo sapiens	229-232
23544048-0	2013	Curcumin inhibits transforming growth factor-beta1-induced EMT via PPARgamma pathway, not Smad pathway in renal tubular epithelial cells.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	67-76
23520547-5	2013	Additionally, treatment of curcumin caused the iron starvation induced expression of FET3, FRE1 genes.	Curcumin	27-35	ferric/cupric-chelate reductase	Saccharomyces cerevisiae S288C	91-95
23544048-8	2013	Further, the effect of curcumin on alpha-SMA, PAI-1, E-cadherin, TbetaR I and TbetaR II were reversed by ERK inhibitor U0126 or PPARgamma inhibitor BADGE, or PPARgamma shRNA.	Curcumin	23-31	cadherin 1	Homo sapiens	53-63
23533564-3	2013	Curcumin and its derivatives as selective inhibitors of 11beta-HSD1 have not been reported.	Curcumin	0-8	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	56-67
23533564-4	2013	METHODOLOGY: Curcumin and its 12 derivatives were tested for their potencies of inhibitory effects on human and rat 11beta-HSD1 with selectivity against 11beta-HSD2.	Curcumin	13-21	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	116-127
23533564-6	2013	RESULTS AND CONCLUSIONS: Curcumin exhibited inhibitory potency against human and rat 11beta-HSD1 in intact cells with IC50 values of 2.29 and 5.79 microM, respectively, with selectivity against 11beta-HSD2 (IC50, 14.56 and 11.92 microM).	Curcumin	25-33	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	85-96
23533564-7	2013	Curcumin was a competitive inhibitor of human and rat 11beta-HSD1.	Curcumin	0-8	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	54-65
23533564-9	2013	Four curcumin derivatives had much higher potencies for Inhibition of 11beta-HSD1.	Curcumin	5-13	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	70-81
23533564-12	2013	In conclusion, curcumin is effective for the treatment of metabolic syndrome and four novel curcumin derivatives had high potencies for inhibition of human 11beta-HSD1 with selectivity against 11beta-HSD2.	Curcumin	15-23	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	156-167
23533564-12	2013	In conclusion, curcumin is effective for the treatment of metabolic syndrome and four novel curcumin derivatives had high potencies for inhibition of human 11beta-HSD1 with selectivity against 11beta-HSD2.	Curcumin	92-100	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	156-167
23544048-8	2013	Further, the effect of curcumin on alpha-SMA, PAI-1, E-cadherin, TbetaR I and TbetaR II were reversed by ERK inhibitor U0126 or PPARgamma inhibitor BADGE, or PPARgamma shRNA.	Curcumin	23-31	mitogen-activated protein kinase 1	Homo sapiens	105-108
23544048-8	2013	Further, the effect of curcumin on alpha-SMA, PAI-1, E-cadherin, TbetaR I and TbetaR II were reversed by ERK inhibitor U0126 or PPARgamma inhibitor BADGE, or PPARgamma shRNA.	Curcumin	23-31	peroxisome proliferator activated receptor gamma	Homo sapiens	128-137
23544048-8	2013	Further, the effect of curcumin on alpha-SMA, PAI-1, E-cadherin, TbetaR I and TbetaR II were reversed by ERK inhibitor U0126 or PPARgamma inhibitor BADGE, or PPARgamma shRNA.	Curcumin	23-31	peroxisome proliferator activated receptor gamma	Homo sapiens	158-167
23544048-4	2013	We found that curcumin inhibited the EMT as assessed by reduced expression of alpha-SMA and PAI-1, and increased E-cadherin in TGF-beta1 treated proximal tubular epithelial cell HK-2 cells.	Curcumin	14-22	cadherin 1	Homo sapiens	113-123
23544048-10	2013	We conclude that curcumin counteracted TGF-beta1-induced EMT in renal tubular epithelial cells via ERK-dependent and then PPARgamma-dependent pathway.	Curcumin	17-25	transforming growth factor beta 1	Homo sapiens	39-48
23544048-10	2013	We conclude that curcumin counteracted TGF-beta1-induced EMT in renal tubular epithelial cells via ERK-dependent and then PPARgamma-dependent pathway.	Curcumin	17-25	mitogen-activated protein kinase 1	Homo sapiens	99-102
23544048-4	2013	We found that curcumin inhibited the EMT as assessed by reduced expression of alpha-SMA and PAI-1, and increased E-cadherin in TGF-beta1 treated proximal tubular epithelial cell HK-2 cells.	Curcumin	14-22	transforming growth factor beta 1	Homo sapiens	127-136
23544048-10	2013	We conclude that curcumin counteracted TGF-beta1-induced EMT in renal tubular epithelial cells via ERK-dependent and then PPARgamma-dependent pathway.	Curcumin	17-25	peroxisome proliferator activated receptor gamma	Homo sapiens	122-131
23544048-7	2013	On the other hand, in non-Smad pathway curcumin reduced TGF-beta1-induced ERK phosphorylation and PPARgamma phosphorylation, and promoted nuclear translocation of PPARgamma.	Curcumin	39-47	transforming growth factor beta 1	Homo sapiens	56-65
23544048-7	2013	On the other hand, in non-Smad pathway curcumin reduced TGF-beta1-induced ERK phosphorylation and PPARgamma phosphorylation, and promoted nuclear translocation of PPARgamma.	Curcumin	39-47	mitogen-activated protein kinase 1	Homo sapiens	74-77
23544048-7	2013	On the other hand, in non-Smad pathway curcumin reduced TGF-beta1-induced ERK phosphorylation and PPARgamma phosphorylation, and promoted nuclear translocation of PPARgamma.	Curcumin	39-47	peroxisome proliferator activated receptor gamma	Homo sapiens	98-107
23544048-7	2013	On the other hand, in non-Smad pathway curcumin reduced TGF-beta1-induced ERK phosphorylation and PPARgamma phosphorylation, and promoted nuclear translocation of PPARgamma.	Curcumin	39-47	peroxisome proliferator activated receptor gamma	Homo sapiens	163-172
23451189-0	2013	Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-kappaB and Src protein kinase signaling pathways.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	94-103
23451189-0	2013	Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-kappaB and Src protein kinase signaling pathways.	Curcumin	0-8	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	108-111
23451189-7	2013	Curcumin induced apoptosis in both cells by inducing mitochondrial degeneration and cytochrome c release.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	84-96
23451189-9	2013	Curcumin potentiated 5-FU-induced expression or cleavage of pro-apoptotic proteins (caspase-8, -9, -3, PARP and Bax), and down-regulated anti-apoptotic (Bcl-xL) and proliferative (cyclin D1) proteins.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	103-107
23457487-6	2013	This curcumin-mediated down-regulation of DNMT1 expression was concomitant with p15(INK4B) tumor suppressor gene reactivation, hypomethylation of the p15(INK4B) promoter, G1 cell cycle arrest, and induction of tumor cell apoptosis in vitro.	Curcumin	5-13	cyclin dependent kinase inhibitor 2B	Homo sapiens	80-83
23451189-9	2013	Curcumin potentiated 5-FU-induced expression or cleavage of pro-apoptotic proteins (caspase-8, -9, -3, PARP and Bax), and down-regulated anti-apoptotic (Bcl-xL) and proliferative (cyclin D1) proteins.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	112-115
23457487-6	2013	This curcumin-mediated down-regulation of DNMT1 expression was concomitant with p15(INK4B) tumor suppressor gene reactivation, hypomethylation of the p15(INK4B) promoter, G1 cell cycle arrest, and induction of tumor cell apoptosis in vitro.	Curcumin	5-13	cyclin dependent kinase inhibitor 2B	Homo sapiens	84-89
23457487-6	2013	This curcumin-mediated down-regulation of DNMT1 expression was concomitant with p15(INK4B) tumor suppressor gene reactivation, hypomethylation of the p15(INK4B) promoter, G1 cell cycle arrest, and induction of tumor cell apoptosis in vitro.	Curcumin	5-13	cyclin dependent kinase inhibitor 2B	Homo sapiens	150-153
23457487-6	2013	This curcumin-mediated down-regulation of DNMT1 expression was concomitant with p15(INK4B) tumor suppressor gene reactivation, hypomethylation of the p15(INK4B) promoter, G1 cell cycle arrest, and induction of tumor cell apoptosis in vitro.	Curcumin	5-13	cyclin dependent kinase inhibitor 2B	Homo sapiens	154-159
23451189-9	2013	Curcumin potentiated 5-FU-induced expression or cleavage of pro-apoptotic proteins (caspase-8, -9, -3, PARP and Bax), and down-regulated anti-apoptotic (Bcl-xL) and proliferative (cyclin D1) proteins.	Curcumin	0-8	BCL2 like 1	Homo sapiens	153-159
23451189-10	2013	Although 5-FU activated NF-kappaB/PI-3K/Src pathway in CRC cells, this was down-regulated by curcumin treatment through inhibition of IkappaBalpha kinase activation and IkappaBalpha phosphorylation.	Curcumin	93-101	NFKB inhibitor alpha	Homo sapiens	134-146
23451189-10	2013	Although 5-FU activated NF-kappaB/PI-3K/Src pathway in CRC cells, this was down-regulated by curcumin treatment through inhibition of IkappaBalpha kinase activation and IkappaBalpha phosphorylation.	Curcumin	93-101	NFKB inhibitor alpha	Homo sapiens	169-181
23437333-0	2013	Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.	Curcumin	150-158	TNF superfamily member 10	Homo sapiens	64-69
23437361-7	2013	The expression of IL-6, IL-10, IFNgamma, and MCP-1, key chemokines/cytokines implicated in the development of ALI/ARDS, from both the inflammatory infiltrate and whole lung tissue were modulated by curcumin potentially through a reduction in the phosphorylated form of NFkappaB p65.	Curcumin	198-206	interleukin 6	Mus musculus	18-22
23437333-9	2013	The phytochemical curcumin further increased the sensitivity of neurofibromin deficient MPNST cells to TRAIL.	Curcumin	18-26	neurofibromin 1	Homo sapiens	64-77
23437361-7	2013	The expression of IL-6, IL-10, IFNgamma, and MCP-1, key chemokines/cytokines implicated in the development of ALI/ARDS, from both the inflammatory infiltrate and whole lung tissue were modulated by curcumin potentially through a reduction in the phosphorylated form of NFkappaB p65.	Curcumin	198-206	mast cell protease 1	Mus musculus	45-50
23437333-9	2013	The phytochemical curcumin further increased the sensitivity of neurofibromin deficient MPNST cells to TRAIL.	Curcumin	18-26	TNF superfamily member 10	Homo sapiens	103-108
23600205-10	2013	CONCLUSION: Aspirin, sulindac, curcumin and PDTC could all inhibit cisplatin induced NF-kappaB activiation, which could increase cispaltin-induced chemosensativity by augments of apoptosis.	Curcumin	31-39	nuclear factor kappa B subunit 1	Homo sapiens	85-94
24292189-11	2013	Finally, by focusing on neutrophils and CF airway epithelial cells, we identified curcumin as a potent inhibitor of TLR2-mediated inflammatory responses.	Curcumin	82-90	toll like receptor 2	Homo sapiens	116-120
22982865-6	2012	Curcumin treatment, starting at week 10 post-DMH injection for 14 days, reduced the number of ACF (40%), iNOS expression (25%) and arginase activity (73%), and improved redox status by approximately 46%, compared to DMH-treated mice.	Curcumin	0-8	nitric oxide synthase 2, inducible	Mus musculus	105-109
23153397-6	2012	Compounds 4, 6, 7, 10, and 11 showed higher cytotoxic activities (IC(50), 10.3-19.4 muM) than curcumin (IC(50), 31.3-49.2 muM) against human cancer cell lines (A549, HepG2, and MDA-MB-231).	Curcumin	94-102	latexin	Homo sapiens	122-125
23225435-8	2012	Both inhibitors of ABCC1/ABCC2 and depletion of intracellular glutathione levels were able to reverse hypoxia-induced curcumin resistance.	Curcumin	118-126	ATP binding cassette subfamily C member 1	Homo sapiens	19-24
23063543-7	2012	In addition, curcumin pretreatment markedly reduced hepatic oxidative stress and pro inflammatory cytokines, including TNF-alpha and IFN-gamma.	Curcumin	13-21	tumor necrosis factor	Mus musculus	119-128
23063543-7	2012	In addition, curcumin pretreatment markedly reduced hepatic oxidative stress and pro inflammatory cytokines, including TNF-alpha and IFN-gamma.	Curcumin	13-21	interferon gamma	Mus musculus	133-142
22763371-8	2012	RESULTS: Acupuncture combined with curcumin potently reduced serum PDGF levels and selectively disrupted the PDGF-betaR/extracellular signal-regulated kinase (ERK) cascade.	Curcumin	35-43	Eph receptor B1	Rattus norvegicus	109-157
22763371-8	2012	RESULTS: Acupuncture combined with curcumin potently reduced serum PDGF levels and selectively disrupted the PDGF-betaR/extracellular signal-regulated kinase (ERK) cascade.	Curcumin	35-43	Eph receptor B1	Rattus norvegicus	159-162
22763371-10	2012	CONCLUSIONS: The beneficial effects of acupuncture and its combination with curcumin could be attributed to the disruption of PDGF-betaR/ERK pathway and stimulated ECM degradation in the fibrotic liver.	Curcumin	76-84	Eph receptor B1	Rattus norvegicus	137-140
23225435-9	2012	CONCLUSION: ABCC1 and ABCC2 play an important role in hypoxia-induced curcumin resistance in human hepatocellular carcinoma.	Curcumin	70-78	ATP binding cassette subfamily C member 1	Homo sapiens	12-17
22438101-3	2012	Further, perifosine and curcumin synergistically increase intracellular level of reactive oxygen species and ceramide, and downregulate the expression of cyclin D1 and Bcl-2 in colorectal cancer cells.	Curcumin	24-32	BCL2 apoptosis regulator	Homo sapiens	168-173
22823335-2	2012	In this study we tested the hypothesis that curcumin attenuates maladaptive cardiac repair and improves cardiac function after ischaemia and reperfusion by reducing degradation of extracellular matrix (ECM) and inhibiting synthesis of collagens via TGFbeta/Smad-mediated signalling pathway.	Curcumin	44-52	transforming growth factor beta 1	Homo sapiens	249-256
22823335-2	2012	In this study we tested the hypothesis that curcumin attenuates maladaptive cardiac repair and improves cardiac function after ischaemia and reperfusion by reducing degradation of extracellular matrix (ECM) and inhibiting synthesis of collagens via TGFbeta/Smad-mediated signalling pathway.	Curcumin	44-52	SMAD family member 7	Homo sapiens	257-261
22823335-6	2012	In addition to reducing collagen synthesis and fibrosis in the ischaemic/reperfused myocardium, curcumin significantly down-regulated the expression of TGFbeta1 and phospho-Smad2/3, and up-regulated Smad7 and also increased the population of alpha-smooth muscle actin expressing myofibroblasts within the infarcted myocardium relative to the control.	Curcumin	96-104	transforming growth factor beta 1	Homo sapiens	152-160
22823335-6	2012	In addition to reducing collagen synthesis and fibrosis in the ischaemic/reperfused myocardium, curcumin significantly down-regulated the expression of TGFbeta1 and phospho-Smad2/3, and up-regulated Smad7 and also increased the population of alpha-smooth muscle actin expressing myofibroblasts within the infarcted myocardium relative to the control.	Curcumin	96-104	SMAD family member 7	Homo sapiens	199-204
23042094-5	2012	We show that curcumin inhibits translocation of NFkappaB to the nucleus through the inhibition of the IkappaB-kinase (IKKbeta, leading to stabilization of the inhibitor of NFkappaB, IkappaBalpha, in PC-3 prostate carcinoma cells.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	48-56
23042094-5	2012	We show that curcumin inhibits translocation of NFkappaB to the nucleus through the inhibition of the IkappaB-kinase (IKKbeta, leading to stabilization of the inhibitor of NFkappaB, IkappaBalpha, in PC-3 prostate carcinoma cells.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	172-180
23042094-5	2012	We show that curcumin inhibits translocation of NFkappaB to the nucleus through the inhibition of the IkappaB-kinase (IKKbeta, leading to stabilization of the inhibitor of NFkappaB, IkappaBalpha, in PC-3 prostate carcinoma cells.	Curcumin	13-21	NFKB inhibitor alpha	Homo sapiens	182-194
23042094-8	2012	Treatment of the cells with curcumin and siRNA-based knockdown of CXCL1 and -2 induce apoptosis, inhibit proliferation and downregulate several important metastasis-promoting factors like COX2, SPARC and EFEMP.	Curcumin	28-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	188-192
23042094-11	2012	Curcumin disrupts this feedback loop by the inhibition of NFkappaB signaling leading to reduced metastasis formation in vivo.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	58-66
23986968-2	2012	Results indicated that curcumin induced cell toxicity (light microscopy and MTT assay) and apoptosis (AnnexinV-FITC/PI labeling and caspase-3 activity) in these cells.	Curcumin	23-31	caspase 3	Homo sapiens	132-141
23986968-6	2012	On the other hand, addition of N-acetyl cysteine (NAC), an antioxidant, blocked the curcumin-induced ROS production and rescued malignant cells from curcumin-induced apoptosis through caspase-3 deactivation.	Curcumin	84-92	caspase 3	Homo sapiens	184-193
22445325-7	2012	Finally, additional results demonstrated that SNCA inducing both mitochondrial dynamic disorders and neurotoxicity could be ameliorated by curcumin through ERK inhibition, which implied that the agent could be used to prevent and treat PD in the future.	Curcumin	139-147	mitogen-activated protein kinase 1	Homo sapiens	156-159
22324466-0	2012	Curcumin inhibits thrombin-stimulated connective tissue growth factor (CTGF/CCN2) production through c-Jun NH2-terminal kinase suppression in human gingival fibroblasts.	Curcumin	0-8	coagulation factor II, thrombin	Homo sapiens	18-26
22324466-0	2012	Curcumin inhibits thrombin-stimulated connective tissue growth factor (CTGF/CCN2) production through c-Jun NH2-terminal kinase suppression in human gingival fibroblasts.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	101-126
22324466-5	2012	This study investigates the signaling pathway of thrombin-induced CCN2 expression and inhibition of CCN2 expression by curcumin.	Curcumin	119-127	coagulation factor II, thrombin	Homo sapiens	49-57
22324466-10	2012	Curcumin dose dependently inhibited thrombin-induced CCN2 expression through JNK suppression in HGFs.	Curcumin	0-8	coagulation factor II, thrombin	Homo sapiens	36-44
22324466-10	2012	Curcumin dose dependently inhibited thrombin-induced CCN2 expression through JNK suppression in HGFs.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	77-80
22324466-12	2012	Curcumin could effectively inhibit CCN2 expression through JNK suppression.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	59-62
23023821-0	2012	Curcumin induces apoptosis of triple-negative breast cancer cells by             inhibition of EGFR expression.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	95-99
22725663-1	2012	This study was to investigate the effect of concomitantly administered curcumin on the pharmacokinetics of talinolol and association with ABCB1 C3435T genetic polymorphism.	Curcumin	71-79	ATP binding cassette subfamily B member 1	Homo sapiens	138-143
22910273-3	2012	We explored synergistic efficacy of a low dose of curcumin (CCM) and a low dose of paclitaxel (PTX) in HBTSC and human glioblastoma LN18 (p53 mutant and PTEN proficient) and U138MG (p53 mutant and PTEN mutant) cells.	Curcumin	50-58	tumor protein p53	Homo sapiens	138-141
22725663-0	2012	Effects of curcumin on the pharmacokinetics of talinolol in human with ABCB1 polymorphism.	Curcumin	11-19	ATP binding cassette subfamily B member 1	Homo sapiens	71-76
22725663-9	2012	The effect of curcumin on talinolol was associated with ABCB1 genotypes (C3435T).	Curcumin	14-22	ATP binding cassette subfamily B member 1	Homo sapiens	56-61
23194063-1	2012	BACKGROUND: Curcumin inhibits growth of several cancer cell lines, and studies in this laboratory in bladder and pancreatic cancer cells show that curcumin downregulates specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and pro-oncogenic Sp-regulated genes.	Curcumin	12-20	Sp3 transcription factor	Homo sapiens	222-225
23194063-1	2012	BACKGROUND: Curcumin inhibits growth of several cancer cell lines, and studies in this laboratory in bladder and pancreatic cancer cells show that curcumin downregulates specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and pro-oncogenic Sp-regulated genes.	Curcumin	147-155	Sp3 transcription factor	Homo sapiens	222-225
23351311-0	2012	Genistein abrogates G2 arrest induced by curcumin in p53 deficient T47D cells.	Curcumin	41-49	tumor protein p53	Homo sapiens	53-56
23194063-6	2012	Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), survivin, bcl-2, cyclin D1 and NFkappaB (p65 and p50).	Curcumin	0-8	Sp3 transcription factor	Homo sapiens	189-192
23351311-10	2012	RESULTS: In this study curcumin induced G2 arrest on p53 deficient T47D cells at the concentration of 10 muM.	Curcumin	23-31	tumor protein p53	Homo sapiens	53-56
23351311-14	2012	Combining curcumin with high dose of genistein (50 muM) induced necrotic cells.	Curcumin	10-18	latexin	Homo sapiens	51-54
23194063-6	2012	Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), survivin, bcl-2, cyclin D1 and NFkappaB (p65 and p50).	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	238-270
23351311-10	2012	RESULTS: In this study curcumin induced G2 arrest on p53 deficient T47D cells at the concentration of 10 muM.	Curcumin	23-31	latexin	Homo sapiens	105-108
23194063-6	2012	Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), survivin, bcl-2, cyclin D1 and NFkappaB (p65 and p50).	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	272-276
23194063-6	2012	Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), survivin, bcl-2, cyclin D1 and NFkappaB (p65 and p50).	Curcumin	0-8	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	279-312
23194063-6	2012	Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), survivin, bcl-2, cyclin D1 and NFkappaB (p65 and p50).	Curcumin	0-8	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	314-319
23194063-6	2012	Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), survivin, bcl-2, cyclin D1 and NFkappaB (p65 and p50).	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	332-337
23194063-6	2012	Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), survivin, bcl-2, cyclin D1 and NFkappaB (p65 and p50).	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	353-361
23194063-6	2012	Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), survivin, bcl-2, cyclin D1 and NFkappaB (p65 and p50).	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	371-374
23194063-7	2012	Curcumin and RL197 also induced reactive oxygen species (ROS), and cotreatment with the antioxidant glutathione significantly attenuated curcumin- and RL197-induced growth inhibition and downregulation of Sp1, Sp3, Sp4 and Sp-regulated genes.	Curcumin	0-8	Sp3 transcription factor	Homo sapiens	210-213
23194063-7	2012	Curcumin and RL197 also induced reactive oxygen species (ROS), and cotreatment with the antioxidant glutathione significantly attenuated curcumin- and RL197-induced growth inhibition and downregulation of Sp1, Sp3, Sp4 and Sp-regulated genes.	Curcumin	137-145	Sp3 transcription factor	Homo sapiens	210-213
23194063-8	2012	The mechanism of curcumin-/RL197-induced repression of Sp transcription factors was ROS-dependent and due to induction of the Sp repressors ZBTB10 and ZBTB4 and downregulation of microRNAs (miR)-27a, miR-20a and miR-17-5p that regulate these repressors.	Curcumin	17-25	microRNA 20a	Homo sapiens	200-207
23038702-8	2012	Serum CGRP was only decreased in the curcumin group (P &lt; 0.001).	Curcumin	37-45	calcitonin related polypeptide alpha	Homo sapiens	6-10
23443113-6	2012	Curcumin has been widely described to inhibit inducible nitric oxide synthase expression and nitric oxide production, at least in part via direct interference in NF-kappaB activation.	Curcumin	0-8	nitric oxide synthase 2	Homo sapiens	56-77
23552468-8	2012	Furthermore, the pathways of NF-kappaB, NFAT and Nrf2 are functional, interacting on several regulatory steps, and, especially, natural compounds such as curcumin interfere with more than one pathway.	Curcumin	154-162	nuclear factor kappa B subunit 1	Homo sapiens	29-38
23552468-8	2012	Furthermore, the pathways of NF-kappaB, NFAT and Nrf2 are functional, interacting on several regulatory steps, and, especially, natural compounds such as curcumin interfere with more than one pathway.	Curcumin	154-162	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
23058916-3	2012	We previously observed that curcumin and caffeic acid phenethyl ester (CAPE) inhibit CRAC current in Orai1/STIM1-co-expressing HEK293 cells (Nam et al., 2009; Shin et al., 2011) [1,2].	Curcumin	28-36	stromal interaction molecule 1	Homo sapiens	107-112
23038702-10	2012	There were significant correlations between CGRP and IL-6 changes (P = 0.011) and between DLQI and IL-8 changes (P = 0.026) in the curcumin group.	Curcumin	131-139	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
23038702-11	2012	In the curcumin group, changes in serum IL-8 concentrations were found as the significant predictor of DLQI scores (P = 0.026) but none of the independent variables could predict pruritus scores.	Curcumin	7-15	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
22890189-0	2012	ApoE3 mediated polymeric nanoparticles containing curcumin: apoptosis induced in vitro anticancer activity against neuroblastoma cells.	Curcumin	50-58	apolipoprotein E	Homo sapiens	0-5
22963983-5	2012	Immunohistochemical analysis of the aorta revealed that expression of CD36, an Nrf2-regulated gene, was strongly induced by treatment with curcumin.	Curcumin	139-147	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
22820234-0	2012	Curcumin produces antidepressant effects via activating MAPK/ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice.	Curcumin	0-8	mitogen-activated protein kinase 1	Mus musculus	61-64
22820234-5	2012	Chronic administration of curcumin (40 mg/kg, i.p., 21 days) increased BDNF protein levels in the amygdala and this enhancement was suppressed by pretreatment with the extracellular signal-regulated kinase (ERK) inhibitor SL327.	Curcumin	26-34	mitogen-activated protein kinase 1	Mus musculus	168-205
22820234-5	2012	Chronic administration of curcumin (40 mg/kg, i.p., 21 days) increased BDNF protein levels in the amygdala and this enhancement was suppressed by pretreatment with the extracellular signal-regulated kinase (ERK) inhibitor SL327.	Curcumin	26-34	mitogen-activated protein kinase 1	Mus musculus	207-210
22820234-6	2012	Additionally, the increased levels of ERK phosphoryation in the amygdala by curcumin were blocked by the ERK inhibitor, and inhibition of this kinase prevented the antidepressant effects of curcumin.	Curcumin	76-84	mitogen-activated protein kinase 1	Mus musculus	38-41
22820234-6	2012	Additionally, the increased levels of ERK phosphoryation in the amygdala by curcumin were blocked by the ERK inhibitor, and inhibition of this kinase prevented the antidepressant effects of curcumin.	Curcumin	76-84	mitogen-activated protein kinase 1	Mus musculus	105-108
22820234-6	2012	Additionally, the increased levels of ERK phosphoryation in the amygdala by curcumin were blocked by the ERK inhibitor, and inhibition of this kinase prevented the antidepressant effects of curcumin.	Curcumin	190-198	mitogen-activated protein kinase 1	Mus musculus	38-41
22820234-6	2012	Additionally, the increased levels of ERK phosphoryation in the amygdala by curcumin were blocked by the ERK inhibitor, and inhibition of this kinase prevented the antidepressant effects of curcumin.	Curcumin	190-198	mitogen-activated protein kinase 1	Mus musculus	105-108
22820234-8	2012	These results suggest that the antidepressant-like effects of curcumin in the forced swim test are mediated, at least in part, by an ERK-regulated increase of BDNF expression in the amygdala of mice.	Curcumin	62-70	mitogen-activated protein kinase 1	Mus musculus	133-136
22776359-4	2012	RESULTS: There were significant increases in the levels of cell density, gamma-IFN, and CD8, accompanied with significant decrease in the level of CD4, when comparing cultured cells treated with curcumin and taurine with control cultured cells.	Curcumin	195-203	CD4 molecule	Homo sapiens	147-150
22776359-6	2012	Moreover, curcumin/taurine combined therapy enhances immunity by stimulating the CD4(+) T-helper cells with consequent induction of CD8 T-cell responses to lyse tumor cells.	Curcumin	10-18	CD4 molecule	Homo sapiens	81-84
22890189-3	2012	Anionic polymerization method was employed for the preparation of apolipoprotein-E3 mediated curcumin loaded poly(butyl)cyanoacrylate nanoparticles (ApoE3-C-PBCA) and characterized for size, zeta potential, entrapment efficiency, photostability, morphology, and in vitro release study.	Curcumin	93-101	apolipoprotein E	Homo sapiens	149-154
22890189-5	2012	Flow cytometry techniques employed for the detection of anticancer activity revealed enhanced activity of curcumin against SH-SY5Y neuroblastoma cells with ApoE3-C-PBCA compared to CSSS and C-PBCA, and apoptosis being the underlying mechanism.	Curcumin	106-114	apolipoprotein E	Homo sapiens	156-161
22773702-7	2012	The curcumin-treated group showed a lower level of HOMA-IR (3.22 vs. 4.04; P &lt; 0.001) and higher adiponectin (22.46 vs. 18.45; P &lt; 0.05) when compared with the placebo group.	Curcumin	4-12	adiponectin, C1Q and collagen domain containing	Homo sapiens	100-111
22890189-3	2012	Anionic polymerization method was employed for the preparation of apolipoprotein-E3 mediated curcumin loaded poly(butyl)cyanoacrylate nanoparticles (ApoE3-C-PBCA) and characterized for size, zeta potential, entrapment efficiency, photostability, morphology, and in vitro release study.	Curcumin	93-101	apolipoprotein E	Homo sapiens	66-83
23653845-7	2012	RESULTS: The groups that received curcumin 3% and 5% showed a significant decrease in TNFalpha, hs-CRP and Isoprostane serum concentrations compared to the normal saline group, however, these differences were not significant, between the other groups.	Curcumin	34-42	tumor necrosis factor	Rattus norvegicus	86-94
22971638-0	2012	RL66 a second-generation curcumin analog has potent in vivo and in vitro             anticancer activity in ER-negative breast cancer models.	Curcumin	25-33	estrogen receptor 1	Homo sapiens	108-110
22971638-2	2012	1-Methyl-3,5-bis[(E)-4-pyridyl)methylidene]-4-piperidone             (RL66) is a second generation curcumin analog that exhibits potent cytotoxicity             towards a variety of ER-negative breast cancer cells.	Curcumin	99-107	estrogen receptor 1	Homo sapiens	182-184
22922731-0	2012	Curcumin inhibits HCV replication by induction of heme oxygenase-1 and             suppression of AKT.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	98-101
22922731-7	2012	In addition to the heme oxygenase-1 induction, signaling molecule activities of AKT, extracellular signal-regulated kinases (ERK) and nuclear factor-kappaB (NF-kappaB) were inhibited by curcumin.	Curcumin	186-194	AKT serine/threonine kinase 1	Homo sapiens	80-83
22922731-7	2012	In addition to the heme oxygenase-1 induction, signaling molecule activities of AKT, extracellular signal-regulated kinases (ERK) and nuclear factor-kappaB (NF-kappaB) were inhibited by curcumin.	Curcumin	186-194	nuclear factor kappa B subunit 1	Homo sapiens	157-166
22922731-8	2012	Using specific inhibitors of PI3K-AKT, MEK-ERK and NF-kappaB, the results suggested that only PI3K-AKT inhibition is positively involved in curcumin-inhibited HCV replication.	Curcumin	140-148	AKT serine/threonine kinase 1	Homo sapiens	34-37
22922731-8	2012	Using specific inhibitors of PI3K-AKT, MEK-ERK and NF-kappaB, the results suggested that only PI3K-AKT inhibition is positively involved in curcumin-inhibited HCV replication.	Curcumin	140-148	nuclear factor kappa B subunit 1	Homo sapiens	51-60
22922731-8	2012	Using specific inhibitors of PI3K-AKT, MEK-ERK and NF-kappaB, the results suggested that only PI3K-AKT inhibition is positively involved in curcumin-inhibited HCV replication.	Curcumin	140-148	AKT serine/threonine kinase 1	Homo sapiens	99-102
22922731-10	2012	In summary, curcumin inhibited HCV replication by heme oxygenase-1 induction and AKT pathway inhibition.	Curcumin	12-20	AKT serine/threonine kinase 1	Homo sapiens	81-84
22922731-11	2012	Although curcumin also inhibits ERK and NF-kappaB activities, it slightly increased the HCV protein expression.	Curcumin	9-17	nuclear factor kappa B subunit 1	Homo sapiens	40-49
22221674-5	2012	Using the thioacetamide (TAA)-induced hepatic fibrosis animal model, we found that curcumin treatment up-regulated P53 protein expression and Bax messenger RNA (mRNA) expression and down-regulated Bcl-2 mRNA expression.	Curcumin	83-91	B cell leukemia/lymphoma 2	Mus musculus	197-202
22402367-0	2012	Curcumin reduces the cardiac ischemia-reperfusion injury: involvement of the toll-like receptor 2 in cardiomyocytes.	Curcumin	0-8	toll-like receptor 2	Rattus norvegicus	77-97
22402367-2	2012	Toll-like receptor 2 (TLR2), a key mediator of the innate immune system, is involved in myocardial infarction and examined if controlled by curcumin.	Curcumin	140-148	toll-like receptor 2	Rattus norvegicus	0-20
22402367-2	2012	Toll-like receptor 2 (TLR2), a key mediator of the innate immune system, is involved in myocardial infarction and examined if controlled by curcumin.	Curcumin	140-148	toll-like receptor 2	Rattus norvegicus	22-26
22402367-7	2012	In CMs, TLR2 and monocyte chemoattractant protein (MCP)-1 mRNAs were increased by TNF-alpha, PGN or H/R, whereas they were blunted by curcumin.	Curcumin	134-142	toll-like receptor 2	Rattus norvegicus	8-12
22402367-13	2012	These results suggest that selective inhibition of TLR2 by curcumin could be preventive and therapeutic for myocardial infarction.	Curcumin	59-67	toll-like receptor 2	Rattus norvegicus	51-55
22402368-5	2012	In this study, we show that C57BL/6 mice induced to develop EAE express elevated levels of interferon (IFN) gamma and interleukin (IL)-17 in the central nervous system (CNS) and lymphoid organs that decreased significantly following in vivo treatment with curcumin.	Curcumin	256-264	interferon gamma	Mus musculus	91-113
22733496-9	2012	Similarly the increased SOD2, GPx1 and decreased CAT activities in MF were also normalized by vitamin E and curcumin supplementation.	Curcumin	108-116	glutathione peroxidase 1	Rattus norvegicus	30-34
22733496-9	2012	Similarly the increased SOD2, GPx1 and decreased CAT activities in MF were also normalized by vitamin E and curcumin supplementation.	Curcumin	108-116	catalase	Rattus norvegicus	49-52
23095512-7	2012	METHODS: Cell loss was assayed after TE-1, TE-8, KY-5, KY-10, YES-1, and YES-2 cells were exposed to 20-80 muM curcumin for 30 hrs.	Curcumin	111-119	YES proto-oncogene 1, Src family tyrosine kinase	Homo sapiens	62-67
22975311-3	2012	This novel transcriptional mechanism can be inhibited by internally initiated SP-3 and the natural phenol curcumin.	Curcumin	106-114	Sp3 transcription factor	Homo sapiens	78-82
23442673-3	2012	Moreover, curcumin regulated urate transport-related proteins and inhibited activation of the JAK2-STAT3 cascade and overexpression of SOCS3 and TGF-beta1 in the kidneys of fructose-fed rats.	Curcumin	10-18	transforming growth factor, beta 1	Rattus norvegicus	145-154
23442673-4	2012	These results suggested that the anti-hyperuricaemic and renal protective actions of curcumin might be the result of renal NO-mediated JAK2-STAT3 signalling and TGF-beta1 normality, which ameliorated renal endothelial dysfunction to improve renal urate transporter system in this model.	Curcumin	85-93	transforming growth factor, beta 1	Rattus norvegicus	161-170
22960168-8	2012	We identified thiabendazole, carotene and curcumin as claudin-4 inducers, and potassium carbonate as a claudin-4 repressor by using the reporter cells.	Curcumin	42-50	claudin 4	Homo sapiens	54-63
23017833-5	2012	Curcumin suppressed the activation of NF-kappaB via the inhibition of IkappaBalpha phosphorylation, and downregulated the expressions of Bcl-2 and CyclinD1 in ESCC cell lines.	Curcumin	0-8	NFKB inhibitor alpha	Homo sapiens	70-82
23017833-5	2012	Curcumin suppressed the activation of NF-kappaB via the inhibition of IkappaBalpha phosphorylation, and downregulated the expressions of Bcl-2 and CyclinD1 in ESCC cell lines.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	137-142
23017833-8	2012	Besides, curcumin could also inhibit NF-kappaB signaling pathway through downregulation of the IkappaBalpha phosphorylation and induction of cell apoptosis in vivo.	Curcumin	9-17	NFKB inhibitor alpha	Homo sapiens	95-107
22674286-11	2012	Thrombin-mediated CCL2 production was attenuated by the thrombin inhibitor PPACK, the protein kinase Cdelta (PKCdelta) inhibitor rottlerin, the c-Src inhibitor PP2, epidermal growth factor receptor (EGFR) inhibitor AG-1478, MEK inhibitors PD98059 and U0126, or AP-1 inhibitors curcumin and tanshinone IIA.	Curcumin	277-285	coagulation factor II, thrombin	Homo sapiens	0-8
22402368-7	2012	Ex vivo and in vitro treatment with curcumin resulted in a dose-dependent decrease in the secretion of IFNgamma, IL-17, IL-12 and IL-23 in culture.	Curcumin	36-44	interferon gamma	Mus musculus	103-111
22402368-8	2012	The inhibition of EAE by curcumin was also associated with an up-regulation of IL-10, peroxisome proliferator activated receptor gamma and CD4(+)CD25(+-)Foxp3(+) Treg cells in the CNS and lymphoid organs.	Curcumin	25-33	interleukin 10	Mus musculus	79-84
22733496-6	2012	The enhanced transcripts of CAT, GPx1 and GR in hypothyroid rat liver were alleviated by administration of vitamin E and curcumin.	Curcumin	121-129	catalase	Rattus norvegicus	28-31
22733496-6	2012	The enhanced transcripts of CAT, GPx1 and GR in hypothyroid rat liver were alleviated by administration of vitamin E and curcumin.	Curcumin	121-129	glutathione peroxidase 1	Rattus norvegicus	33-37
22733496-8	2012	However, enhanced SOD1, GPx1 and decreased GR activities in PMF were normalized by vitamin E and curcumin.	Curcumin	97-105	superoxide dismutase 1	Rattus norvegicus	18-22
22733496-8	2012	However, enhanced SOD1, GPx1 and decreased GR activities in PMF were normalized by vitamin E and curcumin.	Curcumin	97-105	glutathione peroxidase 1	Rattus norvegicus	24-28
22975311-0	2012	Constitutive autotaxin transcription by Nmyc-amplified and non-amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin.	Curcumin	165-173	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	13-22
22564708-8	2012	Curcumin treatment also markedly decreased NAD(P)H oxidase subunits (p67phox, p22phox, gp91phox), growth factors (transforming growth factor-beta, osteopontin) and myocyte enhancer factor-2 protein expression as well as inhibited NF-kappaB activity at nuclear level.	Curcumin	0-8	cytochrome b-245 alpha chain	Rattus norvegicus	78-85
22711176-8	2012	Suppression of survivin expression resulted in curcumin resistance via the modulation of Bcl-2 and Bax expression.	Curcumin	47-55	BCL2 apoptosis regulator	Homo sapiens	89-94
22711176-8	2012	Suppression of survivin expression resulted in curcumin resistance via the modulation of Bcl-2 and Bax expression.	Curcumin	47-55	BCL2 associated X, apoptosis regulator	Homo sapiens	99-102
22765290-3	2012	In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53.	Curcumin	96-104	AKT serine/threonine kinase 1	Homo sapiens	326-329
22765290-3	2012	In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53.	Curcumin	96-104	mechanistic target of rapamycin kinase	Homo sapiens	330-334
22765290-3	2012	In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53.	Curcumin	96-104	forkhead box O1	Homo sapiens	336-341
22765290-3	2012	In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53.	Curcumin	96-104	tumor protein p53	Homo sapiens	357-360
22954786-8	2012	Knocking down both p300/CBP by RNAi or by chemical inhibition with curcumin greatly reduced XPG acetylation, and a concomitant accumulation of the protein at DNA damage sites was observed.	Curcumin	67-75	CREB binding protein	Homo sapiens	24-27
22978413-8	2012	Furthermore, curcumin significantly attenuated expressions of TGFbeta1, Smad2, phosphorylated Smad2, Smad3, and CTGF and induced expression of the Smad7.	Curcumin	13-21	transforming growth factor, beta 1	Rattus norvegicus	62-70
22840386-8	2012	Furthermore, the expression levels of caspase-3 and the Bax/Bcl-2 ratio were significantly decreased in the aortic walls of curcumin-treated rats.	Curcumin	124-132	BCL2, apoptosis regulator	Rattus norvegicus	60-65
23013352-7	2012	RESULTS: Curcumin, but not placebo, produced the following statistically significant changes: lowering of plasma triglyceride values, lowering of salivary amylase levels, raising of salivary radical scavenging capacities, raising of plasma catalase activities, lowering of plasma beta amyloid protein concentrations, lowering of plasma sICAM readings, increased plasma myeloperoxidase without increased c-reactive protein levels, increased plasma nitric oxide, and decreased plasma alanine amino transferase activities.	Curcumin	9-17	catalase	Homo sapiens	240-248
23013352-7	2012	RESULTS: Curcumin, but not placebo, produced the following statistically significant changes: lowering of plasma triglyceride values, lowering of salivary amylase levels, raising of salivary radical scavenging capacities, raising of plasma catalase activities, lowering of plasma beta amyloid protein concentrations, lowering of plasma sICAM readings, increased plasma myeloperoxidase without increased c-reactive protein levels, increased plasma nitric oxide, and decreased plasma alanine amino transferase activities.	Curcumin	9-17	myeloperoxidase	Homo sapiens	369-384
23013352-7	2012	RESULTS: Curcumin, but not placebo, produced the following statistically significant changes: lowering of plasma triglyceride values, lowering of salivary amylase levels, raising of salivary radical scavenging capacities, raising of plasma catalase activities, lowering of plasma beta amyloid protein concentrations, lowering of plasma sICAM readings, increased plasma myeloperoxidase without increased c-reactive protein levels, increased plasma nitric oxide, and decreased plasma alanine amino transferase activities.	Curcumin	9-17	C-reactive protein	Homo sapiens	403-421
22978413-0	2012	Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats.	Curcumin	14-22	transforming growth factor, beta 1	Rattus norvegicus	48-80
22978413-4	2012	The aim of the study was to investigate the effect of curcumin on liver fibrosis and whether curcumin attenuates the TGF-beta1 signaling pathway.	Curcumin	93-101	transforming growth factor, beta 1	Rattus norvegicus	117-126
22978413-8	2012	Furthermore, curcumin significantly attenuated expressions of TGFbeta1, Smad2, phosphorylated Smad2, Smad3, and CTGF and induced expression of the Smad7.	Curcumin	13-21	SMAD family member 3	Rattus norvegicus	101-106
22978413-8	2012	Furthermore, curcumin significantly attenuated expressions of TGFbeta1, Smad2, phosphorylated Smad2, Smad3, and CTGF and induced expression of the Smad7.	Curcumin	13-21	SMAD family member 7	Rattus norvegicus	147-152
22978413-9	2012	CONCLUSIONS: Curcumin significantly attenuated the severity of CCl4-induced liver inflammation and fibrosis through inhibition of TGF-beta1/Smad signalling pathway and CTGF expression.	Curcumin	13-21	C-C motif chemokine ligand 4	Rattus norvegicus	63-67
22978413-9	2012	CONCLUSIONS: Curcumin significantly attenuated the severity of CCl4-induced liver inflammation and fibrosis through inhibition of TGF-beta1/Smad signalling pathway and CTGF expression.	Curcumin	13-21	transforming growth factor, beta 1	Rattus norvegicus	130-139
22978413-9	2012	CONCLUSIONS: Curcumin significantly attenuated the severity of CCl4-induced liver inflammation and fibrosis through inhibition of TGF-beta1/Smad signalling pathway and CTGF expression.	Curcumin	13-21	SMAD family member 7	Rattus norvegicus	140-144
22687757-8	2012	Furthermore, R7L10-curcumin more efficiently decreased TNF-alpha level in lipopolysaccharide (LPS)-activated Raw264.7 macrophage cells than curcumin only.	Curcumin	19-27	tumor necrosis factor	Mus musculus	55-64
27847452-1	2012	The present investigation reports the protective effects of curcumin (CMN) and vitamin E against CCl4 induced oxidative stress and nephrotoxicity in rats.	Curcumin	60-68	C-C motif chemokine ligand 4	Rattus norvegicus	97-101
27847452-10	2012	However, curcumin and vitamin E treatment prevented kidney damage induced by CCl4.	Curcumin	9-17	C-C motif chemokine ligand 4	Rattus norvegicus	77-81
22921746-0	2012	Curcumin suppresses the TPA-induced invasion through inhibition of PKCalpha-dependent MMP-expression in MCF-7 human breast cancer cells.	Curcumin	0-8	protein kinase C alpha	Homo sapiens	67-75
22921746-6	2012	Also, curcumin strongly repressed the TPA-induced phosphorylation of p38 and JNK and inhibited TPA-induced translocation of PKCalpha from the cytosol to the membrane, but did not affect the translocation of PKCdelta.	Curcumin	6-14	mitogen-activated protein kinase 14	Homo sapiens	69-72
22921746-6	2012	Also, curcumin strongly repressed the TPA-induced phosphorylation of p38 and JNK and inhibited TPA-induced translocation of PKCalpha from the cytosol to the membrane, but did not affect the translocation of PKCdelta.	Curcumin	6-14	mitogen-activated protein kinase 8	Homo sapiens	77-80
22921746-6	2012	Also, curcumin strongly repressed the TPA-induced phosphorylation of p38 and JNK and inhibited TPA-induced translocation of PKCalpha from the cytosol to the membrane, but did not affect the translocation of PKCdelta.	Curcumin	6-14	protein kinase C alpha	Homo sapiens	124-132
22921746-7	2012	These results indicate that curcumin-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the PKCalpha, MAPK and NF-kappaB/AP-1 pathway in MCF-7 cells.	Curcumin	28-36	protein kinase C alpha	Homo sapiens	139-147
22687757-11	2012	In addition, R7L10-curcumin decreased TNF-alpha level in lung tissues in an acute lung injury mouse model.	Curcumin	19-27	tumor necrosis factor	Mus musculus	38-47
22705896-0	2012	Cycle arrest and apoptosis in MDA-MB-231/Her2 cells induced by curcumin.	Curcumin	63-71	erb-b2 receptor tyrosine kinase 2	Homo sapiens	41-45
22710975-0	2012	RL71, a second-generation curcumin analog, induces apoptosis and downregulates             Akt in ER-negative breast cancer cells.	Curcumin	26-34	AKT serine/threonine kinase 1	Homo sapiens	91-94
22705896-3	2012	Curcumin, the main constituent of turmeric, has been found to stabilize p27 levels in breast cancer, but whether this effect is mediated through changes in Skp2 or Her2 expression remains unclear.	Curcumin	0-8	dynactin subunit 6	Homo sapiens	72-75
22705896-4	2012	This study investigates whether curcumin inhibits Skp2-mediated p27 ubiquitination in Her2/Skp2-overexpressing cancer cell lines (MDA-MB-231/Her2 cells).	Curcumin	32-40	dynactin subunit 6	Homo sapiens	64-67
22705896-4	2012	This study investigates whether curcumin inhibits Skp2-mediated p27 ubiquitination in Her2/Skp2-overexpressing cancer cell lines (MDA-MB-231/Her2 cells).	Curcumin	32-40	erb-b2 receptor tyrosine kinase 2	Homo sapiens	86-90
22705896-5	2012	The results show that curcumin represses cell proliferation, induces G1 arrest at a lower dosage (30muM), triggers apoptosis at a higher dosage (50muM) and blocks cell migration in MDA-MB-231/Her2 cells.	Curcumin	22-30	erb-b2 receptor tyrosine kinase 2	Homo sapiens	192-196
22705896-6	2012	A low dose of curcumin increases p27 and decreases Skp2, Her2, Cyclin E, CDK kinases in a time- and dose-dependent manner, suggesting that p27, Skp2 and Her2 may be involved in the growth inhibition in MDA-MB-231/Her2 cells induced by curcumin.	Curcumin	14-22	dynactin subunit 6	Homo sapiens	33-36
22705896-6	2012	A low dose of curcumin increases p27 and decreases Skp2, Her2, Cyclin E, CDK kinases in a time- and dose-dependent manner, suggesting that p27, Skp2 and Her2 may be involved in the growth inhibition in MDA-MB-231/Her2 cells induced by curcumin.	Curcumin	14-22	erb-b2 receptor tyrosine kinase 2	Homo sapiens	57-61
22705896-6	2012	A low dose of curcumin increases p27 and decreases Skp2, Her2, Cyclin E, CDK kinases in a time- and dose-dependent manner, suggesting that p27, Skp2 and Her2 may be involved in the growth inhibition in MDA-MB-231/Her2 cells induced by curcumin.	Curcumin	14-22	dynactin subunit 6	Homo sapiens	139-142
22705896-6	2012	A low dose of curcumin increases p27 and decreases Skp2, Her2, Cyclin E, CDK kinases in a time- and dose-dependent manner, suggesting that p27, Skp2 and Her2 may be involved in the growth inhibition in MDA-MB-231/Her2 cells induced by curcumin.	Curcumin	14-22	erb-b2 receptor tyrosine kinase 2	Homo sapiens	153-157
22705896-6	2012	A low dose of curcumin increases p27 and decreases Skp2, Her2, Cyclin E, CDK kinases in a time- and dose-dependent manner, suggesting that p27, Skp2 and Her2 may be involved in the growth inhibition in MDA-MB-231/Her2 cells induced by curcumin.	Curcumin	14-22	erb-b2 receptor tyrosine kinase 2	Homo sapiens	153-157
22705896-6	2012	A low dose of curcumin increases p27 and decreases Skp2, Her2, Cyclin E, CDK kinases in a time- and dose-dependent manner, suggesting that p27, Skp2 and Her2 may be involved in the growth inhibition in MDA-MB-231/Her2 cells induced by curcumin.	Curcumin	235-243	dynactin subunit 6	Homo sapiens	139-142
22705896-6	2012	A low dose of curcumin increases p27 and decreases Skp2, Her2, Cyclin E, CDK kinases in a time- and dose-dependent manner, suggesting that p27, Skp2 and Her2 may be involved in the growth inhibition in MDA-MB-231/Her2 cells induced by curcumin.	Curcumin	235-243	erb-b2 receptor tyrosine kinase 2	Homo sapiens	153-157
22705896-6	2012	A low dose of curcumin increases p27 and decreases Skp2, Her2, Cyclin E, CDK kinases in a time- and dose-dependent manner, suggesting that p27, Skp2 and Her2 may be involved in the growth inhibition in MDA-MB-231/Her2 cells induced by curcumin.	Curcumin	235-243	erb-b2 receptor tyrosine kinase 2	Homo sapiens	153-157
22705896-7	2012	However, higher doses of curcumin produce a dose-dependent apoptotic death in MDA-MB-231/Her2 cells, which is related to cleaved forms of PARP and caspase 3.	Curcumin	25-33	erb-b2 receptor tyrosine kinase 2	Homo sapiens	89-93
22705896-7	2012	However, higher doses of curcumin produce a dose-dependent apoptotic death in MDA-MB-231/Her2 cells, which is related to cleaved forms of PARP and caspase 3.	Curcumin	25-33	caspase 3	Homo sapiens	147-156
22705896-8	2012	The findings indicate that curcumin is of potential value for the chemoprevention of breast cancer, especially in breast cancer with Skp2/Her2 overexpression.	Curcumin	27-35	erb-b2 receptor tyrosine kinase 2	Homo sapiens	138-142
22156994-0	2012	Curcumin:  a novel Stat3 pathway inhibitor for chemoprevention of lung cancer.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	19-24
22788991-4	2012	Curcumin, genistein, epigallocatechin-gallate, equol, and resveratrol efficiently killed both androgen-receptor positive (22Rv1) and negative cell lines (PC-3, DU145) in combination with adenoviral mutants.	Curcumin	0-8	androgen receptor	Homo sapiens	94-111
22156994-8	2012	In-vitro studies with curcuminoid complex demonstrated that the activity of Stat3 in both normal bronchoepithelial cells and lung cancer-derived cells is sensitive to curcumin exposure.	Curcumin	22-30	signal transducer and activator of transcription 3	Mus musculus	76-81
22156994-9	2012	In a dose-dependent manner, curcumin treatment resulted in significant suppression of Stat3 phosphorylation and reduction in the proliferative capacity of both cell types.	Curcumin	28-36	signal transducer and activator of transcription 3	Mus musculus	86-91
22156994-10	2012	In the preclinical trial with rodent models, curcumin reduced Stat3-P and the proliferative markers CycD1 and Mcm2 in mice lung tissues in vivo.	Curcumin	45-53	signal transducer and activator of transcription 3	Mus musculus	62-67
22156994-11	2012	These culture and preclinical studies indicate that the activity of the Stat3 pathway can be suppressed by curcumin treatment, concomitant with a reduction in cell proliferation, supporting our hypothesis that inhibition of the Stat3 pathway represents at least one important mechanism by which curcumin elicits its effects on the bronchoepithelium.	Curcumin	107-115	signal transducer and activator of transcription 3	Mus musculus	72-77
22156994-11	2012	These culture and preclinical studies indicate that the activity of the Stat3 pathway can be suppressed by curcumin treatment, concomitant with a reduction in cell proliferation, supporting our hypothesis that inhibition of the Stat3 pathway represents at least one important mechanism by which curcumin elicits its effects on the bronchoepithelium.	Curcumin	107-115	signal transducer and activator of transcription 3	Mus musculus	228-233
22156994-11	2012	These culture and preclinical studies indicate that the activity of the Stat3 pathway can be suppressed by curcumin treatment, concomitant with a reduction in cell proliferation, supporting our hypothesis that inhibition of the Stat3 pathway represents at least one important mechanism by which curcumin elicits its effects on the bronchoepithelium.	Curcumin	295-303	signal transducer and activator of transcription 3	Mus musculus	72-77
22156994-11	2012	These culture and preclinical studies indicate that the activity of the Stat3 pathway can be suppressed by curcumin treatment, concomitant with a reduction in cell proliferation, supporting our hypothesis that inhibition of the Stat3 pathway represents at least one important mechanism by which curcumin elicits its effects on the bronchoepithelium.	Curcumin	295-303	signal transducer and activator of transcription 3	Mus musculus	228-233
22683883-0	2012	Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression.	Curcumin	22-30	toll-like receptor 4	Rattus norvegicus	130-156
22683883-6	2012	Treatment with curcumin significantly attenuated CCl(4)-induce liver injury, hepatic inflammation and reduced the levels of proinflammatory mediators (TNF-alpha, IL-6 and MCP-1).	Curcumin	15-23	tumor necrosis factor	Rattus norvegicus	151-160
22683883-6	2012	Treatment with curcumin significantly attenuated CCl(4)-induce liver injury, hepatic inflammation and reduced the levels of proinflammatory mediators (TNF-alpha, IL-6 and MCP-1).	Curcumin	15-23	interleukin 6	Rattus norvegicus	162-166
22683883-7	2012	Moreover, curcumin significantly inhibited extracellular matrix deposition, reduced the number of activated stellate cells, and decreased the levels of HMGB1, TLR4 and TLR2 expression in the rat model of fibrogenesis.	Curcumin	10-18	toll-like receptor 4	Rattus norvegicus	159-163
22683883-7	2012	Moreover, curcumin significantly inhibited extracellular matrix deposition, reduced the number of activated stellate cells, and decreased the levels of HMGB1, TLR4 and TLR2 expression in the rat model of fibrogenesis.	Curcumin	10-18	toll-like receptor 2	Rattus norvegicus	168-172
22683883-8	2012	These results suggest that curcumin could be an effective agent for preventing liver fibrosis and its mechanism may in part be a consequence of the reduction TLR2, TLR4 and HMGB1 expression.	Curcumin	27-35	toll-like receptor 2	Rattus norvegicus	158-162
22683883-8	2012	These results suggest that curcumin could be an effective agent for preventing liver fibrosis and its mechanism may in part be a consequence of the reduction TLR2, TLR4 and HMGB1 expression.	Curcumin	27-35	toll-like receptor 4	Rattus norvegicus	164-168
22692588-6	2012	Not only did curcumin treatment increase mitochondrial DNA (mtDNA) copy number in hepatocytes, but it also increased levels of transcriptional factors that regulate mitochondrial biogenesis, including peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC1alpha), nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (Tfam).	Curcumin	13-21	PPARG coactivator 1 alpha	Homo sapiens	201-268
22692588-6	2012	Not only did curcumin treatment increase mitochondrial DNA (mtDNA) copy number in hepatocytes, but it also increased levels of transcriptional factors that regulate mitochondrial biogenesis, including peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC1alpha), nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (Tfam).	Curcumin	13-21	PPARG coactivator 1 alpha	Homo sapiens	270-279
22692588-6	2012	Not only did curcumin treatment increase mitochondrial DNA (mtDNA) copy number in hepatocytes, but it also increased levels of transcriptional factors that regulate mitochondrial biogenesis, including peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC1alpha), nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (Tfam).	Curcumin	13-21	transcription factor A, mitochondrial	Homo sapiens	322-358
22692588-6	2012	Not only did curcumin treatment increase mitochondrial DNA (mtDNA) copy number in hepatocytes, but it also increased levels of transcriptional factors that regulate mitochondrial biogenesis, including peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC1alpha), nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (Tfam).	Curcumin	13-21	transcription factor A, mitochondrial	Homo sapiens	360-364
22751848-7	2012	The induction of signal transducer and activator of transcription 3 phosphorylation by curcumin resulted in the downregulation of the suppressor of cytokine signaling 3 in the liver of obese mice.	Curcumin	87-95	signal transducer and activator of transcription 3	Mus musculus	17-67
22751848-10	2012	By contrast, obese mice treated with curcumin showed normalized mtDNA, NRF1 and Tfam gene expression, reduced hepatic nuclear factor-kappaB activities and levels of thiobarbituric acid reactive substances (TBARS) and restored mitochondrial oxidative metabolism and biogenesis.	Curcumin	37-45	nuclear respiratory factor 1	Mus musculus	71-75
22710975-2	2012	RL71 is a second-generation curcumin analog that exhibits potent cytotoxicity towards a variety of ER-negative breast cancer cells.	Curcumin	28-36	estrogen receptor 1	Homo sapiens	99-101
22739211-0	2012	Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-25
22739211-4	2012	Under hypoxia-mimicking conditions (CoCl(2) treatment) in AtT20 and GH3 cells as well as in all human pituitary adenoma cell cultures (n=8) studied, curcumin strongly suppressed the induction of mRNA synthesis and protein production of HIF1A, the regulated subunit of the hypoxia-induced transcription factor HIF1.	Curcumin	149-157	hypoxia inducible factor 1 subunit alpha	Homo sapiens	236-241
22739211-4	2012	Under hypoxia-mimicking conditions (CoCl(2) treatment) in AtT20 and GH3 cells as well as in all human pituitary adenoma cell cultures (n=8) studied, curcumin strongly suppressed the induction of mRNA synthesis and protein production of HIF1A, the regulated subunit of the hypoxia-induced transcription factor HIF1.	Curcumin	149-157	hypoxia inducible factor 1 subunit alpha	Homo sapiens	236-240
22739211-0	2012	Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	40-45
22739211-2	2012	Here we have studied in rodent and human pituitary tumour cells the influence of curcumin on the production of hypoxia inducible factor 1alpha (HIF1A) and vascular endothelial growth factor A (VEGFA), two key components involved in tumour neovascularisation through angiogenesis.	Curcumin	81-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-142
22739211-2	2012	Here we have studied in rodent and human pituitary tumour cells the influence of curcumin on the production of hypoxia inducible factor 1alpha (HIF1A) and vascular endothelial growth factor A (VEGFA), two key components involved in tumour neovascularisation through angiogenesis.	Curcumin	81-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	144-149
22739211-2	2012	Here we have studied in rodent and human pituitary tumour cells the influence of curcumin on the production of hypoxia inducible factor 1alpha (HIF1A) and vascular endothelial growth factor A (VEGFA), two key components involved in tumour neovascularisation through angiogenesis.	Curcumin	81-89	vascular endothelial growth factor A	Homo sapiens	155-191
22798207-4	2012	We have previously shown that the naturally occurring compound curcumin can sensitize SK-N-AS cells to TRAIL.	Curcumin	63-71	TNF superfamily member 10	Homo sapiens	103-108
22798207-6	2012	Furthermore, we show that curcumin and TRAIL co-treatment induces complete maturation and activation of caspase-3 in both cell lines.	Curcumin	26-34	caspase 3	Homo sapiens	104-113
22798207-8	2012	Moreover, TRAIL co-treatment with bisindolylmaleimide XI or curcumin resulted in down-regulation of X-linked inhibitor of apoptosis protein.	Curcumin	60-68	TNF superfamily member 10	Homo sapiens	10-15
22909087-0	2012	Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity.	Curcumin	26-34	toll like receptor 2	Homo sapiens	150-154
22974604-7	2012	Curcumin treatments effectively attenuated the rats" pulmonary inflammation responses (as shown by reduced alveolar damage), decreased serum malondialdehyde and surfactant protein D levels, and inhibited the expressions of tumor necrosis factor alpha and interleukin-1beta.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	223-250
22974604-7	2012	Curcumin treatments effectively attenuated the rats" pulmonary inflammation responses (as shown by reduced alveolar damage), decreased serum malondialdehyde and surfactant protein D levels, and inhibited the expressions of tumor necrosis factor alpha and interleukin-1beta.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	255-272
21989768-6	2012	To increase its efficacy, we have linked curcumin through a cleavable arm to an antibody (Ab) against the melanoma surface antigen Muc18.	Curcumin	41-49	melanoma cell adhesion molecule	Mus musculus	131-136
22703560-7	2012	In vitro, curcumin-derived hydrogels showed selective cytotoxicity against MDA-MB-231 (IC(50) 9 muM) breast cancer cells but no cytotoxicity to noncancerous quiescent human dermal fibroblasts even at high curcumin concentrations (160 muM).	Curcumin	10-18	latexin	Homo sapiens	96-99
22703560-7	2012	In vitro, curcumin-derived hydrogels showed selective cytotoxicity against MDA-MB-231 (IC(50) 9 muM) breast cancer cells but no cytotoxicity to noncancerous quiescent human dermal fibroblasts even at high curcumin concentrations (160 muM).	Curcumin	10-18	latexin	Homo sapiens	234-237
22751487-1	2012	Curcumin (Hcur) as a cellular imaging and PDT agent shows remarkable photocytotoxicity in HeLa cells in visible light of 400-700 nm giving IC(50) = 8.2 +- 0.2 muM and its degradation is arrested on formation of photocytotoxic dipyridophenazine (dppz) complex [VO(cur)(dppz)Cl] (IC(50) = 3.3 +- 0.4 muM), while both are less toxic in the dark.	Curcumin	0-8	latexin	Homo sapiens	159-162
22751487-1	2012	Curcumin (Hcur) as a cellular imaging and PDT agent shows remarkable photocytotoxicity in HeLa cells in visible light of 400-700 nm giving IC(50) = 8.2 +- 0.2 muM and its degradation is arrested on formation of photocytotoxic dipyridophenazine (dppz) complex [VO(cur)(dppz)Cl] (IC(50) = 3.3 +- 0.4 muM), while both are less toxic in the dark.	Curcumin	0-8	latexin	Homo sapiens	298-301
22653966-3	2012	Curcumin induces the activation of caspase-8, -2, and -9, alteration of mitochondrial membrane potential, release of cytochrome c, and activation of caspase-3 and concomitant PARP cleavage, but the addition of caspase inhibitors only partially blocked the curcumin-mediated apoptosis.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	117-129
22653966-3	2012	Curcumin induces the activation of caspase-8, -2, and -9, alteration of mitochondrial membrane potential, release of cytochrome c, and activation of caspase-3 and concomitant PARP cleavage, but the addition of caspase inhibitors only partially blocked the curcumin-mediated apoptosis.	Curcumin	0-8	caspase 3	Homo sapiens	149-158
22653966-4	2012	Curcumin also downregulates the expression of antiapoptotic proteins c-FLIP, Bcl-xL, cellular inhibitor of apoptosis protein, and X-linked IAP in a ROS-dependent manner.	Curcumin	0-8	CASP8 and FADD like apoptosis regulator	Homo sapiens	69-75
22653966-4	2012	Curcumin also downregulates the expression of antiapoptotic proteins c-FLIP, Bcl-xL, cellular inhibitor of apoptosis protein, and X-linked IAP in a ROS-dependent manner.	Curcumin	0-8	BCL2 like 1	Homo sapiens	77-83
22909087-0	2012	Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity.	Curcumin	26-34	mitogen-activated protein kinase 8	Homo sapiens	170-173
22909087-4	2012	Different extracts of curcuma as well as curcumin (= a component selected based on results with curcuma extracts and HPLC/MS analysis) were tested for their ability to reduce mRNA expression of proinflammatory cytokines and matrix degrading enzymes after 6 hours (real-time RT-PCR), followed by analysis of typical inflammatory signaling mechanisms such as NF-kappaB (Western Blot, Transcription Factor Assay), MAP kinases (Western Blot) and Toll-like receptors (real-time RT-PCR).	Curcumin	41-49	nuclear factor kappa B subunit 1	Homo sapiens	357-366
22909087-7	2012	The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha.	Curcumin	27-35	interleukin 1 beta	Homo sapiens	121-129
22909087-7	2012	The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha.	Curcumin	27-35	interleukin 6	Homo sapiens	131-135
22909087-7	2012	The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha.	Curcumin	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
22909087-7	2012	The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha.	Curcumin	27-35	matrix metallopeptidase 3	Homo sapiens	149-153
22909087-7	2012	The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha.	Curcumin	27-35	matrix metallopeptidase 13	Homo sapiens	158-163
22909087-7	2012	The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha.	Curcumin	27-35	tumor necrosis factor	Homo sapiens	200-209
22909087-8	2012	Pathway analysis indicated that curcumin did not show involvement of NF-kappaB, but down-regulated TLR2 expression and inhibited the MAP kinase JNK while activating p38 and ERK.	Curcumin	32-40	toll like receptor 2	Homo sapiens	99-103
22909087-8	2012	Pathway analysis indicated that curcumin did not show involvement of NF-kappaB, but down-regulated TLR2 expression and inhibited the MAP kinase JNK while activating p38 and ERK.	Curcumin	32-40	mitogen-activated protein kinase 8	Homo sapiens	144-147
22909087-8	2012	Pathway analysis indicated that curcumin did not show involvement of NF-kappaB, but down-regulated TLR2 expression and inhibited the MAP kinase JNK while activating p38 and ERK.	Curcumin	32-40	mitogen-activated protein kinase 14	Homo sapiens	165-168
22909087-8	2012	Pathway analysis indicated that curcumin did not show involvement of NF-kappaB, but down-regulated TLR2 expression and inhibited the MAP kinase JNK while activating p38 and ERK.	Curcumin	32-40	mitogen-activated protein kinase 1	Homo sapiens	173-176
22776204-6	2012	When cells were treated with alcohol plus 25 muM curcumin, the hyperacetylation of H3K9 and over-expression of GATA4 and Mef2c by alcohol was reversed.	Curcumin	49-57	GATA binding protein 4	Mus musculus	111-116
22776204-6	2012	When cells were treated with alcohol plus 25 muM curcumin, the hyperacetylation of H3K9 and over-expression of GATA4 and Mef2c by alcohol was reversed.	Curcumin	49-57	myocyte enhancer factor 2C	Mus musculus	121-126
22594559-5	2012	SKI-II facilitated curcumin-induced ceramide production, p38 activation and Akt inhibition.	Curcumin	19-27	mitogen-activated protein kinase 14	Homo sapiens	57-60
22352842-0	2012	Curcumin inhibits gene expression of receptor for advanced glycation end-products (RAGE) in hepatic stellate cells in vitro by elevating PPARgamma activity and attenuating oxidative stress.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	137-146
22352842-12	2012	Curcumin at 20 microM eliminated the AGE effects, which required the activation of PPARgamma.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	83-92
22352842-14	2012	CONCLUSION AND IMPLICATIONS: Curcumin suppressed gene expression of RAGE by elevating the activity of PPARgamma and attenuating oxidative stress, leading to the elimination of the AGE effects on the activation of HSCs.	Curcumin	29-37	peroxisome proliferator activated receptor gamma	Homo sapiens	102-111
22594559-5	2012	SKI-II facilitated curcumin-induced ceramide production, p38 activation and Akt inhibition.	Curcumin	19-27	AKT serine/threonine kinase 1	Homo sapiens	76-79
22594559-6	2012	Inhibition of p38 by the pharmacological inhibitor (SB 203580), a dominant-negative expression vector, or by RNAi diminished curcumin and SKI-II co-administration-induced ovarian cancer cell apoptosis.	Curcumin	125-133	mitogen-activated protein kinase 14	Homo sapiens	14-17
22594559-7	2012	In addition, restoring Akt activation introducing a constitutively active Akt, or inhibiting ceramide production by fumonisin B1 also inhibited the curcumin plus SKI-II co-administration-induced in vitro anti-ovarian cancer effect, suggesting that ceramide accumulation, p38 activation and Akt inhibition are downstream effectors.	Curcumin	148-156	AKT serine/threonine kinase 1	Homo sapiens	23-26
22594559-7	2012	In addition, restoring Akt activation introducing a constitutively active Akt, or inhibiting ceramide production by fumonisin B1 also inhibited the curcumin plus SKI-II co-administration-induced in vitro anti-ovarian cancer effect, suggesting that ceramide accumulation, p38 activation and Akt inhibition are downstream effectors.	Curcumin	148-156	mitogen-activated protein kinase 14	Homo sapiens	271-274
22507634-7	2012	The inhibition of neutrophil elastase-induced proliferation by curcumin was dependent on the PI3K/Akt pathway.	Curcumin	63-71	thymoma viral proto-oncogene 1	Mus musculus	98-101
22751853-0	2012	Novel curcumin analogue UBS109 potently stimulates osteoblastogenesis and suppresses osteoclastogenesis: involvement in Smad activation and NF-kappaB inhibition.	Curcumin	6-14	nuclear factor kappa B subunit 1	Homo sapiens	140-149
22507634-8	2012	Knockdown of alpha1-antitrypsin by siRNA further enhanced the tumor cell proliferation induced by neutrophil elastase and significantly blocked the anti-proliferation effect of curcumin against neutrophil elastase.	Curcumin	177-185	serpin family A member 1	Homo sapiens	13-31
22507634-0	2012	Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of alpha1-antitrypsin in lung cancer.	Curcumin	0-8	serpin family A member 1	Homo sapiens	97-115
22507634-6	2012	We found that curcumin counteracted the decrease of alpha1-antitrypsin induced by neutrophil elastase by inducing the promoter activity of alpha1-antitrypsin and promoting its expression in A549 cells.	Curcumin	14-22	serpin family A member 1	Homo sapiens	52-70
22507634-10	2012	We further showed that curcumin upregulated the level of alpha1-antitrypsin in primary tumor tissue by promoting its local expression, and the protein level of neutrophil elastase in tumor tissue was obviously decreased in mice treated with curcumin.	Curcumin	23-31	serpin family A member 1	Homo sapiens	57-75
22507634-6	2012	We found that curcumin counteracted the decrease of alpha1-antitrypsin induced by neutrophil elastase by inducing the promoter activity of alpha1-antitrypsin and promoting its expression in A549 cells.	Curcumin	14-22	serpin family A member 1	Homo sapiens	139-157
22507634-10	2012	We further showed that curcumin upregulated the level of alpha1-antitrypsin in primary tumor tissue by promoting its local expression, and the protein level of neutrophil elastase in tumor tissue was obviously decreased in mice treated with curcumin.	Curcumin	241-249	serpin family A member 1	Homo sapiens	57-75
22507634-11	2012	Overall, our results suggest that neutrophil elastase and alpha1-antitrypsin play important roles in modulating lung tumor proliferation in inflammatory microenvironment and curcumin inhibits neutrophil elastase-induced tumor proliferation via upregulating alpha1-antitrypsin expression in vitro and in vivo.	Curcumin	174-182	serpin family A member 1	Homo sapiens	257-275
22753158-5	2012	In agreement with this hypothesis, we observed a reduction (-37%) in macrophage infiltration in the plaque, as measured by immunohistochemistry, and, in vitro, a lower adhesion of monocytes to TNF-alpha-stimulated endothelial cells (-32%) after exposure to a nutritionally achievable concentration of curcumin.	Curcumin	301-309	tumor necrosis factor	Mus musculus	193-202
22753158-6	2012	These changes in gene expression could be related to the observed increased expression of IkappaB protein and decrease of TNF-alpha-induced NF-kappaB/DNA binding and NF-kappaB-transcriptional activity upon exposure to curcumin.	Curcumin	218-226	tumor necrosis factor	Mus musculus	122-131
22753158-6	2012	These changes in gene expression could be related to the observed increased expression of IkappaB protein and decrease of TNF-alpha-induced NF-kappaB/DNA binding and NF-kappaB-transcriptional activity upon exposure to curcumin.	Curcumin	218-226	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	140-149
22753158-6	2012	These changes in gene expression could be related to the observed increased expression of IkappaB protein and decrease of TNF-alpha-induced NF-kappaB/DNA binding and NF-kappaB-transcriptional activity upon exposure to curcumin.	Curcumin	218-226	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	166-175
22753158-7	2012	CONCLUSION: Our findings pointed out that the antiatherogenic effect of curcumin could be linked to its effect on gene networks and cell functions related to leukocyte adhesion and transendothelial migration via NF-kappaB-dependent pathways.	Curcumin	72-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	212-221
22538404-10	2012	PD98059, a mitogen extracellular kinase 1/2 inhibitor, and curcumin, an Egr1 inhibitor, blocked the arachidonic acid-mediated upregulation of TNFalpha in Kupffer cells.	Curcumin	59-67	early growth response 1	Rattus norvegicus	72-76
22944278-7	2012	RESULTS: Curcumin reduced the FeNTA-induced hepatocytic apoptosis by 46.65% and significantly down-regulated the protein levels of Bcl-2 and Bcl-XL.	Curcumin	9-17	BCL2 apoptosis regulator	Homo sapiens	131-136
22944278-7	2012	RESULTS: Curcumin reduced the FeNTA-induced hepatocytic apoptosis by 46.65% and significantly down-regulated the protein levels of Bcl-2 and Bcl-XL.	Curcumin	9-17	BCL2 like 1	Homo sapiens	141-147
22944278-9	2012	The curcumin treatment reduced FeNTA-caused production of ROS and caspase-3 activity by 45.01% and 59.71% respectively.	Curcumin	4-12	caspase 3	Homo sapiens	66-75
22076484-4	2012	The decreased translated products (SOD1 and SOD2) and the unchanged activity of SOD in cerebral cortex of PTU-treated rats were increased on supplementation of curcumin to the hypothyroid rats.	Curcumin	160-168	superoxide dismutase 1	Rattus norvegicus	35-39
22076484-5	2012	Declined translated products of SOD1 and SOD2 in cerebellum of PTU-treated rats were alleviated on administration of curcumin to hypothyroid rats.	Curcumin	117-125	superoxide dismutase 1	Rattus norvegicus	32-36
22725248-4	2012	The construction method is very versatile and was illustrated by the coupling of a small library of ligands (e.g., biotin, curcumin derivatives, and antibody), resulting in high affinity toward (i) murine lung carcinoma (M109) and human breast cancer (MCF7) cell lines, even in a coculture environment with healthy cells and (ii) the beta-amyloid peptide 1-42 (Abeta(1-42)), believed to be the most representative and toxic species in AD, both under its monomeric and fibrillar forms.	Curcumin	123-131	amyloid beta precursor protein	Homo sapiens	334-359
22538404-10	2012	PD98059, a mitogen extracellular kinase 1/2 inhibitor, and curcumin, an Egr1 inhibitor, blocked the arachidonic acid-mediated upregulation of TNFalpha in Kupffer cells.	Curcumin	59-67	tumor necrosis factor	Rattus norvegicus	142-150
22300367-6	2012	KEY RESULTS Curcumin was a potent hBCRP inhibitor in vitro (K(i) 0.70 +- 0.41 microM).	Curcumin	12-20	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	34-39
22561298-5	2012	Both salusin-beta-induced VCAM-1 induction and monocyte/HUVEC adhesion were suppressed by pharmacological inhibitors of NF-kappaB, e.g., Bay 11-7682 and curcumin.	Curcumin	153-161	torsin family 2 member A	Homo sapiens	5-17
22561298-5	2012	Both salusin-beta-induced VCAM-1 induction and monocyte/HUVEC adhesion were suppressed by pharmacological inhibitors of NF-kappaB, e.g., Bay 11-7682 and curcumin.	Curcumin	153-161	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-129
22300367-0	2012	Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP.	Curcumin	90-98	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	126-130
22300367-3	2012	EXPERIMENTAL APPROACH Effects of curcumin were measured on the ATP-dependent sulphasalazine uptake by hBCRP-expressing membrane vesicles and on oral bioavailability of sulphasalazine in wild-type and Bcrp(-/-) mice.	Curcumin	33-41	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	102-107
22300367-12	2012	CONCLUSIONS AND IMPLICATIONS Curcumin can be used to investigate effects of BCRP on oral bioavailability of drugs in humans.	Curcumin	29-37	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	76-80
22801507-5	2012	The aim of this study is to investigate whether the STAT3 inhibitor HO-3867, a novel curcumin analog, has a therapeutic effect on BRCA1-mutated ovarian cancer.	Curcumin	85-93	signal transducer and activator of transcription 3	Homo sapiens	52-57
22449710-3	2012	In this study, we observed a close connection between dephosphorylated Akt and an increase in phosphorylated heat shock protein 27 (HSP27) during combined treatment with curcumin and TRAIL.	Curcumin	170-178	AKT serine/threonine kinase 1	Homo sapiens	71-74
22548787-9	2012	Administration of pure curcumin or its water-soluble conjugate led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in eNOS, nNOS, HO-1, and Nrf2 genes, and a significant decrease in NF-Kbeta, p38, and iNOS genes.	Curcumin	23-31	NFE2 like bZIP transcription factor 2	Rattus norvegicus	211-215
22009290-7	2012	The addition of curcumin below the MIC diminished bacterial adherence onto both collagen- and fibronectin-coated glass surfaces and human tooth surfaces.	Curcumin	16-24	fibronectin 1	Homo sapiens	94-105
22009290-8	2012	It appears that the anti-adhesive effect of curcumin against S. mutans is mediated through collagen and fibronectin.	Curcumin	44-52	fibronectin 1	Homo sapiens	104-115
21130633-7	2012	The presence of curcumin with cypermethrin significantly decreased the blood biochemical markers and lipid peroxidation but significantly increased the reduced glutathione, catalase and glutathione peroxidase level and preserved the normal histological architecture of the liver, kidney and brain.	Curcumin	16-24	catalase	Rattus norvegicus	173-181
23087505-0	2012	Insulin catalyzes the curcumin-induced wound healing: an in vitro model for gingival repair.	Curcumin	22-30	insulin	Homo sapiens	0-7
22548787-9	2012	Administration of pure curcumin or its water-soluble conjugate led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in eNOS, nNOS, HO-1, and Nrf2 genes, and a significant decrease in NF-Kbeta, p38, and iNOS genes.	Curcumin	23-31	nitric oxide synthase 2	Rattus norvegicus	272-276
22552693-6	2012	Both p65 siRNA and curcumin mediated suppression of activation of the NF-kappaB signaling pathway via inhibition of the expression of p65 or IkappaBalpha phosphorylation in ESCC cell lines.	Curcumin	19-27	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	141-153
22562377-9	2012	KCP-4 cells were treated with a combination of cisplatin and curcumin, an inhibitor of NF-kappaB activation, and the cell viabilities were subsequently determined by the MTT assay using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide.	Curcumin	61-69	nuclear factor kappa B subunit 1	Homo sapiens	87-96
22562377-11	2012	Additionally, curcumin reduced the activation levels of NF-kappaB in KCP-4 cells, and suppressed the expression levels of Bcl-2, Bcl-xL and survivin, which are apoptosis-related proteins regulated by NF-kappaB.	Curcumin	14-22	nuclear factor kappa B subunit 1	Homo sapiens	200-209
22562377-11	2012	Additionally, curcumin reduced the activation levels of NF-kappaB in KCP-4 cells, and suppressed the expression levels of Bcl-2, Bcl-xL and survivin, which are apoptosis-related proteins regulated by NF-kappaB.	Curcumin	14-22	nuclear factor kappa B subunit 1	Homo sapiens	56-65
22562377-11	2012	Additionally, curcumin reduced the activation levels of NF-kappaB in KCP-4 cells, and suppressed the expression levels of Bcl-2, Bcl-xL and survivin, which are apoptosis-related proteins regulated by NF-kappaB.	Curcumin	14-22	BCL2 apoptosis regulator	Homo sapiens	122-127
22562377-11	2012	Additionally, curcumin reduced the activation levels of NF-kappaB in KCP-4 cells, and suppressed the expression levels of Bcl-2, Bcl-xL and survivin, which are apoptosis-related proteins regulated by NF-kappaB.	Curcumin	14-22	BCL2 like 1	Homo sapiens	129-135
22183741-0	2012	Curcumin attenuates TNF-alpha-induced expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and proinflammatory cytokines in human endometriotic stromal cells.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	20-29
23060694-9	2012	RESULTS: Curcumin increased ALP activity and osteoblast-specific mRNA expression of Runx2 and osteocalcin when rMSCs were cultured in osteogenic medium.	Curcumin	9-17	RUNX family transcription factor 2	Rattus norvegicus	84-89
23060694-9	2012	RESULTS: Curcumin increased ALP activity and osteoblast-specific mRNA expression of Runx2 and osteocalcin when rMSCs were cultured in osteogenic medium.	Curcumin	9-17	bone gamma-carboxyglutamate protein	Rattus norvegicus	94-105
22520056-11	2012	Also, curcumin caused down-regulation of the inflammatory cytokines TNF-alpha, IL-8, and MIF levels in the lung.	Curcumin	6-14	tumor necrosis factor	Rattus norvegicus	68-77
22520056-11	2012	Also, curcumin caused down-regulation of the inflammatory cytokines TNF-alpha, IL-8, and MIF levels in the lung.	Curcumin	6-14	macrophage migration inhibitory factor	Rattus norvegicus	89-92
22183741-0	2012	Curcumin attenuates TNF-alpha-induced expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and proinflammatory cytokines in human endometriotic stromal cells.	Curcumin	0-8	vascular cell adhesion molecule 1	Homo sapiens	87-120
22183741-5	2012	Endometriotic stromal cells treated with curcumin showed marked suppression of TNF-alpha-induced mRNA expression of ICAM-1 and VCAM-1.	Curcumin	41-49	tumor necrosis factor	Homo sapiens	79-88
22183741-5	2012	Endometriotic stromal cells treated with curcumin showed marked suppression of TNF-alpha-induced mRNA expression of ICAM-1 and VCAM-1.	Curcumin	41-49	vascular cell adhesion molecule 1	Homo sapiens	127-133
22183741-6	2012	Curcumin treatment also significantly decreased the TNF-alpha-induced cell surface and total protein expression of ICAM-1 and VCAM-1 in a dose-dependent manner.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	52-61
22183741-6	2012	Curcumin treatment also significantly decreased the TNF-alpha-induced cell surface and total protein expression of ICAM-1 and VCAM-1 in a dose-dependent manner.	Curcumin	0-8	vascular cell adhesion molecule 1	Homo sapiens	126-132
22183741-7	2012	In addition, treatment of endometriotic stromal cells with curcumin markedly inhibited TNF-alpha-induced secretion of IL-6, IL-8 and MCP-1.	Curcumin	59-67	tumor necrosis factor	Homo sapiens	87-96
22183741-7	2012	In addition, treatment of endometriotic stromal cells with curcumin markedly inhibited TNF-alpha-induced secretion of IL-6, IL-8 and MCP-1.	Curcumin	59-67	interleukin 6	Homo sapiens	118-122
22773343-3	2012	Our results using real time PCR, western blotting and immunostaining demonstrated that curcumin significantly increased the gene expression and protein levels of cardiac specific transcription factor NKx2.5, cardiac troponin I, myosin heavy chain, and endothelial nitric oxide synthase during ES cell differentiation.	Curcumin	87-95	NK2 homeobox 5	Homo sapiens	200-206
22183741-7	2012	In addition, treatment of endometriotic stromal cells with curcumin markedly inhibited TNF-alpha-induced secretion of IL-6, IL-8 and MCP-1.	Curcumin	59-67	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
22773343-4	2012	Furthermore, an NO donor enhanced the curcumin-mediated induction of NKx2.5 and other cardiac specific proteins.	Curcumin	38-46	NK2 homeobox 5	Homo sapiens	69-75
22183741-8	2012	Furthermore, curcumin inhibited the activation of transcription factor NF-kappaB, a key regulator of inflammation, in human endometriotic stromal cells.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	71-80
22591841-8	2012	The activity of CURCUMIN was also evidenced from the inhibition of macrophages proliferation (HBEGF), related to a strong down regulation of TNFalpha and to activation of fibrinolysis (SERPINE1).	Curcumin	16-24	heparin binding EGF like growth factor	Canis lupus familiaris	94-99
22690789-0	2012	The effect of curcumin on the stability of Abeta dimers.	Curcumin	14-22	amyloid beta precursor protein	Homo sapiens	43-48
22690789-4	2012	We observed that curcumin decreases the beta-sheet secondary structural content within the Abeta oligomers without reducing the contacts between the monomers.	Curcumin	17-25	amyloid beta precursor protein	Homo sapiens	91-96
22690789-6	2012	Furthermore, the pi-stacking interaction between curcumin (keto ring and enol ring) and the aromatic residues of Abeta, which exists throughout the simulations, has also contributed to the diminishing of the beta-sheet structure.	Curcumin	49-57	amyloid beta precursor protein	Homo sapiens	113-118
22690789-8	2012	We have examined the paths of curcumin on the Abeta proteins and determined the common routes where curcumin lingers as it traverses around the Abeta.	Curcumin	100-108	amyloid beta precursor protein	Homo sapiens	144-149
22690789-9	2012	In consequence, our study has provided a detailed interaction picture between curcumin and the Abeta oligomers.	Curcumin	78-86	amyloid beta precursor protein	Homo sapiens	95-100
22483553-0	2012	Curcumin reverses cis-platin resistance and promotes human lung adenocarcinoma A549/DDP cell apoptosis through HIF-1alpha and caspase-3 mechanisms.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-121
22483553-10	2012	Our findings shed light on drug resistant reversing effect of curcumin in lung cancer cells by inhibiting HIF-1alpha expression and activating caspase-3.	Curcumin	62-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
22483553-0	2012	Curcumin reverses cis-platin resistance and promotes human lung adenocarcinoma A549/DDP cell apoptosis through HIF-1alpha and caspase-3 mechanisms.	Curcumin	0-8	caspase 3	Homo sapiens	126-135
22483553-10	2012	Our findings shed light on drug resistant reversing effect of curcumin in lung cancer cells by inhibiting HIF-1alpha expression and activating caspase-3.	Curcumin	62-70	caspase 3	Homo sapiens	143-152
22483553-3	2012	Several pathways and specific targets including NF-kappaB, STAT3, COX-2, Akt and multidrug resistant protein have been identified to facilitate curcumin as a chemosensitizer.	Curcumin	144-152	nuclear factor kappa B subunit 1	Homo sapiens	48-57
22483553-3	2012	Several pathways and specific targets including NF-kappaB, STAT3, COX-2, Akt and multidrug resistant protein have been identified to facilitate curcumin as a chemosensitizer.	Curcumin	144-152	signal transducer and activator of transcription 3	Homo sapiens	59-64
22483553-3	2012	Several pathways and specific targets including NF-kappaB, STAT3, COX-2, Akt and multidrug resistant protein have been identified to facilitate curcumin as a chemosensitizer.	Curcumin	144-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	66-71
22483553-3	2012	Several pathways and specific targets including NF-kappaB, STAT3, COX-2, Akt and multidrug resistant protein have been identified to facilitate curcumin as a chemosensitizer.	Curcumin	144-152	AKT serine/threonine kinase 1	Homo sapiens	73-76
22483553-5	2012	To investigate the mechanism basis of curcumin as a chemosensitizer in lung cancer, we examined curcumin"s effects on HIF-1alpha in cis-platin (DDP) sensitive A549 and resistant A549/DDP cell lines by RT-PCR and Western blot.	Curcumin	96-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	118-128
22483553-8	2012	Combined curcumin and DDP treatment markedly inhibited A549/DDP cells proliferation, reversed DDP resistance and triggered apoptotic death by promoting HIF-1alpha degradation and activating caspase-3, respectively.	Curcumin	9-17	caspase 3	Homo sapiens	190-199
22483553-9	2012	Expression of HIF-1alpha-dependent P-gp also seemed to decrease as response to curcumin in a dose-dependent manner.	Curcumin	79-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-24
22450660-4	2012	In contrast to amino acid neurotransmitters, catecholamine neurotransmitters, L-DOPA, and curcumin prevent significant iron-mediated DNA damage (IC(50) values of 3.2 to 18 muM) and are electrochemically active.	Curcumin	90-98	latexin	Homo sapiens	172-175
22366645-8	2012	RESULTS: Acupuncture combined with curcumin potently protected the liver from CCl(4)-induced injury and fibrogenesis, as indicated by reduced levels of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, hyaluronic acid, laminin and procollagen III.	Curcumin	35-43	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	158-184
22469857-0	2012	The effect of the NF-kappa B inhibitors curcumin and lactacystin on myogenic differentiation of rhabdomyosarcoma cells.	Curcumin	40-48	nuclear factor kappa B subunit 1	Homo sapiens	18-28
22398366-0	2012	Study on effect of lipophilic curcumin on sub-domain IIA site of human serum albumin during unfolded and refolded states: a synchronous fluorescence spectroscopic study.	Curcumin	30-38	albumin	Homo sapiens	71-84
22398366-1	2012	Curcumin having pharmaceutical application as anti-oxidant, anti-inflammatory and anti-carcinogenic drug necessitates studying interaction of this molecule with native, unfolded and refolded state of human serum albumin (HSA), carrier protein in the blood.	Curcumin	0-8	albumin	Homo sapiens	206-219
22522053-8	2012	In addition, p53 involved in curcumin-mediated Fas, FasL, and DR5 expression and cell apoptosis in chondrosarcoma cells.	Curcumin	29-37	tumor protein p53	Homo sapiens	13-16
21932059-0	2012	ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells.	Curcumin	56-64	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
21932059-0	2012	ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells.	Curcumin	56-64	mitogen-activated protein kinase 1	Homo sapiens	73-76
21932059-0	2012	ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells.	Curcumin	56-64	mitogen-activated protein kinase 1	Homo sapiens	81-84
21932059-5	2012	Pretreatment with curcumin dose-dependently decreased DEHP-induced expression of ICAM-1 and IL-8 as well as phosphorylation of ERK1/2 and p38.	Curcumin	18-26	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
21932059-5	2012	Pretreatment with curcumin dose-dependently decreased DEHP-induced expression of ICAM-1 and IL-8 as well as phosphorylation of ERK1/2 and p38.	Curcumin	18-26	mitogen-activated protein kinase 3	Homo sapiens	127-133
21932059-5	2012	Pretreatment with curcumin dose-dependently decreased DEHP-induced expression of ICAM-1 and IL-8 as well as phosphorylation of ERK1/2 and p38.	Curcumin	18-26	mitogen-activated protein kinase 1	Homo sapiens	138-141
21932059-7	2012	We suggest that curcumin inhibits DEHP-induced expression of ICAM-1 and IL-8 through ERK and p38 MAPK signaling pathways in HUVECs and may contribute to ameliorate pathologies of DEHP-related allergic disorders.	Curcumin	16-24	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
21932059-7	2012	We suggest that curcumin inhibits DEHP-induced expression of ICAM-1 and IL-8 through ERK and p38 MAPK signaling pathways in HUVECs and may contribute to ameliorate pathologies of DEHP-related allergic disorders.	Curcumin	16-24	mitogen-activated protein kinase 1	Homo sapiens	85-88
21932059-7	2012	We suggest that curcumin inhibits DEHP-induced expression of ICAM-1 and IL-8 through ERK and p38 MAPK signaling pathways in HUVECs and may contribute to ameliorate pathologies of DEHP-related allergic disorders.	Curcumin	16-24	mitogen-activated protein kinase 1	Homo sapiens	93-96
21932059-7	2012	We suggest that curcumin inhibits DEHP-induced expression of ICAM-1 and IL-8 through ERK and p38 MAPK signaling pathways in HUVECs and may contribute to ameliorate pathologies of DEHP-related allergic disorders.	Curcumin	16-24	mitogen-activated protein kinase 3	Homo sapiens	97-101
22521131-0	2012	Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling.	Curcumin	0-8	notch receptor 1	Homo sapiens	91-98
22521131-7	2012	We also found that specific downregulation of Notch-1 via small-interfering RNA prior to curcumin treatment resulted in enhanced inhibition of cell growth and invasion.	Curcumin	89-97	notch receptor 1	Homo sapiens	46-53
22521131-8	2012	These results suggest that antitumor activity of curcumin is mediated through a novel mechanism involving inactivation of the Notch-1 signaling pathway.	Curcumin	49-57	notch receptor 1	Homo sapiens	126-133
22521131-9	2012	Our data provide the first evidence that the downregulation of Notch-1 by curcumin may be an effective approach for the treatment of osteosarcoma.	Curcumin	74-82	notch receptor 1	Homo sapiens	63-70
22469952-7	2012	Curcumin (20 microM), bleomycin (400 microg/ml) and H2O2 (400 microM) incubation for 24 h decreased the viability of NTera-2 cells, and increased caspase-3, -8 and -9 activities, Bax and cytoplasmic cytochrome c levels and decreased Bcl-2 levels.	Curcumin	0-8	caspase 3	Homo sapiens	146-166
22498762-5	2012	In the present study, we investigated the effect of curcumin on apoptosis induction in TNF-alpha-treated HaCaT cells.	Curcumin	52-60	tumor necrosis factor	Homo sapiens	87-96
22498762-6	2012	These results show that curcumin exhibited a significant pro-apoptotic effect on HaCaT cells only in the presence of TNF-alpha and/or TRAIL.	Curcumin	24-32	tumor necrosis factor	Homo sapiens	117-126
22498762-6	2012	These results show that curcumin exhibited a significant pro-apoptotic effect on HaCaT cells only in the presence of TNF-alpha and/or TRAIL.	Curcumin	24-32	TNF superfamily member 10	Homo sapiens	134-139
22498762-9	2012	In addition, the expression of anti-apoptotic proteins (IAP1, IAP2, Bcl-X(L)) was up-regulated by TNF-alpha but suppressed by curcumin in HaCaT cells.	Curcumin	126-134	BCL2 like 1	Homo sapiens	68-76
22498762-11	2012	As expected, curcumin inhibited TNF-alpha-induced activation of NF-kappaB, including NF-kappaB-P65.	Curcumin	13-21	tumor necrosis factor	Homo sapiens	32-41
22498762-12	2012	Curcumin also inhibited the TNF-alpha-induced production of IL-6/IL-8 in HaCaT cells.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	28-37
22498762-12	2012	Curcumin also inhibited the TNF-alpha-induced production of IL-6/IL-8 in HaCaT cells.	Curcumin	0-8	interleukin 6	Homo sapiens	60-64
22498762-12	2012	Curcumin also inhibited the TNF-alpha-induced production of IL-6/IL-8 in HaCaT cells.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
22498762-13	2012	These results imply that curcumin-induced apoptosis of HaCaT cells only occurs when TNF-alpha or/and TRAIL are present.	Curcumin	25-33	tumor necrosis factor	Homo sapiens	84-93
22498762-13	2012	These results imply that curcumin-induced apoptosis of HaCaT cells only occurs when TNF-alpha or/and TRAIL are present.	Curcumin	25-33	TNF superfamily member 10	Homo sapiens	101-106
22498762-14	2012	Therefore, we believe that curcumin is able to reverse the anti-apoptotic function of TNF-alpha in HaCaT cells and thus expect curcumin to be successful in the treatment of psoriasis.	Curcumin	27-35	tumor necrosis factor	Homo sapiens	86-95
22498762-14	2012	Therefore, we believe that curcumin is able to reverse the anti-apoptotic function of TNF-alpha in HaCaT cells and thus expect curcumin to be successful in the treatment of psoriasis.	Curcumin	127-135	tumor necrosis factor	Homo sapiens	86-95
22613224-7	2012	Inhibition of autophagy, due to the diminished expression of ATG5 by RNAi decreased the number of senescent cells induced by curcumin, but did not lead to increased cell death.	Curcumin	125-133	autophagy related 5	Homo sapiens	61-65
21775121-7	2012	In U138MG and C6 cells, curcumin decreased the constitutive activation of PI3K/Akt and NFkappaB survival pathways, down-regulated the antiapoptotic NFkappaB-regulated protein bcl-xl and induced mitochondrial dysfunction as a prelude to apoptosis.	Curcumin	24-32	AKT serine/threonine kinase 1	Homo sapiens	79-82
21775121-7	2012	In U138MG and C6 cells, curcumin decreased the constitutive activation of PI3K/Akt and NFkappaB survival pathways, down-regulated the antiapoptotic NFkappaB-regulated protein bcl-xl and induced mitochondrial dysfunction as a prelude to apoptosis.	Curcumin	24-32	nuclear factor kappa B subunit 1	Homo sapiens	87-95
21775121-7	2012	In U138MG and C6 cells, curcumin decreased the constitutive activation of PI3K/Akt and NFkappaB survival pathways, down-regulated the antiapoptotic NFkappaB-regulated protein bcl-xl and induced mitochondrial dysfunction as a prelude to apoptosis.	Curcumin	24-32	nuclear factor kappa B subunit 1	Homo sapiens	148-156
21775121-7	2012	In U138MG and C6 cells, curcumin decreased the constitutive activation of PI3K/Akt and NFkappaB survival pathways, down-regulated the antiapoptotic NFkappaB-regulated protein bcl-xl and induced mitochondrial dysfunction as a prelude to apoptosis.	Curcumin	24-32	BCL2 like 1	Homo sapiens	175-181
22469952-8	2012	The concurrent use of curcumin with bleomycin induced caspase-3, -8 and -9 activities to a greater extent in NTera-2 cells than the use of each drug alone.	Curcumin	22-30	caspase 3	Homo sapiens	54-74
22469952-7	2012	Curcumin (20 microM), bleomycin (400 microg/ml) and H2O2 (400 microM) incubation for 24 h decreased the viability of NTera-2 cells, and increased caspase-3, -8 and -9 activities, Bax and cytoplasmic cytochrome c levels and decreased Bcl-2 levels.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	179-182
22469952-7	2012	Curcumin (20 microM), bleomycin (400 microg/ml) and H2O2 (400 microM) incubation for 24 h decreased the viability of NTera-2 cells, and increased caspase-3, -8 and -9 activities, Bax and cytoplasmic cytochrome c levels and decreased Bcl-2 levels.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	199-211
22469952-7	2012	Curcumin (20 microM), bleomycin (400 microg/ml) and H2O2 (400 microM) incubation for 24 h decreased the viability of NTera-2 cells, and increased caspase-3, -8 and -9 activities, Bax and cytoplasmic cytochrome c levels and decreased Bcl-2 levels.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	233-238
22475723-8	2012	Further bioinformatic analysis shows that proteins modulated by curcumin are implicated in protein folding (such as heat-shock protein PPP2R1A; RNA splicing proteins RBM17, DDX39; cell death proteins HMGB1 and NPM1; proteins involved in androgen receptor signaling, NPM1 and FKBP4/FKBP52), and that this compound could have an impact on miR-141, miR-152, and miR-183 expression.	Curcumin	64-72	RNA binding motif protein 17	Homo sapiens	166-171
22475723-8	2012	Further bioinformatic analysis shows that proteins modulated by curcumin are implicated in protein folding (such as heat-shock protein PPP2R1A; RNA splicing proteins RBM17, DDX39; cell death proteins HMGB1 and NPM1; proteins involved in androgen receptor signaling, NPM1 and FKBP4/FKBP52), and that this compound could have an impact on miR-141, miR-152, and miR-183 expression.	Curcumin	64-72	DExD-box helicase 39A	Homo sapiens	173-178
22475723-8	2012	Further bioinformatic analysis shows that proteins modulated by curcumin are implicated in protein folding (such as heat-shock protein PPP2R1A; RNA splicing proteins RBM17, DDX39; cell death proteins HMGB1 and NPM1; proteins involved in androgen receptor signaling, NPM1 and FKBP4/FKBP52), and that this compound could have an impact on miR-141, miR-152, and miR-183 expression.	Curcumin	64-72	FKBP prolyl isomerase 4	Homo sapiens	275-280
22475723-8	2012	Further bioinformatic analysis shows that proteins modulated by curcumin are implicated in protein folding (such as heat-shock protein PPP2R1A; RNA splicing proteins RBM17, DDX39; cell death proteins HMGB1 and NPM1; proteins involved in androgen receptor signaling, NPM1 and FKBP4/FKBP52), and that this compound could have an impact on miR-141, miR-152, and miR-183 expression.	Curcumin	64-72	FKBP prolyl isomerase 4	Homo sapiens	281-287
22475723-8	2012	Further bioinformatic analysis shows that proteins modulated by curcumin are implicated in protein folding (such as heat-shock protein PPP2R1A; RNA splicing proteins RBM17, DDX39; cell death proteins HMGB1 and NPM1; proteins involved in androgen receptor signaling, NPM1 and FKBP4/FKBP52), and that this compound could have an impact on miR-141, miR-152, and miR-183 expression.	Curcumin	64-72	microRNA 141	Homo sapiens	337-344
22475723-8	2012	Further bioinformatic analysis shows that proteins modulated by curcumin are implicated in protein folding (such as heat-shock protein PPP2R1A; RNA splicing proteins RBM17, DDX39; cell death proteins HMGB1 and NPM1; proteins involved in androgen receptor signaling, NPM1 and FKBP4/FKBP52), and that this compound could have an impact on miR-141, miR-152, and miR-183 expression.	Curcumin	64-72	microRNA 183	Homo sapiens	359-366
22645638-0	2012	Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	20-24
22645638-10	2012	Curcumin intervention dramatically reversed these defects in Nrf2 signaling.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	61-65
22645638-12	2012	CONCLUSION: These findings suggest that the short-term treatment of curcumin in HFD-fed mice effectively ameliorates muscular oxidative stress by activating Nrf2 function that is a novel mechanism for its effect in improving glucose intolerance.	Curcumin	68-76	nuclear factor, erythroid derived 2, like 2	Mus musculus	157-161
26434261-6	2012	A decrease in expression of Bcl-2 and the cleavage of poly ADP-ribose polymerase (PARP) were observed after exposure to curcumin.	Curcumin	120-128	BCL2 apoptosis regulator	Homo sapiens	28-33
22622204-6	2012	Curcumin can also reverse FOXO1 (a mediator of autophagy) nuclear localization along with causing an elevated level of cytoplasmic acetylation of FOXO1 and the interaction of acetylated FOXO1 and ATG7, under the circumstance of oxidative stress.	Curcumin	0-8	forkhead box O1	Homo sapiens	26-31
22622204-6	2012	Curcumin can also reverse FOXO1 (a mediator of autophagy) nuclear localization along with causing an elevated level of cytoplasmic acetylation of FOXO1 and the interaction of acetylated FOXO1 and ATG7, under the circumstance of oxidative stress.	Curcumin	0-8	forkhead box O1	Homo sapiens	146-151
22622204-6	2012	Curcumin can also reverse FOXO1 (a mediator of autophagy) nuclear localization along with causing an elevated level of cytoplasmic acetylation of FOXO1 and the interaction of acetylated FOXO1 and ATG7, under the circumstance of oxidative stress.	Curcumin	0-8	forkhead box O1	Homo sapiens	146-151
22622204-7	2012	Additionally, knockdown of FOXO1 by shRNA inhibits not only the protective effects that curcumin induced, but the autophagic process, from the quantity of LC3-II to the expression of RAB7.	Curcumin	88-96	forkhead box O1	Homo sapiens	27-32
21745189-3	2012	EXPERIMENTAL APPROACH: We utilized liposomal incorporation of a potent inhibitor of the NF-kappaB pathway, curcumin, to target delivery to renal tubular epithelial and antigen-presenting cells.	Curcumin	107-115	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-97
21745189-8	2012	KEY RESULTS: Liposomal curcumin significantly improved serum creatinine, reduced histological injury and cellular apoptosis and lowered Toll-like receptor-4, heat shock protein-70 and TNF-alpha mRNA expression.	Curcumin	23-31	toll-like receptor 4	Mus musculus	136-156
21745189-8	2012	KEY RESULTS: Liposomal curcumin significantly improved serum creatinine, reduced histological injury and cellular apoptosis and lowered Toll-like receptor-4, heat shock protein-70 and TNF-alpha mRNA expression.	Curcumin	23-31	tumor necrosis factor	Mus musculus	184-193
21745189-11	2012	These actions of curcumin were mediated by inhibition of NF-kappaB, MAPK and phospho-S6 ribosomal protein.	Curcumin	17-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-66
22510010-9	2012	miR-22, a tumor-suppressor miRNA was one of the miRNA which was upregulated by curcumin.	Curcumin	79-87	microRNA 22	Homo sapiens	0-6
26434261-6	2012	A decrease in expression of Bcl-2 and the cleavage of poly ADP-ribose polymerase (PARP) were observed after exposure to curcumin.	Curcumin	120-128	poly(ADP-ribose) polymerase 1	Homo sapiens	54-80
26434261-6	2012	A decrease in expression of Bcl-2 and the cleavage of poly ADP-ribose polymerase (PARP) were observed after exposure to curcumin.	Curcumin	120-128	poly(ADP-ribose) polymerase 1	Homo sapiens	82-86
22237476-6	2012	Furthermore, LPS-induced nuclear factor-kappaB (NF-kappaB) activation and tumor necrosis factor-alpha (TNF-alpha) release from HUVECs were inhibited by curcumin and BDMC.	Curcumin	152-160	tumor necrosis factor	Homo sapiens	74-101
22387197-8	2012	Curcumin treatment of leukemic cells also downregulates the expression of the inhibitor of apoptosis proteins (IAPs), phospho-Akt, c-Myc, and cyclin D1.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	126-129
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	19-27	catalase	Mus musculus	240-243
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	32-40	catalase	Mus musculus	240-243
22237476-6	2012	Furthermore, LPS-induced nuclear factor-kappaB (NF-kappaB) activation and tumor necrosis factor-alpha (TNF-alpha) release from HUVECs were inhibited by curcumin and BDMC.	Curcumin	152-160	tumor necrosis factor	Homo sapiens	103-112
21324484-10	2012	Curcumin had effective inhibitory effects on the expression of TLR4, MyD88, and NF-kappaB in lung tissues 24 h post-CPB (P &lt; 0.05 versus vehicle group).	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	63-67
21324484-13	2012	This anti-inflammatory effect of curcumin is partly related to the inhibition of TLR4, MyD88, and NF-kappaB.	Curcumin	33-41	toll-like receptor 4	Rattus norvegicus	81-85
22588934-0	2012	[Effects of curcumin on syndecan-4 protein and p44/42 mitogen-activated protein kinase expression in tumor necrosis factor-alpha-induced rat vascular smooth muscle cells in vitro].	Curcumin	12-20	tumor necrosis factor	Rattus norvegicus	101-128
22648616-6	2012	Furthermore, the curcumin-induced upregulation of ABCA1 was mainly through calmodulin-liver X receptor alpha (LXRalpha)-dependent transcriptional regulation.	Curcumin	17-25	nuclear receptor subfamily 1, group H, member 3	Mus musculus	110-118
22648616-7	2012	Curcumin administration modulated the expression of SR-A, ABCA1, ABCG1, and SR-BI in aortas and retarded atherosclerosis in apoE-/- mice.	Curcumin	0-8	apolipoprotein E	Mus musculus	124-128
22588934-5	2012	Curcumin treatment did not obviously affect the growth of otherwise untreated VSMCs(P&gt;0.05), but could significantly suppress TNF-alpha-induced proliferation of VSMCs (P/0.01).	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	129-138
22588934-6	2012	TNF-alpha treatment also significantly increased the expression of syndecan-4 protein and phosphorylated p44/42 MAPK (P&lt;0.01), which was markedly lowered by treatment with curcumin (P/0.01).	Curcumin	175-183	tumor necrosis factor	Rattus norvegicus	0-9
22588934-8	2012	CONCLUSION: Curcumin can suppress the proliferation of rat VSMCs and lower the expression of syndecan-4 protein and phosphorylated p44/42 MAPK in TNF-alpha-induced VSMCs.	Curcumin	12-20	tumor necrosis factor	Rattus norvegicus	146-155
22558987-0	2012	[Protective effect and mechanism of curcumin on ActD/TNF-alpha-induced synergistically apoptosis in PC12 cells].	Curcumin	36-44	tumor necrosis factor	Rattus norvegicus	53-62
22311129-0	2012	The CB1 receptor-mediated endocannabinoid signaling and NGF: the novel targets of curcumin.	Curcumin	82-90	cannabinoid receptor 1	Homo sapiens	4-7
22311129-0	2012	The CB1 receptor-mediated endocannabinoid signaling and NGF: the novel targets of curcumin.	Curcumin	82-90	nerve growth factor	Homo sapiens	56-59
22311129-3	2012	Based on the interaction between the neurotrophins and endocannabinoid system as well as their contribution to the emotional reactivity and antidepressant action, here we show that 4-week treatment with curcumin, similar to the classical antidepressant amitriptyline, results in the sustained elevation of brain nerve growth factor (NGF) and endocannabinoids in dose-dependent and brain region-specific fashion.	Curcumin	203-211	nerve growth factor	Homo sapiens	312-331
22311129-3	2012	Based on the interaction between the neurotrophins and endocannabinoid system as well as their contribution to the emotional reactivity and antidepressant action, here we show that 4-week treatment with curcumin, similar to the classical antidepressant amitriptyline, results in the sustained elevation of brain nerve growth factor (NGF) and endocannabinoids in dose-dependent and brain region-specific fashion.	Curcumin	203-211	nerve growth factor	Homo sapiens	333-336
22311129-6	2012	Our findings by presenting the CB(1) receptor-mediated endocannabinoid signaling and NGF as novel targets for curcumin, suggest that more attention should be focused on the therapeutic potential of herbal medicines including curcumin.	Curcumin	110-118	nerve growth factor	Homo sapiens	85-88
21796654-0	2012	The curcumin analog ca27 down-regulates androgen receptor through an oxidative stress mediated mechanism in human prostate cancer cells.	Curcumin	4-12	androgen receptor	Homo sapiens	40-57
21796654-4	2012	We show here that the curcumin analog 27 (ca27) down-regulates AR expression in several prostate cancer cell lines.	Curcumin	22-30	androgen receptor	Homo sapiens	63-65
22284765-2	2012	We sought to evaluate the effects of curcumin, an inhibitor of NF-kappaB, on a xenograft model of disseminated neuroblastoma.	Curcumin	37-45	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	63-72
22284765-5	2012	RESULTS: Curcumin suppressed NF-kappaB activation and proliferation of all neuroblastoma cell lines in vitro.	Curcumin	9-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	29-38
22284765-7	2012	Curcumin-treated tumors had decreased NF-kappaB activity and an associated significant decrease in tumor cell proliferation and an increase in tumor cell apoptosis, as well as a decrease in tumor vascular endothelial growth factor levels and microvessel density.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	38-47
22284765-8	2012	CONCLUSION: Liposomal curcumin suppressed neuroblastoma growth, with treated tumors showing a decrease in NF-kappaB activity.	Curcumin	22-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	106-115
22284765-9	2012	Our results suggest that liposomal curcumin may be a viable option for the treatment of neuroblastoma that works via inhibiting the NF-kappaB pathway.	Curcumin	35-43	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	132-141
22558987-1	2012	AIM: To investigate the protective effect and mechanism of curcumin against ActD/TNF-alpha-induced synergistically apoptosis in PC12 cells.	Curcumin	59-67	tumor necrosis factor	Rattus norvegicus	81-90
22558987-4	2012	After treating with curcumin(5 mumol/L), survival of PC12 cells was increased(P&lt;0.05), the number of cells with pyknosis and karyorrhexis was reduced, MMP and expression of Bcl-2 were increased(P&lt;0.05).	Curcumin	20-28	BCL2, apoptosis regulator	Rattus norvegicus	176-181
22558987-5	2012	CONCLUSION: Curcumin can resist the ActD/TNF-alpha-induced synergistically apoptosis in PC12 cells, the mechanisms of which may be related to an increase in MMP and Bcl-2 expression.	Curcumin	12-20	tumor necrosis factor	Rattus norvegicus	41-50
22558987-5	2012	CONCLUSION: Curcumin can resist the ActD/TNF-alpha-induced synergistically apoptosis in PC12 cells, the mechanisms of which may be related to an increase in MMP and Bcl-2 expression.	Curcumin	12-20	BCL2, apoptosis regulator	Rattus norvegicus	165-170
22475209-5	2012	RESULTS: KI mice fed a curcumin-containing diet since conception showed decreased huntingtin aggregates and increased striatal DARPP-32 and D1 receptor mRNAs, as well as an amelioration of rearing deficits.	Curcumin	23-31	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	127-135
22509079-10	2012	Pretreatment with curcumin significantly decreased the elevation of ICAM-1 and TNF-alpha levels compared to treatment with indomethacin alone (413.66 +- 147.74 pg/mL vs 1106.50 +- 504.22 pg/mL, P = 0.019 and 58.27 +- 67.74 pg/mL vs 230.92 +- 114.47 pg/mL, P = 0.013 respectively).	Curcumin	18-26	tumor necrosis factor	Rattus norvegicus	79-88
22509079-15	2012	CONCLUSION: The results indicate that curcumin prevents indomethacin-induced gastropathy through the improvement of gastric microcirculation by attenuating the level of ICAM-1 and TNF-alpha.	Curcumin	38-46	tumor necrosis factor	Rattus norvegicus	180-189
21831045-0	2012	Anti-carcinogenic action of curcumin by activation of antioxidant defence system and inhibition of NF-kappaB signalling in lymphoma-bearing mice.	Curcumin	28-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
21831045-8	2012	The study highlights the anti-carcinogenic role of curcumin by modulation of NF-kappaB activation and oxidative stress via the endogenous antioxidant defence system.	Curcumin	51-59	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	77-86
21831045-12	2012	Curcumin inhibits oxidative state in the liver of lymphoma-bearing mice by enhancing the transcription and activities of antioxidant enzymes, which in turn modulate activation of NF-kappaB, leading to a decrease in lymphoma growth.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	179-188
22484638-9	2012	RESULTS: In vitro, curcumin (50 muM) significantly abrogated DNA damage and NF-kappaB activity induced by bile.	Curcumin	19-27	latexin	Homo sapiens	32-35
22298641-1	2012	Curcumin can induce p53-independent apoptosis.	Curcumin	0-8	tumor protein p53	Homo sapiens	20-23
22298641-3	2012	Here, we show that curcumin-induced apoptosis in a panel of tumor cells with mutant p53.	Curcumin	19-27	tumor protein p53	Homo sapiens	84-87
22298641-4	2012	Curcumin rapidly induced activation of the mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal kinase (JNK).	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	95-136
22298641-4	2012	Curcumin rapidly induced activation of the mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal kinase (JNK).	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	138-144
22298641-4	2012	Curcumin rapidly induced activation of the mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal kinase (JNK).	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	150-173
22298641-4	2012	Curcumin rapidly induced activation of the mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase 1/2 (Erk1/2) and c-Jun N-terminal kinase (JNK).	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	175-178
22298641-5	2012	Inhibition of JNK (with SP600125) or Erk1/2 (with U0126) partially prevented curcumin-induced cell death in the cells.	Curcumin	77-85	mitogen-activated protein kinase 8	Homo sapiens	14-17
22298641-5	2012	Inhibition of JNK (with SP600125) or Erk1/2 (with U0126) partially prevented curcumin-induced cell death in the cells.	Curcumin	77-85	mitogen-activated protein kinase 3	Homo sapiens	37-43
22298641-6	2012	Similarly, expression of dominant negative c-Jun or downregulation of Erk1/2 in part attenuated curcumin-induced cell death.	Curcumin	96-104	mitogen-activated protein kinase 3	Homo sapiens	70-76
22298641-8	2012	Furthermore, we found that curcumin-induced activation of MAPK pathways was related to inhibition of the serine/threonine protein phosphatases 2A (PP2A) and 5 (PP5).	Curcumin	27-35	mitogen-activated protein kinase 3	Homo sapiens	58-62
22298641-9	2012	Overexpression of PP2A or PP5 partially prevented curcumin-induced activation of JNK and Erk1/2 phosphorylation as well as cell death.	Curcumin	50-58	mitogen-activated protein kinase 8	Homo sapiens	81-84
22298641-9	2012	Overexpression of PP2A or PP5 partially prevented curcumin-induced activation of JNK and Erk1/2 phosphorylation as well as cell death.	Curcumin	50-58	mitogen-activated protein kinase 3	Homo sapiens	89-95
22298641-10	2012	The results suggest that curcumin induction of ROS activates MAPKs, at least partially by inhibiting PP2A and PP5, thereby leading to p53-independent apoptosis in tumor cells.	Curcumin	25-33	tumor protein p53	Homo sapiens	134-137
22484638-10	2012	Pretreating OE33 cells with curcumin (50 muM) completely abolished the ability of DCA (300 muM) to activate NF-kappaB.	Curcumin	28-36	latexin	Homo sapiens	41-44
22484638-10	2012	Pretreating OE33 cells with curcumin (50 muM) completely abolished the ability of DCA (300 muM) to activate NF-kappaB.	Curcumin	28-36	latexin	Homo sapiens	91-94
22484638-11	2012	In vivo, IL-8 expression was non-significantly suppressed in the curcumin-supplemented patients compared to the squamous control tissue, whilst also showing a doubling in the apoptotic frequency compared to non-supplemented control patients.	Curcumin	65-73	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
22179587-0	2012	The curcumin analogue hydrazinocurcumin exhibits potent suppressive             activity on carcinogenicity of breast cancer cells via STAT3 inhibition.	Curcumin	4-12	signal transducer and activator of transcription 3	Homo sapiens	135-140
22696871-4	2012	Curcumin has been reported as having a neural protective effect on the AD model, and could modulate the proliferation of tumor cells through the regulation of cyclin D1 and c-myc cell signaling pathways.	Curcumin	0-8	cyclin D1	Rattus norvegicus	159-168
22696871-9	2012	Furthermore, treatment with curcumin could inhibit abnormal activated cyclin D1 protein level, and decrease the Brdu positive cells in proportion to the Abeta25-35 treatment neurons.	Curcumin	28-36	cyclin D1	Rattus norvegicus	70-79
22179587-3	2012	The results demonstrated that compared to curcumin, HC             was more effective in inhibiting STAT3 phosphorylation and downregulation of an             array of STAT3 downstream targets which contributed to suppression of cell proliferation,             loss of colony formation, depression of cell migration and invasion as well as             induction of cell apoptosis.	Curcumin	42-50	signal transducer and activator of transcription 3	Homo sapiens	100-105
22179587-3	2012	The results demonstrated that compared to curcumin, HC             was more effective in inhibiting STAT3 phosphorylation and downregulation of an             array of STAT3 downstream targets which contributed to suppression of cell proliferation,             loss of colony formation, depression of cell migration and invasion as well as             induction of cell apoptosis.	Curcumin	42-50	signal transducer and activator of transcription 3	Homo sapiens	168-173
22443687-0	2012	Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK pathways.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	93-96
22443687-9	2012	Inhibitor of JNK and ERK reduced the pro-apoptotic effect of curcumin on THP-1 cells as evidenced by caspase activity and the activation of ERK/JNK/Jun cascades.	Curcumin	61-69	mitogen-activated protein kinase 8	Homo sapiens	13-16
21947854-0	2012	Curcumin inhibits metastatic progression of breast cancer cell through suppression of urokinase-type plasminogen activator by NF-kappa B signaling pathways.	Curcumin	0-8	plasminogen activator, urokinase	Homo sapiens	86-122
21947854-7	2012	Western blot was performed to detect the effect of curcumin on the expression of uPA.	Curcumin	51-59	plasminogen activator, urokinase	Homo sapiens	81-84
21947854-10	2012	Curcumin also significantly decreased (P &lt; 0.05) the expression of uPA and NF-kappaB DNA binding activity, respectively.	Curcumin	0-8	plasminogen activator, urokinase	Homo sapiens	70-73
21947854-10	2012	Curcumin also significantly decreased (P &lt; 0.05) the expression of uPA and NF-kappaB DNA binding activity, respectively.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	78-87
21947854-11	2012	It is concluded that curcumin inhibits the adhesion and invasion of MCF-7 cells through down-regulating the protein expression of uPA via of NF-kappaB activation.	Curcumin	21-29	plasminogen activator, urokinase	Homo sapiens	130-133
21947854-11	2012	It is concluded that curcumin inhibits the adhesion and invasion of MCF-7 cells through down-regulating the protein expression of uPA via of NF-kappaB activation.	Curcumin	21-29	nuclear factor kappa B subunit 1	Homo sapiens	141-150
22315092-3	2012	Shotgun analysis demonstrated that 66 proteins were differentially expressed in response to 24 h treatment with 40 muM curcumin in sensitive cells, whereas 32 proteins were significantly modulated in treated resistant cells.	Curcumin	119-127	latexin	Homo sapiens	115-118
22449094-0	2012	Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells.	Curcumin	5-13	WT1 transcription factor	Homo sapiens	42-45
22449094-1	2012	BACKGROUND: Pure curcumin has been reported to down-regulate the expression of WT1 in leukemic cells.	Curcumin	17-25	WT1 transcription factor	Homo sapiens	79-82
22449094-2	2012	However, the molecular mechanism underlying the down-regulation of WT1 by curcumin is not completely delineated.	Curcumin	74-82	WT1 transcription factor	Homo sapiens	67-70
22449094-4	2012	METHODS: K562 and HL-60 cells were treated with different concentrations of curcumin for 24 and 48 hours, the level of miR-15a/16-1 and WT1 were detected by qRT-PCR and Western blotting.	Curcumin	76-84	WT1 transcription factor	Homo sapiens	119-139
22449094-6	2012	RESULTS: We found that pure curcumin upregulated the expression of miR-15a/16-1 and downregulated the expression of WT1 in leukemic cells and primary acute myeloid leukemia (AML) cells.	Curcumin	28-36	WT1 transcription factor	Homo sapiens	116-119
22449094-8	2012	These results reveal that curcumin induced-upregulation of miR-15a/16-1 is an early event upstream to downregulation of WT1.	Curcumin	26-34	WT1 transcription factor	Homo sapiens	120-123
22449094-9	2012	Furthermore, anti-miR-15a/16-1 oligonucleotides (AMO) partly reversed the downregulation of WT1 induced by pure curcumin in leukemic cells and AMO promoted the growth of curcumin treated-K562 and HL-60 cells.	Curcumin	112-120	WT1 transcription factor	Homo sapiens	92-95
22449094-10	2012	CONCLUSION: Thus, these data suggest for the first time that pure curcumin downregulated the expression of WT1 partly by upregulating the expression of miR-15a/16-1 in leukemic cells.	Curcumin	66-74	WT1 transcription factor	Homo sapiens	107-110
22449094-11	2012	miR-15a/16-1 mediated WT1 downregulation plays an important role in the anti-proliferation effect of curcumin in leukemic cells.	Curcumin	101-109	WT1 transcription factor	Homo sapiens	22-25
22443687-9	2012	Inhibitor of JNK and ERK reduced the pro-apoptotic effect of curcumin on THP-1 cells as evidenced by caspase activity and the activation of ERK/JNK/Jun cascades.	Curcumin	61-69	mitogen-activated protein kinase 1	Homo sapiens	21-24
22443687-9	2012	Inhibitor of JNK and ERK reduced the pro-apoptotic effect of curcumin on THP-1 cells as evidenced by caspase activity and the activation of ERK/JNK/Jun cascades.	Curcumin	61-69	mitogen-activated protein kinase 1	Homo sapiens	140-143
22443687-9	2012	Inhibitor of JNK and ERK reduced the pro-apoptotic effect of curcumin on THP-1 cells as evidenced by caspase activity and the activation of ERK/JNK/Jun cascades.	Curcumin	61-69	mitogen-activated protein kinase 8	Homo sapiens	144-147
22443687-11	2012	CONCLUSIONS: This study demonstrates that curcumin can induce the THP-1 cell apoptosis through the activation of JNK/ERK/AP1 pathways.	Curcumin	42-50	mitogen-activated protein kinase 8	Homo sapiens	113-116
22443687-11	2012	CONCLUSIONS: This study demonstrates that curcumin can induce the THP-1 cell apoptosis through the activation of JNK/ERK/AP1 pathways.	Curcumin	42-50	mitogen-activated protein kinase 1	Homo sapiens	117-120
22443687-0	2012	Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK pathways.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	97-100
22443687-6	2012	MAPK inhibitors were used to further confirm the molecular mechanism of curcumin-induced THP-1 cell apoptosis.	Curcumin	72-80	mitogen-activated protein kinase 1	Homo sapiens	0-4
22443687-8	2012	Curcumin significantly increased the phosphorylation of ERK, JNK and their downstream molecules (c-Jun and Jun B).	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	56-59
22443687-8	2012	Curcumin significantly increased the phosphorylation of ERK, JNK and their downstream molecules (c-Jun and Jun B).	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	61-64
22227273-0	2012	Curcumin as anti-endometriotic agent: implication of MMP-3 and intrinsic apoptotic pathway.	Curcumin	0-8	matrix metallopeptidase 3	Homo sapiens	53-58
22227273-4	2012	We also checked whether curcumin has potency to regress endometriosis by modulating MMP-3 and apoptotic pathway.	Curcumin	24-32	matrix metallopeptidase 3	Homo sapiens	84-89
22227273-9	2012	Curcumin treatment regressed endometriosis by inhibiting NFkappaB translocation and MMP-3 expression.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	57-65
22227273-9	2012	Curcumin treatment regressed endometriosis by inhibiting NFkappaB translocation and MMP-3 expression.	Curcumin	0-8	matrix metallopeptidase 3	Homo sapiens	84-89
22227273-12	2012	These results were also supported by our therapeutic study, where curcumin induced apoptosis both by p53 dependent and independent manner, while celecoxib followed only p53 independent pathway.	Curcumin	66-74	tumor protein p53	Homo sapiens	101-104
22143374-8	2012	Also, pretreated with curcumin (20 mg/kg) and vitamin C restored the superoxide dismutase and catalase activities and modified the level of reduced glutathione compared with control group (p &gt; 0.01).	Curcumin	22-30	catalase	Rattus norvegicus	94-102
22281447-8	2012	Hence, it was concluded that curcumin is of potent therapeutic value in the amelioration of alcoholic neuropathy in rats and acts by inhibition of pro-inflammatory mediators like TNF-alpha and IL-1beta.	Curcumin	29-37	tumor necrosis factor	Rattus norvegicus	179-188
22281447-8	2012	Hence, it was concluded that curcumin is of potent therapeutic value in the amelioration of alcoholic neuropathy in rats and acts by inhibition of pro-inflammatory mediators like TNF-alpha and IL-1beta.	Curcumin	29-37	interleukin 1 beta	Rattus norvegicus	193-201
22568037-0	2012	Identification of curcumin targets in neuroinflammatory pathways: molecular docking scores with GSK-3beta, p38 MAPK, COX, ICE and TACE enzymes.	Curcumin	18-26	caspase 1	Homo sapiens	122-125
22568037-2	2012	The anti-inflammatory pathway of curcumin was identified through docking with of curcumin with various inflammation inducing enzymes like glycogen synthase kinase (GSK-3beta), p38 mitogen activated protein kinase (MAPK), COX, interleukin-1beta converting enzyme (ICE) and tumor necrosis factor-alpha converting enzyme (TACE).	Curcumin	33-41	mitogen-activated protein kinase 14	Homo sapiens	176-212
22568037-2	2012	The anti-inflammatory pathway of curcumin was identified through docking with of curcumin with various inflammation inducing enzymes like glycogen synthase kinase (GSK-3beta), p38 mitogen activated protein kinase (MAPK), COX, interleukin-1beta converting enzyme (ICE) and tumor necrosis factor-alpha converting enzyme (TACE).	Curcumin	33-41	caspase 1	Homo sapiens	226-261
22568037-2	2012	The anti-inflammatory pathway of curcumin was identified through docking with of curcumin with various inflammation inducing enzymes like glycogen synthase kinase (GSK-3beta), p38 mitogen activated protein kinase (MAPK), COX, interleukin-1beta converting enzyme (ICE) and tumor necrosis factor-alpha converting enzyme (TACE).	Curcumin	33-41	caspase 1	Homo sapiens	263-266
22568037-2	2012	The anti-inflammatory pathway of curcumin was identified through docking with of curcumin with various inflammation inducing enzymes like glycogen synthase kinase (GSK-3beta), p38 mitogen activated protein kinase (MAPK), COX, interleukin-1beta converting enzyme (ICE) and tumor necrosis factor-alpha converting enzyme (TACE).	Curcumin	81-89	mitogen-activated protein kinase 14	Homo sapiens	176-212
22568037-2	2012	The anti-inflammatory pathway of curcumin was identified through docking with of curcumin with various inflammation inducing enzymes like glycogen synthase kinase (GSK-3beta), p38 mitogen activated protein kinase (MAPK), COX, interleukin-1beta converting enzyme (ICE) and tumor necrosis factor-alpha converting enzyme (TACE).	Curcumin	81-89	caspase 1	Homo sapiens	226-261
22568037-2	2012	The anti-inflammatory pathway of curcumin was identified through docking with of curcumin with various inflammation inducing enzymes like glycogen synthase kinase (GSK-3beta), p38 mitogen activated protein kinase (MAPK), COX, interleukin-1beta converting enzyme (ICE) and tumor necrosis factor-alpha converting enzyme (TACE).	Curcumin	81-89	caspase 1	Homo sapiens	263-266
21973306-0	2012	Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression.	Curcumin	51-59	mitogen-activated protein kinase 3	Homo sapiens	99-105
21973306-5	2012	Therefore, in this study, we suggested that curcumin enhances the effects of MMC-mediated cytotoxicity by decreasing TP expression and ERK1/2 activation.	Curcumin	44-52	mitogen-activated protein kinase 3	Homo sapiens	135-141
21973306-6	2012	Exposure of human NSCLC cell lines H1975 and H1650 to curcumin decreased MMC-elicited phosphorylated MKK1/2-ERK1/2 protein levels.	Curcumin	54-62	mitogen-activated protein kinase 3	Homo sapiens	108-114
21973306-8	2012	Enhancement of ERK1/2 activation by constitutively active MKK1/2 (MKK1/2-CA) increased TP protein levels and cell viability in curcumin- and MMC-co-treated cells.	Curcumin	127-135	mitogen-activated protein kinase 3	Homo sapiens	15-21
21801469-6	2012	Moreover, SS increased, while curcumin decreased LPS-stimulated secretion of IL-6, whereas SB had no such effect.	Curcumin	30-38	interleukin 6	Mus musculus	77-81
22783142-7	2012	Curcumin when co-supplemented with 2-PAMCl + atropine also significantly protected serum aspartate aminotransferase (AST) and restored brain AChE activity and 5-HT level in animals sub-chronically exposed to DDVP.	Curcumin	0-8	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	117-120
22178266-11	2012	Similarly, 50 muM curcumin induced apoptosis, caused cell cycle arrest in G1-phase and increased the volume of human colorectal adenocarcinoma HT-29 cells.	Curcumin	18-26	latexin	Homo sapiens	14-17
22271351-1	2012	We found that the fluorescence intensity of curcumin (CU) can be highly enhanced by protein bovine serum albumin (BSA) and human serum albumin (HSA) in the presence of chitosan (CTS).	Curcumin	44-52	albumin	Homo sapiens	99-118
22271351-1	2012	We found that the fluorescence intensity of curcumin (CU) can be highly enhanced by protein bovine serum albumin (BSA) and human serum albumin (HSA) in the presence of chitosan (CTS).	Curcumin	44-52	albumin	Homo sapiens	99-112
22271351-1	2012	We found that the fluorescence intensity of curcumin (CU) can be highly enhanced by protein bovine serum albumin (BSA) and human serum albumin (HSA) in the presence of chitosan (CTS).	Curcumin	54-56	albumin	Homo sapiens	99-118
22271351-1	2012	We found that the fluorescence intensity of curcumin (CU) can be highly enhanced by protein bovine serum albumin (BSA) and human serum albumin (HSA) in the presence of chitosan (CTS).	Curcumin	54-56	albumin	Homo sapiens	99-112
22271351-5	2012	Based on resonance light scattering and UV-visible absorption spectroscopic analysis, mechanism studies suggested that the highly enhanced fluorescence of CU was resulted from synergic effects of favorable hydrophobic microenvironment provided by BSA and CTS and efficient intermolecular energy transfer between BSA and CU.	Curcumin	155-157	albumin	Homo sapiens	247-250
22271351-5	2012	Based on resonance light scattering and UV-visible absorption spectroscopic analysis, mechanism studies suggested that the highly enhanced fluorescence of CU was resulted from synergic effects of favorable hydrophobic microenvironment provided by BSA and CTS and efficient intermolecular energy transfer between BSA and CU.	Curcumin	155-157	albumin	Homo sapiens	312-315
22271351-7	2012	CU can combine with the BSA-CTS complex through its center carbonyl carbon, and CTS plays a key role in promoting the energy transfer process by shortening the distance between BSA and CU.	Curcumin	0-2	albumin	Homo sapiens	24-27
22271351-7	2012	CU can combine with the BSA-CTS complex through its center carbonyl carbon, and CTS plays a key role in promoting the energy transfer process by shortening the distance between BSA and CU.	Curcumin	0-2	albumin	Homo sapiens	177-180
22271351-7	2012	CU can combine with the BSA-CTS complex through its center carbonyl carbon, and CTS plays a key role in promoting the energy transfer process by shortening the distance between BSA and CU.	Curcumin	185-187	albumin	Homo sapiens	24-27
21497497-8	2012	Curcumin treatment prevented the enhanced proteasome chymotrypsin-like activity and the trend toward increased caspase-9-associated apoptosome activity at I8 in immobilized muscles.	Curcumin	0-8	caspase 9	Rattus norvegicus	111-120
22783142-7	2012	Curcumin when co-supplemented with 2-PAMCl + atropine also significantly protected serum aspartate aminotransferase (AST) and restored brain AChE activity and 5-HT level in animals sub-chronically exposed to DDVP.	Curcumin	0-8	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	89-115
22130689-12	2012	In the conjunctive treatment group of aluminium and curcumin exposure marked reduction in the gene and protein expression of NF-kappaB and TNF-alpha was observed.	Curcumin	52-60	nuclear factor kappa B subunit 1	Homo sapiens	125-134
22130689-12	2012	In the conjunctive treatment group of aluminium and curcumin exposure marked reduction in the gene and protein expression of NF-kappaB and TNF-alpha was observed.	Curcumin	52-60	tumor necrosis factor	Homo sapiens	139-148
22283550-3	2012	When curcumin concentration was increased from 2 to 20 muM, the values of fluorescence anisotropy of liposomal curcumin decreased gradually, consistent with the reduction of phase transition temperature of liposome.	Curcumin	5-13	latexin	Homo sapiens	55-58
25774181-2	2012	Graded concentration and time course experiments demonstrate that curcumin significantly upregulates phosphatidylinositol 3-kinase (PI3K), Akt, nuclear factor E2-related factor-2 (Nrf2), heme oxygenase 1 and ferritin expression, and that it significantly downregulates heme oxygenase 2, reactive oxygen species and amyloid-beta 40/42 expression.	Curcumin	66-74	AKT serine/threonine kinase 1	Homo sapiens	139-142
25774181-2	2012	Graded concentration and time course experiments demonstrate that curcumin significantly upregulates phosphatidylinositol 3-kinase (PI3K), Akt, nuclear factor E2-related factor-2 (Nrf2), heme oxygenase 1 and ferritin expression, and that it significantly downregulates heme oxygenase 2, reactive oxygen species and amyloid-beta 40/42 expression.	Curcumin	66-74	NFE2 like bZIP transcription factor 2	Homo sapiens	144-178
25774181-2	2012	Graded concentration and time course experiments demonstrate that curcumin significantly upregulates phosphatidylinositol 3-kinase (PI3K), Akt, nuclear factor E2-related factor-2 (Nrf2), heme oxygenase 1 and ferritin expression, and that it significantly downregulates heme oxygenase 2, reactive oxygen species and amyloid-beta 40/42 expression.	Curcumin	66-74	NFE2 like bZIP transcription factor 2	Homo sapiens	180-184
25774181-3	2012	These effects of curcumin on PI3K, Akt and Nrf2 were blocked by LY294002 (PI3k inhibitor) and NF-E2-related factor-2 siRNA.	Curcumin	17-25	AKT serine/threonine kinase 1	Homo sapiens	35-38
25774181-3	2012	These effects of curcumin on PI3K, Akt and Nrf2 were blocked by LY294002 (PI3k inhibitor) and NF-E2-related factor-2 siRNA.	Curcumin	17-25	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
25774181-4	2012	The results indicate that the cytoprotection conferred by curcumin on APPswe transfected SH-SY5Y cells is mediated by its ability to regulate the balance between heme oxygenase 1 and 2 via the PI3K/Akt/Nrf2 intracellular signaling pathway.	Curcumin	58-66	AKT serine/threonine kinase 1	Homo sapiens	198-201
25774181-4	2012	The results indicate that the cytoprotection conferred by curcumin on APPswe transfected SH-SY5Y cells is mediated by its ability to regulate the balance between heme oxygenase 1 and 2 via the PI3K/Akt/Nrf2 intracellular signaling pathway.	Curcumin	58-66	NFE2 like bZIP transcription factor 2	Homo sapiens	202-206
22252298-10	2012	Together, CoQ10, selenite, and curcumin act as inhibitors of RANKL-induced NFATc1 which is a downstream event of NF-kappaB signal pathway through suppression of ROS generation, thereby suggesting their potential usefulness for the treatment of bone disease associated with excessive bone resorption.	Curcumin	31-39	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	75-81
21942294-0	2012	Curcumin heals indomethacin-induced gastric ulceration by stimulation of angiogenesis and restitution of collagen fibers via VEGF and MMP-2 mediated signaling.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	125-129
21942294-4	2012	Interestingly, curcumin blocked ulceration by induction of collagenization and angiogenesis in gastric tissues via upregulation of MMP-2, membrane type (MT) 1-MMP, VEGF, and transforming growth factor (TGF)-beta at protein and messenger ribonucleic acid (mRNA) levels.	Curcumin	15-23	vascular endothelial growth factor A	Homo sapiens	164-168
21942294-4	2012	Interestingly, curcumin blocked ulceration by induction of collagenization and angiogenesis in gastric tissues via upregulation of MMP-2, membrane type (MT) 1-MMP, VEGF, and transforming growth factor (TGF)-beta at protein and messenger ribonucleic acid (mRNA) levels.	Curcumin	15-23	transforming growth factor beta 1	Homo sapiens	174-211
21942294-7	2012	INNOVATION: Our study demonstrates that curcumin-mediated healing is associated with increased MMP-2, TGF-beta, and VEGF expression and that it plays a pivotal role as an angiogenic modulator by stimulating vascular sprout formation and collagen fiber restoration in ulcerated tissues.	Curcumin	40-48	transforming growth factor beta 1	Homo sapiens	102-110
21942294-7	2012	INNOVATION: Our study demonstrates that curcumin-mediated healing is associated with increased MMP-2, TGF-beta, and VEGF expression and that it plays a pivotal role as an angiogenic modulator by stimulating vascular sprout formation and collagen fiber restoration in ulcerated tissues.	Curcumin	40-48	vascular endothelial growth factor A	Homo sapiens	116-120
22174410-6	2012	Nfe2 modulates JunD binding to the Gcm1 promoter via acetylation, as reducing JunD acetylation using the histone acetyltransferase inhibitor curcumin reverses the increased JunD DNA-binding activity observed in the absence of Nfe2.	Curcumin	141-149	nuclear factor, erythroid 2	Homo sapiens	0-4
22174410-6	2012	Nfe2 modulates JunD binding to the Gcm1 promoter via acetylation, as reducing JunD acetylation using the histone acetyltransferase inhibitor curcumin reverses the increased JunD DNA-binding activity observed in the absence of Nfe2.	Curcumin	141-149	nuclear factor, erythroid 2	Homo sapiens	226-230
22031851-4	2012	We hypothesized that curcumin, by blocking the inflammatory mediators TNF-alpha and IL-1beta, could also reduce cyclooxygenase (COX) and phospholipase expression in the kidney.	Curcumin	21-29	tumor necrosis factor	Rattus norvegicus	70-79
22031851-4	2012	We hypothesized that curcumin, by blocking the inflammatory mediators TNF-alpha and IL-1beta, could also reduce cyclooxygenase (COX) and phospholipase expression in the kidney.	Curcumin	21-29	interleukin 1 beta	Rattus norvegicus	84-92
22031851-8	2012	Compared with controls, Nx animals had higher plasma/kidney TNF-alpha and IL-1beta, which were reduced by curcumin and enalapril treatment.	Curcumin	106-114	tumor necrosis factor	Rattus norvegicus	60-69
22031851-8	2012	Compared with controls, Nx animals had higher plasma/kidney TNF-alpha and IL-1beta, which were reduced by curcumin and enalapril treatment.	Curcumin	106-114	interleukin 1 beta	Rattus norvegicus	74-82
22031851-9	2012	Nx animals had significantly elevated kidney levels of cytosolic PLA(2), calcium-independent intracellular PLA(2), COX 1, and COX 2, which were comparably reduced by curcumin and enalapril.	Curcumin	166-174	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	115-120
22685625-0	2012	Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Abeta plaques in Alzheimer"s disease.	Curcumin	27-35	amyloid beta precursor protein	Homo sapiens	78-83
22179573-3	2012	The resulting pyr-dba functioned as the enone analogs of curcumin and efficiently inhibited the activation of NF-kappaB and the growth of colorectal carcinoma HCT116 p53+/+ cells as well as the HIV-1 IN-LEDGF/p75 interaction.	Curcumin	57-65	tumor protein p53	Homo sapiens	166-169
22038833-2	2012	This is associated with increased colocalization of CFTR and K18 in the vicinity of the endoplasmic reticulum, although this is reversed by treating cells with curcumin, resulting in the rescue of F508del-CFTR.	Curcumin	160-168	CF transmembrane conductance regulator	Homo sapiens	52-56
22051236-0	2012	Transferrin-conjugated curcumin-loaded superparamagnetic iron oxide nanoparticles induce augmented cellular uptake and apoptosis in K562 cells.	Curcumin	23-31	transferrin	Homo sapiens	0-11
22030090-3	2012	Treatment with curcumin in the diet or by intraperitoneal injection significantly inhibited tumorigenicity and tumor growth, decreased the percentages of MDSCs in the spleen, blood, and tumor tissues, reduced interleukin (IL)-6 levels in the serum and tumor tissues in a human gastric cancer xenograft model and a mouse colon cancer allograft model.	Curcumin	15-23	interleukin 6	Homo sapiens	209-227
22030090-4	2012	Curcumin treatment significantly inhibited cell proliferation and colony formation of cancer cells and decreased the secretion of murine IL-6 by MDSCs in a coculture system.	Curcumin	0-8	interleukin 6	Mus musculus	137-141
22030090-5	2012	Curcumin treatment inhibited the expansion of MDSCs, the activation of Stat3 and NF-kappaB in MDSCs, and the secretion of IL-6 by MDSCs, when MDSCs were cultured in the presence of IL-1beta, or with cancer cell- or myofibroblast-conditioned medium.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	71-76
22030090-5	2012	Curcumin treatment inhibited the expansion of MDSCs, the activation of Stat3 and NF-kappaB in MDSCs, and the secretion of IL-6 by MDSCs, when MDSCs were cultured in the presence of IL-1beta, or with cancer cell- or myofibroblast-conditioned medium.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	81-90
22030090-5	2012	Curcumin treatment inhibited the expansion of MDSCs, the activation of Stat3 and NF-kappaB in MDSCs, and the secretion of IL-6 by MDSCs, when MDSCs were cultured in the presence of IL-1beta, or with cancer cell- or myofibroblast-conditioned medium.	Curcumin	0-8	interleukin 6	Homo sapiens	122-126
22030090-5	2012	Curcumin treatment inhibited the expansion of MDSCs, the activation of Stat3 and NF-kappaB in MDSCs, and the secretion of IL-6 by MDSCs, when MDSCs were cultured in the presence of IL-1beta, or with cancer cell- or myofibroblast-conditioned medium.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	181-189
22030090-6	2012	Furthermore, curcumin treatment polarized MDSCs toward a M1-like phenotype with an increased expression of CCR7 and decreased expression of dectin 1 in vivo and in vitro.	Curcumin	13-21	C-C motif chemokine receptor 7	Homo sapiens	107-111
21711158-5	2012	Instead, curcumin caused apoptosis by increasing Bax expression while decreasing the expression of Bcl-2 and Bcl-xL.	Curcumin	9-17	BCL2 associated X, apoptosis regulator	Homo sapiens	49-52
21711158-5	2012	Instead, curcumin caused apoptosis by increasing Bax expression while decreasing the expression of Bcl-2 and Bcl-xL.	Curcumin	9-17	BCL2 apoptosis regulator	Homo sapiens	99-104
21711158-5	2012	Instead, curcumin caused apoptosis by increasing Bax expression while decreasing the expression of Bcl-2 and Bcl-xL.	Curcumin	9-17	BCL2 like 1	Homo sapiens	109-115
21711158-6	2012	Curcumin induced a rapid decrease in mitochondrial membrane potential and the release of cytochrome c into the cytosol, followed by activation of caspase-9 and caspase-3.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	89-101
21711158-6	2012	Curcumin induced a rapid decrease in mitochondrial membrane potential and the release of cytochrome c into the cytosol, followed by activation of caspase-9 and caspase-3.	Curcumin	0-8	caspase 3	Homo sapiens	160-169
22335582-5	2012	Curcumin modulates multiple molecular targets and reverses insulin resistance as well as other symptoms that are associated with obesity-related cancers.	Curcumin	0-8	insulin	Homo sapiens	59-66
22038833-2	2012	This is associated with increased colocalization of CFTR and K18 in the vicinity of the endoplasmic reticulum, although this is reversed by treating cells with curcumin, resulting in the rescue of F508del-CFTR.	Curcumin	160-168	CF transmembrane conductance regulator	Homo sapiens	205-209
21607622-5	2012	Decreased level of SOD1 transcripts was observed in hypothyroid rats supplemented with curcumin alone or co-administrated with vitamin E.	Curcumin	87-95	superoxide dismutase 1	Rattus norvegicus	19-23
22197802-0	2012	Inhibition of the NF-kappaB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.	Curcumin	53-61	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	18-27
22197802-2	2012	Data indicate that curcumin, a natural ingredient of the curry spice turmeric, acts as a NF-kappaB inhibitor and exhibits both anti-inflammatory and anti-cancer properties.	Curcumin	19-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	89-98
22197802-3	2012	Curcumin analogs with enhanced activity on NF-kappaB and other inflammatory signaling pathways have been developed including the synthetic monoketone compound 3,5-Bis(2-fluorobenzylidene)-4-piperidone (EF24).	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	43-52
22191431-4	2012	Our data show that epigallocatechin gallate (EGCG) and curcumin treatment reduce insulin receptor substrate-1 (IRS-1) Ser307 phosphorylation, and curcumin is more potent to increase Akt phosphorylation in TPA induction.	Curcumin	55-63	thymoma viral proto-oncogene 1	Mus musculus	182-185
22191431-4	2012	Our data show that epigallocatechin gallate (EGCG) and curcumin treatment reduce insulin receptor substrate-1 (IRS-1) Ser307 phosphorylation, and curcumin is more potent to increase Akt phosphorylation in TPA induction.	Curcumin	146-154	thymoma viral proto-oncogene 1	Mus musculus	182-185
22191431-6	2012	With a longer incubation with palmitate, IRS-1 exhibited a dramatic depletion, and treatment with EGCG, ECG, and curcumin could reverse IRS-1 expression, Akt phosphorylation, and MAPK signaling cascade activation and improve glucose uptake in C2C12 skeletal muscle cells, especially ECG and curcumin.	Curcumin	113-121	thymoma viral proto-oncogene 1	Mus musculus	154-157
22191431-6	2012	With a longer incubation with palmitate, IRS-1 exhibited a dramatic depletion, and treatment with EGCG, ECG, and curcumin could reverse IRS-1 expression, Akt phosphorylation, and MAPK signaling cascade activation and improve glucose uptake in C2C12 skeletal muscle cells, especially ECG and curcumin.	Curcumin	113-121	mitogen-activated protein kinase 1	Mus musculus	179-183
21419610-8	2012	The ability of curcumin and quercetin to protect cartilage from stimulated aggrecan loss and to maintain this protection posttreatment may, at least in part, be due to the suppression of gene expression of ADAMTS-4 and -5.	Curcumin	15-23	ADAM metallopeptidase with thrombospondin type 1 motif 4	Bos taurus	206-221
21993423-4	2012	Curcumin decreased anchorage-independent growh in transformed breast cancer cell lines in comparison to their counterparts and increased the percentage of cells from G0/G1 with a concomitant increase in G2/M phases, as well as a decrease in PCNA and Rho-A protein expression.	Curcumin	0-8	ras homolog family member A	Homo sapiens	250-255
21993423-7	2012	Further, differential expression levels of cleaved (ADP) ribose polymerase 1 (PARP-1) and phosphorylated histone H2AX (gamma-H2AX) were observed after curcumin treatment.	Curcumin	151-159	poly(ADP-ribose) polymerase 1	Homo sapiens	78-84
21993423-8	2012	It seems that PARP-1 similar to H2AX, confers cellular protection against radiation and estrogen-induced DNA damage mediated by curcumin.	Curcumin	128-136	poly(ADP-ribose) polymerase 1	Homo sapiens	14-20
21959977-0	2012	1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitates curcumin-induced melanoma cell apoptosis by enhancing ceramide accumulation, JNK activation, and inhibiting PI3K/AKT activation.	Curcumin	68-76	mitogen-activated protein kinase 8	Homo sapiens	145-148
21959977-0	2012	1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitates curcumin-induced melanoma cell apoptosis by enhancing ceramide accumulation, JNK activation, and inhibiting PI3K/AKT activation.	Curcumin	68-76	AKT serine/threonine kinase 1	Homo sapiens	181-184
21959977-5	2012	Meanwhile, curcumin plus PDMP treatment largely inhibited the activation of pro-survival PI3K/AKT signal pathway.	Curcumin	11-19	AKT serine/threonine kinase 1	Homo sapiens	94-97
21945716-7	2012	Meanwhile, co-treatment with the 5-HT(1A) receptor antagonist WAY-100635 chronically, or with the irreversible mu-opioid receptor antangonist beta-funaltrexamine acutely, completely abrogated the anti-hyperalgesic action of curcumin on thermal stimuli.	Curcumin	224-232	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	33-50
21945716-8	2012	Collectively, these findings indicate that the descending monoamine system (coupled with spinal beta(2)-adrenoceptor and 5-HT(1A) receptor) is critical for the modality-specific antinociceptive effect of curcumin in neuropathic pain.	Curcumin	204-212	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	121-138
22101212-0	2012	Curcumin inhibits hERG potassium channels in vitro.	Curcumin	0-8	ETS transcription factor ERG	Homo sapiens	18-22
21584871-7	2012	In addition, PI3K/Akt/ GSK 3beta, ERK and p38 MAPK were activated by curcumin, while inhibitors of these signals attenuated the inhibitory effects of curcumin on melanogenesis.	Curcumin	69-77	AKT serine/threonine kinase 1	Homo sapiens	18-21
21584871-7	2012	In addition, PI3K/Akt/ GSK 3beta, ERK and p38 MAPK were activated by curcumin, while inhibitors of these signals attenuated the inhibitory effects of curcumin on melanogenesis.	Curcumin	69-77	mitogen-activated protein kinase 1	Homo sapiens	34-37
21584871-7	2012	In addition, PI3K/Akt/ GSK 3beta, ERK and p38 MAPK were activated by curcumin, while inhibitors of these signals attenuated the inhibitory effects of curcumin on melanogenesis.	Curcumin	69-77	mitogen-activated protein kinase 1	Homo sapiens	42-45
21584871-7	2012	In addition, PI3K/Akt/ GSK 3beta, ERK and p38 MAPK were activated by curcumin, while inhibitors of these signals attenuated the inhibitory effects of curcumin on melanogenesis.	Curcumin	150-158	AKT serine/threonine kinase 1	Homo sapiens	18-21
21584871-7	2012	In addition, PI3K/Akt/ GSK 3beta, ERK and p38 MAPK were activated by curcumin, while inhibitors of these signals attenuated the inhibitory effects of curcumin on melanogenesis.	Curcumin	150-158	mitogen-activated protein kinase 1	Homo sapiens	34-37
22101212-4	2012	Since curcumin shows multiple beneficial effects and clinical significance, the aim of the present study is to investigate the effect of curcumin on hERG K+ channels, elucidating its potential cardiac therapeutic or toxic effects.	Curcumin	6-14	ETS transcription factor ERG	Homo sapiens	149-153
21584871-7	2012	In addition, PI3K/Akt/ GSK 3beta, ERK and p38 MAPK were activated by curcumin, while inhibitors of these signals attenuated the inhibitory effects of curcumin on melanogenesis.	Curcumin	150-158	mitogen-activated protein kinase 1	Homo sapiens	42-45
21584871-8	2012	These results suggest that curcumin inhibits melanogenesis in human melanocytes through activation of Akt/GSK 3beta, ERK or p38 MAPK signaling pathways.	Curcumin	27-35	AKT serine/threonine kinase 1	Homo sapiens	102-105
22101212-4	2012	Since curcumin shows multiple beneficial effects and clinical significance, the aim of the present study is to investigate the effect of curcumin on hERG K+ channels, elucidating its potential cardiac therapeutic or toxic effects.	Curcumin	137-145	ETS transcription factor ERG	Homo sapiens	149-153
21584871-8	2012	These results suggest that curcumin inhibits melanogenesis in human melanocytes through activation of Akt/GSK 3beta, ERK or p38 MAPK signaling pathways.	Curcumin	27-35	mitogen-activated protein kinase 1	Homo sapiens	117-120
21584871-8	2012	These results suggest that curcumin inhibits melanogenesis in human melanocytes through activation of Akt/GSK 3beta, ERK or p38 MAPK signaling pathways.	Curcumin	27-35	mitogen-activated protein kinase 1	Homo sapiens	124-127
22101212-5	2012	In whole-cell patch-clamp experiments, we found that curcumin inhibited hERG K+ currents in HEK293 cells stably expressing hERG channels in a dose-dependent manner, with IC50 value of 5.55 muM.	Curcumin	53-61	ETS transcription factor ERG	Homo sapiens	72-76
21584871-8	2012	These results suggest that curcumin inhibits melanogenesis in human melanocytes through activation of Akt/GSK 3beta, ERK or p38 MAPK signaling pathways.	Curcumin	27-35	mitogen-activated protein kinase 1	Homo sapiens	128-132
22101212-5	2012	In whole-cell patch-clamp experiments, we found that curcumin inhibited hERG K+ currents in HEK293 cells stably expressing hERG channels in a dose-dependent manner, with IC50 value of 5.55 muM.	Curcumin	53-61	ETS transcription factor ERG	Homo sapiens	123-127
22101212-6	2012	The deactivation, inactivation and the recovery time from inactivation of hERG channels were significantly changed by acute treatment of 10 muM curcumin.	Curcumin	144-152	ETS transcription factor ERG	Homo sapiens	74-78
22101212-9	2012	We conclude that curcumin inhibits hERG K+ channels in vitro.	Curcumin	17-25	ETS transcription factor ERG	Homo sapiens	35-39
22142850-5	2012	Interestingly, the natural antioxidant curcumin could prevent both cadmium-induced IL-6 and IL-8 secretion by human airway epithelial cells.	Curcumin	39-47	interleukin 6	Homo sapiens	83-87
22142850-5	2012	Interestingly, the natural antioxidant curcumin could prevent both cadmium-induced IL-6 and IL-8 secretion by human airway epithelial cells.	Curcumin	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
22212430-11	2012	The AP-1 inhibitor curcumin (1-10 mumol/L) concentration-dependently attenuated thrombin-induced CTGF expression.	Curcumin	19-27	coagulation factor II	Rattus norvegicus	80-88
22502687-0	2012	Antifibrotic effect of curcumin in TGF-beta 1-induced myofibroblasts from human oral mucosa.	Curcumin	23-31	transforming growth factor beta 1	Homo sapiens	35-45
22038826-0	2012	Curcumin inhibits interferon-gamma signaling in colonic epithelial cells.	Curcumin	0-8	interferon gamma	Homo sapiens	18-34
22038826-4	2012	In this report we demonstrate that curcumin inhibits IFN-gamma signaling in human and mouse colonocytes.	Curcumin	35-43	interferon gamma	Homo sapiens	53-62
22038826-5	2012	Curcumin inhibited IFN-gamma-induced gene transcription, including CII-TA, MHC-II genes (HLA-DRalpha, HLA-DPalpha1, HLA-DRbeta1), and T cell chemokines (CXCL9, 10, and 11).	Curcumin	0-8	interferon gamma	Homo sapiens	19-28
22038826-5	2012	Curcumin inhibited IFN-gamma-induced gene transcription, including CII-TA, MHC-II genes (HLA-DRalpha, HLA-DPalpha1, HLA-DRbeta1), and T cell chemokines (CXCL9, 10, and 11).	Curcumin	0-8	C-X-C motif chemokine ligand 9	Homo sapiens	153-158
22038826-6	2012	Acutely, curcumin inhibited Stat1 binding to the GAS cis-element, prevented Stat1 nuclear translocation, and reduced Jak1 phosphorylation and phosphorylation of Stat1 at Tyr(701).	Curcumin	9-17	Janus kinase 1	Homo sapiens	117-121
22038826-8	2012	In summary, curcumin acts as an IFN-gamma signaling inhibitor in colonocytes with biphasic mechanisms of action, a phenomenon that may partially account for the beneficial effects of curcumin in experimental colitis and in human IBD.	Curcumin	12-20	interferon gamma	Homo sapiens	32-41
22038826-8	2012	In summary, curcumin acts as an IFN-gamma signaling inhibitor in colonocytes with biphasic mechanisms of action, a phenomenon that may partially account for the beneficial effects of curcumin in experimental colitis and in human IBD.	Curcumin	183-191	interferon gamma	Homo sapiens	32-41
22502687-7	2012	Curcumin induces apoptosis in myofibroblasts by down-regulating the Bcl-2/ Bax ratio.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	68-73
22502687-7	2012	Curcumin induces apoptosis in myofibroblasts by down-regulating the Bcl-2/ Bax ratio.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	75-78
23317243-0	2012	Curcumin inhibits TGF-beta1-induced MMP-9 and invasion through ERK and Smad signaling in breast cancer MDA- MB-231 cells.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	18-27
22994744-6	2012	At high concentrations of curcumin, TIMP-1, -2, -3 and -4 genes were up-regulated after 48 hours of treatment, their over-expression being accompanied by down-regulation of MMP-2 and MMP-9 gene expression levels in a concentration- and time-dependent manner.	Curcumin	26-34	TIMP metallopeptidase inhibitor 1	Homo sapiens	36-57
23317243-0	2012	Curcumin inhibits TGF-beta1-induced MMP-9 and invasion through ERK and Smad signaling in breast cancer MDA- MB-231 cells.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	63-66
23317243-1	2012	OBJECTIVE: To evaluate the effects of curcumin on matrixmetalloproteinase-9 (MMP-9) and invasion ability induced by transforming growth factor-beta1 (TGF-beta1) in MDA-MB-231 cells and potential mechanisms.	Curcumin	38-46	transforming growth factor beta 1	Homo sapiens	116-148
23317243-1	2012	OBJECTIVE: To evaluate the effects of curcumin on matrixmetalloproteinase-9 (MMP-9) and invasion ability induced by transforming growth factor-beta1 (TGF-beta1) in MDA-MB-231 cells and potential mechanisms.	Curcumin	38-46	transforming growth factor beta 1	Homo sapiens	150-159
23317243-4	2012	The effects of curcumin on TGF-beta1-stimulated MMP-9 and phosphorylation of Smad2, extracellular-regulated kinase (ERK), and p38 mitogen activated protein kinases (p38MAPK) were examined by Western blotting.	Curcumin	15-23	transforming growth factor beta 1	Homo sapiens	27-36
23317243-7	2012	RESULTS: Low dose curcumin (&lt;=10 muM) did not show any obvious toxicity to the cells, while 0~10 mumol/L caused a concentration-dependent reduction in cell invasion provoked by TGF-beta1.	Curcumin	18-26	latexin	Homo sapiens	36-39
23317243-8	2012	Curcumin also markedly inhibited TGF-beta1-regulated MMP-9 and activation of Smad2, ERK1/2 and p38 in a dose- and time-dependent manner.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	33-42
23317243-8	2012	Curcumin also markedly inhibited TGF-beta1-regulated MMP-9 and activation of Smad2, ERK1/2 and p38 in a dose- and time-dependent manner.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	84-90
23317243-8	2012	Curcumin also markedly inhibited TGF-beta1-regulated MMP-9 and activation of Smad2, ERK1/2 and p38 in a dose- and time-dependent manner.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	95-98
23317243-10	2012	CONCLUSION: Curcumin inhibited TGF-beta1-stimulated MMP-9 and the invasive phenotype in MDA-MB-231 cells, possibly associated with TGF-beta/Smad and TGF-beta/ERK signaling.	Curcumin	12-20	transforming growth factor beta 1	Homo sapiens	31-40
23317243-10	2012	CONCLUSION: Curcumin inhibited TGF-beta1-stimulated MMP-9 and the invasive phenotype in MDA-MB-231 cells, possibly associated with TGF-beta/Smad and TGF-beta/ERK signaling.	Curcumin	12-20	transforming growth factor beta 1	Homo sapiens	31-39
23317243-10	2012	CONCLUSION: Curcumin inhibited TGF-beta1-stimulated MMP-9 and the invasive phenotype in MDA-MB-231 cells, possibly associated with TGF-beta/Smad and TGF-beta/ERK signaling.	Curcumin	12-20	transforming growth factor beta 1	Homo sapiens	131-139
23317243-10	2012	CONCLUSION: Curcumin inhibited TGF-beta1-stimulated MMP-9 and the invasive phenotype in MDA-MB-231 cells, possibly associated with TGF-beta/Smad and TGF-beta/ERK signaling.	Curcumin	12-20	mitogen-activated protein kinase 1	Homo sapiens	158-161
22994744-7	2012	These results suggest that curcumin plays a role in regulating cell metastasis by inhibiting MMP-2 and MMP-9 and up-regulating TIMP1 and TIMP4 gene expression in breast cancer cells.	Curcumin	27-35	TIMP metallopeptidase inhibitor 1	Homo sapiens	127-132
22359429-0	2012	In vitro and In silico studies on inhibitory effects of curcumin on multi drug resistance associated protein (MRP1) in retinoblastoma cells.	Curcumin	56-64	ATP binding cassette subfamily C member 1	Homo sapiens	110-114
22359429-3	2012	In this study, we attempted to test curcumin for its potential to inhibit the expression and function of multidrug resistance associated protein 1 (MRP1) in retinoblastoma (RB) cell lines through western blot, RT-PCR and functional assays.	Curcumin	36-44	ATP binding cassette subfamily C member 1	Homo sapiens	105-146
22359429-3	2012	In this study, we attempted to test curcumin for its potential to inhibit the expression and function of multidrug resistance associated protein 1 (MRP1) in retinoblastoma (RB) cell lines through western blot, RT-PCR and functional assays.	Curcumin	36-44	ATP binding cassette subfamily C member 1	Homo sapiens	148-152
22359429-6	2012	However, inhibitory effect of curcumin on MRP1 function was observed as a decrease in the efflux of fluorescent substrate.	Curcumin	30-38	ATP binding cassette subfamily C member 1	Homo sapiens	42-46
22359429-7	2012	Moreover, Curcumin did not affect 8-azido-ATP-biotin binding to MRP1 and it also showed inhibition of ATP-hydrolysis stimulated by quercetin, which is indicative of curcumin"s interaction with the substrate binding site of MRP1.	Curcumin	10-18	ATP binding cassette subfamily C member 1	Homo sapiens	223-227
22359429-7	2012	Moreover, Curcumin did not affect 8-azido-ATP-biotin binding to MRP1 and it also showed inhibition of ATP-hydrolysis stimulated by quercetin, which is indicative of curcumin"s interaction with the substrate binding site of MRP1.	Curcumin	165-173	ATP binding cassette subfamily C member 1	Homo sapiens	223-227
22359429-8	2012	Furthermore, homology modelling and docking simulation studies of MRP1 also provided deeper insights into the molecular interactions, thereby inferring the potential binding mode of curcumin into the substrate binding site of MRP1.	Curcumin	182-190	ATP binding cassette subfamily C member 1	Homo sapiens	66-70
22359429-8	2012	Furthermore, homology modelling and docking simulation studies of MRP1 also provided deeper insights into the molecular interactions, thereby inferring the potential binding mode of curcumin into the substrate binding site of MRP1.	Curcumin	182-190	ATP binding cassette subfamily C member 1	Homo sapiens	226-230
22108826-0	2012	Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression.	Curcumin	0-8	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	108-112
23275693-0	2012	Molecular docking studies on inhibition of Stat3 dimerization by curcumin natural derivatives and its conjugates with amino acids.	Curcumin	65-73	signal transducer and activator of transcription 3	Homo sapiens	43-48
23275693-4	2012	The present computational study provides insights into the inhibition of Stat3 dimerization by curcumin natural derivatives and its conjugates with amino acids.	Curcumin	95-103	signal transducer and activator of transcription 3	Homo sapiens	73-78
23275693-5	2012	The involvement of residues like LYS-591, ARG-609, SER-611, GLU-612, SER-613, SER-636 and VAL-637 seems to play an important role in binding of curcumin natural derivatives and its amino acids conjugates with Src Homology (SH2) domain of Stat3 monomer.	Curcumin	144-152	signal transducer and activator of transcription 3	Homo sapiens	238-243
22108826-3	2012	In this study, we probed EZH2 function in pancreatic cancer using diflourinated-curcumin (CDF), a novel analogue of the turmeric spice component curcumin that has antioxidant properties.	Curcumin	80-88	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	25-29
22508043-5	2012	The combination of curcumin (10 muM) and trolox (10-50 muM) induced apoptosis of cancer cells as evidenced by PARP cleavage and caspase-3 activation.	Curcumin	19-27	latexin	Homo sapiens	32-35
26069496-0	2012	Apoptosis-induced anticancer effect of transferrin-conjugated solid lipid nanoparticles of curcumin.	Curcumin	91-99	transferrin	Homo sapiens	39-50
22508043-5	2012	The combination of curcumin (10 muM) and trolox (10-50 muM) induced apoptosis of cancer cells as evidenced by PARP cleavage and caspase-3 activation.	Curcumin	19-27	latexin	Homo sapiens	55-58
22508043-5	2012	The combination of curcumin (10 muM) and trolox (10-50 muM) induced apoptosis of cancer cells as evidenced by PARP cleavage and caspase-3 activation.	Curcumin	19-27	caspase 3	Homo sapiens	128-137
22508043-6	2012	Furthermore, expression of the pro-apoptotic protein Bad was up-regulated and expression of the anti-apoptotic proteins Bcl-2 and Bcl-xl was down-regulated in cells that had been treated with trolox plus curcumin.	Curcumin	204-212	BCL2 apoptosis regulator	Homo sapiens	120-125
22508043-6	2012	Furthermore, expression of the pro-apoptotic protein Bad was up-regulated and expression of the anti-apoptotic proteins Bcl-2 and Bcl-xl was down-regulated in cells that had been treated with trolox plus curcumin.	Curcumin	204-212	BCL2 like 1	Homo sapiens	130-136
22005927-8	2012	Western blot revealed that curcumin reduced ox-LDL- induced p38 MAPK phosphorylation and nuclear NF-kappaB p65 protein at the indicated concentration.	Curcumin	27-35	synaptotagmin 1	Rattus norvegicus	107-110
22830351-0	2012	pKa, zinc- and serum albumin-binding of curcumin and two novel biologically-active chemically-modified curcumins.	Curcumin	40-48	albumin	Homo sapiens	15-28
22284780-11	2012	Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6.	Curcumin	36-44	nuclear factor kappa B subunit 1	Homo sapiens	114-123
22284780-11	2012	Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6.	Curcumin	36-44	nuclear factor kappa B subunit 1	Homo sapiens	125-134
22284780-11	2012	Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6.	Curcumin	36-44	tumor necrosis factor	Homo sapiens	222-231
22284780-11	2012	Specifically, apiegenin, baicalein, curcumin, EGCG, genistein, luteolin, oridonin, quercetin, and wogonin repress NF-kappaB (NF-kappaB, a proinflammatory transcription factor) and inhibit proinflammatory cytokines such as TNF-alpha and IL-6.	Curcumin	36-44	interleukin 6	Homo sapiens	236-240
21876713-0	2012	The Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed Breast Cancer: An In Vitro and In Vivo Comparison Study with Herceptin.	Curcumin	25-33	erb-b2 receptor tyrosine kinase 2	Homo sapiens	54-59
21876713-2	2012	We hypothesized that the ability of curcumin to downregulate HER-2 oncoprotein and inhibit the signal transduction pathway of PI3K/Akt, MAPK, and NF-kappaB activation may be important in the treatment of HER-2-overexpressed breast cancer.	Curcumin	36-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	61-66
21876713-2	2012	We hypothesized that the ability of curcumin to downregulate HER-2 oncoprotein and inhibit the signal transduction pathway of PI3K/Akt, MAPK, and NF-kappaB activation may be important in the treatment of HER-2-overexpressed breast cancer.	Curcumin	36-44	AKT serine/threonine kinase 1	Homo sapiens	131-134
21876713-2	2012	We hypothesized that the ability of curcumin to downregulate HER-2 oncoprotein and inhibit the signal transduction pathway of PI3K/Akt, MAPK, and NF-kappaB activation may be important in the treatment of HER-2-overexpressed breast cancer.	Curcumin	36-44	nuclear factor kappa B subunit 1	Homo sapiens	146-155
21876713-2	2012	We hypothesized that the ability of curcumin to downregulate HER-2 oncoprotein and inhibit the signal transduction pathway of PI3K/Akt, MAPK, and NF-kappaB activation may be important in the treatment of HER-2-overexpressed breast cancer.	Curcumin	36-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	204-209
21876713-4	2012	The in vivo effect of curcumin on HER-2-overexpressed breast cancer was investigated with the HER-2-overexpressed BT-474 xenograft model.	Curcumin	22-30	erb-b2 receptor tyrosine kinase 2	Homo sapiens	34-39
21876713-8	2012	When treated with curcumin, the HER-2 oncoprotein, phosphorylation of Akt, MAPK and expression of NF-kappaB were decreased in both BT-474 and SK-BR-3-hr cells.	Curcumin	18-26	erb-b2 receptor tyrosine kinase 2	Homo sapiens	32-37
21876713-8	2012	When treated with curcumin, the HER-2 oncoprotein, phosphorylation of Akt, MAPK and expression of NF-kappaB were decreased in both BT-474 and SK-BR-3-hr cells.	Curcumin	18-26	AKT serine/threonine kinase 1	Homo sapiens	70-73
21876713-8	2012	When treated with curcumin, the HER-2 oncoprotein, phosphorylation of Akt, MAPK and expression of NF-kappaB were decreased in both BT-474 and SK-BR-3-hr cells.	Curcumin	18-26	nuclear factor kappa B subunit 1	Homo sapiens	98-107
21876713-11	2012	The results suggested that curcumin has potential as a treatment for HER-2-overexpressed breast cancer.	Curcumin	27-35	erb-b2 receptor tyrosine kinase 2	Homo sapiens	69-74
22345874-6	2012	Pretreatment with the curcumin significantly protected myocardium from the toxic effects of Dox by reducing the elevated level of biomarker enzymes like LDH and CPK and biochemical parameters such as AST, ALT and ALP back to normal.	Curcumin	22-30	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	200-203
22155627-10	2012	We also found that the mice treated with dendrosomal curcumin, showed a significant increase in splenocyte proliferation and IFN-gamma production as well as a significant decrease in IL-4 production.	Curcumin	53-61	interferon gamma	Mus musculus	125-134
22489138-0	2012	BDMC33, A curcumin derivative suppresses inflammatory responses in macrophage-like cellular system: role of inhibition in NF-kappaB and MAPK signaling pathways.	Curcumin	10-18	nuclear factor kappa B subunit 1	Homo sapiens	122-131
22606012-6	2012	These results suggested that curcumin might enhance the cytotoxicity of PS-341 by interacting with NF-kappaB, at least in part, through JNK mechanism.	Curcumin	29-37	mitogen-activated protein kinase 8	Homo sapiens	136-139
22754355-0	2012	The three dimensional Quantitative Structure Activity Relationships (3D-QSAR) and docking studies of curcumin derivatives as androgen receptor antagonists.	Curcumin	101-109	androgen receptor	Homo sapiens	125-142
22754355-2	2012	3D-QSAR and Molecular docking methods were performed on curcumin derivatives as androgen receptor antagonists.	Curcumin	56-64	androgen receptor	Homo sapiens	80-97
22942754-5	2012	Western blot analyses showed that curcumin decreased the ionomycin-induced phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and synaptic vesicle-associated protein synapsin I, the main presynaptic target of ERK.	Curcumin	34-42	Eph receptor B1	Rattus norvegicus	141-144
23221717-4	2012	Polyphenols, including catechins, curcumin, resveratrol, silibinin, and sulfurous compound alpha-lipoic acid, were found to inhibit both HOCl- and human MPO-induced Cl-Guo formation dose-dependently.	Curcumin	34-42	myeloperoxidase	Homo sapiens	153-156
22606206-6	2012	Cell viability was increased, but DeltaPsi(m), ROS production, activation of caspase 3, and cell death were decreased in J5 cells pretreated with BAPTA for 2 h followed by the treatment of 25 muM curcumin.	Curcumin	196-204	caspase 3	Homo sapiens	77-86
22036766-0	2012	Aminoguanidine and curcumin attenuated tumor necrosis factor (TNF)-alpha-induced oxidative stress, colitis and hepatotoxicity in mice.	Curcumin	19-27	tumor necrosis factor	Mus musculus	39-72
22138522-0	2012	Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression.	Curcumin	0-8	toll-like receptor 4	Mus musculus	109-113
22138522-6	2012	Also, curcumin pretreatment reduced intrahepatic expression of genes encoding pro-inflammatory molecules such as tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) as compared with the vehicle controls, but augmented anti-inflammatory cytokine interleukin 10 (IL-10) by enzyme linked immunosorbent assay (ELISA).	Curcumin	6-14	tumor necrosis factor	Mus musculus	113-140
22138522-6	2012	Also, curcumin pretreatment reduced intrahepatic expression of genes encoding pro-inflammatory molecules such as tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) as compared with the vehicle controls, but augmented anti-inflammatory cytokine interleukin 10 (IL-10) by enzyme linked immunosorbent assay (ELISA).	Curcumin	6-14	tumor necrosis factor	Mus musculus	142-151
22138522-6	2012	Also, curcumin pretreatment reduced intrahepatic expression of genes encoding pro-inflammatory molecules such as tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) as compared with the vehicle controls, but augmented anti-inflammatory cytokine interleukin 10 (IL-10) by enzyme linked immunosorbent assay (ELISA).	Curcumin	6-14	interferon gamma	Mus musculus	157-184
22138522-6	2012	Also, curcumin pretreatment reduced intrahepatic expression of genes encoding pro-inflammatory molecules such as tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) as compared with the vehicle controls, but augmented anti-inflammatory cytokine interleukin 10 (IL-10) by enzyme linked immunosorbent assay (ELISA).	Curcumin	6-14	interleukin 10	Mus musculus	266-280
22138522-6	2012	Also, curcumin pretreatment reduced intrahepatic expression of genes encoding pro-inflammatory molecules such as tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) as compared with the vehicle controls, but augmented anti-inflammatory cytokine interleukin 10 (IL-10) by enzyme linked immunosorbent assay (ELISA).	Curcumin	6-14	interleukin 10	Mus musculus	282-287
22138522-7	2012	Furthermore, the expression levels of Toll-like receptor (TLR) 2, TLR4 and TLR9 mRNA or protein in liver tissues were significantly lowered by curcumin treatment.	Curcumin	143-151	toll-like receptor 4	Mus musculus	66-70
22138522-10	2012	The beneficial effect of curcumin may be partly mediated by inhibiting the expression levels of TLR2, TLR4 and TLR9 in the liver.	Curcumin	25-33	toll-like receptor 4	Mus musculus	102-106
22489192-5	2012	Apart from transcription factors and apoptosis, emerging studies shed light on latent targets of curcumin against epidermal growth factor receptor (EGFR), microRNAs (miRNA), autophagy and cancer stem cell.	Curcumin	97-105	epidermal growth factor receptor	Homo sapiens	114-146
22489192-5	2012	Apart from transcription factors and apoptosis, emerging studies shed light on latent targets of curcumin against epidermal growth factor receptor (EGFR), microRNAs (miRNA), autophagy and cancer stem cell.	Curcumin	97-105	epidermal growth factor receptor	Homo sapiens	148-152
22489192-9	2012	Therefore, EGFR-, miRNA-, autophagy- and cancer stem cell-based therapy in the presence of curcumin might be promising mechanisms and targets in the therapeutic strategy of lung cancer.	Curcumin	91-99	epidermal growth factor receptor	Homo sapiens	11-15
22679371-5	2012	The results showed that liposomal curcumin inhibited nuclear factor-kappaB pathway and downregulated inflammatory factors including tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, and transforming growth factor-beta induced by thoracic irradiation.	Curcumin	34-42	tumor necrosis factor	Mus musculus	132-159
22679371-5	2012	The results showed that liposomal curcumin inhibited nuclear factor-kappaB pathway and downregulated inflammatory factors including tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, and transforming growth factor-beta induced by thoracic irradiation.	Curcumin	34-42	interleukin 6	Mus musculus	161-179
22888226-11	2012	In the animal model of asthma, curcumin-SLNs effectively suppressed airway hyperresponsiveness and inflammatory cell infiltration and also significantly inhibited the expression of T-helper-2-type cytokines, such as interleukin-4 and interleukin-13, in bronchoalveolar lavage fluid compared to the asthma group and curcumin-treated group.	Curcumin	31-39	interleukin 13	Rattus norvegicus	234-248
22942754-6	2012	These results show that curcumin-mediated inhibition of glutamate release involves modulating downstream events by controlling synaptic vesicle recruitment and exocytosis, possibly through a decrease of MAPK/ERK activation and synapsin I phosphorylation, thereby decreasing synaptic vesicle availability for exocytosis.	Curcumin	24-32	Eph receptor B1	Rattus norvegicus	208-211
22876123-2	2012	Because curcumin has shown anti-allergic activity in an asthma and contact dermatitis laboratory models, we examined whether administration of curcumin could affect the severity of AC and modify the immune response to ovalbumin (OVA) allergen in an experimental AC model.	Curcumin	143-151	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	218-227
22886017-5	2012	In this study, we investigated the protective effects of curcumin against mitochondrial dysfunction induced by Abeta.	Curcumin	57-65	amyloid beta precursor protein	Homo sapiens	111-116
22886017-6	2012	Based on the assay results of mitochondrial metabolic markers, we found that curcumin protects human neuroblastoma SH-SY5Y cells against the Abeta-induced damage of mitochondrial energy metabolism.	Curcumin	77-85	amyloid beta precursor protein	Homo sapiens	141-146
22886017-7	2012	Curcumin inhibits Abeta-induced mitochondrial depolarization of membrane potential (Deltapsim) and suppresses mitochondrial apoptosis-related proteins including cytochrome c, caspase-3, and Bax, which are activated by Abeta.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	18-23
22886017-7	2012	Curcumin inhibits Abeta-induced mitochondrial depolarization of membrane potential (Deltapsim) and suppresses mitochondrial apoptosis-related proteins including cytochrome c, caspase-3, and Bax, which are activated by Abeta.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	161-173
22886017-7	2012	Curcumin inhibits Abeta-induced mitochondrial depolarization of membrane potential (Deltapsim) and suppresses mitochondrial apoptosis-related proteins including cytochrome c, caspase-3, and Bax, which are activated by Abeta.	Curcumin	0-8	caspase 3	Homo sapiens	175-184
22886017-7	2012	Curcumin inhibits Abeta-induced mitochondrial depolarization of membrane potential (Deltapsim) and suppresses mitochondrial apoptosis-related proteins including cytochrome c, caspase-3, and Bax, which are activated by Abeta.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	190-193
22886017-7	2012	Curcumin inhibits Abeta-induced mitochondrial depolarization of membrane potential (Deltapsim) and suppresses mitochondrial apoptosis-related proteins including cytochrome c, caspase-3, and Bax, which are activated by Abeta.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	218-223
22886017-9	2012	Curcumin normalizes cellular antioxidant enzymes (including SOD and catalase) in both protein expression and activity and decreases oxidative stress level in Abeta-treated cells.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	158-163
22886017-11	2012	This study demonstrates curcumin-mediated neuroprotection against Abeta-induced mitochondrial metabolic deficiency and abnormal alteration of oxidative stress.	Curcumin	24-32	amyloid beta precursor protein	Homo sapiens	66-71
22886017-12	2012	Inhibition of GSK-3beta is involved in the protection of curcumin against Abeta-induced mitochondrial dysfunction.	Curcumin	57-65	amyloid beta precursor protein	Homo sapiens	74-79
22876123-0	2012	Curcumin suppresses ovalbumin-induced allergic conjunctivitis.	Curcumin	0-8	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	20-29
21742514-2	2012	Meanwhile, experimental studies indicate that curcumin attenuates both the binding of autoantibodies from systemic lupus erythematosus patients to their cognate antigens and also the inflammatory responses of tumor necrosis factor-alpha-stimulated human endothelial cells.	Curcumin	46-54	tumor necrosis factor	Homo sapiens	209-236
22876123-9	2012	OVA challenge resulted in activation of the production of inducible nitric oxide (iNOS), and curcumin treatment inhibited iNOS production in the conjunctiva.	Curcumin	93-101	nitric oxide synthase 2, inducible	Mus musculus	122-126
22973975-7	2012	Preincubation of Detroit cells with 200 muM curcumin for 5 to 60 min resulted in complete suppression of the release of tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, monocyte chemoattractant protein 1, granulocyte macrophage-colony stimulating factor, and vascular endothelial growth factor.	Curcumin	44-52	tumor necrosis factor	Homo sapiens	120-147
22156608-3	2012	Curcumins restore Abeta phagocytosis by peripheral blood mononuclear cells (PBMCs) from AD patients and Abeta clearance with upregulation of key genes including MGAT3, vitamin D receptor (VDR) and Toll-like receptors (TLRs).	Curcumin	0-9	amyloid beta precursor protein	Homo sapiens	18-23
22973975-7	2012	Preincubation of Detroit cells with 200 muM curcumin for 5 to 60 min resulted in complete suppression of the release of tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, monocyte chemoattractant protein 1, granulocyte macrophage-colony stimulating factor, and vascular endothelial growth factor.	Curcumin	44-52	interleukin 6	Homo sapiens	149-167
22973975-7	2012	Preincubation of Detroit cells with 200 muM curcumin for 5 to 60 min resulted in complete suppression of the release of tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, monocyte chemoattractant protein 1, granulocyte macrophage-colony stimulating factor, and vascular endothelial growth factor.	Curcumin	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
22973975-7	2012	Preincubation of Detroit cells with 200 muM curcumin for 5 to 60 min resulted in complete suppression of the release of tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, monocyte chemoattractant protein 1, granulocyte macrophage-colony stimulating factor, and vascular endothelial growth factor.	Curcumin	44-52	vascular endothelial growth factor A	Homo sapiens	265-299
22919438-0	2012	Curcumin induces Nrf2 nuclear translocation and prevents glomerular hypertension, hyperfiltration, oxidant stress, and the decrease in antioxidant enzymes in 5/6 nephrectomized rats.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	17-21
22919438-2	2012	The purpose of this work was to know if the bifunctional antioxidant curcumin may induce nuclear translocation of Nrf2 and prevents 5/6NX-induced oxidant stress, renal injury, decrease in antioxidant enzymes, and glomerular hypertension and hyperfiltration.	Curcumin	69-77	NFE2 like bZIP transcription factor 2	Rattus norvegicus	114-118
22919438-8	2012	It is concluded that the protective effect of curcumin against 5/6NX-induced glomerular and systemic hypertension, hyperfiltration, renal dysfunction, and renal injury was associated with the nuclear translocation of Nrf2 and the prevention of both oxidant stress and the decrease of antioxidant enzymes.	Curcumin	46-54	NFE2 like bZIP transcription factor 2	Rattus norvegicus	217-221
21567511-5	2012	The observation suggested that combined treatment of a low dosage of curcumin with inhibitors against epidermal growth factor receptor (EGFR), insulin-like growth factor 1 (IGF-1R), fibroblast growth factors receptor (FGFR), phosphatidylinositol 3-kinases (PI3K) or NF-kappaB signaling pathway may be a potential adjuvant therapy beneficial to NSCLC patients.	Curcumin	69-77	epidermal growth factor receptor	Homo sapiens	102-134
21567511-5	2012	The observation suggested that combined treatment of a low dosage of curcumin with inhibitors against epidermal growth factor receptor (EGFR), insulin-like growth factor 1 (IGF-1R), fibroblast growth factors receptor (FGFR), phosphatidylinositol 3-kinases (PI3K) or NF-kappaB signaling pathway may be a potential adjuvant therapy beneficial to NSCLC patients.	Curcumin	69-77	epidermal growth factor receptor	Homo sapiens	136-140
21567511-5	2012	The observation suggested that combined treatment of a low dosage of curcumin with inhibitors against epidermal growth factor receptor (EGFR), insulin-like growth factor 1 (IGF-1R), fibroblast growth factors receptor (FGFR), phosphatidylinositol 3-kinases (PI3K) or NF-kappaB signaling pathway may be a potential adjuvant therapy beneficial to NSCLC patients.	Curcumin	69-77	insulin like growth factor 1	Homo sapiens	143-171
22881234-10	2012	Curcumin significantly ameliorated the ischemia-induced alterations in serum TNF-alpha and associated histological changes but did not affect the alterations in renal artery blood flow, glomerular (glomerular filtration rate, renal blood flow) or tubular (urinary volume, urinary sodium and fractional excretion of sodium) functions following 30 or 45 min of IRI.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	77-86
22952749-5	2012	The treatment of PCa cells with CDF, a novel Curcumin-derived synthetic analogue previously showed anti-tumor activity in vivo, inhibited the productions of VEGF and IL-6, and down-regulated the expression of Nanog, Oct4, EZH2 mRNAs, as well as miR-21 under hypoxic condition.	Curcumin	45-53	interleukin 6	Homo sapiens	32-35
22172229-6	2012	The expression levels of tumor necrosis factor-alpha, interleukin-6, and cyclooxygenase-2 (COX-2) mRNAs on the colonic mucosa of AOM-treated mice were significantly decreased by curcumin administration.	Curcumin	178-186	tumor necrosis factor	Mus musculus	25-52
22172229-6	2012	The expression levels of tumor necrosis factor-alpha, interleukin-6, and cyclooxygenase-2 (COX-2) mRNAs on the colonic mucosa of AOM-treated mice were significantly decreased by curcumin administration.	Curcumin	178-186	interleukin 6	Mus musculus	54-67
23185512-4	2012	CCL2-mediated VCAM-1 expression was attenuated by CCR2 inhibitor (RS102895), PKCdelta inhibitor (rottlerin), p38MAPK inhibitor (SB203580), and AP-1 inhibitors (curcumin and tanshinone IIA).	Curcumin	160-168	vascular cell adhesion molecule 1	Homo sapiens	14-20
23285282-12	2012	Curcumin inhibited the RPE-choroid levels of TNF-alpha (P&lt;0.05), MCP-1 (P&lt;0.05) and ICAM-1 (P&lt;0.05), and suppressed the activation of NF-kappaB in nuclear extracts (P&lt;0.05) and the activation of HIF-1alpha (P&lt;0.05).	Curcumin	0-8	tumor necrosis factor	Mus musculus	45-54
23285282-12	2012	Curcumin inhibited the RPE-choroid levels of TNF-alpha (P&lt;0.05), MCP-1 (P&lt;0.05) and ICAM-1 (P&lt;0.05), and suppressed the activation of NF-kappaB in nuclear extracts (P&lt;0.05) and the activation of HIF-1alpha (P&lt;0.05).	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-152
23285282-13	2012	CONCLUSION: Curcumin treatment led to the suppression of CNV development together with inflammatory and angiogenic processes including NF-kappaB and HIF-1alpha activation, the up-regulation of inflammatory and angiogenic cytokines, and infiltrating macrophages and granulocytes.	Curcumin	12-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-144
23251674-11	2012	The inhibited phosphorylation of Akt and GSK-3beta was also restored by curcumin treatment.	Curcumin	72-80	AKT serine/threonine kinase 1	Rattus norvegicus	33-36
23152782-11	2012	Western blot analysis suggested that pretreatment with Ki-67-7 sensitized bladder cancer cells to curcumin-mediated apoptosis and cell cycle arrest by p53- and p21-independent mechanisms.	Curcumin	98-106	tumor protein p53	Homo sapiens	151-154
22442659-0	2012	A chemical analog of curcumin as an improved inhibitor of amyloid Abeta oligomerization.	Curcumin	21-29	amyloid beta precursor protein	Homo sapiens	66-71
22899991-0	2012	Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.	Curcumin	22-30	signal transducer and activator of transcription 3	Homo sapiens	47-52
22899991-3	2012	These compounds are structurally distinct curcumin analogs that bind selectively to the SH2 domain of STAT3 to inhibit its phosphorylation and dimerization.	Curcumin	42-50	signal transducer and activator of transcription 3	Homo sapiens	102-107
22899991-9	2012	In contrast to FLLL32, curcumin and FLLL62 reduced downstream STAT1-mediated gene expression of IRF1 as determined by Real Time PCR.	Curcumin	23-31	interferon regulatory factor 1	Homo sapiens	96-100
22745783-9	2012	Pretreatment with curcumin by oral gavage (45 mg/kg) 1 h before exposure to DEP significantly prevented the influx of inflammatory cells and the increase of TNF alpha in BAL, and the increased airway resistance caused by DEP.	Curcumin	18-26	tumor necrosis factor	Mus musculus	157-166
22745783-10	2012	Likewise, curcumin prevented the increase of SBP, CRP, TNF alpha, D-dimer and PAI-1.	Curcumin	10-18	tumor necrosis factor	Mus musculus	55-64
22745783-13	2012	Our findings indicate that curcumin is a potent anti-inflammatory agent that prevents the release of TNFalpha and protects against the pulmonary and cardiovascular effects of DEP.	Curcumin	27-35	tumor necrosis factor	Mus musculus	101-109
22363450-12	2012	CONCLUSION/SIGNIFICANCE: Curcumin is a potent inhibitor of esophageal cancer growth that targets the Notch-1 activating gamma-secretase complex proteins.	Curcumin	25-33	notch receptor 1	Homo sapiens	101-108
22363450-13	2012	These data suggest that Notch signaling inhibition is a novel mechanism of action for curcumin during therapeutic intervention in esophageal cancers.	Curcumin	86-94	notch receptor 1	Homo sapiens	24-29
22363450-0	2012	Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling.	Curcumin	0-8	notch receptor 1	Homo sapiens	74-79
21924245-3	2011	In the current report, we investigated the potency of DBM, DBP, and DBA in relation to curcumin for their ability to suppress TNF-induced NF-kappaB activation, NF-kappaB-regulated gene products, and cell proliferation.	Curcumin	87-95	tumor necrosis factor	Homo sapiens	126-129
22363450-3	2012	Here, we have determined that curcumin inhibits esophageal cancer growth via a mechanism mediated through the Notch signaling pathway.	Curcumin	30-38	notch receptor 1	Homo sapiens	110-115
22363450-5	2012	Furthermore, curcumin treatment induced apoptosis through caspase 3 activation, confirmed by an increase in the ratio of Bax to Bcl2.	Curcumin	13-21	caspase 3	Homo sapiens	58-67
22363450-5	2012	Furthermore, curcumin treatment induced apoptosis through caspase 3 activation, confirmed by an increase in the ratio of Bax to Bcl2.	Curcumin	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	121-124
22363450-5	2012	Furthermore, curcumin treatment induced apoptosis through caspase 3 activation, confirmed by an increase in the ratio of Bax to Bcl2.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	128-132
22363450-8	2012	Furthermore, curcumin treatment led to reduced Notch-1 activation, expression of Jagged-1 and its downstream target Hes-1.	Curcumin	13-21	notch receptor 1	Homo sapiens	47-54
22363450-11	2012	Finally, curcumin treatment down-regulate the expressions of Notch-1 specific microRNAs miR-21 and miR-34a, and upregulated tumor suppressor let-7a miRNA.	Curcumin	9-17	notch receptor 1	Homo sapiens	61-68
22860163-0	2011	"Clicked" sugar-curcumin conjugate: modulator of amyloid-beta and tau peptide aggregation at ultralow concentrations.	Curcumin	16-24	amyloid beta precursor protein	Homo sapiens	49-61
22860163-1	2011	The synthesis of a water/plasma soluble, noncytotoxic, "clicked" sugar-derivative of curcumin with amplified bioefficacy in modulating amyloid-beta and tau peptide aggregation is presented.	Curcumin	85-93	amyloid beta precursor protein	Homo sapiens	135-147
22860163-2	2011	Curcumin inhibits amyloid-beta and tau peptide aggregation at micromolar concentrations; the sugar-curcumin conjugate inhibits Abeta and tau peptide aggregation at concentrations as low as 8 nM and 0.1 nM, respectively.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	18-30
22860163-2	2011	Curcumin inhibits amyloid-beta and tau peptide aggregation at micromolar concentrations; the sugar-curcumin conjugate inhibits Abeta and tau peptide aggregation at concentrations as low as 8 nM and 0.1 nM, respectively.	Curcumin	99-107	amyloid beta precursor protein	Homo sapiens	127-132
21807037-0	2011	Curcumin derivatives as new ligands of Abeta peptides.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	39-44
21807037-2	2011	All compounds retained Curcumin ability to bind Abeta peptide oligomers without inducing their aggregation.	Curcumin	23-31	amyloid beta precursor protein	Homo sapiens	48-53
22431984-5	2012	Curcumin, an antagonist of NF-kappaB-dependent transcription, inhibited IL-8 production from ex vivo porcine vaginal explants at nontoxic doses.	Curcumin	0-8	interleukin-8	Oryctolagus cuniculus	72-76
21924245-3	2011	In the current report, we investigated the potency of DBM, DBP, and DBA in relation to curcumin for their ability to suppress TNF-induced NF-kappaB activation, NF-kappaB-regulated gene products, and cell proliferation.	Curcumin	87-95	nuclear factor kappa B subunit 1	Homo sapiens	138-147
21924245-3	2011	In the current report, we investigated the potency of DBM, DBP, and DBA in relation to curcumin for their ability to suppress TNF-induced NF-kappaB activation, NF-kappaB-regulated gene products, and cell proliferation.	Curcumin	87-95	nuclear factor kappa B subunit 1	Homo sapiens	160-169
21924245-7	2011	For suppression of TNF-induced expression of NF-kappaB-regulated gene products such as COX-2 (inflammation marker), cyclin D1 (proliferation marker), and VEGF (angiogenesis marker), DBA and curcumin were more active than DBM.	Curcumin	190-198	tumor necrosis factor	Homo sapiens	19-22
22037513-3	2011	Our study found that Nrf2 nuclear translocation and the activity of NAD(P)H quinone oxidoreductase (NQO1) were increased significantly after treatment of astrocytes with tert-butylhydroquinone (tBHQ), resveratrol, or curcumin, at 20-50muM.	Curcumin	217-225	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
21924245-7	2011	For suppression of TNF-induced expression of NF-kappaB-regulated gene products such as COX-2 (inflammation marker), cyclin D1 (proliferation marker), and VEGF (angiogenesis marker), DBA and curcumin were more active than DBM.	Curcumin	190-198	nuclear factor kappa B subunit 1	Homo sapiens	45-54
22037513-3	2011	Our study found that Nrf2 nuclear translocation and the activity of NAD(P)H quinone oxidoreductase (NQO1) were increased significantly after treatment of astrocytes with tert-butylhydroquinone (tBHQ), resveratrol, or curcumin, at 20-50muM.	Curcumin	217-225	NAD(P)H quinone dehydrogenase 1	Homo sapiens	100-104
22013068-0	2011	Curcumin enhances the efficacy of chemotherapy by tailoring p65NFkappaB-p300 cross-talk in favor of p53-p300 in breast cancer.	Curcumin	0-8	tumor protein p53	Homo sapiens	100-103
22013068-5	2011	Interestingly, curcumin pretreatment of drug-resistant cells alleviated SMAR1-mediated p65NFkappaB activation and hence restored doxorubicin sensitivity.	Curcumin	15-23	BTG3 associated nuclear protein	Homo sapiens	72-77
22013068-7	2011	Importantly, promyelocyte leukemia-mediated SMAR1 sequestration that relieved the repression of apoptosis-inducing genes was indispensable for such chemo-sensitizing ability of curcumin.	Curcumin	177-185	BTG3 associated nuclear protein	Homo sapiens	44-49
25786365-5	2011	Coenzyme Q10 nanoparticulates reduced only C-reactive protein levels, whereas curcumin nanoparticles reduced levels of C-reactive protein, interleukin-6 and tumor necrosis factor-alpha.	Curcumin	78-86	C-reactive protein	Rattus norvegicus	119-137
21926905-9	2011	Correspondingly, glutamate transporter-1 was preserved after SAH in curcumin-treated rats.	Curcumin	68-76	solute carrier family 1 member 2	Rattus norvegicus	17-40
22101335-0	2011	Curcumin induces Apaf-1-dependent, p21-mediated caspase activation and apoptosis.	Curcumin	0-8	apoptotic peptidase activating factor 1	Homo sapiens	17-23
22101335-3	2011	In this study, we demonstrate that curcumin treatment of cancer cells caused dose- and time-dependent caspase-3 activation, which is required for apoptosis as confirmed using the pan caspase inhibitor, z-VAD.	Curcumin	35-43	caspase 3	Homo sapiens	102-111
22101335-4	2011	Knockdown experiments and knockout cells excluded a role of caspase-8 in curcumin-induced caspase-3 activation.	Curcumin	73-81	caspase 3	Homo sapiens	90-99
22101335-5	2011	In contrast, Apaf-1 deficiency or silencing inhibited the activity of caspase-3, pointing to a requisite role of Apaf-1 in curcumin-induced apoptotic cell death.	Curcumin	123-131	caspase 3	Homo sapiens	70-79
22101335-5	2011	In contrast, Apaf-1 deficiency or silencing inhibited the activity of caspase-3, pointing to a requisite role of Apaf-1 in curcumin-induced apoptotic cell death.	Curcumin	123-131	apoptotic peptidase activating factor 1	Homo sapiens	13-19
22101335-6	2011	Curcumin treatment led to Apaf-1 upregulation both at the protein and mRNA levels.	Curcumin	0-8	apoptotic peptidase activating factor 1	Homo sapiens	26-32
22101335-7	2011	Cytochrome c release from mitochondria to the cytosol in curcumin-treated cells was associated with upregulation of proapoptotic proteins such as Bax, Bak, Bid, and Bim.	Curcumin	57-65	cytochrome c, somatic	Homo sapiens	0-12
22101335-7	2011	Cytochrome c release from mitochondria to the cytosol in curcumin-treated cells was associated with upregulation of proapoptotic proteins such as Bax, Bak, Bid, and Bim.	Curcumin	57-65	BCL2 associated X, apoptosis regulator	Homo sapiens	146-149
22101335-7	2011	Cytochrome c release from mitochondria to the cytosol in curcumin-treated cells was associated with upregulation of proapoptotic proteins such as Bax, Bak, Bid, and Bim.	Curcumin	57-65	BH3 interacting domain death agonist	Homo sapiens	156-159
22101335-8	2011	Crosslinking experiments demonstrated Bax oligomerization during curcumin-induced apoptosis, suggesting that induced expression of Bax, Bid, and Bim causes Bax-channel formation on the mitochondrial membrane.	Curcumin	65-73	BCL2 associated X, apoptosis regulator	Homo sapiens	38-41
22101335-8	2011	Crosslinking experiments demonstrated Bax oligomerization during curcumin-induced apoptosis, suggesting that induced expression of Bax, Bid, and Bim causes Bax-channel formation on the mitochondrial membrane.	Curcumin	65-73	BCL2 associated X, apoptosis regulator	Homo sapiens	131-134
22101335-8	2011	Crosslinking experiments demonstrated Bax oligomerization during curcumin-induced apoptosis, suggesting that induced expression of Bax, Bid, and Bim causes Bax-channel formation on the mitochondrial membrane.	Curcumin	65-73	BH3 interacting domain death agonist	Homo sapiens	136-139
22101335-8	2011	Crosslinking experiments demonstrated Bax oligomerization during curcumin-induced apoptosis, suggesting that induced expression of Bax, Bid, and Bim causes Bax-channel formation on the mitochondrial membrane.	Curcumin	65-73	BCL2 associated X, apoptosis regulator	Homo sapiens	131-134
22101335-10	2011	Importantly, p21-deficiency resulted in reduced expression of Apaf-1 during curcumin treatment, indicating a requirement of p21 in Apaf-1 dependent caspase activation and apoptosis.	Curcumin	76-84	apoptotic peptidase activating factor 1	Homo sapiens	62-68
22101335-10	2011	Importantly, p21-deficiency resulted in reduced expression of Apaf-1 during curcumin treatment, indicating a requirement of p21 in Apaf-1 dependent caspase activation and apoptosis.	Curcumin	76-84	apoptotic peptidase activating factor 1	Homo sapiens	131-137
22101335-11	2011	Together, our findings demonstrate that Apaf-1, Bax, and p21 as novel potential targets for curcumin or curcumin-based anticancer agents.	Curcumin	92-100	apoptotic peptidase activating factor 1	Homo sapiens	40-46
22101335-11	2011	Together, our findings demonstrate that Apaf-1, Bax, and p21 as novel potential targets for curcumin or curcumin-based anticancer agents.	Curcumin	92-100	BCL2 associated X, apoptosis regulator	Homo sapiens	48-51
22101335-11	2011	Together, our findings demonstrate that Apaf-1, Bax, and p21 as novel potential targets for curcumin or curcumin-based anticancer agents.	Curcumin	104-112	apoptotic peptidase activating factor 1	Homo sapiens	40-46
22101335-11	2011	Together, our findings demonstrate that Apaf-1, Bax, and p21 as novel potential targets for curcumin or curcumin-based anticancer agents.	Curcumin	104-112	BCL2 associated X, apoptosis regulator	Homo sapiens	48-51
21887696-0	2011	Induction of apoptotic death by curcumin in human tongue squamous cell carcinoma SCC-4 cells is mediated through endoplasmic reticulum stress and mitochondria-dependent pathways.	Curcumin	32-40	MAU2 sister chromatid cohesion factor	Homo sapiens	81-86
21887696-2	2011	In this study, the mechanisms of cell death involved in curcumin-induced growth inhibition, including cell cycle arrest and induction of apoptosis in human tongue cancer SCC-4 cells, were investigated.	Curcumin	56-64	MAU2 sister chromatid cohesion factor	Homo sapiens	170-175
21887696-3	2011	Herein, we observed that curcumin inhibited cell growth of SCC-4 cells and induced cell death in a dose-dependent manner.	Curcumin	25-33	MAU2 sister chromatid cohesion factor	Homo sapiens	59-64
21887696-4	2011	Treatment of SCC-4 cells with curcumin caused a moderate and promoted the G(2) /M phase arrest, which was accompanied with decreases in cyclin B/CDK1 and CDC25C protein levels.	Curcumin	30-38	MAU2 sister chromatid cohesion factor	Homo sapiens	13-18
21887696-5	2011	Moreover, curcumin significantly induced apoptosis of SCC-4 cells with a decrease of the Bcl-2 level, reduction of mitochondrial membrane potential (DeltaPsi(m) ), and promoted the active forms of caspase-3.	Curcumin	10-18	MAU2 sister chromatid cohesion factor	Homo sapiens	54-59
21887696-5	2011	Moreover, curcumin significantly induced apoptosis of SCC-4 cells with a decrease of the Bcl-2 level, reduction of mitochondrial membrane potential (DeltaPsi(m) ), and promoted the active forms of caspase-3.	Curcumin	10-18	BCL2 apoptosis regulator	Homo sapiens	89-94
21887696-5	2011	Moreover, curcumin significantly induced apoptosis of SCC-4 cells with a decrease of the Bcl-2 level, reduction of mitochondrial membrane potential (DeltaPsi(m) ), and promoted the active forms of caspase-3.	Curcumin	10-18	caspase 3	Homo sapiens	197-206
21887696-6	2011	Curcumin also promoted the releases of AIF and Endo G from the mitochondria in SCC-4 cells by using confocal laser microscope.	Curcumin	0-8	MAU2 sister chromatid cohesion factor	Homo sapiens	79-84
21887696-7	2011	Therefore, we suggest that curcumin induced apoptosis through a mitochondria-dependent pathway in SCC-4 cells.	Curcumin	27-35	MAU2 sister chromatid cohesion factor	Homo sapiens	98-103
21887696-8	2011	In addition, we also found that curcumin-induced apoptosis of SCC-4 cells was partly through endoplasmic reticulum stress.	Curcumin	32-40	MAU2 sister chromatid cohesion factor	Homo sapiens	62-67
21887696-9	2011	In conclusion, curcumin increased G(2) /M phase arrest and induced apoptosis through ER stress and mitochondria-dependent pathways in SCC-4 cells.	Curcumin	15-23	MAU2 sister chromatid cohesion factor	Homo sapiens	134-139
25786365-5	2011	Coenzyme Q10 nanoparticulates reduced only C-reactive protein levels, whereas curcumin nanoparticles reduced levels of C-reactive protein, interleukin-6 and tumor necrosis factor-alpha.	Curcumin	78-86	interleukin 6	Rattus norvegicus	139-184
22092562-4	2011	The cytotoxicity of V. vulnificus to HeLa cells was significantly inhibited by curcumin (at 10 or 30 muM).	Curcumin	79-87	latexin	Homo sapiens	101-104
21850703-4	2011	In phosphate buffer, the overall degradation rate constant and half-life values indicated an order of stability of PGC &gt; PSC &gt; PMC &gt; curcumin.	Curcumin	142-150	progastricsin	Homo sapiens	115-118
22058071-8	2011	Hepatic PPARalpha and LXRalpha expression was upregulated by curcumin treatment.	Curcumin	61-69	peroxisome proliferator activated receptor alpha	Mus musculus	8-17
22058071-8	2011	Hepatic PPARalpha and LXRalpha expression was upregulated by curcumin treatment.	Curcumin	61-69	nuclear receptor subfamily 1, group H, member 3	Mus musculus	22-30
21344388-0	2011	HDAC1/NFkappaB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation.	Curcumin	38-46	histone deacetylase 1	Homo sapiens	0-5
21344388-0	2011	HDAC1/NFkappaB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation.	Curcumin	38-46	nuclear factor kappa B subunit 1	Homo sapiens	6-14
21344388-5	2011	Curcumin reversed Tat-induced down-regulation of HDAC1 expression in multinuclear activation of galactosidase indicator (MAGI) cells.	Curcumin	0-8	histone deacetylase 1	Homo sapiens	49-54
21344388-6	2011	Treatment with curcumin reversed Tat-induced dissociation of HDAC1 from LTR; and curcumin caused a decline in the binding of p65/NFkappaB to LTR promoters stimulated by Tat.	Curcumin	15-23	histone deacetylase 1	Homo sapiens	61-66
21344388-6	2011	Treatment with curcumin reversed Tat-induced dissociation of HDAC1 from LTR; and curcumin caused a decline in the binding of p65/NFkappaB to LTR promoters stimulated by Tat.	Curcumin	81-89	nuclear factor kappa B subunit 1	Homo sapiens	129-137
21344388-9	2011	Collectively, our data provide new insights into understanding of the molecular mechanisms of curcumin inhibited Tat-regulated transcription, suggesting that targeting AMPK/HDAC1/NFkappaB pathway could serve as new anti-HIV-1 agents.	Curcumin	94-102	histone deacetylase 1	Homo sapiens	173-178
21344388-9	2011	Collectively, our data provide new insights into understanding of the molecular mechanisms of curcumin inhibited Tat-regulated transcription, suggesting that targeting AMPK/HDAC1/NFkappaB pathway could serve as new anti-HIV-1 agents.	Curcumin	94-102	nuclear factor kappa B subunit 1	Homo sapiens	179-187
22060292-5	2011	Immunocytochemistry and Western blot analysis showed that curcumin suppressed the localization of transcription factor GATA-4 in the nucleus.	Curcumin	58-66	GATA binding protein 4	Rattus norvegicus	119-125
22060292-7	2011	CONCLUSIONS: These findings suggest that curcumin reduces the hypertrophic marker gene expression by inhibiting nuclear localization and DNA binding activity of GATA-4.	Curcumin	41-49	GATA binding protein 4	Rattus norvegicus	161-167
21695461-5	2011	Enzyme-linked immunosorbent assay (ELISA) showed that curcumin suppressed proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and interleukin (IL)-4 production in Con A-injected mice.	Curcumin	54-62	tumor necrosis factor	Mus musculus	108-141
21695461-5	2011	Enzyme-linked immunosorbent assay (ELISA) showed that curcumin suppressed proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and interleukin (IL)-4 production in Con A-injected mice.	Curcumin	54-62	interferon gamma	Mus musculus	143-165
21925163-8	2011	To conclude, curcumin enhances antioxidants, and decreases iNOS and NF-kappaB, thereby protecting the cells against oxidative stress induced by gentamicin.	Curcumin	13-21	nitric oxide synthase 2	Rattus norvegicus	59-63
21885917-0	2011	HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition.	Curcumin	11-19	signal transducer and activator of transcription 3	Homo sapiens	117-122
21925163-0	2011	Ameliorative effects of curcumin against renal injuries mediated by inducible nitric oxide synthase and nuclear factor kappa B during gentamicin-induced toxicity in Wistar rats.	Curcumin	24-32	nitric oxide synthase 2	Rattus norvegicus	68-99
22126332-5	2011	METHODS: We investigated the effects of curcumin administration to bleomycin stimulated C57BL/6 mice and human fetal lung fibroblasts (HFL-1) on the expression of cathepsins K and L which have been implicated in matrix degradation, TGF-beta1 modulation, and apoptosis.	Curcumin	40-48	transforming growth factor beta 1	Homo sapiens	232-241
22126332-8	2011	RESULTS: Collagen deposition in lungs was decreased by 17-28% after curcumin treatment which was accompanied by increased expression levels of cathepsins L (25%-39%) and K (41%-76%) and a 30% decrease in TGF-beta1 expression.	Curcumin	68-76	transforming growth factor beta 1	Homo sapiens	204-213
22113199-3	2011	Using human lens epithelial cells (hLECs) and Prdx6-deficient cells, we show the evidence that curcumin protects cells by upregulating Prdx6 transcription via invoking specificity protein 1 (Sp1) activity against proapoptotic stimuli.	Curcumin	95-103	Sp1 transcription factor	Homo sapiens	168-189
21986579-15	2011	CONCLUSION: The results suggest that the combination of MMC and curcumin inhibits MCF-7 cell proliferation and cell cycle progression in vitro and in vivo via the p38 MAPK pathway.	Curcumin	64-72	mitogen-activated protein kinase 14	Homo sapiens	163-166
21787756-0	2011	Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation.	Curcumin	20-28	nuclear factor, erythroid derived 2, like 2	Mus musculus	89-93
21975067-0	2011	Binding of isoxazole and pyrazole derivatives of curcumin with the activator binding domain of novel protein kinase C.	Curcumin	49-57	proline rich transmembrane protein 2	Homo sapiens	101-117
21975067-7	2011	To investigate the role of the carbonyl and hydroxyl groups of curcumin in PKC binding and to develop curcumin derivatives as effective PKC modulators, we synthesized several isoxazole and pyrazole derivatives of curcumin (2-6), characterized their absorption and fluorescence properties, and studied their interaction with the activator-binding second cysteine-rich C1B subdomain of PKCdelta, PKCepsilon and PKCtheta.	Curcumin	63-71	proline rich transmembrane protein 2	Homo sapiens	75-78
21975067-12	2011	The present result shows that isoxazole and pyrazole derivatives bind to the activator binding site of novel PKCs and both carbonyl and hydroxy groups of curcumin play roles in the binding process, depending on the nature of curcumin derivative and the PKC isotype used.	Curcumin	154-162	proline rich transmembrane protein 2	Homo sapiens	109-112
21975067-12	2011	The present result shows that isoxazole and pyrazole derivatives bind to the activator binding site of novel PKCs and both carbonyl and hydroxy groups of curcumin play roles in the binding process, depending on the nature of curcumin derivative and the PKC isotype used.	Curcumin	225-233	proline rich transmembrane protein 2	Homo sapiens	109-112
22113581-0	2011	A curcumin derivative, 2,6-bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) attenuates prostaglandin E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-gamma/LPS-stimulated macrophages.	Curcumin	2-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	147-163
22113581-0	2011	A curcumin derivative, 2,6-bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) attenuates prostaglandin E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-gamma/LPS-stimulated macrophages.	Curcumin	2-10	interferon gamma	Homo sapiens	167-176
30634242-5	2011	Furthermore, curcumin could block H2O2-mediated degradation of the protein IkappaBalpha and subsequent activation of nuclear factor kappaB, thus inhibiting the expression of its target gene cyclooxygenase 2.	Curcumin	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	75-87
22156377-4	2011	Here, we show that tetrahydrocurcumin (THC), a curcumin metabolite, regulates the oxidative stress response and aging via FOXO.	Curcumin	29-37	forkhead box, sub-group O	Drosophila melanogaster	122-126
21900746-0	2011	C086, a novel analog of curcumin, induces growth inhibition and down-regulation of NFkappaB in colon cancer cells and xenograft tumors.	Curcumin	24-32	nuclear factor kappa B subunit 1	Homo sapiens	83-91
21704149-4	2011	Notably, cell death induced by both curcumin and andrographolide was associated with decreased NFkappaB activity and a reduction in Bcl-2 and Bcl-xL expression.	Curcumin	36-44	nuclear factor kappa B subunit 1	Homo sapiens	95-103
21968503-13	2011	TGF-beta-inducible PAI-1 expression was attenuated by simvastatin and curcumin, a natural polyphenol.	Curcumin	70-78	transforming growth factor beta 1	Homo sapiens	0-8
22024084-0	2011	Curcumin attenuates insulin resistance in hepatocytes by inducing Nrf2 nuclear translocation.	Curcumin	0-8	insulin	Homo sapiens	20-27
22024084-0	2011	Curcumin attenuates insulin resistance in hepatocytes by inducing Nrf2 nuclear translocation.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
22024084-2	2011	Curcumin has been reported to induce Nrf2 nuclear translocation and upregulate the expression of numerous reactive oxygen species (ROS) detoxifying and antioxidant genes in hepatocytes.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	37-41
22024084-3	2011	This study was designed to investigate whether curcumin-induced Nrf2 nuclear translocation could reduce ROS-mediated insulin resistance in cultured LO2 hepatocytes.	Curcumin	47-55	NFE2 like bZIP transcription factor 2	Homo sapiens	64-68
22024084-3	2011	This study was designed to investigate whether curcumin-induced Nrf2 nuclear translocation could reduce ROS-mediated insulin resistance in cultured LO2 hepatocytes.	Curcumin	47-55	insulin	Homo sapiens	117-124
22199113-9	2011	RESULTS: Curcumin significantly decreased the pancreas injury and reversed the elevation of serum amylase, ALT and AST activities and TNF-alpha level in mice with AP.	Curcumin	9-17	tumor necrosis factor	Mus musculus	134-143
22024084-6	2011	Curcumin pretreatment significantly attenuated these disturbances in intracellular ROS, liver enzyme activity and significantly antagonized the lipid peroxidation, GSH depletion and insulin resistance induced by GO in LO2 hepatocytes.	Curcumin	0-8	insulin	Homo sapiens	182-189
22024084-7	2011	These effects paralleled Nrf2 nuclear translocation induced by curcumin.	Curcumin	63-71	NFE2 like bZIP transcription factor 2	Homo sapiens	25-29
22024084-8	2011	Wortmannin partially blocked curcumin-induced Nrf2 nuclear translocation.	Curcumin	29-37	NFE2 like bZIP transcription factor 2	Homo sapiens	46-50
22024084-9	2011	In addition, wortmannin prevented curcumin-induced improvements in intracellular ROS, MDA formation, GSH depletion, liver enzyme activity and insulin resistance in cultured LO2 hepatocytes.	Curcumin	34-42	insulin	Homo sapiens	142-149
22024084-10	2011	CONCLUSIONS: These findings suggest that curcumin could reduce ROS-mediated insulin resistance in hepatocytes, at least in part through nuclear translocation of Nrf2.	Curcumin	41-49	insulin	Homo sapiens	76-83
22024084-10	2011	CONCLUSIONS: These findings suggest that curcumin could reduce ROS-mediated insulin resistance in hepatocytes, at least in part through nuclear translocation of Nrf2.	Curcumin	41-49	NFE2 like bZIP transcription factor 2	Homo sapiens	161-165
21704149-4	2011	Notably, cell death induced by both curcumin and andrographolide was associated with decreased NFkappaB activity and a reduction in Bcl-2 and Bcl-xL expression.	Curcumin	36-44	BCL2 apoptosis regulator	Homo sapiens	132-137
22199113-11	2011	GW9662 could abolish the effects of curcumin on serum levels of amylase, ALT, AST, TNF-alpha, and NF-kappaB level.	Curcumin	36-44	tumor necrosis factor	Mus musculus	83-92
22199113-12	2011	INTERPRETATION &amp; CONCLUSIONS: Our results suggest that curcumin could attenuate pancreas tissue and other organ injury by inhibiting the release of inflammatory cytokine TNF-alpha.	Curcumin	59-67	tumor necrosis factor	Mus musculus	174-183
21704149-4	2011	Notably, cell death induced by both curcumin and andrographolide was associated with decreased NFkappaB activity and a reduction in Bcl-2 and Bcl-xL expression.	Curcumin	36-44	BCL2 like 1	Homo sapiens	142-148
21732406-6	2011	Curcumin generated an aberrant RANKL signal characterized by reduced expression of nuclear factor of activated T cells 2 (NFAT2) and attenuated activation of mitogen-activated protein kinases (ERK, JNK, and p38).	Curcumin	0-8	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	83-120
21732406-6	2011	Curcumin generated an aberrant RANKL signal characterized by reduced expression of nuclear factor of activated T cells 2 (NFAT2) and attenuated activation of mitogen-activated protein kinases (ERK, JNK, and p38).	Curcumin	0-8	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	122-127
21928237-7	2011	Curcumin was able to prevent the increase in Cbfa1/RUNX2 expression, but did not modify SOD-2 expression in the VSMCs cultured with the P + Ca medium.	Curcumin	0-8	RUNX family transcription factor 2	Homo sapiens	45-50
21928294-0	2011	Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells.	Curcumin	10-18	mechanistic target of rapamycin kinase	Homo sapiens	126-130
21903608-4	2011	Curcumin inhibited the growth of HEI-193 schwannoma cells in vitro and downregulated the phosphorylation of Akt and extracellular signal-regulated kinase 1/2.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	108-111
21903608-4	2011	Curcumin inhibited the growth of HEI-193 schwannoma cells in vitro and downregulated the phosphorylation of Akt and extracellular signal-regulated kinase 1/2.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	116-157
21928237-7	2011	Curcumin was able to prevent the increase in Cbfa1/RUNX2 expression, but did not modify SOD-2 expression in the VSMCs cultured with the P + Ca medium.	Curcumin	0-8	RUNX family transcription factor 2	Homo sapiens	51-56
21594647-8	2011	Curcumin activated the stress-activated p38 kinase, caspases 9 and 3, caused elevated levels of proapoptotic proteins Bax, stimulated PARP cleavage, and apoptosis.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	118-121
21594647-8	2011	Curcumin activated the stress-activated p38 kinase, caspases 9 and 3, caused elevated levels of proapoptotic proteins Bax, stimulated PARP cleavage, and apoptosis.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	134-138
21928294-0	2011	Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells.	Curcumin	10-18	AKT serine/threonine kinase 1	Homo sapiens	122-125
21936051-7	2011	Immunoblot assays revealed that a curcumin treatment (10 muM) decreased the protein abundance of AR but did not significantly affect the protein levels of HIF-1alpha and vascular endothelial growth factor, which were induced by hypoxia.	Curcumin	34-42	latexin	Homo sapiens	57-60
21936051-7	2011	Immunoblot assays revealed that a curcumin treatment (10 muM) decreased the protein abundance of AR but did not significantly affect the protein levels of HIF-1alpha and vascular endothelial growth factor, which were induced by hypoxia.	Curcumin	34-42	androgen receptor	Homo sapiens	97-99
21936051-2	2011	Curcumin, a yellow curry pigment, has been reported to enhance androgen receptor (AR) degradation.	Curcumin	0-8	androgen receptor	Homo sapiens	63-80
21936051-2	2011	Curcumin, a yellow curry pigment, has been reported to enhance androgen receptor (AR) degradation.	Curcumin	0-8	androgen receptor	Homo sapiens	82-84
22045654-7	2011	Curcumin also attenuated the expression of TGF-beta1, CTGF, osteopontin, p300 and ECM proteins such as fibronectin and type IV collagen.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	43-52
22045655-8	2011	In contrast, expressions of PDE1A, cyclin A and the epigenetic integrator ubiquitin-like containing PHD and Ring Finger domains 1 (UHRF1) and DNA methyltransferase 1 (DNMT1) were decreased by curcumin.	Curcumin	192-200	DNA methyltransferase (cytosine-5) 1	Mus musculus	142-165
21811763-0	2011	Curcumin reverses chemoresistance of human gastric cancer cells by downregulating the NF-kappaB transcription factor.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	86-95
22045655-8	2011	In contrast, expressions of PDE1A, cyclin A and the epigenetic integrator ubiquitin-like containing PHD and Ring Finger domains 1 (UHRF1) and DNA methyltransferase 1 (DNMT1) were decreased by curcumin.	Curcumin	192-200	DNA methyltransferase (cytosine-5) 1	Mus musculus	167-172
22045655-11	2011	CONCLUSION: Curcumin exerts its anti-cancer property by targeting PDE1 that inhibits melanoma cell proliferation via UHRF1, DNMT1, cyclin A, p21 and p27 regulations.	Curcumin	12-20	DNA methyltransferase (cytosine-5) 1	Mus musculus	124-129
21751034-2	2011	The present study aims to evaluate the antioxidant effects of curcumin, Nigella sativa oil (NSO) and valproate on the levels of malondialdehyde, nitric oxide, reduced glutathione and the activities of catalase, Na+, K+-ATPase and acetylcholinesterase in the hippocampus of pilocarpine-treated rats.	Curcumin	62-70	catalase	Rattus norvegicus	201-209
21811763-5	2011	Curcumin, a component of turmeric, is one such agent that has been shown to suppress NF-kappaB and increase the efficacy of chemotherapy.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	85-94
21811763-6	2011	In this study, we investigated whether curcumin can reverse chemoresistance by downregulating NF-kappaB in human gastric cancer cells.	Curcumin	39-47	nuclear factor kappa B subunit 1	Homo sapiens	94-103
21782934-8	2011	Consistent with this concept, phosphorylation of the transactivation domain of NF-kappaB was inhibited in the presence of curcumin.	Curcumin	122-130	nuclear factor kappa B subunit 1	Homo sapiens	79-88
22078453-3	2011	24 hours after curcumin is treated,  cell proliferation level and apoptosis rate are measured with MTT colorimetry and flow cytometry,  Bax,  Bcl-2 protein expression is measured with immunohistochemistry;  mRNA of Caspase-3 is tested by means of PCR.	Curcumin	15-23	caspase 3	Homo sapiens	215-224
21911894-5	2011	MATERIAL AND METHODS: The current study evaluates the in vivo role of curcumin in protecting and treating liver injury and fibrogenesis caused by carbon tetrachloride (CCl4) in rats.	Curcumin	70-78	C-C motif chemokine ligand 4	Rattus norvegicus	168-172
21911894-11	2011	Curcumin remarkably suppressed inflammation by reducing levels of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), nuclear factor-kappa B (NF-kappaB) and interleukin-6 (IL-6).	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	129-138
21911894-11	2011	Curcumin remarkably suppressed inflammation by reducing levels of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), nuclear factor-kappa B (NF-kappaB) and interleukin-6 (IL-6).	Curcumin	0-8	interleukin 6	Rattus norvegicus	180-193
21839166-7	2011	In further experiments performed in curcumin (400 mg/kg)-pretreated rats it was found that this antioxidant accumulated in kidney and activated Nrf2 at the time when K(2)Cr(2)O(7) was injected, suggesting that both direct and indirect antioxidant effects are involved in the protective effects of curcumin.	Curcumin	36-44	NFE2 like bZIP transcription factor 2	Rattus norvegicus	144-148
21896275-8	2011	p300/CBP-specific inhibitor curcumin can reverse the induction of p16(INK4a) by p33(ING1b).	Curcumin	28-36	cyclin dependent kinase inhibitor 2A	Homo sapiens	66-69
21896275-8	2011	p300/CBP-specific inhibitor curcumin can reverse the induction of p16(INK4a) by p33(ING1b).	Curcumin	28-36	cyclin dependent kinase inhibitor 2A	Homo sapiens	70-75
21911894-11	2011	Curcumin remarkably suppressed inflammation by reducing levels of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), nuclear factor-kappa B (NF-kappaB) and interleukin-6 (IL-6).	Curcumin	0-8	interleukin 6	Rattus norvegicus	195-199
21911894-11	2011	Curcumin remarkably suppressed inflammation by reducing levels of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), nuclear factor-kappa B (NF-kappaB) and interleukin-6 (IL-6).	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	100-127
21911894-13	2011	We found that oral administration of curcumin at 200 mg/kg dose not only protected against CCl4-induced hepatic injury, but also resulted in more than two-fold induction of APE1 protein expression in CCl4-induced rat group.	Curcumin	37-45	C-C motif chemokine ligand 4	Rattus norvegicus	91-95
21911894-13	2011	We found that oral administration of curcumin at 200 mg/kg dose not only protected against CCl4-induced hepatic injury, but also resulted in more than two-fold induction of APE1 protein expression in CCl4-induced rat group.	Curcumin	37-45	C-C motif chemokine ligand 4	Rattus norvegicus	200-204
21380847-6	2011	Furthermore, our results show that the hormetic effects of low levels of curcumin are achieved by virtue of it being a hormetin in terms of the induction of stress response pathways, including Nrf2 and HO-1 in human cells.	Curcumin	73-81	NFE2 like bZIP transcription factor 2	Homo sapiens	193-197
21911894-14	2011	CONCLUSIONS: It can be concluded that curcumin reduced markers of liver damage in rats treated with CCl4, with concomitant elevation in APE1 protein level indicating a possible protective effect with unknown mechanism.	Curcumin	38-46	C-C motif chemokine ligand 4	Rattus norvegicus	100-104
21627988-7	2011	In addition, the use of curcumin, an anti-cancer drug, or GRGDSP, the blocking peptide along with exogenous HABP1, inhibited such NFkappaB-dependent pathway, confirming that HABP1-induced cell migration is alpha(v)beta(3) integrin-mediated and downstream signaling by NFkappaB.	Curcumin	24-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	130-138
22005428-6	2011	Compared with pre-study values, supplementation with citrus polyphenols resulted in lower plasma AGP and haptoglobin concentrations, while that with curcumin resulted in lower plasma AGP concentration.	Curcumin	149-157	alpha-1-acid glycoprotein	Felis catus	183-186
22005428-9	2011	In contrast, IFN-gamma and IL-2 mRNA levels were lower at the end of the citrus and the curcumin supplementation, respectively.	Curcumin	88-96	interferon gamma	Felis catus	13-22
21836020-0	2011	Curcumin modulates microRNA-203-mediated regulation of the Src-Akt axis in bladder cancer.	Curcumin	0-8	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	59-62
21836020-0	2011	Curcumin modulates microRNA-203-mediated regulation of the Src-Akt axis in bladder cancer.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	63-66
21722618-4	2011	All nanoliposomes with curcumin, or the curcumin derivative, were able to inhibit the formation of fibrillar and/or oligomeric Abeta in vitro.	Curcumin	23-31	amyloid beta precursor protein	Homo sapiens	127-132
21762689-7	2011	In addition, curcumin down-regulated the expressions of Bcl-2 and procaspase-3 and increased the production of reactive oxygen species in ENU1564 cells.	Curcumin	13-21	B cell leukemia/lymphoma 2	Mus musculus	56-61
21781008-4	2011	The results showed that curcumin significantly suppressed the myocardial protein expression of inducible nitric oxide synthase (iNOS) and the catalytic subunit of nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase.	Curcumin	24-32	nitric oxide synthase 2	Rattus norvegicus	95-126
21781008-4	2011	The results showed that curcumin significantly suppressed the myocardial protein expression of inducible nitric oxide synthase (iNOS) and the catalytic subunit of nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase.	Curcumin	24-32	nitric oxide synthase 2	Rattus norvegicus	128-132
21499987-3	2011	Data from our and other laboratories have previously demonstrated that curcumin, the yellow pigment of curry, strongly induces heme-oxygenase-1 (HO-1) expression and activity in different brain cells via the activation of heterodimers of NF-E2-related factors 2 (Nrf2)/antioxidant responsive element (ARE) pathway.	Curcumin	71-79	NFE2 like bZIP transcription factor 2	Homo sapiens	238-261
21499987-3	2011	Data from our and other laboratories have previously demonstrated that curcumin, the yellow pigment of curry, strongly induces heme-oxygenase-1 (HO-1) expression and activity in different brain cells via the activation of heterodimers of NF-E2-related factors 2 (Nrf2)/antioxidant responsive element (ARE) pathway.	Curcumin	71-79	NFE2 like bZIP transcription factor 2	Homo sapiens	263-267
21658472-6	2011	The permeability of a tritiated curcumin derivative was enhanced after its entrapment into ApoE-NLs, in particular those functionalized with the dimer (+83% with respect to free drug, P &lt; 0.01).	Curcumin	32-40	apolipoprotein E	Rattus norvegicus	91-95
21722618-4	2011	All nanoliposomes with curcumin, or the curcumin derivative, were able to inhibit the formation of fibrillar and/or oligomeric Abeta in vitro.	Curcumin	40-48	amyloid beta precursor protein	Homo sapiens	127-132
21726543-3	2011	Further, mitogen and antigen-stimulated cytokine (IL-2, IL-4, IL-6 and IFN-gamma) secretion by T cells was also abrogated by curcumin and DiMC.	Curcumin	125-133	interleukin 2	Homo sapiens	50-54
21697760-5	2011	Curcumin, NLE, and RSE significantly inhibited both constitutive and RT-induced NF-kappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	80-89
21750867-7	2011	Results indicated that catalase protein expression increased in curcumin treated-Alpha3 and Alpha5 cell lines.	Curcumin	64-72	catalase	Homo sapiens	23-31
21726543-3	2011	Further, mitogen and antigen-stimulated cytokine (IL-2, IL-4, IL-6 and IFN-gamma) secretion by T cells was also abrogated by curcumin and DiMC.	Curcumin	125-133	interleukin 4	Homo sapiens	56-60
21726543-3	2011	Further, mitogen and antigen-stimulated cytokine (IL-2, IL-4, IL-6 and IFN-gamma) secretion by T cells was also abrogated by curcumin and DiMC.	Curcumin	125-133	interleukin 6	Homo sapiens	62-66
21726543-3	2011	Further, mitogen and antigen-stimulated cytokine (IL-2, IL-4, IL-6 and IFN-gamma) secretion by T cells was also abrogated by curcumin and DiMC.	Curcumin	125-133	interferon gamma	Homo sapiens	71-80
21810436-0	2011	Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	84-90
21821700-8	2011	Significant reduction of IL-8 levels (P &lt; 0.05) was seen in post-curcumin samples from patients with dental caries.	Curcumin	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
21821700-9	2011	Although there was reduced IL-8 expression in 8 of 21 post-curcumin samples of HNSCC patients, the data did not reach statistical significance.	Curcumin	59-67	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
21325634-6	2011	First, all CCA cells exhibited constitutively active nuclear factor (NF)-kappaB, and treatment with curcumin abolished this activation as indicated by DNA binding, nuclear translocation and p65 phosphorylation.	Curcumin	100-108	nuclear factor kappa B subunit 1	Homo sapiens	53-79
21810436-5	2011	Exposure of two human non-small lung cancer (NSCLC) cell lines (A549 and H1975) to curcumin could suppress MMC-induced MKK1/2-ERK1/2 signal activation and Rad51 protein expression.	Curcumin	83-91	mitogen-activated protein kinase 3	Homo sapiens	126-132
21810436-6	2011	Enhancement of ERK1/2 activation by constitutively active MKK1/2 (MKK1/2-CA) increased Rad51 protein levels in curcumin and MMC co-treated human lung cells.	Curcumin	111-119	mitogen-activated protein kinase 3	Homo sapiens	15-21
21810436-7	2011	Moreover, the synergistic cytotoxic effect induced by curcumin combined with MMC was decreased by MKK1-CA-mediated enhancement of ERK1/2 activation by a significant degree.	Curcumin	54-62	mitogen-activated protein kinase 3	Homo sapiens	130-136
21810436-8	2011	In contrast, MKK1/2 inhibitor, U0126 was shown to augment the cytotoxicity of curcumin and MMC through downregulation of ERK1/2 activation and Rad51 expression.	Curcumin	78-86	mitogen-activated protein kinase 3	Homo sapiens	121-127
21294671-2	2011	MATERIALS AND METHOD: Curcumin was administered at doses of 3, 3.75, 4.50 and 5.25 muM in PE/CA-PJ15 oral squamous cell carcinoma cultures irradiated with different doses (1, 2.5 and 5 Gy), followed by evaluation of the effects upon cell viability after 24, 48 and 72 h, based on the MTT colorimetric test.	Curcumin	22-30	latexin	Homo sapiens	83-86
21294671-4	2011	The curcumin concentration at which the inhibition of cell viability proved maximum was 5.25 muM, with statistically significant differences for 24 h (p = 0.002), 48 h (p &lt; 0.001) and 72 h of incubation (p &lt; 0.001).	Curcumin	4-12	latexin	Homo sapiens	93-96
21294671-5	2011	In contrast, the combination of curcumin and irradiation exerted a synergic effect-the greatest effects in relation to cell viability being recorded with a curcumin concentration of 3.75 muM and 5 Gy of irradiation, in the studied cell line.	Curcumin	32-40	latexin	Homo sapiens	187-190
21294671-5	2011	In contrast, the combination of curcumin and irradiation exerted a synergic effect-the greatest effects in relation to cell viability being recorded with a curcumin concentration of 3.75 muM and 5 Gy of irradiation, in the studied cell line.	Curcumin	156-164	latexin	Homo sapiens	187-190
21741352-0	2011	Curcumin modulates PKCalpha activity by a membrane-dependent effect.	Curcumin	0-8	protein kinase C alpha	Homo sapiens	19-27
21741352-1	2011	Curcumin modulates the activity of protein kinase Calpha (PKCalpha) when assayed in the presence of vesicles including phosphatidylcholine, phosphatidylserine and diacylglycerol.	Curcumin	0-8	protein kinase C alpha	Homo sapiens	35-56
21741352-1	2011	Curcumin modulates the activity of protein kinase Calpha (PKCalpha) when assayed in the presence of vesicles including phosphatidylcholine, phosphatidylserine and diacylglycerol.	Curcumin	0-8	protein kinase C alpha	Homo sapiens	58-66
21741352-2	2011	Increasing concentrations of curcumin progressively increased PKCalpha activity at concentrations lower than 20muM, but at higher concentrations of curcumin the activity decreased although, at concentrations of curcumin of up to 100muM the activity was always higher than the basal one (in the absence of curcumin).	Curcumin	29-37	protein kinase C alpha	Homo sapiens	62-70
21741352-6	2011	The pattern of binding of PKCalpha to membrane vesicles as a function of curcumin concentration closely correlated with the pattern of activating effect.	Curcumin	73-81	protein kinase C alpha	Homo sapiens	26-34
21741352-7	2011	It was concluded that the effect of curcumin on PKCalpha activity was related to its effect on the membrane, which may modulate the binding of the enzyme to the membrane.	Curcumin	36-44	protein kinase C alpha	Homo sapiens	48-56
21325634-7	2011	Second, curcumin suppressed activation of signal transducer and activator of transcription-3 as indicated by decreased phosphorylation at both tyrosine(705) and serine(727) and inhibition of janus kinase-1 phosphorylation.	Curcumin	8-16	signal transducer and activator of transcription 3	Homo sapiens	42-92
21325634-7	2011	Second, curcumin suppressed activation of signal transducer and activator of transcription-3 as indicated by decreased phosphorylation at both tyrosine(705) and serine(727) and inhibition of janus kinase-1 phosphorylation.	Curcumin	8-16	Janus kinase 1	Homo sapiens	191-205
21325634-8	2011	Third, curcumin induced expression of peroxisome proliferator-activated receptor gamma.	Curcumin	7-15	peroxisome proliferator activated receptor gamma	Homo sapiens	38-86
21325634-11	2011	Sixth, curcumin inhibited expression of cell survival proteins such as B-cell lymphoma-2, B-cell leukemia protein xL, X-linked inhibitor of apoptosis protein, c-FLIP, cellular inhibitor of apoptosis protein (cIAP)-1, cIAP-2 and survivin and proteins linked to cell proliferation, such as cyclin D1 and c-Myc.	Curcumin	7-15	CASP8 and FADD like apoptosis regulator	Homo sapiens	159-165
23467256-8	2011	While in the curcumin pretreated groups, the induced P-gp and mdr1 mRNA levels gradually decreased with increasing curcumin concentrations, and the Rh-123 accumulation level was almost recovered close to the control group"s.	Curcumin	13-21	ATP binding cassette subfamily B member 1	Homo sapiens	53-57
23467256-8	2011	While in the curcumin pretreated groups, the induced P-gp and mdr1 mRNA levels gradually decreased with increasing curcumin concentrations, and the Rh-123 accumulation level was almost recovered close to the control group"s.	Curcumin	13-21	ATP binding cassette subfamily B member 1	Homo sapiens	62-66
23467256-8	2011	While in the curcumin pretreated groups, the induced P-gp and mdr1 mRNA levels gradually decreased with increasing curcumin concentrations, and the Rh-123 accumulation level was almost recovered close to the control group"s.	Curcumin	115-123	ATP binding cassette subfamily B member 1	Homo sapiens	53-57
23467256-8	2011	While in the curcumin pretreated groups, the induced P-gp and mdr1 mRNA levels gradually decreased with increasing curcumin concentrations, and the Rh-123 accumulation level was almost recovered close to the control group"s.	Curcumin	115-123	ATP binding cassette subfamily B member 1	Homo sapiens	62-66
23467256-10	2011	CONCLUSION: Our present study suggested that curcumin exhibits the novel ability to prevent the up-regulation of P-gp and its mRNA induced by ADM.	Curcumin	45-53	ATP binding cassette subfamily B member 1	Homo sapiens	113-117
21229292-8	2011	Instead, the free radical scavenger N-acetyl-L: -cysteine (NAC) completely blocked the effect on TRAIL-induced apoptosis caused by curcumin, oridonin, and PDTC.	Curcumin	131-139	TNF superfamily member 10	Homo sapiens	97-102
22362715-7	2011	Curcumin down-regulated the expression of cluster of differntiation (CD)147, matrix metalloproteinase 2, and matrix metalloproteinase 9 and inhibited the phosphorylation of epidermal growth factor receptor (EGFR), the phosphoinositilde 3-kinase (PI3K)/protein kinase B (Akt), p38 mitogen-activated protein kinase (MAPK), and p44/42MAPK in Hca-F cells.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	270-273
21616659-5	2011	We then investigated the mechanisms associated with MMC/curcumin-induced cell death by examining the effect of MMC/curcumin treatment on apoptosis, the activation of caspase-3, 8 and 9 and the expression of bcl-2 and bax.	Curcumin	56-64	BCL2 apoptosis regulator	Homo sapiens	207-212
21616659-5	2011	We then investigated the mechanisms associated with MMC/curcumin-induced cell death by examining the effect of MMC/curcumin treatment on apoptosis, the activation of caspase-3, 8 and 9 and the expression of bcl-2 and bax.	Curcumin	56-64	BCL2 associated X, apoptosis regulator	Homo sapiens	217-220
21616659-8	2011	MMC and curcumin together synergistically enhanced apoptosis in MCF-7 cells and the apoptosis most likely resulted from both the activation of caspases and modulation of bcl-2/bax expression.	Curcumin	8-16	BCL2 apoptosis regulator	Homo sapiens	170-175
21616659-8	2011	MMC and curcumin together synergistically enhanced apoptosis in MCF-7 cells and the apoptosis most likely resulted from both the activation of caspases and modulation of bcl-2/bax expression.	Curcumin	8-16	BCL2 associated X, apoptosis regulator	Homo sapiens	176-179
21229292-5	2011	SN50, curcumin, oridonin, and pyrrolidine dithiocarbamate (PDTC) all sensitized cells to TRAIL-induced apoptosis.	Curcumin	6-14	TNF superfamily member 10	Homo sapiens	89-94
22013801-13	2011	In the 1st curcumin group and the 2nd curcumin group, the protein expressions of alpha-SMA, P-Smad2, P-Smad3, and TGF-beta 1; mRNA expression levels of TGF-beta 1, TbetaRI mRNA, Col-I, and Col-III obviously decreased (P&lt;0.05, P&lt; 0.01), while the protein expressions of E-cadherin and Smad7 obviously increased (P&lt;0.05, P&lt;0.01).	Curcumin	11-19	actin alpha 2, smooth muscle, aorta	Mus musculus	81-90
21803623-6	2011	Moreover, docking analysis insinuate the synergistic action of curcumin on celecoxib-induced inhibition of COX-2 may occur allosterically, as this natural compound docks to a place different from the inhibitor binding site.	Curcumin	63-71	prostaglandin-endoperoxide synthase 2	Homo sapiens	107-112
21295946-6	2011	Curcumin decreased secretion of IL-6 (P = 0.015) and IL-1 beta (P = 0.016).	Curcumin	0-8	interleukin 6	Homo sapiens	32-36
21295946-6	2011	Curcumin decreased secretion of IL-6 (P = 0.015) and IL-1 beta (P = 0.016).	Curcumin	0-8	interleukin 1 beta	Homo sapiens	53-62
22013801-13	2011	In the 1st curcumin group and the 2nd curcumin group, the protein expressions of alpha-SMA, P-Smad2, P-Smad3, and TGF-beta 1; mRNA expression levels of TGF-beta 1, TbetaRI mRNA, Col-I, and Col-III obviously decreased (P&lt;0.05, P&lt; 0.01), while the protein expressions of E-cadherin and Smad7 obviously increased (P&lt;0.05, P&lt;0.01).	Curcumin	38-46	actin alpha 2, smooth muscle, aorta	Mus musculus	81-90
22013801-13	2011	In the 1st curcumin group and the 2nd curcumin group, the protein expressions of alpha-SMA, P-Smad2, P-Smad3, and TGF-beta 1; mRNA expression levels of TGF-beta 1, TbetaRI mRNA, Col-I, and Col-III obviously decreased (P&lt;0.05, P&lt; 0.01), while the protein expressions of E-cadherin and Smad7 obviously increased (P&lt;0.05, P&lt;0.01).	Curcumin	38-46	transforming growth factor, beta 1	Rattus norvegicus	152-162
22013801-14	2011	CONCLUSIONS: Curcumin could intervene several sites of the TGF-beta/Smads signal transduction pathway of UUO rats, inhibit the occurrence of EMT of renal tubular epithelial cells, thus attenuating the tubulo-interstitial fibrosis.	Curcumin	13-21	transforming growth factor, beta 1	Rattus norvegicus	59-67
21859497-4	2011	The oncogenic pathways inhibited by curcumin encompass the members of epidermal growth factor receptors (EGFR and erbB2), sonic hedgehog (SHH)/GLIs and Wnt/beta-catenin and downstream signaling elements such as Akt, nuclear factor-kappa B (NF-kappaB) and signal transducers and activators of transcription (STATs).	Curcumin	36-44	epidermal growth factor receptor	Homo sapiens	105-109
21859497-4	2011	The oncogenic pathways inhibited by curcumin encompass the members of epidermal growth factor receptors (EGFR and erbB2), sonic hedgehog (SHH)/GLIs and Wnt/beta-catenin and downstream signaling elements such as Akt, nuclear factor-kappa B (NF-kappaB) and signal transducers and activators of transcription (STATs).	Curcumin	36-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	114-119
21859497-4	2011	The oncogenic pathways inhibited by curcumin encompass the members of epidermal growth factor receptors (EGFR and erbB2), sonic hedgehog (SHH)/GLIs and Wnt/beta-catenin and downstream signaling elements such as Akt, nuclear factor-kappa B (NF-kappaB) and signal transducers and activators of transcription (STATs).	Curcumin	36-44	nuclear factor kappa B subunit 1	Homo sapiens	216-238
21859497-4	2011	The oncogenic pathways inhibited by curcumin encompass the members of epidermal growth factor receptors (EGFR and erbB2), sonic hedgehog (SHH)/GLIs and Wnt/beta-catenin and downstream signaling elements such as Akt, nuclear factor-kappa B (NF-kappaB) and signal transducers and activators of transcription (STATs).	Curcumin	36-44	nuclear factor kappa B subunit 1	Homo sapiens	240-249
21546578-7	2011	Inhibitors of NF-kappaB (curcumin, SN-50) attenuated TNF-alpha-induced enhancement of TRPC1 expression, store-dependent Ca(2+) influx, and COX-2-dependent PGE(2) production.	Curcumin	25-33	nuclear factor kappa B subunit 1	Homo sapiens	14-23
21669872-0	2011	Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	34-40
21669872-0	2011	Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	42-51
21669872-0	2011	Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	146-149
21669872-4	2011	Recent studies in various cell models have demonstrated that curcumin targets the NF-kappaB signaling pathway.	Curcumin	61-69	nuclear factor kappa B subunit 1	Homo sapiens	82-91
21669872-6	2011	Herein, we used an in vitro model of human tenocytes to study the mechanism of curcumin action on IL-1beta-mediated inflammatory signaling.	Curcumin	79-87	interleukin 1 beta	Homo sapiens	98-106
21669872-7	2011	Curcumin at concentrations of 5-20 mum inhibited IL-1beta-induced inflammation and apoptosis in cultures of human tenocytes.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	49-57
21669872-11	2011	Curcumin suppressed IL-1beta-induced PI-3K p85/Akt activation and its association with IKK.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	20-28
21669872-11	2011	Curcumin suppressed IL-1beta-induced PI-3K p85/Akt activation and its association with IKK.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	47-50
21669872-12	2011	These results demonstrate, for the first time, a potential role for curcumin in treating tendon inflammation through modulation of NF-kappaB signaling, which involves PI-3K/Akt and the tendon-specific transcription factor scleraxis in tenocytes.	Curcumin	68-76	nuclear factor kappa B subunit 1	Homo sapiens	131-140
21669872-12	2011	These results demonstrate, for the first time, a potential role for curcumin in treating tendon inflammation through modulation of NF-kappaB signaling, which involves PI-3K/Akt and the tendon-specific transcription factor scleraxis in tenocytes.	Curcumin	68-76	AKT serine/threonine kinase 1	Homo sapiens	173-176
21904657-4	2011	Our novel compound CDF (a synthetic analogue of curcumin), is one such multi-targeted agent with proven anti-cancer activity in vitro and in vivo.	Curcumin	48-56	interleukin 6	Homo sapiens	19-22
21546578-7	2011	Inhibitors of NF-kappaB (curcumin, SN-50) attenuated TNF-alpha-induced enhancement of TRPC1 expression, store-dependent Ca(2+) influx, and COX-2-dependent PGE(2) production.	Curcumin	25-33	tumor necrosis factor	Homo sapiens	53-62
21546578-7	2011	Inhibitors of NF-kappaB (curcumin, SN-50) attenuated TNF-alpha-induced enhancement of TRPC1 expression, store-dependent Ca(2+) influx, and COX-2-dependent PGE(2) production.	Curcumin	25-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	139-144
21347788-2	2011	However, little is known about the effect of GRP78 expression to curcumin in hepatocellular carcinoma (HCC).	Curcumin	65-73	heat shock protein family A (Hsp70) member 5	Homo sapiens	45-50
21347788-0	2011	Glucose-regulated protein 78 (GRP78) mediated the efficacy to curcumin treatment on hepatocellular carcinoma.	Curcumin	62-70	heat shock protein family A (Hsp70) member 5	Homo sapiens	0-28
21347788-0	2011	Glucose-regulated protein 78 (GRP78) mediated the efficacy to curcumin treatment on hepatocellular carcinoma.	Curcumin	62-70	heat shock protein family A (Hsp70) member 5	Homo sapiens	30-35
21347788-5	2011	RESULTS: We found that GRP78KD cells were more resistant to curcumin treatment compared with the parental cells in MTT assay.	Curcumin	60-68	heat shock protein family A (Hsp70) member 5	Homo sapiens	23-28
21347788-7	2011	Finally, we found that knocking down GRP78 causes resistance to curcumin treatment through the suppression of caspase-3 and caspase-8 expression levels.	Curcumin	64-72	heat shock protein family A (Hsp70) member 5	Homo sapiens	37-42
21347788-7	2011	Finally, we found that knocking down GRP78 causes resistance to curcumin treatment through the suppression of caspase-3 and caspase-8 expression levels.	Curcumin	64-72	caspase 3	Homo sapiens	110-119
21347788-8	2011	CONCLUSIONS: We conclude that the expression level of GRP78 may contribute to the therapeutic effect of curcumin on HCC cells.	Curcumin	104-112	heat shock protein family A (Hsp70) member 5	Homo sapiens	54-59
21354353-7	2011	Treatment with curcumin also resulted in significant reduction in serum and tissue level of TNF-alpha, IL-1beta, IL-12, IL-18 and INF-gamma that were increased by renal I/R injury (p&lt;0.05).	Curcumin	15-23	tumor necrosis factor	Rattus norvegicus	92-101
21401974-7	2011	In contrast, compared with other diets, combined FO and curcumin feeding enhanced the resolution of chronic inflammation and suppressed (P &lt; 0 05) a key inflammatory mediator, NF-kappaB, in the colon mucosa.	Curcumin	56-64	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	179-188
22448359-2	2011	Treatment with activation inhibitor NF-kappaB curcumin against the background of immunization significantly reduced disorders in meiotic maturation of oocytes, decreased the number of cells dying by necrosis in immunocompetent organs, and attenuated the inflammatory reaction.	Curcumin	46-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	36-45
21354353-7	2011	Treatment with curcumin also resulted in significant reduction in serum and tissue level of TNF-alpha, IL-1beta, IL-12, IL-18 and INF-gamma that were increased by renal I/R injury (p&lt;0.05).	Curcumin	15-23	interleukin 1 beta	Rattus norvegicus	103-111
21520062-6	2011	In addition, pretreatment with curcumin (a p300 inhibitor) or transfection with p300 siRNA blocked cPLA(2) expression and PGE(2) synthesis induced by TNF-alpha.	Curcumin	31-39	tumor necrosis factor	Homo sapiens	150-159
21617861-0	2011	Apoptotic death in curcumin-treated NPC-TW 076 human nasopharyngeal carcinoma cells is mediated through the ROS, mitochondrial depolarization and caspase-3-dependent signaling responses.	Curcumin	19-27	caspase 3	Homo sapiens	146-155
21617861-5	2011	The results indicated that curcumin-induced G2/M phase arrest was associated with a marked decrease in the protein expression of cyclin A, cyclin B and cyclin-dependent kinase 1 (Cdk1).	Curcumin	27-35	cyclin A2	Homo sapiens	129-137
21617861-6	2011	Curcumin-induced apoptosis was accompanied with upregulation of the protein expression of Bax and downregulation of the protein levels of Bcl-2, resulting in dysfunction of mitochondria and subsequently led to cytochrome c release and sequential activation of caspase-9 and caspase-3 in NPC-TW 076 cells in a time-dependent manner.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	90-93
21617861-6	2011	Curcumin-induced apoptosis was accompanied with upregulation of the protein expression of Bax and downregulation of the protein levels of Bcl-2, resulting in dysfunction of mitochondria and subsequently led to cytochrome c release and sequential activation of caspase-9 and caspase-3 in NPC-TW 076 cells in a time-dependent manner.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	138-143
21617861-6	2011	Curcumin-induced apoptosis was accompanied with upregulation of the protein expression of Bax and downregulation of the protein levels of Bcl-2, resulting in dysfunction of mitochondria and subsequently led to cytochrome c release and sequential activation of caspase-9 and caspase-3 in NPC-TW 076 cells in a time-dependent manner.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	210-222
21617861-6	2011	Curcumin-induced apoptosis was accompanied with upregulation of the protein expression of Bax and downregulation of the protein levels of Bcl-2, resulting in dysfunction of mitochondria and subsequently led to cytochrome c release and sequential activation of caspase-9 and caspase-3 in NPC-TW 076 cells in a time-dependent manner.	Curcumin	0-8	caspase 3	Homo sapiens	274-283
21617861-7	2011	These findings revealed that mitochondria, AIF caspase-3- dependent pathways play a vital role in curcumin-induced G2/M phase arrest and apoptosis of NPC-TW 076 cells in vitro.	Curcumin	98-106	caspase 3	Homo sapiens	47-56
21658388-0	2011	Inhibitory mechanism of pure curcumin on Wilms" tumor 1 (WT1) gene expression through the PKCalpha signaling pathway in leukemic K562 cells.	Curcumin	29-37	WT1 transcription factor	Homo sapiens	41-55
21699455-7	2011	Curcumin-ND decreased cyclin D1, pAkt, pIkappaBalpha, and Bcl(2) protein.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	58-63
21823017-0	2011	Anti-tumor activity of curcumin against androgen-independent prostate cancer cells via inhibition of NF-kappaB and AP-1 pathway in vitro.	Curcumin	23-31	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	115-119
21823017-4	2011	A luciferase reporter gene assay was used to determine the effects of curcumin on the activities of intracellular NF-kappaB and AP-1 signaling pathways.	Curcumin	70-78	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	128-132
21823017-8	2011	The results of the luciferase assay revealed that curcumin selectively inhibited the activities of the NF-kappaB and AP-1 signaling pathways in PC-3 cells significantly.	Curcumin	50-58	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	117-121
21823017-9	2011	It was suggested that curcumin could exert anti-tumor activity against androgen-independent prostate cancer cells in vitro by inhibiting cellular proliferation and inducing apoptosis, which was probably contributed to the inhibition of transcription factors NF-kappaB and AP-1.	Curcumin	22-30	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	272-276
21658388-0	2011	Inhibitory mechanism of pure curcumin on Wilms" tumor 1 (WT1) gene expression through the PKCalpha signaling pathway in leukemic K562 cells.	Curcumin	29-37	WT1 transcription factor	Homo sapiens	57-60
21658388-0	2011	Inhibitory mechanism of pure curcumin on Wilms" tumor 1 (WT1) gene expression through the PKCalpha signaling pathway in leukemic K562 cells.	Curcumin	29-37	protein kinase C alpha	Homo sapiens	90-98
21658388-1	2011	The aim of this study was to investigate the inhibitory mechanism of pure curcumin on WT1 expression in leukemic K562 cells.	Curcumin	74-82	WT1 transcription factor	Homo sapiens	86-89
21658388-2	2011	Pure curcumin suppressed WT1 expression, independent of effects on protein degradation or WT1 mRNA stability.	Curcumin	5-13	WT1 transcription factor	Homo sapiens	25-28
21658388-3	2011	Chromatin immunoprecipitation and reporter gene assays indicate that pure curcumin treatment attenuates WT1 auto-regulation.	Curcumin	74-82	WT1 transcription factor	Homo sapiens	104-107
21658388-4	2011	Interestingly, PKCalpha inhibition mimicks the repressive effects of pure curcumin in K562 cells.	Curcumin	74-82	protein kinase C alpha	Homo sapiens	15-23
21658388-5	2011	Conversely, myristoylated PKCalpha over-expression increased WT1 expression and reversed the inhibitory effect of pure curcumin.	Curcumin	119-127	protein kinase C alpha	Homo sapiens	26-34
21658388-6	2011	Our study indicates that pure curcumin attenuates WT1 auto-regulatory function through inhibition of PKCalpha signaling in K562 cells.	Curcumin	30-38	WT1 transcription factor	Homo sapiens	50-53
21658388-6	2011	Our study indicates that pure curcumin attenuates WT1 auto-regulatory function through inhibition of PKCalpha signaling in K562 cells.	Curcumin	30-38	protein kinase C alpha	Homo sapiens	101-109
21441077-0	2011	Curcumin and genistein additively potentiate G551D-CFTR.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	51-55
21317920-4	2011	We have previously shown that curcumin, a natural polyphenol, enhances paclitaxel-induced cytotoxicity in vitro through downregulation of nuclear factor (NF)-kappaB and Akt pathways.	Curcumin	30-38	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	138-164
21317920-4	2011	We have previously shown that curcumin, a natural polyphenol, enhances paclitaxel-induced cytotoxicity in vitro through downregulation of nuclear factor (NF)-kappaB and Akt pathways.	Curcumin	30-38	thymoma viral proto-oncogene 1	Mus musculus	169-172
21317920-8	2011	The results suggest that a suboptimal concentration of curcumin augments the antitumor action of paclitaxel by downregulating the activation and downstream signaling of antiapoptotic factors and survival signals such as NF-kappaB, Akt and mitogen-activated protein kinases that have significant roles in proliferation, survival, angiogenesis and metastasis.	Curcumin	55-63	thymoma viral proto-oncogene 1	Mus musculus	231-234
21694723-2	2011	To date, whether STAT3 is activated and the effects of STAT3 inhibition by a newly developed curcumin analogue, GO-Y030, in colon cancer stem cells are still unknown.	Curcumin	93-101	signal transducer and activator of transcription 3	Homo sapiens	55-60
21694723-4	2011	The levels of STAT3 phosphorylation and the effects of STAT3 inhibition by a newly developed curcumin analogue, GO-Y030, that targets STAT3 in colon cancer stem cells were examined.	Curcumin	93-101	signal transducer and activator of transcription 3	Homo sapiens	55-60
21694723-4	2011	The levels of STAT3 phosphorylation and the effects of STAT3 inhibition by a newly developed curcumin analogue, GO-Y030, that targets STAT3 in colon cancer stem cells were examined.	Curcumin	93-101	signal transducer and activator of transcription 3	Homo sapiens	55-60
21694723-6	2011	GO-Y030 and curcumin inhibited STAT3 phosphorylation, cell viability, tumoursphere formation in colon cancer stem cells.	Curcumin	12-20	signal transducer and activator of transcription 3	Homo sapiens	31-36
21514701-11	2011	Compound 1b is well fitted in the active site of ALR2, binding to the ALR2 enzyme in a similar way to curcumin.	Curcumin	102-110	aldo-keto reductase family 1 member B	Homo sapiens	49-53
21545828-6	2011	Furthermore, curcumin pretreatment increased liver HO-1 (2.4-fold, p=0.001), but reduced NOS-2 (4.1-fold, p=0.01) expressions.	Curcumin	13-21	nitric oxide synthase 2	Rattus norvegicus	89-94
20839263-5	2011	Curcumin in combination with oxaliplatin was able to decrease proliferative capacity of oxaliplatin-resistant p53 wildtype and p53(-/-) cell lines more effectively than oxaliplatin alone.	Curcumin	0-8	tumor protein p53	Homo sapiens	110-113
20839263-5	2011	Curcumin in combination with oxaliplatin was able to decrease proliferative capacity of oxaliplatin-resistant p53 wildtype and p53(-/-) cell lines more effectively than oxaliplatin alone.	Curcumin	0-8	tumor protein p53	Homo sapiens	127-130
20643202-10	2011	Curcumin stabilized IkappaBalpha and inhibited nuclear translocation of p65 and p50 in LPS-activated Raw264.7 cells, and curcumin-treated mice showed reduced nuclear translocation of p65 in lung tissue.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	20-32
20643202-10	2011	Curcumin stabilized IkappaBalpha and inhibited nuclear translocation of p65 and p50 in LPS-activated Raw264.7 cells, and curcumin-treated mice showed reduced nuclear translocation of p65 in lung tissue.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	80-83
21441077-5	2011	RESULTS: Curcumin increased G551D-CFTR whole-cell and single-channel currents less than genistein did at their maximally effective concentrations.	Curcumin	9-17	CF transmembrane conductance regulator	Homo sapiens	34-38
21441077-6	2011	However, curcumin further increased the channel activity of G551D-CFTR that had been already maximally potentiated by genistein, up to ~50% of the WT-CFTR level.	Curcumin	9-17	CF transmembrane conductance regulator	Homo sapiens	66-70
21441077-6	2011	However, curcumin further increased the channel activity of G551D-CFTR that had been already maximally potentiated by genistein, up to ~50% of the WT-CFTR level.	Curcumin	9-17	CF transmembrane conductance regulator	Homo sapiens	150-154
21441077-7	2011	In addition, the combined application of genistein and curcumin over a lower concentration range synergistically rescued the gating defect of G551D-CFTR.	Curcumin	55-63	CF transmembrane conductance regulator	Homo sapiens	148-152
21441077-8	2011	CONCLUSIONS: The additive effects between curcumin and genistein not only support the hypothesis that multiple mechanisms are involved in the action of CFTR potentiators, but also pose pharmaceutical implications in the development of drugs for CF pharmacotherapy.	Curcumin	42-50	CF transmembrane conductance regulator	Homo sapiens	152-156
21529317-4	2011	RANTES and inducible nitric oxide synthase expression as well as RANTES-positive astrocytes were all induced by injury accompanied by the elevation of lipid peroxidation, and attenuated by the curcumin treatment.	Curcumin	193-201	nitric oxide synthase 2	Rattus norvegicus	11-42
21538854-4	2011	In addition, we demonstrated a relationship between curcumin treatment and the expression of VEGF, EGFR, ERK2, and Cyclin A at the transcriptional and translational levels.	Curcumin	52-60	mitogen-activated protein kinase 1	Mus musculus	105-109
20227862-7	2011	Curcumin up-regulated expression of phosphorylated AMP-activated protein kinase (AMPK), CD36, and carnitine palmitoyl transferase 1, but down-regulated expression of pyruvate dehydrogenase 4 and phosphorylated glycogen synthase (GS) in both in vivo and in vitro studies.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	81-85
20227862-9	2011	The effects of curcumin on these enzymes except for GS were suppressed by AMPK inhibitor, Compound C. LKB1, an upstream kinase of AMPK, was activated by curcumin and inhibited by radicicol, an LKB1 destabilizer.	Curcumin	15-23	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	74-78
20227862-9	2011	The effects of curcumin on these enzymes except for GS were suppressed by AMPK inhibitor, Compound C. LKB1, an upstream kinase of AMPK, was activated by curcumin and inhibited by radicicol, an LKB1 destabilizer.	Curcumin	15-23	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	130-134
20227862-9	2011	The effects of curcumin on these enzymes except for GS were suppressed by AMPK inhibitor, Compound C. LKB1, an upstream kinase of AMPK, was activated by curcumin and inhibited by radicicol, an LKB1 destabilizer.	Curcumin	153-161	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	74-78
20227862-9	2011	The effects of curcumin on these enzymes except for GS were suppressed by AMPK inhibitor, Compound C. LKB1, an upstream kinase of AMPK, was activated by curcumin and inhibited by radicicol, an LKB1 destabilizer.	Curcumin	153-161	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	130-134
20227862-10	2011	CONCLUSION: Curcumin improves muscular insulin resistance by increasing oxidation of fatty acid and glucose, which is, at least in part, mediated through LKB1-AMPK pathway.	Curcumin	12-20	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	159-163
21498608-11	2011	An NF-kappaB inhibitory peptide reversed curcumin-mediated protective effect on RGC-5 cells, but did not inhibit protease levels.	Curcumin	41-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	3-12
21713389-8	2011	Curcumin proved to lower HIF-1alpha and HIF-2alpha protein levels in hypoxia.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-35
21598989-12	2011	Furthermore, our results reveal that FoxO1 protein was increased after 5gg, quercetin, curcumin and lycopene treatment.	Curcumin	87-95	forkhead box O1	Homo sapiens	37-42
21498608-12	2011	Curcumin did not inhibit protease levels in vivo, but attenuated RGC and amacrine cell loss by restoring NF-kappaB expression.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	105-114
21282301-6	2011	Garcinol and anacardic acid, inhibitors of the histone acetyl transferases CBP/p300 and PCAF, reduced basal and HDAC inhibitor-induced t-PA expression, whereas curcumin, an inhibitor of CBP/p300 only, had no effect.	Curcumin	160-168	CREB binding protein	Homo sapiens	186-194
21663638-11	2011	In addition, curcumin treatment also markedly decreased ICAM-1, MCP-1 and TGF-beta1 protein expression.	Curcumin	13-21	mast cell protease 1-like 1	Rattus norvegicus	64-69
21663638-11	2011	In addition, curcumin treatment also markedly decreased ICAM-1, MCP-1 and TGF-beta1 protein expression.	Curcumin	13-21	transforming growth factor, beta 1	Rattus norvegicus	74-83
21480667-4	2011	Studies have shown that curcumin (CUR) has a pleiotropic therapeutic effect in cancer treatment, as it is an inhibitor of nuclear factor kappa B (NFkappaB) as well as a potent downregulator of MDR transporters.	Curcumin	24-32	nuclear factor kappa B subunit 1	Homo sapiens	122-144
21480667-4	2011	Studies have shown that curcumin (CUR) has a pleiotropic therapeutic effect in cancer treatment, as it is an inhibitor of nuclear factor kappa B (NFkappaB) as well as a potent downregulator of MDR transporters.	Curcumin	24-32	nuclear factor kappa B subunit 1	Homo sapiens	146-154
21811692-2	2011	In this study, we investigated the effects of curcumin on the production of interleukin-6 (IL-6) by murine macrophage-like RAW 264.7 cells stimulated with lipopolysaccharide (LPS) from Prevotella intermedia, a major cause of inflammatory periodontal disease, and sought to determine the underlying mechanisms of action.	Curcumin	46-54	interleukin 6	Mus musculus	76-89
20815812-6	2011	Curcumin treatment reduced miR-21 promoter activity and expression in a dose-dependent manner by inhibiting AP-1 binding to the promoter, and induced the expression of the tumour suppressor Pdcd4 (programmed cell death protein 4), which is a target of miR-21.	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	108-112
20815812-10	2011	Taken together, this is the first paper to show that curcumin inhibits the transcriptional regulation of miR-21 via AP-1, suppresses cell proliferation, tumour growth, invasion and in vivo metastasis, and stabilizes the expression of the tumour suppressor Pdcd4 in colorectal cancer.	Curcumin	53-61	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-120
20945380-9	2011	Treatment of microglia with AP-1 inhibitors (Tanshinone IIA and curcumin) effectively reduced PGN-induced IL-6 expression.	Curcumin	64-72	interleukin 6	Homo sapiens	106-110
20945380-13	2011	Co-transfection with dominant negative mutant of JNK (DN-JNK), or treatment with SP600125, curcumin, or Tanshinone IIA effectively antagonized PGN-increased IL-6 transcription activity.	Curcumin	91-99	interleukin 6	Homo sapiens	157-161
21811692-0	2011	Curcumin suppresses the production of interleukin-6 in Prevotella intermedia lipopolysaccharide-activated RAW 264.7 cells.	Curcumin	0-8	interleukin 6	Mus musculus	38-51
21811692-2	2011	In this study, we investigated the effects of curcumin on the production of interleukin-6 (IL-6) by murine macrophage-like RAW 264.7 cells stimulated with lipopolysaccharide (LPS) from Prevotella intermedia, a major cause of inflammatory periodontal disease, and sought to determine the underlying mechanisms of action.	Curcumin	46-54	interleukin 6	Mus musculus	91-95
21811692-8	2011	RESULTS: Curcumin strongly suppressed the production of IL-6 at both gene transcription and translation levels in P. intermedia LPS-activated RAW 264.7 cells.	Curcumin	9-17	interleukin 6	Mus musculus	56-60
21811692-10	2011	Curcumin blocked NF-kappaB signaling through the inhibition of nuclear translocation of NF-kappaB p50 subunit.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	17-26
21811692-10	2011	Curcumin blocked NF-kappaB signaling through the inhibition of nuclear translocation of NF-kappaB p50 subunit.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-101
21811692-11	2011	Curcumin also attenuated DNA binding activity of p50 and p65 subunits and suppressed STAT1 phosphorylation.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-52
21811692-12	2011	CONCLUSIONS: Although further study is required to explore the detailed mechanism of action, curcumin may contribute to blockade of the host-destructive processes mediated by IL-6 and appears to have potential therapeutic values in the treatment of inflammatory periodontal disease.	Curcumin	93-101	interleukin 6	Mus musculus	175-179
21199667-9	2011	Real-time polymerase chain reaction was performed to assess RANTES and iNOS mRNA expression in astrocytes following curcumin treatment.	Curcumin	116-124	nitric oxide synthase 2	Rattus norvegicus	71-75
21556896-0	2011	Kinase gene expression and subcellular protein expression pattern of protein kinase C isoforms in curcumin-treated human hepatocellular carcinoma Hep 3B cells.	Curcumin	98-106	proline rich transmembrane protein 2	Homo sapiens	69-85
21556896-3	2011	In this study, PKC mRNA expression was significantly inhibited in curcumin-treated human hepatocellular carcinoma (HCC) Hep 3B cells identified using a kinase cDNA microarray.	Curcumin	66-74	proline rich transmembrane protein 2	Homo sapiens	15-18
21199667-16	2011	We found that curcumin inhibited iNOS expression in primary cultured astrocytes in non-stressed condition.	Curcumin	14-22	nitric oxide synthase 2	Rattus norvegicus	33-37
21556896-5	2011	In cytosolic fraction, the expression of PKC-alpha was totally inhibited by curcumin.	Curcumin	76-84	protein kinase C alpha	Homo sapiens	41-50
21245202-8	2011	In contrast, curcumin, myrcene and cineole significantly increased GSH, CAT, GSH-Px and CuZn-SOD levels but decreased formation of TBARS.	Curcumin	13-21	catalase	Rattus norvegicus	72-75
21556896-8	2011	In summary, the changes in expression and distribution of subcellular PKC isoforms in curcumin-treated Hep 3B cells suggest possible PKC-associated anti-tumor mechanisms of curcumin and provide alternative therapies for human HCC.	Curcumin	86-94	proline rich transmembrane protein 2	Homo sapiens	70-73
21556896-8	2011	In summary, the changes in expression and distribution of subcellular PKC isoforms in curcumin-treated Hep 3B cells suggest possible PKC-associated anti-tumor mechanisms of curcumin and provide alternative therapies for human HCC.	Curcumin	86-94	proline rich transmembrane protein 2	Homo sapiens	133-136
21556896-8	2011	In summary, the changes in expression and distribution of subcellular PKC isoforms in curcumin-treated Hep 3B cells suggest possible PKC-associated anti-tumor mechanisms of curcumin and provide alternative therapies for human HCC.	Curcumin	173-181	proline rich transmembrane protein 2	Homo sapiens	70-73
21556896-8	2011	In summary, the changes in expression and distribution of subcellular PKC isoforms in curcumin-treated Hep 3B cells suggest possible PKC-associated anti-tumor mechanisms of curcumin and provide alternative therapies for human HCC.	Curcumin	173-181	proline rich transmembrane protein 2	Homo sapiens	133-136
21245202-8	2011	In contrast, curcumin, myrcene and cineole significantly increased GSH, CAT, GSH-Px and CuZn-SOD levels but decreased formation of TBARS.	Curcumin	13-21	superoxide dismutase 1	Rattus norvegicus	88-96
29147235-0	2011	Curcumin Induces Apoptosis in EJ Bladder Cancer Cells via Modulating C-Myc and PI3K/Akt Signaling Pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	84-87
29147235-6	2011	Immunoblot showed that curcumin increased expression levels of c-myc and inhibited the activation of PI3K/Akt pathway in a time-dependent manner in EJ cells.	Curcumin	23-31	AKT serine/threonine kinase 1	Homo sapiens	106-109
29147235-8	2011	Conclusions: These findings establish a mechanistic linkup or interaction between c-myc, Bax, Bad, Bcl-2, caspase cascades, PI3K/Akt pathway and curcumin- induced apoptosis of EJ cells, suggesting that c-myc and PI3K/Akt signaling pathway play important roles in curcumin-induced apoptosis of EJ bladder cancer cells.	Curcumin	145-153	BCL2 associated X, apoptosis regulator	Homo sapiens	89-92
29147235-8	2011	Conclusions: These findings establish a mechanistic linkup or interaction between c-myc, Bax, Bad, Bcl-2, caspase cascades, PI3K/Akt pathway and curcumin- induced apoptosis of EJ cells, suggesting that c-myc and PI3K/Akt signaling pathway play important roles in curcumin-induced apoptosis of EJ bladder cancer cells.	Curcumin	145-153	BCL2 apoptosis regulator	Homo sapiens	99-104
29147235-8	2011	Conclusions: These findings establish a mechanistic linkup or interaction between c-myc, Bax, Bad, Bcl-2, caspase cascades, PI3K/Akt pathway and curcumin- induced apoptosis of EJ cells, suggesting that c-myc and PI3K/Akt signaling pathway play important roles in curcumin-induced apoptosis of EJ bladder cancer cells.	Curcumin	145-153	AKT serine/threonine kinase 1	Homo sapiens	129-132
29147235-8	2011	Conclusions: These findings establish a mechanistic linkup or interaction between c-myc, Bax, Bad, Bcl-2, caspase cascades, PI3K/Akt pathway and curcumin- induced apoptosis of EJ cells, suggesting that c-myc and PI3K/Akt signaling pathway play important roles in curcumin-induced apoptosis of EJ bladder cancer cells.	Curcumin	145-153	AKT serine/threonine kinase 1	Homo sapiens	217-220
21729550-7	2011	And RT-PCR showed, as compared with curcumin or bortezomib group, there was mRNA expression decrease of BCL-2, cyclin D1 but increase of BAX in combined group.	Curcumin	36-44	BCL2 apoptosis regulator	Homo sapiens	104-109
21595920-0	2011	Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	31-36
21729550-7	2011	And RT-PCR showed, as compared with curcumin or bortezomib group, there was mRNA expression decrease of BCL-2, cyclin D1 but increase of BAX in combined group.	Curcumin	36-44	BCL2 associated X, apoptosis regulator	Homo sapiens	137-140
22053378-9	2011	The degrees of fibrosis were significantly alleviated; Compared with curcumin group, liver index and serum ALT, AST of curcumin derivative group were also significantly decreased [(4.88 +/- 0.62) vs (5.16 +/- 0.61); (69.20 +/- 27.58) vs (82.5 +/- 33.23); (158.00 +/- 39.15) vs (211.75 +/- 106.30), P &lt; 0.05]; The liver steatosis and inflammation grade were also significantly improved .The gene transcriptions of TNF alpha, NF-kappa B and HMG-CoA reductase in curcumin derivative group were significantly lower than those in curcumin and saline group (P &lt; 0.05).	Curcumin	119-127	tumor necrosis factor	Rattus norvegicus	416-425
22053378-9	2011	The degrees of fibrosis were significantly alleviated; Compared with curcumin group, liver index and serum ALT, AST of curcumin derivative group were also significantly decreased [(4.88 +/- 0.62) vs (5.16 +/- 0.61); (69.20 +/- 27.58) vs (82.5 +/- 33.23); (158.00 +/- 39.15) vs (211.75 +/- 106.30), P &lt; 0.05]; The liver steatosis and inflammation grade were also significantly improved .The gene transcriptions of TNF alpha, NF-kappa B and HMG-CoA reductase in curcumin derivative group were significantly lower than those in curcumin and saline group (P &lt; 0.05).	Curcumin	119-127	tumor necrosis factor	Rattus norvegicus	416-425
22053378-9	2011	The degrees of fibrosis were significantly alleviated; Compared with curcumin group, liver index and serum ALT, AST of curcumin derivative group were also significantly decreased [(4.88 +/- 0.62) vs (5.16 +/- 0.61); (69.20 +/- 27.58) vs (82.5 +/- 33.23); (158.00 +/- 39.15) vs (211.75 +/- 106.30), P &lt; 0.05]; The liver steatosis and inflammation grade were also significantly improved .The gene transcriptions of TNF alpha, NF-kappa B and HMG-CoA reductase in curcumin derivative group were significantly lower than those in curcumin and saline group (P &lt; 0.05).	Curcumin	119-127	tumor necrosis factor	Rattus norvegicus	416-425
21595920-0	2011	Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells.	Curcumin	0-8	CD34 molecule	Homo sapiens	87-91
21595920-0	2011	Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells.	Curcumin	0-8	CD34 molecule	Homo sapiens	146-150
21595920-4	2011	The aim of this study was to therefore to explore curcumin-induced cytotoxicity in DNR-insensitive CD34+ AML cell lines (KG1a, Kasumi-1), DNR-sensitive U937 AML cells, and primary CD34+ AML bone-marrow-derived cells.	Curcumin	50-58	CD34 molecule	Homo sapiens	99-103
21595920-4	2011	The aim of this study was to therefore to explore curcumin-induced cytotoxicity in DNR-insensitive CD34+ AML cell lines (KG1a, Kasumi-1), DNR-sensitive U937 AML cells, and primary CD34+ AML bone-marrow-derived cells.	Curcumin	50-58	CD34 molecule	Homo sapiens	180-184
21595920-13	2011	Curcumin-induced apoptosis was associated with reduced expression of both Bcl-2 mRNA and protein, subsequent loss of MMP, and activation of caspase-3 followed by PARP degradation.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	74-79
21426935-0	2011	Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells.	Curcumin	52-60	NFE2 like bZIP transcription factor 2	Homo sapiens	79-83
21595920-13	2011	Curcumin-induced apoptosis was associated with reduced expression of both Bcl-2 mRNA and protein, subsequent loss of MMP, and activation of caspase-3 followed by PARP degradation.	Curcumin	0-8	caspase 3	Homo sapiens	140-149
21426935-9	2011	Most of the PEGylated curcumin analogs strongly activate Nrf2 several folds higher than the free curcumin but copolymer 3a was identified as the most potent Nrf2 activator.	Curcumin	22-30	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
21595920-14	2011	Curcumin synergistically enhanced the cytotoxic effect of DNR in DNR-insensitive KG1a and Kasumi-1 cells, consistent with decreased Bcl-2 expression.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	132-137
21595920-16	2011	More importantly, curcumin suppressed Bcl-2 expression, selectively inhibited proliferation and synergistically enhanced the cytotoxicity of DNR in primary CD34+ AML cells, while showing limited lethality in normal CD34+ hematopoietic progenitors.	Curcumin	18-26	BCL2 apoptosis regulator	Homo sapiens	38-43
21595920-16	2011	More importantly, curcumin suppressed Bcl-2 expression, selectively inhibited proliferation and synergistically enhanced the cytotoxicity of DNR in primary CD34+ AML cells, while showing limited lethality in normal CD34+ hematopoietic progenitors.	Curcumin	18-26	CD34 molecule	Homo sapiens	156-160
21595920-16	2011	More importantly, curcumin suppressed Bcl-2 expression, selectively inhibited proliferation and synergistically enhanced the cytotoxicity of DNR in primary CD34+ AML cells, while showing limited lethality in normal CD34+ hematopoietic progenitors.	Curcumin	18-26	CD34 molecule	Homo sapiens	215-219
21595920-17	2011	CONCLUSION: Curcumin down-regulates Bcl-2 and induces apoptosis in DNR-insensitive CD34+ AML cell lines and primary CD34+ AML cells.	Curcumin	12-20	BCL2 apoptosis regulator	Homo sapiens	36-41
21595920-17	2011	CONCLUSION: Curcumin down-regulates Bcl-2 and induces apoptosis in DNR-insensitive CD34+ AML cell lines and primary CD34+ AML cells.	Curcumin	12-20	CD34 molecule	Homo sapiens	83-87
21595920-17	2011	CONCLUSION: Curcumin down-regulates Bcl-2 and induces apoptosis in DNR-insensitive CD34+ AML cell lines and primary CD34+ AML cells.	Curcumin	12-20	CD34 molecule	Homo sapiens	116-120
21349269-9	2011	On the other hand, curcumin, either alone or combined with bone marrow transplantation, blunted the pancreatic lipid-peroxidation, up-regulated activities of the antioxidant enzymes, and suppressed serum levels of TNF-alpha and IL-1beta.	Curcumin	19-27	tumor necrosis factor	Mus musculus	214-223
21345977-5	2011	To test this hypothesis, we treated Pkd1-deletion mice with diferuloylmethane (curcumin), a compound without appreciable side effects and known to modulate several pathways that are also altered in ADPKD, e.g., mammalian target of rapamycin (mTOR) and Wnt signaling.	Curcumin	60-77	mechanistic target of rapamycin kinase	Homo sapiens	211-240
21345977-5	2011	To test this hypothesis, we treated Pkd1-deletion mice with diferuloylmethane (curcumin), a compound without appreciable side effects and known to modulate several pathways that are also altered in ADPKD, e.g., mammalian target of rapamycin (mTOR) and Wnt signaling.	Curcumin	60-77	mechanistic target of rapamycin kinase	Homo sapiens	242-246
21345977-5	2011	To test this hypothesis, we treated Pkd1-deletion mice with diferuloylmethane (curcumin), a compound without appreciable side effects and known to modulate several pathways that are also altered in ADPKD, e.g., mammalian target of rapamycin (mTOR) and Wnt signaling.	Curcumin	79-87	mechanistic target of rapamycin kinase	Homo sapiens	211-240
21345977-5	2011	To test this hypothesis, we treated Pkd1-deletion mice with diferuloylmethane (curcumin), a compound without appreciable side effects and known to modulate several pathways that are also altered in ADPKD, e.g., mammalian target of rapamycin (mTOR) and Wnt signaling.	Curcumin	79-87	mechanistic target of rapamycin kinase	Homo sapiens	242-246
21345977-9	2011	Importantly, Pkd1-deletion mice that were treated with curcumin and killed at an early stage of PKD displayed improved renal histology and reduced STAT3 activation, proliferation index, cystic index, and kidney weight/body weight ratios.	Curcumin	55-63	signal transducer and activator of transcription 3	Mus musculus	147-152
21576562-1	2011	OBJECTIVE: To determine whether a novel small molecule inhibitor derived from curcumin (FLLL32) that targets signal transducer and activator of transcription (STAT) 3 would induce cytotoxic effects in STAT3-dependent head and neck squamous cell cancer (HNSCC) cells and would sensitize tumors to cisplatin.	Curcumin	78-86	signal transducer and activator of transcription 3	Homo sapiens	201-206
21506134-9	2011	Therefore, the enhanced oral bioavailability of etoposide in the presence of curcumin might be due mainly to inhibition of the P-gp efflux pump in the small intestine and possibly by reduced first-pass metabolism of etoposide in the small intestine by inhibition of CYP3A activity in rats.	Curcumin	77-85	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	266-271
21589925-9	2011	Inhibitors for MEK1/2 (PD98059), JNK (SP600125) or AP1 (curcumin) significantly inhibited MCP-1-induced amylin mRNA expression.	Curcumin	56-64	islet amyloid polypeptide	Mus musculus	104-110
21349269-9	2011	On the other hand, curcumin, either alone or combined with bone marrow transplantation, blunted the pancreatic lipid-peroxidation, up-regulated activities of the antioxidant enzymes, and suppressed serum levels of TNF-alpha and IL-1beta.	Curcumin	19-27	interleukin 1 beta	Mus musculus	228-236
21310207-6	2011	Curcumin showed an anti-hyperglycemic effect and improved insulin sensitivity, and this action may be attributed at least in part to its anti-inflammatory properties as evident by attenuating TNF-alpha levels in HFD fed rats, and its anti-lipolytic effect as evident by attenuating plasma free fatty acids.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	192-201
21295102-7	2011	Pretreatment with curcumin significantly increased DOX-induced apoptosis of cardiac muscle cells through down regulation of Bcl-2, up-regulation of caspase-8 and caspase-9.	Curcumin	18-26	BCL2, apoptosis regulator	Rattus norvegicus	124-129
21295102-7	2011	Pretreatment with curcumin significantly increased DOX-induced apoptosis of cardiac muscle cells through down regulation of Bcl-2, up-regulation of caspase-8 and caspase-9.	Curcumin	18-26	caspase 9	Rattus norvegicus	162-171
21295102-8	2011	The Bax/Bcl-2 ratio increased significantly after 1h pretreatment with curcumin.	Curcumin	71-79	BCL2, apoptosis regulator	Rattus norvegicus	8-13
21393628-9	2011	By contrast, the pan-JAK inhibitor curcumin inhibited the activity of this reporter following treatment with either IL-2 or IL-3.	Curcumin	35-43	interleukin 3	Mus musculus	124-128
21484156-0	2011	Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	54-58
21484156-3	2011	In this study, we investigated whether curcumin and resveratrol can synergistically inhibit the catabolic effects of IL-1beta, specifically the inhibition of the MAPK and subsequent apoptosis in human articular chondrocytes.	Curcumin	39-47	interleukin 1 beta	Homo sapiens	117-125
21484156-3	2011	In this study, we investigated whether curcumin and resveratrol can synergistically inhibit the catabolic effects of IL-1beta, specifically the inhibition of the MAPK and subsequent apoptosis in human articular chondrocytes.	Curcumin	39-47	mitogen-activated protein kinase 3	Homo sapiens	162-166
21484156-8	2011	Furthermore, curcumin and resveratrol inhibited IL-1beta- or U0126-induced apoptosis and downregulation of beta1-integrins and Erk1/2 in human articular chondrocytes.	Curcumin	13-21	interleukin 1 beta	Homo sapiens	48-56
21484156-8	2011	Furthermore, curcumin and resveratrol inhibited IL-1beta- or U0126-induced apoptosis and downregulation of beta1-integrins and Erk1/2 in human articular chondrocytes.	Curcumin	13-21	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	107-112
21484156-8	2011	Furthermore, curcumin and resveratrol inhibited IL-1beta- or U0126-induced apoptosis and downregulation of beta1-integrins and Erk1/2 in human articular chondrocytes.	Curcumin	13-21	mitogen-activated protein kinase 3	Homo sapiens	127-133
21443863-3	2011	Curcumin acted downstream of protein kinase C activation and intracellular Ca(2+) release to inhibit IkappaB phosphorylation, which is required for nuclear translocation of the transcription factor NFkappaB.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	198-206
21110780-3	2011	This study demonstrates that curcumin decreased the activity of IDPm, both as a purified enzyme and in cultured cells.	Curcumin	29-37	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	64-68
21110780-4	2011	It also shows that curcumin-induced apoptosis in the colon cancer cell line HCT116 is significantly enhanced by suppression of IDPm activity.	Curcumin	19-27	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	127-131
21110780-5	2011	Transfection of HCT116 cells with an IDPm small interfering RNA (siRNA) markedly decreased activity of IDPm, enhancing cellular susceptibility to curcumin-induced apoptosis, as reflected by DNA fragmentation, cellular redox status, mitochondria dysfunction and modulation of apoptotic marker proteins.	Curcumin	146-154	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	37-41
21308734-0	2011	Inhibitory effect of curcumin on oral carcinoma CAL-27 cells via suppression of Notch-1 and NF-kappaB signaling pathways.	Curcumin	21-29	notch receptor 1	Homo sapiens	80-87
21308734-0	2011	Inhibitory effect of curcumin on oral carcinoma CAL-27 cells via suppression of Notch-1 and NF-kappaB signaling pathways.	Curcumin	21-29	nuclear factor kappa B subunit 1	Homo sapiens	92-101
21308734-5	2011	For the first time, we found a significant reduction in cell viability in curcumin-treated cells, which was consistent with induction of apoptosis and also associated with down-regulation of Notch-1 and nuclear factor-kappaB (NF-kappaB).	Curcumin	74-82	notch receptor 1	Homo sapiens	191-224
21308734-5	2011	For the first time, we found a significant reduction in cell viability in curcumin-treated cells, which was consistent with induction of apoptosis and also associated with down-regulation of Notch-1 and nuclear factor-kappaB (NF-kappaB).	Curcumin	74-82	nuclear factor kappa B subunit 1	Homo sapiens	226-235
21308734-6	2011	Taken together, we conclude that the down-regulation of Notch-1 by curcumin could be an effective approach, which will cause down-regulation of NF-kappaB, resulting in the inhibition of cell growth and invasion.	Curcumin	67-75	notch receptor 1	Homo sapiens	56-63
21308734-6	2011	Taken together, we conclude that the down-regulation of Notch-1 by curcumin could be an effective approach, which will cause down-regulation of NF-kappaB, resulting in the inhibition of cell growth and invasion.	Curcumin	67-75	nuclear factor kappa B subunit 1	Homo sapiens	144-153
21308734-7	2011	These results suggest that antitumor activity of curcumin is mediated through a novel mechanism involving inactivation of Notch-1 and NF-kappaB signaling pathways.	Curcumin	49-57	notch receptor 1	Homo sapiens	122-129
21308734-7	2011	These results suggest that antitumor activity of curcumin is mediated through a novel mechanism involving inactivation of Notch-1 and NF-kappaB signaling pathways.	Curcumin	49-57	nuclear factor kappa B subunit 1	Homo sapiens	134-143
20655188-9	2011	Curcumin suppressed NF-kappaB binding and cytokine release in THP-1 cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	20-29
20655188-11	2011	Curcumin treatment also significantly reduced HAT activity, level of p300 and acetylated CBP/p300 gene expression, and induced HDAC2 expression by curcumin.	Curcumin	0-8	CREB binding protein	Homo sapiens	89-97
20655188-11	2011	Curcumin treatment also significantly reduced HAT activity, level of p300 and acetylated CBP/p300 gene expression, and induced HDAC2 expression by curcumin.	Curcumin	0-8	histone deacetylase 2	Homo sapiens	127-132
20655188-11	2011	Curcumin treatment also significantly reduced HAT activity, level of p300 and acetylated CBP/p300 gene expression, and induced HDAC2 expression by curcumin.	Curcumin	147-155	histone deacetylase 2	Homo sapiens	127-132
20655188-12	2011	These results indicate that curcumin decreases HG-induced cytokine production in monocytes via epigenetic changes involving NF-kappaB.	Curcumin	28-36	nuclear factor kappa B subunit 1	Homo sapiens	124-133
21343524-8	2011	The post-TBI dietary supplementation of the curcumin derivative normalized levels of BDNF, and its downstream effectors on synaptic plasticity (CREB, synapsin I) and neuronal signaling (CaMKII), as well as levels of oxidative stress-related molecules (SOD, Sir2).	Curcumin	44-52	sirtuin 1	Rattus norvegicus	257-261
21237271-8	2011	We further found that curcumin can reduce mutant alpha- synuclein-induced intracellular reactive oxygen species (ROS) levels, mitochondrial depolarization, cytochrome c release, and caspase-9 and caspase-3 activation.	Curcumin	22-30	caspase 9	Rattus norvegicus	182-191
21314438-7	2011	Proinflammatory cytokines, tumor necrosis factor-alpha and vascular endothelial growth factor, were elevated &gt;2-fold in the diabetic retinae, but prevented by curcumin.	Curcumin	162-170	tumor necrosis factor	Rattus norvegicus	27-54
21442412-7	2011	Curcumin interacts with specific proteins in adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells, where it suppresses several cellular proteins such as transcription factor NF-kB, STAT-3, Wnt/beta-catenin and activates PPAR-gamma, Nrf2 cell signaling pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	212-218
21442412-7	2011	Curcumin interacts with specific proteins in adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells, where it suppresses several cellular proteins such as transcription factor NF-kB, STAT-3, Wnt/beta-catenin and activates PPAR-gamma, Nrf2 cell signaling pathway.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	251-261
21442412-7	2011	Curcumin interacts with specific proteins in adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells, where it suppresses several cellular proteins such as transcription factor NF-kB, STAT-3, Wnt/beta-catenin and activates PPAR-gamma, Nrf2 cell signaling pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	263-267
21442412-8	2011	In addition, curcumin downregulates the inflammatory cytokines, resistin and leptin, and upregulates adiponectin as well as other associated proteins.	Curcumin	13-21	adiponectin, C1Q and collagen domain containing	Homo sapiens	101-112
21442412-9	2011	The interactions of curcumin with several signal transduction pathways reverse insulin resistance, hyperglycemia, hyperlipidemia, and other inflammatory symptoms associated with obesity and metabolic diseases.	Curcumin	20-28	insulin	Homo sapiens	79-86
21161336-3	2011	The current study examines whether difluorinated-curcumin (CDF), a novel analog of the dietary ingredient of curcumin, in combination with 5-fluorouracil and oxaliplatin (5-FU + Ox), the mainstay of colon cancer chemotherapeutic, would be effective in eliminating colon CSCs.	Curcumin	49-57	interleukin 6	Homo sapiens	59-62
21443800-9	2011	FLLL32 promoted loss of cell proliferation at lower concentrations than curcumin leading to caspase-3- dependent apoptosis, as evidenced by PARP cleavage and increased caspase 3/7 activity; this could be inhibited by treatment with the pan-caspase inhibitor Z-VAD-FMK.	Curcumin	72-80	caspase 3	Homo sapiens	92-101
21069514-5	2011	Bupivacaine and curcumin, two strong TREK-1 channel inhibitors, significantly increased embryonic NSC viability and proliferation while transfection of hTREK-1 decreased cell proliferation in embryonic NSCs.	Curcumin	16-24	potassium two pore domain channel subfamily K member 2	Homo sapiens	37-43
21069514-5	2011	Bupivacaine and curcumin, two strong TREK-1 channel inhibitors, significantly increased embryonic NSC viability and proliferation while transfection of hTREK-1 decreased cell proliferation in embryonic NSCs.	Curcumin	16-24	potassium two pore domain channel subfamily K member 2	Homo sapiens	152-159
21443800-0	2011	The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines.	Curcumin	10-18	signal transducer and activator of transcription 3	Homo sapiens	43-48
21443800-11	2011	CONCLUSIONS: These data demonstrate that the novel curcumin analog FLLL32 has biologic activity against OSA cell lines through inhibition of STAT3 function and expression.	Curcumin	51-59	signal transducer and activator of transcription 3	Homo sapiens	141-146
21314329-0	2011	Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin.	Curcumin	87-95	tumor protein p53	Homo sapiens	16-19
21236599-0	2011	Curcumin regulates low-linear energy transfer gamma-radiation-induced NFkappaB-dependent telomerase activity in human neuroblastoma cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	70-78
21236599-3	2011	Accordingly, we investigated the effect of curcumin in inhibiting IR-induced NFkappaB-dependent hTERT transcription, TA, and cell survival in neuroblastoma cells.	Curcumin	43-51	nuclear factor kappa B subunit 1	Homo sapiens	77-85
21236599-7	2011	RESULTS: Curcumin profoundly inhibited IR-induced NFkappaB.	Curcumin	9-17	nuclear factor kappa B subunit 1	Homo sapiens	50-58
21236599-13	2011	Consequently, curcumin inhibited hTERT mRNA and TA in NFkappaB overexpressed cells.	Curcumin	14-22	nuclear factor kappa B subunit 1	Homo sapiens	54-62
21236599-15	2011	CONCLUSIONS: These results strongly suggest that curcumin inhibits IR-induced TA in an NFkappaB dependent manner in human neuroblastoma cells.	Curcumin	49-57	nuclear factor kappa B subunit 1	Homo sapiens	87-95
21314329-3	2011	The results showed that curcumin administration increased body weight, decreased serum TNF-alpha levels, increased apoptotic tumor cells, enhanced expression of p53 molecule in tumor tissue, and modulated tumor cell apoptotic pathway.	Curcumin	24-32	tumor necrosis factor	Homo sapiens	87-96
21314329-3	2011	The results showed that curcumin administration increased body weight, decreased serum TNF-alpha levels, increased apoptotic tumor cells, enhanced expression of p53 molecule in tumor tissue, and modulated tumor cell apoptotic pathway.	Curcumin	24-32	tumor protein p53	Homo sapiens	161-164
21314329-4	2011	We conclude that the curcumin treatment improves the general health of patients with colorectal cancer via the mechanism of increased p53 molecule expression in tumor cells and consequently speeds up tumor cell apoptosis.	Curcumin	21-29	tumor protein p53	Homo sapiens	134-137
21187084-11	2011	Furthermore, curcumin reduced the intracellular signaling proteins Ras, B-raf, p-MEK, p-ERK, c-fos, Egr-1, but increased Raf-1 and NAB2 in MDCK cells exposed to forskolin.	Curcumin	13-21	B-Raf proto-oncogene, serine/threonine kinase	Canis lupus familiaris	72-77
21070853-5	2011	The expression of ApoE and ABCA1 induced by synthetic or natural LXR ligands [TO901317, GW3965, and 22-(R)-hydroxycholesterol (22-(R)-HC), respectively] was attenuated by inhibitors of c-Jun N-terminal kinase (JNK) (curcumin and SP600125) and phosphoinositide 3-kinase (PI3K) (LY294002).	Curcumin	216-224	apolipoprotein E	Homo sapiens	18-22
20883815-5	2011	While inhibition of NF-kappaB led to complete inhibition of the synergism of paclitaxel and curcumin, inhibition of Akt brought about only partial reduction of the same, suggesting that, apart from Akt, there are other pathways induced by paclitaxel leading to NF-kappaB activation, which are also down-regulated by curcumin.	Curcumin	92-100	nuclear factor kappa B subunit 1	Homo sapiens	20-29
21173310-7	2011	Serovar Shermani detergent extract also activated nuclear factor-kappaB, and its inhibition by curcumin-attenuated serovar Shermani detergent extract induced increases in fibronectin production.	Curcumin	95-103	fibronectin 1	Homo sapiens	171-182
20883815-7	2011	Up-regulation of Cyclin-D1, Cox-2, XIAP and cIAP1 and phosphorylation of MAPKs, were completely inhibited on inactivation of NF-kappaB assigning a key regulatory role to NF-kappaB in the synergistic effect of paclitaxel and curcumin.	Curcumin	224-232	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
20883815-0	2011	Akt is upstream and MAPKs are downstream of NF-kappaB in paclitaxel-induced survival signaling events, which are down-regulated by curcumin contributing to their synergism.	Curcumin	131-139	AKT serine/threonine kinase 1	Homo sapiens	0-3
20883815-0	2011	Akt is upstream and MAPKs are downstream of NF-kappaB in paclitaxel-induced survival signaling events, which are down-regulated by curcumin contributing to their synergism.	Curcumin	131-139	nuclear factor kappa B subunit 1	Homo sapiens	44-53
20883815-2	2011	Our earlier report has shown that cervical cancer cells can be sensitized by curcumin to paclitaxel-induced apoptosis through down-regulation of NF-kappaB and Akt.	Curcumin	77-85	nuclear factor kappa B subunit 1	Homo sapiens	145-154
20883815-2	2011	Our earlier report has shown that cervical cancer cells can be sensitized by curcumin to paclitaxel-induced apoptosis through down-regulation of NF-kappaB and Akt.	Curcumin	77-85	AKT serine/threonine kinase 1	Homo sapiens	159-162
20883815-7	2011	Up-regulation of Cyclin-D1, Cox-2, XIAP and cIAP1 and phosphorylation of MAPKs, were completely inhibited on inactivation of NF-kappaB assigning a key regulatory role to NF-kappaB in the synergistic effect of paclitaxel and curcumin.	Curcumin	224-232	nuclear factor kappa B subunit 1	Homo sapiens	125-134
20883815-7	2011	Up-regulation of Cyclin-D1, Cox-2, XIAP and cIAP1 and phosphorylation of MAPKs, were completely inhibited on inactivation of NF-kappaB assigning a key regulatory role to NF-kappaB in the synergistic effect of paclitaxel and curcumin.	Curcumin	224-232	nuclear factor kappa B subunit 1	Homo sapiens	170-179
20938987-2	2011	METHODS AND RESULTS: Early passage young human skin fibroblasts treated with low doses of curcumin (below 20 muM) showed a time- and concentration-dependent induction of heme oxygenase-1 (HO-1), followed by compensatory increase in glutathione-S-transferase activity, GSH levels and GSH/GSSG ratio.	Curcumin	90-98	latexin	Homo sapiens	109-112
21304405-4	2011	Curcumin inhibited inducible nitric oxide synthase (iNOS) expression and NO production, and thereby enhanced the proliferation and cytotoxic activity of cocultured lymphocytes and macrophages during IL-2 stimulation which we earlier established as an in vitro model of IL-2-induced NO synthesis.	Curcumin	0-8	nitric oxide synthase 2, inducible	Mus musculus	52-56
21304405-6	2011	In contrast, the curcumin-induced changes in proliferation and apoptosis were not observed in cultures of lymphocytes alone, macrophages alone, and cocultured lymphocytes/iNOS-knock out macrophages, all of which produced little nitrite during IL-2 stimulation.	Curcumin	17-25	nitric oxide synthase 2, inducible	Mus musculus	171-175
21304405-7	2011	In conjunction with IL-2 treatment, oral curcumin administration significantly inhibited IL-2 therapy-induced urinary nitrite/nitrate excretion and iNOS expression of tumor tissues, and further increased the IL-2 therapy-induced prolongation of survival in a murine Meth-A ascites tumor model.	Curcumin	41-49	nitric oxide synthase 2, inducible	Mus musculus	148-152
21282356-5	2011	Curcumin-mediated ER stress via inhibiting the activity of SERCA2 caused increasing expressions of CHOP and its transcription target death receptor 5 (TRAIL-R2), leading to a caspase-3 and caspase-8 cascade-dependent apoptosis in SW872 cells in vitro and in vivo.	Curcumin	0-8	DNA damage inducible transcript 3	Homo sapiens	99-103
21282356-5	2011	Curcumin-mediated ER stress via inhibiting the activity of SERCA2 caused increasing expressions of CHOP and its transcription target death receptor 5 (TRAIL-R2), leading to a caspase-3 and caspase-8 cascade-dependent apoptosis in SW872 cells in vitro and in vivo.	Curcumin	0-8	caspase 3	Homo sapiens	175-184
20938987-6	2011	Pharmacological inhibition of phosphatidylinositol 3-kinase, but not other kinases, significantly prevented curcumin-induced HO-1 levels, which was corroborated by the induction of phospho-Akt levels by curcumin.	Curcumin	108-116	AKT serine/threonine kinase 1	Homo sapiens	189-192
20938987-6	2011	Pharmacological inhibition of phosphatidylinositol 3-kinase, but not other kinases, significantly prevented curcumin-induced HO-1 levels, which was corroborated by the induction of phospho-Akt levels by curcumin.	Curcumin	203-211	AKT serine/threonine kinase 1	Homo sapiens	189-192
20938987-9	2011	CONCLUSION: Curcumin induces cellular stress responses in normal human skin fibroblasts through phosphatidylinositol 3-kinase/Akt pathway and redox signaling, supporting the view that curcumin-induced hormetic stimulation of cellular antioxidant defenses can be a useful approach toward anti-aging intervention.	Curcumin	12-20	AKT serine/threonine kinase 1	Homo sapiens	126-129
20938987-9	2011	CONCLUSION: Curcumin induces cellular stress responses in normal human skin fibroblasts through phosphatidylinositol 3-kinase/Akt pathway and redox signaling, supporting the view that curcumin-induced hormetic stimulation of cellular antioxidant defenses can be a useful approach toward anti-aging intervention.	Curcumin	184-192	AKT serine/threonine kinase 1	Homo sapiens	126-129
21195127-9	2011	Curcumin abrogated the membrane translocation of GLUT2 by interrupting the p38 MAPK signaling pathway.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	75-78
21386967-5	2011	Direct or indirect activation of TP53 pathway with 5-aza-2"-deoxycitidine, Curcumin or Nutlin-3 induced an increase in apoptosis of ALL cells.	Curcumin	75-83	tumor protein p53	Homo sapiens	33-37
21195127-10	2011	In addition, curcumin suppressed glut2 expression by stimulating the activity of peroxisome proliferator-activated receptor-gamma (PPARgamma) and de novo synthesis of glutathione.	Curcumin	13-21	peroxisome proliferator activated receptor gamma	Homo sapiens	81-129
21195127-10	2011	In addition, curcumin suppressed glut2 expression by stimulating the activity of peroxisome proliferator-activated receptor-gamma (PPARgamma) and de novo synthesis of glutathione.	Curcumin	13-21	peroxisome proliferator activated receptor gamma	Homo sapiens	131-140
21167259-0	2011	Curcumin I protects the dopaminergic cell line SH-SY5Y from 6-hydroxydopamine-induced neurotoxicity through attenuation of p53-mediated apoptosis.	Curcumin	0-10	tumor protein p53	Homo sapiens	123-126
21127044-2	2011	In this study, curcumin, a compound known to inhibit GR-mediated transcription, was used to examine the different mechanisms by which GR regulates transcription.	Curcumin	15-23	nuclear receptor subfamily 3 group C member 1	Homo sapiens	53-55
21127044-2	2011	In this study, curcumin, a compound known to inhibit GR-mediated transcription, was used to examine the different mechanisms by which GR regulates transcription.	Curcumin	15-23	nuclear receptor subfamily 3 group C member 1	Homo sapiens	134-136
21127044-3	2011	The mechanisms of transcription regulation of metallothioneine-2A (MT2A) and solute carrier family 19 member 2 (SLC19A2), two GR target genes where the hormone-dependent gene activation is inhibited or unaffected by curcumin treatment, respectively, were analyzed by chromatin immunoprecipitation and RT-PCR experiments.	Curcumin	216-224	nuclear receptor subfamily 3 group C member 1	Homo sapiens	126-128
21167259-9	2011	Taken together, these findings indicate that curcumin I protects dopaminergic neurons from 6-OHDA-induced toxicity via the reduction of ROS production, and subsequent attenuation of p53 phosphorylation and reduction of the Bax/Bcl-2 ratio.	Curcumin	45-55	tumor protein p53	Homo sapiens	182-185
21167259-9	2011	Taken together, these findings indicate that curcumin I protects dopaminergic neurons from 6-OHDA-induced toxicity via the reduction of ROS production, and subsequent attenuation of p53 phosphorylation and reduction of the Bax/Bcl-2 ratio.	Curcumin	45-55	BCL2 associated X, apoptosis regulator	Homo sapiens	223-226
21347286-8	2011	Furthermore, curcumin increased the expression of RNA binding proteins CUGBP2/CELF2 and TIA-1.	Curcumin	13-21	CUGBP, Elav-like family member 2	Mus musculus	71-77
21347286-0	2011	RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells.	Curcumin	42-50	CUGBP, Elav-like family member 2	Mus musculus	20-26
21167259-9	2011	Taken together, these findings indicate that curcumin I protects dopaminergic neurons from 6-OHDA-induced toxicity via the reduction of ROS production, and subsequent attenuation of p53 phosphorylation and reduction of the Bax/Bcl-2 ratio.	Curcumin	45-55	BCL2 apoptosis regulator	Homo sapiens	227-232
21347286-0	2011	RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells.	Curcumin	42-50	CUGBP, Elav-like family member 2	Mus musculus	27-32
21347286-3	2011	Here, we have determined that curcumin modulates the expression of RNA binding protein CUGBP2 to inhibit pancreatic cancer growth.	Curcumin	30-38	CUGBP, Elav-like family member 2	Mus musculus	87-93
21347286-8	2011	Furthermore, curcumin increased the expression of RNA binding proteins CUGBP2/CELF2 and TIA-1.	Curcumin	13-21	CUGBP, Elav-like family member 2	Mus musculus	78-83
21347286-9	2011	CUGBP2 binding to COX-2 and VEGF mRNA was also enhanced, thereby increasing mRNA stability, the half-life changing from 30 min to 8 h. On the other hand, silencer-mediated knockdown of CUGBP2 partially restored the expression of COX-2 and VEGF even with curcumin treatment.	Curcumin	254-262	CUGBP, Elav-like family member 2	Mus musculus	0-6
21347286-9	2011	CUGBP2 binding to COX-2 and VEGF mRNA was also enhanced, thereby increasing mRNA stability, the half-life changing from 30 min to 8 h. On the other hand, silencer-mediated knockdown of CUGBP2 partially restored the expression of COX-2 and VEGF even with curcumin treatment.	Curcumin	254-262	CUGBP, Elav-like family member 2	Mus musculus	185-191
21347286-11	2011	CONCLUSION/SIGNIFICANCE: Curcumin inhibits pancreatic tumor growth through mitotic catastrophe by increasing the expression of RNA binding protein CUGBP2, thereby inhibiting the translation of COX-2 and VEGF mRNA.	Curcumin	25-33	CUGBP, Elav-like family member 2	Mus musculus	147-153
21131044-2	2011	It has been previously shown that curcumin targets Abeta plaques and interferes with their formation, suggesting a potential role for prevention or treatment of AD.	Curcumin	34-42	amyloid beta precursor protein	Homo sapiens	51-56
21131044-3	2011	Herein, a click chemistry method was used to generate nanoliposomes decorated with a curcumin derivative, designed to maintain the planar structure required for interaction with Abeta, as directly confirmed by Surface Plasmon Resonance experiments.	Curcumin	85-93	amyloid beta precursor protein	Homo sapiens	178-183
21427908-2	2011	METHODS: SCC-4 were treated with curcumin of 0, 5, 10, 20, 30, 60, 100 micromol x L(-1) in 24 h. MTT assay, Matrigel invasion assay, flow cytometry and fluorescence microscopy were used to examine the effect of curcumin on the growth and metastasis of SCC-4.	Curcumin	33-41	MAU2 sister chromatid cohesion factor	Homo sapiens	9-14
21147222-9	2011	Studies using itraconazole, a CYP3A4 inhibitor, established its role in curcumin metabolism.	Curcumin	72-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	30-36
21134073-6	2011	Combined treatment of isoflavones and curcumin additively suppressed cellular proliferation and induced phosphorylation of ATM, histone H2AX, Chk2 and p53.	Curcumin	38-46	tumor protein p53	Homo sapiens	151-154
21134073-7	2011	Testosterone augmented the activation of the DNA damage response and PARP cleavage induced by curcumin.	Curcumin	94-102	poly(ADP-ribose) polymerase 1	Homo sapiens	69-73
21427908-4	2011	RESULTS: The results showed that curcumin could concentration-dependently inhibit SCC-4 cell proliferation at the concentration range from 20 to 100 micromol x L(-1).	Curcumin	33-41	MAU2 sister chromatid cohesion factor	Homo sapiens	82-87
21427908-5	2011	Furthermore, Matrigel invasion assay indicated that curcumin can reduce SCC-4 cell invasion under the dosage of 20, 30, 60 micromol x L(-1).	Curcumin	52-60	MAU2 sister chromatid cohesion factor	Homo sapiens	72-77
20629184-6	2011	RESULTS: Curcumin attenuated lipopolysaccharide (LPS)-stimulated expression and secretion of macrophage inflammatory protein (MIP)-2, interleukin (IL)-1beta, keratinocyte chemoattractant (KC), and MIP-1alpha in colonic epithelial cells (CECs) and in macrophages.	Curcumin	9-17	interleukin 1 beta	Homo sapiens	134-156
20629184-7	2011	Curcumin significantly inhibited PMN chemotaxis against MIP-2, KC, or against conditioned media from LPS-treated macrophages or CEC, a well as the IL-8-mediated chemotaxis of human neutrophils.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
20629184-9	2011	Curcumin-mediated inhibition of PMN motility could be attributed to a downregulation of PI3K activity, AKT phosphorylation, and F-actin polymerization at the leading edge.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	103-106
21427908-6	2011	Flow cytometry also showed that curcumin can influence the distribution of cell cycle of SCC-4 cell with the dosage of 20, 30, 60 micromol x L(-1).	Curcumin	32-40	MAU2 sister chromatid cohesion factor	Homo sapiens	89-94
20950131-9	2011	Protein concentration of IL-1beta, IL-6 (section 3), and CCL2 was increased (P &lt; 0.05) and curcumin reduced this response for IL-1beta (section 2) and CCL2 (P &lt; 0.05).	Curcumin	94-102	interleukin 1 beta	Mus musculus	129-137
20971552-6	2011	We show that Wnt inhibitors curcumin and quercetin target downstream beta-catenin activity and effectively repress HBx-mediated regulation of c-MYC and E-cadherin.	Curcumin	28-36	cadherin 1	Homo sapiens	152-162
21461234-6	2011	We also observed that NAC abolished curcumin-induced activation of extracelluar signal-regulated kinases (ERK) 1/2 and p38 mitogen-activated protein kinases (MAPK), but not Jun N-terminal kinase (JNK).	Curcumin	36-44	mitogen-activated protein kinase 3	Homo sapiens	67-114
21461234-6	2011	We also observed that NAC abolished curcumin-induced activation of extracelluar signal-regulated kinases (ERK) 1/2 and p38 mitogen-activated protein kinases (MAPK), but not Jun N-terminal kinase (JNK).	Curcumin	36-44	mitogen-activated protein kinase 1	Homo sapiens	119-122
21461234-6	2011	We also observed that NAC abolished curcumin-induced activation of extracelluar signal-regulated kinases (ERK) 1/2 and p38 mitogen-activated protein kinases (MAPK), but not Jun N-terminal kinase (JNK).	Curcumin	36-44	mitogen-activated protein kinase 3	Homo sapiens	158-162
20574713-5	2011	Increased superoxide dismutase and catalase activities in kidney cortex of T(4)-treated rats were ameliorated in response to vitamin E or/and curcumin treatment.	Curcumin	142-150	catalase	Rattus norvegicus	35-43
20574713-6	2011	The elevated translated product of Cu/Zn-SOD, Mn-SOD and catalase in T(4)-treated rats were differentially reduced by the administration of vitamin E and curcumin independently or in combination.	Curcumin	154-162	superoxide dismutase 1	Rattus norvegicus	35-44
20574713-6	2011	The elevated translated product of Cu/Zn-SOD, Mn-SOD and catalase in T(4)-treated rats were differentially reduced by the administration of vitamin E and curcumin independently or in combination.	Curcumin	154-162	catalase	Rattus norvegicus	57-65
20574713-7	2011	Cu/Zn-SOD expression was ameliorated by both vitamin E and curcumin independently or in combination, whereas Mn-SOD expression was ameliorated by the supplementation of vitamin E or curcumin independently.	Curcumin	59-67	superoxide dismutase 1	Rattus norvegicus	0-9
21094287-2	2011	Previous works showed that curcumin decreased lipopolysaccharide (LPS)-induced iNOS up-regulation at transcription level.	Curcumin	27-35	nitric oxide synthase 2, inducible	Mus musculus	79-83
21094287-3	2011	However, whether curcumin could regulate iNOS at the post-translational level is still unclear.	Curcumin	17-25	nitric oxide synthase 2, inducible	Mus musculus	41-45
21094287-4	2011	In the present study, we demonstrated that curcumin promoted the degradation of iNOS which is expressed under LPS stimulation in murine macrophage-like RAW 264.7 cells.	Curcumin	43-51	nitric oxide synthase 2, inducible	Mus musculus	80-84
21094287-6	2011	Furthermore, curcumin decreased iNOS tyrosine phosphorylation through inhibiting ERK 1/2 activation and subsequently suppressed iNOS enzyme activity.	Curcumin	13-21	nitric oxide synthase 2, inducible	Mus musculus	32-36
21094287-6	2011	Furthermore, curcumin decreased iNOS tyrosine phosphorylation through inhibiting ERK 1/2 activation and subsequently suppressed iNOS enzyme activity.	Curcumin	13-21	nitric oxide synthase 2, inducible	Mus musculus	128-132
21094287-7	2011	In conclusion, our research displays a new finding that curcumin can promote the ubiqitination and degradation of iNOS after LPS stimulation.	Curcumin	56-64	nitric oxide synthase 2, inducible	Mus musculus	114-118
20848615-7	2011	Cytokines as tumor necrosis factor-alpha and IFN-gamma were significantly diminished in DSS-animals fed with curcumin.	Curcumin	109-117	tumor necrosis factor	Mus musculus	13-40
20848615-7	2011	Cytokines as tumor necrosis factor-alpha and IFN-gamma were significantly diminished in DSS-animals fed with curcumin.	Curcumin	109-117	interferon gamma	Mus musculus	45-54
21044622-9	2011	Moreover, pretreatment with SP600125 (JNK inhibitor) or curcumin (AP-1 inhibitor) markedly attenuated the berberine-induced PON1 promoter activity and protein expression.	Curcumin	56-64	paraoxonase 1	Homo sapiens	124-128
21183341-4	2011	2-Hydroxycurcuminoid (HCC-7) strongly inhibited the growth of SW620 colon tumor cells with a GI(50) value of 7muM, while the parent compounds, HCA and curcumin, displayed GI(50) values of 12 and 30muM, respectively.	Curcumin	9-17	latexin	Homo sapiens	110-113
20637579-11	2011	The change of inflammation cytokine, including TNF-alpha and IL-6, may play an important role in the mechanisms of action of curcumin, but the detail mechanism remains unknown.	Curcumin	125-133	tumor necrosis factor	Mus musculus	47-56
20637579-11	2011	The change of inflammation cytokine, including TNF-alpha and IL-6, may play an important role in the mechanisms of action of curcumin, but the detail mechanism remains unknown.	Curcumin	125-133	interleukin 6	Mus musculus	61-65
20950605-0	2011	Downregulation of B lymphocyte stimulator expression by curcumin in B lymphocyte via suppressing nuclear translocation of NF-kappaB.	Curcumin	56-64	nuclear factor kappa B subunit 1	Homo sapiens	122-131
20950605-4	2011	In this study, we report that curcumin inhibits the expression of BLyS and that a DNA-binding site for the transcriptional factor NF-kappaB in the BLyS promoter region is required for this regulation.	Curcumin	30-38	nuclear factor kappa B subunit 1	Homo sapiens	130-139
20950605-5	2011	Moreover, we find that curcumin reduces the DNA-binding activity of NF-kappaB to the BLyS promoter region and suppresses nuclear translocation of p65, suggesting that curcumin may suppress BLyS expression via negatively interfering with NF-kappaB signaling.	Curcumin	23-31	nuclear factor kappa B subunit 1	Homo sapiens	68-77
20950605-5	2011	Moreover, we find that curcumin reduces the DNA-binding activity of NF-kappaB to the BLyS promoter region and suppresses nuclear translocation of p65, suggesting that curcumin may suppress BLyS expression via negatively interfering with NF-kappaB signaling.	Curcumin	23-31	nuclear factor kappa B subunit 1	Homo sapiens	237-246
20950605-5	2011	Moreover, we find that curcumin reduces the DNA-binding activity of NF-kappaB to the BLyS promoter region and suppresses nuclear translocation of p65, suggesting that curcumin may suppress BLyS expression via negatively interfering with NF-kappaB signaling.	Curcumin	167-175	nuclear factor kappa B subunit 1	Homo sapiens	68-77
20950605-5	2011	Moreover, we find that curcumin reduces the DNA-binding activity of NF-kappaB to the BLyS promoter region and suppresses nuclear translocation of p65, suggesting that curcumin may suppress BLyS expression via negatively interfering with NF-kappaB signaling.	Curcumin	167-175	nuclear factor kappa B subunit 1	Homo sapiens	237-246
21130735-4	2011	We have recently demonstrated in vitro that polyphenolic phytochemicals, curcumin and masoprocol, can rescue S-nitroso-PDI formation by scavenging NOx.	Curcumin	73-81	protein disulfide isomerase family A member 2	Homo sapiens	119-122
21720000-3	2011	It has been reported that curcumin has the potential to protect against cardiac inflammation through suppression of GATA-4 and nuclear factor-kappaB (NF-kappaB); however, no study to date has addressed the effect of curcumin on experimental autoimmune myocarditis (EAM) in rats.	Curcumin	26-34	GATA binding protein 4	Rattus norvegicus	116-148
20851099-0	2011	Apolipoprotein E LDL receptor-binding domain-containing high-density lipoprotein: a nanovehicle to transport curcumin, an antioxidant and anti-amyloid bioflavonoid.	Curcumin	109-117	apolipoprotein E	Homo sapiens	0-16
20851099-3	2011	The objective of this study was to employ reconstituted HDL containing human apoE3 N-terminal (NT) domain, as a vehicle to transport curcumin.	Curcumin	133-141	apolipoprotein E	Homo sapiens	77-82
20851099-11	2011	Functional assays indicated that the LDLr-binding ability of curcumin-containing HDL with apoE3-NT is similar to that of HDL without curcumin.	Curcumin	61-69	apolipoprotein E	Homo sapiens	90-95
20851099-12	2011	Taken together, we report that apoE-containing HDL has a tremendous potential as a "nanovehicle" with a homing device to transport curcumin to target sites.	Curcumin	131-139	apolipoprotein E	Homo sapiens	31-35
22292626-0	2011	Curcumin induces apoptosis involving bax/bcl-2 in human hepatoma SMMC-7721 cells.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	37-40
22292626-0	2011	Curcumin induces apoptosis involving bax/bcl-2 in human hepatoma SMMC-7721 cells.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	41-46
22292626-4	2011	Annexin-V/PI double staining detected by flow cytometry and expression of the relative apoptotic proteins (Bax, Bcl-2 and caspase-3) revealed a strong apoptosis-inducing competent of curcumin in SMMC-7721 cells.	Curcumin	183-191	BCL2 associated X, apoptosis regulator	Homo sapiens	107-110
22292626-4	2011	Annexin-V/PI double staining detected by flow cytometry and expression of the relative apoptotic proteins (Bax, Bcl-2 and caspase-3) revealed a strong apoptosis-inducing competent of curcumin in SMMC-7721 cells.	Curcumin	183-191	BCL2 apoptosis regulator	Homo sapiens	112-117
22292626-4	2011	Annexin-V/PI double staining detected by flow cytometry and expression of the relative apoptotic proteins (Bax, Bcl-2 and caspase-3) revealed a strong apoptosis-inducing competent of curcumin in SMMC-7721 cells.	Curcumin	183-191	caspase 3	Homo sapiens	122-131
22292626-5	2011	Curcumin increased the expression of bax protein while decreasing that of bc1-2 protein significantly.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	37-40
22292626-5	2011	Curcumin increased the expression of bax protein while decreasing that of bc1-2 protein significantly.	Curcumin	0-8	charged multivesicular body protein 2A	Homo sapiens	74-79
22292626-6	2011	The results suggest that curcumin induction of apoptosis involves modulation of bax/bcl-2 in SMMC-7721 cells and provide a molecular basis for the development of naturally compounds as novel anticancer agents for human hepatomas.	Curcumin	25-33	BCL2 associated X, apoptosis regulator	Homo sapiens	80-83
22292626-6	2011	The results suggest that curcumin induction of apoptosis involves modulation of bax/bcl-2 in SMMC-7721 cells and provide a molecular basis for the development of naturally compounds as novel anticancer agents for human hepatomas.	Curcumin	25-33	BCL2 apoptosis regulator	Homo sapiens	84-89
21415532-12	2011	Furthermore, curcumin was found to inhibit the DNA-binding activity of NF-kappaB.	Curcumin	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-80
21415532-13	2011	The present study demonstrated that curcumin has a protective effect on LPS-induced experimental renal inflammation, and this effect might be attributed to its inhibitory effects on MCP-1 mRNA expression and DNA-binding activity of NF-kappaB.	Curcumin	36-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	232-241
21804205-0	2011	Activation of nuclear factor erythroid 2-related factor 2 cytoprotective signaling by curcumin protect primary spinal cord astrocytes against oxidative toxicity.	Curcumin	86-94	NFE2 like bZIP transcription factor 2	Homo sapiens	14-57
21804205-7	2011	We report herein that curcumin significantly activates Nrf2 target genes in primary spinal cord astrocytes, decreases the level of intracellular reactive oxygen species (ROS), and attenuates oxidative damage and mitochondrial dysfunction.	Curcumin	22-30	NFE2 like bZIP transcription factor 2	Homo sapiens	55-59
21720000-8	2011	Furthermore, curcumin reduced the heart weight-to-body weight ratio, area of inflammatory lesions and the myocardial protein level of NF-kappaB, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and GATA-4.	Curcumin	13-21	interleukin 1 beta	Rattus norvegicus	145-167
21720000-8	2011	Furthermore, curcumin reduced the heart weight-to-body weight ratio, area of inflammatory lesions and the myocardial protein level of NF-kappaB, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and GATA-4.	Curcumin	13-21	tumor necrosis factor	Rattus norvegicus	169-202
21720000-8	2011	Furthermore, curcumin reduced the heart weight-to-body weight ratio, area of inflammatory lesions and the myocardial protein level of NF-kappaB, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and GATA-4.	Curcumin	13-21	GATA binding protein 4	Rattus norvegicus	207-213
21720000-9	2011	Our results indicate that curcumin has the potential to protect against cardiac inflammation through suppression of IL-1beta, TNF-alpha, GATA-4 and NF-kappaB expresses, and may provide a novel therapeutic strategy for autoimmune myocarditis.	Curcumin	26-34	interleukin 1 beta	Rattus norvegicus	116-124
21720000-9	2011	Our results indicate that curcumin has the potential to protect against cardiac inflammation through suppression of IL-1beta, TNF-alpha, GATA-4 and NF-kappaB expresses, and may provide a novel therapeutic strategy for autoimmune myocarditis.	Curcumin	26-34	tumor necrosis factor	Rattus norvegicus	126-135
21720000-9	2011	Our results indicate that curcumin has the potential to protect against cardiac inflammation through suppression of IL-1beta, TNF-alpha, GATA-4 and NF-kappaB expresses, and may provide a novel therapeutic strategy for autoimmune myocarditis.	Curcumin	26-34	GATA binding protein 4	Rattus norvegicus	137-143
21109950-9	2011	Thus, in this study, we investigated the inhibitory effects of two STAT3 inhibitors, LLL12 and FLLL32, on the STAT3 signaling pathway in human rhabodomyosarcoma cells; we also demonstrated their higher potency in inhibiting proliferation on human rhabodomyosarcoma cells as compared to other five JAK2/STAT3 inhibitors and curcumin.	Curcumin	323-331	signal transducer and activator of transcription 3	Homo sapiens	67-72
22179005-0	2011	Curcumin blocks Kv11.1 (erg) potassium current and slows proliferation in the infant acute monocytic leukemia cell line THP-1.	Curcumin	0-8	GLI family zinc finger 2	Homo sapiens	120-125
22179005-6	2011	Curcumin was rapidly internalized by THP-1 cells and possibly exerts potential growth inhibitory activity by interacting with intracellular epitopes of the ion channel.	Curcumin	0-8	GLI family zinc finger 2	Homo sapiens	37-42
21078213-0	2011	Curcumin induces paraoxonase 1 in cultured hepatocytes in vitro but not in mouse liver in vivo.	Curcumin	0-8	paraoxonase 1	Mus musculus	17-30
21078213-2	2011	Using a luciferase reporter gene assay, we tested curcumin for its ability to induce PON1 in Huh7 hepatocytes in culture.	Curcumin	50-58	paraoxonase 1	Mus musculus	85-89
21078213-3	2011	Curcumin ( &gt;= 10 mumol/l) dose-dependently induced PON1 transactivation in Huh7 cells.	Curcumin	0-8	paraoxonase 1	Homo sapiens	54-58
21078213-6	2011	In conclusion, curcumin may be a potent PON1 inducer in cultured cells in vitro, but not in the liver of curcumin-fed mice because of its low concentrations in vivo.	Curcumin	15-23	paraoxonase 1	Mus musculus	40-44
22135900-9	2011	The effect of ethyl acetate extract was comparable to the effect of curcumin, a known NF-kappaB pathway inhibitor, and seemed to be the most active inhibitor of H2O2-dependent IkappaBalpha phosphorylation.	Curcumin	68-76	nuclear factor kappa B subunit 1	Homo sapiens	86-95
21335654-10	2011	These results strongly suggested that curcumin binds to Abeta oligomers and to Abeta fibrils.	Curcumin	38-46	histocompatibility 2, class II antigen A, beta 1	Mus musculus	56-61
21335654-11	2011	The association of curcumin with Abeta oligomers may contribute to the therapeutic effect on AD.	Curcumin	19-27	histocompatibility 2, class II antigen A, beta 1	Mus musculus	33-38
21335654-12	2011	Based on these findings, curcumin could provide the basis of a novel concept in AD therapies targeting Abeta oligomers.	Curcumin	25-33	histocompatibility 2, class II antigen A, beta 1	Mus musculus	103-108
32272532-4	2011	Curcumin (10 muM) inhibited store-operated Ca2+ entry (SOCE).	Curcumin	0-8	latexin	Homo sapiens	13-16
20959361-0	2011	Curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-kappaB pathways through a crossed phosphatidylinositol 3-kinase/Akt/IkappaB kinase complex signaling axis in adenoid cystic carcinoma.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	143-146
20959361-6	2011	The ability of ACC cells to migrate/invade and induce angiogenesis was also significantly attenuated by curcumin, accompanied by the down-regulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 and -9.	Curcumin	104-112	vascular endothelial growth factor A	Homo sapiens	188-192
20959361-7	2011	Moreover, our data also demonstrated that the inhibitory effects of curcumin on ACC cells were due to its dual inhibition of both mammalian target of rapamycin (mTOR) and nuclear factor-kappaB (NF-kappaB) pathways through a crossed phosphatidylinositol 3-kinase/Akt/IkappaBalpha kinase signaling axis.	Curcumin	68-76	mechanistic target of rapamycin kinase	Homo sapiens	161-165
20959361-7	2011	Moreover, our data also demonstrated that the inhibitory effects of curcumin on ACC cells were due to its dual inhibition of both mammalian target of rapamycin (mTOR) and nuclear factor-kappaB (NF-kappaB) pathways through a crossed phosphatidylinositol 3-kinase/Akt/IkappaBalpha kinase signaling axis.	Curcumin	68-76	AKT serine/threonine kinase 1	Homo sapiens	262-265
20959361-7	2011	Moreover, our data also demonstrated that the inhibitory effects of curcumin on ACC cells were due to its dual inhibition of both mammalian target of rapamycin (mTOR) and nuclear factor-kappaB (NF-kappaB) pathways through a crossed phosphatidylinositol 3-kinase/Akt/IkappaBalpha kinase signaling axis.	Curcumin	68-76	NFKB inhibitor alpha	Homo sapiens	266-278
20959361-10	2011	Taken together, our findings suggest that further clinical investigation is warranted to apply curcumin as a novel chemotherapeutic regimen for ACC because of its dual suppression of both mTOR and NF-kappaB pathways.	Curcumin	95-103	mechanistic target of rapamycin kinase	Homo sapiens	188-192
21343666-5	2011	Consistently, dose-dependent inhibition of I(CRAC) by curcumin was confirmed in Jurkat-T (IC(50), 5.9 microM) and the HEK293 cells overexpressing Orai1 and STIM1 (IC(50), 0.6 microM).	Curcumin	54-62	stromal interaction molecule 1	Homo sapiens	156-161
20972609-9	2011	We found that among the bioconjugates, the glutamoyl diester of curcumin showed improved protection against PN-dependent CI inhibition and protein nitration compared to other conjugates.	Curcumin	64-72	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	108-110
32272532-5	2011	Consistently, dose-dependent inhibition of ICRAC by curcumin was confirmed in Jurkat-T (IC50, 5.9 muM) and the HEK293 cells overexpressing Orai1 and STIM1 (IC50, 0.6 muM).	Curcumin	52-60	latexin	Homo sapiens	98-101
32272532-5	2011	Consistently, dose-dependent inhibition of ICRAC by curcumin was confirmed in Jurkat-T (IC50, 5.9 muM) and the HEK293 cells overexpressing Orai1 and STIM1 (IC50, 0.6 muM).	Curcumin	52-60	stromal interaction molecule 1	Homo sapiens	149-154
32272532-5	2011	Consistently, dose-dependent inhibition of ICRAC by curcumin was confirmed in Jurkat-T (IC50, 5.9 muM) and the HEK293 cells overexpressing Orai1 and STIM1 (IC50, 0.6 muM).	Curcumin	52-60	latexin	Homo sapiens	166-169
32272532-6	2011	Also, curcumin inhibited both IKv (IC50, 11.9 muM) and ISK4 (IC50, 4.2 muM).	Curcumin	6-14	latexin	Homo sapiens	46-49
32272532-6	2011	Also, curcumin inhibited both IKv (IC50, 11.9 muM) and ISK4 (IC50, 4.2 muM).	Curcumin	6-14	latexin	Homo sapiens	71-74
20869986-11	2011	Meanwhile, pretreatment with curcumin abrogated cytochrome c release, blocked activation of Caspase-3, and altered the expression of Bcl-2 family triggered by ONOO(-).	Curcumin	29-37	BCL2, apoptosis regulator	Rattus norvegicus	133-138
21857083-7	2011	Furthermore, curcumin enhanced expression of H2O2-induced pro-apoptotic protein Bax expression and inhibited expression of anti-apoptotic proteins Bcl-2 and Bcl-xL.	Curcumin	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	80-83
21857083-7	2011	Furthermore, curcumin enhanced expression of H2O2-induced pro-apoptotic protein Bax expression and inhibited expression of anti-apoptotic proteins Bcl-2 and Bcl-xL.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	147-152
21857083-7	2011	Furthermore, curcumin enhanced expression of H2O2-induced pro-apoptotic protein Bax expression and inhibited expression of anti-apoptotic proteins Bcl-2 and Bcl-xL.	Curcumin	13-21	BCL2 like 1	Homo sapiens	157-163
21858029-8	2011	Pre-treatment using 0.01%-0.25% curcumin in diets significantly inhibited I/R-induced cell loss in GCL.	Curcumin	32-40	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	99-102
20550967-5	2011	In APP(SWE)/PS1( E9) transgenic mice (AD-Tg; n=18) but not in non-Tg wt mice (n=10), retinal Abeta plaques were detected following systemic administration of curcumin, a safe plaque-labeling fluorochrome.	Curcumin	158-166	amyloid beta precursor protein	Homo sapiens	93-98
20550967-8	2011	In live AD-Tg mice (n=24), systemic administration of curcumin allowed noninvasive optical imaging of retinal Abeta plaques in vivo with high resolution and specificity; plaques were undetectable in non-Tg wt mice (n=11).	Curcumin	54-62	amyloid beta precursor protein	Homo sapiens	110-115
21858029-9	2011	0.05% curcumin pre-treatment inhibited I/R-induced degeneration of retinal capillaries, TUNEL-positive apoptotic cell death in the GCL, brn3a stained cell loss, the I/R-induced up-regulation of MCP-1, IKKalpha, p-IkappaBalpha and p-STAT3 (Tyr), and down-regulation of beta-tubulin III.	Curcumin	6-14	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	131-134
21858029-9	2011	0.05% curcumin pre-treatment inhibited I/R-induced degeneration of retinal capillaries, TUNEL-positive apoptotic cell death in the GCL, brn3a stained cell loss, the I/R-induced up-regulation of MCP-1, IKKalpha, p-IkappaBalpha and p-STAT3 (Tyr), and down-regulation of beta-tubulin III.	Curcumin	6-14	mast cell protease 1-like 1	Rattus norvegicus	194-199
21858029-13	2011	The beneficial effects of curcumin on neurovascular degeneration may occur through its inhibitory effects on injury-induced activation of NF-kappaB and STAT3, and on over-expression of MCP-1.	Curcumin	26-34	mast cell protease 1-like 1	Rattus norvegicus	185-190
21887247-9	2011	This point out that nano-curcumin affects the HIV-1 induced inflammatory responses through pathways downstream or independent of TNF alpha.	Curcumin	25-33	tumor necrosis factor	Homo sapiens	129-138
21858220-0	2011	Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapy.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	17-21
21858220-0	2011	Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapy.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	71-74
21858220-4	2011	METHODS/PRINCIPAL FINDINGS: After screening 598 herbal and natural compounds, we found curcumin could inhibit cell proliferation in different gefitinib-resistant NSCLC cell lines; concentration-dependently down-regulate EGFR phosphorylation through promoting EGFR degradation in NSCLC cell lines with wild-type EGFR or T790M EGFR.	Curcumin	87-95	epidermal growth factor receptor	Homo sapiens	220-224
21858220-4	2011	METHODS/PRINCIPAL FINDINGS: After screening 598 herbal and natural compounds, we found curcumin could inhibit cell proliferation in different gefitinib-resistant NSCLC cell lines; concentration-dependently down-regulate EGFR phosphorylation through promoting EGFR degradation in NSCLC cell lines with wild-type EGFR or T790M EGFR.	Curcumin	87-95	epidermal growth factor receptor	Homo sapiens	259-263
21858220-4	2011	METHODS/PRINCIPAL FINDINGS: After screening 598 herbal and natural compounds, we found curcumin could inhibit cell proliferation in different gefitinib-resistant NSCLC cell lines; concentration-dependently down-regulate EGFR phosphorylation through promoting EGFR degradation in NSCLC cell lines with wild-type EGFR or T790M EGFR.	Curcumin	87-95	epidermal growth factor receptor	Homo sapiens	259-263
21858220-4	2011	METHODS/PRINCIPAL FINDINGS: After screening 598 herbal and natural compounds, we found curcumin could inhibit cell proliferation in different gefitinib-resistant NSCLC cell lines; concentration-dependently down-regulate EGFR phosphorylation through promoting EGFR degradation in NSCLC cell lines with wild-type EGFR or T790M EGFR.	Curcumin	87-95	epidermal growth factor receptor	Homo sapiens	259-263
21858220-7	2011	We showed that curcumin attenuated the gefitinib-induced cell proliferation inhibition and apoptosis through altering p38 mitogen-activated protein kinase (MAPK) activation in intestinal epithelia cell.	Curcumin	15-23	mitogen-activated protein kinase 14	Homo sapiens	118-154
21858220-9	2011	In addition, curcumin attenuates gefitinib-induced gastrointestinal adverse effects via altering p38 activation.	Curcumin	13-21	mitogen-activated protein kinase 14	Homo sapiens	97-100
21034749-11	2010	SIGNIFICANCE: p300 interacts with cardiac-specific genes, GATA4, Nkx2.5 and Mef2c, and inhibition of p300-HAT by curcumin down-regulates their expression through the inhibition of histone H3 acetylation in the promoter regions.	Curcumin	113-121	GATA binding protein 4	Mus musculus	58-63
27186104-2	2011	In-silico analysis shows that amphotericin B and curcumin have separate binding regions on human serum albumin and bovine serum albumin.	Curcumin	49-57	albumin	Homo sapiens	97-110
27186104-2	2011	In-silico analysis shows that amphotericin B and curcumin have separate binding regions on human serum albumin and bovine serum albumin.	Curcumin	49-57	albumin	Homo sapiens	122-135
21034749-11	2010	SIGNIFICANCE: p300 interacts with cardiac-specific genes, GATA4, Nkx2.5 and Mef2c, and inhibition of p300-HAT by curcumin down-regulates their expression through the inhibition of histone H3 acetylation in the promoter regions.	Curcumin	113-121	myocyte enhancer factor 2C	Mus musculus	76-81
20937840-7	2010	The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.	Curcumin	25-33	nuclear factor kappa B subunit 1	Homo sapiens	4-13
20937840-7	2010	The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.	Curcumin	25-33	interleukin 1 receptor associated kinase 2	Homo sapiens	90-96
20717830-9	2010	The elevation of ECM and TGF-beta1/p-SMAD-2 level was substantially blocked by the cellular uptake of curcumin in a dose-dependent manner in all the seven primary KFs.	Curcumin	102-110	transforming growth factor beta 1	Homo sapiens	25-34
20664557-5	2010	The differences between lesional and nonlesional skin were further investigated by studying the induced expression of Nrf2-dependent transcripts in skin punch biopsies using curcumin and santalol.	Curcumin	174-182	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
21204771-5	2010	HL-60 cells underwent apoptosis on treatment with curcumin, as indicated by increased annexin V-binding capacity and caspase-3 activation with flow cytometric analysis.	Curcumin	50-58	caspase 3	Homo sapiens	117-126
21204771-6	2010	Concentrations of 15, 20, and 40 muM curcumin significantly reduced cell proliferations.	Curcumin	37-45	latexin	Homo sapiens	33-36
21204771-7	2010	When HL-60 cells were treated with 10, 15, 20, and 40 muM concentration of curcumin, apoptotic rates were determined as 1.2, 81.1, 84.5, and 88.6%, respectively.	Curcumin	75-83	latexin	Homo sapiens	54-57
21204771-8	2010	On the incubations with the concentrations of curcumin, caspase-3 expressions (+) were found to be elevated by 8.5, 18.6, 91.2, and 92.4%, respectively.	Curcumin	46-54	caspase 3	Homo sapiens	56-65
21138870-0	2010	Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway.	Curcumin	8-16	signal transducer and activator of transcription 3	Mus musculus	97-102
21138870-6	2010	RESULTS: In vitro, curcumin inhibited JAK1,2/STAT3 tyrosine-phosphorylation in a dose-dependent fashion in murine glioma cell lines.	Curcumin	19-27	signal transducer and activator of transcription 3	Mus musculus	45-50
21138870-7	2010	Real-time RT-PCR revealed that curcumin downregulated transcription of the STAT3 target genes c-Myc, MMP-9, Snail, and Twist, and of the proliferation marker Ki67.	Curcumin	31-39	signal transducer and activator of transcription 3	Mus musculus	75-80
19730790-3	2010	Effective inhibitions of the Wnt/beta-catenin pathway by curcumin and PKF118-310 in osteosarcoma cells were shown by the suppression of both intrinsic and activated beta-catenin/Tcf transcriptional activities using luciferase reporter assays.	Curcumin	57-65	hepatocyte nuclear factor 4 alpha	Homo sapiens	178-181
20851953-3	2010	AKT/MTOR pathway biomarkers are intrinsic to the carcinogenic process as well as the mechanism of intervention with curcumin.	Curcumin	116-124	AKT serine/threonine kinase 1	Homo sapiens	0-3
20851953-3	2010	AKT/MTOR pathway biomarkers are intrinsic to the carcinogenic process as well as the mechanism of intervention with curcumin.	Curcumin	116-124	mechanistic target of rapamycin kinase	Homo sapiens	4-8
20851953-6	2010	The antiproliferative effects of curcumin were associated with inhibition of the AKT/MTOR pathway in presence and absence of nicotine, which also induced this pathway.	Curcumin	33-41	AKT serine/threonine kinase 1	Homo sapiens	81-84
20851953-6	2010	The antiproliferative effects of curcumin were associated with inhibition of the AKT/MTOR pathway in presence and absence of nicotine, which also induced this pathway.	Curcumin	33-41	mechanistic target of rapamycin kinase	Homo sapiens	85-89
20851953-7	2010	Curcumin was highly effective at suppressing growth of SCC40 xenografts and its activity is associated with modulation of MTOR"s downstream target pS6.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	122-126
20851953-10	2010	This is the first study to demonstrate that curcumin inhibits the adverse effects of nicotine by blocking nicotine-induced activation of the AKT/MTOR pathway in HNSCC, which retards cell migration.	Curcumin	44-52	AKT serine/threonine kinase 1	Homo sapiens	141-144
20851953-10	2010	This is the first study to demonstrate that curcumin inhibits the adverse effects of nicotine by blocking nicotine-induced activation of the AKT/MTOR pathway in HNSCC, which retards cell migration.	Curcumin	44-52	mechanistic target of rapamycin kinase	Homo sapiens	145-149
20851953-11	2010	These studies indicate that inhibiting the AKT/MTOR pathway with curcumin may be useful as an oral chemopreventive agent.	Curcumin	65-73	AKT serine/threonine kinase 1	Homo sapiens	43-46
20851953-11	2010	These studies indicate that inhibiting the AKT/MTOR pathway with curcumin may be useful as an oral chemopreventive agent.	Curcumin	65-73	mechanistic target of rapamycin kinase	Homo sapiens	47-51
20934787-4	2010	In this study, 33 novel mono-carbonyl analogues of curcumin were synthesized and their inhibition against TNF-alpha and IL-6 release was evaluated in LPS-stimulated RAW 264.7 macrophages.	Curcumin	51-59	tumor necrosis factor	Homo sapiens	106-115
20934787-4	2010	In this study, 33 novel mono-carbonyl analogues of curcumin were synthesized and their inhibition against TNF-alpha and IL-6 release was evaluated in LPS-stimulated RAW 264.7 macrophages.	Curcumin	51-59	interleukin 6	Homo sapiens	120-124
21311680-0	2010	Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species.	Curcumin	0-8	E2F transcription factor 4 S homeolog	Xenopus laevis	35-39
21221209-0	2010	Dimethoxycurcumin, a structural analogue of curcumin, induces apoptosis in human renal carcinoma caki cells through the production of reactive oxygen species, the release of cytochrome C, and the activation of caspase-3.	Curcumin	9-17	cytochrome c, somatic	Homo sapiens	174-186
21221209-0	2010	Dimethoxycurcumin, a structural analogue of curcumin, induces apoptosis in human renal carcinoma caki cells through the production of reactive oxygen species, the release of cytochrome C, and the activation of caspase-3.	Curcumin	9-17	caspase 3	Homo sapiens	210-219
21311680-5	2010	Anti-proliferative effect of curcumin was also suppressed by NAC which is consistent to previous reports showing curcumin-superoxide production and induction of poly (ADP-ribose) polymerase (PARP) cleavage as well as apoptosis.	Curcumin	29-37	poly(ADP-ribose) polymerase 1	Homo sapiens	161-189
19908170-0	2010	Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	35-40
21311680-5	2010	Anti-proliferative effect of curcumin was also suppressed by NAC which is consistent to previous reports showing curcumin-superoxide production and induction of poly (ADP-ribose) polymerase (PARP) cleavage as well as apoptosis.	Curcumin	29-37	poly(ADP-ribose) polymerase 1	Homo sapiens	191-195
19908170-0	2010	Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells.	Curcumin	0-8	glycerophosphodiester phosphodiesterase 1	Homo sapiens	69-75
19908170-3	2010	In our study, we confirmed that the expression of miR-15a and miR-16 was upregulated and that of Bcl-2 was downregulated in curcumin-treated MCF-7 cells.	Curcumin	124-132	glycerophosphodiester phosphodiesterase 1	Homo sapiens	62-68
21311680-6	2010	Expression of several genes, cyclin A, p21, and p27, which has been shown to be regulated in E2F4-dependent manner and involved in the cell cycle progression was also affected by curcumin.	Curcumin	179-187	cyclin A2	Homo sapiens	29-37
19908170-3	2010	In our study, we confirmed that the expression of miR-15a and miR-16 was upregulated and that of Bcl-2 was downregulated in curcumin-treated MCF-7 cells.	Curcumin	124-132	BCL2 apoptosis regulator	Homo sapiens	97-102
19908170-5	2010	Thus, we concluded that curcumin can reduce the expression of Bcl-2 by upregulating the expression of miR-15a and miR-16 in MCF-7 cells.	Curcumin	24-32	BCL2 apoptosis regulator	Homo sapiens	62-67
21311680-7	2010	Moreover, decreased (cyclin A) and increased (p21 and p27) expression of these E2F4 downstream genes by curcumin was restored by pretreatment of cells with NAC and E2F4 overexpression which is induced by doxycycline.	Curcumin	104-112	cyclin A2	Homo sapiens	21-29
19908170-5	2010	Thus, we concluded that curcumin can reduce the expression of Bcl-2 by upregulating the expression of miR-15a and miR-16 in MCF-7 cells.	Curcumin	24-32	glycerophosphodiester phosphodiesterase 1	Homo sapiens	114-120
20934924-1	2010	Curcumin and tetrahydrocurcumin (THC) have been found as potent DNMT1 inhibitors, but they suffer from low oral bioavailability and rapid metabolism in vivo.	Curcumin	0-8	DNA methyltransferase (cytosine-5) 1	Mus musculus	64-69
20680030-0	2010	Curcumin interrupts the interaction between the androgen receptor and Wnt/beta-catenin signaling pathway in LNCaP prostate cancer cells.	Curcumin	0-8	androgen receptor	Homo sapiens	48-65
20680030-4	2010	Although curcumin has been shown to inhibit AR expression, its molecular mechanism has not been fully elucidated.	Curcumin	9-17	androgen receptor	Homo sapiens	44-46
20680030-6	2010	Curcumin was shown to induce significant inhibition of AR expression in a dose-dependent manner.	Curcumin	0-8	androgen receptor	Homo sapiens	55-57
20615395-11	2010	Treatment with AP-1 inhibitors (tanshinone IIA and curcumin) also reduced GDNF-induced glioma cell migration.	Curcumin	51-59	glial cell derived neurotrophic factor	Homo sapiens	74-78
20472336-0	2010	Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells.	Curcumin	0-8	tumor protein p53	Homo sapiens	48-51
20472336-3	2010	Curcumin killed wild-type p53 HCT-116 cells and mutant p53 HT-29 cells in a dose- and time-dependent manner.	Curcumin	0-8	tumor protein p53	Homo sapiens	26-29
20472336-3	2010	Curcumin killed wild-type p53 HCT-116 cells and mutant p53 HT-29 cells in a dose- and time-dependent manner.	Curcumin	0-8	tumor protein p53	Homo sapiens	55-58
20472336-5	2010	Similar results were obtained when the cytotoxic effect of curcumin was assessed in wild-type p53 HCT-116 cells after siRNA-mediated p53 knockdown.	Curcumin	59-67	tumor protein p53	Homo sapiens	94-97
20472336-5	2010	Similar results were obtained when the cytotoxic effect of curcumin was assessed in wild-type p53 HCT-116 cells after siRNA-mediated p53 knockdown.	Curcumin	59-67	tumor protein p53	Homo sapiens	133-136
20472336-6	2010	Chromatin condensation, poly (ADP-ribose) polymerase-1 cleavage and reduced pro-caspase-3 levels in curcumin-treated p53(+/+) and p53(-/-) HCT-116 cells suggested that curcumin caused apoptosis.	Curcumin	100-108	caspase 3	Homo sapiens	76-89
20472336-6	2010	Chromatin condensation, poly (ADP-ribose) polymerase-1 cleavage and reduced pro-caspase-3 levels in curcumin-treated p53(+/+) and p53(-/-) HCT-116 cells suggested that curcumin caused apoptosis.	Curcumin	100-108	tumor protein p53	Homo sapiens	117-120
20472336-6	2010	Chromatin condensation, poly (ADP-ribose) polymerase-1 cleavage and reduced pro-caspase-3 levels in curcumin-treated p53(+/+) and p53(-/-) HCT-116 cells suggested that curcumin caused apoptosis.	Curcumin	168-176	poly(ADP-ribose) polymerase 1	Homo sapiens	24-54
20472336-7	2010	In addition, exposure to curcumin resulted in superoxide anion production and phosphorylation of oxidative stress proteins in p53(+/+) and p53(-/-) HCT-116 cells.	Curcumin	25-33	tumor protein p53	Homo sapiens	126-129
20472336-7	2010	In addition, exposure to curcumin resulted in superoxide anion production and phosphorylation of oxidative stress proteins in p53(+/+) and p53(-/-) HCT-116 cells.	Curcumin	25-33	tumor protein p53	Homo sapiens	139-142
20958191-8	2010	Curcumin inhibited RPE cell increase exclusively by inducing caspase 3/7-dependent but caspase 8-independent cell death and necrosis.	Curcumin	0-8	caspase 3	Homo sapiens	61-70
20920780-0	2010	Curcumin attenuates the effects of transport stress on serum cortisol concentration, hippocampal NO production, and BDNF expression in the pig.	Curcumin	0-8	brain derived neurotrophic factor	Sus scrofa	116-120
20920780-6	2010	In addition, the stress-induced increase in the expression of constitutive nitric oxide synthase (cNOS) and enzyme activities of total NOS, cNOS, and inducible NOS (iNOS) was also reversed or attenuated in curcumin-treated pigs.	Curcumin	206-214	nitric oxide synthase 2	Sus scrofa	75-96
20920780-6	2010	In addition, the stress-induced increase in the expression of constitutive nitric oxide synthase (cNOS) and enzyme activities of total NOS, cNOS, and inducible NOS (iNOS) was also reversed or attenuated in curcumin-treated pigs.	Curcumin	206-214	nitric oxide synthase 2	Sus scrofa	150-163
20920780-6	2010	In addition, the stress-induced increase in the expression of constitutive nitric oxide synthase (cNOS) and enzyme activities of total NOS, cNOS, and inducible NOS (iNOS) was also reversed or attenuated in curcumin-treated pigs.	Curcumin	206-214	nitric oxide synthase 2	Sus scrofa	165-169
20920780-8	2010	These results suggest that curcumin can alleviate subacute stress response in pigs through its neuroprotective effects on modulating hippocampal NO production and BDNF expression.	Curcumin	27-35	brain derived neurotrophic factor	Sus scrofa	163-167
21141073-8	2010	The NF-kappaB inhibitor curcumin blocked the effects of TNF-alpha on both barrier functions and the subcellular distribution of ZO-1 at a late phase.	Curcumin	24-32	tumor necrosis factor	Homo sapiens	56-65
21141073-8	2010	The NF-kappaB inhibitor curcumin blocked the effects of TNF-alpha on both barrier functions and the subcellular distribution of ZO-1 at a late phase.	Curcumin	24-32	tight junction protein 1	Homo sapiens	128-132
20727390-2	2010	In order to improve the oral bioavailability of docetaxel, a component of turmeric, curcumin, which can down-regulate the intestinal P-glycoprotein and CYP3A protein levels, was used for the pre-treatment of rats before the oral administration of docetaxel.	Curcumin	84-92	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	152-157
20615389-0	2010	Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy.	Curcumin	52-60	mitogen-activated protein kinase 1	Homo sapiens	18-21
20878089-10	2010	Curcumin induced the unfolding protein response by down-regulating the protein expressions of Calnexin, PDI and Ero1-Lalpha and up-regulating the Calreticulin expression.	Curcumin	0-8	calreticulin	Homo sapiens	146-158
20878089-11	2010	Curcumin induces the GADD153 expression by cleaving caspase-12 and ATF6, and then by translocating ATF6 to the nucleus.	Curcumin	0-8	DNA damage inducible transcript 3	Homo sapiens	21-28
20878089-12	2010	Curcumin also down-regulates the protein expressions of TCTP, Mcl-1 and Bcl-2, in order to induce mitochondrial dysfunction.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	72-77
21472350-5	2010	Curcumin, a nuclear factor-kappaB (NF-kappaB) inhibitor, increased the sensitivity to irinotecan of A549/CTP-11R cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	35-44
20406252-5	2010	In in vitro studies, curcumin has been reported to inhibit amyloid-beta-protein (Abeta) aggregation, and Abeta-induced inflammation, as well as the activities of beta-secretase and acetylcholinesterase.	Curcumin	21-29	amyloid beta precursor protein	Homo sapiens	81-86
20655375-0	2010	Transferrin mediated solid lipid nanoparticles containing curcumin: enhanced in vitro anticancer activity by induction of apoptosis.	Curcumin	58-66	transferrin	Homo sapiens	0-11
20600877-0	2010	Curcumin p38-dependently enhances the anticancer activity of valproic acid in human leukemia cells.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	9-12
20600877-3	2010	Curcumin (Cur) is a promising natural anticancer agent that can specifically regulate the expression of NF-kappaB, bcl-2, and bax in leukemia cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	104-113
20600877-3	2010	Curcumin (Cur) is a promising natural anticancer agent that can specifically regulate the expression of NF-kappaB, bcl-2, and bax in leukemia cells.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	115-120
20600877-3	2010	Curcumin (Cur) is a promising natural anticancer agent that can specifically regulate the expression of NF-kappaB, bcl-2, and bax in leukemia cells.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	126-129
21036715-0	2010	Curcumin-altered p53-response genes regulate radiosensitivity in p53-mutant Ewing"s sarcoma cells.	Curcumin	0-8	tumor protein p53	Homo sapiens	17-20
21036715-0	2010	Curcumin-altered p53-response genes regulate radiosensitivity in p53-mutant Ewing"s sarcoma cells.	Curcumin	0-8	tumor protein p53	Homo sapiens	65-68
21036715-1	2010	AIM: Curcumin has been demonstrated to have antitumor effects including radiosensitization by modulating many molecular targets including p53.	Curcumin	5-13	tumor protein p53	Homo sapiens	138-141
21036715-2	2010	Herein, we investigated the radiosensitizing effect of curcumin in p53 mutant Ewing"s sarcoma (ES) cells.	Curcumin	55-63	tumor protein p53	Homo sapiens	67-70
21036715-4	2010	RESULTS: Curcumin significantly caused radiation induced expression of p21 and Bax, and reduced BclXl, Mcl1 with only marginal Bcl2 modulation.	Curcumin	9-17	BCL2 associated X, apoptosis regulator	Homo sapiens	79-82
21036715-4	2010	RESULTS: Curcumin significantly caused radiation induced expression of p21 and Bax, and reduced BclXl, Mcl1 with only marginal Bcl2 modulation.	Curcumin	9-17	BCL2 like 1	Homo sapiens	96-101
21036715-8	2010	CONCLUSION: These results suggest that curcumin potentially radiosensitizes p53-mutant ES cells by regulating IR-modulated p53-response genes.	Curcumin	39-47	tumor protein p53	Homo sapiens	76-79
21036715-8	2010	CONCLUSION: These results suggest that curcumin potentially radiosensitizes p53-mutant ES cells by regulating IR-modulated p53-response genes.	Curcumin	39-47	tumor protein p53	Homo sapiens	123-126
21036715-9	2010	However, the curcumin-associated p53-independent regulation of downstream targets remains to be explored.	Curcumin	13-21	tumor protein p53	Homo sapiens	33-36
20521051-8	2010	Curcumin itself promotes pro-apoptosis protein Caspase 3 and Caspase 9 cleavage and anti-apoptosis protein Bcl-XL and X-IAP degradation, and combination of C6 ceramide with curcumin dramatically enhances it.	Curcumin	0-8	caspase 3	Homo sapiens	47-56
20521051-8	2010	Curcumin itself promotes pro-apoptosis protein Caspase 3 and Caspase 9 cleavage and anti-apoptosis protein Bcl-XL and X-IAP degradation, and combination of C6 ceramide with curcumin dramatically enhances it.	Curcumin	0-8	BCL2 like 1	Homo sapiens	107-113
20406252-5	2010	In in vitro studies, curcumin has been reported to inhibit amyloid-beta-protein (Abeta) aggregation, and Abeta-induced inflammation, as well as the activities of beta-secretase and acetylcholinesterase.	Curcumin	21-29	amyloid beta precursor protein	Homo sapiens	105-110
20406252-6	2010	In in vivo studies, oral administration of curcumin has resulted in the inhibition of Abeta deposition, Abeta oligomerization, and tau phosphorylation in the brains of AD animal models, and improvements in behavioral impairment in animal models.	Curcumin	43-51	amyloid beta precursor protein	Homo sapiens	86-91
20406252-6	2010	In in vivo studies, oral administration of curcumin has resulted in the inhibition of Abeta deposition, Abeta oligomerization, and tau phosphorylation in the brains of AD animal models, and improvements in behavioral impairment in animal models.	Curcumin	43-51	amyloid beta precursor protein	Homo sapiens	104-109
20605902-4	2010	Curcumin plus ATO or lonidamine stimulates typical events of the mitochondrial executioner pathway (Bax and Bid activation, cytochrome c release, X-linked inhibitor of apoptosis down-regulation, and caspase-9/-3 activation) and causes mitochondrial transmembrane potential dissipation, which nevertheless represents a late event in the apoptotic response.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	100-103
20605902-4	2010	Curcumin plus ATO or lonidamine stimulates typical events of the mitochondrial executioner pathway (Bax and Bid activation, cytochrome c release, X-linked inhibitor of apoptosis down-regulation, and caspase-9/-3 activation) and causes mitochondrial transmembrane potential dissipation, which nevertheless represents a late event in the apoptotic response.	Curcumin	0-8	BH3 interacting domain death agonist	Homo sapiens	108-111
20605902-4	2010	Curcumin plus ATO or lonidamine stimulates typical events of the mitochondrial executioner pathway (Bax and Bid activation, cytochrome c release, X-linked inhibitor of apoptosis down-regulation, and caspase-9/-3 activation) and causes mitochondrial transmembrane potential dissipation, which nevertheless represents a late event in the apoptotic response.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	124-136
20937593-0	2010	Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma via inhibition of IKKbeta protein of the NFkappaB pathway.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	139-147
19826913-6	2010	A549 cells were treated with 0-240 muM curcumin for 4-96 h. The inhibitory effects of curcumin on cytotoxicity were dose- and time-dependent (P &lt; 0.001).	Curcumin	86-94	latexin	Homo sapiens	35-38
19826913-7	2010	The 50% inhibitory curcumin concentrations (IC50s) at 24, 48, 72, and 96 h were 93, 65, 40, and 24 muM, respectively.	Curcumin	19-27	latexin	Homo sapiens	99-102
20163327-0	2010	Curcumin inhibits TNFalpha-induced lectin-like oxidised LDL receptor-1 (LOX-1) expression and suppresses the inflammatory response in human umbilical vein endothelial cells (HUVECs) by an antioxidant mechanism.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	18-26
20937593-5	2010	Reduced expression of cyclin D1, IkappaBalpha, phospho-IkappaBalpha, and IKKbeta occurred in cisplatin- and curcumin-treated cell lines.	Curcumin	108-116	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	33-45
20937593-5	2010	Reduced expression of cyclin D1, IkappaBalpha, phospho-IkappaBalpha, and IKKbeta occurred in cisplatin- and curcumin-treated cell lines.	Curcumin	108-116	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	55-67
20937593-8	2010	Curcumin inhibited IKKbeta in the cytoplasm and nucleus, leading to reduced NFkappaB activity, with no effect on phospho-AKT.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-84
20937593-10	2010	The suppressive effect of curcumin was mediated through inhibition of cytoplasmic and nuclear IKKbeta, resulting in inhibition of NFkappaB activity.	Curcumin	26-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	130-138
20846156-9	2010	The addition of NAC, curcumin, PD98059, and staurosporine markedly inhibited the arecoline-induced HIF-1alpha expression (P&lt;0.05).	Curcumin	21-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-109
20846156-10	2010	CONCLUSIONS: Hypoxia inducible factor-1alpha expression is significantly upregulated in areca quid chewing-associated OSCC and HIF-1alpha expression induced by arecoline is downregulated by NAC, curcumin, PD98059, and staurosporine.	Curcumin	195-203	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-137
20806431-7	2010	The increased expression of COX-2 induced by deoxycholic acid was partially reversed by the addition of curcumin, and curcumin reduced COX-2 expression 3.3- to 1.3-fold.	Curcumin	104-112	prostaglandin-endoperoxide synthase 2	Homo sapiens	28-33
20840775-5	2010	Levels of the transcription factor phospho-STAT3, a potential target of Curcumin, were determined by sandwich-ELISA.	Curcumin	72-80	signal transducer and activator of transcription 3	Homo sapiens	43-48
20840775-9	2010	Simultaneously, levels of the biologically active phospho-STAT3 were decreased and correlated with reduced transcription of the cell cycle regulating gene c-Myc and proliferation marking Ki-67, pointing to a potential mechanism by which Curcumin slows tumor growth.	Curcumin	237-245	signal transducer and activator of transcription 3	Homo sapiens	58-63
20885979-8	2010	We found Curcumin decreased the levels of D-lactate, DAO, MPO, ICAM-1, IL-1beta and TNF-alpha, but increased the levels of IL-10 and SOD in rat models.	Curcumin	9-17	interleukin 1 beta	Rattus norvegicus	71-79
20885979-8	2010	We found Curcumin decreased the levels of D-lactate, DAO, MPO, ICAM-1, IL-1beta and TNF-alpha, but increased the levels of IL-10 and SOD in rat models.	Curcumin	9-17	tumor necrosis factor	Rattus norvegicus	84-93
20806431-7	2010	The increased expression of COX-2 induced by deoxycholic acid was partially reversed by the addition of curcumin, and curcumin reduced COX-2 expression 3.3- to 1.3-fold.	Curcumin	118-126	prostaglandin-endoperoxide synthase 2	Homo sapiens	135-140
20806431-9	2010	The addition of curcumin treatment partially reversed the bile acid-induced reduction in SOD-1 expression at all concentrations of curcumin tested.	Curcumin	16-24	superoxide dismutase 1	Homo sapiens	89-94
20806431-9	2010	The addition of curcumin treatment partially reversed the bile acid-induced reduction in SOD-1 expression at all concentrations of curcumin tested.	Curcumin	131-139	superoxide dismutase 1	Homo sapiens	89-94
20806431-10	2010	CONCLUSION: Curcumin reverses bile acid suppression of gene expression of SOD-1.	Curcumin	12-20	superoxide dismutase 1	Homo sapiens	74-79
20806431-11	2010	Curcumin is also able to inhibit bile acid induction of COX-2 gene expression.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	56-61
20553984-3	2010	Unlike free curcumin, it is readily dispersed in aqueous medium, showing narrow size distribution 192 nm ranges (as observed by microscope) with biocompatibility (confocal studies and TNF-alpha assay).	Curcumin	12-20	tumor necrosis factor	Mus musculus	184-193
20944094-0	2010	Transient metals enhance cytotoxicity of curcumin: potential involvement of the NF-kappaB and mTOR signaling pathways.	Curcumin	41-49	nuclear factor kappa B subunit 1	Homo sapiens	80-89
20944094-0	2010	Transient metals enhance cytotoxicity of curcumin: potential involvement of the NF-kappaB and mTOR signaling pathways.	Curcumin	41-49	mechanistic target of rapamycin kinase	Homo sapiens	94-98
20944094-6	2010	Curcumin plus Cu (II) enhanced intracellular copper levels and potentiated curcumin-induced suppression of the nuclear factor kappa B (NF-kappaB) pathway, as well as alterations of mammalian target of rapamycin-raptor (mTOR) signaling.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	111-133
20944094-6	2010	Curcumin plus Cu (II) enhanced intracellular copper levels and potentiated curcumin-induced suppression of the nuclear factor kappa B (NF-kappaB) pathway, as well as alterations of mammalian target of rapamycin-raptor (mTOR) signaling.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	135-144
20944094-6	2010	Curcumin plus Cu (II) enhanced intracellular copper levels and potentiated curcumin-induced suppression of the nuclear factor kappa B (NF-kappaB) pathway, as well as alterations of mammalian target of rapamycin-raptor (mTOR) signaling.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	181-217
20944094-6	2010	Curcumin plus Cu (II) enhanced intracellular copper levels and potentiated curcumin-induced suppression of the nuclear factor kappa B (NF-kappaB) pathway, as well as alterations of mammalian target of rapamycin-raptor (mTOR) signaling.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	219-223
20944094-6	2010	Curcumin plus Cu (II) enhanced intracellular copper levels and potentiated curcumin-induced suppression of the nuclear factor kappa B (NF-kappaB) pathway, as well as alterations of mammalian target of rapamycin-raptor (mTOR) signaling.	Curcumin	75-83	nuclear factor kappa B subunit 1	Homo sapiens	111-133
20944094-6	2010	Curcumin plus Cu (II) enhanced intracellular copper levels and potentiated curcumin-induced suppression of the nuclear factor kappa B (NF-kappaB) pathway, as well as alterations of mammalian target of rapamycin-raptor (mTOR) signaling.	Curcumin	75-83	nuclear factor kappa B subunit 1	Homo sapiens	135-144
20944094-6	2010	Curcumin plus Cu (II) enhanced intracellular copper levels and potentiated curcumin-induced suppression of the nuclear factor kappa B (NF-kappaB) pathway, as well as alterations of mammalian target of rapamycin-raptor (mTOR) signaling.	Curcumin	75-83	mechanistic target of rapamycin kinase	Homo sapiens	219-223
20944094-7	2010	CONCLUSION: Transient metals enhance the cytotoxicity of curcumin, likely through targeting of the NF-kappaB and mTOR signaling pathways.	Curcumin	57-65	nuclear factor kappa B subunit 1	Homo sapiens	99-108
20944094-7	2010	CONCLUSION: Transient metals enhance the cytotoxicity of curcumin, likely through targeting of the NF-kappaB and mTOR signaling pathways.	Curcumin	57-65	mechanistic target of rapamycin kinase	Homo sapiens	113-117
20535508-11	2010	FINDINGS: Curcumin treatment improved neurologic outcome, which was supported by decreased level of tissue MDA and increased levels of tissue GSH-Px, SOD, and CAT activity.	Curcumin	10-18	glutathione peroxidase 1	Rattus norvegicus	142-148
20535508-11	2010	FINDINGS: Curcumin treatment improved neurologic outcome, which was supported by decreased level of tissue MDA and increased levels of tissue GSH-Px, SOD, and CAT activity.	Curcumin	10-18	catalase	Rattus norvegicus	159-162
20535508-14	2010	By increasing tissue levels of GSH-Px, SOD, and CAT, curcumin seems to reduce the effects of injury to the spinal cord, which may be beneficial for neuronal survival.	Curcumin	53-61	glutathione peroxidase 1	Rattus norvegicus	31-37
20535508-14	2010	By increasing tissue levels of GSH-Px, SOD, and CAT, curcumin seems to reduce the effects of injury to the spinal cord, which may be beneficial for neuronal survival.	Curcumin	53-61	catalase	Rattus norvegicus	48-51
20812900-8	2010	Besides, some natural products, such as epigallocatechin gallate (EGCG), caffeine, curcumin and resveratrol, have been found to inhibit mTOR as well.	Curcumin	83-91	mechanistic target of rapamycin kinase	Homo sapiens	136-140
20726007-4	2010	Curcumin up-regulates caspase family proteins and down-regulates anti-apoptotic genes (Bcl-2 and Bcl-X(L)).	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	87-92
20726007-4	2010	Curcumin up-regulates caspase family proteins and down-regulates anti-apoptotic genes (Bcl-2 and Bcl-X(L)).	Curcumin	0-8	BCL2 like 1	Homo sapiens	97-105
20818158-8	2010	FLLL32 is a novel curcumin analogue, which has been described to suppress the constitutive activation of STAT3 in pancreatic and breast cancer cells in vitro and vivo.	Curcumin	18-26	signal transducer and activator of transcription 3	Homo sapiens	105-110
20513444-8	2010	Both Tyrphostin AG1478, an EGFR tyrosine kinase inhibitor, and curcumin, an inhibitor of both STAT3 and EGFR, attenuated STAT3 activation/nuclear translocation, reduced skin thickening, and partially suppressed the barrier abnormalities.	Curcumin	63-71	signal transducer and activator of transcription 3	Mus musculus	94-99
20712901-2	2010	A novel small molecular STAT3 inhibitor, FLLL32 was specifically designed from dietary agent, curcumin to inhibit constitutive STAT3 signaling in multiple myeloma, glioblastoma, liver cancer, and colorectal cancer cells.	Curcumin	94-102	signal transducer and activator of transcription 3	Homo sapiens	24-29
20712901-2	2010	A novel small molecular STAT3 inhibitor, FLLL32 was specifically designed from dietary agent, curcumin to inhibit constitutive STAT3 signaling in multiple myeloma, glioblastoma, liver cancer, and colorectal cancer cells.	Curcumin	94-102	signal transducer and activator of transcription 3	Homo sapiens	127-132
20731017-1	2010	AIM: To investigate whether curcumin could attenuate nuclear factor (NF)-kappaB p65 expression and macromolecular leakage in the gastric mucosa of Helicobacter pylori (H. pylori)-infected rats.	Curcumin	28-36	synaptotagmin 1	Rattus norvegicus	80-83
20731017-8	2010	Curcumin supplementation in Hp + curI and Hp + curII groups significantly decreased NF-kappaB p65 immunoreactive cells and macromolecular leakage compared with results in the Hp group.	Curcumin	0-8	synaptotagmin 1	Rattus norvegicus	94-97
20513444-8	2010	Both Tyrphostin AG1478, an EGFR tyrosine kinase inhibitor, and curcumin, an inhibitor of both STAT3 and EGFR, attenuated STAT3 activation/nuclear translocation, reduced skin thickening, and partially suppressed the barrier abnormalities.	Curcumin	63-71	signal transducer and activator of transcription 3	Mus musculus	121-126
20538607-0	2010	Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.	Curcumin	70-78	nuclear factor kappa B subunit 1	Homo sapiens	14-22
20538607-3	2010	In addition, curcumin decreased expression of p50 and p65 proteins and NFkappaB-dependent transactivation and also decreased Sp1, Sp3, and Sp4 transcription factors that are overexpressed in pancreatic cancer cells.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	46-49
20538607-5	2010	Results of Sp1, Sp3, and Sp4 knockdown by RNA interference demonstrate that both p50 and p65 are Sp-regulated genes and that inhibition of constitutive or tumor necrosis factor-induced NFkappaB by curcumin is dependent on down-regulation of Sp1, Sp3, and Sp4 proteins by this compound.	Curcumin	197-205	nuclear factor kappa B subunit 1	Homo sapiens	81-84
20538607-5	2010	Results of Sp1, Sp3, and Sp4 knockdown by RNA interference demonstrate that both p50 and p65 are Sp-regulated genes and that inhibition of constitutive or tumor necrosis factor-induced NFkappaB by curcumin is dependent on down-regulation of Sp1, Sp3, and Sp4 proteins by this compound.	Curcumin	197-205	nuclear factor kappa B subunit 1	Homo sapiens	185-193
20538607-3	2010	In addition, curcumin decreased expression of p50 and p65 proteins and NFkappaB-dependent transactivation and also decreased Sp1, Sp3, and Sp4 transcription factors that are overexpressed in pancreatic cancer cells.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	71-79
20538607-5	2010	Results of Sp1, Sp3, and Sp4 knockdown by RNA interference demonstrate that both p50 and p65 are Sp-regulated genes and that inhibition of constitutive or tumor necrosis factor-induced NFkappaB by curcumin is dependent on down-regulation of Sp1, Sp3, and Sp4 proteins by this compound.	Curcumin	197-205	Sp3 transcription factor	Homo sapiens	246-249
20538607-3	2010	In addition, curcumin decreased expression of p50 and p65 proteins and NFkappaB-dependent transactivation and also decreased Sp1, Sp3, and Sp4 transcription factors that are overexpressed in pancreatic cancer cells.	Curcumin	13-21	Sp3 transcription factor	Homo sapiens	130-133
20393484-0	2010	Curcumin selectively induces apoptosis in cutaneous T-cell lymphoma cell lines and patients" PBMCs: potential role for STAT-3 and NF-kappaB signaling.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	119-125
20638958-7	2010	And the contents of p-AKT decreased significantly after iAbeta treatment, while administration of curcumin significantly inhibited the iAbeta-induced decreases in the contents of p-AKT.	Curcumin	98-106	AKT serine/threonine kinase 1	Rattus norvegicus	181-184
20638958-8	2010	The results suggest that curcumin may play a protective effect in primary cultured rat prefrontal cortical neurons against iAbeta-induced cytotoxicity, and both AKT and caspase-3 are involved in the curcumin-induced protective effects.	Curcumin	199-207	AKT serine/threonine kinase 1	Rattus norvegicus	161-164
20599422-0	2010	Curcumin decreases toll-like receptor-2 gene expression and function in human monocytes and neutrophils.	Curcumin	0-8	toll like receptor 2	Homo sapiens	19-39
20599422-3	2010	Here, we showed that curcumin, a well-known anti-inflammatory agent derived from the curry spice turmeric, inhibits TLR2 expression in various TLR2-expressing innate immune cell lines such as monocytic THP-1 cells, neutrophilic-differentiated HL-60 cells.	Curcumin	21-29	toll like receptor 2	Homo sapiens	116-120
20599422-3	2010	Here, we showed that curcumin, a well-known anti-inflammatory agent derived from the curry spice turmeric, inhibits TLR2 expression in various TLR2-expressing innate immune cell lines such as monocytic THP-1 cells, neutrophilic-differentiated HL-60 cells.	Curcumin	21-29	toll like receptor 2	Homo sapiens	143-147
20599422-4	2010	Strong suppression of TLR2 gene expression was specifically observed at concentrations of curcumin in the range 40-100muM.	Curcumin	90-98	toll like receptor 2	Homo sapiens	22-26
20599422-5	2010	Consistent with decreased expression of TLR2 mRNA, protein expression and ligand-responsiveness of TLR2 were markedly reduced by curcumin treatment.	Curcumin	129-137	toll like receptor 2	Homo sapiens	40-44
20599422-5	2010	Consistent with decreased expression of TLR2 mRNA, protein expression and ligand-responsiveness of TLR2 were markedly reduced by curcumin treatment.	Curcumin	129-137	toll like receptor 2	Homo sapiens	99-103
20599422-6	2010	Moreover, curcumin-dependent down-regulation of TLR2 expression and function was also observed in primary peripheral blood monocytes (MC) and polymorphonuclear neutrophils (PMN).	Curcumin	10-18	toll like receptor 2	Homo sapiens	48-52
20599422-7	2010	Finally, we determined the importance of curcumin-dependent radical generation for the suppressive effect of curcumin on TLR2 expression.	Curcumin	41-49	toll like receptor 2	Homo sapiens	121-125
20599422-7	2010	Finally, we determined the importance of curcumin-dependent radical generation for the suppressive effect of curcumin on TLR2 expression.	Curcumin	109-117	toll like receptor 2	Homo sapiens	121-125
20599422-8	2010	Thus, our data demonstrate that curcumin inhibits TLR2 gene expression and function possibly via an oxidative process.	Curcumin	32-40	toll like receptor 2	Homo sapiens	50-54
20561944-6	2010	From this, curcumin treatment strongly induced glucose uptake and the phosphorylation of AMPK (AMP-activated protein kinase)/ACC (acetyl-CoA carboxylase), but not PI3-kinase (phosphoinositide 3-kinase)/Akt.	Curcumin	11-19	thymoma viral proto-oncogene 1	Mus musculus	202-205
20561944-7	2010	Interestingly, the co-treatment of insulin and curcumin produced a mutual synergistic activation of both AMPK/ACC and PI3-kinase/Akt pathways.	Curcumin	47-55	thymoma viral proto-oncogene 1	Mus musculus	129-132
20596601-10	2010	In the core signaling pathways of glioblastoma, curcumin either significantly influences the p53 pathway by enhancing p53 and p21 and suppressing cdc2 or significantly inhibits the RB pathway by enhancing CDKN2A/p16 and suppressing phosphorylated RB.	Curcumin	48-56	tumor protein p53	Homo sapiens	93-96
20596601-10	2010	In the core signaling pathways of glioblastoma, curcumin either significantly influences the p53 pathway by enhancing p53 and p21 and suppressing cdc2 or significantly inhibits the RB pathway by enhancing CDKN2A/p16 and suppressing phosphorylated RB.	Curcumin	48-56	tumor protein p53	Homo sapiens	118-121
20596601-10	2010	In the core signaling pathways of glioblastoma, curcumin either significantly influences the p53 pathway by enhancing p53 and p21 and suppressing cdc2 or significantly inhibits the RB pathway by enhancing CDKN2A/p16 and suppressing phosphorylated RB.	Curcumin	48-56	cyclin dependent kinase inhibitor 2A	Homo sapiens	205-211
20596601-10	2010	In the core signaling pathways of glioblastoma, curcumin either significantly influences the p53 pathway by enhancing p53 and p21 and suppressing cdc2 or significantly inhibits the RB pathway by enhancing CDKN2A/p16 and suppressing phosphorylated RB.	Curcumin	48-56	cyclin dependent kinase inhibitor 2A	Homo sapiens	212-215
20596601-11	2010	In the apoptotic pathway, the Bax and caspase 3 are significantly suppressed by curcumin and the Giemsa stain elucidates apoptotic features of DBTRG cells as well.	Curcumin	80-88	BCL2 associated X, apoptosis regulator	Homo sapiens	30-33
20596601-11	2010	In the apoptotic pathway, the Bax and caspase 3 are significantly suppressed by curcumin and the Giemsa stain elucidates apoptotic features of DBTRG cells as well.	Curcumin	80-88	caspase 3	Homo sapiens	38-47
20510329-9	2010	Curcumin also induced Nrf2 protein expression with up-regulation of gamma-glutamylcysteine ligase mRNA and increased cellular antioxidant, glutathione.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
20393484-6	2010	Curcumin decreased protein and mRNA expression levels of signal transducer and activator of transcription (STAT)-3, bcl-2, and survivin in three cell lines and in patients" PBMCs.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	57-114
20393484-6	2010	Curcumin decreased protein and mRNA expression levels of signal transducer and activator of transcription (STAT)-3, bcl-2, and survivin in three cell lines and in patients" PBMCs.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	116-121
20393484-7	2010	Curcumin inhibited STAT-3 and IkappaB-alpha phosphorylation, as well as suppressed DNA binding of nuclear factor (NF)-kappaB in these cells.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	19-25
20393484-7	2010	Curcumin inhibited STAT-3 and IkappaB-alpha phosphorylation, as well as suppressed DNA binding of nuclear factor (NF)-kappaB in these cells.	Curcumin	0-8	NFKB inhibitor alpha	Homo sapiens	30-43
20393484-8	2010	Caspase-3 was activated and poly (ADP-Ribose) polymerase was cleaved after curcumin treatment.	Curcumin	75-83	caspase 3	Homo sapiens	0-9
20393484-8	2010	Caspase-3 was activated and poly (ADP-Ribose) polymerase was cleaved after curcumin treatment.	Curcumin	75-83	poly(ADP-ribose) polymerase 1	Homo sapiens	28-56
20393484-9	2010	These data suggest that curcumin selectively induces apoptosis in association with the downregulation of STAT-3 and NF-kappaB signaling pathways in CTCL cells.	Curcumin	24-32	signal transducer and activator of transcription 3	Homo sapiens	105-111
20690979-6	2010	P-selectin expression in mice with CLP + curcumin was significantly attenuated compared with CLP in various microcirculatory beds, including brain.	Curcumin	41-49	selectin, platelet	Mus musculus	0-10
20690979-8	2010	CONCLUSION: Curcumin pre-treatment modulates leukocyte and platelet adhesion and BBB dysfunction in mice with CLP via P-selectin expression and improves survival in mice with CLP.	Curcumin	12-20	selectin, platelet	Mus musculus	118-128
20385124-0	2010	Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells.	Curcumin	0-8	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	36-40
20437093-2	2010	Here we evaluated if the Nrf2 activator curcumin affects basal and stimulated (Ca(2+) omission) GSH efflux from cultures of astroglial cells.	Curcumin	40-48	NFE2 like bZIP transcription factor 2	Homo sapiens	25-29
20437093-7	2010	RNAi directed against Nrf2 partly inhibited the effect of curcumin.	Curcumin	58-66	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
20385124-0	2010	Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	64-68
20385124-3	2010	In this study, we observed a dose- and time-dependent down-regulation of expression of EZH2 by curcumin that correlates with decreased proliferation in the MDA-MB-435 breast cancer cell line.	Curcumin	95-103	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	87-91
20385124-5	2010	Further investigation revealed that curcumin-induced down-regulation of EZH2 through stimulation of three major members of the mitogen-activated protein kinase (MAPK) pathway: c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 kinase.	Curcumin	36-44	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	72-76
20385124-5	2010	Further investigation revealed that curcumin-induced down-regulation of EZH2 through stimulation of three major members of the mitogen-activated protein kinase (MAPK) pathway: c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 kinase.	Curcumin	36-44	mitogen-activated protein kinase 1	Homo sapiens	161-165
20385124-5	2010	Further investigation revealed that curcumin-induced down-regulation of EZH2 through stimulation of three major members of the mitogen-activated protein kinase (MAPK) pathway: c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 kinase.	Curcumin	36-44	mitogen-activated protein kinase 8	Homo sapiens	176-201
20385124-5	2010	Further investigation revealed that curcumin-induced down-regulation of EZH2 through stimulation of three major members of the mitogen-activated protein kinase (MAPK) pathway: c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 kinase.	Curcumin	36-44	mitogen-activated protein kinase 8	Homo sapiens	203-206
20385124-5	2010	Further investigation revealed that curcumin-induced down-regulation of EZH2 through stimulation of three major members of the mitogen-activated protein kinase (MAPK) pathway: c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 kinase.	Curcumin	36-44	mitogen-activated protein kinase 1	Homo sapiens	209-246
20385124-5	2010	Further investigation revealed that curcumin-induced down-regulation of EZH2 through stimulation of three major members of the mitogen-activated protein kinase (MAPK) pathway: c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 kinase.	Curcumin	36-44	mitogen-activated protein kinase 1	Homo sapiens	248-251
20385124-5	2010	Further investigation revealed that curcumin-induced down-regulation of EZH2 through stimulation of three major members of the mitogen-activated protein kinase (MAPK) pathway: c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38 kinase.	Curcumin	36-44	mitogen-activated protein kinase 1	Homo sapiens	257-260
20385124-6	2010	These data suggest that an underlying mechanism of the MAPK pathway mediates the down-regulation of EZH2, thus contributing to the anti-proliferative effects of curcumin against breast cancer.	Curcumin	161-169	mitogen-activated protein kinase 1	Homo sapiens	55-59
20385124-6	2010	These data suggest that an underlying mechanism of the MAPK pathway mediates the down-regulation of EZH2, thus contributing to the anti-proliferative effects of curcumin against breast cancer.	Curcumin	161-169	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	100-104
20582811-5	2010	The natural products curcumin, resveratrol and parthenolide are known inhibitors of the activation of NF-kappaB.	Curcumin	21-29	nuclear factor kappa B subunit 1	Homo sapiens	102-111
20127863-0	2010	Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPalpha during oral cancer suppression.	Curcumin	0-8	insulin-like growth factor binding protein 5	Mus musculus	21-65
20127863-0	2010	Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPalpha during oral cancer suppression.	Curcumin	0-8	insulin-like growth factor binding protein 5	Mus musculus	67-74
20127863-3	2010	We identified curcumin as an inducer of IGFBP-5 expression in multiple types of oral keratinocytes; furthermore, curcumin induces IGFBP-5 promoter activity in SAS oral cancer cells.	Curcumin	14-22	insulin-like growth factor binding protein 5	Mus musculus	40-47
20127863-3	2010	We identified curcumin as an inducer of IGFBP-5 expression in multiple types of oral keratinocytes; furthermore, curcumin induces IGFBP-5 promoter activity in SAS oral cancer cells.	Curcumin	113-121	insulin-like growth factor binding protein 5	Mus musculus	130-137
20127863-4	2010	Promoter deletion mapping identified a region (nt -71 to nt -59 relative to the transcription start site) as containing a C/EBPalpha-binding element that is indispensable for curcumin-mediated IGFBP-5 upregulation.	Curcumin	175-183	insulin-like growth factor binding protein 5	Mus musculus	193-200
20127863-6	2010	Curcumin increased nuclear C/EBPalpha expression and IGFBP-5 expression through p38 activation and this was abrogated by SB203580 treatment.	Curcumin	0-8	insulin-like growth factor binding protein 5	Mus musculus	53-60
20127863-8	2010	Finally, curcumin-induced IGFBP-5 expression is associated with the suppression of xenograft tumorigenesis in mice due to oral cancer cells.	Curcumin	9-17	insulin-like growth factor binding protein 5	Mus musculus	26-33
20127863-9	2010	We conclude that curcumin activates p38, which, in turn, activates the C/EBPalpha transactivator by interacting with binding elements in the IGFBP-5 promoter.	Curcumin	17-25	insulin-like growth factor binding protein 5	Mus musculus	141-148
20127863-10	2010	The consequential upregulation of C/EBPalpha and IGFBP-5 by curcumin is crucial to the suppression of oral carcinogenesis.	Curcumin	60-68	insulin-like growth factor binding protein 5	Mus musculus	49-56
20462637-7	2010	Co-expression of I kappaB alpha inhibited p65-mediated FOXP3 proximal promoter transactivation, and the NF-kappaB inhibitor curcumin reduced Foxp3 neoexpression in IL-2/CD3/CD28/TGF-beta stimulated PBMCs.	Curcumin	124-132	interleukin 2	Homo sapiens	164-168
20462637-7	2010	Co-expression of I kappaB alpha inhibited p65-mediated FOXP3 proximal promoter transactivation, and the NF-kappaB inhibitor curcumin reduced Foxp3 neoexpression in IL-2/CD3/CD28/TGF-beta stimulated PBMCs.	Curcumin	124-132	transforming growth factor beta 1	Homo sapiens	178-186
20683022-0	2010	Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin.	Curcumin	0-8	cadherin 1	Mus musculus	99-109
20683022-4	2010	We hypothesized that suppressing NF-kappaB by curcumin could up-regulate E-cadherin expression in NPC cells.	Curcumin	46-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	33-42
20683022-4	2010	We hypothesized that suppressing NF-kappaB by curcumin could up-regulate E-cadherin expression in NPC cells.	Curcumin	46-54	cadherin 1	Mus musculus	73-83
20683022-8	2010	RESULTS: With curcumin treatment, NF-kappaB was down-regulated and E-cadherin was up-regulated in NPC cells.	Curcumin	14-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	34-43
20683022-8	2010	RESULTS: With curcumin treatment, NF-kappaB was down-regulated and E-cadherin was up-regulated in NPC cells.	Curcumin	14-22	cadherin 1	Mus musculus	67-77
20683022-10	2010	CONCLUSION: Our results suggest that curcumin could be used in preventing NPC migration by suppressing NF-kappaB and activating E-cadherin expression.	Curcumin	37-45	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	103-112
20683022-10	2010	CONCLUSION: Our results suggest that curcumin could be used in preventing NPC migration by suppressing NF-kappaB and activating E-cadherin expression.	Curcumin	37-45	cadherin 1	Mus musculus	128-138
20305684-10	2010	Curcumin, however, inhibited the suppressive activity of Treg cells by downregulating the production of TGF-beta and IL-10 in these cells.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	104-112
20514428-4	2010	In addition, the expression of melanogenesis-related proteins such as microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein 1 and 2 was suppressed by curcumin in the alpha-MSH-stimulated B16F10 cells.	Curcumin	194-202	melanogenesis associated transcription factor	Mus musculus	70-116
20514428-4	2010	In addition, the expression of melanogenesis-related proteins such as microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein 1 and 2 was suppressed by curcumin in the alpha-MSH-stimulated B16F10 cells.	Curcumin	194-202	melanogenesis associated transcription factor	Mus musculus	118-122
20514428-5	2010	Notably, a melanogenesis-regulating signal such as mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) or phosphatidylinositol 3-kinase (PI3K)/Akt was activated by curcumin in the B16F10 cells treated with or without alpha-MSH.	Curcumin	202-210	mitogen-activated protein kinase 1	Mus musculus	136-139
20514428-5	2010	Notably, a melanogenesis-regulating signal such as mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) or phosphatidylinositol 3-kinase (PI3K)/Akt was activated by curcumin in the B16F10 cells treated with or without alpha-MSH.	Curcumin	202-210	thymoma viral proto-oncogene 1	Mus musculus	181-184
20514428-7	2010	Our results suggest that the suppressive activity of curcumin on alpha-MSH-stimulated melanogenesis may involve the down-regulation of MITF and its downstream signal pathway through the activation of MEK/ERK or PI3K/Akt.	Curcumin	53-61	melanogenesis associated transcription factor	Mus musculus	135-139
20514428-7	2010	Our results suggest that the suppressive activity of curcumin on alpha-MSH-stimulated melanogenesis may involve the down-regulation of MITF and its downstream signal pathway through the activation of MEK/ERK or PI3K/Akt.	Curcumin	53-61	mitogen-activated protein kinase 1	Mus musculus	204-207
20514428-7	2010	Our results suggest that the suppressive activity of curcumin on alpha-MSH-stimulated melanogenesis may involve the down-regulation of MITF and its downstream signal pathway through the activation of MEK/ERK or PI3K/Akt.	Curcumin	53-61	thymoma viral proto-oncogene 1	Mus musculus	216-219
20299603-8	2010	We have demonstrated that exposure of HIMEC to low levels of irradiation induced Akt and mTOR phosphorylation, which was attenuated by curcumin, rapamycin, LY294002, and mTOR small interference RNA (siRNA).	Curcumin	135-143	AKT serine/threonine kinase 1	Homo sapiens	81-84
20299603-8	2010	We have demonstrated that exposure of HIMEC to low levels of irradiation induced Akt and mTOR phosphorylation, which was attenuated by curcumin, rapamycin, LY294002, and mTOR small interference RNA (siRNA).	Curcumin	135-143	mechanistic target of rapamycin kinase	Homo sapiens	89-93
20299603-10	2010	Curcumin also induced apoptosis by induction of caspase-3 cleavage in irradiated HIMEC.	Curcumin	0-8	caspase 3	Homo sapiens	48-57
20576164-0	2010	The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity.	Curcumin	19-27	signal transducer and activator of transcription 3	Homo sapiens	82-87
20576164-1	2010	BACKGROUND: We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin.	Curcumin	141-149	signal transducer and activator of transcription 3	Homo sapiens	76-81
20403340-7	2010	Curcumin (10 microg/ml) was found to significantly inhibit the apoptosis of preOL and expression of either iNOS or NOX in the LPS-activated microglia.	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	107-111
20403340-10	2010	Treatment with curcumin either 1h before or immediately after LPS injection significantly ameliorated white matter injury and loss of preOLs, decreased activated microglia, and inhibited microglial expression of iNOS and translocation of p67phox and gp91phox to the microglial cell membranes in neonatal rat brains following LPS injection.	Curcumin	15-23	nitric oxide synthase 2	Rattus norvegicus	212-216
20403340-11	2010	These results suggest that curcumin has a protective effect on infection-driven white matter injury, which is associated with suppression of iNOS and NOX activation.	Curcumin	27-35	nitric oxide synthase 2	Rattus norvegicus	141-145
20302927-9	2010	Treatment with the AP1 inhibitor curcumin prevented H(2)O(2)-mediated reductions in PPAR gamma expression.	Curcumin	33-41	peroxisome proliferator activated receptor gamma	Homo sapiens	84-94
20299603-11	2010	In conclusion, curcumin significantly inhibited NF-kappaB and attenuated the effect of irradiation-induced prosurvival signaling through the PI3K/Akt/mTOR and NF-kappaB pathways in these gut-specific endothelial cells.	Curcumin	15-23	AKT serine/threonine kinase 1	Homo sapiens	146-149
20299603-11	2010	In conclusion, curcumin significantly inhibited NF-kappaB and attenuated the effect of irradiation-induced prosurvival signaling through the PI3K/Akt/mTOR and NF-kappaB pathways in these gut-specific endothelial cells.	Curcumin	15-23	mechanistic target of rapamycin kinase	Homo sapiens	150-154
20357182-0	2010	Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/beta-catenin signaling.	Curcumin	0-8	wingless-type MMTV integration site family, member 10B	Mus musculus	91-94
20357182-5	2010	During differentiation, curcumin also restored nuclear translocation of the integral Wnt signaling component beta-catenin in a dose-dependent manner.	Curcumin	24-32	wingless-type MMTV integration site family, member 10B	Mus musculus	85-88
20357182-7	2010	Accordingly, quantitative PCR analysis revealed that curcumin inhibited the mRNA expression of AP2 (mature adipocyte marker) and increased the mRNA expression of Wnt10b, Fz2 (Wnt direct receptor), and LRP5 (Wnt coreceptor).	Curcumin	53-61	wingless-type MMTV integration site family, member 10B	Mus musculus	162-168
20230014-0	2010	ApoE3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin: study of enhanced activity of curcumin against beta amyloid induced cytotoxicity using in vitro cell culture model.	Curcumin	66-74	apolipoprotein E	Homo sapiens	0-5
20230014-0	2010	ApoE3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin: study of enhanced activity of curcumin against beta amyloid induced cytotoxicity using in vitro cell culture model.	Curcumin	106-114	apolipoprotein E	Homo sapiens	0-5
20357182-8	2010	Curcumin also increased mRNA levels of c-Myc and cyclin D1, well-known Wnt targets.	Curcumin	0-8	wingless-type MMTV integration site family, member 10B	Mus musculus	71-74
20230014-4	2010	In the present study, we have formulated apolipoprotein E3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin (ApoE3-C-PBCA) to provide photostability and enhanced cell uptake of curcumin by targeting.	Curcumin	119-127	apolipoprotein E	Homo sapiens	41-58
20230014-4	2010	In the present study, we have formulated apolipoprotein E3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin (ApoE3-C-PBCA) to provide photostability and enhanced cell uptake of curcumin by targeting.	Curcumin	119-127	apolipoprotein E	Homo sapiens	129-134
20357182-9	2010	These results suggest that the Wnt signaling pathway participates in curcumin-induced suppression of adipogenesis in 3T3-L1 cells.	Curcumin	69-77	wingless-type MMTV integration site family, member 10B	Mus musculus	31-34
20230014-4	2010	In the present study, we have formulated apolipoprotein E3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin (ApoE3-C-PBCA) to provide photostability and enhanced cell uptake of curcumin by targeting.	Curcumin	197-205	apolipoprotein E	Homo sapiens	41-58
20230014-4	2010	In the present study, we have formulated apolipoprotein E3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin (ApoE3-C-PBCA) to provide photostability and enhanced cell uptake of curcumin by targeting.	Curcumin	197-205	apolipoprotein E	Homo sapiens	129-134
20456495-5	2010	Primary human keratinocytes treated with curcumin or THC demonstrated decreased activation of p44/42 MAP kinases but increased levels of activated p38 MAP kinases.	Curcumin	41-49	mitogen-activated protein kinase 14	Homo sapiens	147-150
20230014-9	2010	In vitro cell culture study showed enhanced therapeutic efficacy of ApoE3-C-PBCA against beta amyloid induced cytotoxicity in SH-SY5Y neuroblastoma cells compared to plain curcumin solution.	Curcumin	172-180	apolipoprotein E	Homo sapiens	68-73
20230014-11	2010	From all the experiments, it was found that the activity of curcumin was enhanced with ApoE3-C-PBCA compared to plain curcumin solution suggesting enhanced cell uptake and a sustained drug release effect.	Curcumin	60-68	apolipoprotein E	Homo sapiens	87-92
20230014-13	2010	It was found that ApoE3 did indeed have activity against beta amyloid induced cytotoxicity along with curcumin.	Curcumin	102-110	apolipoprotein E	Homo sapiens	18-23
20651361-6	2010	After curcumin treatment, BAX and BAD were up-regulated, BCL-2, BCL-X(L) and XIAP were down-regulated.	Curcumin	6-14	BCL2 associated X, apoptosis regulator	Homo sapiens	26-29
20651361-6	2010	After curcumin treatment, BAX and BAD were up-regulated, BCL-2, BCL-X(L) and XIAP were down-regulated.	Curcumin	6-14	BCL2 apoptosis regulator	Homo sapiens	57-62
20651361-6	2010	After curcumin treatment, BAX and BAD were up-regulated, BCL-2, BCL-X(L) and XIAP were down-regulated.	Curcumin	6-14	BCL2 like 1	Homo sapiens	64-72
20651361-9	2010	Curcumin-induced apoptosis was also stimulated through the FAS/caspase-8 (extrinsic) pathway and ER stress proteins, growth arrest- and DNA damage-inducible gene 153 (GADD153) and glucose-regulated protein 78 (GRP78) were activated in the NCI-H460 cells.	Curcumin	0-8	DNA damage inducible transcript 3	Homo sapiens	117-165
20651361-9	2010	Curcumin-induced apoptosis was also stimulated through the FAS/caspase-8 (extrinsic) pathway and ER stress proteins, growth arrest- and DNA damage-inducible gene 153 (GADD153) and glucose-regulated protein 78 (GRP78) were activated in the NCI-H460 cells.	Curcumin	0-8	DNA damage inducible transcript 3	Homo sapiens	167-174
20651361-9	2010	Curcumin-induced apoptosis was also stimulated through the FAS/caspase-8 (extrinsic) pathway and ER stress proteins, growth arrest- and DNA damage-inducible gene 153 (GADD153) and glucose-regulated protein 78 (GRP78) were activated in the NCI-H460 cells.	Curcumin	0-8	heat shock protein family A (Hsp70) member 5	Homo sapiens	180-208
20651361-9	2010	Curcumin-induced apoptosis was also stimulated through the FAS/caspase-8 (extrinsic) pathway and ER stress proteins, growth arrest- and DNA damage-inducible gene 153 (GADD153) and glucose-regulated protein 78 (GRP78) were activated in the NCI-H460 cells.	Curcumin	0-8	heat shock protein family A (Hsp70) member 5	Homo sapiens	210-215
20565374-5	2010	In contrast, curcumin exerted only a marginal effect on interleukin 4 expression.	Curcumin	13-21	interleukin 4	Homo sapiens	56-69
20565374-6	2010	Interestingly, curcumin was found to inhibit nuclear factor kappa beta activation by blocking the degradation of the inhibitory unit I kappa B alpha.	Curcumin	15-23	NFKB inhibitor alpha	Homo sapiens	133-148
20607063-2	2010	The aim of this study was to investigate further the potential mechanism in the hypocholesterolemic effect of curcumin by measuring cholesterol 7a-hydroxylase (CYP7A1), a rate limiting enzyme in the biosynthesis of bile acid from cholesterol, at the mRNA level.	Curcumin	110-118	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	160-166
20205235-0	2010	Curcumin stimulates glucose uptake through AMPK-p38 MAPK pathways in L6 myotube cells.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	48-51
20205235-4	2010	In addition, curcumin activated the mitogen-activated protein kinase kinase (MEK)3/6-p38 mitogen-activated protein kinase (MAPK) signaling pathways in the downstream of the AMPK cascade.	Curcumin	13-21	mitogen-activated protein kinase 14	Homo sapiens	85-88
20205235-5	2010	Moreover, inhibition of either AMPK or p38 MAPK resulted in blockage of curcumin-induced glucose uptake.	Curcumin	72-80	mitogen-activated protein kinase 14	Homo sapiens	39-42
20205235-7	2010	Taken together, these results indicate that the beneficial health effect of curcumin can be explained by its ability to activate AMPK-p38 MAPK pathways in skeletal muscles.	Curcumin	76-84	mitogen-activated protein kinase 14	Homo sapiens	134-137
20200402-2	2010	The PGN-induced COX-2 expression was attenuated by the DNs of ASK1, JNK1, JNK2, a JNK inhibitor (SP600125), and an AP-1 inhibitor (curcumin).	Curcumin	131-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-21
20025056-0	2010	Curcumin protects against hepatic and renal injuries mediated by inducible nitric oxide synthase during selenium-induced toxicity in Wistar rats.	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	65-96
20025056-8	2010	To understand the probable mechanism of action of curcumin, we analyzed inducible nitric oxide synthase (iNOS) expression by immunohistochemistry, and the results showed an increased iNOS expression in selenium-alone induced liver and kidney.	Curcumin	50-58	nitric oxide synthase 2	Rattus norvegicus	72-103
20025056-8	2010	To understand the probable mechanism of action of curcumin, we analyzed inducible nitric oxide synthase (iNOS) expression by immunohistochemistry, and the results showed an increased iNOS expression in selenium-alone induced liver and kidney.	Curcumin	50-58	nitric oxide synthase 2	Rattus norvegicus	183-187
20025056-9	2010	Such high iNOS levels were inhibited in liver and kidney of rats pretreated with curcumin and then with selenium 24 h later.	Curcumin	81-89	nitric oxide synthase 2	Rattus norvegicus	10-14
20025056-10	2010	Based on the histological results, it can be concluded that curcumin functions as a protective agent against selenium-induced toxicity in liver as well as kidney, and this action is probably by the regulatory role of curcumin on iNOS expression.	Curcumin	60-68	nitric oxide synthase 2	Rattus norvegicus	229-233
20025056-10	2010	Based on the histological results, it can be concluded that curcumin functions as a protective agent against selenium-induced toxicity in liver as well as kidney, and this action is probably by the regulatory role of curcumin on iNOS expression.	Curcumin	217-225	nitric oxide synthase 2	Rattus norvegicus	229-233
20607063-8	2010	The curcumin diet up-regulated hepatic CYP7A1 mRNA level by 2.16-fold, compared to control group p (P &lt; 0.05).	Curcumin	4-12	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	39-45
20607063-9	2010	These findings suggested that the increases in the CYP7A1 gene expression may partially account for the hypocholesterolemic effect of curcumin.	Curcumin	134-142	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	51-57
20235152-0	2010	Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	47-53
20235152-8	2010	Overexpression of SOCS-3 in curcumin-treated cells increased expression of phosphorylated STAT-3 and resulted in increased cell viability.	Curcumin	28-36	signal transducer and activator of transcription 3	Homo sapiens	90-96
20235152-10	2010	Curcumin increased PIAS-3 expression in cancer cells.	Curcumin	0-8	protein inhibitor of activated STAT 3	Homo sapiens	19-25
20235152-0	2010	Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	102-108
20235152-11	2010	Of significance, siRNA-mediated knockdown of PIAS-3 overcomes the inhibitory effect of curcumin on STAT-3 phosphorylation and cell viability.	Curcumin	87-95	protein inhibitor of activated STAT 3	Homo sapiens	45-51
20235152-0	2010	Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells.	Curcumin	0-8	protein inhibitor of activated STAT 3	Homo sapiens	110-116
20235152-11	2010	Of significance, siRNA-mediated knockdown of PIAS-3 overcomes the inhibitory effect of curcumin on STAT-3 phosphorylation and cell viability.	Curcumin	87-95	signal transducer and activator of transcription 3	Homo sapiens	99-105
20235152-12	2010	In conclusion, curcumin suppresses JAK-STAT signaling via activation of PIAS-3, thus attenuating STAT-3 phosphorylation and tumor cell growth.	Curcumin	15-23	protein inhibitor of activated STAT 3	Homo sapiens	72-78
20235152-5	2010	Treatment of cancer cells with curcumin induced a dose- and time-dependent decrease of constitutive IL-6 expression and of constitutive and IL-6-induced STAT-3 phosphorylation, which is associated with decreased cell viability and increased cleavage of caspase-3.	Curcumin	31-39	interleukin 6	Homo sapiens	100-104
20235152-12	2010	In conclusion, curcumin suppresses JAK-STAT signaling via activation of PIAS-3, thus attenuating STAT-3 phosphorylation and tumor cell growth.	Curcumin	15-23	signal transducer and activator of transcription 3	Homo sapiens	97-103
20235152-5	2010	Treatment of cancer cells with curcumin induced a dose- and time-dependent decrease of constitutive IL-6 expression and of constitutive and IL-6-induced STAT-3 phosphorylation, which is associated with decreased cell viability and increased cleavage of caspase-3.	Curcumin	31-39	interleukin 6	Homo sapiens	140-144
20235152-5	2010	Treatment of cancer cells with curcumin induced a dose- and time-dependent decrease of constitutive IL-6 expression and of constitutive and IL-6-induced STAT-3 phosphorylation, which is associated with decreased cell viability and increased cleavage of caspase-3.	Curcumin	31-39	signal transducer and activator of transcription 3	Homo sapiens	153-159
20235152-5	2010	Treatment of cancer cells with curcumin induced a dose- and time-dependent decrease of constitutive IL-6 expression and of constitutive and IL-6-induced STAT-3 phosphorylation, which is associated with decreased cell viability and increased cleavage of caspase-3.	Curcumin	31-39	caspase 3	Homo sapiens	253-262
20235152-6	2010	The inhibition of STAT-3 activation by curcumin was reversible, and phosphorylated STAT-3 levels returned to control levels 24 h after curcumin removal.	Curcumin	39-47	signal transducer and activator of transcription 3	Homo sapiens	18-24
20235152-6	2010	The inhibition of STAT-3 activation by curcumin was reversible, and phosphorylated STAT-3 levels returned to control levels 24 h after curcumin removal.	Curcumin	135-143	signal transducer and activator of transcription 3	Homo sapiens	18-24
20235152-6	2010	The inhibition of STAT-3 activation by curcumin was reversible, and phosphorylated STAT-3 levels returned to control levels 24 h after curcumin removal.	Curcumin	135-143	signal transducer and activator of transcription 3	Homo sapiens	83-89
20181392-0	2010	Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer"s disease.	Curcumin	50-58	amyloid beta precursor protein	Homo sapiens	81-86
20127174-0	2010	Curcumin sensitizes non-small cell lung cancer cell anoikis through reactive oxygen species-mediated Bcl-2 downregulation.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	101-106
20127174-6	2010	Curcumin downregulated Bcl-2 protein during anoikis and sensitized the cells to detachment-induced apoptosis, whereas it had no significant effect on Cav-1 protein expression.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	23-28
20127174-7	2010	Bcl-2 down-regulation as well as anoikis enhancement by curcumin were inhibited by superoxide anion scavenger, Mn(III)tetrakis(4-benzoic acid) porphyrin chloride, but were unaffected by other ROS scavengers including catalase and deferoxamine, suggesting that superoxide anion is a key player in the downregulation of Bcl-2 by curcumin.	Curcumin	56-64	BCL2 apoptosis regulator	Homo sapiens	318-323
20127174-7	2010	Bcl-2 down-regulation as well as anoikis enhancement by curcumin were inhibited by superoxide anion scavenger, Mn(III)tetrakis(4-benzoic acid) porphyrin chloride, but were unaffected by other ROS scavengers including catalase and deferoxamine, suggesting that superoxide anion is a key player in the downregulation of Bcl-2 by curcumin.	Curcumin	327-335	BCL2 apoptosis regulator	Homo sapiens	0-5
20127174-8	2010	Furthermore, we provided evidence that curcumin decreased Bcl-2 level through ubiquitin-proteasomal degradation which sensitized cells to detachment-induced apoptosis.	Curcumin	39-47	BCL2 apoptosis regulator	Homo sapiens	58-63
20127174-9	2010	These findings indicate a novel pathway for curcumin regulation of Bcl-2 and provide a key mechanism of anoikis regulation that may be exploited for metastatic cancer treatment.	Curcumin	44-52	BCL2 apoptosis regulator	Homo sapiens	67-72
20112103-14	2010	Curcumin showed a significant hepatoprotective activity by lowering the levels of serum marker enzymes, lipid peroxidation and elevating the levels of GSH, SOD, CAT and GSH-Px.	Curcumin	0-8	catalase	Rattus norvegicus	161-164
20181392-1	2010	Curcumin, which can exist in an equilibrium between keto and enol tautomers, binds to beta-amyloid (Abeta) fibrils/aggregates.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	100-105
20181392-2	2010	The aim of this study was to assess the relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities.	Curcumin	90-98	amyloid beta precursor protein	Homo sapiens	121-126
20181392-3	2010	Curcumin derivatives with keto-enol tautomerism showed high levels of binding to Abeta aggregates but not to Abeta monomers.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	81-86
20181392-4	2010	The binding activity of the keto form analogue of curcumin to Abeta aggregates was found to be much weaker than that of curcumin derivatives with keto-enol tautomerism.	Curcumin	50-58	amyloid beta precursor protein	Homo sapiens	62-67
20181392-5	2010	The color of a curcumin derivative with keto-enol tautomerism, which was substituted at the C-4 position, changed from yellow to orange within 30 min of being combined with Abeta aggregates in physiological buffer.	Curcumin	15-23	amyloid beta precursor protein	Homo sapiens	173-178
20181392-7	2010	These findings suggest that curcumin derivatives exist predominantly in the enol form during binding to Abeta aggregates, and that the enolization of curcumin derivatives is crucial for binding to Abeta aggregates.	Curcumin	28-36	amyloid beta precursor protein	Homo sapiens	104-109
19513843-0	2010	Oral administration of curcumin emulsified in carboxymethyl cellulose has a potent anti-inflammatory effect in the IL-10 gene-deficient mouse model of IBD.	Curcumin	23-31	interleukin 10	Mus musculus	115-120
20181392-7	2010	These findings suggest that curcumin derivatives exist predominantly in the enol form during binding to Abeta aggregates, and that the enolization of curcumin derivatives is crucial for binding to Abeta aggregates.	Curcumin	150-158	amyloid beta precursor protein	Homo sapiens	197-202
20388782-4	2010	Mechanistic investigations revealed a significant reduction in cell viability in CDF-treated cells compared with curcumin-treated cells, which were also associated with the induction of apoptosis, and these results were consistent with the downregulation of Akt, cyclooxygenase-2, prostaglandin E(2), vascular endothelial growth factor, and NF-kappaB DNA binding activity.	Curcumin	113-121	AKT serine/threonine kinase 1	Homo sapiens	258-261
19513843-6	2010	Our data demonstrate that in IL-10 gene-deficient mice, both oral curcumin and carboxymethyl cellulose, appear to have modifying effects on colitis.	Curcumin	66-74	interleukin 10	Mus musculus	29-34
20188213-0	2010	Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	45-53
20222050-5	2010	Moreover, curcumin increased phosphorylation of hepatic janus-activated kinase-signal transducer 2 and subsequently also stimulated Akt and ERK1/2 activation in this model.	Curcumin	10-18	AKT serine/threonine kinase 1	Rattus norvegicus	132-135
20222050-9	2010	Additionally, curcumin was found to significantly reduce hepatic PTP1B expression and activity in this model.	Curcumin	14-22	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	65-70
20222050-10	2010	CONCLUSION: Our data indicate that the mechanisms by which curcumin protects against fructose-induced hypertriglyceridemia and hepatic steatosis are its inhibition on PTP1B and subsequently improvement of insulin and leptin sensitivity in the liver of rats.	Curcumin	59-67	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	167-172
20222050-11	2010	This PTP1B inhibitory property may be a promising therapeutic strategy for curcumin to treat fructose-induced hepatic steatosis driven by hepatic insulin and leptin resistance.	Curcumin	75-83	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	5-10
20188213-8	2010	The results showed that compared with untreated CIA mice, curcumin-treated mice downregulated clinical arthritis score, the proliferation of splenic T cells, expression levels of TNF-alpha and IL-1beta in the ankle joint, and expression levels of IgG2a in serum.	Curcumin	58-66	tumor necrosis factor	Mus musculus	179-188
20188213-8	2010	The results showed that compared with untreated CIA mice, curcumin-treated mice downregulated clinical arthritis score, the proliferation of splenic T cells, expression levels of TNF-alpha and IL-1beta in the ankle joint, and expression levels of IgG2a in serum.	Curcumin	58-66	interleukin 1 beta	Mus musculus	193-201
20188213-9	2010	Additionally, by altering nuclear factor (NF)-kappaB transcription activity in FLSs, curcumin inhibited PGE(2) production, COX-2 expression, and MMP secretion.	Curcumin	85-93	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	26-52
20188213-9	2010	Additionally, by altering nuclear factor (NF)-kappaB transcription activity in FLSs, curcumin inhibited PGE(2) production, COX-2 expression, and MMP secretion.	Curcumin	85-93	prostaglandin-endoperoxide synthase 2	Homo sapiens	123-128
20411591-10	2010	Treatment of bradykinin with AP-1 inhibitors Tanshinone IIA and curcumin also reduced COX-2 expression and glioma cell migration.	Curcumin	64-72	kininogen 1	Homo sapiens	13-23
20372820-4	2010	In addition, oral administration of monoacetylcurcumin to mice led to greater suppression of TNF-alpha production after LPS stimulation than the administration of curcumin or tetrahydrocurcumin in vivo.	Curcumin	46-54	tumor necrosis factor	Mus musculus	93-102
20169331-9	2010	STAT3 inhibitors, including curcumin, AG490 and a peptide (PpYLKTK), reduced hepcidin1 mRNA expression even when cells were additionally exposed to IL-6.	Curcumin	28-36	signal transducer and activator of transcription 3	Mus musculus	0-5
20169331-9	2010	STAT3 inhibitors, including curcumin, AG490 and a peptide (PpYLKTK), reduced hepcidin1 mRNA expression even when cells were additionally exposed to IL-6.	Curcumin	28-36	interleukin 6	Mus musculus	148-152
20132469-4	2010	The protective effect of curcumin was associated with a significant attenuation in the acute pericontusional expression of interleukin-1beta, a pro-inflammatory cytokine, after injury.	Curcumin	25-33	interleukin 1 beta	Mus musculus	123-140
20132469-6	2010	Notably, curcumin blocked IL-1beta-induced aquaporin-4 expression in cultured astrocytes, an effect mediated, at least in part, by reduced activation of the p50 and p65 subunits of nuclear factor kappaB.	Curcumin	9-17	interleukin 1 beta	Mus musculus	26-34
20132469-6	2010	Notably, curcumin blocked IL-1beta-induced aquaporin-4 expression in cultured astrocytes, an effect mediated, at least in part, by reduced activation of the p50 and p65 subunits of nuclear factor kappaB.	Curcumin	9-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-160
20407012-4	2010	BA, curcumin, and iSp also decreased phosphorylation of Akt in these cells, and downregulation of EGFR by BA, curcumin, and iSp was accompanied by induction of LC3 and autophagy, which is consistent with recent studies showing that EGFR suppresses autophagic cell death.	Curcumin	4-12	epidermal growth factor receptor	Homo sapiens	232-236
20407012-4	2010	BA, curcumin, and iSp also decreased phosphorylation of Akt in these cells, and downregulation of EGFR by BA, curcumin, and iSp was accompanied by induction of LC3 and autophagy, which is consistent with recent studies showing that EGFR suppresses autophagic cell death.	Curcumin	110-118	epidermal growth factor receptor	Homo sapiens	98-102
20407012-4	2010	BA, curcumin, and iSp also decreased phosphorylation of Akt in these cells, and downregulation of EGFR by BA, curcumin, and iSp was accompanied by induction of LC3 and autophagy, which is consistent with recent studies showing that EGFR suppresses autophagic cell death.	Curcumin	110-118	epidermal growth factor receptor	Homo sapiens	232-236
20407012-5	2010	The results show that EGFR is an Sp-regulated gene in bladder cancer, and drugs such as BA and curcumin that repress Sp proteins also ablate EGFR expression.	Curcumin	95-103	epidermal growth factor receptor	Homo sapiens	22-26
20407012-5	2010	The results show that EGFR is an Sp-regulated gene in bladder cancer, and drugs such as BA and curcumin that repress Sp proteins also ablate EGFR expression.	Curcumin	95-103	epidermal growth factor receptor	Homo sapiens	141-145
20407012-6	2010	Thus, compounds such as curcumin and BA that downregulate Sp transcription factors represent a novel class of anticancer drugs that target EGFR in bladder cancer cells and tumors by inhibiting receptor expression.	Curcumin	24-32	epidermal growth factor receptor	Homo sapiens	139-143
20405005-10	2010	The curcumin-induced growth inhibition was accompanied by decreased NFkappaB activity.	Curcumin	4-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	68-76
20346917-0	2010	Curcumin dramatically enhances retinoic acid-induced superoxide generating activity via accumulation of p47-phox and p67-phox proteins in U937 cells.	Curcumin	0-8	CD33 molecule	Homo sapiens	117-120
20508869-6	2010	Oral supplementation of curcumin at a dose of 2 g/kg for 30 days resulted in a transient decrease in MDA, catalase and GST levels in the rat cerebrum and cerebellum.	Curcumin	24-32	catalase	Rattus norvegicus	106-114
20426658-8	2010	In vitro, curcumin boosted antioxidant defenses by increasing heme oxygenase 1 (HO-1) levels in primary lung endothelial and fibroblast cells and blocked radiation-induced generation of reactive oxygen species (ROS).	Curcumin	10-18	heme oxygenase 1	Mus musculus	62-78
20426658-8	2010	In vitro, curcumin boosted antioxidant defenses by increasing heme oxygenase 1 (HO-1) levels in primary lung endothelial and fibroblast cells and blocked radiation-induced generation of reactive oxygen species (ROS).	Curcumin	10-18	heme oxygenase 1	Mus musculus	80-84
20426658-9	2010	Dietary curcumin significantly increased HO-1 in lungs as early as after 1 week of feeding, coinciding with a steady-state level of curcumin in plasma.	Curcumin	8-16	heme oxygenase 1	Mus musculus	41-45
20426658-10	2010	Although both 1% and 5% w/w dietary curcumin exerted physiological changes in lung tissues by significantly decreasing LPS-induced TNF-alpha production in lungs, only 5% dietary curcumin significantly improved survival of mice after irradiation and decreased radiation-induced lung fibrosis.	Curcumin	36-44	tumor necrosis factor	Mus musculus	131-140
20429876-11	2010	During the 6 hr pre-treatment, curcumin down regulated the expression of Bcl-XL and Mcl-1 pro-survival proteins.	Curcumin	31-39	BCL2 like 1	Homo sapiens	73-79
20429876-12	2010	Curcumin pre-treatment followed by exposure to low doses of cisplatin increased apoptosis as indicated by annexin V staining and cleavage of caspase 9 and PARP.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	155-159
20346917-6	2010	On the other hand, immunoblot analysis revealed that co-treatment with RA and curcumin caused remarkable accumulation of protein levels of p47-phox (to 7-fold) and p67-phox (to 4-fold) compared with those of the RA-treatment alone.	Curcumin	78-86	CD33 molecule	Homo sapiens	164-167
20346917-7	2010	These results suggested that curcumin dramatically enhances RA-induced O(2)(-)-generating activity via accumulation of cytosolic p47-phox and p67-phox proteins in U937 cells.	Curcumin	29-37	CD33 molecule	Homo sapiens	142-145
21160593-4	2010	At this time, it appears that curcumin"s anti-carcinogenic properties are most likely due to its effects on multiple molecular targets, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and activator protein 1 (AP-1).	Curcumin	30-38	nuclear factor kappa B subunit 1	Homo sapiens	208-217
21160593-4	2010	At this time, it appears that curcumin"s anti-carcinogenic properties are most likely due to its effects on multiple molecular targets, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and activator protein 1 (AP-1).	Curcumin	30-38	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	223-242
21160593-4	2010	At this time, it appears that curcumin"s anti-carcinogenic properties are most likely due to its effects on multiple molecular targets, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and activator protein 1 (AP-1).	Curcumin	30-38	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	244-248
21160593-6	2010	Curcumin has also been shown to affect a variety of other key players involved in carcinogenesis, such as cyclooxygenase-2, matrix metallopeptidases 2 and 9 and tumor necrosis factor alpha induced vascular cell adhesion molecule, just to name a few.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	106-188
20405005-13	2010	CONCLUSION: The ability of curcumin to inhibit NFkappaB and induce apoptosis in pituitary corticotroph tumor cells leads us to propose developing it as a novel therapeutic agent for the treatment of CD.	Curcumin	27-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	47-55
20138829-0	2010	Modulation of curcumin-induced Akt phosphorylation and apoptosis by PI3K inhibitor in MCF-7 cells.	Curcumin	14-22	AKT serine/threonine kinase 1	Homo sapiens	31-34
20360934-6	2010	Curcumin alone inhibited NF-kappaB activity and induced apoptosis in both Flo-1 and OE33 EAC cell lines as determined by Western blot analysis, NF-kappaB reporter assays, and Caspase-Glo 3/7 assays.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	25-34
20138829-2	2010	One mechanism of curcumin-induced apoptosis is through the PI3K/Akt signaling pathway.	Curcumin	17-25	AKT serine/threonine kinase 1	Homo sapiens	64-67
20138829-5	2010	In this study we found that curcumin induces apoptotic cell death in MCF-7 cells, as assessed by MTT assay, DNA ladder formation, PARP cleavage, p53 and Bax induction.	Curcumin	28-36	tumor protein p53	Homo sapiens	145-148
20138829-5	2010	In this study we found that curcumin induces apoptotic cell death in MCF-7 cells, as assessed by MTT assay, DNA ladder formation, PARP cleavage, p53 and Bax induction.	Curcumin	28-36	BCL2 associated X, apoptosis regulator	Homo sapiens	153-156
20138829-6	2010	At apoptotic inducing concentration, curcumin induces a dramatic Akt phosphorylation, accompanied by an increased phosphorylation of glycogen synthase kinase 3beta (GSK3beta), which has been considered to be a pro-growth signaling molecule.	Curcumin	37-45	AKT serine/threonine kinase 1	Homo sapiens	65-68
20138829-8	2010	The inhibitor LY290042 was capable of attenuating curcumin-induced Akt phosphorylation and activation of GSK3beta.	Curcumin	50-58	AKT serine/threonine kinase 1	Homo sapiens	67-70
20138829-9	2010	All together, our data suggest that blocking the PI3K/Akt survival pathway sensitizes the curcumin-induced apoptosis in MCF-7 cells.	Curcumin	90-98	AKT serine/threonine kinase 1	Homo sapiens	54-57
20338767-3	2010	In this study, we synthesized and examined a series of 5-carbon linker-containing mono-carbonyl analogues of curcumin with potent inhibitory activities against TNF-alpha and IL-6 release in LPS-stimulated RAW 264.7 macrophages.	Curcumin	109-117	tumor necrosis factor	Homo sapiens	160-169
20338767-3	2010	In this study, we synthesized and examined a series of 5-carbon linker-containing mono-carbonyl analogues of curcumin with potent inhibitory activities against TNF-alpha and IL-6 release in LPS-stimulated RAW 264.7 macrophages.	Curcumin	109-117	interleukin 6	Homo sapiens	174-178
20373902-7	2010	Curcumin significantly increased the level of cytosol cytochrome c (2-fold greater than the controls after 2 hr treatment), caspase-9 and caspase-3 activities (approximately 4.5- and 6-fold greater than the controls after 2-6 hr treatment, respectively) in a dose-dependent manner.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	54-66
20373902-7	2010	Curcumin significantly increased the level of cytosol cytochrome c (2-fold greater than the controls after 2 hr treatment), caspase-9 and caspase-3 activities (approximately 4.5- and 6-fold greater than the controls after 2-6 hr treatment, respectively) in a dose-dependent manner.	Curcumin	0-8	caspase 3	Homo sapiens	138-147
20373902-9	2010	This effect is associated with the release of cytochrome c from the mitochondria and the activation of caspase-9 and caspase-3 in uveal melanoma cells after treatment with curcumin.	Curcumin	172-180	cytochrome c, somatic	Homo sapiens	46-58
20373902-9	2010	This effect is associated with the release of cytochrome c from the mitochondria and the activation of caspase-9 and caspase-3 in uveal melanoma cells after treatment with curcumin.	Curcumin	172-180	caspase 3	Homo sapiens	117-126
20569277-4	2010	Exposure of cells to hydrogen peroxide 24 hrs after the curcumin treatment decreased caspase-12 activation, total protein oxidation and translocation of NF-kappaB to the nucleus, compared with untreated cells.	Curcumin	56-64	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	153-162
20569277-6	2010	The delayed cytoprotection induced by curcumin acted through Grp94, because the curcumin-induced increase in Grp94 expression was hampered by either stable or transient transfection with antisense cDNA; in these latter cells, the extent of total protein oxidation, as well as the translocation of NF-kappaB to the nucleus, and the percentage of apoptotic cells were comparable to those observed in both curcumin-untreated wild-type and empty vector transfected cells.	Curcumin	38-46	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	297-306
20569277-6	2010	The delayed cytoprotection induced by curcumin acted through Grp94, because the curcumin-induced increase in Grp94 expression was hampered by either stable or transient transfection with antisense cDNA; in these latter cells, the extent of total protein oxidation, as well as the translocation of NF-kappaB to the nucleus, and the percentage of apoptotic cells were comparable to those observed in both curcumin-untreated wild-type and empty vector transfected cells.	Curcumin	80-88	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	297-306
20569277-6	2010	The delayed cytoprotection induced by curcumin acted through Grp94, because the curcumin-induced increase in Grp94 expression was hampered by either stable or transient transfection with antisense cDNA; in these latter cells, the extent of total protein oxidation, as well as the translocation of NF-kappaB to the nucleus, and the percentage of apoptotic cells were comparable to those observed in both curcumin-untreated wild-type and empty vector transfected cells.	Curcumin	80-88	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	297-306
20056776-6	2010	The animals that received curcumin alone orally or in combination with augmentin, 15 days prior to bacterial instillation into the lungs via the intranasal route, showed a significant (P &lt;0.05) decrease in neutrophil influx into the lungs and a significant (P &lt;0.05) decrease in the production of MDA, NO, MPO activity and TNF-alpha levels.	Curcumin	26-34	tumor necrosis factor	Mus musculus	329-338
19777504-0	2010	Inhibitory effect of curcumin on motility of human oral squamous carcinoma YD-10B cells via suppression of ERK and NF-kappaB activations.	Curcumin	21-29	mitogen-activated protein kinase 1	Homo sapiens	107-110
19777504-2	2010	Here, we found that curcumin inhibited cell proliferation and motility with decreased activities of matrix metalloproteinase (MMP)-2/9 and decreased mRNA expressions of urokinase-type plasminogen activator (uPA) and its receptor uPAR in the highly invasive human YD-10B OSCC cells.	Curcumin	20-28	plasminogen activator, urokinase	Homo sapiens	169-205
19777504-2	2010	Here, we found that curcumin inhibited cell proliferation and motility with decreased activities of matrix metalloproteinase (MMP)-2/9 and decreased mRNA expressions of urokinase-type plasminogen activator (uPA) and its receptor uPAR in the highly invasive human YD-10B OSCC cells.	Curcumin	20-28	plasminogen activator, urokinase	Homo sapiens	207-210
19777504-3	2010	Western blot analysis showed that curcumin inhibited the activation of MAP kinases (especially ERK) and NF-kappaB, which are involved in the transcriptional regulation of proteolytic enzymes.	Curcumin	34-42	mitogen-activated protein kinase 1	Homo sapiens	95-98
19777504-4	2010	In conclusion, curcumin is one of the strong phytochemicals with antimotility activity of OSCC; the inhibitory effect of curcumin on the motility of YD-10B cells could result from its potential to inhibit the activation of ERK/MAP kinase and NF-kappaB that consequently down-regulate the mRNA expressions and activities of proteolytic enzymes such as uPA and MMP-2/9.	Curcumin	15-23	mitogen-activated protein kinase 1	Homo sapiens	223-226
19777504-4	2010	In conclusion, curcumin is one of the strong phytochemicals with antimotility activity of OSCC; the inhibitory effect of curcumin on the motility of YD-10B cells could result from its potential to inhibit the activation of ERK/MAP kinase and NF-kappaB that consequently down-regulate the mRNA expressions and activities of proteolytic enzymes such as uPA and MMP-2/9.	Curcumin	121-129	mitogen-activated protein kinase 1	Homo sapiens	223-226
19777504-4	2010	In conclusion, curcumin is one of the strong phytochemicals with antimotility activity of OSCC; the inhibitory effect of curcumin on the motility of YD-10B cells could result from its potential to inhibit the activation of ERK/MAP kinase and NF-kappaB that consequently down-regulate the mRNA expressions and activities of proteolytic enzymes such as uPA and MMP-2/9.	Curcumin	121-129	plasminogen activator, urokinase	Homo sapiens	351-354
20416164-7	2010	The Western blot detection revealed that expressions of pro-caspase 3 and BCL-XL were down-regulated, expressions of caspase 3 and sheared PAPP were up-regulated in NB4-R1 cells treated with 20 micromol/L of Curcumin.	Curcumin	208-216	caspase 3	Homo sapiens	56-69
20416164-7	2010	The Western blot detection revealed that expressions of pro-caspase 3 and BCL-XL were down-regulated, expressions of caspase 3 and sheared PAPP were up-regulated in NB4-R1 cells treated with 20 micromol/L of Curcumin.	Curcumin	208-216	BCL2 like 1	Homo sapiens	74-80
20416164-7	2010	The Western blot detection revealed that expressions of pro-caspase 3 and BCL-XL were down-regulated, expressions of caspase 3 and sheared PAPP were up-regulated in NB4-R1 cells treated with 20 micromol/L of Curcumin.	Curcumin	208-216	caspase 3	Homo sapiens	60-69
20332524-0	2010	Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation.	Curcumin	0-8	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	44-48
20332524-5	2010	RESULTS: Liver damage, cholestasis and fibrosis were reduced in Mdr2(-/-) mice after curcumin feeding.	Curcumin	85-93	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	64-68
20332524-6	2010	Moreover, curcumin inhibited cholangiocyte proliferation and expression of activation marker vascular cell adhesion molecule-1 in Mdr2(-/-) mice.	Curcumin	10-18	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	130-134
20332524-7	2010	Curcumin-similar to PPARgamma synthetic agonist troglitazone-directly inhibited TNF-alpha-induced inflammatory activation of cholangiocytes in vitro, whereas these beneficial effects of curcumin were largely blocked by a PPARgamma synthetic antagonist.	Curcumin	0-8	tumor necrosis factor	Mus musculus	80-89
20360934-2	2010	Curcumin, an orally available naturally occurring compound, has been shown to inhibit NF-kappaB and has a potential role in cancer chemoprevention.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	86-95
20360934-6	2010	Curcumin alone inhibited NF-kappaB activity and induced apoptosis in both Flo-1 and OE33 EAC cell lines as determined by Western blot analysis, NF-kappaB reporter assays, and Caspase-Glo 3/7 assays.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	144-153
20360934-9	2010	In addition, curcumin, a well-known inhibitor of NF-kappaB activity, was shown to increase apoptosis and enhance both 5-FU- and CDDP-mediated chemosensitivity, suggesting that it may have potential application in the therapy of patients with EAC.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	49-58
20430162-12	2010	Pretreatment with curcumin significantly attenuated the inflammatory, oxidative, and nitrosative responses and lung tissue iNOS and TNFalpha expressions.	Curcumin	18-26	nitric oxide synthase 2	Rattus norvegicus	123-127
20430162-12	2010	Pretreatment with curcumin significantly attenuated the inflammatory, oxidative, and nitrosative responses and lung tissue iNOS and TNFalpha expressions.	Curcumin	18-26	tumor necrosis factor	Rattus norvegicus	132-140
20393001-5	2010	An ex vivo model of cryopreserved human hepatocytes was used to evaluate the CYP450 metabolism induction potential of curcumin for CYP P450 3A4, 2C8/2C9, and 2D6.	Curcumin	118-126	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	77-83
20215512-3	2010	We have recently developed novel small-molecule STAT3 inhibitors, known as FLLL31 and FLLL32, which are derived from curcumin (the primary bioactive compound of turmeric).	Curcumin	117-125	signal transducer and activator of transcription 3	Homo sapiens	48-53
20148537-0	2010	Resveratrol, genistein, and curcumin bind bovine serum albumin.	Curcumin	28-36	albumin	Homo sapiens	49-62
20148537-1	2010	We report the complexation of bovine serum albumin (BSA) with resveratrol, genistein, and curcumin, at physiological conditions, using constant protein concentration and various polyphenol contents.	Curcumin	90-98	albumin	Homo sapiens	37-50
20393001-7	2010	At a curcumin concentration of 58.3 microM, 10.5% and 22.5% inhibition of CYP450 2C9 and CYP450 2C8 activity, respectively, was observed.	Curcumin	5-13	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	74-80
20393001-7	2010	At a curcumin concentration of 58.3 microM, 10.5% and 22.5% inhibition of CYP450 2C9 and CYP450 2C8 activity, respectively, was observed.	Curcumin	5-13	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	89-95
19733855-5	2010	In addition, IL-8 up-regulation in response to GSA was inhibited by resveratrol, curcumin, diphenyleneiodium, U0126, and SB202190.	Curcumin	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	13-17
20393001-10	2010	CONCLUSION: There is low potential for CYP450 mediated drug interactions at physiologic serum concentrations of liposomal curcumin.	Curcumin	122-130	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	39-45
20393001-11	2010	Based on preliminary data, liposomal curcumin will not interact with other chemotherapy agents that are metabolized and/or eliminated via the primary drug metabolizing CYP450 pathways.	Curcumin	37-45	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	168-174
20036734-5	2010	ERK2 and JNK activation were positively associated with curcumin-induced cell death.	Curcumin	56-64	mitogen-activated protein kinase 1	Homo sapiens	0-4
19878610-0	2010	Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	20-23
19878610-0	2010	Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	77-85
19878610-0	2010	Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease.	Curcumin	0-8	matrix metallopeptidase 3	Homo sapiens	90-116
19878610-9	2010	Our aim was to assess the effect of curcumin on key disease mediators p38 mitogen-activated protein kinase (MAPK), IL-1beta, IL-10 and matrix metalloproteinase-3 (MMP-3) in the gut of children and adults with IBD.	Curcumin	36-44	mitogen-activated protein kinase 14	Homo sapiens	70-73
19878610-9	2010	Our aim was to assess the effect of curcumin on key disease mediators p38 mitogen-activated protein kinase (MAPK), IL-1beta, IL-10 and matrix metalloproteinase-3 (MMP-3) in the gut of children and adults with IBD.	Curcumin	36-44	matrix metallopeptidase 3	Homo sapiens	163-168
19878610-13	2010	We show reduced p38 MAPK activation in curcumin-treated mucosal biopsies, enhanced IL-10 and reduced IL-1beta.	Curcumin	39-47	mitogen-activated protein kinase 14	Homo sapiens	16-19
19878610-14	2010	We demonstrate dose-dependent suppression of MMP-3 in CMF with curcumin.	Curcumin	63-71	matrix metallopeptidase 3	Homo sapiens	45-50
20160040-5	2010	TxnRd1 knockdown cells showed decreased radiation-induced reactive oxygen species and sustained extracellular signal-regulated kinase 1/2 activation, which we previously showed was required for curcumin-mediated radiosensitization.	Curcumin	194-202	mitogen-activated protein kinase 3	Homo sapiens	96-137
20026325-0	2010	Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	50-58
20026325-11	2010	Pretreatment of curcumin (5muM) completely abolished the increased production of IL-1beta induced by the hyperosmotic medium.	Curcumin	16-24	interleukin 1 beta	Homo sapiens	81-89
20026325-12	2010	Increased phosphorylation of p38 caused by high osmolarity was also completely abolished by curcumin, whereas the phosphorylation of JNK was only partially inhibited.	Curcumin	92-100	mitogen-activated protein kinase 14	Homo sapiens	29-32
20026325-13	2010	SB 203580 (p38 inhibitor), but not SP 600125 (JNK inhibitor), completely suppressed hyperosmoticity-induced IL-1beta production, indicating that the inhibition of production of IL-1beta by curcumin may be achieved through the p38 signal pathway.	Curcumin	189-197	interleukin 1 beta	Homo sapiens	177-185
20026325-14	2010	Curcumin completely abolished a hyperosmoticity-induced increase of NF-kappaB p65.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	68-77
20036734-5	2010	ERK2 and JNK activation were positively associated with curcumin-induced cell death.	Curcumin	56-64	mitogen-activated protein kinase 8	Homo sapiens	9-12
20018257-1	2010	Our previous report has showed that demethoxycurcumin (DMC), a natural derivative of curcumin (Cur), exhibited stronger inhibitory activity on nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) production compared with Cur in lipopolysaccharide (LPS) activated rat primary microglia.	Curcumin	45-53	tumor necrosis factor	Rattus norvegicus	165-192
19788403-8	2010	On contrary, curcumin increased IFN-gamma, IL-12 and IL-13 levels, but decreased TNF-alpha level in rats.	Curcumin	13-21	interleukin 13	Rattus norvegicus	53-58
19788403-8	2010	On contrary, curcumin increased IFN-gamma, IL-12 and IL-13 levels, but decreased TNF-alpha level in rats.	Curcumin	13-21	tumor necrosis factor	Rattus norvegicus	81-90
19821784-8	2010	On the contrary, curcumin increased IFN-gamma, IL-12 and IL-13 levels, but decreased TNF-alpha level in rats.	Curcumin	17-25	interleukin 13	Rattus norvegicus	57-62
19821784-8	2010	On the contrary, curcumin increased IFN-gamma, IL-12 and IL-13 levels, but decreased TNF-alpha level in rats.	Curcumin	17-25	tumor necrosis factor	Rattus norvegicus	85-94
19806380-6	2010	Alone or in combination with TRAIL-mediated immunotherapy or radiotherapy, curcumin is also reported to be a good inducer of prostate cancer cell death by apoptosis.	Curcumin	75-83	TNF superfamily member 10	Homo sapiens	29-34
20018257-1	2010	Our previous report has showed that demethoxycurcumin (DMC), a natural derivative of curcumin (Cur), exhibited stronger inhibitory activity on nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) production compared with Cur in lipopolysaccharide (LPS) activated rat primary microglia.	Curcumin	45-53	tumor necrosis factor	Rattus norvegicus	194-203
20025076-5	2010	Moreover, curcumin inhibited the Shh-Gli1 signaling pathway by downregulating the Shh protein and its most important downstream targets GLI1 and PTCH1.	Curcumin	10-18	patched 1	Homo sapiens	145-150
19321178-10	2010	RESULTS: After simultaneous PH+CLP curcumin significantly reduced the expression of TNF-alpha and IL-6 mRNA in the liver tissue.	Curcumin	35-43	tumor necrosis factor	Rattus norvegicus	84-93
19321178-10	2010	RESULTS: After simultaneous PH+CLP curcumin significantly reduced the expression of TNF-alpha and IL-6 mRNA in the liver tissue.	Curcumin	35-43	interleukin 6	Rattus norvegicus	98-102
19321178-11	2010	The IL-1beta concentration in the liver was also slightly, but not significantly, lower in the curcumin group.	Curcumin	95-103	interleukin 1 beta	Rattus norvegicus	4-12
20025076-6	2010	Furthermore, curcumin reduced the levels of beta-catenin, the activate/phosphorylated form of Akt and NF-kappaB, which led to downregulating the three common key effectors, namely C-myc, N-myc, and Cyclin D1.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	94-97
20025076-6	2010	Furthermore, curcumin reduced the levels of beta-catenin, the activate/phosphorylated form of Akt and NF-kappaB, which led to downregulating the three common key effectors, namely C-myc, N-myc, and Cyclin D1.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	102-111
20025076-7	2010	Consequently, apoptosis was triggered by curcumin through the mitochondrial pathway via downregulation of Bcl-2, a downstream anti-apoptotic effector of the Shh signaling.	Curcumin	41-49	BCL2 apoptosis regulator	Homo sapiens	106-111
19774461-8	2010	Curcumin treatment decreased malondialdehyde levels, cytochrome c, and cleaved caspase 3 expression and increased mitochondrial Bcl-2 expression.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	128-133
22966296-7	2010	Notably, curcumin induced an increased expression of IL-8 and IL-1beta in the HaCaT cells, but not that of IL-6 and TNF-alpha.	Curcumin	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
20127004-7	2010	Results from Western blotting showed that curcumin inhibited the protein levels of PKC, FAK, NF-kappaB p65 and Rho A leading to the inhibition of ERK1/2, MKK7, COX-2 and ROCK1, respectively, finally causing the inhibition of MMP-2 and -9 for the inhibition of migration and invasion of N18 cells.	Curcumin	42-50	synaptotagmin 1	Rattus norvegicus	103-106
22966296-7	2010	Notably, curcumin induced an increased expression of IL-8 and IL-1beta in the HaCaT cells, but not that of IL-6 and TNF-alpha.	Curcumin	9-17	interleukin 1 beta	Homo sapiens	62-70
22966296-8	2010	On the other hand, curcumin attenuated the expression of IL-6 and IL-8 in the TNF-alpha-treated HaCaT cells.	Curcumin	19-27	interleukin 6	Homo sapiens	57-61
22966296-8	2010	On the other hand, curcumin attenuated the expression of IL-6 and IL-8 in the TNF-alpha-treated HaCaT cells.	Curcumin	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
22966296-8	2010	On the other hand, curcumin attenuated the expression of IL-6 and IL-8 in the TNF-alpha-treated HaCaT cells.	Curcumin	19-27	tumor necrosis factor	Homo sapiens	78-87
19944674-7	2010	Curcumin inhibited cell growth, induced apoptosis and upregulated maspin gene expression in MCF-7 cells and these findings were further correlated with the upregulation of p53 protein and downregulation of Bcl-2, suggesting maspin mediated apoptosis in MCF-7 cells.	Curcumin	0-8	tumor protein p53	Homo sapiens	172-175
20380795-9	2010	In decoction groups, levels of collagen type I, collagen type III, TGFbeta1 and PDGF-BB were decreased, especially in the low-dose curcumin group.	Curcumin	131-139	transforming growth factor, beta 1	Rattus norvegicus	67-75
19944674-7	2010	Curcumin inhibited cell growth, induced apoptosis and upregulated maspin gene expression in MCF-7 cells and these findings were further correlated with the upregulation of p53 protein and downregulation of Bcl-2, suggesting maspin mediated apoptosis in MCF-7 cells.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	206-211
20332461-4	2010	Curcumin, a natural food additive, has a potent anti-proliferative effect, presumably mediated through NF-kappaB suppression.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	103-112
19941874-11	2010	Cytokine release was inhibited by PD98059 and curcumin, suggesting that ERK and NF-kappaB play a role in this process.	Curcumin	46-54	mitogen-activated protein kinase 1	Mus musculus	72-75
20332461-8	2010	Furthermore, curcumin down-regulated bcl-2 and bcl(x)l, leading to caspase-mediated cell death.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	37-42
20332461-8	2010	Furthermore, curcumin down-regulated bcl-2 and bcl(x)l, leading to caspase-mediated cell death.	Curcumin	13-21	BCL2 like 1	Homo sapiens	47-54
20332435-5	2010	However, inclusion of curcumin to continued FOLFOX treatment for another 48 h greatly reduced the survival of these cells, accompanied by a concomitant reduction in activation of EGFR, HER-2, IGF-1R and AKT, as well as expression of COX-2 and cyclin-D1.	Curcumin	22-30	epidermal growth factor receptor	Homo sapiens	179-183
19856147-7	2010	Hepatic necrosis and lethality caused by LPS/GalN was also greatly reduced by curcumin treatment.	Curcumin	78-86	galanin and GMAP prepropeptide	Mus musculus	45-49
20332435-5	2010	However, inclusion of curcumin to continued FOLFOX treatment for another 48 h greatly reduced the survival of these cells, accompanied by a concomitant reduction in activation of EGFR, HER-2, IGF-1R and AKT, as well as expression of COX-2 and cyclin-D1.	Curcumin	22-30	erb-b2 receptor tyrosine kinase 2	Homo sapiens	185-190
20121547-0	2010	Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and downregulation of survivin/BIRC5 gene expression.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	31-36
20332435-5	2010	However, inclusion of curcumin to continued FOLFOX treatment for another 48 h greatly reduced the survival of these cells, accompanied by a concomitant reduction in activation of EGFR, HER-2, IGF-1R and AKT, as well as expression of COX-2 and cyclin-D1.	Curcumin	22-30	AKT serine/threonine kinase 1	Homo sapiens	203-206
19647363-0	2010	Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin.	Curcumin	106-114	signal transducer and activator of transcription 3	Homo sapiens	30-35
19647363-7	2010	Treatment of the cells with curcumin inhibited LPA-induced IL-6 and IL-8 secretion and STAT3 phosphorylation, leading to blocked ovarian cancer cell motility.	Curcumin	28-36	interleukin 6	Homo sapiens	59-63
19647363-7	2010	Treatment of the cells with curcumin inhibited LPA-induced IL-6 and IL-8 secretion and STAT3 phosphorylation, leading to blocked ovarian cancer cell motility.	Curcumin	28-36	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
19647363-7	2010	Treatment of the cells with curcumin inhibited LPA-induced IL-6 and IL-8 secretion and STAT3 phosphorylation, leading to blocked ovarian cancer cell motility.	Curcumin	28-36	signal transducer and activator of transcription 3	Homo sapiens	87-92
19647363-8	2010	Collectively, the present study shows the critical role of STAT3 in ovarian cancer cell motility and that this process can be prevented by curcumin.	Curcumin	139-147	signal transducer and activator of transcription 3	Homo sapiens	59-64
19856147-8	2010	The results demonstrated that curcumin could protect mice from LPS/GalN-induced hepatic injury and inflammation through blockading TNF-alpha production, eventually raising the survival rate of septic-shock-induced mice.	Curcumin	30-38	galanin and GMAP prepropeptide	Mus musculus	67-71
19856147-8	2010	The results demonstrated that curcumin could protect mice from LPS/GalN-induced hepatic injury and inflammation through blockading TNF-alpha production, eventually raising the survival rate of septic-shock-induced mice.	Curcumin	30-38	tumor necrosis factor	Mus musculus	131-140
21086748-7	2010	Our results thus demonstrated the protective role of curcumin and ferulic acid on DMBA-induced abnormal expression of p53 and bcl-2 proteins in the buccal mucosa of golden Syrian hamsters.	Curcumin	53-61	apoptosis regulator Bcl-2	Mesocricetus auratus	126-131
19836480-4	2010	We also explore the recent literature on the molecular mechanisms of curcumin mediated alterations in gene expression mediated via activator protein 1 (AP-1)/nuclear factor-kappa B (NF-kappaB) signalling in chondrocytes, osteoblasts and synovial fibroblasts.	Curcumin	69-77	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	131-150
19616123-10	2010	The half-maximal inhibitory concentrations for free curcumin and encapsulated curcumin were found to be 13.28 and 14.34 muM, respectively.	Curcumin	52-60	latexin	Homo sapiens	120-123
19616123-10	2010	The half-maximal inhibitory concentrations for free curcumin and encapsulated curcumin were found to be 13.28 and 14.34 muM, respectively.	Curcumin	78-86	latexin	Homo sapiens	120-123
21086748-0	2010	Effect of curcumin and ferulic acid on modulation of expression pattern of p53 and bcl-2 proteins in 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.	Curcumin	10-18	apoptosis regulator Bcl-2	Mesocricetus auratus	83-88
21086748-1	2010	The modulating effect of curcumin and ferulic acid was investigated on expression pattern of apoptosis regulatory p53 and bcl-2 proteins in oral squamous cell carcinoma (OSCC).	Curcumin	25-33	apoptosis regulator Bcl-2	Mesocricetus auratus	122-127
21086748-6	2010	Oral administration of curcumin (80 mg/kg body wt) and ferulic acid (40 mg/kg body wt) to DMBA painted hamsters on days alternate to DMBA painting for 14 weeks completely inhibited tumor formation and down-regulated the expression pattern of p53 and bcl-2 proteins.	Curcumin	23-31	apoptosis regulator Bcl-2	Mesocricetus auratus	250-255
19447587-4	2010	METHODS AND RESULTS: The Matrigel migration assay showed that curcumin (10 and 20 micromol/l) effectively inhibited TNF-alpha-induced migration of HASMCs as compared with the control group.	Curcumin	62-70	tumor necrosis factor	Homo sapiens	116-125
19447587-7	2010	Furthermore, the production of ROS and the nuclear translocation of NF-kappaB p50 and p65 induced by TNF-alpha were dose-dependently suppressed by curcumin pretreatment.	Curcumin	147-155	nuclear factor kappa B subunit 1	Homo sapiens	68-81
19447587-7	2010	Furthermore, the production of ROS and the nuclear translocation of NF-kappaB p50 and p65 induced by TNF-alpha were dose-dependently suppressed by curcumin pretreatment.	Curcumin	147-155	tumor necrosis factor	Homo sapiens	101-110
19836480-4	2010	We also explore the recent literature on the molecular mechanisms of curcumin mediated alterations in gene expression mediated via activator protein 1 (AP-1)/nuclear factor-kappa B (NF-kappaB) signalling in chondrocytes, osteoblasts and synovial fibroblasts.	Curcumin	69-77	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	152-156
19836480-4	2010	We also explore the recent literature on the molecular mechanisms of curcumin mediated alterations in gene expression mediated via activator protein 1 (AP-1)/nuclear factor-kappa B (NF-kappaB) signalling in chondrocytes, osteoblasts and synovial fibroblasts.	Curcumin	69-77	nuclear factor kappa B subunit 1	Homo sapiens	182-191
19836480-6	2010	RESULTS: Recent work has shown that curcumin protects human chondrocytes from the catabolic actions of interleukin-1 beta (IL-1beta) including matrix metalloproteinase (MMP)-3 up-regulation, inhibition of collagen type II and down-regulation of beta1-integrin expression.	Curcumin	36-44	interleukin 1 beta	Homo sapiens	103-121
19836480-6	2010	RESULTS: Recent work has shown that curcumin protects human chondrocytes from the catabolic actions of interleukin-1 beta (IL-1beta) including matrix metalloproteinase (MMP)-3 up-regulation, inhibition of collagen type II and down-regulation of beta1-integrin expression.	Curcumin	36-44	interleukin 1 beta	Homo sapiens	123-131
19836480-6	2010	RESULTS: Recent work has shown that curcumin protects human chondrocytes from the catabolic actions of interleukin-1 beta (IL-1beta) including matrix metalloproteinase (MMP)-3 up-regulation, inhibition of collagen type II and down-regulation of beta1-integrin expression.	Curcumin	36-44	matrix metallopeptidase 3	Homo sapiens	143-175
19836480-7	2010	Curcumin blocks IL-1beta-induced proteoglycan degradation, AP-1/NF-kappaB signalling, chondrocyte apoptosis and activation of caspase-3.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	16-24
19836480-7	2010	Curcumin blocks IL-1beta-induced proteoglycan degradation, AP-1/NF-kappaB signalling, chondrocyte apoptosis and activation of caspase-3.	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	59-63
19836480-7	2010	Curcumin blocks IL-1beta-induced proteoglycan degradation, AP-1/NF-kappaB signalling, chondrocyte apoptosis and activation of caspase-3.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	64-73
19836480-7	2010	Curcumin blocks IL-1beta-induced proteoglycan degradation, AP-1/NF-kappaB signalling, chondrocyte apoptosis and activation of caspase-3.	Curcumin	0-8	caspase 3	Homo sapiens	126-135
20199731-9	2010	CONCLUSIONS: Curcumin has protective effects against NEC in neonatal rats, possibly through inhibiting COX-2 expression, reducing TNF-alpha content, and increasing IL-10 content.	Curcumin	13-21	tumor necrosis factor	Rattus norvegicus	130-139
20230279-3	2010	In this study, we investigated whether curcumin protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP) or 1-methyl-4-phenylpyridnium ion- (MPP(+)) induced dopaminergic neurotoxicity in C57BL/6N mice or SH-SY5Y cells by inhibiting JNK pathways both in vivo and in vitro.	Curcumin	39-47	mitogen-activated protein kinase 8	Homo sapiens	245-248
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	Curcumin	81-89	interleukin 1 alpha	Rattus norvegicus	20-29
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	Curcumin	81-89	interleukin 1 beta	Rattus norvegicus	31-39
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	Curcumin	81-89	interleukin 6	Rattus norvegicus	44-48
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	Curcumin	81-89	interleukin 6	Rattus norvegicus	243-247
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	Curcumin	81-89	interleukin 1 alpha	Rattus norvegicus	260-269
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	Curcumin	81-89	interleukin 1 beta	Rattus norvegicus	274-282
19914224-10	2010	Interestingly decreased activities of cytosolic CAT and GPx1 were alleviated following vitamin E and curcumin administration.	Curcumin	101-109	glutathione peroxidase 1	Rattus norvegicus	56-60
20450049-5	2010	The effect of curcumin on the expression of anti-apoptosis genes (Survivin and BCl-xL) and drug resistance genes (DRG2 and MDR1) was studied by reverse transcription-polymerase chain reaction (RT-PCR).	Curcumin	14-22	BCL2 like 1	Homo sapiens	79-85
20450049-5	2010	The effect of curcumin on the expression of anti-apoptosis genes (Survivin and BCl-xL) and drug resistance genes (DRG2 and MDR1) was studied by reverse transcription-polymerase chain reaction (RT-PCR).	Curcumin	14-22	ATP binding cassette subfamily B member 1	Homo sapiens	123-127
20450049-6	2010	The expression of MDR1 mRNA was significantly decreased in Sk-hep-1 cells treated with curcumin, while no alterations in the amount of DRG2 and anti-apoptosis genes" mRNA levels were found.	Curcumin	87-95	ATP binding cassette subfamily B member 1	Homo sapiens	18-22
20450049-7	2010	These results indicate that curcumin is able to inhibit proliferation and induce apoptosis in Sk-hep-1 cells and it may cause by down-regulating the expression of MDR1 mRNA.	Curcumin	28-36	ATP binding cassette subfamily B member 1	Homo sapiens	163-167
19914224-5	2010	Alleviated message levels of SOD and CAT were noticed following simultaneous administration of curcumin and vitamin E to hyperthyroid rats.	Curcumin	95-103	superoxide dismutase 1	Rattus norvegicus	29-32
19914224-5	2010	Alleviated message levels of SOD and CAT were noticed following simultaneous administration of curcumin and vitamin E to hyperthyroid rats.	Curcumin	95-103	catalase	Rattus norvegicus	37-40
20062810-6	2010	We have also shown that this functional deficit can be reversed through use of curcumin, an inhibitor of Abeta oligomerization, using both analysis methods.	Curcumin	79-87	amyloid beta precursor protein	Homo sapiens	105-110
19914224-6	2010	Moreover vitamin E or curcumin treatment ameliorated GPx1 and GR mRNA levels.	Curcumin	22-30	glutathione peroxidase 1	Rattus norvegicus	53-57
19914224-8	2010	Vitamin E administration was able to alleviate SOD1, CAT and GR translated products while only CAT protein was restored to normal level by curcumin.	Curcumin	139-147	catalase	Rattus norvegicus	95-98
19914224-10	2010	Interestingly decreased activities of cytosolic CAT and GPx1 were alleviated following vitamin E and curcumin administration.	Curcumin	101-109	catalase	Rattus norvegicus	48-51
19913070-9	2010	Pretreatment with curcumin reversed the AN-induced effects, reducing the levels of MDA and enhancing CAT activity and increasing reduced GSH content both in the brain and liver.	Curcumin	18-26	catalase	Rattus norvegicus	101-104
19913070-11	2010	These results establish that curcumin pretreatment has a beneficial role in mitigating AN-induced oxidative stress both in the brains and livers of exposed rats and these effects are mediated independently of cytochrome P450 2E1 inhibition.	Curcumin	29-37	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	209-228
19682434-6	2010	Electrophoretic mobility shift assay revealed that curcumin also suppressed the gemcitabine-induced activation of the cell survival transcription factor NF-kappaB.	Curcumin	51-59	nuclear factor kappa B subunit 1	Homo sapiens	153-162
19682434-9	2010	Curcumin abolished the constitutive activation of NF-kappaB in the tumor tissue; induced apoptosis, and decreased cyclin D1, VEGF, COX-2, c-myc and Bcl-2 expression in the bladder cancer tissue.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	50-59
19682434-9	2010	Curcumin abolished the constitutive activation of NF-kappaB in the tumor tissue; induced apoptosis, and decreased cyclin D1, VEGF, COX-2, c-myc and Bcl-2 expression in the bladder cancer tissue.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	125-129
19682434-9	2010	Curcumin abolished the constitutive activation of NF-kappaB in the tumor tissue; induced apoptosis, and decreased cyclin D1, VEGF, COX-2, c-myc and Bcl-2 expression in the bladder cancer tissue.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136
19682434-9	2010	Curcumin abolished the constitutive activation of NF-kappaB in the tumor tissue; induced apoptosis, and decreased cyclin D1, VEGF, COX-2, c-myc and Bcl-2 expression in the bladder cancer tissue.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	148-153
19682434-10	2010	Overall our results suggest that curcumin alone exhibits significant antitumor effects against human bladder cancer and it further potentiates the effects of gemictabine, possibly through the modulation of NF-kappaB signaling pathway.	Curcumin	33-41	nuclear factor kappa B subunit 1	Homo sapiens	206-215
20160437-2	2010	Here, we investigate the role of curcumin in modulating the profibrotic action of TGF-beta in human proximal tubule cells (HK-2) and its underlying mechanisms.	Curcumin	33-41	transforming growth factor beta 1	Homo sapiens	82-90
20128048-2	2010	This study investigated the anti-inflammatory and antifibrotic actions of curcumin and saikosaponin A on CCl(4)-induced liver damage.	Curcumin	74-82	C-C motif chemokine ligand 4	Rattus norvegicus	105-111
20160437-6	2010	Curcumin suppressed not only TGF-beta(1)-induced Smad2 phosphorylation in a dose- and time-dependent manner, but also the nuclear accumulation of receptor-regulated Smads (R-Smad), Smad2 and Smad3.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	29-39
20160437-8	2010	CONCLUSIONS: Curcumin blocks the profibrotic actions of TGF-beta on HK-2 cells through the down-regulation of the Smad signaling pathway, and curcumin may have some similar effect as serine/threonine protein phosphatases.	Curcumin	13-21	transforming growth factor beta 1	Homo sapiens	56-64
20128048-7	2010	Therefore, supplementation with curcumin and/or saikosaponin A suppress inflammation and fibrogenesis in rats with CCl(4)-induced liver injury.	Curcumin	32-40	C-C motif chemokine ligand 4	Rattus norvegicus	115-121
20160437-4	2010	The effects of curcumin on TGF-beta(1)-regulated gene expression and Smad phosphorylation were analyzed by RT-PCR, ELISA and Western blotting.	Curcumin	15-23	transforming growth factor beta 1	Homo sapiens	27-37
20160437-5	2010	RESULTS: Curcumin inhibited TGF-beta(1)-induced plasminogen activator inhibitor-1 (PAI-1), alpha-smooth muscle actin (alpha-SMA) mRNA and protein expression.	Curcumin	9-17	transforming growth factor beta 1	Homo sapiens	28-38
20118549-1	2010	The present study was conducted to investigate the functional and transcriptional modulation of P-glycoprotein (MDR-1) by several dietary ingredients (piperine, capsaicin, daidzein, genistein, sesamin, curcumin, taurine) in vinblastine-resistant colon carcinoma LS-180 cells (LS-180V cells).	Curcumin	202-210	ATP binding cassette subfamily B member 1	Homo sapiens	112-117
20118549-7	2010	Piperine, genistein and curcumin have been suggested to stimulate P-glycoprotein-mediated efflux without increasing P-glycoprotein expression.	Curcumin	24-32	ATP binding cassette subfamily B member 1	Homo sapiens	66-80
20118549-7	2010	Piperine, genistein and curcumin have been suggested to stimulate P-glycoprotein-mediated efflux without increasing P-glycoprotein expression.	Curcumin	24-32	ATP binding cassette subfamily B member 1	Homo sapiens	116-130
20686221-6	2010	In our study curcumin increased the expression of GADD45 and 153 in a p53-independent manner.	Curcumin	13-21	tumor protein p53	Homo sapiens	70-73
20606309-3	2010	In this study, the effect of curcumin and curcumin analogues on COX-2 expression induced by phorbol 12-myristate 13-acetate (PMA) were investigated.	Curcumin	29-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-69
20606309-3	2010	In this study, the effect of curcumin and curcumin analogues on COX-2 expression induced by phorbol 12-myristate 13-acetate (PMA) were investigated.	Curcumin	42-50	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-69
20606309-4	2010	We found that a novel curcumin analogue (GL63) inhibited PMA-induced COX-2 mRNA and protein levels in H460 cells to a greater degree than curcumin.	Curcumin	22-30	prostaglandin-endoperoxide synthase 2	Homo sapiens	69-74
20606309-7	2010	Taken together, our results provide evidence that the novel curcumin analogue can effectively inhibit PMA-induced COX-2 expression in H460 cells, a mechanism associated with COX-2 mRNA stability and post-transcriptional regulation.	Curcumin	60-68	prostaglandin-endoperoxide synthase 2	Homo sapiens	114-119
20686221-9	2010	Moreover, curcumin induced the expression of cyclin dependent kinase inhibitor genes p21 and p27, while it inhibited the expression of numerous genes, including Bcl-2, cyclin D1, CDK2, CDK4 and CDK6.	Curcumin	10-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	85-88
20606309-7	2010	Taken together, our results provide evidence that the novel curcumin analogue can effectively inhibit PMA-induced COX-2 expression in H460 cells, a mechanism associated with COX-2 mRNA stability and post-transcriptional regulation.	Curcumin	60-68	prostaglandin-endoperoxide synthase 2	Homo sapiens	174-179
20686221-9	2010	Moreover, curcumin induced the expression of cyclin dependent kinase inhibitor genes p21 and p27, while it inhibited the expression of numerous genes, including Bcl-2, cyclin D1, CDK2, CDK4 and CDK6.	Curcumin	10-18	BCL2 apoptosis regulator	Homo sapiens	161-166
20686221-9	2010	Moreover, curcumin induced the expression of cyclin dependent kinase inhibitor genes p21 and p27, while it inhibited the expression of numerous genes, including Bcl-2, cyclin D1, CDK2, CDK4 and CDK6.	Curcumin	10-18	cyclin dependent kinase 6	Homo sapiens	194-198
20388102-7	2010	In this review we consider the possibility of the natural spice curcumin, a powerful antioxidant, anti-inflammatory agent and efficient inhibitor of NF-kappaB and the mTOR signaling pathway which overlaps that of NF-kappaB, to slow down ageing.	Curcumin	64-72	nuclear factor kappa B subunit 1	Homo sapiens	149-158
21364631-5	2010	The pivotal role of the JNK/c-Jun/AP-1 pathway for gal-1-induced apoptosis was documented by reduction of DNA fragmentation after inhibition JNK by SP600125 (20 muM) or inhibition of AP-1 activation by curcumin (2 muM).	Curcumin	202-210	mitogen-activated protein kinase 8	Homo sapiens	24-27
20594343-0	2010	Curcumin mediated suppression of nuclear factor-kappaB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	33-54
20594343-5	2010	Curcumin is a phytochemical capable of inhibiting IL-1beta-induced activation of NF-kappaB and expression of apoptotic and pro-inflammatory genes in chondrocytes.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	50-58
20594343-5	2010	Curcumin is a phytochemical capable of inhibiting IL-1beta-induced activation of NF-kappaB and expression of apoptotic and pro-inflammatory genes in chondrocytes.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	81-90
20594343-6	2010	Therefore, the aim of the present study was to evaluate the influence of curcumin on IL-1beta-induced NF-kappaB signalling pathway in MSCs during chondrogenic differentiation.	Curcumin	73-81	interleukin 1 beta	Homo sapiens	85-93
20594343-6	2010	Therefore, the aim of the present study was to evaluate the influence of curcumin on IL-1beta-induced NF-kappaB signalling pathway in MSCs during chondrogenic differentiation.	Curcumin	73-81	nuclear factor kappa B subunit 1	Homo sapiens	102-111
20594343-8	2010	RESULTS: We demonstrate that although curcumin alone does not have chondrogenic effects on MSCs, it inhibits IL-1beta-induced activation of NF-kappaB, activation of caspase-3 and cyclooxygenase-2 in MSCs time and concentration dependently, as it does in chondrocytes.	Curcumin	38-46	interleukin 1 beta	Homo sapiens	109-117
20594343-8	2010	RESULTS: We demonstrate that although curcumin alone does not have chondrogenic effects on MSCs, it inhibits IL-1beta-induced activation of NF-kappaB, activation of caspase-3 and cyclooxygenase-2 in MSCs time and concentration dependently, as it does in chondrocytes.	Curcumin	38-46	nuclear factor kappa B subunit 1	Homo sapiens	140-149
20594343-8	2010	RESULTS: We demonstrate that although curcumin alone does not have chondrogenic effects on MSCs, it inhibits IL-1beta-induced activation of NF-kappaB, activation of caspase-3 and cyclooxygenase-2 in MSCs time and concentration dependently, as it does in chondrocytes.	Curcumin	38-46	caspase 3	Homo sapiens	165-174
20594343-8	2010	RESULTS: We demonstrate that although curcumin alone does not have chondrogenic effects on MSCs, it inhibits IL-1beta-induced activation of NF-kappaB, activation of caspase-3 and cyclooxygenase-2 in MSCs time and concentration dependently, as it does in chondrocytes.	Curcumin	38-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	179-195
20594343-9	2010	In IL-1beta stimulated co-cultures, four-hour pre-treatment with curcumin significantly enhanced the production of collagen type II, cartilage specific proteoglycans (CSPGs), beta1-integrin, as well as activating MAPKinase signaling and suppressing caspase-3 and cyclooxygenase-2.	Curcumin	65-73	interleukin 1 beta	Homo sapiens	3-11
20594343-9	2010	In IL-1beta stimulated co-cultures, four-hour pre-treatment with curcumin significantly enhanced the production of collagen type II, cartilage specific proteoglycans (CSPGs), beta1-integrin, as well as activating MAPKinase signaling and suppressing caspase-3 and cyclooxygenase-2.	Curcumin	65-73	caspase 3	Homo sapiens	249-258
20594343-9	2010	In IL-1beta stimulated co-cultures, four-hour pre-treatment with curcumin significantly enhanced the production of collagen type II, cartilage specific proteoglycans (CSPGs), beta1-integrin, as well as activating MAPKinase signaling and suppressing caspase-3 and cyclooxygenase-2.	Curcumin	65-73	prostaglandin-endoperoxide synthase 2	Homo sapiens	263-279
20038303-12	2010	Treatment with curcumin inhibited the expression of bcl-2 in tumor cells at the mRNA and protein levels.	Curcumin	15-23	B cell leukemia/lymphoma 2	Mus musculus	52-57
20388102-7	2010	In this review we consider the possibility of the natural spice curcumin, a powerful antioxidant, anti-inflammatory agent and efficient inhibitor of NF-kappaB and the mTOR signaling pathway which overlaps that of NF-kappaB, to slow down ageing.	Curcumin	64-72	mechanistic target of rapamycin kinase	Homo sapiens	167-171
20388102-7	2010	In this review we consider the possibility of the natural spice curcumin, a powerful antioxidant, anti-inflammatory agent and efficient inhibitor of NF-kappaB and the mTOR signaling pathway which overlaps that of NF-kappaB, to slow down ageing.	Curcumin	64-72	nuclear factor kappa B subunit 1	Homo sapiens	213-222
20968042-0	2010	[Effect of NF-kappaB activation inhibitor curcumin on the oogenesis and follicular cell death in immune ovarian failure in mice].	Curcumin	42-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	11-20
19766691-0	2010	Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	89-92
19766691-5	2010	Curcumin inhibited PMA-mediated activation of extracellular signal-regulated kinase (ERK) and NF-kappaB transcriptional activity.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	46-83
19766691-5	2010	Curcumin inhibited PMA-mediated activation of extracellular signal-regulated kinase (ERK) and NF-kappaB transcriptional activity.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	85-88
21138650-2	2010	The treatment of a squamous cervical cancer cell line, SiHa, with 20 muM curcumin and genistein resulted in demethylation of promoter of the RARbeta2 gene and led to the reactivation of the gene.	Curcumin	73-81	latexin	Homo sapiens	69-72
21138650-4	2010	In HeLa cells (an adenocarcinoma cervical cancer cell line) there was also reversal of hypermethylation of the RARbeta2 gene after six days of treatment with 20 muM curcumin.	Curcumin	165-173	latexin	Homo sapiens	161-164
20838026-3	2010	Cyclooxygenase-2 (COX-2) upregulation, but not its upstream activation of mitogen-activated protein kinases, caused by PAR2 stimulation was partially inhibited by curcumin.	Curcumin	163-171	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
19800021-6	2010	The IL-1-mediated induction of C/EBPdelta expression was attenuated in the presence of pharmacological inhibitors against c-Jun N-terminal kinase (JNK) (curcumin and SP600125), casein kinase 2 (CK2) (apigenin) and nuclear factor-kappaB (NF-kappaB) (NF-kappaB activation inhibitor).	Curcumin	153-161	mitogen-activated protein kinase 8	Homo sapiens	122-151
19800021-8	2010	IL-1 induced NF-kappaB DNA binding and activation by this transcription factor and this was attenuated by curcumin and apigenin.	Curcumin	106-114	nuclear factor kappa B subunit 1	Homo sapiens	13-22
21504136-5	2010	The addition of selective COX2 inhibitors Celebrex and curcumin to the culture medium resulted in a significant and comparable inhibition of PGE2 release, but did not inhibit Abeta42 secretion, and even significantly increased Abeta42 production in this cell system.	Curcumin	55-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-30
20838026-3	2010	Cyclooxygenase-2 (COX-2) upregulation, but not its upstream activation of mitogen-activated protein kinases, caused by PAR2 stimulation was partially inhibited by curcumin.	Curcumin	163-171	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
20838026-0	2010	Curcumin Inhibits the proteinase-activated receptor-2-triggered prostaglandin E2 production by suppressing cyclooxygenase-2 upregulation and Akt-dependent activation of nuclear factor-kappaB in human lung epithelial cells.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	107-123
20838026-0	2010	Curcumin Inhibits the proteinase-activated receptor-2-triggered prostaglandin E2 production by suppressing cyclooxygenase-2 upregulation and Akt-dependent activation of nuclear factor-kappaB in human lung epithelial cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	141-144
20838026-4	2010	Curcumin inhibited the PAR2-triggered phosphorylation of I-kappaB, an indicator for nuclear factor-kappaB (NF-kappaB) activation, and also its upstream signal Akt, which is known to contribute to PAR2-triggered PGE(2) formation, but not COX-2 upregulation.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	84-105
20838026-0	2010	Curcumin Inhibits the proteinase-activated receptor-2-triggered prostaglandin E2 production by suppressing cyclooxygenase-2 upregulation and Akt-dependent activation of nuclear factor-kappaB in human lung epithelial cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	169-190
20838026-4	2010	Curcumin inhibited the PAR2-triggered phosphorylation of I-kappaB, an indicator for nuclear factor-kappaB (NF-kappaB) activation, and also its upstream signal Akt, which is known to contribute to PAR2-triggered PGE(2) formation, but not COX-2 upregulation.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	107-116
20838026-4	2010	Curcumin inhibited the PAR2-triggered phosphorylation of I-kappaB, an indicator for nuclear factor-kappaB (NF-kappaB) activation, and also its upstream signal Akt, which is known to contribute to PAR2-triggered PGE(2) formation, but not COX-2 upregulation.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	159-162
20838026-4	2010	Curcumin inhibited the PAR2-triggered phosphorylation of I-kappaB, an indicator for nuclear factor-kappaB (NF-kappaB) activation, and also its upstream signal Akt, which is known to contribute to PAR2-triggered PGE(2) formation, but not COX-2 upregulation.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	237-242
20838026-5	2010	Collectively, curcumin inhibits the PAR2-triggered PGE(2) production by suppressing COX-2 upregulation and Akt/NF-kappaB signals in A549 cells.	Curcumin	14-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	84-89
20838026-5	2010	Collectively, curcumin inhibits the PAR2-triggered PGE(2) production by suppressing COX-2 upregulation and Akt/NF-kappaB signals in A549 cells.	Curcumin	14-22	AKT serine/threonine kinase 1	Homo sapiens	107-110
20838026-5	2010	Collectively, curcumin inhibits the PAR2-triggered PGE(2) production by suppressing COX-2 upregulation and Akt/NF-kappaB signals in A549 cells.	Curcumin	14-22	nuclear factor kappa B subunit 1	Homo sapiens	111-120
19676105-8	2010	Bax expression was unchanged but Bcl-2, survivin, phosphorylated Akt (on serine 473), and total Akt were downregulated in curcumin-treated HEY cells.	Curcumin	122-130	AKT serine/threonine kinase 1	Homo sapiens	96-99
19676105-0	2010	Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling.	Curcumin	0-8	tumor protein p53	Homo sapiens	57-60
19676105-0	2010	Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	86-122
19676105-0	2010	Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	156-161
19676105-0	2010	Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	190-193
19676105-3	2010	In this study we show that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines with differing p53 status (wild-type p53: HEY, OVCA429; mutant p53: OCC1; null p53: SKOV3).	Curcumin	27-35	tumor protein p53	Homo sapiens	158-161
19901911-14	2010	Curcumin decreased the intrahepatic gene expression of monocyte chemoattractant protein-1, CD11b, procollagen type I and tissue inhibitor of metalloprotease (TIMP)-1, together with protein levels of alpha-smooth muscle-actin, a marker of fibrogenic cells.	Curcumin	0-8	integrin alpha M	Mus musculus	91-96
19901911-14	2010	Curcumin decreased the intrahepatic gene expression of monocyte chemoattractant protein-1, CD11b, procollagen type I and tissue inhibitor of metalloprotease (TIMP)-1, together with protein levels of alpha-smooth muscle-actin, a marker of fibrogenic cells.	Curcumin	0-8	tissue inhibitor of metalloproteinase 1	Mus musculus	158-165
19901911-15	2010	In addition, curcumin reduced the generation of reactive oxygen species in cultured HSCs and inhibited the secretion of TIMP-1 both in basal conditions and after the induction of oxidative stress.	Curcumin	13-21	tissue inhibitor of metalloproteinase 1	Mus musculus	120-126
19901911-16	2010	In conclusion, curcumin administration effectively limits the development and progression of fibrosis in mice with experimental steatohepatitis, and reduces TIMP-1 secretion and oxidative stress in cultured stellate cells.	Curcumin	15-23	tissue inhibitor of metalloproteinase 1	Mus musculus	157-163
19676105-9	2010	Curcumin also activated p38 mitogen-activated protein kinase (MAPK) without altering extracellular signal-regulated kinase 1/2 activity.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	24-60
19676105-9	2010	Curcumin also activated p38 mitogen-activated protein kinase (MAPK) without altering extracellular signal-regulated kinase 1/2 activity.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	62-66
19676105-10	2010	We conclude that p53-independent curcumin-induced apoptosis in ovarian carcinoma cells involves p38 MAPK activation, ablation of prosurvival Akt signaling, and reduced expression of the antiapoptotic proteins Bcl-2 and survivin.	Curcumin	33-41	tumor protein p53	Homo sapiens	17-20
19676105-10	2010	We conclude that p53-independent curcumin-induced apoptosis in ovarian carcinoma cells involves p38 MAPK activation, ablation of prosurvival Akt signaling, and reduced expression of the antiapoptotic proteins Bcl-2 and survivin.	Curcumin	33-41	mitogen-activated protein kinase 14	Homo sapiens	96-99
19676105-3	2010	In this study we show that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines with differing p53 status (wild-type p53: HEY, OVCA429; mutant p53: OCC1; null p53: SKOV3).	Curcumin	27-35	tumor protein p53	Homo sapiens	180-183
19676105-10	2010	We conclude that p53-independent curcumin-induced apoptosis in ovarian carcinoma cells involves p38 MAPK activation, ablation of prosurvival Akt signaling, and reduced expression of the antiapoptotic proteins Bcl-2 and survivin.	Curcumin	33-41	mitogen-activated protein kinase 3	Homo sapiens	100-104
19676105-3	2010	In this study we show that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines with differing p53 status (wild-type p53: HEY, OVCA429; mutant p53: OCC1; null p53: SKOV3).	Curcumin	27-35	tumor protein p53	Homo sapiens	180-183
19676105-3	2010	In this study we show that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines with differing p53 status (wild-type p53: HEY, OVCA429; mutant p53: OCC1; null p53: SKOV3).	Curcumin	27-35	tumor protein p53	Homo sapiens	180-183
19676105-10	2010	We conclude that p53-independent curcumin-induced apoptosis in ovarian carcinoma cells involves p38 MAPK activation, ablation of prosurvival Akt signaling, and reduced expression of the antiapoptotic proteins Bcl-2 and survivin.	Curcumin	33-41	AKT serine/threonine kinase 1	Homo sapiens	141-144
19676105-6	2010	Nuclear condensation and fragmentation, as well as DNA fragmentation and poly (ADP-ribose) polymerase-1 cleavage in curcumin-treated HEY cells, indicated cell death by apoptosis.	Curcumin	116-124	poly(ADP-ribose) polymerase 1	Homo sapiens	73-103
19676105-10	2010	We conclude that p53-independent curcumin-induced apoptosis in ovarian carcinoma cells involves p38 MAPK activation, ablation of prosurvival Akt signaling, and reduced expression of the antiapoptotic proteins Bcl-2 and survivin.	Curcumin	33-41	BCL2 apoptosis regulator	Homo sapiens	209-214
19676105-7	2010	Procaspase-3, procaspase-8, and procaspase-9 cleavage, in addition to cytochrome c release and Bid cleavage into truncated Bid, revealed that curcumin activated both the extrinsic and intrinsic pathways of apoptosis.	Curcumin	142-150	caspase 3	Homo sapiens	0-12
19676105-7	2010	Procaspase-3, procaspase-8, and procaspase-9 cleavage, in addition to cytochrome c release and Bid cleavage into truncated Bid, revealed that curcumin activated both the extrinsic and intrinsic pathways of apoptosis.	Curcumin	142-150	cytochrome c, somatic	Homo sapiens	70-82
20358476-5	2010	Curcumin-treated PC3 cells showed apoptosis-inducing cellular ceramide accumulation and activation of p38 mitogen-activated protein kinase (MAPK) and c-jun N-terminal kinase (JNK).	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	102-138
19676105-7	2010	Procaspase-3, procaspase-8, and procaspase-9 cleavage, in addition to cytochrome c release and Bid cleavage into truncated Bid, revealed that curcumin activated both the extrinsic and intrinsic pathways of apoptosis.	Curcumin	142-150	BH3 interacting domain death agonist	Homo sapiens	95-98
19676105-7	2010	Procaspase-3, procaspase-8, and procaspase-9 cleavage, in addition to cytochrome c release and Bid cleavage into truncated Bid, revealed that curcumin activated both the extrinsic and intrinsic pathways of apoptosis.	Curcumin	142-150	BH3 interacting domain death agonist	Homo sapiens	123-126
19676105-8	2010	Bax expression was unchanged but Bcl-2, survivin, phosphorylated Akt (on serine 473), and total Akt were downregulated in curcumin-treated HEY cells.	Curcumin	122-130	BCL2 associated X, apoptosis regulator	Homo sapiens	0-3
19676105-8	2010	Bax expression was unchanged but Bcl-2, survivin, phosphorylated Akt (on serine 473), and total Akt were downregulated in curcumin-treated HEY cells.	Curcumin	122-130	BCL2 apoptosis regulator	Homo sapiens	33-38
19676105-8	2010	Bax expression was unchanged but Bcl-2, survivin, phosphorylated Akt (on serine 473), and total Akt were downregulated in curcumin-treated HEY cells.	Curcumin	122-130	AKT serine/threonine kinase 1	Homo sapiens	65-68
20358476-5	2010	Curcumin-treated PC3 cells showed apoptosis-inducing cellular ceramide accumulation and activation of p38 mitogen-activated protein kinase (MAPK) and c-jun N-terminal kinase (JNK).	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	150-173
20358476-5	2010	Curcumin-treated PC3 cells showed apoptosis-inducing cellular ceramide accumulation and activation of p38 mitogen-activated protein kinase (MAPK) and c-jun N-terminal kinase (JNK).	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	175-178
20358476-6	2010	Caspase-3, caspase-8, and caspase-9 were activated, and cytochrome c and apoptosis-inducing factor (AIF) were released from mitochondria following curcumin treatment.	Curcumin	147-155	caspase 3	Homo sapiens	0-9
20358476-6	2010	Caspase-3, caspase-8, and caspase-9 were activated, and cytochrome c and apoptosis-inducing factor (AIF) were released from mitochondria following curcumin treatment.	Curcumin	147-155	cytochrome c, somatic	Homo sapiens	56-68
20661831-5	2010	Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak).	Curcumin	15-23	caspase 3	Homo sapiens	127-136
20661831-5	2010	Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak).	Curcumin	15-23	BH3 interacting domain death agonist	Homo sapiens	166-169
20661831-7	2010	Caspase-8 inhibition abrogated Bid cleavage and strongly reduced caspase-9 activation, suggesting that the cross-talk mechanism mediated by caspase-8-dependent Bid cleavage can contribute to the activation of the intrinsic apoptotic pathway by curcumin + carnosic acid.	Curcumin	244-252	BH3 interacting domain death agonist	Homo sapiens	160-163
20661831-5	2010	Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak).	Curcumin	15-23	BCL2 apoptosis regulator	Homo sapiens	228-233
20661831-5	2010	Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak).	Curcumin	15-23	BCL2 apoptosis regulator	Homo sapiens	251-256
20661831-5	2010	Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak).	Curcumin	15-23	BCL2 like 1	Homo sapiens	258-264
20661831-5	2010	Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak).	Curcumin	15-23	BCL2 associated X, apoptosis regulator	Homo sapiens	273-276
20661831-7	2010	Caspase-8 inhibition abrogated Bid cleavage and strongly reduced caspase-9 activation, suggesting that the cross-talk mechanism mediated by caspase-8-dependent Bid cleavage can contribute to the activation of the intrinsic apoptotic pathway by curcumin + carnosic acid.	Curcumin	244-252	BH3 interacting domain death agonist	Homo sapiens	31-34
19955845-9	2010	In HG-stimulated RAECs, curcumin attenuated the nuclear translocation of p65 and decreased the NFkappaB DNA-binding activity.	Curcumin	24-32	synaptotagmin 1	Rattus norvegicus	73-76
21071923-0	2010	Curcumin facilitates fibrinolysis and cellular migration during wound healing by modulating urokinase plasminogen activator expression.	Curcumin	0-8	plasminogen activator, urokinase	Homo sapiens	92-123
21071923-4	2010	This study focused on the effect of curcumin on uPA expression and its consequence on fibrin dissolution and cellular migration.	Curcumin	36-44	plasminogen activator, urokinase	Homo sapiens	48-51
21071923-5	2010	Treatment of human fibroblast cells with curcumin caused an upregulation of uPA mRNA and protein.	Curcumin	41-49	plasminogen activator, urokinase	Homo sapiens	76-79
19955845-9	2010	In HG-stimulated RAECs, curcumin attenuated the nuclear translocation of p65 and decreased the NFkappaB DNA-binding activity.	Curcumin	24-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-103
19955845-10	2010	CONCLUSION: Curcumin blocks HG-induced MCP-1 synthesis in RAECs partly via the NFkappaB pathway.	Curcumin	12-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	79-87
20180411-0	2010	[Reducing effect of curcumin on expressions of TNF-alpha, IL-6 and IL-8 in rats with chronic nonbacterial prostatitis].	Curcumin	20-28	tumor necrosis factor	Rattus norvegicus	47-56
20160430-6	2010	Curcumin-induced apoptosis involved suppression of Bcl-2, stimulation of cleaved caspase-3 and induction of DNA fragmentation.	Curcumin	0-8	B cell leukemia/lymphoma 2	Mus musculus	51-56
20160430-8	2010	Immune-like functions of FS cells were impaired since curcumin downregulated Toll-like receptor 4, reduced nuclear factor-kappaB expression and suppressed bacterial endotoxin-induced interleukin-6 (IL-6) secretion.	Curcumin	54-62	interleukin 6	Mus musculus	183-196
20160430-8	2010	Immune-like functions of FS cells were impaired since curcumin downregulated Toll-like receptor 4, reduced nuclear factor-kappaB expression and suppressed bacterial endotoxin-induced interleukin-6 (IL-6) secretion.	Curcumin	54-62	interleukin 6	Mus musculus	198-202
20160430-9	2010	The inhibitory action of curcumin on VEGF-A and IL-6 production was also found in primary rat pituitary cell cultures, in which FS cells are the only source of these proteins.	Curcumin	25-33	interleukin 6	Rattus norvegicus	48-52
20180411-0	2010	[Reducing effect of curcumin on expressions of TNF-alpha, IL-6 and IL-8 in rats with chronic nonbacterial prostatitis].	Curcumin	20-28	interleukin 6	Rattus norvegicus	58-62
20180411-1	2010	OBJECTIVE: To investigate the effects of curcumin on the expressions of TNF-alpha, IL-6 and IL-8 in rats with chronic nonbacterial prostatitis.	Curcumin	41-49	tumor necrosis factor	Rattus norvegicus	72-81
20180411-1	2010	OBJECTIVE: To investigate the effects of curcumin on the expressions of TNF-alpha, IL-6 and IL-8 in rats with chronic nonbacterial prostatitis.	Curcumin	41-49	interleukin 6	Rattus norvegicus	83-87
20180411-6	2010	RESULTS: The levels of TNF-alpha and IL-8 in the serum and prostate tissues were significantly lower in the intraperitoneal curcumin than in the positive control group (P &lt; 0.05), but the expression of IL-6 showed no significant difference between the two groups (P &gt; 0.01).	Curcumin	124-132	tumor necrosis factor	Rattus norvegicus	23-32
20180411-7	2010	CONCLUSION: Curcumin is efficacious for chronic nonbacterial prostatitis in rats, and the action mechanism may be associated with its decreasing effect on the proinflammatory cytokines IL-8 and TNF-alpha in the blood and tissues.	Curcumin	12-20	tumor necrosis factor	Rattus norvegicus	194-203
20030852-5	2009	We show that CXCL1 a chemokine that is down regulated in breast cancer cells by Curcumin in an NFkappaB dependent manner is expressed at variable levels in human melanomas.	Curcumin	80-88	nuclear factor kappa B subunit 1	Homo sapiens	95-103
20030852-9	2009	Gene silencing of ABCA1 by siRNA sensitizes M14 cells to the apoptotic effect of Curcumin most likely as a result of reduced basal levels of active NFkappaB.	Curcumin	81-89	nuclear factor kappa B subunit 1	Homo sapiens	148-156
20975915-7	2009	In the present study, five antioxidants, namely lycopene, ascorbic acid, alpha-tocopherol, curcumin and curcumin dipiperoyl ester which are potent scavengers of reactive oxygen species (ROS) have been docked to HIF-1 alpha modeled protein in order to assess their binding and consequently, their inhibitory activity.	Curcumin	91-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	211-222
20337222-0	2009	Anti-ulcer activity of curcumin on experimental gastric ulcer in rats and its effect on oxidative stress/antioxidant, IL-6 and enzyme activities.	Curcumin	23-31	interleukin 6	Rattus norvegicus	118-122
20044614-12	2009	CONCLUSION: Our results demonstrated that curcumin caused death of HOS cells by blocking cells successively in G(1)/S and G(2)/M phases and activating the caspase-3 pathway.	Curcumin	42-50	caspase 3	Homo sapiens	155-164
20337222-10	2009	RESULTS: The anti-ulcer activity of curcumin was displayed by attenuating the different ulcerative effectors including gastric acid hyper-secretion, total peroxides, myeloperoxiase (MPO) activity, IL-6 and apoptotic incidence.	Curcumin	36-44	interleukin 6	Rattus norvegicus	197-201
19473187-13	2009	The curcumin-loaded nanofibres also reduced inflammatory induction, as evidenced by low levels of interleukin-6 release from mouse monocyte-macrophages seeded onto the fibres following stimulation by Escherichia coli-derived lipopolysaccharide.	Curcumin	4-12	interleukin 6	Mus musculus	98-111
19772879-0	2009	Multifunctional role of VIP in prostate cancer progression in a xenograft model: suppression by curcumin and COX-2 inhibitor NS-398.	Curcumin	96-104	vasoactive intestinal polypeptide	Mus musculus	24-27
19726538-7	2009	Induction of DNA fragmentation, reduction of Bcl-2 and enhancement of cleaved caspase-3 further confirmed induction of apoptosis by curcumin.	Curcumin	132-140	B cell leukemia/lymphoma 2	Mus musculus	45-50
19808779-0	2009	Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1.	Curcumin	0-8	sterol regulatory element binding transcription factor 2	Homo sapiens	18-25
19808779-0	2009	Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1.	Curcumin	0-8	Sp1 transcription factor	Homo sapiens	110-131
19808779-3	2009	We previously reported that curcumin induced gene expression of peroxisome proliferator-activated receptor (PPAR)-gamma and stimulated its activity, leading to the inhibition of the activation of hepatic stellate cells (HSCs), the major effector cells during hepatic fibrogenesis.	Curcumin	28-36	peroxisome proliferator activated receptor gamma	Homo sapiens	64-119
19808779-4	2009	We recently showed that curcumin suppressed gene expression of LDL receptor in activated HSCs in vitro by repressing gene expression of the transcription factor sterol regulatory element binding protein-2 (SREBP-2), leading to the reduction in the level of intracellular cholesterol in HSCs and to the attenuation of the stimulatory effects of LDL on HSCs activation.	Curcumin	24-32	sterol regulatory element binding transcription factor 2	Homo sapiens	161-204
19808779-4	2009	We recently showed that curcumin suppressed gene expression of LDL receptor in activated HSCs in vitro by repressing gene expression of the transcription factor sterol regulatory element binding protein-2 (SREBP-2), leading to the reduction in the level of intracellular cholesterol in HSCs and to the attenuation of the stimulatory effects of LDL on HSCs activation.	Curcumin	24-32	sterol regulatory element binding transcription factor 2	Homo sapiens	206-213
19808779-5	2009	The current study aimed at exploring molecular mechanisms by which curcumin inhibits srebp-2 expression in HSCs.	Curcumin	67-75	sterol regulatory element binding transcription factor 2	Homo sapiens	85-92
19808779-6	2009	Promoter deletion assays, mutagenesis assays, and EMSAs localize a specificity protein-1 (SP-1) binding GC-box in the srebp-2 promoter, which is responsible for enhancing the promoter activity and responding to curcumin in HSCs.	Curcumin	211-219	Sp1 transcription factor	Homo sapiens	67-88
19808779-6	2009	Promoter deletion assays, mutagenesis assays, and EMSAs localize a specificity protein-1 (SP-1) binding GC-box in the srebp-2 promoter, which is responsible for enhancing the promoter activity and responding to curcumin in HSCs.	Curcumin	211-219	sterol regulatory element binding transcription factor 2	Homo sapiens	118-125
19808779-7	2009	Curcumin suppresses gene expression of SP-1 and reduces its trans-activation activity, which are mediated by the activation of PPARgamma.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	127-136
19808779-9	2009	In summary, our results demonstrate that curcumin inhibits srebp-2 expression in cultured HSCs by activating PPARgamma and reducing the SP-1 activity, leading to the repression of ldlr expression.	Curcumin	41-49	sterol regulatory element binding transcription factor 2	Homo sapiens	59-66
19808779-9	2009	In summary, our results demonstrate that curcumin inhibits srebp-2 expression in cultured HSCs by activating PPARgamma and reducing the SP-1 activity, leading to the repression of ldlr expression.	Curcumin	41-49	peroxisome proliferator activated receptor gamma	Homo sapiens	109-118
19772879-4	2009	A selective COX-2 inhibitor, NS-398, and curcumin were used to block VIP effects.	Curcumin	41-49	vasoactive intestinal polypeptide	Mus musculus	69-72
19772879-8	2009	The overexpression of the above biomarkers was suppressed in tumors derived from VIP-treated PC3 cells that had been previously incubated with curcumin or NS-398.	Curcumin	143-151	vasoactive intestinal polypeptide	Mus musculus	81-84
19956394-6	2009	Treatment of FOLFOX-surviving colon cancer cells with either curcumin alone or together with FOLFOX resulted in a marked reduction in CSCs, as evidenced by the decreased expression of CD44 and CD166 as well as EGFR and by their ability to form anchorage-dependent colonies.	Curcumin	61-69	epidermal growth factor receptor	Homo sapiens	210-214
19956394-8	2009	Increased expression of EGFR in FOLFOX-surviving cells could be attributed to hypomethylation of the EGFR promoter, whereas an opposite phenomenon was observed when the FOLFOX-surviving cells were treated with curcumin and/or FOLFOX.	Curcumin	210-218	epidermal growth factor receptor	Homo sapiens	24-28
21351482-3	2009	Curcumin (50 micromol x L(-1)) significantly increased phosphorylations of p38 (T180/Y182) and STAT-1 (S727) in Huh7 and Hep3B cells, and caused relocalization of phosphorylated-STAT-1 (Y701) from cytoplasm to nucleus in Hep3B cells.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	75-78
19996301-7	2009	We further show that curcumin, a dietary compound, can selectively inhibit ectopic fVII expression by targeting p300/CBP activity.	Curcumin	21-29	CREB binding protein	Homo sapiens	117-120
19477063-0	2009	Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF).	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	141-175
19477063-0	2009	Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF).	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	177-181
19850041-0	2009	Inhibition of aldose reductase by dietary antioxidant curcumin: mechanism of inhibition, specificity and significance.	Curcumin	54-62	aldo-keto reductase family 1 member B	Homo sapiens	14-30
19850041-2	2009	In this study we show that curcumin inhibits ALR2 with an IC(50) of 10 microM in a non-competitive manner, but is a poor inhibitor of closely-related members of the aldo-keto reductase superfamily, particularly aldehyde reductase.	Curcumin	27-35	aldo-keto reductase family 1 member B	Homo sapiens	45-49
19850041-3	2009	Results from molecular docking studies are consistent with the pattern of inhibition of ALR2 by curcumin and its specificity.	Curcumin	96-104	aldo-keto reductase family 1 member B	Homo sapiens	88-92
19580791-8	2009	A subsequent p53/p21(CIP1/WAF1)-dependent inhibition of G1 to S transition is triggered by Curcumin and DAC as a consequence of the mitotic slippage, preventing post-mitotic cells from re-entering the cell cycle.	Curcumin	91-99	tumor protein p53	Homo sapiens	13-16
19580791-8	2009	A subsequent p53/p21(CIP1/WAF1)-dependent inhibition of G1 to S transition is triggered by Curcumin and DAC as a consequence of the mitotic slippage, preventing post-mitotic cells from re-entering the cell cycle.	Curcumin	91-99	cyclin dependent kinase inhibitor 1A	Homo sapiens	17-20
19580791-8	2009	A subsequent p53/p21(CIP1/WAF1)-dependent inhibition of G1 to S transition is triggered by Curcumin and DAC as a consequence of the mitotic slippage, preventing post-mitotic cells from re-entering the cell cycle.	Curcumin	91-99	cyclin dependent kinase inhibitor 1A	Homo sapiens	21-25
19580791-8	2009	A subsequent p53/p21(CIP1/WAF1)-dependent inhibition of G1 to S transition is triggered by Curcumin and DAC as a consequence of the mitotic slippage, preventing post-mitotic cells from re-entering the cell cycle.	Curcumin	91-99	cyclin dependent kinase inhibitor 1A	Homo sapiens	26-30
19740743-5	2009	Both mature CFTR polypeptides at the cell surface and immature CFTR protein in the endoplasmic reticulum were cross-linked by curcumin, although the latter pool was more susceptible to this modification.	Curcumin	126-134	CF transmembrane conductance regulator	Homo sapiens	12-16
19715674-2	2009	Recent reports have shown curcumin to have antioxidant, anti-inflammatory and anti-tumor properties as well as affecting the 5"-AMP activated protein kinase (AMPK), mTOR and STAT-3 signaling pathways.	Curcumin	26-34	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	125-156
19715674-2	2009	Recent reports have shown curcumin to have antioxidant, anti-inflammatory and anti-tumor properties as well as affecting the 5"-AMP activated protein kinase (AMPK), mTOR and STAT-3 signaling pathways.	Curcumin	26-34	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	158-162
19740743-5	2009	Both mature CFTR polypeptides at the cell surface and immature CFTR protein in the endoplasmic reticulum were cross-linked by curcumin, although the latter pool was more susceptible to this modification.	Curcumin	126-134	CF transmembrane conductance regulator	Homo sapiens	63-67
19740743-0	2009	Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	21-72
19740743-0	2009	Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	74-78
19703194-0	2009	Curcumin reduced the side effects of mitomycin C by inhibiting GRP58-mediated DNA cross-linking in MCF-7 breast cancer xenografts.	Curcumin	0-8	protein disulfide isomerase family A member 3	Homo sapiens	63-68
19740743-0	2009	Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	109-113
19740743-2	2009	Wild type and mutant CFTR channels can be activated by curcumin, a well tolerated dietary compound with some appeal as a prospective CF therapeutic.	Curcumin	55-63	CF transmembrane conductance regulator	Homo sapiens	21-25
19740743-3	2009	However, we show here that curcumin has the unexpected effect of cross-linking CFTR polypeptides into SDS-resistant oligomers.	Curcumin	27-35	CF transmembrane conductance regulator	Homo sapiens	79-83
19821579-4	2009	Two copies of Abeta-binding motifs (either curcumin or the KLVFFA peptide) are clicked via copper(I)-mediated azide-alkyne cycloaddition on a constrained cyclopeptide scaffold designed to interfere with Abeta aggregation.	Curcumin	43-51	amyloid beta precursor protein	Homo sapiens	14-19
19762916-4	2009	Members of the activator protein 1 (AP-1) and specificity protein 1 (Sp1) family of transcription factors are necessary for the transcriptional regulation of the XYLT1 gene, which was proven by curcumin, tanshinone IIA, mithramycin A, and short interference RNA treatment.	Curcumin	194-202	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-34
19762916-4	2009	Members of the activator protein 1 (AP-1) and specificity protein 1 (Sp1) family of transcription factors are necessary for the transcriptional regulation of the XYLT1 gene, which was proven by curcumin, tanshinone IIA, mithramycin A, and short interference RNA treatment.	Curcumin	194-202	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	36-40
19762916-4	2009	Members of the activator protein 1 (AP-1) and specificity protein 1 (Sp1) family of transcription factors are necessary for the transcriptional regulation of the XYLT1 gene, which was proven by curcumin, tanshinone IIA, mithramycin A, and short interference RNA treatment.	Curcumin	194-202	Sp1 transcription factor	Homo sapiens	46-67
19845678-10	2009	Induction of HO-1 by curcumin or haemin protected against TNFalpha-induced hyporesponsiveness to ACh.	Curcumin	21-29	tumor necrosis factor	Rattus norvegicus	58-66
19703194-7	2009	In conclusion, the current study provided evidence that MMC and curcumin combination treatment reduced MMC side effects by inhibiting GRP58-mediated DNA cross-linking through the ERK/p38 MAPK pathway.	Curcumin	64-72	protein disulfide isomerase family A member 3	Homo sapiens	134-139
19703194-7	2009	In conclusion, the current study provided evidence that MMC and curcumin combination treatment reduced MMC side effects by inhibiting GRP58-mediated DNA cross-linking through the ERK/p38 MAPK pathway.	Curcumin	64-72	mitogen-activated protein kinase 14	Homo sapiens	183-186
19839007-6	2009	We report here that curcumin modulated BM-derived DC to express ALDH1a and IL-10.	Curcumin	20-28	interleukin 10	Mus musculus	75-80
19839007-7	2009	These curcumin-treated DC induced differentiation of naive CD4(+) T cells into Treg resembling Treg in the intestine, including both CD4(+)CD25(+) Foxp3(+) Treg and IL-10-producing Tr1 cells.	Curcumin	6-14	interleukin 10	Mus musculus	165-170
19839007-8	2009	Such Treg induction required IL-10, TGF-beta and retinoic acid produced by curcumin-modulated DC.	Curcumin	75-83	interleukin 10	Mus musculus	29-34
19623659-0	2009	Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
19623659-0	2009	Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	102-106
19736547-8	2009	This suppressive effect of curcumin results from the interruption of Wnt signaling and the activation of peroxisome proliferator-activated receptor-gamma (PPARgamma).	Curcumin	27-35	peroxisome proliferator activated receptor gamma	Homo sapiens	105-153
20183254-5	2009	Furthermore, curcumin-induced cell death was associated with the formation of the apoptosome complex, the collapse of the mitochondrial membrane potential, and caspase-3 activation.	Curcumin	13-21	caspase 3	Homo sapiens	160-169
20183254-6	2009	Curcumin treatment also induced Bid cleavage and downregulated the expression of Bcl-2 protein.	Curcumin	0-8	BH3 interacting domain death agonist	Homo sapiens	32-35
20183254-6	2009	Curcumin treatment also induced Bid cleavage and downregulated the expression of Bcl-2 protein.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	81-86
20134045-7	2009	Inhibition of NF-kappaB with curcumin or parthenolide resulted in a decrease of IL-8 secretion.	Curcumin	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
19736547-8	2009	This suppressive effect of curcumin results from the interruption of Wnt signaling and the activation of peroxisome proliferator-activated receptor-gamma (PPARgamma).	Curcumin	27-35	peroxisome proliferator activated receptor gamma	Homo sapiens	155-164
19736547-9	2009	In conclusion, these results support our initial hypothesis and demonstrate that ox-LDL stimulates HSC activation, which is eliminated by curcumin by suppressing lox-1 expression by interrupting Wnt signaling and stimulating PPARgamma activity.	Curcumin	138-146	peroxisome proliferator activated receptor gamma	Homo sapiens	225-234
19665995-7	2009	Furthermore, curcuminoids increased the phosphorylation of AMP-activated protein kinase (AMPK) and its downstream target acetyl-CoA carboxylase (ACC) in H4IIE and Hep3B cells with 400 times (curcumin) to 100,000 times (THC) the potency of metformin.	Curcumin	13-21	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	59-87
20079164-5	2009	Sox9 and collagen type II expression during treatment with IL-1, with or without the nuclear factor-kappaB (NF-kappaB) activity inhibitor curcumin, were detected by using reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting, and the activity of the NF-kappaB signaling pathway was detected by the electrophoretic mobility shift assay (EMSA).	Curcumin	138-146	nuclear factor kappa B subunit 1	Homo sapiens	85-106
20079164-5	2009	Sox9 and collagen type II expression during treatment with IL-1, with or without the nuclear factor-kappaB (NF-kappaB) activity inhibitor curcumin, were detected by using reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting, and the activity of the NF-kappaB signaling pathway was detected by the electrophoretic mobility shift assay (EMSA).	Curcumin	138-146	nuclear factor kappa B subunit 1	Homo sapiens	108-117
20079164-8	2009	IL-1 at concentrations of 0.1 ng/ml, 1 ng/ml and 10 ng/ml could stimulate the activity of NF-kappaB in the intervertebral disc cells in a dose dependent manner (P &lt; 0.05) that was inhibited by curcumin.	Curcumin	196-204	nuclear factor kappa B subunit 1	Homo sapiens	90-99
20079164-10	2009	This inhibition can be attenuated by curcumin, which is an effective NF-kappaB activity inhibitor.	Curcumin	37-45	nuclear factor kappa B subunit 1	Homo sapiens	69-78
19665995-7	2009	Furthermore, curcuminoids increased the phosphorylation of AMP-activated protein kinase (AMPK) and its downstream target acetyl-CoA carboxylase (ACC) in H4IIE and Hep3B cells with 400 times (curcumin) to 100,000 times (THC) the potency of metformin.	Curcumin	13-21	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	89-93
19481068-10	2009	Curcumin and AG suppressed selenium-induced oxidative stress and cataract formation in isolated lens from Wistar rat pups, possibly by inhibiting depletion of enzymic as well as non-enzymic antioxidants, and preventing uncontrolled generation of free radicals and also by inhibiting iNOS expression.	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	283-287
19573523-9	2009	The expression levels of two integral proteins of Wnt signaling, GSK3beta and E-cadherin were also altered by curcumin treatment.	Curcumin	110-118	cadherin 1	Homo sapiens	78-88
19823063-11	2009	Treatment with curcumin inhibited the expression of Bcl-2 in tumor cells at the mRNA and protein levels.	Curcumin	15-23	B cell leukemia/lymphoma 2	Mus musculus	52-57
19631254-4	2009	The results suggest that curcumin protects cultured rat primary prefrontal cortical neurons against Abeta-induced cytotoxicity, and both Bcl2 and caspase-3 are involved in the curcumin-induced protective effects.	Curcumin	176-184	BCL2, apoptosis regulator	Rattus norvegicus	137-141
19663790-0	2009	Novel anti-prostate cancer curcumin analogues that enhance androgen receptor degradation activity.	Curcumin	27-35	androgen receptor	Homo sapiens	59-76
19303754-10	2009	Curcumin also decreased the nuclear levels of NFkappaB.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	46-54
19724924-0	2009	Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	35-40
19735878-0	2009	Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	109-118
19735878-6	2009	We characterized the transcription factor nuclear factor-kappaB (NF-kappaB) activation as a mechanism of inducible radioresistance in colorectal cancer and used curcumin, the active ingredient in the yellow spice turmeric, to overcome this resistance.	Curcumin	161-169	nuclear factor kappa B subunit 1	Homo sapiens	65-74
19735878-8	2009	Radiation stimulated NF-kappaB activity in a dose- and time-dependent manner, whereas curcumin suppressed this radiation-induced NF-kappaB activation via inhibition of radiation-induced phosphorylation and degradation of inhibitor of kappaB alpha, inhibition of inhibitor of kappaB kinase activity, and inhibition of Akt phosphorylation.	Curcumin	86-94	nuclear factor kappa B subunit 1	Homo sapiens	129-138
19735878-9	2009	Curcumin also suppressed NF-kappaB-regulated gene products (Bcl-2, Bcl-x(L), inhibitor of apoptosis protein-2, cyclooxygenase-2, and cyclin D1).	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	25-34
19735878-9	2009	Curcumin also suppressed NF-kappaB-regulated gene products (Bcl-2, Bcl-x(L), inhibitor of apoptosis protein-2, cyclooxygenase-2, and cyclin D1).	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	60-65
19735878-9	2009	Curcumin also suppressed NF-kappaB-regulated gene products (Bcl-2, Bcl-x(L), inhibitor of apoptosis protein-2, cyclooxygenase-2, and cyclin D1).	Curcumin	0-8	BCL2 like 1	Homo sapiens	67-109
19735878-9	2009	Curcumin also suppressed NF-kappaB-regulated gene products (Bcl-2, Bcl-x(L), inhibitor of apoptosis protein-2, cyclooxygenase-2, and cyclin D1).	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	111-127
19655336-8	2009	Curcumin decreased COX-2 expression and inhibited phosphorylation of EGFR in SCC-1 cells.	Curcumin	0-8	protein tyrosine phosphatase, receptor type, J	Mus musculus	77-82
19524420-0	2009	Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcription.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	113-121
19723087-0	2009	Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells.	Curcumin	10-18	nuclear factor kappa B subunit 1	Homo sapiens	37-43
19524420-7	2009	The expressions of NFkappaB in breast cancer cells treated with curcumin were studied by immunochemistry and western blot.	Curcumin	64-72	nuclear factor kappa B subunit 1	Homo sapiens	19-27
19524420-11	2009	Our finding extrapolates the antitumor activity of curcumin in mediating the breast cancer cell proliferative rate and invasion by down-regulating the NFkappaB inducing genes.	Curcumin	51-59	nuclear factor kappa B subunit 1	Homo sapiens	151-159
19685877-6	2009	Furthermore, EEAP, apigenin, curcumin, and pinocembrin decreased LPS-mediated induction of protein and mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in RAW 264.7 cells.	Curcumin	29-37	nitric oxide synthase 2, inducible	Mus musculus	122-153
19685877-6	2009	Furthermore, EEAP, apigenin, curcumin, and pinocembrin decreased LPS-mediated induction of protein and mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in RAW 264.7 cells.	Curcumin	29-37	nitric oxide synthase 2, inducible	Mus musculus	155-159
20379410-8	2009	CONCLUSIONS: Insulin (1 mug/ml) exerted cytoproliferative and curcumin exerted cytocidal effects (in a dose-dependent manner) on hPGF.	Curcumin	62-70	placental growth factor	Homo sapiens	129-133
20379410-9	2009	Insulin (1 mug/ml) and curcumin at different concentrations when added together decreased the cytocidal effect of curcumin.	Curcumin	114-122	insulin	Homo sapiens	0-7
19723881-4	2009	Immunoblot analysis confirmed that curcumin induced apoptosis and revealed caspase-3 processing, poly ADP ribose polymerase cleavage, reduced Bcl-2, and decreased basal phosphorylated signal transducers and activators of transcription 3 (STAT3).	Curcumin	35-43	BCL2 apoptosis regulator	Homo sapiens	142-147
19723881-4	2009	Immunoblot analysis confirmed that curcumin induced apoptosis and revealed caspase-3 processing, poly ADP ribose polymerase cleavage, reduced Bcl-2, and decreased basal phosphorylated signal transducers and activators of transcription 3 (STAT3).	Curcumin	35-43	signal transducer and activator of transcription 3	Homo sapiens	184-236
19723881-4	2009	Immunoblot analysis confirmed that curcumin induced apoptosis and revealed caspase-3 processing, poly ADP ribose polymerase cleavage, reduced Bcl-2, and decreased basal phosphorylated signal transducers and activators of transcription 3 (STAT3).	Curcumin	35-43	signal transducer and activator of transcription 3	Homo sapiens	238-243
19723881-5	2009	Despite its proapoptotic effects, curcumin pretreatment of human melanoma cell lines inhibited the phosphorylation of STAT1 protein and downstream gene transcription following IFN-alpha and IFN-gamma as determined by immunoblot analysis and real time PCR, respectively.	Curcumin	34-42	interferon alpha 1	Homo sapiens	176-185
19723881-5	2009	Despite its proapoptotic effects, curcumin pretreatment of human melanoma cell lines inhibited the phosphorylation of STAT1 protein and downstream gene transcription following IFN-alpha and IFN-gamma as determined by immunoblot analysis and real time PCR, respectively.	Curcumin	34-42	interferon gamma	Homo sapiens	190-199
19723881-6	2009	Pretreatment of peripheral blood mononuclear cells from healthy donors with curcumin also inhibited the ability of IFN-alpha, IFN-gamma, and interleukin-2 to phosphorylate STAT proteins critical for their antitumor activity (STAT1 and STAT5, respectively) and their respective downstream gene expression as measured by real time PCR.	Curcumin	76-84	interferon alpha 1	Homo sapiens	115-124
19723881-6	2009	Pretreatment of peripheral blood mononuclear cells from healthy donors with curcumin also inhibited the ability of IFN-alpha, IFN-gamma, and interleukin-2 to phosphorylate STAT proteins critical for their antitumor activity (STAT1 and STAT5, respectively) and their respective downstream gene expression as measured by real time PCR.	Curcumin	76-84	interferon gamma	Homo sapiens	126-135
19723881-6	2009	Pretreatment of peripheral blood mononuclear cells from healthy donors with curcumin also inhibited the ability of IFN-alpha, IFN-gamma, and interleukin-2 to phosphorylate STAT proteins critical for their antitumor activity (STAT1 and STAT5, respectively) and their respective downstream gene expression as measured by real time PCR.	Curcumin	76-84	interleukin 2	Homo sapiens	141-154
19723881-7	2009	Finally, stimulation of natural killer (NK) cells with curcumin reduced the level of interleukin-12-induced IFN-gamma secretion, and production of granzyme b or IFN-gamma upon coculture with A375 melanoma cells or NK-sensitive K562 cells as targets.	Curcumin	55-63	interferon gamma	Homo sapiens	108-117
19723881-7	2009	Finally, stimulation of natural killer (NK) cells with curcumin reduced the level of interleukin-12-induced IFN-gamma secretion, and production of granzyme b or IFN-gamma upon coculture with A375 melanoma cells or NK-sensitive K562 cells as targets.	Curcumin	55-63	interferon gamma	Homo sapiens	161-170
19520742-0	2009	Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcumin.	Curcumin	164-172	vascular cell adhesion molecule 1	Homo sapiens	0-33
19661333-0	2009	Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	70-73
19661333-0	2009	Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	74-78
19661333-5	2009	Curcumin decreased total expression of mTOR, Raptor and Rictor protein and mRNA levels.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	39-43
19661333-6	2009	Surprisingly, curcumin induced phosphorylation of Akt(Ser 473); this effect may be attributed to a decrease in levels of the PHLPP1 phosphatase, an inhibitor of Akt.	Curcumin	14-22	AKT serine/threonine kinase 1	Homo sapiens	50-53
19661333-6	2009	Surprisingly, curcumin induced phosphorylation of Akt(Ser 473); this effect may be attributed to a decrease in levels of the PHLPP1 phosphatase, an inhibitor of Akt.	Curcumin	14-22	AKT serine/threonine kinase 1	Homo sapiens	161-164
19661333-7	2009	CONCLUSION: Our data suggest that curcumin, a natural compound, may exert its antiproliferative effects by inhibition of mTOR signaling and thus may represent a novel class of mTOR inhibitor.	Curcumin	34-42	mechanistic target of rapamycin kinase	Homo sapiens	121-125
19661333-7	2009	CONCLUSION: Our data suggest that curcumin, a natural compound, may exert its antiproliferative effects by inhibition of mTOR signaling and thus may represent a novel class of mTOR inhibitor.	Curcumin	34-42	mechanistic target of rapamycin kinase	Homo sapiens	176-180
20379410-0	2009	Role of insulin as a growth promoter in regulating the response of curcumin in human primary gingival fibroblasts: An in vitro study.	Curcumin	67-75	insulin	Homo sapiens	8-15
20379410-1	2009	BACKGROUND: The aim of this investigation was to evaluate the biochemical and morphologic changes in human primary gingival fibroblasts (hPGF) treated with curcumin (CUR) and insulin (I) plus curcumin (CUR) in a dose-dependent fashion.	Curcumin	156-164	placental growth factor	Homo sapiens	137-141
19693275-4	2009	Curcumin predominantly induced mitochondria-mediated ROS formation and stimulated the expression of the redox-sensitive pro-apoptotic factor p53.	Curcumin	0-8	tumor protein p53	Homo sapiens	141-144
19693275-12	2009	Curcumin caused mitochondrial translocation of Bax, which was blocked by DIDS, suggesting a Bax-VDAC interaction.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	47-50
19693275-12	2009	Curcumin caused mitochondrial translocation of Bax, which was blocked by DIDS, suggesting a Bax-VDAC interaction.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	92-95
19693275-15	2009	CONCLUSIONS: Curcumin-induced fibroblast apoptosis is totally caspase-independent and relies on the mitochondrial formation of ROS and the subsequent nuclear translocation of AIF, which is released from a mitochondrial pore that involves VDAC, Bax and possibly ceramides.	Curcumin	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	244-247
19520742-8	2009	Tumor necrosis factor (TNF)-alpha/lipopolysaccharide (LPS)-induced VCAM-1 expression in HIMEC was suppressed by Akt small-interfering RNA, curcumin, and inhibitors of NF-kappaB (SN-50), p38 MAPK (SB-203580) and PI 3-kinase/Akt (LY-294002).	Curcumin	139-147	tumor necrosis factor	Homo sapiens	0-21
19520742-8	2009	Tumor necrosis factor (TNF)-alpha/lipopolysaccharide (LPS)-induced VCAM-1 expression in HIMEC was suppressed by Akt small-interfering RNA, curcumin, and inhibitors of NF-kappaB (SN-50), p38 MAPK (SB-203580) and PI 3-kinase/Akt (LY-294002).	Curcumin	139-147	tumor necrosis factor	Homo sapiens	23-33
19520742-8	2009	Tumor necrosis factor (TNF)-alpha/lipopolysaccharide (LPS)-induced VCAM-1 expression in HIMEC was suppressed by Akt small-interfering RNA, curcumin, and inhibitors of NF-kappaB (SN-50), p38 MAPK (SB-203580) and PI 3-kinase/Akt (LY-294002).	Curcumin	139-147	vascular cell adhesion molecule 1	Homo sapiens	67-73
19520742-10	2009	Curcumin inhibited Akt/MAPK/NF-kappaB activity and prevented nuclear translocation of the p65 NF-kappaB subunit following TNF-alpha/LPS.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	19-22
19520742-10	2009	Curcumin inhibited Akt/MAPK/NF-kappaB activity and prevented nuclear translocation of the p65 NF-kappaB subunit following TNF-alpha/LPS.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	28-37
19520742-10	2009	Curcumin inhibited Akt/MAPK/NF-kappaB activity and prevented nuclear translocation of the p65 NF-kappaB subunit following TNF-alpha/LPS.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	94-103
19520742-10	2009	Curcumin inhibited Akt/MAPK/NF-kappaB activity and prevented nuclear translocation of the p65 NF-kappaB subunit following TNF-alpha/LPS.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	122-131
19520742-11	2009	At physiological shear stress, curcumin attenuated leukocyte adhesion to TNF-alpha/LPS-activated HIMEC monolayers.	Curcumin	31-39	tumor necrosis factor	Homo sapiens	73-82
19520742-12	2009	In conclusion, curcumin inhibited the expression of VCAM-1 in HIMECs through blockade of Akt, p38 MAPK, and NF-kappaB.	Curcumin	15-23	vascular cell adhesion molecule 1	Homo sapiens	52-58
19520742-12	2009	In conclusion, curcumin inhibited the expression of VCAM-1 in HIMECs through blockade of Akt, p38 MAPK, and NF-kappaB.	Curcumin	15-23	AKT serine/threonine kinase 1	Homo sapiens	89-92
19520742-12	2009	In conclusion, curcumin inhibited the expression of VCAM-1 in HIMECs through blockade of Akt, p38 MAPK, and NF-kappaB.	Curcumin	15-23	nuclear factor kappa B subunit 1	Homo sapiens	108-117
19723081-2	2009	To bring insights into the anti-inflammatory mechanisms by which chemopreventive agents, such as curcumin, are able to counteract the action of inflammation mediators, such as tumor necrosis factor-alpha (TNF-alpha), we compared gene expression profiles in K562 cells treated with curcumin-TNF-alpha versus TNF-alpha alone.	Curcumin	97-105	tumor necrosis factor	Homo sapiens	176-203
19723081-2	2009	To bring insights into the anti-inflammatory mechanisms by which chemopreventive agents, such as curcumin, are able to counteract the action of inflammation mediators, such as tumor necrosis factor-alpha (TNF-alpha), we compared gene expression profiles in K562 cells treated with curcumin-TNF-alpha versus TNF-alpha alone.	Curcumin	97-105	tumor necrosis factor	Homo sapiens	205-214
19723081-2	2009	To bring insights into the anti-inflammatory mechanisms by which chemopreventive agents, such as curcumin, are able to counteract the action of inflammation mediators, such as tumor necrosis factor-alpha (TNF-alpha), we compared gene expression profiles in K562 cells treated with curcumin-TNF-alpha versus TNF-alpha alone.	Curcumin	97-105	tumor necrosis factor	Homo sapiens	290-299
19723081-2	2009	To bring insights into the anti-inflammatory mechanisms by which chemopreventive agents, such as curcumin, are able to counteract the action of inflammation mediators, such as tumor necrosis factor-alpha (TNF-alpha), we compared gene expression profiles in K562 cells treated with curcumin-TNF-alpha versus TNF-alpha alone.	Curcumin	97-105	tumor necrosis factor	Homo sapiens	290-299
19723087-2	2009	Curcumin has been shown to inhibit nuclear factor kappaB (NF-kappaB) activation at several steps in the NF-kappaB signaling pathways and thereby controls numerous NF-kappaB-regulated genes involved in various diseases.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	50-56
19723087-2	2009	Curcumin has been shown to inhibit nuclear factor kappaB (NF-kappaB) activation at several steps in the NF-kappaB signaling pathways and thereby controls numerous NF-kappaB-regulated genes involved in various diseases.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	58-67
19723087-2	2009	Curcumin has been shown to inhibit nuclear factor kappaB (NF-kappaB) activation at several steps in the NF-kappaB signaling pathways and thereby controls numerous NF-kappaB-regulated genes involved in various diseases.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	104-113
19723087-2	2009	Curcumin has been shown to inhibit nuclear factor kappaB (NF-kappaB) activation at several steps in the NF-kappaB signaling pathways and thereby controls numerous NF-kappaB-regulated genes involved in various diseases.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	61-67
19723087-3	2009	In the present study, we investigated the effect of curcumin pretreatment on 84 tumor necrosis factor-alpha (TNF-alpha)-activated genes of NF-kappaB pathways in K562 cells, using a real-time PCR array.	Curcumin	52-60	tumor necrosis factor	Homo sapiens	109-118
19723087-3	2009	In the present study, we investigated the effect of curcumin pretreatment on 84 tumor necrosis factor-alpha (TNF-alpha)-activated genes of NF-kappaB pathways in K562 cells, using a real-time PCR array.	Curcumin	52-60	nuclear factor kappa B subunit 1	Homo sapiens	139-148
19723087-6	2009	Taken together, we show that curcumin regulates an impressive number of NF-kappaB genes within the different NF-kappaB signaling pathways.	Curcumin	29-37	nuclear factor kappa B subunit 1	Homo sapiens	72-81
19723087-6	2009	Taken together, we show that curcumin regulates an impressive number of NF-kappaB genes within the different NF-kappaB signaling pathways.	Curcumin	29-37	nuclear factor kappa B subunit 1	Homo sapiens	109-118
19681867-3	2009	These paradoxical findings are extended in this issue: Kang and Chen demonstrate that while low-density lipoproteins (LDL) can activate HSCs, curcumin can inhibit this process by activation of PPARgamma, which not only represses gene expression of SREBP-2 and LDLR, but via induction of expression of SREBP-1c, restores the lipid storage capacity characteristic of quiescent HSCs, suggesting that curcumin may be of therapeutic usage in protecting against liver steatosis and fibrosis.	Curcumin	142-150	peroxisome proliferator activated receptor gamma	Homo sapiens	193-202
19681867-3	2009	These paradoxical findings are extended in this issue: Kang and Chen demonstrate that while low-density lipoproteins (LDL) can activate HSCs, curcumin can inhibit this process by activation of PPARgamma, which not only represses gene expression of SREBP-2 and LDLR, but via induction of expression of SREBP-1c, restores the lipid storage capacity characteristic of quiescent HSCs, suggesting that curcumin may be of therapeutic usage in protecting against liver steatosis and fibrosis.	Curcumin	142-150	sterol regulatory element binding transcription factor 2	Homo sapiens	248-255
19594758-0	2009	Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells.	Curcumin	0-8	low density lipoprotein receptor	Rattus norvegicus	34-72
19681867-3	2009	These paradoxical findings are extended in this issue: Kang and Chen demonstrate that while low-density lipoproteins (LDL) can activate HSCs, curcumin can inhibit this process by activation of PPARgamma, which not only represses gene expression of SREBP-2 and LDLR, but via induction of expression of SREBP-1c, restores the lipid storage capacity characteristic of quiescent HSCs, suggesting that curcumin may be of therapeutic usage in protecting against liver steatosis and fibrosis.	Curcumin	397-405	peroxisome proliferator activated receptor gamma	Homo sapiens	193-202
19594758-8	2009	Curcumin reduced the abundance of LDL receptor (LDLR) in activated HSCs, decreasing cellular cholesterol.	Curcumin	0-8	low density lipoprotein receptor	Rattus norvegicus	34-46
19594758-8	2009	Curcumin reduced the abundance of LDL receptor (LDLR) in activated HSCs, decreasing cellular cholesterol.	Curcumin	0-8	low density lipoprotein receptor	Rattus norvegicus	48-52
19594758-9	2009	Curcumin-dependent activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) differentially regulated the expression of the transcription factors, sterol regulatory element-binding proteins (SREBPs), in activated HSCs, resulting in the suppression of LDLR gene expression.	Curcumin	0-8	low density lipoprotein receptor	Rattus norvegicus	268-272
19956448-8	2009	Treatment with curcumin led to a dose-dependent decrease in the expression of NICD associated with the induction of cleaved poly ADP-ribose polymerase (PARP), the degradation of cyclin D1 and increase in cyclin-dependent kinase p21.	Curcumin	15-23	cyclin dependent kinase inhibitor 1A	Homo sapiens	228-231
19594758-10	2009	CONCLUSIONS AND IMPLICATIONS: Curcumin suppressed LDLR gene expression in activated HSCs in vitro by activating PPARgamma and differentially regulating gene expression of SREBPs, reducing cellular cholesterol and attenuating the stimulatory effects of LDL on HSC activation.	Curcumin	30-38	low density lipoprotein receptor	Rattus norvegicus	50-54
20141610-6	2009	Pre-treatment with the activator protein-1 (AP-1) inhibitor curcumin attenuated TNF-alpha induced transcription of the TGF-beta(1) gene.	Curcumin	60-68	tumor necrosis factor	Homo sapiens	80-89
20141610-6	2009	Pre-treatment with the activator protein-1 (AP-1) inhibitor curcumin attenuated TNF-alpha induced transcription of the TGF-beta(1) gene.	Curcumin	60-68	transforming growth factor beta 1	Homo sapiens	119-130
19671757-3	2009	Curcumin, a polyphenolic beta-diketone from tumeric with anti-carcinogenic and anti-inflammatory activities, was shown to suppress PGE(2) formation and to block the expression of COX-2 and of microsomal PGE(2) synthase-1.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	179-184
19956448-2	2009	We sought to evaluate the role of Notch1 in hepatocellular cancer (HCC), and evaluate the therapeutic efficacy of curcumin, a known Notch1 inhibitor.	Curcumin	114-122	notch receptor 1	Homo sapiens	132-138
19956448-8	2009	Treatment with curcumin led to a dose-dependent decrease in the expression of NICD associated with the induction of cleaved poly ADP-ribose polymerase (PARP), the degradation of cyclin D1 and increase in cyclin-dependent kinase p21.	Curcumin	15-23	poly(ADP-ribose) polymerase 1	Homo sapiens	124-150
19956448-8	2009	Treatment with curcumin led to a dose-dependent decrease in the expression of NICD associated with the induction of cleaved poly ADP-ribose polymerase (PARP), the degradation of cyclin D1 and increase in cyclin-dependent kinase p21.	Curcumin	15-23	poly(ADP-ribose) polymerase 1	Homo sapiens	152-156
19445907-0	2009	Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	42-46
19445907-12	2009	Curcumin high dose (100 mg/kg) upregulated Nrf2 and HO-1 in MCAO-affected brain tissue and reduced infarct volume (P&lt;0.05), brain water content (P&lt;0.05) and behavioral deficits (P&lt;0.05) caused by MCAO.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	43-47
19445907-14	2009	Curcumin protected the brain from damage caused by MCAO, this effect may be through upregulation of the transcription factor Nrf2 expression.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	125-129
19422808-1	2009	Docking analysis of curcumin (C1), demethoxycurcumin (C2) and bisdemethoxycurcumin (C3) with Bcl-2 illustrated that among the three curcuminoids, C2 binds more efficiently into its putative active site.	Curcumin	20-28	BCL2 apoptosis regulator	Homo sapiens	93-98
19956448-10	2009	Importantly, transfection of Notch1 small-interfering RNA (siRNA) into HCC cells resulted in cell growth inhibition and apoptosis, recapitulating the effects of curcumin.	Curcumin	161-169	notch receptor 1	Homo sapiens	29-35
19956448-12	2009	These results suggest for the first time that down-regulation of Notch1 signaling with curcumin is an attractive new therapeutic strategy for the treatment of patients with HCC.	Curcumin	87-95	notch receptor 1	Homo sapiens	65-71
19246153-2	2009	Here we show that the natural compound curcumin induces nuclear translocation of the heat shock transcription factor (HSF)-1, its binding to a heat shock regulatory element (HSE), and the subsequent activation of the hsp70 promoter through the extracellular regulated kinase (ERK)/mitogen activated protein (MAP) ERK (MEK) and c-jun N-terminal kinase (JNK) pathways, but not through p38.	Curcumin	39-47	mitogen-activated protein kinase kinase 7	Homo sapiens	318-321
19246153-2	2009	Here we show that the natural compound curcumin induces nuclear translocation of the heat shock transcription factor (HSF)-1, its binding to a heat shock regulatory element (HSE), and the subsequent activation of the hsp70 promoter through the extracellular regulated kinase (ERK)/mitogen activated protein (MAP) ERK (MEK) and c-jun N-terminal kinase (JNK) pathways, but not through p38.	Curcumin	39-47	mitogen-activated protein kinase 8	Homo sapiens	327-350
19246153-2	2009	Here we show that the natural compound curcumin induces nuclear translocation of the heat shock transcription factor (HSF)-1, its binding to a heat shock regulatory element (HSE), and the subsequent activation of the hsp70 promoter through the extracellular regulated kinase (ERK)/mitogen activated protein (MAP) ERK (MEK) and c-jun N-terminal kinase (JNK) pathways, but not through p38.	Curcumin	39-47	mitogen-activated protein kinase 8	Homo sapiens	352-355
19246153-2	2009	Here we show that the natural compound curcumin induces nuclear translocation of the heat shock transcription factor (HSF)-1, its binding to a heat shock regulatory element (HSE), and the subsequent activation of the hsp70 promoter through the extracellular regulated kinase (ERK)/mitogen activated protein (MAP) ERK (MEK) and c-jun N-terminal kinase (JNK) pathways, but not through p38.	Curcumin	39-47	mitogen-activated protein kinase 14	Homo sapiens	383-386
19246153-3	2009	We observe that curcumin activates hsp70A and hsp70B mRNA transcription, increases HSP protein expression but decreases the expression of Bag-1, a Hsp70 co-chaperone in K562 cells.	Curcumin	16-24	BAG cochaperone 1	Homo sapiens	138-143
19283527-0	2009	Curcumin sensitizes lung cancer cells to cisplatin-induced apoptosis through superoxide anion-mediated Bcl-2 degradation.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	103-108
19283527-2	2009	Curcumin was shown to induce superoxide anion generation, down-regulate anti-apoptotic Bcl-2 protein, and subsequently sensitize cells to cisplatin-induced apoptosis.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	87-92
19283527-3	2009	Co-treatment of the cells with curcumin and cisplatin resulted in increased apoptosis and reversal of Bcl-2-mediated cisplatin resistance.	Curcumin	31-39	BCL2 apoptosis regulator	Homo sapiens	102-107
19448398-2	2009	It has been previously demonstrated that curcumin is a potent inhibitor of EGF-receptor (EGFR) tyrosine kinase, but its inhibitive effect on p21-activated kinase 1 (PAK1), a downstream protein of EGFR, has not been defined.	Curcumin	41-49	epidermal growth factor receptor	Homo sapiens	75-87
19283527-4	2009	The mechanism by which curcumin down-regulates Bcl-2 and sensitizes cells to cisplatin-induced apoptosis involves proteasomal degradation of Bcl-2.	Curcumin	23-31	BCL2 apoptosis regulator	Homo sapiens	47-52
19448398-2	2009	It has been previously demonstrated that curcumin is a potent inhibitor of EGF-receptor (EGFR) tyrosine kinase, but its inhibitive effect on p21-activated kinase 1 (PAK1), a downstream protein of EGFR, has not been defined.	Curcumin	41-49	epidermal growth factor receptor	Homo sapiens	89-93
19448398-2	2009	It has been previously demonstrated that curcumin is a potent inhibitor of EGF-receptor (EGFR) tyrosine kinase, but its inhibitive effect on p21-activated kinase 1 (PAK1), a downstream protein of EGFR, has not been defined.	Curcumin	41-49	epidermal growth factor receptor	Homo sapiens	196-200
19448398-3	2009	In this paper we found that curcumin repressed the expression of HER2 and inhibited the kinase activity of PAK1 without affecting its expression.	Curcumin	28-36	erb-b2 receptor tyrosine kinase 2	Homo sapiens	65-69
19448398-4	2009	Silencing HER2 in gastric cancer cells showed that even if PAK1 activity was transiently strengthened by EGF, curcumin still had a strong inhibitive effect.	Curcumin	110-118	erb-b2 receptor tyrosine kinase 2	Homo sapiens	10-14
19283527-4	2009	The mechanism by which curcumin down-regulates Bcl-2 and sensitizes cells to cisplatin-induced apoptosis involves proteasomal degradation of Bcl-2.	Curcumin	23-31	BCL2 apoptosis regulator	Homo sapiens	141-146
19283527-5	2009	These findings indicate a novel pathway for curcumin regulation of Bcl-2, which could benefit the development of a cisplatin sensitizing agent.	Curcumin	44-52	BCL2 apoptosis regulator	Homo sapiens	67-72
19513510-9	2009	Curcumin also promoted the levels of Fas and FADD, Bax, cytochrome c release, but decreased the levels of Bcl-2 causing changes of DeltaPsim.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	106-111
19299451-9	2009	In addition, curcumin suppresses gene expression of Ob-R in HSCs, which requires the activation of endogenous peroxisome proliferator-activated receptor-gamma and de novo synthesis of glutathione.	Curcumin	13-21	peroxisome proliferator activated receptor gamma	Homo sapiens	110-158
19299451-10	2009	In conclusion, our results demonstrate that curcumin abrogates the stimulatory effect of leptin on HSC activation in vitro by reducing the phosphorylation level of Ob-R, stimulating peroxisome proliferator-activated receptor-gamma activity, and attenuating oxidative stress, leading to the suppression of Ob-R gene expression and interruption of leptin signaling.	Curcumin	44-52	peroxisome proliferator activated receptor gamma	Homo sapiens	182-230
19326431-0	2009	Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice.	Curcumin	26-34	phosphatase and tensin homolog	Mus musculus	103-107
19072988-10	2009	All anti-TNF therapeutics exhibited sustained release, with 10% of sTNFRII and anti-TNF antibody remaining after 7 days and 10% of curcumin remaining after 20 days.	Curcumin	131-139	tumor necrosis factor	Mus musculus	9-12
19359525-0	2009	The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists.	Curcumin	46-54	cannabinoid receptor 1	Homo sapiens	78-81
19320475-0	2009	Effective stabilization of curcumin by association to plasma proteins: human serum albumin and fibrinogen.	Curcumin	27-35	albumin	Homo sapiens	77-90
19152370-7	2009	Curcumin (1.25 approximately 10 microM) concentration-dependently suppressed TGF-beta1-induced alpha-SMA expression and collagen deposition in HSC-T6 cells, without cytotoxicity.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	77-86
19344704-4	2009	Whereas the expression of glutathione peroxidase (GPx), catalase, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and heme oxygenase-1 (HO-1) increased with curcumin concentration and also with increase in time of incubation, the expression of Mn- superoxide dismutase (Mn-SOD) showed concentration dependant repression upon treatment with curcumin.	Curcumin	148-156	catalase	Homo sapiens	56-64
19344704-4	2009	Whereas the expression of glutathione peroxidase (GPx), catalase, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and heme oxygenase-1 (HO-1) increased with curcumin concentration and also with increase in time of incubation, the expression of Mn- superoxide dismutase (Mn-SOD) showed concentration dependant repression upon treatment with curcumin.	Curcumin	148-156	superoxide dismutase 1	Homo sapiens	66-92
19344704-4	2009	Whereas the expression of glutathione peroxidase (GPx), catalase, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and heme oxygenase-1 (HO-1) increased with curcumin concentration and also with increase in time of incubation, the expression of Mn- superoxide dismutase (Mn-SOD) showed concentration dependant repression upon treatment with curcumin.	Curcumin	148-156	superoxide dismutase 1	Homo sapiens	94-103
19494316-6	2009	Thrombin-induced CTGF expression and CTGF-luciferase activity were inhibited by a protease-activated receptor 1 antagonist (SCH79797), the dominant-negative mutants (DNs) of ASK1 and JNK1/2, and an AP-1 inhibitor (curcumin).	Curcumin	214-222	coagulation factor II, thrombin	Homo sapiens	0-8
19494316-6	2009	Thrombin-induced CTGF expression and CTGF-luciferase activity were inhibited by a protease-activated receptor 1 antagonist (SCH79797), the dominant-negative mutants (DNs) of ASK1 and JNK1/2, and an AP-1 inhibitor (curcumin).	Curcumin	214-222	coagulation factor II thrombin receptor	Homo sapiens	82-111
19277688-5	2009	However, treatment of HaCaT with the TGF-beta1 inhibitor, curcumin, resulted in a concentration-dependant decrease in TGF-beta1 expression.	Curcumin	58-66	transforming growth factor beta 1	Homo sapiens	37-46
19277688-5	2009	However, treatment of HaCaT with the TGF-beta1 inhibitor, curcumin, resulted in a concentration-dependant decrease in TGF-beta1 expression.	Curcumin	58-66	transforming growth factor beta 1	Homo sapiens	118-127
19285535-9	2009	These results suggest that curcumin could possibly have a protective role in ulcerative colitis probably via regulation of oxidant/anti-oxidant balance and modulation of the release of some inflammatory endocoids, namely TNF-alpha and NO.	Curcumin	27-35	tumor necrosis factor	Mus musculus	221-230
19320475-0	2009	Effective stabilization of curcumin by association to plasma proteins: human serum albumin and fibrinogen.	Curcumin	27-35	fibrinogen beta chain	Homo sapiens	95-105
19320475-8	2009	In the presence of both transferrin and IgG, curcumin continues to undergo rapid hydrolysis but this reaction is suppressed by the presence of either HSA or fibrinogen with an impressive yield of approximately 95%.	Curcumin	45-53	transferrin	Homo sapiens	24-35
19320475-8	2009	In the presence of both transferrin and IgG, curcumin continues to undergo rapid hydrolysis but this reaction is suppressed by the presence of either HSA or fibrinogen with an impressive yield of approximately 95%.	Curcumin	45-53	fibrinogen beta chain	Homo sapiens	157-167
19320475-9	2009	Furthermore, the binding constants of curcumin to HSA and fibrinogen are on the order of 10(4) and 10(5) M(-1), respectively.	Curcumin	38-46	fibrinogen beta chain	Homo sapiens	58-68
19320475-12	2009	Therefore, strong interactions with HSA and fibrinogen inhibit hydrolysis of curcumin and in turn lead to effective suppression of degradation.	Curcumin	77-85	fibrinogen beta chain	Homo sapiens	44-54
19401701-0	2009	Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells.	Curcumin	26-34	checkpoint kinase 1	Homo sapiens	18-22
19189304-8	2009	The involvement of nuclear factor-kappaB (NF-kappaB) was demonstrated since the anti-inflammatory agent curcumin blocked VIP effects on the above biomarkers in both cell lines.	Curcumin	104-112	nuclear factor kappa B subunit 1	Homo sapiens	19-40
19189304-8	2009	The involvement of nuclear factor-kappaB (NF-kappaB) was demonstrated since the anti-inflammatory agent curcumin blocked VIP effects on the above biomarkers in both cell lines.	Curcumin	104-112	nuclear factor kappa B subunit 1	Homo sapiens	42-51
19189304-8	2009	The involvement of nuclear factor-kappaB (NF-kappaB) was demonstrated since the anti-inflammatory agent curcumin blocked VIP effects on the above biomarkers in both cell lines.	Curcumin	104-112	vasoactive intestinal peptide	Homo sapiens	121-124
19401701-4	2009	Immunoblot studies revealed increased phosphorylation of H2A.X at Ser-139 and Chk1 at Ser-280 and a decrease in DNA polymerase-beta level in curcumin-treated cells.	Curcumin	141-149	checkpoint kinase 1	Homo sapiens	78-82
19401701-9	2009	Further, curcumin treatment caused significant cleavage of caspase-3 and PARP in BxPC-3 but not in HPDE-6 cells.	Curcumin	9-17	caspase 3	Homo sapiens	59-68
19401701-9	2009	Further, curcumin treatment caused significant cleavage of caspase-3 and PARP in BxPC-3 but not in HPDE-6 cells.	Curcumin	9-17	poly(ADP-ribose) polymerase 1	Homo sapiens	73-77
18710704-8	2009	Curcumin (NF-kappaB inhibitor) significantly inhibited all these IL-1 beta-mediated effects.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	10-19
19401701-10	2009	Silencing ATM/Chk1 expression by transfecting BxPC-3 cells with ATM or Chk1-specific SiRNA blocked the phosphorylation of ATM, Chk1 and Cdc25C and protected the cells from curcumin-mediated G2/M arrest and apoptosis.	Curcumin	172-180	checkpoint kinase 1	Homo sapiens	14-18
19401701-10	2009	Silencing ATM/Chk1 expression by transfecting BxPC-3 cells with ATM or Chk1-specific SiRNA blocked the phosphorylation of ATM, Chk1 and Cdc25C and protected the cells from curcumin-mediated G2/M arrest and apoptosis.	Curcumin	172-180	checkpoint kinase 1	Homo sapiens	71-75
19401701-10	2009	Silencing ATM/Chk1 expression by transfecting BxPC-3 cells with ATM or Chk1-specific SiRNA blocked the phosphorylation of ATM, Chk1 and Cdc25C and protected the cells from curcumin-mediated G2/M arrest and apoptosis.	Curcumin	172-180	checkpoint kinase 1	Homo sapiens	71-75
19401701-11	2009	This study reflects the critical role of ATM/Chk1 in curcumin-mediated G2/M cell cycle arrest and apoptosis in pancreatic cancer cells.	Curcumin	53-61	checkpoint kinase 1	Homo sapiens	45-49
19645775-3	2009	The antitumor effects of curcumin could be due in part to the inactivation of NF-kappaB.	Curcumin	25-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	78-87
19645775-5	2009	In this study, we investigated whether the inactivation of NF-kappaB by curcumin would enhance the efficacy of paclitaxel for inhibiting breast cancer growth in vitro and in vivo.	Curcumin	72-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	59-68
19645775-6	2009	We confirmed that curcumin inhibited paclitaxel-induced activation of NF-kappaB and potentiated the growth inhibitory effect of paclitaxel in MDA-MB-231 breast cancer cells.	Curcumin	18-26	nuclear factor kappa B subunit 1	Homo sapiens	70-79
18555241-0	2009	Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression.	Curcumin	0-8	fibronectin 1	Homo sapiens	113-124
18555241-9	2009	Curcumin stimulated caspase-3 and caspase-9 expression while inhibiting extracellular signal-regulated kinase 1 (ERK 1), ERK 2, and nuclear factor kappa B (NF-kappaB), suggesting regulation of leiomyocyte apoptosis.	Curcumin	0-8	caspase 3	Homo sapiens	20-29
18555241-9	2009	Curcumin stimulated caspase-3 and caspase-9 expression while inhibiting extracellular signal-regulated kinase 1 (ERK 1), ERK 2, and nuclear factor kappa B (NF-kappaB), suggesting regulation of leiomyocyte apoptosis.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	72-111
18555241-9	2009	Curcumin stimulated caspase-3 and caspase-9 expression while inhibiting extracellular signal-regulated kinase 1 (ERK 1), ERK 2, and nuclear factor kappa B (NF-kappaB), suggesting regulation of leiomyocyte apoptosis.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	113-118
18555241-9	2009	Curcumin stimulated caspase-3 and caspase-9 expression while inhibiting extracellular signal-regulated kinase 1 (ERK 1), ERK 2, and nuclear factor kappa B (NF-kappaB), suggesting regulation of leiomyocyte apoptosis.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	121-126
18555241-9	2009	Curcumin stimulated caspase-3 and caspase-9 expression while inhibiting extracellular signal-regulated kinase 1 (ERK 1), ERK 2, and nuclear factor kappa B (NF-kappaB), suggesting regulation of leiomyocyte apoptosis.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	132-154
18555241-9	2009	Curcumin stimulated caspase-3 and caspase-9 expression while inhibiting extracellular signal-regulated kinase 1 (ERK 1), ERK 2, and nuclear factor kappa B (NF-kappaB), suggesting regulation of leiomyocyte apoptosis.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	156-165
19225048-2	2009	In hepatic cells, curcumin is shown to antagonize TNF-alpha-elicited NF-kappaB activation.	Curcumin	18-26	tumor necrosis factor	Rattus norvegicus	50-59
19225048-13	2009	Studies in mesangial cells were carried out to further establish that the anti-inflammatory effect of curcumin in vivo was mediated essentially by antagonizing TNF-alpha.	Curcumin	102-110	tumor necrosis factor	Rattus norvegicus	160-169
19225048-14	2009	Curcumin dose dependently antagonized the TNF-alpha-mediated decrease in PPARgamma and blocked transactivation of NF-kappaB and repression of PPARgamma, indicating that the anti-inflamatory property of curcumin may be responsible for alleviating CRF in Nx animals.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	42-51
19225048-14	2009	Curcumin dose dependently antagonized the TNF-alpha-mediated decrease in PPARgamma and blocked transactivation of NF-kappaB and repression of PPARgamma, indicating that the anti-inflamatory property of curcumin may be responsible for alleviating CRF in Nx animals.	Curcumin	202-210	tumor necrosis factor	Rattus norvegicus	42-51
18555241-11	2009	CONCLUSION(S): Our findings demonstrate that curcumin inhibited uterine leiomyoma cell proliferation via regulation of the apoptotic pathway, and inhibited production of the ECM component fibronectin.	Curcumin	45-53	fibronectin 1	Homo sapiens	188-199
19539560-9	2009	These findings indicated that curcumin amelioration EAE was, to a large extent, due to inhibit differentiation and development of Th17 cells depends on down-regulating expression of IL-6, IL-21, RORgammat signaling and inhibition STAT3-phosphorylation, suggests it is useful in the treatment of MS and other Th17 cell-mediated inflammatory diseases.	Curcumin	30-38	interleukin 6	Rattus norvegicus	182-186
19539560-9	2009	These findings indicated that curcumin amelioration EAE was, to a large extent, due to inhibit differentiation and development of Th17 cells depends on down-regulating expression of IL-6, IL-21, RORgammat signaling and inhibition STAT3-phosphorylation, suggests it is useful in the treatment of MS and other Th17 cell-mediated inflammatory diseases.	Curcumin	30-38	interleukin 21	Rattus norvegicus	188-193
18555241-10	2009	Finally, curcumin inhibited expression of fibronectin in leiomyoma cells.	Curcumin	9-17	fibronectin 1	Homo sapiens	42-53
18710704-8	2009	Curcumin (NF-kappaB inhibitor) significantly inhibited all these IL-1 beta-mediated effects.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	65-74
19191010-5	2009	Curcumin mediated apoptosis in these cells appears to be due to upregulation of proapoptotic Bax, AIF, release of cytochrome c and down regulation of antiapoptotic Bcl-2, Bcl-XL in HeLa and SiHa.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	93-96
19393026-9	2009	Inhibition of AP-1 with curcumin also inhibited 14-3-3gamma up-regulation indicating that ischemia-induced up-regulation of 14-3-3gamma in astrocyte involves activation of the JNK/p-c-Jun/AP-1 pathway.	Curcumin	24-32	mitogen-activated protein kinase 8	Homo sapiens	176-179
19191010-5	2009	Curcumin mediated apoptosis in these cells appears to be due to upregulation of proapoptotic Bax, AIF, release of cytochrome c and down regulation of antiapoptotic Bcl-2, Bcl-XL in HeLa and SiHa.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	114-126
19191010-5	2009	Curcumin mediated apoptosis in these cells appears to be due to upregulation of proapoptotic Bax, AIF, release of cytochrome c and down regulation of antiapoptotic Bcl-2, Bcl-XL in HeLa and SiHa.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	164-169
19191010-5	2009	Curcumin mediated apoptosis in these cells appears to be due to upregulation of proapoptotic Bax, AIF, release of cytochrome c and down regulation of antiapoptotic Bcl-2, Bcl-XL in HeLa and SiHa.	Curcumin	0-8	BCL2 like 1	Homo sapiens	171-177
19191010-6	2009	This was accompanied by an increase in caspase-3 and -9 activity, suggesting the role of mitochondria in curcumin mediated apoptotic cell death.	Curcumin	105-113	caspase 3	Homo sapiens	39-55
19191010-7	2009	Curcumin acts as an anti-inflammatory and anti-proliferative agent by causing down regulation of COX-2, iNOS and cyclin D1 in all the three cell lines but to different extent.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
19288022-8	2009	Curcumin increased the protein expressions of p21 and Bax, but decreased the protein expression of p53 and Bcl-2 in MDA-MB-231 cells.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	107-112
19076306-7	2009	In most of the regions examined, histone H3 acetylation peaked 24 h after UVR and then returned to baseline levels by 72 h. The induction of ATF3, COX2 and MKP1 was blocked in the presence of curcumin at doses that decrease in vivo histone H3 acetylation but not at lower doses that do not affect acetylation levels.	Curcumin	192-200	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-151
19076306-7	2009	In most of the regions examined, histone H3 acetylation peaked 24 h after UVR and then returned to baseline levels by 72 h. The induction of ATF3, COX2 and MKP1 was blocked in the presence of curcumin at doses that decrease in vivo histone H3 acetylation but not at lower doses that do not affect acetylation levels.	Curcumin	192-200	dual specificity phosphatase 1	Homo sapiens	156-160
19548565-5	2009	FRAP: Used 1.0 mmol/L FeSO4 as the reference standard, quercetin, curcumin and Trolox equivalent molar about 5.73, 1.18 and 2.09.	Curcumin	66-74	mechanistic target of rapamycin kinase	Homo sapiens	0-4
19771847-3	2009	RESULTS: The suppressive effect of curcumin was shown as a dose dependent and a time dependent manner,and the IC50 was 22.48 micromol/L 40 micromol/L curcumin inhibited the expression of p-ERK, p-NF-kappaB and p-p38, but not p-JNK.	Curcumin	35-43	mitogen-activated protein kinase 8	Homo sapiens	227-230
19771847-3	2009	RESULTS: The suppressive effect of curcumin was shown as a dose dependent and a time dependent manner,and the IC50 was 22.48 micromol/L 40 micromol/L curcumin inhibited the expression of p-ERK, p-NF-kappaB and p-p38, but not p-JNK.	Curcumin	150-158	mitogen-activated protein kinase 8	Homo sapiens	227-230
19161989-4	2009	Curcumin increased NCAM PSA expression in cultured neuro-2A neuroblastoma cells and this was inversely related to PKCdelta protein expression.	Curcumin	0-8	neural cell adhesion molecule 1	Mus musculus	19-23
22009832-8	2009	This curcumin-induced apoptosis in U2OS cells was accompanied by up-regulation of Bax, Bak, and p-Bad and down-regulation of Bcl-2, but no effect on the levels of Bcl-X(L) or Bad proteins was noted.	Curcumin	5-13	BCL2 associated X, apoptosis regulator	Homo sapiens	82-85
22009832-8	2009	This curcumin-induced apoptosis in U2OS cells was accompanied by up-regulation of Bax, Bak, and p-Bad and down-regulation of Bcl-2, but no effect on the levels of Bcl-X(L) or Bad proteins was noted.	Curcumin	5-13	BCL2 apoptosis regulator	Homo sapiens	125-130
22009832-9	2009	Moreover, curcumin treatment resulted in a significant reduction of mitochondrial membrane potential and increase in the concentrations of mitochondrial cytochrome C and caspase-3.	Curcumin	10-18	cytochrome c, somatic	Homo sapiens	153-165
22009832-9	2009	Moreover, curcumin treatment resulted in a significant reduction of mitochondrial membrane potential and increase in the concentrations of mitochondrial cytochrome C and caspase-3.	Curcumin	10-18	caspase 3	Homo sapiens	170-179
19426594-1	2009	AIM: To study the effects of curcumin on TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice.	Curcumin	29-37	tumor necrosis factor	Mus musculus	41-50
19426594-6	2009	Compared with sham operation group, TNF-alpha and TGF-beta1 in serum and lung tissue increased significantly(P&lt;0.01), but decreased in different degrees after treated with curcumin(P&lt;0.05).	Curcumin	175-183	tumor necrosis factor	Mus musculus	36-45
19426594-7	2009	CONCLUSION: Curcumin can decrease the level of TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice and have the anti-fibrosis role by deregulating cytokine level.	Curcumin	12-20	tumor necrosis factor	Mus musculus	47-56
19288022-0	2009	Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-kappaBp65 expression in breast cancer MDA-MB-231 cells.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	64-67
19288022-0	2009	Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-kappaBp65 expression in breast cancer MDA-MB-231 cells.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	71-76
19288022-8	2009	Curcumin increased the protein expressions of p21 and Bax, but decreased the protein expression of p53 and Bcl-2 in MDA-MB-231 cells.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	54-57
19288022-8	2009	Curcumin increased the protein expressions of p21 and Bax, but decreased the protein expression of p53 and Bcl-2 in MDA-MB-231 cells.	Curcumin	0-8	tumor protein p53	Homo sapiens	99-102
19288022-9	2009	Our results show that one molecular mechanism of curcumin inhibits the proliferation of MDA-MB-231 cells either through up-regulating p21 expression and then inducing apoptosis, or through up-regulating the Bax to Bcl-2 ratio and then inducing apoptosis.	Curcumin	49-57	BCL2 associated X, apoptosis regulator	Homo sapiens	207-210
19288022-9	2009	Our results show that one molecular mechanism of curcumin inhibits the proliferation of MDA-MB-231 cells either through up-regulating p21 expression and then inducing apoptosis, or through up-regulating the Bax to Bcl-2 ratio and then inducing apoptosis.	Curcumin	49-57	BCL2 apoptosis regulator	Homo sapiens	214-219
19188055-2	2009	Western blot analysis of mouse macrophage cell line RAW 264.7 activated with lipopolysaccharide showed that bisdemethoxycurcumin inhibited inducible nitric oxide synthase (iNOS) production significantly but had no effect on tumor necrosis factor-alpha (TNF-alpha) production, whereas curcumin showed stronger suppression of iNOS protein production and inhibited TNF-alpha protein production significantly.	Curcumin	120-128	nitric oxide synthase 2, inducible	Mus musculus	172-176
19373661-5	2009	Furthermore, rapamycin and curcumin increased caspase 9, 3 and 7 activity, decreased anti-apoptotic bcl-2 levels, and increased the pro-apoptotic protein Bax.	Curcumin	27-35	BCL2 apoptosis regulator	Homo sapiens	100-105
19373661-5	2009	Furthermore, rapamycin and curcumin increased caspase 9, 3 and 7 activity, decreased anti-apoptotic bcl-2 levels, and increased the pro-apoptotic protein Bax.	Curcumin	27-35	BCL2 associated X, apoptosis regulator	Homo sapiens	154-157
19372569-4	2009	Curcumin also potentiated the apoptotic effects of thalidomide and bortezomib by down-regulating the constitutive activation of NF-kappaB and Akt, and this correlated with the suppression of NF-kappaB-regulated gene products, including cyclin D1, Bcl-xL, Bcl-2, TRAF1, cIAP-1, XIAP, survivin, and vascular endothelial growth factor.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	142-145
19372569-4	2009	Curcumin also potentiated the apoptotic effects of thalidomide and bortezomib by down-regulating the constitutive activation of NF-kappaB and Akt, and this correlated with the suppression of NF-kappaB-regulated gene products, including cyclin D1, Bcl-xL, Bcl-2, TRAF1, cIAP-1, XIAP, survivin, and vascular endothelial growth factor.	Curcumin	0-8	BCL2 like 1	Homo sapiens	247-253
19372569-4	2009	Curcumin also potentiated the apoptotic effects of thalidomide and bortezomib by down-regulating the constitutive activation of NF-kappaB and Akt, and this correlated with the suppression of NF-kappaB-regulated gene products, including cyclin D1, Bcl-xL, Bcl-2, TRAF1, cIAP-1, XIAP, survivin, and vascular endothelial growth factor.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	255-260
19372569-4	2009	Curcumin also potentiated the apoptotic effects of thalidomide and bortezomib by down-regulating the constitutive activation of NF-kappaB and Akt, and this correlated with the suppression of NF-kappaB-regulated gene products, including cyclin D1, Bcl-xL, Bcl-2, TRAF1, cIAP-1, XIAP, survivin, and vascular endothelial growth factor.	Curcumin	0-8	TNF receptor associated factor 1	Homo sapiens	262-267
19372569-4	2009	Curcumin also potentiated the apoptotic effects of thalidomide and bortezomib by down-regulating the constitutive activation of NF-kappaB and Akt, and this correlated with the suppression of NF-kappaB-regulated gene products, including cyclin D1, Bcl-xL, Bcl-2, TRAF1, cIAP-1, XIAP, survivin, and vascular endothelial growth factor.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	297-331
19188055-2	2009	Western blot analysis of mouse macrophage cell line RAW 264.7 activated with lipopolysaccharide showed that bisdemethoxycurcumin inhibited inducible nitric oxide synthase (iNOS) production significantly but had no effect on tumor necrosis factor-alpha (TNF-alpha) production, whereas curcumin showed stronger suppression of iNOS protein production and inhibited TNF-alpha protein production significantly.	Curcumin	120-128	tumor necrosis factor	Mus musculus	224-251
19188055-2	2009	Western blot analysis of mouse macrophage cell line RAW 264.7 activated with lipopolysaccharide showed that bisdemethoxycurcumin inhibited inducible nitric oxide synthase (iNOS) production significantly but had no effect on tumor necrosis factor-alpha (TNF-alpha) production, whereas curcumin showed stronger suppression of iNOS protein production and inhibited TNF-alpha protein production significantly.	Curcumin	120-128	tumor necrosis factor	Mus musculus	253-262
19188055-2	2009	Western blot analysis of mouse macrophage cell line RAW 264.7 activated with lipopolysaccharide showed that bisdemethoxycurcumin inhibited inducible nitric oxide synthase (iNOS) production significantly but had no effect on tumor necrosis factor-alpha (TNF-alpha) production, whereas curcumin showed stronger suppression of iNOS protein production and inhibited TNF-alpha protein production significantly.	Curcumin	120-128	nitric oxide synthase 2, inducible	Mus musculus	324-328
19188055-2	2009	Western blot analysis of mouse macrophage cell line RAW 264.7 activated with lipopolysaccharide showed that bisdemethoxycurcumin inhibited inducible nitric oxide synthase (iNOS) production significantly but had no effect on tumor necrosis factor-alpha (TNF-alpha) production, whereas curcumin showed stronger suppression of iNOS protein production and inhibited TNF-alpha protein production significantly.	Curcumin	120-128	tumor necrosis factor	Mus musculus	362-371
19188055-4	2009	Reverse-transcriptase polymerase chain reaction (RT-PCR) analysis showed that both curcuminoids inhibited the induction of iNOS dose-dependently at the transcriptional level and curcumin also appeared to inhibit the induction of TNF-alpha at post-transcriptional level.	Curcumin	83-91	nitric oxide synthase 2, inducible	Mus musculus	123-127
19188055-4	2009	Reverse-transcriptase polymerase chain reaction (RT-PCR) analysis showed that both curcuminoids inhibited the induction of iNOS dose-dependently at the transcriptional level and curcumin also appeared to inhibit the induction of TNF-alpha at post-transcriptional level.	Curcumin	83-91	tumor necrosis factor	Mus musculus	229-238
19326074-6	2009	Biochemical analysis showed that the expression of Bax, Bid and cytochrome C were up-regulated, while the expression of oncogene c-Myc was down regulated after curcumin treatment.	Curcumin	160-168	BCL2 associated X, apoptosis regulator	Homo sapiens	51-54
19350453-2	2009	Curcumin, a promising chemotherapeutic agent, inhibits human GSTA1-1, GSTM1-1, and GSTP1-1 isoenzymes.	Curcumin	0-8	glutathione S-transferase mu 1	Homo sapiens	70-77
19350453-4	2009	Most of the 34 curcumin analogues showed less potent inhibitory activities towards GSTA1-1, GSTM1-1, and GSTP1-1 than the parent curcumin.	Curcumin	15-23	glutathione S-transferase mu 1	Homo sapiens	92-99
19326074-6	2009	Biochemical analysis showed that the expression of Bax, Bid and cytochrome C were up-regulated, while the expression of oncogene c-Myc was down regulated after curcumin treatment.	Curcumin	160-168	BH3 interacting domain death agonist	Homo sapiens	56-59
18937212-2	2009	Several inhibitors of NF-kappaB, like caffeic acid, captopril, curcumin, pyrrolidine dithiocarbamate, resveratrol, silymarin and thalidomide, have demonstrated antinecrotic, anticholestatic, antifibrotic and anticancer activities in the liver.	Curcumin	63-71	nuclear factor kappa B subunit 1	Homo sapiens	22-31
19294764-5	2009	RESULTS: Treatment with 10-80 micromol/L curcumin induced typical features of apoptosis and activated the caspase-3 in HT-29 cells.	Curcumin	41-49	caspase 3	Homo sapiens	106-115
19294764-7	2009	CONCLUSION: Curcumin can induce apoptosis of HT-29 cells and down-regulate the expression of PPARdelta, 14-3-3epsilon and VEGF in HT-29.	Curcumin	12-20	vascular endothelial growth factor A	Homo sapiens	122-126
19121385-6	2009	When tested on retina-derived cell lines (661W and ARPE-19), pretreatment of curcumin protected these cells from H(2)O(2)-induced cell death by up-regulating cellular protective enzymes, such as HO-1, thioredoxin.	Curcumin	77-85	thioredoxin 1	Rattus norvegicus	201-212
19121385-7	2009	Since, curcumin with its pleiotropic activities can modulate the expression and activation of many cellular regulatory proteins such as NF-kappaB, AKT, NRF2, and growth factors, which in turn inhibit cellular inflammatory responses and protect cells; we speculate that curcumin would be an effective nutraceutical compound for preventive and augmentative therapy of AMD.	Curcumin	7-15	AKT serine/threonine kinase 1	Rattus norvegicus	147-150
19121385-7	2009	Since, curcumin with its pleiotropic activities can modulate the expression and activation of many cellular regulatory proteins such as NF-kappaB, AKT, NRF2, and growth factors, which in turn inhibit cellular inflammatory responses and protect cells; we speculate that curcumin would be an effective nutraceutical compound for preventive and augmentative therapy of AMD.	Curcumin	7-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	152-156
19196508-0	2009	Wilms" tumour gene 1 (WT1) as a target in curcumin treatment of pancreatic cancer cells.	Curcumin	42-50	WT1 transcription factor	Homo sapiens	0-20
19196508-0	2009	Wilms" tumour gene 1 (WT1) as a target in curcumin treatment of pancreatic cancer cells.	Curcumin	42-50	WT1 transcription factor	Homo sapiens	22-25
19196508-3	2009	In this context, the purpose of this study was to determine the role of WT1 in a curcumin-treated pancreatic cancer cell line.	Curcumin	81-89	WT1 transcription factor	Homo sapiens	72-75
19196508-4	2009	To study the effect of curcumin on the expression of WT1, we incubated the pancreatic cancer cell line PANC-1 with different amounts of curcumin.	Curcumin	23-31	WT1 transcription factor	Homo sapiens	53-56
19196508-7	2009	The expression of WT1 on mRNA and protein level was significantly down-regulated in a concentration-dependent manner after treatment with curcumin.	Curcumin	138-146	WT1 transcription factor	Homo sapiens	18-21
19196508-8	2009	The WT1 mRNA levels were decreased by 20%, 25%, 40%, 78% and 88% in response to 10, 20, 30, 40 and 50 microM curcumin.	Curcumin	109-117	WT1 transcription factor	Homo sapiens	4-7
19196508-10	2009	Combined treatment with curcumin and siRNA targeting WT1 resulted in a significant inhibition of cell proliferation compared to curcumin-treated cells alone.	Curcumin	128-136	WT1 transcription factor	Homo sapiens	53-56
19196508-12	2009	Targeting WT1 gene expression with siRNA may enhance the efficacy of curcumin to inhibit cell proliferation.	Curcumin	69-77	WT1 transcription factor	Homo sapiens	10-13
19101502-5	2009	To explore the underlying cellular and molecular mechanisms, we found that curcumin was capable of restoring caveolin-1 expression which was reduced by Chol:MbetaCD treatment.	Curcumin	75-83	caveolin 1	Rattus norvegicus	109-119
19212627-5	2009	To develop a strategy of inducing apoptosis of skin cancer cells, the current study was performed to investigate the apoptotic pathway, especially focused on Bcl2 family proteins, in curcumin or UVB-treated basal cell carcinoma cell lines.	Curcumin	183-191	BCL2 apoptosis regulator	Homo sapiens	158-162
19228728-7	2009	RESULTS: Curcumin induced apoptosis in CLL B cells in a dose-dependent (5-20 micromol/L) manner and inhibited constitutively active prosurvival pathways, including signal transducers and activators of transcription 3 (STAT3), AKT, and nuclear factor kappaB.	Curcumin	9-17	signal transducer and activator of transcription 3	Homo sapiens	164-216
19228728-7	2009	RESULTS: Curcumin induced apoptosis in CLL B cells in a dose-dependent (5-20 micromol/L) manner and inhibited constitutively active prosurvival pathways, including signal transducers and activators of transcription 3 (STAT3), AKT, and nuclear factor kappaB.	Curcumin	9-17	signal transducer and activator of transcription 3	Homo sapiens	218-223
19228728-7	2009	RESULTS: Curcumin induced apoptosis in CLL B cells in a dose-dependent (5-20 micromol/L) manner and inhibited constitutively active prosurvival pathways, including signal transducers and activators of transcription 3 (STAT3), AKT, and nuclear factor kappaB.	Curcumin	9-17	AKT serine/threonine kinase 1	Homo sapiens	226-229
19121625-3	2009	The incubation of RAW264.7 cells with curcumin dose-dependently inhibited the stimulatory responses of macrophage triggered by lipopolysaccharide; the enhanced secretion of inflammatory cytokines such as TNF-alpha and IL-1beta and the up-regulated expression of surface antigens like CD14 and CD40.	Curcumin	38-46	tumor necrosis factor	Mus musculus	204-213
19121625-3	2009	The incubation of RAW264.7 cells with curcumin dose-dependently inhibited the stimulatory responses of macrophage triggered by lipopolysaccharide; the enhanced secretion of inflammatory cytokines such as TNF-alpha and IL-1beta and the up-regulated expression of surface antigens like CD14 and CD40.	Curcumin	38-46	interleukin 1 beta	Mus musculus	218-226
19101502-7	2009	In addition, curcumin was able to reverse cell cycle progression induced by Chol:MbetaCD, which was further supported by its down-regulation of cyclinD1 and E2F promoter activities in the presence of Chol:MbetaCD.	Curcumin	13-21	cyclin D1	Rattus norvegicus	144-152
19121625-4	2009	Curcumin alone, however, was able to increase the basal level of TNF-alpha secretion and elevated markedly the expression of CD14 and slightly CD40.	Curcumin	0-8	tumor necrosis factor	Mus musculus	65-74
19101502-8	2009	Taking together, our data suggest curcumin inhibits Chol:MbetaCD-induced VSMCs proliferation via restoring caveolin-1 expression that leads to the suppression of over-activated ERK signaling and causes cell cycle arrest at G1/S phase.	Curcumin	34-42	caveolin 1	Rattus norvegicus	107-117
19101502-8	2009	Taking together, our data suggest curcumin inhibits Chol:MbetaCD-induced VSMCs proliferation via restoring caveolin-1 expression that leads to the suppression of over-activated ERK signaling and causes cell cycle arrest at G1/S phase.	Curcumin	34-42	Eph receptor B1	Rattus norvegicus	177-180
19074641-0	2009	Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB.	Curcumin	10-18	interleukin 6	Homo sapiens	54-58
19075017-0	2009	Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase Cdelta-STAT1 signaling pathway in interferon-gamma-stimulated murine dendritic cells.	Curcumin	0-8	interferon gamma	Mus musculus	153-169
19075017-5	2009	In addition, we demonstrate that curcumin, an active component of turmeric, significantly inhibited the induction of IDO expression and activity by IFNgamma.	Curcumin	33-41	interferon gamma	Mus musculus	148-156
19074641-6	2009	Curcumin, as well as inhibitors of NF-kappaB (SN-50), PKC (chelerythrine), and p44/42 MAPK (PD-098059) abolished the acid-induced expression of IL-6 and IL-8.	Curcumin	0-8	interleukin 6	Homo sapiens	144-148
19074641-6	2009	Curcumin, as well as inhibitors of NF-kappaB (SN-50), PKC (chelerythrine), and p44/42 MAPK (PD-098059) abolished the acid-induced expression of IL-6 and IL-8.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	153-157
19074641-9	2009	Together, these data demonstrate that 1) acid is a potent inducer of IL-6 and IL-8 production in HET-1A cells; 2) MAPK and PKC signaling play a key regulatory role in acid-mediated IL-6 and IL-8 expression via NF-kappaB activation; and 3) the anti-inflammatory plant compound curcumin inhibits esophageal activation in response to acid.	Curcumin	276-284	interleukin 6	Homo sapiens	181-185
19074641-9	2009	Together, these data demonstrate that 1) acid is a potent inducer of IL-6 and IL-8 production in HET-1A cells; 2) MAPK and PKC signaling play a key regulatory role in acid-mediated IL-6 and IL-8 expression via NF-kappaB activation; and 3) the anti-inflammatory plant compound curcumin inhibits esophageal activation in response to acid.	Curcumin	276-284	C-X-C motif chemokine ligand 8	Homo sapiens	190-194
19074641-9	2009	Together, these data demonstrate that 1) acid is a potent inducer of IL-6 and IL-8 production in HET-1A cells; 2) MAPK and PKC signaling play a key regulatory role in acid-mediated IL-6 and IL-8 expression via NF-kappaB activation; and 3) the anti-inflammatory plant compound curcumin inhibits esophageal activation in response to acid.	Curcumin	276-284	nuclear factor kappa B subunit 1	Homo sapiens	210-219
18976114-0	2009	Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	32-41
19250217-6	2009	Furthermore, curcumin or, more potently, the isoxazole analogue, produced early reductions in the amounts of relevant gene transcripts that were diverse (i.e., they were relative to Bcl-2 and Bcl-X(L) in MCF-7 and the inhibitory of apoptosis proteins and COX-2 in MCF-7R) in the two cell lines.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	182-187
19250217-6	2009	Furthermore, curcumin or, more potently, the isoxazole analogue, produced early reductions in the amounts of relevant gene transcripts that were diverse (i.e., they were relative to Bcl-2 and Bcl-X(L) in MCF-7 and the inhibitory of apoptosis proteins and COX-2 in MCF-7R) in the two cell lines.	Curcumin	13-21	BCL2 like 1	Homo sapiens	192-200
19250217-6	2009	Furthermore, curcumin or, more potently, the isoxazole analogue, produced early reductions in the amounts of relevant gene transcripts that were diverse (i.e., they were relative to Bcl-2 and Bcl-X(L) in MCF-7 and the inhibitory of apoptosis proteins and COX-2 in MCF-7R) in the two cell lines.	Curcumin	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	255-260
18976114-0	2009	Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats.	Curcumin	0-8	interleukin 6	Rattus norvegicus	43-47
18976114-0	2009	Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats.	Curcumin	0-8	mast cell protease 1-like 1	Rattus norvegicus	59-64
18976114-0	2009	Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	138-147
18976114-0	2009	Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats.	Curcumin	0-8	interleukin 6	Rattus norvegicus	149-153
18976114-0	2009	Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats.	Curcumin	0-8	mast cell protease 1-like 1	Rattus norvegicus	155-160
18976114-1	2009	This study examined the hypothesis that curcumin supplementation decreases blood levels of IL-6, MCP-1, TNF-alpha, hyperglycemia, and oxidative stress by using a cell-culture model and a diabetic rat model.	Curcumin	40-48	interleukin 6	Rattus norvegicus	91-95
18976114-1	2009	This study examined the hypothesis that curcumin supplementation decreases blood levels of IL-6, MCP-1, TNF-alpha, hyperglycemia, and oxidative stress by using a cell-culture model and a diabetic rat model.	Curcumin	40-48	mast cell protease 1-like 1	Rattus norvegicus	97-102
18976114-1	2009	This study examined the hypothesis that curcumin supplementation decreases blood levels of IL-6, MCP-1, TNF-alpha, hyperglycemia, and oxidative stress by using a cell-culture model and a diabetic rat model.	Curcumin	40-48	tumor necrosis factor	Rattus norvegicus	104-113
18976114-5	2009	Results show that the effect of high glucose on lipid peroxidation, IL-6, IL-8, MCP-1, and TNF-alpha secretion was inhibited by curcumin in cultured monocytes.	Curcumin	128-136	interleukin 6	Rattus norvegicus	68-72
18976114-5	2009	Results show that the effect of high glucose on lipid peroxidation, IL-6, IL-8, MCP-1, and TNF-alpha secretion was inhibited by curcumin in cultured monocytes.	Curcumin	128-136	mast cell protease 1-like 1	Rattus norvegicus	80-85
18976114-5	2009	Results show that the effect of high glucose on lipid peroxidation, IL-6, IL-8, MCP-1, and TNF-alpha secretion was inhibited by curcumin in cultured monocytes.	Curcumin	128-136	tumor necrosis factor	Rattus norvegicus	91-100
18976114-6	2009	In the rat model, diabetes caused a significant increase in blood levels of IL-6, MCP-1, TNF-alpha, glucose, HbA(1), and oxidative stress, which was significantly decreased in curcumin-supplemented rats.	Curcumin	176-184	interleukin 6	Rattus norvegicus	76-80
18976114-6	2009	In the rat model, diabetes caused a significant increase in blood levels of IL-6, MCP-1, TNF-alpha, glucose, HbA(1), and oxidative stress, which was significantly decreased in curcumin-supplemented rats.	Curcumin	176-184	mast cell protease 1-like 1	Rattus norvegicus	82-87
19221248-8	2009	RESULTS: Curcumin treatment resulted in dose-dependent inhibition of IL-6 and IL-8 in all cell lines.	Curcumin	9-17	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
19221248-0	2009	Suppression of interleukin 6 and 8 production in head and neck cancer cells with curcumin via inhibition of Ikappa beta kinase.	Curcumin	81-89	interleukin 6	Homo sapiens	15-28
18976114-6	2009	In the rat model, diabetes caused a significant increase in blood levels of IL-6, MCP-1, TNF-alpha, glucose, HbA(1), and oxidative stress, which was significantly decreased in curcumin-supplemented rats.	Curcumin	176-184	tumor necrosis factor	Rattus norvegicus	89-98
19221248-1	2009	OBJECTIVES: To evaluate the effect of curcumin on production of interleukin 6 (IL-6) and 8 (IL-8) in head and neck squamous cell carcinoma (HNSCC) cell lines and to determine the mechanism by which these effects are modulated.	Curcumin	38-46	interleukin 6	Homo sapiens	64-77
19221248-10	2009	Curcumin treatment resulted in inhibition of IKK activity and inhibition of IL-6 and IL-8 expression.	Curcumin	0-8	interleukin 6	Homo sapiens	76-80
19221248-10	2009	Curcumin treatment resulted in inhibition of IKK activity and inhibition of IL-6 and IL-8 expression.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
19221248-1	2009	OBJECTIVES: To evaluate the effect of curcumin on production of interleukin 6 (IL-6) and 8 (IL-8) in head and neck squamous cell carcinoma (HNSCC) cell lines and to determine the mechanism by which these effects are modulated.	Curcumin	38-46	interleukin 6	Homo sapiens	79-83
19176385-6	2009	Further, we found that curcumin inhibited mTORC1 signaling independently of protein phosphatase 2A (PP2A) or AMP-activated protein kinase AMPK-tuberous sclerosis complex (TSC).	Curcumin	23-31	TSC complex subunit 1	Homo sapiens	171-174
19221248-1	2009	OBJECTIVES: To evaluate the effect of curcumin on production of interleukin 6 (IL-6) and 8 (IL-8) in head and neck squamous cell carcinoma (HNSCC) cell lines and to determine the mechanism by which these effects are modulated.	Curcumin	38-46	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
19221248-2	2009	Curcumin suppression of HNSCC is believed to be partly due to inhibition of the transcription factor nuclear factor-kappa beta (NF-kappa beta).	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	128-142
19221248-7	2009	MAIN OUTCOME MEASURES: Reverse transcription-polymerase chain reaction was performed to determine the effect of curcumin on the expression of IL-6 and IL-8.	Curcumin	112-120	interleukin 6	Homo sapiens	142-146
19221248-7	2009	MAIN OUTCOME MEASURES: Reverse transcription-polymerase chain reaction was performed to determine the effect of curcumin on the expression of IL-6 and IL-8.	Curcumin	112-120	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
19221248-8	2009	RESULTS: Curcumin treatment resulted in dose-dependent inhibition of IL-6 and IL-8 in all cell lines.	Curcumin	9-17	interleukin 6	Homo sapiens	69-73
19221248-11	2009	CONCLUSIONS: Curcumin significantly reduces IL-6 and IL-8 levels in HNSCC cell lines.	Curcumin	13-21	interleukin 6	Homo sapiens	44-48
19221248-11	2009	CONCLUSIONS: Curcumin significantly reduces IL-6 and IL-8 levels in HNSCC cell lines.	Curcumin	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
18814316-2	2009	We report the interaction of a potent synthetic derivative of curcumin, isoxazolcurcumin (IOC) with human serum albumin (HSA) using various biophysical methods.	Curcumin	62-70	albumin	Homo sapiens	106-119
19176385-10	2009	Finally, we identified that curcumin was able to dissociate raptor from mTOR, leading to inhibition of mTORC1 activity.	Curcumin	28-36	mechanistic target of rapamycin kinase	Homo sapiens	72-76
19176385-11	2009	Therefore, our data indicate that curcumin may represent a new class of mTOR inhibitor.	Curcumin	34-42	mechanistic target of rapamycin kinase	Homo sapiens	72-76
19374255-9	2009	In addition, the attenuated activity of MMP-9 was associated with decreased expression of tumor necrosis factor-alpha (TNF-alpha) during healing, suggesting the anti-inflammatory property of curcumin.	Curcumin	191-199	tumor necrosis factor	Mus musculus	90-117
19095035-9	2009	Curcumin-induced apoptosis was mediated by caspase-9 in young but not older rats.	Curcumin	0-8	caspase 9	Rattus norvegicus	43-52
19374255-9	2009	In addition, the attenuated activity of MMP-9 was associated with decreased expression of tumor necrosis factor-alpha (TNF-alpha) during healing, suggesting the anti-inflammatory property of curcumin.	Curcumin	191-199	tumor necrosis factor	Mus musculus	119-128
19235267-4	2009	A decrease in expressions of Bcl-2, Bcl-xL and survivin was observed after exposure to 10 approximately 80 micromol/L curcumin, while the levels of Bax and Bad increased in the curcumin-treated cells.	Curcumin	118-126	BCL2 like 1	Homo sapiens	36-42
19224157-3	2009	The expression of acetylated histone-3 (H(3)) in Raji, HL60 and K562 cells, and peripheral blood mononuclear cells (PBMCs) treated with curcumin or TSA was detected by immunohistochemistry and FACS.	Curcumin	136-144	H3 clustered histone 14	Homo sapiens	29-44
19224157-5	2009	Curcumin induced up-regulation of the expression of acetylated H(3) dose-dependently in all malignant cell lines tested.	Curcumin	0-8	H3 clustered histone 14	Homo sapiens	63-67
19224157-6	2009	In conclusion, curcumin inhibited proliferation of Raji cells selectively, enhanced the level of acetylated (H(3)) in Raji, HL60, and K562 cells, which acted as a histone deacetylase inhibitor like TSA.	Curcumin	15-23	H3 clustered histone 14	Homo sapiens	109-113
19235267-1	2009	OBJECTIVE: To investigate the effects of curcumin on release of cytochrome c and expressions of Bcl-2, Bax, Bad, Bcl-xL, caspase-3, poly ADP-ribose polymerase (PARP), and survivin of HT-29 cells.	Curcumin	41-49	cytochrome c, somatic	Homo sapiens	64-76
19235267-2	2009	METHODS: HT-29 cells were treated with curcumin (0 approximately 80 micromol/L) for 24 h. The release of cytochrome c from the mitochondria and the apoptosis-related proteins Bax, Bcl-2, Bcl-xL, Bad, caspase-3, PARP, and survivin were determined by Western blot analysis and their mRNA expressions by reverse transcriptase-polymerase chain reaction (RT-PCR).	Curcumin	39-47	cytochrome c, somatic	Homo sapiens	105-117
19235267-2	2009	METHODS: HT-29 cells were treated with curcumin (0 approximately 80 micromol/L) for 24 h. The release of cytochrome c from the mitochondria and the apoptosis-related proteins Bax, Bcl-2, Bcl-xL, Bad, caspase-3, PARP, and survivin were determined by Western blot analysis and their mRNA expressions by reverse transcriptase-polymerase chain reaction (RT-PCR).	Curcumin	39-47	BCL2 associated X, apoptosis regulator	Homo sapiens	175-178
19235267-4	2009	A decrease in expressions of Bcl-2, Bcl-xL and survivin was observed after exposure to 10 approximately 80 micromol/L curcumin, while the levels of Bax and Bad increased in the curcumin-treated cells.	Curcumin	118-126	BCL2 apoptosis regulator	Homo sapiens	29-34
19171646-11	2009	The NF-kappaB inhibitor curcumin blocked the effects of IL-1beta on both TER and the subcellular localization of ZO-1 and occludin.	Curcumin	24-32	interleukin 1 beta	Homo sapiens	56-64
19171646-11	2009	The NF-kappaB inhibitor curcumin blocked the effects of IL-1beta on both TER and the subcellular localization of ZO-1 and occludin.	Curcumin	24-32	tight junction protein 1	Homo sapiens	113-130
19235267-4	2009	A decrease in expressions of Bcl-2, Bcl-xL and survivin was observed after exposure to 10 approximately 80 micromol/L curcumin, while the levels of Bax and Bad increased in the curcumin-treated cells.	Curcumin	177-185	BCL2 apoptosis regulator	Homo sapiens	29-34
19235267-4	2009	A decrease in expressions of Bcl-2, Bcl-xL and survivin was observed after exposure to 10 approximately 80 micromol/L curcumin, while the levels of Bax and Bad increased in the curcumin-treated cells.	Curcumin	177-185	BCL2 like 1	Homo sapiens	36-42
19235267-4	2009	A decrease in expressions of Bcl-2, Bcl-xL and survivin was observed after exposure to 10 approximately 80 micromol/L curcumin, while the levels of Bax and Bad increased in the curcumin-treated cells.	Curcumin	177-185	BCL2 associated X, apoptosis regulator	Homo sapiens	148-151
19235267-5	2009	Curcumin also induced the release of cytochrome c, the activation of caspase-3, and the cleavage of PARP in a dose-dependent manner.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	37-49
19235267-5	2009	Curcumin also induced the release of cytochrome c, the activation of caspase-3, and the cleavage of PARP in a dose-dependent manner.	Curcumin	0-8	caspase 3	Homo sapiens	69-78
19235267-5	2009	Curcumin also induced the release of cytochrome c, the activation of caspase-3, and the cleavage of PARP in a dose-dependent manner.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	100-104
19093868-0	2009	Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
18495463-0	2009	Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA.	Curcumin	0-8	plasminogen activator, urokinase	Homo sapiens	137-140
18495463-6	2009	Zymography analysis exhibited that curcumin, DMC and BDMC significantly decreased uPA, active-MMP-2 and MMP-9 but not pro-MMP-2 secretion from the cells in a dose-dependent manner, in which BDMC and DMC show higher potency than curcumin.	Curcumin	35-43	plasminogen activator, urokinase	Homo sapiens	82-85
19002562-0	2009	Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	55-60
19002562-3	2009	In this study, we investigated the effects of curcumin on the expression of TLR-4 and MyD88, the upstream signaling pathway in experimental colitis induced in the Sprague-Dawley male rats by intra-rectal administration of trinitrobenzenesulfonic acid (TNBS).	Curcumin	46-54	toll-like receptor 4	Rattus norvegicus	76-81
19002562-10	2009	Increases in the levels of TLR-4, MyD88, and NFkB proteins in inflamed tissue were also suppressed significantly by curcumin treatment.	Curcumin	116-124	toll-like receptor 4	Rattus norvegicus	27-32
19002562-12	2009	These findings demonstrate that signaling pathway of curcumin-induced inhibition of inflammation involves TLR-4 and MyD88, and therefore may serve as an important therapeutic target in IBD.	Curcumin	53-61	toll-like receptor 4	Rattus norvegicus	106-111
19028451-5	2009	IL-8 up-regulation in response to HSP90 was also attenuated by IkappaB, rasveratrol, curcumin, diphenyleneiodium, N-acetylcystein, U0126, and SB202190.	Curcumin	85-93	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19093868-4	2009	Stimulation of AMPK by curcumin resulted in the down-regulation of PPAR (peroxisome proliferator-activated receptor)-gamma in 3T3-L1 adipocytes and the decrease in COX-2 in MCF-7 cells.	Curcumin	23-31	peroxisome proliferator activated receptor gamma	Homo sapiens	73-122
19093868-4	2009	Stimulation of AMPK by curcumin resulted in the down-regulation of PPAR (peroxisome proliferator-activated receptor)-gamma in 3T3-L1 adipocytes and the decrease in COX-2 in MCF-7 cells.	Curcumin	23-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-169
19093868-7	2009	Regulation of AMPK and its downstream targets such as PPAR-gamma, Mapkinases, and COX-2 by curcumin appears to be important in controlling adipocytes and cancerous cells.	Curcumin	91-99	peroxisome proliferator activated receptor gamma	Homo sapiens	54-64
19093868-7	2009	Regulation of AMPK and its downstream targets such as PPAR-gamma, Mapkinases, and COX-2 by curcumin appears to be important in controlling adipocytes and cancerous cells.	Curcumin	91-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
19033880-4	2009	Daily administration of the CREB-binding protein inhibitor curcumin abolished the upregulation of BDNF transcription and morphine analgesic tolerance.	Curcumin	59-67	CREB binding protein	Homo sapiens	28-48
19889203-8	2009	RESULTS: Treatment with curcumin and resveratrol suppressed NF-kappaB-regulated gene products involved in inflammation (cyclooxygenase-2, matrix metalloproteinase (MMP)-3, MMP-9, vascular endothelial growth factor), inhibited apoptosis (Bcl-2, Bcl-xL, and TNF-alpha receptor-associated factor 1) and prevented activation of caspase-3.	Curcumin	24-32	caspase 3	Homo sapiens	324-333
18815282-5	2009	Against this backdrop of subclinical iron deficiency, curcumin exerted profound 2 effects on systemic iron, inducing a dose-dependent decline in hematocrit, hemoglobin, serum iron, and transferrin saturation, the appearance of microcytic anisocytotic red blood cells, and decreases in spleen and liver iron content.	Curcumin	54-62	transferrin	Homo sapiens	185-196
19331178-6	2009	RESULTS: Curcumin together with BM-ANF1 produced a greater inhibition of HCT-116 cells growth than either agent alone, attributable to the inhibition of proliferation and stimulation of apoptosis, as evidenced by suppression of proliferating cell nuclear antigen (PCNA) expression, cell cycle arrest at the G2/M-phase and caspase-3 activation.	Curcumin	9-17	caspase 3	Homo sapiens	322-331
19889203-0	2009	Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis.	Curcumin	41-49	interleukin 1 beta	Homo sapiens	113-121
19889203-9	2009	IL-1beta-induced NF-kappaB activation was suppressed directly by cocktails of curcumin and resveratrol through inhibition of Ikappakappa and proteasome activation, inhibition of IkappaBalpha phosphorylation and degradation, and inhibition of nuclear translocation of NF-kappaB.	Curcumin	78-86	interleukin 1 beta	Homo sapiens	0-8
19889203-7	2009	The aim of this study was to investigate the potential synergistic effects of curcumin and resveratrol on IL-1beta-stimulated human chondrocytes in vitro using immunoblotting and electron microscopy.	Curcumin	78-86	interleukin 1 beta	Homo sapiens	106-114
19889203-8	2009	RESULTS: Treatment with curcumin and resveratrol suppressed NF-kappaB-regulated gene products involved in inflammation (cyclooxygenase-2, matrix metalloproteinase (MMP)-3, MMP-9, vascular endothelial growth factor), inhibited apoptosis (Bcl-2, Bcl-xL, and TNF-alpha receptor-associated factor 1) and prevented activation of caspase-3.	Curcumin	24-32	prostaglandin-endoperoxide synthase 2	Homo sapiens	120-136
19889203-10	2009	The modulatory effects of curcumin and resveratrol on IL-1beta-induced expression of cartilage specific matrix and proinflammatory enzymes were mediated in part by the cartilage-specific transcription factor Sox-9.	Curcumin	26-34	interleukin 1 beta	Homo sapiens	54-62
19889203-8	2009	RESULTS: Treatment with curcumin and resveratrol suppressed NF-kappaB-regulated gene products involved in inflammation (cyclooxygenase-2, matrix metalloproteinase (MMP)-3, MMP-9, vascular endothelial growth factor), inhibited apoptosis (Bcl-2, Bcl-xL, and TNF-alpha receptor-associated factor 1) and prevented activation of caspase-3.	Curcumin	24-32	matrix metallopeptidase 3	Homo sapiens	138-170
19889203-8	2009	RESULTS: Treatment with curcumin and resveratrol suppressed NF-kappaB-regulated gene products involved in inflammation (cyclooxygenase-2, matrix metalloproteinase (MMP)-3, MMP-9, vascular endothelial growth factor), inhibited apoptosis (Bcl-2, Bcl-xL, and TNF-alpha receptor-associated factor 1) and prevented activation of caspase-3.	Curcumin	24-32	vascular endothelial growth factor A	Homo sapiens	179-213
19319191-10	2009	The activities of thioredoxin (Trx1) and thioredoxin reductase (TrxR1) were significantly elevated, whereas treatment with either curcumin, an irreversible inhibitor of TrxR1, or adiponectin largely attenuated their activities and resulted in the re-activation of PTEN in these tumor cells.	Curcumin	130-138	phosphatase and tensin homolog	Mus musculus	264-268
19889203-8	2009	RESULTS: Treatment with curcumin and resveratrol suppressed NF-kappaB-regulated gene products involved in inflammation (cyclooxygenase-2, matrix metalloproteinase (MMP)-3, MMP-9, vascular endothelial growth factor), inhibited apoptosis (Bcl-2, Bcl-xL, and TNF-alpha receptor-associated factor 1) and prevented activation of caspase-3.	Curcumin	24-32	BCL2 apoptosis regulator	Homo sapiens	237-242
19889203-8	2009	RESULTS: Treatment with curcumin and resveratrol suppressed NF-kappaB-regulated gene products involved in inflammation (cyclooxygenase-2, matrix metalloproteinase (MMP)-3, MMP-9, vascular endothelial growth factor), inhibited apoptosis (Bcl-2, Bcl-xL, and TNF-alpha receptor-associated factor 1) and prevented activation of caspase-3.	Curcumin	24-32	BCL2 like 1	Homo sapiens	244-250
19516890-6	2009	The uptake and efficacy of SF-coated curcumin was significantly higher (p &lt; 0.001) than SFCS-coated curcumin in both low and high Her2/neu expressing breast cancer cells.	Curcumin	37-45	erb-b2 receptor tyrosine kinase 2	Homo sapiens	133-141
19516890-7	2009	Interestingly, the uptake of curcumin was highest for the high Her2/neu expressing breast cancer cells when delivered with a 10% w/v SF coating as compared to other formulations.	Curcumin	29-37	erb-b2 receptor tyrosine kinase 2	Homo sapiens	63-71
19838927-4	2009	Indeed, the combination of curcumin and resveratrol was found to be more effective in inhibiting growth of p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells than either agent alone.	Curcumin	27-35	tumor protein p53	Homo sapiens	107-110
19838927-4	2009	Indeed, the combination of curcumin and resveratrol was found to be more effective in inhibiting growth of p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells than either agent alone.	Curcumin	27-35	tumor protein p53	Homo sapiens	129-132
19002695-12	2009	Furthermore, our data suggest that there is a significant reduction in the activity of iNOS and a rise in the expression of SP-D in lung tissue of different pulmonary aspiration models with curcumin therapy.	Curcumin	190-198	nitric oxide synthase 2	Rattus norvegicus	87-91
18761777-8	2009	Microarray and pathway analyses suggested that the effect of dietary curcumin on colon inflammation could be via an up-regulation of xenobiotic metabolism and a down-regulation of pro-inflammatory pathways, probably mediated by pregnane X receptor (Pxr) and peroxisome proliferator-activated receptor alpha (Ppara) activation of retinoid X receptor (Rxr).	Curcumin	69-77	peroxisome proliferator activated receptor alpha	Mus musculus	258-306
18761777-8	2009	Microarray and pathway analyses suggested that the effect of dietary curcumin on colon inflammation could be via an up-regulation of xenobiotic metabolism and a down-regulation of pro-inflammatory pathways, probably mediated by pregnane X receptor (Pxr) and peroxisome proliferator-activated receptor alpha (Ppara) activation of retinoid X receptor (Rxr).	Curcumin	69-77	peroxisome proliferator activated receptor alpha	Mus musculus	308-313
19519446-7	2009	NF-kappaB is a key factor in the upregulation of inflammatory cytokines that have a high profile in inflammatory diseases, suggesting that curcumin could be a novel therapeutic agent for patients with IBD.	Curcumin	139-147	nuclear factor kappa B subunit 1	Homo sapiens	0-9
19519446-13	2009	The inhibitory effects of curcumin on major inflammatory mechanisms like COX-2, LOX, TNF-alpha, IFN-gamma, NF-kappaB and its unrivalled safety profile suggest that it has bright prospects in the treatment of IBD.	Curcumin	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78
19519446-13	2009	The inhibitory effects of curcumin on major inflammatory mechanisms like COX-2, LOX, TNF-alpha, IFN-gamma, NF-kappaB and its unrivalled safety profile suggest that it has bright prospects in the treatment of IBD.	Curcumin	26-34	tumor necrosis factor	Homo sapiens	85-94
19519446-13	2009	The inhibitory effects of curcumin on major inflammatory mechanisms like COX-2, LOX, TNF-alpha, IFN-gamma, NF-kappaB and its unrivalled safety profile suggest that it has bright prospects in the treatment of IBD.	Curcumin	26-34	interferon gamma	Homo sapiens	96-105
19519446-13	2009	The inhibitory effects of curcumin on major inflammatory mechanisms like COX-2, LOX, TNF-alpha, IFN-gamma, NF-kappaB and its unrivalled safety profile suggest that it has bright prospects in the treatment of IBD.	Curcumin	26-34	nuclear factor kappa B subunit 1	Homo sapiens	107-116
19249123-9	2009	Infected mice treated with curcumin showed low serum level of both interleukin (IL)-12 and tumor necrosis factor alpha (TNF-alpha), but IL-10 level was not significantly altered.	Curcumin	27-35	tumor necrosis factor	Mus musculus	91-118
19249123-9	2009	Infected mice treated with curcumin showed low serum level of both interleukin (IL)-12 and tumor necrosis factor alpha (TNF-alpha), but IL-10 level was not significantly altered.	Curcumin	27-35	tumor necrosis factor	Mus musculus	120-129
19177192-3	2009	Dimethoxycurcumin and curcumin, but not tetrahydrocurcumin, induced HO-1 expression and Nrf2 nuclear translocation, suggesting that the unsaturated nature of the diarylheptanoid chain of the compounds are crucial for HO-1 expression and Nrf2 activation.	Curcumin	9-17	NFE2 like bZIP transcription factor 2	Homo sapiens	88-92
19177192-3	2009	Dimethoxycurcumin and curcumin, but not tetrahydrocurcumin, induced HO-1 expression and Nrf2 nuclear translocation, suggesting that the unsaturated nature of the diarylheptanoid chain of the compounds are crucial for HO-1 expression and Nrf2 activation.	Curcumin	9-17	NFE2 like bZIP transcription factor 2	Homo sapiens	237-241
19194552-7	2009	Pre-treatment of cells with AP-1 inhibitor, curcumin, blocked aldosterone-induced AP-1 DNA binding activity as well as aldosterone-induced TGF-beta(1) production.	Curcumin	44-52	transforming growth factor, beta 1	Rattus norvegicus	139-150
18824136-7	2009	Moreover, both promoter activity and release of IL-8 were inhibited by U0126 and curcumin, but not by SB202190, epigallocatechin 3-gallate and resveratrol.	Curcumin	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
19058955-3	2009	Curcumin is an anti-inflammatory agent that is known to have anti-cox-2 activity.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	66-71
19116450-6	2008	We report that curcumin acts on STAT-3 signal pathway to reduce cell viability and increase apoptosis evaluated by the the amount of activated caspase 3.	Curcumin	15-23	signal transducer and activator of transcription 3	Homo sapiens	32-38
19116450-6	2008	We report that curcumin acts on STAT-3 signal pathway to reduce cell viability and increase apoptosis evaluated by the the amount of activated caspase 3.	Curcumin	15-23	caspase 3	Homo sapiens	143-152
19116450-8	2008	JSI-124, a STAT-3 inhibitor (100 nM) was able to block the negative effect of curcumin on cell viability and caspase 3 activation.	Curcumin	78-86	signal transducer and activator of transcription 3	Homo sapiens	11-17
19116450-8	2008	JSI-124, a STAT-3 inhibitor (100 nM) was able to block the negative effect of curcumin on cell viability and caspase 3 activation.	Curcumin	78-86	caspase 3	Homo sapiens	109-118
18629638-11	2008	Recent findings suggest that several phytochemicals exhibit biphasic dose responses on cells with low doses activating signaling pathways that result in increased expression of vitagenes encoding survival proteins, as in the case of the Keap1/Nrf2/ARE pathway activated by curcumin and NAD/NADH-sirtuin-1 activated by resveratrol.	Curcumin	273-281	kelch like ECH associated protein 1	Homo sapiens	237-242
18701210-2	2008	In this study, we showed that curcumin, a plant product containing the phenolic phytochemical, caused DNA damage and endoplasmic reticulum (ER) stress and mitochondrial-dependent-induced apoptosis through the activation of caspase-3 at a treatment concentration of 30 microM in human lung cancer A-549 cells.	Curcumin	30-38	caspase 3	Homo sapiens	223-232
18701210-5	2008	GADD153 and GRP78 were increased by curcumin which was indicative of ER stress.	Curcumin	36-44	DNA damage inducible transcript 3	Homo sapiens	0-7
18701210-5	2008	GADD153 and GRP78 were increased by curcumin which was indicative of ER stress.	Curcumin	36-44	heat shock protein family A (Hsp70) member 5	Homo sapiens	12-17
19090986-8	2008	Bisdemethoxycurcumin, a natural curcumin, is a minor constituent of turmeric (curry), and it enhances phagocytosis and clearance of Abeta in cells from most AD patients.	Curcumin	12-20	amyloid beta precursor protein	Homo sapiens	132-137
18637147-6	2008	MTT assay revealed that the growth inhibition in response to curcumin was significantly low in cells maintained on collagen I. Apoptotic marker activities such as DNA fragmentation, 4",6"-diamidino-2-phenylindole dihydrochloride (DAPI) staining, annexin staining and caspase-3 activities showed that cells maintained on collagen I showed minimal apoptosis than those maintained on collagen IV, laminin and polylysine, showing the influence of ECM on HSC apoptosis.	Curcumin	61-69	caspase 3	Homo sapiens	267-276
19484960-16	2009	CONCLUSIONS: Curcumin can induce apoptosis of pulmonary fibroblasts in rats with bleomycin-induced pulmonary fibrosis and the mechanism may be related to the activation of Caspase-3, Caspase-8, and Caspase-9.	Curcumin	13-21	caspase 9	Rattus norvegicus	198-207
19383353-5	2008	Upon treatment with curcumin, IL-6/sIL-6R-induced STAT3 and Erk phosphorylation was dramatically reduced in the co-cultured cells.	Curcumin	20-28	interleukin 6	Homo sapiens	30-34
19383353-5	2008	Upon treatment with curcumin, IL-6/sIL-6R-induced STAT3 and Erk phosphorylation was dramatically reduced in the co-cultured cells.	Curcumin	20-28	signal transducer and activator of transcription 3	Homo sapiens	50-55
19383353-5	2008	Upon treatment with curcumin, IL-6/sIL-6R-induced STAT3 and Erk phosphorylation was dramatically reduced in the co-cultured cells.	Curcumin	20-28	mitogen-activated protein kinase 1	Homo sapiens	60-63
19383353-6	2008	In addition, curcumin inhibited the production of pro-inflammatory cytokines and VEGF, factors that are associated with the progression of multiple myeloma, from both MM cells and BMSCs.	Curcumin	13-21	vascular endothelial growth factor A	Homo sapiens	81-85
19383353-7	2008	In a combination treatment with curcumin and bortezomib, IL-6/sIL-6R-induced STAT3 and Erk phosphorylation was effectively inhibited.	Curcumin	32-40	interleukin 6	Homo sapiens	57-61
19383353-7	2008	In a combination treatment with curcumin and bortezomib, IL-6/sIL-6R-induced STAT3 and Erk phosphorylation was effectively inhibited.	Curcumin	32-40	signal transducer and activator of transcription 3	Homo sapiens	77-82
19383353-7	2008	In a combination treatment with curcumin and bortezomib, IL-6/sIL-6R-induced STAT3 and Erk phosphorylation was effectively inhibited.	Curcumin	32-40	mitogen-activated protein kinase 1	Homo sapiens	87-90
18629638-11	2008	Recent findings suggest that several phytochemicals exhibit biphasic dose responses on cells with low doses activating signaling pathways that result in increased expression of vitagenes encoding survival proteins, as in the case of the Keap1/Nrf2/ARE pathway activated by curcumin and NAD/NADH-sirtuin-1 activated by resveratrol.	Curcumin	273-281	NFE2 like bZIP transcription factor 2	Homo sapiens	243-247
18728006-3	2008	Here, we report that apocyclen attached to selective Abeta recognition motifs (KLVFF or curcumin) can capture copper bound to Abeta and use the Cu(II) in place of Co(III) to become proteolytically active.	Curcumin	88-96	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	163-169
19020741-3	2008	Our study demonstrated that chemopreventive agent curcumin strongly activates AMPK in a p38-dependent manner in CaOV3 ovarian cancer cells.	Curcumin	50-58	mitogen-activated protein kinase 14	Homo sapiens	88-91
19020741-4	2008	Pretreatment of cells with compound C (AMPK inhibitor) and SB203580 (p38 inhibitor) attenuates curcumin-induced cell death.	Curcumin	95-103	mitogen-activated protein kinase 14	Homo sapiens	69-72
19020741-5	2008	We also observed that curcumin induces p53 phosphorylation (Ser 15) and both compound C and SB203580 pretreatment inhibit p53 phosphorylation.	Curcumin	22-30	tumor protein p53	Homo sapiens	39-42
18723006-5	2008	Treatment of curcumin and/or vitamin E to T4-treated rats resulted in elevation of SOD level in postmitochondrial fraction (PMF) and mitochondrial fraction (MF) and CAT in PMF, with decreased GPx activity in MF.	Curcumin	13-21	catalase	Rattus norvegicus	165-168
18611416-7	2008	Curcumin reduced post-ischemic brain neutrophil infiltration, nitrate and nitrite levels and ameliorated the loss of GSH-Px and tends to increase the GSH levels but not significantly in the brain tissue.	Curcumin	0-8	glutathione peroxidase 1	Rattus norvegicus	117-123
18695642-7	2008	KEY RESULTS: Curcumin protected islets from cytokine-induced islet death in vitro by scavenging ROS and normalized cytokine-induced NF-kappaB translocation by inhibiting phosphorylation of inhibitor of kappa B alpha (IkappaBalpha).	Curcumin	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	217-229
18818316-10	2008	In vitro studies suggest that the protective effects of curcumin are IL-10 dependent.	Curcumin	56-64	interleukin 10	Mus musculus	69-74
18325727-0	2008	Involvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophages.	Curcumin	78-86	heme oxygenase 1	Mus musculus	33-49
18325727-1	2008	Curcumin, at high concentrations (&gt;2 microM), inhibits the production of nitric oxide (NO) and the expression of inducible NO synthase (iNOS) through inactivation of nuclear factor (NF)-kappaB and, at low concentrations, induces the expression of heme oxygenase (HO)-1 in macrophages.	Curcumin	0-8	nitric oxide synthase 2, inducible	Mus musculus	116-137
18325727-1	2008	Curcumin, at high concentrations (&gt;2 microM), inhibits the production of nitric oxide (NO) and the expression of inducible NO synthase (iNOS) through inactivation of nuclear factor (NF)-kappaB and, at low concentrations, induces the expression of heme oxygenase (HO)-1 in macrophages.	Curcumin	0-8	nitric oxide synthase 2, inducible	Mus musculus	139-143
18325727-1	2008	Curcumin, at high concentrations (&gt;2 microM), inhibits the production of nitric oxide (NO) and the expression of inducible NO synthase (iNOS) through inactivation of nuclear factor (NF)-kappaB and, at low concentrations, induces the expression of heme oxygenase (HO)-1 in macrophages.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	169-195
18325727-1	2008	Curcumin, at high concentrations (&gt;2 microM), inhibits the production of nitric oxide (NO) and the expression of inducible NO synthase (iNOS) through inactivation of nuclear factor (NF)-kappaB and, at low concentrations, induces the expression of heme oxygenase (HO)-1 in macrophages.	Curcumin	0-8	heme oxygenase 1	Mus musculus	250-271
18325727-2	2008	Here, we demonstrated that curcumin at low concentrations (0.5-2 microM) can also inhibit NO production and iNOS expression in lipopolysaccharide (LPS)-activated RAW264.7 macrophages only when the cells were pretreated for at least 6h with curcumin.	Curcumin	27-35	nitric oxide synthase 2, inducible	Mus musculus	108-112
18325727-3	2008	Curcumin induced dose- and time-dependent HO-1 expression, and this was coincident with the inhibitory effects of low concentrations of curcumin on NO production and iNOS expression.	Curcumin	0-8	heme oxygenase 1	Mus musculus	42-46
18325727-3	2008	Curcumin induced dose- and time-dependent HO-1 expression, and this was coincident with the inhibitory effects of low concentrations of curcumin on NO production and iNOS expression.	Curcumin	0-8	nitric oxide synthase 2, inducible	Mus musculus	166-170
18325727-3	2008	Curcumin induced dose- and time-dependent HO-1 expression, and this was coincident with the inhibitory effects of low concentrations of curcumin on NO production and iNOS expression.	Curcumin	136-144	heme oxygenase 1	Mus musculus	42-46
18325727-3	2008	Curcumin induced dose- and time-dependent HO-1 expression, and this was coincident with the inhibitory effects of low concentrations of curcumin on NO production and iNOS expression.	Curcumin	136-144	nitric oxide synthase 2, inducible	Mus musculus	166-170
18325727-4	2008	Blockage of HO-1 activity or knockdown of HO-1 expression abolished the inhibitory effects of curcumin.	Curcumin	94-102	heme oxygenase 1	Mus musculus	12-16
18325727-4	2008	Blockage of HO-1 activity or knockdown of HO-1 expression abolished the inhibitory effects of curcumin.	Curcumin	94-102	heme oxygenase 1	Mus musculus	42-46
18325727-5	2008	Over-expression of HO-1 or exogenous addition of carbon monoxide, a byproduct derived from heme degradation, mimicked the inhibitory action of low concentrations of curcumin.	Curcumin	165-173	heme oxygenase 1	Mus musculus	19-23
18325727-6	2008	Moreover, LPS-induced NF-kappaB was diminished in macrophages subjected to prolonged treatment with low concentrations of curcumin.	Curcumin	122-130	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	22-31
18325727-7	2008	Treatment with HO inhibitor abolished the inhibitory effect of curcumin on LPS-induced NF-kappaB activation.	Curcumin	63-71	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-96
18325727-8	2008	Collectively, we provide evidence to support the important role of HO-1 in inhibition of NO production and iNOS expression by curcumin even at low concentrations.	Curcumin	126-134	heme oxygenase 1	Mus musculus	67-71
18325727-8	2008	Collectively, we provide evidence to support the important role of HO-1 in inhibition of NO production and iNOS expression by curcumin even at low concentrations.	Curcumin	126-134	nitric oxide synthase 2, inducible	Mus musculus	107-111
18940397-2	2008	Curcumin significantly lowered the levels of free fatty acid, total cholesterol, triglyceride, and leptin and the homeostasis model assessment of insulin resistance index, whereas it elevated the levels of high-density lipoprotein cholesterol and apolipoprotein (apo) A-I and paraoxonase activity in plasma, compared with the control group.	Curcumin	0-8	insulin	Homo sapiens	146-153
18596194-0	2008	Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	18-22
18596194-5	2008	METHODS: The antiangiogenic effect of curcumin on in vitro angiogenesis was examined using primary cultures of human intestinal microvascular endothelial cells (HIMECs), stimulated with vascular endothelial growth factor (VEGF).	Curcumin	38-46	vascular endothelial growth factor A	Homo sapiens	186-220
18596194-6	2008	RESULTS: Curcumin inhibited proliferation, cell migration and tube formation in HIMECs induced by VEGF.	Curcumin	9-17	vascular endothelial growth factor A	Homo sapiens	98-102
18997590-0	2008	Re: Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cell.	Curcumin	4-12	vascular endothelial growth factor A	Homo sapiens	47-51
18953351-7	2008	This unique calcium phenotype represents a new target for therapeutic intervention, as elevation of cytosolic calcium with curcumin normalized NPC1 disease cellular phenotypes and prolonged survival of the NPC1 mouse.	Curcumin	123-131	NPC intracellular cholesterol transporter 1	Mus musculus	143-147
19176142-9	2008	RESULTS: Given 4 weeks the different dose of curcumin on the simplicity obesity rats, the significant diminished weight (435.0 +/- 37.6) g and content of lipocyte (4.78 +/- 1.87) g as compared with the obesity model control (492.3 +/- 14.8) g and (8.94 +/- 1.88) g (t values were 4.484 and 4.961 respectively, P &lt; 0.01), level of blood sugar (4.50 +/- 0.09) mmol/L, insulin (7.43 +/- 0.65) mmol/L, leptin (3.40 +/- 0.39) mmol/L and TNF-alpha (2.42 +/- 0.19) ng/ml were significantly decreased than those of adiposity model rats (4.94 +/- 0.12) mmol/L, (9.30 +/- 0.21) mmol/L, (4.40 +/- 0.23) mmol/L and (2.86 +/- 0.49) ng/ml (t values were 8.297, 7.743, 6.247 and 2.368 respectively, P &lt; 0.05), and there was no significant difference with the control group (4.30 +/- 0.14) mmol/L on the level of blood sugar (t = 0.399, P &gt; 0.05).	Curcumin	45-53	tumor necrosis factor	Rattus norvegicus	435-444
18664365-9	2008	Both the febrile response and overproduction of both glutamate and hydroxyl radicals in the hypothalamus caused by central administration of TNF-alpha, IL-1beta, or IL-6 could be suppressed by Curcumin.	Curcumin	193-201	interleukin-1 beta	Oryctolagus cuniculus	152-160
18706396-0	2008	Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide.	Curcumin	0-8	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	20-29
18706396-3	2008	To address this problem, curcumin was injected into the peritoneum of ovalbumin (OVA)-sensitized mice before the last allergen challenge.	Curcumin	25-33	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	70-79
18706396-5	2008	These effects of ovalbumin challenge were all inhibited by pretreatment of mice with curcumin.	Curcumin	85-93	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	17-26
18706396-6	2008	Furthermore, supplementation with curcumin in the A549 human airway epithelial cells decreased iNOS and NO production induced by IFN-gamma.	Curcumin	34-42	interferon gamma	Homo sapiens	129-138
19138983-6	2008	Consistent with this finding, curcumin also blocked alpha(6)beta(4)-dependent Akt activation and expression of the cell motility-promoting factor ENPP2 in MDA-MB-435/beta4 cell line.	Curcumin	30-38	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	146-151
18639521-6	2008	Curcumin prevents DCs from responding to immunostimulants and inducing CD4(+) T cell proliferation by blocking maturation marker, cytokine and chemokine expression and reducing both migration and endocytosis.	Curcumin	0-8	CD4 molecule	Homo sapiens	71-74
19260281-5	2008	RESULTS: Curcumine had obvious inhibitory effect on the growth of mouse B16 melanoma in time and dose dependent manner and the gene expression of bcl-2 in B16 cells decreased after 24 hours supplied with curcumine, whereas P53 protein expression increased; Curcumine depressed the GSH quantity in melanoma tissues.	Curcumin	204-213	B cell leukemia/lymphoma 2	Mus musculus	146-151
19260281-5	2008	RESULTS: Curcumine had obvious inhibitory effect on the growth of mouse B16 melanoma in time and dose dependent manner and the gene expression of bcl-2 in B16 cells decreased after 24 hours supplied with curcumine, whereas P53 protein expression increased; Curcumine depressed the GSH quantity in melanoma tissues.	Curcumin	257-266	B cell leukemia/lymphoma 2	Mus musculus	146-151
19260281-7	2008	Curcumine can induce some cells to apoptosis which may be relevant to downregulation of bcl-2 expression and upregulation of P53 expression as well as exhaustion of GSH in tumor organization.	Curcumin	0-9	B cell leukemia/lymphoma 2	Mus musculus	88-93
18214481-7	2008	We also find that curcumin, a well known anti-ovarian cancer drug, down-regulates AQP3 expression and reduces cell migration in CaOV3, and the effects of curcumin are mediated, at least in part, by its inhibitory effects on EGFR and downstream AKT/ERK activation.	Curcumin	18-26	epidermal growth factor receptor	Homo sapiens	224-228
18214481-7	2008	We also find that curcumin, a well known anti-ovarian cancer drug, down-regulates AQP3 expression and reduces cell migration in CaOV3, and the effects of curcumin are mediated, at least in part, by its inhibitory effects on EGFR and downstream AKT/ERK activation.	Curcumin	18-26	AKT serine/threonine kinase 1	Homo sapiens	244-247
18214481-7	2008	We also find that curcumin, a well known anti-ovarian cancer drug, down-regulates AQP3 expression and reduces cell migration in CaOV3, and the effects of curcumin are mediated, at least in part, by its inhibitory effects on EGFR and downstream AKT/ERK activation.	Curcumin	18-26	mitogen-activated protein kinase 1	Homo sapiens	248-251
18214481-7	2008	We also find that curcumin, a well known anti-ovarian cancer drug, down-regulates AQP3 expression and reduces cell migration in CaOV3, and the effects of curcumin are mediated, at least in part, by its inhibitory effects on EGFR and downstream AKT/ERK activation.	Curcumin	154-162	epidermal growth factor receptor	Homo sapiens	224-228
18214481-7	2008	We also find that curcumin, a well known anti-ovarian cancer drug, down-regulates AQP3 expression and reduces cell migration in CaOV3, and the effects of curcumin are mediated, at least in part, by its inhibitory effects on EGFR and downstream AKT/ERK activation.	Curcumin	154-162	AKT serine/threonine kinase 1	Homo sapiens	244-247
18214481-7	2008	We also find that curcumin, a well known anti-ovarian cancer drug, down-regulates AQP3 expression and reduces cell migration in CaOV3, and the effects of curcumin are mediated, at least in part, by its inhibitory effects on EGFR and downstream AKT/ERK activation.	Curcumin	154-162	mitogen-activated protein kinase 1	Homo sapiens	248-251
18829502-0	2008	Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway.	Curcumin	22-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-164
18829502-0	2008	Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway.	Curcumin	22-30	thymoma viral proto-oncogene 1	Mus musculus	171-174
18829502-3	2008	A reporter gene assay was done on cell lines to study the effect of liposomal curcumin on nuclear factor kappaB (NFkappaB) activation.	Curcumin	78-86	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-111
18829502-3	2008	A reporter gene assay was done on cell lines to study the effect of liposomal curcumin on nuclear factor kappaB (NFkappaB) activation.	Curcumin	78-86	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-121
18829502-4	2008	Western blot analysis was done to determine the effect of curcumin on the expression of NFkappaB, phospho-IkappaBalpha, phospho-AKT (pAKT), phospho-S6 kinase, cyclin D1, cyclooxygenase-2, matrix metalloproteinase-9, Bcl-2, Bcl-xL, Mcl-1L, and Mcl-1S.	Curcumin	58-66	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-96
18829502-4	2008	Western blot analysis was done to determine the effect of curcumin on the expression of NFkappaB, phospho-IkappaBalpha, phospho-AKT (pAKT), phospho-S6 kinase, cyclin D1, cyclooxygenase-2, matrix metalloproteinase-9, Bcl-2, Bcl-xL, Mcl-1L, and Mcl-1S.	Curcumin	58-66	thymoma viral proto-oncogene 1	Mus musculus	128-131
18829502-7	2008	Immunohistochemistry and Western blot analyses were used to study the effect of liposomal curcumin on the expression of NFkappaB and pAKT.	Curcumin	90-98	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-128
18829502-9	2008	Liposomal curcumin treatment suppressed the activation of NFkappaB without affecting the expression of pAKT or its downstream target phospho-S6 kinase.	Curcumin	10-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	58-66
18829502-15	2008	The results suggest that liposomal curcumin is a viable nontoxic therapeutic agent for HNSCC that may work via an AKT-independent pathway.	Curcumin	35-43	thymoma viral proto-oncogene 1	Mus musculus	114-117
18852135-0	2008	Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt"s lymphoma cell lines.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	94-97
18852135-1	2008	We provide evidence that curcumin, a natural compound isolated from rhizomes of plant Curcuma longa, induces apoptosis in several Burkitt"s lymphoma cell lines expressing Bax protein (AS283A, KK124, and Pa682PB), whereas it has no effects in cell lines with no Bax expression (BML895 and CA46).	Curcumin	25-33	BCL2 associated X, apoptosis regulator	Homo sapiens	171-174
18852135-1	2008	We provide evidence that curcumin, a natural compound isolated from rhizomes of plant Curcuma longa, induces apoptosis in several Burkitt"s lymphoma cell lines expressing Bax protein (AS283A, KK124, and Pa682PB), whereas it has no effects in cell lines with no Bax expression (BML895 and CA46).	Curcumin	25-33	BCL2 associated X, apoptosis regulator	Homo sapiens	261-264
18852135-2	2008	Our data show that curcumin treatment results in down-regulation of constitutive activation of nuclear factor-kappaB (NF-kappaB) via generation of reactive oxygen species where it causes conformational changes in Bax protein leading to loss of mitochondrial membrane potential and release of cytochrome c to the cytosol.	Curcumin	19-27	BCL2 associated X, apoptosis regulator	Homo sapiens	213-216
18852135-2	2008	Our data show that curcumin treatment results in down-regulation of constitutive activation of nuclear factor-kappaB (NF-kappaB) via generation of reactive oxygen species where it causes conformational changes in Bax protein leading to loss of mitochondrial membrane potential and release of cytochrome c to the cytosol.	Curcumin	19-27	cytochrome c, somatic	Homo sapiens	292-304
18852135-5	2008	Importantly, cotreatment with curcumin and TRAIL induces apoptosis in Bax-deficient cell lines.	Curcumin	30-38	BCL2 associated X, apoptosis regulator	Homo sapiens	70-73
18852135-6	2008	Taken together, our findings suggest that curcumin is able to induce apoptosis in Bax-positive cell lines, whereas combinations with TRAIL result in apoptosis in Bax-negative cell lines.	Curcumin	42-50	BCL2 associated X, apoptosis regulator	Homo sapiens	82-85
18664365-9	2008	Both the febrile response and overproduction of both glutamate and hydroxyl radicals in the hypothalamus caused by central administration of TNF-alpha, IL-1beta, or IL-6 could be suppressed by Curcumin.	Curcumin	193-201	interleukin-6	Oryctolagus cuniculus	165-169
18664365-10	2008	These results indicate that systemic injection of Curcumin may exert its antipyresis by inhibiting the glutamate-hydroxyl radicals-PGE(2) pathways in the hypothalamus and circulating TNF-alpha, IL-1beta, and IL-6 accumulation during LPS fever.	Curcumin	50-58	interleukin-1 beta	Oryctolagus cuniculus	194-202
18664365-10	2008	These results indicate that systemic injection of Curcumin may exert its antipyresis by inhibiting the glutamate-hydroxyl radicals-PGE(2) pathways in the hypothalamus and circulating TNF-alpha, IL-1beta, and IL-6 accumulation during LPS fever.	Curcumin	50-58	interleukin-6	Oryctolagus cuniculus	208-212
18811964-7	2008	Inhibition of NF-kappaB by the pharmacologic inhibitor curcumin (20 microM) or suppression of p65 by siRNA resulted in a significant increase in cell death in response to cigarette smoke exposure.	Curcumin	55-63	nuclear factor kappa B subunit 1	Homo sapiens	14-23
18638545-0	2008	Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-kappaB, and JNK pathways.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	98-107
18794131-8	2008	Curcumin was able to induce c-Jun NH(2)-kinase (JNK) phosphorylation, whereas the JNK inhibitor (SP-600125) could attenuate curcumin-induced JunD and HLJ1 expression.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	28-46
18794131-8	2008	Curcumin was able to induce c-Jun NH(2)-kinase (JNK) phosphorylation, whereas the JNK inhibitor (SP-600125) could attenuate curcumin-induced JunD and HLJ1 expression.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	48-51
18794131-8	2008	Curcumin was able to induce c-Jun NH(2)-kinase (JNK) phosphorylation, whereas the JNK inhibitor (SP-600125) could attenuate curcumin-induced JunD and HLJ1 expression.	Curcumin	124-132	mitogen-activated protein kinase 8	Homo sapiens	82-85
18794131-9	2008	Activation of HLJ1 by curcumin further leads to up-regulation of E-cadherin and a suppression of cancer cell invasion.	Curcumin	22-30	cadherin 1	Homo sapiens	65-75
18794131-10	2008	Our results show that curcumin induces HLJ1, through activation of the JNK/JunD pathway, and inhibits lung cancer cell invasion and metastasis by modulating E-cadherin expression.	Curcumin	22-30	mitogen-activated protein kinase 8	Homo sapiens	71-74
18794131-10	2008	Our results show that curcumin induces HLJ1, through activation of the JNK/JunD pathway, and inhibits lung cancer cell invasion and metastasis by modulating E-cadherin expression.	Curcumin	22-30	cadherin 1	Homo sapiens	157-167
18638545-0	2008	Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-kappaB, and JNK pathways.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	113-116
18638545-5	2008	This confirms that the protective effect of curcumin is not related simply to its antioxidant properties but involves other mechanisms, notably interactions in the NF-kappaB and JNK pathways.	Curcumin	44-52	nuclear factor kappa B subunit 1	Homo sapiens	164-173
18638545-5	2008	This confirms that the protective effect of curcumin is not related simply to its antioxidant properties but involves other mechanisms, notably interactions in the NF-kappaB and JNK pathways.	Curcumin	44-52	mitogen-activated protein kinase 8	Homo sapiens	178-181
18719366-6	2008	Of note, curcumin downregulated transcript encoded by the potentially causal TMPRSS2-ERG gene fusion, a common oncogenic alteration noted in 50-70% of prostate cancer patients.	Curcumin	9-17	transmembrane serine protease 2	Homo sapiens	77-84
18421014-0	2008	Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2.	Curcumin	0-8	histone deacetylase 2	Homo sapiens	90-95
18421014-3	2008	We demonstrate here that curcumin (diferuloylmethane), a dietary polyphenol, at nanomolar concentrations specifically restores cigarette smoke extract (CSE)- or oxidative stress-impaired HDAC2 activity and corticosteroid efficacy in vitro with an EC(50) of approximately 30 nM and 200 nM, respectively.	Curcumin	25-33	histone deacetylase 2	Homo sapiens	187-192
18421014-3	2008	We demonstrate here that curcumin (diferuloylmethane), a dietary polyphenol, at nanomolar concentrations specifically restores cigarette smoke extract (CSE)- or oxidative stress-impaired HDAC2 activity and corticosteroid efficacy in vitro with an EC(50) of approximately 30 nM and 200 nM, respectively.	Curcumin	35-52	histone deacetylase 2	Homo sapiens	187-192
18421014-4	2008	CSE caused a reduction in HDAC2 protein expression that was restored by curcumin.	Curcumin	72-80	histone deacetylase 2	Homo sapiens	26-31
18421014-5	2008	This decrease in HDAC2 protein expression was reversed by curcumin even in the presence of cycloheximide, a protein synthesis inhibitor.	Curcumin	58-66	histone deacetylase 2	Homo sapiens	17-22
18421014-7	2008	Biochemical and gene chip analysis indicated that curcumin at concentrations up to 1 muM propagates its effect via antioxidant-independent mechanisms associated with the phosphorylation-ubiquitin-proteasome pathway.	Curcumin	50-58	latexin	Homo sapiens	85-88
18421014-8	2008	Thus curcumin acts at a post-translational level by maintaining both HDAC2 activity and expression, thereby reversing steroid insensitivity induced by either CSE or oxidative stress in monocytes.	Curcumin	5-13	histone deacetylase 2	Homo sapiens	69-74
18034345-10	2008	The treatment of leukemic cell lines with non-cytotoxic doses (5, 10, and 15 microM) of pure curcumin for 2 days reduced the level of WT1 mRNA expression and WT1 protein in a dose-dependent manner.	Curcumin	93-101	WT1 transcription factor	Homo sapiens	134-137
18034345-10	2008	The treatment of leukemic cell lines with non-cytotoxic doses (5, 10, and 15 microM) of pure curcumin for 2 days reduced the level of WT1 mRNA expression and WT1 protein in a dose-dependent manner.	Curcumin	93-101	WT1 transcription factor	Homo sapiens	158-161
18034345-11	2008	In addition, pure curcumin at 10 microM significantly decreased the level of WT1 mRNA and protein in a time-dependent manner.	Curcumin	18-26	WT1 transcription factor	Homo sapiens	77-80
18034345-12	2008	CONCLUSION: Pure curcumin, an excellent curcuminoid derivative, decreased WT1 gene expression in both transcriptional and translational levels.	Curcumin	17-25	WT1 transcription factor	Homo sapiens	74-77
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Curcumin	405-413	mitogen-activated protein kinase 1	Homo sapiens	106-143
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Curcumin	405-413	mitogen-activated protein kinase 1	Homo sapiens	145-148
18034345-9	2008	Pure curcumin exhibited a strong inhibitory effect on WT1 mRNA and WT1 protein expression.	Curcumin	5-13	WT1 transcription factor	Homo sapiens	54-57
18034345-9	2008	Pure curcumin exhibited a strong inhibitory effect on WT1 mRNA and WT1 protein expression.	Curcumin	5-13	WT1 transcription factor	Homo sapiens	67-70
18719366-6	2008	Of note, curcumin downregulated transcript encoded by the potentially causal TMPRSS2-ERG gene fusion, a common oncogenic alteration noted in 50-70% of prostate cancer patients.	Curcumin	9-17	ETS transcription factor ERG	Homo sapiens	85-88
18719366-7	2008	Further more, expression of EGFR and ERBB2 receptor were found to be downregulated in curcumin treated LNCaP and C4-2B cells.	Curcumin	86-94	epidermal growth factor receptor	Homo sapiens	28-32
18719366-7	2008	Further more, expression of EGFR and ERBB2 receptor were found to be downregulated in curcumin treated LNCaP and C4-2B cells.	Curcumin	86-94	erb-b2 receptor tyrosine kinase 2	Homo sapiens	37-42
18577686-0	2008	Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin.	Curcumin	152-160	nuclear factor kappa B subunit 1	Homo sapiens	29-50
18463970-0	2008	15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte.	Curcumin	45-53	toll-like receptor 4	Mus musculus	81-108
18463970-6	2008	It is interesting to note that in vivo treatment with 15d-PGJ2 or curcumin results in a significant decrease in TLR4 and TLR9 expression in CD4(+) and CD8(+) T cells in association with the amelioration of EAE.	Curcumin	66-74	toll-like receptor 4	Mus musculus	112-116
18327875-6	2008	Curcumin is a polyphenol present in the spice turmeric, which can directly scavenge free radicals such as superoxide anion and nitric oxide and modulate important signaling pathways mediated via NF-kappaB and mitogen-activated protein kinase pathways.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	195-204
18384098-4	2008	Curcumin can also activate apoptosis, down-regulate cell survival gene products, and up-regulate p53, p21, and p27.	Curcumin	0-8	tumor protein p53	Homo sapiens	97-100
18398869-6	2008	In db/db mice, curcumin significantly lowered the hepatic activities of fatty acid synthase, beta-oxidation, 3-hydroxy-3-methylglutaryl coenzyme reductase, and acyl-CoA: cholesterol acyltransferase.	Curcumin	15-23	fatty acid synthase	Mus musculus	72-91
18398869-8	2008	Curcumin normalized erythrocyte and hepatic antioxidant enzyme activities (superoxide dismutase, catalase, gluthathione peroxidase) in db/db mice that resulted in a significant reduction in lipid peroxidation.	Curcumin	0-8	catalase	Mus musculus	97-105
18577686-2	2008	Many naturally occurring substances, including curcumin, have been investigated for their actions on the NF-kappaB pathway because of their significant therapeutic potential and safety profile.	Curcumin	47-55	nuclear factor kappa B subunit 1	Homo sapiens	105-114
21479462-0	2008	Curcumin suppresses breast tumor angiogenesis by abrogating osteopontin-induced VEGF expression.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	80-84
18481332-0	2008	Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS.	Curcumin	9-17	nitric oxide synthase 2	Homo sapiens	106-127
18481332-0	2008	Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-kappaB activation in RAW264.7 macrophages activated with LPS.	Curcumin	9-17	nuclear factor kappa B subunit 1	Homo sapiens	143-152
18481332-3	2008	We investigated whether dimethoxycurcumin (DiMC), a synthetic curcumin analogue with higher metabolic stability over curcumin, could inhibit NO production and iNOS expression in activated macrophages.	Curcumin	33-41	nitric oxide synthase 2	Homo sapiens	159-163
18481332-6	2008	DiMC, curcumin and BDMC inhibited NO production, iNOS expression and NF-kappaB activation, with DiMC being the most effective, followed by curcumin and BDMC.	Curcumin	6-14	nitric oxide synthase 2	Homo sapiens	49-53
18481332-6	2008	DiMC, curcumin and BDMC inhibited NO production, iNOS expression and NF-kappaB activation, with DiMC being the most effective, followed by curcumin and BDMC.	Curcumin	6-14	nuclear factor kappa B subunit 1	Homo sapiens	69-78
21479462-6	2008	In this study, we demonstrate that curcumin (diferuloylmethane) abrogates OPN-induced VEGF expression and curbs OPN-induced VEGF-dependent breast tumor angiogenesis in vivo.	Curcumin	35-43	vascular endothelial growth factor A	Homo sapiens	86-90
21479462-6	2008	In this study, we demonstrate that curcumin (diferuloylmethane) abrogates OPN-induced VEGF expression and curbs OPN-induced VEGF-dependent breast tumor angiogenesis in vivo.	Curcumin	35-43	vascular endothelial growth factor A	Homo sapiens	124-128
18790744-0	2008	Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	18-21
18790744-0	2008	Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	22-51
18790744-2	2008	Curcumin has been shown to effectively prevent or inhibit prostate cancer in vivo and inhibit Akt/mTOR signaling in vitro, but the mechanism(s) remains unclear.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	94-97
18790744-2	2008	Curcumin has been shown to effectively prevent or inhibit prostate cancer in vivo and inhibit Akt/mTOR signaling in vitro, but the mechanism(s) remains unclear.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	98-102
18790744-3	2008	Here, we show that curcumin concentration- and time-dependently inhibited the phosphorylation of Akt, mTOR, and their downstream substrates in human prostate cancer PC-3 cells, and this inhibitory effect acts downstream of phosphatidylinositol 3-kinase and phosphatidylinositol-dependent kinase 1.	Curcumin	19-27	AKT serine/threonine kinase 1	Homo sapiens	97-100
18790744-3	2008	Here, we show that curcumin concentration- and time-dependently inhibited the phosphorylation of Akt, mTOR, and their downstream substrates in human prostate cancer PC-3 cells, and this inhibitory effect acts downstream of phosphatidylinositol 3-kinase and phosphatidylinositol-dependent kinase 1.	Curcumin	19-27	mechanistic target of rapamycin kinase	Homo sapiens	102-106
18790744-4	2008	Overexpression of constitutively activated Akt or disruption of TSC1-TSC2 complex by small interfering RNA or gene knockout only partially restored curcumin-mediated inhibition of mTOR and downstream signaling, indicating that they are not the primary effectors of curcumin-mediated inhibition of Akt/mTOR signaling.	Curcumin	148-156	mechanistic target of rapamycin kinase	Homo sapiens	180-184
18790744-6	2008	Finally, it was shown that the inhibition of Akt/mTOR signaling by curcumin is resulted from calyculin A-sensitive protein phosphatase-dependent dephosphorylation.	Curcumin	67-75	AKT serine/threonine kinase 1	Homo sapiens	45-48
18790744-6	2008	Finally, it was shown that the inhibition of Akt/mTOR signaling by curcumin is resulted from calyculin A-sensitive protein phosphatase-dependent dephosphorylation.	Curcumin	67-75	mechanistic target of rapamycin kinase	Homo sapiens	49-53
18790744-7	2008	Our study reveals the profound effects of curcumin on the Akt/mTOR signaling network in PC-3 cells and provides new mechanisms for the anticancer effects of curcumin.	Curcumin	42-50	AKT serine/threonine kinase 1	Homo sapiens	58-61
18790744-7	2008	Our study reveals the profound effects of curcumin on the Akt/mTOR signaling network in PC-3 cells and provides new mechanisms for the anticancer effects of curcumin.	Curcumin	42-50	mechanistic target of rapamycin kinase	Homo sapiens	62-66
21479462-6	2008	In this study, we demonstrate that curcumin (diferuloylmethane) abrogates OPN-induced VEGF expression and curbs OPN-induced VEGF-dependent breast tumor angiogenesis in vivo.	Curcumin	45-62	vascular endothelial growth factor A	Homo sapiens	86-90
21479462-6	2008	In this study, we demonstrate that curcumin (diferuloylmethane) abrogates OPN-induced VEGF expression and curbs OPN-induced VEGF-dependent breast tumor angiogenesis in vivo.	Curcumin	45-62	vascular endothelial growth factor A	Homo sapiens	124-128
21479462-7	2008	We also explore the fact that curcumin in combination with anti-VEGF or anti-neuropilin (NRP)-1 antibody exhibits enhanced anti-angiogenic activity compared to curcumin alone.	Curcumin	160-168	vascular endothelial growth factor A	Homo sapiens	64-68
21479462-8	2008	Our results indicate that curcumin suppresses OPN-induced VEGF expression and tumor angiogenesis, and suggest that this study may aid in the development of a curcumin-based OPN-targeted therapeutic approach to the control of breast tumor angiogenesis.	Curcumin	26-34	vascular endothelial growth factor A	Homo sapiens	58-62
18556656-3	2008	Time- and concentration-dependent inhibition of immunodetectable [(33)P]orthophosphate in UGTs and protein kinase Cepsilon (PKCepsilon), following treatment of LS180 cells with curcumin or the PKC inhibitor calphostin-C, suggested UGT phosphorylation is supported by active PKC(s).	Curcumin	177-185	protein kinase C alpha	Homo sapiens	124-127
18704882-3	2008	Previous studies have shown that curcumin reduces plasma LDL-C and has hypolipidemic and anti-atherosclerotic effects.	Curcumin	33-41	component of oligomeric golgi complex 2	Homo sapiens	57-62
18704882-7	2008	In HepG2/Insig2 cells, curcumin reversed the inhibition of LDL-R expression induced by Insig2 overexpression.	Curcumin	23-31	insulin induced gene 2	Homo sapiens	9-15
18704882-7	2008	In HepG2/Insig2 cells, curcumin reversed the inhibition of LDL-R expression induced by Insig2 overexpression.	Curcumin	23-31	insulin induced gene 2	Homo sapiens	87-93
18695518-0	2008	Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation.	Curcumin	31-39	beta-secretase 1	Homo sapiens	70-101
18695518-5	2008	Here, we demonstrate that naturally occurring compounds (-)-epigallocatechin-3-gallate and curcumin suppress beta amyloid-induced BACE-1 upregulation.	Curcumin	91-99	beta-secretase 1	Homo sapiens	130-136
18602917-1	2008	In this study, we showed that curcumin treatment resulted in activation of Chk1-mediated G2 checkpoint, which was associated with the induction of G2/M arrest and the resistance of cancer cells to curcumin-induced apoptosis.	Curcumin	30-38	checkpoint kinase 1	Homo sapiens	75-79
18602917-1	2008	In this study, we showed that curcumin treatment resulted in activation of Chk1-mediated G2 checkpoint, which was associated with the induction of G2/M arrest and the resistance of cancer cells to curcumin-induced apoptosis.	Curcumin	197-205	checkpoint kinase 1	Homo sapiens	75-79
18602917-2	2008	Further investigation revealed that inhibition of Chk1 significantly abrogated G2/M arrest and sensitized curcumin-resistant cells to apoptosis via upregulation of Bad and in turn the loss of mitochondrial membrane potential.	Curcumin	106-114	checkpoint kinase 1	Homo sapiens	50-54
18602917-3	2008	These results indicate that Chk1-mediated G2/M arrest may serve as a mechanism for curcumin resistance and Chk1 represents a potential target for the reversal of this resistance.	Curcumin	83-91	checkpoint kinase 1	Homo sapiens	28-32
18501560-8	2008	Moreover, pretreatment with p300 inhibitor (curcumin) also blocked IL-8 expression.	Curcumin	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	67-71
18450960-8	2008	The growth-inhibitory effect of curcumin was accompanied by decreased expression of cyclin D3 and ser 780 phosphorylation of retinoblastoma protein.	Curcumin	32-40	cyclin D3	Rattus norvegicus	84-93
18682687-0	2008	EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1.	Curcumin	14-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-87
18682687-5	2008	Treatment of MDA-MB231 breast and PC3 prostate cancer cells with EF24 or curcumin led to inhibition of HIF-1alpha protein levels and, consequently, inhibition of HIF transcriptional activity.	Curcumin	73-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-113
18682687-7	2008	We found that, while curcumin inhibited HIF-1alpha gene transcription, EF24 exerted its activity by inhibiting HIF-1alpha posttranscriptionally.	Curcumin	21-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-50
18593936-2	2008	In this study, 10 to 25 micromol/L curcumin inhibited 253JB-V and KU7 bladder cancer cell growth, and this was accompanied by induction of apoptosis and decreased expression of the proapoptotic protein survivin and the angiogenic proteins vascular endothelial growth factor (VEGF) and VEGF receptor 1 (VEGFR1).	Curcumin	35-43	vascular endothelial growth factor A	Homo sapiens	275-279
18249473-5	2008	Apart from insights in important molecular properties for CYP inhibition, the present results may also guide further design of curcumin analogues with less susceptibility to drug-drug interactions.	Curcumin	127-135	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	58-61
19086645-0	2008	[Curcumin inhibits growth, induces G1 arrest and apoptosis on human prostatic stromal cells by regulating Bcl-2/Bax].	Curcumin	1-9	BCL2 apoptosis regulator	Homo sapiens	106-111
19086645-0	2008	[Curcumin inhibits growth, induces G1 arrest and apoptosis on human prostatic stromal cells by regulating Bcl-2/Bax].	Curcumin	1-9	BCL2 associated X, apoptosis regulator	Homo sapiens	112-115
19086645-7	2008	CONCLUSION: Curcumin can induce apoptosis in human prostatic stromal cells by down-regulation of Bcl-2/Bax.	Curcumin	12-20	BCL2 apoptosis regulator	Homo sapiens	97-102
19086645-7	2008	CONCLUSION: Curcumin can induce apoptosis in human prostatic stromal cells by down-regulation of Bcl-2/Bax.	Curcumin	12-20	BCL2 associated X, apoptosis regulator	Homo sapiens	103-106
18628464-2	2008	We evaluated the clinical biological effects of curcumin (diferuloylmethane), a plant-derived dietary ingredient with potent nuclear factor-kappaB (NF-kappaB) and tumor inhibitory properties, against advanced pancreatic cancer.	Curcumin	48-56	nuclear factor kappa B subunit 1	Homo sapiens	148-157
18628464-2	2008	We evaluated the clinical biological effects of curcumin (diferuloylmethane), a plant-derived dietary ingredient with potent nuclear factor-kappaB (NF-kappaB) and tumor inhibitory properties, against advanced pancreatic cancer.	Curcumin	58-75	nuclear factor kappa B subunit 1	Homo sapiens	148-157
18628464-10	2008	Curcumin down-regulated expression of NF-kappaB, cyclooxygenase-2, and phosphorylated signal transducer and activator of transcription 3 in peripheral blood mononuclear cells from patients (most of whom had baseline levels considerably higher than those found in healthy volunteers).	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	38-47
18628464-10	2008	Curcumin down-regulated expression of NF-kappaB, cyclooxygenase-2, and phosphorylated signal transducer and activator of transcription 3 in peripheral blood mononuclear cells from patients (most of whom had baseline levels considerably higher than those found in healthy volunteers).	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	49-65
18628464-10	2008	Curcumin down-regulated expression of NF-kappaB, cyclooxygenase-2, and phosphorylated signal transducer and activator of transcription 3 in peripheral blood mononuclear cells from patients (most of whom had baseline levels considerably higher than those found in healthy volunteers).	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	86-136
18705752-0	2008	Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress.	Curcumin	0-8	C-C motif chemokine ligand 4	Rattus norvegicus	77-81
18705752-0	2008	Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	99-107
18705752-9	2008	Curcumin also partially reversed the fibrosis induced by CCl(4).	Curcumin	0-8	C-C motif chemokine ligand 4	Rattus norvegicus	57-63
18705752-10	2008	Curcumin was effective in preventing and reversing cirrhosis, probably by its ability of reducing TGF-beta expression.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	98-106
18660423-12	2008	In addition, curcumin significantly (P &lt; 0.001) decreased SDF-1alpha-induced HRECs migration and downregulated SDF-1alpha-induced expression of CXCR4, phospho-AKT, phospho-phosphatidylinositol-3-kinase (PI3-K), and eNOS.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	162-165
19112904-0	2008	[Curcumin inhibiting the expression of indoleamine 2,3-dioxygenase induced by IFN-gamma in cancer cells].	Curcumin	1-9	interferon gamma	Homo sapiens	78-87
19112904-1	2008	OBJECTIVE: To investigate the effect of curcumin on indoleamine 2, 3 -dioxygenase (IDO) expression induced by IFN-gamma in cancer cells.	Curcumin	40-48	interferon gamma	Homo sapiens	110-119
19112904-3	2008	The effects of curcumin on IDO expression induced by IFN-gamma in these cancer cells were demonstrated by Western blot.	Curcumin	15-23	interferon gamma	Homo sapiens	53-62
19112904-4	2008	The transcription of interferon responsive factor-1 (IRF-1), which was a key transcription factor regulating IDO expression, was analyzed by reverse transcription polymerase chain reaction (RT-PCR) under the treatment of curcumin.	Curcumin	221-229	interferon regulatory factor 1	Homo sapiens	21-51
19112904-4	2008	The transcription of interferon responsive factor-1 (IRF-1), which was a key transcription factor regulating IDO expression, was analyzed by reverse transcription polymerase chain reaction (RT-PCR) under the treatment of curcumin.	Curcumin	221-229	interferon regulatory factor 1	Homo sapiens	53-58
18565277-7	2008	RESULTS: The adhesion between thrombin-activated platelets and normal BMECs, and that of TNF-alpha-activated BMECs and normal platelets were significantly increased, and this increase could be inhibited by curcumin (30-240 micromol/L) in a concentration-dependant manner.	Curcumin	206-214	coagulation factor II, thrombin	Homo sapiens	30-38
18565277-7	2008	RESULTS: The adhesion between thrombin-activated platelets and normal BMECs, and that of TNF-alpha-activated BMECs and normal platelets were significantly increased, and this increase could be inhibited by curcumin (30-240 micromol/L) in a concentration-dependant manner.	Curcumin	206-214	tumor necrosis factor	Homo sapiens	89-98
18565277-8	2008	The platelets activated with thrombin and BMECs stimulated by TNF-alpha demonstrated an upregulated expressions of P-selectin and E-selectin, and this increase, when pretreated with curcumin for 30 min, could be restrained dose dependently.	Curcumin	182-190	coagulation factor II, thrombin	Homo sapiens	29-37
18565277-8	2008	The platelets activated with thrombin and BMECs stimulated by TNF-alpha demonstrated an upregulated expressions of P-selectin and E-selectin, and this increase, when pretreated with curcumin for 30 min, could be restrained dose dependently.	Curcumin	182-190	tumor necrosis factor	Homo sapiens	62-71
18565277-9	2008	Curcumin also inhibited the increase of the GPIIb/GPIIIa expression of thrombinactivated platelets in a concentration-dependent manner.	Curcumin	0-8	integrin subunit beta 3	Homo sapiens	50-56
18414057-7	2008	The expression of MDR-related genes mdr1, gst-pi and topo IIalpha, was altered by sulfinosine and curcumin.	Curcumin	98-106	ATP binding cassette subfamily B member 1	Homo sapiens	36-40
18414057-11	2008	Our results show that sulfinosine and curcumin overcome MDR in non-small cell lung carcinoma cell line (NSCLC), especially in combination despite the presence of a mutated p53 gene.	Curcumin	38-46	tumor protein p53	Homo sapiens	172-175
18593936-2	2008	In this study, 10 to 25 micromol/L curcumin inhibited 253JB-V and KU7 bladder cancer cell growth, and this was accompanied by induction of apoptosis and decreased expression of the proapoptotic protein survivin and the angiogenic proteins vascular endothelial growth factor (VEGF) and VEGF receptor 1 (VEGFR1).	Curcumin	35-43	fms related receptor tyrosine kinase 1	Homo sapiens	285-300
18593936-2	2008	In this study, 10 to 25 micromol/L curcumin inhibited 253JB-V and KU7 bladder cancer cell growth, and this was accompanied by induction of apoptosis and decreased expression of the proapoptotic protein survivin and the angiogenic proteins vascular endothelial growth factor (VEGF) and VEGF receptor 1 (VEGFR1).	Curcumin	35-43	fms related receptor tyrosine kinase 1	Homo sapiens	302-308
18593936-4	2008	The results show that curcumin induced proteasome-dependent down-regulation of Sp1, Sp3, and Sp4 in 253JB-V and KU7 cells.	Curcumin	22-30	Sp3 transcription factor	Homo sapiens	84-87
18593936-5	2008	Moreover, using RNA interference with small inhibitory RNAs for Sp1, Sp3, and Sp4, we observed that curcumin-dependent inhibition of nuclear factor kappaB (NF-kappaB)-dependent genes, such as bcl-2, survivin, and cyclin D1, was also due, in part, to loss of Sp proteins.	Curcumin	100-108	Sp3 transcription factor	Homo sapiens	69-72
18593936-5	2008	Moreover, using RNA interference with small inhibitory RNAs for Sp1, Sp3, and Sp4, we observed that curcumin-dependent inhibition of nuclear factor kappaB (NF-kappaB)-dependent genes, such as bcl-2, survivin, and cyclin D1, was also due, in part, to loss of Sp proteins.	Curcumin	100-108	BCL2 apoptosis regulator	Homo sapiens	192-197
18593936-6	2008	Curcumin also decreased bladder tumor growth in athymic nude mice bearing KU7 cells as xenografts and this was accompanied by decreased Sp1, Sp3, and Sp4 protein levels in tumors.	Curcumin	0-8	Sp3 transcription factor	Homo sapiens	141-144
18385293-3	2008	Curcumin (from turmeric) at 30 to 60 microM and 6-gingerol (from ginger) at 100 to 500 microM were observed to inhibit P-gp-mediated [(3)H]digoxin transport in L-MDR1 and Caco-2 cells.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	119-123
18385293-3	2008	Curcumin (from turmeric) at 30 to 60 microM and 6-gingerol (from ginger) at 100 to 500 microM were observed to inhibit P-gp-mediated [(3)H]digoxin transport in L-MDR1 and Caco-2 cells.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	162-166
18386790-0	2008	Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin"s lymphoma cells.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	117-122
18386790-4	2008	Curcumin is incorporated into H-RS cells and acts inhibiting both NF-kappaB and STAT3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1, survivin, c-myc and cyclin D1.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	195-200
18386790-4	2008	Curcumin is incorporated into H-RS cells and acts inhibiting both NF-kappaB and STAT3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1, survivin, c-myc and cyclin D1.	Curcumin	0-8	BCL2 like 1	Homo sapiens	202-208
18386790-3	2008	Based on the above information, we investigated the capacity of curcumin to inhibit NF-kappaB and STAT3 in H-RS cells, characterizing the functional consequences.	Curcumin	64-72	signal transducer and activator of transcription 3	Homo sapiens	98-103
18386790-4	2008	Curcumin is incorporated into H-RS cells and acts inhibiting both NF-kappaB and STAT3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1, survivin, c-myc and cyclin D1.	Curcumin	0-8	CASP8 and FADD like apoptosis regulator	Homo sapiens	210-215
18386790-6	2008	Furthermore, curcumin triggered cell death by apoptosis, as evidenced by the activation of caspase-3 and caspase-9, changes in nuclear morphology and phosphatidylserine translocation.	Curcumin	13-21	caspase 3	Homo sapiens	91-100
18386790-4	2008	Curcumin is incorporated into H-RS cells and acts inhibiting both NF-kappaB and STAT3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1, survivin, c-myc and cyclin D1.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	80-85
18601853-0	2008	[Effects of curcumin on secretion of adiponectin and interleukin-6 in human adipose tissues: an in vitro study].	Curcumin	12-20	adiponectin, C1Q and collagen domain containing	Homo sapiens	37-48
18417733-4	2008	In both the acute (LPS) and chronic inflammation (Tg2576), TC and curcumin similarly reduced interleukin-1beta.	Curcumin	66-74	interleukin 1 beta	Mus musculus	93-110
18588981-0	2008	Nrf2 regulates curcumin-induced aldose reductase expression indirectly via nuclear factor-kappaB.	Curcumin	15-23	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
18588981-0	2008	Nrf2 regulates curcumin-induced aldose reductase expression indirectly via nuclear factor-kappaB.	Curcumin	15-23	aldo-keto reductase family 1 member B	Homo sapiens	32-48
18588981-2	2008	Curcumin, an herb-derived polyphenolic compound, elicited an increase in the expression and promoter activity of the AR gene in a nuclear factor-erythroid 2-related factor 2 (Nrf2)-dependent manner.	Curcumin	0-8	aldo-keto reductase family 1 member B	Homo sapiens	117-119
18588981-2	2008	Curcumin, an herb-derived polyphenolic compound, elicited an increase in the expression and promoter activity of the AR gene in a nuclear factor-erythroid 2-related factor 2 (Nrf2)-dependent manner.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	130-173
18588981-2	2008	Curcumin, an herb-derived polyphenolic compound, elicited an increase in the expression and promoter activity of the AR gene in a nuclear factor-erythroid 2-related factor 2 (Nrf2)-dependent manner.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	175-179
18588981-3	2008	Small interfering RNA (siRNA) against p65 or BAY11-7082, an inhibitor of NF-kappaB, significantly suppressed the curcumin and/or Nrf2-induced increase in expression levels and promoter activity of the AR gene.	Curcumin	113-121	nuclear factor kappa B subunit 1	Homo sapiens	73-82
18588981-3	2008	Small interfering RNA (siRNA) against p65 or BAY11-7082, an inhibitor of NF-kappaB, significantly suppressed the curcumin and/or Nrf2-induced increase in expression levels and promoter activity of the AR gene.	Curcumin	113-121	aldo-keto reductase family 1 member B	Homo sapiens	201-203
18588981-4	2008	BAY11-7082 or siRNA against p65 also attenuated the curcumin-induced increase in the promoter activity of the wild type AR-ORE(wt) gene, but not that of the mutated AR-ORE(mt), indicating that the ORE is essential for the response to NF-kappaB.	Curcumin	52-60	aldo-keto reductase family 1 member B	Homo sapiens	120-122
18588981-4	2008	BAY11-7082 or siRNA against p65 also attenuated the curcumin-induced increase in the promoter activity of the wild type AR-ORE(wt) gene, but not that of the mutated AR-ORE(mt), indicating that the ORE is essential for the response to NF-kappaB.	Curcumin	52-60	nuclear factor kappa B subunit 1	Homo sapiens	234-243
18588981-5	2008	The expression of p65, the promoter activity and DNA binding activity of NF-kappaB were enhanced in the presence of curcumin in cells that were transfected with Nrf2 compared to those treated with curcumin alone.	Curcumin	116-124	nuclear factor kappa B subunit 1	Homo sapiens	73-82
18588981-5	2008	The expression of p65, the promoter activity and DNA binding activity of NF-kappaB were enhanced in the presence of curcumin in cells that were transfected with Nrf2 compared to those treated with curcumin alone.	Curcumin	116-124	NFE2 like bZIP transcription factor 2	Homo sapiens	161-165
18588981-5	2008	The expression of p65, the promoter activity and DNA binding activity of NF-kappaB were enhanced in the presence of curcumin in cells that were transfected with Nrf2 compared to those treated with curcumin alone.	Curcumin	197-205	nuclear factor kappa B subunit 1	Homo sapiens	73-82
18588981-5	2008	The expression of p65, the promoter activity and DNA binding activity of NF-kappaB were enhanced in the presence of curcumin in cells that were transfected with Nrf2 compared to those treated with curcumin alone.	Curcumin	197-205	NFE2 like bZIP transcription factor 2	Homo sapiens	161-165
18601853-0	2008	[Effects of curcumin on secretion of adiponectin and interleukin-6 in human adipose tissues: an in vitro study].	Curcumin	12-20	interleukin 6	Homo sapiens	53-66
18601853-1	2008	OBJECTIVE: To investigate the effects of different concentrations of curcumin on secretion of adiponectin (APN) and interleukin-6 (IL-6) in human adipose tissues cultivated in vitro.	Curcumin	69-77	adiponectin, C1Q and collagen domain containing	Homo sapiens	94-105
18601853-5	2008	RESULTS: Compared with the blank control group, the content of APN in the adipose tissue culture medium was increased by 100 microg/ml curcumin (P&lt;0.05) after 6-hour culture, and the content of IL-6 was significantly decreased by 100 microg/ml curcumin after 6- and 24-hour culture (P&lt;0.05).	Curcumin	135-143	adiponectin, C1Q and collagen domain containing	Homo sapiens	63-66
18601853-5	2008	RESULTS: Compared with the blank control group, the content of APN in the adipose tissue culture medium was increased by 100 microg/ml curcumin (P&lt;0.05) after 6-hour culture, and the content of IL-6 was significantly decreased by 100 microg/ml curcumin after 6- and 24-hour culture (P&lt;0.05).	Curcumin	247-255	adiponectin, C1Q and collagen domain containing	Homo sapiens	63-66
18601853-6	2008	CONCLUSION: 100 microg/ml curcumin can increase APN secretion and decrease IL-6 secretion in human adipose tissues cultivated in vitro.	Curcumin	26-34	adiponectin, C1Q and collagen domain containing	Homo sapiens	48-51
18601853-6	2008	CONCLUSION: 100 microg/ml curcumin can increase APN secretion and decrease IL-6 secretion in human adipose tissues cultivated in vitro.	Curcumin	26-34	interleukin 6	Homo sapiens	75-79
18397880-6	2008	The increase in eNOS mRNA caused by shear was completely blocked by pharmacological inhibition of p300/HAT activity with curcumin or by p300 small interfering RNA.	Curcumin	121-129	nitric oxide synthase 3	Homo sapiens	16-20
18460899-2	2008	In this report, we evaluated the efficacy of curcumin, a potent NF-kappaB inhibitor, in mdx mice, a mouse model of DMD.	Curcumin	45-53	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	64-73
18460899-6	2008	We also found that levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and inducible nitric oxide synthase (iNOS) in the mdx mice were decreased by curcumin administration.	Curcumin	177-185	tumor necrosis factor	Mus musculus	29-56
18439772-7	2008	Interestingly, contrary to Curcumas, curcumin treatment inhibited the activity of P-gp with a decrease in P-gp protein and MDR1 mRNA expression levels.	Curcumin	37-45	ATP binding cassette subfamily B member 1	Homo sapiens	123-127
18342436-4	2008	The anti-apoptotic Bcl-2 and Survivin protein was downregulated by the curcumin treatment together with enhancement of the Bax and p53 expression.	Curcumin	71-79	BCL2 apoptosis regulator	Homo sapiens	19-24
18460899-6	2008	We also found that levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and inducible nitric oxide synthase (iNOS) in the mdx mice were decreased by curcumin administration.	Curcumin	177-185	tumor necrosis factor	Mus musculus	58-67
18598162-7	2008	After 8 weeks, supplementation with curcumin and/or saikosaponin a significantly decreased plasma alanine aminotransferase and aspartate aminotransferase activities, as well as plasma and hepatic cholesterol and triglyceride levels.	Curcumin	36-44	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	127-153
18460899-6	2008	We also found that levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and inducible nitric oxide synthase (iNOS) in the mdx mice were decreased by curcumin administration.	Curcumin	177-185	interleukin 1 beta	Mus musculus	70-88
18460899-6	2008	We also found that levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and inducible nitric oxide synthase (iNOS) in the mdx mice were decreased by curcumin administration.	Curcumin	177-185	interleukin 1 beta	Mus musculus	90-98
18460899-6	2008	We also found that levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and inducible nitric oxide synthase (iNOS) in the mdx mice were decreased by curcumin administration.	Curcumin	177-185	nitric oxide synthase 2, inducible	Mus musculus	104-135
18460899-8	2008	We thus conclude that curcumin is effective in the therapy of muscular dystrophy in mdx mice, and that the mechanism may involve inhibition of NF-kappaB activity.	Curcumin	22-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-152
18549505-14	2008	CONCLUSION: Curcumin and resveratrol are able to inhibit TNFalpha-activated NF-kappaB signaling in adipocytes and as a result significantly reduce cytokine expression.	Curcumin	12-20	tumor necrosis factor	Homo sapiens	57-65
18324353-3	2008	The pleiotropic activities of curcumin derive from its complex chemistry as well as its ability to influence multiple signaling pathways, including survival pathways such as those regulated by NF-kappaB, Akt, and growth factors; cytoprotective pathways dependent on Nrf2; and metastatic and angiogenic pathways.	Curcumin	30-38	AKT serine/threonine kinase 1	Homo sapiens	204-207
18324353-3	2008	The pleiotropic activities of curcumin derive from its complex chemistry as well as its ability to influence multiple signaling pathways, including survival pathways such as those regulated by NF-kappaB, Akt, and growth factors; cytoprotective pathways dependent on Nrf2; and metastatic and angiogenic pathways.	Curcumin	30-38	NFE2 like bZIP transcription factor 2	Homo sapiens	266-270
18423603-9	2008	Western blot analysis showed that cell death in curcumin-treated cultures of p21(+/+) and p21(-/-) HCT-116 cells was associated with a reduction in pro-caspase-3 and PARP-1 cleavage, which are indicative of apoptosis.	Curcumin	48-56	caspase 3	Homo sapiens	148-161
18423603-9	2008	Western blot analysis showed that cell death in curcumin-treated cultures of p21(+/+) and p21(-/-) HCT-116 cells was associated with a reduction in pro-caspase-3 and PARP-1 cleavage, which are indicative of apoptosis.	Curcumin	48-56	poly(ADP-ribose) polymerase 1	Homo sapiens	166-172
18357586-2	2008	Herein, we show that Curcumin dose dependently induced HO-1 expression and HO-1 activity through the activation of PKCalpha, PKCdelta/ERK1/2, p38alpha, and PI3-kinase.	Curcumin	21-29	protein kinase C alpha	Homo sapiens	115-123
18357586-2	2008	Herein, we show that Curcumin dose dependently induced HO-1 expression and HO-1 activity through the activation of PKCalpha, PKCdelta/ERK1/2, p38alpha, and PI3-kinase.	Curcumin	21-29	mitogen-activated protein kinase 3	Homo sapiens	134-140
18357586-2	2008	Herein, we show that Curcumin dose dependently induced HO-1 expression and HO-1 activity through the activation of PKCalpha, PKCdelta/ERK1/2, p38alpha, and PI3-kinase.	Curcumin	21-29	mitogen-activated protein kinase 14	Homo sapiens	142-150
18357586-3	2008	In addition, H2O2 release is essential for Curcumin-mediated ERK1/2 and p38 phosphorylation and HO-1 expression.	Curcumin	43-51	mitogen-activated protein kinase 3	Homo sapiens	61-67
18357586-3	2008	In addition, H2O2 release is essential for Curcumin-mediated ERK1/2 and p38 phosphorylation and HO-1 expression.	Curcumin	43-51	mitogen-activated protein kinase 1	Homo sapiens	72-75
18549505-13	2008	Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM).	Curcumin	0-8	tumor necrosis factor	Homo sapiens	97-106
18549505-13	2008	Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM).	Curcumin	0-8	interleukin 1 beta	Homo sapiens	108-116
18549505-13	2008	Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM).	Curcumin	0-8	interleukin 6	Homo sapiens	118-122
18549505-13	2008	Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM).	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-133
18549505-13	2008	Curcumin and resveratrol treatment inhibited NF-kappaB activation and resulted in a reduction of TNF-alpha, IL-1beta, IL-6, and COX-2 gene expression (IC50 = 2 muM) and a reduction of secreted IL-6 and PGE2 (IC50 ~ 20 muM).	Curcumin	0-8	interleukin 6	Homo sapiens	193-197
18570726-8	2008	CONCLUSION: Curcumin inhibits the phosphorylation of IkappaBalpha, leading to suppression of proliferation, induction of apoptosis and an increase of the sensitivity of ESCC cell lines towards 5-FU.	Curcumin	12-20	NFKB inhibitor alpha	Homo sapiens	53-65
18598162-0	2008	Curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats.	Curcumin	0-8	C-C motif chemokine ligand 4	Rattus norvegicus	86-90
18598162-10	2008	Therefore, supplementation with curcumin and/or saikosaponin a protects against CCl(4)-induced liver injury by attenuating hepatic lipids and lipid peroxidation and enhancing antioxidant defense.	Curcumin	32-40	C-C motif chemokine ligand 4	Rattus norvegicus	80-86
18332871-6	2008	Further experiments observed that curcumin dose dependently reduced gene expression of PDGF and EGF receptors (ie, PDGF-betaR and EGFR), which required PPARgamma activation.	Curcumin	34-42	epidermal growth factor receptor	Homo sapiens	130-134
18321868-5	2008	Although curcumin alone did not alter the basal levels of aryl hydrocarbon receptor (AhR), it significantly decreased the B[a]P-induced AhR protein levels, its phosphorylation, nuclear translocation and subsequent binding to DNA, thereby decreasing the transactivation of CYP1A.	Curcumin	9-17	aryl-hydrocarbon receptor	Mus musculus	85-88
18321868-5	2008	Although curcumin alone did not alter the basal levels of aryl hydrocarbon receptor (AhR), it significantly decreased the B[a]P-induced AhR protein levels, its phosphorylation, nuclear translocation and subsequent binding to DNA, thereby decreasing the transactivation of CYP1A.	Curcumin	9-17	aryl-hydrocarbon receptor	Mus musculus	136-139
18321868-6	2008	Dietary curcumin led to increase in NF-E2-related factor-2 (Nrf2) protein levels and enhanced its nuclear translocation in liver and lungs of mice as compared with controls.	Curcumin	8-16	nuclear factor, erythroid derived 2, like 2	Mus musculus	36-58
18321868-6	2008	Dietary curcumin led to increase in NF-E2-related factor-2 (Nrf2) protein levels and enhanced its nuclear translocation in liver and lungs of mice as compared with controls.	Curcumin	8-16	nuclear factor, erythroid derived 2, like 2	Mus musculus	60-64
18321868-7	2008	Additionally, increased binding of Nrf2 to antioxidant response element occurred in nuclear extracts from liver and lungs of mice pretreated with dietary curcumin.	Curcumin	154-162	nuclear factor, erythroid derived 2, like 2	Mus musculus	35-39
17922140-9	2008	Treatment of these cells with Stat3 siRNA or curcumin, which inhibited Stat3 phosphorylation, resulted in reduction of the NNMT level.	Curcumin	45-53	signal transducer and activator of transcription 3	Homo sapiens	71-76
18467956-0	2008	Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cells.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	43-47
18467956-4	2008	The objective of this study was to examine whether the polyphenol compound curcumin has the capacity to block progestin-induced secretion of VEGF from T47-D human breast cancer cells.	Curcumin	75-83	vascular endothelial growth factor A	Homo sapiens	141-145
18467956-6	2008	RESULTS: Curcumin (0.001-10 microM for 18 h) reduced medroxyprogesterone acetate (MPA)-induced secretion of VEGF from T47-D cells in a dose-dependent manner.	Curcumin	9-17	vascular endothelial growth factor A	Homo sapiens	108-112
18467956-9	2008	Curcumin may therefore provide a clinically useful tool for the suppression of MPA-induced elaboration of VEGF by tumor cells.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	106-110
18252805-7	2008	The antioxidant compound N-acetylcysteine blocked the curcumin-induced increased reactive oxygen species (ROS), sustained activation of ERK1/2, and decreased survival after IR in HeLa cells, implicating a ROS-dependent mechanism for curcumin radiosensitivity.	Curcumin	54-62	mitogen-activated protein kinase 3	Homo sapiens	136-142
18252805-9	2008	Together, these results suggest a novel mechanism for curcumin-mediated radiosensitization involving increased ROS and ERK1/2 activation and suggest that curcumin application (either systemically or topically) may be an effective radiation modifying modality in the treatment of cervical cancer.	Curcumin	54-62	mitogen-activated protein kinase 3	Homo sapiens	119-125
18357586-4	2008	Further, Curcumin inhibited LPS-induced IL-1 and IL-6 secretion and blockage of HO-1 expression/activity by HO-1 siRNA or HO-1 inhibitor, SnPP reversed the inhibitory effects of Curcumin on cytokines secretion.	Curcumin	9-17	interleukin 6	Homo sapiens	49-53
18377885-3	2008	Hyperthyroidism induced elevation in serum aspartate aminotransferase and alanine aminotransferase activities were reduced significantly in response to vitamin E and curcumin treatment.	Curcumin	166-174	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	43-69
18420184-0	2008	Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB.	Curcumin	0-8	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	153-157
18420184-9	2008	Taken together, these results suggest that the neuroprotective effect of curcumin might be mediated via BDNF/TrkB signaling pathway.	Curcumin	73-81	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	109-113
18701050-11	2008	Curcumin also attenuated the neuropathological changes in the hippocampus and inhibited apoptosis accompanied by an increase in Bcl-2 level (P < 0.05), but the activity of Bax did not change (P > 0.05).	Curcumin	0-8	B cell leukemia/lymphoma 2	Mus musculus	128-133
18701050-15	2008	Curcumin protected cells by increasing Bcl-2 level (P < 0.05), but the level of Bax did not change (P > 0.05).	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	39-44
18430363-7	2008	d(-1 )curcumin to apoE-/- mice for 4 months induced a 50% reduction of atherosclerotic lesions and yielded a 5- fold increase in the caveolin-1 expression level as compared to the model group.	Curcumin	6-14	apolipoprotein E	Mus musculus	18-22
18098290-7	2008	Curcumin treatment significantly decreased tumor protein levels of EGFR and Akt, however the expression of these proteins was not further decreased following combination treatment.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	76-79
18394691-7	2008	Suppression of degranulation and secretion of TNF-alpha and IL-4 was apparent at concentrations as low as 3 micromol/L curcumin in activated mast cells.	Curcumin	119-127	tumor necrosis factor	Mus musculus	46-55
18315570-6	2008	Moreover, IL-1beta-induced proMMP-9 expression was blocked by pre-treatment with curcumin (a p300 inhibitor).	Curcumin	81-89	interleukin 1 beta	Rattus norvegicus	10-18
18332871-0	2008	Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells.	Curcumin	66-74	peroxisome proliferator activated receptor gamma	Homo sapiens	14-62
18332871-2	2008	We previously reported that curcumin, the yellow pigment in curry, interrupted PDGF and EGF signaling, stimulated PPARgamma gene expression, and enhanced its activity, leading to inhibition of cell proliferation of activated HSC in vitro and in vivo.	Curcumin	28-36	peroxisome proliferator activated receptor gamma	Homo sapiens	114-123
18332871-4	2008	We hypothesized that the enhancement of PPARgamma activity by curcumin might result in the interruption of PDGF and EGF signaling.	Curcumin	62-70	peroxisome proliferator activated receptor gamma	Homo sapiens	40-49
18332871-6	2008	Further experiments observed that curcumin dose dependently reduced gene expression of PDGF and EGF receptors (ie, PDGF-betaR and EGFR), which required PPARgamma activation.	Curcumin	34-42	peroxisome proliferator activated receptor gamma	Homo sapiens	152-161
18332871-8	2008	In addition, curcumin reduced the phosphorylation levels of PDGF-betaR and EGFR, as well as their downstream signaling cascades, including ERK1/2 and JNK1/2.	Curcumin	13-21	epidermal growth factor receptor	Homo sapiens	75-79
18332871-8	2008	In addition, curcumin reduced the phosphorylation levels of PDGF-betaR and EGFR, as well as their downstream signaling cascades, including ERK1/2 and JNK1/2.	Curcumin	13-21	mitogen-activated protein kinase 3	Homo sapiens	139-145
18332871-8	2008	In addition, curcumin reduced the phosphorylation levels of PDGF-betaR and EGFR, as well as their downstream signaling cascades, including ERK1/2 and JNK1/2.	Curcumin	13-21	mitogen-activated protein kinase 8	Homo sapiens	150-156
18332871-10	2008	De novo synthesis of glutathione was required for curcumin to suppress pdgf-betar and egfr expression in activated HSCs.	Curcumin	50-58	epidermal growth factor receptor	Homo sapiens	86-90
18332871-11	2008	Our results collectively demonstrated that enhancement of PPARgamma activity by curcumin interrupted PDGF and EGF signaling in activated HSCs by reducing the phosphorylation levels of PDGF-betaR and EGFR, and by suppressing the receptor gene expression.	Curcumin	80-88	peroxisome proliferator activated receptor gamma	Homo sapiens	58-67
18332871-11	2008	Our results collectively demonstrated that enhancement of PPARgamma activity by curcumin interrupted PDGF and EGF signaling in activated HSCs by reducing the phosphorylation levels of PDGF-betaR and EGFR, and by suppressing the receptor gene expression.	Curcumin	80-88	epidermal growth factor receptor	Homo sapiens	199-203
18646516-9	2008	When AP-1 activities were inhibited by curcumin, overexpression of p53 induced by B(a)P was not markedly changed.	Curcumin	39-47	tumor protein p53	Homo sapiens	67-70
18182168-6	2008	LPS-induced VCAM-1 expression was also blocked by pretreatment with curcumin (a p300 inhibitor) or transfection with p300 siRNA.	Curcumin	68-76	vascular cell adhesion molecule 1	Homo sapiens	12-18
18727865-12	2008	The TGF-beta(1) mRNA expression in the curcumin treated group was 0.61 +/- 0.09 and 0.48 +/- 0.16 respectively on the 21(st) and 28(th) day after bleomycin administration (P &lt; 0.05).	Curcumin	39-47	transforming growth factor, beta 1	Rattus norvegicus	4-15
18727865-14	2008	CONCLUSION: Curcumin could suppress BLM-induced pulmonary fibrosis in rats at the fibrosing stage, with the possible mechanism of inhibiting the synthesis and deposition of type I collagen protein and depressing the overexpression of TGF-beta(1) mRNA.	Curcumin	12-20	transforming growth factor, beta 1	Rattus norvegicus	234-245
18305409-0	2008	Curcumin inhibits NFkappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	18-26
18191976-2	2008	Curcumin is known to inhibit the histone acetyltransferase activity of the transcriptional coactivator proteins p300 and CBP, which are recruited to the immediate early (IE) gene promoters of herpes simplex virus type 1 (HSV-1) by the viral transactivator protein VP16.	Curcumin	0-8	CREB binding protein	Homo sapiens	121-124
18189141-2	2008	Curcumin, a constituent of the Indian spice Turmeric is structurally similar to Congo Red and has been demonstrated to bind Abeta amyloid and prevent further oligomerization of Abeta monomers onto growing amyloid beta-sheets.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	124-129
18305409-6	2008	Pre-treating the cells either with curcumin or SN50 significantly suppressed the radiation induced NFkappaB.	Curcumin	35-43	nuclear factor kappa B subunit 1	Homo sapiens	99-107
17999991-0	2008	Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	90-98
17999991-2	2008	Curcumin acts through the inhibition of phosphorylation of the inhibitor of kappa B (IkappaB), which in turn reduces the nuclear translocation of nuclear factor kappa B (NFkappaB), an inflammation- and cell survival-related transcription factor.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	146-168
17999991-2	2008	Curcumin acts through the inhibition of phosphorylation of the inhibitor of kappa B (IkappaB), which in turn reduces the nuclear translocation of nuclear factor kappa B (NFkappaB), an inflammation- and cell survival-related transcription factor.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	170-178
18305409-10	2008	These results suggest that curcumin is a potent radiosensitizer and may act by overcoming the effects of radiation-induced NFkappaB mediated pro-survival gene expression in neuroblastoma.	Curcumin	27-35	nuclear factor kappa B subunit 1	Homo sapiens	123-131
18006204-0	2008	Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	77-81
18381954-0	2008	Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	100-121
18381954-2	2008	Because curcumin, a component of turmeric (Curcuma longa), has been shown to suppress NF-kappaB activation, whether it can sensitize the colorectal cancer to gamma-radiation was investigated in colorectal cancer xenografts in nude mice.	Curcumin	8-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-95
18381954-8	2008	Moreover, curcumin suppressed NF-kappaB activity and the expression of NF-kappaB-regulated gene products (cyclin D1, c-myc, Bcl-2, Bcl-xL, cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase-9, and vascular endothelial growth factor), many of which were induced by radiation therapy and mediate radioresistance.	Curcumin	10-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	30-39
18381954-8	2008	Moreover, curcumin suppressed NF-kappaB activity and the expression of NF-kappaB-regulated gene products (cyclin D1, c-myc, Bcl-2, Bcl-xL, cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase-9, and vascular endothelial growth factor), many of which were induced by radiation therapy and mediate radioresistance.	Curcumin	10-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-80
18381954-8	2008	Moreover, curcumin suppressed NF-kappaB activity and the expression of NF-kappaB-regulated gene products (cyclin D1, c-myc, Bcl-2, Bcl-xL, cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase-9, and vascular endothelial growth factor), many of which were induced by radiation therapy and mediate radioresistance.	Curcumin	10-18	B cell leukemia/lymphoma 2	Mus musculus	124-129
18381954-10	2008	CONCLUSION: Collectively, our results suggest that curcumin potentiates the antitumor effects of radiation therapy in colorectal cancer by suppressing NF-kappaB and NF-kappaB-regulated gene products, leading to inhibition of proliferation and angiogenesis.	Curcumin	51-59	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	151-160
18381954-10	2008	CONCLUSION: Collectively, our results suggest that curcumin potentiates the antitumor effects of radiation therapy in colorectal cancer by suppressing NF-kappaB and NF-kappaB-regulated gene products, leading to inhibition of proliferation and angiogenesis.	Curcumin	51-59	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	165-174
18006204-8	2008	Curcumin administration resulted in enhanced nuclear translocation and ARE-binding of Nrf2.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	86-90
18408903-0	2008	Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson"s disease induced by MPTP neurodegeneration in mice.	Curcumin	64-72	monoamine oxidase B	Mus musculus	14-33
18408903-6	2008	The results showed that curcumin and tetrahydrocurcumin reversed the MPTP induced depletion of DA and DOPAC which may in part be due to inhibition of MAO-B activity.	Curcumin	24-32	monoamine oxidase B	Mus musculus	150-155
18316600-2	2008	Curcumin inhibits cancer cell proliferation in part by suppressing cyclin D1 and inducing expression of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1).	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	142-145
18370854-4	2008	The potentially adverse sequelae of curcumin"s effects on proapoptotic genes, particularly p53, represent a cause for current debate.	Curcumin	36-44	tumor protein p53	Homo sapiens	91-94
18316600-0	2008	p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression.	Curcumin	28-36	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-3
18507010-5	2008	The inhibitory effect of curcumin on nuclear factor kappa B (NF-kappaB) activation in the cells was clearly observed, but that of tetrahydrocurcumin was incomplete even at a concentration of 20 microM.	Curcumin	25-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	37-59
18507010-5	2008	The inhibitory effect of curcumin on nuclear factor kappa B (NF-kappaB) activation in the cells was clearly observed, but that of tetrahydrocurcumin was incomplete even at a concentration of 20 microM.	Curcumin	25-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	61-70
18316600-0	2008	p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression.	Curcumin	28-36	cyclin dependent kinase inhibitor 1A	Homo sapiens	4-8
18316600-2	2008	Curcumin inhibits cancer cell proliferation in part by suppressing cyclin D1 and inducing expression of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1).	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	146-150
18316600-0	2008	p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression.	Curcumin	28-36	cyclin dependent kinase inhibitor 1A	Homo sapiens	9-13
18316600-2	2008	Curcumin inhibits cancer cell proliferation in part by suppressing cyclin D1 and inducing expression of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1).	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	151-155
18316600-3	2008	Both p53-dependent and p53-independent mechanisms regulate p21(Waf1/Cip1) expression, but the mechanism by which curcumin regulates p21(Waf1/Cip1) expression remains unknown.	Curcumin	113-121	cyclin dependent kinase inhibitor 1A	Homo sapiens	132-135
18316600-3	2008	Both p53-dependent and p53-independent mechanisms regulate p21(Waf1/Cip1) expression, but the mechanism by which curcumin regulates p21(Waf1/Cip1) expression remains unknown.	Curcumin	113-121	cyclin dependent kinase inhibitor 1A	Homo sapiens	136-140
18316600-3	2008	Both p53-dependent and p53-independent mechanisms regulate p21(Waf1/Cip1) expression, but the mechanism by which curcumin regulates p21(Waf1/Cip1) expression remains unknown.	Curcumin	113-121	cyclin dependent kinase inhibitor 1A	Homo sapiens	141-145
18316600-4	2008	Here, we report that transcription of the p21(Waf1/Cip1) gene is activated by early growth response-1 (Egr-1) independently of p53 in response to curcumin treatment in U-87MG human glioblastoma cells.	Curcumin	146-154	cyclin dependent kinase inhibitor 1A	Homo sapiens	42-45
18316600-4	2008	Here, we report that transcription of the p21(Waf1/Cip1) gene is activated by early growth response-1 (Egr-1) independently of p53 in response to curcumin treatment in U-87MG human glioblastoma cells.	Curcumin	146-154	cyclin dependent kinase inhibitor 1A	Homo sapiens	46-50
18316600-4	2008	Here, we report that transcription of the p21(Waf1/Cip1) gene is activated by early growth response-1 (Egr-1) independently of p53 in response to curcumin treatment in U-87MG human glioblastoma cells.	Curcumin	146-154	cyclin dependent kinase inhibitor 1A	Homo sapiens	51-55
18316600-6	2008	Egr-1 expression is induced by curcumin through extracellular signal-regulated kinase (ERK) and c-Jun NH(2)-terminal kinase (JNK), but not the p38, mitogen-activated protein kinase (MAPK) pathways, which mediate the transactivation of Elk-1.	Curcumin	31-39	mitogen-activated protein kinase 1	Homo sapiens	48-85
18316600-6	2008	Egr-1 expression is induced by curcumin through extracellular signal-regulated kinase (ERK) and c-Jun NH(2)-terminal kinase (JNK), but not the p38, mitogen-activated protein kinase (MAPK) pathways, which mediate the transactivation of Elk-1.	Curcumin	31-39	mitogen-activated protein kinase 1	Homo sapiens	87-90
18316600-6	2008	Egr-1 expression is induced by curcumin through extracellular signal-regulated kinase (ERK) and c-Jun NH(2)-terminal kinase (JNK), but not the p38, mitogen-activated protein kinase (MAPK) pathways, which mediate the transactivation of Elk-1.	Curcumin	31-39	mitogen-activated protein kinase 8	Homo sapiens	96-123
18316600-6	2008	Egr-1 expression is induced by curcumin through extracellular signal-regulated kinase (ERK) and c-Jun NH(2)-terminal kinase (JNK), but not the p38, mitogen-activated protein kinase (MAPK) pathways, which mediate the transactivation of Elk-1.	Curcumin	31-39	mitogen-activated protein kinase 8	Homo sapiens	125-128
18316600-7	2008	Transient expression of Egr-1 enhanced curcumin-induced p21(Waf1/Cip1) promoter activity, whereas suppression of Egr-1 expression by small interfering RNA abrogated the ability of curcumin to induce p21(Waf1/Cip1) promoter activity.	Curcumin	39-47	cyclin dependent kinase inhibitor 1A	Homo sapiens	56-59
18316600-7	2008	Transient expression of Egr-1 enhanced curcumin-induced p21(Waf1/Cip1) promoter activity, whereas suppression of Egr-1 expression by small interfering RNA abrogated the ability of curcumin to induce p21(Waf1/Cip1) promoter activity.	Curcumin	39-47	cyclin dependent kinase inhibitor 1A	Homo sapiens	60-64
18316600-7	2008	Transient expression of Egr-1 enhanced curcumin-induced p21(Waf1/Cip1) promoter activity, whereas suppression of Egr-1 expression by small interfering RNA abrogated the ability of curcumin to induce p21(Waf1/Cip1) promoter activity.	Curcumin	39-47	cyclin dependent kinase inhibitor 1A	Homo sapiens	65-69
18316600-7	2008	Transient expression of Egr-1 enhanced curcumin-induced p21(Waf1/Cip1) promoter activity, whereas suppression of Egr-1 expression by small interfering RNA abrogated the ability of curcumin to induce p21(Waf1/Cip1) promoter activity.	Curcumin	180-188	cyclin dependent kinase inhibitor 1A	Homo sapiens	199-202
18316600-7	2008	Transient expression of Egr-1 enhanced curcumin-induced p21(Waf1/Cip1) promoter activity, whereas suppression of Egr-1 expression by small interfering RNA abrogated the ability of curcumin to induce p21(Waf1/Cip1) promoter activity.	Curcumin	180-188	cyclin dependent kinase inhibitor 1A	Homo sapiens	203-207
18316600-7	2008	Transient expression of Egr-1 enhanced curcumin-induced p21(Waf1/Cip1) promoter activity, whereas suppression of Egr-1 expression by small interfering RNA abrogated the ability of curcumin to induce p21(Waf1/Cip1) promoter activity.	Curcumin	180-188	cyclin dependent kinase inhibitor 1A	Homo sapiens	208-212
18316600-8	2008	In addition, stable knockdown of Egr-1 expression in U-87MG cells suppressed curcumin-induced p21 expression.	Curcumin	77-85	cyclin dependent kinase inhibitor 1A	Homo sapiens	94-97
18316600-9	2008	Our results indicate that ERK and JNK MAPK/Elk-1/Egr-1 signal cascade is required for p53-independent transcriptional activation of p21(Waf1/Cip1) in response to curcumin in U-87MG human glioblastoma cells.	Curcumin	162-170	mitogen-activated protein kinase 1	Homo sapiens	26-29
18316600-9	2008	Our results indicate that ERK and JNK MAPK/Elk-1/Egr-1 signal cascade is required for p53-independent transcriptional activation of p21(Waf1/Cip1) in response to curcumin in U-87MG human glioblastoma cells.	Curcumin	162-170	mitogen-activated protein kinase 8	Homo sapiens	34-37
18316600-9	2008	Our results indicate that ERK and JNK MAPK/Elk-1/Egr-1 signal cascade is required for p53-independent transcriptional activation of p21(Waf1/Cip1) in response to curcumin in U-87MG human glioblastoma cells.	Curcumin	162-170	tumor protein p53	Homo sapiens	86-89
18316600-9	2008	Our results indicate that ERK and JNK MAPK/Elk-1/Egr-1 signal cascade is required for p53-independent transcriptional activation of p21(Waf1/Cip1) in response to curcumin in U-87MG human glioblastoma cells.	Curcumin	162-170	cyclin dependent kinase inhibitor 1A	Homo sapiens	132-135
18316600-9	2008	Our results indicate that ERK and JNK MAPK/Elk-1/Egr-1 signal cascade is required for p53-independent transcriptional activation of p21(Waf1/Cip1) in response to curcumin in U-87MG human glioblastoma cells.	Curcumin	162-170	cyclin dependent kinase inhibitor 1A	Homo sapiens	136-140
18316600-9	2008	Our results indicate that ERK and JNK MAPK/Elk-1/Egr-1 signal cascade is required for p53-independent transcriptional activation of p21(Waf1/Cip1) in response to curcumin in U-87MG human glioblastoma cells.	Curcumin	162-170	cyclin dependent kinase inhibitor 1A	Homo sapiens	141-145
17879958-4	2008	We show that curcumin, an important inhibitor of CSN-associated kinases, can downregulate not only CSN5 but also MDM2, which results in p53 stabilization.	Curcumin	13-21	tumor protein p53	Homo sapiens	136-139
18321195-13	2008	CONCLUSION: We found that curcumin decreased the expression of iNOS, p65, and serum nitric oxide levels, and helped prevent interstitial, glomerular, tubular epithelial, and endothelial cellular injury.	Curcumin	26-34	nitric oxide synthase 2	Rattus norvegicus	63-67
18292803-6	2008	Further investigation demonstrated that curcumin abrogated histone acetylation, GATA4 acetylation, and DNA-binding activity through blocking p300-HAT activity.	Curcumin	40-48	GATA binding protein 4	Mus musculus	80-85
18292803-8	2008	Our results indicate that curcumin has the potential to protect against cardiac hypertrophy, inflammation, and fibrosis through suppression of p300-HAT activity and downstream GATA4, NF-kappaB, and TGF-beta-Smad signaling pathways.	Curcumin	26-34	GATA binding protein 4	Mus musculus	176-181
18292803-8	2008	Our results indicate that curcumin has the potential to protect against cardiac hypertrophy, inflammation, and fibrosis through suppression of p300-HAT activity and downstream GATA4, NF-kappaB, and TGF-beta-Smad signaling pathways.	Curcumin	26-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	183-192
18292809-4	2008	We found that curcumin inhibited the hypertrophy-induced acetylation and DNA-binding abilities of GATA4, a hypertrophy-responsive transcription factor, in rat cardiomyocytes.	Curcumin	14-22	GATA binding protein 4	Rattus norvegicus	98-103
18292809-5	2008	Curcumin also disrupted the p300/GATA4 complex and repressed agonist- and p300-induced hypertrophic responses in these cells.	Curcumin	0-8	GATA binding protein 4	Rattus norvegicus	33-38
18321195-13	2008	CONCLUSION: We found that curcumin decreased the expression of iNOS, p65, and serum nitric oxide levels, and helped prevent interstitial, glomerular, tubular epithelial, and endothelial cellular injury.	Curcumin	26-34	synaptotagmin 1	Rattus norvegicus	69-72
18234497-4	2008	In the present study, a series of curcumin analogues with more stable chemical structures were synthesized and several compounds showed an enhanced ability to inhibit lipopolysaccharide (LPS)-induced TNF-alpha and IL-6 synthesis in macrophages.	Curcumin	34-42	tumor necrosis factor	Homo sapiens	200-209
17953519-0	2008	Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity.	Curcumin	0-8	cell-division initiation protein	Bacillus subtilis subsp. subtilis str. 168	18-22
17953519-6	2008	Since the assembly dynamics of FtsZ protofilaments plays a major role in the formation and functioning of the Z-ring, we analysed the effects of curcumin on the assembly of FtsZ protofilaments.	Curcumin	145-153	cell-division initiation protein	Bacillus subtilis subsp. subtilis str. 168	173-177
18347134-10	2008	Upregulation of miRNA-22 expression by curcumin or by transfection with miRNA-22 mimetics in the PxBC-3 pancreatic cancer cell line suppressed expression of its target genes SP1 transcription factor (SP1) and estrogen receptor 1 (ESR1), while inhibiting miRNA-22 with antisense enhanced SP1 and ESR1 expression.	Curcumin	39-47	Sp1 transcription factor	Homo sapiens	174-198
18234497-4	2008	In the present study, a series of curcumin analogues with more stable chemical structures were synthesized and several compounds showed an enhanced ability to inhibit lipopolysaccharide (LPS)-induced TNF-alpha and IL-6 synthesis in macrophages.	Curcumin	34-42	interleukin 6	Homo sapiens	214-218
18001810-7	2008	Curcumin also inhibited the release of macrophage inflammatory protein-2 (MIP-2) from RLE cells as observed upon treatment with interleukin-1 beta (IL-1beta) and tumour necrosis factor-alpha (TNFalpha).	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	128-146
18001810-7	2008	Curcumin also inhibited the release of macrophage inflammatory protein-2 (MIP-2) from RLE cells as observed upon treatment with interleukin-1 beta (IL-1beta) and tumour necrosis factor-alpha (TNFalpha).	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	148-156
18001810-7	2008	Curcumin also inhibited the release of macrophage inflammatory protein-2 (MIP-2) from RLE cells as observed upon treatment with interleukin-1 beta (IL-1beta) and tumour necrosis factor-alpha (TNFalpha).	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	192-200
17965732-11	2008	In contrast, the stimulation of ERK signalling by constitutively active ERK prevented the inhibitory effects of curcumin.	Curcumin	112-120	mitogen-activated protein kinase 1	Homo sapiens	32-35
18187158-7	2008	Moreover, ODC overexpression prevented cytochrome c release and the activation of caspase-9 and caspase-3 following curcumin treatment.	Curcumin	116-124	caspase 3	Homo sapiens	96-105
18037556-0	2008	Investigating the binding of curcumin derivatives to bovine serum albumin.	Curcumin	29-37	albumin	Homo sapiens	60-73
17965732-0	2008	Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	137-140
17965732-10	2008	On the other hand, interruption of ERK signalling by inhibitors or dominant negative ERK, like curcumin, reduced NF-kappaB activity and in ctgf expression.	Curcumin	95-103	mitogen-activated protein kinase 1	Homo sapiens	35-38
17953519-7	2008	Curcumin inhibited the assembly of FtsZ protofilaments and also increased the GTPase activity of FtsZ.	Curcumin	0-8	cell-division initiation protein	Bacillus subtilis subsp. subtilis str. 168	35-39
17953519-7	2008	Curcumin inhibited the assembly of FtsZ protofilaments and also increased the GTPase activity of FtsZ.	Curcumin	0-8	cell-division initiation protein	Bacillus subtilis subsp. subtilis str. 168	97-101
17953519-8	2008	Electron microscopic analysis showed that curcumin reduced the bundling of FtsZ protofilaments in vitro.	Curcumin	42-50	cell-division initiation protein	Bacillus subtilis subsp. subtilis str. 168	75-79
17953519-9	2008	Further, curcumin was found to bind to FtsZ in vitro with a dissociation constant of 7.3+/-1.8 microM and the agent also perturbed the secondary structure of FtsZ.	Curcumin	9-17	cell-division initiation protein	Bacillus subtilis subsp. subtilis str. 168	39-43
17953519-9	2008	Further, curcumin was found to bind to FtsZ in vitro with a dissociation constant of 7.3+/-1.8 microM and the agent also perturbed the secondary structure of FtsZ.	Curcumin	9-17	cell-division initiation protein	Bacillus subtilis subsp. subtilis str. 168	158-162
17953519-10	2008	The results indicate that the perturbation of the GTPase activity of FtsZ assembly is lethal to bacteria and suggest that curcumin inhibits bacterial cell proliferation by inhibiting the assembly dynamics of FtsZ in the Z-ring.	Curcumin	122-130	cell-division initiation protein	Bacillus subtilis subsp. subtilis str. 168	69-73
17953519-10	2008	The results indicate that the perturbation of the GTPase activity of FtsZ assembly is lethal to bacteria and suggest that curcumin inhibits bacterial cell proliferation by inhibiting the assembly dynamics of FtsZ in the Z-ring.	Curcumin	122-130	cell-division initiation protein	Bacillus subtilis subsp. subtilis str. 168	208-212
18037917-8	2008	In this issue, Chen and co-workers propose that curcumin suppresses CTGF expression in HSC by inhibiting ERK and NF-kappaB activation.	Curcumin	48-56	mitogen-activated protein kinase 1	Homo sapiens	105-108
17965732-10	2008	On the other hand, interruption of ERK signalling by inhibitors or dominant negative ERK, like curcumin, reduced NF-kappaB activity and in ctgf expression.	Curcumin	95-103	mitogen-activated protein kinase 1	Homo sapiens	85-88
17965732-11	2008	In contrast, the stimulation of ERK signalling by constitutively active ERK prevented the inhibitory effects of curcumin.	Curcumin	112-120	mitogen-activated protein kinase 1	Homo sapiens	72-75
17965732-12	2008	CONCLUSIONS AND IMPLICATIONS: These results demonstrate that the interruption of NF-kappaB and ERK signalling by curcumin results in the suppression of ctgf expression in activated HSC in vitro.	Curcumin	113-121	mitogen-activated protein kinase 1	Homo sapiens	95-98
18049840-7	2008	All cells decreased NF-kappaB activity with curcumin(24 h) except PaCa-2, MEK activity with PD325901(24 h), and PI3Kinase with LY294002(3 h).	Curcumin	44-52	nuclear factor kappa B subunit 1	Homo sapiens	20-29
18235000-10	2008	The NF-kappaB inhibitor curcumin blocked the effects of TNF-alpha on TER and the subcellular localization of ZO-1 at late phase.	Curcumin	24-32	tumor necrosis factor	Homo sapiens	56-65
18049840-10	2008	For PANC-1, curcumin + gemcitabine was nearly synergistic, correlating with gemcitabine-induced NF-kappaB activity.	Curcumin	12-20	nuclear factor kappa B subunit 1	Homo sapiens	96-105
18006644-4	2008	This report demonstrates that curcumin significantly protects the liver from injury by reducing the activities of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, and by improving the histological architecture of the liver.	Curcumin	30-38	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	120-146
18006644-6	2008	Curcumin dramatically suppresses inflammation by reducing levels of inflammatory cytokines, including interferon-gamma, tumor necrosis factor-alpha, and interleukin-6.	Curcumin	0-8	interleukin 6	Rattus norvegicus	153-166
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	156-164
18390174-0	2008	[Curcumin inhibits the expression of vascular endothelial growth factor and androgen-independent prostate cancer cell line PC-3 in vitro].	Curcumin	1-9	vascular endothelial growth factor A	Homo sapiens	37-71
18390174-1	2008	OBJECTIVE: To study the effects of curcumin on the expression of the vascular endothelial growth factor (VEGF) and androgen-independent prostate cancer cell line PC-3, and to explore its anticarcinogenic mechanism.	Curcumin	35-43	vascular endothelial growth factor A	Homo sapiens	69-103
18390174-1	2008	OBJECTIVE: To study the effects of curcumin on the expression of the vascular endothelial growth factor (VEGF) and androgen-independent prostate cancer cell line PC-3, and to explore its anticarcinogenic mechanism.	Curcumin	35-43	vascular endothelial growth factor A	Homo sapiens	105-109
18390174-8	2008	Apoptosis-associated morphological changes were observed in PC-3 cells at 24 hours, and a marked decline in the expression of VEGF was noted after the exposure to different concentrations of curcumin within 24 hours.	Curcumin	191-199	vascular endothelial growth factor A	Homo sapiens	126-130
18390174-9	2008	CONCLUSION: Curcumin can suppress the growth of PC-3 cells, promote their apoptosis and arrest their cell cycle in the G2/M phase, and reduce the expression of VEGF mRNA and proteins, which may sever to explain its inhibitory effect on tumor and angiogenesis.	Curcumin	12-20	vascular endothelial growth factor A	Homo sapiens	160-164
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	B cell leukemia/lymphoma 2	Mus musculus	231-236
18093618-0	2008	Curcumin treatment enhances islet recovery by induction of heat shock response proteins, Hsp70 and heme oxygenase-1, during cryopreservation.	Curcumin	0-8	heat shock protein 1B	Mus musculus	89-94
18006147-0	2008	Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway.	Curcumin	0-8	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	49-54
18006147-0	2008	Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	83-86
18006147-0	2008	Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-97
18006147-4	2008	Transfection with a series of 5"-deleted constructs of the mdr1b gene promoter indicated that a proximal region between -205 and +42 of the sequence was responsible for the suppression of promoter activity by curcumin.	Curcumin	209-217	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	59-64
18006147-5	2008	This response might be associated with the inhibition of the phosphatidyinositol 3-kinase (PI3K)/Akt/nuclear factor-kappa B (NF-kappa B) signaling pathway by curcumin.	Curcumin	158-166	thymoma viral proto-oncogene 1	Mus musculus	97-100
18006147-5	2008	This response might be associated with the inhibition of the phosphatidyinositol 3-kinase (PI3K)/Akt/nuclear factor-kappa B (NF-kappa B) signaling pathway by curcumin.	Curcumin	158-166	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-135
18006147-7	2008	Thus, curcumin can contribute to the reversal of the MDR phenotype, probably due to the suppression of P-gp expression via the inhibition of the PI3K/Akt/NF-kappa B signaling pathway.	Curcumin	6-14	thymoma viral proto-oncogene 1	Mus musculus	150-153
18006147-7	2008	Thus, curcumin can contribute to the reversal of the MDR phenotype, probably due to the suppression of P-gp expression via the inhibition of the PI3K/Akt/NF-kappa B signaling pathway.	Curcumin	6-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	154-164
17918158-0	2008	Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	131-135
18093618-0	2008	Curcumin treatment enhances islet recovery by induction of heat shock response proteins, Hsp70 and heme oxygenase-1, during cryopreservation.	Curcumin	0-8	heme oxygenase 1	Mus musculus	99-115
18093618-9	2008	Elevated level of Hsp 70 and HO-1 were observed in islets cryopreserved with curcumin and may contribute to curcumin-induced islet rescue.	Curcumin	77-85	heat shock protein 1B	Mus musculus	18-24
18093618-9	2008	Elevated level of Hsp 70 and HO-1 were observed in islets cryopreserved with curcumin and may contribute to curcumin-induced islet rescue.	Curcumin	77-85	heme oxygenase 1	Mus musculus	29-33
18093618-9	2008	Elevated level of Hsp 70 and HO-1 were observed in islets cryopreserved with curcumin and may contribute to curcumin-induced islet rescue.	Curcumin	108-116	heat shock protein 1B	Mus musculus	18-24
18093618-9	2008	Elevated level of Hsp 70 and HO-1 were observed in islets cryopreserved with curcumin and may contribute to curcumin-induced islet rescue.	Curcumin	108-116	heme oxygenase 1	Mus musculus	29-33
18383847-6	2008	To investigate the effect of curcumin on NFkappaB activation, the protein levels of the NFkappaB subunit p65 of curcumin-treated cells were compared to untreated cells using Western blots.	Curcumin	112-120	nuclear factor kappa B subunit 1	Homo sapiens	88-96
17913594-6	2008	Examples include: activation of the Nrf-2 -- ARE pathway by sulforaphane and curcumin; activation of TRP ion channels by allicin and capsaicin; and activation of sirtuin-1 by resveratrol.	Curcumin	77-85	NFE2 like bZIP transcription factor 2	Homo sapiens	36-41
19000058-7	2008	Curcumin significantly decreased tissue malondialdehyde levels and significantly increased glutathione peroxidase, catalase and superoxide dismutase activities in the hippocampal tissue of portal hypertensive rats.	Curcumin	0-8	catalase	Rattus norvegicus	115-123
17943713-1	2008	Curcumin binds to the amyloid beta peptide (Abeta) and inhibits or modulates amyloid precursor protein (APP) metabolism.	Curcumin	0-8	amyloid beta precursor protein	Homo sapiens	44-49
18383847-0	2008	Curcumin induces apoptosis in human neuroblastoma cells via inhibition of NFkappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	74-82
18209571-10	2008	LPS-induced IL-6 promoter activation was also prevented by pretreatment with epigallocatechin 3-gallate, curcumin, and resveratrol.	Curcumin	105-113	interleukin 6	Homo sapiens	12-16
18389075-8	2008	When muscles from septic rats were treated with curcumin in vitro, proteasome-, calpain-, and cathepsin L-dependent protein breakdown rates were reduced, and nuclear NF-kappaB/p65 expression and activity as well as levels of phosphorylated (activated) p38 were decreased.	Curcumin	48-56	synaptotagmin 1	Rattus norvegicus	176-179
17996675-1	2007	Curcumin (1, 7-bis (4-hydroxyl-3-methoxyphenyl)-1, 6 heptadiene-3, 5-dione) is a potent natural anti oxidant and anti-inflammatory agent, which mediates its effects mainly by inhibiting the activity of enzymes like cyclooxygenase, lipooxygenases and phospholipase A2.	Curcumin	0-8	phospholipase A2 group IB	Homo sapiens	250-266
19003584-6	2008	Expression and activity of iNOS, COX-2, and 5-LOX are downregulated, and p21 is upregulated in tumor xenograft fed curcumin combined with fish oil diet when compared to individual diets.	Curcumin	115-123	linoleate 9S-lipoxygenase1	Zea mays	46-49
19192720-2	2008	Our previous in vitro studies have shown that curcumin sensitizes both hormone-sensitive and hormone-resistant prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and that combined curcumin/TRAIL treatment induces apoptosis in cancer cells by inhibiting antiapoptotic p-Akt and nuclear factor-kappaB (NF-kappaB).	Curcumin	46-54	TNF superfamily member 10	Homo sapiens	136-191
19192720-2	2008	Our previous in vitro studies have shown that curcumin sensitizes both hormone-sensitive and hormone-resistant prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and that combined curcumin/TRAIL treatment induces apoptosis in cancer cells by inhibiting antiapoptotic p-Akt and nuclear factor-kappaB (NF-kappaB).	Curcumin	46-54	TNF superfamily member 10	Homo sapiens	193-198
19192720-2	2008	Our previous in vitro studies have shown that curcumin sensitizes both hormone-sensitive and hormone-resistant prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and that combined curcumin/TRAIL treatment induces apoptosis in cancer cells by inhibiting antiapoptotic p-Akt and nuclear factor-kappaB (NF-kappaB).	Curcumin	46-54	TNF superfamily member 10	Homo sapiens	227-232
19192720-2	2008	Our previous in vitro studies have shown that curcumin sensitizes both hormone-sensitive and hormone-resistant prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and that combined curcumin/TRAIL treatment induces apoptosis in cancer cells by inhibiting antiapoptotic p-Akt and nuclear factor-kappaB (NF-kappaB).	Curcumin	218-226	TNF superfamily member 10	Homo sapiens	227-232
19192720-3	2008	In the present study, we demonstrate that curcumin and TRAIL combination regimen is also the most effective treatment for inhibiting the growth of PC3 xenografts compared to curcumin or TRAIL monotherpy.	Curcumin	174-182	TNF superfamily member 10	Homo sapiens	55-60
18849645-9	2008	RESULTS: Curcumin dose-dependently inhibited TNF-alpha and IL-1beta gene expression and protein synthesis in RAW264.7 cells stimulated with P. gingivalis LPS.	Curcumin	9-17	tumor necrosis factor	Mus musculus	45-54
18849645-9	2008	RESULTS: Curcumin dose-dependently inhibited TNF-alpha and IL-1beta gene expression and protein synthesis in RAW264.7 cells stimulated with P. gingivalis LPS.	Curcumin	9-17	interleukin 1 beta	Mus musculus	59-67
18289124-4	2008	We discovered that the addition of curcumin, a natural COX-2 inhibitor, to celecoxib synergistically (up to 1000%) augments the growth inhibitory effects of celecoxib in in-vitro and in-vivo models of arthritis and cancer, thus rendering effective action of the drug at up to tenfold lower dose.	Curcumin	35-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	55-60
17949793-12	2008	Furthermore, antioxidant curcumin dramatically inhibited CRP-induced PAI-1 mRNA expression.	Curcumin	25-33	C-reactive protein	Homo sapiens	57-60
20020854-6	2008	Cells were pretreated with the AP-1 inhibitor curcumin (10, 25, 50 muM), and silica-induced PAI-1 expression was reduced by 20%, 63%, and 65%, respectively.	Curcumin	46-54	latexin	Homo sapiens	67-70
17959149-2	2007	We have examined the oxidative folding of the model four-disulfide-bond-containing protein bovine pancreatic ribonuclease A (RNase A) in its presence; results indicate that RNase A regeneration rate increases in a curcumin-dependent manner.	Curcumin	214-222	ribonuclease pancreatic	Bos taurus	125-132
17959149-2	2007	We have examined the oxidative folding of the model four-disulfide-bond-containing protein bovine pancreatic ribonuclease A (RNase A) in its presence; results indicate that RNase A regeneration rate increases in a curcumin-dependent manner.	Curcumin	214-222	ribonuclease pancreatic	Bos taurus	173-180
17996675-7	2007	EMSA and super shift showed activation of classical NFkappaB in in vitro activated PBMCs and treatment with curcumin inhibited activation of NFkappaB.	Curcumin	108-116	nuclear factor kappa B subunit 1	Homo sapiens	141-149
17996675-9	2007	Curcumin inhibited the degradation of IkappaB-alpha, which inhibited the ALA mediated activation of NFkappaB and upregulation of MMP-9.	Curcumin	0-8	NFKB inhibitor alpha	Homo sapiens	38-51
17996675-9	2007	Curcumin inhibited the degradation of IkappaB-alpha, which inhibited the ALA mediated activation of NFkappaB and upregulation of MMP-9.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	100-108
17973899-0	2007	The role of haem oxygenase-1 in the decrease of endothelial intercellular adhesion molecule-1 expression by curcumin.	Curcumin	108-116	heme oxygenase 1	Mus musculus	12-28
18001039-10	2007	The serum TNF-alpha level was markedly reduced in curcumin-treated rats.	Curcumin	50-58	tumor necrosis factor	Rattus norvegicus	10-19
17927689-0	2007	Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells.	Curcumin	0-8	CREB binding protein	Homo sapiens	44-47
17927689-0	2007	Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	94-116
18302884-7	2008	In 20 micromol/L Curcumin prevention group and silica stimulated group, the expression of TNF-alpha protein were 23.58 +/- 45.78 and 32.12 +/- 5.34, and the expression of TGF-beta(1) protein were 1582.18 +/- 437.52 and 55.60 +/- 5.51 (P &lt; 0.05 =; the expression of TNF-alpha, TGF-beta(1) mRNA were 0.74 +/- 0.01, 0.22 +/- 0.04 and 2.27 +/- 0.33, 2.96 +/- 0.15 (P &lt; 0.05 =.	Curcumin	17-25	tumor necrosis factor	Mus musculus	90-99
18302884-7	2008	In 20 micromol/L Curcumin prevention group and silica stimulated group, the expression of TNF-alpha protein were 23.58 +/- 45.78 and 32.12 +/- 5.34, and the expression of TGF-beta(1) protein were 1582.18 +/- 437.52 and 55.60 +/- 5.51 (P &lt; 0.05 =; the expression of TNF-alpha, TGF-beta(1) mRNA were 0.74 +/- 0.01, 0.22 +/- 0.04 and 2.27 +/- 0.33, 2.96 +/- 0.15 (P &lt; 0.05 =.	Curcumin	17-25	tumor necrosis factor	Mus musculus	268-277
17927689-9	2007	The results suggest that the depressive effect of curcumin on NF-kappaB signal transduction pathway may be mediated via the various components of the HDACs and p300/Notch 1 signal molecules, and may represent a new remedy for acute leukaemia.	Curcumin	50-58	notch receptor 1	Homo sapiens	165-172
17927689-0	2007	Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells.	Curcumin	0-8	notch receptor 1	Homo sapiens	121-128
17973899-3	2007	We investigated the role of HO-1 in the action of curcumin, a naturally occurring yellow pigment isolated from plant Curcuma longa L., on ICAM-1 expression in tumour necrosis factor-alpha-stimulated EA.hy926 cells and lungs of lipopolysaccharide-treated mice.	Curcumin	50-58	heme oxygenase 1	Mus musculus	28-32
17927689-3	2007	Here, we investigate the effect of curcumin on the activation of NF-kappaB signal molecule in Raji cells to explore its relationship with HDACs or p300/CREB binding protein (CBP).	Curcumin	35-43	nuclear factor kappa B subunit 1	Homo sapiens	65-74
17927689-3	2007	Here, we investigate the effect of curcumin on the activation of NF-kappaB signal molecule in Raji cells to explore its relationship with HDACs or p300/CREB binding protein (CBP).	Curcumin	35-43	CREB binding protein	Homo sapiens	152-172
17973899-4	2007	Both, in vitro and in vivo curcumin induced HO-1 and curcumin-elicited induction of HO-1 was associated with inhibition ICAM-1 expression.	Curcumin	27-35	heme oxygenase 1	Mus musculus	44-48
17927689-3	2007	Here, we investigate the effect of curcumin on the activation of NF-kappaB signal molecule in Raji cells to explore its relationship with HDACs or p300/CREB binding protein (CBP).	Curcumin	35-43	CREB binding protein	Homo sapiens	174-177
17927689-5	2007	Significant decreases in the amounts of p300, HDAC1 and HDAC3 were detected after treatment with curcumin.	Curcumin	97-105	histone deacetylase 1	Homo sapiens	46-51
17973899-4	2007	Both, in vitro and in vivo curcumin induced HO-1 and curcumin-elicited induction of HO-1 was associated with inhibition ICAM-1 expression.	Curcumin	53-61	heme oxygenase 1	Mus musculus	84-88
17927689-7	2007	The protection degradation of HDAC1 and p300 by MG-132 could be partially reversed by curcumin.	Curcumin	86-94	histone deacetylase 1	Homo sapiens	30-35
17973899-7	2007	We conclude that induction of HO-1, via decrease of endothelial ICAM-1, plays a pivotal role in curcumin-dependent prevention of pulmonary sequestration of neutrophils in a mouse model of endotoxaemia.	Curcumin	96-104	heme oxygenase 1	Mus musculus	30-34
17927689-8	2007	Furthermore, curcumin could also prevent degradation of I kappaB alpha and inhibit nuclear translocation of the NF-kappaB/p65 subunit, as well as expression of Notch 1, induced by tumour necrosis factor-alpha.	Curcumin	13-21	NFKB inhibitor alpha	Homo sapiens	56-70
17927689-8	2007	Furthermore, curcumin could also prevent degradation of I kappaB alpha and inhibit nuclear translocation of the NF-kappaB/p65 subunit, as well as expression of Notch 1, induced by tumour necrosis factor-alpha.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	112-121
18156803-0	2007	Linkage of curcumin-induced cell cycle arrest and apoptosis by cyclin-dependent kinase inhibitor p21(/WAF1/CIP1).	Curcumin	11-19	cyclin dependent kinase inhibitor 1A	Homo sapiens	97-100
17927689-8	2007	Furthermore, curcumin could also prevent degradation of I kappaB alpha and inhibit nuclear translocation of the NF-kappaB/p65 subunit, as well as expression of Notch 1, induced by tumour necrosis factor-alpha.	Curcumin	13-21	notch receptor 1	Homo sapiens	160-167
17927689-9	2007	The results suggest that the depressive effect of curcumin on NF-kappaB signal transduction pathway may be mediated via the various components of the HDACs and p300/Notch 1 signal molecules, and may represent a new remedy for acute leukaemia.	Curcumin	50-58	nuclear factor kappa B subunit 1	Homo sapiens	62-71
17764466-8	2007	The use of nuclear factor-kappa B (NFkappaB) inhibitors, diferuloylmethane (curcumin) and SN50, abrogated bacterial infiltration of both untreated and interferon-gamma-treated cells.	Curcumin	57-74	interferon gamma	Homo sapiens	151-167
17764466-8	2007	The use of nuclear factor-kappa B (NFkappaB) inhibitors, diferuloylmethane (curcumin) and SN50, abrogated bacterial infiltration of both untreated and interferon-gamma-treated cells.	Curcumin	76-84	interferon gamma	Homo sapiens	151-167
18156803-0	2007	Linkage of curcumin-induced cell cycle arrest and apoptosis by cyclin-dependent kinase inhibitor p21(/WAF1/CIP1).	Curcumin	11-19	cyclin dependent kinase inhibitor 1A	Homo sapiens	102-106
18156803-0	2007	Linkage of curcumin-induced cell cycle arrest and apoptosis by cyclin-dependent kinase inhibitor p21(/WAF1/CIP1).	Curcumin	11-19	cyclin dependent kinase inhibitor 1A	Homo sapiens	107-111
18156803-1	2007	We have recently shown that curcumin induces apoptosis in prostate cancer cells through Bax translocation to mitochondria and caspase activation, and enhances the therapeutic potential of TRAIL.	Curcumin	28-36	BCL2 associated X, apoptosis regulator	Homo sapiens	88-91
18156803-1	2007	We have recently shown that curcumin induces apoptosis in prostate cancer cells through Bax translocation to mitochondria and caspase activation, and enhances the therapeutic potential of TRAIL.	Curcumin	28-36	TNF superfamily member 10	Homo sapiens	188-193
18156803-5	2007	Curcumin induced the expression of cyclin-dependent kinase (CDK) inhibitors p16(/INK4a), p21(/WAF1/CIP1) and p27(/KIP1), and inhibited the expression of cyclin E and cyclin D1, and hyperphosphorylation of retinoblastoma (Rb) protein.	Curcumin	0-8	cyclin dependent kinase inhibitor 2A	Homo sapiens	76-79
18156803-5	2007	Curcumin induced the expression of cyclin-dependent kinase (CDK) inhibitors p16(/INK4a), p21(/WAF1/CIP1) and p27(/KIP1), and inhibited the expression of cyclin E and cyclin D1, and hyperphosphorylation of retinoblastoma (Rb) protein.	Curcumin	0-8	cyclin dependent kinase inhibitor 2A	Homo sapiens	81-86
17975885-10	2007	Given that GSTM1a-1a and GSTP1-1 are present in the intestinal epithelial cells, it can be concluded that efficient glutathione conjugation of curcumin may already occur in the enterocytes, followed by an efficient excretion of these glutathione conjugates to the lumen, thereby reducing the bioavailability of (unconjugated) curcumin.	Curcumin	143-151	glutathione S-transferase mu 1	Homo sapiens	11-20
17975885-11	2007	In conclusion, the present study identifies the nature of the diastereoisomeric monoglutathionyl curcumin conjugates, CURSG-1 and CURSG-2 formed in biological systems, and reveals that conjugate formation is catalyzed by GSTM1a-1a, GSTA1-1, and/or GSTP1-1 with different stereoselective preference.	Curcumin	97-105	glutathione S-transferase mu 1	Homo sapiens	221-230
18156803-5	2007	Curcumin induced the expression of cyclin-dependent kinase (CDK) inhibitors p16(/INK4a), p21(/WAF1/CIP1) and p27(/KIP1), and inhibited the expression of cyclin E and cyclin D1, and hyperphosphorylation of retinoblastoma (Rb) protein.	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	89-92
18156803-5	2007	Curcumin induced the expression of cyclin-dependent kinase (CDK) inhibitors p16(/INK4a), p21(/WAF1/CIP1) and p27(/KIP1), and inhibited the expression of cyclin E and cyclin D1, and hyperphosphorylation of retinoblastoma (Rb) protein.	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	94-98
18156803-5	2007	Curcumin induced the expression of cyclin-dependent kinase (CDK) inhibitors p16(/INK4a), p21(/WAF1/CIP1) and p27(/KIP1), and inhibited the expression of cyclin E and cyclin D1, and hyperphosphorylation of retinoblastoma (Rb) protein.	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	99-103
18156803-8	2007	The inhibition of p21(/WAF1/CIP1) by siRNA blocks curcumin-induced apoptosis, thus establishing a link between cell cycle and apoptosis.	Curcumin	50-58	cyclin dependent kinase inhibitor 1A	Homo sapiens	18-21
18156803-8	2007	The inhibition of p21(/WAF1/CIP1) by siRNA blocks curcumin-induced apoptosis, thus establishing a link between cell cycle and apoptosis.	Curcumin	50-58	cyclin dependent kinase inhibitor 1A	Homo sapiens	23-27
18156803-8	2007	The inhibition of p21(/WAF1/CIP1) by siRNA blocks curcumin-induced apoptosis, thus establishing a link between cell cycle and apoptosis.	Curcumin	50-58	cyclin dependent kinase inhibitor 1A	Homo sapiens	28-32
17471506-7	2007	The modulation of irradiation-induced activation of PKCdelta and NFkappaB by curcumin and the complex was found different at later time periods although the initial response was similar.	Curcumin	77-85	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	65-73
18375636-5	2007	Curcumin (200 mg/kg) pretreatment for 20 days in isoproterenol treated rats significantly lowered (P &lt; 0.01) the serum lactate dehydrogenase, creatine kinase, aspartate transaminase, alanine transaminase, and myocardial lipid peroxides levels and increased the levels of myocardial endogenous antioxidants (superoxide dismutase, catalase, and tissue glutathione) as compared to pathogenic control rats.	Curcumin	0-8	catalase	Rattus norvegicus	332-340
17880909-0	2007	Curcumin suppresses the transformation of an aryl hydrocarbon receptor through its phosphorylation.	Curcumin	0-8	aryl-hydrocarbon receptor	Mus musculus	45-70
17786026-0	2007	Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy.	Curcumin	62-70	AKT serine/threonine kinase 1	Homo sapiens	13-16
17786026-0	2007	Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy.	Curcumin	62-70	mechanistic target of rapamycin kinase	Homo sapiens	17-21
17786026-0	2007	Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy.	Curcumin	62-70	mitogen-activated protein kinase 3	Homo sapiens	33-39
17493651-6	2007	In contrast, apigenin, a dietary flavonoid derived from plants and vegetables, and curcumin, an agent derived from turmeric, inhibit differentiation by suppressing MAPK signal transduction and reducing API transcription factor level.	Curcumin	83-91	mitogen-activated protein kinase 3	Homo sapiens	164-168
17594054-0	2007	Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma.	Curcumin	0-8	tumor protein p53	Homo sapiens	45-48
17594054-12	2007	The results demonstrate that curcumin exerts inhibitory action on glioma cell growth and proliferation via induction of cell cycle arrest instead of induction of apoptosis in a p53-dependent manner, and ING4 possibly is in part involved in the signal pathways.	Curcumin	29-37	tumor protein p53	Homo sapiens	177-180
18082042-10	2007	Curcumin pretreatment decreased significantly ROS and JNK/SAPK levels as well as the apoptosis rate when compared with the CuSO4-treated alone group (P &lt; 0.01).	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	54-62
18082042-13	2007	Curcumin produced protections on copper-injured BRL cells possibly by anti-oxidation and inhibition of p-JNK expression.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	105-108
18025290-4	2007	Curcumin, EGCG, and I3C inhibited clonogenic growth by 55% to 60% and induced 1.5- to 2-fold higher levels of the basal caspase-3/7 activity.	Curcumin	0-8	caspase 3	Homo sapiens	120-129
18025290-8	2007	DIM and curcumin decreased cadherin-11 and increased urokinase-type plasminogen activator levels correlated with increased cell motility.	Curcumin	8-16	cadherin 11	Homo sapiens	27-38
18025290-8	2007	DIM and curcumin decreased cadherin-11 and increased urokinase-type plasminogen activator levels correlated with increased cell motility.	Curcumin	8-16	plasminogen activator, urokinase	Homo sapiens	53-89
17880909-3	2007	In the nucleus, curcumin inhibited the TCDD-induced heterodimerization of the AhR with an AhR nuclear translocator (Arnt), an essential partner for the transformation, and also dose-dependently inhibited the TCDD-evoked phosphorylation of both the AhR and Arnt.	Curcumin	16-24	aryl-hydrocarbon receptor	Mus musculus	78-81
17880909-3	2007	In the nucleus, curcumin inhibited the TCDD-induced heterodimerization of the AhR with an AhR nuclear translocator (Arnt), an essential partner for the transformation, and also dose-dependently inhibited the TCDD-evoked phosphorylation of both the AhR and Arnt.	Curcumin	16-24	aryl-hydrocarbon receptor	Mus musculus	90-93
18323214-10	2007	Curcumin could decrease cytokine levels of NO, TGF-beta1, TNF-alpha, P &lt; 0.05.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	47-56
17880909-5	2007	In a cell-free system, curcumin inhibited the binding of 3-methylcholanthrene, an AhR agonist, to the receptor.	Curcumin	23-31	aryl-hydrocarbon receptor	Mus musculus	82-85
17880909-6	2007	These results indicate that curcumin is able to bind to the AhR as a ligand, but suppresses its transformation by inhibiting the phosphorylation of AhR and Arnt, probably by PKC.	Curcumin	28-36	aryl-hydrocarbon receptor	Mus musculus	60-63
18323214-10	2007	Curcumin could decrease cytokine levels of NO, TGF-beta1, TNF-alpha, P &lt; 0.05.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	58-67
17880909-6	2007	These results indicate that curcumin is able to bind to the AhR as a ligand, but suppresses its transformation by inhibiting the phosphorylation of AhR and Arnt, probably by PKC.	Curcumin	28-36	aryl-hydrocarbon receptor	Mus musculus	148-151
17916240-0	2007	Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	54-59
17916240-1	2007	BACKGROUND: We have recently shown that curcumin (a diferuloylmethane) inhibits growth and induces apoptosis, and also demonstrated that TRAIL induces apoptosis by binding to specific cell surface death receptors in prostate cancer cells.	Curcumin	40-48	TNF superfamily member 10	Homo sapiens	137-142
17883952-6	2007	Curcumin also attenuated the expressions of inducible NO synthase and cyclooxygenase-2 mRNA and protein levels.	Curcumin	0-8	nitric oxide synthase 2	Homo sapiens	44-65
17883952-6	2007	Curcumin also attenuated the expressions of inducible NO synthase and cyclooxygenase-2 mRNA and protein levels.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	70-86
17916240-2	2007	The objectives of this paper were to investigate the molecular mechanisms by which curcumin enhanced the apoptosis-inducing potential of TRAIL in prostate cancer cells.	Curcumin	83-91	TNF superfamily member 10	Homo sapiens	137-142
17916240-3	2007	RESULTS: Curcumin enhanced the apoptosis-inducing potential of TRAIL in androgen-unresponsive PC-3 cells and sensitized androgen-responsive TRAIL-resistant LNCaP cells.	Curcumin	9-17	TNF superfamily member 10	Homo sapiens	63-68
17916240-3	2007	RESULTS: Curcumin enhanced the apoptosis-inducing potential of TRAIL in androgen-unresponsive PC-3 cells and sensitized androgen-responsive TRAIL-resistant LNCaP cells.	Curcumin	9-17	TNF superfamily member 10	Homo sapiens	140-145
17916240-4	2007	Curcumin inhibited the expressions of Bcl-2, Bcl-XL, survivin and XIAP, and induced the expressions Bax, Bak, PUMA, Bim, and Noxa and death receptors (TRAIL-R1/DR4 and TRAIL-R2/DR5) in both cell lines.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	151-156
17916240-4	2007	Curcumin inhibited the expressions of Bcl-2, Bcl-XL, survivin and XIAP, and induced the expressions Bax, Bak, PUMA, Bim, and Noxa and death receptors (TRAIL-R1/DR4 and TRAIL-R2/DR5) in both cell lines.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	168-173
17916240-6	2007	Treatment of these cells with curcumin resulted in activation of caspase-3, and caspase-9, and drop in mitochondrial membrane potential, and these events were further enhanced when combined with TRAIL.	Curcumin	30-38	caspase 3	Homo sapiens	65-74
17916240-6	2007	Treatment of these cells with curcumin resulted in activation of caspase-3, and caspase-9, and drop in mitochondrial membrane potential, and these events were further enhanced when combined with TRAIL.	Curcumin	30-38	TNF superfamily member 10	Homo sapiens	195-200
17916240-8	2007	CONCLUSION: The ability of curcumin to inhibit capillary tube formation and cell migration, and enhance the therapeutic potential of TRAIL suggests that curcumin alone or in combination with TRAIL can be used for prostate cancer prevention and/or therapy.	Curcumin	153-161	TNF superfamily member 10	Homo sapiens	133-138
17697941-5	2007	The results demonstrated that HepG2 cells challenged with curcumin for 1 h showed a transient elevation of the mitochondrial membrane potential (DeltaPsim), followed by cytochrome c release into the cytosol and disruption of DeltaPsim after 6 h exposure to curcumin.	Curcumin	58-66	cytochrome c, somatic	Homo sapiens	169-181
18007069-3	2007	Curcumin was added into the culture medium to inhibit the AP-1 activity before incubating with TGF-beta1.	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-62
18007069-7	2007	Curcumin ( 5, 10, 15, and 20 micromol/L) could inhibit the AP-1 DNA binding activity in TGF-beta1-stimulated cells (the inhibition ratio was 17.1%, 17.6%, 24.2%, and 31.3%; P&lt;0.05).	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	59-63
18007069-7	2007	Curcumin ( 5, 10, 15, and 20 micromol/L) could inhibit the AP-1 DNA binding activity in TGF-beta1-stimulated cells (the inhibition ratio was 17.1%, 17.6%, 24.2%, and 31.3%; P&lt;0.05).	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	88-97
17885582-0	2007	Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	52-61
17885582-7	2007	Curcumin has been shown to inhibit NF-kappaB activity in several cell types.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	35-44
17885582-10	2007	A curcumin dose-dependent inhibition of NF-kappaB-driven reporter activity correlated with decreased levels of phospho-IkappaBalpha, and decreased expression of NF-kappaB-target genes COX-2 and cyclin D1.	Curcumin	2-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	40-49
17885582-10	2007	A curcumin dose-dependent inhibition of NF-kappaB-driven reporter activity correlated with decreased levels of phospho-IkappaBalpha, and decreased expression of NF-kappaB-target genes COX-2 and cyclin D1.	Curcumin	2-10	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	119-131
17885582-10	2007	A curcumin dose-dependent inhibition of NF-kappaB-driven reporter activity correlated with decreased levels of phospho-IkappaBalpha, and decreased expression of NF-kappaB-target genes COX-2 and cyclin D1.	Curcumin	2-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	161-170
17885582-12	2007	We furthermore conclude that curcumin, a natural and safe compound, inhibits NF-kappaB activity and the expression of its downstream target genes, and also selectively induces apoptosis of melanoma cells but not normal melanocytes.	Curcumin	29-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	77-86
18161303-0	2007	[Inhibition of curcumin on histone deacetylase and expression promotion of P21 (WAF1/CIP1) in HepG2 cells].	Curcumin	15-23	cyclin dependent kinase inhibitor 1A	Homo sapiens	75-78
18161303-0	2007	[Inhibition of curcumin on histone deacetylase and expression promotion of P21 (WAF1/CIP1) in HepG2 cells].	Curcumin	15-23	cyclin dependent kinase inhibitor 1A	Homo sapiens	80-89
18161303-1	2007	OBJECTIVE: To investigate the effect of curcumin (Cur) on histone deacetylase (HDAC1) and P21(WAF1/CIP1), a cyclin dependent kinase inhibitor, in HepG2 cells for exploring the mechanism of Cur in anti-cancer.	Curcumin	40-48	histone deacetylase 1	Homo sapiens	79-84
18161303-1	2007	OBJECTIVE: To investigate the effect of curcumin (Cur) on histone deacetylase (HDAC1) and P21(WAF1/CIP1), a cyclin dependent kinase inhibitor, in HepG2 cells for exploring the mechanism of Cur in anti-cancer.	Curcumin	40-48	cyclin dependent kinase inhibitor 1A	Homo sapiens	90-103
17697941-5	2007	The results demonstrated that HepG2 cells challenged with curcumin for 1 h showed a transient elevation of the mitochondrial membrane potential (DeltaPsim), followed by cytochrome c release into the cytosol and disruption of DeltaPsim after 6 h exposure to curcumin.	Curcumin	257-265	cytochrome c, somatic	Homo sapiens	169-181
17827730-10	2007	Moreover, Cp-Mn and DiAc-Cp-Mn administration suppressed the KA-induced expression of c-jun, COX-2, BDNF, and iNOS mRNA, whereas curcumin attenuated only iNOS mRNA expression.	Curcumin	129-137	nitric oxide synthase 2	Rattus norvegicus	154-158
17535857-6	2007	Demethoxy curcuminoids induced HO-1 promoter linked to the luciferase reporter gene more effectively than curcumin.	Curcumin	10-18	heme oxygenase 1	Mus musculus	31-35
17590421-0	2007	Curcumin down-regulates Ets-1 and Bcl-2 expression in human endometrial carcinoma HEC-1-A cells.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	34-39
17540543-9	2007	All obtained data showed that incorporating curcumin in rapamycin-loaded PLGA coating can significantly decrease platelet adhesion and activation, prolong APTT clotting time as well as decrease the fibrinogen adsorption.	Curcumin	44-52	fibrinogen beta chain	Homo sapiens	198-208
17882652-3	2007	In this study, we investigated whether the phytochemical curcumin, a natural COX-2 inhibitor, can potentiate gemcitabine effect on survival of human pancreatic cancer cells.	Curcumin	57-65	prostaglandin-endoperoxide synthase 2	Homo sapiens	77-82
17882652-8	2007	RESULTS: Curcumin increased the inhibitory effect of gemcitabine on cell viability as well as its pro-apoptotic effect in COX-2 positive, p34 cells, but not in COX-2 negative, Panc-1 cells.	Curcumin	9-17	prostaglandin-endoperoxide synthase 2	Homo sapiens	122-127
17882652-9	2007	In p34 cells, combination of curcumin and gemcitabine downregulated both COX-2 and p-ERK1/2 in a dose-dependent manner.	Curcumin	29-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	73-78
17882652-9	2007	In p34 cells, combination of curcumin and gemcitabine downregulated both COX-2 and p-ERK1/2 in a dose-dependent manner.	Curcumin	29-37	mitogen-activated protein kinase 3	Homo sapiens	85-91
17590421-0	2007	Curcumin down-regulates Ets-1 and Bcl-2 expression in human endometrial carcinoma HEC-1-A cells.	Curcumin	0-8	NDC80 kinetochore complex component	Homo sapiens	82-87
17590421-2	2007	The present study was undertaken to determine the effect of curcumin on the expression of the proto-oncogene Ets-1 and the anti-apoptotic molecule Bcl-2 in human endometrial adenocarcinoma HEC-1-A cells.	Curcumin	60-68	NDC80 kinetochore complex component	Homo sapiens	189-194
17590421-3	2007	METHODS: Confluent HEC-1-A cells were treated with curcumin at various doses for 16 h or at 60 microM for various time points.	Curcumin	51-59	NDC80 kinetochore complex component	Homo sapiens	19-24
17590421-6	2007	RESULTS: Curcumin induced apoptosis-like morphological changes and DNA degradation and decreased basal levels of Ets-1 and Bcl-2 protein contents in HEC-1-A cells in a time- and dose-dependent manner.	Curcumin	9-17	BCL2 apoptosis regulator	Homo sapiens	123-128
17590421-6	2007	RESULTS: Curcumin induced apoptosis-like morphological changes and DNA degradation and decreased basal levels of Ets-1 and Bcl-2 protein contents in HEC-1-A cells in a time- and dose-dependent manner.	Curcumin	9-17	NDC80 kinetochore complex component	Homo sapiens	149-154
17590421-8	2007	CONCLUSIONS: Curcumin down-regulates Ets-1 and Bcl-2 expression and induces apoptosis in HEC-1-A cells, suggesting a novel molecular mechanism for the anti-tumor activity of curcumin.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	47-52
17590421-8	2007	CONCLUSIONS: Curcumin down-regulates Ets-1 and Bcl-2 expression and induces apoptosis in HEC-1-A cells, suggesting a novel molecular mechanism for the anti-tumor activity of curcumin.	Curcumin	13-21	NDC80 kinetochore complex component	Homo sapiens	89-94
17590421-8	2007	CONCLUSIONS: Curcumin down-regulates Ets-1 and Bcl-2 expression and induces apoptosis in HEC-1-A cells, suggesting a novel molecular mechanism for the anti-tumor activity of curcumin.	Curcumin	174-182	BCL2 apoptosis regulator	Homo sapiens	47-52
17590421-8	2007	CONCLUSIONS: Curcumin down-regulates Ets-1 and Bcl-2 expression and induces apoptosis in HEC-1-A cells, suggesting a novel molecular mechanism for the anti-tumor activity of curcumin.	Curcumin	174-182	NDC80 kinetochore complex component	Homo sapiens	89-94
17718901-1	2007	BACKGROUND: We have previously shown that prostate cancer LNCaP cells are resistant to TRAIL, and downregulation of PI-3K/Akt pathway by molecular and pharmacological means sensitizes cells to undergo apoptosis by TRAIL and curcumin.	Curcumin	224-232	AKT serine/threonine kinase 1	Homo sapiens	122-125
17671742-4	2007	RT-PCR and immunoblotting showed that treating the cells with curcumin resulted in the down-regulation of anti-apoptotic Bcl-2 and the X-linked inhibitor of the apoptosis protein as well as the up-regulation of pro-apoptotic Bax expression in a concentration-dependent manner.	Curcumin	62-70	BCL2 apoptosis regulator	Homo sapiens	121-126
17671742-4	2007	RT-PCR and immunoblotting showed that treating the cells with curcumin resulted in the down-regulation of anti-apoptotic Bcl-2 and the X-linked inhibitor of the apoptosis protein as well as the up-regulation of pro-apoptotic Bax expression in a concentration-dependent manner.	Curcumin	62-70	BCL2 associated X, apoptosis regulator	Homo sapiens	225-228
17671742-5	2007	Curcumin-induced apoptosis was also associated with the proteolytic activation of caspase-3 and caspase-9, and the concomitant degradation of poly(ADP-ribose) polymerase protein.	Curcumin	0-8	caspase 3	Homo sapiens	82-91
17671742-6	2007	Furthermore, curcumin decreased the expression levels of the cyclooxygenase (COX)-2 mRNA and protein without causing significant changes in the COX-1 levels, which was correlated with the inhibition of prostaglandin E(2) synthesis.	Curcumin	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-83
17429597-9	2007	Here we show that the proteasome-dependent degradation of COX-2 in HeLa cell lysate and in HeLa cells was stimulated by curcumin, an inhibitor of CSN-associated kinases.	Curcumin	120-128	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-63
17671737-5	2007	RT-PCR evaluations performed in MCF-7 and MCF-7R showed that curcumin or MR 39 produced early modifications in the amounts of relevant gene transcripts, which, however, were mostly diverse (i.e. represented by decreases in IAPs and COX-2 in MCF-7R versus reductions in Bcl-2 and Bcl-XL as well as increases in the Bcl-XS/Bcl-XL ratio in MCF-7) in the two cell lines.	Curcumin	61-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	232-237
17671737-5	2007	RT-PCR evaluations performed in MCF-7 and MCF-7R showed that curcumin or MR 39 produced early modifications in the amounts of relevant gene transcripts, which, however, were mostly diverse (i.e. represented by decreases in IAPs and COX-2 in MCF-7R versus reductions in Bcl-2 and Bcl-XL as well as increases in the Bcl-XS/Bcl-XL ratio in MCF-7) in the two cell lines.	Curcumin	61-69	BCL2 apoptosis regulator	Homo sapiens	269-274
17671737-5	2007	RT-PCR evaluations performed in MCF-7 and MCF-7R showed that curcumin or MR 39 produced early modifications in the amounts of relevant gene transcripts, which, however, were mostly diverse (i.e. represented by decreases in IAPs and COX-2 in MCF-7R versus reductions in Bcl-2 and Bcl-XL as well as increases in the Bcl-XS/Bcl-XL ratio in MCF-7) in the two cell lines.	Curcumin	61-69	BCL2 like 1	Homo sapiens	279-285
17671737-5	2007	RT-PCR evaluations performed in MCF-7 and MCF-7R showed that curcumin or MR 39 produced early modifications in the amounts of relevant gene transcripts, which, however, were mostly diverse (i.e. represented by decreases in IAPs and COX-2 in MCF-7R versus reductions in Bcl-2 and Bcl-XL as well as increases in the Bcl-XS/Bcl-XL ratio in MCF-7) in the two cell lines.	Curcumin	61-69	BCL2 like 1	Homo sapiens	321-327
17979888-6	2007	Our aim was to investigate the effects of curcumin on the ability of T cells to respond to IL-12 or IFN-alpha/beta.	Curcumin	42-50	interferon alpha 1	Homo sapiens	100-109
17979888-7	2007	We report that curcumin decreases IL-12-induced STAT4 phosphorylation, IFN-gamma production, and IL-12 Rbeta1 and beta2 expression.	Curcumin	15-23	interferon gamma	Homo sapiens	71-80
17979888-7	2007	We report that curcumin decreases IL-12-induced STAT4 phosphorylation, IFN-gamma production, and IL-12 Rbeta1 and beta2 expression.	Curcumin	15-23	interleukin 12 receptor subunit beta 1	Homo sapiens	97-109
17979888-9	2007	Curcumin increased IFN-alpha-induced IL-10 and IFNAR1 expression.	Curcumin	0-8	interferon alpha 1	Homo sapiens	19-28
17979888-10	2007	Prior exposure to curcumin decreased IFN-alpha-induced IFNAR2 expression and did not modify the level of IFN-alpha-induced pSTAT4 generation.	Curcumin	18-26	interferon alpha 1	Homo sapiens	37-46
17897073-0	2007	Curcumin contributes to in vitro removal of non-transferrin bound iron by deferiprone and desferrioxamine in thalassemic plasma.	Curcumin	0-8	transferrin	Homo sapiens	48-59
17640564-6	2007	Curcumin accelerated the nuclear translocation of nuclear factor-erythroid 2-related factor 2 (Nrf2), and overexpression of Nrf2, but not the dominant negative Nrf2, enhanced the promoter activity of the AR gene.	Curcumin	0-8	aldo-keto reductase family 1 member B	Homo sapiens	204-206
17640564-0	2007	Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage.	Curcumin	140-148	aldo-keto reductase family 1 member B	Homo sapiens	17-33
17640564-0	2007	Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage.	Curcumin	140-148	AKT serine/threonine kinase 1	Homo sapiens	87-90
17640564-0	2007	Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage.	Curcumin	140-148	NFE2 like bZIP transcription factor 2	Homo sapiens	95-99
17640564-9	2007	Taken together, the activation of PI3K and p38 MAPK by curcumin augmented the expression of the AR gene via Nrf2, and increased AR activity may be an important cellular response against oxidative stress.	Curcumin	55-63	aldo-keto reductase family 1 member B	Homo sapiens	96-98
17640564-3	2007	Herein we report that an herb-derived polyphenolic compound, curcumin, elicited a dose- and time-dependent increase in AR expression.	Curcumin	61-69	aldo-keto reductase family 1 member B	Homo sapiens	119-121
17640564-4	2007	Inhibition of phosphatidylinositol 3-kinase (PI3K) and p38 mitogen-activated protein kinase (MAPK) significantly suppressed the curcumin-augmented mRNA levels and promoter activity of the AR gene.	Curcumin	128-136	mitogen-activated protein kinase 14	Homo sapiens	55-91
17640564-9	2007	Taken together, the activation of PI3K and p38 MAPK by curcumin augmented the expression of the AR gene via Nrf2, and increased AR activity may be an important cellular response against oxidative stress.	Curcumin	55-63	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
17640564-4	2007	Inhibition of phosphatidylinositol 3-kinase (PI3K) and p38 mitogen-activated protein kinase (MAPK) significantly suppressed the curcumin-augmented mRNA levels and promoter activity of the AR gene.	Curcumin	128-136	aldo-keto reductase family 1 member B	Homo sapiens	188-190
17640564-6	2007	Curcumin accelerated the nuclear translocation of nuclear factor-erythroid 2-related factor 2 (Nrf2), and overexpression of Nrf2, but not the dominant negative Nrf2, enhanced the promoter activity of the AR gene.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	50-93
17640567-3	2007	We found that TNF-mediated NF-kappaB activation was inhibited by curcumin; and glutathione reversed the inhibition.	Curcumin	65-73	tumor necrosis factor	Homo sapiens	14-17
17640564-6	2007	Curcumin accelerated the nuclear translocation of nuclear factor-erythroid 2-related factor 2 (Nrf2), and overexpression of Nrf2, but not the dominant negative Nrf2, enhanced the promoter activity of the AR gene.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	95-99
17640567-4	2007	Similarly, suppression of TNF-induced AKT activation by curcumin was also abrogated by glutathione.	Curcumin	56-64	tumor necrosis factor	Homo sapiens	26-29
17640567-4	2007	Similarly, suppression of TNF-induced AKT activation by curcumin was also abrogated by glutathione.	Curcumin	56-64	AKT serine/threonine kinase 1	Homo sapiens	38-41
17640567-5	2007	The reducing agent also counteracted the inhibitory effects of curcumin on TNF-induced NF-kappaB-regulated antiapoptotic (Bcl-2, Bcl-xL, IAP1), proliferative (cyclin D1), and proinflammatory (COX-2, iNOS, and MMP-9) gene products.	Curcumin	63-71	tumor necrosis factor	Homo sapiens	75-78
17640567-5	2007	The reducing agent also counteracted the inhibitory effects of curcumin on TNF-induced NF-kappaB-regulated antiapoptotic (Bcl-2, Bcl-xL, IAP1), proliferative (cyclin D1), and proinflammatory (COX-2, iNOS, and MMP-9) gene products.	Curcumin	63-71	BCL2 apoptosis regulator	Homo sapiens	122-127
17640567-5	2007	The reducing agent also counteracted the inhibitory effects of curcumin on TNF-induced NF-kappaB-regulated antiapoptotic (Bcl-2, Bcl-xL, IAP1), proliferative (cyclin D1), and proinflammatory (COX-2, iNOS, and MMP-9) gene products.	Curcumin	63-71	BCL2 like 1	Homo sapiens	129-135
17640567-5	2007	The reducing agent also counteracted the inhibitory effects of curcumin on TNF-induced NF-kappaB-regulated antiapoptotic (Bcl-2, Bcl-xL, IAP1), proliferative (cyclin D1), and proinflammatory (COX-2, iNOS, and MMP-9) gene products.	Curcumin	63-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	192-197
17640567-6	2007	The suppression of TNF-induced AP-1 activation by curcumin was also reversed by glutathione.	Curcumin	50-58	tumor necrosis factor	Homo sapiens	19-22
17693979-8	2007	It is suggested that CFS patients should be treated with antioxidants, which inhibit the production of NFkappabeta, such as curcumin, N-Acetyl-Cysteine, quercitin, silimarin, lipoic acid and omega-3 fatty acids.	Curcumin	124-132	nuclear factor kappa B subunit 1	Homo sapiens	103-114
17640182-0	2007	A potential role for the vanilloid receptor TRPV1 in the therapeutic effect of curcumin in dinitrobenzene sulphonic acid-induced colitis in mice.	Curcumin	79-87	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	44-49
17640182-7	2007	), a TRPV1 receptor antagonist, completely abolished the protective effects of curcumin.	Curcumin	79-87	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	5-10
17640182-11	2007	As sensitization of the TRPV1 receptor by mediators of inflammation in damaged tissues has been shown previously, our results suggest that in inflamed, but not in normal tissue, curcumin can interact with the TRPV1 receptor to mediate its protective action in DNBS-induced colitis.	Curcumin	178-186	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	24-29
17640182-11	2007	As sensitization of the TRPV1 receptor by mediators of inflammation in damaged tissues has been shown previously, our results suggest that in inflamed, but not in normal tissue, curcumin can interact with the TRPV1 receptor to mediate its protective action in DNBS-induced colitis.	Curcumin	178-186	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	209-214
17708799-4	2007	RT-PCR showed that RPMI8226 cells expressed survivin, Bcl-2 strongly and Bax slightly; while RPMI8226 cells were treated with curcumin 10 micromol/L for 24 hours, the expressions of survivin, Bcl-2 mRNA were apparently down-regulated, and the expression of Bax mRNA was markedly up-regulated.	Curcumin	126-134	BCL2 apoptosis regulator	Homo sapiens	54-59
17708799-4	2007	RT-PCR showed that RPMI8226 cells expressed survivin, Bcl-2 strongly and Bax slightly; while RPMI8226 cells were treated with curcumin 10 micromol/L for 24 hours, the expressions of survivin, Bcl-2 mRNA were apparently down-regulated, and the expression of Bax mRNA was markedly up-regulated.	Curcumin	126-134	BCL2 apoptosis regulator	Homo sapiens	192-197
17708799-4	2007	RT-PCR showed that RPMI8226 cells expressed survivin, Bcl-2 strongly and Bax slightly; while RPMI8226 cells were treated with curcumin 10 micromol/L for 24 hours, the expressions of survivin, Bcl-2 mRNA were apparently down-regulated, and the expression of Bax mRNA was markedly up-regulated.	Curcumin	126-134	BCL2 associated X, apoptosis regulator	Homo sapiens	257-260
17708799-6	2007	The mechanism of antitumous effect of curcumin may be related to down-regulation of survivin, Bcl-2 mRNA and up-regulation of Bax mRNA.	Curcumin	38-46	BCL2 apoptosis regulator	Homo sapiens	94-99
17708799-6	2007	The mechanism of antitumous effect of curcumin may be related to down-regulation of survivin, Bcl-2 mRNA and up-regulation of Bax mRNA.	Curcumin	38-46	BCL2 associated X, apoptosis regulator	Homo sapiens	126-129
17708799-0	2007	[Effect of curcumin on expression of survivin, Bcl-2 and Bax in human multiple myeloma cell line].	Curcumin	11-19	BCL2 apoptosis regulator	Homo sapiens	47-52
17708799-0	2007	[Effect of curcumin on expression of survivin, Bcl-2 and Bax in human multiple myeloma cell line].	Curcumin	11-19	BCL2 associated X, apoptosis regulator	Homo sapiens	57-60
18021535-18	2007	Curcumin down-regulated the expressions of TNF-alpha mRNA and IL-8 mRNA and content of TNF-alpha and IL-8.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	43-52
18021535-18	2007	Curcumin down-regulated the expressions of TNF-alpha mRNA and IL-8 mRNA and content of TNF-alpha and IL-8.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	87-96
17395690-0	2007	Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways.	Curcumin	14-22	AKT serine/threonine kinase 1	Homo sapiens	127-130
17666914-0	2007	Curcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cells.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	46-55
17666914-4	2007	Curcumin blocked the activation of NF-kappaB by TNF-alpha.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	48-57
17666914-5	2007	Curcumin also reduced the intracellular reactive oxygen species (ROS), monocyte adhesion, phosphorylation of c-Jun N-terminal kinase (JNK), p38, and signal transducer and activator of transcription (STAT)-3 in TNF-alpha-stimulated HUVECs.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	109-132
17666914-5	2007	Curcumin also reduced the intracellular reactive oxygen species (ROS), monocyte adhesion, phosphorylation of c-Jun N-terminal kinase (JNK), p38, and signal transducer and activator of transcription (STAT)-3 in TNF-alpha-stimulated HUVECs.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	134-137
17666914-5	2007	Curcumin also reduced the intracellular reactive oxygen species (ROS), monocyte adhesion, phosphorylation of c-Jun N-terminal kinase (JNK), p38, and signal transducer and activator of transcription (STAT)-3 in TNF-alpha-stimulated HUVECs.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	140-143
17666914-5	2007	Curcumin also reduced the intracellular reactive oxygen species (ROS), monocyte adhesion, phosphorylation of c-Jun N-terminal kinase (JNK), p38, and signal transducer and activator of transcription (STAT)-3 in TNF-alpha-stimulated HUVECs.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	149-206
17666914-5	2007	Curcumin also reduced the intracellular reactive oxygen species (ROS), monocyte adhesion, phosphorylation of c-Jun N-terminal kinase (JNK), p38, and signal transducer and activator of transcription (STAT)-3 in TNF-alpha-stimulated HUVECs.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	210-219
17666914-6	2007	The expression of intracellular cell adhesion molecule (ICAM)-1, monocyte chemoattractant protein (MCP)-1, and interleukin (IL)-8 were attenuated by curcumin at both mRNA and protein level.	Curcumin	149-157	C-X-C motif chemokine ligand 8	Homo sapiens	111-129
17666914-8	2007	We suggest that curcumin could contribute to protection against the adverse vascular effect of the proinflammatory response through the modulation of p38 and STAT-3 in addition to NF-kappaB and JNK in endothelial cells.	Curcumin	16-24	mitogen-activated protein kinase 14	Homo sapiens	150-153
17666914-8	2007	We suggest that curcumin could contribute to protection against the adverse vascular effect of the proinflammatory response through the modulation of p38 and STAT-3 in addition to NF-kappaB and JNK in endothelial cells.	Curcumin	16-24	signal transducer and activator of transcription 3	Homo sapiens	158-164
17666914-8	2007	We suggest that curcumin could contribute to protection against the adverse vascular effect of the proinflammatory response through the modulation of p38 and STAT-3 in addition to NF-kappaB and JNK in endothelial cells.	Curcumin	16-24	mitogen-activated protein kinase 8	Homo sapiens	194-197
17596214-0	2007	Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors.	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-83
17596214-6	2007	Curcumin reduced cell survival in a p53- and caspase-independent manner, an effect correlated with the inhibition of AP-1 and NFkappaB signaling pathways via prevention of constitutive JNK and Akt activation.	Curcumin	0-8	tumor protein p53	Homo sapiens	36-39
17596214-6	2007	Curcumin reduced cell survival in a p53- and caspase-independent manner, an effect correlated with the inhibition of AP-1 and NFkappaB signaling pathways via prevention of constitutive JNK and Akt activation.	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	117-121
17596214-6	2007	Curcumin reduced cell survival in a p53- and caspase-independent manner, an effect correlated with the inhibition of AP-1 and NFkappaB signaling pathways via prevention of constitutive JNK and Akt activation.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	185-188
17596214-6	2007	Curcumin reduced cell survival in a p53- and caspase-independent manner, an effect correlated with the inhibition of AP-1 and NFkappaB signaling pathways via prevention of constitutive JNK and Akt activation.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	193-196
17596214-7	2007	Curcumin-sensitized glioma cells to several clinically utilized chemotherapeutic agents (cisplatin, etoposide, camptothecin, and doxorubicin) and radiation, effects correlated with reduced expression of bcl-2 and IAP family members as well as DNA repair enzymes (MGMT, DNA-PK, Ku70, Ku80, and ERCC-1).	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	203-208
17596214-7	2007	Curcumin-sensitized glioma cells to several clinically utilized chemotherapeutic agents (cisplatin, etoposide, camptothecin, and doxorubicin) and radiation, effects correlated with reduced expression of bcl-2 and IAP family members as well as DNA repair enzymes (MGMT, DNA-PK, Ku70, Ku80, and ERCC-1).	Curcumin	0-8	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	269-275
17395690-9	2007	It is interesting that activation of the Akt pathway inhibited curcumin-induced autophagy and cytotoxicity, whereas inhibition of the ERK1/2 pathway inhibited curcumin-induced autophagy and induced apoptosis, thus resulting in enhanced cytotoxicity.	Curcumin	63-71	AKT serine/threonine kinase 1	Homo sapiens	41-44
17395690-9	2007	It is interesting that activation of the Akt pathway inhibited curcumin-induced autophagy and cytotoxicity, whereas inhibition of the ERK1/2 pathway inhibited curcumin-induced autophagy and induced apoptosis, thus resulting in enhanced cytotoxicity.	Curcumin	159-167	mitogen-activated protein kinase 3	Homo sapiens	134-140
17197075-4	2007	To address the molecular mechanisms involved, we performed experiments with specific inhibitors against putative targets of curcumin, including IkappaB kinase (IKK), epidermal growth factor receptor (EGFR), phosphatidylinositol-3 kinase (PI3K)/Akt, and matrix metalloproteinases (MMPs).	Curcumin	124-132	AKT serine/threonine kinase 1	Rattus norvegicus	244-247
17583825-0	2007	Curcumin decreases acid sphingomyelinase activity in colon cancer Caco-2 cells.	Curcumin	0-8	sphingomyelin phosphodiesterase 1	Homo sapiens	19-40
17583825-9	2007	Analysis of the hydrolytic products revealed that the activity was derived from acid sphingomyelinase not from phospholipase D. The curcumin-induced reduction of acid SMase required more than 8 h stimulation.	Curcumin	132-140	sphingomyelin phosphodiesterase 1	Homo sapiens	80-101
17583825-10	2007	Western blotting showed reduced acid sphingomyelinase protein after curcumin stimulation.	Curcumin	68-76	sphingomyelin phosphodiesterase 1	Homo sapiens	32-53
17583825-13	2007	In the concentrations inhibiting acid sphingomyelinase, curcumin inhibited DNA synthesis and induced cell death.	Curcumin	56-64	sphingomyelin phosphodiesterase 1	Homo sapiens	33-54
17583825-14	2007	In conclusion, curcumin inhibits acid sphingomyelinase and the effect might be involved in its antiproliferative property against colon cancer cells.	Curcumin	15-23	sphingomyelin phosphodiesterase 1	Homo sapiens	33-54
17603281-3	2007	At non-toxic concentrations, curcumin possessing two Michael-reaction acceptors induced HO-1 expression by activating antioxidant response element (ARE) through translocation of the nuclear transcription factor E2-related factor-2 (Nrf2) into the nucleus and also inhibited VSMC growth triggered by 5% FBS in a dose-dependent manner.	Curcumin	29-37	NFE2 like bZIP transcription factor 2	Rattus norvegicus	232-236
17603281-7	2007	In human aortic smooth muscle cells (HASMCs), curcumin also inhibited growth triggered by TNF-alpha and increased p21(WAF1/CIP1) expression via HO-1-dependent manner.	Curcumin	46-54	tumor necrosis factor	Homo sapiens	90-99
17603281-7	2007	In human aortic smooth muscle cells (HASMCs), curcumin also inhibited growth triggered by TNF-alpha and increased p21(WAF1/CIP1) expression via HO-1-dependent manner.	Curcumin	46-54	cyclin dependent kinase inhibitor 1A	Homo sapiens	114-117
17603281-7	2007	In human aortic smooth muscle cells (HASMCs), curcumin also inhibited growth triggered by TNF-alpha and increased p21(WAF1/CIP1) expression via HO-1-dependent manner.	Curcumin	46-54	cyclin dependent kinase inhibitor 1A	Homo sapiens	118-127
17603281-8	2007	Our findings suggest that curcumin has an ability to induce HO-1 expression, presumably through Nrf2-dependent ARE activation, in rat VSMCs and HASMCs, and provide evidence that the antiproliferative effect of curcumin is considerably linked to its ability to induce HO-1 expression.	Curcumin	26-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	96-100
17197075-6	2007	Western blot analysis and gelatin zymography revealed that curcumin, but not berberine, has an inhibitory effect on the phosphorylation of Akt and enzymatic activity of MMP-2 in TR-LE cells.	Curcumin	59-67	AKT serine/threonine kinase 1	Rattus norvegicus	139-142
17197075-7	2007	These results suggest that curcumin exerts its inhibitory effect on lymphangiogenesis partly through Akt and MMP-2.	Curcumin	27-35	AKT serine/threonine kinase 1	Rattus norvegicus	101-104
17277231-6	2007	Smac N7 peptide enhanced curcumin-induced apoptosis, whereas Smac siRNA inhibited the effects of curcumin on apoptosis.	Curcumin	97-105	diablo, IAP-binding mitochondrial protein	Mus musculus	61-65
17433521-4	2007	Curcumin inhibited CYP1A2 (IC(50), 40.0 microM), CYP3A4 (IC(50), 16.3 microM), CYP2D6 (IC(50), 50.3 microM), CYP2C9 (IC(50), 4.3 microM) and CYP2B6 (IC(50), 24.5 microM).	Curcumin	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	49-55
17433521-4	2007	Curcumin inhibited CYP1A2 (IC(50), 40.0 microM), CYP3A4 (IC(50), 16.3 microM), CYP2D6 (IC(50), 50.3 microM), CYP2C9 (IC(50), 4.3 microM) and CYP2B6 (IC(50), 24.5 microM).	Curcumin	0-8	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	79-85
17433521-5	2007	Curcumin showed a competitive type of inhibition towards CYP1A2, CYP3A4 and CYP2B6, whereas a non-competitive type of inhibition was observed with respect to CYP2D6 and CYP2C9.	Curcumin	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	65-71
17433521-6	2007	The inhibitory activity towards CYP3A4, shown by curcumin may have implications for drug-drug interactions in the intestines, in case of high exposure of the intestines to curcumin upon oral administration.	Curcumin	49-57	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	32-38
17433521-6	2007	The inhibitory activity towards CYP3A4, shown by curcumin may have implications for drug-drug interactions in the intestines, in case of high exposure of the intestines to curcumin upon oral administration.	Curcumin	172-180	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	32-38
17383825-5	2007	Indicators of necrosis (alanine aminotransferase) and cholestasis (gamma-glutamyl transpeptidase and bilirubins) resulted in significant increases after CCl4 intoxication, but these effects were prevented by curcumin treatment.	Curcumin	208-216	C-C motif chemokine ligand 4	Rattus norvegicus	153-157
17383825-11	2007	Accordingly, these proteins were increased by CCl4 and this effect was abolished by curcumin.	Curcumin	84-92	C-C motif chemokine ligand 4	Rattus norvegicus	46-50
17383825-12	2007	Administration of CCl4 induced the translocation of NF-kappaB to the nucleus; CCl4 induced NF-kappaB DNA binding activity was blocked by curcumin treatment.	Curcumin	137-145	C-C motif chemokine ligand 4	Rattus norvegicus	18-22
17383825-12	2007	Administration of CCl4 induced the translocation of NF-kappaB to the nucleus; CCl4 induced NF-kappaB DNA binding activity was blocked by curcumin treatment.	Curcumin	137-145	C-C motif chemokine ligand 4	Rattus norvegicus	78-82
17270371-3	2007	In this study, we investigated the affects of C. longa, C. zedoaria from Japan and curcumin on CYP3A4.	Curcumin	83-91	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	95-101
17270371-5	2007	Caco-2 cells were treated with methanol extracts from two Curcuma rhizomes (0.1mg/ml) or curcumin (30 microM) for 72 h. Both extracts significantly decreased the activity of CYP3A4 by about 85-98%.	Curcumin	89-97	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	174-180
17270371-8	2007	Otherwise, curcumin treatment caused a 30-40% decrease in CYP3A4 catalytic activity and a 38% decrease in CYP3A4 protein expression.	Curcumin	11-19	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	58-64
17270371-8	2007	Otherwise, curcumin treatment caused a 30-40% decrease in CYP3A4 catalytic activity and a 38% decrease in CYP3A4 protein expression.	Curcumin	11-19	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	106-112
17277231-2	2007	The objective of this study was to examine the molecular mechanisms by which multidomain pro-apoptotic Bcl-2 family members Bax and Bak regulate curcumin-induced apoptosis using mouse embryonic fibroblasts (MEFs) deficient in Bax, Bak or both genes.	Curcumin	145-153	B cell leukemia/lymphoma 2	Mus musculus	103-108
17277231-3	2007	Curcumin treatment resulted an increase in the protein levels of both Bax and Bak, and mitochondrial translocation and activation of Bax in MEFs to trigger drop in mitochondrial membrane potential, cytosolic release of apoptogenic molecules [cytochrome c and second mitochondria-derived activator of caspases (Smac)/direct inhibitor of apoptosis protein-binding protein with low isoelectric point], activation of caspase-9 and caspase-3 and ultimately apoptosis.	Curcumin	0-8	diablo, IAP-binding mitochondrial protein	Mus musculus	310-314
17277231-4	2007	Furthermore, MEFs derived from Bax and Bak double-knockout (DKO) mice exhibited even greater protection against curcumin-induced release of cytochrome c and Smac, activation of caspase-3 and caspase-9 and induction of apoptosis compared with wild-type MEFs or single-knockout Bax(-/-) or Bak(-/-) MEFs.	Curcumin	112-120	diablo, IAP-binding mitochondrial protein	Mus musculus	157-161
17277231-8	2007	The present study demonstrates the role of Bax and Bak as a critical regulator of curcumin-induced apoptosis and over-expression of Smac as interventional approaches to deal with Bax- and/or Bak-deficient chemoresistant cancers for curcumin-based therapy.	Curcumin	232-240	diablo, IAP-binding mitochondrial protein	Mus musculus	132-136
17277231-6	2007	Smac N7 peptide enhanced curcumin-induced apoptosis, whereas Smac siRNA inhibited the effects of curcumin on apoptosis.	Curcumin	25-33	diablo, IAP-binding mitochondrial protein	Mus musculus	0-4
17545551-0	2007	Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-107
17545551-1	2007	PURPOSE: Curcumin, a component of turmeric, has been shown to suppress inflammation and angiogenesis largely by inhibiting the transcription factor nuclear factor-kappaB (NF-kappaB).	Curcumin	9-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	148-169
17545551-1	2007	PURPOSE: Curcumin, a component of turmeric, has been shown to suppress inflammation and angiogenesis largely by inhibiting the transcription factor nuclear factor-kappaB (NF-kappaB).	Curcumin	9-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	171-180
17545551-6	2007	RESULTS: Curcumin inhibited inducible NF-kappaB activation and suppressed proliferation in vitro.	Curcumin	9-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	38-47
17392282-0	2007	Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	74-79
17392282-6	2007	Curcumin down-regulated the Bax level while augmenting Bcl-2 expression in these cells, thereby protecting the immunocytes from tumor-induced apoptosis.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	28-31
17392282-6	2007	Curcumin down-regulated the Bax level while augmenting Bcl-2 expression in these cells, thereby protecting the immunocytes from tumor-induced apoptosis.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	55-60
17549234-0	2007	Curcumin in cell death processes: a challenge for CAM of age-related pathologies.	Curcumin	0-8	calmodulin 3	Homo sapiens	50-53
17499312-0	2007	The potentiation of curcumin on insulin-like growth factor-1 action in MCF-7 human breast carcinoma cells.	Curcumin	20-28	insulin like growth factor 1	Homo sapiens	32-60
17434257-6	2007	The anti-inflammatory agent curcumin blocked VIP-induced COX-2 expression in all cell lines studied supporting the involvement of nuclear factor-kappaB (NFkappaB) in such a response.	Curcumin	28-36	vasoactive intestinal peptide	Homo sapiens	45-48
17434257-6	2007	The anti-inflammatory agent curcumin blocked VIP-induced COX-2 expression in all cell lines studied supporting the involvement of nuclear factor-kappaB (NFkappaB) in such a response.	Curcumin	28-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	57-62
17434257-6	2007	The anti-inflammatory agent curcumin blocked VIP-induced COX-2 expression in all cell lines studied supporting the involvement of nuclear factor-kappaB (NFkappaB) in such a response.	Curcumin	28-36	nuclear factor kappa B subunit 1	Homo sapiens	130-151
17434257-6	2007	The anti-inflammatory agent curcumin blocked VIP-induced COX-2 expression in all cell lines studied supporting the involvement of nuclear factor-kappaB (NFkappaB) in such a response.	Curcumin	28-36	nuclear factor kappa B subunit 1	Homo sapiens	153-161
17499312-4	2007	The aim of the present study was to investigate whether the growth inhibitory effects of curcumin were related to changes of the IGF-1 system in MCF-7 cells.	Curcumin	89-97	insulin like growth factor 1	Homo sapiens	129-134
17499312-6	2007	However, curcumin exhibited a potent ability to blunt IGF-1-stimulated MCF-7 cell growth and reverse the IGF-1-induced apoptosis resistance.	Curcumin	9-17	insulin like growth factor 1	Homo sapiens	54-59
17171638-0	2007	Curcumin-induced GADD153 upregulation: modulation by glutathione.	Curcumin	0-8	DNA damage inducible transcript 3	Homo sapiens	17-24
17499312-6	2007	However, curcumin exhibited a potent ability to blunt IGF-1-stimulated MCF-7 cell growth and reverse the IGF-1-induced apoptosis resistance.	Curcumin	9-17	insulin like growth factor 1	Homo sapiens	105-110
17171638-1	2007	As we reported previously, GADD153 is upregulated in colon cancer cells exposed to curcumin.	Curcumin	83-91	DNA damage inducible transcript 3	Homo sapiens	27-34
17171638-2	2007	In the present study, we ascertained the involvement of glutathione and certain sulfhydryl enzymes associated with signal transduction in mediating the effect of curcumin on GADD153.	Curcumin	162-170	DNA damage inducible transcript 3	Homo sapiens	174-181
17499312-8	2007	Curcumin decreased the secretion of IGF-1 with a concomitant increase of IGFBP-3 in a dose-dependent manner.	Curcumin	0-8	insulin like growth factor 1	Homo sapiens	36-41
17171638-3	2007	Curcumin-induced GADD153 gene upregulation was attenuated by reduced glutathione (GSH) or N-acetylcysteine (NAC) and potentiated by the glutathione synthesis inhibitor, L-buthionine-(S,R)-sulfoximine (BSO).	Curcumin	0-8	DNA damage inducible transcript 3	Homo sapiens	17-24
17499312-9	2007	Receptor tyrosine kinase assays revealed that IGF-1-stimulated IGF-1R tyrosine kinase activation was also abrogated by curcumin in a dose-dependent manner.	Curcumin	119-127	insulin like growth factor 1	Homo sapiens	46-51
17171638-6	2007	In affecting the thiol redox status, curcumin caused activation of certain sulfhydryl enzymes involved in signal transduction linked to GADD153 expression.	Curcumin	37-45	DNA damage inducible transcript 3	Homo sapiens	136-143
17171638-8	2007	Furthermore, selective inhibitors of PI3K and PKC-delta attenuated curcumin-induced GADD153 upregulation.	Curcumin	67-75	DNA damage inducible transcript 3	Homo sapiens	84-91
17499312-11	2007	In conclusion, the inhibition of cell growth and induction of apoptosis by curcumin in MCF-7 cells might be mediated, at least partially, by its ability to down-regulate the IGF-1 axis.	Curcumin	75-83	insulin like growth factor 1	Homo sapiens	174-179
17171638-9	2007	Collectively, these findings suggest that a regulatory thiol redox-sensitive signaling cascade exists in the molecular pathway leading to induction of GADD153 expression as caused by curcumin.	Curcumin	183-191	DNA damage inducible transcript 3	Homo sapiens	151-158
17449203-8	2007	While the introduction of a wild-type Nrf2 expression construct augmented the promoter activity of the GSTP1 gene, co-expression of a dominant-negative Nrf2 abolished the responsiveness to curcumin.	Curcumin	189-197	NFE2 like bZIP transcription factor 2	Homo sapiens	152-156
17531121-17	2007	Hoechst 33258 staining showed that curcumin induced the apoptosis of culture-activated HSCs and significantly increased pro-apoptotic Bax expression and reduced anti-apoptotic Bcl-2 expression.	Curcumin	35-43	BCL2, apoptosis regulator	Rattus norvegicus	176-181
17531121-18	2007	Cyclin D1 gene, activated NFkappaB p65 protein and TGFbetaR-I protein expression were down-regulated significantly by curcumin.	Curcumin	118-126	cyclin D1	Rattus norvegicus	0-9
17531121-18	2007	Cyclin D1 gene, activated NFkappaB p65 protein and TGFbetaR-I protein expression were down-regulated significantly by curcumin.	Curcumin	118-126	synaptotagmin 1	Rattus norvegicus	35-38
17303117-9	2007	In cultured astrocytes, curcumin significantly inhibited inducible nitric oxide synthase (iNOS) expression and NO(x) (Nitrites/nitrates contents) production induced by lipopolysaccharide (LPS)/tumor necrosis factor alpha (TNF(alpha)).	Curcumin	24-32	nitric oxide synthase 2	Rattus norvegicus	57-88
17291458-0	2007	Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis.	Curcumin	39-47	nuclear factor kappa B subunit 1	Homo sapiens	15-24
17291458-3	2007	The purpose of this study was to examine the effects of curcumin (diferuloylmethane), a pharmacologically safe phytochemical agent with potent anti-inflammatory properties on IL-1beta and TNF-alpha signalling pathways in human articular chondrocytes maintained in vitro.	Curcumin	56-64	interleukin 1 beta	Homo sapiens	175-183
17291458-3	2007	The purpose of this study was to examine the effects of curcumin (diferuloylmethane), a pharmacologically safe phytochemical agent with potent anti-inflammatory properties on IL-1beta and TNF-alpha signalling pathways in human articular chondrocytes maintained in vitro.	Curcumin	56-64	tumor necrosis factor	Homo sapiens	188-197
17291458-3	2007	The purpose of this study was to examine the effects of curcumin (diferuloylmethane), a pharmacologically safe phytochemical agent with potent anti-inflammatory properties on IL-1beta and TNF-alpha signalling pathways in human articular chondrocytes maintained in vitro.	Curcumin	66-83	interleukin 1 beta	Homo sapiens	175-183
17291458-3	2007	The purpose of this study was to examine the effects of curcumin (diferuloylmethane), a pharmacologically safe phytochemical agent with potent anti-inflammatory properties on IL-1beta and TNF-alpha signalling pathways in human articular chondrocytes maintained in vitro.	Curcumin	66-83	tumor necrosis factor	Homo sapiens	188-197
17291458-6	2007	The effects of curcumin on the expression, phosphorylation and nuclear translocation of protein components of the NF-kappaB system were studied by western blotting and immunofluorescence, respectively.	Curcumin	15-23	nuclear factor kappa B subunit 1	Homo sapiens	114-123
17291458-7	2007	Treatment of chondrocytes with curcumin suppressed IL-1beta-induced NF-kappaB activation via inhibition of IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation and p65 nuclear translocation.	Curcumin	31-39	interleukin 1 beta	Homo sapiens	51-59
17291458-7	2007	Treatment of chondrocytes with curcumin suppressed IL-1beta-induced NF-kappaB activation via inhibition of IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation and p65 nuclear translocation.	Curcumin	31-39	nuclear factor kappa B subunit 1	Homo sapiens	68-77
17291458-7	2007	Treatment of chondrocytes with curcumin suppressed IL-1beta-induced NF-kappaB activation via inhibition of IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation and p65 nuclear translocation.	Curcumin	31-39	NFKB inhibitor alpha	Homo sapiens	107-119
17291458-7	2007	Treatment of chondrocytes with curcumin suppressed IL-1beta-induced NF-kappaB activation via inhibition of IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation and p65 nuclear translocation.	Curcumin	31-39	NFKB inhibitor alpha	Homo sapiens	137-149
17291458-8	2007	Curcumin inhibited the IL-1beta-induced stimulation of up-stream protein kinase B Akt.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	23-31
17291458-11	2007	Curcumin also reversed the IL-1beta-induced down-regulation of collagen type II and beta1-integrin receptor expression.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	27-35
17291458-12	2007	These results indicate that curcumin has nutritional potential as a naturally occurring anti-inflammatory agent for treating OA through suppression of NF-kappaB mediated IL-1beta/TNF-alpha catabolic signalling pathways in chondrocytes.	Curcumin	28-36	nuclear factor kappa B subunit 1	Homo sapiens	151-160
17291458-12	2007	These results indicate that curcumin has nutritional potential as a naturally occurring anti-inflammatory agent for treating OA through suppression of NF-kappaB mediated IL-1beta/TNF-alpha catabolic signalling pathways in chondrocytes.	Curcumin	28-36	interleukin 1 beta	Homo sapiens	170-178
17291458-12	2007	These results indicate that curcumin has nutritional potential as a naturally occurring anti-inflammatory agent for treating OA through suppression of NF-kappaB mediated IL-1beta/TNF-alpha catabolic signalling pathways in chondrocytes.	Curcumin	28-36	tumor necrosis factor	Homo sapiens	179-188
17289836-0	2007	Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-kappaB via inhibition of the prosurvival Akt signaling pathway.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	178-183
17289836-0	2007	Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-kappaB via inhibition of the prosurvival Akt signaling pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	273-276
17289836-3	2007	Curcumin inhibited the expression of phospho-Akt (p-Akt), which was not due to activation of phosphatase and tensin homolog deleted on chromosome 10 phosphatase activity by curcumin.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	45-48
17289836-3	2007	Curcumin inhibited the expression of phospho-Akt (p-Akt), which was not due to activation of phosphatase and tensin homolog deleted on chromosome 10 phosphatase activity by curcumin.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	52-55
17289836-6	2007	Furthermore, overexpression of constitutively active Akt1 in cancer cells prevented the inhibition of NF-kappaB by curcumin.	Curcumin	115-123	AKT serine/threonine kinase 1	Homo sapiens	53-57
17289836-9	2007	Because expression of antiapoptotic Bcl-2, Bcl-xL, and X-chromosome-linked inhibitor of apoptosis protein (XIAP) is regulated by NF-kappaB, both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB.	Curcumin	145-153	BCL2 apoptosis regulator	Homo sapiens	36-41
17289836-9	2007	Because expression of antiapoptotic Bcl-2, Bcl-xL, and X-chromosome-linked inhibitor of apoptosis protein (XIAP) is regulated by NF-kappaB, both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB.	Curcumin	145-153	BCL2 like 1	Homo sapiens	43-49
17289836-11	2007	Collectively, these data define a pathway whereby curcumin sensitizes prostate cancer cells to TRAIL by inhibiting Akt-regulated NF-kappaB and NF-kappaB-dependent antiapoptotic Bcl-2, Bcl-xL, and XIAP.	Curcumin	50-58	TNF superfamily member 10	Homo sapiens	95-100
17289836-11	2007	Collectively, these data define a pathway whereby curcumin sensitizes prostate cancer cells to TRAIL by inhibiting Akt-regulated NF-kappaB and NF-kappaB-dependent antiapoptotic Bcl-2, Bcl-xL, and XIAP.	Curcumin	50-58	AKT serine/threonine kinase 1	Homo sapiens	115-118
17289836-11	2007	Collectively, these data define a pathway whereby curcumin sensitizes prostate cancer cells to TRAIL by inhibiting Akt-regulated NF-kappaB and NF-kappaB-dependent antiapoptotic Bcl-2, Bcl-xL, and XIAP.	Curcumin	50-58	BCL2 apoptosis regulator	Homo sapiens	177-182
17289836-11	2007	Collectively, these data define a pathway whereby curcumin sensitizes prostate cancer cells to TRAIL by inhibiting Akt-regulated NF-kappaB and NF-kappaB-dependent antiapoptotic Bcl-2, Bcl-xL, and XIAP.	Curcumin	50-58	BCL2 like 1	Homo sapiens	184-190
17372590-7	2007	Curcumin interrupts PDGF and EGF signaling demonstrated by inhibiting tyrosine phosphorylation of PDGF-betaR and EGFR and by reducing the levels of phosphorylated phosphatidylinositol-3 kinase (PI-3K/AKT), extracellular signal-regulated kinase (ERK) and the Jun N-terminal kinase (JNK).	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	200-203
17372590-7	2007	Curcumin interrupts PDGF and EGF signaling demonstrated by inhibiting tyrosine phosphorylation of PDGF-betaR and EGFR and by reducing the levels of phosphorylated phosphatidylinositol-3 kinase (PI-3K/AKT), extracellular signal-regulated kinase (ERK) and the Jun N-terminal kinase (JNK).	Curcumin	0-8	Eph receptor B1	Rattus norvegicus	206-243
17372590-7	2007	Curcumin interrupts PDGF and EGF signaling demonstrated by inhibiting tyrosine phosphorylation of PDGF-betaR and EGFR and by reducing the levels of phosphorylated phosphatidylinositol-3 kinase (PI-3K/AKT), extracellular signal-regulated kinase (ERK) and the Jun N-terminal kinase (JNK).	Curcumin	0-8	Eph receptor B1	Rattus norvegicus	245-248
17303117-9	2007	In cultured astrocytes, curcumin significantly inhibited inducible nitric oxide synthase (iNOS) expression and NO(x) (Nitrites/nitrates contents) production induced by lipopolysaccharide (LPS)/tumor necrosis factor alpha (TNF(alpha)).	Curcumin	24-32	nitric oxide synthase 2	Rattus norvegicus	90-94
17303117-9	2007	In cultured astrocytes, curcumin significantly inhibited inducible nitric oxide synthase (iNOS) expression and NO(x) (Nitrites/nitrates contents) production induced by lipopolysaccharide (LPS)/tumor necrosis factor alpha (TNF(alpha)).	Curcumin	24-32	tumor necrosis factor	Rattus norvegicus	193-220
17303117-9	2007	In cultured astrocytes, curcumin significantly inhibited inducible nitric oxide synthase (iNOS) expression and NO(x) (Nitrites/nitrates contents) production induced by lipopolysaccharide (LPS)/tumor necrosis factor alpha (TNF(alpha)).	Curcumin	24-32	tumor necrosis factor	Rattus norvegicus	222-232
17437639-9	2007	Curcumin also inhibited diabetes-induced elevation in the levels of IL-1beta, VEGF and NF-kB.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	68-76
21179765-0	2007	[The relationship between the effects of curcumin on cerebral ischemia/reperfusion injury and immediately genic expressions of fos, Jun and NF-kappaB in hippocampal CA1 area and its significance in gerbils].	Curcumin	41-49	nuclear factor kappa B subunit 1	Homo sapiens	140-149
21179765-1	2007	AIM: To explore the relationship between the effects of curcumin on cerebral ischemic/reperfusion injury and immediately genic expressions of Fos, Jun and NF-kappaB in hippocampal CA1 area.	Curcumin	56-64	nuclear factor kappa B subunit 1	Homo sapiens	155-164
21179765-6	2007	CONCLUSION: Curcumin can significantly protect neurons against cerebral ischemia, increasing the expression Fos and decreasing the expression of Jun and NF-kappaB may be the protective mechanisms.	Curcumin	12-20	nuclear factor kappa B subunit 1	Homo sapiens	153-162
17373813-7	2007	Curcumin also significantly blocked the TNF-alpha-induced NF-kappaB activation at doses of 10 and 20 microM (p &lt; 0.05).	Curcumin	0-8	tumor necrosis factor	Homo sapiens	40-49
17373813-7	2007	Curcumin also significantly blocked the TNF-alpha-induced NF-kappaB activation at doses of 10 and 20 microM (p &lt; 0.05).	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	58-67
17373813-9	2007	These results suggest that apple extracts and curcumin have the capabilities of inhibiting TNF-alpha-induced NF-kappaB activation of MCF-7 cells by inhibiting the proteasomal activities instead of IkappaB kinase (IKK) activation.	Curcumin	46-54	tumor necrosis factor	Homo sapiens	91-100
17373813-9	2007	These results suggest that apple extracts and curcumin have the capabilities of inhibiting TNF-alpha-induced NF-kappaB activation of MCF-7 cells by inhibiting the proteasomal activities instead of IkappaB kinase (IKK) activation.	Curcumin	46-54	nuclear factor kappa B subunit 1	Homo sapiens	112-118
17464095-4	2007	Both curcumin and complex treatment in sham-irradiated mice decreased the levels of GSH and total thiols, whereas there was an increase in the levels of catalase, GST and SOD compared to normal control.	Curcumin	5-13	catalase	Mus musculus	153-161
17464095-5	2007	Under the influence of irradiation, both curcumin and complex treatment protected the decline in the levels of GSH, GST, SOD, catalase and total thiols, and inhibited radiation-induced lipid peroxidation.	Curcumin	41-49	catalase	Mus musculus	126-134
17439648-8	2007	Further, nanocurcumin"s mechanisms of action on pancreatic cancer cells mirror that of free curcumin, including induction of cellular apoptosis, blockade of nuclear factor kappa B (NFkappaB) activation, and downregulation of steady state levels of multiple pro-inflammatory cytokines (IL-6, IL-8, and TNFalpha).	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	157-179
17439648-8	2007	Further, nanocurcumin"s mechanisms of action on pancreatic cancer cells mirror that of free curcumin, including induction of cellular apoptosis, blockade of nuclear factor kappa B (NFkappaB) activation, and downregulation of steady state levels of multiple pro-inflammatory cytokines (IL-6, IL-8, and TNFalpha).	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	181-189
17439648-8	2007	Further, nanocurcumin"s mechanisms of action on pancreatic cancer cells mirror that of free curcumin, including induction of cellular apoptosis, blockade of nuclear factor kappa B (NFkappaB) activation, and downregulation of steady state levels of multiple pro-inflammatory cytokines (IL-6, IL-8, and TNFalpha).	Curcumin	13-21	interleukin 6	Homo sapiens	285-289
17439648-8	2007	Further, nanocurcumin"s mechanisms of action on pancreatic cancer cells mirror that of free curcumin, including induction of cellular apoptosis, blockade of nuclear factor kappa B (NFkappaB) activation, and downregulation of steady state levels of multiple pro-inflammatory cytokines (IL-6, IL-8, and TNFalpha).	Curcumin	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	291-295
17439648-8	2007	Further, nanocurcumin"s mechanisms of action on pancreatic cancer cells mirror that of free curcumin, including induction of cellular apoptosis, blockade of nuclear factor kappa B (NFkappaB) activation, and downregulation of steady state levels of multiple pro-inflammatory cytokines (IL-6, IL-8, and TNFalpha).	Curcumin	13-21	tumor necrosis factor	Homo sapiens	301-309
17240359-0	2007	Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	144-147
17440100-3	2007	Curcumin, a component of turmeric (Curcuma longa), is one such agent that has been shown to suppress the transcription factor nuclear factor-kappaB (NF-kappaB), which is implicated in proliferation, survival, angiogenesis, and chemoresistance.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	149-158
17440100-5	2007	In vitro, curcumin inhibited the proliferation of various pancreatic cancer cell lines, potentiated the apoptosis induced by gemcitabine, and inhibited constitutive NF-kappaB activation in the cells.	Curcumin	10-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	165-174
17440100-8	2007	Overall, our results suggest that curcumin potentiates the antitumor effects of gemcitabine in pancreatic cancer by suppressing proliferation, angiogenesis, NF-kappaB, and NF-kappaB-regulated gene products.	Curcumin	34-42	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-166
17440100-8	2007	Overall, our results suggest that curcumin potentiates the antitumor effects of gemcitabine in pancreatic cancer by suppressing proliferation, angiogenesis, NF-kappaB, and NF-kappaB-regulated gene products.	Curcumin	34-42	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	172-181
17461496-0	2007	Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes.	Curcumin	21-29	selenoprotein K	Rattus norvegicus	123-141
17461496-10	2007	Curcumin also decreased the activity of inducible NO synthase (iNOS) in liver after reperfusion, but had no effect on the level of endothelial NO synthase (eNOS) after reperfusion in liver.	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	40-61
17240359-6	2007	We found that curcumin enhanced the expression of tumor cyclin-dependent kinase (CDK) inhibitors p21 and p27 as well as tumor suppressor protein p53 but suppressed the expression of retinoblastoma protein.	Curcumin	14-22	cyclin dependent kinase inhibitor 1A	Homo sapiens	97-100
17240359-6	2007	We found that curcumin enhanced the expression of tumor cyclin-dependent kinase (CDK) inhibitors p21 and p27 as well as tumor suppressor protein p53 but suppressed the expression of retinoblastoma protein.	Curcumin	14-22	tumor protein p53	Homo sapiens	145-148
17332930-0	2007	Involvement of Bcl-2 family members, phosphatidylinositol 3"-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer.	Curcumin	97-105	BCL2 apoptosis regulator	Homo sapiens	15-20
17332930-11	2007	Overexpression of constitutively active AKT inhibited curcumin-induced p53 translocation to mitochondria, and Smac release to cytoplasm, whereas inhibition of AKT by dominant negative AKT enhanced curcumin-induced p53 translocation to mitochondria and Smac release.	Curcumin	54-62	AKT serine/threonine kinase 1	Homo sapiens	40-43
17332930-0	2007	Involvement of Bcl-2 family members, phosphatidylinositol 3"-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer.	Curcumin	97-105	AKT serine/threonine kinase 1	Homo sapiens	68-71
17332930-11	2007	Overexpression of constitutively active AKT inhibited curcumin-induced p53 translocation to mitochondria, and Smac release to cytoplasm, whereas inhibition of AKT by dominant negative AKT enhanced curcumin-induced p53 translocation to mitochondria and Smac release.	Curcumin	54-62	tumor protein p53	Homo sapiens	71-74
17332930-11	2007	Overexpression of constitutively active AKT inhibited curcumin-induced p53 translocation to mitochondria, and Smac release to cytoplasm, whereas inhibition of AKT by dominant negative AKT enhanced curcumin-induced p53 translocation to mitochondria and Smac release.	Curcumin	54-62	AKT serine/threonine kinase 1	Homo sapiens	159-162
17332930-0	2007	Involvement of Bcl-2 family members, phosphatidylinositol 3"-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer.	Curcumin	97-105	tumor protein p53	Homo sapiens	90-93
17332930-11	2007	Overexpression of constitutively active AKT inhibited curcumin-induced p53 translocation to mitochondria, and Smac release to cytoplasm, whereas inhibition of AKT by dominant negative AKT enhanced curcumin-induced p53 translocation to mitochondria and Smac release.	Curcumin	54-62	AKT serine/threonine kinase 1	Homo sapiens	159-162
17332930-11	2007	Overexpression of constitutively active AKT inhibited curcumin-induced p53 translocation to mitochondria, and Smac release to cytoplasm, whereas inhibition of AKT by dominant negative AKT enhanced curcumin-induced p53 translocation to mitochondria and Smac release.	Curcumin	54-62	tumor protein p53	Homo sapiens	214-217
17332930-4	2007	Curcumin downregulated the expression of Bcl-2, and Bcl-XL and upregulated the expression of p53, Bax, Bak, PUMA, Noxa, and Bim.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	41-46
17332930-11	2007	Overexpression of constitutively active AKT inhibited curcumin-induced p53 translocation to mitochondria, and Smac release to cytoplasm, whereas inhibition of AKT by dominant negative AKT enhanced curcumin-induced p53 translocation to mitochondria and Smac release.	Curcumin	197-205	AKT serine/threonine kinase 1	Homo sapiens	40-43
17332930-11	2007	Overexpression of constitutively active AKT inhibited curcumin-induced p53 translocation to mitochondria, and Smac release to cytoplasm, whereas inhibition of AKT by dominant negative AKT enhanced curcumin-induced p53 translocation to mitochondria and Smac release.	Curcumin	197-205	AKT serine/threonine kinase 1	Homo sapiens	159-162
17332930-4	2007	Curcumin downregulated the expression of Bcl-2, and Bcl-XL and upregulated the expression of p53, Bax, Bak, PUMA, Noxa, and Bim.	Curcumin	0-8	tumor protein p53	Homo sapiens	93-96
17332930-11	2007	Overexpression of constitutively active AKT inhibited curcumin-induced p53 translocation to mitochondria, and Smac release to cytoplasm, whereas inhibition of AKT by dominant negative AKT enhanced curcumin-induced p53 translocation to mitochondria and Smac release.	Curcumin	197-205	AKT serine/threonine kinase 1	Homo sapiens	159-162
17332930-4	2007	Curcumin downregulated the expression of Bcl-2, and Bcl-XL and upregulated the expression of p53, Bax, Bak, PUMA, Noxa, and Bim.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	98-101
17332930-12	2007	Our study establishes a role for AKT in modulating the direct action of p53 on the caspase-dependent mitochondrial death pathway and suggests that these important biological molecules interact at the level of the mitochondria to influence curcumin sensitivity.	Curcumin	239-247	AKT serine/threonine kinase 1	Homo sapiens	33-36
17332930-12	2007	Our study establishes a role for AKT in modulating the direct action of p53 on the caspase-dependent mitochondrial death pathway and suggests that these important biological molecules interact at the level of the mitochondria to influence curcumin sensitivity.	Curcumin	239-247	tumor protein p53	Homo sapiens	72-75
17332930-5	2007	Curcumin upregulated the expression of p53 as well as its phosphorylation at serine 15, and acetylation in a concentration-dependent manner.	Curcumin	0-8	tumor protein p53	Homo sapiens	39-42
17332930-7	2007	Treatment of LNCaP cells with curcumin resulted in translocation of Bax and p53 to mitochondria, production of reactive oxygen species, drop in mitochondrial membrane potential, release of mitochondrial proteins (cytochrome c, Smac/DIABLO and Omi/HtrA2), activation of caspase-3 and induction of apoptosis.	Curcumin	30-38	BCL2 associated X, apoptosis regulator	Homo sapiens	68-71
17332930-7	2007	Treatment of LNCaP cells with curcumin resulted in translocation of Bax and p53 to mitochondria, production of reactive oxygen species, drop in mitochondrial membrane potential, release of mitochondrial proteins (cytochrome c, Smac/DIABLO and Omi/HtrA2), activation of caspase-3 and induction of apoptosis.	Curcumin	30-38	tumor protein p53	Homo sapiens	76-79
17332930-7	2007	Treatment of LNCaP cells with curcumin resulted in translocation of Bax and p53 to mitochondria, production of reactive oxygen species, drop in mitochondrial membrane potential, release of mitochondrial proteins (cytochrome c, Smac/DIABLO and Omi/HtrA2), activation of caspase-3 and induction of apoptosis.	Curcumin	30-38	cytochrome c, somatic	Homo sapiens	213-225
17332930-7	2007	Treatment of LNCaP cells with curcumin resulted in translocation of Bax and p53 to mitochondria, production of reactive oxygen species, drop in mitochondrial membrane potential, release of mitochondrial proteins (cytochrome c, Smac/DIABLO and Omi/HtrA2), activation of caspase-3 and induction of apoptosis.	Curcumin	30-38	caspase 3	Homo sapiens	269-278
17332930-8	2007	Furthermore, curcumin inhibited expression of phosphatidyl-inositol-3 kinase (PI3K) p110 and p85 subunits, and phosphorylation of Ser 473 AKT/PKB.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	138-141
17332930-8	2007	Furthermore, curcumin inhibited expression of phosphatidyl-inositol-3 kinase (PI3K) p110 and p85 subunits, and phosphorylation of Ser 473 AKT/PKB.	Curcumin	13-21	AKT serine/threonine kinase 1	Homo sapiens	142-145
17332930-9	2007	Downregulation of AKT by inhibitors of PI3K (Wortmannin and LY294002) and AKT, or by dominant negative AKT increased curcumin-induced apoptosis, whereas transfection of constitutively active AKT attenuated this effect.	Curcumin	117-125	AKT serine/threonine kinase 1	Homo sapiens	18-21
17431105-9	2007	Tumors from animals treated with liposomal curcumin showed an antiangiogenic effect, including attenuation of CD31 (an endothelial marker), vascular endothelial growth factor, and interleukin-8 expression by immunohistochemistry.	Curcumin	43-51	vascular endothelial growth factor A	Homo sapiens	140-174
17372023-8	2007	NF-kappaB inhibitors, pyrrolidine dithiocarbamate and curcumin, prevented the IL-1beta-induced increase in Caco-2 TJ permeability.	Curcumin	54-62	nuclear factor kappa B subunit 1	Homo sapiens	0-9
17372023-8	2007	NF-kappaB inhibitors, pyrrolidine dithiocarbamate and curcumin, prevented the IL-1beta-induced increase in Caco-2 TJ permeability.	Curcumin	54-62	interleukin 1 beta	Homo sapiens	78-86
17431105-9	2007	Tumors from animals treated with liposomal curcumin showed an antiangiogenic effect, including attenuation of CD31 (an endothelial marker), vascular endothelial growth factor, and interleukin-8 expression by immunohistochemistry.	Curcumin	43-51	C-X-C motif chemokine ligand 8	Homo sapiens	180-193
17633203-6	2007	Curcumin exposure caused a significant increase in cellular GSH content rapidly as early as 3 h. Moreover, curcumin triggered the accumulation of Nrf2 in nucleus, and increased Nrf2 content in ARE complexes.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	146-150
17077187-6	2007	Curcumin and resveratrol showed a strong effect on BCRP induction in MCF-7 wild-type cells but no response in AhR-deficient MCF-7AHR(200) cells, supporting our hypothesis that BCRP is regulated via AhR-dependent signaling pathways.	Curcumin	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	51-55
17077187-6	2007	Curcumin and resveratrol showed a strong effect on BCRP induction in MCF-7 wild-type cells but no response in AhR-deficient MCF-7AHR(200) cells, supporting our hypothesis that BCRP is regulated via AhR-dependent signaling pathways.	Curcumin	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	176-180
17633203-6	2007	Curcumin exposure caused a significant increase in cellular GSH content rapidly as early as 3 h. Moreover, curcumin triggered the accumulation of Nrf2 in nucleus, and increased Nrf2 content in ARE complexes.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	177-181
17633203-6	2007	Curcumin exposure caused a significant increase in cellular GSH content rapidly as early as 3 h. Moreover, curcumin triggered the accumulation of Nrf2 in nucleus, and increased Nrf2 content in ARE complexes.	Curcumin	107-115	NFE2 like bZIP transcription factor 2	Homo sapiens	177-181
17633203-7	2007	These results demonstrated that induction of GST and NQO activity by curcumin may be mediated by translocation of transcription factor Nrf2 from cytoplasm to nuclear and increased binding activity of Nrf2-ARE complexes.	Curcumin	69-77	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
17633203-6	2007	Curcumin exposure caused a significant increase in cellular GSH content rapidly as early as 3 h. Moreover, curcumin triggered the accumulation of Nrf2 in nucleus, and increased Nrf2 content in ARE complexes.	Curcumin	107-115	NFE2 like bZIP transcription factor 2	Homo sapiens	146-150
17633203-7	2007	These results demonstrated that induction of GST and NQO activity by curcumin may be mediated by translocation of transcription factor Nrf2 from cytoplasm to nuclear and increased binding activity of Nrf2-ARE complexes.	Curcumin	69-77	NFE2 like bZIP transcription factor 2	Homo sapiens	200-204
17303007-7	2007	R1881 increased the expression of NKX3.1, and the AR antagonist flutamide decreased the expression of NKX3.1 in LNCaP cells, while curcumin could inhibit androgen-AR mediated induction of NKX3.1 expression.	Curcumin	131-139	androgen receptor	Homo sapiens	163-165
17148446-9	2007	Curcumin treatment also suppresses the Bcl-xL level, leading to reduced mitochondrial membrane potential and increased cleavage of procaspases and poly(ADP-ribose) polymerase.	Curcumin	0-8	BCL2 like 1	Homo sapiens	39-45
17148446-9	2007	Curcumin treatment also suppresses the Bcl-xL level, leading to reduced mitochondrial membrane potential and increased cleavage of procaspases and poly(ADP-ribose) polymerase.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	147-174
17303007-8	2007	Curcumin decreased the expression of AR and the binding activity to ARE directly.	Curcumin	0-8	androgen receptor	Homo sapiens	37-39
17303007-4	2007	Curcumin-treated cells disposed to a designated amount of androgen analog R1881 and the androgen receptor (AR) antagonist flutamide, then the expression of NKX3.1 or the activity of the NKX3.1 promoter were investigated by Western blotting or reporter gene assay, respectively.	Curcumin	0-8	androgen receptor	Homo sapiens	88-105
17303007-4	2007	Curcumin-treated cells disposed to a designated amount of androgen analog R1881 and the androgen receptor (AR) antagonist flutamide, then the expression of NKX3.1 or the activity of the NKX3.1 promoter were investigated by Western blotting or reporter gene assay, respectively.	Curcumin	0-8	androgen receptor	Homo sapiens	107-109
17332326-4	2007	In a human prostate cancer cell lines PC3 (p53(null)), curcumin reduced MDM2 protein and mRNA in a dose- and time-dependent manner, and enhanced the expression of the tumor suppressor p21(Waf1/CIP1).	Curcumin	55-63	tumor protein p53	Homo sapiens	43-46
17303007-5	2007	Finally, Western blotting and electrophoretic mobility shift assay were performed to demonstrate the effect of curcumin on the expression of AR and its binding activity to the androgen response element (ARE).	Curcumin	111-119	androgen receptor	Homo sapiens	141-143
17158602-9	2007	The results showed that LY294002 and curcumin blocked Akt translocation into nucleus.	Curcumin	37-45	AKT serine/threonine kinase 1	Homo sapiens	54-57
17332326-4	2007	In a human prostate cancer cell lines PC3 (p53(null)), curcumin reduced MDM2 protein and mRNA in a dose- and time-dependent manner, and enhanced the expression of the tumor suppressor p21(Waf1/CIP1).	Curcumin	55-63	cyclin dependent kinase inhibitor 1A	Homo sapiens	184-197
17332326-0	2007	Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	152-156
17133355-6	2007	In contrast, extracellular signal-regulated kinase, p38 MAP kinase, and c-Jun N-terminal kinase were activated after stimulation with TNF-alpha, and inhibition of each kinase by PD098059, SB203580, curcumin, or SP600125 substantially attenuated the TNF-alpha-induced c-IAP1 and c-IAP2 expression.	Curcumin	198-206	mitogen-activated protein kinase 14	Homo sapiens	52-66
17273796-0	2007	Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	38-46
17273796-0	2007	Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets.	Curcumin	0-8	interleukin 6	Homo sapiens	48-52
17273796-0	2007	Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	58-67
17273796-0	2007	Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	91-100
17273796-4	2007	However, it was unknown whether curcumin, showing inhibitory effects on NF-kappaB and MAPKs, attenuates the expression of TNF-alpha-induced IL-1beta, IL-6, IL-8, and TNF-alpha as well as cyclin E expression in HaCaT cells.	Curcumin	32-40	tumor necrosis factor	Homo sapiens	122-131
17273796-4	2007	However, it was unknown whether curcumin, showing inhibitory effects on NF-kappaB and MAPKs, attenuates the expression of TNF-alpha-induced IL-1beta, IL-6, IL-8, and TNF-alpha as well as cyclin E expression in HaCaT cells.	Curcumin	32-40	interleukin 1 beta	Homo sapiens	140-148
17273796-4	2007	However, it was unknown whether curcumin, showing inhibitory effects on NF-kappaB and MAPKs, attenuates the expression of TNF-alpha-induced IL-1beta, IL-6, IL-8, and TNF-alpha as well as cyclin E expression in HaCaT cells.	Curcumin	32-40	interleukin 6	Homo sapiens	150-154
17273796-4	2007	However, it was unknown whether curcumin, showing inhibitory effects on NF-kappaB and MAPKs, attenuates the expression of TNF-alpha-induced IL-1beta, IL-6, IL-8, and TNF-alpha as well as cyclin E expression in HaCaT cells.	Curcumin	32-40	tumor necrosis factor	Homo sapiens	166-175
17273796-5	2007	In this study, we investigated the inhibitory effect of curcumin on expression of proinflammatory cytokines and cyclin E in TNF-alpha-treated HaCaT cells.	Curcumin	56-64	tumor necrosis factor	Homo sapiens	124-133
17273796-6	2007	We found that curcumin inhibited the expression of TNF-alpha-induced IL-1beta, IL-6, and TNF-alpha, but not IL-8, in TNF-alpha-treated HaCaT cells as well as the TNF-alpha-induced cyclin E expression.	Curcumin	14-22	tumor necrosis factor	Homo sapiens	51-60
17273796-6	2007	We found that curcumin inhibited the expression of TNF-alpha-induced IL-1beta, IL-6, and TNF-alpha, but not IL-8, in TNF-alpha-treated HaCaT cells as well as the TNF-alpha-induced cyclin E expression.	Curcumin	14-22	interleukin 1 beta	Homo sapiens	69-77
17273796-6	2007	We found that curcumin inhibited the expression of TNF-alpha-induced IL-1beta, IL-6, and TNF-alpha, but not IL-8, in TNF-alpha-treated HaCaT cells as well as the TNF-alpha-induced cyclin E expression.	Curcumin	14-22	interleukin 6	Homo sapiens	79-83
17273796-6	2007	We found that curcumin inhibited the expression of TNF-alpha-induced IL-1beta, IL-6, and TNF-alpha, but not IL-8, in TNF-alpha-treated HaCaT cells as well as the TNF-alpha-induced cyclin E expression.	Curcumin	14-22	tumor necrosis factor	Homo sapiens	89-98
17273796-6	2007	We found that curcumin inhibited the expression of TNF-alpha-induced IL-1beta, IL-6, and TNF-alpha, but not IL-8, in TNF-alpha-treated HaCaT cells as well as the TNF-alpha-induced cyclin E expression.	Curcumin	14-22	tumor necrosis factor	Homo sapiens	89-98
17273796-6	2007	We found that curcumin inhibited the expression of TNF-alpha-induced IL-1beta, IL-6, and TNF-alpha, but not IL-8, in TNF-alpha-treated HaCaT cells as well as the TNF-alpha-induced cyclin E expression.	Curcumin	14-22	tumor necrosis factor	Homo sapiens	89-98
17273796-7	2007	In addition, curcumin inhibited the activation of MAPKs (JNK, p38 MAPK, and ERK) and NF-kappaB in TNF-alpha-treated HaCaT cells.	Curcumin	13-21	mitogen-activated protein kinase 8	Homo sapiens	57-60
17273796-7	2007	In addition, curcumin inhibited the activation of MAPKs (JNK, p38 MAPK, and ERK) and NF-kappaB in TNF-alpha-treated HaCaT cells.	Curcumin	13-21	mitogen-activated protein kinase 14	Homo sapiens	62-65
17273796-7	2007	In addition, curcumin inhibited the activation of MAPKs (JNK, p38 MAPK, and ERK) and NF-kappaB in TNF-alpha-treated HaCaT cells.	Curcumin	13-21	mitogen-activated protein kinase 1	Homo sapiens	50-54
17131360-5	2007	In the present study, we tested the effect of curcumin--a non-toxic anti-inflammatory reagent that inhibits p38 and NF-kappaB--on lipopolysaccharide (LPS)-induced muscle wasting in mice.	Curcumin	46-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	116-125
17133355-6	2007	In contrast, extracellular signal-regulated kinase, p38 MAP kinase, and c-Jun N-terminal kinase were activated after stimulation with TNF-alpha, and inhibition of each kinase by PD098059, SB203580, curcumin, or SP600125 substantially attenuated the TNF-alpha-induced c-IAP1 and c-IAP2 expression.	Curcumin	198-206	tumor necrosis factor	Homo sapiens	134-143
17363495-0	2007	Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells.	Curcumin	0-8	interferon alpha 1	Homo sapiens	186-195
17273796-7	2007	In addition, curcumin inhibited the activation of MAPKs (JNK, p38 MAPK, and ERK) and NF-kappaB in TNF-alpha-treated HaCaT cells.	Curcumin	13-21	mitogen-activated protein kinase 1	Homo sapiens	76-79
17273796-7	2007	In addition, curcumin inhibited the activation of MAPKs (JNK, p38 MAPK, and ERK) and NF-kappaB in TNF-alpha-treated HaCaT cells.	Curcumin	13-21	tumor necrosis factor	Homo sapiens	98-107
17273796-8	2007	Taken together, curcumin exerts anti-inflammatory and growth inhibitory effects in TNF-alpha-treated HaCaT cells through inhibition of NF-kappaB and MAPK pathways.	Curcumin	16-24	tumor necrosis factor	Homo sapiens	83-92
17273796-8	2007	Taken together, curcumin exerts anti-inflammatory and growth inhibitory effects in TNF-alpha-treated HaCaT cells through inhibition of NF-kappaB and MAPK pathways.	Curcumin	16-24	mitogen-activated protein kinase 1	Homo sapiens	149-153
17096185-2	2007	The results clearly show that curcumin induces apoptosis in these cells as evidenced by the release of cytochrome c from mitochondria to the cytosol and increase in the DNA content in sub G1 region as observed in FACS analysis.	Curcumin	30-38	cytochrome c, somatic	Homo sapiens	103-115
17363495-9	2007	Both gemcitabine and TNF activated NF-kappaB in bladder cancer cells and curcumin suppressed this activation.	Curcumin	73-81	tumor necrosis factor	Homo sapiens	21-24
17363495-11	2007	Cigarette smoke-induced expression of the NF-kappaB-regulated gene products cyclooxygenase-2 and vascular endothelial growth factor, linked with proliferation and angiogenesis, respectively, was also down-regulated by curcumin.	Curcumin	218-226	prostaglandin-endoperoxide synthase 2	Homo sapiens	76-92
17363495-11	2007	Cigarette smoke-induced expression of the NF-kappaB-regulated gene products cyclooxygenase-2 and vascular endothelial growth factor, linked with proliferation and angiogenesis, respectively, was also down-regulated by curcumin.	Curcumin	218-226	vascular endothelial growth factor A	Homo sapiens	97-131
17363495-0	2007	Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells.	Curcumin	0-8	interferon alpha 1	Homo sapiens	210-219
17363495-5	2007	We found that curcumin inhibited the proliferation, induced cell cycle arrest, and DNA fragmentation in both IFN-alpha-sensitive (RT4V6) and IFN-alpha-resistant (KU-7) bladder cancer cells.	Curcumin	14-22	interferon alpha 1	Homo sapiens	109-118
17363495-5	2007	We found that curcumin inhibited the proliferation, induced cell cycle arrest, and DNA fragmentation in both IFN-alpha-sensitive (RT4V6) and IFN-alpha-resistant (KU-7) bladder cancer cells.	Curcumin	14-22	interferon alpha 1	Homo sapiens	141-150
17363495-6	2007	Curcumin also potentiated the apoptotic effects of the chemotherapeutic agents (gemcitabine and paclitaxel) and of cytokines [tumor necrosis factor (TNF) and TNF-related apoptosis-inducing ligand].	Curcumin	0-8	tumor necrosis factor	Homo sapiens	126-147
17363495-6	2007	Curcumin also potentiated the apoptotic effects of the chemotherapeutic agents (gemcitabine and paclitaxel) and of cytokines [tumor necrosis factor (TNF) and TNF-related apoptosis-inducing ligand].	Curcumin	0-8	tumor necrosis factor	Homo sapiens	149-152
17363495-6	2007	Curcumin also potentiated the apoptotic effects of the chemotherapeutic agents (gemcitabine and paclitaxel) and of cytokines [tumor necrosis factor (TNF) and TNF-related apoptosis-inducing ligand].	Curcumin	0-8	tumor necrosis factor	Homo sapiens	158-161
17273730-6	2007	Furthermore, combination of UVB irradiation with curcumin synergistically induces apoptotic cell death in HaCaT cells through activation of caspase-8, and -3 as well as caspase-9 activation followed by release of cytochrome c.	Curcumin	49-57	cytochrome c, somatic	Homo sapiens	213-225
17572999-13	2007	(4) The concentration of TGF-beta(1) in BALF in the curcumin group and the bleomycin group were (20 +/- 3) ng/L, (39 +/- 7) ng/L at day 21, and (24 +/- 4) ng/L, (40 +/- 7) ng/L at day 28, all being statistically different between the two groups (q = 5.30, 6.27, all P &lt; 0.05).	Curcumin	52-60	transforming growth factor, beta 1	Rattus norvegicus	25-36
17572999-14	2007	(5) The expression of TGF-beta(1) mRNA in lung tissues in the curcumin group and the bleomycin group were 0.51 +/- 0.11, 0.59 +/- 0.13 at day 21, and 0.50 +/- 0.07, 0.64 +/- 0.11 at day 28, all being not statistically different between the two groups (q = 1.55, 3.13, all P &gt; 0.05).	Curcumin	62-70	transforming growth factor, beta 1	Rattus norvegicus	22-33
17572999-17	2007	CONCLUSIONS: Curcumin can alleviate alveolitis and pulmonary fibrosis induced by bleomycin in rats, possibly through its inhibition of TGF-beta(1).	Curcumin	13-21	transforming growth factor, beta 1	Rattus norvegicus	135-146
17196622-11	2007	Among the active spice-derived components studied, allyl isothiocyanate, zingerone, and curcumin significantly inhibited the cellular production of proinflammatory mediators such as TNF-alpha and nitric oxide, and significantly inhibited the release of MCP-1 from 3T3-L1 adipocytes.	Curcumin	88-96	tumor necrosis factor	Mus musculus	182-191
17198682-3	2007	In HL-60 cells, curcumin induced apoptosis and endoplasmic reticulum (ER) stress as evidenced by the survival molecules such as phosphorylated protein kinase-like ER-resident kinase, phosphorylated eukaryotic initiation factor-2alpha, glucose-regulated protein-78, and the apoptotic molecules such as caspase-4 and CAAT/enhancer binding protein homologous protein (CHOP).	Curcumin	16-24	caspase 4	Homo sapiens	301-310
17198682-3	2007	In HL-60 cells, curcumin induced apoptosis and endoplasmic reticulum (ER) stress as evidenced by the survival molecules such as phosphorylated protein kinase-like ER-resident kinase, phosphorylated eukaryotic initiation factor-2alpha, glucose-regulated protein-78, and the apoptotic molecules such as caspase-4 and CAAT/enhancer binding protein homologous protein (CHOP).	Curcumin	16-24	DNA damage inducible transcript 3	Homo sapiens	365-369
17198682-4	2007	Inhibition of caspase-4 activity by z-LEVD-FMK, blockage of CHOP expression by small interfering RNA, and treatment with salubrinal, an ER inhibitor, significantly reduced curcumin-induced apoptosis.	Curcumin	172-180	caspase 4	Homo sapiens	14-23
17198682-4	2007	Inhibition of caspase-4 activity by z-LEVD-FMK, blockage of CHOP expression by small interfering RNA, and treatment with salubrinal, an ER inhibitor, significantly reduced curcumin-induced apoptosis.	Curcumin	172-180	DNA damage inducible transcript 3	Homo sapiens	60-64
17324259-6	2007	According to their expression stability, geNorm analysis revealed rankings of the 3 most stable genes (from most stable to least stable) as follows: GAPDH, B2M and SDHA in glucosamine treated samples and HPRT1, GAPDH and B2M in curcumin or diacerein treated samples.	Curcumin	228-236	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	149-154
17373747-0	2007	NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene- induced colitis through down-regulation of NFkappa-B and iNOS.	Curcumin	21-29	nitric oxide synthase 2	Rattus norvegicus	131-135
17373747-16	2007	CONCLUSION: Curcumin treatment ameliorates colonic damage in DNCB induced colitic rats, an effect associated with an improvement in intestinal oxidative stress and downregulation of colonic NFkappa-B and iNOS expression.	Curcumin	12-20	nitric oxide synthase 2	Rattus norvegicus	204-208
17218783-0	2007	Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	107-110
17112692-3	2007	Curcumin-phospholipid complex significantly protected the liver by restoring the enzyme levels of liver glutathione system and that of superoxide dismutase, catalase and thiobarbituric acid reactive substances with respect to carbon tetrachloride treated group (P &lt; 0.05 and &lt;0.01).	Curcumin	0-8	catalase	Rattus norvegicus	157-165
17218783-5	2007	Curcumin induced G(2)/M phase cell-cycle arrest in CR cells by enhancing the p53 phosphorylation and apoptosis through the activation of caspase-3 followed by PARP degradation.	Curcumin	0-8	tumor protein p53	Homo sapiens	77-80
17218783-5	2007	Curcumin induced G(2)/M phase cell-cycle arrest in CR cells by enhancing the p53 phosphorylation and apoptosis through the activation of caspase-3 followed by PARP degradation.	Curcumin	0-8	caspase 3	Homo sapiens	137-146
17218783-5	2007	Curcumin induced G(2)/M phase cell-cycle arrest in CR cells by enhancing the p53 phosphorylation and apoptosis through the activation of caspase-3 followed by PARP degradation.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	159-163
17218783-6	2007	Curcumin also inhibited the phosphorylation of Akt while the phosphorylation of p38 MAPK was enhanced.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	47-50
17046132-4	2007	Using 1-chloro-2,4 dinitrobenzene (CDNB) as a substrate, ellagic acid and curcumin were shown to inhibit GSTs A1-1, A2-2, M1-1, M2-2 and P1-1 with IC(50) values ranging from 0.04 to 5 microM whilst genistein, kaempferol and quercetin inhibited GSTs M1-1 and M2-2 only.	Curcumin	74-82	S100 calcium binding protein A10	Homo sapiens	137-141
17046132-7	2007	Ellagic acid and curcumin also showed time- and concentration-dependent inactivation of GSTs M1-1, M2-2 and P1-1 with curcumin being a more potent inactivator than ellagic acid.	Curcumin	17-25	S100 calcium binding protein A10	Homo sapiens	108-112
17046132-7	2007	Ellagic acid and curcumin also showed time- and concentration-dependent inactivation of GSTs M1-1, M2-2 and P1-1 with curcumin being a more potent inactivator than ellagic acid.	Curcumin	118-126	S100 calcium binding protein A10	Homo sapiens	108-112
17175522-7	2007	The AP-1 beta-lactamase reporter was validated with inhibitors of kinases located upstream of AP-1 and with known natural product inhibitors of AP-1 (nordihydroguaiaretic acid and curcumin).	Curcumin	180-188	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-8
17254346-10	2007	Eosinophilia in curcumin-treated mice was markedly reduced, co-stimulatory molecule expression (CD80, CD86, and OX40L) on antigen-presenting cells was decreased, and expression of MMP-9, OAT, and TSLP genes was also attenuated.	Curcumin	16-24	CD80 antigen	Mus musculus	96-100
16713233-5	2007	LXRalpha expression and accumulation of mRNA of the LXRalpha target gene ABCg1 were increased at low curcumin concentrations.	Curcumin	101-109	ATP binding cassette subfamily G member 1	Homo sapiens	73-78
17380673-10	2007	The luciferase activities of AP-1 and NF-kappaB were stimulated in LS (P &lt; 0.01), the up-regulated luciferase activities were attenuated by PDTC at 25 micromol/L (NF-kappaB inhibitor) and curcumin at 20 micromol/L (AP-1 inhibitor) (P &lt; 0.01).	Curcumin	191-199	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	38-47
17380673-10	2007	The luciferase activities of AP-1 and NF-kappaB were stimulated in LS (P &lt; 0.01), the up-regulated luciferase activities were attenuated by PDTC at 25 micromol/L (NF-kappaB inhibitor) and curcumin at 20 micromol/L (AP-1 inhibitor) (P &lt; 0.01).	Curcumin	191-199	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	166-175
16960658-0	2007	Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin.	Curcumin	175-183	ATP binding cassette subfamily B member 1	Homo sapiens	55-69
16960658-0	2007	Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin.	Curcumin	175-183	ATP binding cassette subfamily B member 1	Homo sapiens	71-76
16960658-0	2007	Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin.	Curcumin	175-183	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	112-117
16960658-0	2007	Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin.	Curcumin	175-183	ATP binding cassette subfamily B member 1	Homo sapiens	123-153
16960658-0	2007	Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin.	Curcumin	175-183	ATP binding cassette subfamily C member 1	Homo sapiens	155-160
17254346-10	2007	Eosinophilia in curcumin-treated mice was markedly reduced, co-stimulatory molecule expression (CD80, CD86, and OX40L) on antigen-presenting cells was decreased, and expression of MMP-9, OAT, and TSLP genes was also attenuated.	Curcumin	16-24	CD86 antigen	Mus musculus	102-106
16947318-5	2007	The role of PPARgamma or NF-kappaB signaling in curcumin-induced apoptosis was examined by cotreatment with a PPARgamma antagonist or EMSA of nuclear NFkappaB complexes.	Curcumin	48-56	peroxisome proliferator activated receptor gamma	Homo sapiens	12-21
17569205-7	2007	Curcumin exhibits activities similar to recently discovered tumor necrosis factor blockers (e.g., HUMIRA, REMICADE, and ENBREL), a vascular endothelial cell growth factor blocker (e.g., AVASTIN), human epidermal growth factor receptor blockers (e.g., ERBITUX, ERLOTINIB, and GEFTINIB), and a HER2 blocker (e.g., HERCEPTIN).	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	202-234
17569205-7	2007	Curcumin exhibits activities similar to recently discovered tumor necrosis factor blockers (e.g., HUMIRA, REMICADE, and ENBREL), a vascular endothelial cell growth factor blocker (e.g., AVASTIN), human epidermal growth factor receptor blockers (e.g., ERBITUX, ERLOTINIB, and GEFTINIB), and a HER2 blocker (e.g., HERCEPTIN).	Curcumin	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	292-296
17569207-5	2007	The anti-inflammatory effect of curcumin is most likely mediated through its ability to inhibit cyclooxygenase-2 (COX-2), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS).	Curcumin	32-40	nitric oxide synthase 2	Homo sapiens	179-183
17569210-4	2007	Curcumin decreased the expression of antiapoptotic members of the Bcl-2 family and elevated the expression of p53, Bax, procaspases 3, 8, and 9.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	66-71
17569210-4	2007	Curcumin decreased the expression of antiapoptotic members of the Bcl-2 family and elevated the expression of p53, Bax, procaspases 3, 8, and 9.	Curcumin	0-8	tumor protein p53	Homo sapiens	110-113
17569210-4	2007	Curcumin decreased the expression of antiapoptotic members of the Bcl-2 family and elevated the expression of p53, Bax, procaspases 3, 8, and 9.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	115-118
17569210-4	2007	Curcumin decreased the expression of antiapoptotic members of the Bcl-2 family and elevated the expression of p53, Bax, procaspases 3, 8, and 9.	Curcumin	0-8	caspase 3	Homo sapiens	120-143
17569210-5	2007	Curcumin prevents the entry of nuclear factor KB (NF-KB) into the nucleus there by decreasing the expression of cell cycle regulatory proteins and survival factors such as Bcl-2 and survivin.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	172-177
17569210-9	2007	Curcumin was found to suppress the expression of cyclooxygenase-2, vascular endothelial growth factor, and intercellular adhesion molecule- and elevated the expression of antimetastatic proteins, the tissue inhibitor of metalloproteases-2, nonmetastatic gene 23, and Ecadherin.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	49-65
17569210-9	2007	Curcumin was found to suppress the expression of cyclooxygenase-2, vascular endothelial growth factor, and intercellular adhesion molecule- and elevated the expression of antimetastatic proteins, the tissue inhibitor of metalloproteases-2, nonmetastatic gene 23, and Ecadherin.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	67-101
17569210-9	2007	Curcumin was found to suppress the expression of cyclooxygenase-2, vascular endothelial growth factor, and intercellular adhesion molecule- and elevated the expression of antimetastatic proteins, the tissue inhibitor of metalloproteases-2, nonmetastatic gene 23, and Ecadherin.	Curcumin	0-8	cadherin 1	Homo sapiens	267-276
17569211-4	2007	Curcumin"s antiangiogenic effect is also in part due to its inhibitory effect on signal transduction pathways, including those involving protein kinase C and the transcription factors NF-kappaB and AP-1.	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	198-202
17569214-1	2007	Curcumin possesses anti-inflammatory activity and is a potent inhibitor of reactive-oxygen-generating enzymes such as lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase, and inducible nitric oxide synthase (iNOS); it is an effective inducer of heme oxygenase-1.	Curcumin	0-8	nitric oxide synthase 2	Homo sapiens	183-214
17569214-1	2007	Curcumin possesses anti-inflammatory activity and is a potent inhibitor of reactive-oxygen-generating enzymes such as lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase, and inducible nitric oxide synthase (iNOS); it is an effective inducer of heme oxygenase-1.	Curcumin	0-8	nitric oxide synthase 2	Homo sapiens	216-220
17569214-3	2007	Subsequently, curcumin inhibits the activation of NF-KB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs, and iNOS.	Curcumin	14-22	AKT serine/threonine kinase 1	Homo sapiens	148-151
17569214-3	2007	Subsequently, curcumin inhibits the activation of NF-KB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs, and iNOS.	Curcumin	14-22	nitric oxide synthase 2	Homo sapiens	163-167
17569214-4	2007	It is considered that PKC, mTOR, and EGFR tyrosine kinase are the major upstream molecular targest for curcumin intervention, whereas the nuclear oncogenes such as c-jun, c-fos, c-myc, CDKs, FAS, and iNOS might act as downstream molecular targets for curcumin actions.	Curcumin	103-111	mechanistic target of rapamycin kinase	Homo sapiens	27-31
17569214-4	2007	It is considered that PKC, mTOR, and EGFR tyrosine kinase are the major upstream molecular targest for curcumin intervention, whereas the nuclear oncogenes such as c-jun, c-fos, c-myc, CDKs, FAS, and iNOS might act as downstream molecular targets for curcumin actions.	Curcumin	103-111	nitric oxide synthase 2	Homo sapiens	200-204
17569215-8	2007	Curcumin-mediated regulation of apoptosis involves caspases, Bcl2 family members, inhibitors of apoptosis proteins, and heat shock proteins.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	61-65
17569223-6	2007	Curcumin inhibits these autoimmune diseases by regulating inflammatory cytokines such as IL-1beta, IL-6, IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB signaling pathways in immune cells.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	89-97
17569223-6	2007	Curcumin inhibits these autoimmune diseases by regulating inflammatory cytokines such as IL-1beta, IL-6, IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB signaling pathways in immune cells.	Curcumin	0-8	interleukin 6	Homo sapiens	99-103
17569223-6	2007	Curcumin inhibits these autoimmune diseases by regulating inflammatory cytokines such as IL-1beta, IL-6, IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB signaling pathways in immune cells.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	112-121
17569223-6	2007	Curcumin inhibits these autoimmune diseases by regulating inflammatory cytokines such as IL-1beta, IL-6, IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB signaling pathways in immune cells.	Curcumin	0-8	interferon gamma	Homo sapiens	126-135
16947318-6	2007	We also examined whether a clinically achievable concentration of curcumin (1 microM) would augment the apoptotic effects of fludarabine, dexamethasone, vincristine or the PDE4 inhibitor rolipram.	Curcumin	66-74	phosphodiesterase 4A	Homo sapiens	172-176
16947318-10	2007	Curcumin treatment reduced basal nuclear NF-kappaB levels and 1 microM curcumin augmented both vinca alkaloid and PDE4 inhibitor-induced apoptosis in B-CLL cells.	Curcumin	71-79	phosphodiesterase 4A	Homo sapiens	114-118
16959952-8	2007	The present report demonstrates that exogenous TGF-beta1 inhibits gene expression of PPAR-gamma in activated HSC, which is eliminated by the pretreatment with curcumin likely by interrupting TGF-beta signaling.	Curcumin	159-167	transforming growth factor, beta 1	Rattus norvegicus	47-56
16959952-8	2007	The present report demonstrates that exogenous TGF-beta1 inhibits gene expression of PPAR-gamma in activated HSC, which is eliminated by the pretreatment with curcumin likely by interrupting TGF-beta signaling.	Curcumin	159-167	transforming growth factor, beta 1	Rattus norvegicus	47-55
16959952-13	2007	Taken together, these results demonstrate that the interruption of TGF-beta signaling by curcumin induces gene expression of PPAR-gamma in activated HSC in vitro.	Curcumin	89-97	transforming growth factor, beta 1	Rattus norvegicus	67-75
17210719-10	2007	Curcumin could prevent tumor-induced thymic atrophy by restoring the activity of NF-kappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	81-90
17210719-11	2007	Further investigations suggest that neutralization of tumor-induced oxidative stress and restoration of NF-kappaB activity along with the reeducation of the TNF-alpha signaling pathway can be the mechanism behind curcumin-mediated thymic protection.	Curcumin	213-221	nuclear factor kappa B subunit 1	Homo sapiens	104-113
17210719-11	2007	Further investigations suggest that neutralization of tumor-induced oxidative stress and restoration of NF-kappaB activity along with the reeducation of the TNF-alpha signaling pathway can be the mechanism behind curcumin-mediated thymic protection.	Curcumin	213-221	tumor necrosis factor	Homo sapiens	157-166
17621542-6	2007	Results showed that, in vivo, curcumin reduced the mortality rate of LPS-infused rats by decreasing the circulating TNF-alpha levels and the consumption of peripheral platelets and plasma fibrinogen.	Curcumin	30-38	tumor necrosis factor	Rattus norvegicus	116-125
17310108-6	2007	Curcumin also reduces the expression of major matrix metalloproteinases (MMPs) due to reduced NFkappa B activity and transcriptional downregulation of AP-1.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	94-103
17310108-9	2007	68% of Curcumin treated but only 17% of untreated animals showed no or very few lung metastases, most likely as a consequence of down-regulation of NFkappa B/AP-1 dependent MMP expression and direct apoptotic effects on circulating tumor cells but not on established metastases.	Curcumin	7-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	148-157
17050652-0	2007	Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in rats.	Curcumin	10-18	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	57-62
17050652-1	2007	The aim of this study was to evaluate whether curcumin could modulate P-glycoprotein (P-gp) and CYP3A expression, and in turn modify the pharmacokinetic profiles of P-gp and CYP3A substrates in male Sprague-Dawley rats.	Curcumin	46-54	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	96-101
17050652-1	2007	The aim of this study was to evaluate whether curcumin could modulate P-glycoprotein (P-gp) and CYP3A expression, and in turn modify the pharmacokinetic profiles of P-gp and CYP3A substrates in male Sprague-Dawley rats.	Curcumin	46-54	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	174-179
17050652-4	2007	Curcumin also attenuated the CYP3A level in the small intestine but induced CYP3A expression in the liver and kidney.	Curcumin	0-8	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	29-34
17050652-4	2007	Curcumin also attenuated the CYP3A level in the small intestine but induced CYP3A expression in the liver and kidney.	Curcumin	0-8	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	76-81
17050652-6	2007	Similarly, rats treated with curcumin for 4 consecutive days showed higher AUC (AUC(0-4) and total AUC) and lower CL(oral) for peroral midazolam (a CYP3A substrate that does not interact with the P-gp) at 20 mg/kg in comparison with vehicle-treated rats.	Curcumin	29-37	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	148-153
17050652-8	2007	Analysis of the data suggests that the changes in the pharmacokinetic profiles of peroral celiprolol and midazolam in the rat model were contributed mainly by the curcumin-mediated down-regulation of intestinal P-gp and CYP3A protein levels, respectively.	Curcumin	163-171	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	220-225
17198877-6	2007	RESULTS: Comprehensive transcriptional response is associated with curcumin treatment in HF4.9 cells, including differential expression of genes encoding apoptotic signaling proteins, tumor and metastasis suppressors, transcription and splicing factors, proteins involved in regulation of cell adhesion, migration (e.g., CXCR4), lymphoid development, or B-cell activation (e.g. CD20), and others.	Curcumin	67-75	keratin 20	Homo sapiens	378-382
17198877-11	2007	Other curcumin-regulated genes identified herein, e.g., CD20, are also seemingly pertinent to the pathophysiology of follicular lymphoma.	Curcumin	6-14	keratin 20	Homo sapiens	56-60
17143561-0	2007	Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	81-84
17143561-8	2007	Nrf2 was induced by curcumin treatment, which was also partly ROS dependent.	Curcumin	20-28	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
17143561-13	2007	In conclusion, curcumin treatment results in ROS generation, activation of Nrf2 and MAP kinases and the inhibition of phosphatase activity in hepatocytes, and when curcumin is not administered in toxic doses, these multiple pathways converge to induce HO-1.	Curcumin	15-23	NFE2 like bZIP transcription factor 2	Homo sapiens	75-79
17710245-0	2007	Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) blocks the chemotaxis of neutrophils by inhibiting signal transduction through IL-8 receptors.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
17182546-4	2007	We also demonstrate that curcumin-mediated growth inhibition of B lymphoma is through inhibition of the survival kinase Akt and its key target Bad.	Curcumin	25-33	thymoma viral proto-oncogene 1	Mus musculus	120-123
17182546-7	2007	Syk is constitutively activated in primary tumors and B lymphoma cell lines and curcumin down-modulates Syk activity accompanied by down-regulation of Akt activation.	Curcumin	80-88	thymoma viral proto-oncogene 1	Mus musculus	151-154
17182546-8	2007	Moreover, we show that overexpression of Akt, a target of Syk, or Bcl-x(L), a target of Akt can overcome curcumin-induced apoptosis of B lymphoma cells.	Curcumin	105-113	thymoma viral proto-oncogene 1	Mus musculus	41-44
17182546-8	2007	Moreover, we show that overexpression of Akt, a target of Syk, or Bcl-x(L), a target of Akt can overcome curcumin-induced apoptosis of B lymphoma cells.	Curcumin	105-113	thymoma viral proto-oncogene 1	Mus musculus	88-91
17438848-6	2007	The percentage of cells of active AP-1, IL-5 protein in supernatants of allergic rhinitis T lymphocytes stimulated with PMA and curcumin were significantly lower than those of allergic rhinitis T lymphocytes stimulated with PMA (P &lt; 0.01); but significantly higher than those of allergic rhinitis T lymphocytes stimulated without PMA and those of deflection of nasal septum T lymphocytes stimulated.	Curcumin	128-136	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-38
17710245-2	2007	Chemotactic activity via human recombinant IL-8 (hrIL-8) was significantly inhibited by curcumin.	Curcumin	88-96	C-X-C motif chemokine ligand 8	Homo sapiens	43-47
17710245-3	2007	Curcumin reduced calcium ion flow induced by internalization of the IL-8 receptor.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
17710245-4	2007	We analyzed flow cytometry to evaluate the status of the IL-8 receptor after curcumin treatment.	Curcumin	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
17710245-7	2007	Following curcumin treatment, immunoprecipitation studies showed that the IL-8 receptor was associated with larger amounts of active Rab11 than that in control cells.	Curcumin	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
17710245-9	2007	The mechanism for antiinflammatory response by curcumin may involve unique regulation of the Rab11 trafficking molecule in recycling of IL-8 receptors.	Curcumin	47-55	C-X-C motif chemokine ligand 8	Homo sapiens	136-140
17190766-14	2007	CONCLUSIONS: Our study suggests that during initiation, AOM inhibits colonic COX-1 expression without affecting COX-2 and dietary curcumin may increase COX-2 expression to compensate AOM-induced reduction of COX-1 expression.	Curcumin	130-138	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	208-213
16959222-3	2006	In our hands, curcumin treatment induced a decrease of nuclear STAT3, -5a and -5b, without affecting neither STAT1, nor the phosphorylation state of STAT1, -3 or -5 in the K562 cell line.	Curcumin	14-22	signal transducer and activator of transcription 3	Homo sapiens	63-81
17374178-10	2007	Inhibition of ERKs activation by AG126, AP-1 by curcumin, and JNKs by SP600125 could reduced the induction of cyclin D1 and CDK4, whereas inhibition of p38K by SB203580 did not show any inhibitory effects on S-HELF.	Curcumin	48-56	mitogen-activated protein kinase 3	Homo sapiens	14-18
17118359-3	2006	Curcumin inhibited PKC activity, and subsequent phosphorylation of NR1 of the NMDA receptor.	Curcumin	0-8	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	67-70
17118359-6	2006	Both curcumin and TA inhibited glutamate-induced caspase-3 activation.	Curcumin	5-13	caspase 3	Homo sapiens	49-58
17341611-5	2006	Besides small peptides and oligonucleotides, numerous small molecules have been identified as blockers of STAT3 activation, including synthetic molecules (e.g., AG 490, decoy peptides, and oligonucleotides) and plant polyphenols (e.g., curcumin, resveratrol, flavopiridol, indirubin, magnolol, piceatannol, parthenolide, EGCG, and cucurbitacin).	Curcumin	236-244	signal transducer and activator of transcription 3	Homo sapiens	106-111
17261774-13	2006	However, since release of IL-6 is frequent in HCC, especially in its more advanced stages, the use of agents like curcumin or DHMEQ might be beneficial to counteract its adverse systemic effects (e.g., cachexia).	Curcumin	114-122	interleukin 6	Homo sapiens	26-30
16843665-0	2006	Novel curcumin analogs targeting TNF-induced NF-kappaB activation and proliferation in human leukemic KBM-5 cells.	Curcumin	6-14	tumor necrosis factor	Homo sapiens	33-36
17201156-0	2006	Curcumin-induced cell cycle arrest and apoptosis in human acute promyelocytic leukemia HL-60 cells via MMP changes and caspase-3 activation.	Curcumin	0-8	caspase 3	Homo sapiens	119-128
17201156-3	2006	Curcumin has been shown to inhibit cell proliferation, cell cycle arrest, cyclooxygenase (COX)-1 and -2 expression and apoptosis in several human cancer cell lines.	Curcumin	0-8	prostaglandin-endoperoxide synthase 1	Homo sapiens	74-103
17201156-7	2006	The results from flow cytometry assay indicated that curcumin induced ROS and Ca+2 productions, decreased the levels of MMP and increased the activity of caspase-3, leading to cell apoptosis.	Curcumin	53-61	caspase 3	Homo sapiens	154-163
17201156-8	2006	Western blot assay also revealed that curcumin increased the levels of Bax and the release of cytochrome c, and decreased the levels of Bcl-2 in the examined cells.	Curcumin	38-46	BCL2 associated X, apoptosis regulator	Homo sapiens	71-74
17201156-8	2006	Western blot assay also revealed that curcumin increased the levels of Bax and the release of cytochrome c, and decreased the levels of Bcl-2 in the examined cells.	Curcumin	38-46	cytochrome c, somatic	Homo sapiens	94-106
17201156-8	2006	Western blot assay also revealed that curcumin increased the levels of Bax and the release of cytochrome c, and decreased the levels of Bcl-2 in the examined cells.	Curcumin	38-46	BCL2 apoptosis regulator	Homo sapiens	136-141
17201156-9	2006	The inhibition of caspase-3 activation by z-VAD-fmk (broad-spectrum caspase inhibitor) completely blocked curcumin-induced apoptosis in HL-60 cells.	Curcumin	106-114	caspase 3	Homo sapiens	18-27
17201158-0	2006	Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3.	Curcumin	0-8	caspase 3	Homo sapiens	122-131
17201158-2	2006	Curcumin-induced apoptosis mainly involves the activation of caspase-3 and mitochondria-mediated pathway in various cancer cells of different tissue origin.	Curcumin	0-8	caspase 3	Homo sapiens	61-70
17201158-5	2006	Curcumin induced the production of reactive oxygen species (ROS) and Ca+2, decreased the levels of mitochondria membrane potential and induced caspase-3 activity.	Curcumin	0-8	caspase 3	Homo sapiens	143-152
17201158-6	2006	Curcumin also promoted the expression of Bax, cytochrome C, p53 and p21 but inhibited the expression of Bcl-2.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	41-44
17201158-6	2006	Curcumin also promoted the expression of Bax, cytochrome C, p53 and p21 but inhibited the expression of Bcl-2.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	46-58
17201158-6	2006	Curcumin also promoted the expression of Bax, cytochrome C, p53 and p21 but inhibited the expression of Bcl-2.	Curcumin	0-8	tumor protein p53	Homo sapiens	60-63
17201158-6	2006	Curcumin also promoted the expression of Bax, cytochrome C, p53 and p21 but inhibited the expression of Bcl-2.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	104-109
17201164-0	2006	Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity.	Curcumin	66-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	134-139
17201164-0	2006	Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity.	Curcumin	66-74	epidermal growth factor receptor	Homo sapiens	144-148
17201164-0	2006	Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity.	Curcumin	66-74	mitogen-activated protein kinase 3	Homo sapiens	167-173
17201164-1	2006	BACKGROUND: Several studies suggested that curcumin inhibits growth of malignant cells via inhibition of cyclooxygenase-2 (COX-2) activity.	Curcumin	43-51	prostaglandin-endoperoxide synthase 2	Homo sapiens	105-121
17201164-1	2006	BACKGROUND: Several studies suggested that curcumin inhibits growth of malignant cells via inhibition of cyclooxygenase-2 (COX-2) activity.	Curcumin	43-51	prostaglandin-endoperoxide synthase 2	Homo sapiens	123-128
17201164-2	2006	Other studies indicated that epidermal growth factor receptor (EGFR) is also inhibited by curcumin in vitro and in vivo.	Curcumin	90-98	epidermal growth factor receptor	Homo sapiens	29-61
17201164-2	2006	Other studies indicated that epidermal growth factor receptor (EGFR) is also inhibited by curcumin in vitro and in vivo.	Curcumin	90-98	epidermal growth factor receptor	Homo sapiens	63-67
17201164-4	2006	Our aim was to evaluate whether the curcumin inhibitory effect on the survival of cancer cells is associated with simultaneous down-regulation of COX-2 and EGFR and inhibition of Erk1/2 (extra-cellular signal regulated kinase) signaling pathway.	Curcumin	36-44	prostaglandin-endoperoxide synthase 2	Homo sapiens	146-151
17201164-4	2006	Our aim was to evaluate whether the curcumin inhibitory effect on the survival of cancer cells is associated with simultaneous down-regulation of COX-2 and EGFR and inhibition of Erk1/2 (extra-cellular signal regulated kinase) signaling pathway.	Curcumin	36-44	epidermal growth factor receptor	Homo sapiens	156-160
17201164-4	2006	Our aim was to evaluate whether the curcumin inhibitory effect on the survival of cancer cells is associated with simultaneous down-regulation of COX-2 and EGFR and inhibition of Erk1/2 (extra-cellular signal regulated kinase) signaling pathway.	Curcumin	36-44	mitogen-activated protein kinase 3	Homo sapiens	179-185
17201164-9	2006	RESULTS: Curcumin"s inhibitory effect on survival and apoptosis of lung and pancreatic adenocarcinoma cell lines was significantly higher in the COX-2-expressing cells than in the COX-2-deficient cells.	Curcumin	9-17	prostaglandin-endoperoxide synthase 2	Homo sapiens	145-150
17201164-9	2006	RESULTS: Curcumin"s inhibitory effect on survival and apoptosis of lung and pancreatic adenocarcinoma cell lines was significantly higher in the COX-2-expressing cells than in the COX-2-deficient cells.	Curcumin	9-17	prostaglandin-endoperoxide synthase 2	Homo sapiens	180-185
17201164-10	2006	In the p34 and PC-14 cells, curcumin decreased COX-2, EGFR and p-Erk1/2 expressions in a dose-dependent manner.	Curcumin	28-36	general transcription factor IIH subunit 3	Homo sapiens	7-10
17201164-10	2006	In the p34 and PC-14 cells, curcumin decreased COX-2, EGFR and p-Erk1/2 expressions in a dose-dependent manner.	Curcumin	28-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	47-52
17201164-10	2006	In the p34 and PC-14 cells, curcumin decreased COX-2, EGFR and p-Erk1/2 expressions in a dose-dependent manner.	Curcumin	28-36	epidermal growth factor receptor	Homo sapiens	54-58
17201164-10	2006	In the p34 and PC-14 cells, curcumin decreased COX-2, EGFR and p-Erk1/2 expressions in a dose-dependent manner.	Curcumin	28-36	mitogen-activated protein kinase 3	Homo sapiens	65-71
17201164-12	2006	CONCLUSION: Curcumin co-inhibited COX-2 and EGFR expression and decreased Erk1/2 activity.	Curcumin	12-20	prostaglandin-endoperoxide synthase 2	Homo sapiens	34-39
17201164-12	2006	CONCLUSION: Curcumin co-inhibited COX-2 and EGFR expression and decreased Erk1/2 activity.	Curcumin	12-20	epidermal growth factor receptor	Homo sapiens	44-48
17201164-12	2006	CONCLUSION: Curcumin co-inhibited COX-2 and EGFR expression and decreased Erk1/2 activity.	Curcumin	12-20	mitogen-activated protein kinase 3	Homo sapiens	74-80
17121181-0	2006	Inhibitory effect of curcumin on MDR1 gene expression in patient leukemic cells.	Curcumin	21-29	ATP binding cassette subfamily B member 1	Homo sapiens	33-37
17121181-5	2006	The aim of this study was to further investigate the effect of curcumin on MDR1 gene expression in patient leukemic cells.	Curcumin	63-71	ATP binding cassette subfamily B member 1	Homo sapiens	75-79
17121181-12	2006	It was found that curcumin reduced MDR1 gene expression in the cells from 33 patients (42%).	Curcumin	18-26	ATP binding cassette subfamily B member 1	Homo sapiens	35-39
17121181-13	2006	Curcumin affected the MDR1 gene expression in 5 of 11 relapsed cases (45%), 10 of 26 cases of drug maintenance (38%), 7 of 18 cases of completed treatment (39%), and 11 of 23 cases of new patients (48%).	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	22-26
17121181-15	2006	In summary, curcumin decreased MDR1 mRNA level in patient leukemic cells, especially in high level of MDR1 gene groups.	Curcumin	12-20	ATP binding cassette subfamily B member 1	Homo sapiens	31-35
17121181-15	2006	In summary, curcumin decreased MDR1 mRNA level in patient leukemic cells, especially in high level of MDR1 gene groups.	Curcumin	12-20	ATP binding cassette subfamily B member 1	Homo sapiens	102-106
16613838-0	2006	Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through CHOP-independent DR5 upregulation.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	20-75
16613838-0	2006	Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through CHOP-independent DR5 upregulation.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	77-82
16613838-0	2006	Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through CHOP-independent DR5 upregulation.	Curcumin	0-8	DNA damage inducible transcript 3	Homo sapiens	111-115
16613838-2	2006	In this study, we showed that curcumin, a plant product containing the phenolic phytochemical, is a potent enhancer of TRAIL-induced apoptosis through upregulation of DR5 expression.	Curcumin	30-38	TNF superfamily member 10	Homo sapiens	119-124
16770527-8	2006	Curcumin treatment was shown to decrease the levels of lipid peroxides (LPs), while the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), activities were significantly increased exhibiting the antioxidant properties of curcumin in accelerating wound healing.	Curcumin	0-8	catalase	Rattus norvegicus	136-139
16613838-4	2006	Curcumin also induced the expression of a potential pro-apoptotic gene, C/EBP homologous protein (CHOP), both at its mRNA and protein levels.	Curcumin	0-8	DNA damage inducible transcript 3	Homo sapiens	72-96
16613838-4	2006	Curcumin also induced the expression of a potential pro-apoptotic gene, C/EBP homologous protein (CHOP), both at its mRNA and protein levels.	Curcumin	0-8	DNA damage inducible transcript 3	Homo sapiens	98-102
16613838-6	2006	Taken together, the present study demonstrates that curcumin enhances TRAIL-induced apoptosis by CHOP-independent upregulation of DR5.	Curcumin	52-60	TNF superfamily member 10	Homo sapiens	70-75
16613838-6	2006	Taken together, the present study demonstrates that curcumin enhances TRAIL-induced apoptosis by CHOP-independent upregulation of DR5.	Curcumin	52-60	DNA damage inducible transcript 3	Homo sapiens	97-101
16932349-8	2006	Downregulation of Stat3 with small interfering RNA has no effect, whereas curcumin, an inhibitor of both Jak3 and the JNKs, almost completely blocks the VEGF production.	Curcumin	74-82	vascular endothelial growth factor A	Homo sapiens	153-157
17041101-7	2006	Analysis of the effects of the analogues on the expression of cancer-related genes usually affected by curcumin indicated that some induced the down-regulation of beta-catenin, Ki-ras, cyclin D1, c-Myc, and ErbB-2 at as low as one eighth the concentration at which curcumin normally has an effect.	Curcumin	265-273	erb-b2 receptor tyrosine kinase 2	Homo sapiens	207-213
17041101-7	2006	Analysis of the effects of the analogues on the expression of cancer-related genes usually affected by curcumin indicated that some induced the down-regulation of beta-catenin, Ki-ras, cyclin D1, c-Myc, and ErbB-2 at as low as one eighth the concentration at which curcumin normally has an effect.	Curcumin	103-111	erb-b2 receptor tyrosine kinase 2	Homo sapiens	207-213
16642480-0	2006	Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane).	Curcumin	162-170	interleukin 6	Homo sapiens	27-40
16642480-0	2006	Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane).	Curcumin	172-189	interleukin 6	Homo sapiens	27-40
16642480-4	2006	In the present report, we demonstrate that most HNSCC cell lines had constitutively active STAT3 and that curcumin (diferuloylmethane), a pharmacologically safe agent in humans, inhibited STAT3 phosphorylation in a dose- and time-dependent manner.	Curcumin	106-114	signal transducer and activator of transcription 3	Homo sapiens	188-193
17000667-0	2006	Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells.	Curcumin	0-8	neurotensin	Homo sapiens	18-29
17000667-0	2006	Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	39-52
16642480-4	2006	In the present report, we demonstrate that most HNSCC cell lines had constitutively active STAT3 and that curcumin (diferuloylmethane), a pharmacologically safe agent in humans, inhibited STAT3 phosphorylation in a dose- and time-dependent manner.	Curcumin	116-133	signal transducer and activator of transcription 3	Homo sapiens	188-193
16642480-5	2006	Nuclear translocation of STAT3 was also inhibited by curcumin.	Curcumin	53-61	signal transducer and activator of transcription 3	Homo sapiens	25-30
17000667-3	2006	The purpose of this study was to (a) determine the effect of neurotensin on cytokine/chemokine gene expression and cell migration in human cancer cells and (b) assess the effect of curcumin, a natural dietary product, on neurotensin-mediated processes.	Curcumin	181-189	neurotensin	Homo sapiens	221-232
16642480-6	2006	The inhibition of STAT3 activation by curcumin was reversible, although even 24 hr after curcumin removal, only partial reversal occurred.	Curcumin	38-46	signal transducer and activator of transcription 3	Homo sapiens	18-23
17000667-6	2006	Finally, the effect of curcumin on neurotensin-mediated HCT116 cell migration was analyzed.	Curcumin	23-31	neurotensin	Homo sapiens	35-46
17000667-9	2006	Curcumin inhibited neurotensin-mediated activator protein-1 and nuclear factor-kappaB activation and Ca2+ mobilization.	Curcumin	0-8	neurotensin	Homo sapiens	19-30
16642480-7	2006	Besides inhibiting constitutive expression, curcumin also abrogated the IL-6-induced activation of STAT3 in HNSCC cells.	Curcumin	44-52	interleukin 6	Homo sapiens	72-76
17000667-10	2006	Moreover, curcumin blocked neurotensin-stimulated IL-8 gene induction and protein secretion and, at a low concentration (i.e., 10 micromol/L), blocked neurotensin-stimulated colon cancer cell migration.	Curcumin	10-18	neurotensin	Homo sapiens	27-38
16642480-7	2006	Besides inhibiting constitutive expression, curcumin also abrogated the IL-6-induced activation of STAT3 in HNSCC cells.	Curcumin	44-52	signal transducer and activator of transcription 3	Homo sapiens	99-104
17000667-10	2006	Moreover, curcumin blocked neurotensin-stimulated IL-8 gene induction and protein secretion and, at a low concentration (i.e., 10 micromol/L), blocked neurotensin-stimulated colon cancer cell migration.	Curcumin	10-18	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
17000667-12	2006	Furthermore, a potential mechanism for the chemopreventive and chemotherapeutic effects of curcumin on colon cancers may be through the inhibition of gastrointestinal hormone (e.g., neurotensin)-induced chemokine expression and cell migration.	Curcumin	91-99	neurotensin	Homo sapiens	182-193
16642480-8	2006	When compared with AG490, a well-characterized JAK2 inhibitor, curcumin was more rapid (30 min vs. 4 hr) and more potent (25 microM vs. 100 microM) inhibitor of STAT3 phosphorylation.	Curcumin	63-71	signal transducer and activator of transcription 3	Homo sapiens	161-166
16642480-10	2006	Overall, our results demonstrated that curcumin is a potent inhibitor of constitutive and IL-6-induced STAT3 phosphorylation.	Curcumin	39-47	interleukin 6	Homo sapiens	90-94
16642480-10	2006	Overall, our results demonstrated that curcumin is a potent inhibitor of constitutive and IL-6-induced STAT3 phosphorylation.	Curcumin	39-47	signal transducer and activator of transcription 3	Homo sapiens	103-108
17005083-6	2006	Both SAB and curcumin showed insignificant effect on the ERK expression level, but they could significantly reduce the level of phosphorylated-ERK expression, showing significant difference as compared with that in the control group (P &lt; 0.01 and P &lt; 0.05 respectively).	Curcumin	13-21	Eph receptor B1	Rattus norvegicus	143-146
16805852-4	2006	Similarly, intragastric treatment with 270 mg/kg curcumin decreased esophageal and gastric CYP2B1 and CYP2E1, but not in lung, kidney or intestine.	Curcumin	49-57	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	102-108
17147887-1	2006	OBJECTIVE: To investigate the curcumin-induced the expression of IkappaBalpha in androgen-dependent (LNCaP) and androgen-independent (PC3) prostate cancer cells, and to study the mechanisms of curcumin on the proliferative inhibition of prostate cancer cells.	Curcumin	30-38	NFKB inhibitor alpha	Homo sapiens	65-77
17147887-7	2006	However, the expression of IkappaBalpha in PC3 cells increased gradually with the inducement of concentration-increased curcumin (F = 31.618, P &lt; 0.05).	Curcumin	120-128	NFKB inhibitor alpha	Homo sapiens	27-39
17147887-8	2006	CONCLUSIONS: IkappaBalpha may play a role in the curcumin inducing apoptosis of PC3 cell, while the curcumin inducing apoptosis of LNCaP cells is by antioxidation and inhibiting metabolites formation in LNCaP cells.	Curcumin	49-57	NFKB inhibitor alpha	Homo sapiens	13-25
17005083-7	2006	CONCLUSION: SAB and curcumin could significantly inhibit the proliferation, activation of HSC, and the production of type I collagen in HSC, the mechanism may be associated with their inhibition on ERK phosphorylation.	Curcumin	20-28	Eph receptor B1	Rattus norvegicus	198-201
16718687-0	2006	Progressive nuclear factor-kappaB activation resistant to inhibition by contraction and curcumin in mdx mice.	Curcumin	88-96	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	12-33
16814915-9	2006	Curcumin attenuated the gentamicin-induced reduction in the activities of CAT, GSHPx and level of GSH by 31%, 55% and 74%, respectively.	Curcumin	0-8	catalase	Rattus norvegicus	74-77
16814915-9	2006	Curcumin attenuated the gentamicin-induced reduction in the activities of CAT, GSHPx and level of GSH by 31%, 55% and 74%, respectively.	Curcumin	0-8	glutathione peroxidase 1	Rattus norvegicus	79-84
16985059-9	2006	Together, our results show that NF-kappaB inhibits TRAIL-induced apoptosis in human pancreatic cancer cells and suggest that combination therapy with TRAIL and NF-kappaB inhibitors, such as bortezomib, PS-1145, or curcumin, should be considered as a possible treatment strategy in patients with pancreatic cancer.	Curcumin	214-222	TNF superfamily member 10	Homo sapiens	51-56
16985059-9	2006	Together, our results show that NF-kappaB inhibits TRAIL-induced apoptosis in human pancreatic cancer cells and suggest that combination therapy with TRAIL and NF-kappaB inhibitors, such as bortezomib, PS-1145, or curcumin, should be considered as a possible treatment strategy in patients with pancreatic cancer.	Curcumin	214-222	TNF superfamily member 10	Homo sapiens	150-155
16718687-3	2006	In addition, we tested the hypothesis that NF-kappaB activity could be reduced in mdx skeletal muscle by dietary supplementation with curcumin (1% w/v) or by fatiguing muscle contractions.	Curcumin	134-142	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	43-52
16718687-4	2006	We found that NF-kappaB activity was elevated at 4 and 8 weeks of age but not at 10 days, and was resistant to inhibition by either fatiguing contractions or dietary curcumin.	Curcumin	166-174	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	14-23
16550606-0	2006	Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	22-51
16876793-4	2006	Curcumin induced changes of nuclear morphology, DNA fragmentation, release of cytochrome c as well as caspase activation in both differentiated and undifferentiated cells.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	78-90
17137104-5	2006	The activity of AC2 is almost doubled and of AC5 almost tripled as compared to curcumin.	Curcumin	79-87	adenylate cyclase 2	Homo sapiens	16-19
16550606-5	2006	At physiological concentrations (2.5 microM), curcumin rapidly inhibited phosphorylation of the mammalian target of rapamycin (mTOR) and its downstream effector molecules, p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), in a panel of cell lines (Rh1, Rh30, DU145, MCF-7 and Hela).	Curcumin	46-54	mechanistic target of rapamycin kinase	Homo sapiens	96-125
16550606-5	2006	At physiological concentrations (2.5 microM), curcumin rapidly inhibited phosphorylation of the mammalian target of rapamycin (mTOR) and its downstream effector molecules, p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), in a panel of cell lines (Rh1, Rh30, DU145, MCF-7 and Hela).	Curcumin	46-54	mechanistic target of rapamycin kinase	Homo sapiens	127-131
16550606-7	2006	The data suggest that curcumin may execute its anticancer activity primarily by blocking mTOR-mediated signaling pathways in the tumor cells.	Curcumin	22-30	mechanistic target of rapamycin kinase	Homo sapiens	89-93
16624471-3	2006	Here, we demonstrate that curcumin can induce apoptotic changes, including JNK activation, caspase-3 activation, and cleavage of PARP and PAK2, at treatment concentrations lower than 25 microM in human osteoblast cells.	Curcumin	26-34	mitogen-activated protein kinase 8	Homo sapiens	75-78
16879256-8	2006	The TLR2- and TLR4-mediated response to stimulation was dependent on NF-kappaB signalling, as shown by curcumin pretreatment of TECs.	Curcumin	103-111	toll-like receptor 4	Mus musculus	14-18
16879256-8	2006	The TLR2- and TLR4-mediated response to stimulation was dependent on NF-kappaB signalling, as shown by curcumin pretreatment of TECs.	Curcumin	103-111	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-78
16624471-3	2006	Here, we demonstrate that curcumin can induce apoptotic changes, including JNK activation, caspase-3 activation, and cleavage of PARP and PAK2, at treatment concentrations lower than 25 microM in human osteoblast cells.	Curcumin	26-34	caspase 3	Homo sapiens	91-100
16890604-5	2006	METHODS: Phex gene expression was evaluated in calvaria of 6-7-week-old mice administered with trinitrobenzene sulfonic acid (TNBS) with or without neutralizing anti-TNF-alpha antibody, dietary curcumin, or systemically with recombinant TNF-alpha.	Curcumin	194-202	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	9-13
16890604-9	2006	Dietary curcumin and anti-TNF-alpha antibody counteracted the detrimental effect of TNBS on Phex gene expression.	Curcumin	8-16	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	92-96
17039805-8	2006	When caspase-3 activity was detected, 80.5% cells presented proteases activities after 12 h incubation with curcumin.	Curcumin	108-116	caspase 3	Homo sapiens	5-14
16820944-11	2006	Moreover, elevated hepatic levels of TNF-alpha and IL-1beta post-CLP were decreased by curcumin pre-treatment.	Curcumin	87-95	tumor necrosis factor	Homo sapiens	37-46
16820944-11	2006	Moreover, elevated hepatic levels of TNF-alpha and IL-1beta post-CLP were decreased by curcumin pre-treatment.	Curcumin	87-95	interleukin 1 beta	Homo sapiens	51-59
16820944-15	2006	Inhibition of proinflammatory cytokines by curcumin may provide a novel approach to modulate the hepatic CYP function in sepsis.	Curcumin	43-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	105-108
16928820-0	2006	Modulation of the function of the multidrug resistance-linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin.	Curcumin	137-145	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	95-100
16928820-5	2006	Nontoxic concentration of curcumin I, II, and III sensitized the ABCG2-expressing cells to mitoxantrone, topotecan, SN-38, and doxorubicin.	Curcumin	26-34	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	65-70
16928820-7	2006	Curcumin I, II, and III stimulated (2.4- to 3.3-fold) ABCG2-mediated ATP hydrolysis and the IC(50)s were in the range of 7.5 to 18 nmol/L, suggesting a high affinity of curcuminoids for ABCG2.	Curcumin	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	54-59
16928820-7	2006	Curcumin I, II, and III stimulated (2.4- to 3.3-fold) ABCG2-mediated ATP hydrolysis and the IC(50)s were in the range of 7.5 to 18 nmol/L, suggesting a high affinity of curcuminoids for ABCG2.	Curcumin	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	186-191
16928820-10	2006	Collectively, these data show that, among curcuminoids, curcumin I is the most potent modulator of ABCG2 and thus should be considered as a treatment to increase the efficacy of conventional chemotherapeutic drugs.	Curcumin	56-66	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	99-104
17039805-9	2006	Western Blot analysis showed that cytoplasmic cytochrome C increased significantly after incubation with curcumin.	Curcumin	105-113	cytochrome c, somatic	Homo sapiens	46-58
16819191-0	2006	Curcumin decreases binding of Shiga-like toxin-1B on human intestinal epithelial cell line HT29 stimulated with TNF-alpha and IL-1beta: suppression of p38, JNK and NF-kappaB p65 as potential targets.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	112-121
16848894-12	2006	Treatment of diabetic rats with curcumin reduced eNOS and iNOS levels in association with reduced oxidative DNA and protein damage.	Curcumin	32-40	nitric oxide synthase 2	Rattus norvegicus	58-62
16848894-13	2006	Interestingly, curcumin further increased vasoconstrictor ET-1 in the heart.	Curcumin	15-23	endothelin 1	Rattus norvegicus	58-62
16848894-16	2006	Exposure to curcumin also increased ET-1 levels in the MVECs.	Curcumin	12-20	endothelin 1	Rattus norvegicus	36-40
16819191-0	2006	Curcumin decreases binding of Shiga-like toxin-1B on human intestinal epithelial cell line HT29 stimulated with TNF-alpha and IL-1beta: suppression of p38, JNK and NF-kappaB p65 as potential targets.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	126-134
16819191-0	2006	Curcumin decreases binding of Shiga-like toxin-1B on human intestinal epithelial cell line HT29 stimulated with TNF-alpha and IL-1beta: suppression of p38, JNK and NF-kappaB p65 as potential targets.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	151-154
16819191-0	2006	Curcumin decreases binding of Shiga-like toxin-1B on human intestinal epithelial cell line HT29 stimulated with TNF-alpha and IL-1beta: suppression of p38, JNK and NF-kappaB p65 as potential targets.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	156-159
16819191-0	2006	Curcumin decreases binding of Shiga-like toxin-1B on human intestinal epithelial cell line HT29 stimulated with TNF-alpha and IL-1beta: suppression of p38, JNK and NF-kappaB p65 as potential targets.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	164-173
16819191-5	2006	Curcumin significantly inhibited the binding of Stx and the production of Gb3 synthase (GalT6) mRNA in HT29 IECs stimulated with TNF-alpha and IL-1beta.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	129-138
16819191-5	2006	Curcumin significantly inhibited the binding of Stx and the production of Gb3 synthase (GalT6) mRNA in HT29 IECs stimulated with TNF-alpha and IL-1beta.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	143-151
16819191-6	2006	Additionally, curcumin was able to inhibit mitogen-activated protein kinases (MAPKs), such as p38 and JNK, but not ERK1/2, degradation of IkappaB or translocation of NF-kappaB p65.	Curcumin	14-22	mitogen-activated protein kinase 1	Homo sapiens	94-97
16819191-6	2006	Additionally, curcumin was able to inhibit mitogen-activated protein kinases (MAPKs), such as p38 and JNK, but not ERK1/2, degradation of IkappaB or translocation of NF-kappaB p65.	Curcumin	14-22	mitogen-activated protein kinase 8	Homo sapiens	102-105
16819191-6	2006	Additionally, curcumin was able to inhibit mitogen-activated protein kinases (MAPKs), such as p38 and JNK, but not ERK1/2, degradation of IkappaB or translocation of NF-kappaB p65.	Curcumin	14-22	nuclear factor kappa B subunit 1	Homo sapiens	166-175
16819191-7	2006	Furthermore, curcumin significantly attenuated Stx-1 induced cell death and IL-8 expression.	Curcumin	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	76-80
16751071-6	2006	Additionally, curcumin significantly decreased mRNA expression of early responding cytokines (IL-1 IL-6, IL-18, TNF-alpha, and lymphotoxin-beta) and the fibrogenic cytokine, TGF-beta, in cutaneous tissues at 21 days postradiation.	Curcumin	14-22	tumor necrosis factor	Mus musculus	112-121
16715036-12	2006	The results indicate that intravenous administration of curcumin before the onset of sepsis attenuated tissue injury, reduced mortality, and decreased the expression of TNF-alpha in septic animals.	Curcumin	56-64	tumor necrosis factor	Rattus norvegicus	169-178
16715036-16	2006	In cultured RAW 264.7 cells, curcumin inhibited endotoxin-induced increases in TNF-alpha expression and markedly up-regulated PPAR-gamma expression without affecting cell viability.	Curcumin	29-37	tumor necrosis factor	Mus musculus	79-88
16598677-11	2006	Pretreatment with curcumin, which has a HAT inhibitory activity specific for CBP/p300, attenuates histone modifications, IEGs expression and also the severity of status epilepticus after kainate treatment.	Curcumin	18-26	CREB binding protein	Homo sapiens	77-85
16910344-5	2006	Curcumin exhibited a synergistic effect on SOD and CAT activities in the ST and MB regions.	Curcumin	0-8	catalase	Mus musculus	51-54
16678799-7	2006	These results imply that curcumin inhibits both MyD88- and TRIF-dependent pathways in LPS-induced TLR4 signaling.	Curcumin	25-33	TIR domain containing adaptor molecule 1	Homo sapiens	59-63
16547587-0	2006	Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway.	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	90-95
16547587-5	2006	The results of present study suggested that the cytoprotective effects of curcumin might be mediated, at least in part, by the Bcl-2-mitochondria-ROS-iNOS pathway.	Curcumin	74-82	BCL2, apoptosis regulator	Rattus norvegicus	127-132
16547587-0	2006	Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway.	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	113-117
16547587-5	2006	The results of present study suggested that the cytoprotective effects of curcumin might be mediated, at least in part, by the Bcl-2-mitochondria-ROS-iNOS pathway.	Curcumin	74-82	nitric oxide synthase 2	Rattus norvegicus	150-154
16547587-3	2006	Curcumin protected PC12 cells against MPP(+)-induced cytotoxicity and apoptosis not only by inducing overexpression of Bcl-2, but also reducing the loss of mitochondrial membrane potential (MMP), an increase in intracellular reactive oxygen species (ROS) and overexpression of inducible nitric oxide synthase (iNOS).	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	119-124
16547587-3	2006	Curcumin protected PC12 cells against MPP(+)-induced cytotoxicity and apoptosis not only by inducing overexpression of Bcl-2, but also reducing the loss of mitochondrial membrane potential (MMP), an increase in intracellular reactive oxygen species (ROS) and overexpression of inducible nitric oxide synthase (iNOS).	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	277-308
16547587-3	2006	Curcumin protected PC12 cells against MPP(+)-induced cytotoxicity and apoptosis not only by inducing overexpression of Bcl-2, but also reducing the loss of mitochondrial membrane potential (MMP), an increase in intracellular reactive oxygen species (ROS) and overexpression of inducible nitric oxide synthase (iNOS).	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	310-314
16628653-0	2006	Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells.	Curcumin	27-35	notch receptor 1	Homo sapiens	0-7
16497702-2	2006	It is widely believed that curcumin pro-apoptotic properties are mediated by downregulation of NF kappa B (NFkappaB).	Curcumin	27-35	nuclear factor kappa B subunit 1	Homo sapiens	95-105
16628653-4	2006	It also has been reported that there is cross-talk between Notch-1 and another major cell growth and apoptotic regulatory pathway, the nuclear factor kappaB (NF-kappaB) pathway, which is down-regulated by both curcumin and reduction of Notch-1 levels.	Curcumin	210-218	notch receptor 1	Homo sapiens	59-66
16497702-2	2006	It is widely believed that curcumin pro-apoptotic properties are mediated by downregulation of NF kappa B (NFkappaB).	Curcumin	27-35	nuclear factor kappa B subunit 1	Homo sapiens	107-115
16497702-4	2006	We have shown previously that curcumin inhibits NFkappaB, activates JNK and promotes apoptosis in HCT116 colorectal cancer cells.	Curcumin	30-38	nuclear factor kappa B subunit 1	Homo sapiens	48-56
16497702-4	2006	We have shown previously that curcumin inhibits NFkappaB, activates JNK and promotes apoptosis in HCT116 colorectal cancer cells.	Curcumin	30-38	mitogen-activated protein kinase 8	Homo sapiens	68-71
16628653-4	2006	It also has been reported that there is cross-talk between Notch-1 and another major cell growth and apoptotic regulatory pathway, the nuclear factor kappaB (NF-kappaB) pathway, which is down-regulated by both curcumin and reduction of Notch-1 levels.	Curcumin	210-218	nuclear factor kappa B subunit 1	Homo sapiens	158-167
16497702-6	2006	Indeed, overexpression of p65 enhanced curcumin-mediated apoptosis as assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) assay and poly(ADP-ribose) polymerase (PARP) cleavage.	Curcumin	39-47	poly(ADP-ribose) polymerase 1	Homo sapiens	158-185
16497702-6	2006	Indeed, overexpression of p65 enhanced curcumin-mediated apoptosis as assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) assay and poly(ADP-ribose) polymerase (PARP) cleavage.	Curcumin	39-47	poly(ADP-ribose) polymerase 1	Homo sapiens	187-191
16497702-8	2006	Curcumin treatment inhibited expression of NFkappaB anti-apoptotic target genes in mock-transfected and in p65-overexpressing HCT116 cells, although expression levels remained higher in the latter.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	43-51
16497702-9	2006	Taken together, these results show that curcumin-mediated activation of JNK or induction of apoptosis does not require inhibition of p65.	Curcumin	40-48	mitogen-activated protein kinase 8	Homo sapiens	72-75
16628653-4	2006	It also has been reported that there is cross-talk between Notch-1 and another major cell growth and apoptotic regulatory pathway, the nuclear factor kappaB (NF-kappaB) pathway, which is down-regulated by both curcumin and reduction of Notch-1 levels.	Curcumin	210-218	notch receptor 1	Homo sapiens	236-243
16628653-5	2006	However, to the authors" knowledge to date, no studies have determined whether the down-regulation of Notch-1 signaling, resulting in the inactivation of NF-kappaB activity, contributes to curcumin-induced cell growth inhibition and apoptosis in pancreatic cancer cells.	Curcumin	189-197	notch receptor 1	Homo sapiens	102-109
16628653-8	2006	Notch-1, Hes-1, and Bcl-XL expression levels concomitantly were down-regulated by curcumin treatment.	Curcumin	82-90	notch receptor 1	Homo sapiens	0-7
16628653-8	2006	Notch-1, Hes-1, and Bcl-XL expression levels concomitantly were down-regulated by curcumin treatment.	Curcumin	82-90	BCL2 like 1	Homo sapiens	20-26
16628653-10	2006	The down-regulation of Notch-1 by small-interfering RNA prior to curcumin treatment resulted in enhanced cell growth inhibition and apoptosis.	Curcumin	65-73	notch receptor 1	Homo sapiens	23-30
16628653-11	2006	CONCLUSIONS: The current results provide the first demonstration to the authors" knowledge that the Notch-1 signaling pathway is associated mechanistically with NF-kappaB activity during curcumin-induced cell growth inhibition and apoptosis of pancreatic cells.	Curcumin	187-195	notch receptor 1	Homo sapiens	100-107
16628653-11	2006	CONCLUSIONS: The current results provide the first demonstration to the authors" knowledge that the Notch-1 signaling pathway is associated mechanistically with NF-kappaB activity during curcumin-induced cell growth inhibition and apoptosis of pancreatic cells.	Curcumin	187-195	nuclear factor kappa B subunit 1	Homo sapiens	161-170
16628653-12	2006	These results suggest that the down-regulation of Notch signaling by curcumin may be a novel strategy for the treatment of patients with pancreatic cancer.	Curcumin	69-77	notch receptor 1	Homo sapiens	50-55
19127718-1	2006	It is demonstrated by using high-level ab initio computations that the yellow curcumin pigment, bis-(4-hydroxy-3-methoxyphenyl)-1,6-diene-3,5-dione, in the east Indian root plant turmeric (Curcuma longa) exhibits unique charge and bonding characteristics that facilitate penetration into the blood-brain barrier and binding to amyloid beta (Abeta).	Curcumin	78-86	amyloid beta precursor protein	Homo sapiens	341-346
16800992-8	2006	CONCLUSION: Curcumin could significantly inhibit the growth of human ovarian cancer cells; inducing apoptosis through up-regulating Caspase-3 and down-regulating gene expression of NF-kappaB is probably one of its molecular mechanisms.	Curcumin	12-20	caspase 3	Homo sapiens	132-141
16800992-8	2006	CONCLUSION: Curcumin could significantly inhibit the growth of human ovarian cancer cells; inducing apoptosis through up-regulating Caspase-3 and down-regulating gene expression of NF-kappaB is probably one of its molecular mechanisms.	Curcumin	12-20	nuclear factor kappa B subunit 1	Homo sapiens	181-190
16685393-2	2006	The IFN-alpha-induced COX-2 expression and STAT1 activation were markedly inhibited by the addition of curcumin to the IFN-alpha-pretreated cells.	Curcumin	103-111	interferon alpha 1	Homo sapiens	4-13
16685393-2	2006	The IFN-alpha-induced COX-2 expression and STAT1 activation were markedly inhibited by the addition of curcumin to the IFN-alpha-pretreated cells.	Curcumin	103-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
16685393-2	2006	The IFN-alpha-induced COX-2 expression and STAT1 activation were markedly inhibited by the addition of curcumin to the IFN-alpha-pretreated cells.	Curcumin	103-111	interferon alpha 1	Homo sapiens	119-128
16685393-5	2006	The addition of curcumin or celecoxib to the IFN-alpha-pretreated A549 cells altered the IFN-alpha sensitivity of cell growth inhibition.	Curcumin	16-24	interferon alpha 1	Homo sapiens	45-54
16685393-5	2006	The addition of curcumin or celecoxib to the IFN-alpha-pretreated A549 cells altered the IFN-alpha sensitivity of cell growth inhibition.	Curcumin	16-24	interferon alpha 1	Homo sapiens	89-98
16685395-0	2006	Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-75
16685395-3	2006	Moreover, curcumin suppressed the transcriptional activity of HIF-1 under hypoxia, leading to a decrease in the expression of vascular endothelial growth factor (VEGF), a major HIF-1 target angiogenic factor.	Curcumin	10-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-67
16685395-3	2006	Moreover, curcumin suppressed the transcriptional activity of HIF-1 under hypoxia, leading to a decrease in the expression of vascular endothelial growth factor (VEGF), a major HIF-1 target angiogenic factor.	Curcumin	10-18	vascular endothelial growth factor A	Homo sapiens	126-160
16685395-3	2006	Moreover, curcumin suppressed the transcriptional activity of HIF-1 under hypoxia, leading to a decrease in the expression of vascular endothelial growth factor (VEGF), a major HIF-1 target angiogenic factor.	Curcumin	10-18	vascular endothelial growth factor A	Homo sapiens	162-166
16685395-3	2006	Moreover, curcumin suppressed the transcriptional activity of HIF-1 under hypoxia, leading to a decrease in the expression of vascular endothelial growth factor (VEGF), a major HIF-1 target angiogenic factor.	Curcumin	10-18	hypoxia inducible factor 1 subunit alpha	Homo sapiens	177-182
16685395-4	2006	Curcumin also blocked hypoxia-stimulated angiogenesis in vitro and down-regulated HIF-1alpha and VEGF expression in vascular endothelial cells.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-92
16685395-4	2006	Curcumin also blocked hypoxia-stimulated angiogenesis in vitro and down-regulated HIF-1alpha and VEGF expression in vascular endothelial cells.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	97-101
16685395-5	2006	These findings suggest that curcumin may play pivotal roles in tumor suppression via the inhibition of HIF-1alpha-mediated angiogenesis.	Curcumin	28-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-113
19127718-6	2006	2004, 280, 5892-5901) that demonstrates curcumin pigment"s binding ability to Abeta both in vivo and in vitro, it is shown here that curcumin possesses suitable charge and bonding features to facilitate the binding to Abeta.	Curcumin	40-48	amyloid beta precursor protein	Homo sapiens	78-83
19127718-6	2006	2004, 280, 5892-5901) that demonstrates curcumin pigment"s binding ability to Abeta both in vivo and in vitro, it is shown here that curcumin possesses suitable charge and bonding features to facilitate the binding to Abeta.	Curcumin	40-48	amyloid beta precursor protein	Homo sapiens	218-223
19127718-6	2006	2004, 280, 5892-5901) that demonstrates curcumin pigment"s binding ability to Abeta both in vivo and in vitro, it is shown here that curcumin possesses suitable charge and bonding features to facilitate the binding to Abeta.	Curcumin	133-141	amyloid beta precursor protein	Homo sapiens	78-83
19127718-6	2006	2004, 280, 5892-5901) that demonstrates curcumin pigment"s binding ability to Abeta both in vivo and in vitro, it is shown here that curcumin possesses suitable charge and bonding features to facilitate the binding to Abeta.	Curcumin	133-141	amyloid beta precursor protein	Homo sapiens	218-223
16306131-5	2006	Curcumin induced gene expression of peroxisome proliferator-activated receptor (PPAR)-gamma and stimulated its activity in activated HSCs, which was required for curcumin to suppress ECM gene expression, including alphaI(I)-collagen.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	36-91
16563357-6	2006	For instance, the cell-signaling pathways inhibited by curcumin alone include NF-kappaB, AP-1, STAT3, Akt, Bcl-2, Bcl-X(L), caspases, PARP, IKK, EGFR, HER2, JNK, MAPK, COX2, and 5-LOX.	Curcumin	55-63	seed linoleate 9S-lipoxygenase-3	Glycine max	180-183
16687078-3	2006	This study was to investigate the effects of curcumin on the acetylation of histone H3 and the expression of p21(WAF1/CIP1) gene in human lymphoma cell line Raji.	Curcumin	45-53	cyclin dependent kinase inhibitor 1A	Homo sapiens	113-122
16687078-7	2006	RESULTS: Curcumin induced hyperacetylation of histone H3 at the site of p21(WAF1/CIP1) promoter by 1.9 folds, and enhanced the levels of p21(WAF1/CIP1) mRNA by 4.2 folds and protein by 5.1 folds 24 h after treatment.	Curcumin	9-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	72-75
16687078-7	2006	RESULTS: Curcumin induced hyperacetylation of histone H3 at the site of p21(WAF1/CIP1) promoter by 1.9 folds, and enhanced the levels of p21(WAF1/CIP1) mRNA by 4.2 folds and protein by 5.1 folds 24 h after treatment.	Curcumin	9-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	76-80
16687078-7	2006	RESULTS: Curcumin induced hyperacetylation of histone H3 at the site of p21(WAF1/CIP1) promoter by 1.9 folds, and enhanced the levels of p21(WAF1/CIP1) mRNA by 4.2 folds and protein by 5.1 folds 24 h after treatment.	Curcumin	9-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	81-85
16687078-7	2006	RESULTS: Curcumin induced hyperacetylation of histone H3 at the site of p21(WAF1/CIP1) promoter by 1.9 folds, and enhanced the levels of p21(WAF1/CIP1) mRNA by 4.2 folds and protein by 5.1 folds 24 h after treatment.	Curcumin	9-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	137-140
16687078-7	2006	RESULTS: Curcumin induced hyperacetylation of histone H3 at the site of p21(WAF1/CIP1) promoter by 1.9 folds, and enhanced the levels of p21(WAF1/CIP1) mRNA by 4.2 folds and protein by 5.1 folds 24 h after treatment.	Curcumin	9-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	76-85
16687078-8	2006	Raji cells were arrested at G(2)/M phase when treated with curcumin for 24 h, and at G(0)/G(1) phase when treated for 36 h. CONCLUSION: Curcumin, with epigenetic modificative effects, could enhance the acetylayion of histone H3 at the site of p21(WAF1/CIP1) promoter gene, improve transcription of p21(WAF1/CIP1) gene, and arrest cell cycle progression of Raji cells.	Curcumin	136-144	cyclin dependent kinase inhibitor 1A	Homo sapiens	243-246
16687078-8	2006	Raji cells were arrested at G(2)/M phase when treated with curcumin for 24 h, and at G(0)/G(1) phase when treated for 36 h. CONCLUSION: Curcumin, with epigenetic modificative effects, could enhance the acetylayion of histone H3 at the site of p21(WAF1/CIP1) promoter gene, improve transcription of p21(WAF1/CIP1) gene, and arrest cell cycle progression of Raji cells.	Curcumin	136-144	cyclin dependent kinase inhibitor 1A	Homo sapiens	247-251
16687078-8	2006	Raji cells were arrested at G(2)/M phase when treated with curcumin for 24 h, and at G(0)/G(1) phase when treated for 36 h. CONCLUSION: Curcumin, with epigenetic modificative effects, could enhance the acetylayion of histone H3 at the site of p21(WAF1/CIP1) promoter gene, improve transcription of p21(WAF1/CIP1) gene, and arrest cell cycle progression of Raji cells.	Curcumin	136-144	cyclin dependent kinase inhibitor 1A	Homo sapiens	252-256
16687078-8	2006	Raji cells were arrested at G(2)/M phase when treated with curcumin for 24 h, and at G(0)/G(1) phase when treated for 36 h. CONCLUSION: Curcumin, with epigenetic modificative effects, could enhance the acetylayion of histone H3 at the site of p21(WAF1/CIP1) promoter gene, improve transcription of p21(WAF1/CIP1) gene, and arrest cell cycle progression of Raji cells.	Curcumin	136-144	cyclin dependent kinase inhibitor 1A	Homo sapiens	298-301
16306131-5	2006	Curcumin induced gene expression of peroxisome proliferator-activated receptor (PPAR)-gamma and stimulated its activity in activated HSCs, which was required for curcumin to suppress ECM gene expression, including alphaI(I)-collagen.	Curcumin	162-170	peroxisome proliferator activated receptor gamma	Homo sapiens	36-91
16687078-8	2006	Raji cells were arrested at G(2)/M phase when treated with curcumin for 24 h, and at G(0)/G(1) phase when treated for 36 h. CONCLUSION: Curcumin, with epigenetic modificative effects, could enhance the acetylayion of histone H3 at the site of p21(WAF1/CIP1) promoter gene, improve transcription of p21(WAF1/CIP1) gene, and arrest cell cycle progression of Raji cells.	Curcumin	136-144	cyclin dependent kinase inhibitor 1A	Homo sapiens	247-256
16306131-8	2006	We hypothesize that inhibition of alphaI(I)-collagen gene expression in HSCs by curcumin is mediated by suppressing CTGF gene expression through attenuating oxidative stress and interrupting TGF-beta signaling.	Curcumin	80-88	transforming growth factor beta 1	Homo sapiens	191-199
16306131-11	2006	Activation of PPAR-gamma by curcumin resulted in the interruption of TGF-beta signaling by suppressing gene expression of TGF-beta receptors, leading to inhibition of CTGF gene expression.	Curcumin	28-36	peroxisome proliferator activated receptor gamma	Homo sapiens	14-24
16306131-11	2006	Activation of PPAR-gamma by curcumin resulted in the interruption of TGF-beta signaling by suppressing gene expression of TGF-beta receptors, leading to inhibition of CTGF gene expression.	Curcumin	28-36	transforming growth factor beta 1	Homo sapiens	69-77
16306131-11	2006	Activation of PPAR-gamma by curcumin resulted in the interruption of TGF-beta signaling by suppressing gene expression of TGF-beta receptors, leading to inhibition of CTGF gene expression.	Curcumin	28-36	transforming growth factor beta 1	Homo sapiens	122-130
16306131-13	2006	De novo synthesis of cellular GSH was a prerequisite for curcumin to interrupt TGF-beta signaling and inhibited gene expression of CTGF and alphaI(I)-collagen in activated HSCs.	Curcumin	57-65	transforming growth factor beta 1	Homo sapiens	79-87
16306131-14	2006	Taken together, our results demonstrate that inhibition of alphaI(I)-collagen gene expression by curcumin in activated HSCs results from suppression of CTGF gene expression through increasing cellular GSH contents and interruption of TGF-beta signaling.	Curcumin	97-105	transforming growth factor beta 1	Homo sapiens	234-242
16779518-7	2006	Curcumin-treated mice also exhibited relative decreases in aortic tissue activator protein-1 and nuclear factor kappaB DNA binding activities and significantly lower aortic tissue concentrations of interleukin-1beta (IL-1beta), IL-6, monocyte chemoattractant protein-1, and matrix metalloproteinase-9 (all p &lt; 0.05).	Curcumin	0-8	interleukin 1 beta	Mus musculus	198-215
16779518-7	2006	Curcumin-treated mice also exhibited relative decreases in aortic tissue activator protein-1 and nuclear factor kappaB DNA binding activities and significantly lower aortic tissue concentrations of interleukin-1beta (IL-1beta), IL-6, monocyte chemoattractant protein-1, and matrix metalloproteinase-9 (all p &lt; 0.05).	Curcumin	0-8	interleukin 1 beta	Mus musculus	217-225
16779518-7	2006	Curcumin-treated mice also exhibited relative decreases in aortic tissue activator protein-1 and nuclear factor kappaB DNA binding activities and significantly lower aortic tissue concentrations of interleukin-1beta (IL-1beta), IL-6, monocyte chemoattractant protein-1, and matrix metalloproteinase-9 (all p &lt; 0.05).	Curcumin	0-8	interleukin 6	Mus musculus	228-232
16639030-11	2006	RNA expression studies showed that curcumin had an inhibitory effect on the glucose-induced VEGF mRNA expression.	Curcumin	35-43	vascular endothelial growth factor A	Homo sapiens	92-96
16584726-3	2006	The aim of the present study was to explore the antinociceptive effect of curcumin and its effect on tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) release in streptozotocin induced diabetic mice.	Curcumin	74-82	tumor necrosis factor	Mus musculus	131-140
16584726-8	2006	Curcumin also inhibited the TNF-alpha and NO release in a dose dependent manner.	Curcumin	0-8	tumor necrosis factor	Mus musculus	28-37
16584726-9	2006	These results indicate an antinociceptive activity of curcumin possibly through its inhibitory action on NO and TNF-alpha release and point towards its potential to attenuate diabetic neuropathic pain.	Curcumin	54-62	tumor necrosis factor	Mus musculus	112-121
16639030-12	2006	In addition, VEGF-mediated, membrane-associated changes in the PKC-betaII translocation in HRECs was inhibited by 31% on treatment with 10 microM curcumin.	Curcumin	146-154	vascular endothelial growth factor A	Homo sapiens	13-17
16639030-13	2006	CONCLUSIONS: These data suggest an underlying mechanism whereby curcumin induces the apoptosis in HRECs by the regulation of intracellular ROS generation, VEGF expression and release, and VEGF-mediated PKC-betaII translocation.	Curcumin	64-72	vascular endothelial growth factor A	Homo sapiens	155-159
16639030-13	2006	CONCLUSIONS: These data suggest an underlying mechanism whereby curcumin induces the apoptosis in HRECs by the regulation of intracellular ROS generation, VEGF expression and release, and VEGF-mediated PKC-betaII translocation.	Curcumin	64-72	vascular endothelial growth factor A	Homo sapiens	188-192
16643279-5	2006	The inhibition of ER calcium pump, with thapsigargin, curcumin, 2,5-di(t-butyl)hydroquinone or cyclopiazonic acid, maintains a threshold levels of calcium that is correlated to the recovery of endogenous F508del-CFTR transport activity.	Curcumin	54-62	CF transmembrane conductance regulator	Homo sapiens	212-216
16424149-0	2006	Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network.	Curcumin	82-90	CF transmembrane conductance regulator	Homo sapiens	20-24
16424149-0	2006	Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network.	Curcumin	82-90	CF transmembrane conductance regulator	Homo sapiens	26-77
16424149-3	2006	Recently, curcumin was shown to rescue DeltaF508-CFTR localization and function.	Curcumin	10-18	CF transmembrane conductance regulator	Homo sapiens	49-53
16424149-5	2006	Here, we hypothesized that curcumin could restore a functional DeltaF508-CFTR to the plasma membrane acting via the K18 network.	Curcumin	27-35	CF transmembrane conductance regulator	Homo sapiens	73-77
16424149-6	2006	First, we analyzed the effects of curcumin on the localization of DeltaF508-CFTR in different cell lines (HeLa cells stably transfected with wild-type CFTR or DeltaF508-CFTR, CALU-3 cells, or cystic fibrosis pancreatic epithelial cells CFPAC-1) and found that it was significantly delocalized toward the plasma membrane in DeltaF508-CFTR-expressing cells.	Curcumin	34-42	CF transmembrane conductance regulator	Homo sapiens	76-80
16424149-7	2006	We also performed a functional assay for the CFTR chloride channel in CFPAC-1 cells treated or not with curcumin and detected an increase in a cAMP-dependent chloride efflux in treated DeltaF508-CFTR-expressing cells.	Curcumin	104-112	CF transmembrane conductance regulator	Homo sapiens	45-49
16424149-7	2006	We also performed a functional assay for the CFTR chloride channel in CFPAC-1 cells treated or not with curcumin and detected an increase in a cAMP-dependent chloride efflux in treated DeltaF508-CFTR-expressing cells.	Curcumin	104-112	CF transmembrane conductance regulator	Homo sapiens	195-199
16526022-0	2006	Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosis.	Curcumin	20-28	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	137-141
16526022-10	2006	Electrophoretic mobility shift assay revealed that activation of NFkappaB-induced by TNFalpha is down regulated by curcumin.	Curcumin	115-123	nuclear factor kappa B subunit 1	Homo sapiens	65-73
16526022-10	2006	Electrophoretic mobility shift assay revealed that activation of NFkappaB-induced by TNFalpha is down regulated by curcumin.	Curcumin	115-123	tumor necrosis factor	Homo sapiens	85-93
16526022-11	2006	Curcumin blocked IkBalpha phosphorylation and degradation, leading to abrogation of NFkappaB activation.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	84-92
16526022-12	2006	Curcumin also down regulated the expression of COX-2, a gene regulated by NFkappaB.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
16526022-12	2006	Curcumin also down regulated the expression of COX-2, a gene regulated by NFkappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	74-82
16526022-13	2006	Binding of AP-1, an indispensable component for efficient epithelial tissue-specific gene expression of HPV was also selectively down regulated by curcumin.	Curcumin	147-155	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	11-15
16731771-6	2006	Using a homology model of the three-dimensional structure of human P-12-LOX, we did computational docking of synthetic curcuminoids (curcumin derivatives) to identify inhibitors superior to curcumin.	Curcumin	119-127	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	67-75
16731771-6	2006	Using a homology model of the three-dimensional structure of human P-12-LOX, we did computational docking of synthetic curcuminoids (curcumin derivatives) to identify inhibitors superior to curcumin.	Curcumin	133-141	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	67-75
16731771-7	2006	Docking of the known inhibitors curcumin and NDGA to P-12-LOX was used to optimize the docking protocol for the system in study.	Curcumin	32-40	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	53-61
16596191-0	2006	Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer T24 cells.	Curcumin	72-80	prostaglandin-endoperoxide synthase 2	Homo sapiens	43-59
16596191-3	2006	Curcumin inhibited the growth of T24 cells and induced G2/M arrest in a concentration-dependent manner, effects associated with the down-regulation of cyclin A and up-regulation of cyclin-dependent kinase (Cdk) inhibitor p21 (WAF1/CIP1).	Curcumin	0-8	cyclin A2	Homo sapiens	151-159
16596191-3	2006	Curcumin inhibited the growth of T24 cells and induced G2/M arrest in a concentration-dependent manner, effects associated with the down-regulation of cyclin A and up-regulation of cyclin-dependent kinase (Cdk) inhibitor p21 (WAF1/CIP1).	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	221-224
16596191-3	2006	Curcumin inhibited the growth of T24 cells and induced G2/M arrest in a concentration-dependent manner, effects associated with the down-regulation of cyclin A and up-regulation of cyclin-dependent kinase (Cdk) inhibitor p21 (WAF1/CIP1).	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	226-235
16596191-5	2006	Furthermore, curcumin decreased the levels of COX-2 mRNA and protein expression without significant changes in the levels of COX-1, which correlated with a decrease in prostaglandin E2 (PGE2) synthesis.	Curcumin	13-21	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
16288784-0	2006	Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats.	Curcumin	24-32	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	94-109
16445949-10	2006	Induction of apoptosis by curcumin is initiated by the release of cytochrome c from mitochondria into the cytosol, and evidenced by the increase in DNA content in the sub-G1 region as obtained from FACS analysis.	Curcumin	26-34	cytochrome c, somatic	Homo sapiens	66-78
16288784-1	2006	We investigated the effects of curcumin, a major antioxidant constituent of turmeric, on hepatic cytochrome P450 (CYP) activity in rats.	Curcumin	31-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	97-112
16288784-1	2006	We investigated the effects of curcumin, a major antioxidant constituent of turmeric, on hepatic cytochrome P450 (CYP) activity in rats.	Curcumin	31-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	114-117
16288784-9	2006	Our results demonstrated that CYP isozyme inactivation in rat liver caused by CCl(4) was inhibited by curcumin.	Curcumin	102-110	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	30-33
16288784-10	2006	Dietary intake of curcumin may protect against CCl(4)-induced hepatic CYP inactivation via its antioxidant properties, without inducing hepatic CYPs.	Curcumin	18-26	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	70-73
16338138-0	2006	Activation of NFkappaB is inhibited by curcumin and related enones.	Curcumin	39-47	nuclear factor kappa B subunit 1	Homo sapiens	14-22
16338138-2	2006	The natural product curcumin is a known inhibitor of activation of NFkappaB.	Curcumin	20-28	nuclear factor kappa B subunit 1	Homo sapiens	67-75
16338138-3	2006	Enone analogues of curcumin were compared with curcumin for their abilities to inhibit the TNFalpha-induced activation of NFkappaB, using the Panomics" NFkappaB Reporter Stable Cell Line.	Curcumin	47-55	tumor necrosis factor	Homo sapiens	91-99
16338138-3	2006	Enone analogues of curcumin were compared with curcumin for their abilities to inhibit the TNFalpha-induced activation of NFkappaB, using the Panomics" NFkappaB Reporter Stable Cell Line.	Curcumin	47-55	nuclear factor kappa B subunit 1	Homo sapiens	122-130
16338138-5	2006	Inhibitors of NFkappaB activation were identified in all three series, a number of which were more active than curcumin.	Curcumin	111-119	nuclear factor kappa B subunit 1	Homo sapiens	14-22
16338138-10	2006	The data suggest that the abilities of curcumin and analogues to prevent the stress-induced activation of NFkappaB result from the inhibition of specific targets rather than from activity as anti-oxidants.	Curcumin	39-47	nuclear factor kappa B subunit 1	Homo sapiens	106-114
16288471-8	2006	Most surprisingly, VCAM-1 expression was also significantly blocked by a selective inhibitor of p300, curcumin.	Curcumin	102-110	vascular cell adhesion molecule 1	Homo sapiens	19-25
16630125-0	2006	Curcumin targets Akt cell survival signaling pathway in HTLV-I-infected T-cell lines.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	17-20
16630125-4	2006	We investigated the effect of curcumin on Akt activity in HTLV-I-infected T-cell lines and primary ATL cells.	Curcumin	30-38	AKT serine/threonine kinase 1	Homo sapiens	42-45
16630125-6	2006	Curcumin reduced phosphorylation of PDK1 and inhibited constitutive activation of Akt.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	82-85
16630125-7	2006	Curcumin activated glycogen synthase kinase (GSK)-3beta, a downstream target of Akt kinase, by inhibiting phosphorylation of this protein.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	80-83
16630125-9	2006	Our results suggest that activation of the Akt signaling pathway plays an important role in ATL cell survival, and that curcumin may have anti-ATL properties mediated, at least in part, by inhibiting Akt activity.	Curcumin	120-128	AKT serine/threonine kinase 1	Homo sapiens	200-203
16294327-8	2006	Curcumin inhibited platelet-derived growth factor (PDGF)-induced proliferation, alpha-smooth muscle actin gene expression, interleukin-1beta- and tumor necrosis factor (TNF)-alpha-induced MCP-1 production, type I collagen production, and expression of type I and type III collagen genes.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	123-140
16294327-9	2006	Curcumin inhibited PDGF-BB-induced cyclin D1 expression and activation of extracellular signal-regulated kinase (ERK).	Curcumin	0-8	cyclin D1	Rattus norvegicus	35-44
16294327-9	2006	Curcumin inhibited PDGF-BB-induced cyclin D1 expression and activation of extracellular signal-regulated kinase (ERK).	Curcumin	0-8	Eph receptor B1	Rattus norvegicus	74-111
16294327-9	2006	Curcumin inhibited PDGF-BB-induced cyclin D1 expression and activation of extracellular signal-regulated kinase (ERK).	Curcumin	0-8	Eph receptor B1	Rattus norvegicus	113-116
16294327-10	2006	Curcumin inhibited interleukin-1beta- and TNF-alpha-induced activation of activator protein-1 (AP-1) and mitogen-activated protein (MAP) kinases (ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase), but not of nuclear factor-kappaB (NF-kappaB).	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	19-36
16294327-10	2006	Curcumin inhibited interleukin-1beta- and TNF-alpha-induced activation of activator protein-1 (AP-1) and mitogen-activated protein (MAP) kinases (ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase), but not of nuclear factor-kappaB (NF-kappaB).	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	42-51
16294327-10	2006	Curcumin inhibited interleukin-1beta- and TNF-alpha-induced activation of activator protein-1 (AP-1) and mitogen-activated protein (MAP) kinases (ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase), but not of nuclear factor-kappaB (NF-kappaB).	Curcumin	0-8	Eph receptor B1	Rattus norvegicus	146-149
16648563-0	2006	Curcumin induces caspase-3-dependent apoptotic pathway but inhibits DNA fragmentation factor 40/caspase-activated DNase endonuclease in human Jurkat cells.	Curcumin	0-8	caspase 3	Homo sapiens	17-26
16648563-6	2006	In biochemical experiments using recombinant DFF activated with caspase-3, we show that curcumin inhibits plasmid DNA and chromatin degradation although it does not prevent activation of DFF40/CAD endonuclease after its release from the inhibitor.	Curcumin	88-96	caspase 3	Homo sapiens	64-73
16830828-6	2006	RESULT: Curcumin can raise the content of SOD and GSH-Px and lessen the level of MDA and iNOS.	Curcumin	8-16	nitric oxide synthase 2	Rattus norvegicus	89-93
16646663-0	2006	Curcumin-induced histone hypoacetylation enhances caspase-3-dependent glioma cell death and neurogenesis of neural progenitor cells.	Curcumin	0-8	caspase 3	Homo sapiens	50-59
16646663-4	2006	Our studies first proved that curcumin induces histone hypoacetylation in brain cancer cells and finally induces apoptotic cell death through a (PARP)- and caspase 3-mediated manner.	Curcumin	30-38	poly(ADP-ribose) polymerase 1	Homo sapiens	145-149
16646663-4	2006	Our studies first proved that curcumin induces histone hypoacetylation in brain cancer cells and finally induces apoptotic cell death through a (PARP)- and caspase 3-mediated manner.	Curcumin	30-38	caspase 3	Homo sapiens	156-165
16638200-0	2006	[Regulatory effect of curcumin on p300 and HDAC1 in B-NHL cells].	Curcumin	22-30	histone deacetylase 1	Homo sapiens	43-48
16638200-1	2006	The purpose of this study was to investigate the effect of curcumin on proliferation of B-NHL Raji cell line and explore the relationship between this effect and regulatory expression of p300 and HDAC1 transcription.	Curcumin	59-67	histone deacetylase 1	Homo sapiens	196-201
16638200-4	2006	The curcumin significantly inhibited activity and expression of p300 and HDAC1.	Curcumin	4-12	histone deacetylase 1	Homo sapiens	73-78
16638200-7	2006	Curcumin can inhibit the activity and expression of the transcriptional co-activator p300 and HDAC1, which may be involved in its pharmacological mechanisms on B lymphoma cells.	Curcumin	0-8	histone deacetylase 1	Homo sapiens	94-99
16368150-10	2006	AP-1-specific inhibitor Curcumin dose-dependently abrogated the effect of IL-18 on VEGF production.	Curcumin	24-32	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
16460683-3	2006	This study examined the role of PKC in ARE-mediated gene regulation in human monocytes by curcumin, a potent inducer of the Nrf2/ARE pathway.	Curcumin	90-98	NFE2 like bZIP transcription factor 2	Homo sapiens	124-128
16460683-4	2006	Curcumin increased HO-1 and glutamyl cysteine ligase modulator (GCLM) expression and stimulated Nrf2 binding to the ARE.	Curcumin	0-8	glutamate-cysteine ligase modifier subunit	Homo sapiens	28-62
16460683-4	2006	Curcumin increased HO-1 and glutamyl cysteine ligase modulator (GCLM) expression and stimulated Nrf2 binding to the ARE.	Curcumin	0-8	glutamate-cysteine ligase modifier subunit	Homo sapiens	64-68
16460683-4	2006	Curcumin increased HO-1 and glutamyl cysteine ligase modulator (GCLM) expression and stimulated Nrf2 binding to the ARE.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
16460683-5	2006	Curcumin also rapidly stimulated PKC phosphorylation and Ro-31-8220, a pan-PKC inhibitor, decreased curcumin-induced GCLM and HO-1 mRNA expression and ARE binding.	Curcumin	0-8	glutamate-cysteine ligase modifier subunit	Homo sapiens	117-121
16460683-5	2006	Curcumin also rapidly stimulated PKC phosphorylation and Ro-31-8220, a pan-PKC inhibitor, decreased curcumin-induced GCLM and HO-1 mRNA expression and ARE binding.	Curcumin	100-108	glutamate-cysteine ligase modifier subunit	Homo sapiens	117-121
16460683-6	2006	Rottlerin (a PKC delta inhibitor) and PKC delta antisense oligonucleotides significantly inhibited curcumin-induced GCLM and HO-1 mRNA expression and ARE binding.	Curcumin	99-107	glutamate-cysteine ligase modifier subunit	Homo sapiens	116-120
16460683-7	2006	Furthermore, a p38 MAP kinase inhibitor reduced GCLM and HO-1 expression and rottlerin inhibited curcumin-induced p38 phosphorylation.	Curcumin	97-105	mitogen-activated protein kinase 14	Homo sapiens	15-18
16460683-7	2006	Furthermore, a p38 MAP kinase inhibitor reduced GCLM and HO-1 expression and rottlerin inhibited curcumin-induced p38 phosphorylation.	Curcumin	97-105	mitogen-activated protein kinase 14	Homo sapiens	114-117
16460683-8	2006	In summary, curcumin activates ARE-mediated gene expression in human monocytes via PKC delta, upstream of p38 and Nrf2.	Curcumin	12-20	mitogen-activated protein kinase 14	Homo sapiens	106-109
16460683-8	2006	In summary, curcumin activates ARE-mediated gene expression in human monocytes via PKC delta, upstream of p38 and Nrf2.	Curcumin	12-20	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
16476424-3	2006	In addition, curcumin stimulated the expression of mRNA for p21(WAF1/CIP1), which inhibits the activity of cyclin-dependent kinases, and inhibited the phosphorylation of histone H1.	Curcumin	13-21	cyclin dependent kinase inhibitor 1A	Homo sapiens	60-63
16476424-3	2006	In addition, curcumin stimulated the expression of mRNA for p21(WAF1/CIP1), which inhibits the activity of cyclin-dependent kinases, and inhibited the phosphorylation of histone H1.	Curcumin	13-21	cyclin dependent kinase inhibitor 1A	Homo sapiens	64-68
16476424-3	2006	In addition, curcumin stimulated the expression of mRNA for p21(WAF1/CIP1), which inhibits the activity of cyclin-dependent kinases, and inhibited the phosphorylation of histone H1.	Curcumin	13-21	cyclin dependent kinase inhibitor 1A	Homo sapiens	69-73
16476424-5	2006	Our results indicate that curcumin might inhibit the proliferation and mineralization of osteoblastic cells through the expression of p21(WAF1/CIP1).	Curcumin	26-34	cyclin dependent kinase inhibitor 1A	Homo sapiens	134-137
16476424-5	2006	Our results indicate that curcumin might inhibit the proliferation and mineralization of osteoblastic cells through the expression of p21(WAF1/CIP1).	Curcumin	26-34	cyclin dependent kinase inhibitor 1A	Homo sapiens	138-142
16476424-5	2006	Our results indicate that curcumin might inhibit the proliferation and mineralization of osteoblastic cells through the expression of p21(WAF1/CIP1).	Curcumin	26-34	cyclin dependent kinase inhibitor 1A	Homo sapiens	143-147
16368150-10	2006	AP-1-specific inhibitor Curcumin dose-dependently abrogated the effect of IL-18 on VEGF production.	Curcumin	24-32	vascular endothelial growth factor A	Homo sapiens	83-87
16354769-4	2006	Curcumin or hemin (20 microM) induced HO-1 in breast cells from 5 to 24 h. Curcumin (5-40 microM) or hemin (5-100 microM) induced HO-1 and nuclear levels of nuclear factor (erythroid-derived 2)-related factor (Nrf2) in a dose-dependent manner.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	210-214
16376585-5	2006	A decrease in expression of Bcl-2, Bcl-X(L) and pro-caspase-3 was observed after exposure to 40 microM curcumin, while the levels of p53 and Bax were increased in the curcumin-treated cells.	Curcumin	103-111	BCL2 apoptosis regulator	Homo sapiens	28-33
16376585-5	2006	A decrease in expression of Bcl-2, Bcl-X(L) and pro-caspase-3 was observed after exposure to 40 microM curcumin, while the levels of p53 and Bax were increased in the curcumin-treated cells.	Curcumin	103-111	BCL2 like 1	Homo sapiens	35-43
16376585-5	2006	A decrease in expression of Bcl-2, Bcl-X(L) and pro-caspase-3 was observed after exposure to 40 microM curcumin, while the levels of p53 and Bax were increased in the curcumin-treated cells.	Curcumin	103-111	caspase 3	Homo sapiens	48-61
16376585-5	2006	A decrease in expression of Bcl-2, Bcl-X(L) and pro-caspase-3 was observed after exposure to 40 microM curcumin, while the levels of p53 and Bax were increased in the curcumin-treated cells.	Curcumin	103-111	tumor protein p53	Homo sapiens	133-136
16376585-5	2006	A decrease in expression of Bcl-2, Bcl-X(L) and pro-caspase-3 was observed after exposure to 40 microM curcumin, while the levels of p53 and Bax were increased in the curcumin-treated cells.	Curcumin	103-111	BCL2 associated X, apoptosis regulator	Homo sapiens	141-144
16376585-5	2006	A decrease in expression of Bcl-2, Bcl-X(L) and pro-caspase-3 was observed after exposure to 40 microM curcumin, while the levels of p53 and Bax were increased in the curcumin-treated cells.	Curcumin	167-175	BCL2 like 1	Homo sapiens	35-43
16376585-5	2006	A decrease in expression of Bcl-2, Bcl-X(L) and pro-caspase-3 was observed after exposure to 40 microM curcumin, while the levels of p53 and Bax were increased in the curcumin-treated cells.	Curcumin	167-175	caspase 3	Homo sapiens	48-61
16376585-5	2006	A decrease in expression of Bcl-2, Bcl-X(L) and pro-caspase-3 was observed after exposure to 40 microM curcumin, while the levels of p53 and Bax were increased in the curcumin-treated cells.	Curcumin	167-175	tumor protein p53	Homo sapiens	133-136
16376585-5	2006	A decrease in expression of Bcl-2, Bcl-X(L) and pro-caspase-3 was observed after exposure to 40 microM curcumin, while the levels of p53 and Bax were increased in the curcumin-treated cells.	Curcumin	167-175	BCL2 associated X, apoptosis regulator	Homo sapiens	141-144
16787365-4	2006	In cells, curcumin promoted proteasome-dependent degradation of p300 and the closely related CBP protein without affecting the HATs PCAF or GCN5.	Curcumin	10-18	CREB binding protein	Homo sapiens	93-96
16787365-5	2006	In addition to inducing p300 degradation curcumin inhibited the acetyltransferase activity of purified p300 as assessed using either histone H3 or p53 as substrate.	Curcumin	41-49	tumor protein p53	Homo sapiens	147-150
16787365-8	2006	These data thus identify the medicinal natural product curcumin as a novel lead compound for development of possibly therapeutic, p300/CBP-specific HAT inhibitors.	Curcumin	55-63	CREB binding protein	Homo sapiens	135-138
16490174-0	2006	Curcumin inhibits WT1 gene expression in human leukemic K562 cells.	Curcumin	0-8	WT1 transcription factor	Homo sapiens	18-21
16490174-3	2006	The purpose of this study was to investigate the modulating effects of curcumin on WT1 gene expression in the human leukemic cell line K562.	Curcumin	71-79	WT1 transcription factor	Homo sapiens	83-86
16490174-5	2006	The K562 cell line was treated with a non-cytotoxic dose of curcumin (5, 10, or 15 micromol/L) for 13 d. The expression levels of WT1 protein and WT1 mRNA were assessed by Western blot analysis and reverse transcription-polymerase chain reaction (RT-PCR), respectively.	Curcumin	60-68	WT1 transcription factor	Homo sapiens	130-133
16490174-5	2006	The K562 cell line was treated with a non-cytotoxic dose of curcumin (5, 10, or 15 micromol/L) for 13 d. The expression levels of WT1 protein and WT1 mRNA were assessed by Western blot analysis and reverse transcription-polymerase chain reaction (RT-PCR), respectively.	Curcumin	60-68	WT1 transcription factor	Homo sapiens	146-149
16490174-7	2006	Non-cytotoxic doses of curcumin, at concentrations of 5, 10, and 15 micromol/L for 2 d, decreased the level of WT1 protein and WT1 mRNA in the K562 cell line in a dose-dependent manner.	Curcumin	23-31	WT1 transcription factor	Homo sapiens	111-114
16490174-7	2006	Non-cytotoxic doses of curcumin, at concentrations of 5, 10, and 15 micromol/L for 2 d, decreased the level of WT1 protein and WT1 mRNA in the K562 cell line in a dose-dependent manner.	Curcumin	23-31	WT1 transcription factor	Homo sapiens	127-130
16490174-8	2006	Similarly, curcumin at a concentration of 10 micromol/L significantly decreased the level of WT1 protein and mRNA in a time-dependent manner.	Curcumin	11-19	WT1 transcription factor	Homo sapiens	93-96
16490174-9	2006	CONCLUSION: The inhibitory effects of curcumin are associated with a decrease in the levels of both WT1 protein and WT1 mRNA.	Curcumin	38-46	WT1 transcription factor	Homo sapiens	100-103
16490174-9	2006	CONCLUSION: The inhibitory effects of curcumin are associated with a decrease in the levels of both WT1 protein and WT1 mRNA.	Curcumin	38-46	WT1 transcription factor	Homo sapiens	116-119
16299382-0	2006	Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin.	Curcumin	131-139	epidermal growth factor receptor	Homo sapiens	14-18
16299382-7	2006	Studying upstream signaling events, we found that the phosphorylations of IkappaBalpha and Akt (Ser473, Thr308) were significantly attenuated by the combination of PEITC and curcumin.	Curcumin	174-182	NFKB inhibitor alpha	Homo sapiens	74-86
16299382-7	2006	Studying upstream signaling events, we found that the phosphorylations of IkappaBalpha and Akt (Ser473, Thr308) were significantly attenuated by the combination of PEITC and curcumin.	Curcumin	174-182	AKT serine/threonine kinase 1	Homo sapiens	91-94
16299382-8	2006	As these events can be downstream of the activation of epidermal growth factor receptor (EGFR), we pretreated PC-3 cells with PEITC and curcumin and then stimulated them with EGF.	Curcumin	136-144	epidermal growth factor receptor	Homo sapiens	55-87
16299382-8	2006	As these events can be downstream of the activation of epidermal growth factor receptor (EGFR), we pretreated PC-3 cells with PEITC and curcumin and then stimulated them with EGF.	Curcumin	136-144	epidermal growth factor receptor	Homo sapiens	89-93
16299382-9	2006	EGFR phosphorylations (Y845 and Y1068) were dramatically suppressed by PEITC or curcumin, and more so by the combination.	Curcumin	80-88	epidermal growth factor receptor	Homo sapiens	0-4
16299382-11	2006	We conclude that the simultaneous targeting of EGFR, Akt and NF-kappaB signaling pathways by PEITC and curcumin could be the molecular targets by which PEITC and curcumin exert their additive inhibitory effects on cell proliferation and ultimately lead to programmed cell death of tumor cells.	Curcumin	103-111	epidermal growth factor receptor	Homo sapiens	47-51
16299382-11	2006	We conclude that the simultaneous targeting of EGFR, Akt and NF-kappaB signaling pathways by PEITC and curcumin could be the molecular targets by which PEITC and curcumin exert their additive inhibitory effects on cell proliferation and ultimately lead to programmed cell death of tumor cells.	Curcumin	103-111	AKT serine/threonine kinase 1	Homo sapiens	53-56
16299382-11	2006	We conclude that the simultaneous targeting of EGFR, Akt and NF-kappaB signaling pathways by PEITC and curcumin could be the molecular targets by which PEITC and curcumin exert their additive inhibitory effects on cell proliferation and ultimately lead to programmed cell death of tumor cells.	Curcumin	162-170	epidermal growth factor receptor	Homo sapiens	47-51
16299382-11	2006	We conclude that the simultaneous targeting of EGFR, Akt and NF-kappaB signaling pathways by PEITC and curcumin could be the molecular targets by which PEITC and curcumin exert their additive inhibitory effects on cell proliferation and ultimately lead to programmed cell death of tumor cells.	Curcumin	162-170	AKT serine/threonine kinase 1	Homo sapiens	53-56
16354769-4	2006	Curcumin or hemin (20 microM) induced HO-1 in breast cells from 5 to 24 h. Curcumin (5-40 microM) or hemin (5-100 microM) induced HO-1 and nuclear levels of nuclear factor (erythroid-derived 2)-related factor (Nrf2) in a dose-dependent manner.	Curcumin	75-83	NFE2 like bZIP transcription factor 2	Homo sapiens	210-214
16354769-9	2006	Curcumin and hemin also induced nuclear Nrf2 and HO-1 effectively in wild-type mouse embryo fibroblasts (wt MEFs) and in B-Raf(-/-) MEFs but not in Nrf2(-/-) MEFs.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	40-44
16021489-3	2006	In this study, curcumin mixture and three major curcuminoids purified from turmeric (curcumin I, II, and III) were tested for their ability to modulate the function of MRP1 using HEK293 cells stably transfected with MRP1-pcDNA3.1 and pcDNA3.1 vector alone.	Curcumin	15-23	ATP binding cassette subfamily C member 1	Homo sapiens	168-172
16021489-10	2006	In summary, these results demonstrate that curcuminoids effectively inhibit MRP1-mediated transport and among curcuminoids, curcumin I, a major constituent of curcumin mixture, is the best modulator.	Curcumin	124-134	ATP binding cassette subfamily C member 1	Homo sapiens	76-80
16021489-10	2006	In summary, these results demonstrate that curcuminoids effectively inhibit MRP1-mediated transport and among curcuminoids, curcumin I, a major constituent of curcumin mixture, is the best modulator.	Curcumin	43-51	ATP binding cassette subfamily C member 1	Homo sapiens	76-80
16702625-4	2006	Intragastric administration of BDMCA or curcumin to DMH-treated rats significantly decreased colon tumor incidence and the circulatory LPO, with simultaneous enhancement of GSH content and GPx, GST, SOD and CAT activities.	Curcumin	40-48	catalase	Rattus norvegicus	207-210
16502262-0	2006	Curcumin induces apoptosis via inhibition of PI3"-kinase/AKT pathway in acute T cell leukemias.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	57-60
16502262-5	2006	Curcumin treatment causes the de-phosphorylation/inactivation of constitutively active AKT, FOXO transcription factor and GSK3.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	87-90
16502262-6	2006	Curcumin also induces release of cytochrome c accompanied by activation of caspase-3 and PARP cleavage.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	33-45
16502262-6	2006	Curcumin also induces release of cytochrome c accompanied by activation of caspase-3 and PARP cleavage.	Curcumin	0-8	caspase 3	Homo sapiens	75-84
16502262-6	2006	Curcumin also induces release of cytochrome c accompanied by activation of caspase-3 and PARP cleavage.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	89-93
16502262-9	2006	Taken together, our finding suggest that curcumin suppresses constitutively activated targets of PI3"-kinase (AKT, FOXO and GSK3) in T cells leading to the inhibition of proliferation and induction of caspase-dependent apoptosis.	Curcumin	41-49	AKT serine/threonine kinase 1	Homo sapiens	110-113
16210389-5	2006	Curcumin (10(-8) mol/l), a known nuclear factor (NF)-kappaB inhibitor, inhibited the TNF-alpha-induced pIkappaB phosphorylation as shown by western blotting, NF-kappaB translocation into the nucleus as shown by electrophoretic mobility shift assay, and MIF synthesis and secretion as measured by ELISA and RT-PCR.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	85-94
16210389-5	2006	Curcumin (10(-8) mol/l), a known nuclear factor (NF)-kappaB inhibitor, inhibited the TNF-alpha-induced pIkappaB phosphorylation as shown by western blotting, NF-kappaB translocation into the nucleus as shown by electrophoretic mobility shift assay, and MIF synthesis and secretion as measured by ELISA and RT-PCR.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	158-167
16454490-6	2006	This curcumin-loaded PLLA material was then modified using adsorptive coating of adhesive proteins such as fibronectin, collagen-I, vitronectin, laminin, and matrigel to improve the endothelial cell (EC) adhesion and proliferation, and ECs were seeded on top of these modified surfaces.	Curcumin	5-13	fibronectin 1	Homo sapiens	107-118
16951739-5	2006	RESULTS: Curcumin decreased cell viability, activated caspase-3 and decreased the level of DFF45/ICAD, the inhibitor of the DFF40/CAD endonuclease.	Curcumin	9-17	caspase 3	Homo sapiens	54-63
16491848-0	2006	Inhibitory effect of curcumin on WT1 gene expression in patient leukemic cells.	Curcumin	21-29	WT1 transcription factor	Homo sapiens	33-36
16491848-5	2006	The objective of this study was to investigate the effect of curcumin on WT1 gene expression in patient leukemic cells.	Curcumin	61-69	WT1 transcription factor	Homo sapiens	73-76
16491848-10	2006	The result showed that curcumin reduced WT1 gene expression in the cells from 35 patients (50%).	Curcumin	23-31	WT1 transcription factor	Homo sapiens	40-43
16491848-13	2006	In summary, curcumin decreased WT1 mRNA in patient leukemic cells.	Curcumin	12-20	WT1 transcription factor	Homo sapiens	31-34
16106398-0	2006	Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	58-67
16106398-0	2006	Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells.	Curcumin	10-27	nuclear factor kappa B subunit 1	Homo sapiens	58-67
16106398-7	2006	Curcumin suppressed constitutive active NF-kappaB of HTLV-I-infected T-cell lines and primary ATL cells by inhibiting phosphorylation of IkappaBalpha.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	40-49
16106398-8	2006	Curcumin also inhibited Tax-induced NF-kappaB transcriptional activity.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	36-45
16509859-11	2006	Curcumin treatment also reduced the TAA-induced elevated hepatic levels of thiobarbituric acid-reactive substances (TBARS), and inhibited the nuclear binding of nuclear factor kappa B (NFkappaB) and inducible nitric oxide (iNOS) protein expression.	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	223-227
16411910-2	2006	The aim of this study was to investigate the effects of curcumin on inflammatory cytokines, such as tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 in the late phase of AP.	Curcumin	56-64	tumor necrosis factor	Rattus norvegicus	100-134
16411910-2	2006	The aim of this study was to investigate the effects of curcumin on inflammatory cytokines, such as tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 in the late phase of AP.	Curcumin	56-64	interleukin 6	Rattus norvegicus	139-157
16411910-12	2006	Serum TNF-alpha and IL-6 levels in the group, which received curcumin (group I), were determined to be significantly lower than those of the untreated group (group II) (P&lt;0.05).	Curcumin	61-69	tumor necrosis factor	Rattus norvegicus	6-15
16411910-12	2006	Serum TNF-alpha and IL-6 levels in the group, which received curcumin (group I), were determined to be significantly lower than those of the untreated group (group II) (P&lt;0.05).	Curcumin	61-69	interleukin 6	Rattus norvegicus	20-24
16411910-14	2006	Curcumin has been shown to markedly reduce serum TNF-alpha and IL-6 levels in the late phase of AP, but failed in the prevention of tissue injury.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	49-58
16411910-14	2006	Curcumin has been shown to markedly reduce serum TNF-alpha and IL-6 levels in the late phase of AP, but failed in the prevention of tissue injury.	Curcumin	0-8	interleukin 6	Rattus norvegicus	63-67
16170359-0	2006	Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	83-115
16170359-4	2006	We recently reported that curcumin inhibited the growth of human colon cancer-derived Moser cells by suppressing gene expression of cyclinD1 and EGFR.	Curcumin	26-34	epidermal growth factor receptor	Homo sapiens	145-149
16170359-5	2006	The aim of the present study was to explore the molecular mechanisms underlying curcumin inhibition of gene expression of EGFR in colon cancer cells.	Curcumin	80-88	epidermal growth factor receptor	Homo sapiens	122-126
16170359-6	2006	The generality of the inhibitory effect of curcumin on gene expression of EGFR was verified in other human colon cancer-derived cell lines, including Caco-2 and HT-29 cells.	Curcumin	43-51	epidermal growth factor receptor	Homo sapiens	74-78
16170359-7	2006	Promoter deletion assays and site-directed mutageneses identified a binding site for the transcription factor early growth response-1 (Egr-1) in egfr promoter as a putative curcumin response element in regulating the promoter activity of the gene in Moser cells.	Curcumin	173-181	epidermal growth factor receptor	Homo sapiens	145-149
16170359-10	2006	Taken together, our results demonstrated that curcumin inhibited human colon cancer cell growth by suppressing gene expression of EGFR through reducing the trans-activation activity of Egr-1.	Curcumin	46-54	epidermal growth factor receptor	Homo sapiens	130-134
17473375-5	2006	Curcumin, structurally related with caffeic acid and an element of turmeric, induced the HO-1 gene to 5.8-fold.	Curcumin	0-8	heme oxygenase 1	Mus musculus	89-93
16454490-9	2006	Moreover, coating with fibronectin on curcumin-loaded PLLA surfaces gave the highest EC adhesion and proliferation compared to other adhesive proteins using PicoGreen DNA assays.	Curcumin	38-46	fibronectin 1	Homo sapiens	23-34
16737669-3	2006	Several studies indicate that curcumin may exert its effect by specifically inhibiting the cyclooxygenase-2 (COX-2) isoenzyme, which is up-regulated in 40 to 50% of colorectal polyps and in up to 85% of CRCs.	Curcumin	30-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	91-107
16340194-2	2006	Curcumin, a major yellow pigment in turmeric which is used widely all over the world, inhibits the growth of human colon cancer cell line HT-29 significantly and specifically inhibits the expression of COX-2 protein.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	202-207
16850746-1	2006	Histone deacetylase (HDAC1) has a high expression in many cancer cells and curcumin can inhibit the growth of cancer cells.	Curcumin	75-83	histone deacetylase 1	Homo sapiens	21-26
16850746-6	2006	The up-regulation of HDAC1 expression was observed within 24 h after the treatment with curcumin as shown by RT-PCR and Western blot.	Curcumin	88-96	histone deacetylase 1	Homo sapiens	21-26
16737669-3	2006	Several studies indicate that curcumin may exert its effect by specifically inhibiting the cyclooxygenase-2 (COX-2) isoenzyme, which is up-regulated in 40 to 50% of colorectal polyps and in up to 85% of CRCs.	Curcumin	30-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	109-114
16737669-4	2006	However, other studies have suggested that curcumin may also inhibit polyps formation by COX-2 independent mechanisms (eg, inhibition of ErbB-1, AkT).	Curcumin	43-51	prostaglandin-endoperoxide synthase 2	Homo sapiens	89-94
16737669-4	2006	However, other studies have suggested that curcumin may also inhibit polyps formation by COX-2 independent mechanisms (eg, inhibition of ErbB-1, AkT).	Curcumin	43-51	epidermal growth factor receptor	Homo sapiens	137-143
16737669-4	2006	However, other studies have suggested that curcumin may also inhibit polyps formation by COX-2 independent mechanisms (eg, inhibition of ErbB-1, AkT).	Curcumin	43-51	AKT serine/threonine kinase 1	Homo sapiens	145-148
16737669-5	2006	The aim of this study was to evaluate whether curcumin"s effect on the inhibition of cell growth and induction of apoptosis in human colon carcinoma cell lines is correlated with inhibition of PGE2 synthesis and down-regulation of COX-2.	Curcumin	46-54	prostaglandin-endoperoxide synthase 2	Homo sapiens	231-236
16598650-6	2006	AP-1 inhibitor curcumin also inhibited TGF-beta1-induced alpha-SMA expression.	Curcumin	15-23	transforming growth factor beta 1	Homo sapiens	39-48
16737669-12	2006	There was a significant difference between curcumin effect on COX-2-expressing (HT29: inhibitory concentration 50% [IC50] = 15 microM) and COX-2-deficient (SW480: IC50 = 40 microM) cells.	Curcumin	43-51	prostaglandin-endoperoxide synthase 2	Homo sapiens	62-67
16737669-14	2006	Western blot analysis and PGE2 immunoassay showed that curcumin inhibited COX-2 protein activity and expression in a dose-dependent manner.	Curcumin	55-63	prostaglandin-endoperoxide synthase 2	Homo sapiens	74-79
16737669-15	2006	In conclusion, inhibition of cell survival and induction of apoptosis by curcumin in colorectal adenocarcinoma cell lines is associated with the inhibition of PGE2 synthesis and down-regulation of COX-2.	Curcumin	73-81	prostaglandin-endoperoxide synthase 2	Homo sapiens	197-202
16219905-0	2006	Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.	Curcumin	0-8	NFKB inhibitor alpha	Homo sapiens	147-159
16432161-2	2006	Our objective is to study global gene expression profiles elicited by curcumin in mouse liver and small intestine as well as to identify curcumin-regulated nuclear factor E2-related factor 2 (Nrf2)-dependent genes.	Curcumin	137-145	nuclear factor, erythroid derived 2, like 2	Mus musculus	192-196
16432161-6	2006	Genes that were induced or suppressed &gt;2-fold by curcumin treatments compared with vehicle in wild-type mice but not in knockout mice were filtered using GeneSpring software and regarded as Nrf2-dependent genes.	Curcumin	52-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	193-197
16432161-7	2006	Among those well-defined genes, 822 (664 induced and 158 suppressed) and 222 (154 induced and 68 suppressed) were curcumin-regulated Nrf2-dependent genes identified in the liver and small intestine, respectively.	Curcumin	114-122	nuclear factor, erythroid derived 2, like 2	Mus musculus	133-137
16432161-10	2006	The identification of curcumin-regulated Nrf2-dependent genes not only provides potential novel insights into the biological effects of curcumin on global gene expression and chemoprevention but also points to the potential role of Nrf2 in these processes.	Curcumin	22-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	41-45
16432161-10	2006	The identification of curcumin-regulated Nrf2-dependent genes not only provides potential novel insights into the biological effects of curcumin on global gene expression and chemoprevention but also points to the potential role of Nrf2 in these processes.	Curcumin	22-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	232-236
16432161-10	2006	The identification of curcumin-regulated Nrf2-dependent genes not only provides potential novel insights into the biological effects of curcumin on global gene expression and chemoprevention but also points to the potential role of Nrf2 in these processes.	Curcumin	136-144	nuclear factor, erythroid derived 2, like 2	Mus musculus	41-45
16432161-10	2006	The identification of curcumin-regulated Nrf2-dependent genes not only provides potential novel insights into the biological effects of curcumin on global gene expression and chemoprevention but also points to the potential role of Nrf2 in these processes.	Curcumin	136-144	nuclear factor, erythroid derived 2, like 2	Mus musculus	232-236
16219905-10	2006	We found that curcumin suppressed TNF-induced nuclear translocation of p65, which corresponded with the sequential suppression of IkappaBalpha kinase activity, IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation, p65 nuclear translocation, and p65 acetylation.	Curcumin	14-22	NFKB inhibitor alpha	Homo sapiens	160-172
16219905-0	2006	Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	171-174
16219905-11	2006	Curcumin also inhibited TNF-induced Akt activation and its association with IKK.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	24-27
16219905-11	2006	Curcumin also inhibited TNF-induced Akt activation and its association with IKK.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	36-39
16219905-0	2006	Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.	Curcumin	10-27	NFKB inhibitor alpha	Homo sapiens	147-159
16219905-12	2006	Glutathione and dithiothreitol reversed the effect of curcumin on TNF-induced NF-kappaB activation.	Curcumin	54-62	tumor necrosis factor	Homo sapiens	66-69
16219905-13	2006	Overall, our results indicated that curcumin inhibits NF-kappaB activation and NF-kappaB-regulated gene expression through inhibition of IKK and Akt activation.	Curcumin	36-44	AKT serine/threonine kinase 1	Homo sapiens	145-148
16219905-0	2006	Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.	Curcumin	10-27	AKT serine/threonine kinase 1	Homo sapiens	171-174
16219905-5	2006	Screening of 20 different analogs of curcumin showed that curcumin was the most potent analog in suppressing the tumor necrosis factor (TNF)-induced NF-kappaB activation.	Curcumin	37-45	tumor necrosis factor	Homo sapiens	113-134
16219905-5	2006	Screening of 20 different analogs of curcumin showed that curcumin was the most potent analog in suppressing the tumor necrosis factor (TNF)-induced NF-kappaB activation.	Curcumin	37-45	tumor necrosis factor	Homo sapiens	136-139
16219905-5	2006	Screening of 20 different analogs of curcumin showed that curcumin was the most potent analog in suppressing the tumor necrosis factor (TNF)-induced NF-kappaB activation.	Curcumin	58-66	tumor necrosis factor	Homo sapiens	113-134
16219905-5	2006	Screening of 20 different analogs of curcumin showed that curcumin was the most potent analog in suppressing the tumor necrosis factor (TNF)-induced NF-kappaB activation.	Curcumin	58-66	tumor necrosis factor	Homo sapiens	136-139
16219905-6	2006	Curcumin inhibited TNF-induced NF-kappaB-dependent reporter gene expression in a dose-dependent manner.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	19-22
16219905-9	2006	COX-2 promoter activity induced by TNF was abrogated by curcumin.	Curcumin	56-64	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
16219905-9	2006	COX-2 promoter activity induced by TNF was abrogated by curcumin.	Curcumin	56-64	tumor necrosis factor	Homo sapiens	35-38
16219905-10	2006	We found that curcumin suppressed TNF-induced nuclear translocation of p65, which corresponded with the sequential suppression of IkappaBalpha kinase activity, IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation, p65 nuclear translocation, and p65 acetylation.	Curcumin	14-22	tumor necrosis factor	Homo sapiens	34-37
16219905-10	2006	We found that curcumin suppressed TNF-induced nuclear translocation of p65, which corresponded with the sequential suppression of IkappaBalpha kinase activity, IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation, p65 nuclear translocation, and p65 acetylation.	Curcumin	14-22	NFKB inhibitor alpha	Homo sapiens	130-142
16219905-10	2006	We found that curcumin suppressed TNF-induced nuclear translocation of p65, which corresponded with the sequential suppression of IkappaBalpha kinase activity, IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation, p65 nuclear translocation, and p65 acetylation.	Curcumin	14-22	NFKB inhibitor alpha	Homo sapiens	160-172
16438902-0	2005	Effects of TNF-alpha and curcumin on the expression of VEGF in Raji and U937 cells and on angiogenesis in ECV304 cells.	Curcumin	25-33	vascular endothelial growth factor A	Homo sapiens	55-59
16464750-4	2006	Like other proteasome inhibitors, curcumin exposure induces neurite outgrowth and the stress response, as evident from the induction of various cytosolic and endoplasmic reticulum chaperones as well as induction of transcription factor CHOP/GADD153.	Curcumin	34-42	DNA damage inducible transcript 3	Homo sapiens	236-240
16464750-4	2006	Like other proteasome inhibitors, curcumin exposure induces neurite outgrowth and the stress response, as evident from the induction of various cytosolic and endoplasmic reticulum chaperones as well as induction of transcription factor CHOP/GADD153.	Curcumin	34-42	DNA damage inducible transcript 3	Homo sapiens	241-248
17044774-7	2006	Whereas curcumin inhibited constitutive activation of both EGFR and IGF-1R, ERRP decreased activation of EGFR, ErbB-2, and ErbB-3 but had no effect on IGF-1R.	Curcumin	8-16	epidermal growth factor receptor	Homo sapiens	59-63
16470913-3	2006	RESULTS: In the dose-effect study, soybean isoflavone, luteolin and curcumin induced the CYP3A4 transcription via PXR in an evident dose-dependent manner, but isorhamnetin and rutin did not.	Curcumin	68-76	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	89-95
16470913-3	2006	RESULTS: In the dose-effect study, soybean isoflavone, luteolin and curcumin induced the CYP3A4 transcription via PXR in an evident dose-dependent manner, but isorhamnetin and rutin did not.	Curcumin	68-76	nuclear receptor subfamily 1 group I member 2	Homo sapiens	114-117
16470913-5	2006	In the time-effect study, 10 micromol/L and 50 micromol/L soybean isoflavone, luteolin and curcumin induced CYP3A4 transcription between 12 h and 48 h, the strongest induction appeared in 48 h. 48 h after induction, 50 micromol/L soybean isoflavone, luteolin and curcumin exhibited a 6.72-fold, 3.24-fold, and 2.13-fold increase respectively, compared with 0.1% DMSO treated cells.	Curcumin	91-99	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-114
16470913-5	2006	In the time-effect study, 10 micromol/L and 50 micromol/L soybean isoflavone, luteolin and curcumin induced CYP3A4 transcription between 12 h and 48 h, the strongest induction appeared in 48 h. 48 h after induction, 50 micromol/L soybean isoflavone, luteolin and curcumin exhibited a 6.72-fold, 3.24-fold, and 2.13-fold increase respectively, compared with 0.1% DMSO treated cells.	Curcumin	263-271	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-114
16470913-6	2006	CONCLUSION: Three phytochemicals, i.e. soybean isoflavone, luteolin and curcumin stimulate the PXR-mediated transcription of CYP3A4.	Curcumin	72-80	nuclear receptor subfamily 1 group I member 2	Homo sapiens	95-98
16470913-6	2006	CONCLUSION: Three phytochemicals, i.e. soybean isoflavone, luteolin and curcumin stimulate the PXR-mediated transcription of CYP3A4.	Curcumin	72-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	125-131
16438902-1	2005	BACKGROUND: To better understand the possibilities of antiangiogenic tumor therapy and to assess possible side effects, we investigated the effect of tumour necrosis factor (TNF)-alpha and curcumin on the expression of vascular endothelial growth factor (VEGF) in U937 and Raji cell lines and their effect on angiogenesis in a human umbilical vein endothelial cell (HUVECs)-derived cell line (ECV304), and also the relationship between Notch1 and VEGF.	Curcumin	189-197	vascular endothelial growth factor A	Homo sapiens	219-253
16438902-6	2005	RESULTS: Secretion of VEGF by U937 and Raji cells was increased by TNF-alpha treatment and suppressed by curcumin (P &lt; 0.01).	Curcumin	105-113	vascular endothelial growth factor A	Homo sapiens	22-26
16438902-12	2005	CONCLUSIONS: Expressions of VEGF mRNA in U937 and Raji cells were increased by TNF-alpha and suppressed by curcumin.	Curcumin	107-115	vascular endothelial growth factor A	Homo sapiens	28-32
16356124-0	2005	Curcumin inhibits phorbol ester-induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	57-104
15992833-5	2005	Some of these agents (EGCG, genistein, and curcumin) appear to directly target specific RTKs, and all of these compounds cause inhibition of the activity of the transcription factors AP-1 and NF-kappaB, thus inhibiting cell proliferation and enhancing apoptosis.	Curcumin	43-51	nuclear factor kappa B subunit 1	Homo sapiens	192-201
16302093-0	2005	Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression.	Curcumin	0-8	tumor protein p53	Homo sapiens	79-82
16302093-5	2005	The colon adenocarcinoma cells were treated with curcumin (0-75 microM) for 0-24 h. We observed that p53 was highly expressed in HT-29 cells and curcumin could up-regulate the serine phosphorylation of p53 in a time- and concentration-dependent manner.	Curcumin	49-57	tumor protein p53	Homo sapiens	101-104
16302093-5	2005	The colon adenocarcinoma cells were treated with curcumin (0-75 microM) for 0-24 h. We observed that p53 was highly expressed in HT-29 cells and curcumin could up-regulate the serine phosphorylation of p53 in a time- and concentration-dependent manner.	Curcumin	49-57	tumor protein p53	Homo sapiens	202-205
16302093-5	2005	The colon adenocarcinoma cells were treated with curcumin (0-75 microM) for 0-24 h. We observed that p53 was highly expressed in HT-29 cells and curcumin could up-regulate the serine phosphorylation of p53 in a time- and concentration-dependent manner.	Curcumin	145-153	tumor protein p53	Homo sapiens	101-104
16302093-5	2005	The colon adenocarcinoma cells were treated with curcumin (0-75 microM) for 0-24 h. We observed that p53 was highly expressed in HT-29 cells and curcumin could up-regulate the serine phosphorylation of p53 in a time- and concentration-dependent manner.	Curcumin	145-153	tumor protein p53	Homo sapiens	202-205
16302093-6	2005	An increase in expression of the pro-apoptotic factor Bax and a decrease in expression of the anti-apoptotic factor Bcl-2 were also observed in a time-dependent manner after exposure of 50 microM curcumin, while the expression of the anti-apoptotic factor Bcl-xL was unchanged.	Curcumin	196-204	BCL2 associated X, apoptosis regulator	Homo sapiens	54-57
16302093-6	2005	An increase in expression of the pro-apoptotic factor Bax and a decrease in expression of the anti-apoptotic factor Bcl-2 were also observed in a time-dependent manner after exposure of 50 microM curcumin, while the expression of the anti-apoptotic factor Bcl-xL was unchanged.	Curcumin	196-204	BCL2 apoptosis regulator	Homo sapiens	116-121
16302093-6	2005	An increase in expression of the pro-apoptotic factor Bax and a decrease in expression of the anti-apoptotic factor Bcl-2 were also observed in a time-dependent manner after exposure of 50 microM curcumin, while the expression of the anti-apoptotic factor Bcl-xL was unchanged.	Curcumin	196-204	BCL2 like 1	Homo sapiens	256-262
16302093-7	2005	Curcumin could also down-regulate the expression of pro-caspase-3 and pro-caspase-9 in a time-dependent manner.	Curcumin	0-8	caspase 3	Homo sapiens	52-65
16302093-8	2005	These data suggest a possible underlying molecular mechanism whereby curcumin could induce the apoptosis signaling pathway in human HT-29 colon adenocarcinoma cells by p53 activation and by the regulation of apoptosis-related proteins.	Curcumin	69-77	tumor protein p53	Homo sapiens	168-171
16361152-0	2005	[Apoptosis induced by curcumin and its effect on c-myc and caspase-3 expressions in human melanoma A375 cell line].	Curcumin	22-30	caspase 3	Homo sapiens	59-68
16361152-8	2005	c-myc expression level was decreased whereas caspase-3 expression increased with the increase in curcumin concentrations.	Curcumin	97-105	caspase 3	Homo sapiens	45-54
16391419-3	2005	We hypothesized that curcumin could inhibit the development of atherosclerosis in the apoE/LDLR-double knockout mice fed with Western diet (21% fat, 0.15% cholesterol w/w, without cholic acid).	Curcumin	21-29	apolipoprotein E	Mus musculus	86-90
16391419-7	2005	To our knowledge, this is the first report that shows the anti-atherogenic effect of low dose of curcumin in fine model of atherosclerosis: gene-targeted apoE/LDLR-double knockout mice.	Curcumin	97-105	apolipoprotein E	Mus musculus	154-158
19079906-3	2005	The polyphenolic compound curcumin exhibits antioxidant and anti-inflammatory properties, inhibits NF-kappaB and activates PPAR-gamma.	Curcumin	26-34	peroxisome proliferator activated receptor gamma	Homo sapiens	123-133
19079906-5	2005	Indirect evidence suggests that curcumin may improve insulin sensitivity in diabetes and inflammatory states.	Curcumin	32-40	insulin	Homo sapiens	53-60
16299251-6	2005	Surprisingly, 15-deoxy-Delta12,14-prostaglandin J(2) and the IkappaB kinase inhibitor curcumin both reduced nuclear levels of p65 in cell lines lacking IkappaBalpha, suggesting that inhibition of nuclear translocation of NF-kappaB can occur in the absence of IkappaBalpha.	Curcumin	86-94	NFKB inhibitor alpha	Homo sapiens	152-164
16299251-6	2005	Surprisingly, 15-deoxy-Delta12,14-prostaglandin J(2) and the IkappaB kinase inhibitor curcumin both reduced nuclear levels of p65 in cell lines lacking IkappaBalpha, suggesting that inhibition of nuclear translocation of NF-kappaB can occur in the absence of IkappaBalpha.	Curcumin	86-94	nuclear factor kappa B subunit 1	Homo sapiens	221-230
16299251-6	2005	Surprisingly, 15-deoxy-Delta12,14-prostaglandin J(2) and the IkappaB kinase inhibitor curcumin both reduced nuclear levels of p65 in cell lines lacking IkappaBalpha, suggesting that inhibition of nuclear translocation of NF-kappaB can occur in the absence of IkappaBalpha.	Curcumin	86-94	NFKB inhibitor alpha	Homo sapiens	259-271
16358608-10	2005	Curcumin (AP-1 inhibitor) markedly suppressed the TNF-alpha-induced CCL2 expression.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	50-59
16309195-0	2005	Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression, by curcumin and its analog, alpha-diisoeugenol.	Curcumin	95-103	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-74
16199533-5	2005	Curcumin and activator protein-1 (AP-1) decoy oligonucleotides abrogated both HP-induced HARP expression and LNCaP cell proliferation and migration.	Curcumin	0-8	pleiotrophin	Homo sapiens	89-93
16320828-0	2005	Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study.	Curcumin	0-8	caspase 3	Homo sapiens	139-148
16320828-4	2005	To test the hypothesis that curcumin also protects chondrocytes from morphological alterations induced by IL-1beta, we investigated its in vitro effects on apoptotic signalling proteins and key cartilage-specific matrix components in IL-1beta-stimulated chondrocytes.	Curcumin	28-36	interleukin 1 beta	Homo sapiens	106-114
16320828-8	2005	Transmission electron microscopy of chondrocytes stimulated with IL-1beta revealed early degenerative changes which were relieved by curcumin co-treatment.	Curcumin	133-141	interleukin 1 beta	Homo sapiens	65-73
16320828-9	2005	The suppression of collagen type II and beta1-integrin synthesis by IL-1beta was inhibited by curcumin.	Curcumin	94-102	interleukin 1 beta	Homo sapiens	68-76
16320828-10	2005	Additionally, curcumin antagonized IL-1beta-induced caspase-3 activation in a time-dependent manner.	Curcumin	14-22	interleukin 1 beta	Homo sapiens	35-43
16320828-10	2005	Additionally, curcumin antagonized IL-1beta-induced caspase-3 activation in a time-dependent manner.	Curcumin	14-22	caspase 3	Homo sapiens	52-61
16320828-11	2005	This study clearly demonstrates that curcumin exerts anti-apoptotic and anti-catabolic effects on IL-1beta-stimulated articular chondrocytes.	Curcumin	37-45	interleukin 1 beta	Homo sapiens	98-106
16356124-0	2005	Curcumin inhibits phorbol ester-induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	117-123
16356124-0	2005	Curcumin inhibits phorbol ester-induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	144-153
16356124-2	2005	In the present study, we investigated the possible inhibitory effects of curcumin on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in MCF10A human breast epithelial (MCF10A) cells and the underlying mechanisms.	Curcumin	73-81	prostaglandin-endoperoxide synthase 2	Homo sapiens	103-108
16356124-3	2005	Curcumin inhibited the TPA-induced COX-2 expression at both transcriptional and post-transcriptional levels, and reduced the synthesis of prostaglandin E(2), one of the major products of COX-2.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	35-40
16356124-3	2005	Curcumin inhibited the TPA-induced COX-2 expression at both transcriptional and post-transcriptional levels, and reduced the synthesis of prostaglandin E(2), one of the major products of COX-2.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	187-192
16356124-5	2005	Curcumin blocked TPA-induced activation of extracellular signal-regulated protein kinase (ERK1/2) and nuclear factor kappaB (NF-kappaB) transcriptional activity.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	90-96
16356124-5	2005	Curcumin blocked TPA-induced activation of extracellular signal-regulated protein kinase (ERK1/2) and nuclear factor kappaB (NF-kappaB) transcriptional activity.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	117-123
16356124-5	2005	Curcumin blocked TPA-induced activation of extracellular signal-regulated protein kinase (ERK1/2) and nuclear factor kappaB (NF-kappaB) transcriptional activity.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	125-134
16356124-8	2005	Taken together, these findings suggest that curcumin inhibits the TPA-induced up-regulation of COX-2 and MMP-9 by suppressing ERK1/2 phosphorylation and NF-kappaB trans-activation in human breast epithelial cells, which may contribute to its chemopreventive potential.	Curcumin	44-52	prostaglandin-endoperoxide synthase 2	Homo sapiens	95-100
16356124-8	2005	Taken together, these findings suggest that curcumin inhibits the TPA-induced up-regulation of COX-2 and MMP-9 by suppressing ERK1/2 phosphorylation and NF-kappaB trans-activation in human breast epithelial cells, which may contribute to its chemopreventive potential.	Curcumin	44-52	mitogen-activated protein kinase 3	Homo sapiens	126-132
16356124-8	2005	Taken together, these findings suggest that curcumin inhibits the TPA-induced up-regulation of COX-2 and MMP-9 by suppressing ERK1/2 phosphorylation and NF-kappaB trans-activation in human breast epithelial cells, which may contribute to its chemopreventive potential.	Curcumin	44-52	nuclear factor kappa B subunit 1	Homo sapiens	153-162
15987718-0	2005	Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5).	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	77-82
16276182-0	2005	Proapoptotic effect of curcumin on human neutrophils: activation of the p38 mitogen-activated protein kinase pathway.	Curcumin	23-31	mitogen-activated protein kinase 14	Homo sapiens	72-75
15987718-3	2005	In the present study, we show that subtoxic concentrations of curcumin sensitize human renal cancer cells to the tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis.	Curcumin	62-70	TNF superfamily member 10	Homo sapiens	113-168
15987718-3	2005	In the present study, we show that subtoxic concentrations of curcumin sensitize human renal cancer cells to the tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis.	Curcumin	62-70	TNF superfamily member 10	Homo sapiens	170-175
15987718-6	2005	Not only the pretreatment with N-acetylcystine but also the ectopic expression of peroxiredoxin II, an antioxidative protein, dramatically inhibited the apoptosis induced by curcumin and TRAIL in combination, blocking the curcumin-mediated DR5 upregulation.	Curcumin	222-230	TNF superfamily member 10	Homo sapiens	187-192
15987718-7	2005	Taken together, the present study demonstrates that curcumin enhances TRAIL-induced apoptosis by ROS-mediated DR5 upregulation.	Curcumin	52-60	TNF superfamily member 10	Homo sapiens	70-75
16276182-15	2005	Neutrophil activation was reduced by curcumin treatment as evidenced by a decrease in migration and myeloperoxidase release.	Curcumin	37-45	myeloperoxidase	Homo sapiens	100-115
16276182-16	2005	A marked increase in p38 phosphorylation and caspase-3 activity was observed following curcumin exposure.	Curcumin	87-95	mitogen-activated protein kinase 14	Homo sapiens	21-24
16276182-16	2005	A marked increase in p38 phosphorylation and caspase-3 activity was observed following curcumin exposure.	Curcumin	87-95	caspase 3	Homo sapiens	45-54
16276182-17	2005	In addition, inhibition of p38 mitogen-activated protein kinase with SB203580 suppressed apoptosis and caspase-3 activation induced by curcumin.	Curcumin	135-143	mitogen-activated protein kinase 14	Homo sapiens	27-30
16276182-17	2005	In addition, inhibition of p38 mitogen-activated protein kinase with SB203580 suppressed apoptosis and caspase-3 activation induced by curcumin.	Curcumin	135-143	caspase 3	Homo sapiens	103-112
16276182-18	2005	Thus, activation of p38 mitogen-activated protein kinase or an increase in caspase-3 activity appears to contribute to the proapoptotic effect of human neutrophil apoptosis by curcumin.	Curcumin	176-184	mitogen-activated protein kinase 14	Homo sapiens	20-23
16276182-18	2005	Thus, activation of p38 mitogen-activated protein kinase or an increase in caspase-3 activity appears to contribute to the proapoptotic effect of human neutrophil apoptosis by curcumin.	Curcumin	176-184	caspase 3	Homo sapiens	75-84
16221204-0	2005	Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis through up-regulation of heme oxygenase 1.	Curcumin	0-8	Thy-1 cell surface antigen	Rattus norvegicus	33-38
16044161-3	2005	Such effects of curcumin appear to result from suppression of the constitutively active STAT3 through inhibition of Janus kinase 1 (JAK1).	Curcumin	16-24	signal transducer and activator of transcription 3	Homo sapiens	88-93
16081677-0	2005	Curcumin suppresses interleukin 1beta-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	20-37
16081677-3	2005	In this study and other reports, curcumin suppresses interleukin-1beta-induced formation of prostaglandin E(2) in a concentration-dependent manner.	Curcumin	33-41	interleukin 1 beta	Homo sapiens	53-70
16081677-4	2005	Interleukin-1beta-induced microsomal prostaglandin E synthase 1 (mPGES-1) and cyclooxygenase-2 were attenuated by curcumin at the protein and mRNA levels, but a more dramatic inhibition of mPGES-1 expression was observed at lower concentrations of curcumin in A549 human lung epithelial cells.	Curcumin	114-122	interleukin 1 beta	Homo sapiens	0-17
16081677-4	2005	Interleukin-1beta-induced microsomal prostaglandin E synthase 1 (mPGES-1) and cyclooxygenase-2 were attenuated by curcumin at the protein and mRNA levels, but a more dramatic inhibition of mPGES-1 expression was observed at lower concentrations of curcumin in A549 human lung epithelial cells.	Curcumin	114-122	prostaglandin-endoperoxide synthase 2	Homo sapiens	78-94
16081677-4	2005	Interleukin-1beta-induced microsomal prostaglandin E synthase 1 (mPGES-1) and cyclooxygenase-2 were attenuated by curcumin at the protein and mRNA levels, but a more dramatic inhibition of mPGES-1 expression was observed at lower concentrations of curcumin in A549 human lung epithelial cells.	Curcumin	248-256	interleukin 1 beta	Homo sapiens	0-17
16081677-9	2005	Curcumin inhibited IkappaBalpha phosphorylation and degradation and thus reduced the expression of mPGES-1.	Curcumin	0-8	NFKB inhibitor alpha	Homo sapiens	19-31
16081677-10	2005	Curcumin suppressed cytokine-induced mPGES-1 by inhibiting phosphorylation of Jun N-terminal kinase (JNK)1/2.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	78-108
16081677-12	2005	These results indicate that curcumin inhibits IL-1beta-induced PGE(2) formation by inhibiting the expression of mPGES-1 that is mediated by suppression of EGR-1 expression as well as NF-kappaB and JNK1/2.	Curcumin	28-36	interleukin 1 beta	Homo sapiens	46-54
16081677-12	2005	These results indicate that curcumin inhibits IL-1beta-induced PGE(2) formation by inhibiting the expression of mPGES-1 that is mediated by suppression of EGR-1 expression as well as NF-kappaB and JNK1/2.	Curcumin	28-36	mitogen-activated protein kinase 8	Homo sapiens	197-203
16044161-5	2005	Altogether, our findings suggest a novel function for curcumin, acting as a suppressor of JAK-1 and STAT3 activation in PEL cells, leading to inhibition of proliferation and induction of caspase-dependent apoptosis.	Curcumin	54-62	signal transducer and activator of transcription 3	Homo sapiens	100-105
16044161-6	2005	Therefore, curcumin may have a future therapeutic role in PEL and possibly other malignancies with constitutive activation of STAT3.	Curcumin	11-19	signal transducer and activator of transcription 3	Homo sapiens	126-131
16221204-5	2005	The dose-dependent effect of curcumin on glomerular fibrosis was tested in the anti-Thy 1 glomerulonephritis model.	Curcumin	29-37	Thy-1 cell surface antigen	Rattus norvegicus	84-89
16044161-3	2005	Such effects of curcumin appear to result from suppression of the constitutively active STAT3 through inhibition of Janus kinase 1 (JAK1).	Curcumin	16-24	Janus kinase 1	Homo sapiens	116-130
16044161-3	2005	Such effects of curcumin appear to result from suppression of the constitutively active STAT3 through inhibition of Janus kinase 1 (JAK1).	Curcumin	16-24	Janus kinase 1	Homo sapiens	132-136
16044161-4	2005	Our data also demonstrate that curcumin induces loss of mitochondrial membrane potential with subsequent release of cytochrome c and activation of caspase-3, followed by polyadenosin-5"-diphosphate-ribose polymerase (PARP) cleavage.	Curcumin	31-39	cytochrome c, somatic	Homo sapiens	116-128
16044161-4	2005	Our data also demonstrate that curcumin induces loss of mitochondrial membrane potential with subsequent release of cytochrome c and activation of caspase-3, followed by polyadenosin-5"-diphosphate-ribose polymerase (PARP) cleavage.	Curcumin	31-39	caspase 3	Homo sapiens	147-156
16044161-4	2005	Our data also demonstrate that curcumin induces loss of mitochondrial membrane potential with subsequent release of cytochrome c and activation of caspase-3, followed by polyadenosin-5"-diphosphate-ribose polymerase (PARP) cleavage.	Curcumin	31-39	poly(ADP-ribose) polymerase 1	Homo sapiens	170-215
16044161-4	2005	Our data also demonstrate that curcumin induces loss of mitochondrial membrane potential with subsequent release of cytochrome c and activation of caspase-3, followed by polyadenosin-5"-diphosphate-ribose polymerase (PARP) cleavage.	Curcumin	31-39	poly(ADP-ribose) polymerase 1	Homo sapiens	217-221
16044161-5	2005	Altogether, our findings suggest a novel function for curcumin, acting as a suppressor of JAK-1 and STAT3 activation in PEL cells, leading to inhibition of proliferation and induction of caspase-dependent apoptosis.	Curcumin	54-62	Janus kinase 1	Homo sapiens	90-95
16243823-2	2005	Because curcumin suppresses nuclear factor-kappaB (NF-kappaB) activation and most chemotherapeutic agents activate NF-kappaB that mediates cell survival, proliferation, invasion, and metastasis, we hypothesized that curcumin would potentiate the effect of chemotherapy in advanced breast cancer and inhibit lung metastasis.	Curcumin	8-16	nuclear factor kappa B subunit 1	Homo sapiens	51-60
16243823-2	2005	Because curcumin suppresses nuclear factor-kappaB (NF-kappaB) activation and most chemotherapeutic agents activate NF-kappaB that mediates cell survival, proliferation, invasion, and metastasis, we hypothesized that curcumin would potentiate the effect of chemotherapy in advanced breast cancer and inhibit lung metastasis.	Curcumin	216-224	nuclear factor kappa B subunit 1	Homo sapiens	51-60
16243823-2	2005	Because curcumin suppresses nuclear factor-kappaB (NF-kappaB) activation and most chemotherapeutic agents activate NF-kappaB that mediates cell survival, proliferation, invasion, and metastasis, we hypothesized that curcumin would potentiate the effect of chemotherapy in advanced breast cancer and inhibit lung metastasis.	Curcumin	216-224	nuclear factor kappa B subunit 1	Homo sapiens	115-124
16243823-4	2005	As examined by electrophoretic mobility gel shift assay, paclitaxel activated NF-kappaB in breast cancer cells and curcumin inhibited it; this inhibition was mediated through inhibition of IkappaBalpha kinase activation and IkappaBalpha phosphorylation and degradation.	Curcumin	115-123	NFKB inhibitor alpha	Homo sapiens	189-201
16243823-4	2005	As examined by electrophoretic mobility gel shift assay, paclitaxel activated NF-kappaB in breast cancer cells and curcumin inhibited it; this inhibition was mediated through inhibition of IkappaBalpha kinase activation and IkappaBalpha phosphorylation and degradation.	Curcumin	115-123	NFKB inhibitor alpha	Homo sapiens	224-236
16243823-5	2005	Curcumin also suppressed the paclitaxel-induced expression of antiapoptotic (XIAP, IAP-1, IAP-2, Bcl-2, and Bcl-xL), proliferative (cyclooxygenase 2, c-Myc, and cyclin D1), and metastatic proteins (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1).	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	97-102
16243823-5	2005	Curcumin also suppressed the paclitaxel-induced expression of antiapoptotic (XIAP, IAP-1, IAP-2, Bcl-2, and Bcl-xL), proliferative (cyclooxygenase 2, c-Myc, and cyclin D1), and metastatic proteins (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1).	Curcumin	0-8	BCL2 like 1	Homo sapiens	108-114
16243823-5	2005	Curcumin also suppressed the paclitaxel-induced expression of antiapoptotic (XIAP, IAP-1, IAP-2, Bcl-2, and Bcl-xL), proliferative (cyclooxygenase 2, c-Myc, and cyclin D1), and metastatic proteins (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1).	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	132-148
16243823-7	2005	In a human breast cancer xenograft model, dietary administration of curcumin significantly decreased the incidence of breast cancer metastasis to the lung and suppressed the expression of NF-kappaB, cyclooxygenase 2, and matrix metalloproteinase-9.	Curcumin	68-76	nuclear factor kappa B subunit 1	Homo sapiens	188-197
16243823-7	2005	In a human breast cancer xenograft model, dietary administration of curcumin significantly decreased the incidence of breast cancer metastasis to the lung and suppressed the expression of NF-kappaB, cyclooxygenase 2, and matrix metalloproteinase-9.	Curcumin	68-76	prostaglandin-endoperoxide synthase 2	Homo sapiens	199-215
16243823-8	2005	Overall, our results indicate that curcumin, which is a pharmacologically safe compound, has a therapeutic potential in preventing breast cancer metastasis possibly through suppression of NF-kappaB and NF-kappaB-regulated gene products.	Curcumin	35-43	nuclear factor kappa B subunit 1	Homo sapiens	188-197
16243823-8	2005	Overall, our results indicate that curcumin, which is a pharmacologically safe compound, has a therapeutic potential in preventing breast cancer metastasis possibly through suppression of NF-kappaB and NF-kappaB-regulated gene products.	Curcumin	35-43	nuclear factor kappa B subunit 1	Homo sapiens	202-211
16102725-5	2005	The curcumin-mediated inhibition of MMP-9 gene expression appears to occur via NF-kappaB and AP-1 because their DNA binding activities were suppressed by curcumin.	Curcumin	4-12	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	93-97
16102725-5	2005	The curcumin-mediated inhibition of MMP-9 gene expression appears to occur via NF-kappaB and AP-1 because their DNA binding activities were suppressed by curcumin.	Curcumin	154-162	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	93-97
16102725-6	2005	Furthermore, curcumin strongly repressed the PMA-induced phosphorylation of ERK, JNK, and p38 MAP kinase, which were dependent on the PKC pathway.	Curcumin	13-21	mitogen-activated protein kinase 8	Homo sapiens	81-84
16102725-6	2005	Furthermore, curcumin strongly repressed the PMA-induced phosphorylation of ERK, JNK, and p38 MAP kinase, which were dependent on the PKC pathway.	Curcumin	13-21	mitogen-activated protein kinase 14	Homo sapiens	90-93
16173963-4	2005	In this study, we explored the effect and action mechanism of NF-kappaB inhibitors, BAY 11-7082 and curcumin, on NKTL cell lines (NKL, NK-92 and HANK1).	Curcumin	100-108	nuclear factor kappa B subunit 1	Homo sapiens	62-71
16507392-5	2005	In this study we investigated whether curcumin potentiates the growth inhibition effect of a COX-2 inhibitor (celecoxib, Pfizer, NY, USA) in human pancreatic cancer cells.	Curcumin	38-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	93-98
16507392-12	2005	CONCLUSION: Curcumin synergistically augments the growth inhibition inserted by celecoxib in pancreatic cancer cells expressing COX-2.	Curcumin	12-20	prostaglandin-endoperoxide synthase 2	Homo sapiens	128-133
16173963-6	2005	BAY 11-7082 and curcumin suppressed NF-kappaB activation in a time- and dose-dependent manner, which finally resulted in cell death.	Curcumin	16-24	nuclear factor kappa B subunit 1	Homo sapiens	36-45
16173963-7	2005	BAY 11-7082- and curcumin-induced cell death was associated with downregulation of Bcl-xL, cyclin D1, XIAP and c-FLIP, followed by caspase-8, poly(ADP-ribose) polymerase cleavage and activation.	Curcumin	17-25	BCL2 like 1	Homo sapiens	83-89
16173963-7	2005	BAY 11-7082- and curcumin-induced cell death was associated with downregulation of Bcl-xL, cyclin D1, XIAP and c-FLIP, followed by caspase-8, poly(ADP-ribose) polymerase cleavage and activation.	Curcumin	17-25	CASP8 and FADD like apoptosis regulator	Homo sapiens	111-117
16173963-7	2005	BAY 11-7082- and curcumin-induced cell death was associated with downregulation of Bcl-xL, cyclin D1, XIAP and c-FLIP, followed by caspase-8, poly(ADP-ribose) polymerase cleavage and activation.	Curcumin	17-25	poly(ADP-ribose) polymerase 1	Homo sapiens	142-169
16173963-8	2005	Given that the chemoresistant NK-92 cells respond to NF-kappaB inhibitors but not to conventional drugs, BAY 11-7082 and curcumin could be potentially useful for achieving improved outcome in chemotherapy-refractory NKTL.	Curcumin	121-129	nuclear factor kappa B subunit 1	Homo sapiens	53-62
15901641-6	2005	Curcumin (10(-8) M), which is known for inhibiting NFkappaB activation, inhibited IL1B-induced MIF secretion as well as NFkappaB nuclear translocation and DNA binding.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	51-59
16203793-5	2005	Curcumin treatment resulted in reduced nuclear expression of NF-kappabeta.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	61-73
16092118-2	2005	Curcumin (diferuloylmethane) is a phytochemical with potent NF-kappaB-inhibitory activity.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	60-69
16092118-2	2005	Curcumin (diferuloylmethane) is a phytochemical with potent NF-kappaB-inhibitory activity.	Curcumin	10-27	nuclear factor kappa B subunit 1	Homo sapiens	60-69
16092118-6	2005	NF-kappaB was constitutively active in all human pancreatic carcinoma cell lines evaluated and liposomal curcumin consistently suppressed NF-kappaB binding (electrophoretic mobility gel shift assay) and decreased the expression of NF-kappaB-regulated gene products, including cyclooxygenase-2 (immunoblots) and interleukin-8 (enzyme-linked immunoassay), both of which have been implicated in tumor growth/invasiveness.	Curcumin	105-113	nuclear factor kappa B subunit 1	Homo sapiens	138-147
16092118-6	2005	NF-kappaB was constitutively active in all human pancreatic carcinoma cell lines evaluated and liposomal curcumin consistently suppressed NF-kappaB binding (electrophoretic mobility gel shift assay) and decreased the expression of NF-kappaB-regulated gene products, including cyclooxygenase-2 (immunoblots) and interleukin-8 (enzyme-linked immunoassay), both of which have been implicated in tumor growth/invasiveness.	Curcumin	105-113	nuclear factor kappa B subunit 1	Homo sapiens	138-147
16092118-6	2005	NF-kappaB was constitutively active in all human pancreatic carcinoma cell lines evaluated and liposomal curcumin consistently suppressed NF-kappaB binding (electrophoretic mobility gel shift assay) and decreased the expression of NF-kappaB-regulated gene products, including cyclooxygenase-2 (immunoblots) and interleukin-8 (enzyme-linked immunoassay), both of which have been implicated in tumor growth/invasiveness.	Curcumin	105-113	prostaglandin-endoperoxide synthase 2	Homo sapiens	276-292
16092118-6	2005	NF-kappaB was constitutively active in all human pancreatic carcinoma cell lines evaluated and liposomal curcumin consistently suppressed NF-kappaB binding (electrophoretic mobility gel shift assay) and decreased the expression of NF-kappaB-regulated gene products, including cyclooxygenase-2 (immunoblots) and interleukin-8 (enzyme-linked immunoassay), both of which have been implicated in tumor growth/invasiveness.	Curcumin	105-113	C-X-C motif chemokine ligand 8	Homo sapiens	311-324
16092118-10	2005	CONCLUSIONS: Liposomal curcumin down-regulated the NF-kappaB machinery, suppressed growth, and induced apoptosis of human pancreatic cells in vitro.	Curcumin	23-31	nuclear factor kappa B subunit 1	Homo sapiens	51-60
16166455-3	2005	This study aims to investigate whether curcumin potentiates the growth inhibitory effect of celecoxib, a specific COX-2 inhibitor, in human colon cancer cells.	Curcumin	39-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	114-119
16023083-6	2005	On treatment of cells with curcumin, however, downregulated constitutive active NF-kappaB and inhibited the consitutively active IkappaBalpha kinase (IKK), and phosphorylation of IkappaBalpha and p65.	Curcumin	27-35	NFKB inhibitor alpha	Homo sapiens	129-141
16023083-6	2005	On treatment of cells with curcumin, however, downregulated constitutive active NF-kappaB and inhibited the consitutively active IkappaBalpha kinase (IKK), and phosphorylation of IkappaBalpha and p65.	Curcumin	27-35	NFKB inhibitor alpha	Homo sapiens	179-191
16023083-7	2005	Curcumin also inhibited constitutive activation of Akt, needed for IKK activation.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	51-54
15901641-6	2005	Curcumin (10(-8) M), which is known for inhibiting NFkappaB activation, inhibited IL1B-induced MIF secretion as well as NFkappaB nuclear translocation and DNA binding.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	82-86
15901641-6	2005	Curcumin (10(-8) M), which is known for inhibiting NFkappaB activation, inhibited IL1B-induced MIF secretion as well as NFkappaB nuclear translocation and DNA binding.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	120-128
16044419-7	2005	However, when NF-kappaB DNA binding activity was blocked by chemical (curcumin, PDTC, or salicylic acid) or biological inhibitors (NIK-KM or IKK-beta DN), the cell viability was less in SiHa cells with cisplatin treatment, but these effects were not observed in HeLa cells.	Curcumin	70-78	nuclear factor kappa B subunit 1	Homo sapiens	14-23
16193380-4	2005	Recently, curcumin, the major constituent of turmeric, was reported to inhibit NF-kappaB activity.	Curcumin	10-18	nuclear factor kappa B subunit 1	Homo sapiens	79-88
16193380-6	2005	Alteration of NF-kappaB activity in NP-2 human malignant astrocytoma cell line after treatment with curcumin was examined using electrophoretic mobility shift assay.	Curcumin	100-108	nuclear factor kappa B subunit 1	Homo sapiens	14-23
16193380-9	2005	We found that the NF-kappaB activity in NP-2 was significantly reduced by curcumin.	Curcumin	74-82	nuclear factor kappa B subunit 1	Homo sapiens	18-27
16193380-13	2005	These results are considered to be resulted from the inhibition of NF-kappaB activity by curcumin.	Curcumin	89-97	nuclear factor kappa B subunit 1	Homo sapiens	67-76
16342680-5	2005	Western blotting was used to detect expression of androgen receptor (AR) in LNCap cell with different concentrations of curcumin.	Curcumin	120-128	androgen receptor	Homo sapiens	50-67
16342680-5	2005	Western blotting was used to detect expression of androgen receptor (AR) in LNCap cell with different concentrations of curcumin.	Curcumin	120-128	androgen receptor	Homo sapiens	69-71
16342680-7	2005	There was also significant difference in AR expression as shown by Western blotting experiment after treatment of different doses of curcumin.	Curcumin	133-141	androgen receptor	Homo sapiens	41-43
16342680-8	2005	CONCLUSION: Through inhibiting AR expression, curcumin reduced the function of PSA promoter and inhibited PSA protein expression.	Curcumin	46-54	androgen receptor	Homo sapiens	31-33
16005433-0	2005	Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
16468334-0	2005	[Effects of curcumin on the acetylation of histone H3, P53 and the proliferation of NB4 cells].	Curcumin	12-20	tumor protein p53	Homo sapiens	55-58
16468334-1	2005	OBJECTIVE: To investigate the effects of curcumin on the acetylation of histone H3, P53 and the proliferation of NB4 cells.	Curcumin	41-49	tumor protein p53	Homo sapiens	84-87
16468334-7	2005	CONCLUSION: Curcumin functions as a deacetylase inhibitor,which could increase the level of acetylated histone H3, enhance the expression and activity of tumor suppressor P53, and inhibit the proliferation of NB4 cells.	Curcumin	12-20	tumor protein p53	Homo sapiens	171-174
16005433-3	2005	IFN-alpha induced NF-kappaB binding activity within 30 min and this increased binding activity was markedly suppressed with inclusion of curcumin.	Curcumin	137-145	interferon alpha 1	Homo sapiens	0-9
16005433-4	2005	Curcumin also inhibited IFN-alpha-induced COX-2 expression in A549 cells.	Curcumin	0-8	interferon alpha 1	Homo sapiens	24-33
16005433-4	2005	Curcumin also inhibited IFN-alpha-induced COX-2 expression in A549 cells.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47
16005433-5	2005	Within 10 min, IFN-alpha rapidly induced the binding activity of a gamma-(32)P-labeled consensus GAS oligonucleotide probe, which was profoundly reversed by curcumin.	Curcumin	157-165	interferon alpha 1	Homo sapiens	15-24
16005433-6	2005	Taken together, IFN-alpha-induced activations of NF-kappaB and COX-2 were inhibited by the addition of curcumin in A549 cells.	Curcumin	103-111	interferon alpha 1	Homo sapiens	16-25
16005433-6	2005	Taken together, IFN-alpha-induced activations of NF-kappaB and COX-2 were inhibited by the addition of curcumin in A549 cells.	Curcumin	103-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-68
16007726-0	2005	Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	276-279
16124875-3	2005	Both curcumin, a component of the spice turmeric, and N-acetylcysteine (NAC), an antioxidant, inhibit activation of NF-kappaB by inflammatory stimuli, albeit by different mechanisms.	Curcumin	5-13	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	116-125
16124875-4	2005	In the present study, we tested the hypothesis that dietary curcumin or NAC supplementation would inhibit unloading-induced NF-kappaB activity in skeletal muscle and thereby protect muscles against loss of mass and function caused by prolonged unloading.	Curcumin	60-68	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	124-133
16124875-10	2005	Curcumin supplementation decreased NF-kappaB activity measured in peripheral tissues of ambulatory mice by gel shift analysis.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	35-44
16002051-6	2005	The increased GSH content of differentiated U937 cells after pre-incubation with curcumin was associated with lowered ROS production, nuclear factor kappa B (NFkappaB) activation (-34%) and tumor necrosis factor alpha (TNF-alpha) secretion (-51%) after LPS exposure.	Curcumin	81-89	nuclear factor kappa B subunit 1	Homo sapiens	134-156
16002051-6	2005	The increased GSH content of differentiated U937 cells after pre-incubation with curcumin was associated with lowered ROS production, nuclear factor kappa B (NFkappaB) activation (-34%) and tumor necrosis factor alpha (TNF-alpha) secretion (-51%) after LPS exposure.	Curcumin	81-89	nuclear factor kappa B subunit 1	Homo sapiens	158-166
16002051-6	2005	The increased GSH content of differentiated U937 cells after pre-incubation with curcumin was associated with lowered ROS production, nuclear factor kappa B (NFkappaB) activation (-34%) and tumor necrosis factor alpha (TNF-alpha) secretion (-51%) after LPS exposure.	Curcumin	81-89	tumor necrosis factor	Homo sapiens	190-217
16007726-0	2005	Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway.	Curcumin	0-8	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	190-195
16007726-0	2005	Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	214-259
16002051-6	2005	The increased GSH content of differentiated U937 cells after pre-incubation with curcumin was associated with lowered ROS production, nuclear factor kappa B (NFkappaB) activation (-34%) and tumor necrosis factor alpha (TNF-alpha) secretion (-51%) after LPS exposure.	Curcumin	81-89	tumor necrosis factor	Homo sapiens	219-228
16007726-8	2005	Furthermore, in the presence of curcumin, the Akt inhibitor 1L-6-hydroxymethyl-chiro-inositol 2-[(R)-2-O-methyl-3-O-octadecylcarbonate] no longer suppressed Akt phosphorylation.	Curcumin	32-40	AKT serine/threonine kinase 1	Homo sapiens	46-49
16002051-7	2005	Curcumin inhibited TNF-alpha formation was also seen after GSH depletion by buthionine sulfoximine (BSO).	Curcumin	0-8	tumor necrosis factor	Homo sapiens	19-28
16007726-8	2005	Furthermore, in the presence of curcumin, the Akt inhibitor 1L-6-hydroxymethyl-chiro-inositol 2-[(R)-2-O-methyl-3-O-octadecylcarbonate] no longer suppressed Akt phosphorylation.	Curcumin	32-40	AKT serine/threonine kinase 1	Homo sapiens	157-160
16132679-5	2005	The addition of curcumin, nicotinamide and Jun N-terminal kinase (JNK) inhibitor, SP 600125, reduced the levels of NO, iNOS expression and nitration of proteins in macrophages.	Curcumin	16-24	nitric oxide synthase 2, inducible	Mus musculus	119-123
16083495-1	2005	BACKGROUND: Inhibition of the COP9 signalosome (CSN) associated kinases CK2 and PKD by curcumin causes stabilization of the tumor suppressor p53.	Curcumin	87-95	tumor protein p53	Homo sapiens	141-144
16038636-10	2005	P-gp was overexpressed in SGC7901/VCR cells, whereas it was downregulated after a 24-h treatment with curcumin (10 micromol/L).	Curcumin	102-110	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
16038636-11	2005	Resistant cells treated with 1 mumol/L VCR alone showed 77% lower levels of caspase-3 activation relative to SGC7901 cells, but the activation of caspase-3 in the resistant cell line increased by 44% when cells were treated with VCR in combination with curcumin.	Curcumin	253-261	caspase 3	Homo sapiens	146-155
16153429-11	2005	Furthermore, curcumin (5 and 10 microM) in combination with CRP (10 microg/mL) significantly increased TM mRNA levels by 45 and 100%, respectively, and increased EPCR mRNA levels by 24 and 45%, respectively, compared with those in CRP-treated cells (P &lt; .05).	Curcumin	13-21	C-reactive protein	Homo sapiens	231-234
16153429-14	2005	Curcumin completely blocks CRP-induced downregulation of TM and EPCR in HCAECs.	Curcumin	0-8	C-reactive protein	Homo sapiens	27-30
16081580-10	2005	CONCLUSIONS: The mechanisms involved in growth inhibitory effects of Velcade on HNSCC cell lines include the NF-kappaB pathway, suggesting the possible therapeutic use of Velcade or other NF-kappaB pathway inhibitors (eg, curcumin).	Curcumin	222-230	nuclear factor kappa B subunit 1	Homo sapiens	109-118
16235987-0	2005	Effects of water-soluble antioxidants and MAPKK/MEK inhibitor on curcumin-induced apoptosis in HL-60 human leukemic cells.	Curcumin	65-73	mitogen-activated protein kinase kinase 7	Homo sapiens	48-51
16235987-8	2005	MAPKK/MEK inhibitor PD98059, enhanced curcumin-induced HL-60 apoptotic cell death.	Curcumin	38-46	mitogen-activated protein kinase kinase 7	Homo sapiens	6-9
15982617-9	2005	Curcumin, a specific inhibitor of JNK, also concentration-dependently reduced IL-17--induced IL-8 production, with a maximal decrease of 82+/-4% (n=8, p&lt;0.01).	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	34-37
15879598-6	2005	In this study we report that rat TrxR1 activity in Trx-dependent disulfide reduction was inhibited by curcumin.	Curcumin	102-110	thioredoxin 1	Rattus norvegicus	33-36
15982617-9	2005	Curcumin, a specific inhibitor of JNK, also concentration-dependently reduced IL-17--induced IL-8 production, with a maximal decrease of 82+/-4% (n=8, p&lt;0.01).	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
15893313-0	2005	The inhibitory mechanism of curcumin and its derivative against beta-catenin/Tcf signaling.	Curcumin	28-36	hepatocyte nuclear factor 4 alpha	Homo sapiens	77-80
15921770-7	2005	As shown by means of real-time RT-PCR, VIP stimulated VEGF mRNA expression: the effect was inhibited by 40% in the presence of curcumin (an inhibitor of AP-1 binding), and it was dependent on Ca(2+) since BAPTA/AM inhibited this VIP action by 43%.	Curcumin	127-135	vasoactive intestinal peptide	Homo sapiens	39-42
15921770-7	2005	As shown by means of real-time RT-PCR, VIP stimulated VEGF mRNA expression: the effect was inhibited by 40% in the presence of curcumin (an inhibitor of AP-1 binding), and it was dependent on Ca(2+) since BAPTA/AM inhibited this VIP action by 43%.	Curcumin	127-135	vascular endothelial growth factor A	Homo sapiens	54-58
15921770-8	2005	Similar observations were made on the effects of BAPTA/AM and curcumin on VIP stimulation of VEGF protein expression.	Curcumin	62-70	vasoactive intestinal peptide	Homo sapiens	74-77
15921770-8	2005	Similar observations were made on the effects of BAPTA/AM and curcumin on VIP stimulation of VEGF protein expression.	Curcumin	62-70	vascular endothelial growth factor A	Homo sapiens	93-97
15911101-7	2005	Curcumin determined early changes in COX-2 and c-myc mRNAs, which were down-regulated, and in livin mRNA, which was up-regulated.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
15911101-10	2005	The cytotoxic interactions between curcumin and these agents were accompanied by synergistic (in particular with cisplatin) or additive effects of decrease in the expression of different genes, including c-myc, Bcl-X(L), c-IAP-2, NAIP and XIAP.	Curcumin	35-43	BCL2 like 1	Homo sapiens	211-219
15911101-11	2005	However, the combinations attenuated also certain other influences on mRNA expression of the single agents, like, for example, the increases in Bcl-X(s) given by curcumin and doxorubicin.	Curcumin	162-170	BCL2 like 1	Homo sapiens	144-149
15944320-0	2005	Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	92-102
15944320-6	2005	Curcumin significantly suppressed CD80, CD86, and MHC class II expression, but not MHC class I expression, in the DC.	Curcumin	0-8	CD80 antigen	Mus musculus	34-38
15944320-6	2005	Curcumin significantly suppressed CD80, CD86, and MHC class II expression, but not MHC class I expression, in the DC.	Curcumin	0-8	CD86 antigen	Mus musculus	40-44
15944320-10	2005	In addition, the curcumin-treated DC showed an impaired induction of Th1 responses and a normal cell-mediated immune response.	Curcumin	17-25	negative elongation factor complex member C/D, Th1l	Mus musculus	69-72
15923610-3	2005	The functional significance of a putative ARE in the GI-GPx promoter was validated by transcriptional activation of reporter gene constructs upon exposure to electrophiles (tBHQ, SFN, and curcumin) or overexpression of Nrf2 and by reversal of these effects by mutation of the ARE in the promoter and by overexpressed Keap1.	Curcumin	188-196	kelch like ECH associated protein 1	Homo sapiens	317-322
15899841-3	2005	Degradation of ERalpha induced by the pure antagonist ICI 182,780 (ICI) was blocked by curcumin but not by LMB, indicating that in the presence of ICI, ERalpha is degraded by a nuclear fraction of the proteasome.	Curcumin	87-95	estrogen receptor 1	Homo sapiens	15-22
15899841-3	2005	Degradation of ERalpha induced by the pure antagonist ICI 182,780 (ICI) was blocked by curcumin but not by LMB, indicating that in the presence of ICI, ERalpha is degraded by a nuclear fraction of the proteasome.	Curcumin	87-95	estrogen receptor 1	Homo sapiens	152-159
15899841-4	2005	In addition, we observed that curcumin inhibited estradiol-induced phosphorylation of ERalpha.	Curcumin	30-38	estrogen receptor 1	Homo sapiens	86-93
15899841-5	2005	The use of three inhibitors of ERalpha degradation that target different steps of the estrogen response pathway (inhibition of the CSN-associated kinase, nuclear export, and proteasome) suggests that a phosphorylation event inhibited by curcumin is necessary for ERalpha binding to its cognate DNA target.	Curcumin	237-245	estrogen receptor 1	Homo sapiens	31-38
15899841-5	2005	The use of three inhibitors of ERalpha degradation that target different steps of the estrogen response pathway (inhibition of the CSN-associated kinase, nuclear export, and proteasome) suggests that a phosphorylation event inhibited by curcumin is necessary for ERalpha binding to its cognate DNA target.	Curcumin	237-245	estrogen receptor 1	Homo sapiens	263-270
15990684-8	2005	Curcumin also decreased the enzyme activities of serum AST and ALT, which were increased in HCD animals.	Curcumin	0-8	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	55-58
16000872-0	2005	Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	36-41
16000872-0	2005	Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets.	Curcumin	0-8	mitogen-activated protein kinase 14	Homo sapiens	122-125
16000872-0	2005	Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	141-144
16000872-3	2005	Recently, curcumin has been regarded as a promising anti-inflammatory agent due to its ability to inhibit COX-2 expression.	Curcumin	10-18	prostaglandin-endoperoxide synthase 2	Homo sapiens	106-111
16000872-4	2005	However, it remains largely unknown whether curcumin inhibits the UVB-induced COX-2 expression in HaCaT cells.	Curcumin	44-52	prostaglandin-endoperoxide synthase 2	Homo sapiens	78-83
16000872-5	2005	This study was undertaken to clarify the effect of curcumin on the expression of COX-2 in UVB- irradiated HaCaT cells and further determined the molecular mechanisms associated with this process.	Curcumin	51-59	prostaglandin-endoperoxide synthase 2	Homo sapiens	81-86
16000872-7	2005	Interestingly, treatment with curcumin strongly inhibited COX-2 mRNA and protein expressions in UVB-irradiated HaCaT cells.	Curcumin	30-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-63
16000872-8	2005	Notably, there was effective inhibition by curcumin on UVB-induced activations of p38 MAPK and JNK in HaCaT cells.	Curcumin	43-51	mitogen-activated protein kinase 14	Homo sapiens	82-85
16000872-8	2005	Notably, there was effective inhibition by curcumin on UVB-induced activations of p38 MAPK and JNK in HaCaT cells.	Curcumin	43-51	mitogen-activated protein kinase 8	Homo sapiens	95-98
16000872-10	2005	These results collectively suggest that curcumin may inhibit COX- 2 expression by suppressing p38 MAPK and JNK activities in UVB-irradiated HaCaT cells.	Curcumin	40-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-67
16000872-10	2005	These results collectively suggest that curcumin may inhibit COX- 2 expression by suppressing p38 MAPK and JNK activities in UVB-irradiated HaCaT cells.	Curcumin	40-48	mitogen-activated protein kinase 14	Homo sapiens	94-97
16000872-10	2005	These results collectively suggest that curcumin may inhibit COX- 2 expression by suppressing p38 MAPK and JNK activities in UVB-irradiated HaCaT cells.	Curcumin	40-48	mitogen-activated protein kinase 8	Homo sapiens	107-110
15934930-5	2005	Curcumin, an NF-kappaB inhibitor, and mutation of the NF-kappaB responsive element in the bcl-2 promoter, blocked butyrate-induced bcl-2 promoter activity.	Curcumin	0-8	B cell leukemia/lymphoma 2	Mus musculus	131-136
15738001-0	2005	Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner.	Curcumin	0-8	tumor protein p53	Homo sapiens	111-114
15738001-3	2005	In our search toward delineating the molecular mechanisms behind such differential activities of curcumin, we found that it selectively increases p53 expression at G(2) phase of carcinoma cells and releases cytochrome c from mitochondria, which is an essential requirement for apoptosis.	Curcumin	97-105	tumor protein p53	Homo sapiens	146-149
15738001-3	2005	In our search toward delineating the molecular mechanisms behind such differential activities of curcumin, we found that it selectively increases p53 expression at G(2) phase of carcinoma cells and releases cytochrome c from mitochondria, which is an essential requirement for apoptosis.	Curcumin	97-105	cytochrome c, somatic	Homo sapiens	207-219
15738001-4	2005	Further experiments using p53-null as well as dominant-negative and wild-type p53-transfected cells have established that curcumin induces apoptosis in carcinoma cells via a p53-dependent pathway.	Curcumin	122-130	tumor protein p53	Homo sapiens	26-29
15738001-4	2005	Further experiments using p53-null as well as dominant-negative and wild-type p53-transfected cells have established that curcumin induces apoptosis in carcinoma cells via a p53-dependent pathway.	Curcumin	122-130	tumor protein p53	Homo sapiens	78-81
15738001-4	2005	Further experiments using p53-null as well as dominant-negative and wild-type p53-transfected cells have established that curcumin induces apoptosis in carcinoma cells via a p53-dependent pathway.	Curcumin	122-130	tumor protein p53	Homo sapiens	78-81
15738001-5	2005	On the other hand, curcumin reversibly inhibits normal mammary epithelial cell cycle progression by down-regulating cyclin D1 expression and blocking its association with Cdk4/Cdk6 as well as by inhibiting phosphorylation and inactivation of retinoblastoma protein.	Curcumin	19-27	cyclin dependent kinase 6	Homo sapiens	176-180
15893313-1	2005	We investigated the inhibitory mechanism of curcumin and its derivative (CHC007) against beta-catenin/T-cell factor (Tcf) signaling in various cancer cell lines.	Curcumin	44-52	hepatocyte nuclear factor 4 alpha	Homo sapiens	89-115
15893313-1	2005	We investigated the inhibitory mechanism of curcumin and its derivative (CHC007) against beta-catenin/T-cell factor (Tcf) signaling in various cancer cell lines.	Curcumin	44-52	hepatocyte nuclear factor 4 alpha	Homo sapiens	117-120
15893313-2	2005	Curcumin is known to inhibit beta-catenin/Tcf transcriptional activity in HCT116 cells but not in SW620 cells.	Curcumin	0-8	hepatocyte nuclear factor 4 alpha	Homo sapiens	42-45
15893313-3	2005	To clarify the inhibitory effect of curcumin against beta-catenin/Tcf signaling, we tested several cancer cell lines.	Curcumin	36-44	hepatocyte nuclear factor 4 alpha	Homo sapiens	66-69
15893313-7	2005	In the present study, we demonstrate that curcumin and its derivative are excellent inhibitors of beta-catenin/Tcf signaling in all tested cancer cell lines and the reduced beta-catenin/Tcf transcriptional activity is due to the decreased nuclear beta-catenin and Tcf-4.	Curcumin	42-50	hepatocyte nuclear factor 4 alpha	Homo sapiens	111-114
15893313-7	2005	In the present study, we demonstrate that curcumin and its derivative are excellent inhibitors of beta-catenin/Tcf signaling in all tested cancer cell lines and the reduced beta-catenin/Tcf transcriptional activity is due to the decreased nuclear beta-catenin and Tcf-4.	Curcumin	42-50	hepatocyte nuclear factor 4 alpha	Homo sapiens	186-189
15965083-8	2005	The results demonstrate that curcumin significantly attenuates MG-induced ROS formation, and suggest that ROS triggers cytochrome c release, caspase activation, and subsequent apoptotic biochemical changes.	Curcumin	29-37	cytochrome c, somatic	Homo sapiens	119-131
15842781-7	2005	The expression levels of HDAC1, HDAC3, and HDAC8 proteins were downregulated following curcumin treatment in Raji cells, whereas Ac-histone H4 protein expression was upregulated after treatment with curcumin.	Curcumin	87-95	histone deacetylase 1	Homo sapiens	25-30
15842781-8	2005	CONCLUSION: Curcumin, as a new member of the histone deacetylase inhibitors, can inhibit the expression of class I HDACs (HDAC1, HDAC3, and HDAC8), and can increase the expression of Ac-histone H4 in Raji cells.	Curcumin	12-20	histone deacetylase 1	Homo sapiens	122-127
15965083-6	2005	We report that curcumin prevented MG-induced cell death and apoptotic biochemical changes such as mitochondrial release of cytochrome c, caspase-3 activation, and cleavage of PARP (poly [ADP-ribose] polymerase).	Curcumin	15-23	cytochrome c, somatic	Homo sapiens	123-135
15965083-6	2005	We report that curcumin prevented MG-induced cell death and apoptotic biochemical changes such as mitochondrial release of cytochrome c, caspase-3 activation, and cleavage of PARP (poly [ADP-ribose] polymerase).	Curcumin	15-23	caspase 3	Homo sapiens	137-146
15965083-6	2005	We report that curcumin prevented MG-induced cell death and apoptotic biochemical changes such as mitochondrial release of cytochrome c, caspase-3 activation, and cleavage of PARP (poly [ADP-ribose] polymerase).	Curcumin	15-23	poly(ADP-ribose) polymerase 1	Homo sapiens	175-179
15809436-0	2005	Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.	Curcumin	122-130	NAD(P)H quinone dehydrogenase 1	Homo sapiens	14-46
15965083-6	2005	We report that curcumin prevented MG-induced cell death and apoptotic biochemical changes such as mitochondrial release of cytochrome c, caspase-3 activation, and cleavage of PARP (poly [ADP-ribose] polymerase).	Curcumin	15-23	poly(ADP-ribose) polymerase 1	Homo sapiens	181-209
15809436-3	2005	Here, we show that curcumin, a natural phenolic compound found in the spice turmeric, induced ubiquitin-independent degradation of WT p53 and inhibited p53-induced apoptosis in normal thymocytes and myeloid leukemic cells.	Curcumin	19-27	tumor protein p53	Homo sapiens	134-137
15809436-3	2005	Here, we show that curcumin, a natural phenolic compound found in the spice turmeric, induced ubiquitin-independent degradation of WT p53 and inhibited p53-induced apoptosis in normal thymocytes and myeloid leukemic cells.	Curcumin	19-27	tumor protein p53	Homo sapiens	152-155
15809436-0	2005	Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.	Curcumin	122-130	tumor protein p53	Homo sapiens	73-76
15809436-4	2005	Like dicoumarol, curcumin inhibited the activity of recombinant NQO1 in vitro, inhibited the activity of endogenous cellular NQO1 in vivo, and dissociated NQO1-WT p53 complexes.	Curcumin	17-25	NAD(P)H quinone dehydrogenase 1	Homo sapiens	64-68
15809436-4	2005	Like dicoumarol, curcumin inhibited the activity of recombinant NQO1 in vitro, inhibited the activity of endogenous cellular NQO1 in vivo, and dissociated NQO1-WT p53 complexes.	Curcumin	17-25	NAD(P)H quinone dehydrogenase 1	Homo sapiens	125-129
15809436-4	2005	Like dicoumarol, curcumin inhibited the activity of recombinant NQO1 in vitro, inhibited the activity of endogenous cellular NQO1 in vivo, and dissociated NQO1-WT p53 complexes.	Curcumin	17-25	NAD(P)H quinone dehydrogenase 1	Homo sapiens	125-129
15809436-4	2005	Like dicoumarol, curcumin inhibited the activity of recombinant NQO1 in vitro, inhibited the activity of endogenous cellular NQO1 in vivo, and dissociated NQO1-WT p53 complexes.	Curcumin	17-25	tumor protein p53	Homo sapiens	163-166
15809436-7	2005	The results indicate that curcumin induces p53 degradation and inhibits p53-induced apoptosis by an NQO1-dependent pathway.	Curcumin	26-34	tumor protein p53	Homo sapiens	43-46
15661804-0	2005	Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL.	Curcumin	44-52	BCL2 associated X, apoptosis regulator	Homo sapiens	33-36
15809436-7	2005	The results indicate that curcumin induces p53 degradation and inhibits p53-induced apoptosis by an NQO1-dependent pathway.	Curcumin	26-34	tumor protein p53	Homo sapiens	72-75
15809436-7	2005	The results indicate that curcumin induces p53 degradation and inhibits p53-induced apoptosis by an NQO1-dependent pathway.	Curcumin	26-34	NAD(P)H quinone dehydrogenase 1	Homo sapiens	100-104
15661804-5	2005	In Bax-/- cells curcumin-induced activation of caspases 9 and 3 was blocked and that of caspase 8 remained unaltered.	Curcumin	16-24	BCL2 associated X, apoptosis regulator	Homo sapiens	3-6
15661804-4	2005	Cell viability decreased in a concentration-dependent manner in Bax+/- cells treated with curcumin (0-50 microM) whereas only minimal changes in viability were observed in Bax-/- cells upon curcumin treatment.	Curcumin	90-98	BCL2 associated X, apoptosis regulator	Homo sapiens	64-67
15661804-6	2005	Curcumin-induced release of cytochrome c, Second mitochondria derived activator of caspase (Smac) and apoptosis inducing factor (AIF) was also blocked in Bax-/- cells and reintroduction of Bax, downregulation of the antiapoptotic protein Bcl-XL by antisense DNA as well as the overexpression of Smac, highly sensitized the Bax-/- cells toward curcumin-induced apoptosis.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	28-40
15661804-6	2005	Curcumin-induced release of cytochrome c, Second mitochondria derived activator of caspase (Smac) and apoptosis inducing factor (AIF) was also blocked in Bax-/- cells and reintroduction of Bax, downregulation of the antiapoptotic protein Bcl-XL by antisense DNA as well as the overexpression of Smac, highly sensitized the Bax-/- cells toward curcumin-induced apoptosis.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	154-157
15486348-8	2005	In addition, curcumin blocked EGF signaling by inhibiting EGF receptor (EGFR) tyrosine phosphorylation and suppressing the gene expression of EGFR mediated by activation of PPARgamma.	Curcumin	13-21	epidermal growth factor receptor	Homo sapiens	142-146
15661804-6	2005	Curcumin-induced release of cytochrome c, Second mitochondria derived activator of caspase (Smac) and apoptosis inducing factor (AIF) was also blocked in Bax-/- cells and reintroduction of Bax, downregulation of the antiapoptotic protein Bcl-XL by antisense DNA as well as the overexpression of Smac, highly sensitized the Bax-/- cells toward curcumin-induced apoptosis.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	189-192
15661804-6	2005	Curcumin-induced release of cytochrome c, Second mitochondria derived activator of caspase (Smac) and apoptosis inducing factor (AIF) was also blocked in Bax-/- cells and reintroduction of Bax, downregulation of the antiapoptotic protein Bcl-XL by antisense DNA as well as the overexpression of Smac, highly sensitized the Bax-/- cells toward curcumin-induced apoptosis.	Curcumin	0-8	BCL2 like 1	Homo sapiens	238-244
15661804-6	2005	Curcumin-induced release of cytochrome c, Second mitochondria derived activator of caspase (Smac) and apoptosis inducing factor (AIF) was also blocked in Bax-/- cells and reintroduction of Bax, downregulation of the antiapoptotic protein Bcl-XL by antisense DNA as well as the overexpression of Smac, highly sensitized the Bax-/- cells toward curcumin-induced apoptosis.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	189-192
15661804-6	2005	Curcumin-induced release of cytochrome c, Second mitochondria derived activator of caspase (Smac) and apoptosis inducing factor (AIF) was also blocked in Bax-/- cells and reintroduction of Bax, downregulation of the antiapoptotic protein Bcl-XL by antisense DNA as well as the overexpression of Smac, highly sensitized the Bax-/- cells toward curcumin-induced apoptosis.	Curcumin	343-351	cytochrome c, somatic	Homo sapiens	28-40
15661804-6	2005	Curcumin-induced release of cytochrome c, Second mitochondria derived activator of caspase (Smac) and apoptosis inducing factor (AIF) was also blocked in Bax-/- cells and reintroduction of Bax, downregulation of the antiapoptotic protein Bcl-XL by antisense DNA as well as the overexpression of Smac, highly sensitized the Bax-/- cells toward curcumin-induced apoptosis.	Curcumin	343-351	BCL2 associated X, apoptosis regulator	Homo sapiens	154-157
15661804-8	2005	The present study demonstrates the role of Bax but not Bak as a critical regulator of curcumin-induced apoptosis and implies the potential of targeting antiapoptotic proteins like Bcl-XL or overexpression of proapoptotic proteins like Smac as interventional approaches to deal with Bax-deficient chemo-resistant cancers for curcumin-based therapy.	Curcumin	86-94	BCL2 associated X, apoptosis regulator	Homo sapiens	43-46
15661804-8	2005	The present study demonstrates the role of Bax but not Bak as a critical regulator of curcumin-induced apoptosis and implies the potential of targeting antiapoptotic proteins like Bcl-XL or overexpression of proapoptotic proteins like Smac as interventional approaches to deal with Bax-deficient chemo-resistant cancers for curcumin-based therapy.	Curcumin	86-94	BCL2 associated X, apoptosis regulator	Homo sapiens	282-285
15661804-8	2005	The present study demonstrates the role of Bax but not Bak as a critical regulator of curcumin-induced apoptosis and implies the potential of targeting antiapoptotic proteins like Bcl-XL or overexpression of proapoptotic proteins like Smac as interventional approaches to deal with Bax-deficient chemo-resistant cancers for curcumin-based therapy.	Curcumin	324-332	BCL2 associated X, apoptosis regulator	Homo sapiens	43-46
15486348-0	2005	Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR.	Curcumin	29-37	peroxisome proliferator activated receptor gamma	Homo sapiens	14-24
15486348-0	2005	Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR.	Curcumin	29-37	epidermal growth factor receptor	Homo sapiens	126-130
15486348-5	2005	In the present report, we observed that curcumin, in a dose-dependent manner, inhibited the growth of Moser cells, a human colon cancer-derived cell line, and stimulated the trans-activating activity of PPARgamma.	Curcumin	40-48	peroxisome proliferator activated receptor gamma	Homo sapiens	203-212
15486348-6	2005	Further studies demonstrated that activation of PPARgamma was required for curcumin to inhibit Moser cell growth.	Curcumin	75-83	peroxisome proliferator activated receptor gamma	Homo sapiens	48-57
15486348-7	2005	Activation of PPARgamma mediated curcumin suppression of the expression of cyclin D1, a critical protein in the cell cycle, in Moser cells.	Curcumin	33-41	peroxisome proliferator activated receptor gamma	Homo sapiens	14-23
15486348-8	2005	In addition, curcumin blocked EGF signaling by inhibiting EGF receptor (EGFR) tyrosine phosphorylation and suppressing the gene expression of EGFR mediated by activation of PPARgamma.	Curcumin	13-21	epidermal growth factor receptor	Homo sapiens	58-70
15486348-8	2005	In addition, curcumin blocked EGF signaling by inhibiting EGF receptor (EGFR) tyrosine phosphorylation and suppressing the gene expression of EGFR mediated by activation of PPARgamma.	Curcumin	13-21	epidermal growth factor receptor	Homo sapiens	72-76
15733153-11	2005	In addition, NS-398, dexamethasone, OTZ, herbimycin A, and curcumin were found to inhibit the nicotine-induced ERK expression (p&lt;0.05).	Curcumin	59-67	mitogen-activated protein kinase 1	Homo sapiens	111-114
15733153-13	2005	In addition, nicotine-induced ERK expression was down-regulated by NS-398, dexamethasone, OTZ, herbimycin A, and curcumin.	Curcumin	113-121	mitogen-activated protein kinase 1	Homo sapiens	30-33
15486348-8	2005	In addition, curcumin blocked EGF signaling by inhibiting EGF receptor (EGFR) tyrosine phosphorylation and suppressing the gene expression of EGFR mediated by activation of PPARgamma.	Curcumin	13-21	peroxisome proliferator activated receptor gamma	Homo sapiens	173-182
15486348-9	2005	In addition to curcumin reduction of the level of phosphorylated PPARgamma, inhibition of cyclin D1 expression played a major and significant role in curcumin stimulation of PPARgamma activity in Moser cells.	Curcumin	15-23	peroxisome proliferator activated receptor gamma	Homo sapiens	65-74
15486348-9	2005	In addition to curcumin reduction of the level of phosphorylated PPARgamma, inhibition of cyclin D1 expression played a major and significant role in curcumin stimulation of PPARgamma activity in Moser cells.	Curcumin	150-158	peroxisome proliferator activated receptor gamma	Homo sapiens	174-183
15486348-10	2005	Taken together, our results demonstrated for the first time that curcumin activation of PPARgamma inhibited Moser cell growth and mediated the suppression of the gene expression of cyclin D1 and EGFR.	Curcumin	65-73	peroxisome proliferator activated receptor gamma	Homo sapiens	88-97
15486348-10	2005	Taken together, our results demonstrated for the first time that curcumin activation of PPARgamma inhibited Moser cell growth and mediated the suppression of the gene expression of cyclin D1 and EGFR.	Curcumin	65-73	epidermal growth factor receptor	Homo sapiens	195-199
15640282-11	2005	Signal transduction pathway inhibitors (SB203580, curcumin, and PD98059) implicated p38 and JNK, but not ERK, in 8-iso-PGF2alpha-induced suppression of monocyte adhesion.	Curcumin	50-58	mitogen-activated protein kinase 14	Homo sapiens	84-87
15640282-11	2005	Signal transduction pathway inhibitors (SB203580, curcumin, and PD98059) implicated p38 and JNK, but not ERK, in 8-iso-PGF2alpha-induced suppression of monocyte adhesion.	Curcumin	50-58	mitogen-activated protein kinase 8	Homo sapiens	92-95
15590651-0	2005	Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization.	Curcumin	44-52	nuclear factor kappa B subunit 1	Homo sapiens	81-102
15590651-0	2005	Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization.	Curcumin	44-52	AKT serine/threonine kinase 1	Homo sapiens	135-138
15590651-6	2005	Evaluation of signaling pathways common to Taxol and curcumin reveals that this synergism was in part related to down-regulation of NF-kappaB and serine/threonine kinase Akt pathways by curcumin.	Curcumin	53-61	nuclear factor kappa B subunit 1	Homo sapiens	132-141
15590651-6	2005	Evaluation of signaling pathways common to Taxol and curcumin reveals that this synergism was in part related to down-regulation of NF-kappaB and serine/threonine kinase Akt pathways by curcumin.	Curcumin	53-61	AKT serine/threonine kinase 1	Homo sapiens	170-173
15590651-6	2005	Evaluation of signaling pathways common to Taxol and curcumin reveals that this synergism was in part related to down-regulation of NF-kappaB and serine/threonine kinase Akt pathways by curcumin.	Curcumin	186-194	nuclear factor kappa B subunit 1	Homo sapiens	132-141
15590651-6	2005	Evaluation of signaling pathways common to Taxol and curcumin reveals that this synergism was in part related to down-regulation of NF-kappaB and serine/threonine kinase Akt pathways by curcumin.	Curcumin	186-194	AKT serine/threonine kinase 1	Homo sapiens	170-173
15590651-7	2005	An electrophoretic mobility shift assay revealed that activation of NF-kappaB induced by Taxol is down-regulated by curcumin.	Curcumin	116-124	nuclear factor kappa B subunit 1	Homo sapiens	68-77
15733321-0	2005	Astrocyte production of the chemokine macrophage inflammatory protein-2 is inhibited by the spice principle curcumin at the level of gene transcription.	Curcumin	108-116	chemokine (C-X-C motif) ligand 2	Mus musculus	38-71
15590651-8	2005	We also noted that curcumin-down-regulated Taxol induced phosphorylation of the serine/threonine kinase Akt, a survival signal which in many instances is regulated by NF-kappaB.	Curcumin	19-27	AKT serine/threonine kinase 1	Homo sapiens	104-107
15733321-2	2005	The origin of MIP-2 in inflammatory disorders of the brain has not been fully defined but astrocytes appear to be a dominant source of this chemokine.Curcumin is a spice principle in, and constitutes approximately 4 percent of, turmeric.	Curcumin	150-158	chemokine (C-X-C motif) ligand 2	Mus musculus	14-19
15733321-10	2005	RESULTS: The induction of MIP-2 gene expression and the production of MIP-2 protein were inhibited by curcumin.	Curcumin	102-110	chemokine (C-X-C motif) ligand 2	Mus musculus	26-31
15733321-10	2005	RESULTS: The induction of MIP-2 gene expression and the production of MIP-2 protein were inhibited by curcumin.	Curcumin	102-110	chemokine (C-X-C motif) ligand 2	Mus musculus	70-75
15590651-8	2005	We also noted that curcumin-down-regulated Taxol induced phosphorylation of the serine/threonine kinase Akt, a survival signal which in many instances is regulated by NF-kappaB.	Curcumin	19-27	nuclear factor kappa B subunit 1	Homo sapiens	167-176
15733321-11	2005	Curcumin also inhibited lipopolysaccharide-induced transcription of the MIP-2 promoter reporter gene construct in primary astrocytes.	Curcumin	0-8	chemokine (C-X-C motif) ligand 2	Mus musculus	72-77
15733321-13	2005	CONCLUSION: Our results indicate that curcumin potently inhibits MIP-2 production at the level of gene transcription and offer further support for its potential use in the treatment of inflammatory conditions of the CNS.	Curcumin	38-46	chemokine (C-X-C motif) ligand 2	Mus musculus	65-70
16237958-5	2005	We observed that curcumin inhibits PHA-induced T-cell proliferation, interleukin-2 production, NO generation, and lipopolysachharide-induced nuclear factor-kappaB (NF-kappaB) and augments NK cell cytotoxicity.	Curcumin	17-25	interleukin 2	Homo sapiens	69-82
15649425-6	2005	These results suggest that dietary phytochemicals, such as capsaicin, curcumin, [6]-gingerol, and resveratrol, have inhibitory effects on P-glycoprotein and potencies to cause drug-food interactions.	Curcumin	70-78	ATP binding cassette subfamily B member 1	Homo sapiens	138-152
15713005-8	2005	Also, curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone had PPAR-gamma ligand-binding activity.	Curcumin	6-14	peroxisome proliferator activated receptor gamma	Homo sapiens	78-88
15582996-0	2005	Curcumin stimulates cystic fibrosis transmembrane conductance regulator Cl- channel activity.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	20-71
15582996-2	2005	Previous studies suggested that the herbal extract curcumin might affect the processing of a common CF mutant, CFTR-DeltaF508.	Curcumin	51-59	CF transmembrane conductance regulator	Homo sapiens	111-115
15582996-4	2005	Curcumin increased CFTR channel activity in excised, inside-out membrane patches by reducing channel closed time and prolonging the time channels remained open.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	19-23
15582996-9	2005	These results suggest that curcumin may directly stimulate CFTR Cl(-) channels.	Curcumin	27-35	CF transmembrane conductance regulator	Homo sapiens	59-63
18095109-3	2005	In addition, we examined the in vitro effects of antisense oligonucleotides and curcumin on the expression and activation of RelA/NF-kappaB, urokinase-type plasminogen activator (u-PA) expression, migration, and invasion in the T98G glioma cell line.	Curcumin	80-88	nuclear factor kappa B subunit 1	Homo sapiens	130-139
18095109-6	2005	Moreover, antisense oligonucleotides and curcumin inhibited phorbol-12-myristate-13-acetate (PMA)-induced RelA/NF-kappaB expression or activation (or both), down-regulated u-PA expression, and reduced the migration and invasive potentials of T98G glioma cells.	Curcumin	41-49	nuclear factor kappa B subunit 1	Homo sapiens	111-120
18095109-6	2005	Moreover, antisense oligonucleotides and curcumin inhibited phorbol-12-myristate-13-acetate (PMA)-induced RelA/NF-kappaB expression or activation (or both), down-regulated u-PA expression, and reduced the migration and invasive potentials of T98G glioma cells.	Curcumin	41-49	plasminogen activator, urokinase	Homo sapiens	172-176
15733976-1	2005	The objective of this study was to elucidate the effects of tumor necrosis factor-alpha (TNF-alpha) on the expression of thrombomodulin (TM) and endothelial protein C receptor (EPCR) in human endothelial cells as well as the effect of curcumin, a spice and coloring food compound, as a potential therapeutic agent.	Curcumin	235-243	tumor necrosis factor	Homo sapiens	60-87
16471035-0	2005	Chemosensitization of hormone-refractory prostate cancer cells by curcumin to TRAIL-induced apoptosis.	Curcumin	66-74	TNF superfamily member 10	Homo sapiens	78-83
16471035-4	2005	We investigated the sensitization of prostate cancer cell lines by curcumin (diferuloyl-methane) to TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis.	Curcumin	67-75	TNF superfamily member 10	Homo sapiens	100-137
16471035-4	2005	We investigated the sensitization of prostate cancer cell lines by curcumin (diferuloyl-methane) to TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis.	Curcumin	67-75	TNF superfamily member 10	Homo sapiens	139-144
16471035-4	2005	We investigated the sensitization of prostate cancer cell lines by curcumin (diferuloyl-methane) to TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis.	Curcumin	77-95	TNF superfamily member 10	Homo sapiens	100-137
16471035-4	2005	We investigated the sensitization of prostate cancer cell lines by curcumin (diferuloyl-methane) to TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis.	Curcumin	77-95	TNF superfamily member 10	Homo sapiens	139-144
16471035-5	2005	Prostate cancer cells treated with curcumin or TRAIL or curcumin and TRAIL together were assessed for induction of apoptosis and pathway of apoptosis was determined from the activation of procaspases and release of cytochrome c from mitochondria.	Curcumin	35-43	cytochrome c, somatic	Homo sapiens	215-227
16471035-6	2005	Curcumin sensitized LNCaP, DU145 and PC3 tumor cell lines to TRAIL.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	61-66
16471035-7	2005	Combined curcumin and TRAIL treatment produced the most loss of viable cells by inducing apoptosis as revealed by accumulation of hypodiploid cells in sub-G1 phase, enhanced annexin V binding, DNA fragmentation, cleavage of procaspases-3, -8, and 9, truncation of proapoptotic Bid, and release of cytochrome c from mitochondria.	Curcumin	9-17	caspase 3	Homo sapiens	224-248
16471035-7	2005	Combined curcumin and TRAIL treatment produced the most loss of viable cells by inducing apoptosis as revealed by accumulation of hypodiploid cells in sub-G1 phase, enhanced annexin V binding, DNA fragmentation, cleavage of procaspases-3, -8, and 9, truncation of proapoptotic Bid, and release of cytochrome c from mitochondria.	Curcumin	9-17	BH3 interacting domain death agonist	Homo sapiens	277-280
16471035-7	2005	Combined curcumin and TRAIL treatment produced the most loss of viable cells by inducing apoptosis as revealed by accumulation of hypodiploid cells in sub-G1 phase, enhanced annexin V binding, DNA fragmentation, cleavage of procaspases-3, -8, and 9, truncation of proapoptotic Bid, and release of cytochrome c from mitochondria.	Curcumin	9-17	cytochrome c, somatic	Homo sapiens	297-309
16471035-8	2005	Tumor cells expressed constitutively active NF-kappaB and sensitization to TRAIL involved inhibition of NF-kappaB by curcumin.	Curcumin	117-125	TNF superfamily member 10	Homo sapiens	75-80
16416600-0	2005	Curcumin differentially sensitizes malignant glioma cells to TRAIL/Apo2L-mediated apoptosis through activation of procaspases and release of cytochrome c from mitochondria.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	61-66
16416600-0	2005	Curcumin differentially sensitizes malignant glioma cells to TRAIL/Apo2L-mediated apoptosis through activation of procaspases and release of cytochrome c from mitochondria.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	67-72
16416600-0	2005	Curcumin differentially sensitizes malignant glioma cells to TRAIL/Apo2L-mediated apoptosis through activation of procaspases and release of cytochrome c from mitochondria.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	141-153
16416600-4	2005	In the present study, we investigated whether curcumin sensitizes malignant glioma cell lines U251MG and U87MG to TRAIL-induced apoptosis.	Curcumin	46-54	TNF superfamily member 10	Homo sapiens	114-119
16416600-7	2005	Whereas curcumin at subtoxic concentration sensitized U87MG cells to TRAIL-induced cytotoxicity, it had no effect on TRAIL-mediated cytotoxicity in U251MG cells.	Curcumin	8-16	TNF superfamily member 10	Homo sapiens	69-74
16416600-8	2005	The combined curcumin and TRAIL treatment enhanced accumulation of hypo-diploid U87MG cells in sub G1 cell cycle phase and induced the cleavage of procaspases-3, -8, -9 and release of cytochrome c from mitochondria.	Curcumin	13-21	caspase 3	Homo sapiens	147-168
16416600-8	2005	The combined curcumin and TRAIL treatment enhanced accumulation of hypo-diploid U87MG cells in sub G1 cell cycle phase and induced the cleavage of procaspases-3, -8, -9 and release of cytochrome c from mitochondria.	Curcumin	13-21	cytochrome c, somatic	Homo sapiens	184-196
16416600-9	2005	These data indicate that curcumin differentially sensitizes glioma cells to TRAIL-induced apoptosis through the activation of both extrinsic (receptor-mediated) and intrinsic (chemical-induced) pathways of apoptosis.	Curcumin	25-33	TNF superfamily member 10	Homo sapiens	76-81
16416600-10	2005	These results define a potential use of curcumin to sensitize glioma cells for TRAIL-mediated immunotherapy.	Curcumin	40-48	TNF superfamily member 10	Homo sapiens	79-84
15733976-1	2005	The objective of this study was to elucidate the effects of tumor necrosis factor-alpha (TNF-alpha) on the expression of thrombomodulin (TM) and endothelial protein C receptor (EPCR) in human endothelial cells as well as the effect of curcumin, a spice and coloring food compound, as a potential therapeutic agent.	Curcumin	235-243	tumor necrosis factor	Homo sapiens	89-98
15733976-8	2005	Curcumin effectively blocked these effects of TNF-alpha on downregulation of TM and EPCR.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	46-55
15733976-10	2005	Curcumin can effectively block TNF-alpha-induced endothelial dysfunction.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	31-40
15383533-4	2004	In this study, we report that curcumin (diferuloylmethane), a major curcumanoid in the spice turmeric, is a specific inhibitor of the p300/CREB-binding protein (CBP) HAT activity but not of p300/CBP-associated factor, in vitro and in vivo.	Curcumin	30-38	CREB binding protein	Homo sapiens	161-164
15530432-5	2004	We tested this hypothesis by treating various cell lines expressing misprocessed mutants of CFTR or P-gp with thapsigargin or curcumin.	Curcumin	126-134	CF transmembrane conductance regulator	Homo sapiens	92-96
15383533-4	2004	In this study, we report that curcumin (diferuloylmethane), a major curcumanoid in the spice turmeric, is a specific inhibitor of the p300/CREB-binding protein (CBP) HAT activity but not of p300/CBP-associated factor, in vitro and in vivo.	Curcumin	30-38	CREB binding protein	Homo sapiens	195-198
15383533-4	2004	In this study, we report that curcumin (diferuloylmethane), a major curcumanoid in the spice turmeric, is a specific inhibitor of the p300/CREB-binding protein (CBP) HAT activity but not of p300/CBP-associated factor, in vitro and in vivo.	Curcumin	40-57	CREB binding protein	Homo sapiens	161-164
15383533-4	2004	In this study, we report that curcumin (diferuloylmethane), a major curcumanoid in the spice turmeric, is a specific inhibitor of the p300/CREB-binding protein (CBP) HAT activity but not of p300/CBP-associated factor, in vitro and in vivo.	Curcumin	40-57	CREB binding protein	Homo sapiens	195-198
15383533-5	2004	Furthermore, curcumin could also inhibit the p300-mediated acetylation of p53 in vivo.	Curcumin	13-21	tumor protein p53	Homo sapiens	74-77
15383533-8	2004	Thus, non-toxic curcumin, which targets p300/CBP, may serve as a lead compound in combinatorial HIV therapeutics.	Curcumin	16-24	CREB binding protein	Homo sapiens	45-48
15582125-0	2004	Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	18-27
15569404-8	2004	After removal of tBHP and then further treatment with curcumin (2.5-20 micromol/L) for 18 h, curcumin abrogated Deltapsim loss and cytochrome c release, blocked activation of caspase 3, and altered the expression of Bcl-2 family.	Curcumin	54-62	BCL2, apoptosis regulator	Rattus norvegicus	216-221
15569404-8	2004	After removal of tBHP and then further treatment with curcumin (2.5-20 micromol/L) for 18 h, curcumin abrogated Deltapsim loss and cytochrome c release, blocked activation of caspase 3, and altered the expression of Bcl-2 family.	Curcumin	93-101	BCL2, apoptosis regulator	Rattus norvegicus	216-221
15604057-5	2004	Curcumin and sulfasalazine obviously suppressed the high expression of proinflammatory cytokine interleukin (IL)-1beta mRNA and increased the low expression of IL-10 mRNA in the colonic mucosa.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	96-118
15604057-7	2004	CONCLUSIONS: Curcumin could modulate the expressions of IL-1beta and IL-10 mRNA in murine model of IBD, which suggests the potential of curcumin as a targeted therapeutic agent for IBD.	Curcumin	13-21	interleukin 1 beta	Mus musculus	56-64
15604057-7	2004	CONCLUSIONS: Curcumin could modulate the expressions of IL-1beta and IL-10 mRNA in murine model of IBD, which suggests the potential of curcumin as a targeted therapeutic agent for IBD.	Curcumin	13-21	interleukin 10	Mus musculus	69-74
15604057-7	2004	CONCLUSIONS: Curcumin could modulate the expressions of IL-1beta and IL-10 mRNA in murine model of IBD, which suggests the potential of curcumin as a targeted therapeutic agent for IBD.	Curcumin	136-144	interleukin 1 beta	Mus musculus	56-64
15604057-7	2004	CONCLUSIONS: Curcumin could modulate the expressions of IL-1beta and IL-10 mRNA in murine model of IBD, which suggests the potential of curcumin as a targeted therapeutic agent for IBD.	Curcumin	136-144	interleukin 10	Mus musculus	69-74
15659840-0	2004	Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes.	Curcumin	11-19	interleukin 1 beta	Homo sapiens	78-95
15659840-0	2004	Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes.	Curcumin	21-38	interleukin 1 beta	Homo sapiens	78-95
15659840-1	2004	Curcumin (diferuloylmethane) is a nontoxic dietary pigment in tumeric and curry and a potent inhibitor of the common transcription factor Nuclear Factor kappaB (NF-kappaB) in several cell types.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	161-170
15659840-1	2004	Curcumin (diferuloylmethane) is a nontoxic dietary pigment in tumeric and curry and a potent inhibitor of the common transcription factor Nuclear Factor kappaB (NF-kappaB) in several cell types.	Curcumin	10-27	nuclear factor kappa B subunit 1	Homo sapiens	161-170
15659840-3	2004	Therefore, the aim of this study was to determine whether curcumin modifies the catabolic response of chondrocytes to IL-1beta.	Curcumin	58-66	interleukin 1 beta	Homo sapiens	118-126
15659840-7	2004	Upregulation of MMP-3 was inhibited by curcumin in a time-dependent manner.	Curcumin	39-47	matrix metallopeptidase 3	Homo sapiens	16-21
15659840-8	2004	In addition, IL-1beta-induced a decrease in type II collagen, which was relieved by curcumin treatment.	Curcumin	84-92	interleukin 1 beta	Homo sapiens	13-21
15659840-9	2004	In response to IL-1beta, NF-kappaB translocated to the nucleus, but translocation was inhibited by curcumin, as revealed by immunofluorescence microscopy.	Curcumin	99-107	interleukin 1 beta	Homo sapiens	15-23
15659840-9	2004	In response to IL-1beta, NF-kappaB translocated to the nucleus, but translocation was inhibited by curcumin, as revealed by immunofluorescence microscopy.	Curcumin	99-107	nuclear factor kappa B subunit 1	Homo sapiens	25-34
15659840-11	2004	Curcumin protected chondrocytes from the catabolic effects of IL-1beta, such as MMP-3 upregulation, and interestingly also relieved cytokine-induced suppression of matrix protein synthesis.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	62-70
15659840-11	2004	Curcumin protected chondrocytes from the catabolic effects of IL-1beta, such as MMP-3 upregulation, and interestingly also relieved cytokine-induced suppression of matrix protein synthesis.	Curcumin	0-8	matrix metallopeptidase 3	Homo sapiens	80-85
15659840-12	2004	Therefore, curcumin antagonizes crucial catabolic effects of IL-1beta signaling that are known to contribute to the pathogenesis of osteoarthritis.	Curcumin	11-19	interleukin 1 beta	Homo sapiens	61-69
15582125-7	2004	Curcumin prevented the MCD-induced activation of NF-kappaB and decreased downstream induction of ICAM-1, COX-2 and MCP-1.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-58
15582125-7	2004	Curcumin prevented the MCD-induced activation of NF-kappaB and decreased downstream induction of ICAM-1, COX-2 and MCP-1.	Curcumin	0-8	mast cell protease 1	Mus musculus	115-120
15569263-6	2004	Curcumin abrogated Abeta1-40-induced expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in both peripheral blood monocytes and THP-1 cells.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	76-84
15470680-8	2004	The statistical relationship between PcG and NFkappaB activation was further explored in HL-derived cell lines treated with curcumin, an NFkappaB inhibitor, and TNFalpha.	Curcumin	124-132	nuclear factor kappa B subunit 1	Homo sapiens	45-53
15491342-15	2004	Our data also shows that EGF-stimulated uPA production involves the activation of the extracellular signal-regulated kinases 1/2 and JNK signaling pathways and might be modulated by the natural phytoestrogens curcumin and genistein.	Curcumin	209-217	plasminogen activator, urokinase	Homo sapiens	40-43
15491342-15	2004	Our data also shows that EGF-stimulated uPA production involves the activation of the extracellular signal-regulated kinases 1/2 and JNK signaling pathways and might be modulated by the natural phytoestrogens curcumin and genistein.	Curcumin	209-217	mitogen-activated protein kinase 8	Homo sapiens	86-136
15635257-6	2004	However, significant inhibition of radiation-induced ERK and NFkappaB was observed with both curcumin and nicotinamide.	Curcumin	93-101	mitogen-activated protein kinase 1	Mus musculus	53-56
15635257-6	2004	However, significant inhibition of radiation-induced ERK and NFkappaB was observed with both curcumin and nicotinamide.	Curcumin	93-101	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	61-69
15622377-11	2004	In addition, eNOS immunoreactivity was reduced in the homocysteine group, but the combined homocysteine and curcumin group showed eNOS levels comparable to those in the control group.	Curcumin	108-116	nitric oxide synthase 3	Homo sapiens	130-134
15622377-14	2004	In addition, curcumin significantly blocked homocysteine-induced superoxide anion production and eNOS down-regulation.	Curcumin	13-21	nitric oxide synthase 3	Homo sapiens	97-101
15569263-0	2004	Curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and CCR5-mediated chemotaxis of THP-1 monocytes by modulating early growth response-1 transcription factor.	Curcumin	0-8	GLI family zinc finger 2	Homo sapiens	141-146
15569263-5	2004	We show that curcumin (12.5-25 microm) suppresses the activation of Egr-1 DNA-binding activity in THP-1 monocytic cells.	Curcumin	13-21	GLI family zinc finger 2	Homo sapiens	98-103
15569263-6	2004	Curcumin abrogated Abeta1-40-induced expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in both peripheral blood monocytes and THP-1 cells.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	62-71
15569263-6	2004	Curcumin abrogated Abeta1-40-induced expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in both peripheral blood monocytes and THP-1 cells.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
15569263-6	2004	Curcumin abrogated Abeta1-40-induced expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in both peripheral blood monocytes and THP-1 cells.	Curcumin	0-8	GLI family zinc finger 2	Homo sapiens	168-173
15569263-7	2004	We found that curcumin inhibited Abeta1-40-induced MAP kinase activation and the phosphorylation of ERK-1/2 and its downstream target Elk-1.	Curcumin	14-22	mitogen-activated protein kinase 3	Homo sapiens	100-107
15569263-8	2004	We observed that curcumin inhibited Abeta1-40-induced expression of CCR5 but not of CCR2b in THP-1 cells.	Curcumin	17-25	GLI family zinc finger 2	Homo sapiens	93-98
15569263-10	2004	Finally, curcumin inhibited chemotaxis of THP-1 monocytes in response to chemoattractant.	Curcumin	9-17	GLI family zinc finger 2	Homo sapiens	42-47
15807244-9	2004	Observed with western blot method, with the increase of curcumin concentration to 10 micromol/L, the expression of PARP increased simultaneously.	Curcumin	56-64	poly(ADP-ribose) polymerase 1	Homo sapiens	115-119
15465643-3	2004	Addition of catalase protected DNA from the curcumin-dependent injuries, indicating that hydroxyl radical may participate in the DNA damage.	Curcumin	44-52	catalase	Homo sapiens	12-20
15476675-0	2004	Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder.	Curcumin	71-79	ATP binding cassette subfamily B member 1	Homo sapiens	45-59
15320868-0	2004	Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro.	Curcumin	40-48	peroxisome proliferator activated receptor gamma	Homo sapiens	14-23
15320868-6	2004	Further studies indicated that curcumin induced the gene expression of PPARgamma and stimulated its activity in activated HSC in vitro, which was required for curcumin to inhibit HSC proliferation.	Curcumin	31-39	peroxisome proliferator activated receptor gamma	Homo sapiens	71-80
15320868-6	2004	Further studies indicated that curcumin induced the gene expression of PPARgamma and stimulated its activity in activated HSC in vitro, which was required for curcumin to inhibit HSC proliferation.	Curcumin	159-167	peroxisome proliferator activated receptor gamma	Homo sapiens	71-80
15320868-7	2004	The aims of the present study were to evaluate the roles of PPARgamma activation in the induction of apoptosis and suppression of ECM gene expression by curcumin in activated HSC, and to elucidate the underlying mechanisms.	Curcumin	153-161	peroxisome proliferator activated receptor gamma	Homo sapiens	60-69
15320868-8	2004	Our results demonstrated that blocking PPARgamma activation abrogated the effects of curcumin on the induction of apoptosis and inhibition of the expression of ECM genes in activated HSC in vitro.	Curcumin	85-93	peroxisome proliferator activated receptor gamma	Homo sapiens	39-48
15320868-9	2004	Further experiments demonstrated that curcumin suppressed the gene expression of TGF-beta (transforming growth factor-beta) receptors and interrupted the TGF-beta signalling pathway in activated HSC, which was mediated by PPARgamma activation.	Curcumin	38-46	peroxisome proliferator activated receptor gamma	Homo sapiens	222-231
15320868-10	2004	Taken together, our results demonstrate that curcumin stimulated PPARgamma activity in activated HSC in vitro, which was required for curcumin to reduce cell proliferation, induce apoptosis and suppress ECM gene expression.	Curcumin	45-53	peroxisome proliferator activated receptor gamma	Homo sapiens	65-74
15476675-8	2004	The inhibitory effect in a concentration-dependent manner of curcuminoids on verapamil-stimulated ATPase activity and photoaffinity labeling of Pgp with the [(125)I]-iodoarylazidoprazosin offered additional support; curcumin I was the most potent modulator.	Curcumin	216-226	ATP binding cassette subfamily B member 1	Homo sapiens	144-147
15476675-0	2004	Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder.	Curcumin	71-79	ATP binding cassette subfamily B member 1	Homo sapiens	61-66
15320868-10	2004	Taken together, our results demonstrate that curcumin stimulated PPARgamma activity in activated HSC in vitro, which was required for curcumin to reduce cell proliferation, induce apoptosis and suppress ECM gene expression.	Curcumin	134-142	peroxisome proliferator activated receptor gamma	Homo sapiens	65-74
15476675-2	2004	Previously [Biochem Pharmacol 2002;64:573-82], we reported that a curcumin mixture could modulate both function and expression of Pgp.	Curcumin	66-74	ATP binding cassette subfamily B member 1	Homo sapiens	130-133
15476283-5	2004	Curcumin decreased the expression of NF-kappaB-regulated gene products, including cyclooxygenase-2 (as assessed using immunoblot analysis), prostaglandin E2, and interleukin-8 (as assessed using an enzyme-linked immunoassay), all of which have been implicated in the growth and invasiveness of pancreatic carcinoma.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	82-98
15476675-3	2004	This study focuses on the effect of three major curcuminoids--curcumin I, II and III purified from a curcumin mixture--on modulation of Pgp function in a multidrug resistant human cervical carcinoma cell line (KB-V1).	Curcumin	48-56	ATP binding cassette subfamily B member 1	Homo sapiens	136-139
15476283-5	2004	Curcumin decreased the expression of NF-kappaB-regulated gene products, including cyclooxygenase-2 (as assessed using immunoblot analysis), prostaglandin E2, and interleukin-8 (as assessed using an enzyme-linked immunoassay), all of which have been implicated in the growth and invasiveness of pancreatic carcinoma.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	162-175
15476675-3	2004	This study focuses on the effect of three major curcuminoids--curcumin I, II and III purified from a curcumin mixture--on modulation of Pgp function in a multidrug resistant human cervical carcinoma cell line (KB-V1).	Curcumin	62-70	ATP binding cassette subfamily B member 1	Homo sapiens	136-139
15358181-3	2004	After the AP-1 inhibition by curcumin analogs in TPA-treated HT-1080 human fibrosarcoma cells, a decrease in mRNA expression of c-jun and MMP3 (stromelysin-1) has been observed.	Curcumin	29-37	matrix metallopeptidase 3	Homo sapiens	138-142
15256484-10	2004	Taken together, our data show for the first time that JNK, but not p38 or ERK signalling, plays an important role in curcumin-mediated apoptosis in human colon cancer cells that may underlie its chemopreventive effects.	Curcumin	117-125	mitogen-activated protein kinase 8	Homo sapiens	54-57
15271854-0	2004	Curcumin-induced GADD153 gene up-regulation in human colon cancer cells.	Curcumin	0-8	DNA damage inducible transcript 3	Homo sapiens	17-24
15271854-5	2004	To identify a potential pro-apoptotic gene that could be responsive to the DNA damage in curcumin-treated cells, growth arrest and DNA damage-inducible gene 153 (GADD153) was considered.	Curcumin	89-97	DNA damage inducible transcript 3	Homo sapiens	113-160
15271854-5	2004	To identify a potential pro-apoptotic gene that could be responsive to the DNA damage in curcumin-treated cells, growth arrest and DNA damage-inducible gene 153 (GADD153) was considered.	Curcumin	89-97	DNA damage inducible transcript 3	Homo sapiens	162-169
15271854-6	2004	Curcumin increased GADD153 mRNA (and also protein) expression, which was prevented by actinomycin D and also by a broad protein kinase C inhibitor, but not by selective MAPK inhibitors.	Curcumin	0-8	DNA damage inducible transcript 3	Homo sapiens	19-26
15271854-7	2004	These findings suggest that curcumin-induced up-regulation of GADD153 mRNA expression was at the level of transcription, but apparently without depending on upstream MAPK.	Curcumin	28-36	DNA damage inducible transcript 3	Homo sapiens	62-69
15271854-8	2004	In determining the involvement of reactive oxygen species in mediating the effect of curcumin on GADD153, the antioxidants pyrrolidine dithiocarbamate and N-acetylcysteine (NAC), but neither alpha-tocopherol nor catalase, also blunted or prevented up-regulation of GADD153 mRNA expression caused by curcumin.	Curcumin	85-93	DNA damage inducible transcript 3	Homo sapiens	97-104
15271854-10	2004	Because expression of GADD153 protein was detected before the appearance of apoptotic features, this observation raises the possibility that GADD153 protein might be important for curcumin-induced apoptosis.	Curcumin	180-188	DNA damage inducible transcript 3	Homo sapiens	22-29
15271854-10	2004	Because expression of GADD153 protein was detected before the appearance of apoptotic features, this observation raises the possibility that GADD153 protein might be important for curcumin-induced apoptosis.	Curcumin	180-188	DNA damage inducible transcript 3	Homo sapiens	141-148
15451666-7	2004	The inhibitors of CSN associated kinases, curcumin and emodin, significantly induce ubiquitination and proteasome-dependent degradation of transiently expressed Id3 in HeLa cells.	Curcumin	42-50	inhibitor of DNA binding 3, HLH protein	Homo sapiens	161-164
15451666-10	2004	Curcumin increased Id3-ubiquitin conjugate formation, as shown by Western blotting and His-pull-downs.	Curcumin	0-8	inhibitor of DNA binding 3, HLH protein	Homo sapiens	19-22
15205359-0	2004	Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it.	Curcumin	87-95	BCL2 like 1	Homo sapiens	22-28
15205359-5	2004	Curcumin-induced cell death and nuclear condensation was more in AsBcl-XL and AsKu70 cells that under-express Bcl-XL and Ku70, respectively, compared with the vector-transfected cells.	Curcumin	0-8	BCL2 like 1	Homo sapiens	67-73
15205359-6	2004	Bcl-XL and Ku70 protected the cells by inhibiting the release of cytochrome c, Smac (second mitochondria derived activator of caspase) and apoptosis inducing factor (AIF), and the activation of caspases 9, 8 and 3 triggered by curcumin.	Curcumin	227-235	BCL2 like 1	Homo sapiens	0-6
15205359-7	2004	AsBcl-XL and AsKu70 cells were more sensitive to curcumin through enhanced activation of caspases 9 and 3 and release of cytochrome c, Smac and AIF.	Curcumin	49-57	cytochrome c, somatic	Homo sapiens	121-133
15501456-6	2004	In another parallel experiment we added IL-2 (0.5 nM) to stimulate the cells to check if Curcumin"s inhibition of IL-2 synthesis is the sole reason for inhibition of cell proliferation.	Curcumin	89-97	interleukin 2	Homo sapiens	114-118
15501456-9	2004	Curcumin inhibited IL-2 synthesis in Con A, PHA, and PMA stimulated SP-L in a concentration-dependent manner with an ED50 (concentration required for 50% inhibition) measured at 3.5 microg/ml.	Curcumin	0-8	interleukin 2	Homo sapiens	19-23
15501456-10	2004	Exogenous IL-2 stimulated SP-L proliferation was also inhibited by Curcumin in a concentration-dependent manner with an ED50 of 2 microg/ml.	Curcumin	67-75	interleukin 2	Homo sapiens	10-14
15501456-11	2004	EMSA assay indicated that PMA at 20 ng/ml stimulated NFkappaB activation 253% over control, which was inhibited by 24, 38, and 73%, respectively, with Curcumin at final concentrations of 2.5, 5, and 10 microg/ml, respectively.	Curcumin	151-159	nuclear factor kappa B subunit 1	Homo sapiens	53-61
15501456-12	2004	CONCLUSION: Curcumin has profound immunosuppressive effects mediated via inhibition of IL-2 synthesis, mitogen, and IL-2 induced activation of human lymphocytes.	Curcumin	12-20	interleukin 2	Homo sapiens	87-91
15501456-12	2004	CONCLUSION: Curcumin has profound immunosuppressive effects mediated via inhibition of IL-2 synthesis, mitogen, and IL-2 induced activation of human lymphocytes.	Curcumin	12-20	interleukin 2	Homo sapiens	116-120
15352173-6	2004	Curcumin, an anti-oxidant and JNK inhibitor, inhibited PF-induced apoptosis, suggesting the possible involvement of curcumin-sensitive JNK or other redox-sensitive elements in PF-induced apoptosis.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	30-33
15352173-6	2004	Curcumin, an anti-oxidant and JNK inhibitor, inhibited PF-induced apoptosis, suggesting the possible involvement of curcumin-sensitive JNK or other redox-sensitive elements in PF-induced apoptosis.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	135-138
15352173-6	2004	Curcumin, an anti-oxidant and JNK inhibitor, inhibited PF-induced apoptosis, suggesting the possible involvement of curcumin-sensitive JNK or other redox-sensitive elements in PF-induced apoptosis.	Curcumin	116-124	mitogen-activated protein kinase 8	Homo sapiens	135-138
15256484-0	2004	Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	17-40
15256484-3	2004	While curcumin inhibits NFkappaB, its effects upon the MAPK pathways are unclear.	Curcumin	6-14	nuclear factor kappa B subunit 1	Homo sapiens	24-32
15256484-4	2004	This study investigates curcumin effects upon MAPK signalling and apoptosis in HCT116 cells.	Curcumin	24-32	mitogen-activated protein kinase 1	Homo sapiens	46-50
15256484-5	2004	Here we report that curcumin time- and dose-dependent induction of apoptosis were accompanied by sustained phosphorylation and activation of c-jun N-terminal kinase (JNK) and p38 MAPK as well as inhibition of constitutive NFkappaB transcriptional activity.	Curcumin	20-28	mitogen-activated protein kinase 8	Homo sapiens	141-164
15256484-5	2004	Here we report that curcumin time- and dose-dependent induction of apoptosis were accompanied by sustained phosphorylation and activation of c-jun N-terminal kinase (JNK) and p38 MAPK as well as inhibition of constitutive NFkappaB transcriptional activity.	Curcumin	20-28	mitogen-activated protein kinase 8	Homo sapiens	166-169
15256484-5	2004	Here we report that curcumin time- and dose-dependent induction of apoptosis were accompanied by sustained phosphorylation and activation of c-jun N-terminal kinase (JNK) and p38 MAPK as well as inhibition of constitutive NFkappaB transcriptional activity.	Curcumin	20-28	mitogen-activated protein kinase 1	Homo sapiens	175-178
15256484-5	2004	Here we report that curcumin time- and dose-dependent induction of apoptosis were accompanied by sustained phosphorylation and activation of c-jun N-terminal kinase (JNK) and p38 MAPK as well as inhibition of constitutive NFkappaB transcriptional activity.	Curcumin	20-28	mitogen-activated protein kinase 1	Homo sapiens	179-183
15256484-5	2004	Here we report that curcumin time- and dose-dependent induction of apoptosis were accompanied by sustained phosphorylation and activation of c-jun N-terminal kinase (JNK) and p38 MAPK as well as inhibition of constitutive NFkappaB transcriptional activity.	Curcumin	20-28	nuclear factor kappa B subunit 1	Homo sapiens	222-230
15256484-6	2004	Curcumin treatment also induced JNK-dependent sustained phosphorylation of c-jun and stimulation of AP-1 transcriptional activity.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	32-35
15256484-7	2004	Curcumin-mediated c-jun phosphorylation and apoptosis were reduced by treatment with the JNK-specific inhibitor SP600125.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	89-92
15351317-9	2004	Additionally, curcumin and SB203580 suppressed PG-induced production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha), whereas PD98059 showed an inhibitory effect only on the TNF-alpha production.	Curcumin	14-22	tumor necrosis factor	Mus musculus	94-121
15351317-9	2004	Additionally, curcumin and SB203580 suppressed PG-induced production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha), whereas PD98059 showed an inhibitory effect only on the TNF-alpha production.	Curcumin	14-22	tumor necrosis factor	Mus musculus	123-132
15367490-12	2004	MLC mutations impaired folding, and the defect was corrected in vitro by addition of curcumin, a Ca(2+)-ATPase inhibitor.	Curcumin	85-93	modulator of VRAC current 1	Homo sapiens	0-3
15810596-4	2004	Above 10 mg/L concentrations curcumin induced apoptosis [Apoptosis ratio &gt; or = (14.6 +/- 1.8)%, P &lt; 0.05] and down-regulated of the expression of NF-kappaB [Expression ratio &lt; or = (35.8 +/- 4.2)%, P &lt; 0.05], Cyclin D1 [Expression ratio &lt; or = (29.7 +/- 3.2)%, P &lt; 0.05].	Curcumin	29-37	nuclear factor kappa B subunit 1	Homo sapiens	153-162
15203111-3	2004	Curcumin pre and post-treatment (PPT) was shown to decrease the levels of xanthine oxidase, superoxide anion, lipid peroxides (LPs) and myeloperoxidase while the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) activities were significantly increased after curcumin PPT.	Curcumin	0-8	catalase	Rattus norvegicus	200-208
15203111-3	2004	Curcumin pre and post-treatment (PPT) was shown to decrease the levels of xanthine oxidase, superoxide anion, lipid peroxides (LPs) and myeloperoxidase while the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) activities were significantly increased after curcumin PPT.	Curcumin	0-8	catalase	Rattus norvegicus	210-213
15501456-0	2004	Curcumin inhibits mitogen stimulated lymphocyte proliferation, NFkappaB activation, and IL-2 signaling.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	63-71
15501456-0	2004	Curcumin inhibits mitogen stimulated lymphocyte proliferation, NFkappaB activation, and IL-2 signaling.	Curcumin	0-8	interleukin 2	Homo sapiens	88-92
15501456-3	2004	Here we report the inhibitory effects of Curcumin on mitogen-stimulated lymphocyte proliferation, IL-2 synthesis/signaling, and NFkappaB (transcription factor of IL-2 promoter) activation.	Curcumin	41-49	interleukin 2	Homo sapiens	98-102
15501456-3	2004	Here we report the inhibitory effects of Curcumin on mitogen-stimulated lymphocyte proliferation, IL-2 synthesis/signaling, and NFkappaB (transcription factor of IL-2 promoter) activation.	Curcumin	41-49	nuclear factor kappa B subunit 1	Homo sapiens	128-136
15501456-3	2004	Here we report the inhibitory effects of Curcumin on mitogen-stimulated lymphocyte proliferation, IL-2 synthesis/signaling, and NFkappaB (transcription factor of IL-2 promoter) activation.	Curcumin	41-49	interleukin 2	Homo sapiens	162-166
15252836-4	2004	Treatment of MDA 686LN cells with curcumin (diferuloylmethane), a pharmacologically safe chemopreventive agent, inhibited NF-kappaB activation through abrogation of IKK.	Curcumin	34-42	nuclear factor kappa B subunit 1	Homo sapiens	122-131
15252836-4	2004	Treatment of MDA 686LN cells with curcumin (diferuloylmethane), a pharmacologically safe chemopreventive agent, inhibited NF-kappaB activation through abrogation of IKK.	Curcumin	44-61	nuclear factor kappa B subunit 1	Homo sapiens	122-131
15252836-8	2004	Our results indicate that curcumin is a potent inhibitor of cell proliferation and an inducer of apoptosis in HNSCC through suppression of IKK-mediated NF-kappaB activation and of NF-kappaB-regulated gene expression.	Curcumin	26-34	nuclear factor kappa B subunit 1	Homo sapiens	152-161
15252836-8	2004	Our results indicate that curcumin is a potent inhibitor of cell proliferation and an inducer of apoptosis in HNSCC through suppression of IKK-mediated NF-kappaB activation and of NF-kappaB-regulated gene expression.	Curcumin	26-34	nuclear factor kappa B subunit 1	Homo sapiens	180-189
15073046-7	2004	Curcumin (20 micro M) significantly inhibited LPS-induced COX-2 expression; this effect, rather than the catalytic inhibition of COX, may contribute to the decreased PGE(2) formation.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
15073046-8	2004	Without LPS-stimulation, however, curcumin increased the COX-2 level in the macrophage cells.	Curcumin	34-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
15073046-10	2004	Curcumin and THC potently inhibited the activity of human recombinant 5-LOX, showing estimated IC(50) values of 0.7 and 3 micro M, respectively.	Curcumin	0-8	arachidonate 5-lipoxygenase	Homo sapiens	70-75
15073046-11	2004	The results suggest that curcumin affects arachidonic acid metabolism by blocking the phosphorylation of cPLA(2), decreasing the expression of COX-2 and inhibiting the catalytic activities of 5-LOX.	Curcumin	25-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-148
15073046-11	2004	The results suggest that curcumin affects arachidonic acid metabolism by blocking the phosphorylation of cPLA(2), decreasing the expression of COX-2 and inhibiting the catalytic activities of 5-LOX.	Curcumin	25-33	arachidonate 5-lipoxygenase	Homo sapiens	192-197
15090465-0	2004	Curcumin impairs tumor suppressor p53 function in colon cancer cells.	Curcumin	0-8	tumor protein p53	Homo sapiens	34-37
15090465-4	2004	Curcumin contains an alpha,beta-unsaturated ketone, a reactive chemical substituent that is responsible for its repression of NF-kappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	126-135
15090465-5	2004	In compounds other than curcumin this same electrophilic moiety is associated with inactivation of the tumor suppressor, p53.	Curcumin	24-32	tumor protein p53	Homo sapiens	121-124
15358181-3	2004	After the AP-1 inhibition by curcumin analogs in TPA-treated HT-1080 human fibrosarcoma cells, a decrease in mRNA expression of c-jun and MMP3 (stromelysin-1) has been observed.	Curcumin	29-37	matrix metallopeptidase 3	Homo sapiens	144-157
15358181-6	2004	Through the reverse transcriptase-polymerase chain reaction experiment, we confirmed that curcumin analogs down-regulated the expression of angiogenesis-associated genes, VEGF and MMP-9.	Curcumin	90-98	vascular endothelial growth factor A	Homo sapiens	171-175
15304329-9	2004	In addition, intracellular function of HPO that increases the phosphorylation of c-Jun leading to potentiate the AP-1 activity is inhibited by curcumin, a potent inhibitor of CSN-associated kinase.	Curcumin	143-151	Jun proto-oncogene, AP-1 transcription factor subunit	Canis lupus familiaris	81-86
15194816-8	2004	The stretch-induced augmentation of both IL-8 and MCP-3 expression was significantly suppressed by an activator protein-1 (AP-1) inhibitor, curcumin.	Curcumin	140-148	C-X-C motif chemokine ligand 8	Homo sapiens	41-45
14742295-3	2004	This effect is likely to be linked to the fact that although curcumin induces the expression of the phase 2 detoxification enzymes heme oxygenase 1 and glutathione S-transferase P1 (GST P1) in NLF, SLF are deficient in these enzymes, particularly after curcumin treatment.	Curcumin	61-69	glutathione S-transferase pi 1	Rattus norvegicus	152-180
14742295-3	2004	This effect is likely to be linked to the fact that although curcumin induces the expression of the phase 2 detoxification enzymes heme oxygenase 1 and glutathione S-transferase P1 (GST P1) in NLF, SLF are deficient in these enzymes, particularly after curcumin treatment.	Curcumin	61-69	glutathione S-transferase pi 1	Rattus norvegicus	182-188
14742295-3	2004	This effect is likely to be linked to the fact that although curcumin induces the expression of the phase 2 detoxification enzymes heme oxygenase 1 and glutathione S-transferase P1 (GST P1) in NLF, SLF are deficient in these enzymes, particularly after curcumin treatment.	Curcumin	253-261	glutathione S-transferase pi 1	Rattus norvegicus	182-188
14742295-4	2004	The sensitivity of cells to curcumin-induced apoptosis and the expression of GST P1 (but not heme oxygenase 1) are regulated by the epsilon isoform of protein kinase C (PKCepsilon).	Curcumin	28-36	glutathione S-transferase pi 1	Rattus norvegicus	77-83
15252141-4	2004	In this study, we investigated the mechanism by which curcumin augments TRAIL-induced cytotoxicity in LNCaP cells.	Curcumin	54-62	TNF superfamily member 10	Homo sapiens	72-77
15356994-5	2004	Subsequently, curcumin inhibits the activation of NF(nucleor factor)kappaB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs and iNOS.	Curcumin	14-22	AKT serine/threonine kinase 1	Homo sapiens	167-170
15356994-5	2004	Subsequently, curcumin inhibits the activation of NF(nucleor factor)kappaB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs and iNOS.	Curcumin	14-22	nitric oxide synthase 2	Homo sapiens	181-185
15183117-4	2004	We found that mitogen, interleukin-2 (IL-2) or alloantigen induced proliferation of splenic lymphocytes, and development of cytotoxic T lymphocytes is significantly suppressed at 12.5-30 micromol/L curcumin.	Curcumin	198-206	interleukin 2	Homo sapiens	23-36
15183117-4	2004	We found that mitogen, interleukin-2 (IL-2) or alloantigen induced proliferation of splenic lymphocytes, and development of cytotoxic T lymphocytes is significantly suppressed at 12.5-30 micromol/L curcumin.	Curcumin	198-206	interleukin 2	Homo sapiens	38-42
15183117-7	2004	Curcumin also inhibited the expression/production of IL-2 and interferon-gamma (IFN-gamma) by splenic T lymphocytes and IL-12 and tumor necrosis factor-alpha (TNF-alpha) by peritoneal macrophages irreversibly.	Curcumin	0-8	interleukin 2	Homo sapiens	53-57
15183117-7	2004	Curcumin also inhibited the expression/production of IL-2 and interferon-gamma (IFN-gamma) by splenic T lymphocytes and IL-12 and tumor necrosis factor-alpha (TNF-alpha) by peritoneal macrophages irreversibly.	Curcumin	0-8	interferon gamma	Homo sapiens	62-78
15183117-7	2004	Curcumin also inhibited the expression/production of IL-2 and interferon-gamma (IFN-gamma) by splenic T lymphocytes and IL-12 and tumor necrosis factor-alpha (TNF-alpha) by peritoneal macrophages irreversibly.	Curcumin	0-8	interferon gamma	Homo sapiens	80-89
15183117-7	2004	Curcumin also inhibited the expression/production of IL-2 and interferon-gamma (IFN-gamma) by splenic T lymphocytes and IL-12 and tumor necrosis factor-alpha (TNF-alpha) by peritoneal macrophages irreversibly.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	130-157
15183117-7	2004	Curcumin also inhibited the expression/production of IL-2 and interferon-gamma (IFN-gamma) by splenic T lymphocytes and IL-12 and tumor necrosis factor-alpha (TNF-alpha) by peritoneal macrophages irreversibly.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	159-168
15183117-8	2004	Curcumin inhibited the activation of the transcription factor nuclear factor kappaB (NF-kappaB) without affecting the levels of constitutively expressed NF-kappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	77-83
15183117-8	2004	Curcumin inhibited the activation of the transcription factor nuclear factor kappaB (NF-kappaB) without affecting the levels of constitutively expressed NF-kappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	85-94
15183117-9	2004	The latter result suggests that curcumin most likely inhibits cell proliferation, cell-mediated cytotoxicity (CMC), and cytokine production by inhibiting NF-kappaB target genes involved in induction of these immune responses.	Curcumin	32-40	nuclear factor kappa B subunit 1	Homo sapiens	154-163
15200418-0	2004	Curcumin blocks multiple sites of the TGF-beta signaling cascade in renal cells.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	38-46
15200418-3	2004	Here, we investigate curcumin"s ability to modulate TGF-beta"s profibrotic actions in vitro.	Curcumin	21-29	transforming growth factor, beta 1	Rattus norvegicus	52-60
15200418-6	2004	RESULTS: When applied 30 minutes before TGF-beta, curcumin dose dependently and dramatically reduced TGF-beta-induced increases in plasminogen activator inhibitor-1 (PAI-1), TGF-beta1, fibronectin (FN) and collagen I (Col I) mRNA, and in PAI-1 and fibronectin protein.	Curcumin	50-58	transforming growth factor, beta 1	Rattus norvegicus	40-48
15200418-6	2004	RESULTS: When applied 30 minutes before TGF-beta, curcumin dose dependently and dramatically reduced TGF-beta-induced increases in plasminogen activator inhibitor-1 (PAI-1), TGF-beta1, fibronectin (FN) and collagen I (Col I) mRNA, and in PAI-1 and fibronectin protein.	Curcumin	50-58	transforming growth factor, beta 1	Rattus norvegicus	101-109
15200418-6	2004	RESULTS: When applied 30 minutes before TGF-beta, curcumin dose dependently and dramatically reduced TGF-beta-induced increases in plasminogen activator inhibitor-1 (PAI-1), TGF-beta1, fibronectin (FN) and collagen I (Col I) mRNA, and in PAI-1 and fibronectin protein.	Curcumin	50-58	serpin family E member 1	Rattus norvegicus	131-164
15200418-6	2004	RESULTS: When applied 30 minutes before TGF-beta, curcumin dose dependently and dramatically reduced TGF-beta-induced increases in plasminogen activator inhibitor-1 (PAI-1), TGF-beta1, fibronectin (FN) and collagen I (Col I) mRNA, and in PAI-1 and fibronectin protein.	Curcumin	50-58	serpin family E member 1	Rattus norvegicus	166-171
15200418-6	2004	RESULTS: When applied 30 minutes before TGF-beta, curcumin dose dependently and dramatically reduced TGF-beta-induced increases in plasminogen activator inhibitor-1 (PAI-1), TGF-beta1, fibronectin (FN) and collagen I (Col I) mRNA, and in PAI-1 and fibronectin protein.	Curcumin	50-58	transforming growth factor, beta 1	Rattus norvegicus	174-183
15200418-6	2004	RESULTS: When applied 30 minutes before TGF-beta, curcumin dose dependently and dramatically reduced TGF-beta-induced increases in plasminogen activator inhibitor-1 (PAI-1), TGF-beta1, fibronectin (FN) and collagen I (Col I) mRNA, and in PAI-1 and fibronectin protein.	Curcumin	50-58	serpin family E member 1	Rattus norvegicus	238-243
15200418-7	2004	Prolonged curcumin treatment (&gt;6 h) significantly reduced TGF-beta receptor type II levels and SMAD2/3 phosphorylation in response to added TGF-beta.	Curcumin	10-18	transforming growth factor, beta 1	Rattus norvegicus	61-69
15200418-8	2004	Depletion of cellular c-jun levels with a RNAi method mimicked the effects of curcumin on expression of TGF-beta1, FN, and Col I, but not PAI-1.	Curcumin	78-86	transforming growth factor, beta 1	Rattus norvegicus	104-113
15200418-9	2004	CONCLUSION: Curcumin blocks TGF-beta"s profibrotic actions on renal fibroblasts through down-regulation of TbetaRII, and through partial inhibition of c-jun activity.	Curcumin	12-20	transforming growth factor, beta 1	Rattus norvegicus	28-36
15252141-0	2004	Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	45-100
15252141-0	2004	Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	101-106
15252141-0	2004	Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-kappaB through suppression of IkappaBalpha phosphorylation.	Curcumin	0-8	NFKB inhibitor alpha	Homo sapiens	166-178
15532722-4	2004	Western blot evaluation revealed SEA was able to induce nuclear translocation of NF-kappaB from cytosol to nucleus in PBMC, which could be abolished by a NF-kappaB inhibitor such as pyrrolidine dithiocarbamate (PDTC), sodium pyrithione (Pyri), N-acetyl-L-cysteine (NAC), or curcumin (Cur).	Curcumin	274-282	nuclear factor kappa B subunit 1	Homo sapiens	81-90
15532722-4	2004	Western blot evaluation revealed SEA was able to induce nuclear translocation of NF-kappaB from cytosol to nucleus in PBMC, which could be abolished by a NF-kappaB inhibitor such as pyrrolidine dithiocarbamate (PDTC), sodium pyrithione (Pyri), N-acetyl-L-cysteine (NAC), or curcumin (Cur).	Curcumin	274-282	nuclear factor kappa B subunit 1	Homo sapiens	154-163
15252141-5	2004	Subtoxic concentrations of the curcumin-TRAIL combination induced strong apoptotic response in LNCaP cells as demonstrated by the binding of Annexin V-FITC and cleavage of procaspase-3.	Curcumin	31-39	TNF superfamily member 10	Homo sapiens	40-45
15252141-5	2004	Subtoxic concentrations of the curcumin-TRAIL combination induced strong apoptotic response in LNCaP cells as demonstrated by the binding of Annexin V-FITC and cleavage of procaspase-3.	Curcumin	31-39	caspase 3	Homo sapiens	172-184
15252141-8	2004	Pretreatment with curcumin inhibited the activation of NF-kappaB and sensitized LNCaP cells to TRAIL.	Curcumin	18-26	TNF superfamily member 10	Homo sapiens	95-100
15252141-10	2004	Finally, curcumin was found to inhibit NF-kappaB by blocking phosphorylation of IkappaBalpha.	Curcumin	9-17	NFKB inhibitor alpha	Homo sapiens	80-92
15252141-11	2004	We conclude that NF-kappaB mediates resistance of LNCaP cells to TRAIL and that curcumin enhances the sensitivity of these tumor cells to TRAIL by inhibiting NF-kappaB activation by blocking phosphorylation of IkappaBalpha and its degradation.	Curcumin	80-88	TNF superfamily member 10	Homo sapiens	138-143
15252141-11	2004	We conclude that NF-kappaB mediates resistance of LNCaP cells to TRAIL and that curcumin enhances the sensitivity of these tumor cells to TRAIL by inhibiting NF-kappaB activation by blocking phosphorylation of IkappaBalpha and its degradation.	Curcumin	80-88	NFKB inhibitor alpha	Homo sapiens	210-222
15260112-3	2004	The superoxidase dismutase and catalase enzyme activities of curcumin and selenium co-treated animal lenses showed an enhancement.	Curcumin	61-69	catalase	Rattus norvegicus	31-39
15129424-17	2004	Curcumin is able to interfere with the osteoblastic component as well as the osteoclastic component of this phenotype, by interfering with the growth factor receptor pathways and by inhibiting the NF-kappa B activation process.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	197-207
15044435-0	2004	Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function.	Curcumin	25-33	involucrin	Homo sapiens	59-69
15044435-12	2004	The curcumin-dependent suppression of C/EBP factor level is inhibited by treatment with the proteasome inhibitor MG132, suggesting that the proteasome function is required for curcumin action.	Curcumin	4-12	CCAAT enhancer binding protein alpha	Homo sapiens	38-43
15044435-12	2004	The curcumin-dependent suppression of C/EBP factor level is inhibited by treatment with the proteasome inhibitor MG132, suggesting that the proteasome function is required for curcumin action.	Curcumin	176-184	CCAAT enhancer binding protein alpha	Homo sapiens	38-43
15044435-13	2004	We conclude that curcumin and EGCG produce opposing effects on involucrin gene expression via regulation of C/EBP factor function.	Curcumin	17-25	involucrin	Homo sapiens	63-73
15044435-13	2004	We conclude that curcumin and EGCG produce opposing effects on involucrin gene expression via regulation of C/EBP factor function.	Curcumin	17-25	CCAAT enhancer binding protein alpha	Homo sapiens	108-113
15179184-0	2004	Inhibition of nuclear factor-kappaB and nitric oxide by curcumin induces G2/M cell cycle arrest and apoptosis in human melanoma cells.	Curcumin	56-64	nuclear factor kappa B subunit 1	Homo sapiens	14-35
15179184-2	2004	Recent studies have shown that curcumin is both a nitric oxide scavenger and an inhibitor of inducible nitric oxide synthase (iNOS) expression, low levels of which correlate with antiapoptotic function and poor survival and which may be regulated by inhibition of nuclear factor-kappaB (NFkappaB) activation.	Curcumin	31-39	nitric oxide synthase 2	Homo sapiens	93-124
15179184-4	2004	Curcumin induced melanoma cell apoptosis and cell cycle arrest, which is associated with the downregulation of NFkappaB activation, iNOS and DNA-dependent protein kinase catalytic subunit expression, and upregulation of p53, p21(Cip1), p27(Kip1) and checkpoint kinase 2.	Curcumin	0-8	tumor protein p53	Homo sapiens	220-223
15179184-4	2004	Curcumin induced melanoma cell apoptosis and cell cycle arrest, which is associated with the downregulation of NFkappaB activation, iNOS and DNA-dependent protein kinase catalytic subunit expression, and upregulation of p53, p21(Cip1), p27(Kip1) and checkpoint kinase 2.	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	225-228
15179184-2	2004	Recent studies have shown that curcumin is both a nitric oxide scavenger and an inhibitor of inducible nitric oxide synthase (iNOS) expression, low levels of which correlate with antiapoptotic function and poor survival and which may be regulated by inhibition of nuclear factor-kappaB (NFkappaB) activation.	Curcumin	31-39	nitric oxide synthase 2	Homo sapiens	126-130
15179184-4	2004	Curcumin induced melanoma cell apoptosis and cell cycle arrest, which is associated with the downregulation of NFkappaB activation, iNOS and DNA-dependent protein kinase catalytic subunit expression, and upregulation of p53, p21(Cip1), p27(Kip1) and checkpoint kinase 2.	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	229-233
15179184-5	2004	Curcumin also downregulated constitutive iNOS activity in melanoma cells.	Curcumin	0-8	nitric oxide synthase 2	Homo sapiens	41-45
15179184-2	2004	Recent studies have shown that curcumin is both a nitric oxide scavenger and an inhibitor of inducible nitric oxide synthase (iNOS) expression, low levels of which correlate with antiapoptotic function and poor survival and which may be regulated by inhibition of nuclear factor-kappaB (NFkappaB) activation.	Curcumin	31-39	nuclear factor kappa B subunit 1	Homo sapiens	264-285
15179184-6	2004	Our results demonstrate that curcumin arrested cell growth at the G(2)/M phase and induced apoptosis in human melanoma cells by inhibiting NFkappaB activation and thus depletion of endogenous nitric oxide.	Curcumin	29-37	nuclear factor kappa B subunit 1	Homo sapiens	139-147
15179184-2	2004	Recent studies have shown that curcumin is both a nitric oxide scavenger and an inhibitor of inducible nitric oxide synthase (iNOS) expression, low levels of which correlate with antiapoptotic function and poor survival and which may be regulated by inhibition of nuclear factor-kappaB (NFkappaB) activation.	Curcumin	31-39	nuclear factor kappa B subunit 1	Homo sapiens	287-295
15179184-4	2004	Curcumin induced melanoma cell apoptosis and cell cycle arrest, which is associated with the downregulation of NFkappaB activation, iNOS and DNA-dependent protein kinase catalytic subunit expression, and upregulation of p53, p21(Cip1), p27(Kip1) and checkpoint kinase 2.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	111-119
15179184-4	2004	Curcumin induced melanoma cell apoptosis and cell cycle arrest, which is associated with the downregulation of NFkappaB activation, iNOS and DNA-dependent protein kinase catalytic subunit expression, and upregulation of p53, p21(Cip1), p27(Kip1) and checkpoint kinase 2.	Curcumin	0-8	nitric oxide synthase 2	Homo sapiens	132-136
15071361-7	2004	An inhibitor of AP-1, curcumin, or an anti-oxidant, N-acetylcysteine, also inhibited the TNF-alpha-induced IL-8 expression in HUVEC.	Curcumin	22-30	tumor necrosis factor	Homo sapiens	89-98
15142674-8	2004	A decrease in expression of p53, bcl-2, and bcl-X(L) was observed after 12 h exposure of 40 microM curcumin.	Curcumin	99-107	tumor protein p53	Homo sapiens	28-31
15142674-8	2004	A decrease in expression of p53, bcl-2, and bcl-X(L) was observed after 12 h exposure of 40 microM curcumin.	Curcumin	99-107	BCL2 apoptosis regulator	Homo sapiens	33-38
15142674-8	2004	A decrease in expression of p53, bcl-2, and bcl-X(L) was observed after 12 h exposure of 40 microM curcumin.	Curcumin	99-107	BCL2 like 1	Homo sapiens	44-52
15128775-6	2004	Curcumin inhibited the pathway leading from activation of IkappaBalpha kinase and IkappaBalpha phosphorylation to IkappaBalpha degradation.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	82-94
15128775-6	2004	Curcumin inhibited the pathway leading from activation of IkappaBalpha kinase and IkappaBalpha phosphorylation to IkappaBalpha degradation.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	82-94
15128775-7	2004	RANKL induced osteoclastogenesis in these monocytic cells, and curcumin inhibited both RANKL- and TNF-induced osteoclastogenesis and pit formation.	Curcumin	63-71	tumor necrosis factor	Mus musculus	98-101
15128775-10	2004	Thus overall these results indicate that RANKL induces osteoclastogenesis through the activation of NF-kappaB, and treatment with curcumin inhibits both the NF-kappaB activation and osteoclastogenesis induced by RANKL.	Curcumin	130-138	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-166
15140256-14	2004	In addition, curcumin affected expression of metallothionein genes, tubulin genes, p53 and other genes involved in colon carcinogenesis.	Curcumin	13-21	tumor protein p53	Homo sapiens	83-86
15100369-12	2004	As compared with MCP-1, MIP-2 mRNA expression was inhibited by a high dose of curcumin but not by NF-kappaB decoy oligodeoxynucleotide and individual inhibitions of MAP kinase, suggesting that the additional signaling pathway with NF-kappaB might be involved in mRNA expression of MIP-2.	Curcumin	78-86	chemokine (C-X-C motif) ligand 2	Mus musculus	24-29
15100369-12	2004	As compared with MCP-1, MIP-2 mRNA expression was inhibited by a high dose of curcumin but not by NF-kappaB decoy oligodeoxynucleotide and individual inhibitions of MAP kinase, suggesting that the additional signaling pathway with NF-kappaB might be involved in mRNA expression of MIP-2.	Curcumin	78-86	chemokine (C-X-C motif) ligand 2	Mus musculus	281-286
15118344-5	2004	Pretreatment of curcumin, an inhibitor of c-jun N-terminal kinase (JNK), dose-dependently suppressed the induction of Mn-SOD mRNA by YS 51, but not by 2"-amino-3"-methoxyflavone (PD98059) and 4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)imidazol (SB203580), inhibitors of mitogen-activated protein kinase.	Curcumin	16-24	mitogen-activated protein kinase 8	Homo sapiens	42-65
15118344-5	2004	Pretreatment of curcumin, an inhibitor of c-jun N-terminal kinase (JNK), dose-dependently suppressed the induction of Mn-SOD mRNA by YS 51, but not by 2"-amino-3"-methoxyflavone (PD98059) and 4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)imidazol (SB203580), inhibitors of mitogen-activated protein kinase.	Curcumin	16-24	mitogen-activated protein kinase 8	Homo sapiens	67-70
15128775-0	2004	Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	60-70
15128775-0	2004	Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-96
15128775-0	2004	Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis.	Curcumin	10-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	60-70
15128775-0	2004	Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis.	Curcumin	10-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-96
15128775-5	2004	Treatment of these cells with RANKL activated NF-kappaB, and preexposure of the cells to curcumin completely suppressed RANKL-induced NF-kappaB activation.	Curcumin	89-97	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	134-143
15128775-6	2004	Curcumin inhibited the pathway leading from activation of IkappaBalpha kinase and IkappaBalpha phosphorylation to IkappaBalpha degradation.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	58-70
15095415-5	2004	We report that curcumin prevented PDT-induced JNK activation, mitochondrial release of cytochrome c, caspase-3 activation, and cleavage of PAK2.	Curcumin	15-23	mitogen-activated protein kinase 8	Homo sapiens	46-49
15095415-5	2004	We report that curcumin prevented PDT-induced JNK activation, mitochondrial release of cytochrome c, caspase-3 activation, and cleavage of PAK2.	Curcumin	15-23	cytochrome c, somatic	Homo sapiens	87-99
15095415-5	2004	We report that curcumin prevented PDT-induced JNK activation, mitochondrial release of cytochrome c, caspase-3 activation, and cleavage of PAK2.	Curcumin	15-23	caspase 3	Homo sapiens	101-110
15095415-9	2004	Collectively, these results demonstrate that singlet oxygen triggers JNK activation, cytochrome c release, caspase activation and subsequent apoptotic biochemical changes during PDT and show that curcumin is a potent inhibitor for this process.	Curcumin	196-204	mitogen-activated protein kinase 8	Homo sapiens	69-72
15095415-9	2004	Collectively, these results demonstrate that singlet oxygen triggers JNK activation, cytochrome c release, caspase activation and subsequent apoptotic biochemical changes during PDT and show that curcumin is a potent inhibitor for this process.	Curcumin	196-204	cytochrome c, somatic	Homo sapiens	85-97
15071361-7	2004	An inhibitor of AP-1, curcumin, or an anti-oxidant, N-acetylcysteine, also inhibited the TNF-alpha-induced IL-8 expression in HUVEC.	Curcumin	22-30	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
15070700-7	2004	Suppression of NF-kappaB and STAT3 activation in MM cells by ex vivo treatment with curcumin (diferuloylmethane) resulted in a decrease in adhesion to bone marrow stromal cells, cytokine secretion, and in the viability of cells.	Curcumin	84-92	nuclear factor kappa B subunit 1	Homo sapiens	15-24
15090070-6	2004	In additional studies we found that commercial grade curcuminoid (approximately 77% curcumin, 17% demethoxycurcumin and 3% bisdemthoxycurcumin) decreased MDR-1 gene expression in a dose dependent manner and had about the same potent inhibitory effect on MDR-1 gene expression as our natural curcuminoid mixtures.	Curcumin	53-61	ATP binding cassette subfamily B member 1	Homo sapiens	154-159
15090070-6	2004	In additional studies we found that commercial grade curcuminoid (approximately 77% curcumin, 17% demethoxycurcumin and 3% bisdemthoxycurcumin) decreased MDR-1 gene expression in a dose dependent manner and had about the same potent inhibitory effect on MDR-1 gene expression as our natural curcuminoid mixtures.	Curcumin	53-61	ATP binding cassette subfamily B member 1	Homo sapiens	254-259
15090070-8	2004	Treatment of drug resistant KB-V1 cells with curcumin increased their sensitivity to vinblastine, which was consistent with a decreased MDR-1 gene product, a P-glycoprotein, on the cell plasma membrane.	Curcumin	45-53	ATP binding cassette subfamily B member 1	Homo sapiens	136-141
15090070-8	2004	Treatment of drug resistant KB-V1 cells with curcumin increased their sensitivity to vinblastine, which was consistent with a decreased MDR-1 gene product, a P-glycoprotein, on the cell plasma membrane.	Curcumin	45-53	ATP binding cassette subfamily B member 1	Homo sapiens	158-172
15225217-7	2004	On the other hand, curcumin, a natural product with wound healing properties that inhibits several intracellular signaling pathways, was found to completely abrogate the inhibitory effect of TGF-beta1 on human fetal skin fibroblasts, without affecting the stimulatory action on fibroblasts from adult donors.	Curcumin	19-27	transforming growth factor beta 1	Homo sapiens	191-200
15105504-6	2004	Curcumin also induced the functional appearance of DeltaF508 CFTR protein in the plasma membranes of transfected baby hamster kidney cells.	Curcumin	0-8	CF transmembrane conductance regulator	Homo sapiens	61-65
15105504-7	2004	Thus, curcumin treatment may be able to correct defects associated with the homozygous expression of DeltaF508 CFTR.	Curcumin	6-14	CF transmembrane conductance regulator	Homo sapiens	111-115
15070700-7	2004	Suppression of NF-kappaB and STAT3 activation in MM cells by ex vivo treatment with curcumin (diferuloylmethane) resulted in a decrease in adhesion to bone marrow stromal cells, cytokine secretion, and in the viability of cells.	Curcumin	84-92	signal transducer and activator of transcription 3	Homo sapiens	29-34
15070700-7	2004	Suppression of NF-kappaB and STAT3 activation in MM cells by ex vivo treatment with curcumin (diferuloylmethane) resulted in a decrease in adhesion to bone marrow stromal cells, cytokine secretion, and in the viability of cells.	Curcumin	94-111	nuclear factor kappa B subunit 1	Homo sapiens	15-24
15070700-7	2004	Suppression of NF-kappaB and STAT3 activation in MM cells by ex vivo treatment with curcumin (diferuloylmethane) resulted in a decrease in adhesion to bone marrow stromal cells, cytokine secretion, and in the viability of cells.	Curcumin	94-111	signal transducer and activator of transcription 3	Homo sapiens	29-34
15044619-5	2004	Inhibitors of MRP1 (sulfinpyrazone, verapamil) and GST (dicumarol, curcumin) completely reversed the GSTM1-associated resistance to VCR, indicating that a MRP efflux function is necessary to potentiate GSTM1-mediated resistance to VCR.	Curcumin	67-75	glutathione S-transferase mu 1	Homo sapiens	101-106
15129738-0	2004	Manganese complexes of curcumin analogues: evaluation of hydroxyl radical scavenging ability, superoxide dismutase activity and stability towards hydrolysis.	Curcumin	23-31	superoxide dismutase 1	Homo sapiens	94-114
15139523-9	2004	ITCs such as phenethyl isothiocyanate (PEITC), sulforaphane (SUL), allyl isothiocyanate (AITC), and curcumin (CUR) strongly inhibited LPS-induced NF-kappaB-luciferase activations, whereas RES increased activation at lower dose, but inhibited activation at higher dose, and tea flavonoids and procyanidin dimers had little or no effects.	Curcumin	100-108	nuclear factor kappa B subunit 1	Homo sapiens	146-155
14766535-8	2004	Inhibition of TNF-alpha-induced NF-kappa B activation by selected NF-kappa B inhibitors, curcumin and triptolide, prevented the increase in Caco-2 TJ permeability, indicating that NF-kappa B activation was required for the TNF-alpha-induced increase in Caco-2 TJ permeability.	Curcumin	89-97	tumor necrosis factor	Homo sapiens	14-23
14766535-8	2004	Inhibition of TNF-alpha-induced NF-kappa B activation by selected NF-kappa B inhibitors, curcumin and triptolide, prevented the increase in Caco-2 TJ permeability, indicating that NF-kappa B activation was required for the TNF-alpha-induced increase in Caco-2 TJ permeability.	Curcumin	89-97	nuclear factor kappa B subunit 1	Homo sapiens	32-42
14766535-8	2004	Inhibition of TNF-alpha-induced NF-kappa B activation by selected NF-kappa B inhibitors, curcumin and triptolide, prevented the increase in Caco-2 TJ permeability, indicating that NF-kappa B activation was required for the TNF-alpha-induced increase in Caco-2 TJ permeability.	Curcumin	89-97	nuclear factor kappa B subunit 1	Homo sapiens	66-76
14766535-8	2004	Inhibition of TNF-alpha-induced NF-kappa B activation by selected NF-kappa B inhibitors, curcumin and triptolide, prevented the increase in Caco-2 TJ permeability, indicating that NF-kappa B activation was required for the TNF-alpha-induced increase in Caco-2 TJ permeability.	Curcumin	89-97	nuclear factor kappa B subunit 1	Homo sapiens	66-76
15161054-0	2004	Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma.	Curcumin	0-8	tumor protein p53	Homo sapiens	86-89
14676209-5	2004	In addition, curcumin, a blocker of the transcriptional factor AP-1, partially (35%) canceled this effect.	Curcumin	13-21	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-67
15161054-7	2004	CONCLUSION: Observations suggest that the cytotoxicity, cell cycle arrest and apoptosis induced by curcumin and resveratrol in NB cells may be mediated via functionally activated p53 and merit further study.	Curcumin	99-107	tumor protein p53	Homo sapiens	179-182
15129738-1	2004	In order to improve the antioxidant property of curcumin and its analogue, diacetylcurcumin, manganese was incorporated into the structures in order to enhance superoxide dismutase (SOD) activity.	Curcumin	48-56	superoxide dismutase 1	Homo sapiens	160-180
15129738-1	2004	In order to improve the antioxidant property of curcumin and its analogue, diacetylcurcumin, manganese was incorporated into the structures in order to enhance superoxide dismutase (SOD) activity.	Curcumin	48-56	superoxide dismutase 1	Homo sapiens	182-185
15037818-0	2004	Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor kappab bindings in BV2 microglial cells.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	128-134
15037818-6	2004	Furthermore, curcumin markedly inhibited LPS-induced nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1) DNA bindings.	Curcumin	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	68-74
15037818-7	2004	These data suggest that curcumin suppresses LPS-induced COX-2 gene expression by inhibiting NF-kappaB and AP-1 DNA bindings in BV2 microglial cells.	Curcumin	24-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	92-101
15037818-6	2004	Furthermore, curcumin markedly inhibited LPS-induced nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1) DNA bindings.	Curcumin	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-85
15203565-8	2004	Notably, specific inhibitors of NF-kappaB (sulfasalazine and curcumin) inhibited M. bovis-induced IL-8 secretion from U937 cells or HEp-2 cells.	Curcumin	61-69	nuclear factor kappa B subunit 1	Homo sapiens	32-41
14530869-5	2004	RESULTS: Curcumin induced cell death in HL-60 cells, both sensitive and with the MDR phenotype, which could be classified as caspase-3-dependent apoptosis, together with cytochrome c release, activation of caspase-3 and oligonucleosomal DNA fragmentation.	Curcumin	9-17	caspase 3	Homo sapiens	125-134
14530869-5	2004	RESULTS: Curcumin induced cell death in HL-60 cells, both sensitive and with the MDR phenotype, which could be classified as caspase-3-dependent apoptosis, together with cytochrome c release, activation of caspase-3 and oligonucleosomal DNA fragmentation.	Curcumin	9-17	cytochrome c, somatic	Homo sapiens	170-182
14530869-5	2004	RESULTS: Curcumin induced cell death in HL-60 cells, both sensitive and with the MDR phenotype, which could be classified as caspase-3-dependent apoptosis, together with cytochrome c release, activation of caspase-3 and oligonucleosomal DNA fragmentation.	Curcumin	9-17	caspase 3	Homo sapiens	206-215
15072439-5	2004	Curcumin, ginsenosides, piperine, some catechins from green tea, and silymarin from milk thistle were found to be inhibitors of Pgp, while some catechins from green tea increased Pgp-mediated drug transport by heterotropic allosteric mechanism, and St. John"s wort induced the intestinal expression of Pgp in vitro and in vivo.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	128-131
15072439-5	2004	Curcumin, ginsenosides, piperine, some catechins from green tea, and silymarin from milk thistle were found to be inhibitors of Pgp, while some catechins from green tea increased Pgp-mediated drug transport by heterotropic allosteric mechanism, and St. John"s wort induced the intestinal expression of Pgp in vitro and in vivo.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	179-182
15072439-5	2004	Curcumin, ginsenosides, piperine, some catechins from green tea, and silymarin from milk thistle were found to be inhibitors of Pgp, while some catechins from green tea increased Pgp-mediated drug transport by heterotropic allosteric mechanism, and St. John"s wort induced the intestinal expression of Pgp in vitro and in vivo.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	179-182
14604899-7	2004	Ashsp70 cells released more cytochrome c, AIF and Smac from mitochondria upon curcumin treatment than control cells.	Curcumin	78-86	cytochrome c, somatic	Homo sapiens	28-40
14604899-10	2004	Curcumin-induced cleavage of PARP and DFF45 was inhibited by hsp70 but enhanced in Ashsp70 cells.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	29-33
15203565-8	2004	Notably, specific inhibitors of NF-kappaB (sulfasalazine and curcumin) inhibited M. bovis-induced IL-8 secretion from U937 cells or HEp-2 cells.	Curcumin	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
14724571-8	2004	JNK activation and PARP cleavage induced by 30 nM Taxotere at 48 h were reversed by curcumin, PD169316 and SP600125, JNK inhibitors in order of progressive specificity.	Curcumin	84-92	mitogen-activated protein kinase 8	Homo sapiens	0-3
14724571-8	2004	JNK activation and PARP cleavage induced by 30 nM Taxotere at 48 h were reversed by curcumin, PD169316 and SP600125, JNK inhibitors in order of progressive specificity.	Curcumin	84-92	mitogen-activated protein kinase 8	Homo sapiens	117-120
14637190-0	2003	Direct inhibitory effect of curcumin on Src and focal adhesion kinase activity.	Curcumin	28-36	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	40-43
14531733-9	2004	This was further supported by the observation that curcumin suppressed both the DNA-binding activity of NF-kappaB and the induction of MnSOD mRNA in cells cultivated under metal-depleted conditions.	Curcumin	51-59	nuclear factor kappa B subunit 1	Homo sapiens	104-113
14755151-8	2004	FGF-2 induced AP-1-DNA binding activity, and the c-Jun/AP-1 inhibitor curcumin attenuated the FGF-2-induced MMP-1, -3 and TIMP-1 mRNA expression.	Curcumin	70-78	fibroblast growth factor 2	Homo sapiens	94-99
14755151-8	2004	FGF-2 induced AP-1-DNA binding activity, and the c-Jun/AP-1 inhibitor curcumin attenuated the FGF-2-induced MMP-1, -3 and TIMP-1 mRNA expression.	Curcumin	70-78	matrix metallopeptidase 13	Homo sapiens	108-117
14755151-8	2004	FGF-2 induced AP-1-DNA binding activity, and the c-Jun/AP-1 inhibitor curcumin attenuated the FGF-2-induced MMP-1, -3 and TIMP-1 mRNA expression.	Curcumin	70-78	TIMP metallopeptidase inhibitor 1	Homo sapiens	122-128
14722241-5	2004	Below sublethal concentrations of curcumin (10 microM), several invasion-related genes were suppressed, including matrix metalloproteinase 14 (MMP14; 0.65-fold), neuronal cell adhesion molecule (0.54-fold), and integrins alpha6 (0.67-fold) and beta4 (0.63-fold).	Curcumin	34-42	neuronal cell adhesion molecule	Homo sapiens	162-193
14637190-5	2003	Remarkably, curcumin not only exerted its negative effect on FAK via the disappearance of Src-mediated FAK phosphorylation, but also directly inhibited its enzymatic activity.	Curcumin	12-20	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	90-93
14637190-7	2003	To our knowledge, this is the first report indicating that curcumin can retard cellular growth and migration via downregulation of Src and FAK kinase activity.	Curcumin	59-67	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	131-134
14637190-2	2003	In this study, we observed that curcumin inhibited the kinase activity of v-Src, which led to a decrease in tyrosyl substrate phosphorylation of Shc, cortactin, and FAK.	Curcumin	32-40	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	76-79
14637190-3	2003	Our in vitro kinase experiment revealed that the inhibitory effect of curcumin on Src could be direct.	Curcumin	70-78	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	82-85
14680379-3	2003	In isolated membrane vesicles of MRP1- and MRP2-expressing Sf9 cells, curcumin clearly inhibited both MRP1- and MRP2-mediated transport with IC(50) values of 15 and 5 microM, respectively.	Curcumin	70-78	ATP binding cassette subfamily C member 2	Canis lupus familiaris	43-47
14739610-8	2003	To determine that the higher levels of apoptosis in HT29 cells with SC236 &gt;75 microM were related to decreased Cox-2 protein levels, we decreased Cox-2 protein expression in HT29 cells with curcumin (diferuloylmethane) and studied its effect on SC236-induced apoptosis.	Curcumin	193-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-154
14680379-10	2003	In conclusion, curcumin clearly inhibits both MRP1- and MRP2-mediated transport, but the glutathione-dependent metabolism of curcumin plays a crucial role in the ultimate level of inhibition of MRP-mediated transport that can be achieved in a cellular system.	Curcumin	15-23	ATP binding cassette subfamily C member 2	Canis lupus familiaris	56-60
14637278-9	2003	RESULTS: Curcumin (10 and 100 micromol/l) inhibited TNF-alpha secretion from trypsin or activating peptide-stimulated HMC-1.	Curcumin	9-17	tumor necrosis factor	Homo sapiens	52-61
14637278-10	2003	Curcumin (10 and 100 micromol/l) also inhibited TNF-alpha and tryptase mRNA expression in trypsin-stimulated HMC-1.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	48-57
14637278-11	2003	Furthermore, curcumin inhibited trypsin-induced extracellular signal-regulated kinase (ERK) phosphorylation.	Curcumin	13-21	mitogen-activated protein kinase 1	Homo sapiens	48-85
14637278-11	2003	Furthermore, curcumin inhibited trypsin-induced extracellular signal-regulated kinase (ERK) phosphorylation.	Curcumin	13-21	mitogen-activated protein kinase 1	Homo sapiens	87-90
14637278-13	2003	CONCLUSION: Curcumin inhibits PAR2- and PAR4-mediated human mast cell activation, not by inhibition of trypsin activity but by block of ERK pathway.	Curcumin	12-20	mitogen-activated protein kinase 1	Homo sapiens	136-139
14680379-3	2003	In isolated membrane vesicles of MRP1- and MRP2-expressing Sf9 cells, curcumin clearly inhibited both MRP1- and MRP2-mediated transport with IC(50) values of 15 and 5 microM, respectively.	Curcumin	70-78	ATP binding cassette subfamily C member 2	Canis lupus familiaris	112-116
14680379-9	2003	From dose-response curves with Sf9 membrane vesicles, glutathionylcurcumin conjugates appeared to be less potent inhibitors of MRP1 and MRP2 than their parent compound curcumin.	Curcumin	66-74	ATP binding cassette subfamily C member 2	Canis lupus familiaris	136-140
14605272-15	2003	This cytokine- and growth factor-stimulated CX3CL1/fractalkine expression could be abolished by the nuclear factor-kappaB inhibitors, curcumin and MG132.	Curcumin	134-142	C-X3-C motif chemokine ligand 1	Rattus norvegicus	44-50
14557382-4	2003	Injection of curcumin significantly inhibited the rapid transcriptional suppression of CYP2E1, and blocked that of CYP3A2.	Curcumin	13-21	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	87-93
14992327-7	2003	A significant increase in reduced glutathione (GSH) levels, SOD and CAT activities was also observed in all the four brain regions in rats simultaneously treated with curcumin and lead.	Curcumin	167-175	catalase	Rattus norvegicus	68-71
14634121-3	2003	In both rat primary microglia and murine BV2 microglial cells, curcumin effectively suppressed the ganglioside-, LPS-, or IFN-gamma-stimulated induction of cyclooxygenase-2 and inducible NO synthase, important enzymes that mediate inflammatory processes.	Curcumin	63-71	interferon gamma	Mus musculus	122-131
14634121-3	2003	In both rat primary microglia and murine BV2 microglial cells, curcumin effectively suppressed the ganglioside-, LPS-, or IFN-gamma-stimulated induction of cyclooxygenase-2 and inducible NO synthase, important enzymes that mediate inflammatory processes.	Curcumin	63-71	nitric oxide synthase 2, inducible	Mus musculus	177-198
14634121-7	2003	We further show that activation of Src homology 2 domain-containing protein tyrosine phosphatases (SHP)-2, a negative regulator of JAK activity, is likely to be one of the mechanisms underlying the curcumin-mediated inhibition of JAK-STAT signaling.	Curcumin	198-206	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	99-105
14634121-8	2003	Treatment of microglial cells with curcumin led to an increase in phosphorylation and association with JAK1/2 of SHP-2, which inhibit the initiation of JAK-STAT inflammatory signaling in activated microglia.	Curcumin	35-43	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	113-118
14634121-9	2003	Taken together, these data suggest curcumin suppresses JAK-STAT signaling via activation of SHP-2, thus attenuating inflammatory response of brain microglial cells.	Curcumin	35-43	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	92-97
14726605-5	2003	However, experiments with known inhibitors of activation of these transcription factors: pyrrolidine dithiocarbamate (PDTC), parthenolide and curcumin, indicate that NFkappaB and AP-1 cannot be solely responsible for the cytokine induced expression of stromelysin-1 gene in mouse astrocytes.	Curcumin	142-150	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	166-174
14674708-5	2003	Curcumin treatment at similar doses as those used to inhibit HIV gene expression also effectively blocked UV activation of NF-kappaB, as demonstrated by electrophoretic mobility shift assay.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	123-132
14674708-8	2003	Although curcumin was ineffective in preventing UV-induced p44/42 MAP kinase phosphorylation, the JNK (1 and 2) and AP-1 activation were efficiently blocked by curcumin in HeLa cells.	Curcumin	160-168	mitogen-activated protein kinase 8	Homo sapiens	98-110
14674708-9	2003	We conclude that the mechanism by which curcumin modulates UV activation of HIV-LTR gene expression mainly involves the inhibition of NF-kappaB activation.	Curcumin	40-48	nuclear factor kappa B subunit 1	Homo sapiens	134-143
14605272-15	2003	This cytokine- and growth factor-stimulated CX3CL1/fractalkine expression could be abolished by the nuclear factor-kappaB inhibitors, curcumin and MG132.	Curcumin	134-142	C-X3-C motif chemokine ligand 1	Rattus norvegicus	51-62
14728887-12	2003	Yet curcumin could significantly decrease collagen type IV and III in the supernatant of cultured mesangial cells induced by LPS (20.5 +/- 1.00, P &lt; 0.05 and 20.5 +/- 4.12 ng/ml, P &lt; 0.05) and down-regulated the mRNA expression of IL-1 beta and MCP-1 in mesangial cells induced by LPS (P &lt; 0.01).	Curcumin	4-12	interleukin 1 beta	Mus musculus	237-246
14728887-12	2003	Yet curcumin could significantly decrease collagen type IV and III in the supernatant of cultured mesangial cells induced by LPS (20.5 +/- 1.00, P &lt; 0.05 and 20.5 +/- 4.12 ng/ml, P &lt; 0.05) and down-regulated the mRNA expression of IL-1 beta and MCP-1 in mesangial cells induced by LPS (P &lt; 0.01).	Curcumin	4-12	mast cell protease 1	Mus musculus	251-256
14728887-13	2003	CONCLUSION: Curcumin could inhibit the human mesangial cell proliferation and alter the extracellular matrix turnover, meanwhile it could down-regulate the IL-1 beta and MCP-1 mRNA expression induced by LPS, which may be valuable in decreasing the progression of glomerulosclerosis.	Curcumin	12-20	interleukin 1 beta	Homo sapiens	156-165
14642080-11	2003	Curcumin inhibited the transcript levels of two major angiogenesis factors VEGF (vascular endothelial growth factor) and b-FGF (basic fibroblast growth factor) in ER-negative MDA-MB-231 cells.	Curcumin	0-8	fibroblast growth factor 2	Homo sapiens	128-158
14642080-6	2003	RESULTS: Curcumin inhibit the proliferation in both estrogen receptor (ER) positive MCF-7 cells and ER negative MDA-MB-231 cells.	Curcumin	9-17	estrogen receptor 1	Homo sapiens	52-69
12859962-10	2003	Both 5-lipoxygenase inhibition-induced activation of JNK and induction of apoptosis are prevented by curcumin, an inhibitor of JNK-signaling pathway.	Curcumin	101-109	arachidonate 5-lipoxygenase	Homo sapiens	5-19
14642080-6	2003	RESULTS: Curcumin inhibit the proliferation in both estrogen receptor (ER) positive MCF-7 cells and ER negative MDA-MB-231 cells.	Curcumin	9-17	estrogen receptor 1	Homo sapiens	71-73
14642080-6	2003	RESULTS: Curcumin inhibit the proliferation in both estrogen receptor (ER) positive MCF-7 cells and ER negative MDA-MB-231 cells.	Curcumin	9-17	estrogen receptor 1	Homo sapiens	100-102
14642080-7	2003	Curcumin"s antiproliferative effects are estrogen dependent in ER positive MCF-7 cells.	Curcumin	0-8	estrogen receptor 1	Homo sapiens	63-65
14642080-8	2003	Curcumin inhibits the expression of ER downstream genes including pS2 and TGF-alpha (transforming growth factor-alpha) in ER-positive MCF-7 cells, and this inhibition is also dependent on the presence of estrogen.	Curcumin	0-8	trefoil factor 1	Homo sapiens	66-69
14642080-8	2003	Curcumin inhibits the expression of ER downstream genes including pS2 and TGF-alpha (transforming growth factor-alpha) in ER-positive MCF-7 cells, and this inhibition is also dependent on the presence of estrogen.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	85-117
14642080-11	2003	Curcumin inhibited the transcript levels of two major angiogenesis factors VEGF (vascular endothelial growth factor) and b-FGF (basic fibroblast growth factor) in ER-negative MDA-MB-231 cells.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	75-79
14642080-11	2003	Curcumin inhibited the transcript levels of two major angiogenesis factors VEGF (vascular endothelial growth factor) and b-FGF (basic fibroblast growth factor) in ER-negative MDA-MB-231 cells.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	81-115
14642080-11	2003	Curcumin inhibited the transcript levels of two major angiogenesis factors VEGF (vascular endothelial growth factor) and b-FGF (basic fibroblast growth factor) in ER-negative MDA-MB-231 cells.	Curcumin	0-8	fibroblast growth factor 2	Homo sapiens	121-126
14555224-2	2003	Curcumin, a natural compound extracted from Curcuma longa, has shown strong antioxidant and anticancer properties and also the ability to regulate a wide variety of genes that require activating protein 1 and nuclear factor kappaB (NF-kappaB) activation.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	232-241
14555224-4	2003	Curcumin efficiently inhibited the tumour necrosis factor alpha- and phorbol ester-induced binding of AP-1 and NF-kappaB transcription factors to sites located on the GSTP1-1 gene promoter.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	111-120
14555224-5	2003	TNFalpha-induced GSTP1-1 promoter activity was also inhibited by curcumin as shown by reporter gene assay.	Curcumin	65-73	tumor necrosis factor	Homo sapiens	0-8
14500688-7	2003	Compared with AG490, a well-characterized Janus kinase 2 inhibitor, curcumin was a more rapid (30 min vs 8 h) and more potent (10 micro M vs 100 micro M) inhibitor of STAT3 phosphorylation.	Curcumin	68-76	signal transducer and activator of transcription 3	Homo sapiens	167-172
14500688-12	2003	Overall, our results demonstrated that curcumin was a potent inhibitor of STAT3 phosphorylation, and this plays a role in the suppression of MM proliferation.	Curcumin	39-47	signal transducer and activator of transcription 3	Homo sapiens	74-79
12844482-0	2003	Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	159-168
12844482-8	2003	Curcumin treatment attenuated TPA- stimulated NF-kappaB activation in mouse skin, which was associated with its blockade of degradation of the inhibitory protein IkappaBalpha and also of subsequent translocation of the p65 subunit to nucleus.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	46-55
12844482-8	2003	Curcumin treatment attenuated TPA- stimulated NF-kappaB activation in mouse skin, which was associated with its blockade of degradation of the inhibitory protein IkappaBalpha and also of subsequent translocation of the p65 subunit to nucleus.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	162-174
15015361-4	2003	RESULT: Curcumin (50 mg.kg-1, 100 mg.kg-1, 150 mg.kg-1), like biophenyldicarboxylate, were shown to significantly inhibit the increase of serum ALT, AST, NO and liver molondialdehyde (MDA) content induced by CCl4, D-Gal N, BCG + LPS.	Curcumin	8-16	transmembrane protease, serine 11d	Mus musculus	149-152
14505349-3	2003	In this study we demonstrate that curcumin (Cur), the yellow pigment of Curcuma longa with known anti-oxidant and anti-inflammatory properties, can prevent UV irradiation-induced apoptotic changes, including c-Jun N-terminal kinase (JNK) activation, loss of mitochondrial membrane potential (MMP), mitochondrial release of cytochrome C, caspase-3 activation, and cleavage/activation of PAK2 in A431 cells.	Curcumin	34-42	mitogen-activated protein kinase 8	Homo sapiens	233-236
14505349-3	2003	In this study we demonstrate that curcumin (Cur), the yellow pigment of Curcuma longa with known anti-oxidant and anti-inflammatory properties, can prevent UV irradiation-induced apoptotic changes, including c-Jun N-terminal kinase (JNK) activation, loss of mitochondrial membrane potential (MMP), mitochondrial release of cytochrome C, caspase-3 activation, and cleavage/activation of PAK2 in A431 cells.	Curcumin	34-42	cytochrome c, somatic	Homo sapiens	323-335
14505349-3	2003	In this study we demonstrate that curcumin (Cur), the yellow pigment of Curcuma longa with known anti-oxidant and anti-inflammatory properties, can prevent UV irradiation-induced apoptotic changes, including c-Jun N-terminal kinase (JNK) activation, loss of mitochondrial membrane potential (MMP), mitochondrial release of cytochrome C, caspase-3 activation, and cleavage/activation of PAK2 in A431 cells.	Curcumin	34-42	caspase 3	Homo sapiens	337-346
14500688-0	2003	Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells.	Curcumin	0-8	interleukin 6	Homo sapiens	55-59
14500688-0	2003	Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	70-75
14500688-0	2003	Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells.	Curcumin	10-27	interleukin 6	Homo sapiens	55-59
14500688-0	2003	Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells.	Curcumin	10-27	signal transducer and activator of transcription 3	Homo sapiens	70-75
14500688-3	2003	In the present report, we demonstrate that curcumin (diferuloylmethane), a pharmacologically safe agent in humans, inhibited IL-6-induced STAT3 phosphorylation and consequent STAT3 nuclear translocation.	Curcumin	43-51	interleukin 6	Homo sapiens	125-129
14500688-3	2003	In the present report, we demonstrate that curcumin (diferuloylmethane), a pharmacologically safe agent in humans, inhibited IL-6-induced STAT3 phosphorylation and consequent STAT3 nuclear translocation.	Curcumin	43-51	signal transducer and activator of transcription 3	Homo sapiens	138-143
14500688-3	2003	In the present report, we demonstrate that curcumin (diferuloylmethane), a pharmacologically safe agent in humans, inhibited IL-6-induced STAT3 phosphorylation and consequent STAT3 nuclear translocation.	Curcumin	43-51	signal transducer and activator of transcription 3	Homo sapiens	175-180
14500688-3	2003	In the present report, we demonstrate that curcumin (diferuloylmethane), a pharmacologically safe agent in humans, inhibited IL-6-induced STAT3 phosphorylation and consequent STAT3 nuclear translocation.	Curcumin	53-70	interleukin 6	Homo sapiens	125-129
14500688-3	2003	In the present report, we demonstrate that curcumin (diferuloylmethane), a pharmacologically safe agent in humans, inhibited IL-6-induced STAT3 phosphorylation and consequent STAT3 nuclear translocation.	Curcumin	53-70	signal transducer and activator of transcription 3	Homo sapiens	138-143
14500688-3	2003	In the present report, we demonstrate that curcumin (diferuloylmethane), a pharmacologically safe agent in humans, inhibited IL-6-induced STAT3 phosphorylation and consequent STAT3 nuclear translocation.	Curcumin	53-70	signal transducer and activator of transcription 3	Homo sapiens	175-180
14500688-4	2003	Curcumin had no effect on STAT5 phosphorylation, but inhibited the IFN-alpha-induced STAT1 phosphorylation.	Curcumin	0-8	interferon alpha 1	Homo sapiens	67-76
14500688-5	2003	The constitutive phosphorylation of STAT3 found in certain MM cells was also abrogated by treatment with curcumin.	Curcumin	105-113	signal transducer and activator of transcription 3	Homo sapiens	36-41
14500688-6	2003	Curcumin-induced inhibition of STAT3 phosphorylation was reversible.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	31-36
12890714-7	2003	LPS-stimulated TNF-alpha release and PMA-stimulated superoxide generation were significantly suppressed by curcumin.	Curcumin	107-115	tumor necrosis factor	Rattus norvegicus	15-24
12890714-8	2003	Furthermore, curcumin inhibited the increases in lung MPO activity, TGF-beta1 expression, lung hydroxyproline content, expression of type I collagen and c-Jun protein in amiodarone rats.	Curcumin	13-21	transforming growth factor, beta 1	Rattus norvegicus	68-77
12878172-6	2003	Inhibitors of the transcription factors AP-1 (nordihydroguaiaretic acid, NDGA) and NF-kappaB (curcumin, proteasome inhibitors, and Bay-11-7085) suppressed TNF-alpha-induced MMP-13 expression in primary chondrocytes and SW1353 cells.	Curcumin	94-102	tumor necrosis factor	Homo sapiens	155-164
12859962-10	2003	Both 5-lipoxygenase inhibition-induced activation of JNK and induction of apoptosis are prevented by curcumin, an inhibitor of JNK-signaling pathway.	Curcumin	101-109	mitogen-activated protein kinase 8	Homo sapiens	53-56
12859962-10	2003	Both 5-lipoxygenase inhibition-induced activation of JNK and induction of apoptosis are prevented by curcumin, an inhibitor of JNK-signaling pathway.	Curcumin	101-109	mitogen-activated protein kinase 8	Homo sapiens	127-130
12637253-8	2003	We conclude that the widely used food additive curcumin is able to attenuate experimental colitis through a mechanism correlated with the inhibition of the activation of NF-kappaB and effects a reduction in the activity of p38 MAPK.	Curcumin	47-55	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	170-179
12853969-7	2003	TGF-beta1 activated c-Jun phosphorylation, and IL-6 induction by TGF-beta1 was severely impeded by DN-c-Jun and DN-JNK or AP-1 inhibitor curcumin, showing that the JNK-c-Jun-AP-1 signaling plays a pivotal role in TGF-beta1 stimulation of IL-6.	Curcumin	137-145	transforming growth factor beta 1	Homo sapiens	0-9
12853969-7	2003	TGF-beta1 activated c-Jun phosphorylation, and IL-6 induction by TGF-beta1 was severely impeded by DN-c-Jun and DN-JNK or AP-1 inhibitor curcumin, showing that the JNK-c-Jun-AP-1 signaling plays a pivotal role in TGF-beta1 stimulation of IL-6.	Curcumin	137-145	interleukin 6	Homo sapiens	47-51
12853969-7	2003	TGF-beta1 activated c-Jun phosphorylation, and IL-6 induction by TGF-beta1 was severely impeded by DN-c-Jun and DN-JNK or AP-1 inhibitor curcumin, showing that the JNK-c-Jun-AP-1 signaling plays a pivotal role in TGF-beta1 stimulation of IL-6.	Curcumin	137-145	transforming growth factor beta 1	Homo sapiens	65-74
12853969-7	2003	TGF-beta1 activated c-Jun phosphorylation, and IL-6 induction by TGF-beta1 was severely impeded by DN-c-Jun and DN-JNK or AP-1 inhibitor curcumin, showing that the JNK-c-Jun-AP-1 signaling plays a pivotal role in TGF-beta1 stimulation of IL-6.	Curcumin	137-145	transforming growth factor beta 1	Homo sapiens	65-74
12807725-0	2003	Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	68-77
12807725-0	2003	Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.	Curcumin	10-27	nuclear factor kappa B subunit 1	Homo sapiens	68-77
12807725-0	2003	Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.	Curcumin	0-8	NFKB inhibitor alpha	Homo sapiens	111-123
12807725-0	2003	Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.	Curcumin	10-27	NFKB inhibitor alpha	Homo sapiens	111-123
12807725-0	2003	Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.	Curcumin	10-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
12807727-4	2003	Treatment of Caki cells with 50 microM curcumin resulted in the activation of caspase 3, cleavage of phospholipase C-gamma1 and DNA fragmentation.	Curcumin	39-47	caspase 3	Homo sapiens	78-87
12807727-4	2003	Treatment of Caki cells with 50 microM curcumin resulted in the activation of caspase 3, cleavage of phospholipase C-gamma1 and DNA fragmentation.	Curcumin	39-47	phospholipase C gamma 1	Homo sapiens	101-123
12807725-9	2003	Exposure of cells to CS induced persistent activation of NF-kappaB, and pre-treatment with curcumin abolished the CS-induced DNA-binding of NF-kappaB, IkappaBalpha kinase activation, IkBalpha phosphorylation and degradation, p65 nuclear translocation and CS-induced NF-kappaB-dependent reporter gene expression.	Curcumin	91-99	nuclear factor kappa B subunit 1	Homo sapiens	57-66
12807727-6	2003	Curcumin causes dose-dependent apoptosis and DNA fragmentation of Caki cells, which is preceded by the sequential dephosphorylation of Akt, down-regulation of the anti-apoptotic Bcl-2, Bcl-XL and IAP proteins, release of cytochrome c and activation of caspase 3.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	135-138
12807725-9	2003	Exposure of cells to CS induced persistent activation of NF-kappaB, and pre-treatment with curcumin abolished the CS-induced DNA-binding of NF-kappaB, IkappaBalpha kinase activation, IkBalpha phosphorylation and degradation, p65 nuclear translocation and CS-induced NF-kappaB-dependent reporter gene expression.	Curcumin	91-99	nuclear factor kappa B subunit 1	Homo sapiens	140-149
12807727-6	2003	Curcumin causes dose-dependent apoptosis and DNA fragmentation of Caki cells, which is preceded by the sequential dephosphorylation of Akt, down-regulation of the anti-apoptotic Bcl-2, Bcl-XL and IAP proteins, release of cytochrome c and activation of caspase 3.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	178-183
12807725-9	2003	Exposure of cells to CS induced persistent activation of NF-kappaB, and pre-treatment with curcumin abolished the CS-induced DNA-binding of NF-kappaB, IkappaBalpha kinase activation, IkBalpha phosphorylation and degradation, p65 nuclear translocation and CS-induced NF-kappaB-dependent reporter gene expression.	Curcumin	91-99	NFKB inhibitor alpha	Homo sapiens	151-163
12807727-6	2003	Curcumin causes dose-dependent apoptosis and DNA fragmentation of Caki cells, which is preceded by the sequential dephosphorylation of Akt, down-regulation of the anti-apoptotic Bcl-2, Bcl-XL and IAP proteins, release of cytochrome c and activation of caspase 3.	Curcumin	0-8	BCL2 like 1	Homo sapiens	185-191
12807725-0	2003	Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	195-200
12807727-6	2003	Curcumin causes dose-dependent apoptosis and DNA fragmentation of Caki cells, which is preceded by the sequential dephosphorylation of Akt, down-regulation of the anti-apoptotic Bcl-2, Bcl-XL and IAP proteins, release of cytochrome c and activation of caspase 3.	Curcumin	0-8	alkaline phosphatase, intestinal	Homo sapiens	196-199
12807725-9	2003	Exposure of cells to CS induced persistent activation of NF-kappaB, and pre-treatment with curcumin abolished the CS-induced DNA-binding of NF-kappaB, IkappaBalpha kinase activation, IkBalpha phosphorylation and degradation, p65 nuclear translocation and CS-induced NF-kappaB-dependent reporter gene expression.	Curcumin	91-99	nuclear factor kappa B subunit 1	Homo sapiens	140-149
12807725-11	2003	Overall our results indicate that CS-induced NF-kappaB activation and NF-kappaB-regulated gene expression in human non-small cell lung carcinoma cells is suppressed by curcumin through suppression of IkappaBalpha kinase.	Curcumin	168-176	nuclear factor kappa B subunit 1	Homo sapiens	45-54
12807725-11	2003	Overall our results indicate that CS-induced NF-kappaB activation and NF-kappaB-regulated gene expression in human non-small cell lung carcinoma cells is suppressed by curcumin through suppression of IkappaBalpha kinase.	Curcumin	168-176	nuclear factor kappa B subunit 1	Homo sapiens	70-79
12807725-11	2003	Overall our results indicate that CS-induced NF-kappaB activation and NF-kappaB-regulated gene expression in human non-small cell lung carcinoma cells is suppressed by curcumin through suppression of IkappaBalpha kinase.	Curcumin	168-176	NFKB inhibitor alpha	Homo sapiens	200-212
12807727-0	2003	Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.	Curcumin	24-32	BCL2 like 1	Homo sapiens	144-150
12807727-0	2003	Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.	Curcumin	24-32	alkaline phosphatase, intestinal	Homo sapiens	155-158
12807727-6	2003	Curcumin causes dose-dependent apoptosis and DNA fragmentation of Caki cells, which is preceded by the sequential dephosphorylation of Akt, down-regulation of the anti-apoptotic Bcl-2, Bcl-XL and IAP proteins, release of cytochrome c and activation of caspase 3.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	221-233
12807727-6	2003	Curcumin causes dose-dependent apoptosis and DNA fragmentation of Caki cells, which is preceded by the sequential dephosphorylation of Akt, down-regulation of the anti-apoptotic Bcl-2, Bcl-XL and IAP proteins, release of cytochrome c and activation of caspase 3.	Curcumin	0-8	caspase 3	Homo sapiens	252-261
12807727-9	2003	The data indicate that curcumin can cause cell damage by inactivating the Akt-related cell survival pathway and release of cytochrome c, providing a new mechanism for curcumin-induced cytotoxicity.	Curcumin	23-31	AKT serine/threonine kinase 1	Homo sapiens	74-77
12807727-0	2003	Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.	Curcumin	24-32	cytochrome c, somatic	Homo sapiens	175-187
12807727-0	2003	Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.	Curcumin	24-32	AKT serine/threonine kinase 1	Homo sapiens	206-209
12473670-13	2003	To our knowledge, this is the first report that OPN induces NF kappa B activity through phosphorylation and degradation of I kappa B alpha by activating IKK that ultimately triggers the activation of pro-MMP-2 and further demonstrates that curcumin potently suppresses OPN-induced cell migration, tumor growth, and NF kappa B-mediated pro-MMP-2 activation by blocking the IKK/I kappa B alpha signaling pathways.	Curcumin	240-248	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	60-70
12854631-5	2003	We also observed a significant decrease in the expression and the release of eotaxin, MCP-1 and MCP-3 in the presence of SB203580, an inhibitor of p38 MAPK (71 +/- 6%, P &lt; 0.05, n = 8 and 39 +/- 10% P &lt; 0.01, n = 10 respectively), curcumin, an inhibitor of JNK kinase (83 +/- 4.9% and 88 +/- 3.4% respectively, P &lt; 0.01, n = 4).	Curcumin	237-245	mitogen-activated protein kinase 14	Homo sapiens	147-150
12870844-1	2003	The excited-state photophysical properties of curcumin in the presence of bovine serum albumin (BSA) have been studied.	Curcumin	46-54	albumin	Homo sapiens	81-94
12527553-11	2003	Interestingly, pretreatment with hemin as well as curcumin (inducers of HO-1) inhibited the ANG II-induced tubular cell apoptosis; conversely, pretreatment with zinc protoporphyrin, an inhibitor of HO-1 expression, promoted the effect of ANG II.	Curcumin	50-58	angiotensinogen	Rattus norvegicus	92-98
12527553-11	2003	Interestingly, pretreatment with hemin as well as curcumin (inducers of HO-1) inhibited the ANG II-induced tubular cell apoptosis; conversely, pretreatment with zinc protoporphyrin, an inhibitor of HO-1 expression, promoted the effect of ANG II.	Curcumin	50-58	angiotensinogen	Rattus norvegicus	238-244
12570874-0	2003	Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
12570874-5	2003	Here, we show that in renal epithelial cells both curcumin and CAPE stimulate the expression of Nrf2 in a concentration- and time-dependent manner.	Curcumin	50-58	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
12570874-7	2003	From several lines of investigation we also report that curcumin (and, by inference, CAPE) stimulates ho-1 gene activity by promoting inactivation of the Nrf2-Keap1 complex, leading to increased Nrf2 binding to the resident ho-1 AREs.	Curcumin	56-64	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
12770926-8	2003	5 Curcumin also reduced the levels of nitric oxide (NO) and O(2)(-) associated with the favourable expression of Th1 and Th2 cytokines and inducible NO synthase.	Curcumin	2-10	negative elongation factor complex member C/D, Th1l	Mus musculus	113-116
12695340-7	2003	Several flavonoids including quercetin, resveratrol, and curcumin were also examined for their ability to induce CYP3A4 in human hepatocytes.	Curcumin	57-65	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	113-119
12682902-0	2003	Inhibition of cell survival signal protein kinase B/Akt by curcumin in human prostate cancer cells.	Curcumin	59-67	AKT serine/threonine kinase 1	Homo sapiens	52-55
12682902-5	2003	Curcumin inhibited completely Akt activation in both LNCaP and PC-3 cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	30-33
12682902-9	2003	Results suggest that one of the mechanisms of curcumin inhibition of prostate cancer may be via inhibition of Akt.	Curcumin	46-54	AKT serine/threonine kinase 1	Homo sapiens	110-113
12682902-10	2003	To our knowledge this is the first report on the curcumin inhibition of Akt activation in LNCaP and PC-3 but not in DU-145 cells.	Curcumin	49-57	AKT serine/threonine kinase 1	Homo sapiens	72-75
12806293-9	2003	Treatment of oxidative-stressed cultures with either curcumin, a MAPKKK pathway inhibitor, or PD-098059, a MEK1 inhibitor, blocked loss of neurons via the JNK/c-Jun apoptotic pathway.	Curcumin	53-61	mitogen-activated protein kinase 8	Homo sapiens	155-158
12473670-5	2003	We also investigated the mechanism of action of curcumin (diferulolylmethane) on OPN-induced NF kappa B-mediated activation of pro-MMP-2 in B16F10 cells.	Curcumin	48-56	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-103
12473670-8	2003	However, curcumin a known anti-inflammatory and anticarcinogenic agent suppressed OPN-induced I kappa B alpha phosphorylation and degradation by inhibiting the IKK activity.	Curcumin	9-17	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	94-109
12473670-9	2003	Moreover, our data revealed that curcumin inhibited the OPN-induced translocation of p65, NF kappa B-DNA binding, and NF kappa B transcriptional activity.	Curcumin	33-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-100
12473670-9	2003	Moreover, our data revealed that curcumin inhibited the OPN-induced translocation of p65, NF kappa B-DNA binding, and NF kappa B transcriptional activity.	Curcumin	33-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	118-128
12807727-9	2003	The data indicate that curcumin can cause cell damage by inactivating the Akt-related cell survival pathway and release of cytochrome c, providing a new mechanism for curcumin-induced cytotoxicity.	Curcumin	23-31	cytochrome c, somatic	Homo sapiens	123-135
12807727-9	2003	The data indicate that curcumin can cause cell damage by inactivating the Akt-related cell survival pathway and release of cytochrome c, providing a new mechanism for curcumin-induced cytotoxicity.	Curcumin	167-175	AKT serine/threonine kinase 1	Homo sapiens	74-77
12807727-9	2003	The data indicate that curcumin can cause cell damage by inactivating the Akt-related cell survival pathway and release of cytochrome c, providing a new mechanism for curcumin-induced cytotoxicity.	Curcumin	167-175	cytochrome c, somatic	Homo sapiens	123-135
12892381-4	2003	The enhanced release of IL-1beta was completely suppressed by pretreatment with verapamil (a calcium entry blocker), U73122 (a phospholipase C inhibitor), W-7 (a calmodulin inhibitor), and curcumin (an activator-protein [AP]-1 inhibitor), and weakly suppressed by dexamethasone (which inhibits nuclear factor [NF]-kappaB and AP-1).	Curcumin	189-197	interleukin 1 beta	Rattus norvegicus	24-32
12570874-7	2003	From several lines of investigation we also report that curcumin (and, by inference, CAPE) stimulates ho-1 gene activity by promoting inactivation of the Nrf2-Keap1 complex, leading to increased Nrf2 binding to the resident ho-1 AREs.	Curcumin	56-64	kelch like ECH associated protein 1	Homo sapiens	159-164
12570874-7	2003	From several lines of investigation we also report that curcumin (and, by inference, CAPE) stimulates ho-1 gene activity by promoting inactivation of the Nrf2-Keap1 complex, leading to increased Nrf2 binding to the resident ho-1 AREs.	Curcumin	56-64	NFE2 like bZIP transcription factor 2	Homo sapiens	195-199
12570874-9	2003	Taken together, these results demonstrate that induction of HO-1 by curcumin and CAPE requires the activation of the Nrf2/ARE pathway.	Curcumin	68-76	NFE2 like bZIP transcription factor 2	Homo sapiens	117-121
12784914-11	2003	Interleukin-1beta increased to 2 folds on day 21 and 10 folds on day 35 which were significantly brought down by curcumin and ibuprofen.	Curcumin	113-121	interleukin 1 beta	Rattus norvegicus	0-17
12869308-0	2003	4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management.	Curcumin	48-56	AKT serine/threonine kinase 1	Homo sapiens	76-79
12869308-0	2003	4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management.	Curcumin	48-56	nuclear factor kappa B subunit 1	Homo sapiens	80-90
12869308-2	2003	We have developed an analogue of curcumin called 4-hydroxy-3-methoxybenzoic acid methyl ester (HMBME) that targets the Akt/NFkappaB signaling pathway.	Curcumin	33-41	AKT serine/threonine kinase 1	Homo sapiens	119-122
12869308-2	2003	We have developed an analogue of curcumin called 4-hydroxy-3-methoxybenzoic acid methyl ester (HMBME) that targets the Akt/NFkappaB signaling pathway.	Curcumin	33-41	nuclear factor kappa B subunit 1	Homo sapiens	123-131
12684045-0	2003	Ruthenium red, inhibitor of mitochondrial Ca2+ uniporter, inhibits curcumin-induced apoptosis via the prevention of intracellular Ca2+ depletion and cytochrome c release.	Curcumin	67-75	cytochrome c, somatic	Homo sapiens	149-161
12684045-4	2003	Curcumin induces apoptosis in U937 cells via a mechanism that appears to involve down-regulation of the anti-apoptotic Bcl-xL, and IAP proteins, release of cytochrome c, and activation of caspase 3.	Curcumin	0-8	BCL2 like 1	Homo sapiens	119-125
12684045-4	2003	Curcumin induces apoptosis in U937 cells via a mechanism that appears to involve down-regulation of the anti-apoptotic Bcl-xL, and IAP proteins, release of cytochrome c, and activation of caspase 3.	Curcumin	0-8	alkaline phosphatase, intestinal	Homo sapiens	131-134
12684045-4	2003	Curcumin induces apoptosis in U937 cells via a mechanism that appears to involve down-regulation of the anti-apoptotic Bcl-xL, and IAP proteins, release of cytochrome c, and activation of caspase 3.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	156-168
12684045-4	2003	Curcumin induces apoptosis in U937 cells via a mechanism that appears to involve down-regulation of the anti-apoptotic Bcl-xL, and IAP proteins, release of cytochrome c, and activation of caspase 3.	Curcumin	0-8	caspase 3	Homo sapiens	188-197
12473670-13	2003	To our knowledge, this is the first report that OPN induces NF kappa B activity through phosphorylation and degradation of I kappa B alpha by activating IKK that ultimately triggers the activation of pro-MMP-2 and further demonstrates that curcumin potently suppresses OPN-induced cell migration, tumor growth, and NF kappa B-mediated pro-MMP-2 activation by blocking the IKK/I kappa B alpha signaling pathways.	Curcumin	240-248	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	123-138
12473670-13	2003	To our knowledge, this is the first report that OPN induces NF kappa B activity through phosphorylation and degradation of I kappa B alpha by activating IKK that ultimately triggers the activation of pro-MMP-2 and further demonstrates that curcumin potently suppresses OPN-induced cell migration, tumor growth, and NF kappa B-mediated pro-MMP-2 activation by blocking the IKK/I kappa B alpha signaling pathways.	Curcumin	240-248	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	315-325
12473670-13	2003	To our knowledge, this is the first report that OPN induces NF kappa B activity through phosphorylation and degradation of I kappa B alpha by activating IKK that ultimately triggers the activation of pro-MMP-2 and further demonstrates that curcumin potently suppresses OPN-induced cell migration, tumor growth, and NF kappa B-mediated pro-MMP-2 activation by blocking the IKK/I kappa B alpha signaling pathways.	Curcumin	240-248	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	376-391
12565848-0	2003	Unique, pH-dependent biphasic band shape of the visible circular dichroism of curcumin-serum albumin complex.	Curcumin	78-86	albumin	Homo sapiens	87-100
12957788-7	2003	Curcumin, a JNK/AP-1 inhibitor, partially abolished the effect of IL-1beta on ATPase expression but did not interfere with the effect of PGE2.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	66-74
12614893-1	2003	Curcumin, the yellow pigment of the rhizome of Curcuma longa is known to inhibit the transcription factors AP-1, Egr-1, NF-kappaB, c-myc and several important signaling kinases.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	120-129
12614893-4	2003	In comparison, the down-regulation of inducible nitric oxide (iNOS) mRNA levels was less pronounced, but interferon gamma (IFN-gamma) mRNA was dose-dependently up-regulated with curcumin concentrations up to 8.2 microM.	Curcumin	178-186	interferon gamma	Homo sapiens	105-132
12594059-11	2003	Curcumin, an inhibitor of AP-1, also reduced BK-induced IL-6 expression.	Curcumin	0-8	kininogen 1	Homo sapiens	45-47
12594059-11	2003	Curcumin, an inhibitor of AP-1, also reduced BK-induced IL-6 expression.	Curcumin	0-8	interleukin 6	Homo sapiens	56-60
12744763-12	2003	Curcumin significantly inhibited MAPK activity both 30 min after SLH (p38: 297 vs. 3260, p44/42: 370 vs. 2628, SAPK: 748 vs. 1764, all p &lt; 0.01 vs. SLH 30 min) and 4 h post CLP (p38: 146 vs. 720, p44/42: 616 vs. 2759, all p &lt; 0.01 vs. SLH + CLP4 h).	Curcumin	0-8	mitogen-activated protein kinase 9	Rattus norvegicus	111-115
12514113-6	2003	Curcumin exposure increased JunD and c-Jun content in AP-1 complexes and increased JunD while decreasing MafG/MafK in EpRE complexes.	Curcumin	0-8	MAF bZIP transcription factor G	Homo sapiens	105-109
12565848-1	2003	Interaction between the plant derived polyphenolic type curcumin molecule having anticarcinogenic, antiinflammatory, and antioxidant activities, and human serum albumin was studied at different pH values by circular dichroism (CD) and electronic absorption spectroscopy.	Curcumin	56-64	albumin	Homo sapiens	155-168
12388178-12	2003	Curcumin blocked endotoxin-mediated activation of NF-kappaB and suppressed the expression of cytokines, chemokines, COX-2, and iNOS in Kupffer cells.	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	127-131
12795836-6	2003	Curcumin, a JNK blocker, blocked the apoptosis and the growth inhibition induced by ATRA.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	12-15
12527329-0	2003	Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells.	Curcumin	153-161	mitogen-activated protein kinase 3	Homo sapiens	47-51
12527329-0	2003	Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells.	Curcumin	153-161	AKT serine/threonine kinase 1	Homo sapiens	110-113
12527329-3	2003	After pre-treatment of cells for 20 min, curcumin (40 microM) inhibited EGF-stimulated phosphorylation of the EGFR in MDA-MB-468 cells and phosphorylation of extracellular signal regulated kinases (ERKs) 1 and 2, as well as ERK activity and levels of nuclear c-fos in both cell lines.	Curcumin	41-49	epidermal growth factor receptor	Homo sapiens	110-114
12527329-3	2003	After pre-treatment of cells for 20 min, curcumin (40 microM) inhibited EGF-stimulated phosphorylation of the EGFR in MDA-MB-468 cells and phosphorylation of extracellular signal regulated kinases (ERKs) 1 and 2, as well as ERK activity and levels of nuclear c-fos in both cell lines.	Curcumin	41-49	mitogen-activated protein kinase 1	Homo sapiens	158-211
12527329-3	2003	After pre-treatment of cells for 20 min, curcumin (40 microM) inhibited EGF-stimulated phosphorylation of the EGFR in MDA-MB-468 cells and phosphorylation of extracellular signal regulated kinases (ERKs) 1 and 2, as well as ERK activity and levels of nuclear c-fos in both cell lines.	Curcumin	41-49	mitogen-activated protein kinase 3	Homo sapiens	198-201
12527329-6	2003	Curcumin inhibited basal phosphorylation of Akt/protein kinase B (PKB) in both cell lines, but more consistently and to a greater extent in the MDA-MB-468 cells.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	66-69
12527329-9	2003	These results suggest that while curcumin has several different molecular targets within the MAPK and PI3K/PKB signalling pathways that could contribute to inhibition of proliferation and induction of apoptosis, inhibition of basal activity of Akt/PKB, but not ERK, may facilitate apoptosis in the tumour cell line.	Curcumin	33-41	mitogen-activated protein kinase 3	Homo sapiens	93-97
12527329-9	2003	These results suggest that while curcumin has several different molecular targets within the MAPK and PI3K/PKB signalling pathways that could contribute to inhibition of proliferation and induction of apoptosis, inhibition of basal activity of Akt/PKB, but not ERK, may facilitate apoptosis in the tumour cell line.	Curcumin	33-41	AKT serine/threonine kinase 1	Homo sapiens	107-110
12527329-9	2003	These results suggest that while curcumin has several different molecular targets within the MAPK and PI3K/PKB signalling pathways that could contribute to inhibition of proliferation and induction of apoptosis, inhibition of basal activity of Akt/PKB, but not ERK, may facilitate apoptosis in the tumour cell line.	Curcumin	33-41	AKT serine/threonine kinase 1	Homo sapiens	244-251
12527329-9	2003	These results suggest that while curcumin has several different molecular targets within the MAPK and PI3K/PKB signalling pathways that could contribute to inhibition of proliferation and induction of apoptosis, inhibition of basal activity of Akt/PKB, but not ERK, may facilitate apoptosis in the tumour cell line.	Curcumin	33-41	mitogen-activated protein kinase 3	Homo sapiens	261-264
12488237-5	2003	Curcumin markedly inhibited NF-kappaB and AP-1 activation, assessed by DNA binding and degradation of inhibitory IkappaB proteins, and the induction of mRNAs for cytokines IL-6 and TNF-alpha, the chemokine KC, and inducible nitric oxide synthase in pancreas.	Curcumin	0-8	interleukin 6	Rattus norvegicus	172-176
12393461-0	2003	Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis.	Curcumin	0-8	NFKB inhibitor alpha	Homo sapiens	102-114
12393461-0	2003	Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis.	Curcumin	10-27	NFKB inhibitor alpha	Homo sapiens	102-114
12393461-2	2003	We found that NF-kappaB was constitutively active in all human MM cell lines examined and that curcumin, a chemopreventive agent, down-regulated NF-kappaB in all cell lines as indicated by electrophoretic mobility gel shift assay and prevented the nuclear retention of p65 as shown by immunocytochemistry.	Curcumin	95-103	nuclear factor kappa B subunit 1	Homo sapiens	145-154
12393461-4	2003	Curcumin suppressed the constitutive IkappaBalpha phosphorylation through the inhibition of IKK activity.	Curcumin	0-8	NFKB inhibitor alpha	Homo sapiens	37-49
12393461-5	2003	Curcumin also down-regulated the expression of NF-kappaB-regulated gene products, including IkappaBalpha, Bcl-2, Bcl-x(L), cyclin D1, and interleukin-6.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	47-56
12393461-5	2003	Curcumin also down-regulated the expression of NF-kappaB-regulated gene products, including IkappaBalpha, Bcl-2, Bcl-x(L), cyclin D1, and interleukin-6.	Curcumin	0-8	NFKB inhibitor alpha	Homo sapiens	92-104
12393461-5	2003	Curcumin also down-regulated the expression of NF-kappaB-regulated gene products, including IkappaBalpha, Bcl-2, Bcl-x(L), cyclin D1, and interleukin-6.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	106-111
12393461-5	2003	Curcumin also down-regulated the expression of NF-kappaB-regulated gene products, including IkappaBalpha, Bcl-2, Bcl-x(L), cyclin D1, and interleukin-6.	Curcumin	0-8	BCL2 like 1	Homo sapiens	113-121
12393461-5	2003	Curcumin also down-regulated the expression of NF-kappaB-regulated gene products, including IkappaBalpha, Bcl-2, Bcl-x(L), cyclin D1, and interleukin-6.	Curcumin	0-8	interleukin 6	Homo sapiens	138-151
12393461-8	2003	Curcumin also activated caspase-7 and caspase-9 and induced polyadenosine-5"-diphosphate-ribose polymerase (PARP) cleavage.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	60-106
12393461-8	2003	Curcumin also activated caspase-7 and caspase-9 and induced polyadenosine-5"-diphosphate-ribose polymerase (PARP) cleavage.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	108-112
12393461-9	2003	Curcumin-induced down-regulation of NF-kappaB, a factor that has been implicated in chemoresistance, also induced chemosensitivity to vincristine and melphalan.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	36-45
12393461-10	2003	Overall, our results indicate that curcumin down-regulates NF-kappaB in human MM cells, leading to the suppression of proliferation and induction of apoptosis, thus providing the molecular basis for the treatment of MM patients with this pharmacologically safe agent.	Curcumin	35-43	nuclear factor kappa B subunit 1	Homo sapiens	59-68
12631113-14	2003	In contrast, curcumin, an activating protein (AP)-1 inhibitor, attenuated TNF-alpha-stimulated phospho-c-Jun levels and fractalkine expression without discernible effects on TNF-alpha-induced degradation of I-kappaBalpha or NF-kappaB nuclear translocation.	Curcumin	13-21	tumor necrosis factor	Homo sapiens	74-83
12631113-14	2003	In contrast, curcumin, an activating protein (AP)-1 inhibitor, attenuated TNF-alpha-stimulated phospho-c-Jun levels and fractalkine expression without discernible effects on TNF-alpha-induced degradation of I-kappaBalpha or NF-kappaB nuclear translocation.	Curcumin	13-21	C-X3-C motif chemokine ligand 1	Homo sapiens	120-131
12631113-14	2003	In contrast, curcumin, an activating protein (AP)-1 inhibitor, attenuated TNF-alpha-stimulated phospho-c-Jun levels and fractalkine expression without discernible effects on TNF-alpha-induced degradation of I-kappaBalpha or NF-kappaB nuclear translocation.	Curcumin	13-21	NFKB inhibitor alpha	Homo sapiens	207-220
12631113-14	2003	In contrast, curcumin, an activating protein (AP)-1 inhibitor, attenuated TNF-alpha-stimulated phospho-c-Jun levels and fractalkine expression without discernible effects on TNF-alpha-induced degradation of I-kappaBalpha or NF-kappaB nuclear translocation.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	224-233
12578124-8	2003	In contrast, oral administration of curcumin for 7 days followed by hemorrhage/resuscitation regimen resulted in significant restoration of these cytokines to depleted levels, and, in fact, IL-1beta levels were lower than sham levels.	Curcumin	36-44	interleukin 1 beta	Rattus norvegicus	190-198
12570925-7	2003	Preculture of macrophages with Mg(2+)-deficient medium for 22 h markedly increased NO release and iNOS mRNA levels for a further 2 h; these increments were suppressed completely by curcumin.	Curcumin	181-189	nitric oxide synthase 2	Rattus norvegicus	98-102
12488237-5	2003	Curcumin markedly inhibited NF-kappaB and AP-1 activation, assessed by DNA binding and degradation of inhibitory IkappaB proteins, and the induction of mRNAs for cytokines IL-6 and TNF-alpha, the chemokine KC, and inducible nitric oxide synthase in pancreas.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	181-190
12517775-7	2003	Interestingly, these ErbB-2 mutants are specifically resistant to GA-induced degradation but retain sensitivity to other drugs, such as staurospore and curcumin, which are also able to provoke ErbB-2 degradation.	Curcumin	152-160	erb-b2 receptor tyrosine kinase 2	Homo sapiens	21-27
12517775-7	2003	Interestingly, these ErbB-2 mutants are specifically resistant to GA-induced degradation but retain sensitivity to other drugs, such as staurospore and curcumin, which are also able to provoke ErbB-2 degradation.	Curcumin	152-160	erb-b2 receptor tyrosine kinase 2	Homo sapiens	193-199
12447990-7	2003	Curcumin inhibited the production of IL-6 in this cell suggesting that one of the mechanisms for synergy between cisplatin and curcumin was by reducing the autologous production of IL-6.	Curcumin	0-8	interleukin 6	Homo sapiens	37-41
12447990-7	2003	Curcumin inhibited the production of IL-6 in this cell suggesting that one of the mechanisms for synergy between cisplatin and curcumin was by reducing the autologous production of IL-6.	Curcumin	0-8	interleukin 6	Homo sapiens	181-185
12447990-7	2003	Curcumin inhibited the production of IL-6 in this cell suggesting that one of the mechanisms for synergy between cisplatin and curcumin was by reducing the autologous production of IL-6.	Curcumin	127-135	interleukin 6	Homo sapiens	37-41
12447990-7	2003	Curcumin inhibited the production of IL-6 in this cell suggesting that one of the mechanisms for synergy between cisplatin and curcumin was by reducing the autologous production of IL-6.	Curcumin	127-135	interleukin 6	Homo sapiens	181-185
12678405-0	2003	Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and E-cadherin.	Curcumin	0-8	cadherin 1	Mus musculus	127-137
12678405-8	2003	Curcumin enhances the expression of antimetastatic proteins, tissue inhibitor metalloproteinase (TIMP)-2, nonmetastatic gene 23 (Nm23), and E-cadherin.	Curcumin	0-8	cadherin 1	Mus musculus	140-150
12678405-9	2003	In this article we report on the effect of curcumin on the expression of integrin, TIMP-2, Nm23, E-cadherin, adhesion, and metalloproteinase activity.	Curcumin	43-51	cadherin 1	Mus musculus	97-107
12533677-0	2003	Curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	39-94
12533677-0	2003	Curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells.	Curcumin	10-28	TNF superfamily member 10	Homo sapiens	39-94
12533677-9	2003	These results define a potential use of curcumin to sensitize prostate cancer cells for TRAIL-mediated immunotherapy.	Curcumin	40-48	TNF superfamily member 10	Homo sapiens	88-93
12710595-5	2003	Dietary supplementation of curcumin (2%, w/v) to male ddY mice for 30 days significantly increased the activities of glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase and catalase to 189%, 179%, 189%, and 181% in liver and 143%, 134%, 167% and 115% in kidney respectively as compared with corresponding normal diet fed control (P&lt;0.05-0.001).	Curcumin	27-35	catalase	Mus musculus	202-210
14657599-6	2003	In addition, curcumin significantly inhibited adhesion and haptotactic migration to fibronectin and laminin without affecting the expression of integrins on the cell surface.	Curcumin	13-21	fibronectin 1	Homo sapiens	84-95
12825130-7	2003	A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the IL-17-, IL-1beta-, and TNF-alpha-induced MMP-3 mRNA expression, and mitogen-activated protein (MAP) kinase inhibitors (U0126, PD098059, and SB203580) also blocked MMP-3 secretion.	Curcumin	47-55	interleukin 1 beta	Homo sapiens	77-85
12825130-7	2003	A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the IL-17-, IL-1beta-, and TNF-alpha-induced MMP-3 mRNA expression, and mitogen-activated protein (MAP) kinase inhibitors (U0126, PD098059, and SB203580) also blocked MMP-3 secretion.	Curcumin	47-55	tumor necrosis factor	Homo sapiens	92-101
12825130-7	2003	A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the IL-17-, IL-1beta-, and TNF-alpha-induced MMP-3 mRNA expression, and mitogen-activated protein (MAP) kinase inhibitors (U0126, PD098059, and SB203580) also blocked MMP-3 secretion.	Curcumin	47-55	matrix metallopeptidase 3	Homo sapiens	110-115
12825130-7	2003	A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the IL-17-, IL-1beta-, and TNF-alpha-induced MMP-3 mRNA expression, and mitogen-activated protein (MAP) kinase inhibitors (U0126, PD098059, and SB203580) also blocked MMP-3 secretion.	Curcumin	47-55	matrix metallopeptidase 3	Homo sapiens	232-237
12483537-6	2002	In comparison, the down-regulation by curcumin of cyclin D2 and cyclin D3 was found only in selective cell lines.	Curcumin	38-46	cyclin D2	Homo sapiens	50-59
12466962-4	2002	Results showed that curcumin treatment causes p53- and p21-independent G(2)/M phase arrest and apoptosis in HCT-116(p53(+/+)), HCT-116(p53(-/-)) and HCT-116(p21(-/-)) cell lines.	Curcumin	20-28	tumor protein p53	Homo sapiens	46-49
12466962-4	2002	Results showed that curcumin treatment causes p53- and p21-independent G(2)/M phase arrest and apoptosis in HCT-116(p53(+/+)), HCT-116(p53(-/-)) and HCT-116(p21(-/-)) cell lines.	Curcumin	20-28	tumor protein p53	Homo sapiens	116-119
12466962-4	2002	Results showed that curcumin treatment causes p53- and p21-independent G(2)/M phase arrest and apoptosis in HCT-116(p53(+/+)), HCT-116(p53(-/-)) and HCT-116(p21(-/-)) cell lines.	Curcumin	20-28	tumor protein p53	Homo sapiens	116-119
12466962-9	2002	The curcumin treatment also induced caspase-3-mediated degradation of cell-cell adhesion proteins beta-catenin, E-cadherin and APC, which were linked with apoptosis, and this degradation was prevented with the caspase-3 inhibitor.	Curcumin	4-12	caspase 3	Homo sapiens	36-45
12466962-9	2002	The curcumin treatment also induced caspase-3-mediated degradation of cell-cell adhesion proteins beta-catenin, E-cadherin and APC, which were linked with apoptosis, and this degradation was prevented with the caspase-3 inhibitor.	Curcumin	4-12	cadherin 1	Homo sapiens	112-122
12466962-9	2002	The curcumin treatment also induced caspase-3-mediated degradation of cell-cell adhesion proteins beta-catenin, E-cadherin and APC, which were linked with apoptosis, and this degradation was prevented with the caspase-3 inhibitor.	Curcumin	4-12	caspase 3	Homo sapiens	210-219
12520734-10	2002	CONCLUSIONS: Curcumin could significantly inhibit the growth of ovary cancer cells; inducing apoptosis through up-regulating Caspase-3 and down-regulating expression of NF-kappa B was probably one of its molecular mechanisms.	Curcumin	13-21	caspase 3	Homo sapiens	125-134
12520734-10	2002	CONCLUSIONS: Curcumin could significantly inhibit the growth of ovary cancer cells; inducing apoptosis through up-regulating Caspase-3 and down-regulating expression of NF-kappa B was probably one of its molecular mechanisms.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	169-179
12483537-6	2002	In comparison, the down-regulation by curcumin of cyclin D2 and cyclin D3 was found only in selective cell lines.	Curcumin	38-46	cyclin D3	Homo sapiens	64-73
12379279-10	2002	Curcumin, a potent inhibitor of AP-1 expression, completely abolished the inhibitory effect of TGF-beta on GR-mediated gene expression without affecting GR activity in the absence of TGF-beta, and this drug blocked TGF-beta-induced binding of AP-1 to a response element derived from the MMTV sequence.	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	32-36
12454848-2	2002	The pleiotropic effects of curcumin are attributable at least in part to inhibition of transcriptional factor nuclear factor kappaB (NF-kappaB).	Curcumin	27-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-131
12454848-2	2002	The pleiotropic effects of curcumin are attributable at least in part to inhibition of transcriptional factor nuclear factor kappaB (NF-kappaB).	Curcumin	27-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	133-142
12454848-10	2002	Consistent with these findings, CD4(+) T-cell infiltration and NF-kappaB activation in colonic mucosa were suppressed in the curcumin-treated group.	Curcumin	125-133	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	63-72
12446602-9	2002	When introduced into 3T3-L1 adipocytes, curcumin markedly inhibited insulin-induced GLUT4 translocation and glucose transport.	Curcumin	40-48	insulin	Homo sapiens	68-75
12368225-8	2002	Cerivastatin, a hydroxymethylglutaryl CoA reductase inhibitor; pyrrolidinedithiocarbamate; or curcumin was found to completely prevent the AGE-induced increase in NF-kB and AP-1 activity, VEGF mRNA up-regulation, and the resultant increase in DNA synthesis in microvascular EC.	Curcumin	94-102	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	173-177
12368225-8	2002	Cerivastatin, a hydroxymethylglutaryl CoA reductase inhibitor; pyrrolidinedithiocarbamate; or curcumin was found to completely prevent the AGE-induced increase in NF-kB and AP-1 activity, VEGF mRNA up-regulation, and the resultant increase in DNA synthesis in microvascular EC.	Curcumin	94-102	vascular endothelial growth factor A	Homo sapiens	188-192
12379279-10	2002	Curcumin, a potent inhibitor of AP-1 expression, completely abolished the inhibitory effect of TGF-beta on GR-mediated gene expression without affecting GR activity in the absence of TGF-beta, and this drug blocked TGF-beta-induced binding of AP-1 to a response element derived from the MMTV sequence.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	95-103
12379279-10	2002	Curcumin, a potent inhibitor of AP-1 expression, completely abolished the inhibitory effect of TGF-beta on GR-mediated gene expression without affecting GR activity in the absence of TGF-beta, and this drug blocked TGF-beta-induced binding of AP-1 to a response element derived from the MMTV sequence.	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	243-247
12379279-11	2002	Furthermore, curcumin abolished TGF-beta inhibition of Dex-induced growth suppression.	Curcumin	13-21	transforming growth factor beta 1	Homo sapiens	32-40
12408714-2	2002	Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.	Curcumin	0-8	androgen receptor	Homo sapiens	28-45
12408714-3	2002	A number of curcumin analogues were prepared and evaluated as potential androgen receptor antagonists against two human prostate cancer cell lines, PC-3 and DU-145, in the presence of androgen receptor (AR) and androgen receptor coactivator, ARA70.	Curcumin	12-20	androgen receptor	Homo sapiens	72-89
12509941-7	2002	Both mutation of AP-1 binding site and addition of curcumin markedly decrease of activity of TGF-beta(1) promoter.	Curcumin	51-59	transforming growth factor, beta 1	Rattus norvegicus	93-104
12485871-0	2002	Curcumin induces caspase-3-independent apoptosis in human multidrug-resistant cells.	Curcumin	0-8	caspase 3	Homo sapiens	17-26
12359244-10	2002	Our results on Northern blot analysis clearly indicated a time-dependent (0-24h) inhibition by curcumin of VEGF, angiopoietin 1 and 2 gene expression in EAT cells, VEGF and angiopoietin 1 gene expression in NIH3T3 cells, and KDR gene expression in HUVECs.	Curcumin	95-103	angiopoietin 1	Mus musculus	113-133
12359244-10	2002	Our results on Northern blot analysis clearly indicated a time-dependent (0-24h) inhibition by curcumin of VEGF, angiopoietin 1 and 2 gene expression in EAT cells, VEGF and angiopoietin 1 gene expression in NIH3T3 cells, and KDR gene expression in HUVECs.	Curcumin	95-103	angiopoietin 1	Mus musculus	113-127
12237165-8	2002	Mithramycin A (10(-6) mol/l) and curcumin (10(-6) mol/l), prevented the upregulation of nNOS and ERalpha in neutrophils derived from men, suggesting the involvement of AP-1 and Sp-1 transcription factors.	Curcumin	33-41	estrogen receptor 1	Homo sapiens	97-104
12220969-5	2002	Our results showed that the activities of alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT) in plasma and levels of cholesterol, triglycerides (TGs) and free fatty acids (FFAs) in tissues were increased significantly in both alcohol + raw as well as heated PUFA groups compared to normal, but decreased significantly on treatment with curcumin and IC.	Curcumin	346-354	alkaline phosphatase, placental	Homo sapiens	42-62
12239622-0	2002	Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines.	Curcumin	0-8	androgen receptor	Homo sapiens	24-26
12239622-4	2002	Our results show that curcumin down-regulates transactivation and expression of AR, activator protein-1 (AP-1), nuclear factor-kappaB (NF-kappaB), and CREB (cAMP response element-binding protein)-binding protein (CBP).	Curcumin	22-30	CREB binding protein	Homo sapiens	213-216
12239622-6	2002	The results obtained here demonstrate that curcumin has a potential therapeutic effect on prostate cancer cells through down-regulation of AR and AR-related cofactors (AP-1, NF-kappaB and CBP).	Curcumin	43-51	CREB binding protein	Homo sapiens	188-191
12220536-0	2002	Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes.	Curcumin	37-45	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	71-86
12220536-3	2002	Curcumin treated with CYP 2D6, CYP1A1, or CYP1A2 induced DNA damage in the presence of Cu(II).	Curcumin	0-8	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	22-29
12220536-4	2002	CYP2D6-treated curcumin caused base damage, especially at 5(")-TG-3("), 5(")-GC-3("), and GG sequences.	Curcumin	15-23	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	0-6
12220536-7	2002	Time-of- flight mass spectrometry demonstrated that CYP2D6 catalyzed the conversion of curcumin to O-demethyl curcumin.	Curcumin	87-95	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	52-58
12216086-0	2002	Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	18-31
12216086-0	2002	Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	56-69
12216086-5	2002	RESULTS: The constitutive production of IL-8 was inhibited by curcumin at concentrations of 10-100 microM in a dose dependent manner.	Curcumin	62-70	C-X-C motif chemokine ligand 8	Homo sapiens	40-44
12216086-6	2002	NF-kappaB activity was reduced significantly by curcumin treatment.	Curcumin	48-56	nuclear factor kappa B subunit 1	Homo sapiens	0-9
12216086-9	2002	The investigation of expression in IL-8 receptors, CXCR1 and CXCR2, revealed that the expression of both receptors was enhanced remarkably by curcumin.	Curcumin	142-150	C-X-C motif chemokine ligand 8	Homo sapiens	35-39
12216086-11	2002	These results suggest that curcumin inhibits IL-8-induced receptor internalization.	Curcumin	27-35	C-X-C motif chemokine ligand 8	Homo sapiens	45-49
12216086-12	2002	CONCLUSIONS: The authors concluded that curcumin contributed not only to the inhibition of IL-8 production but also to signal transduction through IL-8 receptors.	Curcumin	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	91-95
12216086-12	2002	CONCLUSIONS: The authors concluded that curcumin contributed not only to the inhibition of IL-8 production but also to signal transduction through IL-8 receptors.	Curcumin	40-48	C-X-C motif chemokine ligand 8	Homo sapiens	147-151
12216086-13	2002	These data suggest that curcumin reduces numerous IL-8 bioactivities that contribute to tumor growth and carcinoma cell viability.	Curcumin	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
12216086-14	2002	From this point of view, curcumin is a potent anticancer agent that inhibits the production of proinflammatory cytokines, including IL-8, by tumor cells.	Curcumin	25-33	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
12220969-5	2002	Our results showed that the activities of alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT) in plasma and levels of cholesterol, triglycerides (TGs) and free fatty acids (FFAs) in tissues were increased significantly in both alcohol + raw as well as heated PUFA groups compared to normal, but decreased significantly on treatment with curcumin and IC.	Curcumin	346-354	alkaline phosphatase, placental	Homo sapiens	64-67
12105223-7	2002	Curcumin, but not PD98059 or SB203580, inhibited IL-1 beta-mediated suppression of nuclear RXR:RAR binding activity, which correlated with inhibition of JNK phosphorylation and phospho-JNK-mediated phosphorylation of RXR.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	49-58
12105223-7	2002	Curcumin, but not PD98059 or SB203580, inhibited IL-1 beta-mediated suppression of nuclear RXR:RAR binding activity, which correlated with inhibition of JNK phosphorylation and phospho-JNK-mediated phosphorylation of RXR.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	153-156
12105223-7	2002	Curcumin, but not PD98059 or SB203580, inhibited IL-1 beta-mediated suppression of nuclear RXR:RAR binding activity, which correlated with inhibition of JNK phosphorylation and phospho-JNK-mediated phosphorylation of RXR.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	185-188
12105223-8	2002	Taken together, these data provide evidence supporting a novel player (JNK), as well as its inhibitor (curcumin), in inflammation-mediated regulation of hepatobiliary transporters and correlate JNK-dependent RXR phosphorylation with reduced RXR-dependent hepatic gene expression.	Curcumin	103-111	mitogen-activated protein kinase 8	Homo sapiens	194-197
12167476-0	2002	Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells.	Curcumin	56-64	ATP binding cassette subfamily B member 1	Homo sapiens	14-28
12167476-3	2002	In this study, curcumin was tested for its potential ability to modulate the expression and function of Pgp in the multidrug-resistant human cervical carcinoma cell line KB-V1.	Curcumin	15-23	ATP binding cassette subfamily B member 1	Homo sapiens	104-107
12167476-4	2002	Western blot analysis and reverse transcription-polymerase chain reaction (RT-PCR) showed that treatment with 1, 5, and 10 microM curcumin for up to 72hr was able to significantly lower Pgp expression in KB-V1 cells.	Curcumin	130-138	ATP binding cassette subfamily B member 1	Homo sapiens	186-189
12167476-5	2002	Curcumin (1-10 microM) decreased Pgp expression in a concentration-dependent manner and was also found to have the same effect on MDR1 mRNA levels.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	33-36
12167476-5	2002	Curcumin (1-10 microM) decreased Pgp expression in a concentration-dependent manner and was also found to have the same effect on MDR1 mRNA levels.	Curcumin	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	130-134
12167476-6	2002	The effect of curcumin on Pgp function was demonstrated by rhodamine 123 (Rh123) accumulation and efflux in Pgp-expressing KB-V1 cells.	Curcumin	14-22	ATP binding cassette subfamily B member 1	Homo sapiens	26-29
12167476-6	2002	The effect of curcumin on Pgp function was demonstrated by rhodamine 123 (Rh123) accumulation and efflux in Pgp-expressing KB-V1 cells.	Curcumin	14-22	ATP binding cassette subfamily B member 1	Homo sapiens	108-111
12167476-9	2002	In addition, curcumin inhibited verapamil-stimulated ATPase activity and the photoaffinity labeling of Pgp with the prazosin analog [125I]iodoarylazidoprazosin in a concentration-dependent manner, demonstrating that curcumin interacts directly with the transporter.	Curcumin	13-21	ATP binding cassette subfamily B member 1	Homo sapiens	103-106
12167476-9	2002	In addition, curcumin inhibited verapamil-stimulated ATPase activity and the photoaffinity labeling of Pgp with the prazosin analog [125I]iodoarylazidoprazosin in a concentration-dependent manner, demonstrating that curcumin interacts directly with the transporter.	Curcumin	216-224	ATP binding cassette subfamily B member 1	Homo sapiens	103-106
12167476-10	2002	Thus, curcumin seems to be able to modulate the in vitro expression and function of Pgp in multidrug-resistant human KB-V1 cells.	Curcumin	6-14	ATP binding cassette subfamily B member 1	Homo sapiens	84-87
12167476-11	2002	In summary, this study describes the duel modulation of MDR1 expression and Pgp function by the phytochemical curcumin, which may be an attractive new agent for the chemosensitization of cancer cells.	Curcumin	110-118	ATP binding cassette subfamily B member 1	Homo sapiens	56-60
12167476-11	2002	In summary, this study describes the duel modulation of MDR1 expression and Pgp function by the phytochemical curcumin, which may be an attractive new agent for the chemosensitization of cancer cells.	Curcumin	110-118	ATP binding cassette subfamily B member 1	Homo sapiens	76-79
12130688-6	2002	Shikoccin (a diterpene), dibenzylideneacetone, and curcumin fit the pharmacophore hypothesis, inhibit cellular isopeptidases, and cause cell death independently of p53 in isogenic pairs of RKO and HCT 116 cells with differential p53 status.	Curcumin	51-59	tumor protein p53	Homo sapiens	164-167
12118335-0	2002	Curcumin inhibits cell cycle progression of immortalized human umbilical vein endothelial (ECV304) cells by up-regulating cyclin-dependent kinase inhibitor, p21WAF1/CIP1, p27KIP1 and p53.	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	157-169
12118335-0	2002	Curcumin inhibits cell cycle progression of immortalized human umbilical vein endothelial (ECV304) cells by up-regulating cyclin-dependent kinase inhibitor, p21WAF1/CIP1, p27KIP1 and p53.	Curcumin	0-8	tumor protein p53	Homo sapiens	183-186
12118335-3	2002	Curcumin was found to induce G0/G1 and/or G2/M phase cell cycle arrest, up-regulate CDKIs, p21WAF1/CIP1, p27KIP1, and p53, and slightly down-regulate cyclin B1 and cdc2 in ECV304 cells.	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	91-103
12118335-3	2002	Curcumin was found to induce G0/G1 and/or G2/M phase cell cycle arrest, up-regulate CDKIs, p21WAF1/CIP1, p27KIP1, and p53, and slightly down-regulate cyclin B1 and cdc2 in ECV304 cells.	Curcumin	0-8	tumor protein p53	Homo sapiens	118-121
12130688-6	2002	Shikoccin (a diterpene), dibenzylideneacetone, and curcumin fit the pharmacophore hypothesis, inhibit cellular isopeptidases, and cause cell death independently of p53 in isogenic pairs of RKO and HCT 116 cells with differential p53 status.	Curcumin	51-59	tumor protein p53	Homo sapiens	229-232
12097302-8	2002	These findings support the hypothesis that dietary curcumin can inhibit chemotherapy-induced apoptosis through inhibition of ROS generation and blockade of JNK function, and suggest that additional studies are needed to determine whether breast cancer patients undergoing chemotherapy should avoid curcumin supplementation, and possibly even limit their exposure to curcumin-containing foods.	Curcumin	51-59	mitogen-activated protein kinase 8	Homo sapiens	156-159
12149148-7	2002	The essential role of JNK in the induction of SCLC apoptosis with CDDP and anti-GD2 mAb was confirmed by experiments with a JNK inhibitor, curcumin.	Curcumin	139-147	mitogen-activated protein kinase 8	Homo sapiens	22-25
12097302-2	2002	However, this agent also inhibits the generation of reactive oxygen species (ROS) and the c-Jun NH(2)-terminal kinase (JNK) pathway, and because many chemotherapeutic drugs generate ROS and activate JNK in the course of inducing apoptosis, we considered the possibility that curcumin might antagonize their antitumor efficacy.	Curcumin	275-283	mitogen-activated protein kinase 8	Homo sapiens	119-122
12097302-2	2002	However, this agent also inhibits the generation of reactive oxygen species (ROS) and the c-Jun NH(2)-terminal kinase (JNK) pathway, and because many chemotherapeutic drugs generate ROS and activate JNK in the course of inducing apoptosis, we considered the possibility that curcumin might antagonize their antitumor efficacy.	Curcumin	275-283	mitogen-activated protein kinase 8	Homo sapiens	199-202
12097302-5	2002	Under these conditions, curcumin exhibited antioxidant properties and inhibited both JNK activation and mitochondrial release of cytochrome c in a concentration-dependent manner.	Curcumin	24-32	mitogen-activated protein kinase 8	Homo sapiens	85-88
12097302-5	2002	Under these conditions, curcumin exhibited antioxidant properties and inhibited both JNK activation and mitochondrial release of cytochrome c in a concentration-dependent manner.	Curcumin	24-32	cytochrome c, somatic	Homo sapiens	129-141
12149148-7	2002	The essential role of JNK in the induction of SCLC apoptosis with CDDP and anti-GD2 mAb was confirmed by experiments with a JNK inhibitor, curcumin.	Curcumin	139-147	mitogen-activated protein kinase 8	Homo sapiens	124-127
12055272-7	2002	In vitro treatment of activated T cells with curcumin inhibited IL-12-induced tyrosine phosphorylation of Janus kinase 2, tyrosine kinase 2, and STAT3 and STAT4 transcription factors.	Curcumin	45-53	signal transducer and activator of transcription 3	Mus musculus	145-150
12208119-6	2002	Intragastric administration of curcumin (80mg/kg body weight) and curcumin analog (80mg/kg body weight) to DMH-injected rats significantly reduced the number and size of tumour in the colon, lowered lipid peroxidation and enhanced the activities of GPx, GST, SOD and CAT in the liver.	Curcumin	31-39	catalase	Rattus norvegicus	267-270
12208119-6	2002	Intragastric administration of curcumin (80mg/kg body weight) and curcumin analog (80mg/kg body weight) to DMH-injected rats significantly reduced the number and size of tumour in the colon, lowered lipid peroxidation and enhanced the activities of GPx, GST, SOD and CAT in the liver.	Curcumin	66-74	catalase	Rattus norvegicus	267-270
12408761-3	2002	The effect of curcumin on the expression of c-myc, bcl-2, mutant-type p53 and Fas protein and mRNA was studied by flow cytometry (FCM) and reverse transcription-polymerase chain reaction (RT-PCR).	Curcumin	14-22	BCL2 apoptosis regulator	Homo sapiens	51-56
12408761-3	2002	The effect of curcumin on the expression of c-myc, bcl-2, mutant-type p53 and Fas protein and mRNA was studied by flow cytometry (FCM) and reverse transcription-polymerase chain reaction (RT-PCR).	Curcumin	14-22	tumor protein p53	Homo sapiens	70-73
12408761-8	2002	The expression of c-myc, bcl-2, mutant-type p53 protein and mRNA was decreased sharply in CA46 cells treated with curcumin, while Fas protein and mRNA was increased.	Curcumin	114-122	BCL2 apoptosis regulator	Homo sapiens	25-30
12408761-8	2002	The expression of c-myc, bcl-2, mutant-type p53 protein and mRNA was decreased sharply in CA46 cells treated with curcumin, while Fas protein and mRNA was increased.	Curcumin	114-122	tumor protein p53	Homo sapiens	44-47
12408761-9	2002	CONCLUSION: Curcumin is able to inhibit the proliferation of CA46 cells and induce the cell apoptosis by down-regulating the expression of c-myc, bcl-2, mutant-type p53 and up-regulating the expression of Fas.	Curcumin	12-20	BCL2 apoptosis regulator	Homo sapiens	146-151
12408761-9	2002	CONCLUSION: Curcumin is able to inhibit the proliferation of CA46 cells and induce the cell apoptosis by down-regulating the expression of c-myc, bcl-2, mutant-type p53 and up-regulating the expression of Fas.	Curcumin	12-20	tumor protein p53	Homo sapiens	165-168
12297018-4	2002	Alternatively, curcumin repressed the TPA-induced activation of NF-kappaB through direct interruption of the binding of NF-kappaB to its consensus DNA sequences.	Curcumin	15-23	nuclear factor kappa B subunit 1	Homo sapiens	64-73
12297018-0	2002	Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	34-43
12297018-0	2002	Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells.	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	48-52
11967955-0	2002	Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1/CIP1) and C/EBPbeta expressions and suppressing NF-kappaB activation.	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	95-98
11967955-0	2002	Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1/CIP1) and C/EBPbeta expressions and suppressing NF-kappaB activation.	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	99-103
11967955-0	2002	Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1/CIP1) and C/EBPbeta expressions and suppressing NF-kappaB activation.	Curcumin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	104-108
12297018-3	2002	In this study, we have found that curcumin inhibits the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced nuclear factor kB (NF-kappaB) activation by preventing the degradation of the inhibitory protein IkBalpa; and the subsequent translocation of the p65 subunit in cultured human promyelocytic leukemia (HL-60) cells.	Curcumin	34-42	nuclear factor kappa B subunit 1	Homo sapiens	126-135
12297018-4	2002	Alternatively, curcumin repressed the TPA-induced activation of NF-kappaB through direct interruption of the binding of NF-kappaB to its consensus DNA sequences.	Curcumin	15-23	nuclear factor kappa B subunit 1	Homo sapiens	120-129
12297018-5	2002	Likewise, the TPA-induced DNA binding of the activator protein-1 (AP-1) was inhibited by curcumin pretreatment.	Curcumin	89-97	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-64
12297018-5	2002	Likewise, the TPA-induced DNA binding of the activator protein-1 (AP-1) was inhibited by curcumin pretreatment.	Curcumin	89-97	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-70
12007574-0	2002	Basal levels and patterns of anticancer drug-induced activation of nuclear factor-kappaB (NF-kappaB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells.	Curcumin	155-163	nuclear factor kappa B subunit 1	Homo sapiens	67-88
12007574-0	2002	Basal levels and patterns of anticancer drug-induced activation of nuclear factor-kappaB (NF-kappaB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells.	Curcumin	155-163	nuclear factor kappa B subunit 1	Homo sapiens	90-99
12007574-7	2002	In particular, when cells were pretreated with common biologic modulators such as tamoxifen, dexamethasone, and curcumin, the doxorubicin-induced NF-kappaB activation was attenuated significantly.	Curcumin	112-120	nuclear factor kappa B subunit 1	Homo sapiens	146-155
12009331-7	2002	Inhibitor of JNK, AP-1 and NF-kappa B, curcumin, achieved 48-99% suppression of MMP-3 and 45-97% of MMP-13 in human and 8-100% (MMP-3) and 32-100% (MMP-13) in bovine chondrocytes.	Curcumin	39-47	matrix metallopeptidase 3	Homo sapiens	80-85
11999122-6	2002	A large number of compounds are currently known as NF-kappaB modulators and include the isoprenoids, most notably kaurene diterpenoids and members of the sesquiterpene lactones class, several phenolics including curcumin and flavonoids such as silybin.	Curcumin	212-220	nuclear factor kappa B subunit 1	Homo sapiens	51-60
12009331-7	2002	Inhibitor of JNK, AP-1 and NF-kappa B, curcumin, achieved 48-99% suppression of MMP-3 and 45-97% of MMP-13 in human and 8-100% (MMP-3) and 32-100% (MMP-13) in bovine chondrocytes.	Curcumin	39-47	matrix metallopeptidase 13	Homo sapiens	100-106
12009331-7	2002	Inhibitor of JNK, AP-1 and NF-kappa B, curcumin, achieved 48-99% suppression of MMP-3 and 45-97% of MMP-13 in human and 8-100% (MMP-3) and 32-100% (MMP-13) in bovine chondrocytes.	Curcumin	39-47	matrix metallopeptidase 3	Homo sapiens	128-133
12009331-7	2002	Inhibitor of JNK, AP-1 and NF-kappa B, curcumin, achieved 48-99% suppression of MMP-3 and 45-97% of MMP-13 in human and 8-100% (MMP-3) and 32-100% (MMP-13) in bovine chondrocytes.	Curcumin	39-47	mitogen-activated protein kinase 8	Homo sapiens	13-16
12009331-7	2002	Inhibitor of JNK, AP-1 and NF-kappa B, curcumin, achieved 48-99% suppression of MMP-3 and 45-97% of MMP-13 in human and 8-100% (MMP-3) and 32-100% (MMP-13) in bovine chondrocytes.	Curcumin	39-47	matrix metallopeptidase 13	Homo sapiens	148-154
12009331-7	2002	Inhibitor of JNK, AP-1 and NF-kappa B, curcumin, achieved 48-99% suppression of MMP-3 and 45-97% of MMP-13 in human and 8-100% (MMP-3) and 32-100% (MMP-13) in bovine chondrocytes.	Curcumin	39-47	nuclear factor kappa B subunit 1	Homo sapiens	27-37
11751895-7	2002	Similarly, a selective mitogen-activated protein kinase (MAPK) kinase (MEK)1/2 inhibitor (PD98059) and c-jun/activator protein (AP)-1 inhibitor (curcumin) suppressed MMP-13 mRNA up-regulation induced by MIF.	Curcumin	145-153	macrophage migration inhibitory factor	Rattus norvegicus	203-206
11857414-2	2002	Our experiments demonstrate that curcumin"s antiproliferative effects are estrogen dependent in ER (estrogen receptor)-positive MCF-7 cells, being more pronounced in estrogen-containing media and in the presence of exogenous 17-beta estradiol.	Curcumin	33-41	estrogen receptor 1	Homo sapiens	100-117
11857414-3	2002	Curcumin inhibits the expression of ER downstream genes including pS2 and TGF-beta (transforming growth factor) in ER-positive MCF-7 cells, and this inhibition is also dependent on the presence of estrogen.	Curcumin	0-8	trefoil factor 1	Homo sapiens	66-69
11857414-3	2002	Curcumin inhibits the expression of ER downstream genes including pS2 and TGF-beta (transforming growth factor) in ER-positive MCF-7 cells, and this inhibition is also dependent on the presence of estrogen.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	74-82
11857414-7	2002	Our study also demonstrates that curcumin inhibits the transcript levels of 2 major angiogenesis factors VEGF (vascular endothelial growth factor) and b-FGF (basic fibroblast growth factor) mainly in ER-negative MDA-MB-231 cells.	Curcumin	33-41	vascular endothelial growth factor A	Homo sapiens	105-109
11857414-7	2002	Our study also demonstrates that curcumin inhibits the transcript levels of 2 major angiogenesis factors VEGF (vascular endothelial growth factor) and b-FGF (basic fibroblast growth factor) mainly in ER-negative MDA-MB-231 cells.	Curcumin	33-41	vascular endothelial growth factor A	Homo sapiens	111-145
11857414-7	2002	Our study also demonstrates that curcumin inhibits the transcript levels of 2 major angiogenesis factors VEGF (vascular endothelial growth factor) and b-FGF (basic fibroblast growth factor) mainly in ER-negative MDA-MB-231 cells.	Curcumin	33-41	fibroblast growth factor 2	Homo sapiens	151-156
11857414-7	2002	Our study also demonstrates that curcumin inhibits the transcript levels of 2 major angiogenesis factors VEGF (vascular endothelial growth factor) and b-FGF (basic fibroblast growth factor) mainly in ER-negative MDA-MB-231 cells.	Curcumin	33-41	fibroblast growth factor 2	Homo sapiens	158-188
11870879-9	2002	Electrophoretic mobility shift assays (EMSA) showed that activator protein 1 (AP-1) binding to a cognate AP-1 sequence was detected at 6 h and could be blocked by curcumin.	Curcumin	163-171	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-76
11870879-9	2002	Electrophoretic mobility shift assays (EMSA) showed that activator protein 1 (AP-1) binding to a cognate AP-1 sequence was detected at 6 h and could be blocked by curcumin.	Curcumin	163-171	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	78-82
11870879-9	2002	Electrophoretic mobility shift assays (EMSA) showed that activator protein 1 (AP-1) binding to a cognate AP-1 sequence was detected at 6 h and could be blocked by curcumin.	Curcumin	163-171	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-109
14607648-10	2002	Antisense hTR appears to increase Pancl cell"s susceptibility to chemotherapeutic reagent cDDP, but not to differentiation reagent DMSO, COX2 inhibitor sulinbac, NS-398, curcumin, and chemotherapeutic reagent adriamycin (ADM).	Curcumin	170-178	telomerase RNA component	Homo sapiens	10-13
11852106-0	2002	Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction.	Curcumin	0-8	tumor protein p53	Homo sapiens	64-67
11852106-0	2002	Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	78-81
11852106-2	2002	From quantitative image analysis data showing an increase in the percentage of cells with a sub-G0/G1 DNA content, we demonstrated curcumin-induced apoptosis in the breast cancer cell line MCF-7, in which expression of wild-type p53 could be induced.	Curcumin	131-139	tumor protein p53	Homo sapiens	229-232
11852106-4	2002	Further experiments using p53-null MDAH041 cell as well as low and high p53-expressing TR9-7 cell, in which p53 expression is under tight control of tetracycline, established that curcumin induced apoptosis in tumor cells via a p53-dependent pathway in which Bax is the downstream effector of p53.	Curcumin	180-188	tumor protein p53	Homo sapiens	26-29
11852106-4	2002	Further experiments using p53-null MDAH041 cell as well as low and high p53-expressing TR9-7 cell, in which p53 expression is under tight control of tetracycline, established that curcumin induced apoptosis in tumor cells via a p53-dependent pathway in which Bax is the downstream effector of p53.	Curcumin	180-188	tumor protein p53	Homo sapiens	72-75
11852106-4	2002	Further experiments using p53-null MDAH041 cell as well as low and high p53-expressing TR9-7 cell, in which p53 expression is under tight control of tetracycline, established that curcumin induced apoptosis in tumor cells via a p53-dependent pathway in which Bax is the downstream effector of p53.	Curcumin	180-188	tumor protein p53	Homo sapiens	72-75
11852106-4	2002	Further experiments using p53-null MDAH041 cell as well as low and high p53-expressing TR9-7 cell, in which p53 expression is under tight control of tetracycline, established that curcumin induced apoptosis in tumor cells via a p53-dependent pathway in which Bax is the downstream effector of p53.	Curcumin	180-188	tumor protein p53	Homo sapiens	72-75
11852106-4	2002	Further experiments using p53-null MDAH041 cell as well as low and high p53-expressing TR9-7 cell, in which p53 expression is under tight control of tetracycline, established that curcumin induced apoptosis in tumor cells via a p53-dependent pathway in which Bax is the downstream effector of p53.	Curcumin	180-188	BCL2 associated X, apoptosis regulator	Homo sapiens	259-262
11852106-4	2002	Further experiments using p53-null MDAH041 cell as well as low and high p53-expressing TR9-7 cell, in which p53 expression is under tight control of tetracycline, established that curcumin induced apoptosis in tumor cells via a p53-dependent pathway in which Bax is the downstream effector of p53.	Curcumin	180-188	tumor protein p53	Homo sapiens	72-75
12171541-9	2002	Curcumin inhibits lipooxygenase activity and is a specific inhibitor of cyclooxygenase-2 expression.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	72-88
12515914-0	2002	Curcumin differentially regulates TGF-beta1, its receptors and nitric oxide synthase during impaired wound healing.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	34-43
12515914-7	2002	Curcumin treatment resulted in the enhanced expression of TGF-beta1 and TGF-beta tIIrc in both normal and impaired healing wounds as revealed by immunohistochemistry.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	58-67
11756235-0	2002	Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.	Curcumin	0-8	BH3 interacting domain death agonist	Homo sapiens	80-83
11756235-0	2002	Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	97-109
11756235-0	2002	Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	160-165
11756235-0	2002	Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.	Curcumin	0-8	BCL2 like 1	Homo sapiens	170-176
11756235-0	2002	Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.	Curcumin	10-27	BH3 interacting domain death agonist	Homo sapiens	80-83
11756235-0	2002	Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.	Curcumin	10-27	cytochrome c, somatic	Homo sapiens	97-109
11756235-0	2002	Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.	Curcumin	10-27	BCL2 apoptosis regulator	Homo sapiens	160-165
11756235-0	2002	Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.	Curcumin	10-27	BCL2 like 1	Homo sapiens	170-176
11756235-3	2002	The apoptotic intermediates through which curcumin exhibits its cytotoxic effects against tumor cells are not known, and the participation of antiapoptotic proteins Bcl-2 or Bcl-xl in the curcumin-induced apoptosis pathway is not established.	Curcumin	188-196	BCL2 apoptosis regulator	Homo sapiens	165-170
11756235-3	2002	The apoptotic intermediates through which curcumin exhibits its cytotoxic effects against tumor cells are not known, and the participation of antiapoptotic proteins Bcl-2 or Bcl-xl in the curcumin-induced apoptosis pathway is not established.	Curcumin	188-196	BCL2 like 1	Homo sapiens	174-180
11756235-7	2002	Similarly, time-dependent poly(ADP)ribose polymerase (PARP) cleavage by curcumin was observed in neo cells but not in Bcl-2 and Bcl-xl-transfected cells.	Curcumin	72-80	poly(ADP-ribose) polymerase 1	Homo sapiens	26-52
11756235-7	2002	Similarly, time-dependent poly(ADP)ribose polymerase (PARP) cleavage by curcumin was observed in neo cells but not in Bcl-2 and Bcl-xl-transfected cells.	Curcumin	72-80	poly(ADP-ribose) polymerase 1	Homo sapiens	54-58
11756235-8	2002	Curcumin treatment also induced BID cleavage and mitochondrial cytochrome c release in neo cells but not in Bcl-2 and Bcl-xl-transfected cells.	Curcumin	0-8	BH3 interacting domain death agonist	Homo sapiens	32-35
11756235-8	2002	Curcumin treatment also induced BID cleavage and mitochondrial cytochrome c release in neo cells but not in Bcl-2 and Bcl-xl-transfected cells.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	63-75
11756235-9	2002	In neo HL-60 cells, curcumin also downregulated the expression of cyclooxygenase-2.	Curcumin	20-28	prostaglandin-endoperoxide synthase 2	Homo sapiens	66-82
11756235-11	2002	Overall, our results indicate that curcumin induces apoptosis through mitochondrial pathway involving caspase-8, BID cleavage, cytochrome c release, and caspase-3 activation.	Curcumin	35-43	BH3 interacting domain death agonist	Homo sapiens	113-116
11756235-11	2002	Overall, our results indicate that curcumin induces apoptosis through mitochondrial pathway involving caspase-8, BID cleavage, cytochrome c release, and caspase-3 activation.	Curcumin	35-43	cytochrome c, somatic	Homo sapiens	127-139
11756235-11	2002	Overall, our results indicate that curcumin induces apoptosis through mitochondrial pathway involving caspase-8, BID cleavage, cytochrome c release, and caspase-3 activation.	Curcumin	35-43	caspase 3	Homo sapiens	153-162
11756235-12	2002	Our results also suggest that Bcl-2 and Bcl-xl are critical negative regulators of curcumin-induced apoptosis.	Curcumin	83-91	BCL2 apoptosis regulator	Homo sapiens	30-35
11756235-12	2002	Our results also suggest that Bcl-2 and Bcl-xl are critical negative regulators of curcumin-induced apoptosis.	Curcumin	83-91	BCL2 like 1	Homo sapiens	40-46
12515914-7	2002	Curcumin treatment resulted in the enhanced expression of TGF-beta1 and TGF-beta tIIrc in both normal and impaired healing wounds as revealed by immunohistochemistry.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	58-66
12515914-8	2002	Macrophages in the wound bed showed an enhanced expression of TGF-beta1 mRNA in curcumin treated wounds as evidenced by in situ hybridization.	Curcumin	80-88	transforming growth factor, beta 1	Rattus norvegicus	62-71
12515914-9	2002	However, enhanced expression of TGF-beta tIrc by curcumin treatment observed only in dexamethasone-impaired wounds at the 7th day post-wounding.	Curcumin	49-57	transforming growth factor, beta 1	Rattus norvegicus	32-40
12515914-10	2002	iNOS levels were increased following curcumin treatment in unimpaired wounds, but not so in the dexamethasone-impaired wounds.	Curcumin	37-45	nitric oxide synthase 2	Rattus norvegicus	0-4
12674762-4	2002	It was found that when HL-60 cells were treated with 25 mumol/L curcumin for 24 h, the expression level of Mcl-1 was down-regulated, but that of Bax and Bak up-regulated time-dependently.	Curcumin	64-72	BCL2 associated X, apoptosis regulator	Homo sapiens	145-148
12086402-6	2002	Naturally occurring COX-2 inhibitors such as curcumin and certain phytosterols have been proven to be effective as chemopreventive agents against colon carcinogenesis with minimal gastrointestinal toxicity.	Curcumin	45-53	prostaglandin-endoperoxide synthase 2	Homo sapiens	20-25
12674762-1	2002	To investigate whether the Bcl-2 gene family is involved in modulating mechanism of apoptosis and change of cell cycle protein induced by curcumin in acute myeloid leukemia HL-60 cell line and primary acute myelogenous leukemic cells, the Bcl-2 family member Mcl-1, Bax and Bak and cell cycle proteins including P27kipl, P21wafl, cyclin D3 and pRbp- were selected and their expression detected by SABC immuno-histochemical stain method.	Curcumin	138-146	BCL2 apoptosis regulator	Homo sapiens	27-32
12674762-5	2002	There was significant difference in the expression level of Mcl-1, Bax and Bak between the curcumin-treated groups and control group (P &lt; 0.05-0.01).	Curcumin	91-99	BCL2 associated X, apoptosis regulator	Homo sapiens	67-70
12674762-6	2002	At the same time, curcumin had no effect on progress of cell cycle in primaty acute myelogenous leukemia at newly diagnosis, but could increase the peak of Sub-G1 (P &lt; 0.05), and down-regulate the expression of Mcl-1 and up-regulate the expression of Bax and Bak with the difference being statistically significant.	Curcumin	18-26	BCL2 associated X, apoptosis regulator	Homo sapiens	254-257
12674762-7	2002	The expression of P27kipl, P21wafl and pRbp- were elevated and that of cyclin D3 decreased in the presence of curcumin.	Curcumin	110-118	cyclin D3	Homo sapiens	71-80
12674762-8	2002	These findings suggested that the Bcl-2 gene family indeed participated in the regulatory process of apoptosis induced by curcumin in HL-60 cells and AML cells.	Curcumin	122-130	BCL2 apoptosis regulator	Homo sapiens	34-39
11716543-2	2001	We found that curcumin caused cell death in eight melanoma cell lines, four with wild-type and four with mutant p53.	Curcumin	14-22	tumor protein p53	Homo sapiens	112-115
11795492-6	2001	Pretreatment of JNK specific inhibitors, curcumin and all trans-retinoic acid, decreased the basal motility of DAR-ECV cells in a dose-dependent manner.	Curcumin	41-49	mitogen-activated protein kinase 8	Homo sapiens	16-19
11716543-10	2001	Since melanoma cells with mutant p53 are strongly resistant to conventional chemotherapy, curcumin may overcome the chemoresistance of these cells and provide potential new avenues for treatment.	Curcumin	90-98	tumor protein p53	Homo sapiens	33-36
11751448-2	2001	Curcumin, a polyphenol derived from Curcuma spp., has shown wide-ranging chemopreventive activity in preclinical carcinogenic models, in which it inhibits cyclooxygenase (COX)-2 at the transcriptional level.	Curcumin	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	155-177
12005259-9	2001	Curcumin produced significant inhibition of IL-1beta and IL-8 but minimal inhibition of TNFalpha expression by preterm lung inflammatory cells at 20 uM concentrations.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	44-52
12005259-9	2001	Curcumin produced significant inhibition of IL-1beta and IL-8 but minimal inhibition of TNFalpha expression by preterm lung inflammatory cells at 20 uM concentrations.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
12005259-10	2001	Adult PBMC expression of IL-8 was significantly inhibited by curcumin at 20 uM concentrations.	Curcumin	61-69	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
12005259-11	2001	Therefore, curcumin inhibits pro-inflammatory cytokine production (TNFalpha, IL-1beta and IL-8) by lung inflammatory cells ex vivo.	Curcumin	11-19	tumor necrosis factor	Homo sapiens	67-75
12005259-11	2001	Therefore, curcumin inhibits pro-inflammatory cytokine production (TNFalpha, IL-1beta and IL-8) by lung inflammatory cells ex vivo.	Curcumin	11-19	interleukin 1 beta	Homo sapiens	77-85
12005259-11	2001	Therefore, curcumin inhibits pro-inflammatory cytokine production (TNFalpha, IL-1beta and IL-8) by lung inflammatory cells ex vivo.	Curcumin	11-19	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
11751448-5	2001	When 1 microM curcumin was added in vitro to blood from healthy volunteers, LPS-induced COX-2 protein levels and concomitant PGE(2) production were reduced by 24% and 41%, respectively (P &lt; 0.05 by ANOVA).	Curcumin	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
11606625-7	2001	Low and high doses of curcumin significantly lowered oxidized proteins and interleukin-1beta, a proinflammatory cytokine elevated in the brains of these mice.	Curcumin	22-30	interleukin 1 beta	Mus musculus	75-92
11676493-6	2001	The status of Bcl-2 remains unchanged in EAC, which would signify that curcumin is bypassing the Bcl-2 checkpoint and overriding its protective effect on apoptosis.	Curcumin	71-79	B cell leukemia/lymphoma 2	Mus musculus	97-102
11731421-6	2001	Inhibition of CSN kinase activity by 50 microM curcumin for 2 h decreases the cellular c-Jun concentration, resulting in a reduction of the VEGF production by approximately 75%.	Curcumin	47-55	vascular endothelial growth factor A	Homo sapiens	140-144
11733029-5	2001	For the skeletal muscle isoform of the Ca2+ pump (SERCA1), the inhibition of curcumin is noncompetitive with respect to Ca2+, and competitive with respect to ATP at high curcumin concentrations ( approximately 10-25 microm).	Curcumin	77-85	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	50-56
11733029-5	2001	For the skeletal muscle isoform of the Ca2+ pump (SERCA1), the inhibition of curcumin is noncompetitive with respect to Ca2+, and competitive with respect to ATP at high curcumin concentrations ( approximately 10-25 microm).	Curcumin	170-178	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	50-56
11753638-8	2001	Treatment of cells with curcumin, a chemopreventive agent, suppressed both constitutive (DU145) and inducible (LNCaP) NF-kappaB activation, and potentiated TNF-induced apoptosis.	Curcumin	24-32	nuclear factor kappa B subunit 1	Homo sapiens	118-127
11753638-8	2001	Treatment of cells with curcumin, a chemopreventive agent, suppressed both constitutive (DU145) and inducible (LNCaP) NF-kappaB activation, and potentiated TNF-induced apoptosis.	Curcumin	24-32	tumor necrosis factor	Homo sapiens	156-159
11753638-9	2001	Curcumin alone induced apoptosis in both cell types, which correlated with the downregulation of the expression of Bcl-2 and Bcl-xL and the activation of procaspase-3 and procaspase-8.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	115-120
11753638-9	2001	Curcumin alone induced apoptosis in both cell types, which correlated with the downregulation of the expression of Bcl-2 and Bcl-xL and the activation of procaspase-3 and procaspase-8.	Curcumin	0-8	BCL2 like 1	Homo sapiens	125-131
11753638-9	2001	Curcumin alone induced apoptosis in both cell types, which correlated with the downregulation of the expression of Bcl-2 and Bcl-xL and the activation of procaspase-3 and procaspase-8.	Curcumin	0-8	caspase 3	Homo sapiens	154-166
11592943-4	2001	To elucidate the molecular mechanism of HO-1 induction, we examined the effects of diferuloylmethane (curcumin), an inhibitor of the transcription factor AP-1.	Curcumin	83-100	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	154-158
11592943-4	2001	To elucidate the molecular mechanism of HO-1 induction, we examined the effects of diferuloylmethane (curcumin), an inhibitor of the transcription factor AP-1.	Curcumin	102-110	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	154-158
11592943-10	2001	Blockade of nuclear factor-kappaB (NF-kappaB) with an IkappaBalpha phosphorylation inhibitor attenuated curcumin-mediated induction of HO-1 mRNA and protein.	Curcumin	104-112	nuclear factor kappa B subunit 1	Homo sapiens	12-33
11592943-10	2001	Blockade of nuclear factor-kappaB (NF-kappaB) with an IkappaBalpha phosphorylation inhibitor attenuated curcumin-mediated induction of HO-1 mRNA and protein.	Curcumin	104-112	nuclear factor kappa B subunit 1	Homo sapiens	35-44
11592943-12	2001	HO-1 induction by curcumin is mediated, at least in part, via transcriptional mechanisms and involves the NF-kappaB pathway.	Curcumin	18-26	nuclear factor kappa B subunit 1	Homo sapiens	106-115
11747626-7	2001	Furthermore, LPS-induced IL-6 synthesis was inhibited by curcumin (an inhibitor of activating protein-1 [AP-1]) but not by pyrrolidine dithiocarbamate (PDTC) (an inhibitor of nuclear factor kappa B [NF-kappaB]).	Curcumin	57-65	interleukin 6	Homo sapiens	25-29
11566484-0	2001	Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells.	Curcumin	70-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	23-39
11544338-6	2001	Curcumin also blocked isopentenyl pyrophosphate-induced activation of NF-kappaB and AP-1.	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	84-88
11566484-0	2001	Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells.	Curcumin	70-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	41-46
11566484-3	2001	To investigate the effect of curcumin on COX-2 expression, we treated HT-29 human colon cancer cells with various concentrations of curcumin.	Curcumin	29-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	41-46
11566484-5	2001	Curcumin markedly inhibited the mRNA and protein expression of COX-2, but not COX-1.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	63-68
11566484-6	2001	These data suggest that a non-toxic concentration of curcumin has a significant effect on the in vitro growth of HT-29 cells, specifically inhibits COX-2 expression, and may have value as a safe chemopreventive agent for colon cancer.	Curcumin	53-61	prostaglandin-endoperoxide synthase 2	Homo sapiens	148-153
11402024-6	2001	Interestingly, staurosporin and curcumin are also shown to provoke the degradation of ErbB-2 with formation of the 23-kDa carboxyl-terminal fragment.	Curcumin	32-40	erb-b2 receptor tyrosine kinase 2	Homo sapiens	86-92
11522452-0	2001	Effect of glutathione depletion on caspase-3 independent apoptosis pathway induced by curcumin in Jurkat cells.	Curcumin	86-94	caspase 3	Homo sapiens	35-44
11686235-4	2001	The expression of hsp 70 was also seen upon 8 h of curcumin treatment, and it remained constant up to 48 h. Differentiated cells also expressed a series of differentiation markers such as lamin A, well-established actin, and keratin cytoskeleton.	Curcumin	51-59	heat shock protein 1B	Mus musculus	18-24
11522452-3	2001	Previously, we showed that in Jurkat cells curcumin induced nontypical apoptosis-like pathway, which was independent of mitochondria and caspase-3.	Curcumin	43-51	caspase 3	Homo sapiens	137-146
11522452-4	2001	Now we show that the inhibition of caspase-3 by curcumin, which is accompanied by attenuation of internucleosomal DNA fragmentation, may be due to elevation of glutathione, which increased in curcumin-treated cells to 130% of control.	Curcumin	48-56	caspase 3	Homo sapiens	35-44
11522452-4	2001	Now we show that the inhibition of caspase-3 by curcumin, which is accompanied by attenuation of internucleosomal DNA fragmentation, may be due to elevation of glutathione, which increased in curcumin-treated cells to 130% of control.	Curcumin	192-200	caspase 3	Homo sapiens	35-44
11522452-5	2001	We have demonstrated that glutathione depletion does not itself induce apoptosis in Jurkat cells; though, it can release cytochrome c from mitochondria and caspase-3 from inhibition by curcumin, as shown by Western blot.	Curcumin	185-193	cytochrome c, somatic	Homo sapiens	121-133
11522452-5	2001	We have demonstrated that glutathione depletion does not itself induce apoptosis in Jurkat cells; though, it can release cytochrome c from mitochondria and caspase-3 from inhibition by curcumin, as shown by Western blot.	Curcumin	185-193	caspase 3	Homo sapiens	156-165
11522452-6	2001	The level of Bcl-2 protein was not affected by glutathione depletion even upon curcumin treatment.	Curcumin	79-87	BCL2 apoptosis regulator	Homo sapiens	13-18
11522452-7	2001	Altogether, our results show that in Jurkat cells curcumin prevents glutathione decrease, thus protecting cells against caspase-3 activation and oligonucleosomal DNA fragmentation.	Curcumin	50-58	caspase 3	Homo sapiens	120-129
11053056-6	2000	Furthermore, treatment with either PD098059, SB203580, or the JNK-AP-1 inhibitor curcumin diminished the expression of MCP-1 and stromelysin.	Curcumin	81-89	mitogen-activated protein kinase 8	Homo sapiens	62-65
11425486-6	2001	Curcumin and SB203580, which inhibit JNK and p38 MAPK signaling pathways, but not herbimycin A/staurosporine, prevented the MGO-induced PARP degradation.	Curcumin	0-8	mitogen-activated protein kinase 1	Homo sapiens	45-48
11425486-6	2001	Curcumin and SB203580, which inhibit JNK and p38 MAPK signaling pathways, but not herbimycin A/staurosporine, prevented the MGO-induced PARP degradation.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	49-53
11425486-6	2001	Curcumin and SB203580, which inhibit JNK and p38 MAPK signaling pathways, but not herbimycin A/staurosporine, prevented the MGO-induced PARP degradation.	Curcumin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	136-140
11351295-6	2001	The GST inhibitor curcumin also enhanced cytotoxicity in HEp2A cells when the Pgp/MRP efflux barrier had been reversed by verapamil or overcome by high doxorubicin concentrations.	Curcumin	18-26	ATP binding cassette subfamily B member 1	Homo sapiens	78-81
11351295-6	2001	The GST inhibitor curcumin also enhanced cytotoxicity in HEp2A cells when the Pgp/MRP efflux barrier had been reversed by verapamil or overcome by high doxorubicin concentrations.	Curcumin	18-26	ATP binding cassette subfamily C member 1	Homo sapiens	82-85
11396485-8	2001	Of the five antioxidants tested, only curcumin was able to inhibit IkappaBalpha degradation upstream and, hence, NF-kappaB DNA-binding activity and NF-kappaB-dependent expression of IL-6 downstream.	Curcumin	38-46	NFKB inhibitor alpha	Homo sapiens	67-79
11396485-8	2001	Of the five antioxidants tested, only curcumin was able to inhibit IkappaBalpha degradation upstream and, hence, NF-kappaB DNA-binding activity and NF-kappaB-dependent expression of IL-6 downstream.	Curcumin	38-46	interleukin 6	Homo sapiens	182-186
11370761-6	2001	In addition, curcumin inhibits the activation of NFkappaB and the expression of c-jun, c-fos, c-myc and iNOS.	Curcumin	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-57
11370761-6	2001	In addition, curcumin inhibits the activation of NFkappaB and the expression of c-jun, c-fos, c-myc and iNOS.	Curcumin	13-21	nitric oxide synthase 2, inducible	Mus musculus	104-108
11678207-3	2001	The tyrosine kinase inhibitor genistein and AP-1 inhibitor curcumin significantly blocked TGF-beta induction of VEGF expression while SP-1 and MKK1 inhibitors did not.	Curcumin	59-67	transforming growth factor beta 1	Homo sapiens	90-98
11678207-3	2001	The tyrosine kinase inhibitor genistein and AP-1 inhibitor curcumin significantly blocked TGF-beta induction of VEGF expression while SP-1 and MKK1 inhibitors did not.	Curcumin	59-67	vascular endothelial growth factor A	Homo sapiens	112-116
11077049-0	2000	Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IkappaB kinase and NFkappaB activation in macrophages.	Curcumin	67-75	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	155-163
11077049-3	2000	Western blotting and northern blotting analyses demonstrated that curcumin strongly reduced 130-kDa protein and 4.5-kb mRNA levels of iNOS in LPS-activated macrophages compared with its metabolites, tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin.	Curcumin	66-74	nitric oxide synthase 2, inducible	Mus musculus	134-138
11077049-4	2000	Moreover, electrophoretic mobility shift assay (EMSA) experiments indicated that curcumin blocked the LPS-induced binding of nuclear factor-kappaB (NFkappaB), a transcription factor necessary for iNOS induction to its (32)P-labeled double-stranded oligonucleotide probe.	Curcumin	81-89	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-146
11077049-4	2000	Moreover, electrophoretic mobility shift assay (EMSA) experiments indicated that curcumin blocked the LPS-induced binding of nuclear factor-kappaB (NFkappaB), a transcription factor necessary for iNOS induction to its (32)P-labeled double-stranded oligonucleotide probe.	Curcumin	81-89	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	148-156
11077049-4	2000	Moreover, electrophoretic mobility shift assay (EMSA) experiments indicated that curcumin blocked the LPS-induced binding of nuclear factor-kappaB (NFkappaB), a transcription factor necessary for iNOS induction to its (32)P-labeled double-stranded oligonucleotide probe.	Curcumin	81-89	nitric oxide synthase 2, inducible	Mus musculus	196-200
11077049-6	2000	Transient transfection experiments also showed that curcumin inhibited NFkappaB-dependent transcriptional activity.	Curcumin	52-60	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-79
11077049-7	2000	Curcumin blocked the disappearance of inhibitory kappaBalpha (IkappaBalpha) and p65 from the cytosolic fraction, and inhibited the phosphorylation of IkappaBalpha.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	62-74
11077049-7	2000	Curcumin blocked the disappearance of inhibitory kappaBalpha (IkappaBalpha) and p65 from the cytosolic fraction, and inhibited the phosphorylation of IkappaBalpha.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	150-162
11077049-9	2000	These results suggest that curcumin may exert its anti-inflammatory and anti-carcinogenic properties by suppressing the activation of NFkappaB through inhibition of IKK activity.	Curcumin	27-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	134-142
11530010-3	2001	HB-EGF induction was blocked by curcumin, a c-jun/fos antisense oligonucleotide and a dominant-negative mutant of JNK1.	Curcumin	32-40	heparin-binding EGF-like growth factor	Rattus norvegicus	0-6
11534770-5	2001	Curcumin-induced cell death was mainly due to apoptosis in which a prominent downregulation of Bcl-2 and upregulation of Bax were involved.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	95-100
11534770-5	2001	Curcumin-induced cell death was mainly due to apoptosis in which a prominent downregulation of Bcl-2 and upregulation of Bax were involved.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	121-124
11534770-6	2001	We also suggest a possible involvement of caspase-3 in curcumin-induced apoptosis.	Curcumin	55-63	caspase 3	Homo sapiens	42-51
11422736-14	2001	Curcumin, an inhibitor of AP-1, dose-dependently suppressed the induction of MCP-1 mRNA by high glucose.	Curcumin	0-8	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	26-30
11285227-7	2001	Curcumin, a CSN kinase inhibitor, blocks E6-dependent p53 degradation in reticulocyte lysates.	Curcumin	0-8	tumor protein p53	Homo sapiens	54-57
11396178-5	2001	In both cell lines, immunoblot analysis indicated that curcumin caused induction of apoptosis as evidenced by cleavage of PARP, caspase-3, and reduction in Bcl-XL levels.	Curcumin	55-63	caspase 3	Homo sapiens	128-137
11396178-5	2001	In both cell lines, immunoblot analysis indicated that curcumin caused induction of apoptosis as evidenced by cleavage of PARP, caspase-3, and reduction in Bcl-XL levels.	Curcumin	55-63	BCL2 like 1	Homo sapiens	156-162
11312881-0	2001	Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells.	Curcumin	39-47	cytochrome c, somatic	Homo sapiens	56-68
11312881-0	2001	Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells.	Curcumin	39-47	caspase 1	Homo sapiens	95-103
11207308-8	2001	Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.	Curcumin	11-19	mitogen-activated protein kinase 3	Homo sapiens	224-230
11207308-8	2001	Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.	Curcumin	11-19	mitogen-activated protein kinase 1	Homo sapiens	236-239
11207308-8	2001	Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.	Curcumin	21-38	mitogen-activated protein kinase 3	Homo sapiens	224-230
11207308-8	2001	Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.	Curcumin	21-38	mitogen-activated protein kinase 1	Homo sapiens	236-239
11207308-9	2001	Curcumin also inhibited OSM-induced MMP-1, MMP-3, MMP-13, and TIMP-3 gene expression.	Curcumin	0-8	matrix metallopeptidase 3	Homo sapiens	43-48
11207308-9	2001	Curcumin also inhibited OSM-induced MMP-1, MMP-3, MMP-13, and TIMP-3 gene expression.	Curcumin	0-8	matrix metallopeptidase 13	Homo sapiens	50-56
11069500-8	2000	Decreased PhK activity in curcumin-and calcipotriol-treated psoriasis was associated with corresponding decreases in keratinocyte transferrin receptor (TRR) expression, severity of parakeratosis and density of epidermal CD8+ T cells.	Curcumin	26-34	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	10-13
10988260-9	2000	This increase of c-fos mRNA expression was blocked by PD98059; in addition, curcumin, a blocker of the transcriptional factor AP-1, canceled the effect of Ang II on the collagen I gene.	Curcumin	76-84	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	155-161
11029517-3	2000	Recently it was shown that the soybean lipoxygenase L1 catalyzed the oxygenation of curcumin and that curcumin can act as a lipoxygenase substrate.	Curcumin	84-92	seed linoleate 13S-lipoxygenase-1	Glycine max	39-54
11020339-14	2000	Curcumin (100 microM) obviously suppressed the iNOS expression in the mammary glands cultured with LPS, and a recovery in the eNOS expression was observed.	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	47-51
11020339-16	2000	These results indicate that curcumin has the ability to inhibit iNOS induction by LPS in the mammary gland and to scavenge NO radicals, which might explain, at least partly, its therapeutic properties in inflammation of the mammary gland.	Curcumin	28-36	nitric oxide synthase 2	Rattus norvegicus	64-68
11057875-10	2000	Pretreatment of HUVECs with curcumin, an inhibitor of NF-kappaB/Rel activation, synthesis of c-Jun mRNA and binding of activated AP- I with AP-binding oligonucleotide, prevented the VT-1 induced increase in TF mRNA and activity in VT-1-stimulated HUVECs.	Curcumin	28-36	nuclear factor kappa B subunit 1	Homo sapiens	54-63
11057875-11	2000	Curcumin also inhibited NF-kappaB and AP-1 binding to TF-kappaB and proximal TF-AP-1 oligonucleotides, respectively, in a dose-dependent manner.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	24-33
10991907-7	2000	Furthermore, curcumin remarkably suppressed the BLM-induced alveolar macrophage production of TNF-alpha, superoxide and nitric oxide.	Curcumin	13-21	tumor necrosis factor	Rattus norvegicus	94-103
10972672-8	2000	Pretreatment with MAP kinase kinase inhibitor PD098059 or JNK-c-Jun/AP-1 inhibitor curcumin attenuated the H2O2-induced apoptosis.	Curcumin	83-91	mitogen-activated protein kinase 8	Homo sapiens	58-61
10747850-4	2000	Signal-induced activation of NF-kappaB is known to be inhibited by curcumin.	Curcumin	67-75	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	29-38
10964761-6	2000	Cotreatment with PDTC and curcumin reduced particle-elicited IL-8 response, whereas cycloheximide caused enhancement of IL-8 mRNA expression in both the quartz- and TiO(2)-treated cells.	Curcumin	26-34	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
11023281-8	2000	The AP-1 inhibitor curcumin strongly inhibited VEGF-induced alkaline phosphatase production in human dental pulp cells.	Curcumin	19-27	vascular endothelial growth factor A	Homo sapiens	47-51
11360674-6	2000	Hirudin, curcumin, and c-fos antisense oligonucleotides could block thrombin-induced expression of MMP-9 mRNA as well as AP-1 binding activity.	Curcumin	9-17	coagulation factor II, thrombin	Homo sapiens	68-76
11775869-7	2000	Curcumin (AP-1 inhibitor), staurosporine (PKC inhibitor), and genistein (PTK inhibitor) all reduced AP-1-mediated PAI-1 mRNA expression induced by thrombin in cultured MCs.	Curcumin	0-8	coagulation factor II, thrombin	Homo sapiens	147-155
10747850-7	2000	When a super-repressor form of IkappaB-alpha (known to inhibit NF-kappaB) was transfected transiently into relA-transfected cells, the cells were no longer resistant to curcumin.	Curcumin	169-177	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	31-44
10747850-8	2000	Our results highlight a critical anti-apoptotic role for NF-kappaB in curcumin-induced apoptosis.	Curcumin	70-78	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-66
10813555-4	2000	In rats with acute liver injury, curcumin (100 and 200 mg kg(-1)) lowered the activity of serum alanine aminotransferase to 52-53% (P &lt; 0.05) and aspartate aminotransferase to about 62% (P &lt; 0.05) those of control rats.	Curcumin	33-41	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	149-175
10851300-2	2000	Curcumin inhibits tyrosine kinase activity of epidermal growth factor receptor and depletes the protein.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	46-78
10851300-3	2000	PURPOSE: In a search for alternative and preventive therapies for prostate cancer, attention was focused on the ways in which curcumin (Turmeric), used in food and medicine in India for centuries, could interfere with the growth factor signaling pathways in both androgen-dependent and androgen-independent prostate cancer cells, as exemplified by the epidermal growth factor receptor (EGF-R) signaling.	Curcumin	126-134	epidermal growth factor receptor	Homo sapiens	352-384
10851300-3	2000	PURPOSE: In a search for alternative and preventive therapies for prostate cancer, attention was focused on the ways in which curcumin (Turmeric), used in food and medicine in India for centuries, could interfere with the growth factor signaling pathways in both androgen-dependent and androgen-independent prostate cancer cells, as exemplified by the epidermal growth factor receptor (EGF-R) signaling.	Curcumin	126-134	epidermal growth factor receptor	Homo sapiens	386-391
10723098-5	2000	Inhibition of JNK activity by a JNK inhibitor, curcumin, remarkably reduced MG-induced caspase-3 activation, PARP cleavage, and apoptosis.	Curcumin	47-55	mitogen-activated protein kinase 8	Homo sapiens	14-17
10723098-5	2000	Inhibition of JNK activity by a JNK inhibitor, curcumin, remarkably reduced MG-induced caspase-3 activation, PARP cleavage, and apoptosis.	Curcumin	47-55	mitogen-activated protein kinase 8	Homo sapiens	32-35
10723098-5	2000	Inhibition of JNK activity by a JNK inhibitor, curcumin, remarkably reduced MG-induced caspase-3 activation, PARP cleavage, and apoptosis.	Curcumin	47-55	caspase 3	Homo sapiens	87-96
10723098-5	2000	Inhibition of JNK activity by a JNK inhibitor, curcumin, remarkably reduced MG-induced caspase-3 activation, PARP cleavage, and apoptosis.	Curcumin	47-55	poly(ADP-ribose) polymerase 1	Homo sapiens	109-113
10580329-2	1999	Curcumin interaction with human serum albumin (HSA) has been followed by fluorescence quenching and circular dichroism (CD) measurements.	Curcumin	0-8	albumin	Homo sapiens	47-50
11216470-0	2000	Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappaB and AP-1.	Curcumin	22-30	nuclear factor kappa B subunit 1	Homo sapiens	118-127
11216470-0	2000	Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappaB and AP-1.	Curcumin	22-30	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-136
11216470-9	2000	Based on these findings, it is likely that curcumin and capsaicin exert anti-tumor promotional effects through suppression of the tumor promoter-induced activation of transcription factors, NF-kappaB and AP-1.	Curcumin	43-51	nuclear factor kappa B subunit 1	Homo sapiens	190-199
11216470-9	2000	Based on these findings, it is likely that curcumin and capsaicin exert anti-tumor promotional effects through suppression of the tumor promoter-induced activation of transcription factors, NF-kappaB and AP-1.	Curcumin	43-51	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	204-208
10570055-9	1999	4-HPR-induced apoptosis in LNCaP cells was suppressed by curcumin, which inhibits JNK activation.	Curcumin	57-65	mitogen-activated protein kinase 8	Homo sapiens	82-85
10527691-0	1999	Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53.	Curcumin	0-8	BCL2 like 1	Homo sapiens	102-108
10527691-0	1999	Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	110-120
10527691-0	1999	Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53.	Curcumin	0-8	tumor protein p53	Homo sapiens	126-129
10527691-5	1999	Furthermore, curcumin downregulated the expression of survival genes egr-1, c-myc, and bcl-X(L) as well as the tumor suppressor gene p53 in B cells.	Curcumin	13-21	BCL2 like 1	Homo sapiens	87-95
10527691-5	1999	Furthermore, curcumin downregulated the expression of survival genes egr-1, c-myc, and bcl-X(L) as well as the tumor suppressor gene p53 in B cells.	Curcumin	13-21	tumor protein p53	Homo sapiens	133-136
10576620-2	1999	We demonstrate here that out of three compounds, viz diferuloylmethane, p-coumaroylferuloylmethane and di-p-coumaroylmethane, present in the ethyl acetate extract of Curcuma longa, diferuloylmethane is most potent in inhibiting TNF-alpha induced expression of ICAM-1, VCAM-1 and E-selectin on human umbilical vein endothelial cells.	Curcumin	181-198	tumor necrosis factor	Homo sapiens	228-237
10576620-2	1999	We demonstrate here that out of three compounds, viz diferuloylmethane, p-coumaroylferuloylmethane and di-p-coumaroylmethane, present in the ethyl acetate extract of Curcuma longa, diferuloylmethane is most potent in inhibiting TNF-alpha induced expression of ICAM-1, VCAM-1 and E-selectin on human umbilical vein endothelial cells.	Curcumin	181-198	vascular cell adhesion molecule 1	Homo sapiens	268-274
10576620-5	1999	As diferuloylmethane significantly blocks the cytokine induced transcript levels for the leukocyte adhesion molecules, it may be interfering at an early stage of signalling event induced by TNF-alpha.	Curcumin	3-20	tumor necrosis factor	Homo sapiens	190-199
10557090-0	1999	Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex.	Curcumin	87-95	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-31
10557090-0	1999	Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex.	Curcumin	87-95	nuclear factor kappa B subunit 1	Homo sapiens	119-128
10557090-7	1999	Since curcumin inhibits NF-kappaB activation, we examined whether its chemopreventive activity is related to modulation of the signalling pathway which regulates the stability of the NF-kappaB-sequestering protein, IkappaB.	Curcumin	6-14	nuclear factor kappa B subunit 1	Homo sapiens	24-33
11237176-5	2000	Subsequently, curcumin inhibits the activation of NFkappaB and the expressions of c-jun, c-fos, c-myc and iNOS.	Curcumin	14-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	50-58
11237176-5	2000	Subsequently, curcumin inhibits the activation of NFkappaB and the expressions of c-jun, c-fos, c-myc and iNOS.	Curcumin	14-22	nitric oxide synthase 2, inducible	Mus musculus	106-110
11688958-6	2000	The downregulation of transcriptional AP-1 activity by curcumin as seen in the dual luciferase assay caused inhibition of LLC cell invasion through the repression of expression of the mRNAs for urokinase-type plasminogen activator (u-PA) and its receptor (u-PAR).	Curcumin	55-63	plasminogen activator, urokinase receptor	Mus musculus	256-261
10666014-7	2000	Interestingly, curcumin prevented the general toxicity and mortality induced by PQ and blocked the rise in BALF protein, ACE, AKP, NAG TBARS and neutrophils.	Curcumin	15-23	angiotensin I converting enzyme	Rattus norvegicus	121-124
10580329-4	1999	Binding of curcumin to HSA induces an extrinsic CD band in the visible region.	Curcumin	11-19	albumin	Homo sapiens	23-26
10580329-6	1999	Thus, HSA has two kinds of affinity sites for curcumin, one with high affinity and the other with lower affinity.	Curcumin	46-54	albumin	Homo sapiens	6-9
10580329-8	1999	The equilibrium constant was invariant with temperature in the range of 15 to 45 degrees C, suggesting the role of hydrophobic interactions in the binding of curcumin to HSA.	Curcumin	158-166	albumin	Homo sapiens	170-173
10454518-7	1999	In parallel trials, the lethal actions of ceramide (but not of sphingosine) were markedly diminished by pretreatment with diferuloylmethane or expression of TAM-67, confirming the effectiveness of these interventions in suppression of SAPK/AP1-dependent apoptosis.	Curcumin	122-139	mitogen-activated protein kinase 9	Homo sapiens	235-239
10477620-10	1999	Therefore, curcumin blocks a signal upstream of NF-kappa B-inducing kinase and IKK.	Curcumin	11-19	nuclear factor kappa B subunit 1	Homo sapiens	48-58
10477620-11	1999	We conclude that curcumin potently inhibits cytokine-mediated NF-kappa B activation by blocking a signal leading to IKK activity.	Curcumin	17-25	nuclear factor kappa B subunit 1	Homo sapiens	62-72
10477620-0	1999	Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	34-44
10477620-3	1999	The food derivative curcumin has been shown to inhibit NF-kappa B activity in some cell types.	Curcumin	20-28	nuclear factor kappa B subunit 1	Homo sapiens	55-65
10477620-5	1999	Curcumin inhibited IL-1 beta-mediated ICAM-1 and IL-8 gene expression in IEC-6, HT-29, and Caco-2 cells.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	19-28
10477620-6	1999	Cytokine-induced NF-kappa B DNA binding activity, RelA nuclear translocation, I kappa B alpha degradation, I kappa B serine 32 phosphorylation, and I kappa B kinase (IKK) activity were blocked by curcumin treatment.	Curcumin	196-204	nuclear factor kappa B subunit 1	Homo sapiens	17-27
10477620-6	1999	Cytokine-induced NF-kappa B DNA binding activity, RelA nuclear translocation, I kappa B alpha degradation, I kappa B serine 32 phosphorylation, and I kappa B kinase (IKK) activity were blocked by curcumin treatment.	Curcumin	196-204	NFKB inhibitor alpha	Homo sapiens	78-93
10366429-11	1999	In contrast to uv-irradiated cells, curcumin-treated Jurkat cells considerably increased the level of Bcl-2.	Curcumin	36-44	BCL2 apoptosis regulator	Homo sapiens	102-107
10564565-6	1999	Immunohistochemical localization showed an increase in transforming growth factor-beta1 in curcumin-treated wounds compared to controls.	Curcumin	91-99	transforming growth factor, beta 1	Rattus norvegicus	55-87
10444406-9	1999	Consistent with the promoter and gel-shift studies, curcumin, an inhibitor of AP-1 activation, suppressed the HB-EGF mRNA induction after stretch.	Curcumin	52-60	heparin-binding EGF-like growth factor	Rattus norvegicus	110-116
10444409-0	1999	Systemic administration of the NF-kappaB inhibitor curcumin stimulates muscle regeneration after traumatic injury.	Curcumin	51-59	nuclear factor kappa B subunit 1	Homo sapiens	31-40
10444409-3	1999	We show that the kinetics and extent of muscle regeneration in vivo after trauma are greatly enhanced following systemic administration of curcumin, a pharmacological inhibitor of the transcription factor NF-kappaB.	Curcumin	139-147	nuclear factor kappa B subunit 1	Homo sapiens	205-214
10445426-6	1999	Curcumin treatment caused a reduction in the expression of Ki67, PCNA, and p53 mRNAs in breast cancer cells.	Curcumin	0-8	tumor protein p53	Homo sapiens	75-78
10445426-7	1999	The human mammary epithelial cell line showed a down-regulation of p21 mRNA and an up-regulation of Bax mRNA expression with curcumin treatment.	Curcumin	125-133	BCL2 associated X, apoptosis regulator	Homo sapiens	100-103
12938514-1	1999	To understand the effect of rh-IFN-gamma on the ability of curcumin to kill HL-60 cells in vitro, the myeloid leukemic cell line HL-60 was studied by using cell culture.	Curcumin	59-67	interferon gamma	Homo sapiens	31-40
10084996-11	1999	The AP-1 inhibitor curcumin strongly inhibited LPS-induced VEGF production in HPC cultures.	Curcumin	19-27	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-8
10363643-8	1999	Since curcumin is known as an inhibitor of the c-Jun N-terminal kinase (JNK) signaling pathway acting upstream of the MAP kinase kinase kinase level, one site of action of the COP9 signalosome might be proximal to regulators on that level.	Curcumin	6-14	mitogen-activated protein kinase 8	Homo sapiens	47-70
10363643-8	1999	Since curcumin is known as an inhibitor of the c-Jun N-terminal kinase (JNK) signaling pathway acting upstream of the MAP kinase kinase kinase level, one site of action of the COP9 signalosome might be proximal to regulators on that level.	Curcumin	6-14	mitogen-activated protein kinase 8	Homo sapiens	72-75
9918209-8	1999	I kappa B alpha, a previously identified NF-kappa B-inducible gene, was overexpressed in human pancreatic tumor tissues and cell lines, and RelA activation could be inhibited by curcumin and dominant-negative mutants of I kappa B alpha, raf, and MEKK1.	Curcumin	178-186	NFKB inhibitor alpha	Homo sapiens	0-15
10223193-6	1999	of curcumin (non-specific iNOS inhibitor).	Curcumin	3-11	nitric oxide synthase 2	Rattus norvegicus	26-30
10084996-11	1999	The AP-1 inhibitor curcumin strongly inhibited LPS-induced VEGF production in HPC cultures.	Curcumin	19-27	vascular endothelial growth factor A	Homo sapiens	59-63
10190560-0	1999	Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-34
10190560-1	1999	We investigated whether curcumin, a chemopreventive agent, inhibited chenodeoxycholate (CD)- or phorbol ester (PMA)-mediated induction of cyclooxygenase-2 (COX-2) in several gastrointestinal cell lines (SK-GT-4, SCC450, IEC-18 and HCA-7).	Curcumin	24-32	prostaglandin-endoperoxide synthase 2	Homo sapiens	138-154
10190560-1	1999	We investigated whether curcumin, a chemopreventive agent, inhibited chenodeoxycholate (CD)- or phorbol ester (PMA)-mediated induction of cyclooxygenase-2 (COX-2) in several gastrointestinal cell lines (SK-GT-4, SCC450, IEC-18 and HCA-7).	Curcumin	24-32	prostaglandin-endoperoxide synthase 2	Homo sapiens	156-161
10190560-2	1999	Treatment with curcumin suppressed CD- and PMA-mediated induction of COX-2 protein and synthesis of prostaglandin E2.	Curcumin	15-23	prostaglandin-endoperoxide synthase 2	Homo sapiens	69-74
10190560-3	1999	Curcumin also suppressed the induction of COX-2 mRNA by CD and PMA.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	42-47
10190560-4	1999	Nuclear run-offs revealed increased rates of COX-2 transcription after treatment with CD or PMA and these effects were inhibited by curcumin.	Curcumin	132-140	prostaglandin-endoperoxide synthase 2	Homo sapiens	45-50
10190560-7	1999	In addition to the above effects on gene expression, we found that curcumin directly inhibited the activity of COX-2.	Curcumin	67-75	prostaglandin-endoperoxide synthase 2	Homo sapiens	111-116
9933632-3	1999	This induction of apoptosis was abolished by the caspase inhibitor zVAD-fmk, correlated with the inhibition of nuclear factor-kappa B (NF-kappaB), and was mimicked by a cell permeable inhibitory peptide of NF-kappaB, SN-50; other NF-kappaB inhibitors, curcumin and pyrrolidine dithiocarbamate; and the proteasome inhibitor, MG-132.	Curcumin	252-260	nuclear factor kappa B subunit 1	Homo sapiens	135-144
9933632-3	1999	This induction of apoptosis was abolished by the caspase inhibitor zVAD-fmk, correlated with the inhibition of nuclear factor-kappa B (NF-kappaB), and was mimicked by a cell permeable inhibitory peptide of NF-kappaB, SN-50; other NF-kappaB inhibitors, curcumin and pyrrolidine dithiocarbamate; and the proteasome inhibitor, MG-132.	Curcumin	252-260	nuclear factor kappa B subunit 1	Homo sapiens	206-215
9933632-3	1999	This induction of apoptosis was abolished by the caspase inhibitor zVAD-fmk, correlated with the inhibition of nuclear factor-kappa B (NF-kappaB), and was mimicked by a cell permeable inhibitory peptide of NF-kappaB, SN-50; other NF-kappaB inhibitors, curcumin and pyrrolidine dithiocarbamate; and the proteasome inhibitor, MG-132.	Curcumin	252-260	nuclear factor kappa B subunit 1	Homo sapiens	206-215
12938514-12	1999	It is concluded that IFN-gamma can enhance the antiproliferative ability of curcumin against HL-60 cells.	Curcumin	76-84	interferon gamma	Homo sapiens	21-30
9674701-0	1998	Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin.	Curcumin	69-77	mitogen-activated protein kinase 8	Homo sapiens	18-41
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Curcumin	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	37-41
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Curcumin	0-8	interleukin 1 beta	Homo sapiens	62-70
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	76-85
10051376-6	1999	These results show that curcumin exhibits an inhibitory effect on the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages.	Curcumin	24-32	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
10051376-6	1999	These results show that curcumin exhibits an inhibitory effect on the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages.	Curcumin	24-32	interleukin 1 beta	Homo sapiens	109-117
10051376-6	1999	These results show that curcumin exhibits an inhibitory effect on the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages.	Curcumin	24-32	tumor necrosis factor	Homo sapiens	123-132
9764849-0	1998	Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells.	Curcumin	0-8	tumor protein p53	Homo sapiens	19-22
9764849-3	1998	In our study, consistent with the occurrence of DNA fragmentation, nuclear p53 protein initially increased at 12 h and peaked at 48 h after curcumin treatment.	Curcumin	140-148	tumor protein p53	Homo sapiens	75-78
9674701-6	1998	In transfection assays, curcumin moderately suppressed MEKK1-induced JNK activation; however, it effectively blocked JNK activation caused by co-transfection of TAK1, GCK, or HPK1.	Curcumin	24-32	mitogen-activated protein kinase 8	Homo sapiens	69-72
9674701-6	1998	In transfection assays, curcumin moderately suppressed MEKK1-induced JNK activation; however, it effectively blocked JNK activation caused by co-transfection of TAK1, GCK, or HPK1.	Curcumin	24-32	mitogen-activated protein kinase 8	Homo sapiens	117-120
9674701-9	1998	Our data suggest that curcumin may affect the JNK pathway by interfering with the signaling molecule(s) at the same level or proximally upstream of the MAPKKK level.	Curcumin	22-30	mitogen-activated protein kinase 8	Homo sapiens	46-49
9674701-10	1998	Taken together, the inhibition of the MEKK1-JNK pathway reveals a possible mechanism of suppression of AP-1 and NF-kappaB signaling by curcumin, and may explain the potent anti-inflammatory and anti-carcinogenic effects of this chemical.	Curcumin	135-143	mitogen-activated protein kinase 8	Homo sapiens	44-47
9856863-7	1998	Blocking the interaction of Abeta with p75NTR using NGF or inhibition of NFKB activation by curcumin or NFKB SN50 attenuated or abolished Abeta-induced apoptotic cell death.	Curcumin	92-100	amyloid beta precursor protein	Homo sapiens	138-143
9764849-4	1998	Prior treatment of cells with cycloheximide or actinomycin D abolished the p53 increase and apoptosis induced by curcumin, suggesting that either de novo p53 protein synthesis or some proteins synthesis for stabilization of p53 is required for apoptosis.	Curcumin	113-121	tumor protein p53	Homo sapiens	75-78
9764849-4	1998	Prior treatment of cells with cycloheximide or actinomycin D abolished the p53 increase and apoptosis induced by curcumin, suggesting that either de novo p53 protein synthesis or some proteins synthesis for stabilization of p53 is required for apoptosis.	Curcumin	113-121	tumor protein p53	Homo sapiens	154-157
9764849-4	1998	Prior treatment of cells with cycloheximide or actinomycin D abolished the p53 increase and apoptosis induced by curcumin, suggesting that either de novo p53 protein synthesis or some proteins synthesis for stabilization of p53 is required for apoptosis.	Curcumin	113-121	tumor protein p53	Homo sapiens	154-157
9764849-5	1998	In electrophoretic mobility gel-shift assays, nuclear extracts of cells treated with curcumin displayed distinct patterns of binding between p53 and its consensus binding site.	Curcumin	85-93	tumor protein p53	Homo sapiens	141-144
9764849-6	1998	Supportive of these findings, p53 downstream targets, including p21(CIP1/WAF1) and Gadd45, could be induced to localize on the nucleus by curcumin with similar p53 kinetics.	Curcumin	138-146	tumor protein p53	Homo sapiens	30-33
9764849-6	1998	Supportive of these findings, p53 downstream targets, including p21(CIP1/WAF1) and Gadd45, could be induced to localize on the nucleus by curcumin with similar p53 kinetics.	Curcumin	138-146	cyclin dependent kinase inhibitor 1A	Homo sapiens	64-67
9764849-6	1998	Supportive of these findings, p53 downstream targets, including p21(CIP1/WAF1) and Gadd45, could be induced to localize on the nucleus by curcumin with similar p53 kinetics.	Curcumin	138-146	cyclin dependent kinase inhibitor 1A	Homo sapiens	68-72
9764849-6	1998	Supportive of these findings, p53 downstream targets, including p21(CIP1/WAF1) and Gadd45, could be induced to localize on the nucleus by curcumin with similar p53 kinetics.	Curcumin	138-146	cyclin dependent kinase inhibitor 1A	Homo sapiens	73-77
9764849-6	1998	Supportive of these findings, p53 downstream targets, including p21(CIP1/WAF1) and Gadd45, could be induced to localize on the nucleus by curcumin with similar p53 kinetics.	Curcumin	138-146	tumor protein p53	Homo sapiens	160-163
9764849-10	1998	Finally, treatment of cells with p53 antisense oligonucleotide could effectively prevent curcumin-induced intracellular p53 protein increase and apoptosis, but sense p53 oligonucleotide could not.	Curcumin	89-97	tumor protein p53	Homo sapiens	33-36
9764849-10	1998	Finally, treatment of cells with p53 antisense oligonucleotide could effectively prevent curcumin-induced intracellular p53 protein increase and apoptosis, but sense p53 oligonucleotide could not.	Curcumin	89-97	tumor protein p53	Homo sapiens	120-123
9764849-10	1998	Finally, treatment of cells with p53 antisense oligonucleotide could effectively prevent curcumin-induced intracellular p53 protein increase and apoptosis, but sense p53 oligonucleotide could not.	Curcumin	89-97	tumor protein p53	Homo sapiens	120-123
9764849-11	1998	Thus, our data suggest that the p53-associated signaling pathway is critically involved in curcumin-mediated apoptotic cell death.	Curcumin	91-99	tumor protein p53	Homo sapiens	32-35
9674701-0	1998	Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin.	Curcumin	69-77	mitogen-activated protein kinase 8	Homo sapiens	43-46
9674701-3	1998	In this report, we show that curcumin inhibits JNK activation by various agonists including PMA plus ionomycin, anisomycin, UV-C, gamma radiation, TNF-alpha, and sodium orthovanadate.	Curcumin	29-37	mitogen-activated protein kinase 8	Homo sapiens	47-50
9674701-3	1998	In this report, we show that curcumin inhibits JNK activation by various agonists including PMA plus ionomycin, anisomycin, UV-C, gamma radiation, TNF-alpha, and sodium orthovanadate.	Curcumin	29-37	tumor necrosis factor	Homo sapiens	147-156
9674701-4	1998	Although both JNK and ERK activation by phorbol 12-myristate 13-acetate (PMA) plus ionomycin were suppressed by curcumin, the JNK pathway was more sensitive.	Curcumin	112-120	mitogen-activated protein kinase 8	Homo sapiens	14-17
9674701-4	1998	Although both JNK and ERK activation by phorbol 12-myristate 13-acetate (PMA) plus ionomycin were suppressed by curcumin, the JNK pathway was more sensitive.	Curcumin	112-120	mitogen-activated protein kinase 1	Homo sapiens	22-25
9674701-5	1998	The IC50 (50% inhibition concentration) of curcumin was between 5-10 microM for JNK activation and was 20 microM for ERK activation.	Curcumin	43-51	mitogen-activated protein kinase 8	Homo sapiens	80-83
9674701-5	1998	The IC50 (50% inhibition concentration) of curcumin was between 5-10 microM for JNK activation and was 20 microM for ERK activation.	Curcumin	43-51	mitogen-activated protein kinase 1	Homo sapiens	117-120
9605420-0	1998	Inhibition of nuclear factor kappaB by direct modification in whole cells--mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers.	Curcumin	125-133	nuclear factor kappa B subunit 1	Homo sapiens	14-35
9720770-23	1998	And, the level of bcl-2 mRNA was significantly reduced by 10(-4) M curcumin.	Curcumin	67-75	BCL2, apoptosis regulator	Rattus norvegicus	18-23
9720770-25	1998	The effects of curcumin on the levels of c-myc and bcl-2 mRNA were then confirmed by Northern blotting.	Curcumin	15-23	BCL2, apoptosis regulator	Rattus norvegicus	51-56
9714315-4	1998	Here, we report that in ex vivo cultured BALB/c mouse peritoneal macrophages, 1-20 microM of curcumin reduced the production of iNOS mRNA in a concentration-dependent manner.	Curcumin	93-101	nitric oxide synthase 2, inducible	Mus musculus	128-132
9714315-5	1998	Furthermore, we demonstrated that, in vivo, two oral treatments of 0.5 mL of a 10-microM solution of curcumin (92 ng/g of body weight) reduced iNOS mRNA expression in the livers of lipopolysaccharide(LPS)-injected mice by 50-70%.	Curcumin	101-109	nitric oxide synthase 2, inducible	Mus musculus	143-147
9605420-9	1998	However, only the antioxidants, curcumin and nordihydroguaiaritic acid (NDGA) were found to inhibit IkappaBalpha degradation activated by tumour necrosis factor-alpha.	Curcumin	32-40	NFKB inhibitor alpha	Homo sapiens	100-112
9605420-11	1998	Furthermore, curcumin and nordihydroguaiaritic acid inhibit NFkappaB by interfering with IkappaBalpha degradation and reacting with p50 in the NFkappaB complex.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	60-68
9605420-11	1998	Furthermore, curcumin and nordihydroguaiaritic acid inhibit NFkappaB by interfering with IkappaBalpha degradation and reacting with p50 in the NFkappaB complex.	Curcumin	13-21	NFKB inhibitor alpha	Homo sapiens	89-101
9605420-11	1998	Furthermore, curcumin and nordihydroguaiaritic acid inhibit NFkappaB by interfering with IkappaBalpha degradation and reacting with p50 in the NFkappaB complex.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	132-135
9605420-11	1998	Furthermore, curcumin and nordihydroguaiaritic acid inhibit NFkappaB by interfering with IkappaBalpha degradation and reacting with p50 in the NFkappaB complex.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	143-151
9776860-8	1998	Because transforming growth factor-beta1 is known to enhance wound healing, it may be possible that transforming growth factor-beta1 plays an important role in the enhancement of wound healing by curcumin.	Curcumin	196-204	transforming growth factor, beta 1	Rattus norvegicus	100-132
9586949-0	1998	Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	43-64
9586949-0	1998	Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	66-69
9586949-0	1998	Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation.	Curcumin	10-27	tumor necrosis factor	Homo sapiens	43-64
9586949-0	1998	Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation.	Curcumin	10-27	tumor necrosis factor	Homo sapiens	66-69
9586949-4	1998	Pretreatment of EC for 1 hr with curcumin completely blocked their adhesion to monocytes, as well as the cell surface expression of ICAM-1, VCAM-1, and ELAM-1 in EC.	Curcumin	33-41	vascular cell adhesion molecule 1	Homo sapiens	140-146
9586949-5	1998	Although curcumin inhibited adhesion even when administered 1 hr after TNF treatment, maximum inhibition occurred when added either 1 hr before or at the same time as TNF.	Curcumin	9-17	tumor necrosis factor	Homo sapiens	71-74
9586949-7	1998	A 30-min treatment with TNF activated NF-kappaB; the activation was inhibited in a concentration-dependent manner by pretreatment with curcumin, indicating that NF-kappaB inhibition may play a role in the suppression of expression of adhesion molecules in EC.	Curcumin	135-143	tumor necrosis factor	Homo sapiens	24-27
9586949-7	1998	A 30-min treatment with TNF activated NF-kappaB; the activation was inhibited in a concentration-dependent manner by pretreatment with curcumin, indicating that NF-kappaB inhibition may play a role in the suppression of expression of adhesion molecules in EC.	Curcumin	135-143	nuclear factor kappa B subunit 1	Homo sapiens	38-47
9586949-7	1998	A 30-min treatment with TNF activated NF-kappaB; the activation was inhibited in a concentration-dependent manner by pretreatment with curcumin, indicating that NF-kappaB inhibition may play a role in the suppression of expression of adhesion molecules in EC.	Curcumin	135-143	nuclear factor kappa B subunit 1	Homo sapiens	161-170
9566710-2	1998	We have also shown that a variety of agents which inhibit NF-kappaB, including vitamin E and related antioxidants, curcumin and several non-steroidal anti-inflammatory agents, significantly enhanced the differentiation of HL-60 leukemia cells when combined with low levels of 1,25-dihydroxyvitamin D3 (vitamin D3).	Curcumin	115-123	nuclear factor kappa B subunit 1	Homo sapiens	58-67
9776860-6	1998	Immunohistochemical localization of transforming growth factor-beta1 showed an increase in curcumin-treated wounds as compared with untreated wounds.	Curcumin	91-99	transforming growth factor, beta 1	Rattus norvegicus	36-68
9776860-7	1998	In situ hybridization and polymerase chain reaction analysis also showed an increase in the mRNA transcripts of transforming growth factor-beta1 and fibronectin in curcumin-treated wounds.	Curcumin	164-172	transforming growth factor, beta 1	Rattus norvegicus	112-144
9776860-8	1998	Because transforming growth factor-beta1 is known to enhance wound healing, it may be possible that transforming growth factor-beta1 plays an important role in the enhancement of wound healing by curcumin.	Curcumin	196-204	transforming growth factor, beta 1	Rattus norvegicus	8-40
8890196-7	1996	Furthermore, P-LPS-induced expression of the MCP-1 gene in the cells also was blocked by inhibitors of two transcription factors, i.e., curcumin, an inhibitor of AP-1, and pyrolidine dithiocarbamate, an inhibitor of NF-kappaB.	Curcumin	136-144	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	216-225
9215611-9	1997	Curcumin-induced cell death was neither due to apoptosis nor to any significant change in the expression of apoptosis-related genes, including Bcl-2, p53, cyclin B and transglutaminase.	Curcumin	0-8	tumor protein p53	Homo sapiens	150-153
9049662-6	1997	In vitro incubation of YAC-1 and EL4 tumor cells and normal splenocytes in varying concentrations of curcumin for varying times revealed differences between cell types in curcumin"s effects on cell proliferation and viability.	Curcumin	101-109	ADP-ribosyltransferase 1	Mus musculus	23-28
9049662-6	1997	In vitro incubation of YAC-1 and EL4 tumor cells and normal splenocytes in varying concentrations of curcumin for varying times revealed differences between cell types in curcumin"s effects on cell proliferation and viability.	Curcumin	171-179	ADP-ribosyltransferase 1	Mus musculus	23-28
9049662-9	1997	A lower curcumin concentration (1.25 micrograms/ml) enhanced cell growth in the YAC-1 cells at 24 and 48 hr.	Curcumin	8-16	ADP-ribosyltransferase 1	Mus musculus	80-85
9589348-5	1997	Curcumin, a dietary pigment phytopolyphenol, is also a potent inhibitor of tumor promotion induced by TPA in mouse skin.	Curcumin	0-8	promotion susceptibility QTL 1	Mus musculus	102-105
9589348-7	1997	Treatment with 15 or 20 microM curcumin for 15 min inhibited TPA-induced PKC activity in the particulate fraction by 26-60%.	Curcumin	31-39	promotion susceptibility QTL 1	Mus musculus	61-64
9589348-9	1997	Curcumin (10 microM) suppressed the expression of c-jun in TPA-treated cells.	Curcumin	0-8	promotion susceptibility QTL 1	Mus musculus	59-62
9589348-12	1997	Based on these findings, it is suggested that the suppression of PKC activity and nuclear oncogene expression might contribute to the molecular mechanisms of inhibition of TPA-induced tumor promotion by apigenin and curcumin.	Curcumin	216-224	promotion susceptibility QTL 1	Mus musculus	172-175
9112257-1	1997	Treatment of human promyelocytic leukemia HL-60 cells with 10 muM curcumin for 48 h inhibited cellular proliferation and induced small increases in differentiation (100-200%) as measured by the proportion of cells that reduced nitroblue tetrazolium (NBT) and expressed Mac-1.	Curcumin	66-74	latexin	Homo sapiens	62-65
9112257-2	1997	Synergistic induction of differentiation as measured by the above markers was observed when 1-10 muM curcumin was combined with 10-100 nM all-trans retinoic acid (RA) or with 100 nM 1 alpha, 25-dihydroxyvitamin D3 (vitamin D3).	Curcumin	101-109	latexin	Homo sapiens	97-100
8950193-9	1996	Immunoblot analysis showed that the level of the antiapoptotic protein Bcl-2 was decreased to 30% after 6 h treatment with curcumin, and was subsequently reduced to 20% by a further 6 h treatment.	Curcumin	123-131	BCL2 apoptosis regulator	Homo sapiens	71-76
8950193-10	1996	Furthermore, overexpression of bcl-2 in HL-60 cells resulted in a delay of curcumin-treated cells entering into apoptosis, suggesting that bcl-2 plays a crucial role in the early stage of curcumin-triggered apoptotic cell death.	Curcumin	75-83	BCL2 apoptosis regulator	Homo sapiens	31-36
8950193-10	1996	Furthermore, overexpression of bcl-2 in HL-60 cells resulted in a delay of curcumin-treated cells entering into apoptosis, suggesting that bcl-2 plays a crucial role in the early stage of curcumin-triggered apoptotic cell death.	Curcumin	75-83	BCL2 apoptosis regulator	Homo sapiens	139-144
8950193-10	1996	Furthermore, overexpression of bcl-2 in HL-60 cells resulted in a delay of curcumin-treated cells entering into apoptosis, suggesting that bcl-2 plays a crucial role in the early stage of curcumin-triggered apoptotic cell death.	Curcumin	188-196	BCL2 apoptosis regulator	Homo sapiens	31-36
8950193-10	1996	Furthermore, overexpression of bcl-2 in HL-60 cells resulted in a delay of curcumin-treated cells entering into apoptosis, suggesting that bcl-2 plays a crucial role in the early stage of curcumin-triggered apoptotic cell death.	Curcumin	188-196	BCL2 apoptosis regulator	Homo sapiens	139-144
9437186-6	1997	In the present study, we demonstrate that curcumin (diferulolylmethane), a known anticarcinogenic and anti-inflammatory agent, inhibited phorbol 12-myristate 13-acetate (PMA), LPS, TNF alpha, and thrombin-induced TF activity and TF gene transcription in human endothelial cells.	Curcumin	42-50	tumor necrosis factor	Homo sapiens	181-190
9437186-6	1997	In the present study, we demonstrate that curcumin (diferulolylmethane), a known anticarcinogenic and anti-inflammatory agent, inhibited phorbol 12-myristate 13-acetate (PMA), LPS, TNF alpha, and thrombin-induced TF activity and TF gene transcription in human endothelial cells.	Curcumin	42-50	coagulation factor II, thrombin	Homo sapiens	196-204
9437186-7	1997	The present data show that curcumin prevented the activation of c-Rel/p65, which is essential for TF gene activation in endothelial cells, by impairing the proteolytic degradation inhibitor protein, I kappa B alpha.	Curcumin	27-35	NFKB inhibitor alpha	Homo sapiens	199-214
9437186-8	1997	The data also show that curcumin downregulated AP-1 binding activity.	Curcumin	24-32	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	47-51
9437186-10	1997	Overall, the data suggest that the anticarcinogenic and anti-inflammatory properties of curcumin may be related to its ability to inhibit cellular gene expression regulated by transcription factors NF-kappa B, AP-1, and Egr-1.	Curcumin	88-96	nuclear factor kappa B subunit 1	Homo sapiens	198-208
9437186-10	1997	Overall, the data suggest that the anticarcinogenic and anti-inflammatory properties of curcumin may be related to its ability to inhibit cellular gene expression regulated by transcription factors NF-kappa B, AP-1, and Egr-1.	Curcumin	88-96	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	210-214
9353136-4	1997	Curcumin inhibited Df-induced lymphocyte proliferation and production of IL-2.	Curcumin	0-8	interleukin 2	Homo sapiens	73-77
9353136-5	1997	Exogenous IL-2 reconstituted the proliferative responsiveness of lymphocytes to Df in the presence of curcumin.	Curcumin	102-110	interleukin 2	Homo sapiens	10-14
9353136-6	1997	Furthermore, curcumin inhibited IL-5, GM-CSF, and IL-4 production in a concentration-dependent manner.	Curcumin	13-21	interleukin 4	Homo sapiens	50-54
9439980-0	1997	Curcumin inhibits IL1 alpha and TNF-alpha induction of AP-1 and NF-kB DNA-binding activity in bone marrow stromal cells.	Curcumin	0-8	tumor necrosis factor	Mus musculus	32-41
9439980-5	1997	These data suggest that inhibition of MCP-1/JE transcription by curcumin involves blocking of AP-1 and NF-kB activation by IL1 alpha or TNF-alpha.	Curcumin	64-72	tumor necrosis factor	Mus musculus	136-145
9112258-8	1997	Curcumin caused a marked reduction in NF-kappa B activity in nuclear extracts of HL-60 cells exposed to this agent in the presence or absence of vitamin D3, supporting the possibility that NF-kappa B may be a factor in the regulation of the state of differentiation of leukemia cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	38-48
9112258-8	1997	Curcumin caused a marked reduction in NF-kappa B activity in nuclear extracts of HL-60 cells exposed to this agent in the presence or absence of vitamin D3, supporting the possibility that NF-kappa B may be a factor in the regulation of the state of differentiation of leukemia cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	189-199
8989916-0	1996	Induction of HSP70 gene expression by modulation of Ca(+2) ion and cellular p53 protein by curcumin in colorectal carcinoma cells.	Curcumin	91-99	tumor protein p53	Homo sapiens	76-79
8989916-5	1996	The reduction of p53 gene expression was accompanied by the induction of HSP70 gene expression in the curcumin-treated cells.	Curcumin	102-110	tumor protein p53	Homo sapiens	17-20
8989916-6	1996	These findings suggest that curcumin may induce the expression of the HSP70 gene through the initial depletion of intracellular Ca(+2), followed by the suppression of p53 gene function in the target cells.	Curcumin	28-36	tumor protein p53	Homo sapiens	167-170
8597030-3	1996	Oral administration of spice principles, curcumin from turmeric (30 mg/kg body weight) or eugenol from cloves (100 mg/kg body weight), for 10 days lowered the liver and serum lipid peroxide levels, serum ALAT, ASAT and LDH, enhanced by i.p.	Curcumin	41-49	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	210-214
8663179-9	1996	Because curcumin (20 microM), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta-stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase-dependent signal transduction pathways.	Curcumin	8-16	interleukin 1 beta	Homo sapiens	91-99
8663179-9	1996	Because curcumin (20 microM), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta-stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase-dependent signal transduction pathways.	Curcumin	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
8663179-9	1996	Because curcumin (20 microM), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta-stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase-dependent signal transduction pathways.	Curcumin	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
8663179-9	1996	Because curcumin (20 microM), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta-stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase-dependent signal transduction pathways.	Curcumin	8-16	interleukin 1 beta	Homo sapiens	227-235
8663179-9	1996	Because curcumin (20 microM), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta-stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase-dependent signal transduction pathways.	Curcumin	8-16	C-X-C motif chemokine ligand 8	Homo sapiens	203-207
8663179-9	1996	Because curcumin (20 microM), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta-stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase-dependent signal transduction pathways.	Curcumin	8-16	interleukin 1 beta	Homo sapiens	227-235
9208599-2	1996	We also observed the inhibition of the GJIC by TPA and the antagonistic effect of Curcumin derivatives on TPA.	Curcumin	82-90	plasminogen activator, tissue type	Homo sapiens	106-109
9208599-4	1996	Curcumin derivatives (91022, 91022-S) could counteract the inhibition of TPA-induced GJIC.	Curcumin	0-8	plasminogen activator, tissue type	Homo sapiens	73-76
8599854-4	1996	Curcumin inhibited the reductase activity when measured by the reduction of cytochrome C but not when measured by the reduction of dichlorophenolindophenol, an artificial electron acceptor.	Curcumin	0-8	cytochrome c, somatic	Homo sapiens	76-88
8599854-5	1996	These results, as well as the reversal of curcumin-induced inhibition of P450 reductase activity by higher amounts of cytochrome C, indicated a strong affinity of curcumin towards cytochromes.	Curcumin	42-50	cytochrome c, somatic	Homo sapiens	118-130
8599854-5	1996	These results, as well as the reversal of curcumin-induced inhibition of P450 reductase activity by higher amounts of cytochrome C, indicated a strong affinity of curcumin towards cytochromes.	Curcumin	163-171	cytochrome c, somatic	Homo sapiens	118-130
8534267-1	1996	The effect of curcumin on lysosomal hydrolases in serum and heart was studied by determining the activities of beta-glucuronidase, beta-N-acetylglucosaminidase, cathepsin B, cathepsin D, and acid phosphatase.	Curcumin	14-22	cathepsin D	Rattus norvegicus	174-185
7786295-4	1995	This report shows that, in vitro, curcumin, at 5 microM, inhibited lipopolysaccharide (LPS)-induced production of TNF and IL-1 by a human monocytic macrophage cell line, Mono Mac 6.	Curcumin	34-42	tumor necrosis factor	Homo sapiens	114-117
8769830-10	1996	Transfection of mesangial cells with a c-jun antisense cDNA and treatment with a pharmacological inhibitor of c-Jun/ AP-1, curcumin, revealed that the induction of c-Jun/AP-1 is essential for the expression of MMP-9 by IL-1 beta.	Curcumin	123-131	interleukin 1 beta	Rattus norvegicus	219-228
7559628-6	1995	Besides TNF, curcumin also blocked phorbol ester- and hydrogen peroxide-mediated activation of NF-kappa B.	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	95-105
7559628-9	1995	Our results indicate that curcumin inhibits NF-kappa B activation pathway at a step before I kappa B alpha phosphorylation but after the convergence of various stimuli.	Curcumin	26-34	nuclear factor kappa B subunit 1	Homo sapiens	44-54
7559628-9	1995	Our results indicate that curcumin inhibits NF-kappa B activation pathway at a step before I kappa B alpha phosphorylation but after the convergence of various stimuli.	Curcumin	26-34	NFKB inhibitor alpha	Homo sapiens	91-106
7559628-0	1995	Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected].	Curcumin	63-71	nuclear factor kappa B subunit 1	Homo sapiens	35-45
7559628-0	1995	Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected].	Curcumin	73-90	nuclear factor kappa B subunit 1	Homo sapiens	35-45
7559628-3	1995	In the present report we demonstrate that curcumin (diferuloylmethane), a known anti-inflammatory and anticarcinogenic agent, is a potent inhibitor of NF-kappa B activation.	Curcumin	42-50	nuclear factor kappa B subunit 1	Homo sapiens	151-161
7559628-3	1995	In the present report we demonstrate that curcumin (diferuloylmethane), a known anti-inflammatory and anticarcinogenic agent, is a potent inhibitor of NF-kappa B activation.	Curcumin	52-69	nuclear factor kappa B subunit 1	Homo sapiens	151-161
7559628-4	1995	Treatment of human myeloid ML-1a cells with tumor necrosis factor (TNF) rapidly activated NF-kappa B, which consists of p50 and p65 subunits, and this activation was inhibited by curcumin.	Curcumin	179-187	tumor necrosis factor	Homo sapiens	44-65
7559628-4	1995	Treatment of human myeloid ML-1a cells with tumor necrosis factor (TNF) rapidly activated NF-kappa B, which consists of p50 and p65 subunits, and this activation was inhibited by curcumin.	Curcumin	179-187	tumor necrosis factor	Homo sapiens	67-70
7559628-4	1995	Treatment of human myeloid ML-1a cells with tumor necrosis factor (TNF) rapidly activated NF-kappa B, which consists of p50 and p65 subunits, and this activation was inhibited by curcumin.	Curcumin	179-187	nuclear factor kappa B subunit 1	Homo sapiens	90-100
7559628-4	1995	Treatment of human myeloid ML-1a cells with tumor necrosis factor (TNF) rapidly activated NF-kappa B, which consists of p50 and p65 subunits, and this activation was inhibited by curcumin.	Curcumin	179-187	nuclear factor kappa B subunit 1	Homo sapiens	120-123
7634398-0	1995	Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin.	Curcumin	104-112	epidermal growth factor receptor	Homo sapiens	43-75
7634398-3	1995	There was no effect of curcumin treatment on the amount of surface expression of labeled EGF-R and inhibition of EGF-mediated tyrosine phosphorylation of EGF-R by curcumin was mediated by a reversible mechanism.	Curcumin	163-171	epidermal growth factor receptor	Homo sapiens	154-159
7634398-5	1995	These findings demonstrate that curcumin is a potent inhibitor of a growth stimulatory pathway, the ligand-induced activation of EGF-R, and may potentially be useful in developing anti-proliferative strategies to control tumor cell growth.	Curcumin	32-40	epidermal growth factor receptor	Homo sapiens	129-134
7786295-4	1995	This report shows that, in vitro, curcumin, at 5 microM, inhibited lipopolysaccharide (LPS)-induced production of TNF and IL-1 by a human monocytic macrophage cell line, Mono Mac 6.	Curcumin	34-42	interleukin 1 beta	Homo sapiens	122-126
7786295-5	1995	In addition, it demonstrates that curcumin, at the corresponding concentration, inhibited LPS-induced activation of nuclear factor kappa B and reduced the biological activity of TNF in L929 fibroblast lytic assay.	Curcumin	34-42	tumor necrosis factor	Homo sapiens	178-181
33817806-7	2022	Curcumin also upregulated the expression of genes (e.g., glucagon-like peptide 1) related to DPP-4 activity in the small intestine.	Curcumin	0-8	glucagon	Homo sapiens	57-80
7530002-6	1995	Inhibition of NOS induction was maximal when curcumin was added together with LPS and IFN-gamma and decreased progressively as the interval between curcumin and LPS/IFN-gamma was increased to 18 h.	Curcumin	45-53	interferon gamma	Homo sapiens	165-174
7511111-0	1994	Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase.	Curcumin	0-8	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	57-77
7511111-4	1994	At around 0.1 mM curcumin, PhK, pp60c-src, PkC, PkA, AK, and cPK were inhibited by 98%, 40%, 15%, 10%, 1%, and 0.5%, respectively.	Curcumin	17-25	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	27-30
7511111-5	1994	Lineweaver-Burk plot analysis indicated that curcumin is a non-competitive inhibitor of PhK with a Ki of 0.075 mM.	Curcumin	45-53	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	88-91
7511111-6	1994	Overall, our results indicate that curcumin is a potent and selective inhibitor of phosphorylase kinase, a key regulatory enzyme involved in the metabolism of glycogen.	Curcumin	35-43	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	83-103
33798807-4	2021	In in vivo experiments, curcumin significantly alleviated lung inflammation, histopathological injury and MPO activity, serum concentrations of CCL7, IL-6 and TNF-alpha, and mortality in mice compared to the model group.	Curcumin	24-32	interleukin 6	Mus musculus	150-154
33798807-4	2021	In in vivo experiments, curcumin significantly alleviated lung inflammation, histopathological injury and MPO activity, serum concentrations of CCL7, IL-6 and TNF-alpha, and mortality in mice compared to the model group.	Curcumin	24-32	tumor necrosis factor	Mus musculus	159-168
33798807-7	2021	The results suggested that curcumin remarkably inhibited the expression of NF-kappaB and pyroptosis related proteins and increased the expression of SIRT1.	Curcumin	27-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-84
7812955-3	1995	The present study was designed to investigate the chemopreventive action of dietary curcumin on azoxymethane-induced colon carcinogenesis and also the modulating effect of this agent on the colonic mucosal and tumor phospholipase A2, phospholipase C gamma 1, lipoxygenase, and cyclooxygenase activities in male F344 rats.	Curcumin	84-92	phospholipase C gamma 1	Homo sapiens	234-257
7812955-11	1995	Animals fed the curcumin diet showed decreased activities of colonic mucosal and tumor phospholipase A2 (50%) and phospholipase C gamma 1 (40%) and levels of PGE2 (&gt; 38%).	Curcumin	16-24	phospholipase A2 group IB	Homo sapiens	87-103
7812955-11	1995	Animals fed the curcumin diet showed decreased activities of colonic mucosal and tumor phospholipase A2 (50%) and phospholipase C gamma 1 (40%) and levels of PGE2 (&gt; 38%).	Curcumin	16-24	phospholipase C gamma 1	Homo sapiens	114-137
7883281-0	1995	Prevention of ischaemia-induced biochemical changes by curcumin &amp; quinidine in the cat heart.	Curcumin	55-63	catalase	Homo sapiens	87-90
7803521-1	1994	We explored the mechanism of antigrowth action of Curcumin by investigating its effect on epidermal growth factor (EGF) receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells.	Curcumin	50-58	epidermal growth factor receptor	Homo sapiens	90-128
33761621-9	2021	In all, we demonstrated that curcumin analogue C66 attenuates obesity-induced renal injury by inhibiting chronic inflammation and apoptosis via targeting NF-kappaB and JNK.	Curcumin	29-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	154-163
33809462-8	2021	This review discusses curcumin"s anticancer mechanism through modulation of Rb, p53, MAPK, P13K/Akt, JAK/STAT, Shh, and NF-kappaB pathways, which are commonly involved and dysregulated in preclinical and clinical GBM models.	Curcumin	22-30	tumor protein p53	Homo sapiens	80-83
33809574-2	2021	An important feature of curcumin is the inhibition of nuclear factor kappa of activated B-cells (NF-kappaB).	Curcumin	24-32	nuclear factor kappa B subunit 1	Homo sapiens	97-106
33809574-6	2021	Mesenchymal markers were significantly reduced in cancer specimens after incubation with curcumin, with simultaneous reduction of key transcription factors of EMT, Snail, and Twist.	Curcumin	89-97	snail family transcriptional repressor 1	Homo sapiens	164-169
33809574-6	2021	Mesenchymal markers were significantly reduced in cancer specimens after incubation with curcumin, with simultaneous reduction of key transcription factors of EMT, Snail, and Twist.	Curcumin	89-97	twist family bHLH transcription factor 1	Homo sapiens	175-180
33809574-8	2021	Additionally, curcumin-related inhibition of NF-kappaB nuclear translocation was evident.	Curcumin	14-22	nuclear factor kappa B subunit 1	Homo sapiens	45-54
33809574-9	2021	The combination of PIC with curcumin resulted in further NF-kappaB inhibition, whereas PIC alone contrarily resulted in NF-kappaB activation.	Curcumin	28-36	nuclear factor kappa B subunit 1	Homo sapiens	57-66
33809574-10	2021	Furthermore, curcumin was more effective in inhibiting PIC-dependent NF-kappaB activation and Treg attraction compared to known NF-kappaB inhibitors BAY 11-7082 or caffeic acid phenethyl ester (CAPE).	Curcumin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	69-78
33809462-8	2021	This review discusses curcumin"s anticancer mechanism through modulation of Rb, p53, MAPK, P13K/Akt, JAK/STAT, Shh, and NF-kappaB pathways, which are commonly involved and dysregulated in preclinical and clinical GBM models.	Curcumin	22-30	AKT serine/threonine kinase 1	Homo sapiens	96-99
33233251-3	2020	Food derived proanthocyanidin (PAC) and curcumin (Cur) were loaded onto CSP-NPs and formed as PAC-NPs and Cur-NPs.	Curcumin	40-48	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	72-75
33809242-0	2021	Curcumin Alleviates LPS-Induced Oxidative Stress, Inflammation and Apoptosis in Bovine Mammary Epithelial Cells via the NFE2L2 Signaling Pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Bos taurus	120-126
33000266-12	2020	Additionally, the mRNA and protein levels of apoptosis-associated proteins (Fas, FADD, caspase-8 and caspase-3) and E-cadherin in HCT-116 cells were upregulated following treatment with curcumin in a dose-dependent manner.	Curcumin	186-194	caspase 3	Homo sapiens	101-110
33000266-12	2020	Additionally, the mRNA and protein levels of apoptosis-associated proteins (Fas, FADD, caspase-8 and caspase-3) and E-cadherin in HCT-116 cells were upregulated following treatment with curcumin in a dose-dependent manner.	Curcumin	186-194	cadherin 1	Homo sapiens	116-126
33767985-13	2021	These effects were observed in different in vivo models of breast cancer (e.g., estrogen receptor-positive, triple-negative, chemically induced) showing better outcomes when compared to treatments with free curcumin or negative controls.	Curcumin	207-215	estrogen receptor 1	Homo sapiens	80-97
33000266-13	2020	By contrast, the expression of migration-associated proteins, including MMP-9, NF-kappaB and claudin-3, was downregulated with increasing curcumin concentrations.	Curcumin	138-146	nuclear factor kappa B subunit 1	Homo sapiens	79-88
33233251-8	2020	Therefore, CSP-NPs might be a promising delivery system for hydrophilic molecule proanthocyanidin and hydrophobic molecule curcumin against the oxidative damage, neurodegenerative diseases and cancer, which could facilitate the application of food derived nutrients in functional foods industry.	Curcumin	123-131	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	11-14
33000266-15	2020	Therefore, curcumin induced cell apoptosis and inhibited tumor cell metastasis by regulating the NF-kappaB signaling pathway, and its therapeutic effect may be comparable to that of 5-FU.	Curcumin	11-19	nuclear factor kappa B subunit 1	Homo sapiens	97-106
22771723-7	2012	The anti-invasive activity of curcumin was elevated when heme oxygenase-1 was knocked down by siRNA or inhibited by pharmacological inhibitor.	Curcumin	30-38	heme oxygenase 1	Mus musculus	57-73
32796756-4	2020	Beeswax organogels with and without curcumin, with a beta" orthorhombic subcell structure, showed a predominant elastic behavior and a melting event wider and shifted to lower temperatures than pure beeswax, suggesting a plasticizer effect of the oil in the wax crystals.	Curcumin	36-44	amyloid beta precursor protein	Homo sapiens	51-57
29058812-0	2018	The effects of Curcumin on HCT-116 cells proliferation and apoptosis via the miR-491/PEG10 pathway.	Curcumin	15-23	paternally expressed 10	Homo sapiens	85-90
29058812-5	2018	Meanwhile, the impaction of Curcumin on miR-491, PEG10, and Wnt/beta-catenin signaling pathway were analyzed in HCT-116 cells.	Curcumin	28-36	paternally expressed 10	Homo sapiens	49-54
29058812-10	2018	In addition, Curcumin could up-regulate miR-491, inhibit PEG10, and Wnt/beta-catenin signaling pathway.	Curcumin	13-21	paternally expressed 10	Homo sapiens	57-62
29058812-11	2018	Consequently, Curcumin reduced HCT-116 cells proliferation and promoted cells apoptosis via the miR-491/PEG10 pathway.	Curcumin	14-22	paternally expressed 10	Homo sapiens	104-109
29058812-12	2018	In conclusion, PEG10 was a target gene of miR-491, miR-491/PEG10 strengthen the sensitivity of Curcumin in HCT-116 cells proliferation and apoptosis, which might act as an ideal diagnostic biomarker treatment methods.	Curcumin	95-103	paternally expressed 10	Homo sapiens	15-20
29058812-12	2018	In conclusion, PEG10 was a target gene of miR-491, miR-491/PEG10 strengthen the sensitivity of Curcumin in HCT-116 cells proliferation and apoptosis, which might act as an ideal diagnostic biomarker treatment methods.	Curcumin	95-103	paternally expressed 10	Homo sapiens	59-64
30227240-10	2018	Curcumin LPMPs remarkably attenuated lung injuries, decreased hydroxyproline contents, reduced the synthesis of collagen I, and inhibited the expressions of TNF-alpha, TGF-beta1, NF-kappaB p65 and MMP9.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	157-166
30227240-10	2018	Curcumin LPMPs remarkably attenuated lung injuries, decreased hydroxyproline contents, reduced the synthesis of collagen I, and inhibited the expressions of TNF-alpha, TGF-beta1, NF-kappaB p65 and MMP9.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	168-177
30227240-10	2018	Curcumin LPMPs remarkably attenuated lung injuries, decreased hydroxyproline contents, reduced the synthesis of collagen I, and inhibited the expressions of TNF-alpha, TGF-beta1, NF-kappaB p65 and MMP9.	Curcumin	0-8	synaptotagmin 1	Rattus norvegicus	189-192
22771723-0	2012	Curcumin-induced heme oxygenase-1 expression plays a negative role for its anti-cancer effect in bladder cancers.	Curcumin	0-8	heme oxygenase 1	Mus musculus	17-33
22771723-2	2012	Curcumin, one of these anti-cancer phytochemicals, has been reported to induce the cytoprotective enzyme heme oxygenase-1 expression.	Curcumin	0-8	heme oxygenase 1	Mus musculus	105-121
22771723-6	2012	Ten micrometer curcumin increased the intracellular reactive oxygen species concentration and heme oxygenase-1 protein and mRNA expression in bladder cancer cells.	Curcumin	15-23	heme oxygenase 1	Mus musculus	94-110
22771723-8	2012	In vivo, curcumin induced heme oxygenase-1 protein expression in the lung tissue of murine lung metastasis tumor model and in the bladder tissue of murine orthotopic bladder tumor model.	Curcumin	9-17	heme oxygenase 1	Mus musculus	26-42
22771723-9	2012	Taken together, our data suggest that curcumin-induced heme oxygenase-1 attenuates the anti-invasive effect of curcumin in cancer therapy, and co-treatment by heme oxygenase-1 inhibitor enhances the anti-invasive activity of curcumin.	Curcumin	38-46	heme oxygenase 1	Mus musculus	55-71
22771723-9	2012	Taken together, our data suggest that curcumin-induced heme oxygenase-1 attenuates the anti-invasive effect of curcumin in cancer therapy, and co-treatment by heme oxygenase-1 inhibitor enhances the anti-invasive activity of curcumin.	Curcumin	111-119	heme oxygenase 1	Mus musculus	55-71
22771723-9	2012	Taken together, our data suggest that curcumin-induced heme oxygenase-1 attenuates the anti-invasive effect of curcumin in cancer therapy, and co-treatment by heme oxygenase-1 inhibitor enhances the anti-invasive activity of curcumin.	Curcumin	111-119	heme oxygenase 1	Mus musculus	55-71
34980359-8	2022	These results indicate show that high DS of AHS and ADS could be used as a potential carrier for curcumin delivery.	Curcumin	97-105	alpha 2-HS glycoprotein	Homo sapiens	44-47
18321735-3	2008	METHODS: Interleukin-1beta (IL-1beta)-stimulated C-28/I2 cells were cultured in the presence of GlcN, curcumin, and diacerein prior to the evaluation of parameters such as viability, morphology and proliferation.	Curcumin	102-110	interleukin 1 beta	Homo sapiens	9-26
34837640-0	2022	Curcumin Ameliorates Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity Via Suppressing Oxidative Stress and Modulating iNOS, NF-kappaB, and TNF-alpha in Rats.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	144-153
34837640-0	2022	Curcumin Ameliorates Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity Via Suppressing Oxidative Stress and Modulating iNOS, NF-kappaB, and TNF-alpha in Rats.	Curcumin	0-8	nitric oxide synthase 2	Rattus norvegicus	123-127
34894517-5	2022	ELISA results showed curcumin could significantly reduce the secretion of IL-17A, IL-1beta, IL -6 and TGF-beta1.	Curcumin	21-29	interleukin 1 alpha	Rattus norvegicus	82-90
34894517-5	2022	ELISA results showed curcumin could significantly reduce the secretion of IL-17A, IL-1beta, IL -6 and TGF-beta1.	Curcumin	21-29	interleukin 6	Rattus norvegicus	92-97
34894517-5	2022	ELISA results showed curcumin could significantly reduce the secretion of IL-17A, IL-1beta, IL -6 and TGF-beta1.	Curcumin	21-29	transforming growth factor, beta 1	Rattus norvegicus	102-111
34894517-7	2022	Furthermore, The genes encoding Col1a1, Fasn, Pck1, Bmp10, IL33 and Figf were pivotal and possible key genes for the therapeutic mechanisms of curcumin.Curcumin can reduce the degree of left atrial fibrosis of AF and the secretion of inflammatory factors.	Curcumin	143-151	collagen type I alpha 1 chain	Rattus norvegicus	32-38
34894517-7	2022	Furthermore, The genes encoding Col1a1, Fasn, Pck1, Bmp10, IL33 and Figf were pivotal and possible key genes for the therapeutic mechanisms of curcumin.Curcumin can reduce the degree of left atrial fibrosis of AF and the secretion of inflammatory factors.	Curcumin	152-160	collagen type I alpha 1 chain	Rattus norvegicus	32-38
34894517-9	2022	Besides, COL1A1, FASN, PCK1, BMP10, IL33 and FIGF were the pivotal genes associated with mechanisms of action of curcumin on AF.	Curcumin	113-121	collagen type I alpha 1 chain	Rattus norvegicus	9-15
34894518-10	2022	CM supplementation (25 mg/kg) significantly decreased serum p53, TNF-alpha, CRP and IL-6 compared with MF.	Curcumin	0-2	tumor necrosis factor	Mus musculus	65-74
34953057-10	2022	Inhibition of the NF-kappaB signal pathway by curcumin reversed the effect of upregulation of miR-192 on proliferation, apoptosis and cisplatin-resistance in lung cancer cells.	Curcumin	46-54	nuclear factor kappa B subunit 1	Homo sapiens	18-27
34614532-0	2022	Evaluation of Protective Effects of Curcumin and Nanocurcumin on Aluminium Phosphide-Induced Subacute Lung Injury in Rats: Modulation of Oxidative Stress through SIRT1/FOXO3 Signalling Pathway.	Curcumin	36-44	sirtuin 1	Rattus norvegicus	162-167
34614532-9	2022	RESULTS: Curcumin and nanocurcumin produced a remarkable improvement in AlP-induced lung damage through reduction of MDA, induction of antioxidant capacity (TAC, TTG) and antioxidant enzymes (CAT, GPx), modulation of histopathological changes, and up-regulation of genes expression of SIRT1, FOXO3, FOXO1 in lung tissue.	Curcumin	9-17	catalase	Rattus norvegicus	192-195
34614532-9	2022	RESULTS: Curcumin and nanocurcumin produced a remarkable improvement in AlP-induced lung damage through reduction of MDA, induction of antioxidant capacity (TAC, TTG) and antioxidant enzymes (CAT, GPx), modulation of histopathological changes, and up-regulation of genes expression of SIRT1, FOXO3, FOXO1 in lung tissue.	Curcumin	9-17	sirtuin 1	Rattus norvegicus	285-290
34865233-0	2022	Curcumin plays a local anti-inflammatory and antioxidant role via the HMGB1/TLR4/NF-KappaB pathway in rat masseter muscle under psychological stress.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	76-80
34865233-12	2022	Mechanistically, increased levels of phosphorylated NF-kappaB, toll-like receptor 4, and HMGB1 were observed, which were also ameliorated by curcumin treatment.	Curcumin	141-149	toll-like receptor 4	Rattus norvegicus	63-83
34865233-14	2022	Psychological stress activates HMGB1 expression and increases the expression of downstream TLR4 and p-NF-kappaB, which could be reduced by curcumin.	Curcumin	139-147	toll-like receptor 4	Rattus norvegicus	91-95
34865233-15	2022	Thus, curcumin might exert anti-inflammatory and antioxidant effects in masseter muscles via the HMGB1/TLR4/NF-kappaB pathway.	Curcumin	6-14	toll-like receptor 4	Rattus norvegicus	103-107
34634291-8	2022	Additionally, curcumin was found to exert selective cytotoxicity on thyroid cancer cells but not normal epithelial cells and acted as an autophagy inducer through activation of MAPK while inhibition of mTOR pathways.	Curcumin	14-22	mechanistic target of rapamycin kinase	Homo sapiens	202-206
34392117-0	2022	Nanocomplexes of curcumin and glycated bovine serum albumin: The formation mechanism and effect of glycation on their physicochemical properties.	Curcumin	17-25	albumin	Homo sapiens	46-59
34392117-1	2022	Bovine serum albumin (BSA) and BSA-glucose conjugates (GBSAI and GBSAII) with different extent of glycation were complexed with curcumin (CUR).	Curcumin	128-136	albumin	Homo sapiens	7-20
34953057-10	2022	Inhibition of the NF-kappaB signal pathway by curcumin reversed the effect of upregulation of miR-192 on proliferation, apoptosis and cisplatin-resistance in lung cancer cells.	Curcumin	46-54	microRNA 192	Homo sapiens	94-101
34407450-7	2022	Interestingly, while not contributing to changes in Smad-mediated TGFbeta signaling, curcumin caused early activation of MAPK signaling in all cell lines, including JNK, an effect possibly involving interactions with TGFbetaR2 within lipid rafts.	Curcumin	85-93	mitogen-activated protein kinase 8	Homo sapiens	165-168
34902518-0	2022	Curcumin enhances the proliferation and myelinization of Schwann cells through Runx2 to repair sciatic nerve injury.	Curcumin	0-8	RUNX family transcription factor 2	Rattus norvegicus	79-84
34902518-1	2022	BACKGROUND: RUNX Family Transcription Factor 2 (Runx2) promotes neurite outgrowth after sciatic nerve injury, and Curcumin can promote the expression of Runx2.	Curcumin	114-122	RUNX family transcription factor 2	Rattus norvegicus	12-46
34902518-1	2022	BACKGROUND: RUNX Family Transcription Factor 2 (Runx2) promotes neurite outgrowth after sciatic nerve injury, and Curcumin can promote the expression of Runx2.	Curcumin	114-122	RUNX family transcription factor 2	Rattus norvegicus	153-158
34902518-2	2022	It is worthwhile to explore whether curcumin"s repair effect on sciatic nerve injury is related to Runx2.	Curcumin	36-44	RUNX family transcription factor 2	Rattus norvegicus	99-104
34902518-6	2022	Curcumin treatment increased the proliferation of SCs and the expression of Runx2.	Curcumin	0-8	RUNX family transcription factor 2	Rattus norvegicus	76-81
34902518-7	2022	Cell experiments further confirmed that curcumin promoted Schwann cell proliferation and myelination through Runx2.	Curcumin	40-48	RUNX family transcription factor 2	Rattus norvegicus	109-114
34902518-8	2022	CONCLUSION: Curcumin promotes SCs proliferation and myelination through Runx2 and improves sciatic nerve repair.	Curcumin	12-20	RUNX family transcription factor 2	Rattus norvegicus	72-77
34719837-0	2022	Inhibition of boldenone-induced aggression in rats by curcumin: Targeting TLR4/MyD88/TRAF-6/NF-kappaB pathway.	Curcumin	54-62	toll-like receptor 4	Rattus norvegicus	74-78
34719837-10	2022	Interestingly, curcumin mitigated boldenone-induced neurobehavioral disturbances in rats, normalized the oxidant/antioxidant balance, and suppressed TLR4/MyD88/TRAF-6/NF-kappaB pathway and its downstream proinflammatory signaling molecules TNF-alpha and IL-1beta.	Curcumin	15-23	toll-like receptor 4	Rattus norvegicus	149-153
34719837-10	2022	Interestingly, curcumin mitigated boldenone-induced neurobehavioral disturbances in rats, normalized the oxidant/antioxidant balance, and suppressed TLR4/MyD88/TRAF-6/NF-kappaB pathway and its downstream proinflammatory signaling molecules TNF-alpha and IL-1beta.	Curcumin	15-23	tumor necrosis factor	Rattus norvegicus	240-249
34719837-10	2022	Interestingly, curcumin mitigated boldenone-induced neurobehavioral disturbances in rats, normalized the oxidant/antioxidant balance, and suppressed TLR4/MyD88/TRAF-6/NF-kappaB pathway and its downstream proinflammatory signaling molecules TNF-alpha and IL-1beta.	Curcumin	15-23	interleukin 1 alpha	Rattus norvegicus	254-262
34896432-6	2022	Curcumin was also able to alleviated the oxidative stress triggered by ATO, which was manifested by the increase of T-AOC and SOD, and MDA decrease.	Curcumin	0-8	superoxide dismutase 1	Homo sapiens	126-129
34586711-0	2022	Effect of curcumin on C-reactive protein as a biomarker of systemic inflammation: An updated meta-analysis of randomized controlled trials.	Curcumin	10-18	C-reactive protein	Homo sapiens	22-40
34586711-1	2022	It has been suggested that curcumin is a potential agent for lowering the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP), as markers of inflammation.	Curcumin	27-35	C-reactive protein	Homo sapiens	84-102
34586711-1	2022	It has been suggested that curcumin is a potential agent for lowering the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP), as markers of inflammation.	Curcumin	27-35	C-reactive protein	Homo sapiens	104-107
34586711-1	2022	It has been suggested that curcumin is a potential agent for lowering the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP), as markers of inflammation.	Curcumin	27-35	C-reactive protein	Homo sapiens	130-133
34586711-1	2022	It has been suggested that curcumin is a potential agent for lowering the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP), as markers of inflammation.	Curcumin	27-35	C-reactive protein	Homo sapiens	138-141
34586711-2	2022	In the current meta-analysis, we attempted to clarify the efficacy of curcumin supplementation in lowering the concentrations of CRP and hs-CRP in patients with autoinflammatory conditions.	Curcumin	70-78	C-reactive protein	Homo sapiens	129-132
34586711-2	2022	In the current meta-analysis, we attempted to clarify the efficacy of curcumin supplementation in lowering the concentrations of CRP and hs-CRP in patients with autoinflammatory conditions.	Curcumin	70-78	C-reactive protein	Homo sapiens	140-143
34586711-3	2022	Nine studies were found evaluating the effect of curcumin on CRP levels, while 23 studies were identified for hs-CRP.	Curcumin	49-57	C-reactive protein	Homo sapiens	61-64
34586711-5	2022	There was a significant effect of curcumin at dose <=1,000 mg/day on the CRP concentration.	Curcumin	34-42	C-reactive protein	Homo sapiens	73-76
34586711-8	2022	Curcumin consumption resulted in a reduction of hs-CRP in a non-linear fashion with stronger effects with less than 2000 mg curcumin per day.	Curcumin	0-8	C-reactive protein	Homo sapiens	51-54
34586711-8	2022	Curcumin consumption resulted in a reduction of hs-CRP in a non-linear fashion with stronger effects with less than 2000 mg curcumin per day.	Curcumin	124-132	C-reactive protein	Homo sapiens	51-54
34586711-9	2022	Curcumin seems to be beneficial in decreasing the hs-CRP and CRP levels in proinflammatory settings.	Curcumin	0-8	C-reactive protein	Homo sapiens	53-56
34586711-9	2022	Curcumin seems to be beneficial in decreasing the hs-CRP and CRP levels in proinflammatory settings.	Curcumin	0-8	C-reactive protein	Homo sapiens	61-64
34896432-8	2022	Our further investigation found that ATO disrupted normal mitochondrial fission/fusion (Drp1, OPA1, Mfn1/2) and restrained mitochondrial biogenesis (PGC-1alpha, Nrf1/2, TFAM), while curcumin could promote mitochondrial fusion and activated PGC-1alpha pathway.	Curcumin	182-190	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	94-98
34896432-8	2022	Our further investigation found that ATO disrupted normal mitochondrial fission/fusion (Drp1, OPA1, Mfn1/2) and restrained mitochondrial biogenesis (PGC-1alpha, Nrf1/2, TFAM), while curcumin could promote mitochondrial fusion and activated PGC-1alpha pathway.	Curcumin	182-190	PPARG coactivator 1 alpha	Homo sapiens	240-250
34896432-9	2022	Furthermore, curcumin was found that it could not only reduce the mRNA and protein levels of mitophagy (PINK1, Parkin, LC3, p62) and pro-apoptotic genes (p53, Bax, Caspase-3, Cytc), but also increased the levels of anti-apoptotic genes (Bcl-2).	Curcumin	13-21	tumor protein p53	Homo sapiens	154-157
34896432-9	2022	Furthermore, curcumin was found that it could not only reduce the mRNA and protein levels of mitophagy (PINK1, Parkin, LC3, p62) and pro-apoptotic genes (p53, Bax, Caspase-3, Cytc), but also increased the levels of anti-apoptotic genes (Bcl-2).	Curcumin	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	159-162
34896432-9	2022	Furthermore, curcumin was found that it could not only reduce the mRNA and protein levels of mitophagy (PINK1, Parkin, LC3, p62) and pro-apoptotic genes (p53, Bax, Caspase-3, Cytc), but also increased the levels of anti-apoptotic genes (Bcl-2).	Curcumin	13-21	caspase 3	Homo sapiens	164-173
34896432-9	2022	Furthermore, curcumin was found that it could not only reduce the mRNA and protein levels of mitophagy (PINK1, Parkin, LC3, p62) and pro-apoptotic genes (p53, Bax, Caspase-3, Cytc), but also increased the levels of anti-apoptotic genes (Bcl-2).	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	237-242
34958454-17	2022	Using a microRNA (miRNA) microArray assay, miR-137, a tumor suppressor in colon cancer, was significantly induced by curcumin treatments in CRC cells.	Curcumin	117-125	microRNA 137	Homo sapiens	43-50
34958454-20	2022	Finally, curcumin treatment overcame cisplatin resistance through miR-137-mediated glutamine inhibition.	Curcumin	9-17	microRNA 137	Homo sapiens	66-73
34958454-21	2022	CONCLUSION: Collectively, these results indicate that curcumin could be clinically applied as an anti-chemoresistance approach against CRC by modulating miR-137-inhibited glutamine metabolism.	Curcumin	54-62	microRNA 137	Homo sapiens	153-160
34911931-9	2021	Curcumin, a powerful antioxidant natural compound, prevented the alterations of apoptotic cascade, MAPKs, and SUMO-1 pathways and the degradation system, preserving the RGC survival and the retinal layer thickness.	Curcumin	0-8	small ubiquitin-like modifier 1	Mus musculus	110-116
34931590-5	2022	Curcumin effectively upregulated the change rate of mouse weight, colonic length, down-regulated colonic weight, index of colonic weight, colonic damage score and the levels of pro-inflammatory cytokines IL-6, IL-12, IL-23 and TGF-(Formula: see text)1 in colonic tissues of colitis mice.	Curcumin	0-8	interleukin 6	Mus musculus	204-208
34931590-7	2022	In addition, curcumin inhibited the expression of Tfh-related transcription factors BCL-6, p-STAT3, Foxp1, Roquin-1, Roquin-2 and SAP, and significantly upregulated the protein levels of Blimp-1 and STAT3 in colon tissue.	Curcumin	13-21	signal transducer and activator of transcription 3	Mus musculus	93-98
34931590-7	2022	In addition, curcumin inhibited the expression of Tfh-related transcription factors BCL-6, p-STAT3, Foxp1, Roquin-1, Roquin-2 and SAP, and significantly upregulated the protein levels of Blimp-1 and STAT3 in colon tissue.	Curcumin	13-21	RING CCCH (C3H) domains 1	Mus musculus	107-115
34931590-7	2022	In addition, curcumin inhibited the expression of Tfh-related transcription factors BCL-6, p-STAT3, Foxp1, Roquin-1, Roquin-2 and SAP, and significantly upregulated the protein levels of Blimp-1 and STAT3 in colon tissue.	Curcumin	13-21	SH2 domain containing 1A	Mus musculus	130-133
34931590-7	2022	In addition, curcumin inhibited the expression of Tfh-related transcription factors BCL-6, p-STAT3, Foxp1, Roquin-1, Roquin-2 and SAP, and significantly upregulated the protein levels of Blimp-1 and STAT3 in colon tissue.	Curcumin	13-21	signal transducer and activator of transcription 3	Mus musculus	199-204
34939316-12	2022	Concluding, our study shows that curcumin significantly downregulated gene expression related to the remodelling process, which is dependent on NF-kappaB and, partially, on c-Myc and STAT3.	Curcumin	33-41	nuclear factor kappa B subunit 1	Homo sapiens	144-153
34939316-12	2022	Concluding, our study shows that curcumin significantly downregulated gene expression related to the remodelling process, which is dependent on NF-kappaB and, partially, on c-Myc and STAT3.	Curcumin	33-41	signal transducer and activator of transcription 3	Homo sapiens	183-188
34950248-0	2021	Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1alpha/FNDC5/BDNF Pathway.	Curcumin	0-8	PPARG coactivator 1 alpha	Rattus norvegicus	97-107
34959418-0	2021	Drug Delivery Strategies for Curcumin and Other Natural Nrf2 Modulators of Oxidative Stress-Related Diseases.	Curcumin	29-37	NFE2 like bZIP transcription factor 2	Homo sapiens	56-60
34959418-3	2021	The implication of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in the cellular redox status has spurred new interest in the use of its natural modulators (e.g., curcumin, resveratrol).	Curcumin	180-188	NFE2 like bZIP transcription factor 2	Homo sapiens	23-66
34959418-3	2021	The implication of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in the cellular redox status has spurred new interest in the use of its natural modulators (e.g., curcumin, resveratrol).	Curcumin	180-188	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
34666601-0	2021	Curcumin protection against ultraviolet-induced photo-damage in Hacat cells by regulating nuclear factor erythroid 2-related factor 2.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	90-133
34402718-0	2021	Curcumin induces apoptosis and autophagy inhuman renal cell carcinoma cells via Akt/mTOR suppression.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	80-83
34402718-0	2021	Curcumin induces apoptosis and autophagy inhuman renal cell carcinoma cells via Akt/mTOR suppression.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	84-88
34402718-10	2021	Likewise, AKT/mTOR proteins expression were significantly reduced while the autophagy-related proteins were significantly elevated following curcumin treatment.	Curcumin	141-149	AKT serine/threonine kinase 1	Homo sapiens	10-13
34402718-10	2021	Likewise, AKT/mTOR proteins expression were significantly reduced while the autophagy-related proteins were significantly elevated following curcumin treatment.	Curcumin	141-149	mechanistic target of rapamycin kinase	Homo sapiens	14-18
34402718-12	2021	In conclusion, the investigation demonstrated that curcumin suppressed ACHN cell viability, induced apoptosis and autophagy, through the suppression of AKT/mTOR pathway.	Curcumin	51-59	AKT serine/threonine kinase 1	Homo sapiens	152-155
34402718-12	2021	In conclusion, the investigation demonstrated that curcumin suppressed ACHN cell viability, induced apoptosis and autophagy, through the suppression of AKT/mTOR pathway.	Curcumin	51-59	mechanistic target of rapamycin kinase	Homo sapiens	156-160
34402718-13	2021	Use of curcumin to target AKT/mTOR pathway could be an effective treatment alternative for renal cell carcinoma.	Curcumin	7-15	AKT serine/threonine kinase 1	Homo sapiens	26-29
34402718-13	2021	Use of curcumin to target AKT/mTOR pathway could be an effective treatment alternative for renal cell carcinoma.	Curcumin	7-15	mechanistic target of rapamycin kinase	Homo sapiens	30-34
34955862-0	2021	Curcumin is a Potential Adjuvant to Alleviates Diabetic Retinal Injury via Reducing Oxidative Stress and Maintaining Nrf2 Pathway Homeostasis.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	117-121
34955862-9	2021	Treatment of curcumin alleviated the compensatory activation of the Nrf2 pathway induced by oxidative stress, by virtue of its antioxidant ability to transfer hydrogen atoms to free radicals.	Curcumin	13-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	68-72
34955862-10	2021	When curcumin combined with insulin, the effect of maintaining Nrf2 pathway homeostasis in diabetic rats was better than that of insulin alone.	Curcumin	5-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-67
34955862-11	2021	Transcriptomic analyses revealed that curcumin either alone, or combined with insulin, inhibited the AGE-RAGE signaling pathway and the extracellular matrix (ECM)-receptor interaction in the diabetic retina.	Curcumin	38-46	advanced glycosylation end product-specific receptor	Rattus norvegicus	105-109
34956875-10	2021	Results: We demonstrated that herbal (curcumin and perillyl alcohol) blockade of NF-kappaB specifically suppresses the expression of inducible CD59 but not CD20, thus sensitizing resistant cells to rituximab-mediated CDC.	Curcumin	38-46	nuclear factor kappa B subunit 1	Homo sapiens	81-90
34956875-10	2021	Results: We demonstrated that herbal (curcumin and perillyl alcohol) blockade of NF-kappaB specifically suppresses the expression of inducible CD59 but not CD20, thus sensitizing resistant cells to rituximab-mediated CDC.	Curcumin	38-46	CD59 molecule (CD59 blood group)	Homo sapiens	143-147
34666601-1	2021	Curcumin suppressed ultraviolet (UV) induced skin carcinogenesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	83-126
34666601-1	2021	Curcumin suppressed ultraviolet (UV) induced skin carcinogenesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	128-132
34666601-4	2021	Nrf2 was knocked down in Hacat cells to verify the Nrf2 role in the protective effect of curcumin.	Curcumin	89-97	NFE2 like bZIP transcription factor 2	Homo sapiens	51-55
34666601-7	2021	Meanwhile, we found that the application of curcumin effectively induced Nrf2 nuclear accumulation in Hacat cells.	Curcumin	44-52	NFE2 like bZIP transcription factor 2	Homo sapiens	73-77
34666601-8	2021	While in the Nrf2 knockdown cells, the protective effects of curcumin against UVA (or UVB) were attenuated.	Curcumin	61-69	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
34666601-9	2021	Conclusively, curcumin protects Hacat cells against UV exposure-induced photo-damage by regulating Nrf2 expression.	Curcumin	14-22	NFE2 like bZIP transcription factor 2	Homo sapiens	99-103
34530259-0	2021	Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via Nrf2-associated ROS inhibition.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
34626726-6	2021	Owing to the antioxidant and anti-inflammatory effects of curcumin, DCC-treated HSCs produced much lower levels of reactive oxygen species and inducible nitric oxide synthase than the bare anti-DR5 antibody-treated HSCs.	Curcumin	58-66	nitric oxide synthase 2, inducible	Mus musculus	143-174
34791915-7	2021	CONCLUSION:  The present study concludes that the combination of curcumin and resveratrol significantly sensitized the EOC cells to cisplatin treatment, thereby inhibiting chemoresistance in ovarian cancer cells by significant inhibition of the PI3K/AKT/mTOR pathway.	Curcumin	65-73	AKT serine/threonine kinase 1	Homo sapiens	250-253
34791915-7	2021	CONCLUSION:  The present study concludes that the combination of curcumin and resveratrol significantly sensitized the EOC cells to cisplatin treatment, thereby inhibiting chemoresistance in ovarian cancer cells by significant inhibition of the PI3K/AKT/mTOR pathway.	Curcumin	65-73	mechanistic target of rapamycin kinase	Homo sapiens	254-258
34694468-0	2021	Correction to: Co(II) complexes of curcumin and a ferrocene-based curcuminoid: a study on photo-induced antitumor activity.	Curcumin	35-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	15-21
34601070-7	2021	RESULTS: The lowest effective CYP3A4 inhibitory concentrations were observed for curcumin (75microM and 100 microM), quercetin (75 and 100 microM) and glycyrrhizic acid (50 microM) while the most effective p-glycoprotein (P-gp) inhibition concentrations were curcumin (10, 15, 25, 50, 75 and 100 microM), sinomenine (50, 75, and 100 microM), quercetin (75 and 100 microM) and naringin (50 microM).	Curcumin	81-89	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	30-36
34601070-7	2021	RESULTS: The lowest effective CYP3A4 inhibitory concentrations were observed for curcumin (75microM and 100 microM), quercetin (75 and 100 microM) and glycyrrhizic acid (50 microM) while the most effective p-glycoprotein (P-gp) inhibition concentrations were curcumin (10, 15, 25, 50, 75 and 100 microM), sinomenine (50, 75, and 100 microM), quercetin (75 and 100 microM) and naringin (50 microM).	Curcumin	259-267	ATP binding cassette subfamily B member 1	Homo sapiens	222-226
34601070-9	2021	CONCLUSION: Incorporation of the drug absorption enhancers (e.g., curcumin and quercetin), at specific concentrations, in dosage forms could improve the bioavailability of the BCS Class III and IV drugs that are substrates of CYP3A4 and p-glycoprotein.	Curcumin	66-74	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	226-232
34601070-9	2021	CONCLUSION: Incorporation of the drug absorption enhancers (e.g., curcumin and quercetin), at specific concentrations, in dosage forms could improve the bioavailability of the BCS Class III and IV drugs that are substrates of CYP3A4 and p-glycoprotein.	Curcumin	66-74	ATP binding cassette subfamily B member 1	Homo sapiens	237-251
34751624-5	2021	Curcumin significantly downregulated the TGF-beta1, P-Smad2/3, cleaved caspase-3, cleaved caspase-8 and Dragon levels.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	41-50
34643929-10	2021	Finally, curcumin inhibited BLM-induced increases in AM production of TGF-beta1.	Curcumin	9-17	transforming growth factor, beta 1	Rattus norvegicus	70-79
34643929-11	2021	CONCLUSIONS: Our data demonstrate for the first time that curcumin prevents fibrotic deposits by modulating collagen turnover, assembly and deposition in BLM-instilled rat lungs, and that curcumin treatment protects against BLM activation of macrophages by suppressing the release of TGF-beta1.	Curcumin	188-196	transforming growth factor, beta 1	Rattus norvegicus	284-293
34357837-7	2021	RESULTS: In vivo, curcumin reduced the size of the prostate, suppressed the expression of vimentin and TLR4, and increased the expression of E-cadherin and BAMBI in the LPS-induced BPH mouse model.	Curcumin	18-26	toll-like receptor 4	Mus musculus	103-107
34357837-7	2021	RESULTS: In vivo, curcumin reduced the size of the prostate, suppressed the expression of vimentin and TLR4, and increased the expression of E-cadherin and BAMBI in the LPS-induced BPH mouse model.	Curcumin	18-26	cadherin 1	Mus musculus	141-151
34357837-7	2021	RESULTS: In vivo, curcumin reduced the size of the prostate, suppressed the expression of vimentin and TLR4, and increased the expression of E-cadherin and BAMBI in the LPS-induced BPH mouse model.	Curcumin	18-26	BMP and activin membrane-bound inhibitor	Mus musculus	156-161
34357837-8	2021	Moreover, curcumin decreased the levels of IL-6 and TNF-alpha by 44.52 and 46.17%, respectively.	Curcumin	10-18	interleukin 6	Mus musculus	43-47
34357837-8	2021	Moreover, curcumin decreased the levels of IL-6 and TNF-alpha by 44.52 and 46.17%, respectively.	Curcumin	10-18	tumor necrosis factor	Mus musculus	52-61
34357837-9	2021	In vitro, curcumin attenuated cell proliferation, suppressed the expression of vimentin and TLR4, and increased the expression of E-cadherin and BAMBI in BPH-1 cells.	Curcumin	10-18	cadherin 1	Homo sapiens	130-140
34357837-9	2021	In vitro, curcumin attenuated cell proliferation, suppressed the expression of vimentin and TLR4, and increased the expression of E-cadherin and BAMBI in BPH-1 cells.	Curcumin	10-18	BMP and activin membrane bound inhibitor	Homo sapiens	145-150
34357837-10	2021	Furthermore, BAMBI knockdown reversed the expression of vimentin and E-cadherin induced by curcumin.	Curcumin	91-99	BMP and activin membrane bound inhibitor	Homo sapiens	13-18
34357837-10	2021	Furthermore, BAMBI knockdown reversed the expression of vimentin and E-cadherin induced by curcumin.	Curcumin	91-99	cadherin 1	Homo sapiens	69-79
34357837-12	2021	Furthermore, curcumin suppressed EMT by targeting BAMBI via the TLR4/BAMBI/TGF-beta1 signalling pathway in vitro, demonstrating its potential utility in BPH treatment.	Curcumin	13-21	BMP and activin membrane bound inhibitor	Homo sapiens	50-55
34357837-12	2021	Furthermore, curcumin suppressed EMT by targeting BAMBI via the TLR4/BAMBI/TGF-beta1 signalling pathway in vitro, demonstrating its potential utility in BPH treatment.	Curcumin	13-21	BMP and activin membrane bound inhibitor	Homo sapiens	69-74
34463926-0	2021	Curcumin Sensitizes Prolactinoma Cells to Bromocriptine by Activating the ERK/EGR1 and Inhibiting the AKT/GSK-3beta Signaling Pathway In Vitro and In Vivo.	Curcumin	0-8	Eph receptor B1	Rattus norvegicus	74-77
34463926-0	2021	Curcumin Sensitizes Prolactinoma Cells to Bromocriptine by Activating the ERK/EGR1 and Inhibiting the AKT/GSK-3beta Signaling Pathway In Vitro and In Vivo.	Curcumin	0-8	early growth response 1	Rattus norvegicus	78-82
34463926-0	2021	Curcumin Sensitizes Prolactinoma Cells to Bromocriptine by Activating the ERK/EGR1 and Inhibiting the AKT/GSK-3beta Signaling Pathway In Vitro and In Vivo.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
34751624-11	2021	Curcumin downregulated the TGF-beta1/Smad signaling pathway and inhibited Dragon and fibrogenic molecules in both rats and HK-2 cells.	Curcumin	0-8	transforming growth factor, beta 1	Rattus norvegicus	27-36
34749565-7	2022	CONCLUSIONS: Ustekinumab inhibits the inflammatory cytokines IL-12P40 and IL-23, while curcumin has antioxidant effects (increasing SOD, GPx, and CAT levels) with anti-inflammatory effects (decreasing the proinflammatory cytokine TNF-alpha and IL-17).	Curcumin	87-95	tumor necrosis factor	Rattus norvegicus	230-239
34899767-0	2021	Retraction: Curcumin Blunts IL-6 Dependent Endothelial-to-Mesenchymal Transition to Alleviate Renal Allograft Fibrosis Through Autophagy Activation.	Curcumin	12-20	interleukin 6	Homo sapiens	28-32
34831450-10	2021	Furthermore, histone acetylation inhibition by anacardic acid or curcumin reduces IL-6 production.	Curcumin	65-73	interleukin 6	Homo sapiens	82-86
34838781-7	2022	The corresponding diffusion coefficient and kinetic rate were 9.1 x 10-7 cm2 min-1 and 6.51 x 10-7 min-1, which were used as controlled release to achieve the desired curcumin constant release rate in the delivery system.	Curcumin	167-175	CD59 molecule (CD59 blood group)	Homo sapiens	77-88
34942962-6	2021	Additionally, we discussed the phytochemicals like curcumin, quercetin, resveratrol, epigallocatechin gallate, apigenin, sulforaphane, and ursolic acid that have effectively modified NRF2 signaling and prevented various diseases in both in vitro and in vivo models.	Curcumin	51-59	NFE2 like bZIP transcription factor 2	Homo sapiens	183-187
34749565-7	2022	CONCLUSIONS: Ustekinumab inhibits the inflammatory cytokines IL-12P40 and IL-23, while curcumin has antioxidant effects (increasing SOD, GPx, and CAT levels) with anti-inflammatory effects (decreasing the proinflammatory cytokine TNF-alpha and IL-17).	Curcumin	87-95	catalase	Rattus norvegicus	146-149
34806141-6	2022	As expected, caspase-3 staining also revealed a higher number of apoptotic cells in curcumin treatment groups at 24, 48, and 72 h compared to controls.	Curcumin	84-92	caspase 3	Homo sapiens	13-22
34806141-7	2022	The proportion of Caspase-3-stained cells in the control groups were 23%, 25%, and 24% and 59%, 60%, and 62% in the curcumin treatment groups at 24, 48, and 72 h, respectively.	Curcumin	116-124	caspase 3	Homo sapiens	18-27
34829695-4	2021	P-glycoprotein activity was determined in LS180 cells, incubated with 30 or 60 micromol/L of curcumin in the form of seven different formulations or native curcuma extract for 1 h. All formulations inhibited P-glycoprotein activity at both concentrations.	Curcumin	93-101	ATP binding cassette subfamily B member 1	Homo sapiens	208-222
34829695-7	2021	In conclusion, curcumin inhibits P-glycoprotein activity independently of its formulation.	Curcumin	15-23	ATP binding cassette subfamily B member 1	Homo sapiens	33-47
34833991-12	2021	Finally, the pro-inflammatory cytokines (IL-1beta, IL-6, and IL-8) released by PBMCs triggered by SARS-CoV-2 were decreased after treatment with curcumin.	Curcumin	145-153	interleukin 6	Homo sapiens	51-55
34833991-12	2021	Finally, the pro-inflammatory cytokines (IL-1beta, IL-6, and IL-8) released by PBMCs triggered by SARS-CoV-2 were decreased after treatment with curcumin.	Curcumin	145-153	C-X-C motif chemokine ligand 8	Homo sapiens	61-65
34867402-8	2021	This review focused on how curcumin exhibits anti-cancer effects through inhibition of RTKs and downstream signaling pathways like the MAPK, PI3K/Akt, JAK/STAT, and NF-kappaB pathways.	Curcumin	27-35	AKT serine/threonine kinase 1	Homo sapiens	146-149
34597657-9	2021	Moreover, the experimental approach verified curcumin as an effective therapeutic agent for HER2 positive breast cancer.	Curcumin	45-53	erb-b2 receptor tyrosine kinase 2	Homo sapiens	92-96
34600893-7	2021	Further, interaction profile for fungal CYP51B-curcumin was compared with human CYP3A4-curcumin, as there are published evidence describing curcumin as an inhibitor of human CYPs.	Curcumin	87-95	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	80-86
34555398-0	2021	Cardio-protective effect of tetrahydrocurcumin, the primary hydrogenated metabolite of curcumin in vivo and in vitro: Induction of apoptosis and autophagy via PI3K/AKT/mTOR pathways.	Curcumin	87-95	AKT serine/threonine kinase 1	Rattus norvegicus	164-167
34636389-5	2021	In addition, curcumin attenuated the increases in levels of miR-146a-5p and decreases in the expression of p-ERK signaling that would normally occur within CA1 regions of these depressed rats.	Curcumin	13-21	Eph receptor B1	Rattus norvegicus	109-112
34636389-7	2021	One of the mechanisms for these beneficial effects of curcumin appears to involve the miR-146a-5p/ERK signaling pathway within the hippocampal CA1 region.	Curcumin	54-62	Eph receptor B1	Rattus norvegicus	98-101
34599938-0	2021	Curcumin activation of nuclear factor E2-related factor 2 gene (Nrf2): Prophylactic and therapeutic effect in nonalcoholic steatohepatitis (NASH).	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	64-68
34599938-14	2021	Nuclear factor E2-related factor 2 gene (Nrf2) expression showed no changes in the HFD groups, however it showed upregulation in curcumin treated groups.	Curcumin	129-137	NFE2 like bZIP transcription factor 2	Rattus norvegicus	41-45
34599938-15	2021	Thus, the protective and therapeutic effect of curcumin could be induced through upregulation of the Nrf2 gene.	Curcumin	47-55	NFE2 like bZIP transcription factor 2	Rattus norvegicus	101-105
34773680-0	2022	Anti-lung cancer activities of 1,2,3-triazole curcumin derivatives via regulation of the MAPK/NF-kappaB/STAT3 signaling pathways.	Curcumin	46-54	nuclear factor kappa B subunit 1	Homo sapiens	94-103
34773680-0	2022	Anti-lung cancer activities of 1,2,3-triazole curcumin derivatives via regulation of the MAPK/NF-kappaB/STAT3 signaling pathways.	Curcumin	46-54	signal transducer and activator of transcription 3	Homo sapiens	104-109
34758851-0	2021	Curcumin prevents As3+-induced carcinogenesis through regulation of GSK3beta/Nrf2.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
34812266-10	2021	Curcumin pretreatment strikingly increased the level of SOD, CAT, GPx, GSH, IL-10, IFN-gamma, and FRAP and significantly decreased MDA, Cr, BUN, IL-8, TNF-alpha, IL-6, and myeloperoxidase (MPO) expressions in tissues.	Curcumin	0-8	catalase	Rattus norvegicus	61-64
34812266-10	2021	Curcumin pretreatment strikingly increased the level of SOD, CAT, GPx, GSH, IL-10, IFN-gamma, and FRAP and significantly decreased MDA, Cr, BUN, IL-8, TNF-alpha, IL-6, and myeloperoxidase (MPO) expressions in tissues.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	151-160
34812266-10	2021	Curcumin pretreatment strikingly increased the level of SOD, CAT, GPx, GSH, IL-10, IFN-gamma, and FRAP and significantly decreased MDA, Cr, BUN, IL-8, TNF-alpha, IL-6, and myeloperoxidase (MPO) expressions in tissues.	Curcumin	0-8	interleukin 6	Rattus norvegicus	162-166
34804186-10	2021	The molecular docking results showed that curcumin could be combined with AKT1, EGFR, and STAT3 more stably, and AKT1 has the strongest binding to curcumin.	Curcumin	42-50	AKT serine/threonine kinase 1	Homo sapiens	74-78
34804186-10	2021	The molecular docking results showed that curcumin could be combined with AKT1, EGFR, and STAT3 more stably, and AKT1 has the strongest binding to curcumin.	Curcumin	42-50	epidermal growth factor receptor	Homo sapiens	80-84
34804186-10	2021	The molecular docking results showed that curcumin could be combined with AKT1, EGFR, and STAT3 more stably, and AKT1 has the strongest binding to curcumin.	Curcumin	42-50	signal transducer and activator of transcription 3	Homo sapiens	90-95
34758851-17	2021	Furthermore, in vitro and in vivo results showed that curcumin induced cell apoptosis, and had anti-angiogenesis and anti-tumorigenesis effects as a result of activating the GSK-3beta/beta-TrCP ubiquitination pathway and subsequent decrease in Nrf2.	Curcumin	54-62	NFE2 like bZIP transcription factor 2	Homo sapiens	244-248
34758851-18	2021	CONCLUSIONS: Taken together, in the first stage, curcumin activated Nrf2, decreased ROS, and induced autophagy in normal cells to prevent As3+-induced cell transformation.	Curcumin	49-57	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
34758851-19	2021	In the second stage, curcumin promoted ROS and apoptosis and inhibited angiogenesis via inhibition of constitutive expression of Nrf2 in AsT to prevent tumorigenesis.	Curcumin	21-29	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
34758851-19	2021	In the second stage, curcumin promoted ROS and apoptosis and inhibited angiogenesis via inhibition of constitutive expression of Nrf2 in AsT to prevent tumorigenesis.	Curcumin	21-29	solute carrier family 17 member 5	Homo sapiens	137-140
34804186-10	2021	The molecular docking results showed that curcumin could be combined with AKT1, EGFR, and STAT3 more stably, and AKT1 has the strongest binding to curcumin.	Curcumin	42-50	AKT serine/threonine kinase 1	Homo sapiens	113-117
34804186-10	2021	The molecular docking results showed that curcumin could be combined with AKT1, EGFR, and STAT3 more stably, and AKT1 has the strongest binding to curcumin.	Curcumin	147-155	AKT serine/threonine kinase 1	Homo sapiens	74-78
34804186-10	2021	The molecular docking results showed that curcumin could be combined with AKT1, EGFR, and STAT3 more stably, and AKT1 has the strongest binding to curcumin.	Curcumin	147-155	epidermal growth factor receptor	Homo sapiens	80-84
34804186-10	2021	The molecular docking results showed that curcumin could be combined with AKT1, EGFR, and STAT3 more stably, and AKT1 has the strongest binding to curcumin.	Curcumin	147-155	signal transducer and activator of transcription 3	Homo sapiens	90-95
34804186-10	2021	The molecular docking results showed that curcumin could be combined with AKT1, EGFR, and STAT3 more stably, and AKT1 has the strongest binding to curcumin.	Curcumin	147-155	AKT serine/threonine kinase 1	Homo sapiens	113-117
34758851-5	2021	The cell-based assays and molecular docking findings revealed that curcumin has the best inhibitory activity against Keap1-4L7B.	Curcumin	67-75	kelch like ECH associated protein 1	Homo sapiens	117-122
34758851-6	2021	Co-immunoprecipitation (Co-IP) results indicated that curcumin is a potent Keap1 Kelch domain-dependent Nrf2 activator that stabilizes Nrf2 by hindering its ubiquitination.	Curcumin	54-62	kelch like ECH associated protein 1	Homo sapiens	75-80
34758851-6	2021	Co-immunoprecipitation (Co-IP) results indicated that curcumin is a potent Keap1 Kelch domain-dependent Nrf2 activator that stabilizes Nrf2 by hindering its ubiquitination.	Curcumin	54-62	NFE2 like bZIP transcription factor 2	Homo sapiens	104-108
34758851-6	2021	Co-immunoprecipitation (Co-IP) results indicated that curcumin is a potent Keap1 Kelch domain-dependent Nrf2 activator that stabilizes Nrf2 by hindering its ubiquitination.	Curcumin	54-62	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
34758851-7	2021	The increased activation of Nrf2 and its target antioxidant genes by curcumin could significantly decrease As3+-generated ROS.	Curcumin	69-77	NFE2 like bZIP transcription factor 2	Homo sapiens	28-32
34758851-9	2021	Knockdown of Nrf2 abolished curcumin-induced autophagy and downregulated ROS.	Curcumin	28-36	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
34758851-11	2021	These results demonstrated that curcumin prevents As3+-induced cell transformation by inducing autophagy via the activation of the Nrf2 signaling pathway in BEAS-2B cells.	Curcumin	32-40	NFE2 like bZIP transcription factor 2	Homo sapiens	131-135
34758851-13	2021	Overexpression of Nrf2 in AsT demonstrated that curcumin increased ROS levels and induced cell apoptosis via the downregulation of Nrf2.	Curcumin	48-56	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
34758851-13	2021	Overexpression of Nrf2 in AsT demonstrated that curcumin increased ROS levels and induced cell apoptosis via the downregulation of Nrf2.	Curcumin	48-56	solute carrier family 17 member 5	Homo sapiens	26-29
34758851-13	2021	Overexpression of Nrf2 in AsT demonstrated that curcumin increased ROS levels and induced cell apoptosis via the downregulation of Nrf2.	Curcumin	48-56	NFE2 like bZIP transcription factor 2	Homo sapiens	131-135
34758851-14	2021	Further studies showed that curcumin decreased the Nrf2 level in AsT by activating GSK-3beta to inhibit the activation of PI3K/AKT.	Curcumin	28-36	NFE2 like bZIP transcription factor 2	Homo sapiens	51-55
34758851-14	2021	Further studies showed that curcumin decreased the Nrf2 level in AsT by activating GSK-3beta to inhibit the activation of PI3K/AKT.	Curcumin	28-36	solute carrier family 17 member 5	Homo sapiens	65-68
34758851-14	2021	Further studies showed that curcumin decreased the Nrf2 level in AsT by activating GSK-3beta to inhibit the activation of PI3K/AKT.	Curcumin	28-36	AKT serine/threonine kinase 1	Homo sapiens	127-130
34758851-15	2021	Co-IP assay results showed that curcumin promoted the interaction of Nrf2 with the GSK-3beta/beta-TrCP axis and ubiquitin.	Curcumin	32-40	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
34758851-16	2021	Moreover, the inhibition of GSK-3beta reversed Nrf2 expression in curcumin-treated AsT, indicating that the decrease in Nrf2 is due to activation of the GSK-3beta/beta-TrCP ubiquitination pathway.	Curcumin	66-74	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
34758851-16	2021	Moreover, the inhibition of GSK-3beta reversed Nrf2 expression in curcumin-treated AsT, indicating that the decrease in Nrf2 is due to activation of the GSK-3beta/beta-TrCP ubiquitination pathway.	Curcumin	66-74	solute carrier family 17 member 5	Homo sapiens	83-86
34758851-16	2021	Moreover, the inhibition of GSK-3beta reversed Nrf2 expression in curcumin-treated AsT, indicating that the decrease in Nrf2 is due to activation of the GSK-3beta/beta-TrCP ubiquitination pathway.	Curcumin	66-74	NFE2 like bZIP transcription factor 2	Homo sapiens	120-124
34272803-0	2021	Curcumin functions as an anti-inflammatory and antioxidant agent on arsenic-induced hepatic and kidney injury by inhibiting MAPKs/NF-kappaB and activating Nrf2 pathways.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	130-139
34727633-0	2022	Curcumin represses lipid accumulation through inhibiting ERK1/2-PPAR-gamma signaling pathway and triggering apoptosis in porcine subcutaneous preadipocytes.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	57-63
34727633-0	2022	Curcumin represses lipid accumulation through inhibiting ERK1/2-PPAR-gamma signaling pathway and triggering apoptosis in porcine subcutaneous preadipocytes.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	64-74
34568882-3	2021	The hydrophobic curcumin was first loaded into the hydrophobic cavity of beta-cyclodextrin (beta-CD) as a core.	Curcumin	16-24	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	92-99
34568882-7	2021	Upon combination with HTCC, EWDP (both shell material and core nutraceuticals) could facilitate curcumin loading into the deeper beta-CD cavity site with admirable solubility improvement.	Curcumin	96-104	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	129-136
34795765-7	2021	Curcumin and BM-MSCs significantly (P < 0.05) improved the elevated TNF-alpha level and the lowered IL-10 level in the arthritic rats.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	68-77
34291863-4	2021	The aim of this study is to evaluate whether curcuminoids (curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin) could repress the expression of HER2 in HER2-overexpressing bladder cancer cells.	Curcumin	59-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	152-156
34291863-4	2021	The aim of this study is to evaluate whether curcuminoids (curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin) could repress the expression of HER2 in HER2-overexpressing bladder cancer cells.	Curcumin	59-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	160-164
34272803-0	2021	Curcumin functions as an anti-inflammatory and antioxidant agent on arsenic-induced hepatic and kidney injury by inhibiting MAPKs/NF-kappaB and activating Nrf2 pathways.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	155-159
34272803-6	2021	In addition, the levels of mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-kappaB) phosphorylation were declining while NRF2-signaling targets were increasing in mice liver and kidney by curcumin administration.	Curcumin	212-220	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-95
34272803-6	2021	In addition, the levels of mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-kappaB) phosphorylation were declining while NRF2-signaling targets were increasing in mice liver and kidney by curcumin administration.	Curcumin	212-220	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-106
34272803-6	2021	In addition, the levels of mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-kappaB) phosphorylation were declining while NRF2-signaling targets were increasing in mice liver and kidney by curcumin administration.	Curcumin	212-220	nuclear factor, erythroid derived 2, like 2	Mus musculus	145-149
34272803-7	2021	In conclusion, our results here suggest that curcumin could exert both anti-inflammatory and antioxidant functions on arsenic-induced hepatic and kidney injury by inhibiting MAPKs/NF-kappaB and activating Nrf2 pathways cooperatively.	Curcumin	45-53	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	180-189
34272803-7	2021	In conclusion, our results here suggest that curcumin could exert both anti-inflammatory and antioxidant functions on arsenic-induced hepatic and kidney injury by inhibiting MAPKs/NF-kappaB and activating Nrf2 pathways cooperatively.	Curcumin	45-53	nuclear factor, erythroid derived 2, like 2	Mus musculus	205-209
34510720-5	2021	Curcumin supplementation significantly reduced adiposity and total macrophage infiltration in WAT, compared to HFD group, consistent with reduced mRNA levels of M1 (Cd80, Cd38, Cd11c) and M2 (Arginase-1) macrophage markers.	Curcumin	0-8	CD80 antigen	Mus musculus	165-169
34510720-6	2021	Moreover, curcumin supplementation reduced expression of other key pro-inflammatory genes, such as NF-kappaB p65 subunit (p65), Stat1, Tlr4, and Il6, in WAT (p<0.05).	Curcumin	10-18	toll-like receptor 4	Mus musculus	135-139
34510720-6	2021	Moreover, curcumin supplementation reduced expression of other key pro-inflammatory genes, such as NF-kappaB p65 subunit (p65), Stat1, Tlr4, and Il6, in WAT (p<0.05).	Curcumin	10-18	interleukin 6	Mus musculus	145-148
34541720-7	2021	Serum levels of IFN-gamma (p = .52) and IL-17 (p = .11) decreased, while IL-4 (p = .12) and TGF-beta (p = .14) increased in the nano-curcumin group compared with placebo on day 14.	Curcumin	133-141	interferon gamma	Homo sapiens	16-25
34541720-7	2021	Serum levels of IFN-gamma (p = .52) and IL-17 (p = .11) decreased, while IL-4 (p = .12) and TGF-beta (p = .14) increased in the nano-curcumin group compared with placebo on day 14.	Curcumin	133-141	interleukin 4	Homo sapiens	73-77
34583226-5	2021	We found that the phytochemical compounds, such as curcumin, naringenin, sulforaphane, diallyl disulfide, mangiferin, oleanolic acid, umbelliferone, daphnetin, quercetin, isorhamnetin-3-O-galactoside, hesperidin, diammonium glycyrrhizinate, corilagin, shikonin, farrerol, and chenpi, had the potential to improve the Nrf2-ARE signaling thereby combat hepatotoxicity.	Curcumin	51-59	NFE2 like bZIP transcription factor 2	Homo sapiens	317-321
34776966-4	2021	Curcumin can inhibit many CYP enzymes in vitro, and so the inhibition of curcumin on CYP enzymes was compared by human liver microsomes, human hepatocytes, and hiHeps using UPLC-MS and the cocktail method.	Curcumin	0-8	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	26-29
34592487-8	2021	RESULTS: We found that Curcumin decreased the expression of IC ligands such as PD-L1, PD-L2, and Galectin-9 in HNSCC, leading to regulation of epithelial-to-mesenchymal transition-associated tumor invasion.	Curcumin	23-31	CD274 antigen	Mus musculus	79-84
34592487-8	2021	RESULTS: We found that Curcumin decreased the expression of IC ligands such as PD-L1, PD-L2, and Galectin-9 in HNSCC, leading to regulation of epithelial-to-mesenchymal transition-associated tumor invasion.	Curcumin	23-31	programmed cell death 1 ligand 2	Mus musculus	86-91
34592487-8	2021	RESULTS: We found that Curcumin decreased the expression of IC ligands such as PD-L1, PD-L2, and Galectin-9 in HNSCC, leading to regulation of epithelial-to-mesenchymal transition-associated tumor invasion.	Curcumin	23-31	lectin, galactose binding, soluble 9	Mus musculus	97-107
34592487-11	2021	Curcumin increased T-cell proliferation, tumor-infiltrating lymphocytes (TILs), and effector cytokines, and decreased the expression of PD-1, TIM-3, suppressive IC receptors and their ligands (PD-L1, PD-L2, and Galectin-9) in the TME, implying reinvigoration of the exhausted CD8+ T cells.	Curcumin	0-8	CD274 antigen	Mus musculus	193-198
34419542-0	2021	Levan enhanced the NF-kappaB suppression activity of an oral nano PLGA-curcumin formulation in breast cancer treatment.	Curcumin	71-79	nuclear factor kappa B subunit 1	Homo sapiens	19-28
34419542-3	2021	The hydrophobic polyphenol curcumin is shown to inhibit NF-kappaB and hence CR.	Curcumin	27-35	nuclear factor kappa B subunit 1	Homo sapiens	56-65
34419542-9	2021	The enhanced bioavailability of curcumin reduced the NF-kappaB levels elevated by GMC, both in vitro and in vivo.	Curcumin	32-40	nuclear factor kappa B subunit 1	Homo sapiens	53-62
34592487-11	2021	Curcumin increased T-cell proliferation, tumor-infiltrating lymphocytes (TILs), and effector cytokines, and decreased the expression of PD-1, TIM-3, suppressive IC receptors and their ligands (PD-L1, PD-L2, and Galectin-9) in the TME, implying reinvigoration of the exhausted CD8+ T cells.	Curcumin	0-8	programmed cell death 1 ligand 2	Mus musculus	200-205
34592487-11	2021	Curcumin increased T-cell proliferation, tumor-infiltrating lymphocytes (TILs), and effector cytokines, and decreased the expression of PD-1, TIM-3, suppressive IC receptors and their ligands (PD-L1, PD-L2, and Galectin-9) in the TME, implying reinvigoration of the exhausted CD8+ T cells.	Curcumin	0-8	lectin, galactose binding, soluble 9	Mus musculus	211-221
34776966-4	2021	Curcumin can inhibit many CYP enzymes in vitro, and so the inhibition of curcumin on CYP enzymes was compared by human liver microsomes, human hepatocytes, and hiHeps using UPLC-MS and the cocktail method.	Curcumin	73-81	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	85-88
34718429-13	2021	Treatment with 60 g/day curcumin granules for three months reduced the level of serum FABP3.	Curcumin	24-32	fatty acid binding protein 3	Homo sapiens	86-91
34708279-5	2021	The interaction energy values indicate that the interaction between Cur and AAT is stronger than the other studied complexes.	Curcumin	68-71	serpin family A member 1	Homo sapiens	76-79
34718429-14	2021	Curcumin also inhibited vascular fibrosis by reducing FABP3-enhanced FAO in AAFs.	Curcumin	0-8	fatty acid binding protein 3	Homo sapiens	54-59
34829745-12	2021	Morphological studies further confirmed that the curcumin and piperine nanogels penetrate the cells via endocytic pathways and induce caspase-3-related apoptosis.	Curcumin	49-57	caspase 3	Homo sapiens	134-143
34754622-18	2021	At a concentration of 20 muM curcumin cultured for 48 h, the expression of TGFB1 and GSTP1 in Hep3B cells was reduced significantly in qPCR analysis, and reduced TGFB1 protein expression was also found in Hep3B cells.	Curcumin	29-37	transforming growth factor beta 1	Homo sapiens	75-80
34754622-18	2021	At a concentration of 20 muM curcumin cultured for 48 h, the expression of TGFB1 and GSTP1 in Hep3B cells was reduced significantly in qPCR analysis, and reduced TGFB1 protein expression was also found in Hep3B cells.	Curcumin	29-37	transforming growth factor beta 1	Homo sapiens	162-167
34684883-2	2021	Curcumin reduces cell viability of renal cell carcinoma (RCC) cells when combined with TNF-related apoptosis-inducing ligand (TRAIL), a cytokine that specifically targets cancer cells, by helping overcome TRAIL resistance.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	126-131
34832850-3	2021	We found that both curcumin and resveratrol were efficient in reducing cancer cell survival and that they differently affected autophagy, ROS and activation of the PI3K/AKT/mTOR pathway.	Curcumin	19-27	AKT serine/threonine kinase 1	Homo sapiens	169-172
34832850-3	2021	We found that both curcumin and resveratrol were efficient in reducing cancer cell survival and that they differently affected autophagy, ROS and activation of the PI3K/AKT/mTOR pathway.	Curcumin	19-27	mechanistic target of rapamycin kinase	Homo sapiens	173-177
34832850-4	2021	Moreover, we found that resveratrol and curcumin in combination exerted a stronger cytotoxic effect in correlation with the induction of a stronger ER stress and the upregulation of pro-death UPR molecule CHOP.	Curcumin	40-48	DNA damage inducible transcript 3	Homo sapiens	205-209
34684883-2	2021	Curcumin reduces cell viability of renal cell carcinoma (RCC) cells when combined with TNF-related apoptosis-inducing ligand (TRAIL), a cytokine that specifically targets cancer cells, by helping overcome TRAIL resistance.	Curcumin	0-8	TNF superfamily member 10	Homo sapiens	205-210
34684883-4	2021	Similar compounds to curcumin with higher bioavailability, such as demethoxycurcumin (DMC) and 3,5-bis(2-fluorobenzylidene)-4-piperidone (EF24), can potentially have similar anticancer effects and show a similar synergy with TRAIL, thus reducing RCC viability.	Curcumin	21-29	TNF superfamily member 10	Homo sapiens	225-230
34649531-14	2021	At the doses tested, vegetal extracts had little effect: only curcumin slightly counteracted the effects of LPS on NGF and MMP-13 mRNA, and PGE2, IL-6 and MMP-13 release.	Curcumin	62-70	nerve growth factor	Homo sapiens	115-118
34657625-0	2021	Curcumin upregulates transforming growth factor-beta1, its receptors, and vascular endothelial growth factor expressions in an in vitro human gingival fibroblast wound healing model.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	74-108
34657625-3	2021	This study investigated whether curcumin regulates transforming growth factor (TGF)-beta1, type I TGF-beta receptor (TGF-betaRI), type II TGF-beta receptor (TGF-betaRII), and vascular endothelial growth factor (VEGF) expression in unwounded hGFs and an in vitro hGF wound healing model.	Curcumin	32-40	transforming growth factor beta 1	Homo sapiens	51-89
34657625-3	2021	This study investigated whether curcumin regulates transforming growth factor (TGF)-beta1, type I TGF-beta receptor (TGF-betaRI), type II TGF-beta receptor (TGF-betaRII), and vascular endothelial growth factor (VEGF) expression in unwounded hGFs and an in vitro hGF wound healing model.	Curcumin	32-40	vascular endothelial growth factor A	Homo sapiens	175-209
34657625-3	2021	This study investigated whether curcumin regulates transforming growth factor (TGF)-beta1, type I TGF-beta receptor (TGF-betaRI), type II TGF-beta receptor (TGF-betaRII), and vascular endothelial growth factor (VEGF) expression in unwounded hGFs and an in vitro hGF wound healing model.	Curcumin	32-40	vascular endothelial growth factor A	Homo sapiens	211-215
34657625-7	2021	PD98059 pretreatment was performed to determine whether extracellular signal-regulated kinase (ERK) signaling was required for regulation of gene expression by curcumin.	Curcumin	160-168	mitogen-activated protein kinase 1	Homo sapiens	56-93
34657625-11	2021	PD98059 significantly attenuated the curcumin-stimulated TGF-betaRI, TGF-betaRII, and VEGF expression, whereas it had no effect on TGF-beta1 expression.	Curcumin	37-45	vascular endothelial growth factor A	Homo sapiens	86-90
34657625-12	2021	CONCLUSIONS: Curcumin upregulated TGF-beta1, TGF-betaRI, TGF-betaRII, and VEGF expression in an in vitro hGF wound healing model.	Curcumin	13-21	transforming growth factor beta 1	Homo sapiens	34-43
34657625-12	2021	CONCLUSIONS: Curcumin upregulated TGF-beta1, TGF-betaRI, TGF-betaRII, and VEGF expression in an in vitro hGF wound healing model.	Curcumin	13-21	vascular endothelial growth factor A	Homo sapiens	74-78
34657625-13	2021	The ERK pathway is required for TGF-betaRI, TGF-betaRII, and VEGF induction by curcumin.	Curcumin	79-87	mitogen-activated protein kinase 1	Homo sapiens	4-7
34657625-13	2021	The ERK pathway is required for TGF-betaRI, TGF-betaRII, and VEGF induction by curcumin.	Curcumin	79-87	vascular endothelial growth factor A	Homo sapiens	61-65
34773965-8	2022	Furthermore, the data revealed that curcumin nanoformulation induces apoptosis in MDA-MB-468 cells through modulation of the expression of Bax, Bcl-2, Survivin, and Caspase-3.	Curcumin	36-44	BCL2 associated X, apoptosis regulator	Homo sapiens	139-142
34773965-8	2022	Furthermore, the data revealed that curcumin nanoformulation induces apoptosis in MDA-MB-468 cells through modulation of the expression of Bax, Bcl-2, Survivin, and Caspase-3.	Curcumin	36-44	BCL2 apoptosis regulator	Homo sapiens	144-149
34773965-8	2022	Furthermore, the data revealed that curcumin nanoformulation induces apoptosis in MDA-MB-468 cells through modulation of the expression of Bax, Bcl-2, Survivin, and Caspase-3.	Curcumin	36-44	caspase 3	Homo sapiens	165-174
34657625-0	2021	Curcumin upregulates transforming growth factor-beta1, its receptors, and vascular endothelial growth factor expressions in an in vitro human gingival fibroblast wound healing model.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	21-53
34331953-10	2021	We also found that Pref-1-stimulated fibrotic protein expressions were reduced by ATN-161, curcumin, U0126, and c-Jun siRNA in WI-38.	Curcumin	91-99	delta like non-canonical Notch ligand 1	Homo sapiens	19-25
34720999-0	2021	Curcumin Reduced H2O2- and G2385R-LRRK2-Induced Neurodegeneration.	Curcumin	0-8	leucine rich repeat kinase 2	Homo sapiens	34-39
34720999-7	2021	Treatment with curcumin (an antioxidant) significantly protected against G2385R-LRRK2-induced neurodegeneration by reducing mitochondrial ROS, caspase-3/7 activation, and PARP cleavage.	Curcumin	15-23	caspase 3	Homo sapiens	143-154
34675983-14	2021	After curcumin treatment, the AQP9 mRNA and AQP9 protein expression levels in U266 also increased.	Curcumin	6-14	aquaporin 9	Homo sapiens	30-34
34681684-7	2021	The combination of anthocyanins and curcumin resulted in a significant borderline reduction of NF-kappaB immunohistochemistry (IHC) expression in adenoma tissue (geometric mean ratio (GMR): 0.72; 95% confidence interval (CI): 0.51-1.00; p-value: 0.05) and a trend to a reduction of Ki-67 (GMR: 0.73; 95% CI: 0.50-1.08; p-value: 0.11).	Curcumin	36-44	nuclear factor kappa B subunit 1	Homo sapiens	95-104
34675983-14	2021	After curcumin treatment, the AQP9 mRNA and AQP9 protein expression levels in U266 also increased.	Curcumin	6-14	aquaporin 9	Homo sapiens	44-48
34675983-16	2021	Curcumin can enhance the killing effects of ATO on U266 by increasing the intracellular arsenic content, which may be related to the upregulation of AQP9 expression.	Curcumin	0-8	aquaporin 9	Homo sapiens	149-153
34681584-2	2021	The food-derived polyphenols curcumin (CC), resveratrol (RSV) and epigallocatechin gallate (EGCG) have anticancer immunologic functions, which, recently, have been proposed to act via the downregulation of PD-L1 expression.	Curcumin	29-37	CD274 molecule	Sus scrofa	206-211
34786240-0	2021	Systemic Curcumin-Human Serum Albumin in Proliferative Vitreoretinal Retinopathy: A Pilot Study.	Curcumin	9-17	albumin	Homo sapiens	30-37
34282279-0	2021	Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis.	Curcumin	0-8	microRNA 20a	Homo sapiens	100-107
34938916-6	2022	The bone tumor killing efficacy of the released curcumin from the carrier in combination with the hyperthermia was studied on MG-63 osteosarcoma cells through Alamar blue assay, live-dead staining and apoptosis caspase 3/7 activation kit.	Curcumin	48-56	caspase 3	Homo sapiens	211-222
34659400-7	2021	Curcumin administration significantly upregulated ZO-1 and claudin-1 protein levels and reduced Caco-2 cell apoptosis.	Curcumin	0-8	tight junction protein 1	Homo sapiens	50-54
34659400-8	2021	The protein levels of oxidative stress markers inducible nitric oxide synthase (iNOS) and gammaH2AX and ERS-induced apoptosis-related molecules C/EBP homologous protein (CHOP) and cleaved caspase-12 were significantly downregulated upon curcumin treatment.	Curcumin	237-245	nitric oxide synthase 2	Homo sapiens	47-78
34659400-8	2021	The protein levels of oxidative stress markers inducible nitric oxide synthase (iNOS) and gammaH2AX and ERS-induced apoptosis-related molecules C/EBP homologous protein (CHOP) and cleaved caspase-12 were significantly downregulated upon curcumin treatment.	Curcumin	237-245	nitric oxide synthase 2	Homo sapiens	80-84
34659400-8	2021	The protein levels of oxidative stress markers inducible nitric oxide synthase (iNOS) and gammaH2AX and ERS-induced apoptosis-related molecules C/EBP homologous protein (CHOP) and cleaved caspase-12 were significantly downregulated upon curcumin treatment.	Curcumin	237-245	DNA damage inducible transcript 3	Homo sapiens	144-168
34659400-8	2021	The protein levels of oxidative stress markers inducible nitric oxide synthase (iNOS) and gammaH2AX and ERS-induced apoptosis-related molecules C/EBP homologous protein (CHOP) and cleaved caspase-12 were significantly downregulated upon curcumin treatment.	Curcumin	237-245	DNA damage inducible transcript 3	Homo sapiens	170-174
34659400-9	2021	Furthermore, curcumin administration greatly blocked the protein kinase-like endoplasmic reticulum kinase- (PERK-) eukaryotic translation initiation factor 2alpha- (eIF2alpha-) activating transcription factor 4- (ATF4-) CHOP signaling pathway.	Curcumin	13-21	DNA damage inducible transcript 3	Homo sapiens	220-224
34282279-0	2021	Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis.	Curcumin	0-8	WT1 transcription factor	Homo sapiens	111-114
34282279-7	2021	The results showed that curcumin suppressed the resistance to Adriamycin, inhibited the expression of HOTAIR and WT1, and promoted the expression of miR-20a-5p in human acute leukemia cells (HL-60) or Adriamycin-resistant HL-60 cells (HL-60/ADR).	Curcumin	24-32	WT1 transcription factor	Homo sapiens	113-116
34282279-9	2021	Overexpression of HOTAIR reversed the regulatory effect of curcumin on apoptosis and migration and restored the effect of curcumin on inducing the expression of cleaved caspase3, Bax, and P27.	Curcumin	122-130	caspase 3	Homo sapiens	169-177
34282279-9	2021	Overexpression of HOTAIR reversed the regulatory effect of curcumin on apoptosis and migration and restored the effect of curcumin on inducing the expression of cleaved caspase3, Bax, and P27.	Curcumin	122-130	BCL2 associated X, apoptosis regulator	Homo sapiens	179-182
34358533-3	2021	Phytochemicals exhibit biphasic dose responses on cancer cells, activating at low dose, signaling pathways resulting in upregulation of vitagenes, as in the case of the Nrf2 pathway upregulated by hydroxytyrosol (HT) or curcumin and NAD/NADH-sirtuin-1 activated by resveratrol.	Curcumin	220-228	NFE2 like bZIP transcription factor 2	Homo sapiens	169-173
34282279-9	2021	Overexpression of HOTAIR reversed the regulatory effect of curcumin on apoptosis and migration and restored the effect of curcumin on inducing the expression of cleaved caspase3, Bax, and P27.	Curcumin	122-130	dynactin subunit 6	Homo sapiens	188-191
34282279-11	2021	Finally, curcumin inhibited Adriamycin resistance by suppressing the HOTAIR/miR-20a-5p/WT1 pathway in vivo.	Curcumin	9-17	microRNA 20a	Homo sapiens	76-83
34282279-11	2021	Finally, curcumin inhibited Adriamycin resistance by suppressing the HOTAIR/miR-20a-5p/WT1 pathway in vivo.	Curcumin	9-17	WT1 transcription factor	Homo sapiens	87-90
34282279-12	2021	In short, curcumin suppressed the proliferation and migration, blocked the cell cycle progression of AML cells, and sensitized AML cells to Adriamycin by regulating the HOTAIR/miR-20a-5p/WT1 axis.	Curcumin	10-18	microRNA 20a	Homo sapiens	176-183
34282279-12	2021	In short, curcumin suppressed the proliferation and migration, blocked the cell cycle progression of AML cells, and sensitized AML cells to Adriamycin by regulating the HOTAIR/miR-20a-5p/WT1 axis.	Curcumin	10-18	WT1 transcription factor	Homo sapiens	187-190
34517264-0	2021	Combination of curcumin with N-n-butyl haloperidol iodide inhibits hepatocellular carcinoma malignant proliferation by downregulating enhancer of zeste homolog 2 (EZH2) - lncRNA H19 to silence Wnt/beta-catenin signaling.	Curcumin	15-23	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	134-161
34374130-4	2021	In the current study, we demonstrate that curcumin can enhance 5-Fu chemosensitivity in HCC cells in vitro, increase the apoptosis rate, arrest the cell cycle at G2/M phase, and block the PI3k/AKT/mTOR signalling pathway by inhibiting the phosphorylation of PI3K and its downstream protein kinases.	Curcumin	42-50	thymoma viral proto-oncogene 1	Mus musculus	193-196
34517264-0	2021	Combination of curcumin with N-n-butyl haloperidol iodide inhibits hepatocellular carcinoma malignant proliferation by downregulating enhancer of zeste homolog 2 (EZH2) - lncRNA H19 to silence Wnt/beta-catenin signaling.	Curcumin	15-23	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	163-167
34233590-0	2021	Curcumin reverses hepatic epithelial mesenchymal transition induced by trichloroethylene by inhibiting IL-6R/STAT3.	Curcumin	0-8	interleukin 6 receptor	Homo sapiens	103-108
34233590-0	2021	Curcumin reverses hepatic epithelial mesenchymal transition induced by trichloroethylene by inhibiting IL-6R/STAT3.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	109-114
34233590-6	2021	In vivo studies have shown that curcumin significantly reduces the mortality of mice and control the occurrence and size of liver tumors by inhibiting the IL-6/STAT3 signaling pathway.	Curcumin	32-40	interleukin 6	Mus musculus	155-159
34233590-6	2021	In vivo studies have shown that curcumin significantly reduces the mortality of mice and control the occurrence and size of liver tumors by inhibiting the IL-6/STAT3 signaling pathway.	Curcumin	32-40	signal transducer and activator of transcription 3	Mus musculus	160-165
34233590-8	2021	In addition, curcumin significantly inhibited the protein expression of IL-6R, STAT3, snail, survivin, and cyclin D1 in THLE-2 and HepG2 cells induced by IL-6.	Curcumin	13-21	interleukin 6 receptor	Homo sapiens	72-77
34233590-8	2021	In addition, curcumin significantly inhibited the protein expression of IL-6R, STAT3, snail, survivin, and cyclin D1 in THLE-2 and HepG2 cells induced by IL-6.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	79-84
34233590-8	2021	In addition, curcumin significantly inhibited the protein expression of IL-6R, STAT3, snail, survivin, and cyclin D1 in THLE-2 and HepG2 cells induced by IL-6.	Curcumin	13-21	snail family transcriptional repressor 1	Homo sapiens	86-91
34233590-8	2021	In addition, curcumin significantly inhibited the protein expression of IL-6R, STAT3, snail, survivin, and cyclin D1 in THLE-2 and HepG2 cells induced by IL-6.	Curcumin	13-21	interleukin 6	Homo sapiens	154-158
34233590-9	2021	CONCLUSION: Curcumin has anti-inflammatory and anti-proliferative effects, and inhibits the development of HCC induced by TCE by reversing IL-6/STAT3 mediated EMT.	Curcumin	12-20	interleukin 6	Homo sapiens	139-143
34233590-9	2021	CONCLUSION: Curcumin has anti-inflammatory and anti-proliferative effects, and inhibits the development of HCC induced by TCE by reversing IL-6/STAT3 mediated EMT.	Curcumin	12-20	signal transducer and activator of transcription 3	Homo sapiens	144-149
34303741-4	2021	The nanofiber containing ATH and CR (PCN/CR/ATH) had stronger antioxidant and antimicrobial activities than those of nanofibers containing CR (PCN/CR) or ATH (PCN/ATH).	Curcumin	33-35	pericentrin	Homo sapiens	37-47
34586536-2	2022	The purpose from this study was to determine effects of curcumin nanoparticle into phytosomal formulation (PC) on the relative expression of DSPP, VEGF-A, HLA-G5, VCAM1, RelA and STAT3 genes which are among the most important factors influencing processes of immunomodulatory and tissue regenerative by DPSCs.	Curcumin	56-64	vascular endothelial growth factor A	Homo sapiens	147-153
34630845-0	2021	Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF-kappaB Suppression and NLRP3 Inflammasome Inhibition.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	117-126
34630845-9	2021	Mechanistically, both in vivo and in vitro studies confirmed that curcumin inhibited the activation of the NF-kappaB pathway.	Curcumin	66-74	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	107-116
34630845-12	2021	Our study suggested that curcumin reduced stroke-induced WM damage, improved functional outcomes, and attenuated microglial pyroptosis, at least partially, through suppression of the NF-kappaB/NLRP3 signaling pathway, further supporting curcumin as a potential therapeutic drug for stroke.	Curcumin	25-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	183-192
34586536-2	2022	The purpose from this study was to determine effects of curcumin nanoparticle into phytosomal formulation (PC) on the relative expression of DSPP, VEGF-A, HLA-G5, VCAM1, RelA and STAT3 genes which are among the most important factors influencing processes of immunomodulatory and tissue regenerative by DPSCs.	Curcumin	56-64	vascular cell adhesion molecule 1	Homo sapiens	163-168
34586536-2	2022	The purpose from this study was to determine effects of curcumin nanoparticle into phytosomal formulation (PC) on the relative expression of DSPP, VEGF-A, HLA-G5, VCAM1, RelA and STAT3 genes which are among the most important factors influencing processes of immunomodulatory and tissue regenerative by DPSCs.	Curcumin	56-64	signal transducer and activator of transcription 3	Homo sapiens	179-184
34351351-10	2021	Meanwhile, after curcumin treatment, mitochondrial membrane depolarization led to cytochrome c release from the mitochondria to the cytoplasm, and the ratio of Bax to Bcl-2 in HaCaT cells was also increased, which subsequently initiated the activation of caspase-3.	Curcumin	17-25	cytochrome c, somatic	Homo sapiens	82-94
34641401-5	2021	When synergy was observed, for example with curcumin and irinotecan, this was unrelated to MET induction, as assessed by changes in E-cadherin and vimentin expression.	Curcumin	44-52	cadherin 1	Homo sapiens	132-142
34641328-0	2021	Co-Treatments of Edible Curcumin from Turmeric Rhizomes and Chemotherapeutic Drugs on Cytotoxicity and FLT3 Protein Expression in Leukemic Stem Cells.	Curcumin	24-32	fms related receptor tyrosine kinase 3	Homo sapiens	103-107
34641328-1	2021	This study aims to enhance efficacy and reduce toxicity of the combination treatment of a drug and curcumin (Cur) on leukemic stem cell and leukemic cell lines, including KG-1a and KG-1 (FLT3+ LSCs), EoL-1 (FLT3+ LCs), and U937 (FLT3- LCs).	Curcumin	99-107	fms related receptor tyrosine kinase 3	Homo sapiens	187-191
34641328-1	2021	This study aims to enhance efficacy and reduce toxicity of the combination treatment of a drug and curcumin (Cur) on leukemic stem cell and leukemic cell lines, including KG-1a and KG-1 (FLT3+ LSCs), EoL-1 (FLT3+ LCs), and U937 (FLT3- LCs).	Curcumin	99-107	fms related receptor tyrosine kinase 3	Homo sapiens	207-211
34641328-1	2021	This study aims to enhance efficacy and reduce toxicity of the combination treatment of a drug and curcumin (Cur) on leukemic stem cell and leukemic cell lines, including KG-1a and KG-1 (FLT3+ LSCs), EoL-1 (FLT3+ LCs), and U937 (FLT3- LCs).	Curcumin	99-107	fms related receptor tyrosine kinase 3	Homo sapiens	229-233
34323243-0	2021	Curcumin enhances the membrane trafficking of the sodium iodide symporter and augments radioiodine uptake in dedifferentiated thyroid cancer cells via suppression of the PI3K-AKT signaling pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	175-178
34259235-0	2021	Enhanced anti-tumor efficacy by inhibiting HIF-1alpha to reprogram TAMs via core-satellite upconverting nanoparticles with curcumin mediated photodynamic therapy.	Curcumin	123-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-53
34259235-3	2021	Here, we reported NIR-triggered core-satellite upconverting nanoparticles (CSNPs) with curcumin (Cur) embedded as a difunctional photosensitizer, which could realize PDT in deep tumors with long excitation wavelength (980 nm) and reverse the immunosuppressive TME induced by up-regulated HIF-1alpha at the same time.	Curcumin	87-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	288-298
34569409-6	2021	Estimation of total number of intermolecular hydrogen bonds and binding free energy confirmed the stability of these Mpro-polyphenol complexes over Mpro-curcumin complex.	Curcumin	153-161	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	148-152
34569409-7	2021	Based on the greater binding affinity of polyphenols of pomegranate peel towards Mpro as compared to that of curcumin, pomegranate peel may be considered in any herbal medicinal formulation or may be incorporated into daily diets for prevention of COVID-19.Communicated by Ramaswamy H. Sarma.	Curcumin	109-117	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	81-85
34580340-0	2021	Curcumin inhibited hepatitis B viral entry through NTCP binding.	Curcumin	0-8	solute carrier family 10 member 1	Homo sapiens	51-55
34580340-7	2021	The CCM-induced suppression of HBV entry was directly correlated with the density of sodium-taurocholate co-transporting polypeptide (NTCP), a known host receptor for HBV entry.	Curcumin	4-7	solute carrier family 10 member 1	Homo sapiens	134-138
34580340-9	2021	The affinity between CCM and NTCP was measured using isothermal titration calorimetry (ITC).	Curcumin	21-24	solute carrier family 10 member 1	Homo sapiens	29-33
34491745-5	2021	SACD showed better encapsulation property than non-modified beta-CD to guest molecules such as methyl orange (up to 1.41-folds of beta-CD) and curcumin (with an encapsulation efficiency of up to 10 mg/g).	Curcumin	143-151	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	60-67
34323243-7	2021	Additionally, AKT knockdown phenocopied the restoration of thyroid-specific gene expression; however, ectopic expressed AKT inhibited curcumin-induced up-regulation of NIS protein, demonstrating that curcumin might improve radioiodine sensitivity via the inhibition of the PI3K-AKT-mTOR signaling pathway.	Curcumin	200-208	AKT serine/threonine kinase 1	Homo sapiens	14-17
34323243-7	2021	Additionally, AKT knockdown phenocopied the restoration of thyroid-specific gene expression; however, ectopic expressed AKT inhibited curcumin-induced up-regulation of NIS protein, demonstrating that curcumin might improve radioiodine sensitivity via the inhibition of the PI3K-AKT-mTOR signaling pathway.	Curcumin	200-208	AKT serine/threonine kinase 1	Homo sapiens	120-123
34323243-7	2021	Additionally, AKT knockdown phenocopied the restoration of thyroid-specific gene expression; however, ectopic expressed AKT inhibited curcumin-induced up-regulation of NIS protein, demonstrating that curcumin might improve radioiodine sensitivity via the inhibition of the PI3K-AKT-mTOR signaling pathway.	Curcumin	200-208	AKT serine/threonine kinase 1	Homo sapiens	278-281
34323243-7	2021	Additionally, AKT knockdown phenocopied the restoration of thyroid-specific gene expression; however, ectopic expressed AKT inhibited curcumin-induced up-regulation of NIS protein, demonstrating that curcumin might improve radioiodine sensitivity via the inhibition of the PI3K-AKT-mTOR signaling pathway.	Curcumin	200-208	mechanistic target of rapamycin kinase	Homo sapiens	282-286
34323243-7	2021	Additionally, AKT knockdown phenocopied the restoration of thyroid-specific gene expression; however, ectopic expressed AKT inhibited curcumin-induced up-regulation of NIS protein, demonstrating that curcumin might improve radioiodine sensitivity via the inhibition of the PI3K-AKT-mTOR signaling pathway.	Curcumin	134-142	AKT serine/threonine kinase 1	Homo sapiens	120-123
34351351-10	2021	Meanwhile, after curcumin treatment, mitochondrial membrane depolarization led to cytochrome c release from the mitochondria to the cytoplasm, and the ratio of Bax to Bcl-2 in HaCaT cells was also increased, which subsequently initiated the activation of caspase-3.	Curcumin	17-25	BCL2 associated X, apoptosis regulator	Homo sapiens	160-163
34351351-10	2021	Meanwhile, after curcumin treatment, mitochondrial membrane depolarization led to cytochrome c release from the mitochondria to the cytoplasm, and the ratio of Bax to Bcl-2 in HaCaT cells was also increased, which subsequently initiated the activation of caspase-3.	Curcumin	17-25	BCL2 apoptosis regulator	Homo sapiens	167-172
34351351-10	2021	Meanwhile, after curcumin treatment, mitochondrial membrane depolarization led to cytochrome c release from the mitochondria to the cytoplasm, and the ratio of Bax to Bcl-2 in HaCaT cells was also increased, which subsequently initiated the activation of caspase-3.	Curcumin	17-25	caspase 3	Homo sapiens	255-264
34577062-0	2021	Curcumin and Nano-Curcumin Mitigate Copper Neurotoxicity by Modulating Oxidative Stress, Inflammation, and Akt/GSK-3beta Signaling.	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
34567209-6	2021	Additionally, curcumin significantly downregulated CD11b+F4/80+TLR4+ macrophages and the protein levels of TLR2, TLR4, MyD88, NF-kappaBp65, p38MAPK, and AP-1 in colitis mice.	Curcumin	14-22	integrin alpha M	Mus musculus	51-56
34567209-6	2021	Additionally, curcumin significantly downregulated CD11b+F4/80+TLR4+ macrophages and the protein levels of TLR2, TLR4, MyD88, NF-kappaBp65, p38MAPK, and AP-1 in colitis mice.	Curcumin	14-22	toll-like receptor 4	Mus musculus	63-67
34567209-6	2021	Additionally, curcumin significantly downregulated CD11b+F4/80+TLR4+ macrophages and the protein levels of TLR2, TLR4, MyD88, NF-kappaBp65, p38MAPK, and AP-1 in colitis mice.	Curcumin	14-22	toll-like receptor 4	Mus musculus	113-117
34577062-0	2021	Curcumin and Nano-Curcumin Mitigate Copper Neurotoxicity by Modulating Oxidative Stress, Inflammation, and Akt/GSK-3beta Signaling.	Curcumin	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
34519034-6	2022	It turns out that the activity of lipase, phospholipase A2 (PLA2 ), phospholipase C (PLC), phospholipase D (PLD) and lipoxygenase (LOX) were significantly inhibited after curcumin-mediated PDT (P < 0.05).	Curcumin	171-179	phospholipase A2 group IB	Homo sapiens	42-58
34519034-6	2022	It turns out that the activity of lipase, phospholipase A2 (PLA2 ), phospholipase C (PLC), phospholipase D (PLD) and lipoxygenase (LOX) were significantly inhibited after curcumin-mediated PDT (P < 0.05).	Curcumin	171-179	phospholipase A2 group IB	Homo sapiens	60-64
34519034-6	2022	It turns out that the activity of lipase, phospholipase A2 (PLA2 ), phospholipase C (PLC), phospholipase D (PLD) and lipoxygenase (LOX) were significantly inhibited after curcumin-mediated PDT (P < 0.05).	Curcumin	171-179	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	91-106
34519034-6	2022	It turns out that the activity of lipase, phospholipase A2 (PLA2 ), phospholipase C (PLC), phospholipase D (PLD) and lipoxygenase (LOX) were significantly inhibited after curcumin-mediated PDT (P < 0.05).	Curcumin	171-179	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	108-111
34519034-8	2022	CONCLUSION: Curcumin-mediated PDT could delay oyster"s lipid degradation by inhibiting the activities of lipase, PLA2 , PLC, PLD and LOX, and by changing oyster"s microbial composition, reducing the relative abundance of Pseudoalteromonas and Psychrilyobacter.	Curcumin	12-20	phospholipase A2 group IB	Homo sapiens	113-117
34519034-8	2022	CONCLUSION: Curcumin-mediated PDT could delay oyster"s lipid degradation by inhibiting the activities of lipase, PLA2 , PLC, PLD and LOX, and by changing oyster"s microbial composition, reducing the relative abundance of Pseudoalteromonas and Psychrilyobacter.	Curcumin	12-20	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	125-128
34198046-10	2021	Apart from this, the present study also reports the unique contribution of curcumin in suppressing the mRNA levels of other MCMs like MCM4, MCM5, and MCM7 as well as of ORC1 and ORC2.	Curcumin	75-83	minichromosome maintenance complex component 5	Mus musculus	140-144
34573046-0	2021	Nano-Curcumin Prevents Cardiac Injury, Oxidative Stress and Inflammation, and Modulates TLR4/NF-kappaB and MAPK Signaling in Copper Sulfate-Intoxicated Rats.	Curcumin	5-13	toll-like receptor 4	Rattus norvegicus	88-92
34557512-6	2021	Since then, HIPEs stabilized by BCNs/SPI colloidal particles via the anti-solvent precipitation were used for the delivery of curcumin.	Curcumin	126-134	chromogranin A	Homo sapiens	37-40
34198046-10	2021	Apart from this, the present study also reports the unique contribution of curcumin in suppressing the mRNA levels of other MCMs like MCM4, MCM5, and MCM7 as well as of ORC1 and ORC2.	Curcumin	75-83	origin recognition complex, subunit 1	Mus musculus	169-173
34478838-8	2021	Curcumin supplementation in doses of 250-1500 mg/day over 8-12 weeks was observed to be associated with decreases in CRP and ESR in adult patients with rheumatoid arthritis and ulcerative colitis in comparison with the control group (WMD: -0.42; 95% CI: -0.59, -0.26, I2 = 94.3%; WMD: -55.96; 95% CI: -93.74, -18.17, I2 = 99.7%, respectively).	Curcumin	0-8	C-reactive protein	Homo sapiens	117-120
34478838-10	2021	CONCLUSIONS: Curcumin supplementation was associated with significant reductions in levels of CRP and ESR in patients with rheumatoid arthritis and ulcerative colitis.	Curcumin	13-21	C-reactive protein	Homo sapiens	94-97
34462629-4	2021	Importantly, the results of qPCR and immunochemistry showed that curcumin decreased M1 (iNOS, CCL2, and CD86) but increased M2 macrophage (Arg1, CD163, and CD206) marker expression in the myocardium of MI mice during the first 7 days post-MI.	Curcumin	65-73	nitric oxide synthase 2, inducible	Mus musculus	88-92
34144488-0	2021	Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly.	Curcumin	18-26	poly(ADP-ribose) polymerase 1	Homo sapiens	79-83
34144488-5	2021	Cur + Ola treatment inhibited PARylation, altered interaction of PARP-1 with representative BER proteins and arrested cells in S-phase.	Curcumin	0-5	poly(ADP-ribose) polymerase 1	Homo sapiens	65-71
34533799-0	2021	Mechanism of curcumin against myocardial ischaemia-reperfusion injury based on the P13K/Akt/mTOR signalling pathway.	Curcumin	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	88-91
34533799-1	2021	OBJECTIVE: To investigate the pharmacodynamic mechanism of curcumin against myocardial ischaemia-reperfusion injury by regulating the phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT)/rapamycin target protein (mTOR) signalling pathway.	Curcumin	59-67	AKT serine/threonine kinase 1	Rattus norvegicus	189-192
34533799-7	2021	Curcumin can also down-regulate the expression of Bax and up-regulate the protein levels of Bcl2, p-mTOR and p-AKT (p < 0.05 or p < 0.01).	Curcumin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	92-96
34533799-7	2021	Curcumin can also down-regulate the expression of Bax and up-regulate the protein levels of Bcl2, p-mTOR and p-AKT (p < 0.05 or p < 0.01).	Curcumin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	111-114
34533799-8	2021	CONCLUSIONS: This study shows that curcumin has a significant protective effect on myocardial ischaemia-reperfusion, and its mechanism may be related to the activation of PI3K/AKT/mTOR signalling pathway and inhibition of inflammation, apoptosis and oxidative stress.	Curcumin	35-43	AKT serine/threonine kinase 1	Rattus norvegicus	176-179
34405526-0	2021	Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-kappaB signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus.	Curcumin	0-8	advanced glycosylation end product-specific receptor	Mus musculus	54-58
34405526-0	2021	Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-kappaB signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus.	Curcumin	0-8	toll-like receptor 4	Mus musculus	59-63
34405526-0	2021	Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-kappaB signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	64-73
34405526-8	2021	Additionally, curcumin treatment could effectively decrease HMGB1 protein expression, advanced glycosylation end product-specific receptor (RAGE), Toll-like receptors-4 (TLR4) and nuclear factor kappa B (NF-kappaB) in transgenic mice hippocampus.	Curcumin	14-22	advanced glycosylation end product-specific receptor	Mus musculus	140-144
34405526-8	2021	Additionally, curcumin treatment could effectively decrease HMGB1 protein expression, advanced glycosylation end product-specific receptor (RAGE), Toll-like receptors-4 (TLR4) and nuclear factor kappa B (NF-kappaB) in transgenic mice hippocampus.	Curcumin	14-22	toll-like receptor 4	Mus musculus	147-168
34405526-8	2021	Additionally, curcumin treatment could effectively decrease HMGB1 protein expression, advanced glycosylation end product-specific receptor (RAGE), Toll-like receptors-4 (TLR4) and nuclear factor kappa B (NF-kappaB) in transgenic mice hippocampus.	Curcumin	14-22	toll-like receptor 4	Mus musculus	170-174
34405526-8	2021	Additionally, curcumin treatment could effectively decrease HMGB1 protein expression, advanced glycosylation end product-specific receptor (RAGE), Toll-like receptors-4 (TLR4) and nuclear factor kappa B (NF-kappaB) in transgenic mice hippocampus.	Curcumin	14-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	180-202
34405526-8	2021	Additionally, curcumin treatment could effectively decrease HMGB1 protein expression, advanced glycosylation end product-specific receptor (RAGE), Toll-like receptors-4 (TLR4) and nuclear factor kappa B (NF-kappaB) in transgenic mice hippocampus.	Curcumin	14-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	204-213
34405526-11	2021	Taken together, these data indicate that oral administration of curcumin may be a promising agent to attenuate memory deterioration in AD mice, probably inhibiting the HMGB1-RAGE/TLR4-NF-kappaB inflammatory signalling pathway.	Curcumin	64-72	advanced glycosylation end product-specific receptor	Mus musculus	174-178
34405526-11	2021	Taken together, these data indicate that oral administration of curcumin may be a promising agent to attenuate memory deterioration in AD mice, probably inhibiting the HMGB1-RAGE/TLR4-NF-kappaB inflammatory signalling pathway.	Curcumin	64-72	toll-like receptor 4	Mus musculus	179-183
34405526-11	2021	Taken together, these data indicate that oral administration of curcumin may be a promising agent to attenuate memory deterioration in AD mice, probably inhibiting the HMGB1-RAGE/TLR4-NF-kappaB inflammatory signalling pathway.	Curcumin	64-72	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	184-193
34097977-0	2021	Curcumin loaded chitosan-protamine nanoparticles revealed antitumor activity via suppression of NF-kappaB, proinflammatory cytokines and Bcl-2 gene expression in the breast cancer cells.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	96-105
34097977-0	2021	Curcumin loaded chitosan-protamine nanoparticles revealed antitumor activity via suppression of NF-kappaB, proinflammatory cytokines and Bcl-2 gene expression in the breast cancer cells.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	137-142
34577580-6	2021	Our network and pathway analyses implicated the four targets of AKT1, RELA, MAPK1, and TP53 that could be involved in the inhibitory effects of curcumin on influenza.	Curcumin	144-152	AKT serine/threonine kinase 1	Homo sapiens	64-68
34577580-6	2021	Our network and pathway analyses implicated the four targets of AKT1, RELA, MAPK1, and TP53 that could be involved in the inhibitory effects of curcumin on influenza.	Curcumin	144-152	mitogen-activated protein kinase 1	Homo sapiens	76-81
34577580-6	2021	Our network and pathway analyses implicated the four targets of AKT1, RELA, MAPK1, and TP53 that could be involved in the inhibitory effects of curcumin on influenza.	Curcumin	144-152	tumor protein p53	Homo sapiens	87-91
34577580-7	2021	The binding energy calculations of each ligand-target interaction in the molecular docking showed that curcumin bound to AKT1 with the highest affinity among the four targets.	Curcumin	103-111	AKT serine/threonine kinase 1	Homo sapiens	121-125
34577580-9	2021	Influenza virus induction increased the level of mRNA expression of AKT in MDCK cells, and the level was attenuated by curcumin treatment.	Curcumin	119-127	AKT serine/threonine kinase 1	Homo sapiens	68-71
34512368-3	2021	In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53.	Curcumin	103-111	mitogen-activated protein kinase kinase 7	Homo sapiens	292-295
34512368-3	2021	In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53.	Curcumin	103-111	mitogen-activated protein kinase 1	Homo sapiens	296-299
34512368-3	2021	In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53.	Curcumin	103-111	AKT serine/threonine kinase 1	Homo sapiens	306-309
34439562-7	2021	Moreover, the curcumin-induced reduction in ROS generation decreased the nuclear translocation of Nuclear factor erythroid-2-related factor 2 (Nrf2) and the expression of phase-II detoxifying enzymes.	Curcumin	14-22	NFE2 like bZIP transcription factor 2	Homo sapiens	98-141
34439562-7	2021	Moreover, the curcumin-induced reduction in ROS generation decreased the nuclear translocation of Nuclear factor erythroid-2-related factor 2 (Nrf2) and the expression of phase-II detoxifying enzymes.	Curcumin	14-22	NFE2 like bZIP transcription factor 2	Homo sapiens	143-147
34153850-4	2021	Cell behavior and viability, reactive oxygen species production, and the protein expression of the kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2(Nrf2)/antioxidant response element (ARE) pathway were examined; the Keap1/Nrf2/ARE pathway is crucial anti-oxidative pathway of curcumin.	Curcumin	315-323	kelch like ECH associated protein 1	Homo sapiens	255-260
34153850-6	2021	In addition, curcumin pretreatment significantly increased the expression of nuclear Nrf2, and the productions of superoxide dismutase 1 and heme oxygenase-1, which were the target anti-oxidative enzymes of the Keap1/Nrf2/ARE pathway.	Curcumin	13-21	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
34153850-6	2021	In addition, curcumin pretreatment significantly increased the expression of nuclear Nrf2, and the productions of superoxide dismutase 1 and heme oxygenase-1, which were the target anti-oxidative enzymes of the Keap1/Nrf2/ARE pathway.	Curcumin	13-21	superoxide dismutase 1	Homo sapiens	114-136
34153850-6	2021	In addition, curcumin pretreatment significantly increased the expression of nuclear Nrf2, and the productions of superoxide dismutase 1 and heme oxygenase-1, which were the target anti-oxidative enzymes of the Keap1/Nrf2/ARE pathway.	Curcumin	13-21	kelch like ECH associated protein 1	Homo sapiens	211-216
34153850-6	2021	In addition, curcumin pretreatment significantly increased the expression of nuclear Nrf2, and the productions of superoxide dismutase 1 and heme oxygenase-1, which were the target anti-oxidative enzymes of the Keap1/Nrf2/ARE pathway.	Curcumin	13-21	NFE2 like bZIP transcription factor 2	Homo sapiens	217-221
34153850-8	2021	The activation of Keap1/Nrf2/ARE pathway by curcumin was crucial for CECs to improve their anti-oxidative capacity.	Curcumin	44-52	kelch like ECH associated protein 1	Homo sapiens	18-23
34153850-8	2021	The activation of Keap1/Nrf2/ARE pathway by curcumin was crucial for CECs to improve their anti-oxidative capacity.	Curcumin	44-52	NFE2 like bZIP transcription factor 2	Homo sapiens	24-28
34331475-0	2021	Curcumin induced G2/M cycle arrest in SK-N-SH neuroblastoma cells through the ROS-mediated p53 signaling pathway.	Curcumin	0-8	tumor protein p53	Homo sapiens	91-94
34331475-5	2021	Curcumin induced SK-N-SH cell apoptosis by G2/M cycle arrest and activated caspase-3 activity.	Curcumin	0-8	caspase 3	Homo sapiens	75-84
34331475-6	2021	Furthermore, curcumin promoted the overproduction of intracellular ROS and apoptosis induced by activating p53 and Bcl-2 signal pathways.	Curcumin	13-21	tumor protein p53	Homo sapiens	107-110
34331475-6	2021	Furthermore, curcumin promoted the overproduction of intracellular ROS and apoptosis induced by activating p53 and Bcl-2 signal pathways.	Curcumin	13-21	BCL2 apoptosis regulator	Homo sapiens	115-120
34862868-10	2021	There was insignificant difference (P>0.05) in Bax expression of tumor tissue of control group, curcumin group and oxaliplatin group while in curcumin plus oxaliplatin group, it was significantly increased.	Curcumin	96-104	BCL2 associated X, apoptosis regulator	Homo sapiens	47-50
34862868-10	2021	There was insignificant difference (P>0.05) in Bax expression of tumor tissue of control group, curcumin group and oxaliplatin group while in curcumin plus oxaliplatin group, it was significantly increased.	Curcumin	142-150	BCL2 associated X, apoptosis regulator	Homo sapiens	47-50
34862868-11	2021	The expression of Bcl-2 in oxaliplatin group was significantly lower and the value of Bcl-2/Bax in curcumin plus oxaliplatin group was decreased most obviously.	Curcumin	99-107	BCL2 apoptosis regulator	Homo sapiens	18-23
34862868-11	2021	The expression of Bcl-2 in oxaliplatin group was significantly lower and the value of Bcl-2/Bax in curcumin plus oxaliplatin group was decreased most obviously.	Curcumin	99-107	BCL2 apoptosis regulator	Homo sapiens	86-91
34862868-11	2021	The expression of Bcl-2 in oxaliplatin group was significantly lower and the value of Bcl-2/Bax in curcumin plus oxaliplatin group was decreased most obviously.	Curcumin	99-107	BCL2 associated X, apoptosis regulator	Homo sapiens	92-95
34497845-9	2021	In addition, curcumin treatment suppressed the PI3K/AKT pathway in PASMCs and regulated the expression of antiproliferative genes.	Curcumin	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	52-55
34484389-0	2021	Efficacy and Safety of Curcumin Supplement on Improvement of Insulin Resistance in People with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.	Curcumin	23-31	insulin	Homo sapiens	61-68
34484389-10	2021	Conclusion: Based on the current evidence, curcumin may assist in improving the insulin resistance, glycemic control, and decreased TG and TC in patients with T2DM.	Curcumin	43-51	insulin	Homo sapiens	80-87
34462629-4	2021	Importantly, the results of qPCR and immunochemistry showed that curcumin decreased M1 (iNOS, CCL2, and CD86) but increased M2 macrophage (Arg1, CD163, and CD206) marker expression in the myocardium of MI mice during the first 7 days post-MI.	Curcumin	65-73	CD86 antigen	Mus musculus	104-108
34462629-4	2021	Importantly, the results of qPCR and immunochemistry showed that curcumin decreased M1 (iNOS, CCL2, and CD86) but increased M2 macrophage (Arg1, CD163, and CD206) marker expression in the myocardium of MI mice during the first 7 days post-MI.	Curcumin	65-73	CD163 antigen	Mus musculus	145-150
34462629-5	2021	And flow cytometry analysis indicated that curcumin suppressed M1 (CD45+Gr-1-CD11b+iNOS+ cells) but enhanced M2 macrophage (CD45+Gr-1-CD11b+Arg+ cells) expansion in the myocardium of MI mice during the first 7 days post-MI.	Curcumin	43-51	integrin alpha M	Mus musculus	77-82
34462629-5	2021	And flow cytometry analysis indicated that curcumin suppressed M1 (CD45+Gr-1-CD11b+iNOS+ cells) but enhanced M2 macrophage (CD45+Gr-1-CD11b+Arg+ cells) expansion in the myocardium of MI mice during the first 7 days post-MI.	Curcumin	43-51	nitric oxide synthase 2, inducible	Mus musculus	83-87
34462629-5	2021	And flow cytometry analysis indicated that curcumin suppressed M1 (CD45+Gr-1-CD11b+iNOS+ cells) but enhanced M2 macrophage (CD45+Gr-1-CD11b+Arg+ cells) expansion in the myocardium of MI mice during the first 7 days post-MI.	Curcumin	43-51	integrin alpha M	Mus musculus	134-139
34462629-6	2021	In vitro, curcumin decreased LPS/IFNgamma-elevated M1 macrophage marker (iNOS and CD86) expression and the proportion of M1 macrophages (iNOS+F4/80+ cells) but increased LPS/IFNgamma-suppressed M2 macrophage marker (Arg1 and CD206) expression and the proportion of M2 macrophages (Arg1+F4/80+ cells).	Curcumin	10-18	interferon gamma	Mus musculus	33-41
34462629-6	2021	In vitro, curcumin decreased LPS/IFNgamma-elevated M1 macrophage marker (iNOS and CD86) expression and the proportion of M1 macrophages (iNOS+F4/80+ cells) but increased LPS/IFNgamma-suppressed M2 macrophage marker (Arg1 and CD206) expression and the proportion of M2 macrophages (Arg1+F4/80+ cells).	Curcumin	10-18	nitric oxide synthase 2, inducible	Mus musculus	73-77
34462629-6	2021	In vitro, curcumin decreased LPS/IFNgamma-elevated M1 macrophage marker (iNOS and CD86) expression and the proportion of M1 macrophages (iNOS+F4/80+ cells) but increased LPS/IFNgamma-suppressed M2 macrophage marker (Arg1 and CD206) expression and the proportion of M2 macrophages (Arg1+F4/80+ cells).	Curcumin	10-18	CD86 antigen	Mus musculus	82-86
34462629-6	2021	In vitro, curcumin decreased LPS/IFNgamma-elevated M1 macrophage marker (iNOS and CD86) expression and the proportion of M1 macrophages (iNOS+F4/80+ cells) but increased LPS/IFNgamma-suppressed M2 macrophage marker (Arg1 and CD206) expression and the proportion of M2 macrophages (Arg1+F4/80+ cells).	Curcumin	10-18	nitric oxide synthase 2, inducible	Mus musculus	137-141
34462629-6	2021	In vitro, curcumin decreased LPS/IFNgamma-elevated M1 macrophage marker (iNOS and CD86) expression and the proportion of M1 macrophages (iNOS+F4/80+ cells) but increased LPS/IFNgamma-suppressed M2 macrophage marker (Arg1 and CD206) expression and the proportion of M2 macrophages (Arg1+F4/80+ cells).	Curcumin	10-18	interferon gamma	Mus musculus	174-182
34458134-0	2021	Curcumin in Combination With Omacetaxine Suppress Lymphoma Cell Growth, Migration, Invasion, and Angiogenesis via Inhibition of VEGF/Akt Signaling Pathway.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	128-132
34456629-0	2021	Curcumin Antagonizes Glucose Fluctuation-Induced Renal Injury by Inhibiting Aerobic Glycolysis via the miR-489/LDHA Pathway.	Curcumin	0-8	lactate dehydrogenase A	Homo sapiens	111-115
34443551-0	2021	Preparation of Curcumin-Eudragit  E PO Solid Dispersions with Gradient Temperature through Hot-Melt Extrusion.	Curcumin	15-23	alcohol dehydrogenase, iron containing, 1	Rattus norvegicus	91-94
34458861-5	2021	The reduced fat accumulation by curcumin was dependent on lipogenesis-associated genes, sbp-1 (encodes the homolog of sterol response element binding proteins) and fat-6 (encodes a homolog of stearoyl-CoA desaturase), as curcumin significantly down-regulated the expression levels of these two genes and its fat reduction effect was nulled by the mutation of sbp-1 and fat-6.	Curcumin	32-40	BHLH domain-containing protein	Caenorhabditis elegans	88-93
34458861-5	2021	The reduced fat accumulation by curcumin was dependent on lipogenesis-associated genes, sbp-1 (encodes the homolog of sterol response element binding proteins) and fat-6 (encodes a homolog of stearoyl-CoA desaturase), as curcumin significantly down-regulated the expression levels of these two genes and its fat reduction effect was nulled by the mutation of sbp-1 and fat-6.	Curcumin	32-40	BHLH domain-containing protein	Caenorhabditis elegans	359-364
34458861-5	2021	The reduced fat accumulation by curcumin was dependent on lipogenesis-associated genes, sbp-1 (encodes the homolog of sterol response element binding proteins) and fat-6 (encodes a homolog of stearoyl-CoA desaturase), as curcumin significantly down-regulated the expression levels of these two genes and its fat reduction effect was nulled by the mutation of sbp-1 and fat-6.	Curcumin	221-229	BHLH domain-containing protein	Caenorhabditis elegans	88-93
34458861-5	2021	The reduced fat accumulation by curcumin was dependent on lipogenesis-associated genes, sbp-1 (encodes the homolog of sterol response element binding proteins) and fat-6 (encodes a homolog of stearoyl-CoA desaturase), as curcumin significantly down-regulated the expression levels of these two genes and its fat reduction effect was nulled by the mutation of sbp-1 and fat-6.	Curcumin	221-229	BHLH domain-containing protein	Caenorhabditis elegans	359-364
34458861-6	2021	Additionally, the increased locomotive activity by curcumin was dependent on sbp-1.	Curcumin	51-59	BHLH domain-containing protein	Caenorhabditis elegans	77-82
34458861-7	2021	Current results suggest that curcumin decreases fat accumulation by inhibiting sbp-1/fat-6-mediated signaling in Caenorhabditis elegans.	Curcumin	29-37	BHLH domain-containing protein	Caenorhabditis elegans	79-84
34439544-3	2021	Recently, structural features from curcumin and diallyl sulfide have been combined in a nature-inspired hybrid (NIH1), which has been described to activate transcription nuclear factor erythroid-2-related factor-2 (Nrf2), the master regulator of the antioxidant response, in different cell lines.	Curcumin	35-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	170-213
34439544-3	2021	Recently, structural features from curcumin and diallyl sulfide have been combined in a nature-inspired hybrid (NIH1), which has been described to activate transcription nuclear factor erythroid-2-related factor-2 (Nrf2), the master regulator of the antioxidant response, in different cell lines.	Curcumin	35-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	215-219
34323067-7	2021	In OPA-stimulated HepG2 cells, curcumin rectified the dysregulated expression of SLC13A5/ACLY possibly via the AMPK-mTOR signaling pathway.	Curcumin	31-39	mechanistic target of rapamycin kinase	Homo sapiens	116-120
34458134-0	2021	Curcumin in Combination With Omacetaxine Suppress Lymphoma Cell Growth, Migration, Invasion, and Angiogenesis via Inhibition of VEGF/Akt Signaling Pathway.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	133-136
34458134-11	2021	Conclusion: Our findings indicated that combination of HHT and curcumin could inhibit lymphoma cell growth and angiogenesis via inhibition of VEGF/Akt signaling pathway.	Curcumin	63-71	vascular endothelial growth factor A	Homo sapiens	142-146
34458134-11	2021	Conclusion: Our findings indicated that combination of HHT and curcumin could inhibit lymphoma cell growth and angiogenesis via inhibition of VEGF/Akt signaling pathway.	Curcumin	63-71	AKT serine/threonine kinase 1	Homo sapiens	147-150
34330457-6	2021	RESULTS: The curcumin group showed a significant increase in catalase activity (Delta = 1.13 +- 2.87 versus Delta = -1.08 +- 2.68; p = 0.048) and preserved glutathione peroxidase activity (Delta = -4.23 +- 11.50 versus Delta = -14.44 +- 13.96; p < 0.01) compared with the placebo group.	Curcumin	13-21	catalase	Homo sapiens	61-69
34409100-5	2021	Curcumin can also downregulate cellular PI4KB and interrupt its colocalization in viral IBs.	Curcumin	0-8	phosphatidylinositol 4-kinase beta	Homo sapiens	40-45
34408780-0	2021	Curcumin Inhibits HGF-Induced EMT by Regulating c-MET-Dependent PI3K/Akt/mTOR Signaling Pathways in Meningioma.	Curcumin	0-8	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	48-53
34408780-0	2021	Curcumin Inhibits HGF-Induced EMT by Regulating c-MET-Dependent PI3K/Akt/mTOR Signaling Pathways in Meningioma.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	69-72
34408780-0	2021	Curcumin Inhibits HGF-Induced EMT by Regulating c-MET-Dependent PI3K/Akt/mTOR Signaling Pathways in Meningioma.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	73-77
34408780-4	2021	We found that curcumin blocks hepatocyte growth factor- (HGF-) induced proliferation, migration, invasion, and EMT of human malignant meningioma cells by regulating the PI3K/Akt/mTOR signaling pathway.	Curcumin	14-22	AKT serine/threonine kinase 1	Homo sapiens	174-177
34408780-4	2021	We found that curcumin blocks hepatocyte growth factor- (HGF-) induced proliferation, migration, invasion, and EMT of human malignant meningioma cells by regulating the PI3K/Akt/mTOR signaling pathway.	Curcumin	14-22	mechanistic target of rapamycin kinase	Homo sapiens	178-182
34408780-8	2021	In conclusion, curcumin inhibits HGF-induced EMT by targeting c-MET and subsequently blocking the PI3K/Akt/mTOR pathway.	Curcumin	15-23	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	62-67
34408780-8	2021	In conclusion, curcumin inhibits HGF-induced EMT by targeting c-MET and subsequently blocking the PI3K/Akt/mTOR pathway.	Curcumin	15-23	AKT serine/threonine kinase 1	Homo sapiens	103-106
34408780-8	2021	In conclusion, curcumin inhibits HGF-induced EMT by targeting c-MET and subsequently blocking the PI3K/Akt/mTOR pathway.	Curcumin	15-23	mechanistic target of rapamycin kinase	Homo sapiens	107-111
34440159-0	2021	Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity.	Curcumin	65-73	membrane metalloendopeptidase	Homo sapiens	111-121
34440159-4	2021	AIMS: Ten hydroxylated monocarbonyl curcumin derivatives were designed, synthesized and evaluated for their NEP upregulating potential using sensitive fluorescence-based Abeta digestion and inhibition assays.	Curcumin	36-44	membrane metalloendopeptidase	Homo sapiens	108-111
34194553-0	2021	Curcumin inhibits the viability, migration and invasion of papillary thyroid cancer cells by regulating the miR-301a-3p/STAT3 axis.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	120-125
34194553-8	2021	Additionally, curcumin decreased STAT3 expression by upregulating miR-301a-3p expression, and the inhibition of miR-301a-3p and the overexpression of STAT3 reversed the effects of curcumin on cell viability, migration and invasion, and MMP-2, MMP-9 and EMT marker expression in TPC-1 cells.	Curcumin	180-188	signal transducer and activator of transcription 3	Homo sapiens	150-155
34194553-8	2021	Additionally, curcumin decreased STAT3 expression by upregulating miR-301a-3p expression, and the inhibition of miR-301a-3p and the overexpression of STAT3 reversed the effects of curcumin on cell viability, migration and invasion, and MMP-2, MMP-9 and EMT marker expression in TPC-1 cells.	Curcumin	14-22	signal transducer and activator of transcription 3	Homo sapiens	33-38
34194553-9	2021	Furthermore, curcumin suppressed the JAK/STAT signaling pathway through the miR-301a-3p/STAT3 axis.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	41-45
34194553-9	2021	Furthermore, curcumin suppressed the JAK/STAT signaling pathway through the miR-301a-3p/STAT3 axis.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	88-93
34194553-8	2021	Additionally, curcumin decreased STAT3 expression by upregulating miR-301a-3p expression, and the inhibition of miR-301a-3p and the overexpression of STAT3 reversed the effects of curcumin on cell viability, migration and invasion, and MMP-2, MMP-9 and EMT marker expression in TPC-1 cells.	Curcumin	14-22	signal transducer and activator of transcription 3	Homo sapiens	150-155
34194553-10	2021	The data of the present study indicated that curcumin could inhibit the viability, migration and invasion of TPC-1 cells by regulating the miR-301a-3p/STAT3 axis.	Curcumin	45-53	signal transducer and activator of transcription 3	Homo sapiens	151-156
34194553-8	2021	Additionally, curcumin decreased STAT3 expression by upregulating miR-301a-3p expression, and the inhibition of miR-301a-3p and the overexpression of STAT3 reversed the effects of curcumin on cell viability, migration and invasion, and MMP-2, MMP-9 and EMT marker expression in TPC-1 cells.	Curcumin	180-188	signal transducer and activator of transcription 3	Homo sapiens	33-38
34169637-0	2021	Curcumin inhibits adverse psychological stress-induced proliferation and invasion of glioma cells via down-regulating the ERK/MAPK pathway.	Curcumin	0-8	mitogen-activated protein kinase 1	Mus musculus	122-125
34169637-6	2021	Curcumin could also inhibit the expression of cyclin D1/CDK4/6 and anti-apoptotic protein Bcl-2/Bcl-XL induced by NE, and induced cell cycle changes and increased apoptosis.	Curcumin	0-8	cyclin-dependent kinase 4	Mus musculus	56-62
34169637-6	2021	Curcumin could also inhibit the expression of cyclin D1/CDK4/6 and anti-apoptotic protein Bcl-2/Bcl-XL induced by NE, and induced cell cycle changes and increased apoptosis.	Curcumin	0-8	B cell leukemia/lymphoma 2	Mus musculus	90-95
34109436-0	2021	Curcumin induces apoptosis by inhibiting BCAT1 expression and mTOR signaling in cytarabine-resistant myeloid leukemia cells.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	62-66
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Curcumin	44-52	amyloid beta precursor protein	Homo sapiens	268-280
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Curcumin	44-52	amyloid beta precursor protein	Homo sapiens	282-287
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Curcumin	54-58	amyloid beta precursor protein	Homo sapiens	268-280
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Curcumin	54-58	amyloid beta precursor protein	Homo sapiens	282-287
34109436-7	2021	The present study aimed to investigate whether curcumin induces apoptosis by regulating BCAT1 expression and mTOR signaling in cytarabine-resistant myeloid leukemia cells.	Curcumin	47-55	mechanistic target of rapamycin kinase	Homo sapiens	109-113
34109436-12	2021	The present results indicated that curcumin may induce apoptosis by inhibiting the BCAT1 and mTOR pathways.	Curcumin	35-43	mechanistic target of rapamycin kinase	Homo sapiens	93-97
34360703-7	2021	Some (poly)phenolics such as caffeic acid, hydroxytyrosol, resveratrol, curcumin, nordihydroguaiaretic acid (NDGA), and quercetin have been reported to reduce the formation of 5-LOX eicosanoids in vitro.	Curcumin	72-80	arachidonate 5-lipoxygenase	Homo sapiens	176-181
34355287-5	2021	METHODS: The effect of curcumin and BDMC-A on transcription factors (NF-kappaB, p65, c-Jun, c-Fos, STAT3, 5, PPAR-gamma, beta-catenin, COX-2, MMP-9, VEGF, TIMP-2) involved in signal transduction cascade, invasion, and angiogenesis in Hep-2 cells were quantified using Western blotting and RT-PCR technique.	Curcumin	23-31	nuclear factor kappa B subunit 1	Homo sapiens	69-78
34146894-4	2021	To this end, we detected transcription factor 6 (ATF6), the key factor of regulating lipid metabolism along with other related molecules (CHOP and GPR78) and found that curcumin significantly impaired the gene synthesis of ATF6, while CSFV infection promoted ATF6 expression.	Curcumin	169-177	transcription factor A, mitochondrial	Homo sapiens	25-47
34146894-4	2021	To this end, we detected transcription factor 6 (ATF6), the key factor of regulating lipid metabolism along with other related molecules (CHOP and GPR78) and found that curcumin significantly impaired the gene synthesis of ATF6, while CSFV infection promoted ATF6 expression.	Curcumin	169-177	DNA damage inducible transcript 3	Homo sapiens	138-142
34328379-0	2021	A novel vision into the binding behavior of curcumin with human serum albumin-holo transferrin complex: molecular dynamic simulation and multi-spectroscopic perspectives.	Curcumin	44-52	albumin	Homo sapiens	64-77
34328379-0	2021	A novel vision into the binding behavior of curcumin with human serum albumin-holo transferrin complex: molecular dynamic simulation and multi-spectroscopic perspectives.	Curcumin	44-52	transferrin	Homo sapiens	83-94
34328379-1	2021	In this work, we investigated the simultaneous binding of curcumin (CUR) to human serum albumin (HSA) and human-holo transferrin (HTF) in the roles of binary and ternary systems.	Curcumin	58-66	albumin	Homo sapiens	82-95
34584659-9	2021	Within analysis indicated a significant decrease in CRP, LDH, MDA levels, and a significant increase in VO2 max in the curcumin group after an intervention (P < 0.05).	Curcumin	119-127	C-reactive protein	Homo sapiens	52-55
34584659-10	2021	There were significant decreases in CRP (P = 0.002), LDH (P = 0.041), and MDA (P = 0.005), no significant increase in TAC, and significant increase in VO2 max (P = 0.0001) levels in the curcumin group compared with placebo group.	Curcumin	186-194	C-reactive protein	Homo sapiens	36-39
34584659-12	2021	Conclusions: Our findings indicated that 8-week curcumin administration could significantly improve CRP, LDH, MDA, and VO2 max.	Curcumin	48-56	C-reactive protein	Homo sapiens	100-103
34361702-2	2021	Over the last decade, many innovative curcumin-based compounds have been designed and synthesized, searching for new derivatives having anti-amyloidogenic, inhibitory of tau formation, as well as anti-neuroinflammation, antioxidative, and AChE inhibitory activities.	Curcumin	38-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	239-243
34355287-5	2021	METHODS: The effect of curcumin and BDMC-A on transcription factors (NF-kappaB, p65, c-Jun, c-Fos, STAT3, 5, PPAR-gamma, beta-catenin, COX-2, MMP-9, VEGF, TIMP-2) involved in signal transduction cascade, invasion, and angiogenesis in Hep-2 cells were quantified using Western blotting and RT-PCR technique.	Curcumin	23-31	signal transducer and activator of transcription 3	Homo sapiens	99-107
34355287-5	2021	METHODS: The effect of curcumin and BDMC-A on transcription factors (NF-kappaB, p65, c-Jun, c-Fos, STAT3, 5, PPAR-gamma, beta-catenin, COX-2, MMP-9, VEGF, TIMP-2) involved in signal transduction cascade, invasion, and angiogenesis in Hep-2 cells were quantified using Western blotting and RT-PCR technique.	Curcumin	23-31	peroxisome proliferator activated receptor gamma	Homo sapiens	109-119
34355287-5	2021	METHODS: The effect of curcumin and BDMC-A on transcription factors (NF-kappaB, p65, c-Jun, c-Fos, STAT3, 5, PPAR-gamma, beta-catenin, COX-2, MMP-9, VEGF, TIMP-2) involved in signal transduction cascade, invasion, and angiogenesis in Hep-2 cells were quantified using Western blotting and RT-PCR technique.	Curcumin	23-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140
34355287-5	2021	METHODS: The effect of curcumin and BDMC-A on transcription factors (NF-kappaB, p65, c-Jun, c-Fos, STAT3, 5, PPAR-gamma, beta-catenin, COX-2, MMP-9, VEGF, TIMP-2) involved in signal transduction cascade, invasion, and angiogenesis in Hep-2 cells were quantified using Western blotting and RT-PCR technique.	Curcumin	23-31	vascular endothelial growth factor A	Homo sapiens	149-153
34337082-0	2021	RNA-seq and In Vitro Experiments Reveal the Protective Effect of Curcumin against 5-Fluorouracil-Induced Intestinal Mucositis via IL-6/STAT3 Signaling Pathway.	Curcumin	65-73	interleukin 6	Rattus norvegicus	130-134
34337082-7	2021	Further RNA-sequencing analysis and experiment validation found that curcumin displays its protective effect against 5-FU-induced IM in intestinal epithelial cells by the inhibition of IL-6/STAT3 signaling pathway.	Curcumin	69-77	interleukin 6	Rattus norvegicus	185-189
34305950-4	2021	We found that, in apolipoprotein E deficient mice, sc treatment with curcumin following the REMID strategy induced atheroprotection that was not consequence of its direct systemic lipid-modifying or antioxidant activity, but instead paralleled immunomodulatory effects, such as reduced proatherogenic IFNgamma/TNFalpha-producing cells and increased atheroprotective FOXP3+ Tregs and IL-10-producing dendritic and B cells.	Curcumin	69-77	tumor necrosis factor	Mus musculus	310-318
34299209-0	2021	A Galantamine-Curcumin Hybrid Decreases the Cytotoxicity of Amyloid-Beta Peptide on SH-SY5Y Cells.	Curcumin	14-22	amyloid beta precursor protein	Homo sapiens	60-72
34299209-7	2021	It was found that 4b protects cells in a similar mode as GAL, while compound 8 and CU potentiate the toxic effects of Abeta.	Curcumin	83-85	amyloid beta precursor protein	Homo sapiens	118-123
34305950-4	2021	We found that, in apolipoprotein E deficient mice, sc treatment with curcumin following the REMID strategy induced atheroprotection that was not consequence of its direct systemic lipid-modifying or antioxidant activity, but instead paralleled immunomodulatory effects, such as reduced proatherogenic IFNgamma/TNFalpha-producing cells and increased atheroprotective FOXP3+ Tregs and IL-10-producing dendritic and B cells.	Curcumin	69-77	apolipoprotein E	Mus musculus	18-34
34305950-4	2021	We found that, in apolipoprotein E deficient mice, sc treatment with curcumin following the REMID strategy induced atheroprotection that was not consequence of its direct systemic lipid-modifying or antioxidant activity, but instead paralleled immunomodulatory effects, such as reduced proatherogenic IFNgamma/TNFalpha-producing cells and increased atheroprotective FOXP3+ Tregs and IL-10-producing dendritic and B cells.	Curcumin	69-77	interferon gamma	Mus musculus	301-309
34298639-6	2021	The current review has highlighted the anticancer activity of curcumin in hormone-independent breast cancer via focusing on its impact on key signaling pathways including the PI3K/Akt/mTOR pathway, JAK/STAT pathway, MAPK pathway, NF-kB pathway, p53 pathway, and Wnt/beta-catenin, as well as apoptotic and cell cycle pathways.	Curcumin	62-70	AKT serine/threonine kinase 1	Homo sapiens	180-183
34298639-6	2021	The current review has highlighted the anticancer activity of curcumin in hormone-independent breast cancer via focusing on its impact on key signaling pathways including the PI3K/Akt/mTOR pathway, JAK/STAT pathway, MAPK pathway, NF-kB pathway, p53 pathway, and Wnt/beta-catenin, as well as apoptotic and cell cycle pathways.	Curcumin	62-70	mechanistic target of rapamycin kinase	Homo sapiens	184-188
34298639-6	2021	The current review has highlighted the anticancer activity of curcumin in hormone-independent breast cancer via focusing on its impact on key signaling pathways including the PI3K/Akt/mTOR pathway, JAK/STAT pathway, MAPK pathway, NF-kB pathway, p53 pathway, and Wnt/beta-catenin, as well as apoptotic and cell cycle pathways.	Curcumin	62-70	tumor protein p53	Homo sapiens	245-248
34305950-4	2021	We found that, in apolipoprotein E deficient mice, sc treatment with curcumin following the REMID strategy induced atheroprotection that was not consequence of its direct systemic lipid-modifying or antioxidant activity, but instead paralleled immunomodulatory effects, such as reduced proatherogenic IFNgamma/TNFalpha-producing cells and increased atheroprotective FOXP3+ Tregs and IL-10-producing dendritic and B cells.	Curcumin	69-77	interleukin 10	Mus musculus	383-388
34305950-6	2021	The essential role of curcumin-induced IL-10 for neuroprotection was confirmed by the complete abrogation of the clinical effects in IL-10-deficient mice.	Curcumin	22-30	interleukin 10	Mus musculus	39-44
34305950-6	2021	The essential role of curcumin-induced IL-10 for neuroprotection was confirmed by the complete abrogation of the clinical effects in IL-10-deficient mice.	Curcumin	22-30	interleukin 10	Mus musculus	133-138
34229599-21	2021	U0126 (an ERK inhibitor), curcumin (an AP-1 inhibitor) or c-Jun siRNA downregulated hypoxia-induced Pref-1 expression.	Curcumin	26-34	delta like non-canonical Notch ligand 1	Homo sapiens	100-106
34565029-3	2021	Western blot analyses were performed to detect protein levels of apoptosis-associated genes, JAK2 and STAT3 in TPC-1 and SW1736 cells treated with different doses of curcumin.	Curcumin	166-174	signal transducer and activator of transcription 3	Homo sapiens	102-107
34565029-3	2021	Western blot analyses were performed to detect protein levels of apoptosis-associated genes, JAK2 and STAT3 in TPC-1 and SW1736 cells treated with different doses of curcumin.	Curcumin	166-174	two pore segment channel 1	Homo sapiens	111-116
34565029-4	2021	RESULTS: Curcumin treatment dose-dependently reduced viability, clonality and metastatic ability in TPC-1 and SW1736 cells.	Curcumin	9-17	two pore segment channel 1	Homo sapiens	100-105
34565029-0	2021	Curcumin inhibits proliferation and invasion of papillary thyroid carcinoma cells by inhibiting the JAK2 / STAT3 pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	107-112
34565029-1	2021	PURPOSE: The purpose of this study was to analyze the function of curcumin to suppress the proliferative and invasive abilities of papillary thyroid carcinoma (PTC) through inhibiting the JAK2/STAT3 pathway.	Curcumin	66-74	signal transducer and activator of transcription 3	Homo sapiens	193-198
34565029-2	2021	METHODS: After treatment of different doses of curcumin in TPC-1 and SW1736 cells, changes in viability, clonality, cell cycle, apoptosis, wound healing and invasion were determined.	Curcumin	47-55	two pore segment channel 1	Homo sapiens	59-64
34565029-6	2021	Curcumin treatment downregulated Bcl-2 and upregulated Bax in PTC cells.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	33-38
34565029-6	2021	Curcumin treatment downregulated Bcl-2 and upregulated Bax in PTC cells.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	55-58
34565029-7	2021	In addition, curcumin treatment downregulated p-JAK2 and p-STAT3 in TPC-1 and SW1736 cells.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	59-64
34565029-7	2021	In addition, curcumin treatment downregulated p-JAK2 and p-STAT3 in TPC-1 and SW1736 cells.	Curcumin	13-21	two pore segment channel 1	Homo sapiens	68-73
34565029-8	2021	CONCLUSIONS: Curcumin treatment blocks PTC cells to proliferate and invade via inhibiting the JAK2/STAT3 pathway.	Curcumin	13-21	signal transducer and activator of transcription 3	Homo sapiens	99-104
34192476-12	2021	On retrospection of the synergistic effect of upregulated c-MYC and BCL-2 in cancer, we have also reported a new pathway (MYC-E2F-1-BCL-2-axis) through which Curcumin trigger apoptosis in cancer cells.Communicated by Ramaswamy H. Sarma.	Curcumin	158-166	BCL2 apoptosis regulator	Homo sapiens	68-73
34234415-1	2021	Purpose: A novel folate receptor-targeted beta-cyclodextrin (beta-CD) drug delivery vehicle was constructed to improve the bioavailability, biosafety, and drug loading capacity of curcumin.	Curcumin	180-188	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	61-68
34192476-12	2021	On retrospection of the synergistic effect of upregulated c-MYC and BCL-2 in cancer, we have also reported a new pathway (MYC-E2F-1-BCL-2-axis) through which Curcumin trigger apoptosis in cancer cells.Communicated by Ramaswamy H. Sarma.	Curcumin	158-166	BCL2 apoptosis regulator	Homo sapiens	132-137
34202657-9	2021	Nano-curcumin supplementation also showed favorable anti-inflammatory effects by decreasing C-reactive protein (CRP) (WMD: -1.29 mg/L; 95% CI: -2.15 to -0.44; p = 0.003) and interleukin-6 (IL-6) (WMD: -2.78 mg/dL; 95% CI: -3.76 to -1.79; p< 0.001).	Curcumin	5-13	C-reactive protein	Homo sapiens	92-110
34201974-0	2021	A Novel Curcumin-Mycophenolic Acid Conjugate Inhibited Hyperproliferation of Tumor Necrosis Factor-Alpha-Induced Human Keratinocyte Cells.	Curcumin	8-16	tumor necrosis factor	Homo sapiens	77-104
34202024-0	2021	Curcumin Suppresses TGF-beta1-Induced Myofibroblast Differentiation and Attenuates Angiogenic Activity of Orbital Fibroblasts.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	20-29
34202024-4	2021	This study aims to investigate the effects of curcumin on TGF-beta1-induced myofibroblast differentiation and on the pro-angiogenic activities of orbital fibroblasts.	Curcumin	46-54	transforming growth factor beta 1	Homo sapiens	58-67
34202024-5	2021	Orbital fibroblasts from one healthy donor and three patients with GO were collected for primary cell culture and subjected to myofibroblast differentiation under the administration of 1 or 5 ng/mL TGF-beta1 for 24 h. The effects of curcumin on TGF-beta1-induced orbital fibroblasts were assessed by measuring the cellular viability and detecting the expression of myofibroblast differentiation markers, including connective tissue growth factor (CTGF) and alpha-smooth muscle actin (alpha-SMA).	Curcumin	233-241	actin alpha 1, skeletal muscle	Homo sapiens	484-493
34202024-7	2021	Treatment of orbital fibroblasts with curcumin inhibited the TGF-beta1 signaling pathway and attenuated the expression of CTGF and alpha-SMA induced by TGF-beta1.	Curcumin	38-46	transforming growth factor beta 1	Homo sapiens	61-70
34202657-9	2021	Nano-curcumin supplementation also showed favorable anti-inflammatory effects by decreasing C-reactive protein (CRP) (WMD: -1.29 mg/L; 95% CI: -2.15 to -0.44; p = 0.003) and interleukin-6 (IL-6) (WMD: -2.78 mg/dL; 95% CI: -3.76 to -1.79; p< 0.001).	Curcumin	5-13	C-reactive protein	Homo sapiens	112-115
34202024-7	2021	Treatment of orbital fibroblasts with curcumin inhibited the TGF-beta1 signaling pathway and attenuated the expression of CTGF and alpha-SMA induced by TGF-beta1.	Curcumin	38-46	actin alpha 1, skeletal muscle	Homo sapiens	131-140
34202024-7	2021	Treatment of orbital fibroblasts with curcumin inhibited the TGF-beta1 signaling pathway and attenuated the expression of CTGF and alpha-SMA induced by TGF-beta1.	Curcumin	38-46	transforming growth factor beta 1	Homo sapiens	152-161
34202657-9	2021	Nano-curcumin supplementation also showed favorable anti-inflammatory effects by decreasing C-reactive protein (CRP) (WMD: -1.29 mg/L; 95% CI: -2.15 to -0.44; p = 0.003) and interleukin-6 (IL-6) (WMD: -2.78 mg/dL; 95% CI: -3.76 to -1.79; p< 0.001).	Curcumin	5-13	interleukin 6	Homo sapiens	174-187
34202024-8	2021	Curcumin, at the concentration of 5 mug/mL, suppressed 5 ng/mL TGF-beta1-induced pro-angiogenic activities of orbital fibroblast-conditioned EA hy926 and HMEC-1 endothelial cells.	Curcumin	0-8	transforming growth factor beta 1	Homo sapiens	63-72
34202024-9	2021	Our findings suggest that curcumin reduces the TGF-beta1-induced myofibroblast differentiation and pro-angiogenic activity in orbital fibroblasts.	Curcumin	26-34	transforming growth factor beta 1	Homo sapiens	47-56
34202657-9	2021	Nano-curcumin supplementation also showed favorable anti-inflammatory effects by decreasing C-reactive protein (CRP) (WMD: -1.29 mg/L; 95% CI: -2.15 to -0.44; p = 0.003) and interleukin-6 (IL-6) (WMD: -2.78 mg/dL; 95% CI: -3.76 to -1.79; p< 0.001).	Curcumin	5-13	interleukin 6	Homo sapiens	189-193
34248973-5	2021	The curcumin analog and antitumor agent, GO-Y030, prevented the TGF-beta-induced generation of Tregs by preventing p300 from accelerating NF-kappaB-induced Foxp3 expression.	Curcumin	4-12	nuclear factor kappa B subunit 1	Homo sapiens	138-147
34257809-0	2021	The Combination Treatment of Curcumin and Probucol Protects Chondrocytes from TNF-alpha Induced Inflammation by Enhancing Autophagy and Reducing Apoptosis via the PI3K-Akt-mTOR Pathway.	Curcumin	29-37	tumor necrosis factor	Homo sapiens	78-87
34257809-0	2021	The Combination Treatment of Curcumin and Probucol Protects Chondrocytes from TNF-alpha Induced Inflammation by Enhancing Autophagy and Reducing Apoptosis via the PI3K-Akt-mTOR Pathway.	Curcumin	29-37	AKT serine/threonine kinase 1	Homo sapiens	168-171
34257809-0	2021	The Combination Treatment of Curcumin and Probucol Protects Chondrocytes from TNF-alpha Induced Inflammation by Enhancing Autophagy and Reducing Apoptosis via the PI3K-Akt-mTOR Pathway.	Curcumin	29-37	mechanistic target of rapamycin kinase	Homo sapiens	172-176
34257809-17	2021	Besides, in vivo studies also showed that when applied in combination, curcumin and probucol could block the PI3K-AKT-mTOR signaling pathway; promote COL-II expression; suppress P62, MMP-3, and MMP-13 expression; and inhibit TNF-alpha-stimulated cartilage degradation.	Curcumin	71-79	AKT serine/threonine kinase 1	Homo sapiens	114-117
34257809-17	2021	Besides, in vivo studies also showed that when applied in combination, curcumin and probucol could block the PI3K-AKT-mTOR signaling pathway; promote COL-II expression; suppress P62, MMP-3, and MMP-13 expression; and inhibit TNF-alpha-stimulated cartilage degradation.	Curcumin	71-79	mechanistic target of rapamycin kinase	Homo sapiens	118-122
34257809-17	2021	Besides, in vivo studies also showed that when applied in combination, curcumin and probucol could block the PI3K-AKT-mTOR signaling pathway; promote COL-II expression; suppress P62, MMP-3, and MMP-13 expression; and inhibit TNF-alpha-stimulated cartilage degradation.	Curcumin	71-79	matrix metallopeptidase 3	Homo sapiens	183-188
34257809-17	2021	Besides, in vivo studies also showed that when applied in combination, curcumin and probucol could block the PI3K-AKT-mTOR signaling pathway; promote COL-II expression; suppress P62, MMP-3, and MMP-13 expression; and inhibit TNF-alpha-stimulated cartilage degradation.	Curcumin	71-79	matrix metallopeptidase 13	Homo sapiens	194-200
34257809-17	2021	Besides, in vivo studies also showed that when applied in combination, curcumin and probucol could block the PI3K-AKT-mTOR signaling pathway; promote COL-II expression; suppress P62, MMP-3, and MMP-13 expression; and inhibit TNF-alpha-stimulated cartilage degradation.	Curcumin	71-79	tumor necrosis factor	Homo sapiens	225-234
34257809-20	2021	A combined treatment of curcumin and probucol could be used to protect chondrocytes from inflammatory cytokine stress via inhibition of the autophagy-related PI3K/Akt/mTOR pathway both in vitro and in vivo, which might be of potential pharmaceutical value for OA prevention and therapy.	Curcumin	24-32	AKT serine/threonine kinase 1	Homo sapiens	163-166
34257809-20	2021	A combined treatment of curcumin and probucol could be used to protect chondrocytes from inflammatory cytokine stress via inhibition of the autophagy-related PI3K/Akt/mTOR pathway both in vitro and in vivo, which might be of potential pharmaceutical value for OA prevention and therapy.	Curcumin	24-32	mechanistic target of rapamycin kinase	Homo sapiens	167-171
34207376-0	2021	Single-Oocyte Gene Expression Suggests That Curcumin Can Protect the Ovarian Reserve by Regulating the PTEN-AKT-FOXO3a Pathway.	Curcumin	44-52	AKT serine/threonine kinase 1	Homo sapiens	108-111
34207376-0	2021	Single-Oocyte Gene Expression Suggests That Curcumin Can Protect the Ovarian Reserve by Regulating the PTEN-AKT-FOXO3a Pathway.	Curcumin	44-52	forkhead box O3	Homo sapiens	112-118
34207376-5	2021	Long-term treatment with 100 mg/kg curcumin improved the ovarian reserve indicators of AMH, FSH, and estradiol in aging mice.	Curcumin	35-43	follicle stimulating hormone beta	Mus musculus	92-95
34207376-6	2021	Mechanistic studies show that curcumin can affect the translocation of FOXO3, thereby inhibiting the PTEN-AKT-FOXO3a pathway and protecting primordial follicles from overactivation.	Curcumin	30-38	forkhead box O3	Homo sapiens	71-76
34207376-6	2021	Mechanistic studies show that curcumin can affect the translocation of FOXO3, thereby inhibiting the PTEN-AKT-FOXO3a pathway and protecting primordial follicles from overactivation.	Curcumin	30-38	AKT serine/threonine kinase 1	Homo sapiens	106-109
34207376-6	2021	Mechanistic studies show that curcumin can affect the translocation of FOXO3, thereby inhibiting the PTEN-AKT-FOXO3a pathway and protecting primordial follicles from overactivation.	Curcumin	30-38	forkhead box O3	Homo sapiens	110-116
34138966-7	2021	Our study also demonstrates that brazilin and theaflavin-3,3"-digallate, and to a still greater extent, curcumin, decrease the activity of transmembrane serine protease 2 both in cell-free and cell-based assays.	Curcumin	104-112	transmembrane serine protease 2	Homo sapiens	139-170
34141179-0	2021	Curcumin nicotinate suppresses abdominal aortic aneurysm pyroptosis via lncRNA PVT1/miR-26a/KLF4 axis through regulating the PI3K/AKT signaling pathway.	Curcumin	0-8	Kruppel-like factor 4 (gut)	Mus musculus	92-96
34195018-16	2021	The expression of apoptosis regulatory genes assessed by PCR revealed an upregulation of p53 by ME, accompanied by downregulation of Bcl-2 and high expression of Bax after treatment with curcumin.	Curcumin	187-195	tumor protein p53	Homo sapiens	89-92
34195018-16	2021	The expression of apoptosis regulatory genes assessed by PCR revealed an upregulation of p53 by ME, accompanied by downregulation of Bcl-2 and high expression of Bax after treatment with curcumin.	Curcumin	187-195	BCL2 apoptosis regulator	Homo sapiens	133-138
34195018-16	2021	The expression of apoptosis regulatory genes assessed by PCR revealed an upregulation of p53 by ME, accompanied by downregulation of Bcl-2 and high expression of Bax after treatment with curcumin.	Curcumin	187-195	BCL2 associated X, apoptosis regulator	Homo sapiens	162-165
34121550-0	2022	Catechin Metabolites along with Curcumin Inhibit Proliferation and Induce Apoptosis in Cervical Cancer Cells by Regulating VEGF Expression In-Vitro.	Curcumin	32-40	vascular endothelial growth factor A	Homo sapiens	123-127
34121550-8	2022	Results showed that catechin metabolites along with curcumin reduce the VEGF expression.	Curcumin	52-60	vascular endothelial growth factor A	Homo sapiens	72-76
34350255-0	2021	Curcumin exerts a protective effect on murine knee chondrocytes treated with IL-1beta through blocking the NF-kappaB/HIF-2alpha signaling pathway.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	107-116
34189277-0	2021	Curcumin pre-treatment may protect against mitochondrial damage in LRRK2-mutant Parkinson"s disease and healthy control fibroblasts.	Curcumin	0-8	leucine rich repeat kinase 2	Homo sapiens	67-72
34135585-7	2021	Significantly, the mechanism analysis revealed that curcumin and combretastatin A-4 phosphate could inhibit tumor angiogenesis and metastasis via down-regulation of VEGF and VEGFR2 expression, respectively, and that GA&Gal-Lip could improve antitumor effect by GA/Gal-mediated active-targeting delivery.	Curcumin	52-60	vascular endothelial growth factor A	Homo sapiens	165-169
34350255-9	2021	Results: Curcumin significantly inhibited the IL-1beta-induced reduction of cell viability, degradation of ECM, and the expression of SOX9, Col2alpha, and AGG (P<0.01).	Curcumin	9-17	collagen, type II, alpha 1	Mus musculus	140-149
34350255-10	2021	Western blotting, immunofluorescence and immunohistochemistry experiments demonstrated that curcumin dramatically inhibited the activation of NF-kappaB/HIF-2alpha in chondrocytes treated with IL-1beta (P<0.01).	Curcumin	92-100	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
34350255-12	2021	Conclusions: Curcumin may have the potential to inhibit OA development, partly through suppressing the activation of the NF-kappaB/HIF-2alpha pathway.	Curcumin	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	121-130
34103964-2	2021	This study aimed to determine whether curcumin exerts a chondroprotective effect by inhibiting apoptosis via upregulation of E2F1/PITX1 and activation of autophagy via the Akt/mTOR pathway by targeting microRNA-34a (miR-34a).	Curcumin	38-46	AKT serine/threonine kinase 1	Rattus norvegicus	172-175
34103964-12	2021	Greater numbers of apoptotic cells, lesser expression of p62, p-Akt, and p-mTOR, and greater expression of E2F1, PITX1, and LC3B were observed in the agomir-34a and high-dose curcumin-treated group than in agomir-34a and low-dose curcumin-treated group.	Curcumin	175-183	AKT serine/threonine kinase 1	Rattus norvegicus	64-67
34103964-13	2021	Conclusion: Curcumin"s chondroprotective effect was mediated by its suppression of miR-34a, apparently by reducing apoptosis, via upregulation of E2F1/PITX1, and by augmenting autophagy, likely via the Akt/mTOR pathway.	Curcumin	12-20	AKT serine/threonine kinase 1	Rattus norvegicus	202-205
34141179-0	2021	Curcumin nicotinate suppresses abdominal aortic aneurysm pyroptosis via lncRNA PVT1/miR-26a/KLF4 axis through regulating the PI3K/AKT signaling pathway.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	130-133
34141179-2	2021	Curcumin (Cur) is previously showed to attenuate AAA by inhibiting inflammatory response in ApoE -/- mice.	Curcumin	0-8	apolipoprotein E	Mus musculus	92-96
34141179-2	2021	Curcumin (Cur) is previously showed to attenuate AAA by inhibiting inflammatory response in ApoE -/- mice.	Curcumin	10-13	apolipoprotein E	Mus musculus	92-96
34122411-0	2021	Curcumin Blunts IL-6 Dependent Endothelial-to-Mesenchymal Transition to Alleviate Renal Allograft Fibrosis Through Autophagy Activation.	Curcumin	0-8	interleukin 6	Homo sapiens	16-20
34122411-9	2021	This is the first demonstration of the role of autophagy in renal allograft fibrosis; our findings indicate that curcumin can alleviate chronic renal allograft injury by suppressing IL-6-dependent EndMT via activation of autophagy.	Curcumin	113-121	interleukin 6	Homo sapiens	182-186
34095313-7	2021	Treatment of 3D spheroids with curcumin decreased cell viability, accompanied by an increase in mediators of apoptosis and necroptosis, including cleaved caspase-3 and cleaved PARP, phospho (p)-RIP3, and p-MLKL proteins.	Curcumin	31-39	caspase 3	Homo sapiens	154-163
34073773-0	2021	GO-Y078, a Curcumin Analog, Induces Both Apoptotic Pathways in Human Osteosarcoma Cells via Activation of JNK and p38 Signaling.	Curcumin	11-19	mitogen-activated protein kinase 8	Homo sapiens	106-109
34073773-0	2021	GO-Y078, a Curcumin Analog, Induces Both Apoptotic Pathways in Human Osteosarcoma Cells via Activation of JNK and p38 Signaling.	Curcumin	11-19	mitogen-activated protein kinase 1	Homo sapiens	114-117
34095313-7	2021	Treatment of 3D spheroids with curcumin decreased cell viability, accompanied by an increase in mediators of apoptosis and necroptosis, including cleaved caspase-3 and cleaved PARP, phospho (p)-RIP3, and p-MLKL proteins.	Curcumin	31-39	poly(ADP-ribose) polymerase 1	Homo sapiens	176-180
34095619-3	2021	By encapsulating nanotechnologically-modified curcumin (CNP) and epidermal growth factor (EGF) into the hydrogel, OHA-CMC/CNP/EGF exhibited extraordinary antioxidant, anti-inflammatory, and migration-promoting effects in vitro.	Curcumin	46-54	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	56-59
34134960-6	2021	The results of Western blotting showed that curcumin also concentration-dependently increased the cellular expressions of caspase-3, caspase-9 and Bax and lowered the expressions of Bcl-2, cyclin B1, CDK1 and beta-catenin along with the downstream proteins cyclin D1 and c-myc in the Wnt/beta-catenin signaling pathway (P < 0.05).	Curcumin	44-52	caspase 3	Homo sapiens	122-131
34134960-6	2021	The results of Western blotting showed that curcumin also concentration-dependently increased the cellular expressions of caspase-3, caspase-9 and Bax and lowered the expressions of Bcl-2, cyclin B1, CDK1 and beta-catenin along with the downstream proteins cyclin D1 and c-myc in the Wnt/beta-catenin signaling pathway (P < 0.05).	Curcumin	44-52	BCL2 associated X, apoptosis regulator	Homo sapiens	147-150
34134960-6	2021	The results of Western blotting showed that curcumin also concentration-dependently increased the cellular expressions of caspase-3, caspase-9 and Bax and lowered the expressions of Bcl-2, cyclin B1, CDK1 and beta-catenin along with the downstream proteins cyclin D1 and c-myc in the Wnt/beta-catenin signaling pathway (P < 0.05).	Curcumin	44-52	BCL2 apoptosis regulator	Homo sapiens	182-187
34065600-5	2021	Interestingly, curcumin at low concentration (5 microM) potentiated, and at high concentration (50 microM) inhibited ABT-737-induced platelet apoptosis, which was accompanied by inhibition of ABT-737-mediated thrombin generation.	Curcumin	15-23	coagulation factor II, thrombin	Homo sapiens	209-217
34065600-8	2021	Because curcumin inhibits P-glycoprotein (P-gp) in cancer cells and contributes to overcoming multidrug resistance, we showed that curcumin similarly inhibited platelet P-gp activity.	Curcumin	8-16	ATP binding cassette subfamily B member 1	Homo sapiens	26-40
34065600-8	2021	Because curcumin inhibits P-glycoprotein (P-gp) in cancer cells and contributes to overcoming multidrug resistance, we showed that curcumin similarly inhibited platelet P-gp activity.	Curcumin	8-16	ATP binding cassette subfamily B member 1	Homo sapiens	42-46
34065600-8	2021	Because curcumin inhibits P-glycoprotein (P-gp) in cancer cells and contributes to overcoming multidrug resistance, we showed that curcumin similarly inhibited platelet P-gp activity.	Curcumin	131-139	ATP binding cassette subfamily B member 1	Homo sapiens	26-40
34065600-8	2021	Because curcumin inhibits P-glycoprotein (P-gp) in cancer cells and contributes to overcoming multidrug resistance, we showed that curcumin similarly inhibited platelet P-gp activity.	Curcumin	131-139	ATP binding cassette subfamily B member 1	Homo sapiens	42-46
34065600-8	2021	Because curcumin inhibits P-glycoprotein (P-gp) in cancer cells and contributes to overcoming multidrug resistance, we showed that curcumin similarly inhibited platelet P-gp activity.	Curcumin	131-139	ATP binding cassette subfamily B member 1	Homo sapiens	169-173
34095619-3	2021	By encapsulating nanotechnologically-modified curcumin (CNP) and epidermal growth factor (EGF) into the hydrogel, OHA-CMC/CNP/EGF exhibited extraordinary antioxidant, anti-inflammatory, and migration-promoting effects in vitro.	Curcumin	46-54	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	122-125
34374241-1	2021	Objective: To study the alleviating effects of curcumin on splenic inflammation in overtraining rats by regulating toll-like receptor 4 (TLR4)-p38 mitogen-activated protein kinase (p38 MAPK)/nuclear factor-kappa B (NF-kappaB) signaling pathway.	Curcumin	47-55	toll-like receptor 4	Rattus norvegicus	115-135
34069133-7	2021	Curcumin, resveratrol, and gallic acid prevented PM2.5-induced migration via the ROS-dependent NF-kappaB signaling pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	95-104
34159091-5	2021	Results: The serum levels of UN, Cr, NF-kappaB, ALT, AST, amylase, CK, LDH, inflammatory factors TNF-alpha and IL-10, and markers of early diagnosis of SAKI (NGAL, CysC, KIM-1) were significantly lower in the curcumin group than those in the placebo group (P<0.05).	Curcumin	209-217	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	53-56
34068636-1	2021	The polyphenols curcumin (CU) and ferulic acid (FA) are able to inhibit the aggregation of amyloid-beta (Abeta) peptide with different strengths.	Curcumin	16-24	amyloid beta precursor protein	Homo sapiens	91-103
34068636-1	2021	The polyphenols curcumin (CU) and ferulic acid (FA) are able to inhibit the aggregation of amyloid-beta (Abeta) peptide with different strengths.	Curcumin	16-24	amyloid beta precursor protein	Homo sapiens	105-110
34068636-1	2021	The polyphenols curcumin (CU) and ferulic acid (FA) are able to inhibit the aggregation of amyloid-beta (Abeta) peptide with different strengths.	Curcumin	26-28	amyloid beta precursor protein	Homo sapiens	91-103
34068636-1	2021	The polyphenols curcumin (CU) and ferulic acid (FA) are able to inhibit the aggregation of amyloid-beta (Abeta) peptide with different strengths.	Curcumin	26-28	amyloid beta precursor protein	Homo sapiens	105-110
34068636-3	2021	In the present study, we examine the effects of CU and FA on the folding process of an Abeta monomer by 1 micros molecular dynamics (MD) simulations.	Curcumin	48-50	amyloid beta precursor protein	Homo sapiens	87-92
34068636-6	2021	CU makes more and longer-lived hydrogen bonds, hydrophobic, pi-pi, and cation-pi interactions with Abeta peptide than FA does, which is in a good agreement with the observed stronger inhibitory activity of CU on Abeta aggregation.	Curcumin	0-2	amyloid beta precursor protein	Homo sapiens	99-104
34068636-6	2021	CU makes more and longer-lived hydrogen bonds, hydrophobic, pi-pi, and cation-pi interactions with Abeta peptide than FA does, which is in a good agreement with the observed stronger inhibitory activity of CU on Abeta aggregation.	Curcumin	0-2	amyloid beta precursor protein	Homo sapiens	212-217
34068636-6	2021	CU makes more and longer-lived hydrogen bonds, hydrophobic, pi-pi, and cation-pi interactions with Abeta peptide than FA does, which is in a good agreement with the observed stronger inhibitory activity of CU on Abeta aggregation.	Curcumin	206-208	amyloid beta precursor protein	Homo sapiens	99-104
34068636-6	2021	CU makes more and longer-lived hydrogen bonds, hydrophobic, pi-pi, and cation-pi interactions with Abeta peptide than FA does, which is in a good agreement with the observed stronger inhibitory activity of CU on Abeta aggregation.	Curcumin	206-208	amyloid beta precursor protein	Homo sapiens	212-217
34159091-6	2021	In addition, serum levels of TLR9 and its downstream molecules MyD88, IRF5, and IRF7 in the curcumin group were significantly lower than those in the placebo group (P<0.05).	Curcumin	92-100	interferon regulatory factor 5	Rattus norvegicus	70-74
34159091-5	2021	Results: The serum levels of UN, Cr, NF-kappaB, ALT, AST, amylase, CK, LDH, inflammatory factors TNF-alpha and IL-10, and markers of early diagnosis of SAKI (NGAL, CysC, KIM-1) were significantly lower in the curcumin group than those in the placebo group (P<0.05).	Curcumin	209-217	tumor necrosis factor	Rattus norvegicus	97-106
34374241-1	2021	Objective: To study the alleviating effects of curcumin on splenic inflammation in overtraining rats by regulating toll-like receptor 4 (TLR4)-p38 mitogen-activated protein kinase (p38 MAPK)/nuclear factor-kappa B (NF-kappaB) signaling pathway.	Curcumin	47-55	toll-like receptor 4	Rattus norvegicus	137-141
34374241-12	2021	Curcumin supplementation during training can down-regulate expressions of TLR4-p38 MAPK/NF-kappaB signaling pathway-related proteins, thereby maintaining a dynamic equilibrium between pro-inflammatory/anti-inflammatory cytokines, protecting the spleen.	Curcumin	0-8	toll-like receptor 4	Rattus norvegicus	74-78
34981469-9	2021	The expression levels of all tested genes were altered in all treatment groups compared to the control, with that of WNT1, CTNNB1, TCF, MTOR, AKT1, BIRC5, and CCND1 showing the most robust changes in the combined curcumin/berberine/5-FU treatment.	Curcumin	213-221	Wnt family member 1	Homo sapiens	117-121
34981470-11	2021	It can be concluded that medicinal plants, and herbal bioactive compounds, particularly curcumin, anthocyanins, resveratrol, soy, walnut, and dihydromyricetin can be used as adjunct or complementary therapeutic agents to increase plasma adiponectin, which could potentially prevent and treat NCDs.	Curcumin	88-96	adiponectin, C1Q and collagen domain containing	Homo sapiens	237-248
34981469-9	2021	The expression levels of all tested genes were altered in all treatment groups compared to the control, with that of WNT1, CTNNB1, TCF, MTOR, AKT1, BIRC5, and CCND1 showing the most robust changes in the combined curcumin/berberine/5-FU treatment.	Curcumin	213-221	hepatocyte nuclear factor 4 alpha	Homo sapiens	131-134
34981477-0	2021	The Role of Chemokines in Cardiovascular Diseases and the Therapeutic Effect of Curcumin on CXCL8 and CCL2 as Pathological Chemokines in Atherosclerosis.	Curcumin	80-88	C-X-C motif chemokine ligand 8	Homo sapiens	92-97
34981469-9	2021	The expression levels of all tested genes were altered in all treatment groups compared to the control, with that of WNT1, CTNNB1, TCF, MTOR, AKT1, BIRC5, and CCND1 showing the most robust changes in the combined curcumin/berberine/5-FU treatment.	Curcumin	213-221	mechanistic target of rapamycin kinase	Homo sapiens	136-140
34981488-0	2021	Nanomicellar Curcumin Supplementation Improves the Clinical Manifestations of HAM/TSP Patients.	Curcumin	13-21	thrombospondin 1	Homo sapiens	82-85
34981488-9	2021	CONCLUSION: Results suggest that curcumin can safely improve the clinical symptoms of HAM/TSP patients but has no observable positive effects on the HTLV-1 proviral load, Tax, and HBZ expression.	Curcumin	33-41	thrombospondin 1	Homo sapiens	90-93
34981469-9	2021	The expression levels of all tested genes were altered in all treatment groups compared to the control, with that of WNT1, CTNNB1, TCF, MTOR, AKT1, BIRC5, and CCND1 showing the most robust changes in the combined curcumin/berberine/5-FU treatment.	Curcumin	213-221	AKT serine/threonine kinase 1	Homo sapiens	142-146
34331688-10	2021	However, further studies are required to determine the optimum conditions for these effects of curcumin, particularly regarding readouts of insulin resistance.	Curcumin	95-103	insulin	Homo sapiens	140-147
34331689-4	2021	Additionally, curcumin may regulate novel signaling molecules and enzymes involved in the pathophysiology of diabetes, including glucagon-like peptide-1, dipeptidyl peptidase-4, glucose transporters, alpha-glycosidase, alpha-amylase, and peroxisome proliferator-activated receptor gamma (PPARgamma).	Curcumin	14-22	glucagon	Homo sapiens	129-152
34331689-4	2021	Additionally, curcumin may regulate novel signaling molecules and enzymes involved in the pathophysiology of diabetes, including glucagon-like peptide-1, dipeptidyl peptidase-4, glucose transporters, alpha-glycosidase, alpha-amylase, and peroxisome proliferator-activated receptor gamma (PPARgamma).	Curcumin	14-22	peroxisome proliferator activated receptor gamma	Homo sapiens	238-286
34331689-4	2021	Additionally, curcumin may regulate novel signaling molecules and enzymes involved in the pathophysiology of diabetes, including glucagon-like peptide-1, dipeptidyl peptidase-4, glucose transporters, alpha-glycosidase, alpha-amylase, and peroxisome proliferator-activated receptor gamma (PPARgamma).	Curcumin	14-22	peroxisome proliferator activated receptor gamma	Homo sapiens	288-297
34331695-9	2021	Erythrocyte sedimentation rate (ESR) and circulating C-reactive protein (CRP) were assessed in six and five studies, respectively, out of which four studies reported significant reductions in these parameters in response to curcumin treatment.	Curcumin	224-232	C-reactive protein	Homo sapiens	53-71
34331695-9	2021	Erythrocyte sedimentation rate (ESR) and circulating C-reactive protein (CRP) were assessed in six and five studies, respectively, out of which four studies reported significant reductions in these parameters in response to curcumin treatment.	Curcumin	224-232	C-reactive protein	Homo sapiens	73-76
34109908-6	2021	The results of western blotting showed that curcumin down-regulated the expression of nucleotide-binding oligomerization domain-containing protein-, leucine-rich repeats-, and pyrin domain-containing protein 1 (NLRP1), cysteinyl aspartate-specific protease 1 (caspase-1), gasdermin D (GSDMD), IL-1beta, IL-6, TNF-alpha, and iNOS proteins in OGD and MCAO models.	Curcumin	44-52	interleukin 1 alpha	Rattus norvegicus	293-301
34109908-6	2021	The results of western blotting showed that curcumin down-regulated the expression of nucleotide-binding oligomerization domain-containing protein-, leucine-rich repeats-, and pyrin domain-containing protein 1 (NLRP1), cysteinyl aspartate-specific protease 1 (caspase-1), gasdermin D (GSDMD), IL-1beta, IL-6, TNF-alpha, and iNOS proteins in OGD and MCAO models.	Curcumin	44-52	interleukin 6	Rattus norvegicus	303-307
34109908-6	2021	The results of western blotting showed that curcumin down-regulated the expression of nucleotide-binding oligomerization domain-containing protein-, leucine-rich repeats-, and pyrin domain-containing protein 1 (NLRP1), cysteinyl aspartate-specific protease 1 (caspase-1), gasdermin D (GSDMD), IL-1beta, IL-6, TNF-alpha, and iNOS proteins in OGD and MCAO models.	Curcumin	44-52	gasdermin D	Rattus norvegicus	272-283
34109908-6	2021	The results of western blotting showed that curcumin down-regulated the expression of nucleotide-binding oligomerization domain-containing protein-, leucine-rich repeats-, and pyrin domain-containing protein 1 (NLRP1), cysteinyl aspartate-specific protease 1 (caspase-1), gasdermin D (GSDMD), IL-1beta, IL-6, TNF-alpha, and iNOS proteins in OGD and MCAO models.	Curcumin	44-52	tumor necrosis factor	Rattus norvegicus	309-318
34109908-6	2021	The results of western blotting showed that curcumin down-regulated the expression of nucleotide-binding oligomerization domain-containing protein-, leucine-rich repeats-, and pyrin domain-containing protein 1 (NLRP1), cysteinyl aspartate-specific protease 1 (caspase-1), gasdermin D (GSDMD), IL-1beta, IL-6, TNF-alpha, and iNOS proteins in OGD and MCAO models.	Curcumin	44-52	gasdermin D	Rattus norvegicus	285-290
34109908-6	2021	The results of western blotting showed that curcumin down-regulated the expression of nucleotide-binding oligomerization domain-containing protein-, leucine-rich repeats-, and pyrin domain-containing protein 1 (NLRP1), cysteinyl aspartate-specific protease 1 (caspase-1), gasdermin D (GSDMD), IL-1beta, IL-6, TNF-alpha, and iNOS proteins in OGD and MCAO models.	Curcumin	44-52	nitric oxide synthase 2	Rattus norvegicus	324-328
35490921-10	2022	Curcumin in mice fed the standard diet increased the expression of proteins related to oxidative phosphorylation, ribosomes, and PPAR pathways.	Curcumin	0-8	peroxisome proliferator activated receptor alpha	Mus musculus	129-133
34284543-8	2021	The western blot results showed that the phosphorylation levels of ERK, JNK, MAPK, NF-kB and Akt were up-regulated by curcumin.	Curcumin	118-126	Eph receptor B1	Rattus norvegicus	67-70
34284543-8	2021	The western blot results showed that the phosphorylation levels of ERK, JNK, MAPK, NF-kB and Akt were up-regulated by curcumin.	Curcumin	118-126	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Curcumin	169-177	interleukin 1 alpha	Rattus norvegicus	44-52
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Curcumin	169-177	interleukin 6	Rattus norvegicus	60-64
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Curcumin	169-177	tumor necrosis factor	Rattus norvegicus	66-74
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Curcumin	169-177	mast cell protease 1-like 1	Rattus norvegicus	76-80
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Curcumin	341-349	interleukin 6	Rattus norvegicus	60-64
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Curcumin	341-349	tumor necrosis factor	Rattus norvegicus	66-74
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Curcumin	341-349	mast cell protease 1-like 1	Rattus norvegicus	76-80
34914324-10	2021	Conclusions: Lycopene combined with quercetin and curcumin is more effective than any of the three drugs used alone in the treatment of CP/CPPS, which may be associated with its alleviation of inflammatory response and oxidative stress by interaction between the NF-kappaB, MAPKs and Nrf2 signaling pathways.	Curcumin	50-58	NFE2 like bZIP transcription factor 2	Rattus norvegicus	284-288
34148046-0	2021	Curcumin Affects Leptin-Induced Expression of Methionine Adenosyltransferase 2A in Hepatic Stellate Cells by Inhibition of JNK Signaling.	Curcumin	0-8	methionine adenosyltransferase 2A	Homo sapiens	46-79
34148046-0	2021	Curcumin Affects Leptin-Induced Expression of Methionine Adenosyltransferase 2A in Hepatic Stellate Cells by Inhibition of JNK Signaling.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	123-126
34148046-9	2021	RESULTS: Curcumin reduced leptin-induced MAT2A expression.	Curcumin	9-17	methionine adenosyltransferase 2A	Homo sapiens	41-46
34148046-10	2021	JNK signaling contributed to leptin-induced increase in MAT2A level, which could be interrupted by curcumin treatment.	Curcumin	99-107	mitogen-activated protein kinase 8	Homo sapiens	0-3
34148046-10	2021	JNK signaling contributed to leptin-induced increase in MAT2A level, which could be interrupted by curcumin treatment.	Curcumin	99-107	methionine adenosyltransferase 2A	Homo sapiens	56-61
34148046-11	2021	Curcumin inhibited leptin-induced MAT2A promoter activity by influencing MAT2A promoter fragments between -2,847 bp and - 2,752 bp and between -2,752 bp and +49 bp.	Curcumin	0-8	methionine adenosyltransferase 2A	Homo sapiens	34-39
34148046-11	2021	Curcumin inhibited leptin-induced MAT2A promoter activity by influencing MAT2A promoter fragments between -2,847 bp and - 2,752 bp and between -2,752 bp and +49 bp.	Curcumin	0-8	methionine adenosyltransferase 2A	Homo sapiens	73-78
34148046-12	2021	The effect of curcumin on leptin-induced MAT2A expression paralleled the reductions in leptin-induced activated HSCs and liver fibrosis.	Curcumin	14-22	methionine adenosyltransferase 2A	Homo sapiens	41-46
35381537-6	2022	The sensor was successfully used for detection of curcumin in the ranges of 0.1-1 micromol L-1 and 1-30 micromol L-1, with acceptable detection limit (30 nmol L-1).	Curcumin	50-58	L1 cell adhesion molecule	Homo sapiens	91-100
35490921-9	2022	Curcumin prevented the change of expression of 13 proteins involved in oxidative phosphorylation (NDUFB8, NDUFB3, and ATP5L) in the cellular response to stress (PSMA5, HIST1H1D) and lipid metabolism (THRSP, DGAT1, ECI1, and ACOT13).	Curcumin	0-8	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G	Mus musculus	118-123
35526734-0	2022	Curcumin can improve Parkinson"s disease via activating BDNF/PI3k/Akt signaling pathways.	Curcumin	0-8	AKT serine/threonine kinase 1	Homo sapiens	66-69
35550528-0	2022	Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	78-82
35550528-11	2022	The chondroprotective effects of curcumin against OA are mediated by the AMPK/PINK1/Parkin pathway, and curcumin may serve as a potential novel drug for OA management.	Curcumin	33-41	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	73-77
35621145-0	2022	Curcumin inhibits the cancer-associated fibroblast-derived chemoresistance of gastric cancer through the suppression of the JAK/STAT3 signaling pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	128-133
35460707-12	2022	The therapeutic agents, most of them are phytochemicals such as resveratrol, berberine and curcumin, induce Nrf2 signaling in I/R injury alleviation.	Curcumin	91-99	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
35490494-14	2022	In addition, the active ingredients of herbs (resveratrol, thujaplicins, huperzine, and curcumin) could activate the activity of SIRT1 or SIRT3, thereby improving AKI.	Curcumin	88-96	sirtuin 3	Homo sapiens	138-143
35568344-0	2022	Curcumin attenuates LPS-induced sickness behavior and fever in rats by modulating Nrf2 activity.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	82-86
35568344-2	2022	The present study aimed to evaluate whether pretreatment with curcumin prevents the behavioral changes and fever induced by LPS through the modulation of nuclear factor-erythroid 2 related factor 2 (Nrf2).	Curcumin	62-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	154-197
35568344-2	2022	The present study aimed to evaluate whether pretreatment with curcumin prevents the behavioral changes and fever induced by LPS through the modulation of nuclear factor-erythroid 2 related factor 2 (Nrf2).	Curcumin	62-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	199-203
35568344-7	2022	Our data provide further evidence of curcumin"s ability to prevent LPS-induced sickness behavior and fever possibly by a mechanism related to the modulation of Nrf2 translocation.	Curcumin	37-45	NFE2 like bZIP transcription factor 2	Rattus norvegicus	160-164
35417810-0	2022	Computational design of a beta-wrapin"s N-terminal domain with canonical and non-canonical amino acid modifications mimicking curcumin"s proposed inhibitory function.	Curcumin	126-134	amyloid beta precursor protein	Homo sapiens	24-30
35621145-6	2022	The experimental models revealed that curcumin abrogated the CAF-mediated activation of the JAK/STAT3 signaling pathway in GC cells.	Curcumin	38-46	signal transducer and activator of transcription 3	Homo sapiens	96-101
35621145-9	2022	It is suggested that curcumin may be a suitable natural product which may be used to overcome chemoresistance by inhibiting the CAF-induced activation of the JAK/STAT3 signaling pathway in GC.	Curcumin	21-29	signal transducer and activator of transcription 3	Homo sapiens	162-167
35259661-5	2022	The present study focused on curcumin derivatives with reliable ADME profile and high molecular binding potency to different SARS-CoV-2 target enzymes (3CLPro, PLpro, NSP7/8/12, NSP7/8/12 +RNA, NSP15, NSP16, Spike, Spike+ACE).	Curcumin	29-37	angiotensin I converting enzyme	Homo sapiens	221-224
35526734-4	2022	Currently, relevant studies have confirmed that curcumin has an optimistic impact on neuroprotection via regulating BDNF and PI3k/Akt signaling pathways in neurodegenerative disease.	Curcumin	48-56	AKT serine/threonine kinase 1	Homo sapiens	130-133
35526734-5	2022	Here, we summarized the relationship between BDNF and PI3k/Akt signaling pathway, the main biological functions and neuroprotective effects of curcumin via activating BDNF and PI3k/Akt signaling pathways in Parkinson"s disease.	Curcumin	143-151	AKT serine/threonine kinase 1	Homo sapiens	59-62
35526734-5	2022	Here, we summarized the relationship between BDNF and PI3k/Akt signaling pathway, the main biological functions and neuroprotective effects of curcumin via activating BDNF and PI3k/Akt signaling pathways in Parkinson"s disease.	Curcumin	143-151	AKT serine/threonine kinase 1	Homo sapiens	181-184
35550920-2	2022	This work was aimed to develop more active Nrf2-dependent cytoprotectors than curcumin, a well-known dietary Nrf2 activator and cancer chemopreventive agent.	Curcumin	78-86	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
35346675-0	2022	In-silico and in-vitro investigation of STAT3-PIM1 heterodimeric complex: Its mechanism and inhibition by curcumin for cancer therapeutics.	Curcumin	106-114	signal transducer and activator of transcription 3	Homo sapiens	40-45
35550920-2	2022	This work was aimed to develop more active Nrf2-dependent cytoprotectors than curcumin, a well-known dietary Nrf2 activator and cancer chemopreventive agent.	Curcumin	78-86	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
35550920-6	2022	This work reveals the structural determinants and the activity mechanisms of CN-2F as an Nrf2-dependent cytoprotector, and gives useful information on how to design curcumin-inspired Nrf2 activators and cytoprotectors.	Curcumin	165-173	NFE2 like bZIP transcription factor 2	Homo sapiens	183-187
34999459-0	2022	Binding affinity of curcumin to bovine serum albumin enhanced by pulsed electric field pretreatment.	Curcumin	20-28	albumin	Homo sapiens	39-52
34999459-1	2022	The present study investigated the effect of pulsed electric field (PEF) pretreatment on the interaction between bovine serum albumin (BSA) and curcumin.	Curcumin	144-152	albumin	Homo sapiens	120-133
35612337-0	2022	Effects of Interval Training Intensity and Curcumin on expression of Endothelial Progenitor Cells mRNA and C Reactive Protein in Elderly Rats Heart.	Curcumin	43-51	C-reactive protein	Rattus norvegicus	107-125
35543146-8	2022	In addition, curcumin improved HUVEC function by restoring alphavbeta3 and reducing endothelin-1 expression.	Curcumin	13-21	endothelin 1	Homo sapiens	84-96
35487055-9	2022	Generally, both cell lines treated with the combination of Curcumin and As2O3 displayed decreased angiogenesis genes (VEGFA and VEGFC), apoptosis genes (BAX and Bcl2), and prostate cancer marker (KLK2), the zinc-finger protein (SNAIL); and an increase in expression (P < 0.05) of cell-cell adhesion molecule (E-cadherin) and tumor suppressor gene (P53) genes.	Curcumin	59-67	vascular endothelial growth factor A	Homo sapiens	118-123
35487055-9	2022	Generally, both cell lines treated with the combination of Curcumin and As2O3 displayed decreased angiogenesis genes (VEGFA and VEGFC), apoptosis genes (BAX and Bcl2), and prostate cancer marker (KLK2), the zinc-finger protein (SNAIL); and an increase in expression (P < 0.05) of cell-cell adhesion molecule (E-cadherin) and tumor suppressor gene (P53) genes.	Curcumin	59-67	vascular endothelial growth factor C	Homo sapiens	128-133
35487055-9	2022	Generally, both cell lines treated with the combination of Curcumin and As2O3 displayed decreased angiogenesis genes (VEGFA and VEGFC), apoptosis genes (BAX and Bcl2), and prostate cancer marker (KLK2), the zinc-finger protein (SNAIL); and an increase in expression (P < 0.05) of cell-cell adhesion molecule (E-cadherin) and tumor suppressor gene (P53) genes.	Curcumin	59-67	BCL2 associated X, apoptosis regulator	Homo sapiens	153-156
35487055-9	2022	Generally, both cell lines treated with the combination of Curcumin and As2O3 displayed decreased angiogenesis genes (VEGFA and VEGFC), apoptosis genes (BAX and Bcl2), and prostate cancer marker (KLK2), the zinc-finger protein (SNAIL); and an increase in expression (P < 0.05) of cell-cell adhesion molecule (E-cadherin) and tumor suppressor gene (P53) genes.	Curcumin	59-67	BCL2 apoptosis regulator	Homo sapiens	161-165
35487055-9	2022	Generally, both cell lines treated with the combination of Curcumin and As2O3 displayed decreased angiogenesis genes (VEGFA and VEGFC), apoptosis genes (BAX and Bcl2), and prostate cancer marker (KLK2), the zinc-finger protein (SNAIL); and an increase in expression (P < 0.05) of cell-cell adhesion molecule (E-cadherin) and tumor suppressor gene (P53) genes.	Curcumin	59-67	snail family transcriptional repressor 1	Homo sapiens	228-233
35487055-9	2022	Generally, both cell lines treated with the combination of Curcumin and As2O3 displayed decreased angiogenesis genes (VEGFA and VEGFC), apoptosis genes (BAX and Bcl2), and prostate cancer marker (KLK2), the zinc-finger protein (SNAIL); and an increase in expression (P < 0.05) of cell-cell adhesion molecule (E-cadherin) and tumor suppressor gene (P53) genes.	Curcumin	59-67	cadherin 1	Homo sapiens	309-319
35487055-9	2022	Generally, both cell lines treated with the combination of Curcumin and As2O3 displayed decreased angiogenesis genes (VEGFA and VEGFC), apoptosis genes (BAX and Bcl2), and prostate cancer marker (KLK2), the zinc-finger protein (SNAIL); and an increase in expression (P < 0.05) of cell-cell adhesion molecule (E-cadherin) and tumor suppressor gene (P53) genes.	Curcumin	59-67	tumor protein p53	Homo sapiens	348-351
35346675-0	2022	In-silico and in-vitro investigation of STAT3-PIM1 heterodimeric complex: Its mechanism and inhibition by curcumin for cancer therapeutics.	Curcumin	106-114	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	46-50
35346675-2	2022	Curcumin, a diarylheptanoid isolated from turmeric, effectively inhibits STAT3 signaling.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	73-78
35346675-3	2022	Selectively, we attempted to address interactions of STAT3, PIM1 and Curcumin for therapeutic intervention using in silico and in vitro experimental approaches.	Curcumin	69-77	signal transducer and activator of transcription 3	Homo sapiens	53-58
35346675-5	2022	Secondly, molecular dynamics simulations of heterodimeric STAT3-PIM1 complex with curcumin revealed binding of curcumin on PIM-1 interface of the complex through hydrogen bonds (Asp155) and hydrophobic interactions (Leu13, Phe18, Val21, etc.)	Curcumin	82-90	signal transducer and activator of transcription 3	Homo sapiens	58-63
35346675-5	2022	Secondly, molecular dynamics simulations of heterodimeric STAT3-PIM1 complex with curcumin revealed binding of curcumin on PIM-1 interface of the complex through hydrogen bonds (Asp155) and hydrophobic interactions (Leu13, Phe18, Val21, etc.)	Curcumin	82-90	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	64-68
35346675-5	2022	Secondly, molecular dynamics simulations of heterodimeric STAT3-PIM1 complex with curcumin revealed binding of curcumin on PIM-1 interface of the complex through hydrogen bonds (Asp155) and hydrophobic interactions (Leu13, Phe18, Val21, etc.)	Curcumin	82-90	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	123-128
35346675-5	2022	Secondly, molecular dynamics simulations of heterodimeric STAT3-PIM1 complex with curcumin revealed binding of curcumin on PIM-1 interface of the complex through hydrogen bonds (Asp155) and hydrophobic interactions (Leu13, Phe18, Val21, etc.)	Curcumin	82-90	interferon induced transmembrane protein 1	Homo sapiens	216-221
35346675-5	2022	Secondly, molecular dynamics simulations of heterodimeric STAT3-PIM1 complex with curcumin revealed binding of curcumin on PIM-1 interface of the complex through hydrogen bonds (Asp155) and hydrophobic interactions (Leu13, Phe18, Val21, etc.)	Curcumin	111-119	signal transducer and activator of transcription 3	Homo sapiens	58-63
35346675-5	2022	Secondly, molecular dynamics simulations of heterodimeric STAT3-PIM1 complex with curcumin revealed binding of curcumin on PIM-1 interface of the complex through hydrogen bonds (Asp155) and hydrophobic interactions (Leu13, Phe18, Val21, etc.)	Curcumin	111-119	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	64-68
35346675-5	2022	Secondly, molecular dynamics simulations of heterodimeric STAT3-PIM1 complex with curcumin revealed binding of curcumin on PIM-1 interface of the complex through hydrogen bonds (Asp155) and hydrophobic interactions (Leu13, Phe18, Val21, etc.)	Curcumin	111-119	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	123-128
35346675-5	2022	Secondly, molecular dynamics simulations of heterodimeric STAT3-PIM1 complex with curcumin revealed binding of curcumin on PIM-1 interface of the complex through hydrogen bonds (Asp155) and hydrophobic interactions (Leu13, Phe18, Val21, etc.)	Curcumin	111-119	interferon induced transmembrane protein 1	Homo sapiens	216-221
35346675-8	2022	Corroborating our results, expression levels of STAT3 and PIM1 decreased after curcumin treatment.	Curcumin	79-87	signal transducer and activator of transcription 3	Homo sapiens	48-53
35346675-8	2022	Corroborating our results, expression levels of STAT3 and PIM1 decreased after curcumin treatment.	Curcumin	79-87	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	58-62
35346675-9	2022	We observed that PIM1 interacts with STAT3 and these functional interactions are disrupted by curcumin.	Curcumin	94-102	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	17-21
35346675-9	2022	We observed that PIM1 interacts with STAT3 and these functional interactions are disrupted by curcumin.	Curcumin	94-102	signal transducer and activator of transcription 3	Homo sapiens	37-42
35346675-10	2022	The calculated band energy gap of heterodimeric STAT3-PIM1-Curcumin complex was of 9.621 kcal/mol.	Curcumin	59-67	signal transducer and activator of transcription 3	Homo sapiens	48-53
35346675-10	2022	The calculated band energy gap of heterodimeric STAT3-PIM1-Curcumin complex was of 9.621 kcal/mol.	Curcumin	59-67	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	54-58
35346675-11	2022	The present study revealed the role of curcumin in STAT3/PIM1 signaling and its binding affinity to the complex for design of advanced cancer therapeutics.	Curcumin	39-47	signal transducer and activator of transcription 3	Homo sapiens	51-56
35346675-11	2022	The present study revealed the role of curcumin in STAT3/PIM1 signaling and its binding affinity to the complex for design of advanced cancer therapeutics.	Curcumin	39-47	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	57-61
35617878-6	2022	Further, the HeLa cells were treated with the polymer encapsulated curcumin and Bcl2 siRNA (Pol-Cur-siRNA) for 24 h, which effectively suppressed the Bcl2 and simulated the autophagic pathway.	Curcumin	67-75	BCL2 apoptosis regulator	Homo sapiens	150-154
35629033-8	2022	In these studies, curcumin was able to reduce the expression of proinflammatory cytokines, lower the level of the C-reactive protein and improve clinical parameters.	Curcumin	18-26	C-reactive protein	Homo sapiens	114-132
35630552-0	2022	Curcumin Derivative C66 Suppresses Pancreatic Cancer Progression through the Inhibition of JNK-Mediated Inflammation.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	91-94
35549905-9	2022	Pretreatment with curcumin restored Prdx6 downregulation and inhibited NF-kappaB pathway activation by suppressing the nuclear translocation of P65, eventually reducing inflammation and oxidative stress damage in A549 cells.	Curcumin	18-26	nuclear factor kappa B subunit 1	Homo sapiens	71-80
35549905-10	2022	CONCLUSIONS: Prdx6 mediated the protective function of curcumin by inhibiting the activation of the NF-kappaB pathway in ALI in vitro.	Curcumin	55-63	nuclear factor kappa B subunit 1	Homo sapiens	100-109
35574627-7	2022	Meta-analysis showed that curcumin supplementation significantly reduced serum CK activity (WMD = -65.98 IU/L, 95% CI (-99.53 to -32.44)), muscle soreness (WMD = -0.56, 95% CI (-0.84 to -0.27)), and TNF-alpha concentration (WMD = -0.22 pg/ml, 95% CI (-0.33 to -0.10)).	Curcumin	26-34	tumor necrosis factor	Homo sapiens	199-208
35574627-8	2022	Also, curcumin supplementation elicited significant improvements in MVC (WMD = 3.10 nm, 95% CI (1.45-4.75)) and ROM (WMD = 6.49 , 95% CI (3.91-9.07)), although no significant changes in IL-6 and IL-8 levels were found.	Curcumin	6-14	interleukin 6	Homo sapiens	186-190
35574627-8	2022	Also, curcumin supplementation elicited significant improvements in MVC (WMD = 3.10 nm, 95% CI (1.45-4.75)) and ROM (WMD = 6.49 , 95% CI (3.91-9.07)), although no significant changes in IL-6 and IL-8 levels were found.	Curcumin	6-14	C-X-C motif chemokine ligand 8	Homo sapiens	195-199
35015114-3	2022	RESULTS: In experimental models, curcumin showed its pleiotropic effects in retinal diseases like diabetic retinopathy by increasing anti-oxidant enzymes, upregulating HO-1, nrf2 and reducing or inhibiting inflammatory mediators, growth factors and by inhibiting proliferation and migration of retinal endothelial cells in a dose-dependent manner in HRPC, HREC and ARPE-19 cells.	Curcumin	33-41	NFE2 like bZIP transcription factor 2	Homo sapiens	174-178
35532218-4	2022	Results demonstrate that a 3 h pretreatment of curcumin, followed by the treatment of gliadin protein for 24 h time period protected both the HCT-116 and HT-29 cells via: (i) decreasing the ROS/RNS, restoring the mitochondrial transmembrane potential; (ii) re-establishing the cellular antioxidant defense system (superoxide dismutase, catalase, and GSH); (iii) enhancing the functions of APE1 viz.	Curcumin	47-55	catalase	Homo sapiens	336-344
35179079-0	2022	Curcumin suppresses TGF-beta2-induced proliferation, migration, and invasion in lens epithelial cells by targeting KCNQ1OT1/miR-377-3p/COL1A2 axis in posterior capsule opacification.	Curcumin	0-8	collagen type I alpha 2 chain	Homo sapiens	135-141
35179079-15	2022	CONCLUSION: In conclusion, Curcumin suppressed TGF-beta2-induced malignant changes in lens epithelial cells by targeting KCNQ1OT1/miR-377-3p/COL1A2 axis.	Curcumin	27-35	collagen type I alpha 2 chain	Homo sapiens	141-147
35635460-7	2022	Here, the HBV entry inhibition assay used curcumin to inhibit HBV binding and transporting functions via NTCP.	Curcumin	42-50	solute carrier family 10 member 1	Homo sapiens	105-109
35585935-11	2022	Furthermore, curcumin repress the expression of SOX10, Notch1, and HES-1, and increase the expression of miR-222-3p.	Curcumin	13-21	notch receptor 1	Homo sapiens	55-61
35609329-8	2022	Curcumin inhibited the TNF-alpha-induced proliferation, migration, invasion of MH7A and RA-FLS cells and promoted cell apoptosis.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	23-32
35609329-9	2022	Administration with curcumin reversed the CIA-induced increase in arthritis scores, hind paw edema, and loss of appetite, while these effects were rescued by insulin-like growth factor 1, the upstream cytokine of PI3K/AKT.	Curcumin	20-28	thymoma viral proto-oncogene 1	Mus musculus	218-221
35609329-10	2022	Moreover, curcumin suppressed the inflammatory response by reducing TNF-alpha, IL-6, and IL-17 secretion in CIA-stimulated mice.	Curcumin	10-18	tumor necrosis factor	Mus musculus	68-77
35609329-10	2022	Moreover, curcumin suppressed the inflammatory response by reducing TNF-alpha, IL-6, and IL-17 secretion in CIA-stimulated mice.	Curcumin	10-18	interleukin 6	Mus musculus	79-83
35609329-11	2022	Curcumin has an excellent anti-RA effect in vivo and in vitro, which is exerted by inhibiting the expression of pro-inflammatory factors TNF-a, IL-6 and IL-17 and inhibiting the activation of PI3K/AKT signaling pathway.	Curcumin	0-8	tumor necrosis factor	Mus musculus	137-142
35609329-11	2022	Curcumin has an excellent anti-RA effect in vivo and in vitro, which is exerted by inhibiting the expression of pro-inflammatory factors TNF-a, IL-6 and IL-17 and inhibiting the activation of PI3K/AKT signaling pathway.	Curcumin	0-8	interleukin 6	Mus musculus	144-148
35609329-11	2022	Curcumin has an excellent anti-RA effect in vivo and in vitro, which is exerted by inhibiting the expression of pro-inflammatory factors TNF-a, IL-6 and IL-17 and inhibiting the activation of PI3K/AKT signaling pathway.	Curcumin	0-8	thymoma viral proto-oncogene 1	Mus musculus	197-200
35015114-4	2022	In age-related macular degeneration, curcumin acts by reducing ROS and inhibiting apoptosis inducing proteins and cellular inflammatory genes and upregulating HO-1, thioredoxin and NQO1.	Curcumin	37-45	NAD(P)H quinone dehydrogenase 1	Homo sapiens	181-185
35015114-7	2022	In retinal ischemia reperfusion injury, curcumin downregulates IL-17, IL-23, NFKB, STAT-3, MCP-1 and JNK.	Curcumin	40-48	signal transducer and activator of transcription 3	Homo sapiens	83-89
35015114-7	2022	In retinal ischemia reperfusion injury, curcumin downregulates IL-17, IL-23, NFKB, STAT-3, MCP-1 and JNK.	Curcumin	40-48	mitogen-activated protein kinase 8	Homo sapiens	101-104
35571134-0	2022	Curcumin Restrains Oxidative Stress of After Intracerebral Hemorrhage in Rat by Activating the Nrf2/HO-1 Pathway.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	95-99
35150143-6	2022	White blood cells, neutrophils, platelets, erythrocyte sedimentation rate (ESR), and the levels of interleukin-8 significantly decreased in the nano-curcumin group compared to the placebo after 10 days of intervention (p = .024, p = .045, p = .017, p = .041, and p = .004, respectively).	Curcumin	149-157	C-X-C motif chemokine ligand 8	Homo sapiens	99-112
35122926-4	2022	With the incubation of curcumin (1 muM), 6-OHDA-induced apoptosis was suppressed, increasing the autophagy markers (LC3-II/LC3-I, Beclin-1) and inhibiting phosphor-AKT/AKT, phosphor-mTOR/mTOR.	Curcumin	23-31	AKT serine/threonine kinase 1	Rattus norvegicus	164-167
35122926-4	2022	With the incubation of curcumin (1 muM), 6-OHDA-induced apoptosis was suppressed, increasing the autophagy markers (LC3-II/LC3-I, Beclin-1) and inhibiting phosphor-AKT/AKT, phosphor-mTOR/mTOR.	Curcumin	23-31	AKT serine/threonine kinase 1	Rattus norvegicus	168-171
35122926-5	2022	In vivo, curcumin (50 mg/kg) reduced the accumulation of a-synuclein and led to higher parkinsonian disability scores in 6-OHDA-lesioned PD rats, contributing to induction of autophagy through inhibiting AKT/mTOR signal pathway.	Curcumin	9-17	AKT serine/threonine kinase 1	Rattus norvegicus	204-207
35122926-7	2022	In conclusion, the present study demonstrated that curcumin repressed PC12 cell death in vitro and improved parkinsonian disability scores in vivo by inhibiting AKT/mTOR signaling pathway which mediated by autophagy, indicating a potential value of curcumin in the therapeutic intervention of Parkinson"s disease.	Curcumin	51-59	AKT serine/threonine kinase 1	Rattus norvegicus	161-164
35122926-7	2022	In conclusion, the present study demonstrated that curcumin repressed PC12 cell death in vitro and improved parkinsonian disability scores in vivo by inhibiting AKT/mTOR signaling pathway which mediated by autophagy, indicating a potential value of curcumin in the therapeutic intervention of Parkinson"s disease.	Curcumin	249-257	AKT serine/threonine kinase 1	Rattus norvegicus	161-164
35475714-13	2022	Conclusions: Our study showed some significant beneficial effects of curcumin supplementation on improving BW, BMI, and the levels of FPG, Hb1Ac, HOMA-IR, HDL-C and Hs-CRP in patients with MRDs.	Curcumin	69-77	C-reactive protein	Homo sapiens	168-171
35571134-9	2022	The results showed that curcumin significantly inhibited heme-induced oxidative stress, decreased intracellular ROS and MDA, and promoted Nrf2 and its downstream antioxidant gene (HO-1, NQO1, and Gpx4) expression.	Curcumin	24-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	138-142
35571134-9	2022	The results showed that curcumin significantly inhibited heme-induced oxidative stress, decreased intracellular ROS and MDA, and promoted Nrf2 and its downstream antioxidant gene (HO-1, NQO1, and Gpx4) expression.	Curcumin	24-32	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	186-190
35571134-10	2022	These results suggest that curcumin inhibits oxidative stress by activating the Nrf2/HO-1 pathway.	Curcumin	27-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	80-84
35571134-11	2022	Here, our results indicate that curcumin can promote the inhibition of oxidative stress in microglia by activating the Nrf2/HO-1 pathway and promoting neurological recovery after ICH, providing a new therapeutic target for clinical treatment of ICH.	Curcumin	32-40	NFE2 like bZIP transcription factor 2	Rattus norvegicus	119-123
35565795-5	2022	Gut microbiota analysis via 16S rRNA sequencing revealed that curcumin modulated gut microbiota, predominantly increasing microbiota associated with BA metabolism and short-chain fatty acid production, which subsequently up-regulated the expression of hepatic cholesterol 7-alpha hydroxylase and increased the synthesis of bile acids (p < 0.05).	Curcumin	62-70	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	260-291
35473535-15	2022	CONCLUSION: Aromatase inhibition by exemestane or curcumin had significantly inhibited the growth of lung cancer cell lines, synergized with cisplatin, raloxifene and celecoxib, suppressed lung cancer cell migratory potential, induced apoptosis, and reduced colony formation of lung cancer cells.	Curcumin	50-58	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	12-21
35314095-0	2022	Corrigendum to "Transferrin mediated solid lipid nanoparticles containing curcumin: Enhanced in-vitro anticancer activity by induction of apoptosis".	Curcumin	74-82	transferrin	Homo sapiens	16-27
35564180-6	2022	In an in silico molecular docking study of the gallium-curcumin complex in PDI, calnexin, HSP60, PDK, caspase 9, Akt1 and PTEN were found to be strong binding.	Curcumin	55-63	AKT serine/threonine kinase 1	Homo sapiens	113-117
35431006-5	2022	In addition, HN5 cells were also treated with curcumin to evaluate its effect on the caspase-8, -9, Bcl-2, Bax, and Stat3 genes expression.	Curcumin	46-54	BCL2 apoptosis regulator	Homo sapiens	100-105
35122786-0	2022	Curcumin activates the Nrf2 Pathway to alleviate AFB1-induced immunosuppression in the spleen of ducklings.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	23-27
35629293-0	2022	Curcumin Protects Diabetic Mice against Isoproterenol-Induced Myocardial Infarction by Modulating CB2 Cannabinoid Receptors.	Curcumin	0-8	cannabinoid receptor 2 (macrophage)	Mus musculus	98-101
35629293-1	2022	Molecular docking revealed curcumin as a potent CB2 cannabinoid receptor (CB2R) agonist.	Curcumin	27-35	cannabinoid receptor 2 (macrophage)	Mus musculus	48-51
35629293-1	2022	Molecular docking revealed curcumin as a potent CB2 cannabinoid receptor (CB2R) agonist.	Curcumin	27-35	cannabinoid receptor 2 (macrophage)	Mus musculus	74-78
35629293-10	2022	The data suggest the involvement of CB2R in the actions of curcumin such as in the prevention of myocardial stress and in the improvement of the normal status of the myocardial membrane associated with diabetes.	Curcumin	59-67	cannabinoid receptor 2 (macrophage)	Mus musculus	36-40
35559378-7	2022	RESULTS: Network pharmacology suggested that curcumin treated EM through the HIF signaling pathway, of which IL-6, HIF-1alpha, and VEGFA are key targets.	Curcumin	45-53	interleukin 6	Mus musculus	109-113
35457197-0	2022	Modulation of Amyloid beta-Induced Microglia Activation and Neuronal Cell Death by Curcumin and Analogues.	Curcumin	83-91	amyloid beta precursor protein	Homo sapiens	14-26
35431006-5	2022	In addition, HN5 cells were also treated with curcumin to evaluate its effect on the caspase-8, -9, Bcl-2, Bax, and Stat3 genes expression.	Curcumin	46-54	BCL2 associated X, apoptosis regulator	Homo sapiens	107-110
35431006-5	2022	In addition, HN5 cells were also treated with curcumin to evaluate its effect on the caspase-8, -9, Bcl-2, Bax, and Stat3 genes expression.	Curcumin	46-54	signal transducer and activator of transcription 3	Homo sapiens	116-121
35431006-7	2022	Curcumin treatment caused decreased expression of Bcl2, with simultaneous upregulation of the Bax/Bcl2 ratio.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	50-54
35431006-7	2022	Curcumin treatment caused decreased expression of Bcl2, with simultaneous upregulation of the Bax/Bcl2 ratio.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	94-97
35431006-7	2022	Curcumin treatment caused decreased expression of Bcl2, with simultaneous upregulation of the Bax/Bcl2 ratio.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	98-102
35431006-10	2022	The induction of the mitochondria-dependent apoptosis pathway of curcumin happened by the modulation in the expression of Bcl2 and Bax genes, resulting in the caspase-9 activation, also curcumin causes the decreasing the expression of the Stat3 in HN-5 cells.	Curcumin	65-73	BCL2 apoptosis regulator	Homo sapiens	122-126
35431006-10	2022	The induction of the mitochondria-dependent apoptosis pathway of curcumin happened by the modulation in the expression of Bcl2 and Bax genes, resulting in the caspase-9 activation, also curcumin causes the decreasing the expression of the Stat3 in HN-5 cells.	Curcumin	65-73	BCL2 associated X, apoptosis regulator	Homo sapiens	131-134
35431006-10	2022	The induction of the mitochondria-dependent apoptosis pathway of curcumin happened by the modulation in the expression of Bcl2 and Bax genes, resulting in the caspase-9 activation, also curcumin causes the decreasing the expression of the Stat3 in HN-5 cells.	Curcumin	65-73	signal transducer and activator of transcription 3	Homo sapiens	239-244
35431006-10	2022	The induction of the mitochondria-dependent apoptosis pathway of curcumin happened by the modulation in the expression of Bcl2 and Bax genes, resulting in the caspase-9 activation, also curcumin causes the decreasing the expression of the Stat3 in HN-5 cells.	Curcumin	186-194	BCL2 apoptosis regulator	Homo sapiens	122-126
35431006-10	2022	The induction of the mitochondria-dependent apoptosis pathway of curcumin happened by the modulation in the expression of Bcl2 and Bax genes, resulting in the caspase-9 activation, also curcumin causes the decreasing the expression of the Stat3 in HN-5 cells.	Curcumin	186-194	BCL2 associated X, apoptosis regulator	Homo sapiens	131-134
35431006-10	2022	The induction of the mitochondria-dependent apoptosis pathway of curcumin happened by the modulation in the expression of Bcl2 and Bax genes, resulting in the caspase-9 activation, also curcumin causes the decreasing the expression of the Stat3 in HN-5 cells.	Curcumin	186-194	signal transducer and activator of transcription 3	Homo sapiens	239-244
35431006-11	2022	CONCLUSIONS: In conclusion, curcumin showed marked anticancer effects in the HN-5 cell line by modulation of Stat-3; Bax/Bcl 2 expression in vitro.	Curcumin	28-36	signal transducer and activator of transcription 3	Homo sapiens	109-115
35431006-11	2022	CONCLUSIONS: In conclusion, curcumin showed marked anticancer effects in the HN-5 cell line by modulation of Stat-3; Bax/Bcl 2 expression in vitro.	Curcumin	28-36	BCL2 associated X, apoptosis regulator	Homo sapiens	117-120
35431006-11	2022	CONCLUSIONS: In conclusion, curcumin showed marked anticancer effects in the HN-5 cell line by modulation of Stat-3; Bax/Bcl 2 expression in vitro.	Curcumin	28-36	BCL2 apoptosis regulator	Homo sapiens	121-126
35458704-5	2022	Curcumin attenuated lipopolysaccharide (LPS)-induced proinflammatory IL-6 and TNF-alpha gene expression in primary cultured rat astrocytes.	Curcumin	0-8	interleukin 6	Rattus norvegicus	69-73
35458704-5	2022	Curcumin attenuated lipopolysaccharide (LPS)-induced proinflammatory IL-6 and TNF-alpha gene expression in primary cultured rat astrocytes.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	78-87
35547777-2	2022	Here, we present a new nanomedicine platform based on tyramine-bearing two dimethylphosphonate sodium salt (TBP)-modified amphiphilic phosphorus dendron (C11G3) nanomicelles encapsulated with antioxidant drug curcumin (Cur).	Curcumin	209-217	TATA box binding protein	Mus musculus	108-111
35450396-3	2022	To evaluate curcumin"s anti-inflammatory impact on synoviocytes in the RA model, a set of experiments was conducted on SW982 cells, stimulated by IL-1beta, IL-6, or TNF-alpha to emulate inflammation.	Curcumin	12-20	tumor necrosis factor	Homo sapiens	165-174
35450396-4	2022	During the research, the curcumin effect was evaluated by measuring cell survivability, expression of MMP1 gene, subcellular localization of P70S6K1 protein, and its phosphorylated form and amount of produced IL-6 and TNF-alpha.	Curcumin	25-33	interleukin 6	Homo sapiens	209-213
35450396-4	2022	During the research, the curcumin effect was evaluated by measuring cell survivability, expression of MMP1 gene, subcellular localization of P70S6K1 protein, and its phosphorylated form and amount of produced IL-6 and TNF-alpha.	Curcumin	25-33	tumor necrosis factor	Homo sapiens	218-227
35450396-5	2022	Results of conducted experiments presented a positive impact of curcumin on synoviocytes in the RA model, by reducing SW982 cells" survivability, decreasing levels of MMP1 gene expression and TNF-alpha protein production, which altogether confirm beneficial effects of the curcumin therapy in a RA in vitro model.	Curcumin	64-72	tumor necrosis factor	Homo sapiens	192-201
35458662-5	2022	The synthesized curcumin analog 1d (p < 0.001, n = 6), and 1c (p < 0.01, n = 6) showed promising results by decreasing retention time in EPM, significantly increasing % SAP in Y-maze, while significantly (p < 0.001) enhancing the % discrimination index (DI) and the time exploring the novel objects in NORT mice behavioral models.	Curcumin	16-24	SH2 domain containing 1A	Mus musculus	169-172
35453772-9	2022	CONCLUSIONS: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-alpha, INF, IL-6, and IL-10 1 h after the end of exercise.	Curcumin	13-21	interleukin 2	Homo sapiens	188-192
35547777-2	2022	Here, we present a new nanomedicine platform based on tyramine-bearing two dimethylphosphonate sodium salt (TBP)-modified amphiphilic phosphorus dendron (C11G3) nanomicelles encapsulated with antioxidant drug curcumin (Cur).	Curcumin	219-222	TATA box binding protein	Mus musculus	108-111
35453772-9	2022	CONCLUSIONS: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-alpha, INF, IL-6, and IL-10 1 h after the end of exercise.	Curcumin	13-21	tumor necrosis factor	Homo sapiens	194-203
35453772-9	2022	CONCLUSIONS: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-alpha, INF, IL-6, and IL-10 1 h after the end of exercise.	Curcumin	13-21	interleukin 6	Homo sapiens	210-214
35453603-2	2022	To this end, the cytotoxic potential of raloxifene and the synthetic curcumin derivative 2,6-bis (pyridin-4-ylmethylene)-cyclohexanone (RL91) was examined in AR-(PC3 and DU145) cells and AR+ (LnCaP) CRPC cells.	Curcumin	69-77	androgen receptor	Homo sapiens	158-160
35400349-8	2022	Targeting MAPK/ERK, PI3k/AKT, Wnt/beta-catenin, Notch, and MircoRNA by curcumin has been evaluated to improve outcomes in patients with osteosarcoma.	Curcumin	71-79	mitogen-activated protein kinase 1	Homo sapiens	15-18
35400349-8	2022	Targeting MAPK/ERK, PI3k/AKT, Wnt/beta-catenin, Notch, and MircoRNA by curcumin has been evaluated to improve outcomes in patients with osteosarcoma.	Curcumin	71-79	AKT serine/threonine kinase 1	Homo sapiens	25-28
35409397-6	2022	Mechanistically, RNA-seq reveals that curcumin activates ERK and mTOR cascades through upregulating growth factor pathways for metabolic reconfiguration toward glycolysis.	Curcumin	38-46	mitogen-activated protein kinase 1	Homo sapiens	57-60
35409397-6	2022	Mechanistically, RNA-seq reveals that curcumin activates ERK and mTOR cascades through upregulating growth factor pathways for metabolic reconfiguration toward glycolysis.	Curcumin	38-46	mechanistic target of rapamycin kinase	Homo sapiens	65-69
35453603-2	2022	To this end, the cytotoxic potential of raloxifene and the synthetic curcumin derivative 2,6-bis (pyridin-4-ylmethylene)-cyclohexanone (RL91) was examined in AR-(PC3 and DU145) cells and AR+ (LnCaP) CRPC cells.	Curcumin	69-77	androgen receptor	Homo sapiens	187-189
34994998-0	2022	Curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib-resistant melanoma cells by downregulating the EGFR signaling pathway.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	124-128
35473503-0	2022	Curcumin relieved the rheumatoid arthritis progression via modulating the linc00052/miR-126-5p/PIAS2 axis.	Curcumin	0-8	protein inhibitor of activated STAT 2	Homo sapiens	95-100
35473503-12	2022	Curcumin inhibited the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	45-95
35473503-12	2022	Curcumin inhibited the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Homo sapiens	97-102
35473503-14	2022	These results reveal that curcumin protects against RA by regulating the inc00052/miR-126-5p/PIAS2 axis through JAK2/STAT3 signaling pathway.	Curcumin	26-34	protein inhibitor of activated STAT 2	Homo sapiens	93-98
35473503-14	2022	These results reveal that curcumin protects against RA by regulating the inc00052/miR-126-5p/PIAS2 axis through JAK2/STAT3 signaling pathway.	Curcumin	26-34	signal transducer and activator of transcription 3	Homo sapiens	117-122
34994998-9	2022	Curcumin-induced apoptosis was also mediated by the EGFR signaling pathway.	Curcumin	0-8	epidermal growth factor receptor	Homo sapiens	52-56
35229255-0	2022	Curcumin alleviates lipopolysaccharides-induced inflammation and apoptosis in vascular smooth muscle cells via inhibition of the NF-kappaB and JNK signaling pathways.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	129-138
34994998-10	2022	Combination treatment with curcumin and gefitinib (an EGFR inhibitor) synergistically potentiated the inhibitory effect of cell viability in A375.S2/VR cells.	Curcumin	27-35	epidermal growth factor receptor	Homo sapiens	54-58
35229255-0	2022	Curcumin alleviates lipopolysaccharides-induced inflammation and apoptosis in vascular smooth muscle cells via inhibition of the NF-kappaB and JNK signaling pathways.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	143-146
35229255-9	2022	Mechanistically, we found that curcumin attenuated LPS-induced cell damage in VSMCs via inhibition of NF-kappaB and the JNK signal pathway.	Curcumin	31-39	nuclear factor kappa B subunit 1	Homo sapiens	102-111
35229255-9	2022	Mechanistically, we found that curcumin attenuated LPS-induced cell damage in VSMCs via inhibition of NF-kappaB and the JNK signal pathway.	Curcumin	31-39	mitogen-activated protein kinase 8	Homo sapiens	120-123
35229255-10	2022	Curcumin can protect VSMCs from LPS induced inflammatory damage, which may be related to the blocking of NF-kappaB and the JNK signaling pathway.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	105-114
35229255-10	2022	Curcumin can protect VSMCs from LPS induced inflammatory damage, which may be related to the blocking of NF-kappaB and the JNK signaling pathway.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	123-126
35178811-6	2022	Curcumin supplementation significantly decreased homeostatic model assessment for insulin resistance (HOMA-IR), erythrocyte sedimentation rate, serum levels of high-sensitivity C-reactive protein and triglycerides, weight, body mass index, and waist circumference of patients compared with the placebo at the end of the study (p < .05 for all).	Curcumin	0-8	insulin	Homo sapiens	82-89
35417322-9	2022	Using curcumin-loaded niosomes decreased immune cell influx and the inflammatory mediators (MIP-1alpha, TNF-alpha and IFN-gamma) production in the lung, resulting in alleviated lung pathology following RSV infection.	Curcumin	6-14	tumor necrosis factor	Homo sapiens	104-113
35417322-9	2022	Using curcumin-loaded niosomes decreased immune cell influx and the inflammatory mediators (MIP-1alpha, TNF-alpha and IFN-gamma) production in the lung, resulting in alleviated lung pathology following RSV infection.	Curcumin	6-14	interferon gamma	Homo sapiens	118-127
35581079-5	2022	Hydrogels exhibited lower inflammatory response than mats and curcumin loaded scaffolds reduced TNF-alpha production.	Curcumin	62-70	tumor necrosis factor	Rattus norvegicus	96-105
35192145-7	2022	Curcumin attenuated TG-induced damage on cell viability and apoptosis and downregulated the protein levels of GRP78, pSer981-PERK, and pSer51-eIF2alpha.	Curcumin	0-8	heat shock protein family A (Hsp70) member 5	Homo sapiens	110-115
35191177-0	2022	Curcumin analog HO-3867 triggers apoptotic pathways through activating JNK1/2 signalling in human oral squamous cell carcinoma cells.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	71-77
35178811-6	2022	Curcumin supplementation significantly decreased homeostatic model assessment for insulin resistance (HOMA-IR), erythrocyte sedimentation rate, serum levels of high-sensitivity C-reactive protein and triglycerides, weight, body mass index, and waist circumference of patients compared with the placebo at the end of the study (p < .05 for all).	Curcumin	0-8	C-reactive protein	Homo sapiens	177-195
35362381-12	2022	CONCLUSIONS: Curcumin decreased the fructose-induced glycation level of the ACO2, NDUFS7, and DLAT proteins.	Curcumin	13-21	NADH:ubiquinone oxidoreductase core subunit S7	Mus musculus	82-88
35399832-0	2022	Curcumin Inhibits the Proliferation of Renal Cancer 786-O Cells through MTOR Signaling Pathway and Its Mechanism.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	72-76
35399832-1	2022	Objectives: The mechanism of curcumin inhibiting renal cancer 786-O cells proliferation through MTOR signaling pathway was investigated.	Curcumin	29-37	mechanistic target of rapamycin kinase	Homo sapiens	96-100
35399832-7	2022	Results: With curcumin concentration increasing, the expressions of MMP2, MMP9, MTOR, and p-MTOR proteins and the number of cells in the S phase decreased gradually, while number of cells in G1 and G2/M phases and cells apoptosis rate increased continuously.	Curcumin	14-22	mechanistic target of rapamycin kinase	Homo sapiens	80-84
35399832-7	2022	Results: With curcumin concentration increasing, the expressions of MMP2, MMP9, MTOR, and p-MTOR proteins and the number of cells in the S phase decreased gradually, while number of cells in G1 and G2/M phases and cells apoptosis rate increased continuously.	Curcumin	14-22	mechanistic target of rapamycin kinase	Homo sapiens	92-96
35399832-10	2022	Conclusions: Curcumin inhibits the proliferation, migration, and invasion and induces apoptosis of renal cancer 786-O cells by blocking the MTOR signaling pathway.	Curcumin	13-21	mechanistic target of rapamycin kinase	Homo sapiens	140-144
35454103-5	2022	Using a refined method for obtaining enriched Schwann cell cultures, we evaluated the neurotherapeutic action of low dose curcumin treatment on the PMP22 expression, and on the chaperones and autophagy/mammalian target of rapamycin (mTOR) pathways in Trembler-J and wild-type genotypes.	Curcumin	122-130	mechanistic target of rapamycin kinase	Homo sapiens	192-231
35345991-5	2022	RESULTS: The results showed that curcumin consumption could significantly reduce AST (-0.35, (-0.57 to -0.14)), total cholesterol (-0.81, (-1.34 to -0.27)), TG (-0.49, (-0.71 to -0.27)), and FBS (-0.28, (-0.46 to -0.09)) in patients with NAFLD.	Curcumin	33-41	solute carrier family 17 member 5	Homo sapiens	81-84
35347555-7	2022	RESULTS: After 12 weeks of supplementation with curcumin, the TNF-alpha plasma levels were significantly reduced (from 15.0 (8.23-73.3) to 6.17 (1.11-55.0) pg/mL, p = 0.01).	Curcumin	48-56	tumor necrosis factor	Homo sapiens	62-71
35347555-8	2022	CONCLUSION: 12 weeks of treatment with curcumin in HD patients resulted in a reduction in the biomarker of inflammation (TNF-alpha), confirming our previous hypothesis that curcumin has an anti-inflammatory effect.	Curcumin	39-47	tumor necrosis factor	Homo sapiens	121-130
35063475-12	2022	Notably, administration of curcumin upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its related downstream antioxidant molecules (SOD, CAT, HO-1, NQO1) and phase II detoxification enzyme-related molecules (GST, GSH, GSS, GCLC, GCLM) in the presence of AFB1 exposure.	Curcumin	27-35	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-109
35325302-5	2022	Since the genetic signature of microglia offers many potential targets for drug discovery, molecular docking followed by molecular dynamics (MD) simulations of cluster of differentiation 40 ligand (CD40L) and colony-stimulating factor 1 receptor (CSF1R) kinase domain protein with some known neuro-immunomodulators (Curcumin, Cannabidiol, Ginsenoside Rg1, Resveratrol, and Sulforaphane) has been evaluated.	Curcumin	316-324	CD40 ligand	Homo sapiens	198-203
35325302-6	2022	Curcumin and cannabidiol were observed likely to modulate CD40L and expression of cytokines and entry of inflammatory cells.	Curcumin	0-8	CD40 ligand	Homo sapiens	58-63
35289676-4	2022	Chlorogenic acid (CGA), curcumin (CUR), epigallocatechin gallate (EGCG), and resveratrol (RSV) can act as antioxidants that activate AMP-activated protein kinase (AMPK) to downregulate ROS, and as prooxidants to generate ROS, leading to the downregulation of NF-kappaB.	Curcumin	24-32	nuclear factor kappa B subunit 1	Homo sapiens	259-268
35289676-4	2022	Chlorogenic acid (CGA), curcumin (CUR), epigallocatechin gallate (EGCG), and resveratrol (RSV) can act as antioxidants that activate AMP-activated protein kinase (AMPK) to downregulate ROS, and as prooxidants to generate ROS, leading to the downregulation of NF-kappaB.	Curcumin	34-37	nuclear factor kappa B subunit 1	Homo sapiens	259-268
35408920-2	2022	Curcumin has been demonstrated to be able to modulate gene transcription and reduce ganglion cell apoptosis, downgrade VEGF, modulate glucose levels and decrease vascular dysfunction.	Curcumin	0-8	vascular endothelial growth factor A	Homo sapiens	119-123
35319355-10	2022	Curcumin acts by inhibition of various biological cancer pathways, including NF-kappaB, mTOR, complex I, cytokines, expression of p-p65, Ki67, and angiogenesis-associated genes.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	77-86
35319355-10	2022	Curcumin acts by inhibition of various biological cancer pathways, including NF-kappaB, mTOR, complex I, cytokines, expression of p-p65, Ki67, and angiogenesis-associated genes.	Curcumin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	88-92
35303193-0	2022	Curcumin attenuates inflammation of Macrophage-derived foam cells treated with Poly-L-lactic acid degradation via PPARgamma signaling pathway.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	114-123
35303193-6	2022	Foam cells were treated with pre-degraded PLLA powder, curcumin and PPARgamma inhibitor GW9662, and the expression of IL-6, IL-10, TNF-alpha, NF-kappab, PLA2 and PPARgamma were investigated by ELISA or RT-qPCR.	Curcumin	55-63	interleukin 6	Homo sapiens	118-122
35303193-6	2022	Foam cells were treated with pre-degraded PLLA powder, curcumin and PPARgamma inhibitor GW9662, and the expression of IL-6, IL-10, TNF-alpha, NF-kappab, PLA2 and PPARgamma were investigated by ELISA or RT-qPCR.	Curcumin	55-63	tumor necrosis factor	Homo sapiens	131-140
35303193-6	2022	Foam cells were treated with pre-degraded PLLA powder, curcumin and PPARgamma inhibitor GW9662, and the expression of IL-6, IL-10, TNF-alpha, NF-kappab, PLA2 and PPARgamma were investigated by ELISA or RT-qPCR.	Curcumin	55-63	nuclear factor kappa B subunit 1	Homo sapiens	142-151
35303193-6	2022	Foam cells were treated with pre-degraded PLLA powder, curcumin and PPARgamma inhibitor GW9662, and the expression of IL-6, IL-10, TNF-alpha, NF-kappab, PLA2 and PPARgamma were investigated by ELISA or RT-qPCR.	Curcumin	55-63	phospholipase A2 group IB	Homo sapiens	153-157
35303193-6	2022	Foam cells were treated with pre-degraded PLLA powder, curcumin and PPARgamma inhibitor GW9662, and the expression of IL-6, IL-10, TNF-alpha, NF-kappab, PLA2 and PPARgamma were investigated by ELISA or RT-qPCR.	Curcumin	55-63	peroxisome proliferator activated receptor gamma	Homo sapiens	162-171
35303193-8	2022	This present study was found that the inflammation of foam cells at the microenvironment of PLLA degraded products were significantly increased, and curcumin can attenuate the inflammation caused by the PLLA degradation via PPARgamma signal pathway.	Curcumin	149-157	peroxisome proliferator activated receptor gamma	Homo sapiens	224-233
35063475-0	2022	Curcumin mitigates aflatoxin B1-induced liver injury via regulating the NLRP3 inflammasome and Nrf2 signaling pathway.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
35063475-12	2022	Notably, administration of curcumin upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its related downstream antioxidant molecules (SOD, CAT, HO-1, NQO1) and phase II detoxification enzyme-related molecules (GST, GSH, GSS, GCLC, GCLM) in the presence of AFB1 exposure.	Curcumin	27-35	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115
35063475-12	2022	Notably, administration of curcumin upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its related downstream antioxidant molecules (SOD, CAT, HO-1, NQO1) and phase II detoxification enzyme-related molecules (GST, GSH, GSS, GCLC, GCLM) in the presence of AFB1 exposure.	Curcumin	27-35	catalase	Mus musculus	172-175
35063475-12	2022	Notably, administration of curcumin upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its related downstream antioxidant molecules (SOD, CAT, HO-1, NQO1) and phase II detoxification enzyme-related molecules (GST, GSH, GSS, GCLC, GCLM) in the presence of AFB1 exposure.	Curcumin	27-35	heme oxygenase 1	Mus musculus	177-181
35063475-13	2022	To summarize, our results indicated that curcumin could modulate the NLRP3 inflammasome and Nrf2 signaling pathways to attenuate AFB1-induced liver pyroptotic damage and oxidative stress.	Curcumin	41-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-96
35065811-0	2022	Corrigendum to "Curcumin activation of nuclear factor E2-related factor 2 gene (Nrf2): Prophylactic and therapeutic effect in nonalcoholic steatohepatitis (NASH)" (Life Sci.	Curcumin	16-24	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84
35080289-6	2022	Curcumin exhibited antiinflammatory pharmacological effects, as reflected by inhibition of inflammatory factors (e.g., interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha).	Curcumin	0-8	interleukin 6	Mus musculus	143-147
35205780-0	2022	Microsatellite Status and IkappaBalpha Expression Levels Predict Sensitivity to Pharmaceutical Curcumin in Colorectal Cancer Cells.	Curcumin	95-103	NFKB inhibitor alpha	Homo sapiens	26-38
35256924-8	2022	Moreover, curcumin administration or si-LINC00691 transfection alone inhibited p-Akt activity, further suppressed by combination treatment.	Curcumin	10-18	AKT serine/threonine kinase 1	Homo sapiens	81-84
35256924-11	2022	The precise molecular mechanism might be mediated through the Akt signaling pathway, providing a theoretical basis for the treatment of PTC with curcumin.	Curcumin	145-153	AKT serine/threonine kinase 1	Homo sapiens	62-65
35113098-0	2022	Curcumin alleviates hepatic steatosis by improving mitochondrial function in postnatal overfed rats and fatty L02 cells through the SIRT3 pathway.	Curcumin	0-8	sirtuin 3	Homo sapiens	132-137
35182412-0	2022	Curcumin Mitigates TNFalpha-Induced Caco-2 Cell Monolayer Permeabilization Through modulation of NF-kappaB, ERK1/2 and JNK Pathways.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	19-27
35182412-0	2022	Curcumin Mitigates TNFalpha-Induced Caco-2 Cell Monolayer Permeabilization Through modulation of NF-kappaB, ERK1/2 and JNK Pathways.	Curcumin	0-8	mitogen-activated protein kinase 3	Homo sapiens	108-114
35182412-0	2022	Curcumin Mitigates TNFalpha-Induced Caco-2 Cell Monolayer Permeabilization Through modulation of NF-kappaB, ERK1/2 and JNK Pathways.	Curcumin	0-8	mitogen-activated protein kinase 8	Homo sapiens	119-122
35182412-1	2022	SCOPE: This work studied the capacity of curcumin to inhibit TNFalpha-induced inflammation, oxidative stress, and loss of intestinal barrier integrity, characterizing the underlying mechanisms.	Curcumin	41-49	tumor necrosis factor	Homo sapiens	61-69
35182412-3	2022	TNFalpha caused an increase in interleukin (IL)-6 and IL-8 release which was inhibited by curcumin in a dose-dependent manner (IC50 = 3.4 muM for IL-6).	Curcumin	90-98	tumor necrosis factor	Homo sapiens	0-8
35182412-3	2022	TNFalpha caused an increase in interleukin (IL)-6 and IL-8 release which was inhibited by curcumin in a dose-dependent manner (IC50 = 3.4 muM for IL-6).	Curcumin	90-98	interleukin 6	Homo sapiens	31-49
35182412-3	2022	TNFalpha caused an increase in interleukin (IL)-6 and IL-8 release which was inhibited by curcumin in a dose-dependent manner (IC50 = 3.4 muM for IL-6).	Curcumin	90-98	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
35182412-3	2022	TNFalpha caused an increase in interleukin (IL)-6 and IL-8 release which was inhibited by curcumin in a dose-dependent manner (IC50 = 3.4 muM for IL-6).	Curcumin	90-98	interleukin 6	Homo sapiens	146-150
35182412-5	2022	Curcumin (2-8 muM) inhibited all these TNFalpha-triggered undesirable outcomes, mostly showing dose-dependent effects.	Curcumin	0-8	tumor necrosis factor	Homo sapiens	39-47
35182412-6	2022	CONCLUSION: The inhibition of NF-kappaB, ERK1/2 and JNK activation could be in part involved in the capacity of curcumin to mitigate intestinal inflammation, oxidant production, activation of redox-sensitive pathways, and prevention of monolayer permeabilization.	Curcumin	112-120	mitogen-activated protein kinase 3	Homo sapiens	41-47
35182412-6	2022	CONCLUSION: The inhibition of NF-kappaB, ERK1/2 and JNK activation could be in part involved in the capacity of curcumin to mitigate intestinal inflammation, oxidant production, activation of redox-sensitive pathways, and prevention of monolayer permeabilization.	Curcumin	112-120	mitogen-activated protein kinase 8	Homo sapiens	52-55
35300350-10	2021	Interestingly, lower expression of miR-27a by curcumin action enhanced the C/EBP homologous protein(CHOP) expression, leading to paraptosis.	Curcumin	46-54	microRNA 27a	Homo sapiens	35-42
35489078-0	2022	Protective Effect of Curcumin Against Gentamicin-induced Nephrotoxicity Mediated by p38 MAPK, Nuclear Factor- Kappa B, Nuclear Factor Erythroid 2-Related Factor 2.	Curcumin	21-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	119-162
35489078-11	2022	Additionaly, curcumin significantly decreased p-p38 MAPK positive cells and NFkB immunoreactivity, while significantly increasing Nrf2 immunoreactivity in the kidney tissue.	Curcumin	13-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	130-134
35489078-12	2022	CONCLUSION: We conclude that curcumin may attenuate gentamicininduced nephrotoxicity by supprresing the p38 MAPK and NFkB, and activating the Nrf2 signaling pathways.	Curcumin	29-37	NFE2 like bZIP transcription factor 2	Rattus norvegicus	142-146
35225298-9	2022	Curcumin-treated groups, with and without PZQ, resulted in higher significant Immunoreactivity score (IRS) for Bcl-2-associated X (BAX) and lower Interleukine- 17A (IL-17A), and Human epidermal growth factor (EGF), compared to the control.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	111-129
35225298-9	2022	Curcumin-treated groups, with and without PZQ, resulted in higher significant Immunoreactivity score (IRS) for Bcl-2-associated X (BAX) and lower Interleukine- 17A (IL-17A), and Human epidermal growth factor (EGF), compared to the control.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	131-134
35256924-7	2022	Curcumin administration or si-LINC00691 transfection alone promoted ATP levels, inhibited glucose uptake and lactic acid levels, and inhibited lactate dehydrogenase A and hexokinase 2 protein expression in B-CPAP cells, which were further enhanced by combination treatment.	Curcumin	0-8	lactate dehydrogenase A	Homo sapiens	143-166
35250410-8	2022	Results: Treatment with Curc and/or Lip acid showed effective reduction of NHPA-induced liver injury, demonstrated by reducing serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, as well as hepatic nitric oxide and malondialdehyde.	Curcumin	24-28	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	159-185
35215023-0	2022	Affibody Modified G-quadruplex DNA Micelles Incorporating Polymeric 5-Fluorodeoxyuridine for Targeted Delivery of Curcumin to Enhance Synergetic Therapy of HER2 Positive Gastric Cancer.	Curcumin	114-122	erb-b2 receptor tyrosine kinase 2	Homo sapiens	156-160
35215023-4	2022	To achieve synergistic efficacy with hydrophobic drugs, curcumin (Cur) is co-loaded into affi-F/GQs micelles to prepare the dual drug-loaded DNA micelles (Cur@affi-F/GQs), in which affibody is employed as a targeting moiety to facilitate HER2 receptor-mediated uptake.	Curcumin	56-64	erb-b2 receptor tyrosine kinase 2	Homo sapiens	238-242
35300350-10	2021	Interestingly, lower expression of miR-27a by curcumin action enhanced the C/EBP homologous protein(CHOP) expression, leading to paraptosis.	Curcumin	46-54	DNA damage inducible transcript 3	Homo sapiens	100-104
35300350-11	2021	Curcumin can inhibit miR-21 expression and consequently activate apoptosis through caspase 3 and death receptor (DR) 4 and 5 activation.	Curcumin	0-8	caspase 3	Homo sapiens	83-92
35205780-6	2022	Most curcumin-sensitive CRC cell lines were microsatellite stable and expressed high levels of IkappaBalpha.	Curcumin	5-13	NFKB inhibitor alpha	Homo sapiens	95-107
35205780-9	2022	As curcumin"s mode of action, inhibition of NF-kappaB p65 activation via IkappaBalpha was identified.	Curcumin	3-11	NFKB inhibitor alpha	Homo sapiens	73-85
35205780-10	2022	In consequence, we hypothesize that novel curcumin formulations-either alone or, more likely, in combination with standard therapeutics-can be expected to prove clinically beneficial for CRC patients with high IkappaBalpha expression levels.	Curcumin	42-50	NFKB inhibitor alpha	Homo sapiens	210-222
35151347-0	2022	Curcumin assists anti-EV71 activity of IFN-alpha by inhibiting IFNAR1 reduction in SH-SY5Y cells.	Curcumin	0-8	interferon alpha 1	Homo sapiens	39-48
35242748-8	2022	Curcumin/TPP-CZL nanomicelles could significantly reduce the mitochondrial membrane potential, increase the expression of pro apoptotic protein Bcl-2, and reduce the expression of antiapoptotic Bax protein, and these results were significantly better than curcumin/CZL nanomicelles and curcumin.	Curcumin	0-8	BCL2 apoptosis regulator	Homo sapiens	144-149
35242748-8	2022	Curcumin/TPP-CZL nanomicelles could significantly reduce the mitochondrial membrane potential, increase the expression of pro apoptotic protein Bcl-2, and reduce the expression of antiapoptotic Bax protein, and these results were significantly better than curcumin/CZL nanomicelles and curcumin.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	194-197
35242748-8	2022	Curcumin/TPP-CZL nanomicelles could significantly reduce the mitochondrial membrane potential, increase the expression of pro apoptotic protein Bcl-2, and reduce the expression of antiapoptotic Bax protein, and these results were significantly better than curcumin/CZL nanomicelles and curcumin.	Curcumin	256-264	BCL2 associated X, apoptosis regulator	Homo sapiens	194-197
35242748-8	2022	Curcumin/TPP-CZL nanomicelles could significantly reduce the mitochondrial membrane potential, increase the expression of pro apoptotic protein Bcl-2, and reduce the expression of antiapoptotic Bax protein, and these results were significantly better than curcumin/CZL nanomicelles and curcumin.	Curcumin	286-294	BCL2 associated X, apoptosis regulator	Homo sapiens	194-197
35151347-12	2022	However, Curcumin addition restored IFN-alpha-mediated ISRE activity thus significantly inhibiting EV71 replication.	Curcumin	9-17	interferon alpha 1	Homo sapiens	36-45
35151347-14	2022	CONCLUSION: These data demonstrate that Curcumin assists anti-EV71 activity of IFN-alpha by inhibiting IFNAR1 reduction via ubiquitin-proteasome disruption in SH-SY5Y cells.	Curcumin	40-48	interferon alpha 1	Homo sapiens	79-88
35425501-1	2022	A curcumin derivative conjugated with Gd-DO3A (Gd-DO3A-Comp.B) was synthesised as an MRI contrast agent for detecting the amyloid-beta (Abeta) fibrillation process.	Curcumin	2-10	amyloid beta precursor protein	Homo sapiens	122-134
35189631-10	2022	Furthermore, curcumin positively regulated the expression of Nrf2, HO-1, and SOD1 mRNAs in cells treated with 0.1 and 0.5 muM doxazosin.	Curcumin	13-21	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65
35189631-10	2022	Furthermore, curcumin positively regulated the expression of Nrf2, HO-1, and SOD1 mRNAs in cells treated with 0.1 and 0.5 muM doxazosin.	Curcumin	13-21	superoxide dismutase 1	Homo sapiens	77-81
35189631-11	2022	Moreover, the Bcl-2/Bax ratio was higher in cells that were treated with curcumin before doxazosin or carvedilol.	Curcumin	73-81	BCL2 apoptosis regulator	Homo sapiens	14-19
35189631-11	2022	Moreover, the Bcl-2/Bax ratio was higher in cells that were treated with curcumin before doxazosin or carvedilol.	Curcumin	73-81	BCL2 associated X, apoptosis regulator	Homo sapiens	20-23
35189631-12	2022	The present study demonstrates that curcumin controls doxazosin- and carvedilol-induced cytotoxicity and morphological changes in HepG2 cells possibly by overexpression of Nrf2.	Curcumin	36-44	NFE2 like bZIP transcription factor 2	Homo sapiens	172-176
35425501-1	2022	A curcumin derivative conjugated with Gd-DO3A (Gd-DO3A-Comp.B) was synthesised as an MRI contrast agent for detecting the amyloid-beta (Abeta) fibrillation process.	Curcumin	2-10	amyloid beta precursor protein	Homo sapiens	136-141
35277071-2	2022	Curcumin, a potent antioxidant, has been reported to suppress inflammation via down regulation of NF-kappaB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	98-107
35132919-9	2022	In conclusion, Cur-loaded SLNs effectively prevented the liver damage induced by PCM overdose through alleviating the oxidative stress and inhibiting the serum and hepatic iNOS expression in an effect comparable to NAC and better than raw Cur.	Curcumin	15-18	nitric oxide synthase 2	Rattus norvegicus	172-176
35137655-3	2022	In this study, a composite chitosan electrospun nanofibrous material containing Cur@beta-CD/AgNPs nanoparticles composed of silver and curcumin possessed synergic effects on antibacterial activity and wound healing.	Curcumin	135-143	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	84-91
35164400-0	2022	Fluorogenic Detection of Human Serum Albumin Using Curcumin-Capped Mesoporous Silica Nanoparticles.	Curcumin	51-59	albumin	Homo sapiens	31-44
35164400-1	2022	Mesoporous silica nanoparticles loaded with rhodamine B and capped with curcumin are used for the selective and sensitive fluorogenic detection of human serum albumin (HSA).	Curcumin	72-80	albumin	Homo sapiens	153-166
35040210-5	2022	Although the clinical manifestations and laboratory parameters improved via the nano-curcumin treatment, the mRNA expression of IFN-gamma (p = 0.006) and TNF-alpha (p = 0.04) were significantly reduced.	Curcumin	85-93	interferon gamma	Homo sapiens	128-137
35040210-5	2022	Although the clinical manifestations and laboratory parameters improved via the nano-curcumin treatment, the mRNA expression of IFN-gamma (p = 0.006) and TNF-alpha (p = 0.04) were significantly reduced.	Curcumin	85-93	tumor necrosis factor	Homo sapiens	154-163
35040210-6	2022	Besides, a considerable difference was observed between the nano-curcumin and control groups in the expression of IFN-gamma (p = 0.001), IL-1beta (p = 0.0002), and IL-6 (p = 0.008).	Curcumin	65-73	interferon gamma	Homo sapiens	114-123
35040210-6	2022	Besides, a considerable difference was observed between the nano-curcumin and control groups in the expression of IFN-gamma (p = 0.001), IL-1beta (p = 0.0002), and IL-6 (p = 0.008).	Curcumin	65-73	interleukin 6	Homo sapiens	164-168
35178958-0	2022	(Curcumin improves cardiac fibrosis by inhibiting endothelial-mesenchymal transition through NRF2-DDAH-ADMA-NO pathway).	Curcumin	1-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	93-97
35078445-12	2022	In vitro, we further confirmed that curcumin significantly downregulated the expression of AURKA, CDK1, and TOP2A genes, while significantly upregulated the expression of CYP2B6, CYP2C9, and CYP3A4 genes.	Curcumin	36-44	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	191-197
35132306-0	2022	Curcumin Targeting NF-kappaB/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	19-28
35078445-13	2022	CONCLUSIONS: Our results provided a novel panel of AURKA, CDK1, TOP2A, CYP2C9, and CYP3A4 candidate genes for curcumin related chemotherapy of hepatocellular carcinoma.	Curcumin	110-118	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	83-89
35053230-0	2022	Nrf2-Related Therapeutic Effects of Curcumin in Different Disorders.	Curcumin	36-44	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
34931204-0	2022	The inhibition of interaction with serum albumin enhances the physiological activity of curcumin by increasing its cellular uptake.	Curcumin	88-96	albumin	Homo sapiens	35-48
35017319-9	2022	We found that curcumin supplementation increased hepatic insulin-degrading enzyme (IDE) expression levels and preserved islet integrity, both outcomes that are beneficial to preserving good health with age.	Curcumin	14-22	insulin degrading enzyme	Mus musculus	57-81
35017319-9	2022	We found that curcumin supplementation increased hepatic insulin-degrading enzyme (IDE) expression levels and preserved islet integrity, both outcomes that are beneficial to preserving good health with age.	Curcumin	14-22	insulin degrading enzyme	Mus musculus	83-86
35082487-0	2022	Erratum: Inhibition of JNK Phosphorylation by Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury (Corrigendum).	Curcumin	46-54	mitogen-activated protein kinase 8	Homo sapiens	23-26
35053230-3	2022	Nrf2-related effects of curcumin have been investigated in different contexts, including gastrointestinal disorders, ischemia-reperfusion injury, diabetes mellitus, nervous system diseases, renal diseases, pulmonary diseases, cardiovascular diseases as well as cancers.	Curcumin	24-32	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
35053230-4	2022	In the current review, we discuss the Nrf2-mediated therapeutic effects of curcumin in these conditions.	Curcumin	75-83	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
35053230-5	2022	The data reviewed in the current manuscript indicates curcumin as a potential activator of Nrf2 and a therapeutic substance for the protection of cells in several pathological conditions.	Curcumin	54-62	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
35011106-8	2022	Curcumin significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-gamma, and IL-4) and lipid peroxidation.	Curcumin	0-8	interferon gamma	Homo sapiens	73-82
35011106-8	2022	Curcumin significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-gamma, and IL-4) and lipid peroxidation.	Curcumin	0-8	interleukin 4	Homo sapiens	88-92
35517894-0	2022	Curcumin Prevents Epithelial-to Mesenchymal Transition-Mediated Ovarian Cancer Progression through NRF2/ETBR/ET-1 Axis and Preserves Mitochondria Biogenesis in Kidney after Cisplatin Administration.	Curcumin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	99-103
35517894-0	2022	Curcumin Prevents Epithelial-to Mesenchymal Transition-Mediated Ovarian Cancer Progression through NRF2/ETBR/ET-1 Axis and Preserves Mitochondria Biogenesis in Kidney after Cisplatin Administration.	Curcumin	0-8	endothelin 1	Rattus norvegicus	109-113
35517894-5	2022	Moreover, curcumin augments the affinity of the antioxidant enzyme, while inhibits endothelin-1 (ET-1) signalling.	Curcumin	10-18	endothelin 1	Rattus norvegicus	83-95
35517894-5	2022	Moreover, curcumin augments the affinity of the antioxidant enzyme, while inhibits endothelin-1 (ET-1) signalling.	Curcumin	10-18	endothelin 1	Rattus norvegicus	97-101
35517894-8	2022	The kidney phenotype in the ovarian cancer rat model after cisplatin +- curcumin administration will also be analyzed Results: Co-treatment of cisplatin with curcumin enhanced the expression of a gene involved in apoptosis in association with NRF2 enhancement, thus activated ETBR-mediated ET-1 clearance in SKOV3 cell and ovarian cancer model in rat.	Curcumin	158-166	NFE2 like bZIP transcription factor 2	Rattus norvegicus	243-247
35517894-8	2022	The kidney phenotype in the ovarian cancer rat model after cisplatin +- curcumin administration will also be analyzed Results: Co-treatment of cisplatin with curcumin enhanced the expression of a gene involved in apoptosis in association with NRF2 enhancement, thus activated ETBR-mediated ET-1 clearance in SKOV3 cell and ovarian cancer model in rat.	Curcumin	158-166	endothelin 1	Rattus norvegicus	290-294
35517894-9	2022	Moreover, curcumin treatment improved mitochondria biogenesis markers such as PGC-1alpha and TFAM and prevented the elevated of ET-1-mediated renal fibrosis and apoptosis in kidney isolated from cisplatin-treated ovarian cancer rat.	Curcumin	10-18	PPARG coactivator 1 alpha	Rattus norvegicus	78-88
35517894-9	2022	Moreover, curcumin treatment improved mitochondria biogenesis markers such as PGC-1alpha and TFAM and prevented the elevated of ET-1-mediated renal fibrosis and apoptosis in kidney isolated from cisplatin-treated ovarian cancer rat.	Curcumin	10-18	endothelin 1	Rattus norvegicus	128-132
35435039-10	2022	This coincided with 3.2-fold lower area under the concentration time curve (AUC) of IL-8 from day -3 to day 14 in curcumin group compared with control group (P = 0.039).	Curcumin	114-122	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
35530367-4	2022	In addition, GA/CUR nanocomplexes demonstrated high intracellular uptake into macrophages (RAW264.7 cells), consequently reducing the release of the pro-inflammatory cytokine tumor necrosis factor-alpha.	Curcumin	16-19	tumor necrosis factor	Mus musculus	175-202
34980778-9	2022	Mechanistically, curcumin + HH suppressed protein expression of stromal cell-derived factor-1 (SDF-1), CXC chemokine receptor 4 (CXCR4), p-Akt, and c-fos while enhancing protein expression of nerve growth factor (NGF) in the dorsal root ganglia (DRG) of model rats.	Curcumin	17-25	AKT serine/threonine kinase 1	Rattus norvegicus	139-142
34980778-10	2022	Curcumin + HH inhibited the expression and production of interleukin 1beta (IL-1beta), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and p65 nuclear factor kappa B (NF-kappaB) in the DRG.	Curcumin	0-8	interleukin 1 beta	Rattus norvegicus	57-74
34980778-10	2022	Curcumin + HH inhibited the expression and production of interleukin 1beta (IL-1beta), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and p65 nuclear factor kappa B (NF-kappaB) in the DRG.	Curcumin	0-8	interleukin 1 alpha	Rattus norvegicus	76-84
34980778-10	2022	Curcumin + HH inhibited the expression and production of interleukin 1beta (IL-1beta), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and p65 nuclear factor kappa B (NF-kappaB) in the DRG.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	113-140
34980778-10	2022	Curcumin + HH inhibited the expression and production of interleukin 1beta (IL-1beta), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and p65 nuclear factor kappa B (NF-kappaB) in the DRG.	Curcumin	0-8	tumor necrosis factor	Rattus norvegicus	142-151
34980778-10	2022	Curcumin + HH inhibited the expression and production of interleukin 1beta (IL-1beta), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and p65 nuclear factor kappa B (NF-kappaB) in the DRG.	Curcumin	0-8	synaptotagmin 1	Rattus norvegicus	158-161
35435039-11	2022	We conclude that curcumin mitigates toxicities of high-dose melphalan, possibly through IL-8 modulation.	Curcumin	17-25	C-X-C motif chemokine ligand 8	Homo sapiens	88-92
35180907-0	2022	Hyaluronic Acid Modified Curcumin-Loaded Chitosan Nanoparticles Inhibit Chondrocyte Apoptosis to Attenuate Osteoarthritis via Upregulation of Activator Protein 1 and RUNX Family Transcription Factor 2.	Curcumin	25-33	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	142-161
35583244-7	2022	Cur + TQ combination significantly increased caspase-3 and decreased PI3K and AKT protein levels.	Curcumin	0-5	caspase 3	Homo sapiens	45-54
35583244-7	2022	Cur + TQ combination significantly increased caspase-3 and decreased PI3K and AKT protein levels.	Curcumin	0-5	AKT serine/threonine kinase 1	Homo sapiens	78-81
35106036-0	2022	In silico docking and ADME study of deketene curcumin derivatives (DKC) as an aromatase inhibitor or antagonist to the estrogen-alpha positive receptor (Eralpha+): potent application of breast cancer.	Curcumin	45-53	estrogen receptor 1	Homo sapiens	153-160
34957920-7	2022	Curcumin"s compatibility with formulation additives was confirmed by ATR-FTIR analysis.	Curcumin	0-8	ATR serine/threonine kinase	Homo sapiens	69-72
35571299-0	2022	Role of nano curcumin on superoxide dismutase levels in leukoplakia.	Curcumin	13-21	superoxide dismutase 1	Homo sapiens	25-45
35571299-4	2022	Aims: Role of nano curcumin on superoxide dismutase (SOD) levels in leukoplakia patients" pre- and post-treatment.	Curcumin	19-27	superoxide dismutase 1	Homo sapiens	31-51
35571299-4	2022	Aims: Role of nano curcumin on superoxide dismutase (SOD) levels in leukoplakia patients" pre- and post-treatment.	Curcumin	19-27	superoxide dismutase 1	Homo sapiens	53-56
35264205-4	2022	Curcumin is proposed harboring excellent ability to resist oxidative stress through Nrf2 activation and its newly found ability to chelate iron.	Curcumin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	84-88
33438085-9	2021	CONCLUSION: The oral supplementation of curcumin for three months seems to reduce p-CS plasma levels in HD patients, suggesting a gut microbiota modulation.	Curcumin	40-48	citrate synthase	Homo sapiens	84-86
34055082-5	2021	It was found that curcumin pretreatment significantly improved neurological scores, decreased infarct size, and protected synaptic remodeling of hippocampal neurons and upregulated the protein expression level of tight junction proteins, ZO-1, occludin and claudin-5 in ischemic rat brains.	Curcumin	18-26	occludin	Rattus norvegicus	244-252
34055082-5	2021	It was found that curcumin pretreatment significantly improved neurological scores, decreased infarct size, and protected synaptic remodeling of hippocampal neurons and upregulated the protein expression level of tight junction proteins, ZO-1, occludin and claudin-5 in ischemic rat brains.	Curcumin	18-26	claudin 5	Rattus norvegicus	257-266
33539684-4	2021	In addition, curcumin decreased ALDH activity and the expression of stemness markers (CD133, EpCAM, Oct4).	Curcumin	13-21	prominin 1	Homo sapiens	86-91
33713277-0	2021	Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway.	Curcumin	0-8	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	20-24
33713277-3	2021	Curcumin can suppress oncogenicity of many cancer cells, yet the effect and mechanism of curcumin in LGR5(+) colorectal cancer stem cells (CSCs) have not been studied.	Curcumin	89-97	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	101-105
33713277-4	2021	In this study, we studied the effect of curcumin on LGR5(+) colorectal CSCs using the experiments of tumorsphere formation, cell viability and cell apoptosis.	Curcumin	40-48	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	52-56
33713277-6	2021	Our results showed that curcumin inhibited tumorsphere formation, decreased cell viability in a dose-dependent manner, and also promoted apoptosis of LGR5(+) colorectal CSCs.	Curcumin	24-32	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	150-154
33713277-7	2021	Next, we found curcumin induced autophagy of LGR5(+) colorectal CSCs.	Curcumin	15-23	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	45-49
33713277-8	2021	When LGR5(+) colorectal CSCs were co-treated with curcumin and the autophagy inhibitor (hydroxychloroquine), curcumin-induced cell proliferation inhibition decreased.	Curcumin	50-58	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	5-9
33713277-8	2021	When LGR5(+) colorectal CSCs were co-treated with curcumin and the autophagy inhibitor (hydroxychloroquine), curcumin-induced cell proliferation inhibition decreased.	Curcumin	109-117	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	5-9
33713277-9	2021	In addition, we also found that curcumin inhibited the extracellular matrix (ECM)-receptor interaction pathway via the downregulation of the following genes: GP1BB, COL9A3, COMP, AGRN, ITGB4, LAMA5, COL2A1, ITGB6, ITGA1, and TNC.	Curcumin	32-40	integrin subunit beta 4	Homo sapiens	185-190
33713277-11	2021	In conclusion, curcumin suppressed LGR5(+) colorectal CSCs, potentially by inducing autophagy and repressing the oncogenic TFAP2A-mediated ECM pathway.	Curcumin	15-23	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	35-39
34976224-11	2022	Curcumin alleviated LPS-mediated sepsis by suppressing the activities of mitochondrial STAT3 and NF-kappaB.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	87-92
34976224-11	2022	Curcumin alleviated LPS-mediated sepsis by suppressing the activities of mitochondrial STAT3 and NF-kappaB.	Curcumin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-106
33496266-4	2021	Liver weights and plasma ApoA-II and high-density lipoprotein concentrations were significantly elevated in curcumin-supplemented groups.	Curcumin	108-116	apolipoprotein A-II	Mus musculus	25-32
33496266-5	2021	RNA-sequence analysis revealed that curcumin intake affected hepatic lipid metabolism via the peroxisome proliferator-activated receptor (PPAR) pathway, especially PPARalpha activation, resulting in increased Apoa2 mRNA expression.	Curcumin	36-44	apolipoprotein A-II	Mus musculus	209-214
33160958-10	2021	Curcumin also increased the expression of proteins involved in neurogenesis (including Ngn2, Pax6 and NeuroD 1) and the Wnt/beta-catenin signaling pathway.	Curcumin	0-8	neurogenic differentiation 1	Mus musculus	102-110
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	Curcumin	86-94	angiotensin converting enzyme 2	Homo sapiens	197-202
33459225-7	2021	Of the compounds addressed in this review, 7 phenolic compounds, including quercetin, curcumin, naringenin, luteolin, hesperidin, mangiferin, and gallic acid showed binding affinity with molecular ACE-2 target in silico, and 1, esculetin, decreased ACE-2 expression in vivo.	Curcumin	86-94	angiotensin converting enzyme 2	Homo sapiens	249-254
32918794-7	2021	However, following all curcumin pretreatment, the serum levels of kidney injury indicators and NGAL were decreased in the urine compared to those in the NS and CMCNa groups (P < .05), whereas renal SOD and CAT activities were increased and MDA was decreased (P < .05).	Curcumin	23-31	lipocalin 2	Rattus norvegicus	95-99
32918794-10	2021	Furthermore, iNOS and COX-2 expression and inflammatory factor levels were decreased after curcumin treatment.	Curcumin	91-99	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	22-27
33017608-0	2021	Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKCbeta/p66Shc axis and activation of FOXO-3a.	Curcumin	0-8	forkhead box O3	Rattus norvegicus	137-144
33017608-6	2021	Mechanistically, Curcumin reduced mRNA and protein levels of collagen I/III and transforming growth factor- beta-1 (TGF-beta1), reduced inflammatory cytokines levels, improved markers of mitochondrial function, and supressed the release of cytochrome-c and the activation of caspase-3.	Curcumin	17-25	caspase 3	Rattus norvegicus	275-284
33017608-7	2021	In the kidneys of both control and diabetic rats, Curcumin reduced the levels of reactive oxygen species (ROS), increased mRNA levels of manganese superoxide dismutase (MnSOD) and gamma-glutamyl ligase (GCL-c), increased glutathione (GSH) and protein levels of Bcl-2 and MnSOD, and increased the nuclear levels of nuclear factor2 (Nrf2) and FOXO-3a.	Curcumin	50-58	forkhead box O3	Rattus norvegicus	341-348
33335121-0	2020	Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway.	Curcumin	0-8	neurotrophic receptor tyrosine kinase 2	Homo sapiens	92-96
33335121-6	2020	Blocking the BDNF/TrkB pathway reversed the neuroprotective effects of curcumin, which were imparted by decreasing the PRV-induced upregulation of nitric oxide synthase expression, repressing the PRV-activated mitochondrial apoptotic pathway, and mitochondrial dysfunction.	Curcumin	71-79	neurotrophic receptor tyrosine kinase 2	Homo sapiens	18-22
33335121-7	2020	To conclude, curcumin exhibited a neuroprotective role against PRV infection by upregulating the BDNF/TrkB pathway.	Curcumin	13-21	neurotrophic receptor tyrosine kinase 2	Homo sapiens	102-106
33231238-2	2020	Herein, we designed a fibroblast activation protein-alpha (FAP-alpha)-adaptive polymeric micelle based on hyaluronic acid and curcumin conjugates.	Curcumin	126-134	fibroblast activation protein alpha	Homo sapiens	22-57
33231238-2	2020	Herein, we designed a fibroblast activation protein-alpha (FAP-alpha)-adaptive polymeric micelle based on hyaluronic acid and curcumin conjugates.	Curcumin	126-134	fibroblast activation protein alpha	Homo sapiens	59-68
33171062-6	2020	Mechanistically, curcumin inactivates the mechanistic target of rapamycin complex 1 (mTORC1), the upstream regulator of rDNA transcription and autophagy induction, by inhibiting mTOR lysosomal localization.	Curcumin	17-25	CREB regulated transcription coactivator 1	Mus musculus	85-91
32623920-0	2020	GSK-3beta inhibition by curcumin mitigates amyloidogenesis via TFEB activation and anti-oxidative Activity in human neuroblastoma cells.	Curcumin	24-32	glycogen synthase kinase 3 alpha	Homo sapiens	0-9
32623920-0	2020	GSK-3beta inhibition by curcumin mitigates amyloidogenesis via TFEB activation and anti-oxidative Activity in human neuroblastoma cells.	Curcumin	24-32	transcription factor EB	Homo sapiens	63-67
32623920-5	2020	In this study, we demonstrated that curcumin regulated TFEB export signaling via inhibition of glycogen synthase kinase-3beta (GSK-3beta); GSK-3beta was inactivated by curcumin, leading to reduced phosphorylation of TFEB.	Curcumin	36-44	transcription factor EB	Homo sapiens	55-59
32623920-5	2020	In this study, we demonstrated that curcumin regulated TFEB export signaling via inhibition of glycogen synthase kinase-3beta (GSK-3beta); GSK-3beta was inactivated by curcumin, leading to reduced phosphorylation of TFEB.	Curcumin	36-44	glycogen synthase kinase 3 beta	Homo sapiens	95-125
32623920-5	2020	In this study, we demonstrated that curcumin regulated TFEB export signaling via inhibition of glycogen synthase kinase-3beta (GSK-3beta); GSK-3beta was inactivated by curcumin, leading to reduced phosphorylation of TFEB.	Curcumin	36-44	glycogen synthase kinase 3 alpha	Homo sapiens	127-136
32623920-5	2020	In this study, we demonstrated that curcumin regulated TFEB export signaling via inhibition of glycogen synthase kinase-3beta (GSK-3beta); GSK-3beta was inactivated by curcumin, leading to reduced phosphorylation of TFEB.	Curcumin	36-44	glycogen synthase kinase 3 alpha	Homo sapiens	139-148
32623920-5	2020	In this study, we demonstrated that curcumin regulated TFEB export signaling via inhibition of glycogen synthase kinase-3beta (GSK-3beta); GSK-3beta was inactivated by curcumin, leading to reduced phosphorylation of TFEB.	Curcumin	36-44	transcription factor EB	Homo sapiens	216-220
32623920-5	2020	In this study, we demonstrated that curcumin regulated TFEB export signaling via inhibition of glycogen synthase kinase-3beta (GSK-3beta); GSK-3beta was inactivated by curcumin, leading to reduced phosphorylation of TFEB.	Curcumin	168-176	glycogen synthase kinase 3 alpha	Homo sapiens	139-148
32623920-7	2020	In addition, we showed that curcumin induced the degradation of amyloidogenic proteins, including amyloid-beta precursor protein and alpha-synuclein, through the TFEB-autophagy/lysosomal pathway.	Curcumin	28-36	transcription factor EB	Homo sapiens	162-166
32623920-8	2020	In conclusion, curcumin regulates autophagy by controlling TFEB through the inhibition of GSK-3beta, and increases antioxidant gene expression in human neuroblastoma cells.	Curcumin	15-23	transcription factor EB	Homo sapiens	59-63
32623920-8	2020	In conclusion, curcumin regulates autophagy by controlling TFEB through the inhibition of GSK-3beta, and increases antioxidant gene expression in human neuroblastoma cells.	Curcumin	15-23	glycogen synthase kinase 3 alpha	Homo sapiens	90-99
34047412-8	2021	Curcumin significantly downregulated Rac1 and Fn14 gene expression and significantly decreased p53, NF-kappaB p65, INF-gamma, and PUMA levels in the cardiac tissue.	Curcumin	0-8	Rac family small GTPase 1	Rattus norvegicus	37-41
34041781-6	2021	AOPP levels decreased significantly in the curcumin protective group (p<0.05) (p = 0.009) but the decrease in the treatment group was not found significant (p> 0.05), (p = 0.073).	Curcumin	43-51	peroxiredoxin 5	Mus musculus	0-4
34041781-12	2021	The significant CAT activities were found in both the curcumin protective group and the curcumin treatment group AOPP values decreased in curcumin protective group MDA levels decreased significantly in the curcumin protective group This article is protected by copyright.	Curcumin	88-96	peroxiredoxin 5	Mus musculus	113-117
34041781-12	2021	The significant CAT activities were found in both the curcumin protective group and the curcumin treatment group AOPP values decreased in curcumin protective group MDA levels decreased significantly in the curcumin protective group This article is protected by copyright.	Curcumin	88-96	peroxiredoxin 5	Mus musculus	113-117
34041781-12	2021	The significant CAT activities were found in both the curcumin protective group and the curcumin treatment group AOPP values decreased in curcumin protective group MDA levels decreased significantly in the curcumin protective group This article is protected by copyright.	Curcumin	88-96	peroxiredoxin 5	Mus musculus	113-117
33037778-4	2020	Herein, we formulated nanotized conjugate of curcumin and compound 6 (cur-compound 6) in the size range of 30-90 nm as observed via TEM, AFM and DLS analysis in the study.	Curcumin	45-53	tenomodulin	Mus musculus	132-135
33489032-7	2020	Western blot analysis showed that, after transfection with APOE4, the expression of total nuclear factor kappa B (NF-kappaB) p65 and p-NF-kappaB p65 in the nucleus was increased, and curcumin inhibited the nuclear translocation of p65.	Curcumin	183-191	RELA proto-oncogene, NF-kB subunit	Homo sapiens	135-148
32519340-6	2020	Curcumin affects different molecular pathways such as vascular endothelial growth factors, nuclear factor-kappaB (NF-kappaB), mammalian target of rapamycin, PI3/Akt, microRNAs, and long noncoding RNAs in treatment of lung cancer.	Curcumin	0-8	peptidase inhibitor 3	Homo sapiens	157-160
34051214-5	2021	Curcumin also increased the phosphorylation of heat shock factor 1 (HSF1), a well-known transcription factor of HSP70.	Curcumin	0-8	heat shock transcription factor 1	Homo sapiens	47-66
34051214-5	2021	Curcumin also increased the phosphorylation of heat shock factor 1 (HSF1), a well-known transcription factor of HSP70.	Curcumin	0-8	heat shock transcription factor 1	Homo sapiens	68-72
32979659-0	2020	Computational insights into the binding mode of curcumin analogues against EP300 HAT domain as potent acetyltransferase inhibitors.	Curcumin	48-56	E1A binding protein p300	Homo sapiens	75-80
34029211-0	2021	Curcumin inhibits the proliferation and migration of vascular smooth muscle cells by targeting the chemerin / CMKLR1 / LCN2 axis.	Curcumin	0-8	lipocalin 2	Mus musculus	119-123
32979659-5	2020	Currently, a few EP300 inhibitors are known, among which curcumin is the most widely investigated molecule.	Curcumin	57-65	E1A binding protein p300	Homo sapiens	17-22
34029211-7	2021	Furthermore, we discovered that Lipocalin-2 (LCN2) acts as a key factor involved in CMKLR1-mediated VSMCs proliferation and migration via the p38 / MAPK and Wnt / beta-catenin signaling pathways, and we demonstrated that curcumin inhibits VSMCs proliferation and migration by inhibiting chemerin / CMKLR1 / LCN2, thereby reducing AS progression.	Curcumin	221-229	lipocalin 2	Mus musculus	32-43
33561649-10	2021	Overall, the study emphasized that curcumin possesses a strong binding ability with host-specific receptors, furin and ACE2.	Curcumin	35-43	furin, paired basic amino acid cleaving enzyme	Homo sapiens	109-114
34029211-7	2021	Furthermore, we discovered that Lipocalin-2 (LCN2) acts as a key factor involved in CMKLR1-mediated VSMCs proliferation and migration via the p38 / MAPK and Wnt / beta-catenin signaling pathways, and we demonstrated that curcumin inhibits VSMCs proliferation and migration by inhibiting chemerin / CMKLR1 / LCN2, thereby reducing AS progression.	Curcumin	221-229	lipocalin 2	Mus musculus	45-49
33997938-0	2022	Curcumin Inhibits Viability of Clear Cell Renal Cell Carcinoma by Down-Regulating ADAMTS18 Gene Methylation though NF-kappa B and AKT Signaling Pathway.	Curcumin	0-8	ADAM metallopeptidase with thrombospondin type 1 motif 18	Homo sapiens	82-90
33997938-6	2022	Up-regulation of ADAMTS18 gene expression with down-regulation of ADAMTS18 gene methylation was reflected after curcumin treatment, accompanied by down-regulation of nuclear factor kappa B (NF-kappa kB) related protein (p65 and pp65), AKT related protein (AKT and pAKT), and NF-kappa B/AKT common related protein MMP-2.	Curcumin	112-120	ADAM metallopeptidase with thrombospondin type 1 motif 18	Homo sapiens	17-25
33997938-6	2022	Up-regulation of ADAMTS18 gene expression with down-regulation of ADAMTS18 gene methylation was reflected after curcumin treatment, accompanied by down-regulation of nuclear factor kappa B (NF-kappa kB) related protein (p65 and pp65), AKT related protein (AKT and pAKT), and NF-kappa B/AKT common related protein MMP-2.	Curcumin	112-120	ADAM metallopeptidase with thrombospondin type 1 motif 18	Homo sapiens	66-74
33997938-6	2022	Up-regulation of ADAMTS18 gene expression with down-regulation of ADAMTS18 gene methylation was reflected after curcumin treatment, accompanied by down-regulation of nuclear factor kappa B (NF-kappa kB) related protein (p65 and pp65), AKT related protein (AKT and pAKT), and NF-kappa B/AKT common related protein MMP-2.	Curcumin	112-120	matrix metallopeptidase 2	Homo sapiens	313-318
33997938-9	2022	CONCLUSIONS: Curcumin could inhibit the viability of ccRCC by down-regulating ADAMTS18 gene methylation though NF-kappa B and AKT signaling pathway.	Curcumin	13-21	ADAM metallopeptidase with thrombospondin type 1 motif 18	Homo sapiens	78-86
32979659-9	2020	We have successfully elucidated that the curcumin analogue CNB001 is a potential EP300 inhibitor with good drug-like characteristics.	Curcumin	41-49	E1A binding protein p300	Homo sapiens	81-86
32515250-11	2020	Additionally, IKKgamma silencing inhibited expression of Bcl-XL, Bcl-2, and cyclin D1.Conclusions: Curcumin enhances LSCC radiosensitivity via NF-KappaB inhibition by suppressing IKKgamma expression.	Curcumin	99-107	cyclin D1	Homo sapiens	76-85
31854220-0	2020	Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cells in vivo by altering MAPK and MMP signalling.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	113-116
31854220-5	2020	The expression of MAPK, NF-kappaB, MMP9, MMP2 and vimentin were confirmed by RT-PCR, immunohistochemistry or western blotting.Results: Administration of curcumin significantly inhibited tumour growth, as the tumour weight decreased from 0.67 g (control) to 0.47 g (15 mg/kg) and 0.35 g (30 mg/kg).	Curcumin	153-161	matrix metallopeptidase 2	Homo sapiens	41-45
31854220-8	2020	Moreover, curcumin attenuated the mRNA transcription and protein expression of MMP2 and MMP9.	Curcumin	10-18	matrix metallopeptidase 2	Homo sapiens	79-83
33561649-10	2021	Overall, the study emphasized that curcumin possesses a strong binding ability with host-specific receptors, furin and ACE2.	Curcumin	35-43	angiotensin converting enzyme 2	Homo sapiens	119-123
32631202-0	2020	Curcumin inhibits proliferation, migration and neointimal formation of vascular smooth muscle via activating miR-22.	Curcumin	0-8	microRNA 22	Rattus norvegicus	109-115
33673981-1	2021	In this study, the electrospun poly(epsilon-caprolactone) (PCL)/Chitosan (CS)/curcumin (CUR) nanofiber was fabricated successfully with curcumin loaded chitosan nano-encapsulated particles (CURCSNPs).	Curcumin	136-144	citrate synthase	Homo sapiens	74-76
32631202-1	2020	Context: Curcumin has antitumor, antioxidative, anti-inflammatory, and anti-proliferative properties.Objective: To investigate the role of miR-22 during curcumin-induced changes in vascular smooth muscle cells (VSMC) and neointima formation in balloon-injured rat abdominal aorta.Materials and methods: Sprague-Dawley rats were randomised to the sham-operated (n = 10), operated control (injured, n = 10), and curcumin treatment (n = 10) groups.	Curcumin	9-17	microRNA 22	Rattus norvegicus	139-145
32631202-6	2020	Curcumin increased the expression of miR-22 (81%, p < 0.05) and decreased the protein expression of SP1 in VSMCs (25%, p < 0.05).	Curcumin	0-8	microRNA 22	Rattus norvegicus	37-43
32631202-7	2020	miR-22 inhibition was found to attenuate the effects of curcumin on VSMC functions.	Curcumin	56-64	microRNA 22	Rattus norvegicus	0-6
32631202-8	2020	Curcumin increased miR-22 (46%, p < 0.01), decreased the SP1 protein (19%, p < 0.05), and inhibited vascular neointimal area (48%, p < 0.01) in vivo.Discussion: The miR-22/SP1 pathway is involved in the protective role of curcumin during arterial balloon injury, but the mechanisms remain unclear.Conclusion: miR-22 is involved in the inhibitory effects of curcumin on VSMCs" proliferation, migration and neointima hyperplasia after arterial balloon injury in rats.	Curcumin	0-8	microRNA 22	Rattus norvegicus	19-25
32631202-8	2020	Curcumin increased miR-22 (46%, p < 0.01), decreased the SP1 protein (19%, p < 0.05), and inhibited vascular neointimal area (48%, p < 0.01) in vivo.Discussion: The miR-22/SP1 pathway is involved in the protective role of curcumin during arterial balloon injury, but the mechanisms remain unclear.Conclusion: miR-22 is involved in the inhibitory effects of curcumin on VSMCs" proliferation, migration and neointima hyperplasia after arterial balloon injury in rats.	Curcumin	0-8	microRNA 22	Rattus norvegicus	165-171
32631202-8	2020	Curcumin increased miR-22 (46%, p < 0.01), decreased the SP1 protein (19%, p < 0.05), and inhibited vascular neointimal area (48%, p < 0.01) in vivo.Discussion: The miR-22/SP1 pathway is involved in the protective role of curcumin during arterial balloon injury, but the mechanisms remain unclear.Conclusion: miR-22 is involved in the inhibitory effects of curcumin on VSMCs" proliferation, migration and neointima hyperplasia after arterial balloon injury in rats.	Curcumin	0-8	microRNA 22	Rattus norvegicus	165-171
32866059-10	2020	In vitro, curcumin reduced the expression of vimentin and alpha-smooth muscle actin in TGF-beta1-induced HK-2 cells.	Curcumin	10-18	transforming growth factor, beta 1	Mus musculus	87-96
32866059-12	2020	In addition, curcumin reduced the expression of TLR4, p-PI3K, p-AKT, p-NF- kappaB and p-IkappaBalpha in both LPS- and TGF-beta1-induced HK-2 cells.	Curcumin	13-21	transforming growth factor, beta 1	Mus musculus	118-127
33955148-0	2021	Radiosensitizing effects of curcumin alone or combined with GLUT1 siRNA on laryngeal carcinoma cells through AMPK pathway-induced autophagy.	Curcumin	28-36	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	109-113
33459817-0	2021	Addressing the potential role of curcumin in the prevention of COVID-19 by targeting the Nsp9 replicase protein through molecular docking.	Curcumin	33-41	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	89-93
33459817-5	2021	The in silico molecular docking of curcumin with the replicase enzyme gave insights into the preventive measures against the virus as curcumin showed multiple interactions with Nsp9 replicase.	Curcumin	35-43	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	177-181
33459817-5	2021	The in silico molecular docking of curcumin with the replicase enzyme gave insights into the preventive measures against the virus as curcumin showed multiple interactions with Nsp9 replicase.	Curcumin	134-142	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	177-181
33926561-0	2021	Curcumin-primed human BMSC-derived extracellular vesicles reverse IL-1beta-induced catabolic responses of OA chondrocytes by upregulating miR-126-3p.	Curcumin	0-8	microRNA 1263	Homo sapiens	138-148
33377585-8	2021	The curcumin-mediated protection against IL-1beta induced apoptosis was abolished when cells were treated with the autophagy inhibitor 3-MA or transfected with Beclin-1 small interfering RNA.	Curcumin	4-12	beclin 1	Rattus norvegicus	160-168
33248620-9	2020	Furthermore, curcumin ameliorated AFB1-induced decrease in the Abcb1 mRNA expression, P-glycoprotein (P-gp) level, and ATPase activities.	Curcumin	13-21	ATP binding cassette subfamily B member 1	Gallus gallus	63-68
32761362-7	2020	Curcumin increased expression levels of the pro-survival B cell lymphoma extra-large (Bcl-xL) gene and two genes involved in mitochondrial function, peroxisome proliferative-activated receptor-gamma co-activator 1alpha (PGC-1alpha) and mitochondrial transcription factor A (TFAM), in the hippocampus of BDL rats compared with the vehicle-treated sham or BDL rats, while it decreased the pro-apoptotic Bcl-2-associated X protein (Bax) gene expression level.	Curcumin	0-8	Bcl2-like 1	Rattus norvegicus	86-92
32761362-7	2020	Curcumin increased expression levels of the pro-survival B cell lymphoma extra-large (Bcl-xL) gene and two genes involved in mitochondrial function, peroxisome proliferative-activated receptor-gamma co-activator 1alpha (PGC-1alpha) and mitochondrial transcription factor A (TFAM), in the hippocampus of BDL rats compared with the vehicle-treated sham or BDL rats, while it decreased the pro-apoptotic Bcl-2-associated X protein (Bax) gene expression level.	Curcumin	0-8	transcription factor A, mitochondrial	Rattus norvegicus	274-278
32761362-9	2020	Furthermore, curcumin reduced the mRNA level of Bax, while it increased Bcl-2 and TFAM mRNA levels.	Curcumin	13-21	transcription factor A, mitochondrial	Rattus norvegicus	82-86
33247374-6	2022	In addition, we showed that the phosphorylation levels of ERK1/2, JNK, and P38 were upregulated in apoptotic hUC-MSCs, while curcumin increased the phosphorylation of ERK1/2 but did not activate JNK or P38, and these effects were reversed by the p42/44 antagonist U0126.	Curcumin	125-133	mitogen activated protein kinase 3	Rattus norvegicus	167-173
33247374-8	2022	These data confirmed that curcumin suppressed hUC-MSC apoptosis through the ERK1/2 signaling pathway and that combined curcumin and hUC-MSC treatment improved motor function in rats after SCI.	Curcumin	26-34	mitogen activated protein kinase 3	Rattus norvegicus	76-82
33473285-5	2021	Curcumin could downregulate mRNA levels of SREBP2, SP-1 and SCAP, but it did not simultaneously downregulate the expression of precursor SREBP-2 (pSREBP-2) and SCAP.	Curcumin	0-8	SREBF chaperone	Homo sapiens	60-64
33755170-0	2021	Curcumin Enhances the Radiosensitivity of Human Urethral Scar Fibroblasts by Apoptosis, Cell Cycle Arrest and Downregulation of Smad4 via Autophagy.	Curcumin	0-8	SMAD family member 4	Homo sapiens	128-133
33755170-8	2021	In addition, curcumin combined with radiation inhibited the synthesis of collagen I and collagen III through Smad4 pathway, with possible involvement of autophagy.	Curcumin	13-21	SMAD family member 4	Homo sapiens	109-114
33755170-9	2021	These results suggest that curcumin could be a radiosensitizer of HUSFs, inhibit the proliferation of HUSFs and suppress fibrosis by downregulation of Smad4 via autophagy.	Curcumin	27-35	SMAD family member 4	Homo sapiens	151-156
33875681-0	2021	Curcumin activates Nrf2 through PKCdelta-mediated p62 phosphorylation at Ser351.	Curcumin	0-8	protein kinase C delta	Homo sapiens	32-40
33875681-6	2021	Among the kinases involved in p62 phosphorylation at S351, PKCdelta was activated in curcumin-treated cells.	Curcumin	85-93	protein kinase C delta	Homo sapiens	59-67
33875681-8	2021	Together, these results suggest that PKCdelta is mainly involved in curcumin-induced p62 phosphorylation and Nrf2 activation.	Curcumin	68-76	protein kinase C delta	Homo sapiens	37-45
33875681-9	2021	Accordingly, we demonstrate for the first time that curcumin activates Nrf2 through PKCdelta-mediated p62 phosphorylation at S351.	Curcumin	52-60	protein kinase C delta	Homo sapiens	84-92
33923718-6	2021	In the present study, hydroxyapatite was subjected to hydrophobic surface modifications for curcumin loading (Cur-SHAP).	Curcumin	92-100	shroom family member 4	Homo sapiens	114-118
32738342-0	2020	Curcumin reduces methionine adenosyltransferase 2B expression by interrupting phosphorylation of p38 MAPK in hepatic stellate cells.	Curcumin	0-8	mitogen-activated protein kinase 14	Mus musculus	97-105
33354908-9	2021	Furthermore, mitochondrial dysfunction was ameliorated and the LC3B/LC3A ratio and Beclin-1 expression were increased in curcumin-treated rats.	Curcumin	121-129	beclin 1	Rattus norvegicus	83-91
32738342-8	2020	The effect of curcumin on MAT2B was through its interruption of p38 MAPK signaling pathway.	Curcumin	14-22	mitogen-activated protein kinase 14	Mus musculus	64-72
33204708-14	2020	In addition, curcumin downregulated the expression of Bax, Caspase-3, p62, PI3K, p-AKT, and p-mTOR proteins and upregulated the Bcl-2, beclin1, LC3, Nrf2, and HO-1 levels in this animal model.	Curcumin	13-21	caspase 3	Rattus norvegicus	59-68
33204708-14	2020	In addition, curcumin downregulated the expression of Bax, Caspase-3, p62, PI3K, p-AKT, and p-mTOR proteins and upregulated the Bcl-2, beclin1, LC3, Nrf2, and HO-1 levels in this animal model.	Curcumin	13-21	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	70-73
33204708-14	2020	In addition, curcumin downregulated the expression of Bax, Caspase-3, p62, PI3K, p-AKT, and p-mTOR proteins and upregulated the Bcl-2, beclin1, LC3, Nrf2, and HO-1 levels in this animal model.	Curcumin	13-21	beclin 1	Rattus norvegicus	135-142
33204708-14	2020	In addition, curcumin downregulated the expression of Bax, Caspase-3, p62, PI3K, p-AKT, and p-mTOR proteins and upregulated the Bcl-2, beclin1, LC3, Nrf2, and HO-1 levels in this animal model.	Curcumin	13-21	annexin A3	Rattus norvegicus	144-147
33923718-10	2021	In summary, we successfully synthesized hydrophobic surface modification hydroxyapatite for curcumin loading (Cur-SHAP) and drug delivery via the IM route.	Curcumin	92-100	shroom family member 4	Homo sapiens	114-118
33373686-0	2021	PARP inhibitor Veliparib (ABT-888) enhances the anti-angiogenic potentiality of Curcumin through deregulation of NECTIN-4 in oral cancer: Role of nitric oxide (NO).	Curcumin	80-88	collagen type XI alpha 2 chain	Homo sapiens	0-4
32961025-0	2020	Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1-Foxo1 and PI3K-Akt signalling pathways.	Curcumin	0-8	forkhead box O1	Rattus norvegicus	97-102
32961025-9	2020	Curcumin treatment also enhanced phosphorylation of Akt and inhibited acetylation of Foxo1.	Curcumin	0-8	forkhead box O1	Rattus norvegicus	85-90
32961025-10	2020	These results strongly suggest that apoptosis was increased in the heart of diabetic rats, and curcumin played a role in diabetic cardiomyopathy treatment by modulating the Sirt1-Foxo1 and PI3K-Akt pathways.	Curcumin	95-103	forkhead box O1	Rattus norvegicus	179-184
33184809-9	2021	Both the molecules curcumin and catechin get bound directly to receptors binding domain of S-protein and ACE-2 receptors of host cell, due to which these molecules inhibit the entry of virus in host cell i. e. animal survives from being infected.	Curcumin	19-27	angiotensin converting enzyme 2	Homo sapiens	105-110
32735936-0	2020	Curcumin induces expression of 15-hydroxyprostaglandin dehydrogenase in gastric mucosal cells and mouse stomach in vivo: AP-1 as a potential target.	Curcumin	0-8	hydroxyprostaglandin dehydrogenase 15 (NAD)	Mus musculus	31-68
32735936-0	2020	Curcumin induces expression of 15-hydroxyprostaglandin dehydrogenase in gastric mucosal cells and mouse stomach in vivo: AP-1 as a potential target.	Curcumin	0-8	jun proto-oncogene	Mus musculus	121-125
32735936-2	2020	In the present study, we found that curcumin, a yellow coloring agent present in the rhizome of Curcuma longa Linn (Zingiberaceae), induced expression of 15-PGDH at the both transcriptional and translational levels in normal rat gastric mucosal cells.	Curcumin	36-44	hydroxyprostaglandin dehydrogenase 15 (NAD)	Mus musculus	154-161
33849570-11	2021	CONCLUSION: Curcumin-functionalised poly(lactic-co-glycolic acid)-dextran micelles are novel nanostructures with an intrinsic antibacterial activity tested against two Pseudomonas spp.	Curcumin	12-20	histocompatibility minor 13	Homo sapiens	180-183
33732362-9	2021	In addition, the results demonstrated that curcumin inhibited the TLR4/NF-kappaB signaling pathway and the expression of inflammatory factors, including IL-6, IL-1beta, prostaglandin E2 and cyclooxygenase-2, in mouse xenograft tumors.	Curcumin	43-51	prostaglandin-endoperoxide synthase 2	Mus musculus	190-206
32735936-3	2020	By using deletion constructs of 15-PGDH promoter, we were able to demonstrate that activator protein-1 (AP-1) is the principal transcription factor responsible for regulating curcumin-induced 15-PGDH expression.	Curcumin	175-183	15-hydroxyprostaglandin dehydrogenase	Rattus norvegicus	32-39
32735936-3	2020	By using deletion constructs of 15-PGDH promoter, we were able to demonstrate that activator protein-1 (AP-1) is the principal transcription factor responsible for regulating curcumin-induced 15-PGDH expression.	Curcumin	175-183	jun proto-oncogene	Mus musculus	83-102
32735936-3	2020	By using deletion constructs of 15-PGDH promoter, we were able to demonstrate that activator protein-1 (AP-1) is the principal transcription factor responsible for regulating curcumin-induced 15-PGDH expression.	Curcumin	175-183	jun proto-oncogene	Mus musculus	104-108
33850236-0	2021	Author Correction: Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies.	Curcumin	32-40	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	55-56
33850236-0	2021	Author Correction: Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies.	Curcumin	32-40	angiotensin converting enzyme 2	Homo sapiens	82-86
32735936-3	2020	By using deletion constructs of 15-PGDH promoter, we were able to demonstrate that activator protein-1 (AP-1) is the principal transcription factor responsible for regulating curcumin-induced 15-PGDH expression.	Curcumin	175-183	15-hydroxyprostaglandin dehydrogenase	Rattus norvegicus	192-199
32735936-4	2020	Curcumin enhanced the expression of c-Jun and c-Fos, which are functional subunits of AP-1, in the nuclear fraction of cells.	Curcumin	0-8	jun proto-oncogene	Mus musculus	36-41
33732362-10	2021	Furthermore, curcumin suppressed the secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte-colony stimulating factor (G-CSF), which are essential factors for MDSCs modulation, in tumor tissues.	Curcumin	13-21	colony stimulating factor 3 (granulocyte)	Mus musculus	112-149
32735936-4	2020	Curcumin enhanced the expression of c-Jun and c-Fos, which are functional subunits of AP-1, in the nuclear fraction of cells.	Curcumin	0-8	jun proto-oncogene	Mus musculus	86-90
32735936-5	2020	Silencing of c-Jun suppressed curcumin-induced expression of 15-PGDH.	Curcumin	30-38	jun proto-oncogene	Mus musculus	13-18
33918207-7	2021	Numerous in vitro and in vivo studies show that curcumin may interact with many cellular targets (NF-kappaB, JAKs/STATs, MAPKs, TNF-gamma, IL-6, PPARgamma, and TRPV1) and effectively reduce the progression of IBD with promising results.	Curcumin	48-56	transient receptor potential cation channel subfamily V member 1	Homo sapiens	160-165
33548579-9	2021	Molecular analysis revealed that curcumin exerted protective effects via suppressing neuroinflammation induced by microglial activation, regulating the triggering receptor expressed on myeloid cells 2 (TREM2)/toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-kappaB) pathway, alleviating apoptosis, and reducing nod-like receptor protein 3 (NLRP3)-dependent pyroptosis.	Curcumin	33-41	triggering receptor expressed on myeloid cells 2	Rattus norvegicus	152-200
32735936-5	2020	Silencing of c-Jun suppressed curcumin-induced expression of 15-PGDH.	Curcumin	30-38	15-hydroxyprostaglandin dehydrogenase	Rattus norvegicus	61-68
33548579-9	2021	Molecular analysis revealed that curcumin exerted protective effects via suppressing neuroinflammation induced by microglial activation, regulating the triggering receptor expressed on myeloid cells 2 (TREM2)/toll-like receptor 4 (TLR4)/nuclear factor-kappaB (NF-kappaB) pathway, alleviating apoptosis, and reducing nod-like receptor protein 3 (NLRP3)-dependent pyroptosis.	Curcumin	33-41	triggering receptor expressed on myeloid cells 2	Rattus norvegicus	202-207
32735936-6	2020	Moreover, the chromatin immuoprecipitation assay revealed curcumin-induced binding of c-Jun to the AP-1 consensus sequence present in the 15-PGDH promoter.	Curcumin	58-66	jun proto-oncogene	Mus musculus	86-91
33732362-10	2021	Furthermore, curcumin suppressed the secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte-colony stimulating factor (G-CSF), which are essential factors for MDSCs modulation, in tumor tissues.	Curcumin	13-21	colony stimulating factor 3 (granulocyte)	Mus musculus	151-156
32735936-6	2020	Moreover, the chromatin immuoprecipitation assay revealed curcumin-induced binding of c-Jun to the AP-1 consensus sequence present in the 15-PGDH promoter.	Curcumin	58-66	jun proto-oncogene	Mus musculus	99-103
32735936-6	2020	Moreover, the chromatin immuoprecipitation assay revealed curcumin-induced binding of c-Jun to the AP-1 consensus sequence present in the 15-PGDH promoter.	Curcumin	58-66	15-hydroxyprostaglandin dehydrogenase	Rattus norvegicus	138-145
32735936-7	2020	Curcumin increased phosphorylation of ERK1/2 and JNK, and pharmacologic inhibition of these kinases abrogated the curcumin-induced phosphorylation of c-Jun and 15-PGDH expression.	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	38-44
32735936-7	2020	Curcumin increased phosphorylation of ERK1/2 and JNK, and pharmacologic inhibition of these kinases abrogated the curcumin-induced phosphorylation of c-Jun and 15-PGDH expression.	Curcumin	0-8	jun proto-oncogene	Mus musculus	150-155
32735936-7	2020	Curcumin increased phosphorylation of ERK1/2 and JNK, and pharmacologic inhibition of these kinases abrogated the curcumin-induced phosphorylation of c-Jun and 15-PGDH expression.	Curcumin	0-8	15-hydroxyprostaglandin dehydrogenase	Rattus norvegicus	160-167
32735936-7	2020	Curcumin increased phosphorylation of ERK1/2 and JNK, and pharmacologic inhibition of these kinases abrogated the curcumin-induced phosphorylation of c-Jun and 15-PGDH expression.	Curcumin	114-122	mitogen activated protein kinase 3	Rattus norvegicus	38-44
33655321-6	2021	Moreover, curcumin reduced the PM2.5-induced expression and production of inflammatory factors, and induced the expression of the anti-inflammatory factors, interleukin (IL)-5 and IL-13.	Curcumin	10-18	interleukin 5	Homo sapiens	157-175
33732362-11	2021	Additionally, curcumin was revealed to inhibit angiogenesis, which was demonstrated by the downregulation of the expression levels of vascular endothelial growth factor, CD31 and alpha-smooth muscle actin in western blotting, immunohistochemistry and immunofluorescence experiments.	Curcumin	14-22	platelet/endothelial cell adhesion molecule 1	Mus musculus	170-174
32735936-7	2020	Curcumin increased phosphorylation of ERK1/2 and JNK, and pharmacologic inhibition of these kinases abrogated the curcumin-induced phosphorylation of c-Jun and 15-PGDH expression.	Curcumin	114-122	jun proto-oncogene	Mus musculus	150-155
32735936-7	2020	Curcumin increased phosphorylation of ERK1/2 and JNK, and pharmacologic inhibition of these kinases abrogated the curcumin-induced phosphorylation of c-Jun and 15-PGDH expression.	Curcumin	114-122	15-hydroxyprostaglandin dehydrogenase	Rattus norvegicus	160-167
33738123-0	2021	Therapeutic effects of EGF-modified curcumin/chitosan nano-spray on wound healing.	Curcumin	36-44	epidermal growth factor like 1	Rattus norvegicus	23-26
32735936-9	2020	Curcumin restored the expression of 15-PGDH which is down-regulated by Helicobactor pylori through suppression of DNA methyltransferase 1.	Curcumin	0-8	15-hydroxyprostaglandin dehydrogenase	Rattus norvegicus	36-43
32735936-10	2020	In addition, oral administration of curcumin increased the expression of 15-PGDH and its regulators such as p-ERK1/2, p-JNK, and c-Jun in the mouse stomach.	Curcumin	36-44	hydroxyprostaglandin dehydrogenase 15 (NAD)	Mus musculus	73-80
32735936-10	2020	In addition, oral administration of curcumin increased the expression of 15-PGDH and its regulators such as p-ERK1/2, p-JNK, and c-Jun in the mouse stomach.	Curcumin	36-44	mitogen-activated protein kinase 3	Mus musculus	110-116
32735936-10	2020	In addition, oral administration of curcumin increased the expression of 15-PGDH and its regulators such as p-ERK1/2, p-JNK, and c-Jun in the mouse stomach.	Curcumin	36-44	jun proto-oncogene	Mus musculus	129-134
32735936-11	2020	Taken together, these findings suggest that curcumin-induced upregulation of 15-PGDH may contribute to chemopreventive effects of this phytochemical on inflammation-associated gastric carcinogenesis.	Curcumin	44-52	hydroxyprostaglandin dehydrogenase 15 (NAD)	Mus musculus	77-84
33063743-0	2021	Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice.	Curcumin	34-42	prostaglandin-endoperoxide synthase 2	Mus musculus	119-135
33063743-11	2021	Moreover, the beneficial effects of meloxicam and curcumin-co-loaded LCN could be explained by the anti-inflammatory properties of these drugs through cortical COX-2 downregulation.	Curcumin	50-58	prostaglandin-endoperoxide synthase 2	Mus musculus	160-165
33063743-12	2021	Our study suggests that the neuroprotective potential of meloxicam and curcumin co-nanoencapsulation is associated with cortical COX-2 modulation.	Curcumin	71-79	prostaglandin-endoperoxide synthase 2	Mus musculus	129-134
33649826-6	2021	Western blotting results indicated that curcumin dose-dependently suppressed the phosphorylation of AKT, PRAS40, 4E-BP1, P70S6K, RAF-1 and p27 in AML cell lines (ML-2 and OCI-AML5).	Curcumin	40-48	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	129-134
32835867-0	2020	In vitro and in vivo studies on potentiation of curcumin-induced lysosomal-dependent apoptosis upon silencing of cathepsin C in colorectal cancer cells.	Curcumin	48-56	cathepsin C	Mus musculus	113-124
33649826-7	2021	It was also demonstrated that curcumin regulated the cell cycle- and apoptosis-related proteins (cyclin D1, p21, Bcl2, cleaved-caspase-3 and cleaved-PARP), leading to cell cycle arrest and apoptosis in both ML-2 and OCI-AML5 cells.	Curcumin	30-38	cyclin D1	Homo sapiens	97-106
32835867-2	2020	Herein, we report that cathepsin C (CTSC) silencing upregulates the anticancer potential of curcumin in colorectal cancer cells (CRCs) both in vitro and in athymic mice xenografts.	Curcumin	92-100	cathepsin C	Mus musculus	23-34
33738123-4	2021	We prepared curcumin-loaded chitosan nanoparticles modified with epidermal growth factor (EGF) to develop an aqueous EGF-modified spray (EGF@CCN) for the treatment of dermal wounds.	Curcumin	12-20	epidermal growth factor like 1	Rattus norvegicus	65-88
32835867-2	2020	Herein, we report that cathepsin C (CTSC) silencing upregulates the anticancer potential of curcumin in colorectal cancer cells (CRCs) both in vitro and in athymic mice xenografts.	Curcumin	92-100	cathepsin C	Mus musculus	36-40
32835867-3	2020	Curcumin treatment enhances CTSC level in CRCs; however, CTSC silencing with subsequent curcumin treatment (sequential treatment) induces ER stress and autophagic dysregulation accompanied by lysosomal permeabilization and ROS generation.	Curcumin	0-8	cathepsin C	Mus musculus	28-32
33649826-7	2021	It was also demonstrated that curcumin regulated the cell cycle- and apoptosis-related proteins (cyclin D1, p21, Bcl2, cleaved-caspase-3 and cleaved-PARP), leading to cell cycle arrest and apoptosis in both ML-2 and OCI-AML5 cells.	Curcumin	30-38	collagen type XI alpha 2 chain	Homo sapiens	149-153
33738123-4	2021	We prepared curcumin-loaded chitosan nanoparticles modified with epidermal growth factor (EGF) to develop an aqueous EGF-modified spray (EGF@CCN) for the treatment of dermal wounds.	Curcumin	12-20	epidermal growth factor like 1	Rattus norvegicus	90-93
33738123-4	2021	We prepared curcumin-loaded chitosan nanoparticles modified with epidermal growth factor (EGF) to develop an aqueous EGF-modified spray (EGF@CCN) for the treatment of dermal wounds.	Curcumin	12-20	epidermal growth factor like 1	Rattus norvegicus	117-120
33502392-6	2021	Furthermore, due to the lower critical solution temperature properties of Pluronic  L35, the PMs exhibit temperature responsiveness at 37.0  C. In vitro cytotoxicity assays were also performed to determine the potency of CCM-PM formulations, and a 1.8-fold decrease in IC50 values was observed between the CCM-PMs/[Ch][Hex] and CCM-PMs/[Ch]Cl formulations for PC3 cells.	Curcumin	221-224	hematopoietically expressed homeobox	Homo sapiens	319-322
33502392-7	2021	The lower IC50 value for the [Ch][Hex] version corresponded to a greater potency compared to the [Ch]Cl version, since a lower concentration of CCM was required to achieve the same therapeutic effect.	Curcumin	144-147	hematopoietically expressed homeobox	Homo sapiens	34-37
32338107-12	2020	We verified the direct regulation of PTEN by miR-181a in cultured human embryonic kidney 293T cells.Conclusions: We showed the involvement of miR-181a/PTEN axis in the renoprotective effect of curcumin against cisplatin-induced AKI, and provide new evidence on the ability of curcumin to alleviate cisplatin-induced nephrotoxicity.	Curcumin	276-284	microRNA 181a-2	Mus musculus	142-150
33738123-4	2021	We prepared curcumin-loaded chitosan nanoparticles modified with epidermal growth factor (EGF) to develop an aqueous EGF-modified spray (EGF@CCN) for the treatment of dermal wounds.	Curcumin	12-20	epidermal growth factor like 1	Rattus norvegicus	117-120
32694760-11	2021	Together, curcumin promotes the expression of HGF in colonic fibroblasts and macrophages by activating PPARgamma and CREB via an induction of 15d-PGJ2, and the HGF enters the lungs giving rise to an anti-PF effect.	Curcumin	10-18	peroxisome proliferator activated receptor gamma	Mus musculus	103-112
33618616-8	2021	The protein kinase C theta (PKC-theta) was associated with the protective function of curcumin in the OGD/R cell model.	Curcumin	86-94	protein kinase C, theta	Rattus norvegicus	4-37
33730297-4	2021	Blood gas analysis, ELISA, and weighing of wet weight/dry weight (W/D) ratio indicated that Curcumin diminished mPAP and RVSP levels, W/D ratio, thrombus volume, and inflammatory factors in the lungs of APE rats.	Curcumin	92-100	phospholipid phosphatase 1	Mus musculus	112-116
34014157-15	2021	Nevertheless, curcumin could reverse the HSP65-induced CCL2 upregulation through restraining JAK2/AKT/STAT3 pathway.	Curcumin	14-22	Janus kinase 2	Homo sapiens	93-97
34014157-16	2021	The inhibitory effect of curcumin on the JAK2/AKT/STAT3 pathway was even more obvious than that of methotrexate and tofacitinib.	Curcumin	25-33	Janus kinase 2	Homo sapiens	41-45
34014157-17	2021	CONCLUSIONS: Curcumin alleviated inflammation in TAK by downregulating CCL2 overexpression in AAFs through inhibiting the JAK2/AKT/STAT3 signalling pathway.	Curcumin	13-21	Janus kinase 2	Homo sapiens	122-126
33617879-5	2021	Here, we show that functionalization of the 4-arylidene position of the fluorescent curcumin scaffold with an aryl nitrogen mustard provides a stable Hck inhibitor (Kd = 50 +- 10 nM).	Curcumin	84-92	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	150-153
33959308-9	2021	Additionally, 10 microM curcumin remarkably enhanced mature adipocyte mitochondrial respiratory function, specifically, accelerating basic mitochondrial respiration, ATP production and uncoupling capacity via the regulation of peroxisome proliferator-activated receptor gamma (PPARgamma) (p < 0.01).	Curcumin	24-32	peroxisome proliferator activated receptor gamma	Mus musculus	227-275
33959308-9	2021	Additionally, 10 microM curcumin remarkably enhanced mature adipocyte mitochondrial respiratory function, specifically, accelerating basic mitochondrial respiration, ATP production and uncoupling capacity via the regulation of peroxisome proliferator-activated receptor gamma (PPARgamma) (p < 0.01).	Curcumin	24-32	peroxisome proliferator activated receptor gamma	Mus musculus	277-286
33959308-11	2021	Moreover, curcumin markedly increased the mRNA and protein expressions of mitochondrial uncoupling protein 1 (UCP1), PPARgamma, peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) and PR domain protein 16 (PRDM16) in vivo and in vitro.	Curcumin	10-18	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	110-114
33959308-11	2021	Moreover, curcumin markedly increased the mRNA and protein expressions of mitochondrial uncoupling protein 1 (UCP1), PPARgamma, peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) and PR domain protein 16 (PRDM16) in vivo and in vitro.	Curcumin	10-18	peroxisome proliferator activated receptor gamma	Mus musculus	117-126
33959308-11	2021	Moreover, curcumin markedly increased the mRNA and protein expressions of mitochondrial uncoupling protein 1 (UCP1), PPARgamma, peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) and PR domain protein 16 (PRDM16) in vivo and in vitro.	Curcumin	10-18	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	128-195
33959308-11	2021	Moreover, curcumin markedly increased the mRNA and protein expressions of mitochondrial uncoupling protein 1 (UCP1), PPARgamma, peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) and PR domain protein 16 (PRDM16) in vivo and in vitro.	Curcumin	10-18	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	197-207
33617879-6	2021	The mustard curcumin derivative preferentially interacts with the inactive conformation of Hck, similar to type-II kinase inhibitors that are less promiscuous.	Curcumin	12-20	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	91-94
33959308-12	2021	Collectively, the results demonstrate that curcumin promotes the adipogenic differentiation of preadipocytes and mitochondrial oxygen consumption in 3T3-L1 mature adipocytes by regulating UCP1, PRDM16, PPARgamma and PGC-1alpha expression.	Curcumin	43-51	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	188-192
33959308-12	2021	Collectively, the results demonstrate that curcumin promotes the adipogenic differentiation of preadipocytes and mitochondrial oxygen consumption in 3T3-L1 mature adipocytes by regulating UCP1, PRDM16, PPARgamma and PGC-1alpha expression.	Curcumin	43-51	peroxisome proliferator activated receptor gamma	Mus musculus	202-211
33551001-0	2021	Curcumin induces mitochondrial biogenesis by increasing cAMP levels via PDE4A inhibition in skeletal muscle.	Curcumin	0-8	phosphodiesterase 4A	Rattus norvegicus	72-77
33959308-12	2021	Collectively, the results demonstrate that curcumin promotes the adipogenic differentiation of preadipocytes and mitochondrial oxygen consumption in 3T3-L1 mature adipocytes by regulating UCP1, PRDM16, PPARgamma and PGC-1alpha expression.	Curcumin	43-51	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	216-226
32694760-8	2021	In CCD-18Co cells and RAW264.7 cells, curcumin dose-dependently activated PPARgamma and CREB, whereas PPARgamma antagonist GW9662 (1 muM) or cAMP response element (CREB) inhibitor KG-501 (10 muM) significantly decreased the boosting effect of curcumin on HGF expression.	Curcumin	38-46	peroxisome proliferator activated receptor gamma	Mus musculus	74-83
33574907-9	2021	Based on the results of the present study, CCM may exert its anti-tumor effects in U87 cells by inhibiting the HSP60/TLR-4/MYD88/NF-kappaB pathway and inducing tumor cell apoptosis.	Curcumin	43-46	MYD88 innate immune signal transduction adaptor	Homo sapiens	123-128
33551001-7	2021	Results: Curcumin administration increased COX-IV protein expression, and CS and complex I activity, consistent with the induction of mitochondrial biogenesis by curcumin.	Curcumin	9-17	citrate synthase	Rattus norvegicus	74-76
33551001-10	2021	In addition, exercise increased the phosphorylation of PDE4A, whereas curcumin treatment strongly inhibited PDE4A phosphorylation regardless of exercise.	Curcumin	70-78	phosphodiesterase 4A	Rattus norvegicus	108-113
33551001-13	2021	Conclusion: The present results suggest that curcumin increases cAMP levels via inhibition of PDE4A phosphorylation, which induces mitochondrial biogenesis through a cAMP/PKA/AMPK signalling pathway.	Curcumin	45-53	phosphodiesterase 4A	Rattus norvegicus	94-99
32141392-0	2021	A study on the effects of inhibition mechanism of curcumin, quercetin, and resveratrol on human glutathione reductase through in vitro and in silico approaches.	Curcumin	50-58	glutathione-disulfide reductase	Homo sapiens	96-117
33376508-8	2021	Curcumin pre-treatment decreased blood urea nitrogen and serum creatinine, urinary kidney injury molecule-1, and neutrophil gelatinase-associated lipocalin levels compared with the dry-heat control group.	Curcumin	0-8	lipocalin 2	Rattus norvegicus	113-155
33376508-9	2021	Curcumin was also revealed to downregulate c-Jun N-terminal kinases (JNK), cytochrome c, caspase-3 and caspase-9 expression upon treatment with 100 and 200 mg/kg curcumin, which may result in inhibition of the mitochondrial apoptotic pathway in renal cells.	Curcumin	0-8	caspase 3	Rattus norvegicus	89-98
33376508-9	2021	Curcumin was also revealed to downregulate c-Jun N-terminal kinases (JNK), cytochrome c, caspase-3 and caspase-9 expression upon treatment with 100 and 200 mg/kg curcumin, which may result in inhibition of the mitochondrial apoptotic pathway in renal cells.	Curcumin	162-170	caspase 3	Rattus norvegicus	89-98
33655086-8	2021	Second, curcumin protects from lethal pneumonia and ARDS via targeting NF-kappaB, inflammasome, IL-6 trans signal, and HMGB1 pathways.	Curcumin	8-16	high mobility group box 1	Homo sapiens	119-124
33464911-6	2021	AF4 analysis further showed that the released curcumin was subsequently solubilized by albumin.	Curcumin	46-54	immunoglobulin kappa variable 4-80	Mus musculus	0-3
33464911-8	2021	Intravenously administered curcumin-loaded, Cy7-labeled mPEG5kDa-b-p(HPMA-Bz)17.1kDa micelles in mice at 50 mg curcumin/kg showed a long circulation half-life for the micelles (t1/2 = 42 h), in line with the AF4 results.	Curcumin	27-35	immunoglobulin kappa variable 4-80	Mus musculus	208-211
33220404-0	2021	Curcumin steers THP-1 cells under LPS and mTORC1 challenges toward phenotypically resting, low cytokine-producing macrophages.	Curcumin	0-8	CREB regulated transcription coactivator 1	Mus musculus	42-48
32985484-4	2021	Our results revealed that solid lipid nanoparticle loading with curcumin and dexanabinol increased the mRNA and protein expression levels of the mature neuronal markers neuronal nuclei, mitogen-activated protein 2, and neuron-specific beta-tubulin III, promoted the release of dopamine and norepinephrine, and increased the mRNA expression of CBR1 and the downstream genes Rasgef1c and Egr1, and simultaneously improved rat locomotor function.	Curcumin	64-72	cannabinoid receptor 1 (brain)	Mus musculus	343-347
33617879-0	2021	Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative.	Curcumin	91-99	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	45-70
33617879-0	2021	Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative.	Curcumin	91-99	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-75
33220404-2	2021	The present study investigated the regulatory properties of food-derived mTORC1 modulators, curcumin and piperine, toward the polarization of stimulated macrophages and the differentiation of monocytes at two mTORC1 activity levels (baseline and elevated).	Curcumin	92-100	CREB regulated transcription coactivator 1	Mus musculus	73-79
33220404-4	2021	Curcumin or its combination with piperine, but not piperine alone, suppressed mTORC1 kinase activity, curtailed lipopolysaccharide-mediated inflammatory response of THP-1 macrophages, and repressed macrophage activation by inhibiting signaling pathways involved in M1 (mTORC1) and M2 (mTORC2, CREB) polarization.	Curcumin	0-8	CREB regulated transcription coactivator 1	Mus musculus	78-84
33383083-8	2021	Color changes of curcumin loaded CS/PEO nanofiber film was evaluated on chicken breast package at 4  C. The color of nanofiber film changed from bright yellow to reddish color which provided an opportunity to detect color changes by even the naked eyes of the untrained consumer.	Curcumin	17-25	citrate synthase	Gallus gallus	33-35
33220404-4	2021	Curcumin or its combination with piperine, but not piperine alone, suppressed mTORC1 kinase activity, curtailed lipopolysaccharide-mediated inflammatory response of THP-1 macrophages, and repressed macrophage activation by inhibiting signaling pathways involved in M1 (mTORC1) and M2 (mTORC2, CREB) polarization.	Curcumin	0-8	CREB regulated transcription coactivator 1	Mus musculus	269-275
33220404-4	2021	Curcumin or its combination with piperine, but not piperine alone, suppressed mTORC1 kinase activity, curtailed lipopolysaccharide-mediated inflammatory response of THP-1 macrophages, and repressed macrophage activation by inhibiting signaling pathways involved in M1 (mTORC1) and M2 (mTORC2, CREB) polarization.	Curcumin	0-8	CREB regulated transcription coactivator 2	Mus musculus	285-291
33629331-0	2021	Effects of curcumin administration on Nesfatin-1 levels in blood, brain and fat tissues of diabetic rats.	Curcumin	11-19	nucleobindin 2	Rattus norvegicus	38-48
33645034-12	2021	Meanwhile, curcumin could increase the positive expression of occludin, claudin and ZO-1(P<0.05 or P<0.01), repair intestinal barrier function, downregulate the protein expression of IL-6, p-STAT3, vimentin and N-cadherin in jejunum tissues(P<0.05 or P<0.01), and upregulate the protein expression of E-cadherin(P<0.05).	Curcumin	11-19	occludin	Rattus norvegicus	62-70
33629331-1	2021	OBJECTIVE: We evaluated the efficacy of curcumin administration on blood glucose levels and its relationship with nesfatin-1 levels in blood brain and adipose tissue of streptozotocin-induced diabetic rats.	Curcumin	40-48	nucleobindin 2	Rattus norvegicus	114-124
33629331-10	2021	Thus, considering the crucial role of nesfatin-1 in regulation of glucose metabolism, it is logical to expect an interactive relationship between curcumin and nesfatin-1.	Curcumin	146-154	nucleobindin 2	Rattus norvegicus	38-48
33645034-12	2021	Meanwhile, curcumin could increase the positive expression of occludin, claudin and ZO-1(P<0.05 or P<0.01), repair intestinal barrier function, downregulate the protein expression of IL-6, p-STAT3, vimentin and N-cadherin in jejunum tissues(P<0.05 or P<0.01), and upregulate the protein expression of E-cadherin(P<0.05).	Curcumin	11-19	vimentin	Rattus norvegicus	198-206
33629331-10	2021	Thus, considering the crucial role of nesfatin-1 in regulation of glucose metabolism, it is logical to expect an interactive relationship between curcumin and nesfatin-1.	Curcumin	146-154	nucleobindin 2	Rattus norvegicus	159-169
33479401-0	2021	Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies.	Curcumin	13-21	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	36-37
33494543-2	2021	The curcumin-loaded rhamnolipid liposomes (Cur-RL-Lips) were fabricated from rhamnolipid and phospholipids, and then chitosan (CS) covered the surface of Cur-RL-Lips by electrostatic interaction to form CS-coated Cur-RL-Lips.	Curcumin	4-12	citrate synthase	Homo sapiens	127-129
33494543-2	2021	The curcumin-loaded rhamnolipid liposomes (Cur-RL-Lips) were fabricated from rhamnolipid and phospholipids, and then chitosan (CS) covered the surface of Cur-RL-Lips by electrostatic interaction to form CS-coated Cur-RL-Lips.	Curcumin	4-12	citrate synthase	Homo sapiens	203-205
33494543-5	2021	The CS-coated Cur-RL-Lips remained stable from pH 2 to 5 at room temperature and can effectively slow the degradation of curcumin at 80  C; however, they were highly unstable to salt addition.	Curcumin	121-129	citrate synthase	Homo sapiens	4-6
33494543-6	2021	In addition, compared with Cur-RL-Lips, the bioavailability of curcumin in CS-coated Cur-RL-Lips was relatively high due to its high transformation in gastrointestinal tract.	Curcumin	63-71	citrate synthase	Homo sapiens	75-77
33160958-10	2021	Curcumin also increased the expression of proteins involved in neurogenesis (including Ngn2, Pax6 and NeuroD 1) and the Wnt/beta-catenin signaling pathway.	Curcumin	0-8	neurogenin 2	Mus musculus	87-91
33479401-0	2021	Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies.	Curcumin	13-21	angiotensin converting enzyme 2	Homo sapiens	63-67
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Curcumin	70-78	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	130-131
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Curcumin	70-78	angiotensin converting enzyme 2	Homo sapiens	158-162
33096358-4	2021	Firstly, the results showed curcumin could decline HgCl2-induced up-regulated the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	Curcumin	28-36	glutamic--pyruvic transaminase	Homo sapiens	92-116
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Curcumin	70-78	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	227-232
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Curcumin	70-78	angiotensin converting enzyme 2	Homo sapiens	258-262
33435886-0	2021	Iron overload adversely effects bone marrow haematogenesis via SIRT-SOD2-mROS in a process ameliorated by curcumin.	Curcumin	106-114	superoxide dismutase 2	Homo sapiens	68-72
33435886-9	2021	Curcumin treatment ameliorated peripheral blood cells generation, enhanced SIRT3 activity, decreased SOD2 acetylation, inhibited mROS production, and suppressed iron loading-induced autophagy.	Curcumin	0-8	superoxide dismutase 2	Homo sapiens	101-105
33479401-4	2021	It is evident from the present computational study, that catechin and curcumin, not only exhibit strong binding affinity to viral S Protein and host receptor ACE2 but also to their complex (receptor-binding domain (RBD) of the spike protein of SARS-CoV2 and ACE2; RBD/ACE2-complex).	Curcumin	70-78	angiotensin converting enzyme 2	Homo sapiens	258-262
33435886-10	2021	CONCLUSIONS: Our results suggest that curcumin exerts a protective effect on bone marrow by reducing mROS-stimulated autophagic cell death in a manner dependent on the SIRT3/SOD2 pathway.	Curcumin	38-46	superoxide dismutase 2	Homo sapiens	174-178
33479401-5	2021	The binding affinity values of catechin and curcumin for the S protein, ACE2 and RBD/ACE2-complex are - 10.5 and - 7.9 kcal/mol; - 8.9 and - 7.8 kcal/mol; and - 9.1 and - 7.6 kcal/mol, respectively.	Curcumin	44-52	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	61-62
31820701-8	2021	Protein interaction network was constructed by cytoscape, and networks of Hsp90, Curcumin and EGC were merged to get common genes involved in Pkcdelta-Nrf2 and Tlr4 pathway.	Curcumin	81-89	protein kinase C delta	Homo sapiens	142-150
33479401-5	2021	The binding affinity values of catechin and curcumin for the S protein, ACE2 and RBD/ACE2-complex are - 10.5 and - 7.9 kcal/mol; - 8.9 and - 7.8 kcal/mol; and - 9.1 and - 7.6 kcal/mol, respectively.	Curcumin	44-52	angiotensin converting enzyme 2	Homo sapiens	72-76
31820701-10	2021	Main proteins involved were identified as key regulators in Pkcdelta-Nrf2 and Tlr4 pathway for controlling expression of Hsp90 from Curcumin and EGC in inflammation.	Curcumin	132-140	protein kinase C delta	Homo sapiens	60-68
33479401-5	2021	The binding affinity values of catechin and curcumin for the S protein, ACE2 and RBD/ACE2-complex are - 10.5 and - 7.9 kcal/mol; - 8.9 and - 7.8 kcal/mol; and - 9.1 and - 7.6 kcal/mol, respectively.	Curcumin	44-52	angiotensin converting enzyme 2	Homo sapiens	85-89
31820701-11	2021	Docking was performed on main proteins, Hsp90, Pkcdelta and Tlr4 with Curcumin and EGC, significant binding energy was obtained for docked complexes.	Curcumin	70-78	protein kinase C delta	Homo sapiens	47-55
33479401-6	2021	Curcumin directly binds to the receptor binding domain (RBD) of viral S Protein.	Curcumin	0-8	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	70-71
31820701-12	2021	Combinatorial effects of Curcumin and EGC were observed in Pkcdelta-Nrf2 and Tlr4pathway.	Curcumin	25-33	protein kinase C delta	Homo sapiens	59-67
33479401-9	2021	Both catechin and curcumin bind the interface of "RBD/ACE2-complex" and intervene in causing fluctuation of the alpha helices and beta-strands of the protein complex.	Curcumin	18-26	angiotensin converting enzyme 2	Homo sapiens	54-58
33952798-0	2021	Curcumin promotes cholesterol efflux by regulating ABCA1 expression through miR-125a-5p/SIRT6 axis in THP-1 macrophage to prevent atherosclerosis.	Curcumin	0-8	sirtuin 6	Homo sapiens	88-93
33479401-10	2021	Protein-protein interaction studies in presence of curcumin or catechin also corroborate the above findings suggesting the efficacy of these two polyphenols in hindering the formation of S Protein-ACE2 complex.	Curcumin	51-59	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	187-188
33952798-9	2021	Meanwhile, curcumin markedly suppressed the expression of miR-125a-5p and upregulated the expression of SIRT6.	Curcumin	11-19	sirtuin 6	Homo sapiens	104-109
33479401-10	2021	Protein-protein interaction studies in presence of curcumin or catechin also corroborate the above findings suggesting the efficacy of these two polyphenols in hindering the formation of S Protein-ACE2 complex.	Curcumin	51-59	angiotensin converting enzyme 2	Homo sapiens	197-201
33952798-11	2021	Overexpression of SIRT6 partially reversed the inhibition role of miR-125a-5p mimic in the biological function of curcumin.	Curcumin	114-122	sirtuin 6	Homo sapiens	18-23
33952798-12	2021	Silencing of SIRT6 could partially reverse the effect of the miR-125a-5p inhibitor on the biological function of curcumin.	Curcumin	113-121	sirtuin 6	Homo sapiens	13-18
33407412-12	2021	RILD rats with curcumin treatment presented with decreased ALT, AST, ALP, LDH, and maleicdialdehyde (MDA) levels, and elevated TP, superoxide dismutase (SOD), caspase activated DNase (CAD) and glutathione (GSH) levels.	Curcumin	15-23	DNA fragmentation factor subunit beta	Rattus norvegicus	159-182
33397223-0	2021	Virtual screening of curcumin and its analogs against the spike surface glycoprotein of SARS-CoV-2 and SARS-CoV.	Curcumin	21-29	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	58-63
33254976-8	2021	Also, all CCM-loaded NCs showed a perceptible antimalarial activity independently of their coatings (anionic and cationic), with more expressive results for CS-coated NCs.	Curcumin	10-13	citrate synthase	Homo sapiens	157-159
33179078-9	2021	IL-10 level in the colon was significantly increased, while inflammatory cytokines IL-6, IL-17 and IL-23 were significantly reduced following curcumin treatment.	Curcumin	142-150	interleukin 23, alpha subunit p19	Mus musculus	99-104
32420759-11	2021	Combination of quercetin and curcumin was effective on genes that were particularly related to p53, NF-kappaB and TGF-alpha pathways.	Curcumin	29-37	transforming growth factor alpha	Homo sapiens	114-123
33397223-7	2021	In the present study, curcumin and its derivatives were docked, using Autodock 4.2, onto the 6CRV and 6M0J to study their capability to act as inhibitors of the spike protein and thereby, viral entry.	Curcumin	22-30	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	161-166
33397223-10	2021	A good binding energy, drug likeness and efficient pharmacokinetic parameters suggest the potential of curcumin and few of its derivatives as SARS-CoV-2 spike protein inhibitors.	Curcumin	103-111	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	153-158
33747866-9	2021	Regarding cancer metastasis, curcumin and PGV-1 showed inhibitory activities against cell migration and inhibited MMP-2 and MMP-9 protein expression.	Curcumin	29-37	matrix metallopeptidase 9	Mus musculus	124-129
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	transforming growth factor alpha	Homo sapiens	147-155
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	Janus kinase 2	Homo sapiens	182-186
32468854-7	2021	Micellar curcumin (mCur) administered in drinking water significantly reduced AOM/DSS-induced colorectal inflammation in both WT and MGMT-deficient mice as compared to animals receiving drinking water with micelles not containing curcumin.	Curcumin	9-17	O-6-methylguanine-DNA methyltransferase	Mus musculus	133-137
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	MYD88 innate immune signal transduction adaptor	Homo sapiens	241-247
33505130-12	2021	Rabbits treated with curcumin showed a significant reduction in the serum level of high sensitive C-reactive protein, ICAM1, VCAM, PCSK9 serum expression and aortic total antioxidant capacity.	Curcumin	21-29	C-reactive protein	Oryctolagus cuniculus	98-116
33049899-1	2020	This study is aiming to investigate the stabilizing effect of chondroitin sulfate (CS) on the preparation of curcumin nanoparticles (NPs).	Curcumin	109-117	citrate synthase	Homo sapiens	83-85
33316931-1	2020	The present study evaluates the regulatory effect of Nano-Curcumin (Nano-CUR) against tartrazine (TZ)-induced injuries on apoptosis-related gene expression (i.e., p53, CASP-3 and CASP-9), antioxidant status, and DNA damages in bone marrow in treated rats.	Curcumin	58-66	caspase 3	Rattus norvegicus	168-174
33189031-2	2020	Curcumin (cur), which is well-known for having a wide range of biological properties suitable for the treatment of several diseases, was selected as a model for forming the inclusion complex in pbCD and then encapsulated into CS nanoparticles (CSpbCD-cur).	Curcumin	0-8	citrate synthase	Homo sapiens	226-228
33189031-6	2020	Moreover, the loading efficiency of the inclusion complex of curcumin with pbCD (pbCD-cur) entrapped into the CS nanoparticles (CSpbCD-cur), increased when the pbCD-cur concentration was increased.	Curcumin	61-69	citrate synthase	Homo sapiens	110-112
32893845-11	2020	The expression levels of N-cadherin, Vimentin, Wnt3a, Snail1, and Twist, as well as the nuclear translocation levels of ss-catenin, were reduced in a curcumin concentration-dependent manner.	Curcumin	150-158	Wnt family member 3A	Homo sapiens	47-52
32893845-13	2020	CONCLUSIONS Curcumin negatively regulated transcription factors promoting EMT in CRC cells by decreasing cdx2 promoter DNA methylation and consequently suppressing the CDX2/Wnt3a/ss-catenin signaling pathway.	Curcumin	12-20	Wnt family member 3A	Homo sapiens	173-178
32887024-12	2020	The inhibitory effects of curcumin on WNT signal pathway and EMT progress were verified to be consistent with Pax-6, TET1 and NKD2.	Curcumin	26-34	paired box 6	Homo sapiens	110-115
32464442-9	2020	Furthermore, pretreatment of curcumin with arsenic expressively alleviated arsenic-induced toxicity and cell death by reversing the expressions of proteins; mTOR, Akt, Nrf2, ERK1, Bcl-x, Xiap, ULK, LC3, p53, Bax, cytochrome c, caspase 9 and cleaved caspase 3.	Curcumin	29-37	mitogen activated protein kinase 3	Rattus norvegicus	174-178
32464442-9	2020	Furthermore, pretreatment of curcumin with arsenic expressively alleviated arsenic-induced toxicity and cell death by reversing the expressions of proteins; mTOR, Akt, Nrf2, ERK1, Bcl-x, Xiap, ULK, LC3, p53, Bax, cytochrome c, caspase 9 and cleaved caspase 3.	Curcumin	29-37	Bcl2-like 1	Rattus norvegicus	180-185
32464442-9	2020	Furthermore, pretreatment of curcumin with arsenic expressively alleviated arsenic-induced toxicity and cell death by reversing the expressions of proteins; mTOR, Akt, Nrf2, ERK1, Bcl-x, Xiap, ULK, LC3, p53, Bax, cytochrome c, caspase 9 and cleaved caspase 3.	Curcumin	29-37	X-linked inhibitor of apoptosis	Rattus norvegicus	187-191
32464442-9	2020	Furthermore, pretreatment of curcumin with arsenic expressively alleviated arsenic-induced toxicity and cell death by reversing the expressions of proteins; mTOR, Akt, Nrf2, ERK1, Bcl-x, Xiap, ULK, LC3, p53, Bax, cytochrome c, caspase 9 and cleaved caspase 3.	Curcumin	29-37	annexin A3	Rattus norvegicus	198-201
32464442-9	2020	Furthermore, pretreatment of curcumin with arsenic expressively alleviated arsenic-induced toxicity and cell death by reversing the expressions of proteins; mTOR, Akt, Nrf2, ERK1, Bcl-x, Xiap, ULK, LC3, p53, Bax, cytochrome c, caspase 9 and cleaved caspase 3.	Curcumin	29-37	caspase 3	Rattus norvegicus	249-258
32691972-5	2020	Immunohistochemical analysis and qPCR revealed that topically applied curcumin either before, after or in combination with acidic bile exposure significantly suppressed its induced NF-kappaB activation in regenerating epithelial cells, and overexpression of Rela, Bcl2, Egfr, Stat3, Wnt5a, Tnf, Il6, Ptgs2.	Curcumin	70-78	RELA proto-oncogene, NF-kB subunit	Homo sapiens	258-262
32729926-3	2020	OBJECTIVES: We aimed to test the ability of curcumin to rescue the neuromorphological and cognitive alterations of the Ts65Dn (TS) mouse model of DS when administered prenatally or during early postnatal stages, and to evaluate whether these effects were maintained several weeks after the treatment.	Curcumin	44-52	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	119-125
32757174-11	2021	While KCNQ1OT1 overexpression removed the effect of curcumin on HCT8/DDP cells via miR-497/ Bcl-2 axis.	Curcumin	52-60	microRNA 497	Homo sapiens	83-90
32626932-10	2020	In addition, curcumin increased the expression levels of the voltage-gated potassium channels Kv2.1 and Kv3.2.	Curcumin	13-21	potassium voltage-gated channel subfamily C member 2	Homo sapiens	104-109
32626956-11	2020	In addition, the curcumin-induced decreased expression levels of beta-catenin, cyclin D1 and c-Myc were rescued following the genetic knockdown of miR-192-5p.	Curcumin	17-25	cyclin D1	Homo sapiens	79-88
32141025-6	2020	RESULTS: Curcumin augments TRAIL-apoptotic signaling in leukemic cells by upregulating the expression of DR4 and DR5 along with suppression of cFLIP and anti-apoptotic proteins Mcl-1, Bcl-xl, and XIAP.	Curcumin	9-17	TNF receptor superfamily member 10a	Homo sapiens	105-108
32703287-4	2020	METHODS: In this study, we investigated the role of curcumin in regulating the production of several chemokines (CCL2, CCL3 and CX3CL1) and the migration of OCPs by ELISA, Western blotting and Transwell assays.	Curcumin	52-60	chemokine (C-X3-C motif) ligand 1	Mus musculus	128-134
32685814-2	2020	In this present work, we aim to construct a long-circulating delivery system of liposomal curcumin (Cur-Lips) by coating bovine serum albumin (BSA), namely, BSA-coated liposomal curcumin (BSA-Cur-Lips).	Curcumin	90-98	albumin	Mus musculus	128-141
32721183-0	2020	MiR-28-5p mediates the anti-proliferative and pro-apoptotic effects of curcumin on human diffuse large B-cell lymphoma cells.	Curcumin	71-79	microRNA 28	Homo sapiens	0-6
32721183-7	2020	RESULTS: Curcumin decreased the viability of OCI-LY7 cells in a concentration- and time-dependent manner, and these effects were attenuated by miR-28-5p inhibition.	Curcumin	9-17	microRNA 28	Homo sapiens	143-149
33076999-5	2021	The lowest malondialdehyde and the highest superoxide dismutase, catalase activity and total antioxidant capacity were observed in 0.04% curcumin group.	Curcumin	137-145	catalase	Larimichthys crocea	65-73
33224436-0	2020	Protective potential of curcumin in L-NAME-induced hypertensive rat model: AT1R, mitochondrial DNA synergy.	Curcumin	24-32	angiotensin II receptor, type 1a	Rattus norvegicus	75-79
33224436-10	2020	The expression of Bcl2 and caspase-3 was improved associated with downregulation of AT1R in curcumin treated groups.	Curcumin	92-100	caspase 3	Rattus norvegicus	27-36
33224436-10	2020	The expression of Bcl2 and caspase-3 was improved associated with downregulation of AT1R in curcumin treated groups.	Curcumin	92-100	angiotensin II receptor, type 1a	Rattus norvegicus	84-88
33050393-2	2020	The present study developed an NLC containing epidermal growth factor (EGF) and curcumin (EGF-Cur-NLC).	Curcumin	80-88	epidermal growth factor like 1	Rattus norvegicus	90-93
33050393-4	2020	The EGF-Cur-NLC particles showed an average diameter of 331.8 nm and a high encapsulation efficiency (81.1% and 99.4% for EGF and curcumin, respectively).	Curcumin	130-138	epidermal growth factor like 1	Rattus norvegicus	4-7
32399774-6	2020	Protein expressions of MMP-2, MMP-9 and VEGF in the WERI-Rb-1 cells were also significantly inhibited by curcumin in a concentration-dependent manner (0-40 microM).	Curcumin	105-113	matrix metallopeptidase 2	Homo sapiens	23-28
32399774-7	2020	Furthermore, nuclear translocation of NF-kappaB (p65) was significantly inhibited by curcumin in time-dependent manner (6-24 h).	Curcumin	85-93	RELA proto-oncogene, NF-kB subunit	Homo sapiens	49-52
32399774-8	2020	CONCLUSION: Curcumin inhibited proliferation and migration of WERI-Rb-1 cells, a cell line of human retinoblastoma, which might be through modulating NF-kappaB and its downstream proteins including VEGF, MMP-2, and MMP-9.	Curcumin	12-20	matrix metallopeptidase 2	Homo sapiens	204-209
32814232-10	2020	Punicalagin and curcumin also altered antioxidant (SOD2 and catalase) mRNA expression in placenta, VAT and SAT, with minimal effect on hydrogen peroxide concentrations in tissue lysates.	Curcumin	16-24	superoxide dismutase 2	Homo sapiens	51-55
32998472-2	2020	PCL and PHB were also separately electrospinned and loaded with 1 wt% of curcumin.	Curcumin	73-81	prohibitin 1	Homo sapiens	8-11
32776418-0	2020	Curcumin reinforces MSC-derived exosomes in attenuating osteoarthritis via modulating the miR-124/NF-kB and miR-143/ROCK1/TLR9 signalling pathways.	Curcumin	0-8	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	116-121
32776418-4	2020	Additionally, quantitative real-time PCR and Western blot assays showed that the exosomes derived from curcumin-treated MSCs significantly restored the down-regulated miR-143 and miR-124 expression as well as up-regulated NF-kB and ROCK1 expression in OA cells.	Curcumin	103-111	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	232-237
32009245-8	2020	Further, in vitro curcumin intervention inhibited M1-type polarization via the Janus kinase1/2-signal transducer and activator of transcription protein1 (JAK1/2-STAT1) pathway.	Curcumin	18-26	Janus kinase 1	Mus musculus	154-160
32009245-10	2020	Curcumin prevents inflammatory-mediated apoptosis of osteocytes in part through inhibition of M1 polarization through the JAK1/2-STAT1 pathway.	Curcumin	0-8	Janus kinase 1	Mus musculus	122-126
32526690-5	2020	In the current study, we showed that curcumin inhibited TGF-beta/Smad signaling transmission by activating autophagy, thereby inhibiting EMT.	Curcumin	37-45	transforming growth factor alpha	Homo sapiens	56-64
32526690-7	2020	Curcumin inhibits levels of reactive oxygen species (ROS) and oxidative stress in hepatocytes by activating PPAR-alpha, and regulates upstream signaling pathways of autophagy AMPK and PI3K/AKT/mTOR, leading to an increase of the autophagic flow in hepatocytes.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	175-179
32831861-0	2020	Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway.	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	120-126
32831861-6	2020	We found that curcumin inhibited aldosterone-induced C-reactive protein generation in vascular smooth muscle cells by interfering with the reactive oxygen species-ERK1/2 signal pathway.	Curcumin	14-22	mitogen activated protein kinase 3	Rattus norvegicus	163-169
32502496-0	2020	The pivotal role of SUMO-1-JNK-Tau axis in an in vitro model of oxidative stress counteracted by the protective effect of curcumin.	Curcumin	122-130	small ubiquitin like modifier 1	Homo sapiens	20-26
32502496-5	2020	Curcumin, a natural compound with anti-oxidant and anti-inflammatory effects, demonstrated to tackle oxidative stress re-equilibrating SUMO-1, JNK and Tau functions.	Curcumin	0-8	small ubiquitin like modifier 1	Homo sapiens	135-141
32502496-7	2020	Interestingly, we found that H2O2 treatment induced a strong co-localization of SUMO-1-p-JNK-Tau proteins in nuclear bodies (NBs) and that curcumin was able to reduce these nuclear aggregates.	Curcumin	139-147	small ubiquitin like modifier 1	Homo sapiens	80-86
32502496-8	2020	These results highlight the SUMO-1-JNK-Tau axis key role in oxidative stress and the protective effect of curcumin against this pathological event, focusing on the importance of SUMO/deSUMOylation balance to regulate essential cellular processes.	Curcumin	106-114	small ubiquitin like modifier 1	Homo sapiens	28-34
32724322-8	2020	Meanwhile, the curcumin treatment can downregulate miR-21 expression, upregulate TIMP3 expression, and inhibit the TGF-beta1/smad3 signaling pathway.	Curcumin	15-23	SMAD family member 3	Homo sapiens	125-130
32724322-11	2020	Interestingly, the effect of miR-21 inhibition on cell proliferation, apoptosis, and TGF-beta1/smad3 signaling pathway in HepG2 and HCCLM3 cells exposed to curcumin was attenuated by TIMP3 silencing.	Curcumin	156-164	SMAD family member 3	Homo sapiens	95-100
32724322-12	2020	Conclusion: Taken together, the present study suggests that miR-21 is involved in the anticancer activities of curcumin through targeting TIMP3, and the mechanism possibly refers to the inhibition of TGF-beta1/smad3 signaling pathway.	Curcumin	111-119	SMAD family member 3	Homo sapiens	210-215
32714183-0	2020	LincROR Mediates the Suppressive Effects of Curcumin on Hepatocellular Carcinoma Through Inactivating Wnt/beta-Catenin Signaling.	Curcumin	44-52	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	0-7
32714183-6	2020	Several previously reported lncRNAs related to tumorigenesis were chosen for examination of their expression profiles, and lincROR was found to be the most down-regulated in the Curcumin-treated HCC cells.	Curcumin	178-186	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	123-130
33505130-12	2021	Rabbits treated with curcumin showed a significant reduction in the serum level of high sensitive C-reactive protein, ICAM1, VCAM, PCSK9 serum expression and aortic total antioxidant capacity.	Curcumin	21-29	LOW QUALITY PROTEIN: proprotein convertase subtilisin/kexin type 9	Oryctolagus cuniculus	131-136
32714183-8	2020	Therefore, Curcumin suppressed tumor growth through a lincROR/beta-catenin regulatory pattern.	Curcumin	11-19	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	54-61
32714183-9	2020	In conclusion, our results demonstrated that Curcumin suppressed the cell proliferation via the down-regulation of lincROR and inactivation of Wnt/beta-catenin signaling, suggesting that it may be a potential anti-cancer candidate for HCC patients with activated Wnt/beta-catenin signaling.	Curcumin	45-53	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	115-122
33179078-11	2021	It was concluded that oral administration of curcumin can effectively treat experimental colitis by regulating the re-equilibration of Treg/Th17 and that the regulatory mechanism may be closely related to the IL-23/Th17 pathway.	Curcumin	45-53	interleukin 23, alpha subunit p19	Mus musculus	209-214
32464055-0	2020	Solid lipid nanoparticles enhanced the neuroprotective role of curcumin against epilepsy through activation of Bcl-2 family and P38 MAPK pathway.	Curcumin	63-71	mitogen-activated protein kinase 14	Mus musculus	128-136
33953873-5	2021	In this study, the effect of curcumin administration on the change of the expression of MBP, NOGO-A, and iNOS genes was evaluated using the RT-PCR (Reverse transcription-polymerase chain reaction) technique.	Curcumin	29-37	nitric oxide synthase, inducible	Cavia porcellus	105-109
33213437-0	2020	The inhibitory effect of curcumin via fascin suppression through JAK/STAT3 pathway on metastasis and recurrence of ovary cancer cells.	Curcumin	25-33	fascin actin-bundling protein 1	Homo sapiens	38-44
33213437-4	2020	Although there have been many reports regarding the anticancer properties of curcumin, its inhibitory effects on migration and invasion of ovarian cancer cells, particularly in the context of fascin expression, have not been reported.	Curcumin	77-85	fascin actin-bundling protein 1	Homo sapiens	192-198
33213437-5	2020	The purpose of this study was to investigate the effect of curcumin on fascin expression in ovarian cancer cells and to propose a possible mechanism for the anticancer activity of curcumin through reduced fascin expression.	Curcumin	59-67	fascin actin-bundling protein 1	Homo sapiens	71-77
33213437-5	2020	The purpose of this study was to investigate the effect of curcumin on fascin expression in ovarian cancer cells and to propose a possible mechanism for the anticancer activity of curcumin through reduced fascin expression.	Curcumin	180-188	fascin actin-bundling protein 1	Homo sapiens	71-77
33213437-5	2020	The purpose of this study was to investigate the effect of curcumin on fascin expression in ovarian cancer cells and to propose a possible mechanism for the anticancer activity of curcumin through reduced fascin expression.	Curcumin	180-188	fascin actin-bundling protein 1	Homo sapiens	205-211
33213437-8	2020	To determine the effect of curcumin on the upstream pathway of fascin expression, the signal transducer and activator of transcription 3 (STAT3) was analyzed by sandwich-ELISA.	Curcumin	27-35	fascin actin-bundling protein 1	Homo sapiens	63-69
33213437-12	2020	Curcumin appears to suppress fascin expression, even with a minimal concentration and short exposure time.	Curcumin	0-8	fascin actin-bundling protein 1	Homo sapiens	29-35
33213437-13	2020	Also, curcumin may suppress fascin expression in ovarian cancer cells through STAT3 downregulation.	Curcumin	6-14	fascin actin-bundling protein 1	Homo sapiens	28-34
33213437-16	2020	CONCLUSIONS: Curcumin reduces fascin expression through JAK/STAT3 pathway inhibition, which interferes with the cellular interactions essential for the metastasis and recurrence of ovarian cancer cells.	Curcumin	13-21	fascin actin-bundling protein 1	Homo sapiens	30-36
33213437-17	2020	Higher curcumin concentrations and longer exposure times concomitantly decreased fascin expression.	Curcumin	7-15	fascin actin-bundling protein 1	Homo sapiens	81-87
33312126-6	2020	CDD was rapidly metabolized into monoethylsuccinyl curcumin and curcumin in LS9 of all tested species mainly by carboxylesterases (CESs), including CES1 and CES2, and butyrylcholinesterase.	Curcumin	51-59	carboxylesterase 1	Homo sapiens	112-129
33312126-6	2020	CDD was rapidly metabolized into monoethylsuccinyl curcumin and curcumin in LS9 of all tested species mainly by carboxylesterases (CESs), including CES1 and CES2, and butyrylcholinesterase.	Curcumin	51-59	carboxylesterase 1	Homo sapiens	148-152
33184252-12	2020	A marked increase in arginase-1 expression in rats with bone trauma was caused by curcumin treatment.	Curcumin	82-90	arginase 1	Rattus norvegicus	21-31
32745765-7	2020	At the mechanistic level, the destabilization of HIF-1alpha and the up-regulated expression of PGC-1alpha and SIRT3 synergistically contributed to the protective effects of hypoxic preconditioning combined with curcumin in BMSCs.	Curcumin	211-219	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	95-105
32745765-10	2020	Furthermore, knockdown of SIRT3 and PGC-1alpha by RNAi both led to caspase-3 activation in BMSCs after hypoxia and curcumin treatment.	Curcumin	115-123	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	36-46
32745765-11	2020	Notably, SIRT3 RNAi suppressed OXPHOS activity, while PGC-1alpha RNAi triggered mitochondrial superoxide and intracellular H2O2 production in hypoxia combined with curcumin-treated BMSCs.	Curcumin	164-172	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	54-64
32835867-3	2020	Curcumin treatment enhances CTSC level in CRCs; however, CTSC silencing with subsequent curcumin treatment (sequential treatment) induces ER stress and autophagic dysregulation accompanied by lysosomal permeabilization and ROS generation.	Curcumin	88-96	cathepsin C	Mus musculus	57-61
32835867-6	2020	Indeed, the sequential CTSC silencing and curcumin treatment also significantly curtailed tumor volume as well as ameliorated cytosolic cyt c and tBID protein levels in tumor tissues compared to those in control and individual treatments of CTSC targeting and on curcumin treatment in nude mice xenografts.	Curcumin	42-50	cathepsin C	Mus musculus	241-245
32835867-6	2020	Indeed, the sequential CTSC silencing and curcumin treatment also significantly curtailed tumor volume as well as ameliorated cytosolic cyt c and tBID protein levels in tumor tissues compared to those in control and individual treatments of CTSC targeting and on curcumin treatment in nude mice xenografts.	Curcumin	263-271	cathepsin C	Mus musculus	23-27
32835867-7	2020	The results reveal that CTSC controls the curcumin-induced cytotoxic insult through autophagy maintenance both in vitro and in athymic mice xenografts, thereby providing an insight into the role of CTSC in chemoprevention of CRCs.	Curcumin	42-50	cathepsin C	Mus musculus	24-28
32835867-7	2020	The results reveal that CTSC controls the curcumin-induced cytotoxic insult through autophagy maintenance both in vitro and in athymic mice xenografts, thereby providing an insight into the role of CTSC in chemoprevention of CRCs.	Curcumin	42-50	cathepsin C	Mus musculus	198-202
32866906-0	2020	Curcumin inhibits proteasome activity in triple-negative breast cancer cells through regulating p300/miR-142-3p/PSMB5 axis.	Curcumin	0-8	E1A binding protein p300	Homo sapiens	96-100
32866906-15	2020	Overexpression of p300 mitigated the promotive effect of curcumin on miR-142-3p expression.	Curcumin	57-65	E1A binding protein p300	Homo sapiens	18-22
32866906-19	2020	These curcumin-induced changes on p300, miR-142-3p, PSMB5, and 20S proteasome activity were further confirmed in in vivo solid tumor model.	Curcumin	6-14	E1A binding protein p300	Homo sapiens	34-38
32866906-20	2020	CONCLUSION: These findings demonstrated that curcumin suppressed p300/miR-142-3p/PSMB5 axis leading to the inhibition of the CT-l activity of 20S proteasome.	Curcumin	45-53	E1A binding protein p300	Homo sapiens	65-69
32338107-10	2020	Bioinformatics prediction and western blotting methods validated the targets of miR-181a in vitro.Results: Curcumin treatment alleviated cisplatin-induced nephrotoxicity as validated by the blood urea nitrogen (BUN) values, and histological analysis of kidneys.	Curcumin	107-115	microRNA 181a-2	Mus musculus	80-88
32338107-11	2020	At the molecular level, curcumin treatment decreased miR-181a expression level, which was induced by cisplatin and restored the in vivo expression of PTEN, which was suppressed by cisplatin.	Curcumin	24-32	microRNA 181a-2	Mus musculus	53-61
32338107-12	2020	We verified the direct regulation of PTEN by miR-181a in cultured human embryonic kidney 293T cells.Conclusions: We showed the involvement of miR-181a/PTEN axis in the renoprotective effect of curcumin against cisplatin-induced AKI, and provide new evidence on the ability of curcumin to alleviate cisplatin-induced nephrotoxicity.	Curcumin	193-201	microRNA 181a-2	Mus musculus	45-53
32338107-12	2020	We verified the direct regulation of PTEN by miR-181a in cultured human embryonic kidney 293T cells.Conclusions: We showed the involvement of miR-181a/PTEN axis in the renoprotective effect of curcumin against cisplatin-induced AKI, and provide new evidence on the ability of curcumin to alleviate cisplatin-induced nephrotoxicity.	Curcumin	193-201	microRNA 181a-2	Mus musculus	142-150
33149560-8	2020	However, 4 polyphenols such as epigallocatechin gallate (EGCG), homoeriodictyol, isorhamnetin, and curcumin interact, in addition to the Spike protein and its binding sites in GRP78, with the ATPase domain of GRP78.	Curcumin	99-107	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	137-142
33178666-3	2020	Curcumin inhibits Bcl-2, Bcl-XL, VEGF, c-Myc, ICAM-1, EGFR, STAT3 phosphorylation, and cyclin D1 genes involved in the various stages of breast, prostate, and gastric cancer proliferation, angiogenesis, invasion, and metastasis.	Curcumin	0-8	cyclin D1	Homo sapiens	87-96
33061628-0	2020	Curcumin Modifies Epithelial-Mesenchymal Transition in Colorectal Cancer Through Regulation of miR-200c/EPM5.	Curcumin	0-8	microRNA 200c	Homo sapiens	95-103
33061628-15	2020	Conclusion: Our data provide the first evidence that the curcumin inhibits EMT in CRC by upregulation of miR-200c and downregulation of EPM5, and the use of curcumin might be able to prevent or delay CRC progression.	Curcumin	57-65	microRNA 200c	Homo sapiens	105-113
31985048-0	2020	(Curcumin+sildenafil) enhances the efficacy of 5FU and anti-PD1 therapies in vivo.	Curcumin	1-20	programmed cell death 1	Homo sapiens	60-63
33025506-6	2020	In this current study, we elucidate the role of C1qbp during curcumin induced chemosensitization to doxorubicin resistant colon cancer cells.	Curcumin	61-69	complement C1q binding protein	Homo sapiens	48-53
33025506-7	2020	The possible interaction between C1qbp and curcumin was determined using bioinformatics tools-AutoDock, SYBYL, and PyMol.	Curcumin	43-51	complement C1q binding protein	Homo sapiens	33-38
33025506-13	2020	Through molecular docking we identified possible interaction between curcumin and C1qbp.	Curcumin	69-77	complement C1q binding protein	Homo sapiens	82-87
33025506-16	2020	Hence, curcumin could interact directly with C1qbp protein and this interaction could contribute to the chemosensiting effect to doxorubicin in colon cancer cells.	Curcumin	7-15	complement C1q binding protein	Homo sapiens	45-50
32060973-3	2020	In the present study, we found that curcumin reversed the phenotype of CAFs to that of peri-tumor fibroblasts (PTFs)-like cells by downregulating the expression of alpha-SMA (a special marker for CAFs) and inhibiting the secretion of pro-carcinogenic cytokines, including transforming growth factor-beta1 (TGF-beta1), matrix metalloproteinases 2 (MMP2), and stromal cell-derived factor-1 (SDF-1).	Curcumin	36-44	matrix metallopeptidase 2	Homo sapiens	318-345
32060973-3	2020	In the present study, we found that curcumin reversed the phenotype of CAFs to that of peri-tumor fibroblasts (PTFs)-like cells by downregulating the expression of alpha-SMA (a special marker for CAFs) and inhibiting the secretion of pro-carcinogenic cytokines, including transforming growth factor-beta1 (TGF-beta1), matrix metalloproteinases 2 (MMP2), and stromal cell-derived factor-1 (SDF-1).	Curcumin	36-44	matrix metallopeptidase 2	Homo sapiens	347-351
32721183-8	2020	MiR-28-5p expression was upregulated by curcumin.	Curcumin	40-48	microRNA 28	Homo sapiens	0-6
32060973-3	2020	In the present study, we found that curcumin reversed the phenotype of CAFs to that of peri-tumor fibroblasts (PTFs)-like cells by downregulating the expression of alpha-SMA (a special marker for CAFs) and inhibiting the secretion of pro-carcinogenic cytokines, including transforming growth factor-beta1 (TGF-beta1), matrix metalloproteinases 2 (MMP2), and stromal cell-derived factor-1 (SDF-1).	Curcumin	36-44	C-X-C motif chemokine ligand 12	Homo sapiens	358-387
32060973-3	2020	In the present study, we found that curcumin reversed the phenotype of CAFs to that of peri-tumor fibroblasts (PTFs)-like cells by downregulating the expression of alpha-SMA (a special marker for CAFs) and inhibiting the secretion of pro-carcinogenic cytokines, including transforming growth factor-beta1 (TGF-beta1), matrix metalloproteinases 2 (MMP2), and stromal cell-derived factor-1 (SDF-1).	Curcumin	36-44	C-X-C motif chemokine ligand 12	Homo sapiens	389-394
32721183-9	2020	Curcumin increased the numbers of apoptotic cells and upregulated cleaved caspase-3 expression, and these effects were attenuated by miR-28-5p inhibition.	Curcumin	0-8	microRNA 28	Homo sapiens	133-139
32721183-12	2020	CONCLUSIONS: Our results described the curcumin exerted anti-proliferative and pro-apoptotic effects on OCI-LY7 cells through a mechanism potentially involving miR-28-5p.	Curcumin	39-47	microRNA 28	Homo sapiens	160-166
32060973-6	2020	In conclusion, our data suggest that curcumin reverses cell phenotype from CAF to PTF-like cells, and suppresses the CAF-mediated proliferation and tumorigenicity of Cal27 by inhibiting TSCC CAFs.	Curcumin	37-45	lysine acetyltransferase 2B	Homo sapiens	75-78
32802291-9	2020	CU+LLLT decreases Bax/Bcl2 ratio which is an indicator of apoptosis and it also rescued a decrease in LC3 and ATG10 expression in comparison with 6-OHDA group.	Curcumin	0-2	annexin A3	Rattus norvegicus	102-105
32060973-6	2020	In conclusion, our data suggest that curcumin reverses cell phenotype from CAF to PTF-like cells, and suppresses the CAF-mediated proliferation and tumorigenicity of Cal27 by inhibiting TSCC CAFs.	Curcumin	37-45	lysine acetyltransferase 2B	Homo sapiens	117-120
32802291-0	2020	The Effect of Low-Level Laser Therapy and Curcumin on the Expression of LC3, ATG10 and BAX/BCL2 Ratio in PC12 Cells Induced by 6-Hydroxide Dopamine.	Curcumin	42-50	annexin A3	Rattus norvegicus	72-75
32572733-9	2020	Curcumin was found to block mRNA expressions of non- SMAD genes EGFR, JNK-1, JAK1, JAK2, STAT-1, STAT-3, MAPK14, also of TGF-beta1 and SMAD genes like SMAD 2, SMAD 3.	Curcumin	0-8	Janus kinase 1	Mus musculus	77-81
33061449-11	2020	Furthermore, curcumin showed the same inhibitory effect as XMD8-92 and significantly reversed CS-induced EMT through inhibiting the ERK5/AP-1 signaling pathway.	Curcumin	13-21	citrate synthase	Homo sapiens	94-96
32572733-9	2020	Curcumin was found to block mRNA expressions of non- SMAD genes EGFR, JNK-1, JAK1, JAK2, STAT-1, STAT-3, MAPK14, also of TGF-beta1 and SMAD genes like SMAD 2, SMAD 3.	Curcumin	0-8	mitogen-activated protein kinase 14	Mus musculus	105-111
32572733-9	2020	Curcumin was found to block mRNA expressions of non- SMAD genes EGFR, JNK-1, JAK1, JAK2, STAT-1, STAT-3, MAPK14, also of TGF-beta1 and SMAD genes like SMAD 2, SMAD 3.	Curcumin	0-8	transforming growth factor, beta 1	Mus musculus	121-130
32531667-0	2020	Curcumin ameliorates CKD-induced mitochondrial dysfunction and oxidative stress through inhibiting GSK-3beta activity.	Curcumin	0-8	glycogen synthase kinase 3 alpha	Mus musculus	99-108
32572733-9	2020	Curcumin was found to block mRNA expressions of non- SMAD genes EGFR, JNK-1, JAK1, JAK2, STAT-1, STAT-3, MAPK14, also of TGF-beta1 and SMAD genes like SMAD 2, SMAD 3.	Curcumin	0-8	SMAD family member 3	Mus musculus	159-165
32572733-10	2020	However, mRNA expressions of SMAD 6 and SMAD 7 were increased upon curcumin intervention.	Curcumin	67-75	SMAD family member 7	Mus musculus	40-46
32151947-9	2020	Curcumin improved myelination potential via increasing beta-III tubulin-/MBP+ cells (neuron-oligodendrocyte co-culture) and augmented fluoromyelin intensity and neurofilament/MBP+ neurons in vivo.	Curcumin	0-8	myelin basic protein	Homo sapiens	73-76
32151947-9	2020	Curcumin improved myelination potential via increasing beta-III tubulin-/MBP+ cells (neuron-oligodendrocyte co-culture) and augmented fluoromyelin intensity and neurofilament/MBP+ neurons in vivo.	Curcumin	0-8	myelin basic protein	Homo sapiens	175-178
32151947-10	2020	In silico docking studies suggested Notch pathway genes (Notch-1, Hes-1 and Mib-1) as potential targets of BPA and curcumin.	Curcumin	115-123	hes family bHLH transcription factor 1	Homo sapiens	66-71
32279988-7	2020	In addition, activation profiles of OECs by CCM stimulus were assessed and levels of transglutaminase-2 (TG2) and phosphatidylserine receptor (PSR) in OECs stimulated by CCM were further determined.	Curcumin	170-173	transglutaminase 2	Rattus norvegicus	85-103
32279988-7	2020	In addition, activation profiles of OECs by CCM stimulus were assessed and levels of transglutaminase-2 (TG2) and phosphatidylserine receptor (PSR) in OECs stimulated by CCM were further determined.	Curcumin	170-173	transglutaminase 2	Rattus norvegicus	105-108
32279988-9	2020	In addition, the levels of TG2 and PSR in CCM-treated OECs were significantly elevated.	Curcumin	42-45	transglutaminase 2	Rattus norvegicus	27-30
32472767-3	2020	Moreover, curcumin prevents HG induced increase in expression of CHOP, decrease in PCG-1a and phosphorylation of ERK1/2 (pERK1/2) without any effect on the phosphorylation levels of p38 and JNK.	Curcumin	10-18	mitogen-activated protein kinase 3	Mus musculus	113-119
32472767-6	2020	These results suggest that curcumin acts through CHOP/PCG-1a and ERK1/2 signaling to block the HG induced oxidative stress and apoptosis.	Curcumin	27-35	mitogen-activated protein kinase 3	Mus musculus	65-71
32472295-9	2020	Furthermore, curcumin suppressed p-p65 expression via regulating miR-362-3p/TLR4 axis.	Curcumin	13-21	microRNA 362	Mus musculus	65-72
32472295-10	2020	We discovered that curcumin exhibited protective effects against LPS-triggered cell injury via modulating miR-362-3p/TLR4 axis through NF-kappaB pathway.	Curcumin	19-27	microRNA 362	Mus musculus	106-113
32278045-0	2020	The anticancer effects of curcumin via targeting the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway.	Curcumin	26-34	CREB regulated transcription coactivator 1	Mus musculus	94-100
32278045-6	2020	However, the exact underlying mechanisms by which curcumin blocks the mTORC1 signaling remain unclear.	Curcumin	50-58	CREB regulated transcription coactivator 1	Mus musculus	70-76
32278045-7	2020	According to literature, curcumin inhibits insulin-like growth factor 1 (IGF-1)/phosphoinositide 3-kinase (PI3K)/Akt/mTORC1 pathway which leads to apoptosis and cell cycle arrest via suppression of erythroblastosis virus transcription factor 2 and murine double minute 2 oncoprotein.	Curcumin	25-33	insulin-like growth factor 1	Mus musculus	43-71
32278045-7	2020	According to literature, curcumin inhibits insulin-like growth factor 1 (IGF-1)/phosphoinositide 3-kinase (PI3K)/Akt/mTORC1 pathway which leads to apoptosis and cell cycle arrest via suppression of erythroblastosis virus transcription factor 2 and murine double minute 2 oncoprotein.	Curcumin	25-33	insulin-like growth factor 1	Mus musculus	73-78
32278045-7	2020	According to literature, curcumin inhibits insulin-like growth factor 1 (IGF-1)/phosphoinositide 3-kinase (PI3K)/Akt/mTORC1 pathway which leads to apoptosis and cell cycle arrest via suppression of erythroblastosis virus transcription factor 2 and murine double minute 2 oncoprotein.	Curcumin	25-33	CREB regulated transcription coactivator 1	Mus musculus	117-123
32278045-8	2020	In addition, activation of unc-51-like kinase 1 by curcumin, as a downstream target of IGF-1/PI3K/Akt/mTORC1 axis, enhances autophagy.	Curcumin	51-59	insulin-like growth factor 1	Mus musculus	87-92
32278045-8	2020	In addition, activation of unc-51-like kinase 1 by curcumin, as a downstream target of IGF-1/PI3K/Akt/mTORC1 axis, enhances autophagy.	Curcumin	51-59	CREB regulated transcription coactivator 1	Mus musculus	102-108
32278045-9	2020	Curcumin induces AMP-activated protein kinase, a negative regulator of mTORC1, via inhibition of F0F1-ATPase.	Curcumin	0-8	CREB regulated transcription coactivator 1	Mus musculus	71-77
32278045-9	2020	Curcumin induces AMP-activated protein kinase, a negative regulator of mTORC1, via inhibition of F0F1-ATPase.	Curcumin	0-8	ATP synthase F1 subunit epsilon	Homo sapiens	97-108
32278045-10	2020	Interestingly, curcumin suppresses IkappaB kinase beta, the upstream kinase in mTORC1 pathway.	Curcumin	15-23	CREB regulated transcription coactivator 1	Mus musculus	79-85
32656311-10	2020	Our study exhibited that curcumin, nimbin, withaferin A, piperine, mangiferin, thebaine, berberine, and andrographolide have significant binding affinity towards spike glycoprotein of SARS-CoV-2 and ACE2 receptor and may be useful as a therapeutic and/or prophylactic agent for restricting viral attachment to the host cells.	Curcumin	25-33	angiotensin converting enzyme 2	Homo sapiens	199-203
32124251-4	2020	Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment.	Curcumin	0-8	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	165-173
32485495-9	2020	Further experiments showed that curcumin can upregulate the Nrf2-Keap1 signaling pathway at the transcriptional level, and this upregulation can induce downstream defense genes, including glutamate cysteine ligase catalytic subunit(GCLC) and glutamate cysteine ligase modifier subunit (GCLM), and thereby promote GSH synthesis and the expression of related antioxidases.	Curcumin	32-40	kelch-like ECH-associated protein 1	Oreochromis niloticus	65-70
31654258-8	2020	In addition, CUR and/or Se reduced serum C-reactive protein, liver pro-inflammatory cytokines, and the expression of TLR4, NF-kappaB, JNK, and p38, and upregulated heme oxygenase-1 (HO-1).	Curcumin	13-16	mitogen activated protein kinase 14	Rattus norvegicus	143-146
32229332-4	2020	Curcumin-loaded HPPS (Cur-HPPS) were taken up specifically and efficiently by monocytes through the scavenger receptor class B type I (SR-B1) receptor.	Curcumin	0-8	scavenger receptor class B, member 1	Mus musculus	100-133
32832891-8	2020	Results: At 4 and at 24 hours, curcumin and quercetin have shown protective systemic effects, decreasing significantly the oxidative stress (malondialdehyde level) and stimulating significantly the antioxidant protection (ceruloplasmin and glutathione levels) compared to the group that received only carrageenan.	Curcumin	31-39	ceruloplasmin	Rattus norvegicus	222-235
32612986-0	2020	Curcumin Protects Osteoblasts From Oxidative Stress-Induced Dysfunction via GSK3beta-Nrf2 Signaling Pathway.	Curcumin	0-8	glycogen synthase kinase 3 alpha	Homo sapiens	76-84
32529309-7	2020	A confirmatory In Vitro study with paclitaxel, the 6alpha-hydroxylation of which is exclusively mediated by CYP2C8, was consistent with a potent inhibition of this enzyme by curcumin.	Curcumin	174-182	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	108-114
32529309-11	2020	Although curcumin possesses a strong In Vitro inhibitory activity towards CYP3A4 and CYP2C8 enzymes, its interactions with imatinib and bosutinib were unlikely to be of clinical importance due to curcumin"s poor bioavailability.	Curcumin	9-17	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	85-91
32512851-0	2020	A Computational Approach with Biological Evaluation: Combinatorial Treatment of Curcumin and Exemestane Synergistically Regulates DDX3 Expression in Cancer Cell Lines.	Curcumin	80-88	DEAD-box helicase 3 X-linked	Homo sapiens	130-134
32512851-9	2020	However, upon combinatorial treatment of curcumin (10 and 20 muM) and exemestane (50 muM) a synergism was exhibited, strikingly downregulating the DDX3 expression and has enhanced apoptosis in three cell lines.	Curcumin	41-49	DEAD-box helicase 3 X-linked	Homo sapiens	147-151
32512851-10	2020	The obtained results illuminate the use of curcumin as an alternative DDX3 inhibitor and can serve as a chemical scaffold to design new small molecules.	Curcumin	43-51	DEAD-box helicase 3 X-linked	Homo sapiens	70-74
32391111-6	2020	However, at present, the potential effects of curcumin on HGF-induced EMT in OSCC have not been investigated.	Curcumin	46-54	hepatocyte growth factor	Homo sapiens	58-61
32391111-8	2020	Notably, curcumin inhibited HGF-induced EMT and cell motility in HSC-4 and Ca9-22 cells via c-Met blockade.	Curcumin	9-17	hepatocyte growth factor	Homo sapiens	28-31
32391111-10	2020	Furthermore, curcumin was able to effectively inhibit the HGF-induced increase in the levels of vimentin by downregulating the expression of phosphorylated c-Met, an ERK.	Curcumin	13-21	hepatocyte growth factor	Homo sapiens	58-61
32391111-11	2020	In conclusion, the results of the present study demonstrated that curcumin was able to reverse HGF-induced EMT, possibly by inhibiting c-Met expression in oral cancer cells, providing a strong basis for the development of novel approaches for the treatment of oral cancer.	Curcumin	66-74	hepatocyte growth factor	Homo sapiens	95-98
32278045-13	2020	Finally another suggested mechanism is suppression of MAOA/mTORC1/hypoxia-inducible factor 1alpha signaling pathway by curcumin.	Curcumin	119-127	CREB regulated transcription coactivator 1	Mus musculus	59-65
32068061-5	2020	The spherical-like CUR-conjugated system (CUR-CS-ZnO) with the average particle size of 40 nm presented significantly enhanced water dispersibility versus free CUR.	Curcumin	19-22	citrate synthase	Homo sapiens	46-48
32375323-9	2020	Furthermore, OLETF rats exercised and fed curcumin had lower IL6, TNFalpha, and IL10 levels (indicators of inflammatory response) and lower levels of ER stress markers (BiP and CHOP) in the intestine than OLETF controls.	Curcumin	42-50	growth differentiation factor 10	Rattus norvegicus	169-172
33447259-0	2020	The effects of nanomicelle of curcumin on the matrix metalloproteinase (MMP-2, 9) activity and expression in patients with coronary artery disease (CAD): A randomized controlled clinical trial.	Curcumin	30-38	matrix metallopeptidase 2	Homo sapiens	72-80
33447259-4	2020	The present study was a clinical trial for investigating the effects of curcumin on activity and gene expression of MMP-2 and MMP-9 in patients with CAD.	Curcumin	72-80	matrix metallopeptidase 2	Homo sapiens	116-121
33447259-11	2020	Furthermore, the zymographic analysis showed that the administration of curcumin significantly inhibited the activity levels of MMP-2 (12469.7 +- 5308.64 pixels) and MMP-9 (14007.2 +- 5371.67 pixels) in comparison with that in patients receiving placebo (MMP-2: 17613.8 +- 5250.68 pixels; MMP-9: 20010.1 +- 3259.37 pixels) (P < 0.0500).	Curcumin	72-80	matrix metallopeptidase 2	Homo sapiens	128-133
33447259-11	2020	Furthermore, the zymographic analysis showed that the administration of curcumin significantly inhibited the activity levels of MMP-2 (12469.7 +- 5308.64 pixels) and MMP-9 (14007.2 +- 5371.67 pixels) in comparison with that in patients receiving placebo (MMP-2: 17613.8 +- 5250.68 pixels; MMP-9: 20010.1 +- 3259.37 pixels) (P < 0.0500).	Curcumin	72-80	matrix metallopeptidase 2	Homo sapiens	255-260
33447259-12	2020	CONCLUSION: Our results show that curcumin can significantly reduce the expression and activity of MMP-2 and MMP-9.	Curcumin	34-42	matrix metallopeptidase 2	Homo sapiens	99-104
32370057-0	2020	Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4.	Curcumin	0-8	TNF receptor superfamily member 10a	Homo sapiens	135-138
32037797-7	2020	Curcumin supplementation at 200 mg/kg up-regulated the levels of AKT, NGF, mTOR, Nrf2 and HO-1 mRNA, and concomitantly down-regulated Bax, caspases-3 and -9 mRNA; it also decreased caspase-3 and caspase-9 activity.	Curcumin	0-8	caspase 9	Mus musculus	195-204
32531667-3	2020	The aim of this study was to investigate whether curcumin could improve chronic kidney disease (CKD)-induced muscle atrophy and mitochondrial dysfunction by inhibiting glycogen synthase kinase-3beta (GSK-3beta) activity.	Curcumin	49-57	glycogen synthase kinase 3 alpha	Mus musculus	200-209
32531667-9	2020	Moreover, the protective effects of curcumin had been found to be mediated via inhibiting GSK-3beta activity in vitro and in vivo.	Curcumin	36-44	glycogen synthase kinase 3 alpha	Mus musculus	90-99
32059909-8	2020	Curcumin was released faster at pH 5.5 than that at pH 7.4 from the curcumin-loaded nanoparticles (Cur-NPs), indicating the pH-triggered release capacity of Cur-NPs after endocytosis by endosomes since the pH is low to 5.0~6.0 in endosomes.	Curcumin	0-8	phenylalanine hydroxylase	Homo sapiens	32-34
32531667-11	2020	Overall, this study suggested that curcumin alleviated CKD-induced mitochondrial oxidative damage and mitochondrial dysfunction via inhibiting GSK-3beta activity in skeletal muscle.	Curcumin	35-43	glycogen synthase kinase 3 alpha	Mus musculus	143-152
32436614-0	2020	Curcumin alleviates OGD/R-induced PC12 cell damage via repressing CCL3 and inactivating TLR4/MyD88/MAPK/NF-kappaB to suppress inflammation and apoptosis.	Curcumin	0-8	C-C motif chemokine ligand 3	Rattus norvegicus	66-70
32436614-9	2020	Moreover, we found that CCL3 was a potential target of curcumin in cerebral I/R injury.	Curcumin	55-63	C-C motif chemokine ligand 3	Rattus norvegicus	24-28
32436614-10	2020	More importantly, the following experiments illustrated that curcumin inhibited the expression of CCL3 in OGD/R model and reduced cell apoptosis and inflammation.	Curcumin	61-69	C-C motif chemokine ligand 3	Rattus norvegicus	98-102
31909882-7	2020	Cu inhibits high mobility group box 1 (HMGB1) signaling pathway in db/db mice.	Curcumin	0-2	high mobility group box 1	Mus musculus	12-37
31909882-7	2020	Cu inhibits high mobility group box 1 (HMGB1) signaling pathway in db/db mice.	Curcumin	0-2	high mobility group box 1	Mus musculus	39-44
32436614-12	2020	CONCLUSIONS: Our study manifested that curcumin might be a meritorious drug for the treatment of cerebral ischaemia by acting on CCL3.	Curcumin	39-47	C-C motif chemokine ligand 3	Rattus norvegicus	129-133
32757994-0	2020	Curcumin Suppresses Cell Proliferation, Migration, and Invasion Through Modulating miR-21-5p/SOX6 Axis in Hepatocellular Carcinoma.	Curcumin	0-8	SRY-box transcription factor 6	Homo sapiens	93-97
32627518-0	2020	Long noncoding RNA GAS5 enhanced by curcumin relieves poststroke depression by targeting miR-10b/BDNF in rats.	Curcumin	36-44	microRNA 10b	Rattus norvegicus	89-96
32627518-6	2020	GAS5 upregulation by curcumin could reduce miR-10b to compromise the BDNF mRNA levels.	Curcumin	21-29	microRNA 10b	Rattus norvegicus	43-50
32757994-12	2020	Moreover, curcumin exposure increased SOX6 expression through regulating miR-21-5p, and knockdown of SOX6 overturned curcumin-modulated suppression of HCC progression.	Curcumin	10-18	SRY-box transcription factor 6	Homo sapiens	38-42
32627518-7	2020	Taken together, these results revealed a novel mechanism of curcumin on PSD through the GAS5/miR-10b/BDNF regulatory axis.	Curcumin	60-68	microRNA 10b	Rattus norvegicus	93-100
32124937-0	2020	Curcumin exerts protective effects against hypoxia-reoxygenation injury via the enhancement of apurinic/apyrimidinic endonuclease 1 in SH-SY5Y cells: Involvement of the PI3K/AKT pathway.	Curcumin	0-8	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	95-131
32124937-4	2020	Therefore, the aim of the present study was to investigate whether curcumin alleviates oxygen-glucose deprivation/reperfusion (OGD/R)-induced SH-SY5Y cell injury, which serves as an in vitro model of cerebral I/R injury, by regulating APE1.	Curcumin	67-75	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	235-239
32124937-7	2020	However, APE1 knockdown by siRNA transfection markedly abrogated the protective effects of curcumin against OGD/R-induced cytotoxicity, apoptosis and oxidative stress, as illustrated by the decreases in reactive oxygen species production and NADPH oxidase 2 expression, and the increase in superoxide dismutase activity and glutathione levels in SH-SY5Y cells.	Curcumin	91-99	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	9-13
32228565-5	2020	We evaluated the effects of UPM and/or curcumin on the expression of phosphorylated ERK, Nrf2, HO-1, and SOD2 in fibroblasts by Western blotting.	Curcumin	39-47	superoxide dismutase 2	Homo sapiens	105-109
32228565-10	2020	Nrf2 production was also promoted to increase the expression of HO-1 and SOD2 by curcumin.	Curcumin	81-89	superoxide dismutase 2	Homo sapiens	73-77
32213933-8	2020	Dietary-added 200 mg/kg curcumin decreased concentrations of MDA and PC and improved the activities of catalase, superoxide dismutase (SOD) and peroxidase as compared to the IUGR group (p < 0.05).	Curcumin	24-32	catalase	Sus scrofa	103-111
32213933-9	2020	Additionally, dietary curcumin enhanced protein (NQO1) and mRNA expression of genes (Nrf2, NQO1, gamma-glutamyltransferase 1 (GGT1), heme oxygenase-1 (HO-1), glutathione S-transferase (GST) and catalase (CAT)) as compared to the IUGR group (p < 0.05).	Curcumin	22-30	heme oxygenase 1	Sus scrofa	133-149
32207596-9	2022	After treatment with low dose curcumin, the level of miRNA-146a in APP/PS1 mice decreased significantly, and the expression of A beta and APP/PS1 in temporal lobe of mice detected by Western blot decreased significantly, the levels of IL-1 beta and iNOS protein decreased significantly, and the protein of CFH increased signifanctly.	Curcumin	30-38	complement component factor h	Mus musculus	306-309
32207596-11	2022	Low dose curcumin can significantly reduce the level of neuropro-inflammatory miR-146A, up-regulate the expression of CFH protein, inhibit the phenotype of M1 microglia, and play a role in the treatment of AD by promoting the phagocytosis and clearance mechanism of A beta.	Curcumin	9-17	complement component factor h	Mus musculus	118-121
32184643-12	2020	The autophagy-related proteins LC3, p62, Beclin1, UVRAG and ATG5 were significantly affected in DN mice by curcumin, along with reducing expression of pro-apoptotic protein Bax and caspase-3 and increasing anti-apoptotic protein Bcl-2.	Curcumin	107-115	autophagy related 5	Mus musculus	60-64
32098449-0	2020	A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity in Vitro.	Curcumin	2-10	transcription factor EB	Homo sapiens	32-36
32098449-3	2020	In this study, a curcumin derivative, named E4, was identified as a potent TFEB activator.	Curcumin	17-25	transcription factor EB	Homo sapiens	75-79
32071296-7	2020	Moreover, autophagy enhancers, Torin1 (an mTOR-dependent TFEB/autophagy enhancer) and curcumin analog C1 (a TFEB-dependent and mTOR-independent autophagy enhancer), significantly rescued 6-OHDA/AA-induced cell death in SH-SY5Y cells, iPSC-derived DA neurons and mice nigral DA neurons.	Curcumin	86-94	transcription factor EB	Homo sapiens	108-112
32061917-6	2020	RESULTS: CUR and CIP treatment prevented the S. aureus-induced mouse mastitis increase the levels of IL-2, IL-10, and IFN-gamma and decrease levels of IL-6, IL-8, and TNF-alpha.	Curcumin	9-12	chemokine (C-X-C motif) ligand 15	Mus musculus	157-161
32061917-9	2020	CONCLUSION: These results indicated that CUR is superior to CIP in the prevention of mastitis, and the mechanism may be that the curative effect of CUR inhibits TLR-2 mediated NF-kappaB signaling pathway in mouse mastitis.	Curcumin	148-151	toll-like receptor 2	Mus musculus	161-166
31815784-6	2020	RECENT FINDINGS: Recent approaches, in animal models or in humans, use synthetic GLP-1 receptor agonists, a centrally administered antibody neutralizing GIP receptor, curcumin, compound being active on nesfatin, resveratrol (antiinflammatory agent), and Ginseg, both of them acting on nesfatin, a cholecystokinin receptor analogue, and finally coffee functioning on YY peptide.	Curcumin	167-175	glucagon like peptide 1 receptor	Homo sapiens	81-95
32245324-9	2020	Pre-treatment with curcumin, DPI and NAC inhibited TGF-beta-induced IL-6 (p=0.04) and TNF-alpha (p=0.001) mRNA expression, Smad2L phosphorylation (p=0.02) and ROS production (0.03).	Curcumin	19-27	transforming growth factor alpha	Homo sapiens	51-59
32245324-10	2020	Pharmacological inhibition by Curcumin blocks TGF-beta-induced ROS production, Smad2L phosphorylation, and IL-6 and TNF-alpha mRNA expression in human VSMCs.	Curcumin	30-38	transforming growth factor alpha	Homo sapiens	46-54
32210689-1	2020	The current study was aimed to study the effect of curcumin on the expression levels of brain glucose transporter 1 protein (GLUT1) and femoral muscle glucose transporter 4 protein (GLUT4), in addition to study its possible therapeutic role in ameliorating insulin resistance and the metabolic disturbance in the obese and type 2 diabetic male albino Wistar rat model.	Curcumin	51-59	solute carrier family 2 member 1	Rattus norvegicus	125-130
32025502-7	2020	Co-exposure of flies to Cu2+ and Curcumin prevented mortality, inhibited AChE activity and restored dopamine to normal levels (p &lt; 0.05).	Curcumin	33-41	Acetylcholine esterase	Drosophila melanogaster	73-77
31963896-6	2020	We have also looked at the ability of curcumin to interfere with the HSP60/HSP10 folding machinery.	Curcumin	38-46	heat shock protein family E (Hsp10) member 1	Homo sapiens	75-80
32021440-2	2020	Allylated monocarbonyl analogs of curcumin (MACs) have been reported to selectively inhibit a broad range of human cancers including gastric cancer.	Curcumin	34-42	myristoylated alanine rich protein kinase C substrate	Homo sapiens	44-48
31902919-0	2020	The Synthetic Curcumin Derivative CNB-001 Attenuates Thrombin-Stimulated Microglial Inflammation by Inhibiting the ERK and p38 MAPK Pathways.	Curcumin	14-22	mitogen activated protein kinase 14	Rattus norvegicus	123-126
31714633-4	2020	A significant increase in lipid peroxidation, nitric oxide and decreased activity of AChE, reduced glutathione, superoxide dismutase and catalase were observed in rotenone-treated mice while co-treatment of curcumin and MTC with rotenone significantly increased AChE activity and protected against rotenone-induced oxidative damage.	Curcumin	207-215	acetylcholinesterase	Mus musculus	85-89
31714633-4	2020	A significant increase in lipid peroxidation, nitric oxide and decreased activity of AChE, reduced glutathione, superoxide dismutase and catalase were observed in rotenone-treated mice while co-treatment of curcumin and MTC with rotenone significantly increased AChE activity and protected against rotenone-induced oxidative damage.	Curcumin	207-215	acetylcholinesterase	Mus musculus	262-266
31709586-4	2020	In addition, followed by the preservation of histo-architectures of the epididymis, testes, and brain in the rats treated with CPA, curcumin helped in increasing the sperm quality and quantity and suppressing both the inflammatory indices and the activities of caspase-3, while pretreatment with curcumin gave a better result than posttreatment with curcumin.	Curcumin	132-140	caspase 3	Rattus norvegicus	261-270
31887796-0	2020	Curcumin Inhibits the Proliferation, Migration, Invasion, and Apoptosis of Diffuse Large B-Cell Lymphoma Cell Line by Regulating MiR-21/VHL Axis.	Curcumin	0-8	von Hippel-Lindau tumor suppressor	Homo sapiens	136-139
31887796-12	2020	Moreover, curcumin exerted its regulatory effects on SU-DHL-8 cells by VHL.	Curcumin	10-18	von Hippel-Lindau tumor suppressor	Homo sapiens	71-74
31887796-13	2020	CONCLUSION: Curcumin exerted its anti-proliferation, anti-migration, anti-invasion, and pro-apoptosis functions, at least partly, by repressing miR-21 and regulating VHL expression in DLBCL cell line.	Curcumin	12-20	von Hippel-Lindau tumor suppressor	Homo sapiens	166-169
31878265-0	2019	Curcumin Alleviates IUGR Jejunum Damage by Increasing Antioxidant Capacity through Nrf2/Keap1 Pathway in Growing Pigs.	Curcumin	0-8	kelch like ECH associated protein 1	Sus scrofa	88-93
31878265-8	2019	In conclusion, dietary supplementation with 200 mg/kg curcumin can alleviate jejunum damage in IUGR growing pigs, through Nrf2/Keap1 pathway.	Curcumin	54-62	kelch like ECH associated protein 1	Sus scrofa	127-132
31530203-3	2019	Results: DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex.	Curcumin	95-103	desmocollin 3	Homo sapiens	9-12
31590042-14	2019	Curcumin treatment switched the M1 pro-inflammatory phenotype to the M2 anti-inflammatory phenotype by decreasing the expression of M1 markers (i.e., iNOS, IL-1beta, IL-6, and CD16/32) and elevating the expression of M2 markers (i.e., arginase 1, IL-4, IL-10, and CD206).	Curcumin	0-8	arginase, liver	Mus musculus	235-245
31807190-13	2019	Western blot analysis revealed that ABCC2 protein expression increased, and DCK, TK1 and TK2 expression decreased following co-treatment of T24-GCB cells with GCB + curcumin or resveratrol compared with GCB alone.	Curcumin	165-173	deoxycytidine kinase	Homo sapiens	76-79
31807190-13	2019	Western blot analysis revealed that ABCC2 protein expression increased, and DCK, TK1 and TK2 expression decreased following co-treatment of T24-GCB cells with GCB + curcumin or resveratrol compared with GCB alone.	Curcumin	165-173	thymidine kinase 2	Homo sapiens	89-92
31819373-0	2019	Delivery Of Curcumin Nanoliposomes Using Surface Modified With CD133 Aptamers For Prostate Cancer.	Curcumin	12-20	prominin 1	Homo sapiens	63-68
31819373-1	2019	Aim: The aim of this study was to characterize curcumin (CUR)-loaded CD133 aptamer A15 liposomes for their antitumor activity in vitro and in vivo.	Curcumin	47-55	prominin 1	Homo sapiens	69-74
31819373-1	2019	Aim: The aim of this study was to characterize curcumin (CUR)-loaded CD133 aptamer A15 liposomes for their antitumor activity in vitro and in vivo.	Curcumin	57-60	prominin 1	Homo sapiens	69-74
31703744-0	2019	Curcumin derivative WZ35 inhibits tumor cell growth via ROS-YAP-JNK signaling pathway in breast cancer.	Curcumin	0-8	Yes1 associated transcriptional regulator	Homo sapiens	60-63
31694300-0	2019	Curcumin Ameliorates Lead-Induced Hepatotoxicity by Suppressing Oxidative Stress and Inflammation, and Modulating Akt/GSK-3beta Signaling Pathway.	Curcumin	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	118-127
31694300-8	2019	CUR and/or AA ameliorated liver function, prevented tissue injury, and suppressed oxidative stress, DNA damage, NF-kappaB, JNK and caspase-3.	Curcumin	0-3	caspase 3	Rattus norvegicus	131-140
31694300-9	2019	In addition, CUR and/or AA activated Akt and inhibited GSK-3beta in Pb(II)-induced rats.	Curcumin	13-16	glycogen synthase kinase 3 beta	Rattus norvegicus	55-64
31694300-10	2019	In conclusion, CUR prevents Pb(II) hepatotoxicity via attenuation of oxidative injury and inflammation, activation of Akt and inhibition of GSK-3beta.	Curcumin	15-18	glycogen synthase kinase 3 beta	Rattus norvegicus	140-149
31016760-7	2019	We found that curcumin treatment significantly reduced HMEC-1 cells viability, migration, and the protein levels of MMP-2, MMP-9, and vascular endothelial growth factor (VEGF) in the presence or absence of ox-LDL.	Curcumin	14-22	matrix metallopeptidase 2	Homo sapiens	116-121
31016760-11	2019	And also, VEGF was a target gene of miR-126, and curcumin could inhibit the activation of PI3K/AKT JAK2/STAT5 signaling pathways via miR-126.	Curcumin	49-57	Janus kinase 2	Homo sapiens	99-103
31016760-13	2019	To sum up, curcumin exerted potent anti-AS property possibly via upregulating miR-126 and thereby inhibiting PI3K/AKT and JAK2/STAT5 signaling pathways.	Curcumin	11-19	Janus kinase 2	Homo sapiens	122-126
31608620-11	2019	The presence of POPC or total brain lipid extract vesicles prevented the curcumin from inhibiting htt fibril formation.	Curcumin	73-81	huntingtin	Homo sapiens	98-101
31720046-6	2019	The results revealed that curcumin administered daily significantly increased CXCR5+B-cell lymphoma 6+ TFH cells and CD95+GL-7+ germinal center (GC) B cells in draining lymph nodes.	Curcumin	26-34	chemokine (C-X-C motif) receptor 5	Mus musculus	78-83
32337261-7	2020	On the other hand, curcumin downregulated the EMT of LECs through blocking the TGF-beta/Smad pathway and interfering Notch pathway which play important roles in PCO.	Curcumin	19-27	transforming growth factor alpha	Homo sapiens	79-87
31958483-0	2020	The curcumin analogue WZ35 affects glycolysis inhibition of gastric cancer cells through ROS-YAP-JNK pathway.	Curcumin	4-12	Yes1 associated transcriptional regulator	Homo sapiens	93-96
31923486-1	2020	In this manuscript, lysozyme/kappa-carrageenan (LYS-CRG) complexes were prepared and used to encapsulate curcumin.	Curcumin	105-113	chromodomain helicase DNA binding protein 7	Homo sapiens	52-55
31923486-2	2020	The LYS-CRG complexes demonstrate good encapsulation of curcumin (CUR), and the encapsulation efficiency (EE) and loading capacity (LC) reach 96.2% and 2.31%, respectively.	Curcumin	56-64	chromodomain helicase DNA binding protein 7	Homo sapiens	8-11
31923486-2	2020	The LYS-CRG complexes demonstrate good encapsulation of curcumin (CUR), and the encapsulation efficiency (EE) and loading capacity (LC) reach 96.2% and 2.31%, respectively.	Curcumin	66-69	chromodomain helicase DNA binding protein 7	Homo sapiens	8-11
31923486-4	2020	The LYS-CRG complexes could effectively improve the storage stability of CUR and increase its retention rate.	Curcumin	73-76	chromodomain helicase DNA binding protein 7	Homo sapiens	8-11
31923486-5	2020	In simulated gastric fluid, only 17.91% CUR in the CUR-LYS-CRG complex nanoparticles is released in 3 h, while in the simulated intestinal fluid, the CUR release rate quickly reaches 62.56% in 1.5 h. The release rate tends to be stable within 1.5 h to 3 h and the final release rate reaches 67.23%, suggesting that the formation of CUR-LYS-CRG complex nanoparticles does not affect CUR release in the simulated intestinal fluid.	Curcumin	40-43	chromodomain helicase DNA binding protein 7	Homo sapiens	59-62
31923486-5	2020	In simulated gastric fluid, only 17.91% CUR in the CUR-LYS-CRG complex nanoparticles is released in 3 h, while in the simulated intestinal fluid, the CUR release rate quickly reaches 62.56% in 1.5 h. The release rate tends to be stable within 1.5 h to 3 h and the final release rate reaches 67.23%, suggesting that the formation of CUR-LYS-CRG complex nanoparticles does not affect CUR release in the simulated intestinal fluid.	Curcumin	51-54	chromodomain helicase DNA binding protein 7	Homo sapiens	59-62
31923486-5	2020	In simulated gastric fluid, only 17.91% CUR in the CUR-LYS-CRG complex nanoparticles is released in 3 h, while in the simulated intestinal fluid, the CUR release rate quickly reaches 62.56% in 1.5 h. The release rate tends to be stable within 1.5 h to 3 h and the final release rate reaches 67.23%, suggesting that the formation of CUR-LYS-CRG complex nanoparticles does not affect CUR release in the simulated intestinal fluid.	Curcumin	51-54	chromodomain helicase DNA binding protein 7	Homo sapiens	340-343
31923486-5	2020	In simulated gastric fluid, only 17.91% CUR in the CUR-LYS-CRG complex nanoparticles is released in 3 h, while in the simulated intestinal fluid, the CUR release rate quickly reaches 62.56% in 1.5 h. The release rate tends to be stable within 1.5 h to 3 h and the final release rate reaches 67.23%, suggesting that the formation of CUR-LYS-CRG complex nanoparticles does not affect CUR release in the simulated intestinal fluid.	Curcumin	51-54	chromodomain helicase DNA binding protein 7	Homo sapiens	59-62
31923486-5	2020	In simulated gastric fluid, only 17.91% CUR in the CUR-LYS-CRG complex nanoparticles is released in 3 h, while in the simulated intestinal fluid, the CUR release rate quickly reaches 62.56% in 1.5 h. The release rate tends to be stable within 1.5 h to 3 h and the final release rate reaches 67.23%, suggesting that the formation of CUR-LYS-CRG complex nanoparticles does not affect CUR release in the simulated intestinal fluid.	Curcumin	51-54	chromodomain helicase DNA binding protein 7	Homo sapiens	340-343
31923486-5	2020	In simulated gastric fluid, only 17.91% CUR in the CUR-LYS-CRG complex nanoparticles is released in 3 h, while in the simulated intestinal fluid, the CUR release rate quickly reaches 62.56% in 1.5 h. The release rate tends to be stable within 1.5 h to 3 h and the final release rate reaches 67.23%, suggesting that the formation of CUR-LYS-CRG complex nanoparticles does not affect CUR release in the simulated intestinal fluid.	Curcumin	51-54	chromodomain helicase DNA binding protein 7	Homo sapiens	59-62
31923486-5	2020	In simulated gastric fluid, only 17.91% CUR in the CUR-LYS-CRG complex nanoparticles is released in 3 h, while in the simulated intestinal fluid, the CUR release rate quickly reaches 62.56% in 1.5 h. The release rate tends to be stable within 1.5 h to 3 h and the final release rate reaches 67.23%, suggesting that the formation of CUR-LYS-CRG complex nanoparticles does not affect CUR release in the simulated intestinal fluid.	Curcumin	51-54	chromodomain helicase DNA binding protein 7	Homo sapiens	340-343
31923486-5	2020	In simulated gastric fluid, only 17.91% CUR in the CUR-LYS-CRG complex nanoparticles is released in 3 h, while in the simulated intestinal fluid, the CUR release rate quickly reaches 62.56% in 1.5 h. The release rate tends to be stable within 1.5 h to 3 h and the final release rate reaches 67.23%, suggesting that the formation of CUR-LYS-CRG complex nanoparticles does not affect CUR release in the simulated intestinal fluid.	Curcumin	51-54	chromodomain helicase DNA binding protein 7	Homo sapiens	59-62
31923486-5	2020	In simulated gastric fluid, only 17.91% CUR in the CUR-LYS-CRG complex nanoparticles is released in 3 h, while in the simulated intestinal fluid, the CUR release rate quickly reaches 62.56% in 1.5 h. The release rate tends to be stable within 1.5 h to 3 h and the final release rate reaches 67.23%, suggesting that the formation of CUR-LYS-CRG complex nanoparticles does not affect CUR release in the simulated intestinal fluid.	Curcumin	51-54	chromodomain helicase DNA binding protein 7	Homo sapiens	340-343
31612257-9	2020	Cisplatin-activated Hh signaling which was blocked by both Ars and curcumin as demonstrated by decreased mRNA levels of Shh, Smo, and Ptch and suppressed renal Gli1 and Gli2 protein levels.	Curcumin	67-75	patched 1	Rattus norvegicus	134-138
31612257-9	2020	Cisplatin-activated Hh signaling which was blocked by both Ars and curcumin as demonstrated by decreased mRNA levels of Shh, Smo, and Ptch and suppressed renal Gli1 and Gli2 protein levels.	Curcumin	67-75	GLI family zinc finger 1	Rattus norvegicus	160-164
32161501-1	2020	Purpose: This study was aimed to explore the anti-tumor effect of curcumin on breast cancer (BC) and the underlying mechanism involving Tafazzin (TAZ)/Yes-associated protein (YAP) axis.	Curcumin	66-74	Yes1 associated transcriptional regulator	Homo sapiens	175-178
32161501-7	2020	Curcumin decreased the protein expression of TAZ and YAP in MCF-7 and MDA-MB-231 cells.	Curcumin	0-8	Yes1 associated transcriptional regulator	Homo sapiens	53-56
32161501-8	2020	Overexpression of YAP reversed the anti-tumor effect of curcumin on MDA-MB-231 cells.	Curcumin	56-64	Yes1 associated transcriptional regulator	Homo sapiens	18-21
32161501-9	2020	In addition, curcumin (100, 200 and 300 mg/kg/d) inhibited the growth of tumor xenografts in mice, and down-regulated the protein expression of TAZ and YAP in tumor xenografts.	Curcumin	13-21	yes-associated protein 1	Mus musculus	152-155
32161501-11	2020	Conclusion: Curcumin inhibited the tumorigenesis of BC by blocking TAZ/YAP axis.	Curcumin	12-20	yes-associated protein 1	Mus musculus	71-74
32175381-4	2020	However, whether curcumin could effectively inhibit inflammation through the suppression of HMGB1 production or HMGB1-mediated inflammatory responses in Abeta-activated microglia is still unclear.	Curcumin	17-25	high mobility group box 1	Homo sapiens	92-97
32175381-4	2020	However, whether curcumin could effectively inhibit inflammation through the suppression of HMGB1 production or HMGB1-mediated inflammatory responses in Abeta-activated microglia is still unclear.	Curcumin	17-25	high mobility group box 1	Homo sapiens	112-117
31816386-11	2020	Consistent with in vitro data, dietary curcumin protected intestinal barrier function, improved redox status, alleviated mitochondrial damage, triggered mitophagy and influenced AMPK-TFEB signal pathway in a well-established pig oxidative stress model by challenging with diquat.	Curcumin	39-47	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	178-182
31816386-11	2020	Consistent with in vitro data, dietary curcumin protected intestinal barrier function, improved redox status, alleviated mitochondrial damage, triggered mitophagy and influenced AMPK-TFEB signal pathway in a well-established pig oxidative stress model by challenging with diquat.	Curcumin	39-47	transcription factor EB	Sus scrofa	183-187
31816386-12	2020	Taken together, these results unveil that curcumin ameliorates oxidative stress, enhances intestinal barrier function and mitochondrial function via the induction of Parkin dependent mitophagy through AMPK activation and subsequent TFEB nuclear translocation.	Curcumin	42-50	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	201-205
31816386-12	2020	Taken together, these results unveil that curcumin ameliorates oxidative stress, enhances intestinal barrier function and mitochondrial function via the induction of Parkin dependent mitophagy through AMPK activation and subsequent TFEB nuclear translocation.	Curcumin	42-50	transcription factor EB	Sus scrofa	232-236
32245324-3	2020	In the present study, we investigate the effect of curcumin on modulating the pro-inflammatory action of TGF-beta in human vascular smooth muscle cells (VSMCs) and its molecular mechanisms.	Curcumin	51-59	transforming growth factor alpha	Homo sapiens	105-113
32010088-6	2019	Finally, ebselen was found to sensitize S. aureus to curcumin, which may be due to their synergistic effects in inhibiting bacterial TrxR.	Curcumin	53-61	AT695_RS13830	Staphylococcus aureus	133-137
32673649-10	2020	RESULTS AND CONCLUSIONS: Curcumin reduced liver damage, oxidative stress, fibrosis, and restored normal activity of MMP-9 and MMP-2.	Curcumin	25-33	matrix metallopeptidase 2	Rattus norvegicus	126-131
31538907-0	2020	Effect of Curcumin on Serum Cathepsin D in Patients with Metabolic Syndrome.	Curcumin	10-18	cathepsin D	Homo sapiens	28-39
31538907-3	2020	In current study, we aimed to investigate the effect of curcumin on serum cathepsin D in patients with MetS.	Curcumin	56-64	cathepsin D	Homo sapiens	74-85
31590861-2	2020	In this context, this study evaluated the effect of lecithin on the characteristics of chitosan (CHI) and chondroitin sulfate (CS) nanoparticles, when applied in curcumin (Curc) release.	Curcumin	162-170	citrate synthase	Homo sapiens	127-129
31590861-2	2020	In this context, this study evaluated the effect of lecithin on the characteristics of chitosan (CHI) and chondroitin sulfate (CS) nanoparticles, when applied in curcumin (Curc) release.	Curcumin	172-176	citrate synthase	Homo sapiens	127-129
31590861-6	2020	The final characteristics of NPs were directly influenced by lecithin addition, exhibiting enhanced encapsulation efficiency of curcumin (131.8 mug curcumin per mg CHI/CS/Lecithin/Curc NPs).	Curcumin	128-136	citrate synthase	Homo sapiens	164-170
31590861-8	2020	However, the release of curcumin in buffer solution at pH 7.4 was achieved faster in CHI/CS/Lecithin/Curc NPs than in CHI/CS/Curc NPs.	Curcumin	24-32	citrate synthase	Homo sapiens	85-91
31590861-8	2020	However, the release of curcumin in buffer solution at pH 7.4 was achieved faster in CHI/CS/Lecithin/Curc NPs than in CHI/CS/Curc NPs.	Curcumin	24-32	citrate synthase	Homo sapiens	118-124
31897118-0	2020	Curcumin increases the sensitivity of K562/DOX cells to doxorubicin by targeting S100 calcium-binding protein A8 and P-glycoprotein.	Curcumin	0-8	S100 calcium binding protein A8	Homo sapiens	81-112
31897118-6	2020	Western blot analysis revealed that curcumin treatment caused a downregulation of the expression of P-glycoprotein (P-gp) and S100A8 in a dose- and time-dependent manner.	Curcumin	36-44	S100 calcium binding protein A8	Homo sapiens	126-132
31897118-10	2020	In conclusion, the present study suggested that inhibition of S100A8 expression increased DOX-induced apoptosis, and curcumin acted independently on S100A8 and P-gp to exert its drug resistance reversal effects.	Curcumin	117-125	S100 calcium binding protein A8	Homo sapiens	149-155
31976028-5	2019	CUR treatment induced autophagy and enhanced autophagic flux in an AMPK/mTOR/ULK1-dependent manner.	Curcumin	0-3	unc-51 like autophagy activating kinase 1	Homo sapiens	77-81
31584928-0	2019	Curcumin Inhibits Cell Viability and Increases Apoptosis of SW620 Human Colon Adenocarcinoma Cells via the Caudal Type Homeobox-2 (CDX2)/Wnt/beta-Catenin Pathway.	Curcumin	0-8	Wnt family member 3A	Homo sapiens	137-140
31584928-9	2019	RESULTS Curcumin reduced cell viability and increased apoptosis of SW620 human colonic adenocarcinoma cells in a dose-dependent way, and increased the expression of CDX2 but decreased ss-catenin nuclear translocation and the expression of Wnt3a, c-Myc, survivin, and cyclin D1.	Curcumin	8-16	Wnt family member 3A	Homo sapiens	239-244
31584928-9	2019	RESULTS Curcumin reduced cell viability and increased apoptosis of SW620 human colonic adenocarcinoma cells in a dose-dependent way, and increased the expression of CDX2 but decreased ss-catenin nuclear translocation and the expression of Wnt3a, c-Myc, survivin, and cyclin D1.	Curcumin	8-16	cyclin D1	Homo sapiens	267-276
31584928-12	2019	CONCLUSIONS Curcumin reduced cell viability and increased apoptosis in SW620 human colonic adenocarcinoma cells by restoring CDX2, which inhibited the Wnt/ss-catenin signaling pathway.	Curcumin	12-20	Wnt family member 3A	Homo sapiens	151-154
31027431-6	2019	RESULTS: Our study showed that the chrysin-curcumin-loaded nanofibres have anti-inflammatory properties in several stages of the wound-healing process by affecting the IL-6, MMP-2, TIMP-1, TIMP-2 and iNOS gene expression.	Curcumin	43-51	matrix metallopeptidase 2	Rattus norvegicus	174-179
32757994-12	2020	Moreover, curcumin exposure increased SOX6 expression through regulating miR-21-5p, and knockdown of SOX6 overturned curcumin-modulated suppression of HCC progression.	Curcumin	117-125	SRY-box transcription factor 6	Homo sapiens	101-105
31470039-4	2019	We quantified curcumin-induced release of glucagon-like peptide 1 (GLP-1) from mouse STC-1 cells that represent enteroendocrine L-cells as a major source of this anti-diabetic hormone.	Curcumin	14-22	glucagon	Mus musculus	42-65
31470039-4	2019	We quantified curcumin-induced release of glucagon-like peptide 1 (GLP-1) from mouse STC-1 cells that represent enteroendocrine L-cells as a major source of this anti-diabetic hormone.	Curcumin	14-22	glucagon	Mus musculus	67-72
31470039-5	2019	Curcumin induced secretion of GLP-1 in a dose-dependent manner.	Curcumin	0-8	glucagon	Mus musculus	30-35
32757994-13	2020	Conclusions: Curcumin repressed proliferation, migration, and invasion of HCC cells by regulating miR-21-5p and SOX6, indicating the promisingly pharmacological effect of curcumin in HCC.	Curcumin	13-21	SRY-box transcription factor 6	Homo sapiens	112-116
31470039-7	2019	Chromatographically isolated spiroepoxide, an unstable oxidative metabolite of curcumin with anti-inflammatory activity, also induced secretion of GLP-1.	Curcumin	79-87	glucagon	Mus musculus	147-152
31539270-0	2019	Curcumin Promoted miR-34a Expression and Suppressed Proliferation of Gastric Cancer Cells.	Curcumin	0-8	microRNA 34a	Homo sapiens	18-25
31539270-1	2019	Background: To investigate the effects of curcumin on miR-34a and proliferation of gastric cancer cells.	Curcumin	42-50	microRNA 34a	Homo sapiens	54-61
31470039-9	2019	GLP-1 secretion induced by curcumin and its oxidative degradation products was associated with activation of PKC, ERK, and CaM kinase II.	Curcumin	27-35	glucagon	Mus musculus	0-5
31539270-7	2019	Results: The results showed that curcumin markedly increased the content of miR-34a microRNA (mRNA) in SGC-7901 cells, inhibited proliferation, migration, and invasion of SGC-7901 cells, when compared to control group (p &lt; 0.05).	Curcumin	33-41	microRNA 34a	Homo sapiens	76-83
32757994-13	2020	Conclusions: Curcumin repressed proliferation, migration, and invasion of HCC cells by regulating miR-21-5p and SOX6, indicating the promisingly pharmacological effect of curcumin in HCC.	Curcumin	171-179	SRY-box transcription factor 6	Homo sapiens	112-116
31539270-8	2019	Compared with control group, curcumin significantly inhibited cell cycle progression in G0/G1-S phase, increased the cell number of G0/G1 phase, and downregulated the Bcl-2, CDK4, and cyclin D1 protein expression in cells and tissues (p &lt; 0.05).	Curcumin	29-37	cyclin dependent kinase 4	Homo sapiens	174-178
31539270-8	2019	Compared with control group, curcumin significantly inhibited cell cycle progression in G0/G1-S phase, increased the cell number of G0/G1 phase, and downregulated the Bcl-2, CDK4, and cyclin D1 protein expression in cells and tissues (p &lt; 0.05).	Curcumin	29-37	cyclin D1	Homo sapiens	184-193
31569380-9	2019	Results showed the viability of preadipocytes was significantly decreased by treatment with 30 microM curcumin, a concentration that caused apoptosis in preadipocytes, as assessed by the TUNEL assay, and caused activation of caspases 8, 9, and 3.	Curcumin	102-110	caspase 8	Homo sapiens	225-245
31539270-9	2019	After transfection of miR-34a agomir or antagomir into cells it was found that miR-34a agomir and curcumin had similar effects on resisting malignant biological behavior.	Curcumin	98-106	microRNA 34a	Homo sapiens	22-29
32535538-0	2020	Effect of curcumin on IL-17A mediated pulmonary AMPK kinase/cyclooxygenase-2 expressions via activation of NFkappaB in bleomycin-induced acute lung injury in vivo.	Curcumin	10-18	prostaglandin-endoperoxide synthase 2	Mus musculus	60-76
32535538-4	2020	Immunofluorescence analysis reveals that the natural spice curcumin blocks the expressions of COX-2, NF-kappaB-p65, fibronectin (FBN), and expresses P-AMPKalpha in vivo.	Curcumin	59-67	cytochrome c oxidase II, mitochondrial	Mus musculus	94-99
32535538-6	2020	mRNA expressions showed reduced expressions of PDGFA, PDGFB, CTGF, IGF1, NFkappaB1, NFkappaB2, MMP-3, MMP-9, and MMP-14 on curcumin treatment.	Curcumin	123-131	platelet derived growth factor, alpha	Mus musculus	47-52
31664615-0	2019	Curcumin Induces Endothelium-Dependent Relaxation by Activating Endothelial TRPV4 Channels.	Curcumin	0-8	transient receptor potential cation channel subfamily V member 4	Homo sapiens	76-81
31664615-3	2019	In our study, fluorescent Ca2+ imaging in mesenteric arterial endothelial cells (MAECs) and overexpressed TRPV4 human embryonic kidney (HEK293) cells showed that curcumin dose-dependently stimulated Ca2+ influx.	Curcumin	162-170	transient receptor potential cation channel subfamily V member 4	Homo sapiens	106-111
31664615-4	2019	Whole-cell patch clamp proved that curcumin stimulated the TRPV4-mediated currents in TRPV4-HEK293 cells.	Curcumin	35-43	transient receptor potential cation channel subfamily V member 4	Homo sapiens	59-64
31482893-8	2019	The FTIR data showed appreciable conversion of beta-sheets into less aggregation-prone secondary structures for all three amylin-ligand ratios; however, the inhibition performance of curcumin overshadowed those of the other two inhibitors.	Curcumin	183-191	islet amyloid polypeptide	Homo sapiens	122-128
32535538-6	2020	mRNA expressions showed reduced expressions of PDGFA, PDGFB, CTGF, IGF1, NFkappaB1, NFkappaB2, MMP-3, MMP-9, and MMP-14 on curcumin treatment.	Curcumin	123-131	cellular communication network factor 2	Mus musculus	61-65
31664615-4	2019	Whole-cell patch clamp proved that curcumin stimulated the TRPV4-mediated currents in TRPV4-HEK293 cells.	Curcumin	35-43	transient receptor potential cation channel subfamily V member 4	Homo sapiens	86-91
31664615-6	2019	Molecular modeling and docking showed that the binding site of curcumin and TRPV4 was mainly in the amino acid sequence LYS340-LEU349 of TRPV4 protein.	Curcumin	63-71	transient receptor potential cation channel subfamily V member 4	Homo sapiens	76-81
32535538-6	2020	mRNA expressions showed reduced expressions of PDGFA, PDGFB, CTGF, IGF1, NFkappaB1, NFkappaB2, MMP-3, MMP-9, and MMP-14 on curcumin treatment.	Curcumin	123-131	insulin-like growth factor 1	Mus musculus	67-71
31664615-6	2019	Molecular modeling and docking showed that the binding site of curcumin and TRPV4 was mainly in the amino acid sequence LYS340-LEU349 of TRPV4 protein.	Curcumin	63-71	transient receptor potential cation channel subfamily V member 4	Homo sapiens	137-142
31664615-8	2019	Therefore, our results demonstrated that curcumin stimulates Ca2+ entry in endothelial cells and improves endothelium-dependent vessel relaxation by activating TRPV4 channels.	Curcumin	41-49	transient receptor potential cation channel subfamily V member 4	Homo sapiens	160-165
32535538-6	2020	mRNA expressions showed reduced expressions of PDGFA, PDGFB, CTGF, IGF1, NFkappaB1, NFkappaB2, MMP-3, MMP-9, and MMP-14 on curcumin treatment.	Curcumin	123-131	matrix metallopeptidase 9	Mus musculus	102-107
32535538-7	2020	Our study implicates a critical role of AMPKalpha/COX- 2 in the emergence of pulmonary fibrosis via exerting the potential role of curcumin as an adjuvant anti-inflammatory therapeutic for treating lung injury.	Curcumin	131-139	cytochrome c oxidase II, mitochondrial	Mus musculus	50-56
31514267-0	2019	The Therapeutic Effect of Curcumin in Quinolinic Acid-Induced Neurotoxicity in Rats is Associated with BDNF, ERK1/2, Nrf2, and Antioxidant Enzymes.	Curcumin	26-34	mitogen activated protein kinase 3	Rattus norvegicus	109-115
31514267-1	2019	In the present study we investigated the participation of brain-derived neurotropic factor (BDNF) on the activation of the mitogen activated protein kinase (MAPK) protein extracellular signal-regulated kinase-1/2 (ERK1/2) as a mechanism of curcumin (CUR) to provide an antioxidant defense system mediated by the nuclear factor erythroid 2-related factor 2 (Nrf2) in the neurotoxic model induced by quinolinic acid (QUIN).	Curcumin	240-248	mitogen activated protein kinase 3	Rattus norvegicus	157-161
31514267-1	2019	In the present study we investigated the participation of brain-derived neurotropic factor (BDNF) on the activation of the mitogen activated protein kinase (MAPK) protein extracellular signal-regulated kinase-1/2 (ERK1/2) as a mechanism of curcumin (CUR) to provide an antioxidant defense system mediated by the nuclear factor erythroid 2-related factor 2 (Nrf2) in the neurotoxic model induced by quinolinic acid (QUIN).	Curcumin	240-248	mitogen activated protein kinase 3	Rattus norvegicus	171-212
31514267-1	2019	In the present study we investigated the participation of brain-derived neurotropic factor (BDNF) on the activation of the mitogen activated protein kinase (MAPK) protein extracellular signal-regulated kinase-1/2 (ERK1/2) as a mechanism of curcumin (CUR) to provide an antioxidant defense system mediated by the nuclear factor erythroid 2-related factor 2 (Nrf2) in the neurotoxic model induced by quinolinic acid (QUIN).	Curcumin	240-248	mitogen activated protein kinase 3	Rattus norvegicus	214-220
31638219-13	2019	H/R injury-triggered ER stress and the MAPK signaling pathway were suppressed by Cur.	Curcumin	81-84	mitogen activated protein kinase 3	Rattus norvegicus	39-43
31638219-14	2019	These results demonstrated that Cur has a protective effect on cardiomyocytes via suppression of ER stress and the MAPK pathway.	Curcumin	32-35	mitogen activated protein kinase 3	Rattus norvegicus	115-119
32617134-8	2020	Further, curcumin-induced DNA demethylation of hGCCs was mediated by the damaged DNA repair-p53-p21/GADD45A-cyclin/CDK-Rb/E2F-DNMT1 axis.	Curcumin	9-17	growth arrest and DNA damage inducible alpha	Homo sapiens	100-107
32529309-5	2020	RESULTS: Curcumin demonstrated potent reversible inhibition of cytochrome P450 (CYP)3A4-mediated N-demethylation of imatinib and bosutinib and CYP2C8-mediated metabolism of imatinib with inhibitory constants (ki,u) of <=1.5 mumol.	Curcumin	9-17	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	143-149
31488728-5	2019	Curcumin treatment significantly increased the expression of Beclin1, Atg5, and Atg16L1, induced the formation of autophagosomes, and promoted autophagosome-lysosome fusion in N2a/APP695swe cells.	Curcumin	0-8	autophagy related 5	Mus musculus	70-74
31488728-6	2019	At the same time, curcumin promoted the expression of dynein, dynactin, and BICD2 as well as their binding to form the retrograde axonal transport molecular motor complex.	Curcumin	18-26	BICD cargo adaptor 2	Mus musculus	76-81
32405958-9	2020	Curcumin also prevented neuronal degeneration in different brain regions and reduced caspase-3 expression.	Curcumin	0-8	caspase 3	Rattus norvegicus	85-94
31488728-7	2019	Moreover, curcumin also increased the expression of the scaffolding proteins Rab7- interacting lysosomal protein (RILP) and huntingtin in N2a/APP695swe cells.	Curcumin	10-18	Rab interacting lysosomal protein	Mus musculus	77-112
31488728-7	2019	Moreover, curcumin also increased the expression of the scaffolding proteins Rab7- interacting lysosomal protein (RILP) and huntingtin in N2a/APP695swe cells.	Curcumin	10-18	Rab interacting lysosomal protein	Mus musculus	114-118
31530996-7	2019	Objective: To investigate whether curcumin can play a protective role against PM2.5-induced oxidative stress and inflammatory damage by inducing expression of the HO-1/CO/P38 MAPK pathway.	Curcumin	34-42	mitogen-activated protein kinase 14	Mus musculus	171-179
31530996-16	2019	The results showed that the expression of the HO-1/CO/P38 MAPK protein in the lung tissue was significantly increased in the curcumin intervention group compared with the PM2.5 treatment group, and it was statistically significant (P &lt; 0.05).	Curcumin	125-133	mitogen-activated protein kinase 14	Mus musculus	54-62
31530996-17	2019	Compared with the PM2.5 treatment group, the curcumin intervention group can reduce the amount of ALB, LDH, and ALP in BALF; reduce the levels of MDA, IL-1, and TNF-alpha in the lung tissue; and improve GSH-PX, T-AOC, and CAT levels, but there is no statistical difference (P &gt; 0.05).	Curcumin	45-53	albumin	Mus musculus	98-101
31530996-17	2019	Compared with the PM2.5 treatment group, the curcumin intervention group can reduce the amount of ALB, LDH, and ALP in BALF; reduce the levels of MDA, IL-1, and TNF-alpha in the lung tissue; and improve GSH-PX, T-AOC, and CAT levels, but there is no statistical difference (P &gt; 0.05).	Curcumin	45-53	interleukin 1 complex	Mus musculus	151-155
31530996-20	2019	The intervention of curcumin can further increase the expression of HO-1/CO/P38 MAPK.	Curcumin	20-28	mitogen-activated protein kinase 14	Mus musculus	76-84
31710976-0	2019	Curcumin inhibits proliferation and soluble collagen synthesis of NIH/3T3 cell line by modulation of miR-29a and via ERK1/2 and beta-catenin pathways.	Curcumin	0-8	microRNA 29a	Mus musculus	101-108
31710976-0	2019	Curcumin inhibits proliferation and soluble collagen synthesis of NIH/3T3 cell line by modulation of miR-29a and via ERK1/2 and beta-catenin pathways.	Curcumin	0-8	mitogen-activated protein kinase 3	Mus musculus	117-123
30957612-7	2019	Enhanced AMPK activation, accompanied with decreased HDAC4 and G6Pase expression (p &lt; 0.05) were partly contributed to the alleviation of GD mediated by curcumin.	Curcumin	156-164	glucose-6-phosphatase, catalytic	Mus musculus	63-69
31741405-8	2019	Furthermore, curcumin upregulated the expression of E-cadherin and LC3 proteins and downregulated the vimentin, TWIST1, p62, p-mTOR, p-Akt and P13K levels in DN rats and MPC5 cells.	Curcumin	13-21	annexin A3	Rattus norvegicus	67-70
31741405-8	2019	Furthermore, curcumin upregulated the expression of E-cadherin and LC3 proteins and downregulated the vimentin, TWIST1, p62, p-mTOR, p-Akt and P13K levels in DN rats and MPC5 cells.	Curcumin	13-21	vimentin	Rattus norvegicus	102-110
31741405-8	2019	Furthermore, curcumin upregulated the expression of E-cadherin and LC3 proteins and downregulated the vimentin, TWIST1, p62, p-mTOR, p-Akt and P13K levels in DN rats and MPC5 cells.	Curcumin	13-21	twist family bHLH transcription factor 1	Rattus norvegicus	112-118
31741405-8	2019	Furthermore, curcumin upregulated the expression of E-cadherin and LC3 proteins and downregulated the vimentin, TWIST1, p62, p-mTOR, p-Akt and P13K levels in DN rats and MPC5 cells.	Curcumin	13-21	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	120-123
31432177-10	2019	These data suggested that curcumin may control the EGFR and TLR4/MyD88 pathways to synergistically downregulate downstream cell cycle- and EMT-related regulators, in order to block cell proliferation and metastasis in NSCLC.	Curcumin	26-34	MYD88 innate immune signal transduction adaptor	Homo sapiens	65-70
31608620-10	2019	Here, we investigated if the presence of lipid vesicles altered the ability of EGCG or curcumin to modulate htt aggregation and influence the interaction of htt with lipid membranes.	Curcumin	87-95	huntingtin	Homo sapiens	108-111
32248350-4	2020	Molecular docking was used to predict binding models between curcumin derivatives and neuraminidase.	Curcumin	61-69	neuraminidase 1	Homo sapiens	86-99
32248350-6	2020	Neuraminidase activation assay showed that five active curcumin derivatives decreased H1N1-induced neuraminidase activation in MDCK cells.	Curcumin	55-63	neuraminidase 1	Homo sapiens	0-13
32248350-6	2020	Neuraminidase activation assay showed that five active curcumin derivatives decreased H1N1-induced neuraminidase activation in MDCK cells.	Curcumin	55-63	neuraminidase 1	Homo sapiens	99-112
31652632-3	2019	The SIL formulation is a dietary supplement that was designed leveraging the more bioavailable forms of ingredients with poor absorption, such as curcumin and quercetin.	Curcumin	146-154	STIL centriolar assembly protein	Homo sapiens	4-7
32248350-10	2020	These results indicate that curcumin derivatives inhibit IAV by blocking neuraminidase in the cellular model and curcumin also has anti-IAV activity in the animal model.	Curcumin	28-36	neuraminidase 1	Homo sapiens	73-86
31154107-9	2019	Depletion of p300 by siRNA or inhibition of p300 by curcumin attenuated Elovl3 trans-activation in prostate cancer cells.	Curcumin	52-60	E1A binding protein p300	Homo sapiens	44-48
31891282-0	2020	Post-treatment curcumin reduced ischemia-reperfusion-induced pulmonary injury via the Notch2/Hes-1 pathway.	Curcumin	15-23	hes family bHLH transcription factor 1	Homo sapiens	93-98
31028577-0	2019	Curcumin Modulates Paraquat-Induced Epithelial to Mesenchymal Transition by Regulating Transforming Growth Factor-beta (TGF-beta) in A549 Cells.	Curcumin	0-8	transforming growth factor alpha	Homo sapiens	120-128
31028577-8	2019	These results demonstrate that curcumin can regulate PQ-induced EMT by regulating the expression of TGF-beta.	Curcumin	31-39	transforming growth factor alpha	Homo sapiens	100-108
31466778-8	2019	The results of present study showed that heat stress curcumin treatment group had reduced inflammatory responses (IL-6, IL-1beta, TNF-alpha) as compared to HC and NC group.	Curcumin	53-61	lipopolysaccharide induced TNF factor	Gallus gallus	130-139
31595849-0	2019	Renoprotective effect of curcumin labelled on Mesoscale Nanoparticles (MNPs) on Renal Ischemia-Reperfusion Injury (RIRI) via the miR-146a/nNOS/NO/cGMP/PKG signaling pathway.	Curcumin	25-33	nitric oxide synthase 1	Homo sapiens	138-142
31581661-9	2019	TGF-beta signaling, including the androgen/TGF-beta inhibitor Prostate transmembrane protein androgen-induced 1 (PMEPA1), was the only pathway impacted by curcumin treatment after 48 h. Our findings also established that MYC Proto-Oncogene, basic helix-loop-helix (bHLH) Transcription Factor (MYC) signaling was down-regulated in curcumin-treated cell lines.	Curcumin	155-163	transforming growth factor alpha	Homo sapiens	0-8
31581661-9	2019	TGF-beta signaling, including the androgen/TGF-beta inhibitor Prostate transmembrane protein androgen-induced 1 (PMEPA1), was the only pathway impacted by curcumin treatment after 48 h. Our findings also established that MYC Proto-Oncogene, basic helix-loop-helix (bHLH) Transcription Factor (MYC) signaling was down-regulated in curcumin-treated cell lines.	Curcumin	330-338	transforming growth factor alpha	Homo sapiens	0-8
31369746-6	2019	Furthermore, pretreatment with E100 (10 mg/kg) the increased microglial activation, proinflammatory cytokines and expression of NF-kappaB, iNOS, and COX-2 in the cerebellum as well as the hippocampus (all P &lt; 0.05).	Curcumin	31-35	cytochrome c oxidase II, mitochondrial	Mus musculus	149-154
32126993-6	2020	Additionally, CUR,DMC, and BDMC induced the apoptosis of HOS cells through activation of Smad 2/3 or repression of Akt signaling pathway.	Curcumin	14-17	SMAD family member 2	Homo sapiens	89-97
31962379-0	2020	Incomplete Hydrolysis of Curcumin Conjugates by beta-Glucuronidase: Detection of Complex Conjugates in Plasma.	Curcumin	25-33	glucuronidase beta	Homo sapiens	48-66
31357126-4	2019	The crosslinked super-amphiphilic structure of PEZ-alt-PEG could not only enhance the thermodynamic stability of polymeric micelles, but it could also significantly improve the loading capacity of hydrophobic drugs, such as curcumin (CUR).	Curcumin	224-232	protein tyrosine phosphatase non-receptor type 14	Homo sapiens	47-50
31357126-4	2019	The crosslinked super-amphiphilic structure of PEZ-alt-PEG could not only enhance the thermodynamic stability of polymeric micelles, but it could also significantly improve the loading capacity of hydrophobic drugs, such as curcumin (CUR).	Curcumin	234-237	protein tyrosine phosphatase non-receptor type 14	Homo sapiens	47-50
31357126-6	2019	The use of PEZ-alt-PEG micellar nanocarriers remarkably improved the cellular uptake of CUR and therefore exhibited effective inhibitory activity on the growth of human hepatoma (HepG2) cells.	Curcumin	88-91	protein tyrosine phosphatase non-receptor type 14	Homo sapiens	11-14
31612395-3	2019	Our previous studies have shown that curcumin suppresses HSC activation through increasing peroxisome proliferator-activated receptor, gamma (PPARgamma) and 5" adenosine monophosphate-activated protein kinase (AMPK) activities.	Curcumin	37-45	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	160-208
31612395-3	2019	Our previous studies have shown that curcumin suppresses HSC activation through increasing peroxisome proliferator-activated receptor, gamma (PPARgamma) and 5" adenosine monophosphate-activated protein kinase (AMPK) activities.	Curcumin	37-45	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	210-214
31612395-5	2019	Now we showed that curcumin increased LD formation in activated HSCs and stimulated the expression of sterol regulatory element-binding protein and fatty acid synthase, and reduced the expression of adipose triglyceride lipase.	Curcumin	19-27	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	102-143
31612395-9	2019	Furthermore, inhibition of AMPK or PPARgamma activity blocked curcumin"s effect on Plin5 gene expression and LD formation.	Curcumin	62-70	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	27-31
31257466-10	2019	The expression levels of NICD, hairy and enhancer of split (Hes)-1, Hes-5 and hairy/enhancer-of-split related with YRPW motif protein 1 (Hey-1) were significantly decreased in H/R-treated cells following curcumin treatment.	Curcumin	204-212	hes family bHLH transcription factor 5	Rattus norvegicus	68-73
31257466-10	2019	The expression levels of NICD, hairy and enhancer of split (Hes)-1, Hes-5 and hairy/enhancer-of-split related with YRPW motif protein 1 (Hey-1) were significantly decreased in H/R-treated cells following curcumin treatment.	Curcumin	204-212	hes-related family bHLH transcription factor with YRPW motif 1	Rattus norvegicus	78-135
31257466-10	2019	The expression levels of NICD, hairy and enhancer of split (Hes)-1, Hes-5 and hairy/enhancer-of-split related with YRPW motif protein 1 (Hey-1) were significantly decreased in H/R-treated cells following curcumin treatment.	Curcumin	204-212	hes-related family bHLH transcription factor with YRPW motif 1	Rattus norvegicus	137-142
31264110-8	2019	Curcumin pre-treatment slightly ameliorated the MDA levels, NO levels, cytochrome c levels and caspase 3 activities in AlCI3-exposed synaptosomes, but these results were not statistically significant.	Curcumin	0-8	caspase 3	Rattus norvegicus	95-104
32020216-0	2020	Curcumin induces re-expression of BRCA1 and suppression of gamma synuclein by modulating DNA promoter methylation in breast cancer cell lines.	Curcumin	0-8	synuclein gamma	Homo sapiens	59-74
31264110-9	2019	Furthermore, curcumin post-treatment significantly improved oxidative damage and morphological alterations, and suppressed cytochrome c and caspase 3 activities.	Curcumin	13-21	caspase 3	Rattus norvegicus	140-149
31029908-9	2019	Meanwhile, curcumin alleviated the oxidative stress response via reducing MDA content and increasing SOD, CAT, GPx, GR and GSH levels in this animal model.	Curcumin	11-19	peroxiredoxin 6 pseudogene 2	Mus musculus	111-114
31029908-11	2019	Curcumin also attenuated the high expression of IL-6, MCP-1, OPN, CD44, alpha-SMA, Collagen I and collagen fibril deposition, which were elevated by hyperoxaluria.	Curcumin	0-8	secreted phosphoprotein 1	Mus musculus	61-64
31998463-4	2019	The present study aimed to compare cyclin D1 (CCN D1) gene expression in hepatocellular carcinoma cell line (HUH7) when it is treated with nanomicelle curcumin and sorafenib.	Curcumin	151-159	cyclin D1	Homo sapiens	35-44
31998463-4	2019	The present study aimed to compare cyclin D1 (CCN D1) gene expression in hepatocellular carcinoma cell line (HUH7) when it is treated with nanomicelle curcumin and sorafenib.	Curcumin	151-159	cyclin D1	Homo sapiens	46-52
31998463-9	2019	Results: The expression of the CCN D1 gene was statistically significant (P&lt;0.001) at 289.31, 128 and 152.36 for sorafenib, nanomicelle curcumin and SNC (sorafenib-nanomicelle curcumin) respectively.	Curcumin	139-147	cyclin D1	Homo sapiens	31-37
31998463-9	2019	Results: The expression of the CCN D1 gene was statistically significant (P&lt;0.001) at 289.31, 128 and 152.36 for sorafenib, nanomicelle curcumin and SNC (sorafenib-nanomicelle curcumin) respectively.	Curcumin	179-187	cyclin D1	Homo sapiens	31-37
31998463-10	2019	The finding of this study revealed that, in comparison to sorafenib alone, the treatment of HUH7 with a nanomicelle curcumin IC50 dose, in combination with sorafenib, might down-regulate CCN D1 gene expression.	Curcumin	116-124	cyclin D1	Homo sapiens	187-193
31998463-11	2019	Conclusion: The present research indicates that the treatment of the cell line with only nanomicelle curcumin results in the down-regulation of cyclin D1.	Curcumin	101-109	cyclin D1	Homo sapiens	144-153
31998463-12	2019	To further decrease cyclin D1 expression, the co-delivery of curcumin and sorafenib appears to induce the apoptotic process.	Curcumin	61-69	cyclin D1	Homo sapiens	20-29
32020216-4	2020	In the present study, we evaluated the potential of curcumin to re-express hypermethylated BRCA1 and to suppress hypomethylated SNCG in triple-negative breast cancer (TNBC) cell line HCC-38, the estrogen receptor-negative/progesterone receptor-negative (ER-/PR-) cell line UACC-3199, and the ER+/PR+ cell line T47D.	Curcumin	52-60	synuclein gamma	Homo sapiens	128-132
31362455-11	2019	These results emphasize the strong inhibitory effect of curcumin on ODC activity and subsequent polyamine synthesis.	Curcumin	56-64	ornithine decarboxylase 1	Homo sapiens	68-71
31362455-12	2019	Further molecular dynamic studies to elucidate the mechanistics of ODC inhibition by curcumin are ongoing.	Curcumin	85-93	ornithine decarboxylase 1	Homo sapiens	67-70
32020216-4	2020	In the present study, we evaluated the potential of curcumin to re-express hypermethylated BRCA1 and to suppress hypomethylated SNCG in triple-negative breast cancer (TNBC) cell line HCC-38, the estrogen receptor-negative/progesterone receptor-negative (ER-/PR-) cell line UACC-3199, and the ER+/PR+ cell line T47D.	Curcumin	52-60	epiregulin	Homo sapiens	254-256
31148250-8	2019	The curcumin group had increased bFGF (P < .001) expression on day 4.	Curcumin	4-12	fibroblast growth factor 2	Rattus norvegicus	33-37
31432122-11	2019	In addition, curcumin decreased the cell viability, amylase activity and the phosphorylation of p38 in AR42J cells, but did not affect the intracellular levels of IL-6 and TNF-alpha.	Curcumin	13-21	mitogen activated protein kinase 14	Rattus norvegicus	96-99
32020216-6	2020	We found that curcumin treatment restored BRCA1 gene expression by reducing the DNA promoter methylation level in HCC-38 and UACC-3199 cells and that it suppressed the expression of SNCG by inducing DNA promoter methylation in T47D cells.	Curcumin	14-22	synuclein gamma	Homo sapiens	182-186
31316871-11	2019	Curcumin treatment could inhibit the expression of NOX1, NOX2 and NOX4, decreasing oxidative stress and apoptosis.	Curcumin	0-8	NADPH oxidase 1	Mus musculus	51-55
32020216-8	2020	Curcumin-induced hypomethylation of the BRCA1 promoter appears to be realized through the upregulation of the ten-eleven translocation 1 (TET1) gene, whereas curcumin-induced hypermethylation of SNCG may be realized through the upregulation of the DNA methyltransferase 3 (DNMT3) and the downregulation of TET1.	Curcumin	158-166	synuclein gamma	Homo sapiens	195-199
31316871-11	2019	Curcumin treatment could inhibit the expression of NOX1, NOX2 and NOX4, decreasing oxidative stress and apoptosis.	Curcumin	0-8	cytochrome b-245, beta polypeptide	Mus musculus	57-61
31316871-11	2019	Curcumin treatment could inhibit the expression of NOX1, NOX2 and NOX4, decreasing oxidative stress and apoptosis.	Curcumin	0-8	NADPH oxidase 4	Mus musculus	66-70
32020216-9	2020	Notably, miR-29b was found to be reversely expressed compared to TET1 in curcumin- and 5"-aza-CdR-treated cells, suggesting its involvement in the regulation of TET1.	Curcumin	73-81	microRNA 29b-1	Homo sapiens	9-16
31316871-14	2019	Curcumin treatment could reduce the oxidative stress in seminal vesicle by decreasing the expression of NOX1, NOX2 and NOX4, thereby ameliorating apoptosis and atrophy of seminal vesicle.	Curcumin	0-8	NADPH oxidase 1	Mus musculus	104-108
31523430-3	2019	The objective of this study was to evaluate the anti-cancer potential of curcumin on oral squamous cell carcinoma based on the expression of the nuclear factor kappa B and cyclooxygenase 2 during epithelial dysplasia stage.	Curcumin	73-81	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	172-188
31523430-10	2019	Conclusion: The results of the study suggested that curcumin was effective in suppressing nuclear factor kappa B and cyclooxygenase 2 expression in experimentally induced oral squamous cell carcinoma.	Curcumin	52-60	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	117-133
31948223-3	2020	For this purpose, zeolitic imidazolate framework-8 (ZIF-8) was selected as a MOF model to entrap carbon dot (CD) and curcumin (CCM) during its self-assembly, which produces CD/CCM@ZIF-8.	Curcumin	117-125	lysine acetyltransferase 8	Homo sapiens	77-80
31042325-0	2019	Modulation of miR-34a in curcumin-induced antiproliferation of prostate cancer cells.	Curcumin	25-33	microRNA 34a	Homo sapiens	14-21
31042325-3	2019	To date, however, the role of miR-34a in the anticancer action of curcumin against prostate cancer has been rarely reported.	Curcumin	66-74	microRNA 34a	Homo sapiens	30-37
31042325-4	2019	In the present study, we showed that curcumin altered the expression of cell cycle-related genes (cyclin D1, PCNA, and p21) and inhibited the proliferation of prostate cancer cells.	Curcumin	37-45	cyclin D1	Homo sapiens	98-107
31042325-5	2019	Furthermore, we found that curcumin significantly upregulated the expression of miR-34a, along with the downregulated expression of beta-catenin and c-myc in three prostate cancer cell lines.	Curcumin	27-35	microRNA 34a	Homo sapiens	80-87
31042325-6	2019	Inhibition of miR-34a activated beta-catenin/c-myc axis, altered cell cycle-related genes expression and significantly suppressed the antiproliferation effect of curcumin in prostate cancer cells.	Curcumin	162-170	microRNA 34a	Homo sapiens	14-21
31042325-7	2019	Findings from this study revealed that miR-34a plays an important role in the antiproliferation effect of curcumin in prostate cancer.	Curcumin	106-114	microRNA 34a	Homo sapiens	39-46
31184357-1	2019	We report a one-step emulsification and rapid freeze-drying process to develop a curcumin-ionic liquid (CCM-IL) complex that could be readily dispersed in water with a significantly enhanced solubility of ~8 mg mL-1 and half-life (t1/2) of ~260 min compared with free CCM (solubility ~30 nM and t1/2 ~ 20 min).	Curcumin	81-89	interleukin 1 receptor like 1	Homo sapiens	295-304
30915623-0	2019	Curcumin Can Improve Spinal Cord Injury by Inhibiting TGF-beta-SOX9 Signaling Pathway.	Curcumin	0-8	SRY-box transcription factor 9	Homo sapiens	63-67
30915623-6	2019	Curcumin can play an important role in SCI recovery by inhibiting the expression of NF-kappaB and TGF-beta-SOX9.	Curcumin	0-8	SRY-box transcription factor 9	Homo sapiens	107-111
30869142-6	2019	There was a linear (P &lt; 0.001) effect of dietary curcumin on relative abundance of SOD1, GPX1, CAT, HO-1, and Nrf2 transcripts, and a quadratic (P &lt; 0.001) increase in the activities of GSH-Px and T-AOC in jejunal mucosa.	Curcumin	52-60	superoxide dismutase [Cu-Zn]	Anas platyrhynchos	86-90
30915623-7	2019	Herein, we review the potential mechanism of curcumin-inhibiting SOX9 signaling pathway in SCI treatment.	Curcumin	45-53	SRY-box transcription factor 9	Homo sapiens	65-69
31948223-3	2020	For this purpose, zeolitic imidazolate framework-8 (ZIF-8) was selected as a MOF model to entrap carbon dot (CD) and curcumin (CCM) during its self-assembly, which produces CD/CCM@ZIF-8.	Curcumin	127-130	lysine acetyltransferase 8	Homo sapiens	77-80
30915623-8	2019	The inhibition of NF-kappaB and SOX9 signaling pathway by curcumin has the potentiality of serving as neuronal regenerative mechanism following SCI.	Curcumin	58-66	SRY-box transcription factor 9	Homo sapiens	32-36
31948223-3	2020	For this purpose, zeolitic imidazolate framework-8 (ZIF-8) was selected as a MOF model to entrap carbon dot (CD) and curcumin (CCM) during its self-assembly, which produces CD/CCM@ZIF-8.	Curcumin	176-179	lysine acetyltransferase 8	Homo sapiens	77-80
31602860-0	2019	[Curcumin inhibits proliferation,migration and invasion of gastric cancer cells via Wnt3a/beta-catenin/EMT signaling pathway].	Curcumin	1-9	Wnt family member 3A	Homo sapiens	84-89
31659616-5	2020	We have been able to demonstrate that curcumin significantly increases oxidative stress and accelerates replicative and chronological aging of yeast cells devoid of anti-oxidative protection (with SOD1 and SOD2 gene deletion) and deprived of DNA repair mechanisms (RAD52).	Curcumin	38-46	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	197-201
31602860-7	2019	Moreover,curcumin could inhibit the migration and invasion of MKN45 cells,downregulate the expression of N-cadherin,snail1,Wnt3 a,p-beta-catenin,p-LRP6 and Bcl-2,and upregulate the expression of E-cadherin and Bax,it could increase the activity of caspase-3,caspase-8,caspase-9 and induce apoptosis as well.	Curcumin	9-17	Wnt family member 3A	Homo sapiens	123-129
31602860-7	2019	Moreover,curcumin could inhibit the migration and invasion of MKN45 cells,downregulate the expression of N-cadherin,snail1,Wnt3 a,p-beta-catenin,p-LRP6 and Bcl-2,and upregulate the expression of E-cadherin and Bax,it could increase the activity of caspase-3,caspase-8,caspase-9 and induce apoptosis as well.	Curcumin	9-17	caspase 8	Homo sapiens	258-267
31234318-4	2019	In agreement with prediction, curcumin inhibited NF-kappaB and Aurora-A, and induced G2/M arrest and apoptosis.	Curcumin	30-38	aurora kinase A	Homo sapiens	63-71
31172987-0	2019	A curcumin derivative, WZ35, suppresses hepatocellular cancer cell growth via downregulating YAP-mediated autophagy.	Curcumin	2-10	Yes1 associated transcriptional regulator	Homo sapiens	93-96
31773429-0	2020	In vitro anti-inflammatory effects of curcumin on mast cell-mediated allergic responses via inhibiting FcepsilonRI protein expression and protein kinase C delta translocation.	Curcumin	38-46	Fc epsilon receptor Ia	Homo sapiens	103-114
31773429-0	2020	In vitro anti-inflammatory effects of curcumin on mast cell-mediated allergic responses via inhibiting FcepsilonRI protein expression and protein kinase C delta translocation.	Curcumin	38-46	protein kinase C delta	Homo sapiens	138-160
31773429-6	2020	Curcumin showed the activity against histamine and beta-hexosaminidase releases from both IgE-mediated and A23187-induced cells degranulation.	Curcumin	0-8	O-GlcNAcase	Homo sapiens	51-70
31085592-0	2019	Targeted Delivery of Curcumin Rescues Endoplasmic Reticulum-Retained Mutant NOX2 Protein and Avoids Leukocyte Apoptosis.	Curcumin	21-29	cytochrome b-245, beta polypeptide	Mus musculus	76-80
31773429-10	2020	Curcumin also successfully reduced FcepsilonRI expressions and some pro-inflammatory cytokines, such as interleukin (IL)-4 and IL-13.	Curcumin	0-8	Fc epsilon receptor Ia	Homo sapiens	35-46
31773429-11	2020	Furthermore, curcumin inhibited protein kinase C (PKC)-delta translocation from cytosolic to particulate.	Curcumin	13-21	protein kinase C delta	Homo sapiens	32-60
31085592-6	2019	In vivo studies showed that ER-targeting curcumin-loaded PLGA NPs treatment enhanced neutrophil gp91phox expression, ROS production and peritoneal bacterial clearance ability of the CybbC1024T transgenic Cybb -/- mice.	Curcumin	41-49	cytochrome b-245, beta polypeptide	Mus musculus	182-186
31816386-0	2020	Curcumin ameliorates oxidative stress-induced intestinal barrier injury and mitochondrial damage by promoting Parkin dependent mitophagy through AMPK-TFEB signal pathway.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	145-149
31006841-10	2019	Moreover, treatment with autophagy-specific inhibitors or stable knockdown of LC3B by shRNA could markedly enhance curcumin-induced apoptosis.	Curcumin	115-123	microtubule associated protein 1 light chain 3 beta	Homo sapiens	78-82
31816386-0	2020	Curcumin ameliorates oxidative stress-induced intestinal barrier injury and mitochondrial damage by promoting Parkin dependent mitophagy through AMPK-TFEB signal pathway.	Curcumin	0-8	transcription factor EB	Sus scrofa	150-154
31816386-10	2020	Immunofluorescence and luciferase assay showed that curcumin dramatically enhanced nuclear translocation and transcriptional activity of transcription factor EB (TFEB) in IPEC-J2 cells treated with H2O2, and it was ameliorated by co-treated with compound C, an Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) inhibitor, which means curcumin promotes TFEB transcript via AMPK signal pathway.	Curcumin	52-60	transcription factor EB	Sus scrofa	137-160
31816386-10	2020	Immunofluorescence and luciferase assay showed that curcumin dramatically enhanced nuclear translocation and transcriptional activity of transcription factor EB (TFEB) in IPEC-J2 cells treated with H2O2, and it was ameliorated by co-treated with compound C, an Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) inhibitor, which means curcumin promotes TFEB transcript via AMPK signal pathway.	Curcumin	52-60	transcription factor EB	Sus scrofa	162-166
31816386-10	2020	Immunofluorescence and luciferase assay showed that curcumin dramatically enhanced nuclear translocation and transcriptional activity of transcription factor EB (TFEB) in IPEC-J2 cells treated with H2O2, and it was ameliorated by co-treated with compound C, an Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) inhibitor, which means curcumin promotes TFEB transcript via AMPK signal pathway.	Curcumin	52-60	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	320-324
31816386-10	2020	Immunofluorescence and luciferase assay showed that curcumin dramatically enhanced nuclear translocation and transcriptional activity of transcription factor EB (TFEB) in IPEC-J2 cells treated with H2O2, and it was ameliorated by co-treated with compound C, an Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) inhibitor, which means curcumin promotes TFEB transcript via AMPK signal pathway.	Curcumin	52-60	transcription factor EB	Sus scrofa	367-371
31145652-7	2019	Then, we identified that curcumin upregulated the expression of self-renewal genes, Notch1 and Hes1, and augmentation of CDK4, Cyclin D1, NICD, and Hes1 protein.	Curcumin	25-33	hes family bHLH transcription factor 1	Mus musculus	95-99
31145652-7	2019	Then, we identified that curcumin upregulated the expression of self-renewal genes, Notch1 and Hes1, and augmentation of CDK4, Cyclin D1, NICD, and Hes1 protein.	Curcumin	25-33	hes family bHLH transcription factor 1	Mus musculus	148-152
31816386-10	2020	Immunofluorescence and luciferase assay showed that curcumin dramatically enhanced nuclear translocation and transcriptional activity of transcription factor EB (TFEB) in IPEC-J2 cells treated with H2O2, and it was ameliorated by co-treated with compound C, an Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) inhibitor, which means curcumin promotes TFEB transcript via AMPK signal pathway.	Curcumin	52-60	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	387-391
31816386-10	2020	Immunofluorescence and luciferase assay showed that curcumin dramatically enhanced nuclear translocation and transcriptional activity of transcription factor EB (TFEB) in IPEC-J2 cells treated with H2O2, and it was ameliorated by co-treated with compound C, an Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) inhibitor, which means curcumin promotes TFEB transcript via AMPK signal pathway.	Curcumin	349-357	transcription factor EB	Sus scrofa	137-160
31816386-10	2020	Immunofluorescence and luciferase assay showed that curcumin dramatically enhanced nuclear translocation and transcriptional activity of transcription factor EB (TFEB) in IPEC-J2 cells treated with H2O2, and it was ameliorated by co-treated with compound C, an Adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) inhibitor, which means curcumin promotes TFEB transcript via AMPK signal pathway.	Curcumin	349-357	transcription factor EB	Sus scrofa	162-166
31894298-0	2020	Curcumin rescues breast cells from epithelial-mesenchymal transition and invasion induced by anti-miR-34a.	Curcumin	0-8	microRNA 34a	Homo sapiens	98-105
30878804-0	2019	Supramolecular nanoassembly of lysozyme and alpha-lactalbumin (apo alpha-LA) exhibits selective cytotoxicity and enhanced bioavailability of curcumin to cancer cells.	Curcumin	141-149	lysozyme C, tracheal isozyme	Bos taurus	31-39
31704321-9	2020	CUR-supplementation resulted in a significant improvement in most indices, amelioration of histological alterations and up-regulation of CYP450 and GST expression.	Curcumin	0-3	glutathione S-transferase	Oreochromis niloticus	148-151
30935902-6	2019	The inhibitory effect of curcumin, piperine and vitamin E on cell proliferation involves different markers, and in particular inhibits beta-catenin, cyclinD1 and p53, making them candidates for a possible use in alternative therapies although further studies are needed.	Curcumin	25-33	cyclin D1	Homo sapiens	149-157
31011719-7	2019	The bioaccessibility of curcumin was 50.7% in the emulsion system and 7.8% in the bulk oil when using the TIM-1 model, which simulated the digestion conditions of the entire human GI tract.	Curcumin	24-32	Rho guanine nucleotide exchange factor 5	Homo sapiens	106-111
31590861-10	2020	These results indicate that CHI/CS/Lecithin NPs have more appropriate characteristics for encapsulation of curcumin.	Curcumin	107-115	citrate synthase	Homo sapiens	28-34
31223428-5	2019	Curcumin inhibited the expression of cleaved caspase3, cleaved poly (ADP-ribose) polymerase (PARP), C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the chondroprotective protein Bcl2 in TBHP-treated chondrocytes.	Curcumin	0-8	caspase 3	Rattus norvegicus	45-53
31223428-8	2019	By applying immunohistochemical analysis, we found that curcumin enhanced the expression of SIRT1 and inhibited the expression of CHOP and cleaved caspase3 in ACLT rats.	Curcumin	56-64	caspase 3	Rattus norvegicus	147-155
31421247-13	2019	The phosphorylated-extracellular signal-regulated kinase, phosphorylated-JNK, and phospho-p38 levels were significantly lower in the SCI-hypoglycemia-curcumin group than in the SCI-hypoglycemia group.	Curcumin	150-158	mitogen activated protein kinase 14	Rattus norvegicus	90-93
30988750-9	2019	The artery blood PaCO2, serum Smad4, Smurf2 and IL-4 in the curcumin group were significantly lower on day 1 than those on day 5 (P&lt;0.05).	Curcumin	60-68	interleukin 4	Rattus norvegicus	48-52
30942233-0	2019	Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3beta pathway.	Curcumin	0-8	glycogen synthase kinase 3 alpha	Mus musculus	145-154
31403228-0	2019	Curcumin mitigates the epithelial-to-mesenchymal transition in biliary epithelial cells through upregulating CD109 expression.	Curcumin	0-8	CD109 molecule	Homo sapiens	109-114
30942233-5	2019	Exosomes derived from curcumin-treated (primed) cells (Exo-cur) can better prevent the death of neurons in vitro and in vivo to relieve the symptoms of AD by inhibiting phosphorylation of the Tau protein through activating the AKT/GSK-3beta pathway.	Curcumin	22-30	glycogen synthase kinase 3 alpha	Mus musculus	231-240
31168341-0	2019	Protective effects of curcumin on diabetic nephropathy via attenuation of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression and alleviation of oxidative stress in rats with type 1 diabetes.	Curcumin	22-30	lipocalin 2	Rattus norvegicus	111-153
31168341-0	2019	Protective effects of curcumin on diabetic nephropathy via attenuation of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression and alleviation of oxidative stress in rats with type 1 diabetes.	Curcumin	22-30	lipocalin 2	Rattus norvegicus	155-159
31168341-2	2019	The present study was conducted to examine the protective effect of curcumin on the expression of KIM-1, NGAL genes and oxidative damage in the kidney of T1D rats.	Curcumin	68-76	lipocalin 2	Rattus norvegicus	105-109
31168341-10	2019	Curcumin administration had a significant role in modulation of serum lipid profile, and it was shown to decrease the kidney and urinary expression levels of KIM-1 and NGAL genes and improve oxidative toxic stress in the kidney tissues.	Curcumin	0-8	lipocalin 2	Rattus norvegicus	168-172
31403228-5	2019	Mechanistically, curcumin significantly attenuated the TGF-beta1-induced Smad and Hedgehog signaling, and upregulated CD109 expression in BECs.	Curcumin	17-25	CD109 molecule	Homo sapiens	118-123
31554072-6	2019	In terms of TIM-1 result, curcumin bioaccessibility in OVT fibril-stabilized emulsion increased by 129% when compared with that in bulk oil.	Curcumin	26-34	Rho guanine nucleotide exchange factor 5	Homo sapiens	12-17
31554072-8	2019	Interestingly, both TIM-1 and pH-stat digestion models gave almost consistent measurements of improved percentage in curcumin bioaccessibility.	Curcumin	117-125	Rho guanine nucleotide exchange factor 5	Homo sapiens	20-25
31554072-9	2019	Curcumin bioaccessibility of the emulsion in TIM-1 and pH-stat model was 15.3% and 33.8% respectively, indicating bioaccessibility overestimation in pH-stat model.	Curcumin	0-8	Rho guanine nucleotide exchange factor 5	Homo sapiens	45-50
31762728-12	2019	Curcumin upregulated the expression of PGC-1alpha, NRF1, and Mn-SOD, and downregulated the expression of GRP78, PERK, and IRE1alpha in hepatic tissue.	Curcumin	0-8	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	39-49
30660832-6	2019	Curcumin significantly reduces co-stimulatory molecules and also inhibits MAPK activation and the translocation of NF-kappaB p65.	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	115-128
31762728-12	2019	Curcumin upregulated the expression of PGC-1alpha, NRF1, and Mn-SOD, and downregulated the expression of GRP78, PERK, and IRE1alpha in hepatic tissue.	Curcumin	0-8	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	122-131
31432177-0	2019	Curcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR pathways.	Curcumin	0-8	MYD88 innate immune signal transduction adaptor	Homo sapiens	101-106
31432177-7	2019	Furthermore, curcumin significantly inhibited the expression of Toll-like receptor 4 (TLR4)/MyD88 and EGFR in a dose- and time-dependent manner.	Curcumin	13-21	MYD88 innate immune signal transduction adaptor	Homo sapiens	92-97
31432177-8	2019	Conversely, EGF reversed the inhibitory action of curcumin on TLR4/MyD88.	Curcumin	50-58	MYD88 innate immune signal transduction adaptor	Homo sapiens	67-72
30988630-0	2019	A novel curcumin derivative CL-6 exerts antitumor effect in human gastric cancer cells by inducing apoptosis through Hippo-YAP signaling pathway.	Curcumin	8-16	Yes1 associated transcriptional regulator	Homo sapiens	123-126
31595849-5	2019	Finally, the effect of Curcumin on the transcriptional efficiencies of miR-146a, nNOS, eNOS and iNOS was studied using luciferase assay.	Curcumin	23-31	nitric oxide synthase 1	Homo sapiens	81-85
31595849-10	2019	Moreover, Curcumin enhanced miR-146a expression, while reducing the expression of nNOS, iNOS, cGPM, caspase-3 and PKG as well as the synthesis of NO.	Curcumin	10-18	nitric oxide synthase 1	Homo sapiens	82-86
31595849-13	2019	The protective effect of Curcumin against RIRI may be mediated by its regulation of cell apoptosis through the miR-146a/nNOS/NO/cGMP/PKG signaling pathway.	Curcumin	25-33	nitric oxide synthase 1	Homo sapiens	120-124
30872773-8	2019	JAK2 activity was inhibited using either curcumin, a natural compound with strong JAK2 inhibitor activity, or Tofacitinib, a clinically used selective JAK small molecule inhibitor.	Curcumin	41-49	Janus kinase 2	Homo sapiens	0-3
30936742-0	2019	Nano-curcumin"s suppression of breast cancer cells (MCF7) through the inhibition of cyclinD1 expression.	Curcumin	5-13	cyclin D1	Homo sapiens	84-92
31593984-8	2019	Curcumin significantly suppressed IL-1beta-induced phosphorylated extracellular signal-regulated kinase, Akt, c-Jun NH(2)-terminal kinase, and nuclear factor kappa-light-chain-enhancer of activated B cells, p65 proteins and stimulated beta-catenin translocation into nucleus during adipogenesis.	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	207-210
30936742-15	2019	In addition, curcumin was able to significantly reduce the expression of cyclinD1, whereas CAF did not alter cyclinD1 expression.	Curcumin	13-21	cyclin D1	Homo sapiens	73-81
30936742-16	2019	Conclusion: Nano-curcumin has a relatively high cytotoxic effect on MCF7 breast cancer cells, suppressing the expression of cyclinD1, a critical gene in the development and metastasis of breast cancer.	Curcumin	17-25	cyclin D1	Homo sapiens	124-132
31616564-0	2019	Hyaluronic acid-curcumin conjugate suppresses the fibrotic functions of myofibroblasts from contractive joint by the PTGER2 demethylation.	Curcumin	16-24	prostaglandin E receptor 2	Homo sapiens	117-123
30472378-0	2019	Curcumin modulates the angiogenic potential of human endothelial cells via FAK/P-38 MAPK signaling pathway.	Curcumin	0-8	protein tyrosine kinase 2	Homo sapiens	75-78
30472378-11	2019	Based on data from the current experiment, the protein level of p-FAK/FAK ratio was increased coincided with a decrease in p-P38/P38 ratio treatment with curcumin (p &lt; 0.0001).	Curcumin	154-162	protein tyrosine kinase 2	Homo sapiens	66-69
30472378-11	2019	Based on data from the current experiment, the protein level of p-FAK/FAK ratio was increased coincided with a decrease in p-P38/P38 ratio treatment with curcumin (p &lt; 0.0001).	Curcumin	154-162	protein tyrosine kinase 2	Homo sapiens	70-73
30472378-12	2019	These data demonstrated that curcumin inhibited HUVECs angiogenesis potential by modulation of FAK/P-38 MAPK signaling pathway.	Curcumin	29-37	protein tyrosine kinase 2	Homo sapiens	95-98
29310523-3	2019	Till now only two scaffolds (triazinone and curcumin) derivatives have been reported as BACE-1 and GSK-3beta dual inhibitors.	Curcumin	44-52	glycogen synthase kinase 3 beta	Homo sapiens	99-108
31754658-0	2019	Curcumin Downregulates GSK3 and Cdk5 in Scopolamine-Induced Alzheimer"s Disease Rats Abrogating Abeta40/42 and Tau Hyperphosphorylation.	Curcumin	0-8	cyclin-dependent kinase 5	Rattus norvegicus	32-36
31754658-7	2019	Phospho-GSK3beta (Tyr216), the active form of GSK3beta, and total GSK3beta were significantly decreased in AD rats treated with curcumin.	Curcumin	128-136	glycogen synthase kinase 3 beta	Rattus norvegicus	8-16
31754658-7	2019	Phospho-GSK3beta (Tyr216), the active form of GSK3beta, and total GSK3beta were significantly decreased in AD rats treated with curcumin.	Curcumin	128-136	glycogen synthase kinase 3 beta	Rattus norvegicus	46-54
31754658-7	2019	Phospho-GSK3beta (Tyr216), the active form of GSK3beta, and total GSK3beta were significantly decreased in AD rats treated with curcumin.	Curcumin	128-136	glycogen synthase kinase 3 beta	Rattus norvegicus	46-54
31754658-8	2019	Furthermore, Cdk5 and its activators p35 and p25 were significantly decreased in curcumin-treated AD rats.	Curcumin	81-89	cyclin-dependent kinase 5	Rattus norvegicus	13-17
31754658-8	2019	Furthermore, Cdk5 and its activators p35 and p25 were significantly decreased in curcumin-treated AD rats.	Curcumin	81-89	lipocalin 2	Rattus norvegicus	45-48
31754658-9	2019	The reduced levels of Cdk5, p35, p25, and GSK3beta in curcumin-treated AD rats may result decreased Abeta aggregation and tau hyperphosphorylation, thus ameliorating AD.	Curcumin	54-62	cyclin-dependent kinase 5	Rattus norvegicus	22-26
31754658-9	2019	The reduced levels of Cdk5, p35, p25, and GSK3beta in curcumin-treated AD rats may result decreased Abeta aggregation and tau hyperphosphorylation, thus ameliorating AD.	Curcumin	54-62	lipocalin 2	Rattus norvegicus	33-36
31754658-9	2019	The reduced levels of Cdk5, p35, p25, and GSK3beta in curcumin-treated AD rats may result decreased Abeta aggregation and tau hyperphosphorylation, thus ameliorating AD.	Curcumin	54-62	glycogen synthase kinase 3 beta	Rattus norvegicus	42-50
30993920-12	2019	HFD+curcumin+capsaicin caused decreased BAX, caspase-3, TOS, and ROS levels as compared to HFD, but increased TAS and Bcl-2.	Curcumin	4-12	caspase 3	Rattus norvegicus	45-54
30800669-6	2019	It was found that, after 14 days of the induction by curcumin, NTERA2 cells showed neuronal morphology and expressed neural-specific genes, including NeuroD, TUJ1, and PAX6.	Curcumin	53-61	paired box 6	Homo sapiens	168-172
30800669-7	2019	Importantly, curcumin activated neurogenesis of NTERA2 cells via the activation of autophagy, since autophagy-related genes, such as LC3, LAMP1, and ATG5, were upregulated along with the expression of neural genes.	Curcumin	13-21	lysosomal associated membrane protein 1	Homo sapiens	138-143
30800209-0	2019	Curcumin Suppresses Hepatic Stellate Cell-Induced Hepatocarcinoma Angiogenesis and Invasion through Downregulating CTGF.	Curcumin	0-8	cellular communication network factor 2	Homo sapiens	115-119
30234553-3	2019	In the present study, we quantified the dose-dependent synergistic properties of dietary n-3 polyunsaturated fatty acids (PUFA) and curcumin (Cur) to promote targeted apoptotic deletion of damaged colonic Lgr5 stem cells.	Curcumin	132-140	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	205-209
30800209-5	2019	HIF-1alpha or connective tissue growth factor (CTGF) knockdown could abolish the aforementioned curcumin affection.	Curcumin	96-104	cellular communication network factor 2	Homo sapiens	14-45
30800209-5	2019	HIF-1alpha or connective tissue growth factor (CTGF) knockdown could abolish the aforementioned curcumin affection.	Curcumin	96-104	cellular communication network factor 2	Homo sapiens	47-51
30800209-8	2019	These data indicate that curcumin may induce ROS scavenging by upregulating Nrf2 and GSH, thus inhibiting HIF-1alpha stabilization to suppress CTGF expression to exhibit its protection on HCC.	Curcumin	25-33	cellular communication network factor 2	Homo sapiens	143-147
30800209-10	2019	CTGF is responsible for curcumin-induced protection in HCC.	Curcumin	24-32	cellular communication network factor 2	Homo sapiens	0-4
31034848-0	2019	Curcumin is an APE1 redox inhibitor and exhibits an antiviral activity against KSHV replication and pathogenesis.	Curcumin	0-8	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	15-19
31034848-5	2019	Here we present evidence indicating that curcumin is not a PAINS, but an inhibitor to APE1 redox function that affects many genes and pathways.	Curcumin	41-49	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	86-90
31005039-10	2019	In vitro curcumin inhibited the degradation of IkappaBalpha and reduced the production of COX-2 in LPS-induced inflammatory RAW264.7 cells.	Curcumin	9-17	cytochrome c oxidase II, mitochondrial	Mus musculus	90-95
31074052-4	2019	In the present study, we examined the effect of curcumin on the gene expression of caspase-8, caspase-10, and anti-apoptotic protein c-FLIP, in HAM/TSP patients.	Curcumin	48-56	caspase 8	Homo sapiens	83-92
30951849-7	2019	Curcumin also reduced levels of miR-155, a micro-RNA reported to drive a neurodegenerative microglial phenotype.	Curcumin	0-8	microRNA 155	Mus musculus	32-39
31511210-0	2019	[Curcumin suppresses invasiveness and migration of human glioma cells in vitro by inhibiting HDGF/beta-catenin complex].	Curcumin	1-9	heparin binding growth factor	Homo sapiens	93-97
31234318-5	2019	Curcumin-suppressed NF-kappaB was identified through inhibition of PLCG1, PIK3R1, and MALT1 in the CD4-T-cell-receptor-signaling NF-kappaB cascade pathway.	Curcumin	0-8	MALT1 paracaspase	Homo sapiens	86-91
30974966-0	2019	Curcumin Promotes Connexin 43 Degradation and Temozolomide-Induced Apoptosis in Glioblastoma Cells.	Curcumin	0-8	gap junction protein alpha 1	Homo sapiens	18-29
30974966-5	2019	The aim of this study is to investigate whether curcumin modulates cell apoptosis through the alternation of the connexin 43 (Cx43) protein level in TMZ-resistant GBM.	Curcumin	48-56	gap junction protein alpha 1	Homo sapiens	113-124
31275848-7	2019	Curcumin induces apoptosis in B-Pre-ALL cell lines via activation of caspase-8 and truncation of BID.	Curcumin	0-8	caspase 8	Homo sapiens	69-78
30974966-5	2019	The aim of this study is to investigate whether curcumin modulates cell apoptosis through the alternation of the connexin 43 (Cx43) protein level in TMZ-resistant GBM.	Curcumin	48-56	gap junction protein alpha 1	Homo sapiens	126-130
31275848-8	2019	Curcumin treatment increased the ratio of Bax/Bcl-2 and resulted in a leaky mitochondrial membrane that led to the discharge of cytochrome c from the mitochondria to the cytoplasm, the activation of caspase 3 and the cleavage of PARP.	Curcumin	0-8	collagen type XI alpha 2 chain	Homo sapiens	229-233
31511210-6	2019	In the two glioma cell lines, curcumin significantly suppressed the invasion and migration of the cells (P &amp;lt; 0.05) and lowered the expressions of hepatoma-derived growth factor (HDGF), Ncadherin, vimentin, Snail and Slug, but increased the expression of E-cadherin.	Curcumin	30-38	heparin binding growth factor	Homo sapiens	153-183
31275848-9	2019	Curcumin treatment of B-Pre-ALL cell lines induced a dephosphorylation of the constitutive phosphorylated AKT/PKB and a down-regulation of the expression of cIAP1, and XIAP.	Curcumin	0-8	baculoviral IAP repeat containing 2	Homo sapiens	157-162
30974966-7	2019	Furthermore, at a concentration of 10  mu M, curcumin significantly reduced Cx43 protein expression by about 40%.	Curcumin	45-53	gap junction protein alpha 1	Homo sapiens	76-80
30974966-13	2019	Interestingly, treatment with the proteasome inhibitor MG132 (carbobenzoxy-Leu-Leu-leucinal) significantly negated the curcumin-induced Cx43 degradation, which suggests that curcumin-induced Cx43 degradation occurs through the ubiquitin-proteasome pathway.	Curcumin	119-127	gap junction protein alpha 1	Homo sapiens	136-140
31511210-6	2019	In the two glioma cell lines, curcumin significantly suppressed the invasion and migration of the cells (P &amp;lt; 0.05) and lowered the expressions of hepatoma-derived growth factor (HDGF), Ncadherin, vimentin, Snail and Slug, but increased the expression of E-cadherin.	Curcumin	30-38	heparin binding growth factor	Homo sapiens	185-189
30974966-13	2019	Interestingly, treatment with the proteasome inhibitor MG132 (carbobenzoxy-Leu-Leu-leucinal) significantly negated the curcumin-induced Cx43 degradation, which suggests that curcumin-induced Cx43 degradation occurs through the ubiquitin-proteasome pathway.	Curcumin	119-127	gap junction protein alpha 1	Homo sapiens	191-195
31511210-7	2019	Interference of HDGF in curcumin-treated glioma cells synergistically inhibited the epithelial-mesenchymal transition (EMT) signals, while overexpression of HDGF significantly reversed the inhibitory effect of curcumin on EMT; curcumin treatment could significantly reduce the binding of HDGF to beta-catenin.	Curcumin	24-32	heparin binding growth factor	Homo sapiens	16-20
30974966-13	2019	Interestingly, treatment with the proteasome inhibitor MG132 (carbobenzoxy-Leu-Leu-leucinal) significantly negated the curcumin-induced Cx43 degradation, which suggests that curcumin-induced Cx43 degradation occurs through the ubiquitin-proteasome pathway.	Curcumin	174-182	gap junction protein alpha 1	Homo sapiens	136-140
30974966-13	2019	Interestingly, treatment with the proteasome inhibitor MG132 (carbobenzoxy-Leu-Leu-leucinal) significantly negated the curcumin-induced Cx43 degradation, which suggests that curcumin-induced Cx43 degradation occurs through the ubiquitin-proteasome pathway.	Curcumin	174-182	gap junction protein alpha 1	Homo sapiens	191-195
30551377-0	2019	Curcumin pretreatment protects against hypoxia/reoxgenation injury via improvement of mitochondrial function, destabilization of HIF-1alpha and activation of Epac1-Akt pathway in rat bone marrow mesenchymal stem cells.	Curcumin	0-8	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	158-163
30551377-7	2019	In addition, curcumin pretreatment notably induced HIF-1alpha destabilization, Epac1 and Akt activation, and Erk1/2 and p38 deactivation.	Curcumin	13-21	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	79-84
29808718-7	2019	Furthermore, we identified a 1,5-diheteroarylpenta-1,4-dien-3-one (Compound 23, or C23) as a novel potent PP2Cdelta inhibitor with a striking cytotoxicity on MCF-7 cells through cell-based screening assay for growth inhibition and activity of a group of curcumin mimics.	Curcumin	254-262	nucleolin	Homo sapiens	83-86
31360692-14	2019	Baicalein exhibited the synergistic effect on inhibition of COX-2 induced by DSS with curcumin, an ingredient of turmeric.	Curcumin	86-94	cytochrome c oxidase II, mitochondrial	Mus musculus	60-65
31511210-7	2019	Interference of HDGF in curcumin-treated glioma cells synergistically inhibited the epithelial-mesenchymal transition (EMT) signals, while overexpression of HDGF significantly reversed the inhibitory effect of curcumin on EMT; curcumin treatment could significantly reduce the binding of HDGF to beta-catenin.	Curcumin	210-218	heparin binding growth factor	Homo sapiens	16-20
31511210-7	2019	Interference of HDGF in curcumin-treated glioma cells synergistically inhibited the epithelial-mesenchymal transition (EMT) signals, while overexpression of HDGF significantly reversed the inhibitory effect of curcumin on EMT; curcumin treatment could significantly reduce the binding of HDGF to beta-catenin.	Curcumin	210-218	heparin binding growth factor	Homo sapiens	157-161
31511210-7	2019	Interference of HDGF in curcumin-treated glioma cells synergistically inhibited the epithelial-mesenchymal transition (EMT) signals, while overexpression of HDGF significantly reversed the inhibitory effect of curcumin on EMT; curcumin treatment could significantly reduce the binding of HDGF to beta-catenin.	Curcumin	210-218	heparin binding growth factor	Homo sapiens	157-161
31511210-7	2019	Interference of HDGF in curcumin-treated glioma cells synergistically inhibited the epithelial-mesenchymal transition (EMT) signals, while overexpression of HDGF significantly reversed the inhibitory effect of curcumin on EMT; curcumin treatment could significantly reduce the binding of HDGF to beta-catenin.	Curcumin	210-218	heparin binding growth factor	Homo sapiens	16-20
31033209-0	2019	Curcumin induces apoptosis in JAK2-mutated cells by the inhibition of JAK2/STAT and mTORC1 pathways.	Curcumin	0-8	Janus kinase 2	Homo sapiens	30-34
31511210-7	2019	Interference of HDGF in curcumin-treated glioma cells synergistically inhibited the epithelial-mesenchymal transition (EMT) signals, while overexpression of HDGF significantly reversed the inhibitory effect of curcumin on EMT; curcumin treatment could significantly reduce the binding of HDGF to beta-catenin.	Curcumin	210-218	heparin binding growth factor	Homo sapiens	157-161
31033209-0	2019	Curcumin induces apoptosis in JAK2-mutated cells by the inhibition of JAK2/STAT and mTORC1 pathways.	Curcumin	0-8	Janus kinase 2	Homo sapiens	70-74
31511210-7	2019	Interference of HDGF in curcumin-treated glioma cells synergistically inhibited the epithelial-mesenchymal transition (EMT) signals, while overexpression of HDGF significantly reversed the inhibitory effect of curcumin on EMT; curcumin treatment could significantly reduce the binding of HDGF to beta-catenin.	Curcumin	210-218	heparin binding growth factor	Homo sapiens	157-161
31033209-0	2019	Curcumin induces apoptosis in JAK2-mutated cells by the inhibition of JAK2/STAT and mTORC1 pathways.	Curcumin	0-8	CREB regulated transcription coactivator 1	Mus musculus	84-90
31033209-5	2019	Previous studies showed that curcumin, the active principle of the Curcuma longa, can suppress JAK2/STAT pathways in different type of cancer and injuries.	Curcumin	29-37	Janus kinase 2	Homo sapiens	95-99
30551377-7	2019	In addition, curcumin pretreatment notably induced HIF-1alpha destabilization, Epac1 and Akt activation, and Erk1/2 and p38 deactivation.	Curcumin	13-21	mitogen activated protein kinase 3	Rattus norvegicus	109-115
30551377-7	2019	In addition, curcumin pretreatment notably induced HIF-1alpha destabilization, Epac1 and Akt activation, and Erk1/2 and p38 deactivation.	Curcumin	13-21	mitogen activated protein kinase 14	Rattus norvegicus	120-123
31033209-6	2019	In this study, we investigated the anti-proliferative and pro-apoptotic effects of curcumin in JAK2 V617F-mutated cells.	Curcumin	83-91	Janus kinase 2	Homo sapiens	95-99
31511210-8	2019	CONCLUSIONS: Curcumin suppresses EMT signal by reducing HDGF/beta-catenin complex and thereby lowers the migration and invasion abilities of human glioma cells in vitro.	Curcumin	13-21	heparin binding growth factor	Homo sapiens	56-60
30551377-8	2019	However, Epac1 inhibitor ESI-09 obviously restrained the increase of p-Akt induced by curcumin, but not p-Erk1/2 or p-p38, and abrogated the protective effect of curcumin on BMSCs" survival and arrested cell cycle in G0/G1 phase.	Curcumin	86-94	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	9-14
30551377-8	2019	However, Epac1 inhibitor ESI-09 obviously restrained the increase of p-Akt induced by curcumin, but not p-Erk1/2 or p-p38, and abrogated the protective effect of curcumin on BMSCs" survival and arrested cell cycle in G0/G1 phase.	Curcumin	162-170	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	9-14
31033209-11	2019	Furthermore, we showed that curcumin inhibits JAK2/STAT and mTORC1 pathways in JAK2 V617F-mutated cells.	Curcumin	28-36	Janus kinase 2	Homo sapiens	46-50
31455356-7	2019	RESULTS: Curcumin treatment markedly inhibited the degradation of IkappaBalpha, the activation of NF-kappaB signaling pathway, and the expression levels of the NF-kappaB downstream inflammatory genes such as IL-1beta, IL-6, TNF-alpha, COX-2, and PGE2 in the MSU-stimulated THP-1-derived macrophages.	Curcumin	9-17	cytochrome c oxidase II, mitochondrial	Mus musculus	235-240
31033209-11	2019	Furthermore, we showed that curcumin inhibits JAK2/STAT and mTORC1 pathways in JAK2 V617F-mutated cells.	Curcumin	28-36	CREB regulated transcription coactivator 1	Mus musculus	60-66
31033209-11	2019	Furthermore, we showed that curcumin inhibits JAK2/STAT and mTORC1 pathways in JAK2 V617F-mutated cells.	Curcumin	28-36	Janus kinase 2	Homo sapiens	79-83
30551377-9	2019	Taken together, these results demonstrated that curcumin pretreatment conferred BMSCs the ability to survive from H/R injury, which might attribute to its protection on mitochondrial function, destabilization of HIF-1alpha and activation of Epac1-Akt signaling pathway.	Curcumin	48-56	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	241-246
30835338-0	2019	Thymoquinone and curcumin modify iNOS, caspase-3, and thioredoxin immunohistochemical expression in acetaminophen (APAP) hepatotoxicity.	Curcumin	17-25	caspase 3	Rattus norvegicus	39-48
31454362-0	2019	Inhibition and assessment of the biophysical gating properties of GluA2 and GluA2/A3 AMPA receptors using curcumin derivatives.	Curcumin	106-114	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	66-71
30762443-10	2019	The expression of CD31 was reduced while NG2 was increased significantly by the combination of APS and curcumin.	Curcumin	103-111	platelet/endothelial cell adhesion molecule 1	Mus musculus	18-22
31287789-11	2019	Furthermore, IFN-alpha/beta levels induced by TLR4 and IRF3 were decreased in these cells following curcumin treatment.	Curcumin	100-108	interferon regulatory factor 3	Homo sapiens	55-59
31287789-12	2019	CONCLUSIONS: Consequently, these results demonstrated that the activation of LPS stimulated TLR4/TRIF/IRF3 signaling pathway was mediated by curcumin in breast cancer cells, in vitro.	Curcumin	141-149	interferon regulatory factor 3	Homo sapiens	102-106
30246249-6	2019	Mechanistic studies showed that increased ROS levels in cells incubated with 20 muM curcumin induced opening of mitochondrial permeability transition pores and subsequent release of cytochrome c, activation of caspases 9 and 3/7, and apoptotic cell death.	Curcumin	84-92	caspase 9	Mus musculus	210-226
31270880-2	2019	Natural curcumin limits the lytic activity of MMPs but has low cellular uptake.	Curcumin	8-16	matrix metallopeptidase 2	Homo sapiens	46-50
31270880-8	2019	The curcumin compounds modulated pro-MMP-2 levels and increased TIMP-1 production.	Curcumin	4-12	matrix metallopeptidase 2	Homo sapiens	37-42
31270880-11	2019	In conclusion, synthetic curcumins influenced the balance between pro-MMP-2 and TIMP-1 in human periodontal stem cells in vitro, and this could open perspectives for their application as adjuvants in periodontal therapy.	Curcumin	25-34	matrix metallopeptidase 2	Homo sapiens	70-75
31287789-13	2019	However, more studies are necessary to examine the curcumin"s anti-inflammatory activities on TLR4/MyD88/NF-kappaB as well as other signaling pathways downstream of TLRs in breast cancer.	Curcumin	51-59	MYD88 innate immune signal transduction adaptor	Homo sapiens	99-104
31136203-8	2019	Chronic daily oral curcumin dosing led to tumor accumulation of curcumin and inhibition of tumor growth in tumor models with high beta-glucuronidase activity.	Curcumin	19-27	glucuronidase beta	Homo sapiens	130-148
31316871-14	2019	Curcumin treatment could reduce the oxidative stress in seminal vesicle by decreasing the expression of NOX1, NOX2 and NOX4, thereby ameliorating apoptosis and atrophy of seminal vesicle.	Curcumin	0-8	cytochrome b-245, beta polypeptide	Mus musculus	110-114
31316871-14	2019	Curcumin treatment could reduce the oxidative stress in seminal vesicle by decreasing the expression of NOX1, NOX2 and NOX4, thereby ameliorating apoptosis and atrophy of seminal vesicle.	Curcumin	0-8	NADPH oxidase 4	Mus musculus	119-123
30585634-8	2019	In the core signaling pathways of GBM, nano micelles curcumin either significantly influences the NF-kappaB pathway by decreasing p-65 expression or significantly inhibits the Wnt/beta-catenin pathway by declining cyclin D1 expression.	Curcumin	53-61	RELA proto-oncogene, NF-kB subunit	Homo sapiens	130-134
30585634-8	2019	In the core signaling pathways of GBM, nano micelles curcumin either significantly influences the NF-kappaB pathway by decreasing p-65 expression or significantly inhibits the Wnt/beta-catenin pathway by declining cyclin D1 expression.	Curcumin	53-61	cyclin D1	Homo sapiens	214-223
31231548-7	2019	We found that curcumin induced the generation of reactive oxygen species (ROS) which activated caspase 8 and destabilized the mitochondrial membrane potential leading to the release of cytochrome c from mitochondria.	Curcumin	14-22	caspase 8	Bos taurus	95-104
31231548-7	2019	We found that curcumin induced the generation of reactive oxygen species (ROS) which activated caspase 8 and destabilized the mitochondrial membrane potential leading to the release of cytochrome c from mitochondria.	Curcumin	14-22	LOC104968582	Bos taurus	185-197
31231548-10	2019	Curcumin treatment suppressed the mTOR and increased the expression of autophagy-related proteins.	Curcumin	0-8	mechanistic target of rapamycin kinase	Bos taurus	34-38
31244295-6	2019	Quantitative real-time polymerasechain reaction was performed to analyze the effect of curcumin on death receptor-5 (DR-5) gene expression.	Curcumin	87-95	tumor necrosis factor receptor superfamily, member 10b	Mus musculus	99-115
31244295-6	2019	Quantitative real-time polymerasechain reaction was performed to analyze the effect of curcumin on death receptor-5 (DR-5) gene expression.	Curcumin	87-95	tumor necrosis factor receptor superfamily, member 10b	Mus musculus	117-121
30859861-5	2019	Curcumin attenuated PA-induced reduction in cell viability and activation of apoptosis, Caspase 3 activity, BAX, CHOP, and GRP78 expression.	Curcumin	0-8	caspase 3	Rattus norvegicus	88-97
31934029-0	2019	Curcumin attenuates lupus nephritis in MRL/lpr mice by suppressing macrophage-secreted B cell activating factor (BAFF).	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	87-111
31934029-0	2019	Curcumin attenuates lupus nephritis in MRL/lpr mice by suppressing macrophage-secreted B cell activating factor (BAFF).	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	113-117
31934029-8	2019	Levels of BAFF in serum, spleens and kidneys were also reduced in curcumin-treated MRL/lpr mice.	Curcumin	66-74	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	10-14
31934029-9	2019	In vitro experiments showed that curcumin reduced the activation of macrophage and leaded to the decrease of BAFF from them upon toll like receptor (TLR) 4 stimulation.	Curcumin	33-41	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	109-113
31934029-10	2019	Curcumin attenuates lupus nephritis in MRL/lpr mice by inhibiting macrophages activation and their secreting BAFF, which may be a potential therapeutic candidate for the treatment of SLE.	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	109-113
31190888-0	2019	Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-beta/Smad2/3 signaling pathway.	Curcumin	0-8	SMAD family member 2	Homo sapiens	95-100
30955355-0	2019	Synergistic Antiproliferative Effects of Co-nanoencapsulated Curcumin and Chrysin on MDA-MB-231 Breast Cancer Cells Through Upregulating miR-132 and miR-502c.	Curcumin	61-69	microRNA 132	Homo sapiens	137-144
30955355-1	2019	In this study, we explored whether co-nanoencapsulated Curcumin (Cur) and Chrysin (Chr), natural herbal compounds with antitumor activities, regulate miR-132 and miR-502c and their downstream targets, leading to the synergistic growth inhibition in MDA-MB-231 breast cancer cells.	Curcumin	55-63	microRNA 132	Homo sapiens	150-157
30466988-0	2018	Curcumin downregulates expression of opioid-related nociceptin receptor gene (OPRL1) in isolated neuroglia cells.	Curcumin	0-8	opioid related nociceptin receptor 1	Homo sapiens	78-83
30534177-1	2018	Our recent report showed that curcumin, polyphenolic compound isolated from the herb Curcuma longa, upregulated the gene expression of human GD3 synthase (hST8Sia I) responsible for ganglioside GD3 synthesis with autophagy induction in human lung adenocarcinoma A549 cells.	Curcumin	30-38	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	155-164
30137697-0	2018	Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice.	Curcumin	10-18	Janus kinase 1	Mus musculus	152-156
30137697-0	2018	Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice.	Curcumin	10-18	signal transducer and activator of transcription 6	Mus musculus	157-162
30137697-0	2018	Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice.	Curcumin	10-18	notch 2	Mus musculus	191-197
30386242-0	2018	Curcumin"s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-kappaB Pathway.	Curcumin	0-8	mitogen-activated protein kinase kinase kinase 7	Mus musculus	140-144
29499209-6	2018	As a result from inhibiting acetyl CoA accumulation, curcumin protected pyruvate dehydrogenase (PDH) activity and inhibited pyruvate carboxylase (PC), limiting the shift of mitochondrial pyruvate from oxidation to gluconeogenesis via the carboxylation.	Curcumin	53-61	pyruvate carboxylase	Mus musculus	124-144
30243647-13	2018	SIGNIFICANCE: According to these results, it may be suggested that curcumin exerts anticonvulsive effects by increasing the serotonin levels in the brain that influence receptors, including 5-HT1A, 5-HT2C, and 5-HT4 and likely through the reduction of 5-HT7 gene expression.	Curcumin	67-75	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	198-204
30243647-13	2018	SIGNIFICANCE: According to these results, it may be suggested that curcumin exerts anticonvulsive effects by increasing the serotonin levels in the brain that influence receptors, including 5-HT1A, 5-HT2C, and 5-HT4 and likely through the reduction of 5-HT7 gene expression.	Curcumin	67-75	hypothermia due to alcohol sensitivity 4	Mus musculus	212-215
30281585-0	2018	Curcumin Induces Autophagy via Inhibition of Yes-Associated Protein (YAP) in Human Colon Cancer Cells.	Curcumin	0-8	Yes1 associated transcriptional regulator	Homo sapiens	45-67
30281585-0	2018	Curcumin Induces Autophagy via Inhibition of Yes-Associated Protein (YAP) in Human Colon Cancer Cells.	Curcumin	0-8	Yes1 associated transcriptional regulator	Homo sapiens	69-72
30281585-6	2018	In addition, Western blot results indicated that curcumin suppressed YAP expression in colon cancer cells.	Curcumin	49-57	Yes1 associated transcriptional regulator	Homo sapiens	69-72
30281585-9	2018	Western blot results showed that curcumin reversed the effect of YAP in colon cancer cells.	Curcumin	33-41	Yes1 associated transcriptional regulator	Homo sapiens	65-68
31131678-3	2019	Preclinical data suggest curcumin may have a beneficial effect in PSC.	Curcumin	25-33	PSC	Homo sapiens	66-69
31027362-8	2019	The phytochemicals like sulforaphane and curcumin that can concurrently target SOX9, AR and Wnt/beta-catenin signaling pathways in PCa may thus be beneficial in the chemoprevention of PCa.	Curcumin	41-49	SRY-box transcription factor 9	Homo sapiens	79-83
31073274-0	2019	Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARgamma-Dependent NF-kappaB Signaling Pathway In Vivo and In Vitro.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	87-96
31073274-2	2019	Curcumin possessed a potent anti-inflammatory property involved in the PPARgamma-dependent NF-kappaB signaling pathway.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	71-80
31073274-10	2019	Our data also showed that these effects of curcumin were significantly abrogated by shRNA-PPARgamma.	Curcumin	43-51	peroxisome proliferator activated receptor gamma	Mus musculus	90-99
31073274-11	2019	Taken together, our results indicate that curcumin attenuated OVA-induced airway inflammation and mucus hypersecretion in mice and suppressed OVA- and IL-4-induced upregulation of MCP-1 and MUC5AC both in vivo and in vitro, most likely through a PPARgamma-dependent NF-kappaB signaling pathway.	Curcumin	42-50	peroxisome proliferator activated receptor gamma	Mus musculus	246-255
30889901-0	2019	Curcumin Analogue C1 Promotes Hex and Gal Recruitment to the Plasma Membrane via mTORC1-Independent TFEB Activation.	Curcumin	0-8	O-GlcNAcase	Homo sapiens	30-33
30889901-0	2019	Curcumin Analogue C1 Promotes Hex and Gal Recruitment to the Plasma Membrane via mTORC1-Independent TFEB Activation.	Curcumin	0-8	CREB regulated transcription coactivator 1	Mus musculus	81-87
30889901-0	2019	Curcumin Analogue C1 Promotes Hex and Gal Recruitment to the Plasma Membrane via mTORC1-Independent TFEB Activation.	Curcumin	0-8	transcription factor EB	Homo sapiens	100-104
30889901-1	2019	The monocarbonyl analogue of curcumin (1E,4E)-1,5-Bis(2-methoxyphenyl)penta-1,4-dien-3-one (C1) has been used as a specific activator of the master gene transcription factor EB (TFEB) to correlate the activation of this nuclear factor with the increased activity of lysosomal glycohydrolases and their recruitment to the cell surface.	Curcumin	29-37	transcription factor EB	Homo sapiens	178-182
30936718-0	2019	Curcumin inhibits the proliferation and invasion of MG-63 cells through inactivation of the p-JAK2/p-STAT3 pathway.	Curcumin	0-8	Janus kinase 2	Homo sapiens	94-98
30936718-1	2019	Purpose: The aims of this study were to determine the effect of curcumin on osteosarcoma (OS) cells due to inactivation of the p-JAK2/p-STAT3 pathway and evaluate the prognostic value of this pathway in OS.	Curcumin	64-72	Janus kinase 2	Homo sapiens	129-133
30844765-6	2019	Mechanistically, Curcumin reduced CXCR4 expression in PGCs in vitro and in vivo, and thus likely inhibited metastasis of PGC through suppression of stromal cell -derived factor-1/CXCR4 signaling.	Curcumin	17-25	C-X-C motif chemokine ligand 12	Homo sapiens	148-178
30860465-0	2019	One novel curcumin derivative ZYX01 induces autophagy of human non-small lung cancer cells A549 through AMPK/ULK1/Beclin-1 signaling pathway.	Curcumin	10-18	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	104-108
30860465-0	2019	One novel curcumin derivative ZYX01 induces autophagy of human non-small lung cancer cells A549 through AMPK/ULK1/Beclin-1 signaling pathway.	Curcumin	10-18	unc-51 like autophagy activating kinase 1	Homo sapiens	109-113
30806992-8	2019	Leptin in the curcumin treatment group was markedly higher than all of the studied groups, except the danazol group, while there were no significant differences between other groups (P < 0.05).	Curcumin	14-22	leptin	Rattus norvegicus	0-6
30674964-4	2019	We have also found that all-trans retinoic acid (ATRA) treatment increased AGAP2 protein levels in both cell lines whilst curcumin treatment reduced ATRA-mediated AGAP2 increase.	Curcumin	122-130	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	Homo sapiens	163-168
30774454-3	2019	Methods: The current study compared the efficacy of a novel host-modulation compound, a chemically modified curcumin (CMC 2.24), to that of its parent compound (natural curcumin), in both lipopolysaccharide (LPS) (a bacterial endotoxin)-induced cell culture and in vivo models of periodontitis.	Curcumin	108-116	C-x(9)-C motif containing 2	Rattus norvegicus	118-123
30774454-4	2019	Results: In cell culture, both CMC 2.24 and curcumin appeared similarly effective in suppressing LPS-induced cytokine (IL-1beta and TNF-alpha) secretion by mononuclear inflammatory cells; however, CMC 2.24 significantly reduced MMP-9 secretion by 78% (P&lt;0.05) whereas curcumin was ineffective.	Curcumin	271-279	C-x(9)-C motif containing 2	Rattus norvegicus	31-36
31679307-8	2019	Curcumin efficiently inhibited HCC cell proliferation by blocking the Wnt/beta-catenin pathway and inhabited migration and invasion by blocking the TGF-p/EMT signal pathway.	Curcumin	0-8	transforming growth factor, beta 1	Mus musculus	148-151
30393127-5	2019	While curcumin inhibited TGFbeta-receptor-mediated Smad2/3 phosphorylation in all BCa cells studied (human MDA-SA, MDA-1833, MDA-2287 and murine 4T1 cells), curcumin-glucuronide did not.	Curcumin	6-14	transforming growth factor alpha	Homo sapiens	25-32
30393127-5	2019	While curcumin inhibited TGFbeta-receptor-mediated Smad2/3 phosphorylation in all BCa cells studied (human MDA-SA, MDA-1833, MDA-2287 and murine 4T1 cells), curcumin-glucuronide did not.	Curcumin	6-14	SMAD family member 2	Homo sapiens	51-58
31287789-0	2019	Inhibition of TLR4/TRIF/IRF3 Signaling Pathway by Curcumin in Breast Cancer Cells.	Curcumin	50-58	interferon regulatory factor 3	Homo sapiens	24-28
31287789-9	2019	RESULTS: Curcumin treatment suppressed breast cancer cells viabilities and the activation of TLR4-mediated TRIF signaling pathway by the downregulation of TLR4 and IRF3 expression levels and the inhibition of type I IFN (IFN-alpha/beta) levels induced by LPS.	Curcumin	9-17	interferon regulatory factor 3	Homo sapiens	164-168
30599909-0	2019	Curcumin relieved cisplatin-induced kidney inflammation through inhibiting Mincle-maintained M1 macrophage phenotype.	Curcumin	0-8	C-type lectin domain family 4, member e	Mus musculus	75-81
30599909-5	2019	Here, we investigated the effects of Curcumin on Mincle expression and macrophage polarization in vitro using lipopolysaccharide (LPS) induced macrophage inflammatory cell model and in vivo using a cisplatin induced murine AKI (cis-AKI) model.	Curcumin	37-45	C-type lectin domain family 4, member e	Mus musculus	49-55
30599909-9	2019	The data also demonstrated that Curcumin remarkably down-regulated mRNA expression and protein level of Mincle in cis-AKI kidney and also reduced expression of iNOS (M1 macrophage marker) as well as inhibited the activation of Syk and NF-kB.	Curcumin	32-40	C-type lectin domain family 4, member e	Mus musculus	104-110
30599909-10	2019	Interestingly, although Mincle deletion in RAW264.7 cell largely decreased the LPS-induced protein level of iNOS, Curcumin cannot further reduce expression of iNOS without Mincle, indicating that Curcumin inhibits M1 macrophage with a Mincle-dependent pattern.	Curcumin	196-204	C-type lectin domain family 4, member e	Mus musculus	24-30
30599909-12	2019	CONCLUSION: Our findings prove that Curcumin protects kidney from cisplatin induced AKI through inhibiting Mincle maintained M1 macrophage phenotype, that may provide a specific renoprotection mechanism for Curcumin to develop it as a new therapeutic candidate for AKI.	Curcumin	36-44	C-type lectin domain family 4, member e	Mus musculus	107-113
30333956-5	2018	Treatment of HNSCC cell lines with curcumin, a natural compound isolated from rhizomes of the plant Curcuma longa, or transfection of small interfering RNA of Skp2, causes down-regulation of Skp2 with concomitant accumulation of p21 and p27 in HPV+, HPV- cells.	Curcumin	35-43	S-phase kinase associated protein 2	Homo sapiens	191-195
30333956-10	2018	Altogether, these data suggest an important function for curcumin, acting as a suppressor of oncoprotein Skp2 in squamous cell carcinoma cells in both HPV+ and HPV- cells; raise the possibility that this agent may have a future therapeutic role in squamous cell carcinoma.	Curcumin	57-65	S-phase kinase associated protein 2	Homo sapiens	105-109
30599909-12	2019	CONCLUSION: Our findings prove that Curcumin protects kidney from cisplatin induced AKI through inhibiting Mincle maintained M1 macrophage phenotype, that may provide a specific renoprotection mechanism for Curcumin to develop it as a new therapeutic candidate for AKI.	Curcumin	207-215	C-type lectin domain family 4, member e	Mus musculus	107-113
31190888-12	2019	In addition, curcumin inhibited EMT via regulation of TGF-beta/Smad2/3 signaling pathway.	Curcumin	13-21	SMAD family member 2	Homo sapiens	63-70
31091659-10	2019	Modeling of mTOR protein revealed structural changes upon treatments, and curcumin plus GR decreased binding of Raptor and GbetaL to mTOR, as well as of Rag A and Rag B to Raptor.	Curcumin	74-82	regulatory associated protein of MTOR complex 1	Homo sapiens	112-118
30053224-9	2019	The expression levels of peroxisome proliferators-activated receptor alpha (PPARalpha) and carnitine palmitoyl transferase-I (CPT-I) were significantly increased in the 1,000 and 2,000 mg/kg curcumin groups (P &lt; 0.05).	Curcumin	191-199	carnitine palmitoyltransferase 1A	Gallus gallus	91-124
30053224-9	2019	The expression levels of peroxisome proliferators-activated receptor alpha (PPARalpha) and carnitine palmitoyl transferase-I (CPT-I) were significantly increased in the 1,000 and 2,000 mg/kg curcumin groups (P &lt; 0.05).	Curcumin	191-199	carnitine palmitoyltransferase 1A	Gallus gallus	126-131
30053224-10	2019	These results indicated that curcumin plays an important role in reduction abdominal fat deposition by decreasing the hepatic and plasma lipid profile and affecting the expression levels of genes related to lipogenesis and lipolysis including ACC, FAS, SREBP-1c, ACLY, PPARalpha, and CPT-I.	Curcumin	29-37	carnitine palmitoyltransferase 1A	Gallus gallus	284-289
30119257-10	2018	In vitro, we discovered that curcumin prevents the polarization of macrophages toward M1 and reduces monocyte chemokines secretion, which is involved with ERK1/2 and p38 pathways.	Curcumin	29-37	mitogen-activated protein kinase 3	Mus musculus	155-161
30119257-10	2018	In vitro, we discovered that curcumin prevents the polarization of macrophages toward M1 and reduces monocyte chemokines secretion, which is involved with ERK1/2 and p38 pathways.	Curcumin	29-37	mitogen-activated protein kinase 14	Mus musculus	166-169
31091659-10	2019	Modeling of mTOR protein revealed structural changes upon treatments, and curcumin plus GR decreased binding of Raptor and GbetaL to mTOR, as well as of Rag A and Rag B to Raptor.	Curcumin	74-82	regulatory associated protein of MTOR complex 1	Homo sapiens	172-178
29183161-7	2018	Furthermore, the nano-formulated curcumin effectively indicated a reduction in iNOS-2 and an increase in Arg-1 levels than free curcumin.	Curcumin	33-41	arginase 1	Homo sapiens	105-110
30136034-5	2018	Moreover, the treatment of curcumin for 24 h significantly suppressed cell migration, together with the downregulation of matrix metalloproteinase-2 (MMP-2) and upregulation of tissue inhibitor of metalloproteinases-1 (TIMP-1).	Curcumin	27-35	matrix metallopeptidase 2	Homo sapiens	122-148
30988750-11	2019	The PaCO2, serum Smad4, Smurf2 and IL-4 in the curcumin group were lower than those in the paraquat group (P&lt;0.05).	Curcumin	47-55	interleukin 4	Rattus norvegicus	35-39
30136034-5	2018	Moreover, the treatment of curcumin for 24 h significantly suppressed cell migration, together with the downregulation of matrix metalloproteinase-2 (MMP-2) and upregulation of tissue inhibitor of metalloproteinases-1 (TIMP-1).	Curcumin	27-35	matrix metallopeptidase 2	Homo sapiens	150-155
30066930-5	2018	Therefore, the aim of the current study was to evaluate cell death induced by curcumin and paclitaxel alone and in combination in human breast cancer cell lines: MCF7, an epithelial and luminal-like adenocarcinoma cell line triple positive for estrogen and progesterone receptor, and MDA-MB-234, a metastatic human breast cancer cell line triple negative for such receptors, as well as MCF-10F as a normal breast cell line.	Curcumin	78-86	progesterone receptor	Homo sapiens	257-278
30251185-7	2018	IL-33 in affected fibroblasts was induced by IL-1beta, TNFalpha, or TNFalpha/TGF-beta, while the effect of IL-1beta or TNFalpha/TGF-beta was blocked by curcumin.	Curcumin	152-160	interleukin 33	Homo sapiens	0-5
30466625-5	2018	Curcumin treatment had significantly decreased the phosphorylation of JNK, ERK1/2, and p38 and COX-2 expression thereby nuclear factor kappaB (NF-kappaB) activation and expression in lung tissues.	Curcumin	0-8	mitogen-activated protein kinase 3	Mus musculus	75-81
30466625-5	2018	Curcumin treatment had significantly decreased the phosphorylation of JNK, ERK1/2, and p38 and COX-2 expression thereby nuclear factor kappaB (NF-kappaB) activation and expression in lung tissues.	Curcumin	0-8	mitogen-activated protein kinase 14	Mus musculus	87-90
30466625-5	2018	Curcumin treatment had significantly decreased the phosphorylation of JNK, ERK1/2, and p38 and COX-2 expression thereby nuclear factor kappaB (NF-kappaB) activation and expression in lung tissues.	Curcumin	0-8	cytochrome c oxidase II, mitochondrial	Mus musculus	95-100
30036770-0	2018	Activation of PPARgamma by Curcumin protects mice from ischemia/reperfusion injury induced by orthotopic liver transplantation via modulating polarization of Kupffer cells.	Curcumin	27-35	peroxisome proliferator activated receptor gamma	Mus musculus	14-23
30036770-5	2018	The Western blotting showed that Curcumin inhibited the function of KCs via down-regulating the nuclear factor kappab (NF-kappab) signaling pathway by activating peroxisome proliferator-activated receptor gamma (PPARgamma) and flow cytometry revealed that Curcumin suppressed pro-inflammatory phenotype (M1) of KCs while promoting its anti-inflammatory phenotype (M2) polarization.	Curcumin	33-41	peroxisome proliferator activated receptor gamma	Mus musculus	162-210
30036770-5	2018	The Western blotting showed that Curcumin inhibited the function of KCs via down-regulating the nuclear factor kappab (NF-kappab) signaling pathway by activating peroxisome proliferator-activated receptor gamma (PPARgamma) and flow cytometry revealed that Curcumin suppressed pro-inflammatory phenotype (M1) of KCs while promoting its anti-inflammatory phenotype (M2) polarization.	Curcumin	33-41	peroxisome proliferator activated receptor gamma	Mus musculus	212-221
31048998-12	2019	Biochemical investigations showed decreased level of dopamine (DA), serotonin (5-HT) and acetylcholinesterase (AChE) in forebrain of treated pups compared to the control and curcumin groups.	Curcumin	174-182	acetylcholinesterase	Mus musculus	111-115
30036770-6	2018	These results showed that Curcumin may exert positive effects on I/R injury after OLT through activating PPARgamma by inhibiting the activation of NF-kappab pathway and remodeling the polarization of KCs.	Curcumin	26-34	peroxisome proliferator activated receptor gamma	Mus musculus	105-114
29746885-6	2018	In mouse primary HSCs, curcumin prevented succinate- and CoCl2-induced hypoxia-inducible transcription factor-1alpha (HIF-1alpha) induction via suppression of ROS production and effectively reduced gene expressions of Col1alpha, Col3alpha, fibronectin and TGF-beta1 with inflammation inhibition.	Curcumin	23-31	transforming growth factor, beta 1	Mus musculus	256-265
29579407-11	2018	Co-incubation of higher concentrations of curcumin (1 and 3 muM) with ketamine markedly decreased cytotoxicity, apoptosis rate, caspase-3 activity, and ROS production in rat thymocytes, and increased the MMP.	Curcumin	42-50	caspase 3	Rattus norvegicus	128-137
31062527-0	2019	Anti-Migration and Anti-Invasion Effects of Curcumin via Suppression of Fascin Expression in Glioblastoma Cells.	Curcumin	44-52	fascin actin-bundling protein 1	Homo sapiens	72-78
29917258-9	2018	Also, the increased protein expression of NGF indicated that the curcumin could offer neuroprotection for bladder against cisplatin.	Curcumin	65-73	nerve growth factor	Rattus norvegicus	42-45
30018000-6	2018	The curcumin treatment increased expression of compact myelin proteins (MPZ and PMP22), myelin sheath thickness and, correspondingly, increased motor and sensitive nerve conduction velocity.	Curcumin	4-12	myelin protein zero	Rattus norvegicus	72-75
31062527-3	2019	The purpose of this study was to investigate anti-migration and anti-invasion effects of curcumin via suppression of fascin expression in GBM cells.	Curcumin	89-97	fascin actin-bundling protein 1	Homo sapiens	117-123
29961171-0	2018	Curcumin Attenuates Airway Inflammation and Airway Remolding by Inhibiting NF-kappaB Signaling and COX-2 in Cigarette Smoke-Induced COPD Mice.	Curcumin	0-8	cytochrome c oxidase II, mitochondrial	Mus musculus	99-104
29961171-6	2018	Further investigation demonstrated an underlying molecular mechanism for the therapeutic effects of curcumin may rely on the inhibition of the degradation of IkappaBalpha and COX-2 expression in curcumin+LC-treated COPD mice and LPS-stimulated BEAS-2B cells.	Curcumin	100-108	cytochrome c oxidase II, mitochondrial	Mus musculus	175-180
31062527-9	2019	RESULTS: At various concentrations of curcumin and exposure times, fascin expression decreased.	Curcumin	38-46	fascin actin-bundling protein 1	Homo sapiens	67-73
29961171-6	2018	Further investigation demonstrated an underlying molecular mechanism for the therapeutic effects of curcumin may rely on the inhibition of the degradation of IkappaBalpha and COX-2 expression in curcumin+LC-treated COPD mice and LPS-stimulated BEAS-2B cells.	Curcumin	195-203	cytochrome c oxidase II, mitochondrial	Mus musculus	175-180
31062527-10	2019	After temporarily exposure to 10 muM/L curcumin during 6 hours as less invasive concentration and time, fascin expression temporarily decreased at 12 hours (18.4%, p=0.024), and since then recovered.	Curcumin	39-47	fascin actin-bundling protein 1	Homo sapiens	104-110
30056019-10	2018	Curcumin treatment also resulted in a decrease in anti-apoptotic proteins, p-Akt, Akt, Bcl-2 and p-Bad, and increase in pro-apoptotic proteins Bad and c-PARP levels in the control cells but not in the HSP27-KD cells.	Curcumin	0-8	collagen type XI alpha 2 chain	Homo sapiens	153-157
29723631-5	2018	Furthermore, changes in expression of the ER Stress Response (ERSR) genes IRE1 and ATF6, and the microRNAs (miRNAs) miR-27a, miR-222, miR-449 was observed after exposure to curcumin.	Curcumin	173-181	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	74-78
31062527-14	2019	CONCLUSION: Curcumin is likely to suppress the fascin expression in GBM cells, and this might be a possible mechanism for anti-migration and anti-invasion effects of Curcumin via inhibition of STAT3 phosphorylation.	Curcumin	12-20	fascin actin-bundling protein 1	Homo sapiens	47-53
29887570-0	2018	Curcumin downregulates 8-br-cAMP-induced steroidogenesis in mouse Leydig cells by suppressing the expression of Cyp11a1 and StAR independently of the PKA-CREB pathway.	Curcumin	0-8	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	112-119
31062527-14	2019	CONCLUSION: Curcumin is likely to suppress the fascin expression in GBM cells, and this might be a possible mechanism for anti-migration and anti-invasion effects of Curcumin via inhibition of STAT3 phosphorylation.	Curcumin	166-174	fascin actin-bundling protein 1	Homo sapiens	47-53
29770869-6	2018	Autocrine GH-induced curcumin resistance was overcome in a dose-dependent manner and curcumin inhibited cell proliferation, invasion-metastasis and phosphorylation of p65 (Ser536), and thereby partly prevented its DNA binding activity in breast cancer cells.	Curcumin	85-93	RELA proto-oncogene, NF-kB subunit	Homo sapiens	167-170
29860655-8	2018	Amifostine, curcumin, and melatonin reduced the increases in serum urea and serum creatinine levels following cisplatin administration and reduced the levels of TNS, HPS, NF-kappaB/p65, 8-OHdG, and caspase-3 expressions (p &lt; 0.05).	Curcumin	12-20	RELA proto-oncogene, NF-kB subunit	Homo sapiens	181-184
30942162-7	2019	We examined concentration-dependent cytotoxic, genotoxic, apoptotic, and ROS generating effects of curcumin at C-6 cells and L-929 cells.	Curcumin	99-107	complement component 6	Mus musculus	111-114
29849119-6	2018	Furthermore, co-treatment with PP242 and curcumin-induced the downregulation of the Rictor (an mTORC2 complex protein) and Akt protein levels, and ectopic overexpression of Rictor or Akt inhibited PP242 plus curcumin induced cell death.	Curcumin	41-49	CREB regulated transcription coactivator 2	Mus musculus	95-101
29770869-8	2018	In addition, transient silencing of SSAT prevented curcumin-induced cell viability loss and apoptotic cell death in each breast cancer cells.	Curcumin	51-59	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	36-40
29533214-8	2018	In addition, treatment of breast cancer cells with J1 revealed that, in contrast to the expression of cyclin B1, this curcumin analogue vigorously decreased the expression of cyclin A, CDK2 and cyclin E and subsequently sensitized tumor cells to cell cycle arrest.	Curcumin	118-126	cyclin dependent kinase 2	Homo sapiens	185-189
30242738-4	2018	Further, it was observed from the studies on release rate that microsponges filled in hard gelatin capsule shells (batch MS4) showed 93.2% release of curcumin whereas pure curcumin filled in capsule showed only 11.7% release in 8 h study.	Curcumin	150-158	MS4	Homo sapiens	121-124
29901190-10	2018	Curcumin reduced cell cycle protein expression by inhibiting smad2/3, p38 mitogen-activated protein kinase, and ERK phosphorylation in TGF-beta1-treated CFs.	Curcumin	0-8	SMAD family member 2	Homo sapiens	61-68
30887133-8	2019	Curcumin-resveratrol-gelucire 50/13-HPbetaCD (CRG-CD) and curcumin-resveratrol-gelucire 50/13(CRG) SLNs showed a particle size from 100 to 150 nm and were not in the crystalline state per PXRD results.	Curcumin	0-8	chromodomain helicase DNA binding protein 7	Homo sapiens	46-49
30004453-0	2018	Transcriptional Activation of Human GD3 Synthase (hST8Sia I) Gene in Curcumin-Induced Autophagy in A549 Human Lung Carcinoma Cells.	Curcumin	69-77	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	50-59
30004453-3	2018	In parallel with autophagy induction, the gene expression of human GD3 synthase (hST8Sia I) responsible for ganglioside GD3 synthesis was markedly elevated in response to curcumin in the A549 cells.	Curcumin	171-179	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	81-90
30004453-5	2018	Deletion analysis demonstrated that the -1146 to -646 region, which includes the putative c-Ets-1, CREB, AP-1, and NF-kappaB binding sites, functions as the curcumin-responsive promoter of hST8Sia I in A549 cells.	Curcumin	157-165	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	189-198
30004453-6	2018	The site-directed mutagenesis and chromatin immunoprecipitation assay demonstrated that the NF-kappaB binding site at -731 to -722 was indispensable for the curcumin-induced hST8Sia I gene expression in A549 cells.	Curcumin	157-165	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	174-183
30004453-7	2018	Moreover, the transcriptional activation of hST8Sia I by the curcumin A549 cells was strongly inhibited by compound C, an inhibitor of AMP-activated protein kinase (AMPK).	Curcumin	61-69	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	44-53
30004453-8	2018	These results suggest that curcumin controls hST8Sia I gene expression via AMPK signal pathway in A549 cells.	Curcumin	27-35	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	45-54
29715758-0	2018	NGF and PI3K/Akt signaling participate in the ventral motor neuronal protection of curcumin in sciatic nerve injury rat models.	Curcumin	83-91	nerve growth factor	Rattus norvegicus	0-3
29715758-4	2018	In the present study, we attempt to investigate underlying mechanism of neuroprotective effect of curcumin through elucidating its correlation with NGF and PI3K/Akt signaling pathways in vitro and in vivo.	Curcumin	98-106	nerve growth factor	Rattus norvegicus	148-151
29715758-11	2018	ProNGF level was significantly decreased while mature NGF level was increased with curcumin treatment.	Curcumin	83-91	nerve growth factor	Rattus norvegicus	3-6
29715758-12	2018	When NGF was suppressed, anti-apoptotic effect of curcumin was attenuated.	Curcumin	50-58	nerve growth factor	Rattus norvegicus	5-8
29715758-15	2018	CONCLUSION: Our findings revealed that curcumin exerts its protective effect against injured neurons through stimulating NGF release which further activates TrkA and PI3K/Akt cell survival signaling.	Curcumin	39-47	nerve growth factor	Rattus norvegicus	121-124
29620257-9	2018	This inhibition was accompanied by decreased activation of the EGFR/AKT/STAT3 pathway and reduced EGFR expression, which indicated that curcumin may have a dual role in interfering with the EGFR signaling pathway and inhibiting mucin expression in human airway epithelial cells.	Curcumin	136-144	LOC100508689	Homo sapiens	228-233
30070342-0	2018	Effects of curcumin on the role of MMP-2 in endometrial cancer cell proliferation and invasion.	Curcumin	11-19	matrix metallopeptidase 2	Homo sapiens	35-40
30070342-5	2018	Pearson"s analysis was used to determine the relationship of curcumin concentration between MMP-2 mRNA.	Curcumin	61-69	matrix metallopeptidase 2	Homo sapiens	92-97
30070342-10	2018	Pearson analysis revealed that the curcumin concentration was negatively correlated with the MMP-2 mRNA (r=-0.497, p=0.036).	Curcumin	35-43	matrix metallopeptidase 2	Homo sapiens	93-98
30070342-15	2018	CONCLUSIONS: Curcumin can downregulate MMP-2, inhibit the proliferation and invasion of cancer cells.	Curcumin	13-21	matrix metallopeptidase 2	Homo sapiens	39-44
29677548-11	2018	Additionally, the phosphorylation levels of AKT and ERK2 were both increased by combination of curcumin and VNS compared with the CI/RI + VNS group.	Curcumin	95-103	mitogen activated protein kinase 1	Rattus norvegicus	52-56
29600521-12	2018	Of note, curcumin reduced cyclinD-expression in breast cancer cell treated with thrombin, and activates AMPK in a time-dependent manner.	Curcumin	9-17	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	104-108
30001775-0	2018	Curcumin inhibits proliferation and enhances apoptosis in A549 cells by downregulating lncRNA UCA1.	Curcumin	0-8	urothelial cancer associated 1	Homo sapiens	94-98
30887133-8	2019	Curcumin-resveratrol-gelucire 50/13-HPbetaCD (CRG-CD) and curcumin-resveratrol-gelucire 50/13(CRG) SLNs showed a particle size from 100 to 150 nm and were not in the crystalline state per PXRD results.	Curcumin	58-66	chromodomain helicase DNA binding protein 7	Homo sapiens	94-97
30001775-10	2018	Curcumin (0.6 muM) significantly reduced BrdU+-positive cells, declined the expression of CyclinD1, and enhanced cell apoptosis.	Curcumin	0-8	cyclin D1	Homo sapiens	90-98
30001775-11	2018	Interestingly, we found that curcumin inhibited the expression of UCA1 and UCA1 overexpression abolished the effect of curcumin on cell apoptosis.	Curcumin	29-37	urothelial cancer associated 1	Homo sapiens	66-70
29600521-13	2018	Also suppression of AMPK abrogated inhibitory effect of phytosomal-curcumin on thrombin-induced cyclin D1 over-expression, suggesting that AMPK is essential for anti-proliferative effect of this agent in breast cancer.	Curcumin	67-75	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	20-24
29600521-13	2018	Also suppression of AMPK abrogated inhibitory effect of phytosomal-curcumin on thrombin-induced cyclin D1 over-expression, suggesting that AMPK is essential for anti-proliferative effect of this agent in breast cancer.	Curcumin	67-75	cyclin D1	Homo sapiens	96-105
29600521-13	2018	Also suppression of AMPK abrogated inhibitory effect of phytosomal-curcumin on thrombin-induced cyclin D1 over-expression, suggesting that AMPK is essential for anti-proliferative effect of this agent in breast cancer.	Curcumin	67-75	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	139-143
30001775-11	2018	Interestingly, we found that curcumin inhibited the expression of UCA1 and UCA1 overexpression abolished the effect of curcumin on cell apoptosis.	Curcumin	29-37	urothelial cancer associated 1	Homo sapiens	75-79
30001775-11	2018	Interestingly, we found that curcumin inhibited the expression of UCA1 and UCA1 overexpression abolished the effect of curcumin on cell apoptosis.	Curcumin	119-127	urothelial cancer associated 1	Homo sapiens	66-70
30936718-10	2019	Curcumin dose-dependently inhibited the proliferation, migration, and invasion of MG-63 cells and induced arrest of the G0/G1 phase and apoptosis by inhibiting the p-JAK2/p-STAT3 pathway.	Curcumin	0-8	Janus kinase 2	Homo sapiens	166-170
30001775-11	2018	Interestingly, we found that curcumin inhibited the expression of UCA1 and UCA1 overexpression abolished the effect of curcumin on cell apoptosis.	Curcumin	119-127	urothelial cancer associated 1	Homo sapiens	75-79
30001775-12	2018	In addition, we also found that curcumin inhibited Wnt and mTOR pathways through down-regulation of UCA1.	Curcumin	32-40	urothelial cancer associated 1	Homo sapiens	100-104
30001775-13	2018	CONCLUSION: We demonstrated that curcumin inhibited the growth of A549 cells through downregulation of UCA1, which might provide new insight for the treatment of lung cancer.	Curcumin	33-41	urothelial cancer associated 1	Homo sapiens	103-107
30009570-8	2018	Moreover, curcumin treatment also increased hepatic pACC/ACC, ApoB100, and SOD1 protein, and decreased hepatic FGF-21 levels; whereas, curcumin prevention increased hepatic glutathione levels.	Curcumin	10-18	fibroblast growth factor 21	Rattus norvegicus	111-117
30009570-9	2018	Both curcumin prevention and treatment reduced molecular markers of hepatic fibrosis (Col1a1 mRNA) and inflammation (TNF-alpha, SPP1 mRNA).	Curcumin	5-13	secreted phosphoprotein 1	Rattus norvegicus	128-132
29751106-10	2018	Furthermore, curcumin induced AKR1C2, an important enzyme for progesterone metabolism.	Curcumin	13-21	aldo-keto reductase family 1 member C2	Homo sapiens	30-36
29938313-0	2018	The Effect of BSA-Based Curcumin Nanoparticles on Memory and Hippocampal MMP-2, MMP-9, and MAPKs in Adult Mice.	Curcumin	24-32	matrix metallopeptidase 9	Mus musculus	80-85
29938313-11	2018	This study indicates that breaking curcumin to nanosize produces improved effects on passive avoidance memory in adult mice accompanied with MMP-2, MMP-9, p-ERK, and p-JNK changes in the hippocampus.	Curcumin	35-43	matrix metallopeptidase 9	Mus musculus	148-153
30936718-12	2019	In vivo study suggested that curcumin suppressed tumor growth through JAK2/STAT3 signaling.	Curcumin	29-37	Janus kinase 2	Homo sapiens	70-74
29899429-6	2018	Curcumin suppressed eIF2alpha phosphorylation, which is induced by endoplasmic reticulum (ER) stress, macrophage accumulation and nuclear factor-kappaB (NF-kappaB) p65 and leptin expression, whereas it"s anti-inflammatory effect was inadequate to decrease TNF-alpha and IFN-gamma levels.	Curcumin	0-8	eukaryotic translation initiation factor 2A	Mus musculus	20-29
30841433-13	2019	Moreover, curcumin could inhibit RECK methylation, thereby abates the expression of MMPs, and suppresses the tumor progression and metastasis of WT.	Curcumin	10-18	matrix metallopeptidase 2	Homo sapiens	84-88
29800814-0	2018	Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells: implications for the inhibition of protein synthesis and TNFalpha signaling.	Curcumin	21-29	CREB regulated transcription coactivator 1	Mus musculus	53-59
30668434-11	2019	Furthermore, PTX plus curcumin most impressively activated caspase-3, effector of apoptosis pathways, and reduced the expression of the anti-apoptotic protein Bcl-2.	Curcumin	22-30	caspase 3	Rattus norvegicus	59-68
29800814-4	2018	The objective of the study was to determine whether curcumin and piperine have individual and combined effects in the setting of gut inflammation by regulating mTORC1 in human intestinal epithelial cells.	Curcumin	52-60	CREB regulated transcription coactivator 1	Mus musculus	160-166
29800814-5	2018	Results show that curcumin repressed (a) mTORC1 activity (measured as changes in the phosphorylation state of p70 ribosomal protein S6 kinase B1 and 40S ribosomal protein S6) in a dose-dependent manner (2.5-20 muM, P&lt;.007) and (b) synthesis of nascent proteins.	Curcumin	18-26	CREB regulated transcription coactivator 1	Mus musculus	41-47
29800814-7	2018	The combination of curcumin + piperine further repressed mTORC1 signaling (P&lt;.02).	Curcumin	19-27	CREB regulated transcription coactivator 1	Mus musculus	57-63
29800814-8	2018	Mechanistically, curcumin may repress mTORC1 by preventing TSC2 degradation, the conserved inhibitor of mTORC1.	Curcumin	17-25	CREB regulated transcription coactivator 1	Mus musculus	38-44
29800814-8	2018	Mechanistically, curcumin may repress mTORC1 by preventing TSC2 degradation, the conserved inhibitor of mTORC1.	Curcumin	17-25	CREB regulated transcription coactivator 1	Mus musculus	104-110
29800814-12	2018	We conclude that curcumin and piperine, either alone or in combination, have the potential to down-regulate mTORC1 signaling in the intestinal epithelium with implications for tumorigenesis and inflammation.	Curcumin	17-25	CREB regulated transcription coactivator 1	Mus musculus	108-114
29890691-8	2018	Cyclin dependent kinase 2 (CDK2), a major cell cycle protein, was identified as a potential molecular target of Curcumin.	Curcumin	112-120	cyclin dependent kinase 2	Homo sapiens	0-25
29890691-8	2018	Cyclin dependent kinase 2 (CDK2), a major cell cycle protein, was identified as a potential molecular target of Curcumin.	Curcumin	112-120	cyclin dependent kinase 2	Homo sapiens	27-31
29890691-9	2018	Furthermore, Curcumin induced G1 cell cycle arrest, which is regulated by CDK2 in cancer cells.	Curcumin	13-21	cyclin dependent kinase 2	Homo sapiens	74-78
29890691-10	2018	Therefore, we used molecular modelling to study in silico the possible inhibitory effect of CDK2 by Curcumin derivatives as a possible mechanism of these compounds as anticancer agents.	Curcumin	100-108	cyclin dependent kinase 2	Homo sapiens	92-96
29723552-0	2018	PI3K/Akt/GSK3beta induced CREB activation ameliorates arsenic mediated alterations in NMDA receptors and associated signaling in rat hippocampus: Neuroprotective role of curcumin.	Curcumin	170-178	glycogen synthase kinase 3 beta	Rattus norvegicus	9-17
29723552-5	2018	Treatment with curcumin ameliorated sodium arsenite induced alterations in the levels of NMDA receptors, its receptor subunits and synaptic proteins - pCaMKIIalpha, PSD-95 and SynGAP both in vivo and in vitro.	Curcumin	15-23	discs large MAGUK scaffold protein 4	Rattus norvegicus	165-171
30838091-10	2019	Western blot analysis suggest, curcumin induce apoptosis through the activation of caspase 9, 6, 12, PARP, CHOP and PTEN.	Curcumin	31-39	collagen type XI alpha 2 chain	Homo sapiens	101-105
29723552-5	2018	Treatment with curcumin ameliorated sodium arsenite induced alterations in the levels of NMDA receptors, its receptor subunits and synaptic proteins - pCaMKIIalpha, PSD-95 and SynGAP both in vivo and in vitro.	Curcumin	15-23	synaptic Ras GTPase activating protein 1	Rattus norvegicus	176-182
29723552-7	2018	Curcumin was found to decrease sodium arsenite induced changes in hippocampus by modulating PI3K/Akt/GSK3beta neuronal survival pathway, known to regulate various cellular events.	Curcumin	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	101-109
30838091-13	2019	But other ER resident protein like IRE1alpha, PERK and GRP78 were downregulated indicating curcumin disturbs ER homeostasis.	Curcumin	91-99	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	35-44
29604245-7	2018	In SNP-treated chondrocytes, curcumin downregulated the expression of Bax and cleaved caspase-3 but upregulated the expression of Bcl-2, as shown by western blot.	Curcumin	29-37	apoptosis regulator BAX	Oryctolagus cuniculus	70-73
30611528-0	2019	Curcumin represses adipogenic differentiation of human bone marrow mesenchymal stem cells via inhibiting kruppel-like factor 15 expression.	Curcumin	0-8	Kruppel like factor 15	Homo sapiens	105-127
29942246-6	2018	Results: Results showed that in spite of high degradation rates, boiled curcumin mixture still possessed similar protective activities like parent curcumin, and could effectively rescue PC12 cells against H2O2-induced damage, via decreasing production of reactive oxygen species and malondialdehyde, reducing caspase-3 and caspase-9 activities.	Curcumin	72-80	caspase 3	Rattus norvegicus	309-318
29887802-8	2018	Transcription factor Nrf2, its downstream genes such as GSTA3, and GSTM2 mRNA, and protein expression level significantly upregulated via dietary curcumin.	Curcumin	146-154	glutathione S-transferase mu 2	Homo sapiens	67-72
30611528-8	2019	Importantly, curcumin can also suppress the expression of Kruppel-like factor 15, which may bind to the PPARgamma promoter, resulting in downregulation of PPARgamma expression to inhibit the adipogenic differentiation of hMSCs.	Curcumin	13-21	Kruppel like factor 15	Homo sapiens	58-80
30551030-8	2019	The stress-induced activation of indolamine-2, 3-dioxygenase (IDO) and an increased kynurenine/tryptophan ratio were also ameliorated by curcumin supplementation.	Curcumin	137-145	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	33-60
30551030-8	2019	The stress-induced activation of indolamine-2, 3-dioxygenase (IDO) and an increased kynurenine/tryptophan ratio were also ameliorated by curcumin supplementation.	Curcumin	137-145	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	62-65
30346064-4	2019	In short-term experiments, the combination of UA + Curc given topically prior to 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited activation of epidermal EGFR, p70S6K, NF-kappaB p50, Src, c-Jun, Rb, and IkappaBalpha.	Curcumin	51-55	jun proto-oncogene	Mus musculus	206-211
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P&lt;0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P&gt;0.05).	Curcumin	48-56	notch 2	Mus musculus	414-421
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P&lt;0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P&gt;0.05).	Curcumin	91-99	notch 2	Mus musculus	414-421
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P&lt;0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P&gt;0.05).	Curcumin	91-99	notch 2	Mus musculus	414-421
31417983-12	2018	Results: GDF-9 expression of bovine COCs cultured in PF with curcumin addition (2.67 +- 0.98) was found to increase compared to those cultured without curcumin (0.50 +- 0.67) (p &lt;= 0.001).	Curcumin	61-69	growth differentiation factor 9	Bos taurus	9-14
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P&lt;0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P&gt;0.05).	Curcumin	91-99	notch 2	Mus musculus	414-421
29734652-3	2018	In this study, we have used the anionic copolymer Eudragit&amp;reg; S100 to assemble liposomes incorporating curcumin and containing either hyaluronan (Eudragit-hyaluronan liposomes) or the water-soluble dextrin Nutriose&amp;reg; FM06 (Eudragit-nutriosomes).	Curcumin	109-117	S100 calcium binding protein A1	Mus musculus	68-72
31417983-12	2018	Results: GDF-9 expression of bovine COCs cultured in PF with curcumin addition (2.67 +- 0.98) was found to increase compared to those cultured without curcumin (0.50 +- 0.67) (p &lt;= 0.001).	Curcumin	151-159	growth differentiation factor 9	Bos taurus	9-14
29644962-9	2019	Curcumin decreased the concentrations of interleukin-1beta, tumor necrosis factor-alpha and malondialdehyde, and increased the activity of glutathione peroxidase induced by OTA in the jejunal mucosa of ducks (P&amp;lt;0.05).	Curcumin	0-8	lipopolysaccharide-induced tumor necrosis factor-alpha factor	Anas platyrhynchos	41-87
29719770-0	2018	Identification of curcumin derivatives as human LMTK3 inhibitors for breast cancer: a docking, dynamics, and MM/PBSA approach.	Curcumin	18-26	lemur tyrosine kinase 3	Homo sapiens	48-53
29719770-3	2018	Due to the absence of experimental reports, the computational approach has been followed to screen LMTK3 inhibitors from natural product curcumin derivatives based on rational inhibitor design.	Curcumin	137-145	lemur tyrosine kinase 3	Homo sapiens	99-104
29644962-10	2019	Additionally, curcumin increased jejunal mucosa occludin and tight junction protein 1 mRNA and protein levels, and decreased those of rho-associated protein kinase 1 (P&amp;lt;0.05).	Curcumin	14-22	OCLN	Anas platyrhynchos	48-56
29644962-10	2019	Additionally, curcumin increased jejunal mucosa occludin and tight junction protein 1 mRNA and protein levels, and decreased those of rho-associated protein kinase 1 (P&amp;lt;0.05).	Curcumin	14-22	tight junction protein ZO-1	Anas platyrhynchos	61-85
31266378-0	2019	Curcumin inhibits the lymphangiogenesis of gastric cancer cells by inhibiton of HMGB1/VEGF-D signaling.	Curcumin	0-8	high mobility group box 1	Homo sapiens	80-85
28856444-2	2018	We determined the effect of curcumin against gastric haemorrhagic lesions induced by 75% ethanol and alterations in gastric blood flow (GBF) in rats with cyclooxygenase-1 (COX-1) and COX-2 activity inhibited by indomethacin, SC-560 or rofecoxib, inhibited NO-synthase activity, capsaicin denervation and blockade of TRPV1 receptors by capsazepine.	Curcumin	28-36	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	154-170
31266378-3	2019	However, the molecular mechanisms by which curcumin regulates HMGB1-mediated lymphangiogenesis in gastric cancer remain unclear.	Curcumin	43-51	high mobility group box 1	Homo sapiens	62-67
29408622-0	2018	Inhibition of hepatocellular carcinoma tumorigenesis by curcumin may be associated with CDKN1A and CTGF.	Curcumin	56-64	cellular communication network factor 2	Homo sapiens	99-103
31266378-5	2019	The effects of curcumin on HMGB1 and VEGF-D expression were examined by reverse transcription polymerase chain reaction (RT-PCR) and western blot analysis.	Curcumin	15-23	high mobility group box 1	Homo sapiens	27-32
29408622-5	2018	Finally, we detected the expression of CDKN1A, CTGF, LEF1 TF and MIR-19A regulated by curcumin in PLC/PRF/5 cells using RT-PCR.	Curcumin	86-94	cellular communication network factor 2	Homo sapiens	47-51
31266378-7	2019	The mRNA and protein expression levels of HMGB1 and VEGF-D were significantly eliminated by curcumin administration.	Curcumin	92-100	high mobility group box 1	Homo sapiens	42-47
29408622-5	2018	Finally, we detected the expression of CDKN1A, CTGF, LEF1 TF and MIR-19A regulated by curcumin in PLC/PRF/5 cells using RT-PCR.	Curcumin	86-94	lymphoid enhancer binding factor 1	Homo sapiens	53-57
31266378-8	2019	Pre-treatment with the recombinant HMGB1 (rHMGB1) markedly abolished curcumin-reduced VEGF-D expression.	Curcumin	69-77	high mobility group box 1	Homo sapiens	35-40
29408622-12	2018	Furthermore, the expression of CDKN1A, CTGF, LEF1 TF and miR-19A regulated by curcumin in PLC/PRF/5 cells was consistent with the aforementioned bioinformatics analysis results.	Curcumin	78-86	cellular communication network factor 2	Homo sapiens	39-43
29408622-12	2018	Furthermore, the expression of CDKN1A, CTGF, LEF1 TF and miR-19A regulated by curcumin in PLC/PRF/5 cells was consistent with the aforementioned bioinformatics analysis results.	Curcumin	78-86	lymphoid enhancer binding factor 1	Homo sapiens	45-49
29408622-13	2018	To conclude, curcumin might exert its protective effects against HCC tumorigenesis by downregulating LEF1 and downregulating CTGF regulated by MIR-19A and upregulating CDKN1A expression.	Curcumin	13-21	lymphoid enhancer binding factor 1	Homo sapiens	101-105
31266378-9	2019	Our findings suggested that curcumin might exert anti-lymphangiogenesis in gastric cancer by inhibition of HMGB1/VEGF-D signaling.	Curcumin	28-36	high mobility group box 1	Homo sapiens	107-112
30943499-11	2019	The protein levels of c-Fos and NGF were decreased by treatment with curcumin compared with the corresponding protein levels in the BPA group.	Curcumin	69-77	nerve growth factor	Rattus norvegicus	32-35
30599890-10	2019	Further investigation of the mechanism of action of curcumin and quercetin in melanoma cells, A375, suggested that inhibition of cell proliferation occurred through down-regulation of Wnt/beta-catenin signaling pathway proteins, DVL2, beta-catenin, cyclin D1, Cox2, and Axin2.	Curcumin	52-60	cyclin D1	Homo sapiens	249-258
29408622-13	2018	To conclude, curcumin might exert its protective effects against HCC tumorigenesis by downregulating LEF1 and downregulating CTGF regulated by MIR-19A and upregulating CDKN1A expression.	Curcumin	13-21	cellular communication network factor 2	Homo sapiens	125-129
30599890-11	2019	In addition, both curcumin and quercetin induced apoptosis by down-regulating BCL2 and inducing caspase 3/7 through PARP cleavage.	Curcumin	18-26	collagen type XI alpha 2 chain	Homo sapiens	116-120
29657313-0	2018	Curcumin Attenuates Inflammation in a Severe Acute Pancreatitis Animal Model by Regulating TRAF1/ASK1 Signaling.	Curcumin	0-8	TNF receptor-associated factor 1	Rattus norvegicus	91-96
29339038-0	2018	Curcumin inhibits TGF-beta1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts.	Curcumin	0-8	cellular communication network factor 2	Homo sapiens	36-67
29657313-11	2018	Pre-treatment with curcumin reduced the expression level of TNF receptor-associated factor 1 (TRAF1), IL6, and TNFa in pancreas in SAP rats.	Curcumin	19-27	TNF receptor-associated factor 1	Rattus norvegicus	60-92
29657313-11	2018	Pre-treatment with curcumin reduced the expression level of TNF receptor-associated factor 1 (TRAF1), IL6, and TNFa in pancreas in SAP rats.	Curcumin	19-27	TNF receptor-associated factor 1	Rattus norvegicus	94-99
29339038-0	2018	Curcumin inhibits TGF-beta1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts.	Curcumin	0-8	SMAD family member 2	Homo sapiens	107-112
29549176-4	2018	We report that curcumin inhibited caspase-1 activation and IL-1beta secretion through suppressing LPS priming and the inflammasome activation pathway in mouse bone marrow-derived macrophages.	Curcumin	15-23	caspase 1	Mus musculus	34-43
29339038-5	2018	This study was aimed to evaluate whether curcumin could suppress TGF-beta1-induced CTGF expression and its related signaling pathway involving in this inhibitory action in primary human gingival fibroblasts.	Curcumin	41-49	cellular communication network factor 2	Homo sapiens	83-87
29339038-8	2018	The effect of curcumin on TGF-beta1-induced CTGF expression in primary human gingival fibroblasts was examined by immunoblotting.	Curcumin	14-22	cellular communication network factor 2	Homo sapiens	44-48
29339038-12	2018	Curcumin was nontoxic and could reduce TGF-beta1-induced CTGF expression by attenuating the phosphorylation and nuclear translocation of Smad2.	Curcumin	0-8	cellular communication network factor 2	Homo sapiens	57-61
29191105-0	2018	Curcumin and its derivatives inhibit 2,3,7,8,-tetrachloro-dibenzo-p-dioxin-induced expression of drug metabolizing enzymes through aryl hydrocarbon receptor-mediated pathway.	Curcumin	0-8	aryl hydrocarbon receptor	Homo sapiens	131-156
29191105-2	2018	In this study, we examined the effect of curcumin on expression of drug-metabolizing enzymes through the AhR and NF-E2 related factor 2 (Nrf2) pathways.	Curcumin	41-49	aryl hydrocarbon receptor	Homo sapiens	105-108
29339038-12	2018	Curcumin was nontoxic and could reduce TGF-beta1-induced CTGF expression by attenuating the phosphorylation and nuclear translocation of Smad2.	Curcumin	0-8	SMAD family member 2	Homo sapiens	137-142
29191105-3	2018	Curcumin dose-dependently inhibited TCDD-induced expression of phase I enzyme cytochrome P450 1A1 (CYP1A1) and phase II enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase 1 (HO-1) but not tert-butyl hydroquinone-induced NQO1 and HO-1, suggesting that curcumin inhibited only AhR pathway, but not Nrf2 one directly.	Curcumin	0-8	aryl hydrocarbon receptor	Homo sapiens	291-294
29191105-4	2018	Furthermore, we used 14 curcumin derivatives and obtained the correlation between hydrophobicity of the compounds and suppressive effect against AhR transformation.	Curcumin	24-32	aryl hydrocarbon receptor	Homo sapiens	145-148
29339038-13	2018	CONCLUSION: Curcumin can suppress TGF-beta1-induced CTGF expression through the interruption of Smad2 signaling.	Curcumin	12-20	cellular communication network factor 2	Homo sapiens	52-56
29339038-13	2018	CONCLUSION: Curcumin can suppress TGF-beta1-induced CTGF expression through the interruption of Smad2 signaling.	Curcumin	12-20	SMAD family member 2	Homo sapiens	96-101
30396035-9	2018	RESULTS: NLRP3 inflammasome activation was dramatically inhibited by curcumin in DSS-stimulated macrophages, as evidenced by decreased IL-1beta secretion, less caspase-1 activation and ASC specks.	Curcumin	69-77	caspase 1	Mus musculus	160-169
30396035-12	2018	Meanwhile, curcumin significantly decreased the expression of multiple inflammatory cytokines (including mature IL-1beta, IL-6, MCP-1), MPO activity, caspase-1 activity as well as histopathological damage.	Curcumin	11-19	caspase 1	Mus musculus	150-159
28849357-0	2018	Curcumin-supplemented diets improve antioxidant enzymes and alter acetylcholinesterase genes expression level in Drosophila melanogaster model.	Curcumin	0-8	Acetylcholine esterase	Drosophila melanogaster	66-86
31223206-0	2018	Structure-based analysis of curcumin and conventionaldrugs targeting tumor-inducing protein PHF20.	Curcumin	28-36	PHD finger protein 20	Homo sapiens	92-97
28849357-2	2018	Hence, this study sought to examine the antioxidant and anti-cholinesterase activities of curcumin-supplemented diets as well as their molecular effect on superoxide dismutase (SOD) and acetylcholinesterase (AChE) genes expression level associated with lifespan extension in Drosophila melanogaster model.	Curcumin	90-98	Acetylcholine esterase	Drosophila melanogaster	186-206
28849357-2	2018	Hence, this study sought to examine the antioxidant and anti-cholinesterase activities of curcumin-supplemented diets as well as their molecular effect on superoxide dismutase (SOD) and acetylcholinesterase (AChE) genes expression level associated with lifespan extension in Drosophila melanogaster model.	Curcumin	90-98	Acetylcholine esterase	Drosophila melanogaster	208-212
28849357-9	2018	Furthermore, curcumin-supplemented diets suppress AChE mRNA expression but no alteration on SOD gene expression level was observed when compared with control.	Curcumin	13-21	Acetylcholine esterase	Drosophila melanogaster	50-54
28849357-10	2018	In conclusion, our present results suggest that a down-regulation of AChE gene expression with a concomitant decrease of AChE activity as well as improving antioxidant status could be some possible mechanism in which curcumin exert anti-aging potential and increases lifespan of D. melanogaster.	Curcumin	217-225	Acetylcholine esterase	Drosophila melanogaster	69-73
28849357-10	2018	In conclusion, our present results suggest that a down-regulation of AChE gene expression with a concomitant decrease of AChE activity as well as improving antioxidant status could be some possible mechanism in which curcumin exert anti-aging potential and increases lifespan of D. melanogaster.	Curcumin	217-225	Acetylcholine esterase	Drosophila melanogaster	121-125
29460119-0	2018	Curcumin Inhibits Monocyte Chemoattractant Protein-1 Expression in TNF-alpha induced Astrocytes Through AMPK Pathway.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	104-108
29460119-6	2018	Our data demonstrated that Curcumin inhibited TNF-alpha-induced astrocytes migration, decreased MCP-1 expression, and up-regulated SOD2 expression in TNF-alpha-induced astrocytes in vitro.	Curcumin	27-35	superoxide dismutase 2	Homo sapiens	131-135
29923222-7	2018	It has been showed that curcumin exerts its therapeutic effects on HBV patients via targeting a variety of cellular and molecular pathways such as Wnt/beta-catenin, Ap1, STAT3, MAPK, and NF-kappaB signaling.	Curcumin	24-32	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	165-168
29460119-7	2018	Our study also indicated that this process was mediated through the AMPK signaling pathway, as addition of Curcumin significantly increased the level of phosphorylated AMPK protein.	Curcumin	107-115	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	68-72
29923222-9	2018	Moreover, we highlighted main signaling pathways (eg, NF-kappaB, AP1, and Wnt/beta-catenin signaling) which affected by curcumin in HBV infections.	Curcumin	120-128	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-68
29460119-7	2018	Our study also indicated that this process was mediated through the AMPK signaling pathway, as addition of Curcumin significantly increased the level of phosphorylated AMPK protein.	Curcumin	107-115	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	168-172
30292723-7	2018	In addition, AMPK-mediated inhibition of mTORC1 pathway likely played a role in regulating autophagy by curcumin under diabetic condition.	Curcumin	104-112	CREB regulated transcription coactivator 1	Mus musculus	41-47
29234949-1	2018	We previously demonstrated that a PEGylated curcumin (Curc-mPEG454) significantly inhibited cyclooxygenase 2 (COX-2) expression and improved the progression of liver fibrosis.	Curcumin	44-52	prostaglandin-endoperoxide synthase 2	Mus musculus	92-108
30048777-0	2018	Curcumin-entrapped MUC-1 aptamer targeted dendrimer-gold hybrid nanostructure as a theranostic system for colon adenocarcinoma.	Curcumin	0-8	mucin 1, cell surface associated	Homo sapiens	19-24
29234949-1	2018	We previously demonstrated that a PEGylated curcumin (Curc-mPEG454) significantly inhibited cyclooxygenase 2 (COX-2) expression and improved the progression of liver fibrosis.	Curcumin	44-52	prostaglandin-endoperoxide synthase 2	Mus musculus	110-115
29673545-0	2018	Curcumin induces apoptosis and cell cycle arrest via the activation of reactive oxygen species-independent mitochondrial apoptotic pathway in Smad4 and p53 mutated colon adenocarcinoma HT29 cells.	Curcumin	0-8	SMAD family member 4	Homo sapiens	142-147
29673545-12	2018	In conclusion, our data provide the first evidence that curcumin induces ROS independent apoptosis and cell cycle arrest in colon cancer cells that carry mutation on Smad4 and p53.	Curcumin	56-64	SMAD family member 4	Homo sapiens	166-171
30048777-6	2018	The curcumin-loaded PEGylated Au dendrimer was further conjugated to MUC-1 aptamer in order to target the colorectal adenocarcinoma in vitro and in vivo.	Curcumin	4-12	mucin 1, cell surface associated	Homo sapiens	69-74
30048777-9	2018	Findings from this study suggested that MUC-1 targeted curcumin-loaded PEGylated Au dendrimers have good X-ray attenuation and is desirable probe for CT imaging while demonstrating high therapeutic index against colorectal cancer adenocarcinoma.	Curcumin	55-63	mucin 1, cell surface associated	Homo sapiens	40-45
31516880-5	2018	In this study, we evaluated the effects of curcumin treatment on the regulation of IL-4 and IL-13, DUOX1 &amp; 2 genes as well as the pathological changes developed by this treatment.	Curcumin	43-51	interleukin 4	Rattus norvegicus	83-87
29454324-10	2018	Correspondingly, the mRNA expression of caspase-3, Bax, and Cox-2 was lower in the curcumin group than in the model group (P &lt; 0.05).	Curcumin	83-91	caspase 3	Rattus norvegicus	40-49
29454324-10	2018	Correspondingly, the mRNA expression of caspase-3, Bax, and Cox-2 was lower in the curcumin group than in the model group (P &lt; 0.05).	Curcumin	83-91	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	60-65
31516880-13	2018	Treatment with curcumin downregulated the expression of IL-4, IL4Ra1, DUOX1 &amp; 2.	Curcumin	15-23	interleukin 4	Rattus norvegicus	56-60
29065834-0	2018	Polymeric Nano-Encapsulation of Curcumin Enhances its Anti-Cancer Activity in Breast (MDA-MB231) and Lung (A549) Cancer Cells Through Reduction in Expression of HIF-1alpha and Nuclear p65 (Rel A).	Curcumin	32-40	RELA proto-oncogene, NF-kB subunit	Homo sapiens	184-187
29887570-4	2018	Furthermore, our real-time PCR, Western blot, and 22R-OHC/pregnenolone supplementing experiment data demonstrated that curcumin suppressed 8-br-cAMP-induced steroidogenesis in Leydig cells by inhibiting the expression of StAR and Cyp11a1.	Curcumin	119-127	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	230-237
29065834-0	2018	Polymeric Nano-Encapsulation of Curcumin Enhances its Anti-Cancer Activity in Breast (MDA-MB231) and Lung (A549) Cancer Cells Through Reduction in Expression of HIF-1alpha and Nuclear p65 (Rel A).	Curcumin	32-40	RELA proto-oncogene, NF-kB subunit	Homo sapiens	189-194
29065834-8	2018	RESULTS: A ten-fold increase in solubility, three-fold increase in anti-cancer activity and a significant reduction in the levels of cellular HIF-1alpha and nuclear p65 (Rel A) were observed for cur-PLGA-NP, when compared to free curcumin.	Curcumin	230-238	RELA proto-oncogene, NF-kB subunit	Homo sapiens	170-175
29065834-9	2018	CONCLUSION: Our findings indicate that curcumin can effectively lower the elevated levels of HIF-1alpha and nuclear p65 (Rel A) in breast and lung cancer cells under an hypoxic tumour micro-environment when delivered in nanoparticulate form.	Curcumin	39-47	RELA proto-oncogene, NF-kB subunit	Homo sapiens	116-119
29887570-6	2018	On the contrary, the real-time PCR results showed that curcumin suppressed 8-br-cAMP-induced expression of Nr5a1 and Fos, which are crucial for cAMP-stimulated StAR and Cyp11a1 expression in Leydig cells.	Curcumin	55-63	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	169-176
29065834-9	2018	CONCLUSION: Our findings indicate that curcumin can effectively lower the elevated levels of HIF-1alpha and nuclear p65 (Rel A) in breast and lung cancer cells under an hypoxic tumour micro-environment when delivered in nanoparticulate form.	Curcumin	39-47	RELA proto-oncogene, NF-kB subunit	Homo sapiens	121-126
29440765-8	2018	In addition to baicalin treatment, we found that the hypoxia-response protein DEPP functions as a positive regulator involving the regulations of Ras/Raf/MEK/ERK signaling pathway and inhibition of human colon cancer by other anti-oxidative drugs, such as curcumin and sulforaphane, resulting in tumor cellular senescence.	Curcumin	256-264	zinc fingers and homeoboxes 2	Homo sapiens	150-153
29887570-7	2018	Collectively, our data demonstrated that curcumin may suppress cAMP-induced steroidogenesis in mouse Leydig cells by down-regulating Nr5a1/Fos-controlled StAR and Cyp11a1 expression independently of the PKA-CREB signaling pathway.	Curcumin	41-49	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	163-170
30138353-3	2018	Previous studies demonstrated that curcumin can inhibit ornithine decarboxylase (ODC) activity in human leukemia and breast cancer cells, and pretreatment with dietary curcumin blocks carcinogen-induced ODC activity in rodent models of skin, colon, and renal cancer.	Curcumin	35-43	ornithine decarboxylase 1	Homo sapiens	56-79
28872777-10	2018	The increase in the PICs was blocked by AP1 blocker curcumin.	Curcumin	52-60	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	40-43
29422835-13	2017	The nano-curcumin treatment inhibited the activation of SGCs accompanied by its anti-inflammatory effect to decrease the up-regulated CGRP expression in the DRG neurons.	Curcumin	9-17	calcitonin-related polypeptide alpha	Rattus norvegicus	134-138
29901626-14	2018	Moreover, curcumin significantly increased inositol-requiring enzyme 1alpha (IRE1alpha) phosphorylation and XBP-1 mRNA splicing to induce a subsets of ER chaperones.	Curcumin	10-18	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	77-86
29901626-16	2018	Furthermore, curcumin induced intracellular Ca influx through inhibition of the sarco-endoplasmic reticulum ATPase 2A (SERCA2) pump.	Curcumin	13-21	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	80-117
29901626-16	2018	Furthermore, curcumin induced intracellular Ca influx through inhibition of the sarco-endoplasmic reticulum ATPase 2A (SERCA2) pump.	Curcumin	13-21	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	119-125
30693689-6	2018	RESULTS: Compared with MPTP model group, curcumin increased the number of surviving dopamine neurons(P<0.01), decreased both protein expression and mRNA expression of alpha-Syn (all P<0.01), and increased protein expression of TFEB, LAMP2A and LC3-II (all P<0.01).	Curcumin	41-49	transcription factor EB	Homo sapiens	227-231
30693689-7	2018	When curcumin and 3-MA were given concurrently, the number of surviving dopamine neurons, protein expression of TFEB, LAMP2A and LC3-II increased (P<0.05 or P<0.01), and both protein expression and mRNA expression of alpha-Syn decreased (P<0.05 or P<0.01) compared with MPTP model group; but the number of surviving dopamine neurons and protein expression of LAMP2A and LC3-II decreased compared with curcumin group (all P<0.05).	Curcumin	5-13	transcription factor EB	Homo sapiens	112-116
30138353-3	2018	Previous studies demonstrated that curcumin can inhibit ornithine decarboxylase (ODC) activity in human leukemia and breast cancer cells, and pretreatment with dietary curcumin blocks carcinogen-induced ODC activity in rodent models of skin, colon, and renal cancer.	Curcumin	35-43	ornithine decarboxylase 1	Homo sapiens	81-84
30138353-3	2018	Previous studies demonstrated that curcumin can inhibit ornithine decarboxylase (ODC) activity in human leukemia and breast cancer cells, and pretreatment with dietary curcumin blocks carcinogen-induced ODC activity in rodent models of skin, colon, and renal cancer.	Curcumin	168-176	ornithine decarboxylase 1	Homo sapiens	56-79
29700289-0	2018	RCP induces FAK phosphorylation and ovarian cancer cell invasion with inhibition by curcumin.	Curcumin	84-92	RAB11 family interacting protein 1	Homo sapiens	0-3
29700289-3	2018	In the present study, we demonstrated that FAK is implicated in RCP-induced EGFR phosphorylation and ovarian cancer cell invasion with inhibition by curcumin.	Curcumin	149-157	protein tyrosine kinase 2	Homo sapiens	43-46
30138353-3	2018	Previous studies demonstrated that curcumin can inhibit ornithine decarboxylase (ODC) activity in human leukemia and breast cancer cells, and pretreatment with dietary curcumin blocks carcinogen-induced ODC activity in rodent models of skin, colon, and renal cancer.	Curcumin	168-176	ornithine decarboxylase 1	Homo sapiens	81-84
29700289-3	2018	In the present study, we demonstrated that FAK is implicated in RCP-induced EGFR phosphorylation and ovarian cancer cell invasion with inhibition by curcumin.	Curcumin	149-157	RAB11 family interacting protein 1	Homo sapiens	64-67
29700289-5	2018	Interestingly, we observed for the first time that curcumin attenuates RCP-induced ovarian cancer cell invasion by blocking stabilization of beta1 integrin and consequently inhibiting FAK and EGFR activation, providing potential biomarkers for ovarian cancer and therapeutic approaches for this deadly disease.	Curcumin	51-59	RAB11 family interacting protein 1	Homo sapiens	71-74
29223538-8	2018	KEY FINDINGS: Curcumin increased the expression of genes such as distal-less homeobox 5 (Dlx5), runt-related transcription factor 2 (Runx2), ALP, and osteocalcin (OC), which subsequently induced osteoblast differentiation in C3H10T1/2 cells.	Curcumin	14-22	distal-less homeobox 5	Mus musculus	65-87
30138353-3	2018	Previous studies demonstrated that curcumin can inhibit ornithine decarboxylase (ODC) activity in human leukemia and breast cancer cells, and pretreatment with dietary curcumin blocks carcinogen-induced ODC activity in rodent models of skin, colon, and renal cancer.	Curcumin	168-176	ornithine decarboxylase 1	Homo sapiens	203-206
29223538-8	2018	KEY FINDINGS: Curcumin increased the expression of genes such as distal-less homeobox 5 (Dlx5), runt-related transcription factor 2 (Runx2), ALP, and osteocalcin (OC), which subsequently induced osteoblast differentiation in C3H10T1/2 cells.	Curcumin	14-22	distal-less homeobox 5	Mus musculus	89-93
29700289-5	2018	Interestingly, we observed for the first time that curcumin attenuates RCP-induced ovarian cancer cell invasion by blocking stabilization of beta1 integrin and consequently inhibiting FAK and EGFR activation, providing potential biomarkers for ovarian cancer and therapeutic approaches for this deadly disease.	Curcumin	51-59	protein tyrosine kinase 2	Homo sapiens	184-187
29731715-6	2018	Curcumin also inhibited LTA-induced inducible NO synthases (iNOS) and cyclooxygenase-2 (COX-2) expression.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	70-86
29223538-12	2018	Transient transfection studies also showed that curcumin increased ATF6-Luc activity, while decreasing the activities of CREBH-Luc and SMILE-Luc.	Curcumin	48-56	activating transcription factor 6	Mus musculus	67-71
30138353-5	2018	Curcumin treatment significantly induced spermine oxidase (SMOX) mRNA and activity, which results in the generation of hydrogen peroxide, a source of ROS.	Curcumin	0-8	spermine oxidase	Homo sapiens	41-57
29223538-14	2018	SIGNIFICANCE: Overall, these results demonstrate that curcumin-induced mild ER stress increases osteoblast differentiation via ATF6 expression in C3H10T1/2 cells.	Curcumin	54-62	activating transcription factor 6	Mus musculus	127-131
29731715-6	2018	Curcumin also inhibited LTA-induced inducible NO synthases (iNOS) and cyclooxygenase-2 (COX-2) expression.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	88-93
29731715-7	2018	Subsequently, our mechanistic studies revealed that curcumin inhibited LTA-induced phosphorylation of mitogen-activated protein kinase (MAPK) including ERK, p38, Akt and translocation of NF-kappaB.	Curcumin	52-60	mitogen-activated protein kinase 14	Mus musculus	157-160
30138353-5	2018	Curcumin treatment significantly induced spermine oxidase (SMOX) mRNA and activity, which results in the generation of hydrogen peroxide, a source of ROS.	Curcumin	0-8	spermine oxidase	Homo sapiens	59-63
30138353-6	2018	Simultaneously, curcumin down regulated spermidine/spermine N1-acetyltransferase (SSAT) activity and the biosynthetic enzymes ODC and S-adenosylmethionine decarboxylase (SAMDC), thereby diminishing intracellular polyamine pools.	Curcumin	16-24	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	40-80
28561324-5	2018	Curcumin was found to significantly abate adenine-induced toxic effects such as reduced creatinine clearance, elevated neutrophil gelatinase-associated lipocalin levels and raised urinary N-acetyl-beta-D-glucosaminidase activities.	Curcumin	0-8	lipocalin 2	Rattus norvegicus	119-161
30138353-6	2018	Simultaneously, curcumin down regulated spermidine/spermine N1-acetyltransferase (SSAT) activity and the biosynthetic enzymes ODC and S-adenosylmethionine decarboxylase (SAMDC), thereby diminishing intracellular polyamine pools.	Curcumin	16-24	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	82-86
29089332-6	2018	Evaluation of the molecular mechanisms underlying the chemopreventive and antitumor effects of curcumin revealed that NF-kappaB and STAT3 signaling pathways were significantly inhibited but that the nuclear factor erythroid 2/heme oxygenase 1 antioxidant pathway was induced by curcumin intake in a dose-dependent manner in ovarian tissues (P &lt; 0.05).	Curcumin	95-103	heme oxygenase 1	Gallus gallus	226-242
29662310-4	2018	Results: Both curcumin and curcumin/P pretreatment alleviated pathological morphological damage of myocardium, increased H2S and [Ca2+]i levels, and upregulated the expression of CaSR, CSE, and CaM as compared to DCM group, while curcumin/P remarkably augmented this effect.	Curcumin	14-22	cystathionine gamma-lyase	Rattus norvegicus	185-188
30138353-6	2018	Simultaneously, curcumin down regulated spermidine/spermine N1-acetyltransferase (SSAT) activity and the biosynthetic enzymes ODC and S-adenosylmethionine decarboxylase (SAMDC), thereby diminishing intracellular polyamine pools.	Curcumin	16-24	ornithine decarboxylase 1	Homo sapiens	126-129
29662310-4	2018	Results: Both curcumin and curcumin/P pretreatment alleviated pathological morphological damage of myocardium, increased H2S and [Ca2+]i levels, and upregulated the expression of CaSR, CSE, and CaM as compared to DCM group, while curcumin/P remarkably augmented this effect.	Curcumin	14-22	calmodulin 1	Rattus norvegicus	194-197
29662310-4	2018	Results: Both curcumin and curcumin/P pretreatment alleviated pathological morphological damage of myocardium, increased H2S and [Ca2+]i levels, and upregulated the expression of CaSR, CSE, and CaM as compared to DCM group, while curcumin/P remarkably augmented this effect.	Curcumin	27-35	cystathionine gamma-lyase	Rattus norvegicus	185-188
30138353-7	2018	Combination treatments using curcumin with the ODC inhibitor 2-difluoromethylornithine (DFMO), an agent currently in clinical chemoprevention trials, significantly enhanced inhibition of ODC activity and decreased growth of GI cancer cell lines beyond that observed with either agent alone.	Curcumin	29-37	ornithine decarboxylase 1	Homo sapiens	47-50
29662310-4	2018	Results: Both curcumin and curcumin/P pretreatment alleviated pathological morphological damage of myocardium, increased H2S and [Ca2+]i levels, and upregulated the expression of CaSR, CSE, and CaM as compared to DCM group, while curcumin/P remarkably augmented this effect.	Curcumin	27-35	calmodulin 1	Rattus norvegicus	194-197
29662310-4	2018	Results: Both curcumin and curcumin/P pretreatment alleviated pathological morphological damage of myocardium, increased H2S and [Ca2+]i levels, and upregulated the expression of CaSR, CSE, and CaM as compared to DCM group, while curcumin/P remarkably augmented this effect.	Curcumin	27-35	cystathionine gamma-lyase	Rattus norvegicus	185-188
30138353-7	2018	Combination treatments using curcumin with the ODC inhibitor 2-difluoromethylornithine (DFMO), an agent currently in clinical chemoprevention trials, significantly enhanced inhibition of ODC activity and decreased growth of GI cancer cell lines beyond that observed with either agent alone.	Curcumin	29-37	ornithine decarboxylase 1	Homo sapiens	187-190
29662310-4	2018	Results: Both curcumin and curcumin/P pretreatment alleviated pathological morphological damage of myocardium, increased H2S and [Ca2+]i levels, and upregulated the expression of CaSR, CSE, and CaM as compared to DCM group, while curcumin/P remarkably augmented this effect.	Curcumin	27-35	calmodulin 1	Rattus norvegicus	194-197
30138353-9	2018	Importantly, cotreatment with curcumin permitted the lowering of the effective dose of ODC inhibitor or polyamine analogue.	Curcumin	30-38	ornithine decarboxylase 1	Homo sapiens	87-90
29044685-10	2018	CPA caused the overexpression of CSE in the bladder, and this was prevented by PDTC or curcumin.	Curcumin	87-95	cystathionase (cystathionine gamma-lyase)	Mus musculus	33-36
29975931-22	2018	CONCLUSION: Curcumin inhibited RPE cell proliferation by downregulating EGF and thus effectively inhibited the initiation and development of PVR.	Curcumin	12-20	pro-epidermal growth factor	Oryctolagus cuniculus	72-75
30186159-0	2018	The Curcumin Analogs 2-Pyridyl Cyclohexanone Induce Apoptosis via Inhibition of the JAK2-STAT3 Pathway in Human Esophageal Squamous Cell Carcinoma Cells.	Curcumin	4-12	Janus kinase 2	Homo sapiens	84-88
29059021-10	2018	While curcumin released from supramolecular injectable hydrogels (Cur-beta-CD/EG-PF127) has the ability to show pharmacological activity and kill the cancer cells.	Curcumin	6-14	beta-carotene oxygenase 1	Mus musculus	70-77
29273065-0	2017	Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice.	Curcumin	0-8	unc-51 like kinase 1	Mus musculus	58-62
29273065-14	2017	CONCLUSION: Pre-treatment with curcumin followed by 5-Fu may mediate autophagy turnover both in vitro and in vivo via AMPK/ULK1-dependent autophagy inhibition and AKT modulation, which may account for the increased susceptibility of the colon cancer cells/xenograft to the cytotoxicity of 5-Fu.	Curcumin	31-39	unc-51 like autophagy activating kinase 1	Homo sapiens	123-127
29242172-0	2018	Curcumin enhances LXRalpha in an AMP-activated protein kinase-dependent manner in human macrophages.	Curcumin	0-8	nuclear receptor subfamily 1 group H member 3	Homo sapiens	18-26
29242172-2	2018	Curcumin, a traditional Chinese derivative from the rhizomes of Curcuma longa and a well-known AMP-activated protein kinase (AMPK) activator, possess hypocholesterolemic activity, however, the possible link between AMPK and cholesterol is unknown.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	125-129
29242172-2	2018	Curcumin, a traditional Chinese derivative from the rhizomes of Curcuma longa and a well-known AMP-activated protein kinase (AMPK) activator, possess hypocholesterolemic activity, however, the possible link between AMPK and cholesterol is unknown.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	215-219
29242172-3	2018	In this study, we have investigated whether curcumin regulates metabolic changes in cholesterol metabolism via LXRalpha in THP-1 human macrophages, the cells implicated in atheroma plaques formation.	Curcumin	44-52	nuclear receptor subfamily 1 group H member 3	Homo sapiens	111-119
29242172-4	2018	Results showed that curcumin induced AMPK phosphorylation, increased LXRalpha mRNA and protein expression.	Curcumin	20-28	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	37-41
29242172-4	2018	Results showed that curcumin induced AMPK phosphorylation, increased LXRalpha mRNA and protein expression.	Curcumin	20-28	nuclear receptor subfamily 1 group H member 3	Homo sapiens	69-77
29460119-8	2018	Furthermore, the specific AMPK activator AICAR (5-aminoimidazole-4-carboxamide 1-D-ribofuranoside) mimicked the effects of Curcumin, whereas a selective AMPK inhibitor Compound C (also called dorsomorphin) partially blocked its function.	Curcumin	123-131	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	26-30
28861684-0	2017	Curcumin revitalizes Amyloid beta (25-35)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2.	Curcumin	0-8	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	150-154
28861684-10	2017	In this study, pretreatment of curcumin to the SH-SY5Y cells enhanced the expression of DNA repair enzymes APE1, pol beta, and PARP1 enzymes to counter the oxidative DNA base damage via base excision repair (BER) pathway, and also activated the antioxidant element (ARE) via Nrf2 upregulation.	Curcumin	31-39	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	107-111
28861684-10	2017	In this study, pretreatment of curcumin to the SH-SY5Y cells enhanced the expression of DNA repair enzymes APE1, pol beta, and PARP1 enzymes to counter the oxidative DNA base damage via base excision repair (BER) pathway, and also activated the antioxidant element (ARE) via Nrf2 upregulation.	Curcumin	31-39	DNA polymerase beta	Homo sapiens	113-121
29353208-9	2018	Lower expression of SREBP-1c, pERK, TNF-alpha, and pJNK were also observed in berberine + curcumin group.	Curcumin	90-98	sterol regulatory element binding transcription factor 1	Rattus norvegicus	20-28
29629345-6	2018	Results: Administration of curcumin significantly attenuated the severity of DSS-induced colitis and the activation of NF-kappaB and STAT3 as well as expression of COX-2 and inducible nitric oxide synthase.	Curcumin	27-35	cytochrome c oxidase II, mitochondrial	Mus musculus	164-169
29954586-4	2018	Co-treatment with curcumin-I inverted these damages and exhibited a significant neuroprotective potential, thus, both TH expression and locomotor performance was reinstated in intoxicated rats.	Curcumin	18-28	tyrosine hydroxylase	Rattus norvegicus	118-120
29353037-0	2018	Curcumin protects cortical neurons against oxygen and glucose deprivation/reoxygenation injury through flotillin-1 and extracellular signal-regulated kinase1/2 pathway.	Curcumin	0-8	mitogen-activated protein kinase 3	Mus musculus	119-159
29456509-8	2018	Also, SOCS1 and SOCS3, negative regulators of STAT3 activity, were upregulated by curcumin treatment.	Curcumin	82-90	suppressor of cytokine signaling 3	Homo sapiens	16-21
29315967-7	2018	Curcumin also attenuated activities of Caspase-3, cyclooxygenase-2, inducible nitric oxide synthase, and levels of nuclear factor kappa-B, tumor necrosis factor-alpha, and interleukin-1beta, and cardiac tissue damages that were induced by DXR.	Curcumin	0-8	caspase 3	Rattus norvegicus	39-48
29315967-7	2018	Curcumin also attenuated activities of Caspase-3, cyclooxygenase-2, inducible nitric oxide synthase, and levels of nuclear factor kappa-B, tumor necrosis factor-alpha, and interleukin-1beta, and cardiac tissue damages that were induced by DXR.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	50-66
29880071-7	2018	Curcumin significantly attenuated liver injury and fibrosis, including amelioration of liver histological changes, reduction of hepatic enzymes, as well as decreased expression of liver fibrogenesis-associated variables, including Rac1, Rac1-GTP, NOX1, ERK1, HIF-1alpha and Sp1.	Curcumin	0-8	Rac family small GTPase 1	Rattus norvegicus	231-235
28731226-0	2018	Curcumin converts Foxp3+ regulatory T cells to T helper 1 cells in patients with lung cancer.	Curcumin	0-8	forkhead box P3	Homo sapiens	18-23
29351226-6	2018	Furthermore, curcumin pre-treatment significantly down-regulated the expression of TGF-beta1 and Smad3 mRNAs (both p &lt; 0.01), and up-regulated the expression of nuclear-factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both p &lt; 0.01) in the liver.	Curcumin	13-21	transforming growth factor, beta 1	Mus musculus	83-92
29351226-6	2018	Furthermore, curcumin pre-treatment significantly down-regulated the expression of TGF-beta1 and Smad3 mRNAs (both p &lt; 0.01), and up-regulated the expression of nuclear-factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both p &lt; 0.01) in the liver.	Curcumin	13-21	SMAD family member 3	Mus musculus	97-102
29351226-8	2018	Given these outcomes, curcumin could protect against CCl4-induced acute liver injury by inhibiting oxidative stress and inflammation, which may partly involve the activation of Nrf2/HO-1 and inhibition of TGF-beta1/Smad3 pathways.	Curcumin	22-30	transforming growth factor, beta 1	Mus musculus	205-214
29351226-8	2018	Given these outcomes, curcumin could protect against CCl4-induced acute liver injury by inhibiting oxidative stress and inflammation, which may partly involve the activation of Nrf2/HO-1 and inhibition of TGF-beta1/Smad3 pathways.	Curcumin	22-30	SMAD family member 3	Mus musculus	215-220
27937055-0	2017	Curcumin-loaded nanoliposomes linked to homing peptides for integrin targeting and neuropilin-1-mediated internalization.	Curcumin	0-8	neuropilin 1	Homo sapiens	83-95
27937055-3	2017	OBJECTIVES: This study encapsulates curcumin in nanoliposomes including an integrin-homing peptide combined with a C end R neuropilin-1 targeting motif for targeted delivery and receptor-mediated internalization, respectively.	Curcumin	36-44	neuropilin 1	Homo sapiens	123-135
29180881-7	2017	Further, curcumin and ACNU acted synergistically in their antitumor effects by targeting N-cadherin/MMP2/9, PI3K/AKT, and NF-kappaB/COX-2 signaling.	Curcumin	9-17	matrix metallopeptidase 2	Homo sapiens	100-106
29291086-0	2017	Curcumin improves glycolipid metabolism through regulating peroxisome proliferator activated receptor gamma signalling pathway in high-fat diet-induced obese mice and 3T3-L1 adipocytes.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	59-107
29291086-6	2017	In addition, curcumin stimulated lipolysis and improved glycolipid metabolism through upregulating the expressions of adipose triglyceride lipase and hormone-sensitive lipase, peroxisome proliferator activated receptor gamma/alpha (PPARgamma/alpha) and CCAAT/enhancer binding proteinalpha (C/EBPalpha) in adipose tissue of the mice.	Curcumin	13-21	peroxisome proliferator activated receptor gamma	Mus musculus	176-247
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	intercellular adhesion molecule 1	Mus musculus	147-180
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	intercellular adhesion molecule 1	Mus musculus	182-188
29291086-6	2017	In addition, curcumin stimulated lipolysis and improved glycolipid metabolism through upregulating the expressions of adipose triglyceride lipase and hormone-sensitive lipase, peroxisome proliferator activated receptor gamma/alpha (PPARgamma/alpha) and CCAAT/enhancer binding proteinalpha (C/EBPalpha) in adipose tissue of the mice.	Curcumin	13-21	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	253-288
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	intercellular adhesion molecule 1	Mus musculus	297-303
29291086-6	2017	In addition, curcumin stimulated lipolysis and improved glycolipid metabolism through upregulating the expressions of adipose triglyceride lipase and hormone-sensitive lipase, peroxisome proliferator activated receptor gamma/alpha (PPARgamma/alpha) and CCAAT/enhancer binding proteinalpha (C/EBPalpha) in adipose tissue of the mice.	Curcumin	13-21	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	290-300
29880071-7	2018	Curcumin significantly attenuated liver injury and fibrosis, including amelioration of liver histological changes, reduction of hepatic enzymes, as well as decreased expression of liver fibrogenesis-associated variables, including Rac1, Rac1-GTP, NOX1, ERK1, HIF-1alpha and Sp1.	Curcumin	0-8	Rac family small GTPase 1	Rattus norvegicus	237-241
29291086-7	2017	In differentiated 3T3-L1 cells, curcumin reduced glycerol release and increased glucose uptake via upregulating PPARgamma and C/EBPalpha.	Curcumin	32-40	peroxisome proliferator activated receptor gamma	Mus musculus	112-121
29291086-7	2017	In differentiated 3T3-L1 cells, curcumin reduced glycerol release and increased glucose uptake via upregulating PPARgamma and C/EBPalpha.	Curcumin	32-40	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	126-136
29880071-7	2018	Curcumin significantly attenuated liver injury and fibrosis, including amelioration of liver histological changes, reduction of hepatic enzymes, as well as decreased expression of liver fibrogenesis-associated variables, including Rac1, Rac1-GTP, NOX1, ERK1, HIF-1alpha and Sp1.	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	253-257
29880071-8	2018	Curcumin also attenuated leptin level and insulin resistance, which had increased in BDL rats (P&lt;0 05).	Curcumin	0-8	leptin	Rattus norvegicus	25-31
29880071-9	2018	Furthermore, compared with the BDL group, we observed an increase in IRS1 and a decrease in SOCS3 and STAT3 expression in the curcumin-treated BDL group (P&lt;0 05), indicating return of these parameters towards normalcy.	Curcumin	126-134	suppressor of cytokine signaling 3	Rattus norvegicus	92-97
29659146-0	2018	Curcumin accelerates cutaneous wound healing via multiple biological actions: The involvement of TNF-alpha, MMP-9, alpha-SMA, and collagen.	Curcumin	0-8	matrix metallopeptidase 9	Mus musculus	108-113
29659146-9	2018	Curcumin treatment significantly suppressed matrix metallopeptidase-9 and stimulated alpha smooth muscle levels in tumour necrosis factor alpha-treated fibroblasts via nuclear factor kappa B signalling.	Curcumin	0-8	matrix metallopeptidase 9	Mus musculus	44-69
28881302-9	2017	The curcumin loaded BSA:LMW-PDL nanoparticles were pretty stable over a period of 21days.	Curcumin	4-12	programmed cell death 1	Homo sapiens	28-31
30246573-0	2018	Bovine serum albumin nanoparticles improve the antitumour activity of curcumin in a murine melanoma model.	Curcumin	70-78	albumin	Mus musculus	7-20
28634058-8	2017	PFOS increased apoptotic gene expression but curcumin decreased the expression levels of caspase 3 and 8.	Curcumin	45-53	caspase 3	Rattus norvegicus	89-98
30057672-0	2018	Curcumin Effectively Rescued Parkinson"s Disease-Like Phenotypes in a Novel Drosophila melanogaster Model with dUCH Knockdown.	Curcumin	0-8	Ubiquitin carboxy-terminal hydrolase	Drosophila melanogaster	111-115
30057672-9	2018	In addition, dUCH knockdown flies treated with curcumin had improved locomotive abilities and less severe neurodegeneration.	Curcumin	47-55	Ubiquitin carboxy-terminal hydrolase	Drosophila melanogaster	13-17
29669267-1	2018	OBJECTIVE: The purpose of this study was to compare the effects of the oral administration of natural curcumin and a chemically modified curcumin (CMC2.24) on osteoclast-mediated bone resorption, apoptosis, and inflammation in a murine model of experimental periodontal disease.	Curcumin	137-145	COX assembly mitochondrial protein 2	Mus musculus	147-151
28962965-9	2017	Nano curcumin treatment also reduced the ERK1/2 phosphorylation levels in gp120-treated rat DRG.	Curcumin	5-13	mitogen activated protein kinase 3	Rattus norvegicus	41-47
28903060-1	2017	A series of 33 curcumin analogues was synthesized and tested on TRPA1, TRPM8, and TRPV1 channels.	Curcumin	15-23	transient receptor potential cation channel subfamily A member 1	Homo sapiens	64-69
28903060-1	2017	A series of 33 curcumin analogues was synthesized and tested on TRPA1, TRPM8, and TRPV1 channels.	Curcumin	15-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	82-87
29787434-9	2018	Curcumin also affected CCNG1 and PHPT1 transcriptional response counteracting some of the radiation induction.	Curcumin	0-8	cyclin G1	Homo sapiens	23-28
28731157-0	2017	Curcumin prevents lipopolysaccharide-induced matrix metalloproteinase-2 activity via the Ras/MEK1/2 signaling pathway in rat vascular smooth muscle cells.	Curcumin	0-8	matrix metallopeptidase 2	Rattus norvegicus	45-71
28731157-0	2017	Curcumin prevents lipopolysaccharide-induced matrix metalloproteinase-2 activity via the Ras/MEK1/2 signaling pathway in rat vascular smooth muscle cells.	Curcumin	0-8	mitogen activated protein kinase kinase 1	Rattus norvegicus	93-99
28731157-1	2017	The aim of the present study was to examine the effect of curcumin treatment on lipopolysaccharide (LPS)-induced matrix metalloproteinase-2 (MMP-2) activity, and assess whether the effects are mediated by the Ras/mitogen-activated protein kinase kinase 1/2 (MEK1/2) signaling pathway in vascular smooth muscle cells (VSMCs).	Curcumin	58-66	matrix metallopeptidase 2	Rattus norvegicus	113-139
28731157-1	2017	The aim of the present study was to examine the effect of curcumin treatment on lipopolysaccharide (LPS)-induced matrix metalloproteinase-2 (MMP-2) activity, and assess whether the effects are mediated by the Ras/mitogen-activated protein kinase kinase 1/2 (MEK1/2) signaling pathway in vascular smooth muscle cells (VSMCs).	Curcumin	58-66	matrix metallopeptidase 2	Rattus norvegicus	141-146
29777940-10	2018	The mRNA and protein expressions of caspase-3 exhibited substantial increases in OGD cells but these expressions were significantly decreased following curcumin supplementation.	Curcumin	152-160	caspase 3	Rattus norvegicus	36-45
28731157-1	2017	The aim of the present study was to examine the effect of curcumin treatment on lipopolysaccharide (LPS)-induced matrix metalloproteinase-2 (MMP-2) activity, and assess whether the effects are mediated by the Ras/mitogen-activated protein kinase kinase 1/2 (MEK1/2) signaling pathway in vascular smooth muscle cells (VSMCs).	Curcumin	58-66	mitogen activated protein kinase kinase 1	Rattus norvegicus	258-264
28731157-5	2017	Curcumin treatment was demonstrated to inhibit LPS-induced MMP-2 activity in rat VSMCs.	Curcumin	0-8	matrix metallopeptidase 2	Rattus norvegicus	59-64
28731157-7	2017	In addition, the results of the present study indicated that LPS-induced phosphorylation of Ras homolog family member A and MEK1/2 was significantly decreased by curcumin.	Curcumin	162-170	mitogen activated protein kinase kinase 1	Rattus norvegicus	124-130
28731157-9	2017	Taken together, these findings suggest that curcumin prevents of LPS-induced MMP-2 activity through Ras/MEK1/2 and NF-kappaB signaling.	Curcumin	44-52	matrix metallopeptidase 2	Rattus norvegicus	77-82
29902161-9	2018	Immunohistochemistry, immunofluorescence, and Western blot showed that curcumin treatment increased the expression of Beclin-1 and LC3-II, which were reduced by treatment with the autophagy inhibitor, 3-MA.	Curcumin	71-79	beclin 1	Rattus norvegicus	118-126
28731157-9	2017	Taken together, these findings suggest that curcumin prevents of LPS-induced MMP-2 activity through Ras/MEK1/2 and NF-kappaB signaling.	Curcumin	44-52	mitogen activated protein kinase kinase 1	Rattus norvegicus	104-110
29052798-6	2018	In addition, curcumin pretreatment markedly reduced the phosphorylation levels of Akt and Erk1/2.	Curcumin	13-21	mitogen activated protein kinase 3	Rattus norvegicus	90-96
28791384-11	2017	Furthermore, curcumin treatment decreased the expression of vascular cell adhesion molecule-1, intracellular adhesion molecule-1, monocyte chemoattractant protein-1 and tumor necrosis factor-alpha.	Curcumin	13-21	vascular cell adhesion molecule 1	Rattus norvegicus	60-128
29052798-7	2018	Taken together, our investigations demonstrated that curcumin pretreatment conferred BMSCs the ability to survive from H2O2-induced oxidative stress, which might attribute to its prevention of mitochondrial dysfunction and deactivation of Akt and Erk1/2 signaling pathways.	Curcumin	53-61	mitogen activated protein kinase 3	Rattus norvegicus	247-253
29664496-7	2018	2,6-Dimethyl-curcumin was more potent than curcumin in inhibiting NF-kappaB activity but less potent in inhibiting expression of cyclooxygenase-2 in LPS-activated RAW264.7 cells.	Curcumin	13-21	prostaglandin-endoperoxide synthase 2	Mus musculus	129-145
28849007-0	2017	Curcumin prevents reperfusion injury following ischemic stroke in rats via inhibition of NF-kappaB, ICAM-1, MMP-9 and caspase-3 expression.	Curcumin	0-8	caspase 3	Rattus norvegicus	118-127
28849007-8	2017	The findings revealed that inflammation (NF-kappaB, ICAM-1 and MMP-9) and apoptosis (caspase-3)-related markers were significantly downregulated in the curcumin-treated MCAO group compared with the vehicle-treated MCAO group.	Curcumin	152-160	caspase 3	Rattus norvegicus	85-94
29085504-6	2017	Suppression of miR-15a expression reversed the anticancer effect of curcumin on cell proliferation of human laryngeal cancer cells and increased Bcl-2 and PI3K/Akt protein expression in AMC-HN-8 cells treated with 40 microM of curcumin.	Curcumin	227-235	microRNA 15a	Homo sapiens	15-22
29085504-7	2017	The results of the present study suggest that curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a.	Curcumin	46-54	microRNA 15a	Homo sapiens	180-187
29518606-0	2018	Curcumin protects against hepatic stellate cells activation and migration by inhibiting the CXCL12/CXCR4 biological axis in liver fibrosis:A study in vitro and in vivo.	Curcumin	0-8	C-X-C motif chemokine ligand 12	Rattus norvegicus	92-98
28806703-0	2017	NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin.	Curcumin	153-161	NADPH oxidase 4	Homo sapiens	0-4
29518606-4	2018	Here, we investigated the contribution of curcumin on CXCL12/ CXCR4 biological axis in liver fibrosis.	Curcumin	42-50	C-X-C motif chemokine ligand 12	Rattus norvegicus	54-60
28806703-8	2017	Combined treatment with curcumin and thioridazine produced intracellular ROS in a NOX4-dependent manner, and ROS-mediated activation of Nrf2/ARE signaling played a critical role in the up-regulation of PSMA5 expression.	Curcumin	24-32	NADPH oxidase 4	Homo sapiens	82-86
29518606-6	2018	The alleviation of liver fibrosis with curcumin treatment was associated with a reduction of CXCL12, CXCR4, alpha-SMA and RhoA.	Curcumin	39-47	C-X-C motif chemokine ligand 12	Rattus norvegicus	93-99
28806703-10	2017	Therefore, we demonstrated that thioridazine plus curcumin induces proteasome activity by up-regulating PSMA5 expression via NOX4-mediated ROS production and that down-regulation of c-FLIP and Mcl-1 expression post-translationally is involved in apoptosis.	Curcumin	50-58	NADPH oxidase 4	Homo sapiens	125-129
29518606-8	2018	This study indicates that curcumin could protect against hepatic stellate cells activation and migration by inhibiting the CXCL12/CXCR4 biological axis in liver fibrosis.	Curcumin	26-34	C-X-C motif chemokine ligand 12	Rattus norvegicus	123-129
29621898-7	2018	Glutathione reductase (GR) activity and reduced glutathione levels increased in the case of peripheral blood mononuclear cells (PBMC) treated with curcumin, however, the trend was reversed with dimethoxycurcumin where, both glutathione reductase activity and reduced glutathione levels were significantly reduced.	Curcumin	147-155	glutathione-disulfide reductase	Homo sapiens	0-21
28668706-0	2017	Destructive effect of non-enzymatic glycation on catalase and remediation via curcumin.	Curcumin	78-86	catalase	Bos taurus	49-57
28668706-6	2017	However, in the presence of curcumin the amount of ROS was reduced resulting in increased activity of the glycated catalase.	Curcumin	28-36	catalase	Bos taurus	115-123
28668706-7	2017	The effect of high glucose level and the potential inhibitory effect of curcumin on aggregation and structural changes of catalase were also investigated.	Curcumin	72-80	catalase	Bos taurus	122-130
28668706-8	2017	Molecular dynamic simulations also showed that interaction of catalase with curcumin resulted in changes in accessible surface area (ASA) and pKa, two effective parameters of glycation, in potential glycation lysine residues.	Curcumin	76-84	catalase	Bos taurus	62-70
29621898-7	2018	Glutathione reductase (GR) activity and reduced glutathione levels increased in the case of peripheral blood mononuclear cells (PBMC) treated with curcumin, however, the trend was reversed with dimethoxycurcumin where, both glutathione reductase activity and reduced glutathione levels were significantly reduced.	Curcumin	147-155	glutathione-disulfide reductase	Homo sapiens	23-25
29621898-7	2018	Glutathione reductase (GR) activity and reduced glutathione levels increased in the case of peripheral blood mononuclear cells (PBMC) treated with curcumin, however, the trend was reversed with dimethoxycurcumin where, both glutathione reductase activity and reduced glutathione levels were significantly reduced.	Curcumin	147-155	glutathione-disulfide reductase	Homo sapiens	224-245
29621898-8	2018	RT-PCR analysis of glutathione reductase mRNA levels showed decrease in mRNA levels post treatment with dimethoxycurcumin (dimc) further corroborating GR enzyme assay results, however, we could not obtain significant result post curcumin treatment.	Curcumin	113-121	glutathione-disulfide reductase	Homo sapiens	19-40
28637240-9	2017	Herein, we show that compounds such as everolimus, ionomycin and curcumin, which directly or indirectly stimulate TFEB nuclear translocation, restore Tsc1-deficient NSPC migration.	Curcumin	65-73	transcription factor EB	Homo sapiens	114-118
29621898-8	2018	RT-PCR analysis of glutathione reductase mRNA levels showed decrease in mRNA levels post treatment with dimethoxycurcumin (dimc) further corroborating GR enzyme assay results, however, we could not obtain significant result post curcumin treatment.	Curcumin	113-121	glutathione-disulfide reductase	Homo sapiens	151-153
28927092-7	2017	The rate of apoptosis, caspase-3/caspase-8 activity and the expression of Bax were significantly increased, whereas Bcl-2 expression was significantly reduced following treatment with curcumin and/or FP, compared with the untreated control group.	Curcumin	184-192	caspase 8	Homo sapiens	33-42
28856444-7	2018	CONCLUSIONS: Curcumin-induced protection against ethanol damage involves endogenous PG, NO, gastrin and CGRP released from sensory nerves due to activation of the vanilloid TRPV1 receptor.	Curcumin	13-21	calcitonin-related polypeptide alpha	Rattus norvegicus	104-108
28927092-9	2017	Therefore, curcumin may enhance the anticancer effects of FP chemotherapy in MGC-803 cells through the promotion of apoptosis via the caspase-3/caspase-8, Bcl-2 and Bax signaling pathways.	Curcumin	11-19	caspase 8	Homo sapiens	144-153
28861154-5	2017	Besides, curcumin significantly decreased hemoglobin content and mRNA expression of CD31 and CD105 in tumor tissue, suggesting that curcumin could inhibit angiogenesis in NSCLC xenograft.	Curcumin	9-17	platelet and endothelial cell adhesion molecule 1	Homo sapiens	84-88
28861154-5	2017	Besides, curcumin significantly decreased hemoglobin content and mRNA expression of CD31 and CD105 in tumor tissue, suggesting that curcumin could inhibit angiogenesis in NSCLC xenograft.	Curcumin	132-140	platelet and endothelial cell adhesion molecule 1	Homo sapiens	84-88
29245915-4	2017	Sildenafil and curcumin reduced mTORC1 and mTORC2 activity and increased Beclin1 levels and the numbers of autophagosomes and autolysosomes in cells in a PERK-eIF2alpha-dependent fashion.	Curcumin	15-23	CREB regulated transcription coactivator 1	Mus musculus	32-38
28856444-7	2018	CONCLUSIONS: Curcumin-induced protection against ethanol damage involves endogenous PG, NO, gastrin and CGRP released from sensory nerves due to activation of the vanilloid TRPV1 receptor.	Curcumin	13-21	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	173-178
29245915-4	2017	Sildenafil and curcumin reduced mTORC1 and mTORC2 activity and increased Beclin1 levels and the numbers of autophagosomes and autolysosomes in cells in a PERK-eIF2alpha-dependent fashion.	Curcumin	15-23	CREB regulated transcription coactivator 2	Mus musculus	43-49
29245915-7	2017	Curcumin and sildenafil exposure reduced the expression of MCL-1, BCL-XL, thioredoxin and superoxide dismutase 2 (SOD2) in an eIF2alpha-dependent fashion.	Curcumin	0-8	superoxide dismutase 2	Homo sapiens	90-112
29245915-7	2017	Curcumin and sildenafil exposure reduced the expression of MCL-1, BCL-XL, thioredoxin and superoxide dismutase 2 (SOD2) in an eIF2alpha-dependent fashion.	Curcumin	0-8	superoxide dismutase 2	Homo sapiens	114-118
29277765-13	2018	DNA repair-related genes CCNH and XRCC5 were upregulated and LIG4 and PNKP downregulated by the combination of curcumin and irradiation compared with irradiation alone (p&lt;0.05).	Curcumin	111-119	cyclin H	Homo sapiens	25-29
29277765-13	2018	DNA repair-related genes CCNH and XRCC5 were upregulated and LIG4 and PNKP downregulated by the combination of curcumin and irradiation compared with irradiation alone (p&lt;0.05).	Curcumin	111-119	X-ray repair cross complementing 5	Homo sapiens	34-39
29277765-16	2018	Downregulation of LIG4 and PNKP and upregulation of XRCC5 and CCNH DNA-repair-related genes were involved in the radio-sensitizing efficacy of curcumin in colon cancer.	Curcumin	143-151	X-ray repair cross complementing 5	Homo sapiens	52-57
29277765-16	2018	Downregulation of LIG4 and PNKP and upregulation of XRCC5 and CCNH DNA-repair-related genes were involved in the radio-sensitizing efficacy of curcumin in colon cancer.	Curcumin	143-151	cyclin H	Homo sapiens	62-66
29191105-5	2018	Results from the quantitative structure active correlative analysis indicated that methoxy groups and beta-diketone structure possessing keto-enol tautomerism in curcumin were necessary to inhibit AhR transformation, and the addition of methyl and methoxy group(s) to the curcumin increased the inhibition effect.	Curcumin	162-170	aryl hydrocarbon receptor	Homo sapiens	197-200
29080451-0	2018	Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination.	Curcumin	0-8	RAD51 recombinase	Mus musculus	75-80
29080451-6	2018	In addition, curcumin decreased the expression of Rad51, which suggests curcumin induces DNA damage through regulating Rad51-dependant homologous recombination.	Curcumin	13-21	RAD51 recombinase	Mus musculus	50-55
29245915-8	2017	Curcumin and sildenafil interacted in a greater than additive fashion to increase the levels of reactive oxygen species; knock down of thioredoxin or SOD2 enhanced killing and over-expression of thioredoxin or SOD2 suppressed killing.	Curcumin	0-8	superoxide dismutase 2	Homo sapiens	210-214
29080451-6	2018	In addition, curcumin decreased the expression of Rad51, which suggests curcumin induces DNA damage through regulating Rad51-dependant homologous recombination.	Curcumin	13-21	RAD51 recombinase	Mus musculus	119-124
29191105-5	2018	Results from the quantitative structure active correlative analysis indicated that methoxy groups and beta-diketone structure possessing keto-enol tautomerism in curcumin were necessary to inhibit AhR transformation, and the addition of methyl and methoxy group(s) to the curcumin increased the inhibition effect.	Curcumin	272-280	aryl hydrocarbon receptor	Homo sapiens	197-200
29080451-6	2018	In addition, curcumin decreased the expression of Rad51, which suggests curcumin induces DNA damage through regulating Rad51-dependant homologous recombination.	Curcumin	72-80	RAD51 recombinase	Mus musculus	50-55
29080451-6	2018	In addition, curcumin decreased the expression of Rad51, which suggests curcumin induces DNA damage through regulating Rad51-dependant homologous recombination.	Curcumin	72-80	RAD51 recombinase	Mus musculus	119-124
29369461-0	2018	Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer.	Curcumin	24-32	aldo-keto reductase family 1 member C2	Homo sapiens	14-20
29080451-7	2018	Rad51-dependant homologous recombination is a vital DNA repair pathway for cancer cells to resist anti-tumoral DNA damage drugs, therefore, we studied the effect of curcumin on the sensitizing lymphoma cells to various chemotherapeutic drugs.	Curcumin	165-173	RAD51 recombinase	Mus musculus	0-5
29080451-9	2018	We also found curcumin sensitized CH12F3 lymphoma cells to DNA-PK and PARP inhibitors.	Curcumin	14-22	protein kinase, DNA activated, catalytic polypeptide	Mus musculus	59-65
29080451-11	2018	Taken together, these results demonstrate that curcumin induces DNA damage through regulating Rad51-dependant homologous recombination and triggers caspase3-dependent apoptosis, more importantly, curcumin sensitizes lymphoma cells to various DNA damage drugs.	Curcumin	47-55	RAD51 recombinase	Mus musculus	94-99
29975931-0	2018	Effects of Curcumin on Epidermal Growth Factor in Proliferative Vitreoretinopathy.	Curcumin	11-19	pro-epidermal growth factor	Oryctolagus cuniculus	23-46
28622711-11	2017	In vitro, curcumin could accelerate cell autophagy through regulating autophagy related Erk1/2 and Akt pathway, prevent cell apoptosis and promote expression of PMP22 and S100, and reduced deposition of Fibrin in cultured RSC96 SCs.	Curcumin	10-18	mitogen activated protein kinase 3	Rattus norvegicus	88-94
29369461-8	2018	After 1-month oral administration of curcumin, Aldo-Keto reductase 1C2 (AKR1C2) expression was elevated.	Curcumin	37-45	aldo-keto reductase family 1 member C2	Homo sapiens	47-70
29975931-4	2018	Curcumin regulates the biological functions of EGF, which plays important roles in the development of PVR.	Curcumin	0-8	pro-epidermal growth factor	Oryctolagus cuniculus	47-50
29975931-5	2018	This study aimed to evaluate the effect of curcumin on the regulation of EGF in PVR.	Curcumin	43-51	pro-epidermal growth factor	Oryctolagus cuniculus	73-76
29369461-8	2018	After 1-month oral administration of curcumin, Aldo-Keto reductase 1C2 (AKR1C2) expression was elevated.	Curcumin	37-45	aldo-keto reductase family 1 member C2	Homo sapiens	72-78
29975931-9	2018	Real-time PCR (RT-PCR) and western blot analysis were used to detect the concentrations of EGF mRNA and protein after treatment with curcumin.	Curcumin	133-141	pro-epidermal growth factor	Oryctolagus cuniculus	91-94
28431975-10	2017	The results showed that lower expressed miR-29b-1-5p decreased the IC50 of MCF-7/Adr cells and higher expressed miR-29b-1-5p, weaken the effects of liposomal curcumin to Adr-resistance.	Curcumin	158-166	microRNA 29b-1	Homo sapiens	40-49
28431975-10	2017	The results showed that lower expressed miR-29b-1-5p decreased the IC50 of MCF-7/Adr cells and higher expressed miR-29b-1-5p, weaken the effects of liposomal curcumin to Adr-resistance.	Curcumin	158-166	microRNA 29b-1	Homo sapiens	112-121
29975931-15	2018	Curcumin downregulated EGF expression in RPE cells, which also indicated time-effect and dose-effect relationships.	Curcumin	0-8	pro-epidermal growth factor	Oryctolagus cuniculus	23-26
29369461-10	2018	Meanwhile, curcumin treatments considerably increased the expression of AKR1C2 in prostate cancer cell lines, supporting the decrease of dihydrotestosterone.	Curcumin	11-19	aldo-keto reductase family 1 member C2	Homo sapiens	72-78
29975931-16	2018	The best curcumin concentration for the inhibition of EGF expression was 15 microg/mL.	Curcumin	9-17	pro-epidermal growth factor	Oryctolagus cuniculus	54-57
29975931-17	2018	RT-PCR and western blot analyses indicated that the EGF mRNA and expression of the protein in RPE cells treated with curcumin significantly decreased with time.	Curcumin	117-125	pro-epidermal growth factor	Oryctolagus cuniculus	52-55
29027056-8	2018	Curcumin supplementation prevented the LPS-induced upregulation in the protein activity of transcription factor NFkappaB, proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-1alpha), inducible nitric oxide synthase (iNOS) as well as the regulating molecules of the intrinsic apoptotic pathway (Bax, Bcl-2, Caspase 3 and Caspase 9) by ELISA.	Curcumin	0-8	caspase 3	Rattus norvegicus	309-318
29975931-20	2018	ELISA results showed that the EGF content in vitreous humor was higher in the control group than in the curcumin group.	Curcumin	104-112	pro-epidermal growth factor	Oryctolagus cuniculus	30-33
28509396-7	2017	Treatment with all concentrations of curcumin significantly improved total WBC, PLA2, TP, IgE, IL-4, IFN-gamma, IFN-gamma/IL-4 ratio, SOD, thiol, NO2 , and NO3 compared to S group (P &lt; 0.01 to P &lt; 0.001).	Curcumin	37-45	interleukin 4	Rattus norvegicus	95-99
29437881-5	2018	The P, E2 and SOD levels were higher, and the FSH, LH and MDA levels were significantly lower in the curcumin group than those in the d-gal group.	Curcumin	101-109	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	7-17
29542427-9	2018	Meanwhile, all individual biomarkers showed no, less or moderate inhibitory effect towards all the tested CYP450 except for curcumin that showed inhibition of CYP2C8 (91%), CYP2C9 (81%) and CYP2C19 (72%) at 10microM.	Curcumin	124-132	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	159-165
29542427-10	2018	CONCLUSION: Curcumin was found to be an active constituent that might contribute to the inhibition of SynacinnTM against CYP2C8, CYP2C9 and CYP2C19.	Curcumin	12-20	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	121-127
29437881-7	2018	In addition, curcumin treatment after d-gal administration resulted in significantly lower Sod2, Cat, 8-OhdG, 4-HNE, NTY and senescence-associated protein P16 expression levels, higher Amh expression levels and less apoptosis in granulosa cells than was observed in the d-gal group.	Curcumin	13-21	anti-Mullerian hormone	Mus musculus	185-188
29578162-9	2018	Results: Curcumin treatment up-regulated the activation of RAF/MEK/ERK at 4 h and 8 h after curcumin exposure in SUP-B15 cells, curcumin treatment induced autophagy at exactly 4 h and 8 h after curcumin exposure.	Curcumin	9-17	zinc fingers and homeoboxes 2	Homo sapiens	59-62
29578162-9	2018	Results: Curcumin treatment up-regulated the activation of RAF/MEK/ERK at 4 h and 8 h after curcumin exposure in SUP-B15 cells, curcumin treatment induced autophagy at exactly 4 h and 8 h after curcumin exposure.	Curcumin	92-100	zinc fingers and homeoboxes 2	Homo sapiens	59-62
29578162-9	2018	Results: Curcumin treatment up-regulated the activation of RAF/MEK/ERK at 4 h and 8 h after curcumin exposure in SUP-B15 cells, curcumin treatment induced autophagy at exactly 4 h and 8 h after curcumin exposure.	Curcumin	128-136	zinc fingers and homeoboxes 2	Homo sapiens	59-62
28509396-7	2017	Treatment with all concentrations of curcumin significantly improved total WBC, PLA2, TP, IgE, IL-4, IFN-gamma, IFN-gamma/IL-4 ratio, SOD, thiol, NO2 , and NO3 compared to S group (P &lt; 0.01 to P &lt; 0.001).	Curcumin	37-45	interleukin 4	Rattus norvegicus	122-126
28289922-10	2017	Significant inhibition in mRNA expression of iNOS, TGF-beta1 and TNF-alpha level was noted after curcumin treatment along with lowered MPO activity, inflammatory cell count, ROS, nitrite levels and collagen deposition in lungs.	Curcumin	97-105	transforming growth factor, beta 1	Mus musculus	51-60
29578162-9	2018	Results: Curcumin treatment up-regulated the activation of RAF/MEK/ERK at 4 h and 8 h after curcumin exposure in SUP-B15 cells, curcumin treatment induced autophagy at exactly 4 h and 8 h after curcumin exposure.	Curcumin	128-136	zinc fingers and homeoboxes 2	Homo sapiens	59-62
29438543-11	2018	Curcumin significantly increased (P &lt; 0.05) the expression of Nrf2, HO-1, and gamma-GCLc in the liver as compared to the CON diet.	Curcumin	0-8	heme oxygenase 1	Gallus gallus	71-75
29578162-11	2018	MEK specific inhibitor U0126 inhibited the occurrence of autophagy, and then blocked curcumin-induced cytotoxicity at 4 h and 8 h. Conclusions: Curcumin induce autophagic cell death in SUP-B15 cells via activating RAF/MEK/ERK pathway.	Curcumin	85-93	zinc fingers and homeoboxes 2	Homo sapiens	214-217
29578162-11	2018	MEK specific inhibitor U0126 inhibited the occurrence of autophagy, and then blocked curcumin-induced cytotoxicity at 4 h and 8 h. Conclusions: Curcumin induce autophagic cell death in SUP-B15 cells via activating RAF/MEK/ERK pathway.	Curcumin	144-152	zinc fingers and homeoboxes 2	Homo sapiens	214-217
29243061-9	2018	Curcumin in MCAO rats significantly improved brain damage and neurological function by upregulating p-Akt and p-mTOR and downregulating LC3-II/LC3-I, IL-1, TLR4, p-38, and p-p38.	Curcumin	0-8	mitogen activated protein kinase 14	Rattus norvegicus	162-166
29243061-9	2018	Curcumin in MCAO rats significantly improved brain damage and neurological function by upregulating p-Akt and p-mTOR and downregulating LC3-II/LC3-I, IL-1, TLR4, p-38, and p-p38.	Curcumin	0-8	mitogen activated protein kinase 14	Rattus norvegicus	174-177
29243061-11	2018	Curcumin exerts neuroprotective effects by attenuating autophagic activities through mediating the PI3K/Akt/mTOR pathway, while also suppressing an inflammatory reaction by regulating the TLR4/p38/MAPK pathway.	Curcumin	0-8	mitogen activated protein kinase 14	Rattus norvegicus	193-196
28605812-11	2017	Similarly, curcumin also inhibited TGFbeta1-induced Smad3 phosphorylation, Nox4-derived H2O2 production, and total collagen synthesis by conjunctival fibroblasts (P &lt; 0.05; n = 4-6).	Curcumin	11-19	mothers against decapentaplegic homolog 3	Oryctolagus cuniculus	52-57
28402926-0	2017	Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down-regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells.	Curcumin	0-8	C-X-C motif chemokine ligand 12	Homo sapiens	109-114
27957686-3	2018	Pretreatment with curcumin at 5, 10, and 20 muM for 2 h prior to colistin (200 muM) exposure for 24 h, produced an anti-inflammatory effect by significantly down-regulating the expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2), phosphorylation of the inhibitor of nuclear factor-kappa B (NF-kappaB) (p-IkappaB)-alpha, and concomitantly NF-kappaB levels.	Curcumin	18-26	prostaglandin-endoperoxide synthase 2	Mus musculus	222-238
29765996-4	2018	Cyclin D1 is overexpressed in ESCC and curcumin may change its expression.	Curcumin	39-47	cyclin D1	Homo sapiens	0-9
27957686-3	2018	Pretreatment with curcumin at 5, 10, and 20 muM for 2 h prior to colistin (200 muM) exposure for 24 h, produced an anti-inflammatory effect by significantly down-regulating the expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2), phosphorylation of the inhibitor of nuclear factor-kappa B (NF-kappaB) (p-IkappaB)-alpha, and concomitantly NF-kappaB levels.	Curcumin	18-26	prostaglandin-endoperoxide synthase 2	Mus musculus	240-245
29451216-10	2018	Curcumin and EGCG alone or in combination increased axonal sprouting, decreased glial scar formation, and altered the levels of macrophage inflammatory protein 1-alpha, interleukin-1beta, interleukin-4 and interleukin-6 cytokines.	Curcumin	0-8	C-C motif chemokine ligand 3	Rattus norvegicus	128-167
29451216-10	2018	Curcumin and EGCG alone or in combination increased axonal sprouting, decreased glial scar formation, and altered the levels of macrophage inflammatory protein 1-alpha, interleukin-1beta, interleukin-4 and interleukin-6 cytokines.	Curcumin	0-8	interleukin 4	Rattus norvegicus	188-201
29285138-7	2017	Moreover, the results of immunohistochemical analysis indicated that the expression levels of histone deacetylase 1 (HDAC1), matrix metalloproteinase-2 (MMP-2) and transforming growth factor beta (TGFbeta) decreased in the curcumin treatment group, compared with the non-treated group or the negative control group.	Curcumin	223-231	histone deacetylase 1	Rattus norvegicus	94-115
29285138-7	2017	Moreover, the results of immunohistochemical analysis indicated that the expression levels of histone deacetylase 1 (HDAC1), matrix metalloproteinase-2 (MMP-2) and transforming growth factor beta (TGFbeta) decreased in the curcumin treatment group, compared with the non-treated group or the negative control group.	Curcumin	223-231	histone deacetylase 1	Rattus norvegicus	117-122
29285138-7	2017	Moreover, the results of immunohistochemical analysis indicated that the expression levels of histone deacetylase 1 (HDAC1), matrix metalloproteinase-2 (MMP-2) and transforming growth factor beta (TGFbeta) decreased in the curcumin treatment group, compared with the non-treated group or the negative control group.	Curcumin	223-231	matrix metallopeptidase 2	Rattus norvegicus	125-151
29285138-7	2017	Moreover, the results of immunohistochemical analysis indicated that the expression levels of histone deacetylase 1 (HDAC1), matrix metalloproteinase-2 (MMP-2) and transforming growth factor beta (TGFbeta) decreased in the curcumin treatment group, compared with the non-treated group or the negative control group.	Curcumin	223-231	matrix metallopeptidase 2	Rattus norvegicus	153-158
29285138-9	2017	Furthermore, chromatin immunoprecipitation results suggested that curcumin was capable of promoting the transcription activation of TIMP1 through suppressing HDAC1 expression and increasing histone H3 acetylation at the TIMP1 promoter region in SHRs.	Curcumin	66-74	histone deacetylase 1	Rattus norvegicus	158-163
28402926-7	2017	Curcumin significantly up-regulated the expression of Slit-2 in Ishikawa, Hec-1B and primary endometrial cancer cells while it down-regulated the expression of stromal cell-derived factor-1 (SDF-1) and CXCR4 which in turn, suppressed the expression of matrix metallopeptidases (MMP) 2 and 9, thus attenuating the migration of endometrial cancer cells.	Curcumin	0-8	C-X-C motif chemokine ligand 12	Homo sapiens	160-189
28402926-7	2017	Curcumin significantly up-regulated the expression of Slit-2 in Ishikawa, Hec-1B and primary endometrial cancer cells while it down-regulated the expression of stromal cell-derived factor-1 (SDF-1) and CXCR4 which in turn, suppressed the expression of matrix metallopeptidases (MMP) 2 and 9, thus attenuating the migration of endometrial cancer cells.	Curcumin	0-8	C-X-C motif chemokine ligand 12	Homo sapiens	191-196
28402926-7	2017	Curcumin significantly up-regulated the expression of Slit-2 in Ishikawa, Hec-1B and primary endometrial cancer cells while it down-regulated the expression of stromal cell-derived factor-1 (SDF-1) and CXCR4 which in turn, suppressed the expression of matrix metallopeptidases (MMP) 2 and 9, thus attenuating the migration of endometrial cancer cells.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	252-290
28402926-8	2017	In summary, we have demonstrated that curcumin has inhibitory effect on cellular migration via Slit-2 mediated down-regulation of CXCR4, SDF-1, and MMP2/MMP9 in endometrial carcinoma cells.	Curcumin	38-46	C-X-C motif chemokine ligand 12	Homo sapiens	137-142
28402926-8	2017	In summary, we have demonstrated that curcumin has inhibitory effect on cellular migration via Slit-2 mediated down-regulation of CXCR4, SDF-1, and MMP2/MMP9 in endometrial carcinoma cells.	Curcumin	38-46	matrix metallopeptidase 2	Homo sapiens	148-152
28365185-0	2017	Curcumin and its cyclohexanone analogue inhibited human Equilibrative nucleoside transporter 1 (ENT1) in pancreatic cancer cells.	Curcumin	0-8	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	56-94
29225578-0	2017	Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/beta-Catenin Pathways via miR-130a.	Curcumin	0-8	microRNA 130a	Homo sapiens	95-103
29765996-7	2018	Results: Nano-curcumin increased cell cytotoxicity, decreased IC50, and down-regulated of cyclin D1.	Curcumin	14-22	cyclin D1	Homo sapiens	90-99
29225578-9	2017	MiR-130a was down-regulated by curcumin treatment, and overexpressing miR-130a could abolish the anti-tumor activity of curcumin.	Curcumin	31-39	microRNA 130a	Homo sapiens	0-8
28365185-0	2017	Curcumin and its cyclohexanone analogue inhibited human Equilibrative nucleoside transporter 1 (ENT1) in pancreatic cancer cells.	Curcumin	0-8	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	96-100
29765996-9	2018	Conclusion: Nano-curcumin suppressed proliferation of KYSE-30 cells and expression of cyclin D1 although its use in combination with other chemotherapeutic agents requires further testing.	Curcumin	17-25	cyclin D1	Homo sapiens	86-95
28365185-3	2017	As curcumin is a promiscuous transporter inhibitor; we suspected that increased resistance occurred via inhibition of Equilibrative nucleoside transporter 1 (ENT1)-mediated gemcitabine uptake.	Curcumin	3-11	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	118-156
29225578-9	2017	MiR-130a was down-regulated by curcumin treatment, and overexpressing miR-130a could abolish the anti-tumor activity of curcumin.	Curcumin	120-128	microRNA 130a	Homo sapiens	0-8
29225578-9	2017	MiR-130a was down-regulated by curcumin treatment, and overexpressing miR-130a could abolish the anti-tumor activity of curcumin.	Curcumin	120-128	microRNA 130a	Homo sapiens	70-78
28365185-3	2017	As curcumin is a promiscuous transporter inhibitor; we suspected that increased resistance occurred via inhibition of Equilibrative nucleoside transporter 1 (ENT1)-mediated gemcitabine uptake.	Curcumin	3-11	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	158-162
29225578-10	2017	Our study confirms that curcumin is able to inhibit colon cancer by suppressing the Wnt/beta-catenin pathways via miR-130a.	Curcumin	24-32	microRNA 130a	Homo sapiens	114-122
28365185-6	2017	We found that curcumin and A13 concentration-dependently inhibited the ENT1-mediated accumulation of both uridine and gemcitabine in MIA PaCa-2 and PANC-1 cells.	Curcumin	14-22	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	71-75
29139094-13	2018	CONCLUSION: Curcumin might have therapeutic potential in breast cancer through regulating breast cancer-related genes, including SERPINE1, PGAP3, MAP3K1, MAPK1, GSTO2, VIM, SPARC, and FGF2.	Curcumin	12-20	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	146-152
28365185-10	2017	From these results, we concluded that curcumin and A13 are inhibitors of the ENT1 transporter, but only at high concentrations (2-20microM).	Curcumin	38-46	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	77-81
28365185-11	2017	Curcumin is unlikely to inhibit gemcitabine uptake in tumours but may interfere with the oral absorption of ENT1 substrates due to high gut concentrations readily achievable from over-the-counter tablets/capsules.	Curcumin	0-8	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	108-112
29225578-11	2017	MiR-130a may serve as a new target of curcumin for CRC treatment.	Curcumin	38-46	microRNA 130a	Homo sapiens	0-8
29312546-0	2017	Curcumin downregulates the expression of Snail via suppressing Smad2 pathway to inhibit TGF-beta1-induced epithelial-mesenchymal transitions in hepatoma cells.	Curcumin	0-8	SMAD family member 2	Homo sapiens	63-68
29312546-7	2017	Furthermore, we demonstrated that curcumin inhibited TGF-beta1-induced EMT via inhibiting Smad2 phosphorylation and nuclear translocation, then suppressing Smad2 combined with the promoter of Snail which inhibited the transcriptional expression of Snail.	Curcumin	34-42	SMAD family member 2	Homo sapiens	90-95
28485773-4	2017	In a dorsal root ganglion (DRG) culture, curcumin effectively inhibited TNF-alpha-induced neuroinflammation, in a dose-dependent manner, as shown by mRNA and protein expression of IL-6 and COX-2.	Curcumin	41-49	cytochrome c oxidase II, mitochondrial	Mus musculus	189-194
29312546-7	2017	Furthermore, we demonstrated that curcumin inhibited TGF-beta1-induced EMT via inhibiting Smad2 phosphorylation and nuclear translocation, then suppressing Smad2 combined with the promoter of Snail which inhibited the transcriptional expression of Snail.	Curcumin	34-42	SMAD family member 2	Homo sapiens	156-161
29291086-8	2017	We concluded that curcumin has the potential to improve glycolipid metabolism disorders caused by obesity through regulating PPARgamma signalling pathway.	Curcumin	18-26	peroxisome proliferator activated receptor gamma	Mus musculus	125-134
29405636-0	2018	Dietary Curcumin Intervention Targets Mouse White Adipose Tissue Inflammation and Brown Adipose Tissue UCP1 Expression.	Curcumin	8-16	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	103-107
29048630-6	2017	Expression levels of TGF-alpha and TGFbeta1 genes were upregulated in MCF-10F and downregulated in Tumor2 cell lines treated with curcumin.	Curcumin	130-138	transforming growth factor alpha	Homo sapiens	21-30
28881600-0	2017	Curcumin induces G2/M cell cycle arrest and apoptosis of head and neck squamous cell carcinoma in vitro and in vivo through ATM/Chk2/p53-dependent pathway.	Curcumin	0-8	checkpoint kinase 2	Homo sapiens	128-132
29405636-9	2018	Finally, the in vivo and in vitro investigations suggested that curcumin increased expression of uncoupling protein 1 (UCP1), possibly involving PPAR-dependent and -independent mechanisms.	Curcumin	64-72	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	97-117
28336111-6	2017	Moreover, the increase in the expression of Rac1, Rac1-GTP, and NOX1 observed in BDL rats was precluded and reversed back toward normalcy by curcumin treatment (P &lt; 0.05).	Curcumin	141-149	Rac family small GTPase 1	Rattus norvegicus	44-48
28336111-6	2017	Moreover, the increase in the expression of Rac1, Rac1-GTP, and NOX1 observed in BDL rats was precluded and reversed back toward normalcy by curcumin treatment (P &lt; 0.05).	Curcumin	141-149	Rac family small GTPase 1	Rattus norvegicus	50-54
29078859-0	2017	Corrigendum to "Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down-regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells" [J Nutr Biochem 44 (2017) 60-70].	Curcumin	16-24	C-X-C motif chemokine ligand 12	Homo sapiens	125-130
29405636-9	2018	Finally, the in vivo and in vitro investigations suggested that curcumin increased expression of uncoupling protein 1 (UCP1), possibly involving PPAR-dependent and -independent mechanisms.	Curcumin	64-72	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	119-123
28901458-0	2017	Neuroprotective effects of curcumin alleviate lumbar intervertebral disc degeneration through regulating the expression of iNOS, COX-2, TGF-beta1/2, MMP-9 and BDNF in a rat model.	Curcumin	27-35	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	129-134
28901458-3	2017	The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, transforming growth factor (TGF)-beta1/2, matrix metalloproteinase (MMP)-9 and brain-derived neurotrophic factor (BDNF) in a rat model of LIDD.	Curcumin	56-64	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	161-183
28336111-8	2017	CONCLUSIONS: Curcumin attenuated liver damage through the downregulation of Rac1, Rac1-GTP, and NOX1 as well as reduced oxidative stress in the serum and liver tissue of BDL rats.	Curcumin	13-21	Rac family small GTPase 1	Rattus norvegicus	76-80
28336111-8	2017	CONCLUSIONS: Curcumin attenuated liver damage through the downregulation of Rac1, Rac1-GTP, and NOX1 as well as reduced oxidative stress in the serum and liver tissue of BDL rats.	Curcumin	13-21	Rac family small GTPase 1	Rattus norvegicus	82-86
28350049-6	2017	We provide evidence that curcumin upregulates the expression of CRABPII, RARbeta and RARgamma in two different TNBC cell lines.	Curcumin	25-33	retinoic acid receptor gamma	Homo sapiens	85-93
28901458-5	2017	It was revealed that treatment with curcumin significantly reduced interleukin (IL)-1beta and IL-6, iNOS, COX-2 and MMP-9 levels in rats with LIDD.	Curcumin	36-44	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	106-111
29405636-10	2018	CONCLUSIONS: Curcumin intervention targets both WAT inflammation and BAT UCP1 expression.	Curcumin	13-21	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	73-77
29353037-4	2018	Based on these findings, we concluded that curcumin could confer neuroprotection against OGD/R injury through a novel flotillin-1 and ERK1/2 pathway.	Curcumin	43-51	mitogen-activated protein kinase 3	Mus musculus	134-140
29401702-4	2018	DHA and curcumin induce the expression of LCE3A/LCE3D/LCE3E mRNAs at concentrations corresponding to their affinity for VDR.	Curcumin	8-16	late cornified envelope 3A	Homo sapiens	42-47
28905625-0	2017	Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of Depression.	Curcumin	49-57	solute carrier family 18 member A2	Homo sapiens	103-109
28198062-8	2017	We further illustrated that curcumin efficiently abolished lung CSC traits, as evidenced by reduced tumorsphere formation, reduced number of CD133-positive cells, decreased expression levels of lung CSC markers, as well as proliferation inhibition and apoptosis induction.	Curcumin	28-36	prominin 1	Homo sapiens	141-146
28198625-4	2017	According to the histopathological examination of liver tissues and biomarker detection in serum and livers, it was demonstrated that curcumin attenuated DEN-induced hepatocarcinogenesis through parts of regulating the oxidant stress enzymes (T-SOD and CAT), liver function (ALT and AST) and LDHA, AFP level, and COX-2/PGE2 pathway.	Curcumin	134-142	lactate dehydrogenase A	Mus musculus	292-296
28198625-4	2017	According to the histopathological examination of liver tissues and biomarker detection in serum and livers, it was demonstrated that curcumin attenuated DEN-induced hepatocarcinogenesis through parts of regulating the oxidant stress enzymes (T-SOD and CAT), liver function (ALT and AST) and LDHA, AFP level, and COX-2/PGE2 pathway.	Curcumin	134-142	cytochrome c oxidase II, mitochondrial	Mus musculus	313-318
28887914-2	2017	Immunosuppressive therapy for IPEX patients has been generally ineffective and has caused severe side effects, however curcumin has shown immune regulation properties for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel diseases without side effects.	Curcumin	119-127	forkhead box P3	Homo sapiens	30-34
28887914-3	2017	OBJECTIVE: The aim of this study was to investigate whether curcumin would attenuate symptoms of IPEX in mouse model and would prolong its survival period.	Curcumin	60-68	forkhead box P3	Homo sapiens	97-101
28198625-5	2017	Furthermore, curcumin attenuated metabolic disorders via increasing concentration of glucose and fructose, and decreasing levels of glycine and proline, and mRNA expression of GLUT1, PKM and FASN.	Curcumin	13-21	pyruvate kinase, muscle	Mus musculus	183-186
28198625-6	2017	Docking study indicated that curcumin presented strong affinity with key metabolism enzymes such as GLUT1, PKM, FASN and LDHA.	Curcumin	29-37	pyruvate kinase, muscle	Mus musculus	107-110
28905939-6	2018	Curcumin administration significantly suppressed the deposition of type I and type III collagens in the heart tissues of diabetic rats, accompanied by markedly reduced TGF-beta1 production, suppressed TbetaR II levels and Smad2/3 phosphorylation, and increased Smad7 expression.	Curcumin	0-8	transforming growth factor, beta receptor 2	Rattus norvegicus	201-210
28198625-6	2017	Docking study indicated that curcumin presented strong affinity with key metabolism enzymes such as GLUT1, PKM, FASN and LDHA.	Curcumin	29-37	lactate dehydrogenase A	Mus musculus	121-125
28905939-9	2018	Application of curcumin (25 mumol/L) inhibited TGF-beta1- or HG-induced AMPK/p38 MAPK activation and suppressed collagen synthesis in the fibroblasts.	Curcumin	15-23	mitogen activated protein kinase 14	Rattus norvegicus	77-80
28905939-11	2018	Our results demonstrate that curcumin suppresses diabetes-associated collagen synthesis in rat myocardium not only by inhibiting TGF-beta1 production and canonical Smad signaling but also by blocking the non-canonical AMPK/p38 MAPK pathway.	Curcumin	29-37	mitogen activated protein kinase 14	Rattus norvegicus	223-226
29479379-5	2018	IL-6, tumor necrosis factor (TNF)-alpha, and intercellular adhesion molecule (ICAM)-1 concentrations were lower in curcumin pretreated animals when compared to control animals.	Curcumin	115-123	interleukin 6	Sus scrofa	0-4
28231299-5	2017	Therefore, we suggest miR-34a-5p/miR-34c-5p/miR-302b-3p -LEF1-CCND1/WNT1/MYC axis may be a crucial mechanism in inhibition of lung cancer metastasis by curcumin.	Curcumin	152-160	microRNA 34a	Homo sapiens	22-29
28231299-5	2017	Therefore, we suggest miR-34a-5p/miR-34c-5p/miR-302b-3p -LEF1-CCND1/WNT1/MYC axis may be a crucial mechanism in inhibition of lung cancer metastasis by curcumin.	Curcumin	152-160	lymphoid enhancer binding factor 1	Homo sapiens	57-61
28231299-5	2017	Therefore, we suggest miR-34a-5p/miR-34c-5p/miR-302b-3p -LEF1-CCND1/WNT1/MYC axis may be a crucial mechanism in inhibition of lung cancer metastasis by curcumin.	Curcumin	152-160	cyclin D1	Homo sapiens	62-67
29479379-5	2018	IL-6, tumor necrosis factor (TNF)-alpha, and intercellular adhesion molecule (ICAM)-1 concentrations were lower in curcumin pretreated animals when compared to control animals.	Curcumin	115-123	tumor necrosis factor	Sus scrofa	6-39
28237485-0	2017	Effect of curcumin on expressions of NF-kappaBp65, TNF-alpha and IL-8 in placental tissue of premature birth of infected mice.	Curcumin	10-18	chemokine (C-X-C motif) ligand 15	Mus musculus	65-69
28237485-1	2017	OBJECTIVE: To observe the effect of curcumin on expressions of nuclear transcription factor-kappa Bp65 (NF-kappaBp65), TNF-alpha and IL-8 in placental tissue of premature birth of infected mice induced by lipopolysaccharide (LPS).	Curcumin	36-44	chemokine (C-X-C motif) ligand 15	Mus musculus	133-137
29034440-9	2018	Furthermore, curcumin repressed the capacity of risperidone to induce the hepatic over expression of enzymes involved in lipid metabolism (LXRalpha, FAS, ACC1, LPL, PPARgamma, ACO, SREBP2) and decreased risperidone-induced glucose intolerance and hypertriglyceridemia.	Curcumin	13-21	peroxisome proliferator activated receptor gamma	Mus musculus	165-174
28237485-10	2017	CONCLUSIONS: Curcumin can effectively prevent the active pathway of NF-kappaB in pregnant tissue of premature birth of infected mice, reduce the expression of TNF-alpha and IL-8 and relieve the damage of lipid peroxide of oxidative stress of LPS on mother-fetus and further to achieve the objective of preventing and curing premature birth induced with infection.	Curcumin	13-21	chemokine (C-X-C motif) ligand 15	Mus musculus	173-177
29351226-0	2018	Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Modulation of the Nrf2/HO-1 and TGF-beta1/Smad3 Pathway.	Curcumin	0-8	transforming growth factor, beta 1	Mus musculus	115-124
29351226-0	2018	Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Modulation of the Nrf2/HO-1 and TGF-beta1/Smad3 Pathway.	Curcumin	0-8	SMAD family member 3	Mus musculus	125-130
27995523-0	2017	In Vitro Modulation of TrkB Receptor Signaling upon Sequential Delivery of Curcumin-DHA Loaded Carriers Towards Promoting Neuronal Survival.	Curcumin	75-83	neurotrophic receptor tyrosine kinase 2	Homo sapiens	23-27
29351226-4	2018	Curcumin pre-treatment at 50, 100 and 200 mg/kg significantly ameliorated CCl4-induced oxidative stress, characterized by decreased malondialdehyde (MDA) formations, and increased superoxide dismutase (SOD), catalase (CAT) activities and glutathione (GSH) content, followed by a decrease in caspase-9 and -3 activities.	Curcumin	0-8	caspase 9	Mus musculus	291-307
30149755-8	2018	We found that, for the first time, curcumin directly downregulates a tumor-promoting microRNA (miRNA), miR-7641, in bladder cancer, which has tumor-promoting characteristics.	Curcumin	35-43	MLX interacting protein	Homo sapiens	95-98
30149755-9	2018	Curcumin induces the downregulation of miR-7641 and subsequent upregulation of p16 which is a target of miR-7641 at the post-transcriptional level, which leads to the decreased invasion and increased apoptosis of bladder cancer cells.	Curcumin	0-8	MLX interacting protein	Homo sapiens	39-42
28102847-0	2017	Curcumin represses mouse 3T3-L1 cell adipogenic differentiation via inhibiting miR-17-5p and stimulating the Wnt signalling pathway effector Tcf7l2.	Curcumin	0-8	transcription factor 7 like 2, T cell specific, HMG box	Mus musculus	141-147
30149755-9	2018	Curcumin induces the downregulation of miR-7641 and subsequent upregulation of p16 which is a target of miR-7641 at the post-transcriptional level, which leads to the decreased invasion and increased apoptosis of bladder cancer cells.	Curcumin	0-8	MLX interacting protein	Homo sapiens	104-107
28102847-8	2017	We observed that curcumin attenuated miR-17-5p expression and stimulated Tcf7l2 expression in 3T3-L1 cells.	Curcumin	17-25	transcription factor 7 like 2, T cell specific, HMG box	Mus musculus	73-79
29127008-6	2018	In this study, curcumin mimicked or altered the binding pattern of anti-IL-2 Abs against IL-2 and remarkably inhibited the interaction of recombinant IL-2 with the IL-2 receptor alpha, CD25.	Curcumin	15-23	interleukin 2 receptor subunit alpha	Homo sapiens	164-183
28056970-6	2017	In vitro experiments demonstrated that curcumin treatment could reverse the up-regulation of active forms of caspase-3 and caspase-8, and down-regulation of bcl-2 induced by alcohol treatment.	Curcumin	39-47	caspase 8	Homo sapiens	123-132
29127008-6	2018	In this study, curcumin mimicked or altered the binding pattern of anti-IL-2 Abs against IL-2 and remarkably inhibited the interaction of recombinant IL-2 with the IL-2 receptor alpha, CD25.	Curcumin	15-23	interleukin 2 receptor subunit alpha	Homo sapiens	185-189
29172709-6	2018	The miR-770-5p and miR-1247 expression levels in the DLK1-DIO3 imprinted gene cluster were significantly different between the curcumin-treated and control HuPCaSCs.	Curcumin	127-135	microRNA 7705	Homo sapiens	4-14
27894665-8	2017	Curcumin supplementation inhibited FasL mRNA production and up-regulated the expression of pro-apoptotic molecules granzyme A (at the mRNA level) and granulysin (at the protein level), suggesting degranulation of granulysin-bearing cells following curcumin supplementation.	Curcumin	0-8	granzyme A	Homo sapiens	115-125
29115530-11	2018	In addition, curcumin administration led to a downregulation in the expression of lipogenic genes, including sterol regulatory element-binding protein, fatty acid synthase and acetyl-CoA carboxylase (P&lt;0.05).	Curcumin	13-21	fatty acid synthase	Rattus norvegicus	152-171
27894665-8	2017	Curcumin supplementation inhibited FasL mRNA production and up-regulated the expression of pro-apoptotic molecules granzyme A (at the mRNA level) and granulysin (at the protein level), suggesting degranulation of granulysin-bearing cells following curcumin supplementation.	Curcumin	0-8	granulysin	Homo sapiens	150-160
27894665-8	2017	Curcumin supplementation inhibited FasL mRNA production and up-regulated the expression of pro-apoptotic molecules granzyme A (at the mRNA level) and granulysin (at the protein level), suggesting degranulation of granulysin-bearing cells following curcumin supplementation.	Curcumin	0-8	granulysin	Homo sapiens	213-223
27894665-10	2017	The present results suggest that curcumin supplementation increases cytotoxicity-related molecules granzyme A and granulysin in patients with HAM/TSP.	Curcumin	33-41	granzyme A	Homo sapiens	99-109
27894665-10	2017	The present results suggest that curcumin supplementation increases cytotoxicity-related molecules granzyme A and granulysin in patients with HAM/TSP.	Curcumin	33-41	granulysin	Homo sapiens	114-124
28291961-0	2017	Attenuation of Oxidative Stress-Induced Osteoblast Apoptosis by Curcumin is Associated with Preservation of Mitochondrial Functions and Increased Akt-GSK3beta Signaling.	Curcumin	64-72	glycogen synthase kinase 3 beta	Homo sapiens	150-158
28291961-13	2017	Furthermore, curcumin treatment markedly increased levels of phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3beta (GSK3beta).	Curcumin	13-21	glycogen synthase kinase 3 beta	Homo sapiens	118-148
28291961-13	2017	Furthermore, curcumin treatment markedly increased levels of phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3beta (GSK3beta).	Curcumin	13-21	glycogen synthase kinase 3 beta	Homo sapiens	150-158
29073609-6	2018	Both nano-curcumin and curcumin induced changes in proteasome-mediated proteolytic activity characterized by increased activity of the proteasome subunits beta2 and beta5i/beta1 and reduced activity of beta5/beta1i.	Curcumin	10-18	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	155-160
28291961-14	2017	CONCLUSION: Curcumin administration ameliorates oxidative stress-induced apoptosis in osteoblasts by preserving mitochondrial functions and activation of Akt-GSK3beta signaling.	Curcumin	12-20	glycogen synthase kinase 3 beta	Homo sapiens	158-166
29069652-11	2017	CONCLUSION: This study suggests that curcumin could protect against oxidative stress-induced injury in PD rats via the Wnt/beta-catenin signaling pathway.	Curcumin	37-45	Wnt family member 3A	Rattus norvegicus	119-122
27592626-0	2017	Curcumin Suppresses Tumor Growth and Angiogenesis in Human Glioma Cells Through Modulation of Vascular Endothelial Growth Factor/ Angiopoietin-2/Thrombospondin-1 Signaling.	Curcumin	0-8	angiopoietin 2	Homo sapiens	130-144
27592626-8	2017	Expression of VEGF and Ang-2 was inhibited by curcumin, whereas TSP-1 expression was up-regulated.	Curcumin	46-54	angiopoietin 2	Homo sapiens	23-28
27592626-9	2017	CONCLUSION: This study shows that curcumin inhibits tumor growth by inhibiting VEGF/Ang-2/TSP-1- mediated angiogenesis in a xenograft glioma mouse model.	Curcumin	34-42	angiopoietin 2	Homo sapiens	84-89
29036814-0	2017	Curcumin Ameliorates Neuroinflammation, Neurodegeneration, and Memory Deficits in p25 Transgenic Mouse Model that Bears Hallmarks of Alzheimer"s Disease.	Curcumin	0-8	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	82-85
29036814-6	2017	In this study, we aimed to understand the effects of early intervention with a potent natural anti-inflammatory agent, curcumin, on p25-mediated neuroinflammation and the progression of neurodegeneration in p25Tg mice.	Curcumin	119-127	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	132-135
29036814-7	2017	The results from this study showed that curcumin effectively counteracted the p25-mediated glial activation and pro-inflammatory chemokines/cytokines production in p25Tg mice.	Curcumin	40-48	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	78-81
29036814-8	2017	Moreover, this curcumin-mediated suppression of neuroinflammation reduced the progression of p25-induced tau/amyloid pathology and in turn ameliorated the p25-induced cognitive impairments.	Curcumin	15-23	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	93-96
29036814-8	2017	Moreover, this curcumin-mediated suppression of neuroinflammation reduced the progression of p25-induced tau/amyloid pathology and in turn ameliorated the p25-induced cognitive impairments.	Curcumin	15-23	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	155-158
27231954-0	2017	Curcumin Promotes Osteosarcoma Cell Death by Activating miR-125a/ERRalpha Signal Pathway.	Curcumin	0-8	microRNA 125a	Homo sapiens	56-64
27231954-5	2017	In addition, we found that curcumin suppressed the ERRalpha gene expression through upregulation of miR-125a.	Curcumin	27-35	microRNA 125a	Homo sapiens	100-108
27231954-6	2017	Data from this study revealed a novel mechanism for curcumin-mediated apoptotic cell death, which involves tumor cell killing via activating miR-125a/ERRalpha pathway.	Curcumin	52-60	microRNA 125a	Homo sapiens	141-149
27979493-6	2017	Furthermore, curcumin decreased Evans blue extravasation, matrix metallopeptidase-9 expression, and the number of Iba-1-positive microglia in treated mice compared with SAH mice.	Curcumin	13-21	matrix metallopeptidase 9	Mus musculus	58-83
27979493-8	2017	CONCLUSIONS: We demonstrated that curcumin inhibits microglial activation and matrix metallopeptidase-9 expression, thereby reducing brain edema and attenuating post-SAH BBB disruption in mice.	Curcumin	34-42	matrix metallopeptidase 9	Mus musculus	78-103
28167853-0	2017	Curcumin Alters Neural Plasticity and Viability of Intact Hippocampal Circuits and Attenuates Behavioral Despair and COX-2 Expression in Chronically Stressed Rats.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	117-122
27830358-6	2017	In curcumin-treated cells, methylation of DLC1 promoter was reduced and active forms of RhoA and Cdc42 were also decreased.	Curcumin	3-11	cell division cycle 42	Homo sapiens	97-102
29163755-6	2017	Moreover, drugs (fenofibrate and sitagliptin) and several vegetable compounds (extracts from Brassicaceae, berberine, curcumin, and capsaicin) are able to induce UCP2 expression level and to exert beneficial effects on the occurrence of vascular damage.	Curcumin	118-126	uncoupling protein 2	Homo sapiens	162-166
27779649-11	2016	Curcumin alone and combined with paclitaxel increased p53, Bid, caspase-3, caspase-8 and Bax gene expression in MDA-MB-231, whereas Bcl-xL decreased such expression in MDA-MB-231 cells.	Curcumin	0-8	caspase 8	Homo sapiens	75-84
27241764-10	2016	Curcumin supplementation significantly lowered TAG content and decreased the protein expression of LXR-alpha (43%) and SREBP1c (59%) in the liver.	Curcumin	0-8	sterol regulatory element binding transcription factor 1	Rattus norvegicus	119-126
27241764-11	2016	Furthermore, curcumin suppressed the expression of lipogenic enzymes, ACLY (95%), ACC (50%) and FAS (77%) in rats fed with high-fructose diet.	Curcumin	13-21	ATP citrate lyase	Rattus norvegicus	70-74
28929026-3	2017	This study attempted to examine whether the Curcumin longa herb, which is known to have anti-inflammatory property, can modulate cellular inflammatory responses by regulating HMGB1 release.	Curcumin	44-52	high mobility group box 1	Mus musculus	175-180
28646616-8	2017	Moreover, the NF-kappaB has been activated in human macrophages after IAV infection, while administration of curcumin inhibited NF-kappaB signaling pathway via promoting the expression of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha), and inhibiting the translocation of p65 from cytoplasm to nucleus.	Curcumin	109-117	RELA proto-oncogene, NF-kB subunit	Homo sapiens	324-327
28669709-7	2017	Our main finding indicates that the addition of curcumin concomitantly with LPS caused the greatest decrease in NLRP3 S-glutathionylation and a respective increase in caspase-1 S-glutathionylation, which appears to favor protein-protein interactions in the NLRP3 complex.	Curcumin	48-56	caspase 1	Mus musculus	167-176
28861154-7	2017	STAT3 pathway was involved in curcumin-induced tumor inhibition, in which phosphorylation of STAT3 and JAK in ectopic xenograft were both declined after curcumin treatment, and the STAT3-regulated promoter activation of VEGF, Bcl-xL, Cyclin D1 was also significantly reduced after treatment.	Curcumin	30-38	cyclin D1	Homo sapiens	234-243
28861154-7	2017	STAT3 pathway was involved in curcumin-induced tumor inhibition, in which phosphorylation of STAT3 and JAK in ectopic xenograft were both declined after curcumin treatment, and the STAT3-regulated promoter activation of VEGF, Bcl-xL, Cyclin D1 was also significantly reduced after treatment.	Curcumin	153-161	cyclin D1	Homo sapiens	234-243
28579298-3	2017	This review will focus on the effects of curcumin (CUR), berberine (BBR) and resveratrol (RES), on the PI3K/PTEN/Akt/mTORC1/GSK-3 pathway, with a special focus on GSK-3.	Curcumin	41-49	CREB regulated transcription coactivator 1	Mus musculus	117-123
28579298-3	2017	This review will focus on the effects of curcumin (CUR), berberine (BBR) and resveratrol (RES), on the PI3K/PTEN/Akt/mTORC1/GSK-3 pathway, with a special focus on GSK-3.	Curcumin	51-54	CREB regulated transcription coactivator 1	Mus musculus	117-123
28529240-9	2017	Curcumin-mediated inhibition of ROS, down-regulation of caspases, restoration of MMP, and recovery of cell viability were partially reversed by HO-1 inhibitor (SnPP).	Curcumin	0-8	caspase 9	Mus musculus	56-64
28534138-0	2017	A Chemically Modified Curcumin (CMC 2.24) Inhibits Nuclear Factor kappaB Activation and Inflammatory Bone Loss in Murine Models of LPS-Induced Experimental Periodontitis and Diabetes-Associated Natural Periodontitis.	Curcumin	22-30	COX assembly mitochondrial protein 2	Mus musculus	32-37
28534138-1	2017	The purpose of this study was to assess the effect of a novel chemically modified curcumin (CMC 2.24) on NF-kappaB and MAPK signaling and inflammatory cytokine production in two experimental models of periodontal disease in rats.	Curcumin	82-90	C-x(9)-C motif containing 2	Rattus norvegicus	92-97
28595079-7	2017	Renal protein expression of mitogen activated protein kinases (MAPKs) (p-JNK, p-ERK1/2) and glucose regulated protein 78, CHOP were increased in NASH induced mice and curcumin treatment attenuated these increased expressions.	Curcumin	167-175	mitogen-activated protein kinase 3	Mus musculus	80-86
28741112-3	2017	Until now, only two-scaffold triazinone and curcumin have been reported as BACE-1 and GSK-3beta dual inhibitors.	Curcumin	44-52	glycogen synthase kinase 3 alpha	Homo sapiens	86-95
28725008-7	2017	In silico studies of interactions between curcumin or gingerol and myostatin (MSTN; an inhibitor of myogenesis) and their observed affinities for activin receptor type IIB (ACVRIIB) suggested curcumin and gingerol reduce the interaction between MSTN and ACVRIIB.	Curcumin	192-200	activin receptor IIB	Mus musculus	146-171
28265769-9	2017	RESULTS: Treatment with 50 muM curcumin significantly increased the mRNA expression of the differentiation genes thyroglobulin (TG) and sodium iodide symporter (NIS) in all three cell lines and induced inhibition of cell proliferation, apoptosis, and decrease of NF-kappaB p65 activity.	Curcumin	31-39	RELA proto-oncogene, NF-kB subunit	Homo sapiens	263-276
28587210-2	2017	Curcumin is a natural anti-cancer agent that inhibits the metastasis of various cancers by modulating the expression of micro (mi) RNAs such as miR-98, which acts as a tumor suppressor.	Curcumin	0-8	microRNA 98	Homo sapiens	144-150
28587210-3	2017	This study investigated the effect of curcumin on miR-98 expression and in vitro cell line growth and invasiveness in lung cancer.	Curcumin	38-46	microRNA 98	Homo sapiens	50-56
28587210-4	2017	Curcumin treatment enhanced the expression of miR-98 and reduced that of the miR-98 target gene LIN28A as well as matrix metalloproteinase (MMP) 2 and MMP9 in vitro and in vivo.	Curcumin	0-8	microRNA 98	Homo sapiens	46-52
28587210-4	2017	Curcumin treatment enhanced the expression of miR-98 and reduced that of the miR-98 target gene LIN28A as well as matrix metalloproteinase (MMP) 2 and MMP9 in vitro and in vivo.	Curcumin	0-8	microRNA 98	Homo sapiens	77-83
28587210-4	2017	Curcumin treatment enhanced the expression of miR-98 and reduced that of the miR-98 target gene LIN28A as well as matrix metalloproteinase (MMP) 2 and MMP9 in vitro and in vivo.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	114-146
28587210-7	2017	Induction of miR-98 by curcumin treatment suppressed MMP2 and MMP9 by targeting LIN28A.	Curcumin	23-31	microRNA 98	Homo sapiens	13-19
28587210-7	2017	Induction of miR-98 by curcumin treatment suppressed MMP2 and MMP9 by targeting LIN28A.	Curcumin	23-31	matrix metallopeptidase 2	Homo sapiens	53-57
28575427-0	2017	Corrigendum for "Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Fed Male Mice".	Curcumin	33-41	fibroblast growth factor 21	Mus musculus	61-66
28289922-0	2017	Curcumin inhibits lipopolysaccharide (LPS)-induced endotoxemia and airway inflammation through modulation of sequential release of inflammatory mediators (TNF-alpha and TGF-beta1) in murine model.	Curcumin	0-8	transforming growth factor, beta 1	Mus musculus	169-178
28601309-4	2017	Curcumin"s role as an AHR ligand may modulate its effects to induce colon cancer cell death, and this role may be enhanced via structural modification of the curcumin backbone.	Curcumin	0-8	aryl hydrocarbon receptor	Homo sapiens	22-25
28601309-4	2017	Curcumin"s role as an AHR ligand may modulate its effects to induce colon cancer cell death, and this role may be enhanced via structural modification of the curcumin backbone.	Curcumin	158-166	aryl hydrocarbon receptor	Homo sapiens	22-25
29258259-3	2017	In human cancer cell lines, curcumin has been shown to decrease ornithine decarboxylase (ODC) activity, a rate-limiting enzyme in polyamine biosynthesis that is frequently upregulated in cancer and other rapidly proliferating tissues.	Curcumin	28-36	ornithine decarboxylase 1	Homo sapiens	64-87
28601309-6	2017	Moreover, to ascertain the ability of curcumin, RL66 and RL118 to activate the AHR and evaluate if this activation has any effect on CRC cell death.	Curcumin	38-46	aryl hydrocarbon receptor	Homo sapiens	79-82
29258259-3	2017	In human cancer cell lines, curcumin has been shown to decrease ornithine decarboxylase (ODC) activity, a rate-limiting enzyme in polyamine biosynthesis that is frequently upregulated in cancer and other rapidly proliferating tissues.	Curcumin	28-36	ornithine decarboxylase 1	Homo sapiens	89-92
29258259-4	2017	Numerous studies have demonstrated that pretreatment with curcumin can abrogate carcinogen-induced ODC activity and tumor development in rodent tumorigenesis models targeting various organs.	Curcumin	58-66	ornithine decarboxylase 1	Homo sapiens	99-102
28950235-4	2017	Recent studies revealed that only two scaffolds i.e. triazinone and curcumin act as a dual inhibitor against BACE-1 and GSK-3beta.	Curcumin	68-76	glycogen synthase kinase 3 alpha	Homo sapiens	120-129
28264607-0	2017	Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice.	Curcumin	29-37	microRNA 155	Mus musculus	74-86
28264607-7	2017	RESULTS AND DISCUSSION: Curcumin efficiently inhibited LPS-induced cytokines (TNF-alpha, IL-6) and microRNA-155 (miR-155) expression (p &lt; 0.05) without affecting the normally growth of Raw264.7 and THP-1 cells (IC50 21.8 and 22.3 muM at 48 h, respectively).	Curcumin	24-32	microRNA 155	Mus musculus	99-111
28264607-7	2017	RESULTS AND DISCUSSION: Curcumin efficiently inhibited LPS-induced cytokines (TNF-alpha, IL-6) and microRNA-155 (miR-155) expression (p &lt; 0.05) without affecting the normally growth of Raw264.7 and THP-1 cells (IC50 21.8 and 22.3 muM at 48 h, respectively).	Curcumin	24-32	microRNA 155	Mus musculus	113-120
28264607-8	2017	Moreover, the levels of cytokines were suppressed by curcumin in miR-155 mimics transfected cells (p &lt; 0.05).	Curcumin	53-61	microRNA 155	Mus musculus	65-72
28264607-11	2017	MicroRNA-155 level and cytokines were also reduced in curcumin-treated mice (p &lt; 0.05).	Curcumin	54-62	microRNA 155	Mus musculus	0-12
28264607-12	2017	CONCLUSIONS: Curcumin"s ability to suppress LPS-induced inflammatory response may be due to the inhibition of miR-155.	Curcumin	13-21	microRNA 155	Mus musculus	110-117
29201217-8	2017	Treatment with 10 microM curcumin for 48 h also significantly reduced the phosphorylation levels of mechanistic target of rapamycin (mTOR), ribosomal protein S6, phosphoinositide 3-kinase and AKT (protein kinase B) in A549 and H1299 cells (P&lt;0.05).	Curcumin	25-33	ribosomal protein S6	Homo sapiens	140-160
29578200-10	2017	Results: EGCG and curcumin at 10 muM concentration reversed EMT, inhibited proliferation and migration through Smad-3 phosphorylation, when induced by TGF-beta1 in ARPE-19 cells.	Curcumin	18-26	SMAD family member 3	Homo sapiens	111-117
28901458-7	2017	In conclusion, the present findings indicate that curcumin may exert protective effects on LIDD development, exerting its action through the regulation of iNOS, COX-2, TGF-beta1/2, MMP-9 and BDNF.	Curcumin	50-58	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	161-166
28919537-9	2017	Critically, curcumin-I co-treatment reversed these changes and showed a noticeable protective effect; both TH expression and locomotor performance was reinstated in intoxicated rats.	Curcumin	12-20	tyrosine hydroxylase	Rattus norvegicus	107-109
28224377-6	2017	Furthermore, curcumin neutralized cholinergic dysfunction involving choline acetyltransferase expression induced by surgery.	Curcumin	13-21	choline acetyltransferase	Mus musculus	68-93
28496336-0	2017	Curcumin exerts its antitumor activity through regulation of miR-7/Skp2/p21 in nasopharyngeal carcinoma cells.	Curcumin	0-8	S-phase kinase associated protein 2	Homo sapiens	67-71
28496336-6	2017	Importantly, we observed that curcumin upregulated the expression of miR-7 and subsequently inhibited Skp2, a direct miR-7 target.	Curcumin	30-38	S-phase kinase associated protein 2	Homo sapiens	102-106
28391351-0	2017	Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axis.	Curcumin	0-8	microRNA 143	Homo sapiens	65-72
28391351-2	2017	The objective of this study was to explore the interaction between curcumin and PGK1, an oncogene in the FOXD3/miR-143 axis, in prostate cancer therapy.	Curcumin	67-75	microRNA 143	Homo sapiens	111-118
28391351-4	2017	MiR-143 was dramatically upregulated by curcumin.	Curcumin	40-48	microRNA 143	Homo sapiens	0-7
28216009-4	2017	A clear induction of glutathione (GSH)-related antioxidant defenses was observed at 96h in the gills of curcumin exposed animals (10 and 30muM), including GSH levels, and the activity of glutathione reductase (GR), glutathione peroxidase (GPx), and glutathione S-transferase (GST).	Curcumin	104-112	glutathione peroxidase 2	Crassostrea gigas	215-237
28216009-4	2017	A clear induction of glutathione (GSH)-related antioxidant defenses was observed at 96h in the gills of curcumin exposed animals (10 and 30muM), including GSH levels, and the activity of glutathione reductase (GR), glutathione peroxidase (GPx), and glutathione S-transferase (GST).	Curcumin	104-112	glutathione peroxidase 2	Crassostrea gigas	239-242
28469791-8	2017	Treating with curcumin repressed the Foxp3 gene transcription in Tregs; the Tregs were then converted into Th1 cells.	Curcumin	14-22	forkhead box P3	Homo sapiens	37-42
28469791-9	2017	The results also revealed that Foxp3 bound T-bet to prevent IFN-gamma expression in CD4+ T cells, which was abolished by treating with curcumin.	Curcumin	135-143	forkhead box P3	Homo sapiens	31-36
28469791-10	2017	In conclusion, the administration of curcumin can convert Tregs to Th1 cells via repressing Foxp3 expression and enhancing IFN-gamma production.	Curcumin	37-45	forkhead box P3	Homo sapiens	92-97
28399135-4	2017	The literature evidenced that naturally occurring curcumin demonstrates relatively specific and non-competitive inhibition towards human recombinant ALR2 over ALR1 and AKR1B10; however beta-diketone moiety of curcumin is a specific substrate for liver AKRs and accountable for it"s rapid in vivo metabolism.	Curcumin	50-58	aldo-keto reductase family 1 member B10	Homo sapiens	168-175
28399135-4	2017	The literature evidenced that naturally occurring curcumin demonstrates relatively specific and non-competitive inhibition towards human recombinant ALR2 over ALR1 and AKR1B10; however beta-diketone moiety of curcumin is a specific substrate for liver AKRs and accountable for it"s rapid in vivo metabolism.	Curcumin	209-217	aldo-keto reductase family 1 member B10	Homo sapiens	168-175
28167449-5	2017	Pharmacological activity of curcumin is mediated by modulation of several pathways, such as JAK-2/STAT3, thus inhibiting melanoma cell migration and invasion and enhancing apoptosis of these cells.	Curcumin	28-36	Janus kinase 2	Homo sapiens	92-97
27697644-6	2016	A subset of these compounds, such as curcumin and resveratrol, affect multiple epigenetic processes, including DNMT inhibition, HDAC inactivation, MBP suppression, HAT activation, and microRNA modulation.	Curcumin	37-45	myelin basic protein	Homo sapiens	147-150
27894336-0	2016	Curcumin and long-chain Omega-3 polyunsaturated fatty acids for Prevention of type 2 Diabetes (COP-D): study protocol for a randomised controlled trial.	Curcumin	0-8	COPD	Homo sapiens	95-100
27877129-2	2016	This study aimed to evaluate the effect of curcumin on TGF-beta induced differentiation of lung fibroblasts to myofibroblasts and explore the underlying mechanism.	Curcumin	43-51	transforming growth factor, beta 1	Mus musculus	55-63
27877129-8	2016	We found that curcumin and rosiglitazone inhibited the proliferation and TGF-beta induced differentiation of mouse lung fibroblasts.	Curcumin	14-22	transforming growth factor, beta 1	Mus musculus	73-81
27877129-10	2016	Furthermore, curcumin and rosiglitazone upregulated PPAR-gamma and downregulated PDGFR-beta expression in mouse lung fibroblasts.	Curcumin	13-21	peroxisome proliferator activated receptor gamma	Mus musculus	52-62
27755959-0	2016	Protective role of curcumin on renal ischemia reperfusion injury via attenuating the inflammatory mediators and Caspase-3.	Curcumin	19-27	caspase 3	Rattus norvegicus	112-121
28167449-7	2017	Potential anti-cancer activity of curcumin and its analogues is also mediated by modulation of miRNAs such as miR21, that is implicated in cell cycle regulation and apoptosis through down-regulation of PTEN and PDCD4 proteins.	Curcumin	34-42	programmed cell death 4	Homo sapiens	211-216
28843521-0	2017	Curcumin suppresses proliferation and in vitro invasion of human prostate cancer stem cells by ceRNA effect of miR-145 and lncRNA-ROR.	Curcumin	0-8	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	130-133
28338387-10	2017	According to our results, 100 nM curcumin and RG108 significantly induced neurite outgrowth of PC-12 Adh cells with 50 nM NGF.	Curcumin	33-41	nerve growth factor	Rattus norvegicus	122-125
28338387-12	2017	Strikingly, curcumin and NGF combination upregulated GAP-43 and beta-tubulin mRNA expression levels excessively.	Curcumin	12-20	growth associated protein 43	Rattus norvegicus	53-59
28338387-13	2017	In conclusion, curcumin was found to be more effective than RG108 on neuronal differentiation and neurite outgrowth of PC-12 Adh cells in a combination with NGF.	Curcumin	15-23	nerve growth factor	Rattus norvegicus	157-160
28336111-0	2017	Hepatoprotective effects of curcumin in rats after bile duct ligation via downregulation of Rac1 and NOX1.	Curcumin	28-36	Rac family small GTPase 1	Rattus norvegicus	92-96
28843521-4	2017	The expression levels of cell cycle proteins (Ccnd1 and Cdk4) and stem cell markers (Oct4, CD44, and CD133) were decreased in curcumin-treated HuPCaSCs.	Curcumin	126-134	cyclin D1	Homo sapiens	46-51
28843521-4	2017	The expression levels of cell cycle proteins (Ccnd1 and Cdk4) and stem cell markers (Oct4, CD44, and CD133) were decreased in curcumin-treated HuPCaSCs.	Curcumin	126-134	cyclin dependent kinase 4	Homo sapiens	56-60
27677346-9	2017	CONCLUSION: Curcumin synergistically increases the effects of IFN-beta/RA on breast cancer cells.	Curcumin	12-20	interferon beta 1	Homo sapiens	62-70
28843521-4	2017	The expression levels of cell cycle proteins (Ccnd1 and Cdk4) and stem cell markers (Oct4, CD44, and CD133) were decreased in curcumin-treated HuPCaSCs.	Curcumin	126-134	prominin 1	Homo sapiens	101-106
27996348-5	2017	Compared with FZD alone group, curcumin pretreatment significantly reduced the expression of phospho (p)-p38, cyclin D1, p-checkpoint kinase 1 (ChK1) and breast cancer associated gene 1 (BRCA1) protein, followed to attenuate S phase arrest.	Curcumin	31-39	cyclin D1	Homo sapiens	110-119
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	20-28	solute carrier organic anion transporter family member 1A2	Homo sapiens	56-94
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	20-28	solute carrier organic anion transporter family member 1A2	Homo sapiens	96-100
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	214-222	solute carrier organic anion transporter family member 1A2	Homo sapiens	56-94
28843521-7	2017	Curcumin induced high miR-145 expression and inhibited the expression of lncRNA-ROR.	Curcumin	0-8	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	80-83
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	214-222	solute carrier organic anion transporter family member 1A2	Homo sapiens	96-100
28843521-11	2017	Thus, curcumin suppresses the proliferation, in vitro invasion, and tumorigenicity of HuPCaSCs through ceRNA effect of miR-145 and lncRNA-ROR caused.	Curcumin	6-14	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	138-141
28967875-0	2017	Combination curcumin and (-)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway.	Curcumin	12-20	chemokine (C-X-C motif) ligand 15	Mus musculus	137-141
28134362-5	2017	XRD, TGA, DSC, EDX, FT-IR and fluorescence spectroscopic analysis confirm that both CTAB and curcumin act as capping and stabilizing agents for Au NWs as well as Au NPs - there is no remarkable difference in the curcumin/CTAB content between Au NWs and NPs prepared in different pH environments.	Curcumin	93-101	T-box transcription factor 1	Homo sapiens	5-8
28992163-6	2017	We found that both insulin and curcumin-stimulated ChREBP expression in Akt-independent but MEK/ERK-dependent manner, involving the inactivation of the transcriptional repressor Oct-1.	Curcumin	31-39	midkine	Mus musculus	92-95
28134362-5	2017	XRD, TGA, DSC, EDX, FT-IR and fluorescence spectroscopic analysis confirm that both CTAB and curcumin act as capping and stabilizing agents for Au NWs as well as Au NPs - there is no remarkable difference in the curcumin/CTAB content between Au NWs and NPs prepared in different pH environments.	Curcumin	93-101	desmocollin 3	Homo sapiens	10-13
28179291-8	2017	Expression of FGF2, MMP2, VEGF, HGF, TF and FVII was reduced by AS-IV and curcumin alone.	Curcumin	74-82	matrix metallopeptidase 2	Homo sapiens	20-24
27725901-0	2016	Curcumin inhibits cell growth and invasion and induces apoptosis through down-regulation of Skp2 in pancreatic cancer cells.	Curcumin	0-8	S-phase kinase associated protein 2	Homo sapiens	92-96
28992163-9	2017	Our study hence suggests the existence of a novel signaling cascade Pak1/MEK/ERK/Oct-1 for both insulin and curcumin in exerting their glucose-lowering effect via promoting hepatic ChREBP production, supports the recognition of beneficial functions of ChREBP, and brings us a new overview on dietary polyphenols.	Curcumin	108-116	midkine	Mus musculus	73-76
27725901-7	2016	The molecular basis of curcumin-mediated cell growth inhibition we identified is that curcumin significantly suppressed Skp2 expression and subsequently induced p21 expression.	Curcumin	23-31	S-phase kinase associated protein 2	Homo sapiens	120-124
28179291-8	2017	Expression of FGF2, MMP2, VEGF, HGF, TF and FVII was reduced by AS-IV and curcumin alone.	Curcumin	74-82	hepatocyte growth factor	Homo sapiens	32-35
27967217-0	2017	Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Diet-Fed Male Mice.	Curcumin	16-24	fibroblast growth factor 21	Mus musculus	44-49
28676971-6	2017	Elevated ROS also increased the expression of COX-2 and APE1 enzymes and pretreatment of Curcumin and Quercetin decreased COX-2 expression and increased APE1 expression in the oxidatively stressed U-87 MG cells.	Curcumin	89-97	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	153-157
27967217-1	2017	We found previously that short-term curcumin gavage stimulated mouse hepatic fibroblast growth factor 21 (Fgf21) expression.	Curcumin	36-44	fibroblast growth factor 21	Mus musculus	77-104
27967217-1	2017	We found previously that short-term curcumin gavage stimulated mouse hepatic fibroblast growth factor 21 (Fgf21) expression.	Curcumin	36-44	fibroblast growth factor 21	Mus musculus	106-111
27967217-3	2017	Fgf21 stimulation was observed at messenger RNA and protein levels in mice with daily curcumin gavage for 4 or 8 days and in primary hepatocytes with curcumin treatment.	Curcumin	86-94	fibroblast growth factor 21	Mus musculus	0-5
27967217-3	2017	Fgf21 stimulation was observed at messenger RNA and protein levels in mice with daily curcumin gavage for 4 or 8 days and in primary hepatocytes with curcumin treatment.	Curcumin	150-158	fibroblast growth factor 21	Mus musculus	0-5
27967217-4	2017	Using peroxisome proliferator-activated receptor alpha (PPARalpha) agonist and antagonist, along with luciferase reporter and chromatin immune-precipitation approaches, we determined that curcumin stimulates Fgf21 transcription in a mechanism involving PPARalpha activation.	Curcumin	188-196	fibroblast growth factor 21	Mus musculus	208-213
27967217-7	2017	Importantly, hepatocytes from HFD-fed mice showed a loss of response to FGF21 treatment on Erk phosphorylation and the expression of Egr1 and cFos; this response was restored in hepatocytes from HFD-fed mice with curcumin intervention.	Curcumin	213-221	fibroblast growth factor 21	Mus musculus	72-77
27967217-8	2017	This investigation expanded our mechanistic understanding of the metabolic beneficial effects of dietary curcumin intervention involving the regulation of Fgf21 production and the attenuation of HFD-induced Fgf21 resistance.	Curcumin	105-113	fibroblast growth factor 21	Mus musculus	155-160
27967217-8	2017	This investigation expanded our mechanistic understanding of the metabolic beneficial effects of dietary curcumin intervention involving the regulation of Fgf21 production and the attenuation of HFD-induced Fgf21 resistance.	Curcumin	105-113	fibroblast growth factor 21	Mus musculus	207-212
27866296-0	2017	Intranasal Curcumin Inhibits Pulmonary Fibrosis by Modulating Matrix Metalloproteinase-9 (MMP-9) in Ovalbumin-Induced Chronic Asthma.	Curcumin	11-19	matrix metallopeptidase 9	Mus musculus	62-88
27866296-0	2017	Intranasal Curcumin Inhibits Pulmonary Fibrosis by Modulating Matrix Metalloproteinase-9 (MMP-9) in Ovalbumin-Induced Chronic Asthma.	Curcumin	11-19	matrix metallopeptidase 9	Mus musculus	90-95
27866296-6	2017	Intranasal administration of curcumin significantly inhibited airway inflammation and pulmonary fibrosis, where MMP-9 activities were decreased along with alpha-smooth muscle actin (alpha-SMA), MMP-9, TIMP-1, and eotaxin expressions.	Curcumin	29-37	matrix metallopeptidase 9	Mus musculus	112-117
27866296-6	2017	Intranasal administration of curcumin significantly inhibited airway inflammation and pulmonary fibrosis, where MMP-9 activities were decreased along with alpha-smooth muscle actin (alpha-SMA), MMP-9, TIMP-1, and eotaxin expressions.	Curcumin	29-37	matrix metallopeptidase 9	Mus musculus	194-199
27725901-7	2016	The molecular basis of curcumin-mediated cell growth inhibition we identified is that curcumin significantly suppressed Skp2 expression and subsequently induced p21 expression.	Curcumin	86-94	S-phase kinase associated protein 2	Homo sapiens	120-124
27725901-8	2016	These findings suggested thattargeting Skp2 by curcumin could be a promising therapeutic strategy for the treatment of PC patients.	Curcumin	47-55	S-phase kinase associated protein 2	Homo sapiens	39-43
27502306-7	2016	Similarly, ALP activity and expression of bone-related molecules including Runx2, BMP2, and Osterix were also decreased in VSMCs treated with curcumin.	Curcumin	142-150	bone morphogenetic protein 2	Rattus norvegicus	82-86
27502306-8	2016	In addition, flow cytometry analysis and caspase-3 activity assay revealed that curcumin treatment significantly suppressed apoptosis of VSMCs, which plays an important role during vascular calcification.	Curcumin	80-88	caspase 3	Rattus norvegicus	41-50
27551266-7	2016	Curcumin-resveratrol co-treatment decreased the expression of pro-apoptotic proteins like cleaved caspase 3, 8 and 9, cleaved PARP, Apaf1, FasL, tBid.	Curcumin	0-8	apoptotic peptidase activating factor 1	Rattus norvegicus	132-137
27551266-7	2016	Curcumin-resveratrol co-treatment decreased the expression of pro-apoptotic proteins like cleaved caspase 3, 8 and 9, cleaved PARP, Apaf1, FasL, tBid.	Curcumin	0-8	Fas ligand	Rattus norvegicus	139-143
27551266-9	2016	Curcumin-resveratrol decreased the expression of p53 dependent apoptotic genes like Fas, FasL, Bax, Bcl2, and Apaf1.	Curcumin	0-8	Fas ligand	Rattus norvegicus	89-93
29085504-0	2017	Curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a.	Curcumin	0-8	microRNA 15a	Homo sapiens	134-141
28077837-7	2017	Curcumin significantly suppressed the levels of Wnt3a, LRP6, phospho-LRP6, beta-catenin, phospho-beta-catenin, C-myc, and survivin.	Curcumin	0-8	Wnt family member 3A	Homo sapiens	48-53
29085504-2	2017	The aim of the present study was to investigate whether curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer through Bcl-2 and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), and by upregulating microRNA-15a (miR-15a).	Curcumin	56-64	microRNA 15a	Homo sapiens	231-243
28071969-0	2017	Curcumin induces apoptosis in human leukemic cell lines through an IFIT2-dependent pathway.	Curcumin	0-8	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	67-72
27551266-9	2016	Curcumin-resveratrol decreased the expression of p53 dependent apoptotic genes like Fas, FasL, Bax, Bcl2, and Apaf1.	Curcumin	0-8	apoptotic peptidase activating factor 1	Rattus norvegicus	110-115
28071969-3	2017	In the present study, we demonstrated that curcumin induced G2/M cell cycle arrest and apoptosis by increasing the expression levels of cleaved caspase-3, cleaved PARP and decreasing the expression of BCL-2 in U937 human leukemic cells but not in K562 cells.	Curcumin	43-51	collagen type XI alpha 2 chain	Homo sapiens	163-167
29085504-2	2017	The aim of the present study was to investigate whether curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer through Bcl-2 and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), and by upregulating microRNA-15a (miR-15a).	Curcumin	56-64	microRNA 15a	Homo sapiens	245-252
28071969-4	2017	We found some interferon induced genes, especially interferon-induced protein with tetratricopeptide repeats 2 (IFIT2), were significantly upregulated when treated with curcumin in U937 cells by gene expression chip array, and further confirmed that the expression of IFIT2 was obviously higher in U937 than that in K562 cells by Western blot assay.	Curcumin	169-177	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	51-110
28071969-4	2017	We found some interferon induced genes, especially interferon-induced protein with tetratricopeptide repeats 2 (IFIT2), were significantly upregulated when treated with curcumin in U937 cells by gene expression chip array, and further confirmed that the expression of IFIT2 was obviously higher in U937 than that in K562 cells by Western blot assay.	Curcumin	169-177	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	112-117
27525306-0	2016	Curcumin inhibited HGF-induced EMT and angiogenesis through regulating c-Met dependent PI3K/Akt/mTOR signaling pathways in lung cancer.	Curcumin	0-8	hepatocyte growth factor	Homo sapiens	19-22
27525306-4	2016	This study found that curcumin inhibited hepatocyte growth factor (HGF)-induced migration and EMT-related morphological changes in A549 and PC-9 cells.	Curcumin	22-30	hepatocyte growth factor	Homo sapiens	41-65
27525306-4	2016	This study found that curcumin inhibited hepatocyte growth factor (HGF)-induced migration and EMT-related morphological changes in A549 and PC-9 cells.	Curcumin	22-30	hepatocyte growth factor	Homo sapiens	67-70
27525306-5	2016	Moreover, pretreatment with curcumin blocked HGF-induced c-Met phosphorylation and downstream activation of Akt, mTOR, and S6.	Curcumin	28-36	hepatocyte growth factor	Homo sapiens	45-48
28071969-4	2017	We found some interferon induced genes, especially interferon-induced protein with tetratricopeptide repeats 2 (IFIT2), were significantly upregulated when treated with curcumin in U937 cells by gene expression chip array, and further confirmed that the expression of IFIT2 was obviously higher in U937 than that in K562 cells by Western blot assay.	Curcumin	169-177	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	268-273
28071969-5	2017	In addition, inhibiting the expression of IFIT2 by shRNA in U937 rescued curcumin-induced apoptosis and exogenous overexpression of IFIT2 by lentiviral transduction or treating with IFNgamma in K562 cells enhanced anti-cancer activity of curcumin.	Curcumin	73-81	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	42-47
28071969-5	2017	In addition, inhibiting the expression of IFIT2 by shRNA in U937 rescued curcumin-induced apoptosis and exogenous overexpression of IFIT2 by lentiviral transduction or treating with IFNgamma in K562 cells enhanced anti-cancer activity of curcumin.	Curcumin	238-246	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	42-47
27525306-8	2016	In human umbilical vein endothelial cells (HUVECs), we found that curcumin also significantly inhibited PI3K/Akt/mTOR signaling and induced apoptosis and reduced migration and tube formation of HGF-treated HUVEC.	Curcumin	66-74	hepatocyte growth factor	Homo sapiens	194-197
27525306-10	2016	Collectively, these findings indicated that curcumin could inhibit HGF-promoted EMT and angiogenesis by targeting c-Met and blocking PI3K/Akt/mTOR pathways.	Curcumin	44-52	hepatocyte growth factor	Homo sapiens	67-70
28071969-5	2017	In addition, inhibiting the expression of IFIT2 by shRNA in U937 rescued curcumin-induced apoptosis and exogenous overexpression of IFIT2 by lentiviral transduction or treating with IFNgamma in K562 cells enhanced anti-cancer activity of curcumin.	Curcumin	238-246	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	132-137
27405665-3	2016	We first demonstrated that curcumin, like docetaxel (DTX), can selectively target CD11b(+)Ly6G(+)Ly6C(low) granulocytic (G)-MDSCs, sparing CD11b(+)Ly6G(-)Ly6C(high) M-MDSCs, with reduced tumor burden in 4T1-Neu tumor-bearing mice.	Curcumin	27-35	lymphocyte antigen 6 complex, locus G	Mus musculus	90-94
27405665-3	2016	We first demonstrated that curcumin, like docetaxel (DTX), can selectively target CD11b(+)Ly6G(+)Ly6C(low) granulocytic (G)-MDSCs, sparing CD11b(+)Ly6G(-)Ly6C(high) M-MDSCs, with reduced tumor burden in 4T1-Neu tumor-bearing mice.	Curcumin	27-35	lymphocyte antigen 6 complex, locus G	Mus musculus	147-151
29085504-5	2017	Furthermore, curcumin activated miR-15a expression by human laryngeal cancer cells.	Curcumin	13-21	microRNA 15a	Homo sapiens	32-39
29085504-6	2017	Suppression of miR-15a expression reversed the anticancer effect of curcumin on cell proliferation of human laryngeal cancer cells and increased Bcl-2 and PI3K/Akt protein expression in AMC-HN-8 cells treated with 40 microM of curcumin.	Curcumin	68-76	microRNA 15a	Homo sapiens	15-22
28941865-0	2017	Effect of curcumin on acute spinal cord injury in mice via inhibition of inflammation and TAK1 pathway.	Curcumin	10-18	mitogen-activated protein kinase kinase kinase 7	Mus musculus	90-94
28941865-11	2017	Curcumin decreased the phosphorylation levels of TGF-beta-activated kinase 1 (TAK1) protein, leading to decreased phosphorylation levels of MKK6 and p38 MAPKs, key players in the microglia-mediated inflammatory response.	Curcumin	0-8	mitogen-activated protein kinase kinase kinase 7	Mus musculus	49-76
28941865-11	2017	Curcumin decreased the phosphorylation levels of TGF-beta-activated kinase 1 (TAK1) protein, leading to decreased phosphorylation levels of MKK6 and p38 MAPKs, key players in the microglia-mediated inflammatory response.	Curcumin	0-8	mitogen-activated protein kinase kinase kinase 7	Mus musculus	78-82
27381056-0	2016	Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1beta via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling.	Curcumin	0-8	Janus kinase 2	Homo sapiens	123-127
28941865-11	2017	Curcumin decreased the phosphorylation levels of TGF-beta-activated kinase 1 (TAK1) protein, leading to decreased phosphorylation levels of MKK6 and p38 MAPKs, key players in the microglia-mediated inflammatory response.	Curcumin	0-8	mitogen-activated protein kinase kinase 6	Mus musculus	140-144
27381056-4	2016	Additionally, repeated curcumin treatment significantly inhibited the aggregation of the NALP1 inflammasome and the activation of the JAK2-STAT3 cascade in spinal astrocytes.	Curcumin	23-31	Janus kinase 2	Homo sapiens	134-138
27381056-6	2016	Our results suggest that curcumin attenuated neuropathic pain and down-regulated the production of spinal mature IL-1beta by inhibiting the aggregation of NALP1 inflammasome and the activation of the JAK2-STAT3 cascade in astrocytes.	Curcumin	25-33	Janus kinase 2	Homo sapiens	200-204
28941865-11	2017	Curcumin decreased the phosphorylation levels of TGF-beta-activated kinase 1 (TAK1) protein, leading to decreased phosphorylation levels of MKK6 and p38 MAPKs, key players in the microglia-mediated inflammatory response.	Curcumin	0-8	mitogen-activated protein kinase 14	Mus musculus	149-152
28535906-8	2017	We found that curcumin inhibited cell proliferation and triggered apoptosis in PC, which is associated with increased expression of PTEN and p73.	Curcumin	14-22	tumor protein p73	Homo sapiens	141-144
26912222-14	2016	Curcumin-inhibited thrombin-induced CCN2 synthesis in human gingival fibroblasts is caused by the suppression of latent TGFbeta1 activation.	Curcumin	0-8	cellular communication network factor 2	Homo sapiens	36-40
29113362-4	2017	Here, we designed novel kind of poly(lactide-co-glycolic acid) (PLGA) nanoparticles by loading with Abeta generation inhibitor S1 (PQVGHL peptide) and curcumin to target the detrimental factors in AD development and by conjugating with brain targeting peptide CRT (cyclic CRTIGPSVC peptide), an iron-mimic peptide that targets transferrin receptor (TfR), to improve BBB penetration.	Curcumin	151-159	transferrin receptor	Mus musculus	327-347
25963729-8	2016	Curcumin-mediated neuroprotection against BPA-induced neurotoxicity involved activation of the Wnt/beta-catenin signaling pathway, which was confirmed by the use of Wnt specific activators (LiCl and GSK-3beta siRNA) and inhibitor (Dkk-1).	Curcumin	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	199-208
25963729-8	2016	Curcumin-mediated neuroprotection against BPA-induced neurotoxicity involved activation of the Wnt/beta-catenin signaling pathway, which was confirmed by the use of Wnt specific activators (LiCl and GSK-3beta siRNA) and inhibitor (Dkk-1).	Curcumin	0-8	dickkopf WNT signaling pathway inhibitor 1	Rattus norvegicus	231-236
25963729-9	2016	BPA-mediated increased beta-catenin phosphorylation, decreased GSK-3beta levels, and beta-catenin nuclear translocation were significantly reversed by curcumin, leading to enhanced neurogenesis.	Curcumin	151-159	glycogen synthase kinase 3 beta	Rattus norvegicus	63-72
25963729-10	2016	Curcumin-induced protective effects on neurogenesis were blocked by Dkk-1 in NSC culture treated with BPA.	Curcumin	0-8	dickkopf WNT signaling pathway inhibitor 1	Rattus norvegicus	68-73
29113362-4	2017	Here, we designed novel kind of poly(lactide-co-glycolic acid) (PLGA) nanoparticles by loading with Abeta generation inhibitor S1 (PQVGHL peptide) and curcumin to target the detrimental factors in AD development and by conjugating with brain targeting peptide CRT (cyclic CRTIGPSVC peptide), an iron-mimic peptide that targets transferrin receptor (TfR), to improve BBB penetration.	Curcumin	151-159	transferrin receptor	Mus musculus	349-352
28870897-6	2017	Detailed analyses revealed that the mTORC1 and p53 signaling pathways are main targets of curcumin.	Curcumin	90-98	CREB regulated transcription coactivator 1	Mus musculus	36-42
26862043-5	2016	Improvement of all parameters was detected with increase of caspase-3 in both curcumin-treated groups that confirmed curcumin ameliorative effects against AP through induction of apoptosis and inhibition of micro-thrombosis, inflammation, and oxidative stress.	Curcumin	78-86	caspase 3	Rattus norvegicus	60-69
26862043-5	2016	Improvement of all parameters was detected with increase of caspase-3 in both curcumin-treated groups that confirmed curcumin ameliorative effects against AP through induction of apoptosis and inhibition of micro-thrombosis, inflammation, and oxidative stress.	Curcumin	117-125	caspase 3	Rattus norvegicus	60-69
28882947-8	2017	The ability of methoxyphenols to inhibit LPS-stimulated Cox-2 gene expression declined in the order curcumin &gt;&gt; isoeugenol &gt; bis-eugenol &gt;&gt; eugenol, and the rank of ability was related to their omega value.	Curcumin	100-108	prostaglandin-endoperoxide synthase 2	Mus musculus	56-61
27041069-0	2016	Chromatin remodeling by curcumin alters endogenous aryl hydrocarbon receptor signaling.	Curcumin	24-32	aryl hydrocarbon receptor	Homo sapiens	51-76
28677733-10	2017	Importantly, the IFN-gamma-induced increase in the expression levels of MIG, IP-10 and I-TAC in the INS-1 cells was strongly inhibited by SFN, but not by other natural substances, such as curcumin, sanguinarine, resveratrol, triptolide and epigallocatechin gallate (EGCG), suggesting the specificity of SFN in downregulating the levels of these chemokines.	Curcumin	188-196	C-X-C motif chemokine ligand 9	Rattus norvegicus	72-75
27012210-0	2016	Curcumin suppresses 4-hydroxytamoxifen resistance in breast cancer cells by targeting SLUG/Hexokinase 2 pathway.	Curcumin	0-8	hexokinase 2	Homo sapiens	91-103
27012210-7	2016	Combination of curcumin and 4-OHT suppressed SLUG and HK2 expression, leading to mitochondrion-mediated apoptosis.	Curcumin	15-23	hexokinase 2	Homo sapiens	54-57
27551516-3	2016	Here, we characterized how mTORC1 responds to cell death induced by various anticancer drugs such rapamycin, etoposide, cisplatin, curcumin, staurosporine and Fas ligand.	Curcumin	131-139	CREB regulated transcription coactivator 1	Mus musculus	27-33
26978516-6	2016	Furthermore, curcumin significantly increased key mRNA levels of HK2, PKM2, LDHA, CES, Cpt1, Cpt2, FASN, and ATP5b and decreased levels of GLUT2 and ACC1 to enhance glycolysis and inhibit lipid metabolism and TCA cycle.	Curcumin	13-21	pyruvate kinase M1/2	Rattus norvegicus	70-74
26978516-6	2016	Furthermore, curcumin significantly increased key mRNA levels of HK2, PKM2, LDHA, CES, Cpt1, Cpt2, FASN, and ATP5b and decreased levels of GLUT2 and ACC1 to enhance glycolysis and inhibit lipid metabolism and TCA cycle.	Curcumin	13-21	lactate dehydrogenase A	Rattus norvegicus	76-80
26978516-6	2016	Furthermore, curcumin significantly increased key mRNA levels of HK2, PKM2, LDHA, CES, Cpt1, Cpt2, FASN, and ATP5b and decreased levels of GLUT2 and ACC1 to enhance glycolysis and inhibit lipid metabolism and TCA cycle.	Curcumin	13-21	fatty acid synthase	Rattus norvegicus	99-103
26978516-6	2016	Furthermore, curcumin significantly increased key mRNA levels of HK2, PKM2, LDHA, CES, Cpt1, Cpt2, FASN, and ATP5b and decreased levels of GLUT2 and ACC1 to enhance glycolysis and inhibit lipid metabolism and TCA cycle.	Curcumin	13-21	ATP synthase F1 subunit beta	Rattus norvegicus	109-114
26590820-1	2016	The present study aims to investigate the effects of both garlic and curcumin through evaluating their therapeutic properties as antioxidants on liver and kidney functions, hepatic antioxidants and GPx gene expression against aflatoxicosis of O. niloticus.	Curcumin	69-77	glutathione peroxidase	Oreochromis niloticus	198-201
26732833-10	2016	RESULTS: Administration of curcumin decreased TNF-alpha, TNFR2, and caspase 8 without affecting TNFR1 levels.	Curcumin	27-35	TNF receptor superfamily member 1B	Rattus norvegicus	57-62
26732833-12	2016	CONCLUSIONS: The cytoprotective role of curcumin relies on its ability to decrease the TNFR2 mRNA and enhance the antiapoptotic molecules RIP and TRAF2 to decrease the apoptotic pathway via decreasing the caspase 8.	Curcumin	40-48	TNF receptor superfamily member 1B	Rattus norvegicus	87-92
26688832-2	2016	Data presented here demonstrate that the anti-inflammatory, anti-obesity phytochemical curcumin blocked Skp2 protein accumulation during early adipocyte hyperplasia.	Curcumin	87-95	S-phase kinase associated protein 2	Homo sapiens	104-108
26688832-5	2016	In support of this hypothesis, curcumin markedly increased p27 protein half-life as well as attenuated ubiquitin proteasome activity suggesting that inhibition of targeted p27 proteolysis occurred through curcumin-mediated attenuation of Skp2 and 26S proteasome activity.	Curcumin	31-39	S-phase kinase associated protein 2	Homo sapiens	238-242
26688832-5	2016	In support of this hypothesis, curcumin markedly increased p27 protein half-life as well as attenuated ubiquitin proteasome activity suggesting that inhibition of targeted p27 proteolysis occurred through curcumin-mediated attenuation of Skp2 and 26S proteasome activity.	Curcumin	205-213	S-phase kinase associated protein 2	Homo sapiens	238-242
26833194-5	2016	In this report, we show that the protein levels of gadd45alpha, whose transcript levels are increased during DNA damage and stress signals, are upregulated following curcumin treatment in a dose- and time-dependent manner.	Curcumin	166-174	growth arrest and DNA damage inducible alpha	Homo sapiens	51-62
26490992-7	2016	These results demonstrated a p73-dependent mechanism for curcumin-induced apoptosis that involves the mitochondria-mediated pathway.	Curcumin	57-65	tumor protein p73	Homo sapiens	29-32
26826337-0	2016	Curcumin inhibits metastasis in human papillary thyroid carcinoma BCPAP cells via down-regulation of the TGF-beta/Smad2/3 signaling pathway.	Curcumin	0-8	SMAD family member 2	Homo sapiens	114-119
26826337-8	2016	Further evidence showed that curcumin decreased TGF-beta1-mediated phosphorylation of Smad2 and Smad3.	Curcumin	29-37	SMAD family member 2	Homo sapiens	86-91
26826337-8	2016	Further evidence showed that curcumin decreased TGF-beta1-mediated phosphorylation of Smad2 and Smad3.	Curcumin	29-37	SMAD family member 3	Homo sapiens	96-101
26826337-9	2016	These results revealed that curcumin inhibited the TGF-beta1-induced epithelial-mesenchymal transition (EMT) via down-regulation of Smad2/3 signaling pathways.	Curcumin	28-36	SMAD family member 2	Homo sapiens	132-139
26893544-6	2016	Curcumin synergistically potentiated the cytotoxic effect of etoposide, and it intensified apoptosis and phosphorylation of the histone H2AX induced by this cytostatic drug in leukemic HL-60 cells.	Curcumin	0-8	H2A.X variant histone	Homo sapiens	136-140
26796279-9	2016	The combination of LY294002, PI3K inhibitor, and curcumin induced cell cycle arrest by decreasing CDK4, CDK2 and cyclin E2 in Bcl-2+ MCF-7 cells.	Curcumin	49-57	cyclin dependent kinase 2	Homo sapiens	104-108
26796279-9	2016	The combination of LY294002, PI3K inhibitor, and curcumin induced cell cycle arrest by decreasing CDK4, CDK2 and cyclin E2 in Bcl-2+ MCF-7 cells.	Curcumin	49-57	cyclin E2	Homo sapiens	113-122
26796279-12	2016	The combination of wedelolactone, NFkappaB inhibitor, and curcumin acted different on SSAT expression in wt MCF-7 and Bcl-2+ MCF-7 cells.	Curcumin	58-66	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	86-90
26796279-13	2016	NFkappaB inhibition increased the SSAT after curcumin treatment in Bcl-2 overexpressed MCF-7 cells.	Curcumin	45-53	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	34-38
25596714-0	2016	Curcumin inhibits LPA-induced invasion by attenuating RhoA/ROCK/MMPs pathway in MCF7 breast cancer cells.	Curcumin	0-8	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	59-63
25596714-0	2016	Curcumin inhibits LPA-induced invasion by attenuating RhoA/ROCK/MMPs pathway in MCF7 breast cancer cells.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	64-68
25596714-16	2016	Concurrently, RhoA and ROCK activities and expression levels of RhoA, ROCK1, ROCK2, MMP2 and MMP9 were down-regulated by curcumin in a concentration-dependent manner.	Curcumin	121-129	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	23-27
25596714-16	2016	Concurrently, RhoA and ROCK activities and expression levels of RhoA, ROCK1, ROCK2, MMP2 and MMP9 were down-regulated by curcumin in a concentration-dependent manner.	Curcumin	121-129	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	70-75
25596714-16	2016	Concurrently, RhoA and ROCK activities and expression levels of RhoA, ROCK1, ROCK2, MMP2 and MMP9 were down-regulated by curcumin in a concentration-dependent manner.	Curcumin	121-129	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	77-82
25596714-16	2016	Concurrently, RhoA and ROCK activities and expression levels of RhoA, ROCK1, ROCK2, MMP2 and MMP9 were down-regulated by curcumin in a concentration-dependent manner.	Curcumin	121-129	matrix metallopeptidase 2	Homo sapiens	84-88
25596714-17	2016	In conclusion, RhoA/ROCK/MMPs pathway activation is involved in LPA-induced invasion in MCF-7 cells; curcumin inhibited LPA-induced invasion in MCF-7 cells by attenuating RhoA/ROCK/MMPs pathway.	Curcumin	101-109	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	176-180
25596714-17	2016	In conclusion, RhoA/ROCK/MMPs pathway activation is involved in LPA-induced invasion in MCF-7 cells; curcumin inhibited LPA-induced invasion in MCF-7 cells by attenuating RhoA/ROCK/MMPs pathway.	Curcumin	101-109	matrix metallopeptidase 2	Homo sapiens	181-185
26648392-5	2016	The results demonstrated that curcumin was able to significantly alleviate motor dysfunction and increase suppressed tyrosine hydroxylase (TH) activity in the SNpc of rotenone (ROT)-injured rats.	Curcumin	30-38	tyrosine hydroxylase	Rattus norvegicus	117-137
26893768-0	2016	Curcumin mediates reversion of HGF-induced epithelial-mesenchymal transition via inhibition of c-Met expression in DU145 cells.	Curcumin	0-8	hepatocyte growth factor	Homo sapiens	31-34
26893768-5	2016	In addition, it was observed that curcumin abrogated HGF-induced DU145 cell scattering and invasion.	Curcumin	34-42	hepatocyte growth factor	Homo sapiens	53-56
26893768-6	2016	Furthermore, curcumin was able to effectively inhibit the HGF-induced increase in the levels of vimentin by downregulating the expression of phosphorylated c-Met, extracellular signal-regulated kinase and Snail.	Curcumin	13-21	hepatocyte growth factor	Homo sapiens	58-61
26824354-0	2016	Curcumin Ameliorates the Reduction Effect of PGE2 on Fibrillar beta-Amyloid Peptide (1-42)-Induced Microglial Phagocytosis through the Inhibition of EP2-PKA Signaling in N9 Microglial Cells.	Curcumin	0-8	prostaglandin E receptor 2	Homo sapiens	149-152
26824354-10	2016	Taken together, these data suggested that curcumin restored the attenuating effect of PGE2 on fAbeta42-induced microglial phagocytosis via a signaling mechanism involving EP2 and PKA.	Curcumin	42-50	prostaglandin E receptor 2	Homo sapiens	171-174
26706937-5	2016	Curcumin and capsaicin treatments significantly reduced hepatic fat accumulation and leptin levels; liver fetuin-A expression was decreased significantly by the curcumin treatment.	Curcumin	0-8	leptin	Rattus norvegicus	85-91
26706937-6	2016	Curcumin and capsaicin treatments attenuated hepatic fat accumulation and increased leptin levels related to inflammation.	Curcumin	0-8	leptin	Rattus norvegicus	84-90
28071969-6	2017	These results indicated for the first time that curcumin induced leukemic cell apoptosis via an IFIT2-dependent signaling pathways.	Curcumin	48-56	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	96-101
28596967-0	2017	Prdx6 Upregulation by Curcumin Attenuates Ischemic Oxidative Damage via SP1 in Rats after Stroke.	Curcumin	22-30	peroxiredoxin 6	Rattus norvegicus	0-5
28596967-2	2017	Curcumin (Cur) treatment elicits neuroprotective effects against cerebral ischemic injury, and the associated mechanisms may involve Prdx6.	Curcumin	0-8	peroxiredoxin 6	Rattus norvegicus	133-138
27771282-7	2017	These findings establish the regulatory role AhR of in controlling BCRP expression at the BBB and confirm quercetin, naringin, 17-beta-estradiol, and curcumin as novel inducers and down-regulators of BCRP gene, protein expression and functional transporter activity and hence potential novel target sites and candidates for enhancing CNS drug delivery.	Curcumin	150-158	aryl hydrocarbon receptor	Homo sapiens	45-48
29065403-6	2017	RESULTS: Our results indicated that Curcumin-NP reversed oxidative stress, growth inhibition and cell apoptosis accompanied with down-regulation of apoptotic markers Caspase-3 and GRP-78 in vitro.	Curcumin	36-44	caspase 3	Rattus norvegicus	166-175
29069652-0	2017	Protective Effect of Curcumin Against Oxidative Stress-Induced Injury in Rats with Parkinson"s Disease Through the Wnt/ beta-Catenin Signaling Pathway.	Curcumin	21-29	Wnt family member 3A	Rattus norvegicus	115-118
29069652-1	2017	BACKGROUND/AIMS: The study aimed to investigate the protective effect of curcumin against oxidative stress-induced injury of Parkinson"s disease (PD) through the Wnt/beta-catenin signaling pathway in rats.	Curcumin	73-81	Wnt family member 3A	Rattus norvegicus	162-165
29069652-8	2017	Curcumin enhanced viability, survival and adhesion and attenuated apoptosis of deutocerebrum primary cells by activating the Wnt/beta-catenin signaling pathway.	Curcumin	0-8	Wnt family member 3A	Rattus norvegicus	125-128
28812431-0	2017	Oral administration of curcumin attenuates visceral hyperalgesia through inhibiting phosphorylation of TRPV1 in rat model of ulcerative colitis.	Curcumin	23-31	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	103-108
28812431-6	2017	A significant increase in colonic expression of TRPV1 and pTRPV1 was observed in dextran sulfate sodium-treated rats and this was reversed by oral administration of curcumin.	Curcumin	165-173	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	48-53
28812431-7	2017	TRPV1 expression in L6-S1 dorsal root ganglion was increased in the small- to medium-sized isolectin B4-positive non-peptidergic and calcitonin gene-related peptide-positive peptidergic neurons in dextran sulfate sodium-treated rats and oral administration of curcumin mitigated such changes.	Curcumin	260-268	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
28812431-8	2017	In the HEK293 cell line stably expressing hTRPV1, curcumin (1, 3 microm) inhibited phorbol myristate acetate-induced upregulation of membrane TRPV1.	Curcumin	50-58	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-48
28812431-8	2017	In the HEK293 cell line stably expressing hTRPV1, curcumin (1, 3 microm) inhibited phorbol myristate acetate-induced upregulation of membrane TRPV1.	Curcumin	50-58	transient receptor potential cation channel subfamily V member 1	Homo sapiens	43-48
29098059-0	2017	Curcumin Reverses the Diazepam-Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 1/2/NF-kappaB Pathway in Brain.	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	98-105
28008233-7	2016	Fluorescent microscopy of FA-DABA-SMA loaded with curcumin revealed a significant internalization of the dye by human pancreatic PANC-1 cancer cells compared to those with unfunctionalized polymers (SMA).	Curcumin	50-58	survival of motor neuron 1, telomeric	Homo sapiens	34-37
27657825-10	2016	Curcumin induced G0/G1 arrest in DU-145 cells, and G0/G1 phase related regulatory factors Cyclin D1 and CDK2 expressions were inhibited.	Curcumin	0-8	cyclin dependent kinase 2	Homo sapiens	104-108
27466310-7	2016	After the administration of curcumin for 6 months, the results showed that the expression of an insulin receptor (InR) and insulin receptor substrate (IRS)-1 decreased in the hippocampal CA1 area of the APPswe/PS1dE9 double transgenic mice, while the expression of phosphatidylinositol-3 kinase (PI3K), phosphorylated PI3K (p-PI3K), serine-threonine kinase (AKT) and phosphorylated AKT (p-AKT) increased.	Curcumin	28-36	insulin receptor	Mus musculus	96-112
27466310-7	2016	After the administration of curcumin for 6 months, the results showed that the expression of an insulin receptor (InR) and insulin receptor substrate (IRS)-1 decreased in the hippocampal CA1 area of the APPswe/PS1dE9 double transgenic mice, while the expression of phosphatidylinositol-3 kinase (PI3K), phosphorylated PI3K (p-PI3K), serine-threonine kinase (AKT) and phosphorylated AKT (p-AKT) increased.	Curcumin	28-36	insulin receptor	Mus musculus	114-117
27738325-0	2016	Antitumor activity of curcumin is involved in down-regulation of YAP/TAZ expression in pancreatic cancer cells.	Curcumin	22-30	Yes1 associated transcriptional regulator	Homo sapiens	65-68
27738325-9	2016	We further measured that overexpression of YAP enhanced cell proliferation and abrogated the cytotoxic effects of curcumin on PC cells.	Curcumin	114-122	Yes1 associated transcriptional regulator	Homo sapiens	43-46
27738325-10	2016	Moreover, we found that curcumin markedly down-regulated YAP and TAZ expression and subsequently suppressed Notch-1 expression.	Curcumin	24-32	Yes1 associated transcriptional regulator	Homo sapiens	57-60
27994638-8	2016	Predicted binding mode of a new curcumin derivative in complex with 12-LOX active site.	Curcumin	32-40	lysyl oxidase	Mus musculus	71-74
27994638-9	2016	b Curcumin itself in the 12-LOX active site biological distribution of 99mTc-curcumin derivative complex in solid tumor bearing Albino mice.	Curcumin	2-10	lysyl oxidase	Mus musculus	28-31
27994638-9	2016	b Curcumin itself in the 12-LOX active site biological distribution of 99mTc-curcumin derivative complex in solid tumor bearing Albino mice.	Curcumin	77-85	lysyl oxidase	Mus musculus	28-31
27689333-0	2016	Curcumin targets the TFEB-lysosome pathway for induction of autophagy.	Curcumin	0-8	transcription factor EB	Homo sapiens	21-25
27412471-6	2016	The maleate-induced epithelial damage, evaluated by claudin-2 and occludin expressions, was ameliorated by curcumin.	Curcumin	107-115	occludin	Homo sapiens	66-74
26765996-0	2016	Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin.	Curcumin	122-130	chemokine (C-X3-C motif) ligand 1	Mus musculus	13-24
26765996-0	2016	Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin.	Curcumin	122-130	chemokine (C-X3-C motif) ligand 1	Mus musculus	26-29
26765996-9	2016	Curcumin protected against neuronal damage in hippocampal DG of fructose-fed mice by inhibiting microglia activation and suppressed FKN/CX3CR1 up-regulation in the neuronal network.	Curcumin	0-8	chemokine (C-X3-C motif) ligand 1	Mus musculus	132-135
27629417-5	2016	GILZ was inducible by curcumin in macrophage cell lines, primary human monocyte-derived macrophages, and murine bone marrow-derived macrophages.	Curcumin	22-30	TSC22 domain family member 3	Homo sapiens	0-4
27777559-0	2016	Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-kappaB and P2X7R Signaling in PMA-Induced Macrophages.	Curcumin	0-8	MYD88 innate immune signal transduction adaptor	Homo sapiens	58-63
27600729-8	2016	In addition, curcumin treatment reduced apoptosis in the testis, and decreased expression of Fas, Bax and cleaved-caspase 3, as well as increased expression of Bcl-xl.	Curcumin	13-21	Bcl2-like 1	Rattus norvegicus	160-166
27766950-8	2016	Molecular docking analyses were performed to check the potential of two natural inhibitors, rutin and curcumin to bind CCND1.	Curcumin	102-110	cyclin D1	Homo sapiens	119-124
27766950-13	2016	The ligands - rutin and curcumin bounded with CCND1 with good affinity.	Curcumin	24-32	cyclin D1	Homo sapiens	46-51
27624003-0	2016	Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation.	Curcumin	0-8	nuclear receptor subfamily 1 group H member 4	Homo sapiens	72-75
27624003-5	2016	Curcumin, one major compound derived from DNT, exerted the protective effect against cholestasis through farnesoid X receptor (FXR), which has been focused as potential therapeutic targets for treating cholestasis.	Curcumin	0-8	nuclear receptor subfamily 1 group H member 4	Homo sapiens	127-130
27624003-6	2016	The underlying mechanism of curcumin against cholestasis was restoring bile acid homeostasis and antagonizing inflammatory responses in a FXR-dependent manner and in turn contributed to overall cholestasis attenuation.	Curcumin	28-36	nuclear receptor subfamily 1 group H member 4	Homo sapiens	138-141
27618095-6	2016	The mixture containing quercetin, curcumin, green tea, cruciferex, and resveratrol (PB) demonstrated significant inhibition of the growth of Fanconi anemia head and neck squamous cell carcinoma and dose-dependent inhibition of cell proliferation, matrix metalloproteinase (MMP)-2 and -9 secretion, cell migration and invasion through Matrigel.	Curcumin	34-42	matrix metallopeptidase 2	Homo sapiens	247-286
27432244-5	2016	Curcumin induced G1 phase arrest through downregulating the expression of cyclin D3 and cyclin-dependent kinase (CDK)2/6 and upregulating the expression of CDK inhibitor proteins p21 and p27.	Curcumin	0-8	cyclin dependent kinase 2	Homo sapiens	113-118
27203664-7	2016	Furthermore, curcumin increased cluster of differentiation (CD)163 expression, and down-regulated renal expression of antigen II type I receptor (AT1R), endothelin (ET)1, ET receptor type A and B (ETAR and ETBR), CD68 and CD80.	Curcumin	13-21	angiotensin II receptor, type 1a	Rattus norvegicus	146-150
27203664-7	2016	Furthermore, curcumin increased cluster of differentiation (CD)163 expression, and down-regulated renal expression of antigen II type I receptor (AT1R), endothelin (ET)1, ET receptor type A and B (ETAR and ETBR), CD68 and CD80.	Curcumin	13-21	endothelin receptor type A	Rattus norvegicus	197-201
27203664-7	2016	Furthermore, curcumin increased cluster of differentiation (CD)163 expression, and down-regulated renal expression of antigen II type I receptor (AT1R), endothelin (ET)1, ET receptor type A and B (ETAR and ETBR), CD68 and CD80.	Curcumin	13-21	endothelin receptor type B	Rattus norvegicus	206-210
27203664-7	2016	Furthermore, curcumin increased cluster of differentiation (CD)163 expression, and down-regulated renal expression of antigen II type I receptor (AT1R), endothelin (ET)1, ET receptor type A and B (ETAR and ETBR), CD68 and CD80.	Curcumin	13-21	Cd68 molecule	Rattus norvegicus	213-217
27651779-0	2016	Curcumin upregulates S100 expression and improves regeneration of the sciatic nerve following its complete amputation in mice.	Curcumin	0-8	S100 calcium binding protein A1	Mus musculus	21-25
27651779-7	2016	High and moderate doses of curcumin markedly improved both action potential amplitude of the sciatic nerves and the conduction velocity of the corresponding motor neurons, and upregulated mRNA and protein expression of S100, a marker for Schwann cell proliferation, in L4-6 spinal cord segments.	Curcumin	27-35	S100 calcium binding protein A1	Mus musculus	219-223
27651779-8	2016	These results suggest that curcumin is effective in promoting the repair of complete sciatic nerve amputation injury and that the underlying mechanism may be associated with upregulation of S100 expression.	Curcumin	27-35	S100 calcium binding protein A1	Mus musculus	190-194
27550987-0	2016	BMI1 is downregulated by the natural compound curcumin, but not by bisdemethoxycurcumin and dimethoxycurcumin.	Curcumin	46-54	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	0-4
27550987-3	2016	Curcumin, a major phytochemical in turmeric (Curcuma longa), inhibits the proliferation and survival of many types of cancer cells, both in vitro and in vivo, and has been reported to reduce BMI1 expression in breast cancer cells.	Curcumin	0-8	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	191-195
27550987-4	2016	In this study, effects of curcumin and two analogs (bisdemethoxycurcumin and dimethoxycurcumin) on BMI1 expression were evaluated in DLD-1 colorectal cancer cells.	Curcumin	26-34	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	99-103
27550987-6	2016	All three compounds reduced cell survival, but only the natural compound downregulated BMI1 protein expression; curcumin significantly reduced BMI1 levels more than bisdemethoxycurcumin and dimethoxycurcumin.	Curcumin	112-120	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	143-147
27283735-5	2016	Curcumin treated Tat transfected HEK-293T cells showed a dose and time dependent degradation of Tat protein.	Curcumin	0-8	tyrosine aminotransferase	Homo sapiens	17-20
27283735-5	2016	Curcumin treated Tat transfected HEK-293T cells showed a dose and time dependent degradation of Tat protein.	Curcumin	0-8	tyrosine aminotransferase	Homo sapiens	96-99
27283735-8	2016	Curcumin increased the rate of Tat protein degradation as shown by cycloheximide (CHX) chase assay.	Curcumin	0-8	tyrosine aminotransferase	Homo sapiens	31-34
27448781-0	2016	Curcumin protects against liver fibrosis by attenuating infiltration of Gr1hi monocytes through inhibition of monocyte chemoattractant protein-1.	Curcumin	0-8	lymphocyte antigen 6 complex, locus G	Mus musculus	72-75
27448781-12	2016	Curcumin significantly reduced the expression of TNF-alpha and TGF-beta1, which is in line with the decreased numbers of intrahepatic Gr1hi monocytes.	Curcumin	0-8	transforming growth factor, beta 1	Mus musculus	63-72
27448781-14	2016	CONCLUSIONS: The anti-inflammatory and antifibrotic effects of curcumin could be contributed to its prevention of Gr1hi monocyte infiltration into the injured livers through inhibition of MCP-1.	Curcumin	63-71	lymphocyte antigen 6 complex, locus G	Mus musculus	114-117
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	caspase 8	Homo sapiens	278-287
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	cyclin D1	Homo sapiens	308-317
26927614-2	2016	Conjugation of curcumin (Curc) to albumin (Alb) has been found to increase the aqueous solubility of the drug.	Curcumin	15-23	albumin	Mus musculus	43-46
26927614-2	2016	Conjugation of curcumin (Curc) to albumin (Alb) has been found to increase the aqueous solubility of the drug.	Curcumin	25-29	albumin	Mus musculus	43-46
25980682-5	2016	Curcumin activated ER-resident UPR sensors, such as PERK, IRE-1alpha, and ATF6, and their downstream-signaling proteins in cervical cancer cells, but not in normal epithelial cells and peripheral blood mononuclear cells (PBMCs).	Curcumin	0-8	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	58-68
27035875-4	2016	By immunofluorescence staining, subcellular fractionation and western blotting, the present study demonstrated that curcumin was able to induce G2/M cell cycle arrest and apoptosis by increasing the expression levels of cyclin G2, cleaved caspase-3 and Fas ligand (FasL), and decreasing the expression of cyclin-dependent kinase 1 (CDK1).	Curcumin	116-124	cyclin G2	Homo sapiens	220-229
27035875-7	2016	Furthermore, following knockdown of FoxO1 expression in curcumin-treated U87 cells using FoxO1 small interfering RNA, the expression levels of cyclin G2, cleaved caspase-3 and FasL were inhibited; however, the expression levels of CDK1 were not markedly altered.	Curcumin	56-64	cyclin G2	Homo sapiens	143-152
27010501-1	2016	This work describes the anti-inflammatory effect of the curcumin-analog compound, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate (DM1), and shows that DM1 modulates iNOS and COX-2 gene expression in cultured RAW 264.7 cells and induces autophagy on human melanoma cell line A375.	Curcumin	56-64	cytochrome c oxidase II, mitochondrial	Mus musculus	211-216
26826458-4	2016	Results showed that, 10 muM of curcumin significantly inhibited secretion of inflammatory factors including interleukin (IL)-17,IL-22, IFN-gamma, IL-2, IL-8 and TNF-alpha in T cells by 30-60% in vitro.	Curcumin	31-39	chemokine (C-X-C motif) ligand 15	Mus musculus	152-156
26826458-8	2016	More than 50% level of inflammatory factors including TNF-alpha, IFN-gamma, IL-2, IL-12, IL-22 and IL-23 in mouse serum was decreased by curcumin treatment as well as cyclosporine.	Curcumin	137-145	interleukin 23, alpha subunit p19	Mus musculus	99-104
26776764-7	2016	Treatment with ERK1/2 inhibitor U0126 or curcumin effectively abrogated benzidine-triggered cell proliferation and ERK1/2/AP-1 activation.	Curcumin	41-49	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	122-126
26502886-8	2016	In the presence of 50 nM curcumin, the clearance of resveratrol-3-O-glucuronide and resveratrol-3-O-sulfate reduced in both MRP2-overexpressing MDCKII-UGT1A1 cells and Human UGT1A9-overexpressing HeLa cells.	Curcumin	25-33	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	174-180
27069633-0	2016	UGT concentrations in human rectal tissue after multidose, oral curcumin.	Curcumin	64-72	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	0-3
27069633-2	2016	Therefore, we sought to evaluate the effect of oral curcumin on intestinal UGT expression.	Curcumin	52-60	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	75-78
26422756-9	2016	H2S also increased activator protein 1 (AP-1) binding activity with SIRT3 promoter and this effect was absent in the presence of the specific AP-1 inhibitor, SR11302 or curcumin.	Curcumin	169-177	jun proto-oncogene	Mus musculus	19-38
26422756-9	2016	H2S also increased activator protein 1 (AP-1) binding activity with SIRT3 promoter and this effect was absent in the presence of the specific AP-1 inhibitor, SR11302 or curcumin.	Curcumin	169-177	jun proto-oncogene	Mus musculus	142-146
28053883-12	2017	Furthermore, curcumin treatments increased neuronal viability and attenuated the immunoreactivity for COX-2 and TNF-alpha, in the hippocampus in both protocols.	Curcumin	13-21	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	102-107
26796279-9	2016	The combination of LY294002, PI3K inhibitor, and curcumin induced cell cycle arrest by decreasing CDK4, CDK2 and cyclin E2 in Bcl-2+ MCF-7 cells.	Curcumin	49-57	cyclin dependent kinase 4	Homo sapiens	98-102
26761722-0	2016	Intranasal curcumin ameliorates airway inflammation and obstruction by regulating MAPKinase activation (p38, Erk and JNK) and prostaglandin D2 release in murine model of asthma.	Curcumin	11-19	mitogen-activated protein kinase 14	Mus musculus	104-107
26761722-5	2016	These investigations suggest that intranasal curcumin (2.5 and 5.0 mg/kg) regulates airway inflammation and airway obstruction mainly by modulating cytokine levels (IL-4, 5, IFN-y and TNF-alpha) and sPLA2 activity thereby inhibiting PGD2 release and COX-2 expression.	Curcumin	45-53	cytochrome c oxidase II, mitochondrial	Mus musculus	250-255
26761722-6	2016	Further, the suppression of p38 MAPK, ERK 42/44 and JNK54/56 activation elucidate the mechanism behind the inhibitory role of intranasal curcumin in asthma progression.	Curcumin	137-145	mitogen-activated protein kinase 14	Mus musculus	28-36
26893768-7	2016	In conclusion, the results of the present study demonstrated that curcumin was able to reverse HGF-induced EMT, possibly by inhibiting c-Met expression in DU145 prostate cancer cells.	Curcumin	66-74	hepatocyte growth factor	Homo sapiens	95-98
26638997-10	2016	In conclusion, ICV-streptozotocin-induced Alzheimer"s dementia activates hippocampal Fas ligand-mediated apoptosis, which could be reduced by erythropoietin and/or curcumin treatment.	Curcumin	164-172	Fas ligand	Rattus norvegicus	85-95
28234242-8	2016	CONCLUSIONS: Our findings indicate that dietary curcumin ameliorates western diet-induced atherosclerosis in ApoE-/- mice, which is related to LCN2 down-regulation, anti-hyperlipidemia effect as well as the inhibition of inflammation.	Curcumin	48-56	lipocalin 2	Mus musculus	143-147
28595985-4	2017	The present study was undertaken to evaluate, for the first time, whether curcumin could reduce adipogenesis induced by benzyl butyl phthalate (BBP) via downregulation of the PPARgamma-C/EBPalpha pathway.	Curcumin	74-82	peroxisome proliferator activated receptor gamma	Mus musculus	175-184
26442630-8	2016	In addition, the ATM-specific inhibitor KU-55933 reversed curcumin-induced phosphorylation of H2A.X.	Curcumin	58-66	H2A.X variant histone	Homo sapiens	94-99
26442630-9	2016	These results collectively show that curcumin treatment induced the DNA damage response via triggering an ATM-activated Chk2-Cdc25C-Cdc2 signaling pathway.	Curcumin	37-45	checkpoint kinase 2	Homo sapiens	120-124
26467482-3	2016	The present study explored whether curcumin is able to prevent the cisplatin-induced fibrosis and decreased expression of the TJ and adherens junction (AJ) proteins occludin, claudin-2 and E-cadherin in cisplatin-induced nephrotoxicity.	Curcumin	35-43	occludin	Rattus norvegicus	165-173
26989696-5	2016	In addition, treatment with curcumin remarkably suppressed the increased activity of Rac1, as well as the enhanced expression of gp91(phox) and p47(phox) induced by high glucose.	Curcumin	28-36	Rac family small GTPase 1	Rattus norvegicus	85-89
26437580-1	2016	The aim of this study was to provide insight into how curcumin reduces colon inflammation in the Mdr1a(-/-) mouse model of human inflammatory bowel disease using a combined transcriptomics and proteomics approach.	Curcumin	54-62	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	97-102
26437580-4	2016	Colonic HIS of Mdr1a(-/-) mice fed the AIN-76A diet was higher (P&lt;.001) than FVB mice fed the same diet; the curcumin-supplemented diet reduced colonic HIS (P&lt;.05) in Mdr1a(-/-) mice.	Curcumin	112-120	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	15-20
27475814-0	2016	Retraction Statement: Paper by Qian Y, Ma J, Guo X, Sun J, Yu Y, CaoB, Zhang L, Ding X, Huang J, Shao JF, entitled "Curcumin Enhances the Radiosensitivity ofU87 Cells by Inducing DUSP-2 Up-Regulation" Cell Physiol Biochem 2015;35(4):1381-93.doi: 10.1159/000373959.	Curcumin	116-124	ring finger protein 2	Homo sapiens	80-84
27475814-0	2016	Retraction Statement: Paper by Qian Y, Ma J, Guo X, Sun J, Yu Y, CaoB, Zhang L, Ding X, Huang J, Shao JF, entitled "Curcumin Enhances the Radiosensitivity ofU87 Cells by Inducing DUSP-2 Up-Regulation" Cell Physiol Biochem 2015;35(4):1381-93.doi: 10.1159/000373959.	Curcumin	116-124	dual specificity phosphatase 2	Homo sapiens	179-185
26437580-5	2016	Microarray and proteomics analyses combined with new data analysis tools, such as the Ingenuity Pathways Analysis regulator effects analysis, showed that curcumin"s antiinflammatory activity in Mdr1a(-/-) mouse colon may be mediated by activation of alpha-catenin, which has not previously been reported.	Curcumin	154-162	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	194-199
26437580-7	2016	Key transcription factors and other regulatory molecules (ERK, FN1, TNFSF12 and PI3K complex) activated in inflammation were down-regulated by dietary intervention with curcumin.	Curcumin	169-177	tumor necrosis factor (ligand) superfamily, member 12	Mus musculus	68-75
28595985-4	2017	The present study was undertaken to evaluate, for the first time, whether curcumin could reduce adipogenesis induced by benzyl butyl phthalate (BBP) via downregulation of the PPARgamma-C/EBPalpha pathway.	Curcumin	74-82	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	185-195
28948066-8	2017	Curcumin treatment reduced the expression of p53, caspase-3, and bax/bxl-2 ratio significantly.	Curcumin	0-8	caspase 3	Rattus norvegicus	50-59
26456563-6	2016	Increased expression of UCP1 and other brown adipocyte-specific markers was possibly mediated by curcumin-induced activation of AMP-activated protein kinase (AMPK) based on the fact that inhibition of AMPK by dorsomorphin abolished expression of PRDM16, UCP1 and peroxisome proliferator-activated receptor gamma co-activator 1-alpha while the activator 5-Aminoimidazole-4-carboxamide ribonucleotide elevated expression of these brown marker proteins.	Curcumin	97-105	PR/SET domain 16	Homo sapiens	246-252
26442630-3	2016	In this study, we have reported that curcumin induces significant DNA damage in human papillary thyroid carcinoma BCPAP cells in a dose-dependent manner as evidenced by the upregulated phosphorylation of H2A.X at Ser139, which was further confirmed by the long tails in the comet assay and the increase in the number of TUNEL-positive cells.	Curcumin	37-45	H2A.X variant histone	Homo sapiens	204-209
26442630-7	2016	Interestingly, ATM/ATR activation by curcumin induced phosphorylation of Chk2 (Thr68) followed by that of Cdc25C (Ser216) and Cdc2 (Tyr15), and Cyclin B1 accumulation.	Curcumin	37-45	checkpoint kinase 2	Homo sapiens	73-77
28391715-0	2017	Curcumin sensitizes prostate cancer cells to radiation partly via epigenetic activation of miR-143 and miR-143 mediated autophagy inhibition.	Curcumin	0-8	microRNA 143	Homo sapiens	91-98
26649317-4	2016	Specifically, the ability of polyphenolic natural products, EGCG, curcumin, and resveratrol, to modulate the aggregation of hIAPP is discussed.	Curcumin	66-74	islet amyloid polypeptide	Homo sapiens	124-129
26612707-5	2016	Moreover, Curcumin/CMC-peptide treatment during hypertrophy significantly improved cardiac function by downregulating expression of hypertrophy marker genes (ANF, beta-MHC), apoptotic mediators (Bax, Cytochrome-c) and activity of apoptotic markers (Caspase 3 and PARP); whereas free Curcumin in much higher dose showed minimal improvement during compromised cardiac function.	Curcumin	10-18	caspase 3	Rattus norvegicus	249-258
26585812-0	2015	Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma.	Curcumin	0-8	aryl hydrocarbon receptor	Homo sapiens	127-130
26989696-8	2016	Moreover, curcumin significantly increased Akt and GSK-3beta phosphorylation in cardiomyocytes treated with high glucose.	Curcumin	10-18	glycogen synthase kinase 3 beta	Rattus norvegicus	51-60
28391715-0	2017	Curcumin sensitizes prostate cancer cells to radiation partly via epigenetic activation of miR-143 and miR-143 mediated autophagy inhibition.	Curcumin	0-8	microRNA 143	Homo sapiens	103-110
26585812-6	2015	We also reveal that curcumin suppressed phthalate-induced migration, invasion, and CSC-like cell maintenance through inhibition of the aryl hydrocarbon receptor/ERK/SK1/S1P3 signaling pathway.	Curcumin	20-28	aryl hydrocarbon receptor	Homo sapiens	135-160
28391715-3	2017	In this study, we firstly assessed how curcumin affects the expression of miR-143/miR-145 cluster.	Curcumin	39-47	microRNA 143	Homo sapiens	74-81
26375757-5	2015	Curcumin inhibited expressions of VEGF receptors (VEGFR2 and VEGFR3), as well as downstream signaling such as phosphorylation of ERK and FAK.	Curcumin	0-8	protein tyrosine kinase 2	Homo sapiens	137-140
28391715-5	2017	Our data showed that PC3, DU145 and LNCaP cells treated with curcumin had significantly restored miR-143 and miR-145 expression.	Curcumin	61-69	microRNA 143	Homo sapiens	97-104
26397387-0	2015	Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway.	Curcumin	0-8	Janus kinase 2	Homo sapiens	77-81
26397387-6	2015	Moreover, by molecular docking analysis and tumor sphere assay we discover that curcumin was able to inhibit JAK2 activity and reduce tumor spheres via inhibiting the JAK2/STAT3 signaling pathway.	Curcumin	80-88	Janus kinase 2	Homo sapiens	109-113
28391715-6	2017	Curcumin showed similar effect as 5-AZA-dC on reducing methylation of CpG dinucleotides in miR-143 promoter.	Curcumin	0-8	microRNA 143	Homo sapiens	91-98
26397387-6	2015	Moreover, by molecular docking analysis and tumor sphere assay we discover that curcumin was able to inhibit JAK2 activity and reduce tumor spheres via inhibiting the JAK2/STAT3 signaling pathway.	Curcumin	80-88	Janus kinase 2	Homo sapiens	167-171
27529496-0	2016	Curcumin Protects against Monosodium Glutamate Neurotoxicity and Decreasing NMDA2B and mGluR5 Expression in Rat Hippocampus.	Curcumin	0-8	glutamate receptor, ionotropic, kainate 1	Mus musculus	87-93
28391715-7	2017	In addition, curcumin treatment reduced the expression of DNMT1 and DNMT3B, which contribute to promoter hypermethylation of the miR-143/miR-145 cluster.	Curcumin	13-21	microRNA 143	Homo sapiens	129-136
26802648-8	2016	In conclusion, curcumin may act synergistically with the chemotherapeutic regimen FOLFOX in gastric cancer in vitro and in vivo by inducing apoptosis via Bcl/Bax-caspase 8,9-caspase 3 pathway.	Curcumin	15-23	caspase 8	Homo sapiens	162-171
27457236-6	2016	Suppression of oncomiRs such as miR-21, miR-17-5p, miR-20a, and miR-27a and over-expression of miR-34 a/c and epithelial-mesenchymal transition-suppressor miRNAs are among the most important effects of curcumin on miRNA homeostasis.	Curcumin	202-210	microRNA 34a	Homo sapiens	95-103
26608647-8	2015	While co-incubation with hCG along with several TLR ligands mediated heightened chemo-resistance, TLR-2/6 and TLR-9 ligands increased the phosphorylation of JNK, and TLR-2 and TLR-8 ligands the phosphorylation of ERK in presence of hCG and curcumin, providing evidence of tri-molecular synergy.	Curcumin	240-248	chorionic gonadotropin subunit beta 5	Homo sapiens	25-28
26608647-8	2015	While co-incubation with hCG along with several TLR ligands mediated heightened chemo-resistance, TLR-2/6 and TLR-9 ligands increased the phosphorylation of JNK, and TLR-2 and TLR-8 ligands the phosphorylation of ERK in presence of hCG and curcumin, providing evidence of tri-molecular synergy.	Curcumin	240-248	toll like receptor 9	Homo sapiens	110-115
26608647-12	2015	Co-administration of curcumin along with an anti-hCG vaccine (hCGbeta conjugated to Tetanus Toxoid (TT)) to mice carrying syngeneic tumors resulted in significantly enhanced benefits on animal survival; synergy was demonstrated between anti-hCG antibodies and curcumin in the reduction of tumor cell viability.	Curcumin	21-29	chorionic gonadotropin subunit beta 5	Homo sapiens	62-65
28391715-8	2017	Therefore, we infer that curcumin can restore miR-143 and miR-145 expression via hypomethylation.	Curcumin	25-33	microRNA 143	Homo sapiens	46-53
28391715-13	2017	Based on these findings, we infer that curcumin sensitizes prostate cancer cells to radiation partly via epigenetic activation of miR-143 and miR-143 mediated autophagy inhibition.	Curcumin	39-47	microRNA 143	Homo sapiens	130-137
28391715-13	2017	Based on these findings, we infer that curcumin sensitizes prostate cancer cells to radiation partly via epigenetic activation of miR-143 and miR-143 mediated autophagy inhibition.	Curcumin	39-47	microRNA 143	Homo sapiens	142-149
28611265-9	2017	RESULTS: Curcumin increased the survival percent in rats, decreased -fetoprotein (AFP) concentration, and serum aspartate aminotransferase (AST) activity, and increased serum albumin concentration.	Curcumin	9-17	alpha-fetoprotein	Rattus norvegicus	82-85
26515041-8	2015	The significant cytotoxicity and tubulin inhibition by SA-2 was streamlined by molecular modeling studies where it was docked at the curcumin binding site of tubulin.	Curcumin	133-141	stromal antigen 2	Homo sapiens	55-59
28391869-5	2017	Curcumin along with CTAB act as capping and stabilizing agent for Au NWs/NPs in different temperatures, which is confirmed by XRD, TGA, DSC, EDX and FT-IR data.	Curcumin	0-8	T-box transcription factor 1	Homo sapiens	131-134
26232616-0	2015	Ceramide generation during curcumin-induced apoptosis is controlled by crosstalk among Bcl-2, Bcl-xL, caspases and glutathione.	Curcumin	27-35	caspase 8	Homo sapiens	102-110
26232616-2	2015	We have demonstrated earlier that apoptosis of HL-60 human leukemia cells induced by curcumin is controlled by ceramide generated by neutral sphingomyelinase (nSMase) which contributes to sphingomyelin synthase (SMS) inhibition favoring accumulation of ceramide in cells.	Curcumin	85-93	sphingomyelin phosphodiesterase 2	Homo sapiens	133-157
26232616-2	2015	We have demonstrated earlier that apoptosis of HL-60 human leukemia cells induced by curcumin is controlled by ceramide generated by neutral sphingomyelinase (nSMase) which contributes to sphingomyelin synthase (SMS) inhibition favoring accumulation of ceramide in cells.	Curcumin	85-93	sphingomyelin phosphodiesterase 2	Homo sapiens	159-165
26884838-0	2015	Curcumin improves bone microarchitecture in glucocorticoid-induced secondary osteoporosis mice through the activation of microRNA-365 via regulating MMP-9.	Curcumin	0-8	matrix metallopeptidase 9	Mus musculus	149-154
26884838-10	2015	Curcumin treatment could suppress the expression of MMP-9 in the tibia of GIOP mice.	Curcumin	0-8	matrix metallopeptidase 9	Mus musculus	52-57
26232616-5	2015	These data place nSMase activation downstream of caspase-8 and Bcl-xL and indicate a mutual regulation between nSMase and caspase-3 activity on one hand, and Bcl-2 level on the other hand in curcumin-treated cells.	Curcumin	191-199	sphingomyelin phosphodiesterase 2	Homo sapiens	17-23
28391869-5	2017	Curcumin along with CTAB act as capping and stabilizing agent for Au NWs/NPs in different temperatures, which is confirmed by XRD, TGA, DSC, EDX and FT-IR data.	Curcumin	0-8	desmocollin 3	Homo sapiens	136-139
26232616-5	2015	These data place nSMase activation downstream of caspase-8 and Bcl-xL and indicate a mutual regulation between nSMase and caspase-3 activity on one hand, and Bcl-2 level on the other hand in curcumin-treated cells.	Curcumin	191-199	caspase 8	Homo sapiens	49-58
26884838-11	2015	The present study demonstrated the protective effects of curcumin against bone deteriorations in the experimentally DIOP mice, and the underlying mechanism was mediated, at least partially, through the activation of microRNA-365 via suppressing MMP9.	Curcumin	57-65	matrix metallopeptidase 9	Mus musculus	245-249
26648693-0	2015	Attenuation of myocardial fibrosis with curcumin is mediated by modulating expression of angiotensin II AT1/AT2 receptors and ACE2 in rats.	Curcumin	40-48	angiotensin II receptor, type 2	Rattus norvegicus	108-111
26250869-7	2015	Furthermore, administration of curcumin significantly reduced peritoneal IL-1beta and HMGB-1 concentration induced by LPS and improved the survival of mice suffering from lethal endotoxic shock.	Curcumin	31-39	high mobility group box 1	Mus musculus	86-92
26648693-5	2015	The protein level of the Ang II type 1 (AT1) receptor was reduced, and the Ang II type 2 (AT2) receptor was up-regulated, evidenced by an increased ratio of the AT2 receptor over the AT1 receptor in the curcumin group (1.2+-0.02%) vs in the Ang II group (0.7+-0.03%, P&lt;0.05).	Curcumin	203-211	angiotensin II receptor, type 2	Rattus norvegicus	90-93
28618934-7	2017	Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 and ITGA2B), collagen ( COL5A1), and laminin ( LAMA5) were significantly inhibited by curcumin at messenger RNA and protein levels.	Curcumin	191-199	laminin, alpha 5	Mus musculus	152-157
26648693-5	2015	The protein level of the Ang II type 1 (AT1) receptor was reduced, and the Ang II type 2 (AT2) receptor was up-regulated, evidenced by an increased ratio of the AT2 receptor over the AT1 receptor in the curcumin group (1.2+-0.02%) vs in the Ang II group (0.7+-0.03%, P&lt;0.05).	Curcumin	203-211	angiotensin II receptor, type 2	Rattus norvegicus	161-164
26300394-9	2015	Treatment of SCI rats with curcumin enhanced mRNA levels of Wnt3a, Lrp5, and ctnnb1 and upregulated protein expression of beta-catenin in distal femurs.	Curcumin	27-35	Wnt family member 3A	Rattus norvegicus	60-65
26300394-9	2015	Treatment of SCI rats with curcumin enhanced mRNA levels of Wnt3a, Lrp5, and ctnnb1 and upregulated protein expression of beta-catenin in distal femurs.	Curcumin	27-35	LDL receptor related protein 5	Rattus norvegicus	67-71
29926590-14	2017	CONCLUSIONS: Curcumin can promote the recovery of hindlimb motor function after spinal cord injury in rats.The mechanism is through inhibition of NF-K B to prevent inflammation; And inhibition the expression of Bax and Caspase-3, and promotion the expression of Bcl-2 to prevent apoptosis, so as to accelerate the recovery of motor function in the rats after spinal cord injury.	Curcumin	13-21	caspase 3	Rattus norvegicus	219-228
26538809-5	2015	Furthermore, curcumin enhanced the MPTP-induced activation of microglia and astrocytes in the striatum and increased the expression of glial cell line-derived neurotrophic factor (GDNF) and transforming growth factor-beta1 (TGFbeta1) in the striatum and SVZ.	Curcumin	13-21	glial cell line derived neurotrophic factor	Mus musculus	135-178
26538809-5	2015	Furthermore, curcumin enhanced the MPTP-induced activation of microglia and astrocytes in the striatum and increased the expression of glial cell line-derived neurotrophic factor (GDNF) and transforming growth factor-beta1 (TGFbeta1) in the striatum and SVZ.	Curcumin	13-21	glial cell line derived neurotrophic factor	Mus musculus	180-184
26538809-5	2015	Furthermore, curcumin enhanced the MPTP-induced activation of microglia and astrocytes in the striatum and increased the expression of glial cell line-derived neurotrophic factor (GDNF) and transforming growth factor-beta1 (TGFbeta1) in the striatum and SVZ.	Curcumin	13-21	transforming growth factor, beta 1	Mus musculus	190-222
26538809-5	2015	Furthermore, curcumin enhanced the MPTP-induced activation of microglia and astrocytes in the striatum and increased the expression of glial cell line-derived neurotrophic factor (GDNF) and transforming growth factor-beta1 (TGFbeta1) in the striatum and SVZ.	Curcumin	13-21	transforming growth factor, beta 1	Mus musculus	224-232
26643788-7	2015	Moreover, curcumin diet reduced benzo[a]pyrene-induced activation of NF-kappaB and MAPK signaling and Cox-2 transcription in lung tissues of mice.	Curcumin	10-18	cytochrome c oxidase II, mitochondrial	Mus musculus	102-107
26507910-6	2015	In addition, curcumin suppressed the production of inflammatory cytokines, such as TNF-alpha, IL-1beta, IL-6 and IL-8.	Curcumin	13-21	chemokine (C-X-C motif) ligand 15	Mus musculus	113-117
26166196-8	2015	The findings revealed that curcumin significantly decreased cell proliferation, which was associated with increased expression of the p21/CIP1 and p27/KIP1 cyclin-dependent kinase inhibitors, and inhibited expression of cyclin D1.	Curcumin	27-35	cyclin D1	Homo sapiens	220-229
28391351-9	2017	FOXD3 was also ectopically overexpressed to investigate its effects on curcumin"s regulation of miR-143.	Curcumin	71-79	microRNA 143	Homo sapiens	96-103
28391351-10	2017	RESULTS: Curcumin treatment significantly upregulated miR-143 and decreased prostate cancer cell proliferation and migration.	Curcumin	9-17	microRNA 143	Homo sapiens	54-61
26074474-0	2015	Curcumin Suppresses MAPK Pathways to Reverse Tobacco Smoke-induced Gastric Epithelial-Mesenchymal Transition in Mice.	Curcumin	0-8	mitogen-activated protein kinase homolog MMK2	Nicotiana tabacum	20-24
26074474-8	2015	Treatment of curcumin effectively abrogated TS-triggered gastric activation of ERK1/2 and JNK MAPK pathways, AP-1 proteins, and EMT alterations.	Curcumin	13-21	mitogen-activated protein kinase 3	Mus musculus	79-85
26386842-0	2015	Multiple effects of curcumin on promoting expression of the exon 7-containing SMN2 transcript.	Curcumin	20-28	survival of motor neuron 2, centromeric	Homo sapiens	78-82
26386842-3	2015	The exon 7-containing SMN2 transcript (SMN2_E7+) can be increased by a dietary compound, curcumin, but the involved molecular changes are not clear.	Curcumin	89-97	survival of motor neuron 2, centromeric	Homo sapiens	22-26
26386842-3	2015	The exon 7-containing SMN2 transcript (SMN2_E7+) can be increased by a dietary compound, curcumin, but the involved molecular changes are not clear.	Curcumin	89-97	survival of motor neuron 2, centromeric	Homo sapiens	39-43
26386842-4	2015	Here we have found that in fibroblast cells of a SMA type II patient, curcumin enhanced the inclusion of SMN2 exon 7.	Curcumin	70-78	survival of motor neuron 2, centromeric	Homo sapiens	105-109
26074474-8	2015	Treatment of curcumin effectively abrogated TS-triggered gastric activation of ERK1/2 and JNK MAPK pathways, AP-1 proteins, and EMT alterations.	Curcumin	13-21	mitogen-activated protein kinase homolog MMK2	Nicotiana tabacum	94-98
26074474-8	2015	Treatment of curcumin effectively abrogated TS-triggered gastric activation of ERK1/2 and JNK MAPK pathways, AP-1 proteins, and EMT alterations.	Curcumin	13-21	jun proto-oncogene	Mus musculus	109-113
26074474-9	2015	These results suggest for the first time the protective effects of curcumin in long-term TS exposure-induced gastric MAPK activation and EMT, thus providing new insights into the pathogenesis and chemoprevention of TS-associated gastric cancer.	Curcumin	67-75	mitogen-activated protein kinase homolog MMK2	Nicotiana tabacum	117-121
26386842-7	2015	Interestingly, the curcumin effects on the SMN2 and SRSF1 transcripts were inhibited by a protein deacetylase inhibitor, trichostatin A.	Curcumin	19-27	survival of motor neuron 2, centromeric	Homo sapiens	43-47
28391351-14	2017	Ectopic expression of FOXD3 synergized with curcumin in upregulating miR-143 expression.	Curcumin	44-52	microRNA 143	Homo sapiens	69-76
26386842-9	2015	Thus, curcumin appears to have multiple effects on the SMN2 transcript and its splicing regulators, including the change of alternative splicing and transcript/protein level as well as phosphorylation.	Curcumin	6-14	survival of motor neuron 2, centromeric	Homo sapiens	55-59
26305550-7	2015	The combination of FAPalphac vaccine, CpG and curcumin stimulated FAPalpha antibody production and CD8+ T cell-mediated killing of FAPalpha-expressing stromal cells without adverse reactive effects.	Curcumin	46-54	fibroblast activation protein	Mus musculus	66-74
28391351-15	2017	CONCLUSION: Curcumin inhibits prostate cancer by upregulating miR-143.	Curcumin	12-20	microRNA 143	Homo sapiens	62-69
28273557-0	2017	Curcumin inhibiting Th17 cell differentiation by regulating the metabotropic glutamate receptor-4 expression on dendritic cells.	Curcumin	0-8	glutamate receptor, metabotropic 4	Mus musculus	64-97
28273557-6	2017	Treatment with curcumin significantly reduced IL-6 and IL-23 production by dendritic cells (DC).	Curcumin	15-23	interleukin 23, alpha subunit p19	Mus musculus	55-60
26302188-6	2015	We further found that curcumin interfered with the transforming growth factor-beta (TGF-beta) signaling by reducing the expression of TGF-beta receptor I and inhibiting the expression and phosphorylation of Smad2 and Smad3.	Curcumin	22-30	SMAD family member 2	Homo sapiens	207-212
26302188-6	2015	We further found that curcumin interfered with the transforming growth factor-beta (TGF-beta) signaling by reducing the expression of TGF-beta receptor I and inhibiting the expression and phosphorylation of Smad2 and Smad3.	Curcumin	22-30	SMAD family member 3	Homo sapiens	217-222
26361331-3	2015	We subsequently tried various methods to prepare liposomal curcumin, and eventually succeeded in preparing liposomes with sufficient amounts of curcumin to suppress macrophages by incorporating a complex of curcumin and bovine serum albumin.	Curcumin	144-152	albumin	Mus musculus	227-240
26361331-3	2015	We subsequently tried various methods to prepare liposomal curcumin, and eventually succeeded in preparing liposomes with sufficient amounts of curcumin to suppress macrophages by incorporating a complex of curcumin and bovine serum albumin.	Curcumin	144-152	albumin	Mus musculus	227-240
28259961-8	2017	We found that treatment with curcumin increased miR-7 expression and suppressed ILF2 protein in the PANC-1 cells.	Curcumin	29-37	interleukin enhancer binding factor 2	Homo sapiens	80-84
26515683-9	2015	Moreover, in vitro or in vivo treatment with curcumin, a natural phenolic compound, significantly enhanced CFTR expression and reversed the heat-induced increases in COX-2/PGE2/IL-8, neutrophil infiltration and tissue damage in the airway.	Curcumin	45-53	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	166-171
26515683-10	2015	These results have revealed a CFTR-regulated MAPK/NF-kappaB pathway leading to COX-2/PGE2/IL-8 activation in thermal inhalation injury, and demonstrated therapeutic potential of curcumin for alleviating heat-induced pulmonary inflammation.	Curcumin	178-186	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	79-84
26335331-0	2015	Sulindac, 3,3"-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis.	Curcumin	36-44	APC regulator of WNT signaling pathway	Rattus norvegicus	87-90
26116710-9	2015	The increases in iNOS and cybb mRNA were not attenuated by the AT1 receptor antagonist losartan but abolished by the AP-1 blocker curcumin.	Curcumin	130-138	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-121
28259961-9	2017	Thus, we identified ILF2 as a new downstream target gene of curcumin.	Curcumin	60-68	interleukin enhancer binding factor 2	Homo sapiens	20-24
26036622-0	2015	Curcumin Inhibits Invasiveness and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Through Reducing Matrix Metalloproteinase 2, 9 and Modulating p53-E-Cadherin Pathway.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	118-144
28348486-0	2017	Therapeutic effect of curcumin on experimental colitis mediated by inhibiting CD8+CD11c+ cells.	Curcumin	22-30	integrin subunit alpha X	Homo sapiens	82-87
26036622-3	2015	This study aimed to determine the anti-invasive effect of curcumin on the expression of matrix metalloproteinases (MMPs) and of EMT regulators in OSCC.	Curcumin	58-66	matrix metallopeptidase 2	Homo sapiens	115-119
26036622-5	2015	RESULTS: Our data showed that curcumin treatment not only decreased the expression of MMP-2 and MMP-9 to inhibit invasiveness in oral cancer but also modulated the expression of EMT markers, such as Snail, Twist, and E-cadherin, and induced p53 expression that is crucial to EMT repression.	Curcumin	30-38	matrix metallopeptidase 2	Homo sapiens	86-91
26622667-5	2015	Furthermore, following treatment with curcumin for 24 h, there was a decrease in the expression levels of matrix metalloproteinase (MMP)-2 and -9 as well as proteinase activity in EC cells.	Curcumin	38-46	matrix metallopeptidase 2	Homo sapiens	106-145
26338887-12	2015	Finally, curcumin gavage increased FGF21 expression by 2.1-fold in the mouse liver (P &lt; 0.05) and curcumin treatment increased FGF21 expression in primary hepatocytes.	Curcumin	9-17	fibroblast growth factor 21	Mus musculus	35-40
26338887-12	2015	Finally, curcumin gavage increased FGF21 expression by 2.1-fold in the mouse liver (P &lt; 0.05) and curcumin treatment increased FGF21 expression in primary hepatocytes.	Curcumin	101-109	fibroblast growth factor 21	Mus musculus	130-135
26338887-13	2015	CONCLUSION: These observations suggest that the early beneficial effect of curcumin intervention in dexamethasone-treated mice is the sensitization of insulin signaling, involving the stimulation of FGF21 production, a known insulin sensitizer.	Curcumin	75-83	fibroblast growth factor 21	Mus musculus	199-204
28348486-1	2017	AIM: To verify whether curcumin (Cur) can treat inflammatory bowel disease by regulating CD8+CD11c+ cells.	Curcumin	23-31	integrin subunit alpha X	Homo sapiens	93-98
28110063-0	2017	Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-kappaB translocation.	Curcumin	0-8	high mobility group box 1	Mus musculus	105-110
26538809-7	2015	These results suggest that long-term administration of curcumin blocks the neurotoxicity of MPTP in the nigrostriatal dopaminergic system of the mouse and that the neuroprotective effect might be correlated with the increased expression of GDNF and TGFbeta1.	Curcumin	55-63	glial cell line derived neurotrophic factor	Mus musculus	240-244
28110063-7	2017	Furthermore, curcumin treatment significantly reduced the cytoplasmic translocation of high mobility group box 1 (HMGB1) and the protein expression of toll like receptor 4.	Curcumin	13-21	high mobility group box 1	Mus musculus	87-112
26538809-7	2015	These results suggest that long-term administration of curcumin blocks the neurotoxicity of MPTP in the nigrostriatal dopaminergic system of the mouse and that the neuroprotective effect might be correlated with the increased expression of GDNF and TGFbeta1.	Curcumin	55-63	transforming growth factor, beta 1	Mus musculus	249-257
28110063-7	2017	Furthermore, curcumin treatment significantly reduced the cytoplasmic translocation of high mobility group box 1 (HMGB1) and the protein expression of toll like receptor 4.	Curcumin	13-21	high mobility group box 1	Mus musculus	114-119
26677679-0	2015	[Effect of Curcumin on TGF-beta2 Regulated PPAR-gamma/PDGF-beta Signaling Pathway in Lung Fibroblasts of Mice].	Curcumin	11-19	peroxisome proliferator activated receptor gamma	Mus musculus	43-53
28110063-10	2017	Our data suggest that curcumin reduces the progression of NASH and liver damage, which may act via inhibiting HMGB1-NF-kappaB translocation.	Curcumin	22-30	high mobility group box 1	Mus musculus	110-115
26677679-1	2015	OBJECTIVE: To explore the effect of curcumin on TGF-beta2 regulated peroxisome proliferater activated receptor y (PPAR-gamma)/platelet derived growth factor beta (PDGF-beta) signaling pathway in lung fibroblasts of mice.	Curcumin	36-44	peroxisome proliferator activated receptor gamma	Mus musculus	114-124
26677679-5	2015	Protein levels of PPAR-gamma and collagen-1 were detected using Western blot and ELISA in the blank control group, the TGF-beta2 group, the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group.	Curcumin	166-174	peroxisome proliferator activated receptor gamma	Mus musculus	18-43
27990751-0	2017	Curcumin improves glucose tolerance via stimulation of glucagon-like peptide-1 secretion.	Curcumin	0-8	glucagon	Mus musculus	55-78
26677679-7	2015	Compared with the TGF-beta2 group, mRNA expressions of PPAR-gamma obviously increased in the TGF-beta2 (10 ng/mL) plus curcumin 25 mumol/L group and the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group, higher than that in the TGF-beta2 (10 ng/mL) plus curcumin 5 [mumol/L group (P &lt; 0.05).	Curcumin	119-127	peroxisome proliferator activated receptor gamma	Mus musculus	55-65
26677679-7	2015	Compared with the TGF-beta2 group, mRNA expressions of PPAR-gamma obviously increased in the TGF-beta2 (10 ng/mL) plus curcumin 25 mumol/L group and the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group, higher than that in the TGF-beta2 (10 ng/mL) plus curcumin 5 [mumol/L group (P &lt; 0.05).	Curcumin	179-187	peroxisome proliferator activated receptor gamma	Mus musculus	55-65
26677679-7	2015	Compared with the TGF-beta2 group, mRNA expressions of PPAR-gamma obviously increased in the TGF-beta2 (10 ng/mL) plus curcumin 25 mumol/L group and the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group, higher than that in the TGF-beta2 (10 ng/mL) plus curcumin 5 [mumol/L group (P &lt; 0.05).	Curcumin	179-187	peroxisome proliferator activated receptor gamma	Mus musculus	55-65
26677679-8	2015	mRNA expressions of PPAR-gamma was higher in the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group than in the TGF-beta2 (10 ng/mL) plus curcumin 25 mumol/L group (P &lt; 0.05).	Curcumin	75-83	peroxisome proliferator activated receptor gamma	Mus musculus	20-30
26677679-8	2015	mRNA expressions of PPAR-gamma was higher in the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group than in the TGF-beta2 (10 ng/mL) plus curcumin 25 mumol/L group (P &lt; 0.05).	Curcumin	139-147	peroxisome proliferator activated receptor gamma	Mus musculus	20-30
26102194-0	2015	Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	78-82
27990751-2	2017	Our previous studies demonstrated that curcumin (a yellow pigment of turmeric) significantly increases the secretion of GLP-1 in enteroendocrine L cell line (GLUTag cells).	Curcumin	39-47	glucagon	Mus musculus	120-125
27990751-4	2017	In addition, the molecular target of curcumin-induced GLP-1 secretion has not been clarified.	Curcumin	37-45	glucagon	Mus musculus	54-59
27990751-6	2017	In GLUTag cells, curcumin-induced GLP-1 secretion was associated with G protein-coupled receptor (GPR) 40/120.	Curcumin	17-25	glucagon	Mus musculus	34-39
27990751-8	2017	CONCLUSION: These findings demonstrate the biological function of curcumin as a GLP-1 secretagogue and the possible molecular target that mediates GLP-1 secretion.	Curcumin	66-74	glucagon	Mus musculus	80-85
27990751-8	2017	CONCLUSION: These findings demonstrate the biological function of curcumin as a GLP-1 secretagogue and the possible molecular target that mediates GLP-1 secretion.	Curcumin	66-74	glucagon	Mus musculus	147-152
27990751-9	2017	Increases in the secretion of endogenous GLP-1 induced by curcumin may allow the dosages of other diabetic medicines to be reduced and aid in the prevention of diabetes.	Curcumin	58-66	glucagon	Mus musculus	41-46
28297801-12	2017	The relative expression of occludin was 0.29+-0.03 in the control group, 0.12+-0.02 in the model group, and 0.21+-0.02 in the curcumin intervention group (P &lt; 0.05).	Curcumin	126-134	occludin	Rattus norvegicus	27-35
28297801-14	2017	Curcumin can reduce such damage, and its mechanism of action may be related to up-regulating the expression of occludin in the intestinal mucosa and reducing the levels of TNFalpha and LPS.	Curcumin	0-8	occludin	Rattus norvegicus	111-119
28243065-14	2017	At apoptosis- and autophagy-inducing concentrations, curcumin enhanced the expression levels of TfR1 and IRP1, indicative of iron deprivation induced by curcumin.	Curcumin	53-61	transferrin receptor	Homo sapiens	96-100
28243065-14	2017	At apoptosis- and autophagy-inducing concentrations, curcumin enhanced the expression levels of TfR1 and IRP1, indicative of iron deprivation induced by curcumin.	Curcumin	53-61	aconitase 1	Homo sapiens	105-109
28243065-14	2017	At apoptosis- and autophagy-inducing concentrations, curcumin enhanced the expression levels of TfR1 and IRP1, indicative of iron deprivation induced by curcumin.	Curcumin	153-161	transferrin receptor	Homo sapiens	96-100
28243065-14	2017	At apoptosis- and autophagy-inducing concentrations, curcumin enhanced the expression levels of TfR1 and IRP1, indicative of iron deprivation induced by curcumin.	Curcumin	153-161	aconitase 1	Homo sapiens	105-109
28120490-7	2017	Curcumin did not affect the expression of Notch-1 or its active product NICD, but it did inhibit the expression of MT1-MMP and MMP2 proteins in DU145 cells.	Curcumin	0-8	matrix metallopeptidase 14	Homo sapiens	115-122
28120490-7	2017	Curcumin did not affect the expression of Notch-1 or its active product NICD, but it did inhibit the expression of MT1-MMP and MMP2 proteins in DU145 cells.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	127-131
27817102-10	2017	Of note, the expression of p-Akt increased by curcumin was accompanied by the decreased chemokines MCP-1 and MIP-1 levels and fewer CD68-positive macrophages in the placenta.	Curcumin	46-54	CD68 antigen	Mus musculus	132-136
28123853-6	2017	In this study, we show that the CAF-mediated enhancement of pancreatic cancer cell migration and metastasis was blocked by curcumin.	Curcumin	123-131	lysine acetyltransferase 2B	Homo sapiens	32-35
29132216-0	2017	Curcumin Decreases Hyperphosphorylation of Tau by Down-Regulating Caveolin-1/GSK-3beta in N2a/APP695swe Cells and APP/PS1 Double Transgenic Alzheimer"s Disease Mice.	Curcumin	0-8	glycogen synthase kinase 3 alpha	Mus musculus	77-86
28222524-7	2017	In addition, curcumin effect, as a selective COX-2 expression inhibitor, was detected in a time course manner.	Curcumin	13-21	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	45-50
28222524-10	2017	APE1 was significantly induced by resveratrol-curcumin combination.	Curcumin	46-54	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	0-4
27766504-8	2016	CONCLUSION: Our results show that curcumin pretreatment decreased the expression of alpha smooth muscle actin (alpha-SMA), matrix metalloproteinases-9 (MMP-9) and changed the expression of tissue inhibitors of metalloproteinase (TIMP-1) after PQ intoxication.	Curcumin	34-42	matrix metallopeptidase 9	Mus musculus	123-150
27766504-8	2016	CONCLUSION: Our results show that curcumin pretreatment decreased the expression of alpha smooth muscle actin (alpha-SMA), matrix metalloproteinases-9 (MMP-9) and changed the expression of tissue inhibitors of metalloproteinase (TIMP-1) after PQ intoxication.	Curcumin	34-42	matrix metallopeptidase 9	Mus musculus	152-157
28105206-0	2016	Curcumin enhances temsirolimus-induced apoptosis in human renal carcinoma cells through upregulation of YAP/p53.	Curcumin	0-8	Yes1 associated transcriptional regulator	Homo sapiens	104-107
28105206-6	2016	Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells.	Curcumin	13-21	Yes1 associated transcriptional regulator	Homo sapiens	61-83
28105206-6	2016	Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells.	Curcumin	13-21	Yes1 associated transcriptional regulator	Homo sapiens	85-88
28105206-6	2016	Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells.	Curcumin	13-21	Yes1 associated transcriptional regulator	Homo sapiens	239-242
28105206-6	2016	Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells.	Curcumin	159-167	Yes1 associated transcriptional regulator	Homo sapiens	85-88
28105206-6	2016	Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells.	Curcumin	159-167	Yes1 associated transcriptional regulator	Homo sapiens	239-242
28105206-6	2016	Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells.	Curcumin	159-167	Yes1 associated transcriptional regulator	Homo sapiens	85-88
28105206-6	2016	Furthermore, curcumin treatment was demonstrated to increase Yes-associated protein (YAP) expression in a time-dependent manner, which was concurrent with the curcumin-induced expression pattern of p53 after 2 h. In addition, knockdown of YAP by small interfering RNA caused the attenuation of curcumin-induced increased p53 expression in RCC cells.	Curcumin	159-167	Yes1 associated transcriptional regulator	Homo sapiens	239-242
28105206-8	2016	Mechanistically, YAP is essential in the induction of p53 expression by curcumin.	Curcumin	72-80	Yes1 associated transcriptional regulator	Homo sapiens	17-20
26317696-8	2015	Bnip3-TG mice underwent age-dependent ventricular dilation and heart failure that was partially prevented by p300 inhibition with curcumin.	Curcumin	130-138	BCL2/adenovirus E1B interacting protein 3	Mus musculus	0-5
27916071-10	2016	In 12.5, 25, 50 mumol/L curcumin+LPS groups, the p65 protein were (0.31+-0.07) , (0.75+-0.14) , (0.49+-0.08) .	Curcumin	24-32	RELA proto-oncogene, NF-kB subunit	Homo sapiens	49-52
27916071-11	2016	Compared with the LPS group, p65 was down-regulated by curcumin, with statistically significant difference (P&lt;0.05).	Curcumin	55-63	RELA proto-oncogene, NF-kB subunit	Homo sapiens	29-32
25649257-6	2015	Lower concentrations of curcumin, (-)-epigallocatechin-3-gallate (EGCG) and resveratrol upregulated UBE1L, while high concentrations of curcumin, EGCG and resveratrol downregulated UBE1L levels.	Curcumin	24-32	ubiquitin like modifier activating enzyme 7	Homo sapiens	100-105
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	7-15	transcription factor EB	Homo sapiens	61-65
25649257-6	2015	Lower concentrations of curcumin, (-)-epigallocatechin-3-gallate (EGCG) and resveratrol upregulated UBE1L, while high concentrations of curcumin, EGCG and resveratrol downregulated UBE1L levels.	Curcumin	24-32	ubiquitin like modifier activating enzyme 7	Homo sapiens	181-186
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	7-15	transcription factor EB	Homo sapiens	233-237
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	7-15	transcription factor EB	Homo sapiens	233-237
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	7-15	transcription factor EB	Homo sapiens	233-237
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	206-214	transcription factor EB	Homo sapiens	61-65
24694040-3	2015	This study was designed to evaluate the effects of sulfite and curcumin on the medial prefrontal cortex (mPFC) using stereological methods.	Curcumin	63-71	complement factor properdin	Mus musculus	105-109
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	206-214	transcription factor EB	Homo sapiens	233-237
25981383-0	2015	Curcumin Reactivates Silenced Tumor Suppressor Gene RARbeta by Reducing DNA Methylation.	Curcumin	0-8	retinoic acid receptor, beta	Mus musculus	52-59
25981383-6	2015	Herein, we demonstrated that curcumin significantly elevate RARbeta expression at the mRNA and protein levels in tested cancer cells.	Curcumin	29-37	retinoic acid receptor, beta	Mus musculus	60-67
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	206-214	transcription factor EB	Homo sapiens	233-237
25981383-11	2015	As the results from in vitro, RARbeta mRNA were increased and DNMT3b mRNA were decreased by curcumin treatment compared with the mice in control group.	Curcumin	92-100	retinoic acid receptor, beta	Mus musculus	30-37
25981383-12	2015	Altogether, this study reveals a novel molecular mechanism of curcumin as a chemo-preventive agent for lung cancer through reactivation of RARbeta.	Curcumin	62-70	retinoic acid receptor, beta	Mus musculus	139-146
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	206-214	transcription factor EB	Homo sapiens	233-237
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	206-214	transcription factor EB	Homo sapiens	61-65
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	206-214	transcription factor EB	Homo sapiens	233-237
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	206-214	transcription factor EB	Homo sapiens	233-237
26124332-7	2015	Curcumin also increased phosphorylation of p53 and Histone H2A.X (S140) in the nuclei of NCI-H460 cells.	Curcumin	0-8	H2A.X variant histone	Homo sapiens	51-64
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	206-214	transcription factor EB	Homo sapiens	233-237
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	206-214	transcription factor EB	Homo sapiens	61-65
25874494-6	2015	Downregulation of lymphatic vessel endothelial receptor 1 (LYVE-1), Prox-1, podoplanin, and VEGFR-3 mRNA expression by curcumin was also detected (all P &lt; 0.05).	Curcumin	119-127	prospero homeobox 1	Homo sapiens	68-74
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	206-214	transcription factor EB	Homo sapiens	233-237
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	206-214	transcription factor EB	Homo sapiens	233-237
26309628-8	2015	As expected, curcumin inhibited IL-22 induced phosphorylation of STAT3; furthermore, curcumin down regulated cyclin D1 and cyclin E. We can reach a conclusion that curcumin can suppress the proliferation of keratinocytes even with IL-22 treatment.	Curcumin	13-21	cyclin D1	Homo sapiens	109-118
27689333-8	2016	Third, Curcumin treatment activates transcription factor EB (TFEB), a key nuclear transcription factor in control of autophagy and lysosome biogenesis and function, based on the following observations: (i) Curcumin directly binds to TFEB, (ii) Curcumin promotes TFEB nuclear translocation; and (iii) Curcumin increases transcriptional activity of TFEB.	Curcumin	206-214	transcription factor EB	Homo sapiens	233-237
27832139-8	2016	In summary, curcumin treatment might produce a P73-dependent apoptotic cell death in chronic myelogenous leukemia cells (K562), which was triggered by mitotic catastrophe, due to sustained BAX and survivin expression and impairment of the anti-apoptotic proteins BCL-2 and XIAP.	Curcumin	12-20	tumor protein p73	Homo sapiens	47-50
27853364-3	2016	OBJECTIVE: To investigate the effect of histone modification on the expression of chemokines in type II alveolar epithelial cells (AEC II) in a rat COPD model and regulation of HDAC2 expression by curcumin in comparison with corticosteroid.	Curcumin	197-205	histone deacetylase 2	Rattus norvegicus	177-182
26309628-8	2015	As expected, curcumin inhibited IL-22 induced phosphorylation of STAT3; furthermore, curcumin down regulated cyclin D1 and cyclin E. We can reach a conclusion that curcumin can suppress the proliferation of keratinocytes even with IL-22 treatment.	Curcumin	85-93	cyclin D1	Homo sapiens	109-118
26309628-8	2015	As expected, curcumin inhibited IL-22 induced phosphorylation of STAT3; furthermore, curcumin down regulated cyclin D1 and cyclin E. We can reach a conclusion that curcumin can suppress the proliferation of keratinocytes even with IL-22 treatment.	Curcumin	85-93	cyclin D1	Homo sapiens	109-118
26048285-7	2015	Curcumin restored the brain ZO-1, JAMC, claudin 4 and claudin 5 levels (p &lt; 0.001) under hypoxia.	Curcumin	0-8	claudin 5	Rattus norvegicus	54-63
26212257-5	2015	Resveratrol+curcumin combination caused apoptosis by increasing Bax/Bcl-xL ratio, Cytochrome C release, cleaved product of PARP and caspase 3 in cells.	Curcumin	12-20	BCL2-like 1	Mus musculus	68-74
26094054-0	2015	The inhibitory mechanism by curcumin on the Zac1-enhanced cyclin D1 expression in human keratinocytes.	Curcumin	28-36	cyclin D1	Homo sapiens	58-67
26094054-3	2015	OBJECTIVES: Since cyclin D1 is a positive regulator for cell-cycle progression and its expression can be inhibited by curcumin, we would like to test whether the expression of cyclin D1 can be affected by Zac1.	Curcumin	118-126	cyclin D1	Homo sapiens	18-27
26094054-4	2015	The cross-talk between curcumin and Zac1 upon the regulation of cyclin D1 expression will also be explored in the HaCaT cell line.	Curcumin	23-31	cyclin D1	Homo sapiens	64-73
27853364-14	2016	Moreover, curcumin restored HDAC2 expression, decreased the levels of H3/H4 acetylation, and increased H3K9 methylation in the promoter region of chemokine in the presence or absence of dexamethasone (all P&lt;0.05).	Curcumin	10-18	histone deacetylase 2	Rattus norvegicus	28-33
26094054-7	2015	RESULTS: Zac1 enhances the expression of cyclin D1, but curcumin decreases both the expression of Zac1 and cyclin D1.	Curcumin	56-64	cyclin D1	Homo sapiens	107-116
26094054-8	2015	Interestingly, Zac1-induced cyclin D1 promoter activity is abolished by curcumin.	Curcumin	72-80	cyclin D1	Homo sapiens	28-37
25632966-7	2015	Further, treatment of curcumin and resveratrol to BP-treated mice significantly elevated the activities of SOD, GR, and GST.	Curcumin	22-30	glutathione reductase	Mus musculus	112-114
27853364-15	2016	CONCLUSION: Curcumin may suppress chemokines and restore corticosteroid resistance in COPD through modulating HDAC2 expression and its effect on histone modification.	Curcumin	12-20	histone deacetylase 2	Rattus norvegicus	110-115
26094054-11	2015	The experimental results implied that curcumin may inhibit the expression of ZAC, consequently down-regulate the cyclin D1 expression and decelerate cell-cycle progression of psoriatic keratinocytes.	Curcumin	38-46	cyclin D1	Homo sapiens	113-122
26827544-8	2015	On the other hand, curcumin could promote the expression of PTEN, GSK3beta and Caspase 3 yet reduce the expression of Akt.	Curcumin	19-27	glycogen synthase kinase 3 beta	Homo sapiens	66-74
27895783-10	2016	Furthermore, curcumin decreased the level of the p65 subunit of NF-kappaB binding to the promoter of the gene encoding uPA and MMP9, which suppressed transcriptional activation of uPA and MMP9.	Curcumin	13-21	RELA proto-oncogene, NF-kB subunit	Homo sapiens	49-73
26827544-9	2015	CONCLUSION: Curcumin could obviously up-regulate the expression of PTEN, GSK3beta and Caspase 3, surpress PI3K/Akt signaling pathway and hence inhibit the proliferation of Ec109 cells.	Curcumin	12-20	glycogen synthase kinase 3 beta	Homo sapiens	73-95
26261622-12	2015	Application of curcumin can inhibit expression of MMP-9, CD40L, TNF-alpha and CRP to improve the permeability of coronary artery.	Curcumin	15-23	CD40 ligand	Rattus norvegicus	57-62
25847862-10	2015	Treatment with curcumin downregulated the expression of Bcl-2, and elevated the phosphorylation level of IP3R in a concentration-dependent manner.	Curcumin	15-23	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	105-109
25847862-12	2015	In conclusion, the cytotoxic effects of curcumin on lung cancer cells were induced by calcium overload, which involves Bcl-2 mediated IP3R phosphorylation.	Curcumin	40-48	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	134-138
27777559-7	2016	Curcumin also markedly inhibited the upregulation of toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), phosphorylation level of IkappaB-alpha, and activation of NF-kappaB in PMA-induced macrophages.	Curcumin	0-8	MYD88 innate immune signal transduction adaptor	Homo sapiens	82-115
25891482-7	2015	In in vitro cell culture experiments, the 100-nm curcumin lipid nanoemulsion showed the most prominent inhibitory effect on the production of tumor necrosis factor-alpha (TNF-alpha) induced by lipopolysaccharide (LPS) in RAW264.7 murine macrophages, and on the release of beta-hexosaminidase induced by the calcium ionophore, A23187, in rat basophilic leukemia RBL-2H3 cells.	Curcumin	49-57	O-GlcNAcase	Mus musculus	272-291
26254223-0	2015	Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway.	Curcumin	0-8	kinase insert domain protein receptor	Mus musculus	137-143
26254223-2	2015	Here, we aim to test whether curcumin affects VEGF-VEGFR2 signaling pathway and attenuates defective hematopoiesis induced by VEGF in tumor model.	Curcumin	29-37	kinase insert domain protein receptor	Mus musculus	51-57
26254223-3	2015	We demonstrated that curcumin inhibited proliferation, migration of HUVEC under VEGF stimulation and caused HUVEC apoptosis, and blocked VEGFR2 activation and its downstream signaling pathways in vitro.	Curcumin	21-29	kinase insert domain protein receptor	Mus musculus	137-143
26305715-0	2015	Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes.	Curcumin	0-8	nuclear receptor subfamily 1 group H member 4	Homo sapiens	78-81
27777559-7	2016	Curcumin also markedly inhibited the upregulation of toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), phosphorylation level of IkappaB-alpha, and activation of NF-kappaB in PMA-induced macrophages.	Curcumin	0-8	MYD88 innate immune signal transduction adaptor	Homo sapiens	117-122
27777559-11	2016	Conclusion: Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA-induced macrophages.	Curcumin	12-20	MYD88 innate immune signal transduction adaptor	Homo sapiens	75-80
27497194-8	2016	Notably, curcumin inhibited the expression level of immune suppressive factors of MDSCs, arginase-1 (Arg-1) and ROS, in purified MDSCs from tumor tissue in vivo.	Curcumin	9-17	arginase, liver	Mus musculus	89-99
25846484-6	2015	Nanocurcumin ameliorated hypoxia-induced hypertrophy and apoptosis in H9c2 cells significantly (p &lt;= 0.01), by downregulating atrial natriuretic factor expression, caspase-3/-7 activation, oxidative stress and stabilizing hypoxia-inducible factor-1alpha (HIF-1alpha) better than curcumin.	Curcumin	4-12	caspase 3	Rattus norvegicus	167-176
26305715-8	2015	Additionally, curcumin induced the expression of Nrf2 and FXR in liver, strongly implying close relationship between inhibitory effect of curcumin on hepatic steatosis and the above two genes.	Curcumin	14-22	nuclear receptor subfamily 1 group H member 4	Homo sapiens	58-61
27497194-8	2016	Notably, curcumin inhibited the expression level of immune suppressive factors of MDSCs, arginase-1 (Arg-1) and ROS, in purified MDSCs from tumor tissue in vivo.	Curcumin	9-17	arginase, liver	Mus musculus	101-106
26305715-8	2015	Additionally, curcumin induced the expression of Nrf2 and FXR in liver, strongly implying close relationship between inhibitory effect of curcumin on hepatic steatosis and the above two genes.	Curcumin	138-146	nuclear receptor subfamily 1 group H member 4	Homo sapiens	58-61
27423629-6	2016	Our data also showed that curcumin inhibits oxidative stress-induced cytoskeleton disarrangement, and impedes the activation of astrocytes by inhibiting upregulation of GFAP, vimentin and Prdx6.	Curcumin	26-34	peroxiredoxin 6	Homo sapiens	188-193
26305715-10	2015	Gain- or loss-of-function analyses revealed Nrf2 and FXR mediated the effect of curcumin on lipid deposition in hepatocytes, and curcumin modulated the expression of FXR mediated by Nrf2.	Curcumin	80-88	nuclear receptor subfamily 1 group H member 4	Homo sapiens	53-56
25944087-3	2015	Curcumin increased interleukin-4 (IL-4) and interleukin-13 (IL-13) mRNA expression and protein secretion.	Curcumin	0-8	interleukin 4	Rattus norvegicus	19-32
25944087-3	2015	Curcumin increased interleukin-4 (IL-4) and interleukin-13 (IL-13) mRNA expression and protein secretion.	Curcumin	0-8	interleukin 4	Rattus norvegicus	34-38
25944087-5	2015	Leflunomide, a STAT6 inhibitor, and IL-4 and/or IL-13 neutralizing antibodies antagonized the induction of MMR, Arg-1 and PPAR-gamma by curcumin in Raw264.7 cells.	Curcumin	136-144	signal transducer and activator of transcription 6	Mus musculus	15-20
25944087-5	2015	Leflunomide, a STAT6 inhibitor, and IL-4 and/or IL-13 neutralizing antibodies antagonized the induction of MMR, Arg-1 and PPAR-gamma by curcumin in Raw264.7 cells.	Curcumin	136-144	arginase, liver	Mus musculus	112-117
25944087-5	2015	Leflunomide, a STAT6 inhibitor, and IL-4 and/or IL-13 neutralizing antibodies antagonized the induction of MMR, Arg-1 and PPAR-gamma by curcumin in Raw264.7 cells.	Curcumin	136-144	peroxisome proliferator activated receptor gamma	Mus musculus	122-132
25944087-9	2015	Meanwhile, the myocardial mRNA levels of MMR and Arg-1 were markedly up-regulated by curcumin.	Curcumin	85-93	arginase 1	Rattus norvegicus	49-54
26108778-7	2015	Compared to simple radiotherapy group, LIG4 and PNKP expression was down-regulated, and XRCC5 and CCNH expression was up-regulated in the curcumin combined with radiotherapy group (all P&lt;0.05).	Curcumin	138-146	X-ray repair cross complementing 5	Homo sapiens	88-93
26108778-7	2015	Compared to simple radiotherapy group, LIG4 and PNKP expression was down-regulated, and XRCC5 and CCNH expression was up-regulated in the curcumin combined with radiotherapy group (all P&lt;0.05).	Curcumin	138-146	cyclin H	Homo sapiens	98-102
26108778-8	2015	Western blotting revealed LIG4 and PNKP protein expression decreased, and XRCC5 and CCNH protein expression increased in the curcumin combined with radiotherapy group as compared to the simple radiotherapy group (all P&lt;0.05).	Curcumin	125-133	X-ray repair cross complementing 5	Homo sapiens	74-79
26108778-8	2015	Western blotting revealed LIG4 and PNKP protein expression decreased, and XRCC5 and CCNH protein expression increased in the curcumin combined with radiotherapy group as compared to the simple radiotherapy group (all P&lt;0.05).	Curcumin	125-133	cyclin H	Homo sapiens	84-88
26108778-9	2015	CONCLUSION: Radiation sensitization effect of curcumin on colorectal cancer cells HT-29 may be associated with the regulation of genes of CCNH, LIG4, XRCC5, PNKP.	Curcumin	46-54	cyclin H	Homo sapiens	138-142
26108778-9	2015	CONCLUSION: Radiation sensitization effect of curcumin on colorectal cancer cells HT-29 may be associated with the regulation of genes of CCNH, LIG4, XRCC5, PNKP.	Curcumin	46-54	X-ray repair cross complementing 5	Homo sapiens	150-155
25944087-10	2015	Immunofluorescence assay showed that the number of CD68(+) MMR(+) and CD68(+) Arg-1(+) double positive macrophages in curcumin-treated myocardial tissue was significantly higher than untreated control.	Curcumin	118-126	Cd68 molecule	Rattus norvegicus	51-55
25944087-10	2015	Immunofluorescence assay showed that the number of CD68(+) MMR(+) and CD68(+) Arg-1(+) double positive macrophages in curcumin-treated myocardial tissue was significantly higher than untreated control.	Curcumin	118-126	Cd68 molecule	Rattus norvegicus	70-74
25944087-10	2015	Immunofluorescence assay showed that the number of CD68(+) MMR(+) and CD68(+) Arg-1(+) double positive macrophages in curcumin-treated myocardial tissue was significantly higher than untreated control.	Curcumin	118-126	arginase 1	Rattus norvegicus	78-83
25944087-11	2015	The number of CD68(+) iNOS(+) double positive macrophages was increased obviously in EAM group, but decreased markedly by curcumin treatment.	Curcumin	122-130	Cd68 molecule	Rattus norvegicus	14-18
27572503-12	2016	Curcumin and NAC were able to inhibit H2O2-induced ROS production, reduce the migration and invasion, and decrease the expression of MMP-2 and MMP-9 in pancreatic cancer cells.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	133-138
25944087-12	2015	CONCLUSIONS: Taken together, these results show that curcumin induces macrophage M2 polarization by secretion of IL-4 and/or IL-13.	Curcumin	53-61	interleukin 4	Rattus norvegicus	113-117
26314434-4	2015	The effect of curcumin on distribution of NF-kappaB P65 subunit was analyzed by immunofluorescence and Western blot.	Curcumin	14-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	42-55
26942057-3	2016	Cryoablation involves killing of tumor cells through freezing and thawing, resulting in recruitment of tumor-specific T cells, while curcumin stimulates T cells through the reduction of IL-6 in the TME.	Curcumin	133-141	T-associated maternal effect	Mus musculus	198-201
26314434-6	2015	Western blotting showed that curcumin led to significant down-regulation of NF-kappaB P65 nuclear protein expression.	Curcumin	29-37	RELA proto-oncogene, NF-kB subunit	Homo sapiens	76-89
26314434-7	2015	Immunofluorescence assay showed that treatment with 40 micromol/L of curcumin for 48h suppressed the nuclear translocation of NF-kappaB p65 in KG1a and Kasumi-1 cells.	Curcumin	69-77	RELA proto-oncogene, NF-kB subunit	Homo sapiens	136-139
27172265-0	2016	A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.	Curcumin	8-16	transcription factor EB	Homo sapiens	47-51
26314434-8	2015	CONCLUSION: The curcumin suppresses cell growth of KG1a and Kasumi-1 cells, its mechanism may be related to inhibitory effect of curcumin on NF-kappaB p65 nucleus protein.	Curcumin	16-24	RELA proto-oncogene, NF-kB subunit	Homo sapiens	151-154
27172265-5	2016	In this study, a synthesized curcumin derivative termed C1 is identified as a novel MTOR-independent activator of TFEB.	Curcumin	29-37	transcription factor EB	Homo sapiens	114-118
26314434-8	2015	CONCLUSION: The curcumin suppresses cell growth of KG1a and Kasumi-1 cells, its mechanism may be related to inhibitory effect of curcumin on NF-kappaB p65 nucleus protein.	Curcumin	129-137	RELA proto-oncogene, NF-kB subunit	Homo sapiens	151-154
26081871-0	2016	Promoter methylation-independent reactivation of PAX1 by curcumin and resveratrol is mediated by UHRF1.	Curcumin	57-65	paired box 1	Homo sapiens	49-53
25755051-0	2015	Curcumin induces apoptotic cell death via Oct4 inhibition and GSK-3beta activation in NCCIT cells.	Curcumin	0-8	glycogen synthase kinase 3 beta	Homo sapiens	62-71
25988362-6	2015	Furthermore, such a curcumin treatment reduced CFA-induced activation of glial cells and production of inflammatory mediators [interleukin-1beta (IL-1beta), monocyte chemoattractant protein-1 (MCP-1), and monocyte inflammatory protein-1 (MIP-1alpha)] in the spinal cord.	Curcumin	20-28	C-C motif chemokine ligand 3	Rattus norvegicus	238-248
25988362-7	2015	Curcumin also decreased lipopolysaccharide-induced production of IL-1beta, tumor necrosis factor-alpha, MCP-1, and MIP-1alpha in cultured astrocytes and microglia.	Curcumin	0-8	C-C motif chemokine ligand 3	Rattus norvegicus	115-125
25971429-0	2015	Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-kappaB/p65 and MUC1-C. BACKGROUND: Prostate cancer is one of the most common malignancies in men.	Curcumin	15-23	RELA proto-oncogene, NF-kB subunit	Homo sapiens	179-182
25971429-0	2015	Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-kappaB/p65 and MUC1-C. BACKGROUND: Prostate cancer is one of the most common malignancies in men.	Curcumin	15-23	mucin 1, cell surface associated	Homo sapiens	187-191
26081871-3	2016	Curcumin in HeLa and SiHa cells and resveratrol in Caski cells caused significant (P &lt; 0.01) reactivation of PAX1 expression as shown by qRT PCR, but reversal of promoter hypermethylation was not observed across the three cell lines.	Curcumin	0-8	paired box 1	Homo sapiens	112-116
25971429-8	2015	In addition, curcumin reduced the protein expression of MUC1-C and NF-kappaB subunit p65, which were abrogated in the presence of the inhibitors of MEK/ERK1/2 (PD98059) and SAPK/JNK (SP60015).	Curcumin	13-21	mucin 1, cell surface associated	Homo sapiens	56-60
25971429-8	2015	In addition, curcumin reduced the protein expression of MUC1-C and NF-kappaB subunit p65, which were abrogated in the presence of the inhibitors of MEK/ERK1/2 (PD98059) and SAPK/JNK (SP60015).	Curcumin	13-21	RELA proto-oncogene, NF-kB subunit	Homo sapiens	85-88
25961579-11	2015	To further understand whether NF-kB is involved in this inhibition, we examined the effect of curcumin on the expression of p50 and p65 subunits of NF-kB in decidual cells.	Curcumin	94-102	RELA proto-oncogene, NF-kB subunit	Homo sapiens	132-135
25961579-13	2015	However, curcumin treatment dramatically inhibited both p50 and p65 protein levels and prevented its nuclear localization.	Curcumin	9-17	RELA proto-oncogene, NF-kB subunit	Homo sapiens	64-67
26081871-5	2016	However, a striking correlation between PAX1 reactivation and Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) downregulation after treatment with curcumin and resveratrol in HeLa, SiHa and Caski cell lines was observed which was further confirmed after transient silencing of UHRF1 expression.	Curcumin	156-164	paired box 1	Homo sapiens	40-44
26081871-6	2016	PAX1 reexpression was also obtained in Caski and SiHa cell lines after treatment with sodium butyrate, a histone deacetylase inhibitor, suggesting that PAX1 reactivation by curcumin and resveratrol may be due to their effect on histone deacetylase mediated through downregulation of UHRF1 which can regulate both DNA methylation and histone acetylation.	Curcumin	173-181	paired box 1	Homo sapiens	0-4
25910231-3	2015	In the current manuscript, we investigated the mechanism of curcumin-induced apoptosis in upper aerodigestive tract cancer cell lines and showed that curcumin-induced apoptosis is mediated by the modulation of multiple pathways such as induction of p73, and inhibition of p-AKT and Bcl-2.	Curcumin	150-158	tumor protein p73	Homo sapiens	249-252
25910231-4	2015	Treatment of cells with curcumin induced both p53 and the related protein p73 in head and neck and lung cancer cell lines.	Curcumin	24-32	tumor protein p73	Homo sapiens	74-77
26081871-6	2016	PAX1 reexpression was also obtained in Caski and SiHa cell lines after treatment with sodium butyrate, a histone deacetylase inhibitor, suggesting that PAX1 reactivation by curcumin and resveratrol may be due to their effect on histone deacetylase mediated through downregulation of UHRF1 which can regulate both DNA methylation and histone acetylation.	Curcumin	173-181	paired box 1	Homo sapiens	152-156
25910231-5	2015	Inactivation of p73 by dominant negative p73 significantly protected cells from curcumin-induced apoptosis, whereas ablation of p53 by shRNA had no effect.	Curcumin	80-88	tumor protein p73	Homo sapiens	16-19
27446282-6	2016	However, the increased HSF-1 level was downregulated by curcumin.	Curcumin	56-64	heat shock factor 1	Mus musculus	23-28
25910231-5	2015	Inactivation of p73 by dominant negative p73 significantly protected cells from curcumin-induced apoptosis, whereas ablation of p53 by shRNA had no effect.	Curcumin	80-88	tumor protein p73	Homo sapiens	41-44
25910231-7	2015	Taken together, our findings suggest that curcumin-induced apoptosis is mediated via activating tumor suppressor p73 and inhibiting p-AKT and Bcl-2.	Curcumin	42-50	tumor protein p73	Homo sapiens	113-116
26134921-0	2016	Curcumin induces apoptosis and suppresses invasion through MAPK and MMP signaling in human monocytic leukemia SHI-1 cells.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	68-71
25960232-7	2015	Atg7 silencing further increased apoptotic potential of curcumin in the presence or absence of LY294002 in wt and Bcl-2+ MCF-7 cells.	Curcumin	56-64	autophagy related 7	Homo sapiens	0-4
26134921-8	2016	Additionally, curcumin partially suppressed SHI-1 cell invasion and attenuated the mRNA transcription and secretion of MMP-2 and MMP-9.	Curcumin	14-22	matrix metallopeptidase 2	Homo sapiens	119-124
24926560-7	2015	The results indicate that curcumin increased the cell surface expression of CD35 (secretory vesicle), CD63 (azurophilic granules), and CD66b (gelatinase granules) in neutrophils.	Curcumin	26-34	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	76-80
26134921-9	2016	DISCUSSION AND CONCLUSION: This study demonstrates that curcumin not only induces SHI-1 cell apoptosis, possibly via both intrinsic and extrinsic pathways triggered by JNK, P38 MAPK and ERK signaling, but also partially suppresses SHI-1 cell invasion, likely by reducing the levels of transcription and secretion of MMP-2 and MMP-9.	Curcumin	56-64	matrix metallopeptidase 2	Homo sapiens	316-321
25502175-4	2015	Furthermore, the present study investigated the effect of curcumin and its metabolites on the expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) and activated-nuclear factor kappa B (NF-kappaB); the results showed that curcumin and its three metabolites significantly inhibited LPS-mediated upregulation of iNOS and COX-2 as well as NF-kappaB activation.	Curcumin	58-66	prostaglandin-endoperoxide synthase 2	Mus musculus	138-154
25502175-4	2015	Furthermore, the present study investigated the effect of curcumin and its metabolites on the expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2) and activated-nuclear factor kappa B (NF-kappaB); the results showed that curcumin and its three metabolites significantly inhibited LPS-mediated upregulation of iNOS and COX-2 as well as NF-kappaB activation.	Curcumin	58-66	prostaglandin-endoperoxide synthase 2	Mus musculus	156-161
27407064-0	2016	Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer"s disease.	Curcumin	11-19	membrane metallo endopeptidase	Mus musculus	52-62
27407064-4	2016	Here, we used a sensitive fluorescence-based Abeta digestion assay to screen 25 curcumin analogs for their ability to upregulate NEP activity.	Curcumin	80-88	membrane metallo endopeptidase	Mus musculus	129-132
27407064-5	2016	To our surprise, four compounds, dihydroxylated curcumin, monohydroxylated demethoxycurcumin, and mono- and di-hydroxylated bisdemethoxycurcumin, increased NEP activity, while curcumin did not.	Curcumin	48-56	membrane metallo endopeptidase	Mus musculus	156-159
27306423-5	2016	We show that curcumin targets both stem cell populations by down-regulating expression of breast stem cell genes including ALDH1A3, CD49f, PROM1, and TP63.	Curcumin	13-21	prominin 1	Homo sapiens	139-144
25653233-10	2015	Curcumin suppressed EMT in 5FUR cells by downregulating BMI1, SUZ12 and EZH2 transcripts, key mediators of cancer stemness-related polycomb repressive complex subunits.	Curcumin	0-8	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	56-60
25653233-10	2015	Curcumin suppressed EMT in 5FUR cells by downregulating BMI1, SUZ12 and EZH2 transcripts, key mediators of cancer stemness-related polycomb repressive complex subunits.	Curcumin	0-8	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	62-67
25519685-0	2015	Curcumin ameliorate DENA-induced HCC via modulating TGF-beta, AKT, and caspase-3 expression in experimental rat model.	Curcumin	0-8	caspase 3	Rattus norvegicus	71-80
25519685-6	2015	Curcumin treatment partially reversed DENA-induced damage as it reduced the overexpression of the angiogenic and anti-apoptotic factors TGF-beta and Akt and improved caspase-3 expression.	Curcumin	0-8	caspase 3	Rattus norvegicus	166-175
26248429-10	2015	The data of FCM showed that curcumin could increase the expression of PTEN, GSK3beta and Caspase 3, decreased the expression of AKT.	Curcumin	28-36	glycogen synthase kinase 3 beta	Homo sapiens	76-98
25577709-4	2015	In this context, aiming at further exploring the mechanisms of action of our newly synthesized antioxidant compounds (AK1 and AK2) in a skeletal muscle experimental setting, we initially investigated their scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and subsequently assessed their effect on the viability of C2 skeletal myoblasts in the presence of two pro-oxidants: H2O2 and curcumin (MTT assay).	Curcumin	391-399	adenylate kinase 2	Homo sapiens	126-129
25577709-5	2015	Interestingly, while both compounds reversed the detrimental effect of H2O2, only AK2 was cytoprotective in curcumin-treated C2 cells.	Curcumin	108-116	adenylate kinase 2	Homo sapiens	82-85
25577709-7	2015	In correlation with the aforementioned results, only AK2 blocked the curcumin-induced activation of JNKs pathway.	Curcumin	69-77	adenylate kinase 2	Homo sapiens	53-56
25574201-0	2015	Curcumin protects against lipopolysaccharide-induced vasoconstriction dysfunction via inhibition of thrombospondin-1 and transforming growth factor-beta1.	Curcumin	0-8	thrombospondin 1	Rattus norvegicus	100-153
25574201-12	2015	The serum level of E-selectin and the expression levels of TSP-1 and TGF-beta1 significantly increased in the sepsis rats when compared with the control group rats; however, the levels decreased significantly following treatment with curcumin (10 or 20 mg/kg).	Curcumin	234-242	thrombospondin 1	Rattus norvegicus	59-64
25499851-7	2015	MnSOD-mediated cisplatin resistance can be overcome by a Bcl-2 antagonist (ABT-199) or IKKbeta inhibitor (curcumin) in cells and xenograft tumors.	Curcumin	106-114	superoxide dismutase 2	Homo sapiens	0-5
25499851-10	2015	Therefore, we suggest that ABT-199 or curcumin may be potentially useful to improve tumor regression and chemotherapeutic response in patients with MnSOD/Bcl-2-positive tumors.	Curcumin	38-46	superoxide dismutase 2	Homo sapiens	148-153
25445048-6	2015	Our results showed that curcumin stimulation increased PGC-1alpha expression and the effects of curcumin on PGC-1alpha expression were correlated with the activation of adenosine monophosphate-activated protein kinase (AMPK).	Curcumin	24-32	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	169-217
25445048-6	2015	Our results showed that curcumin stimulation increased PGC-1alpha expression and the effects of curcumin on PGC-1alpha expression were correlated with the activation of adenosine monophosphate-activated protein kinase (AMPK).	Curcumin	24-32	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	219-223
25445048-6	2015	Our results showed that curcumin stimulation increased PGC-1alpha expression and the effects of curcumin on PGC-1alpha expression were correlated with the activation of adenosine monophosphate-activated protein kinase (AMPK).	Curcumin	96-104	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	169-217
25445048-6	2015	Our results showed that curcumin stimulation increased PGC-1alpha expression and the effects of curcumin on PGC-1alpha expression were correlated with the activation of adenosine monophosphate-activated protein kinase (AMPK).	Curcumin	96-104	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	219-223
25445048-7	2015	Curcumin increased superoxide dimutase-2 (SOD2) transcription and activity by AMPK/PGC-1alpha axis.	Curcumin	0-8	superoxide dismutase 2	Homo sapiens	42-46
25445048-7	2015	Curcumin increased superoxide dimutase-2 (SOD2) transcription and activity by AMPK/PGC-1alpha axis.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	78-82
25445048-9	2015	These results demonstrated the promotion effect of curcumin on PGC-1alpha expression through AMPK pathway, which led to the increases in PPARgamma activity and in SOD-2 transcription and activity.	Curcumin	51-59	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	93-97
25445048-9	2015	These results demonstrated the promotion effect of curcumin on PGC-1alpha expression through AMPK pathway, which led to the increases in PPARgamma activity and in SOD-2 transcription and activity.	Curcumin	51-59	superoxide dismutase 2	Homo sapiens	163-168
25459681-2	2015	Human VDAC-1, reconstituted in planar lipid bilayer showed reduced conductance when treated with curcumin.	Curcumin	97-105	voltage dependent anion channel 1	Homo sapiens	6-12
25879038-7	2015	Specifically, we showed that curcumin is able to deregulate the expression of cyclin D1, PECAM-1, and p65, which are regulated by NF-kappaB.	Curcumin	29-37	cyclin D1	Homo sapiens	78-87
25879038-7	2015	Specifically, we showed that curcumin is able to deregulate the expression of cyclin D1, PECAM-1, and p65, which are regulated by NF-kappaB.	Curcumin	29-37	platelet and endothelial cell adhesion molecule 1	Homo sapiens	89-96
25879038-7	2015	Specifically, we showed that curcumin is able to deregulate the expression of cyclin D1, PECAM-1, and p65, which are regulated by NF-kappaB.	Curcumin	29-37	RELA proto-oncogene, NF-kB subunit	Homo sapiens	102-105
25613752-10	2015	The inhibitory effect of curcumin on the differentiation and migration of human circulating fibrocytes is likely via regulating the CCR7/CCL21 signaling pathway, in particular by reducing CCR7 expression.	Curcumin	25-33	C-C motif chemokine ligand 21	Homo sapiens	137-142
25998190-9	2015	RESULTS: Curcumin dose-dependently inhibited M1 macrophage polarization and the production of TNF-alpha, IL-6, and IL-12B (p40).	Curcumin	9-17	interleukin 9	Homo sapiens	123-126
26539236-4	2015	Furthermore, the experiments in vitro and in vivo both displayed that curcumin could downregulate the mRNA and protein expressions of Wnt1, Wnt2b, Wnt6, and beta-catenin and upregulate the phosphorylation level of beta-catenin protein in podocytes and renal tissue.	Curcumin	70-78	wingless-type MMTV integration site family, member 1	Mus musculus	134-138
25262359-0	2015	Curcumin induces apoptosis through mitochondrial pathway and caspases activation in human melanoma cells.	Curcumin	0-8	caspase 8	Homo sapiens	61-69
25262359-10	2015	During curcumin treatment, caspase-8 and Caspase-3 were cleaved in time and dose-dependent manners.	Curcumin	7-15	caspase 8	Homo sapiens	27-36
25262359-12	2015	Curcumin induced DNA double strand breaks, which were indicated by phosphorylated H2AX.	Curcumin	0-8	H2A.X variant histone	Homo sapiens	82-86
26080567-9	2015	All of the three curcumin could down-regulate the expression of VEGF and ICAM-1, and curcumins showed more obvious effect in down-regulating VEGF than demethoxycurcumin and bisdemethoxycurcumin(P &lt; 0.01); Bisdemethoxycurcumin showed the most significant effect in down-regulating ICAM-1 (P &lt; 0.01).	Curcumin	17-25	vascular endothelial growth factor A	Gallus gallus	64-68
26080567-9	2015	All of the three curcumin could down-regulate the expression of VEGF and ICAM-1, and curcumins showed more obvious effect in down-regulating VEGF than demethoxycurcumin and bisdemethoxycurcumin(P &lt; 0.01); Bisdemethoxycurcumin showed the most significant effect in down-regulating ICAM-1 (P &lt; 0.01).	Curcumin	85-94	vascular endothelial growth factor A	Gallus gallus	141-145
26080567-11	2015	According to the findings, all of the three curcumin pigments could resist angiogenesis by inhibiting proliferation and migration of endothelial cells and down-regulating the expression of VEGF and adhesion molecules ICAM-1.	Curcumin	44-52	vascular endothelial growth factor A	Gallus gallus	189-193
25431425-8	2014	PGE2 inhibited curcumin-induced apoptosis by suppressing oxidative stress and degradation of PARP and lamin B.	Curcumin	15-23	collagen type XI alpha 2 chain	Homo sapiens	93-97
25628937-0	2015	Curcumin suppresses invasiveness and vasculogenic mimicry of squamous cell carcinoma of the larynx through the inhibition of JAK-2/STAT-3 signaling pathway.	Curcumin	0-8	Janus kinase 2	Homo sapiens	125-130
25628937-5	2015	Compared to control group,there were less tumor cells permeating membrane and less formed tubes after curcumin or AG490 treatment, RT-PCR showed that the expression of MMP-2 and VEGF at mRNA level were decreased (P &lt; 0.01).	Curcumin	102-110	matrix metallopeptidase 2	Homo sapiens	168-173
25217884-8	2014	Individually, curcumin was more effective than hesperidin in reducing the levels of oxidized lipids, proteins, cleaved caspase-3 expression and mitochondrial enzymes.	Curcumin	14-22	caspase 3	Rattus norvegicus	119-128
25033705-8	2014	Furthermore, cells in the IWR1-treated group showed decreased wnt3a and beta-catenin expression, and wnt3a and beta-catenin was also decreased in the IWR1 + 500 nmol/L curcumin group.	Curcumin	168-176	Wnt family member 3A	Rattus norvegicus	101-106
24619502-6	2014	In C6 cells, curcumin markedly decreased promoter II acetylation and activity and GDNF mRNA expression.	Curcumin	13-21	glial cell derived neurotrophic factor	Rattus norvegicus	82-86
25530715-0	2014	The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway.	Curcumin	92-100	S-phase kinase associated protein 2	Homo sapiens	134-138
25450696-4	2014	Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/beta-catenin signaling by increasing the expression levels of the GSK-3beta, phosphorylated GSK-3beta and beta-catenin, and decreasing the cyclin D1 level.	Curcumin	40-48	glycogen synthase kinase 3 beta	Homo sapiens	224-233
25450696-4	2014	Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/beta-catenin signaling by increasing the expression levels of the GSK-3beta, phosphorylated GSK-3beta and beta-catenin, and decreasing the cyclin D1 level.	Curcumin	40-48	glycogen synthase kinase 3 beta	Homo sapiens	250-259
25450696-4	2014	Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/beta-catenin signaling by increasing the expression levels of the GSK-3beta, phosphorylated GSK-3beta and beta-catenin, and decreasing the cyclin D1 level.	Curcumin	40-48	cyclin D1	Homo sapiens	297-306
25201174-6	2014	When curcumin decreased the acetylation level of H3K9 at the Egr-1 binding site, the binding of Egr-1 to promoter region II and GDNF mRNA levels significantly decreased.	Curcumin	5-13	glial cell derived neurotrophic factor	Rattus norvegicus	128-132
25891083-0	2015	Curcumin inhibits appoptosin-induced apoptosis via upregulating heme oxygenase-1 expression in SH-SY5Y cells.	Curcumin	0-8	solute carrier family 25 member 38	Homo sapiens	18-28
25891083-2	2015	The aim of this study was to investigate the effects of curcumin from the rhizome of Curcuma longa on appoptosin-induced apoptosis in SH-SY5Y cells.	Curcumin	56-64	solute carrier family 25 member 38	Homo sapiens	102-112
25799055-5	2015	We observed Rcan1 isoform 1 (Rcan1-1) protein reduction in mice pup hippocampus after a 4-week curcumin and fish oil supplementation, with only fish oil reduction being statistically significant.	Curcumin	95-103	regulator of calcineurin 1	Mus musculus	29-36
25856395-4	2015	Pre-treatment with curcumin prevented disruption of the mucosal barrier by maintaining ZO-1 and occludin expression and maintained trans-epithelial electric resistance across the genital epithelium.	Curcumin	19-27	occludin	Homo sapiens	96-104
25722997-1	2015	A highly porous bio-MOF, medi-MOF-1, constructed from Zn and the pharmaceutical ingredient curcumin has been successfully synthesized.	Curcumin	91-99	lysine acetyltransferase 8	Homo sapiens	20-23
25722997-1	2015	A highly porous bio-MOF, medi-MOF-1, constructed from Zn and the pharmaceutical ingredient curcumin has been successfully synthesized.	Curcumin	91-99	lysine acetyltransferase 8	Homo sapiens	30-33
25786122-6	2015	We observed that curcumin and emodin effectively down regulate TGF-beta signaling pathway by decreasing the expression of TGF-beta Receptor II, P-Smad3 and Smad4, and also counterbalance the tumorigenic effects of TGF-beta by inhibiting the TGF-beta-induced migration and invasion.	Curcumin	17-25	SMAD family member 4	Homo sapiens	156-161
25786122-7	2015	Expression of downstream effectors of TGF-beta signaling pathway, cyclinD1, p21 and Pin1, was inhibited along with the down regulation of key mesenchymal markers (Snail and Slug) upon curcumin and emodin treatment.	Curcumin	184-192	cyclin D1	Homo sapiens	66-74
25526088-2	2015	Here we show that this applies to anacardic acid, curcumin, garcinol and spermidine, all of which reduce the acetylation level of cultured human cells as they induce signs of increased autophagic flux (such as the formation of green fluorescent protein-microtubule-associated protein 1A/1B-light chain 3 (GFP-LC3) puncta and the depletion of sequestosome-1, p62/SQSTM1) coupled to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).	Curcumin	50-58	CREB regulated transcription coactivator 1	Mus musculus	444-450
25526088-6	2015	Notably, anacardic acid, curcumin, garcinol and spermidine all inhibited the acetyltransferase activity of recombinant EP300 protein in vitro.	Curcumin	25-33	E1A binding protein p300	Homo sapiens	119-124
25536420-5	2015	Apoptotic and anti-apoptotic signaling proteins, such as cleaved caspase-3 and B-cell lymphoma 2, were significantly increased and decreased, respectively in diabetic rats; curcumin treatment prevented all of these alterations.	Curcumin	173-181	caspase 3	Rattus norvegicus	65-74
24975470-5	2014	In addition, curcumin markedly increased neuronal viability, as evidenced by decreased lactate dehydrogenase release and reduced nitric oxide production, caspase-3 activity, and apoptosis.	Curcumin	13-21	caspase 3	Rattus norvegicus	154-163
25027711-2	2014	Accumulating evidence from in vitro studies has shown that curcumin is a potent inhibitor of the IGF-1 signaling pathway.	Curcumin	59-67	insulin-like growth factor 1	Mus musculus	97-102
26912222-8	2016	Curcumin inhibited TGFbeta1- and thrombin-induced CCN2 synthesis.	Curcumin	0-8	cellular communication network factor 2	Homo sapiens	50-54
27302110-13	2016	The results showed that curcumin treatment led to less macrophage infiltration and less local inflammatory responses as demonstrated by decreasing TNF-alpha, IL-1, and IL-6 levels.	Curcumin	24-32	interleukin 1 complex	Mus musculus	158-162
25027711-3	2014	However, direct evidence that curcumin modulates IGF-1-induced tumorigenesis in a physiological system has not been reported.	Curcumin	30-38	insulin-like growth factor 1	Mus musculus	49-54
27283735-11	2016	Taken together our study reveals a novel observation that curcumin causes potent degradation of Tat which may be one of the major mechanisms behind its anti HIV activity.	Curcumin	58-66	tyrosine aminotransferase	Homo sapiens	96-99
25027711-4	2014	Therefore, in this study, we assessed the anticarcinogenic activity of curcumin on skin cancer by using BK5.IGF-1 transgenic (Tg) mice that overexpress IGF-1 in the skin epidermis.	Curcumin	71-79	insulin-like growth factor 1	Mus musculus	152-157
25027711-7	2014	Curcumin treatment inhibited IGF-1-induced phosphorylation of the IGF-1 receptor, insulin receptor substrate-1, Akt, S6K, and 4EBP1 in the mouse keratinocyte cell line, C50 in a dose-dependent manner.	Curcumin	0-8	insulin-like growth factor 1	Mus musculus	29-34
25027711-7	2014	Curcumin treatment inhibited IGF-1-induced phosphorylation of the IGF-1 receptor, insulin receptor substrate-1, Akt, S6K, and 4EBP1 in the mouse keratinocyte cell line, C50 in a dose-dependent manner.	Curcumin	0-8	insulin-like growth factor 1	Mus musculus	66-71
25027711-8	2014	Taken together, these data suggest that curcumin exerts significant anticarcinogenic activity in skin cancer through the inhibition of IGF-1 signaling.	Curcumin	40-48	insulin-like growth factor 1	Mus musculus	135-140
28087906-12	2016	Conclusion: Curcumin could promote the apoptosis of smooth muscle cells in rats with COPD, and improve the mean pulmonary artery pressure and RVMI through stimulating SOCS-3/JAK2/STAT signaling pathway.	Curcumin	12-20	suppressor of cytokine signaling 3	Rattus norvegicus	167-173
25064633-9	2014	Curcumin also enhanced RCT via up-regulating the expression of liver X receptor alpha (LXRalpha), ATP-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type I (SR-BI).	Curcumin	0-8	nuclear receptor subfamily 1 group H member 3	Homo sapiens	87-95
27279695-0	2016	Kinetics of Inhibition of Monoamine Oxidase Using Curcumin and Ellagic Acid.	Curcumin	50-58	monoamine oxidase A	Rattus norvegicus	26-43
25202424-0	2014	Curcumin inhibits vasculogenic mimicry through the downregulation of erythropoietin-producing hepatocellular carcinoma-A2, phosphoinositide 3-kinase and matrix metalloproteinase-2.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	153-179
25338570-9	2014	Arsenic trioxide combined with curcumin can effectively inhibit the KG1a cell proliferation and induce apoptosis, which may be associated with the downregulation of BCL-2 and PARP protein expression and the upregulation of BAX protein expression.	Curcumin	31-39	collagen type XI alpha 2 chain	Homo sapiens	175-179
25229239-12	2014	It was found that curcumin attenuated AKT activation and the up-regulation of C/EBPbeta and miR-31 caused by EGF stimulation in OSCC cells.	Curcumin	18-26	CCAAT enhancer binding protein beta	Homo sapiens	78-87
27122821-6	2014	Curcumin-treated cardiac fibroblasts had increased matrix metalloproteinase (MMP)-2 activity in the presence of Ang II treatment.	Curcumin	0-8	matrix metallopeptidase 2	Rattus norvegicus	51-83
27122821-8	2014	Curcumin also decreased phosphorylated extracellular signal-regulated kinase (ERK)1/2 levels in the presence of Ang II.	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	39-85
27122821-9	2014	CONCLUSIONS: Curcumin attenuated Akt, Smad2/3, and ERK1/2 phosphorylation which were mediated by TGF-beta1 and angiotensin II.	Curcumin	13-21	mitogen activated protein kinase 3	Rattus norvegicus	51-57
25136316-7	2014	In addition, curcumin with its versatile activities modulated the expression of many oxidative stress-regulating genes such as PDGF, VEGF, IGFBP-2, HO1, SOD2, and GPX1.	Curcumin	13-21	insulin like growth factor binding protein 2	Homo sapiens	139-146
25136316-7	2014	In addition, curcumin with its versatile activities modulated the expression of many oxidative stress-regulating genes such as PDGF, VEGF, IGFBP-2, HO1, SOD2, and GPX1.	Curcumin	13-21	superoxide dismutase 2	Homo sapiens	153-157
24814288-10	2014	In addition, cell viability and drug pump-out ability were significantly reduced in the FZD1 inhibitor curcumin-treated and FZD1 shRNA-knockdown MES-SA/Dx5 cells, indicating involvement of PKCdelta in FZD1-modulated ABCB1 expression pathway.	Curcumin	103-111	frizzled class receptor 1	Homo sapiens	88-92
24814288-10	2014	In addition, cell viability and drug pump-out ability were significantly reduced in the FZD1 inhibitor curcumin-treated and FZD1 shRNA-knockdown MES-SA/Dx5 cells, indicating involvement of PKCdelta in FZD1-modulated ABCB1 expression pathway.	Curcumin	103-111	protein kinase C delta	Homo sapiens	189-197
24756894-0	2014	Curcumin inhibits the AKT/NF-kappaB signaling via CpG demethylation of the promoter and restoration of NEP in the N2a cell line.	Curcumin	0-8	membrane metallo endopeptidase	Mus musculus	103-106
24858998-8	2014	Furthermore, curcumin treatment led to activation of GSK-3beta, reduced expression of beta-catenin and its downstream target cyclin D1.	Curcumin	13-21	glycogen synthase kinase 3 beta	Homo sapiens	53-62
24858998-8	2014	Furthermore, curcumin treatment led to activation of GSK-3beta, reduced expression of beta-catenin and its downstream target cyclin D1.	Curcumin	13-21	cyclin D1	Homo sapiens	125-134
24668280-5	2014	Curcumin was found to activate p38-mitogen-activated protein kinase (p38-MAPK) as well as c-jun NH2 terminal kinases (JNKs), in a dose- and time-dependent manner.	Curcumin	0-8	mitogen activated protein kinase 14	Rattus norvegicus	31-67
24668280-5	2014	Curcumin was found to activate p38-mitogen-activated protein kinase (p38-MAPK) as well as c-jun NH2 terminal kinases (JNKs), in a dose- and time-dependent manner.	Curcumin	0-8	mitogen activated protein kinase 14	Rattus norvegicus	69-77
24668280-6	2014	We also observed curcumin to impair cell survival by promoting apoptosis, evidenced by chromatin condensation, poly(ADP-ribose) polymerase (PARP) and caspase-3 cleavage, as well as Bax translocation and cytochrome c release into the cytosol.	Curcumin	17-25	caspase 3	Rattus norvegicus	150-159
24641259-9	2014	Furthermore, amitriptyline-induced Cx43 expression and GJIC were markedly reduced by transcription factor AP-1 inhibitors (curcumin and tanshinone IIA).	Curcumin	123-131	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	106-110
24926361-0	2014	Curcumin suppresses tumor necrosis factor-alpha-induced matrix metalloproteinase-2 expression and activity in rat vascular smooth muscle cells via the NF-kappaB pathway.	Curcumin	0-8	matrix metallopeptidase 2	Rattus norvegicus	56-82
23192861-4	2014	Curcumin suppressed SDF-1alpha-induced cell invasion and matrix metalloproteinase-2 (MMP-2) promoter activity, cell surface localization of CXCR4 at lipid rafts, and lipid raft-associated ras-related C3 botulinum toxin substrate 1 (Rac1)/phosphatidylinositol 3-kinase (PI3K) p85alpha/Akt signaling.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	57-83
23192861-4	2014	Curcumin suppressed SDF-1alpha-induced cell invasion and matrix metalloproteinase-2 (MMP-2) promoter activity, cell surface localization of CXCR4 at lipid rafts, and lipid raft-associated ras-related C3 botulinum toxin substrate 1 (Rac1)/phosphatidylinositol 3-kinase (PI3K) p85alpha/Akt signaling.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	85-90
23192861-6	2014	We further demonstrate that the attenuation of lipid raft-associated Rac1 activity by curcumin was critical for the inhibition of SDF-1alpha-induced PI3K/Akt/NF-kappaB activation, cell surface localization of CXCR4 at lipid rafts, MMP-2 promoter activity, and cell invasion.	Curcumin	86-94	matrix metallopeptidase 2	Homo sapiens	231-236
23192861-7	2014	Collectively, our results indicate that curcumin inhibits SDF-1alpha-induced EC cell invasion by suppressing the formation of the lipid raft-associated Rac1-PI3K-Akt signaling complex, the localization of CXCR4 with lipid rafts at the cell surface, and MMP-2 promoter activity, likely through the inhibition of Rac1 activity.	Curcumin	40-48	matrix metallopeptidase 2	Homo sapiens	253-258
24508477-9	2014	Both curcumin and EGCG effectively reduced acrylamide-induced proliferation, as well as protein expression of CYP2E1, EGFR, cyclin D1 and NF-kappaB.	Curcumin	5-13	cyclin D1	Homo sapiens	124-133
24669820-15	2014	CONCLUSIONS: Our results suggest that post-injury, curcumin administration may improve patient outcome by reducing acute activation of microglia/macrophages and neuronal apoptosis through a mechanism involving the TLR4/MyD88/NF-kappaB signaling pathway in microglia/macrophages in TBI.	Curcumin	51-59	MYD88 innate immune signal transduction adaptor	Homo sapiens	219-224
24252336-4	2014	The expression of TEM-1 beta-lactamase enzyme was increased in the presence of ssDNA induced by levofloxacin, while, the presence of curcumin at 8mug/ml, reduced dramatically the expression of the reporter gene.	Curcumin	133-141	TEM-1 beta-lactamase	Escherichia coli	18-38
24603592-0	2014	Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	128-133
24603592-8	2014	Chromatin immunoprecipitation analysis revealed that curcumin dose-dependently reduced the recruitment of p300/CBP and acetyl-Histone H3/acetyl-Histone H4 to the promoter of BDNF and Cox-2 genes.	Curcumin	53-61	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	183-188
24603592-9	2014	A similar dose-dependent decrease of BDNF and Cox-2 in the spinal cord was also observed after curcumin treatment.	Curcumin	95-103	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	46-51
24603592-10	2014	These results indicated that curcumin exerted a therapeutic role in neuropathic pain by down-regulating p300/CBP HAT activity-mediated gene expression of BDNF and Cox-2.	Curcumin	29-37	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	163-168
24431405-5	2014	Using in vitro models with mouse and human malignant mesothelioma cells, curcumin is shown to induce pyroptosis through activation of caspase-1 and increased release of high-mobility group box 1 (HMGB1) without processing of IL-1beta and IL-18.	Curcumin	73-81	high mobility group box 1	Homo sapiens	169-194
24431405-5	2014	Using in vitro models with mouse and human malignant mesothelioma cells, curcumin is shown to induce pyroptosis through activation of caspase-1 and increased release of high-mobility group box 1 (HMGB1) without processing of IL-1beta and IL-18.	Curcumin	73-81	high mobility group box 1	Homo sapiens	196-201
24520264-9	2014	Curcumin and puerarin significantly increased the levels of peroxisome proliferator-activated receptor-gamma (PPARgamma; P&lt;0.05, versus the MCD group).	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	60-108
24520264-9	2014	Curcumin and puerarin significantly increased the levels of peroxisome proliferator-activated receptor-gamma (PPARgamma; P&lt;0.05, versus the MCD group).	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	110-119
24402549-0	2014	Differential expression and regulation of prohibitin during curcumin-induced apoptosis of immortalized human epidermal HaCaT cells.	Curcumin	60-68	prohibitin 1	Homo sapiens	42-52
24402549-5	2014	The western blot analysis results revealed that PHB exists in the composition of nuclear matrix proteins and that the expression level of PHB is significantly increased in the whole cell and markedly decreased in the nuclear matrix after curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) treatment.	Curcumin	238-246	prohibitin 1	Homo sapiens	138-141
24273069-8	2014	Data showed that, 3 months after administration, curcumin treatment reduced Abeta40 , Abeta42 , and aggregation of Abeta-derived diffusible ligands in the mouse hippocampal CA1 area; reduced the expression of the gamma-secretase component presenilin-2; and increased the expression of beta-amyloid-degrading enzymes, including insulin-degrading enzymes and neprilysin.	Curcumin	49-57	membrane metallo endopeptidase	Mus musculus	357-367
24273069-9	2014	This evidence suggests that curcumin, as a potential AD therapeutic method, can reduce beta-amyloid pathological aggregation, possibly through mechanisms that prevent its production by inhibiting presenilin-2 and/or by accelerating its clearance by increasing degrading enzymes such as insulin-degrading enzyme and neprilysin.	Curcumin	28-36	membrane metallo endopeptidase	Mus musculus	315-325
24445050-0	2014	Down-regulation of epidermal growth factor receptor by curcumin-induced UBE1L in human bronchial epithelial cells.	Curcumin	55-63	ubiquitin like modifier activating enzyme 7	Homo sapiens	72-77
24445050-5	2014	For the first time, UBE1L was found to be induced by curcumin in HBE cells.	Curcumin	53-61	ubiquitin like modifier activating enzyme 7	Homo sapiens	20-25
24445050-11	2014	These results uncover a novel chemopreventive mechanism of curcumin in inducing UBE1L and down-regulating EGFR signaling in HBE cells.	Curcumin	59-67	ubiquitin like modifier activating enzyme 7	Homo sapiens	80-85
24467380-11	2014	In silico molecular docking studies suggest that curcumin interacts with Wif-1, Dkk, and GSK-3beta.	Curcumin	49-57	glycogen synthase kinase 3 alpha	Rattus norvegicus	89-98
25374231-0	2014	Comparison between effects of free curcumin and curcumin loaded NIPAAm-MAA nanoparticles on telomerase and PinX1 gene expression in lung cancer cells.	Curcumin	48-56	PIN2 (TERF1) interacting telomerase inhibitor 1	Homo sapiens	107-112
25374231-2	2014	In this article, we compared the effects of pure curcumin and curcumin-loaded NIPAAm-MAA nanoparticles on telomerase and PinX1 gene expression in a lung cancer cell line.	Curcumin	62-70	PIN2 (TERF1) interacting telomerase inhibitor 1	Homo sapiens	121-126
25374231-6	2014	CONCLUSIONS: The results showed that curcumin- loaded- NIPAAm-MAA exerted cytotoxic effects on the Calu-6 cell line through down-regulation of telomerase and stimulation of pinX1 gene expression.	Curcumin	37-45	PIN2 (TERF1) interacting telomerase inhibitor 1	Homo sapiens	173-178
25272063-7	2014	Overexpression of HSPs (27, 70, 90), HSF1, and HDAC6 in leukemia cells were down-regulated by curcumin, and the effects on HSPs 27and 70 were less than that on HSP 90.	Curcumin	94-102	heat shock transcription factor 1	Homo sapiens	37-41
25868812-3	2015	The docking results demonstrated that curcumin has good binding affinity towards CD28 and CD45 receptors as compared to piperine but in vitro studies revealed that piperine is more effective.	Curcumin	38-46	CD28 molecule	Homo sapiens	81-85
25602852-2	2015	However, in this study, we found that curcumin could not only effectively inhibit the proliferation of glioma cells but also induce glioma cells to be stem-like, which showed that it caused some glioma cells to form spheres with CD133 and Nestin positive markers.	Curcumin	38-46	prominin 1	Homo sapiens	229-234
25359171-5	2015	Also, supplementation with curcumin and quercetin separately to BP-treated mice brought a significant improvement in the enzyme activities of caspase 9 as well as caspase 3 but the improvement was more pronounced following combined treatment.	Curcumin	27-35	caspase 9	Mus musculus	142-151
25445048-0	2015	Curcumin regulates peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression by AMPK pathway in hepatic stellate cells in vitro.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	101-105
25824783-0	2015	Dendrosomal curcumin inhibits metastatic potential of human SW480 colon cancer cells through Down-regulation of Claudin1, Zeb1 and Hef1-1 gene expression.	Curcumin	12-20	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	131-137
25640336-7	2015	Curcumin significantly lowered the serum levels of AFP, IL-2 and IL-6, ALT, ALT, and malondialdehyde (MDA) as well gene expression of IL-2 and IL-6.	Curcumin	0-8	alpha-fetoprotein	Rattus norvegicus	51-54
26235577-6	2015	Results showed that pretreatment with curcumin significantly attenuated the H2O2-induced HUVECs" premature senescence, which was evidenced by a decreased percentage of senescence-associated beta-galactosidase positive cells, improved cell division and decreased expression of senescence-associated protein p21 (all p&lt;0.05).	Curcumin	38-46	galactosidase beta 1	Homo sapiens	190-208
26004618-10	2015	Curcumin and quercetin treatments to mice were able to decrease significantly the levels of LPO, ROS, as well as activities of SOD, GST.	Curcumin	0-8	lactoperoxidase	Mus musculus	92-95
26236379-5	2015	Among all selected natural compounds, curcumin was found to be the most effective compound against GCGR followed by amorfrutin 1 and 4-hydroxyderricin.	Curcumin	38-46	glucagon receptor	Homo sapiens	99-103
25646051-0	2015	Curcumin Suppresses the Production of Pro-inflammatory Cytokine Interleukin-18 in Lipopolysaccharide Stimulated Murine Macrophage-Like Cells.	Curcumin	0-8	interleukin 18	Mus musculus	64-78
25646051-3	2015	As curcumin induced inhibition of IL-18 production in keratinocytes and mice is well known, effect of curcumin on IL-18 release in macrophages remains unknown.	Curcumin	3-11	interleukin 18	Mus musculus	34-39
25646051-3	2015	As curcumin induced inhibition of IL-18 production in keratinocytes and mice is well known, effect of curcumin on IL-18 release in macrophages remains unknown.	Curcumin	102-110	interleukin 18	Mus musculus	114-119
25646051-4	2015	Hence, this present study has been designed to evaluate the effect of curcumin on IL-18 production and necrotic cell death in murine macrophages-like cells treated with or without lipopolysaccharide (LPS).	Curcumin	70-78	interleukin 18	Mus musculus	82-87
25646051-6	2015	Our results demonstrate that curcumin significantly inhibited the production of pro-inflammatory cytokine IL-18 in E.coli LPS stimulated murine macrophage-like cells RAW264.7 in a concentration-dependent manner.	Curcumin	29-37	interleukin 18	Mus musculus	106-111
25492214-4	2015	According to the flow cytometric analysis, curcumin treatment resulted in G2/M arrest in AGS cells, accompanied with an increased expression of cyclin B1 and a decreased expression of cyclin D1.	Curcumin	43-51	cyclin D1	Homo sapiens	184-193
25431425-12	2014	Furthermore, curcumin treatment greatly reduced phosphorylation of CREB, followed by a concomitant reduction of NF-kappaB (p50 and p65) subunit activation.	Curcumin	13-21	RELA proto-oncogene, NF-kB subunit	Homo sapiens	131-134
25240837-6	2014	In both cell lines curcumin induced relatively fast activation of neutral sphingomyelinase (nSMase), which peaked at 3 h, and was followed by inhibition of sphingomyelin synthase activity.	Curcumin	19-27	sphingomyelin phosphodiesterase 2	Homo sapiens	66-90
25240837-6	2014	In both cell lines curcumin induced relatively fast activation of neutral sphingomyelinase (nSMase), which peaked at 3 h, and was followed by inhibition of sphingomyelin synthase activity.	Curcumin	19-27	sphingomyelin phosphodiesterase 2	Homo sapiens	92-98
25240837-9	2014	Inhibition of nSMase activity with GW4869 or silencing ofSMPD3 gene encoding nSMase2 reversed the curcumin-induced inhibition of sphingomyelin synthase without affecting the glucosylceramide synthase activity.	Curcumin	98-106	sphingomyelin phosphodiesterase 2	Homo sapiens	14-20
25240837-10	2014	The early ceramide generation by nSMase was indispensable for the later lipid accumulation, modulation of Bax, Bcl-2 and caspase 3 levels, and for reduction of cell viability in curcumin-treated cells, as all these events were inhibited by GW4869 or nSMase2 depletion.	Curcumin	178-186	sphingomyelin phosphodiesterase 2	Homo sapiens	33-39
25554986-9	2014	The elevated proapoptotic proteins caspase 3 and Bax expression in cytoplasm and nucleus of hepatocytes of gentamicin-injected rats were reduced to normal value as a result of thymoquinone and curcumin administration while the lowered expression of antiapoptotic protein Bcl-2 was increased.	Curcumin	193-201	caspase 3	Rattus norvegicus	35-44
25256401-5	2014	We observed that curcumin suppressed cell growth, migration and invasion, and induced cell apoptosis, which is associated with increased expression of miR-7 and subsequently decreased expression of SET8, one of the miR-7 targets.	Curcumin	17-25	lysine methyltransferase 5A	Homo sapiens	198-202
24896104-6	2014	Curcumin treatment down-regulated the expression of hsa-miR-125a-5p, hsa-miR-574-3p and hsa-miR-210 as determined by miRNA microarray analysis and qPCR (real-time quantitative reverse transcription-PCR).	Curcumin	0-8	microRNA 210	Homo sapiens	92-99
25172633-4	2014	On the other hand, curcumin fluorescence colocalized with nucleophosmin, a nucleolus marker protein.	Curcumin	19-27	nucleophosmin 1	Homo sapiens	58-71
25360677-7	2014	Importantly, low-dose curcumin gave a transient activation of p38 kinases, which is in contrast to the high dose curcumin effects on cancer cells in which these MAP kinases tend to undergo prolonged activation.	Curcumin	22-30	mitogen-activated protein kinase 14	Mus musculus	62-65
25360677-8	2014	Low-dose curcumin mediated effects on OECs demonstrate cell-type specific stimulation of p38 and ERK kinases.	Curcumin	9-17	mitogen-activated protein kinase 14	Mus musculus	89-92
25458791-6	2014	In addition, we identified that a curcumin analog, F36, exhibited more potent inhibitory effect in colorectal cancer cells than curcumin through inhibiting SERCA2 expression.	Curcumin	34-42	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	156-162
25458791-6	2014	In addition, we identified that a curcumin analog, F36, exhibited more potent inhibitory effect in colorectal cancer cells than curcumin through inhibiting SERCA2 expression.	Curcumin	128-136	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	156-162
25458791-8	2014	Curcumin analog F36 shows enhanced anti-cancer activity in colorectal cancer cells by targeting SERCA2.	Curcumin	0-8	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	96-102
25282128-9	2014	Curcumin reduced the mRNA and protein expression of intracellular adhesion molecule-1, vascular cell adhesion molecule-1, P-selectin, and monocyte chemotactic protein-1, and it inhibited HCD-induced up-regulation of MMP-1, MMP-2, and MMP-9.	Curcumin	0-8	interstitial collagenase	Oryctolagus cuniculus	216-221
25282128-9	2014	Curcumin reduced the mRNA and protein expression of intracellular adhesion molecule-1, vascular cell adhesion molecule-1, P-selectin, and monocyte chemotactic protein-1, and it inhibited HCD-induced up-regulation of MMP-1, MMP-2, and MMP-9.	Curcumin	0-8	matrix metalloproteinase-9	Oryctolagus cuniculus	234-239
25241044-0	2014	Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	55-59
25241044-8	2014	Furthermore, curcumin reversed PMA stimulated PKC activation and suppressed the chronic activation of AMPK, which in turn reduced the expression of MMP-9, MMP-13 and EMMPRIN.	Curcumin	13-21	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	102-106
25241044-9	2014	Therefore, it is suggested that curcumin by inhibiting AMPK-MAPK (mitogen activated protein kinase) and PKC pathway may led to down-regulated EMMPRIN, MMP-9 and MMP-13 expression in PMA-induced THP-1 cells.	Curcumin	32-40	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	55-59
25400722-8	2014	Curcumin also inhibited SCC-25 cells invasion and downregulated MMP-2, MMP-9, uPA and uPAR expression.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	64-69
25104884-4	2014	Two groups of rats were treated by daily oral intubation with a chemically modified curcumin, CMC 2.24, for two weeks; the control groups received vehicle alone.	Curcumin	84-92	C-x(9)-C motif containing 2	Rattus norvegicus	94-99
24349037-0	2013	Curcumin intake affects miRNA signature in murine melanoma with mmu-miR-205-5p most significantly altered.	Curcumin	0-8	microRNA 205	Mus musculus	64-75
24349037-10	2013	Furthermore the miRNA expression signature in tumors was substantially altered by curcumin intake with mmu-miR-205-5p over 100 times higher expressed when compared to controls.	Curcumin	82-90	microRNA 205	Mus musculus	103-114
24349037-15	2013	These findings demonstrate a profound alteration of the miRNA expression signature in engrafting curcumin-treated melanoma with mmu-miR-205-5p being up-regulated most significantly.	Curcumin	97-105	microRNA 205	Mus musculus	128-139
25349781-0	2014	ROS-dependent prostate apoptosis response-4 (Par-4) up-regulation and ceramide generation are the prime signaling events associated with curcumin-induced autophagic cell death in human malignant glioma.	Curcumin	137-145	pro-apoptotic WT1 regulator	Homo sapiens	14-43
25349781-0	2014	ROS-dependent prostate apoptosis response-4 (Par-4) up-regulation and ceramide generation are the prime signaling events associated with curcumin-induced autophagic cell death in human malignant glioma.	Curcumin	137-145	pro-apoptotic WT1 regulator	Homo sapiens	45-50
27279695-3	2016	OBJECTIVE: This study was aimed to evaluate the effect of curcumin and ellagic acid on the activity of monoamine oxidase (MAO), the enzyme responsible for metabolism of monoamine neurotransmitters which are pivotal for neuronal development and function.	Curcumin	58-66	monoamine oxidase A	Rattus norvegicus	103-120
25349781-5	2014	Curcumin suppresses the growth of human malignant glioma cells via ROS-dependent prostate apoptosis response-4 (Par-4) induction and ceramide generation.	Curcumin	0-8	pro-apoptotic WT1 regulator	Homo sapiens	81-110
25349781-5	2014	Curcumin suppresses the growth of human malignant glioma cells via ROS-dependent prostate apoptosis response-4 (Par-4) induction and ceramide generation.	Curcumin	0-8	pro-apoptotic WT1 regulator	Homo sapiens	112-117
25349781-6	2014	Extracellular supplementation of antioxidants such as glutathione and N-acetylcysteine to glioma cells abrogated the Par-4 induction, ceramide generation, and in turn, prevented curcumin-induced autophagic cell death.	Curcumin	178-186	pro-apoptotic WT1 regulator	Homo sapiens	117-122
23632743-7	2013	Similarly, chromatin immunoprecipitation (ChIP) analysis showed that curcumin inhibited both AdBMP2-induced and basal histone H3 acetylation levels in the promoter regions of GATA4 and MEF2C, but not of Tbx5.	Curcumin	69-77	T-box transcription factor 5	Rattus norvegicus	203-207
25349781-7	2014	Moreover, tumor cells transfected with Par-4 gene sensitized the curcumin-induced autophagic cell death.	Curcumin	65-73	pro-apoptotic WT1 regulator	Homo sapiens	39-44
27279695-3	2016	OBJECTIVE: This study was aimed to evaluate the effect of curcumin and ellagic acid on the activity of monoamine oxidase (MAO), the enzyme responsible for metabolism of monoamine neurotransmitters which are pivotal for neuronal development and function.	Curcumin	58-66	monoamine oxidase A	Rattus norvegicus	122-125
25349781-8	2014	Overall, this study describes a novel signaling pathway by which curcumin induces ROS-dependent Par-4 activation and ceramide generation, leading to autophagic cell death in human malignant glioma cells.	Curcumin	65-73	pro-apoptotic WT1 regulator	Homo sapiens	96-101
27279695-7	2016	RESULTS: MAO activity was inhibited by curcumin and ellagic acid; however, higher half maximal inhibitory concentrations of curcumin (500.46 nM) and ellagic acid (412.24 nM) were required compared to the known MAO-B inhibitor selegiline.	Curcumin	39-47	monoamine oxidase A	Rattus norvegicus	9-12
27279695-7	2016	RESULTS: MAO activity was inhibited by curcumin and ellagic acid; however, higher half maximal inhibitory concentrations of curcumin (500.46 nM) and ellagic acid (412.24 nM) were required compared to the known MAO-B inhibitor selegiline.	Curcumin	124-132	monoamine oxidase A	Rattus norvegicus	9-12
24064724-3	2013	We identified that curcumin interrupts wnt signaling by decreasing beta-catenin activity, which in turn suppresses the expression of beta-catenin target genes (c-myc, VEGF and cyclin D1).	Curcumin	19-27	cyclin D1	Homo sapiens	176-185
27279695-8	2016	It is observed that the curcumin and ellagic acid inhibit the MAO activity with both the competitive and noncompetitive type of inhibitions.	Curcumin	24-32	monoamine oxidase A	Rattus norvegicus	62-65
23794119-13	2013	Curcumin effect was mediated through activation of TNFR, CASP 8, CASP3, BID, BAX, and down-regulation of NFkappaB, NDRG 1, and BCL2L10 genes.	Curcumin	0-8	caspase 8	Homo sapiens	57-63
27279695-9	2016	CONCLUSIONS: Curcumin and ellagic acid can be considered a possible source of MAO inhibitor used in the treatment of Parkinson"s and other neurological disorders.	Curcumin	13-21	monoamine oxidase A	Rattus norvegicus	78-81
25121739-5	2014	CXCL12-induced CTGF expression was inhibited by a CXCR4 antagonist (AMD3100), small interfering RNA of CXCR4 (CXCR4 siRNA), a dominant negative mutant of Rac1 (RacN17), a mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitor (PD98059), a JNK inhibitor (SP600125), a p21-activated kinase inhibitor (PAK18), c-Jun siRNA, and an AP-1 inhibitor (curcumin).	Curcumin	351-359	C-X-C motif chemokine ligand 12	Homo sapiens	0-6
25121739-5	2014	CXCL12-induced CTGF expression was inhibited by a CXCR4 antagonist (AMD3100), small interfering RNA of CXCR4 (CXCR4 siRNA), a dominant negative mutant of Rac1 (RacN17), a mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitor (PD98059), a JNK inhibitor (SP600125), a p21-activated kinase inhibitor (PAK18), c-Jun siRNA, and an AP-1 inhibitor (curcumin).	Curcumin	351-359	cellular communication network factor 2	Homo sapiens	15-19
24369247-1	2013	OBJECTIVE: To investigate the expressions of mitogen-activated protein kinases (MAPKs) and matrix metalloproteinases (MMPs) in apoptotic human T cell lymphoma Jurkat cells induced by curcumin in vitro and explore the possible molecular mechanisms of curcumin-induced apoptosis.	Curcumin	183-191	matrix metallopeptidase 2	Homo sapiens	118-122
24369247-5	2013	Treatment of Jurkat cells with 25, 50, and 75 micromol/L curcumin resulted in a concentration-dependent increase of JNK and p-JNK expressions (P&lt;0.01) without significantly affecting the expressions of ERK1/2 and P38 MAPK or the activity of MMP-2 and MMP-9.	Curcumin	57-65	matrix metallopeptidase 2	Homo sapiens	244-249
26776764-8	2016	These results suggested for the first time that curcumin in low concentrations played a protective role in benzidine-induced ERK1/2/AP-1 activation and proliferation of bladder cancer cells, therefore providing new insights into the pathogenesis and chemoprevention of benzidine-associated bladder cancer.	Curcumin	48-56	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-136
24857828-9	2014	The expression of DHAND and EHAND is significantly down-regulated and up-regulated in the groups treated with curcumin and SAHA.	Curcumin	110-118	heart and neural crest derivatives expressed 1	Mus musculus	28-33
24857828-10	2014	Furthermore, our results from ChIP assays have shown that the histone H3K14ac connects with the DHAND and EHAND genes are significantly inhibited by curcumin and simulated by SAHA.	Curcumin	149-157	heart and neural crest derivatives expressed 1	Mus musculus	106-111
27226186-24	2016	These effects of curcumin in rats with capsaicin denervation were restored by concomitant treatment with exogenous calcitonin gene related pepetide (CGRP) combined with curcumin and subsequently exposed to WRS.	Curcumin	17-25	calcitonin-related polypeptide alpha	Rattus norvegicus	149-153
24142484-5	2014	To enhance delivery, we coupled curcumin to the glioblastoma-specific CD68 antibody in a releasable form.	Curcumin	32-40	CD68 antigen	Mus musculus	70-74
27226186-25	2016	The expression of mRNA for TNF-alpha, COX-2 and iNOS was significantly increased (P &lt; 0.05) in vehicle-pretreated control rats exposed to WRS and significantly attenuated (P &lt; 0.05) by curcumin administered in graded dosages.	Curcumin	191-199	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	38-43
24142484-8	2014	GL261-implanted mice receiving intratumor infusions of the curcumin-CD68 adduct followed by tail-vein injections of solubilized curcumin displayed a fourfold to fivefold reduction in brain tumor load, survived longer, and about 10% of them lived beyond 100 days.	Curcumin	59-67	CD68 antigen	Mus musculus	68-72
24063989-5	2013	Curcumin significantly reversed the alcohol-induced inhibition of the alcohol dehydrogenase, aldehyde dehydrogenase 2 and antioxidant enzyme activities as well as the activation of cytochrome P4502E1 and promotion of lipid peroxidation (p&lt;0.05).	Curcumin	0-8	aldo-keto reductase family 1, member A1 (aldehyde reductase)	Mus musculus	70-91
27226186-26	2016	We conclude that curcumin exerts gastroprotective and hyperemic activities against experimental stress-induced gastric lesions by mechanism involving endogenous prostaglandins, NO, the neuropeptides such as CGRP released from capsaicin-sensitive afferent nerves and the activation of vanilloid TRPV1 receptors located on these sensory nerve terminals.	Curcumin	17-25	calcitonin-related polypeptide alpha	Rattus norvegicus	207-211
27226186-26	2016	We conclude that curcumin exerts gastroprotective and hyperemic activities against experimental stress-induced gastric lesions by mechanism involving endogenous prostaglandins, NO, the neuropeptides such as CGRP released from capsaicin-sensitive afferent nerves and the activation of vanilloid TRPV1 receptors located on these sensory nerve terminals.	Curcumin	17-25	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	294-299
24835302-8	2014	Western blot analysis showed that the expressions of IkB, nuclear p65, cyclooxygenase 2 (COX-2) and p-ERK1/2 were down-regulated by curcumin in vitro.	Curcumin	132-140	prostaglandin-endoperoxide synthase 2	Mus musculus	71-87
26863117-0	2016	DIFFERENTIAL SUSCEPTIBILITY OF HUMAN SP-B GENETIC VARIANTS ON LUNG INJURY CAUSED BY BACTERIAL PNEUMONIA AND THE EFFECT OF A CHEMICALLY MODIFIED CURCUMIN.	Curcumin	144-152	surfactant protein B	Homo sapiens	37-41
24835302-8	2014	Western blot analysis showed that the expressions of IkB, nuclear p65, cyclooxygenase 2 (COX-2) and p-ERK1/2 were down-regulated by curcumin in vitro.	Curcumin	132-140	prostaglandin-endoperoxide synthase 2	Mus musculus	89-94
24835302-8	2014	Western blot analysis showed that the expressions of IkB, nuclear p65, cyclooxygenase 2 (COX-2) and p-ERK1/2 were down-regulated by curcumin in vitro.	Curcumin	132-140	mitogen-activated protein kinase 3	Mus musculus	102-108
24835302-10	2014	Curcumin reduced COX-2 expression in subcutaneous tumors in vivo and caused a 36% decrease in weight of intralung tumors (P=.048) accompanied by a significant survival rate increase (hazard ratio=2.728, P=.036).	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	17-22
24835302-11	2014	Curcumin inhibition of COX-2, p65 expression and ERK1/2 activity in NSCLC cells was associated with decreased survival and increased induction of apoptosis.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	23-28
24835302-11	2014	Curcumin inhibition of COX-2, p65 expression and ERK1/2 activity in NSCLC cells was associated with decreased survival and increased induction of apoptosis.	Curcumin	0-8	mitogen-activated protein kinase 3	Mus musculus	49-55
23954730-0	2013	Free and nanoencapsulated curcumin suppress beta-amyloid-induced cognitive impairments in rats: involvement of BDNF and Akt/GSK-3beta signaling pathway.	Curcumin	26-34	glycogen synthase kinase 3 beta	Rattus norvegicus	124-133
23954767-9	2013	Additionally, both curcumin and C3 activated the PI3/Akt pathway, however, Nrf2 activation was independent of this pathway, and therefore, we hypothesized that both curcumin and C3 activated phase II enzymes via directly disrupting the Nrf2/Keap1 complex and promoting Nrf2"s nuclear translocation.	Curcumin	19-27	peptidase inhibitor 3	Homo sapiens	49-52
23954767-9	2013	Additionally, both curcumin and C3 activated the PI3/Akt pathway, however, Nrf2 activation was independent of this pathway, and therefore, we hypothesized that both curcumin and C3 activated phase II enzymes via directly disrupting the Nrf2/Keap1 complex and promoting Nrf2"s nuclear translocation.	Curcumin	165-173	peptidase inhibitor 3	Homo sapiens	49-52
24142718-0	2013	Downregulation of p38 MAPK involved in inhibition of LDL-induced proliferation of mesangial cells and matrix by curcumin.	Curcumin	112-120	mitogen activated protein kinase 14	Rattus norvegicus	18-21
26863117-5	2016	Our hypothesis is that functional differences of SP-B variants and treatment with curcumin (CMC2.24) modulate lung injury in bacterial pneumonia.	Curcumin	82-90	COX assembly mitochondrial protein 2	Mus musculus	92-96
24142718-5	2013	When LDL-induced cells were treated with curcumin in the concentration of 12.5 or 25.0 mumol/L, LDL-induced proliferation of mesangial cells was suppressed, the expression of MMP-2 mRNA and protein increased, the expression of COX-2 mRNA and protein downregulated, the production of ROS inhibited and p38 MAPK inactivated (P&lt;0.05).	Curcumin	41-49	matrix metallopeptidase 2	Rattus norvegicus	175-180
24142718-5	2013	When LDL-induced cells were treated with curcumin in the concentration of 12.5 or 25.0 mumol/L, LDL-induced proliferation of mesangial cells was suppressed, the expression of MMP-2 mRNA and protein increased, the expression of COX-2 mRNA and protein downregulated, the production of ROS inhibited and p38 MAPK inactivated (P&lt;0.05).	Curcumin	41-49	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	227-232
24142718-5	2013	When LDL-induced cells were treated with curcumin in the concentration of 12.5 or 25.0 mumol/L, LDL-induced proliferation of mesangial cells was suppressed, the expression of MMP-2 mRNA and protein increased, the expression of COX-2 mRNA and protein downregulated, the production of ROS inhibited and p38 MAPK inactivated (P&lt;0.05).	Curcumin	41-49	mitogen activated protein kinase 14	Rattus norvegicus	301-304
24142718-6	2013	In conclusion, curcumin can inhibit the LDL-induced proliferation of mesangial cells and up-regulate the expression of MMP-2, which may be related with the inhibitory effect of curcumin on COX-2 expression, ROS production and p38 MAPK.	Curcumin	15-23	matrix metallopeptidase 2	Rattus norvegicus	119-124
25026938-13	2014	CONCLUSIONS: Results showed that curcumin entrapped folate conjugated cross-linked acrylic polymer (FA-CLAP) hydrogel showed higher cellular uptake than the non folate conjugated form.	Curcumin	33-41	BCL10 immune signaling adaptor	Homo sapiens	103-107
26919094-3	2016	Our previous research revealed that the curcumin derivative B19 could induce cancer cell apoptosis via activation of endoplasmic reticulum (ER) stress.	Curcumin	40-48	eva-1 homolog C	Homo sapiens	60-63
24680995-7	2014	We found that curcumin prevented ICH-induced inflammatory molecules through NF-kappaB activation via the p38MAPK/PKC pathway in vitro.	Curcumin	14-22	mitogen-activated protein kinase 14	Mus musculus	105-112
24142718-6	2013	In conclusion, curcumin can inhibit the LDL-induced proliferation of mesangial cells and up-regulate the expression of MMP-2, which may be related with the inhibitory effect of curcumin on COX-2 expression, ROS production and p38 MAPK.	Curcumin	15-23	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	189-194
24142718-6	2013	In conclusion, curcumin can inhibit the LDL-induced proliferation of mesangial cells and up-regulate the expression of MMP-2, which may be related with the inhibitory effect of curcumin on COX-2 expression, ROS production and p38 MAPK.	Curcumin	15-23	mitogen activated protein kinase 14	Rattus norvegicus	226-229
24142718-6	2013	In conclusion, curcumin can inhibit the LDL-induced proliferation of mesangial cells and up-regulate the expression of MMP-2, which may be related with the inhibitory effect of curcumin on COX-2 expression, ROS production and p38 MAPK.	Curcumin	177-185	matrix metallopeptidase 2	Rattus norvegicus	119-124
24142718-6	2013	In conclusion, curcumin can inhibit the LDL-induced proliferation of mesangial cells and up-regulate the expression of MMP-2, which may be related with the inhibitory effect of curcumin on COX-2 expression, ROS production and p38 MAPK.	Curcumin	177-185	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	189-194
24142718-6	2013	In conclusion, curcumin can inhibit the LDL-induced proliferation of mesangial cells and up-regulate the expression of MMP-2, which may be related with the inhibitory effect of curcumin on COX-2 expression, ROS production and p38 MAPK.	Curcumin	177-185	mitogen activated protein kinase 14	Rattus norvegicus	226-229
24566270-6	2014	The CTCs arrest is mediated by the interaction between ICAM-1 on HUVECs and MUC-1 on cancer cells, and moderate doses of curcumin down-regulate the expression of both molecules.	Curcumin	121-129	mucin 1, cell surface associated	Homo sapiens	76-81
24566270-8	2014	FROM THE CLINICAL EDITOR: In this novel study, lipid nanoparticles encapsulating curcumin were able to prevent metastasis formation and limited the progression of the disease by modulating vascular inflammation and impairing the circulating tumor cells" arrest as a result of down-regulation of ICAM1 and MUC1 in a highly metastatic breast cancer cell line model.	Curcumin	81-89	mucin 1, cell surface associated	Homo sapiens	305-309
26943907-0	2016	The Curcumin Analog C-150, Influencing NF-kappaB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo.	Curcumin	4-12	Relish	Drosophila melanogaster	39-48
24901233-5	2014	Curcumin is a substance which inhibits IL-1 signaling very early by preventing the recruitment of IL-1 receptor associated kinase (IRAK) to the IL-1 receptor.	Curcumin	0-8	interleukin 1 receptor associated kinase 1	Homo sapiens	98-129
24901233-5	2014	Curcumin is a substance which inhibits IL-1 signaling very early by preventing the recruitment of IL-1 receptor associated kinase (IRAK) to the IL-1 receptor.	Curcumin	0-8	interleukin 1 receptor associated kinase 1	Homo sapiens	131-135
23816368-9	2013	Curcumin, in the presence of Abeta, activated Akt which in turn phosphorylates GSK-3beta, and resulted in the inhibition of GSK-3beta.	Curcumin	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	79-88
23816368-9	2013	Curcumin, in the presence of Abeta, activated Akt which in turn phosphorylates GSK-3beta, and resulted in the inhibition of GSK-3beta.	Curcumin	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	124-133
23807697-5	2013	Curcumin inhibited the cell proliferation induced by platelet-derived growth factor (PDGF) and decreased the PDGF-induced phosphorylation of ERK1/2 in the rat ASMCs.	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	141-147
23754571-6	2013	Finally curcumin modulates miRNAs (miR-15a, miR-16, miR-21, miR-22, miR-26, miR-101, miR-146, miR-200, miR-203, and let-7) and their multiple target genes.	Curcumin	8-16	microRNA 15a	Homo sapiens	35-42
23754571-6	2013	Finally curcumin modulates miRNAs (miR-15a, miR-16, miR-21, miR-22, miR-26, miR-101, miR-146, miR-200, miR-203, and let-7) and their multiple target genes.	Curcumin	8-16	microRNA 203a	Homo sapiens	103-110
23893477-8	2014	The anticonvulsant effect of curcumin (80 mg/kg) was prevented by 8-phenyltheophylline (0.5 mg/kg, i.p., non-selective adenosine receptor antagonist) and 8-cyclopentyl-1,3-dipropylxanthine (5 mg/kg, i.p., adenosine A1 receptor antagonist) but not by 8-(3-cholorostryl)caffeine (4 mg/kg, i.p., adenosine A2A receptor antagonist).	Curcumin	29-37	adenosine A2a receptor	Mus musculus	293-315
26998027-0	2016	Curcumin suppresses transforming growth factor-beta1-induced cardiac fibroblast differentiation via inhibition of Smad-2 and p38 MAPK signaling pathways.	Curcumin	0-8	mitogen activated protein kinase 14	Rattus norvegicus	125-128
23943274-3	2014	Thus, patients suffering from these PAK1-dependent diseases have to rely on solely a variety of herbal therapeutics such as propolis and curcumin that block PAK1 without affecting normal cell growth.	Curcumin	137-145	p21 (RAC1) activated kinase 1	Homo sapiens	36-40
26998027-8	2016	Furthermore, phosphorylated Smad-2 and p38 were upregulated in TGF-beta1-induced CFs, and these effects were substantially inhibited by curcumin administration.	Curcumin	136-144	mitogen activated protein kinase 14	Rattus norvegicus	39-42
26998027-9	2016	In conclusion, the results of the present study demonstrated that treatment with curcumin effectively suppresses TGF-beta1-induced CF differentiation via Smad-2 and p38 signaling pathways.	Curcumin	81-89	mitogen activated protein kinase 14	Rattus norvegicus	165-168
26422756-9	2016	H2S also increased activator protein 1 (AP-1) binding activity with SIRT3 promoter and this effect was absent in the presence of the specific AP-1 inhibitor, SR11302 or curcumin.	Curcumin	169-177	jun proto-oncogene	Mus musculus	40-44
24966519-8	2014	Out of all the selected compounds, rosmarinic acid and curcumin proved to be the most potent inhibitors of Caspase-8 with binding energy (DeltaG) of -7.10 Kcal/mol and -7.08 Kcal/mol, respectively.	Curcumin	55-63	caspase 8	Homo sapiens	107-116
23936448-0	2013	Curcumin protects microglia and primary rat cortical neurons against HIV-1 gp120-mediated inflammation and apoptosis.	Curcumin	0-8	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	75-80
23936448-6	2013	Curcumin may exert its biological activities through inhibition of the delayed rectification and transient outward potassium (K(+)) current, as curcumin effectively reduced HIV-1 gp120-mediated elevation of the delayed rectification and transient outward K(+) channel current in neurons.	Curcumin	0-8	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	179-184
23936448-6	2013	Curcumin may exert its biological activities through inhibition of the delayed rectification and transient outward potassium (K(+)) current, as curcumin effectively reduced HIV-1 gp120-mediated elevation of the delayed rectification and transient outward K(+) channel current in neurons.	Curcumin	144-152	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	179-184
23936448-8	2013	Curcumin reduces production of ROS and inflammatory mediators in HIV-1-gp120-stimulated microglia, and protects cortical neurons against HIV-1-mediated apoptosis, most likely through inhibition of HIV-1 gp120-induced elevation of the delayed rectification and transient outward K(+) current.	Curcumin	0-8	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	71-76
24705375-10	2014	However, the enzyme activities of caspase 3 and caspase 9 showed a significant increase upon treatment with curcumin and resveratrol.	Curcumin	108-116	caspase 9	Mus musculus	48-57
26677102-12	2016	In addition, curcumin upregulated the mRNA expression levels of transcription factors that favor osteoblast differentiation and increased the ratio of OPG to RANKL.	Curcumin	13-21	TNF superfamily member 11	Rattus norvegicus	158-163
26696252-0	2016	Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3beta Inhibitors.	Curcumin	19-27	glycogen synthase kinase 3 beta	Homo sapiens	87-96
24550143-0	2014	Curcumin suppresses proliferation of colon cancer cells by targeting CDK2.	Curcumin	0-8	cyclin dependent kinase 2	Homo sapiens	69-73
24550143-4	2014	Cyclin-dependent kinase 2 (CDK2), a major cell-cycle protein, was identified as a potential molecular target of curcumin.	Curcumin	112-120	cyclin dependent kinase 2	Homo sapiens	0-25
24550143-4	2014	Cyclin-dependent kinase 2 (CDK2), a major cell-cycle protein, was identified as a potential molecular target of curcumin.	Curcumin	112-120	cyclin dependent kinase 2	Homo sapiens	27-31
24550143-5	2014	Indeed, in vitro and ex vivo kinase assay data revealed a dramatic suppressive effect of curcumin on CDK2 kinase activity.	Curcumin	89-97	cyclin dependent kinase 2	Homo sapiens	101-105
24550143-6	2014	Furthermore, curcumin induced G1 cell-cycle arrest, which is regulated by CDK2 in HCT116 cells.	Curcumin	13-21	cyclin dependent kinase 2	Homo sapiens	74-78
23936448-8	2013	Curcumin reduces production of ROS and inflammatory mediators in HIV-1-gp120-stimulated microglia, and protects cortical neurons against HIV-1-mediated apoptosis, most likely through inhibition of HIV-1 gp120-induced elevation of the delayed rectification and transient outward K(+) current.	Curcumin	0-8	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	203-208
22653297-8	2013	Lifespan extension of curcumin in Drosophila was associated with the up-regulation of Mn-SOD and CuZn-SOD genes, and the down-regulation of dInR, ATTD, Def, CecB, and DptB genes.	Curcumin	22-30	Superoxide dismutase 1	Drosophila melanogaster	86-92
22653297-8	2013	Lifespan extension of curcumin in Drosophila was associated with the up-regulation of Mn-SOD and CuZn-SOD genes, and the down-regulation of dInR, ATTD, Def, CecB, and DptB genes.	Curcumin	22-30	Superoxide dismutase 1	Drosophila melanogaster	97-105
22653297-9	2013	The present results suggest that curcumin increases mean lifespan of Drosophila via regulating gene expression of the key enzyme SOD and reducing accumulation of MDA and lipid peroxidation.	Curcumin	33-41	Superoxide dismutase 1	Drosophila melanogaster	129-132
23874455-4	2013	Pharmacologic targeting of STAT3 expression in cervical cancer cell lines either by STAT3-specific siRNA or blocking its tyrosine phosphorylation by AG490 or curcumin led to dose-dependent accumulation of p53 and pRb in cervical cancer cells.	Curcumin	158-166	RB transcriptional corepressor 1	Homo sapiens	213-216
24550143-7	2014	Although the expression levels of CDK2 and its regulatory subunit, cyclin E, were not changed, the phosphorylation of retinoblastoma (Rb), a well-known CDK2 substrate, was reduced by curcumin.	Curcumin	183-191	RB transcriptional corepressor 1	Homo sapiens	134-136
24550143-7	2014	Although the expression levels of CDK2 and its regulatory subunit, cyclin E, were not changed, the phosphorylation of retinoblastoma (Rb), a well-known CDK2 substrate, was reduced by curcumin.	Curcumin	183-191	cyclin dependent kinase 2	Homo sapiens	152-156
26713546-8	2016	Treatment with curcumin inhibited the rise of malondialdehyde (MDA), total oxidant status (TOS) and suppressed the protein expression of extracellular kinase 1/2 (ERK 1/2), p38 in the skeletal muscle of fructose fed rats.	Curcumin	15-23	mitogen activated protein kinase 3	Rattus norvegicus	163-170
24550143-10	2014	To determine whether CDK2 is a direct target of curcumin, CDK2 expression was knocked down in HCT116 cells.	Curcumin	48-56	cyclin dependent kinase 2	Homo sapiens	21-25
24550143-13	2014	From these results, we identified CDK2 as a direct target of curcumin in colon cancer cells.	Curcumin	61-69	cyclin dependent kinase 2	Homo sapiens	34-38
26713546-8	2016	Treatment with curcumin inhibited the rise of malondialdehyde (MDA), total oxidant status (TOS) and suppressed the protein expression of extracellular kinase 1/2 (ERK 1/2), p38 in the skeletal muscle of fructose fed rats.	Curcumin	15-23	mitogen activated protein kinase 14	Rattus norvegicus	173-176
23430957-0	2013	Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases.	Curcumin	5-13	suppressor of cytokine signaling 3	Homo sapiens	52-57
26587568-0	2016	Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes.	Curcumin	15-23	islet amyloid polypeptide	Homo sapiens	38-43
23430957-3	2013	However, whether curcumin can regulate the expression of SOCS1 and SOCS3 is still unknown.	Curcumin	17-25	suppressor of cytokine signaling 3	Homo sapiens	67-72
23430957-4	2013	Here, we found that curcumin elevated the expression of SOCS1 and SOCS3 via triggering acetylation of histone in the regions of SOCS1 and SOCS3 promoter in K562 and HEL cells.	Curcumin	20-28	suppressor of cytokine signaling 3	Homo sapiens	66-71
23430957-4	2013	Here, we found that curcumin elevated the expression of SOCS1 and SOCS3 via triggering acetylation of histone in the regions of SOCS1 and SOCS3 promoter in K562 and HEL cells.	Curcumin	20-28	suppressor of cytokine signaling 3	Homo sapiens	138-143
23430957-8	2013	Thus, HDAC8 plays an important role in the modulation of SOCS1 and SOCS3 by curcumin.	Curcumin	76-84	suppressor of cytokine signaling 3	Homo sapiens	67-72
23430957-10	2013	Furthermore, curcumin increased the transcript levels of SOCS1 and SOCS3 and significantly inhibited the clonogenic activity of hematopoietic progenitors from patients with MPNs.	Curcumin	13-21	suppressor of cytokine signaling 3	Homo sapiens	67-72
23430957-12	2013	Taken together, our data uncover a regulatory mechanism of SOCS1 and SOCS3 through inhibition of HDAC activity (especially HDAC8) by curcumin.	Curcumin	133-141	suppressor of cytokine signaling 3	Homo sapiens	69-74
24375813-5	2014	We demonstrated that nitrosative stress induced disruption of the cellular estrogenic status can be prevented through diphenyl difluoroketone (EF24, curcumin analog) intervention by protecting PDI from reactive oxygen species (ROS)-induced damage.	Curcumin	149-157	prolyl 4-hydroxylase subunit beta	Homo sapiens	193-196
24313805-0	2014	Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	0-8	Serine/threonine-protein kinase akt-1	Caenorhabditis elegans	95-100
24313805-5	2014	Moreover, curcumin induced the expression of the gst-4 and hsp-16.2 stress response genes.	Curcumin	10-18	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	59-67
24313805-6	2014	Lastly, our findings from the mechanistic study in this investigation suggest that the antioxidative effect of curcumin is mediated via regulation of age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	111-119	Serine/threonine-protein kinase akt-1	Caenorhabditis elegans	157-162
24402549-6	2014	The laser confocal scanning microscope results demonstrated the co-localization of PHB with p53, c-Myc, Bax, and Fas in HaCaT cells, and this co-localization region was transferred as a result of curcumin treatment.	Curcumin	196-204	prohibitin 1	Homo sapiens	83-86
26587568-4	2016	Herein, a water-soluble curcumin derivative, CurDAc, is used to investigate the mitigation of hIAPP aggregation in the absence and presence of lipid membrane.	Curcumin	24-32	islet amyloid polypeptide	Homo sapiens	94-99
24188406-0	2014	Curcumin attenuates amyloid-beta-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3beta signaling pathway.	Curcumin	0-8	glycogen synthase kinase 3 beta	Homo sapiens	122-131
24188406-5	2014	The results indicated that curcumin inhibits Abeta-induced tau phosphorylation at Thr231 and Ser396, over-expression of HDAC6, and decrease in phosphorylation of glycogen synthase kinase-3beta (GSK-3beta) at Ser9.	Curcumin	27-35	glycogen synthase kinase 3 beta	Homo sapiens	162-192
28234242-0	2016	Effect of curcumin on inhibiting atherogenesis by down-regulating lipocalin-2 expression in apolipoprotein E knockout mice.	Curcumin	10-18	lipocalin 2	Mus musculus	66-77
24188406-5	2014	The results indicated that curcumin inhibits Abeta-induced tau phosphorylation at Thr231 and Ser396, over-expression of HDAC6, and decrease in phosphorylation of glycogen synthase kinase-3beta (GSK-3beta) at Ser9.	Curcumin	27-35	glycogen synthase kinase 3 beta	Homo sapiens	194-203
24188406-6	2014	However, the protective effect of curcumin on dephosphorylation of GSK-3beta induced by Abeta is not directly related to cellular oxidative stress.	Curcumin	34-42	glycogen synthase kinase 3 beta	Homo sapiens	67-76
28234242-3	2016	However, research on the effect of curcumin on regulating LCN2 expression in atherogenesis is very limited.	Curcumin	35-43	lipocalin 2	Mus musculus	58-62
24188406-11	2014	These results imply that curcumin inhibits Abeta-induced tau hyperphosphorylation involving PTEN/Akt/GSK-3beta pathway.	Curcumin	25-33	glycogen synthase kinase 3 beta	Homo sapiens	101-110
23500667-0	2013	Curcumin ameliorates ethanol-induced memory deficits and enhanced brain nitric oxide synthase activity in mice.	Curcumin	0-8	nitric oxide synthase 1, neuronal	Mus musculus	72-93
23825622-8	2013	We inferred that curcumin was capable of impacting the IL-23/IL-17A axis by inhibiting IL-1beta/IL-6 and then indirectly down-regulating IL-17A/IL-22 production.	Curcumin	17-25	interleukin 23, alpha subunit p19	Mus musculus	55-60
24482695-0	2014	Curcumin treatment alters ERK-1/2 signaling in vitro and inhibits nasopharyngeal carcinoma proliferation in mouse xenografts.	Curcumin	0-8	mitogen-activated protein kinase 3	Mus musculus	26-33
28234242-4	2016	The aim of the study was to investigate whether curcumin could alleviate atherosclerosis in ApoE-/- mice by down-regulating LCN2 expression.	Curcumin	48-56	lipocalin 2	Mus musculus	124-128
24482695-3	2014	In this study, the effect of curcumin on ERK-1/2 pathway protein expression and on proliferation of nasopharyngeal carcinoma cells was investigated.	Curcumin	29-37	mitogen-activated protein kinase 3	Mus musculus	41-48
24482695-6	2014	Additionally, Western blotting revealed that expression of p-ERK-1/2, MMP-9, and TIMP-1 was altered following curcumin treatment, also in a dose-dependent manner.	Curcumin	110-118	matrix metallopeptidase 9	Mus musculus	70-75
24482695-11	2014	These results indicate that curcumin treatment can inhibit proliferation of nasopharyngeal carcinoma cells and alter expression of proteins in the ERK-1/2 signaling pathway.	Curcumin	28-36	mitogen-activated protein kinase 3	Mus musculus	147-154
25929263-4	2016	Here, we studied the interaction of curcumin with human CAMK4 at pH 7.4 using molecular docking, molecular dynamics (MD) simulations, fluorescence binding, and surface plasmon resonance (SPR) methods.	Curcumin	36-44	calcium/calmodulin dependent protein kinase IV	Homo sapiens	56-61
24718043-13	2014	The result indicated that treatment of rats with curcumin and sertraline could prevent the stress-induced changes in mPFC.	Curcumin	49-57	complement factor properdin	Mus musculus	117-121
23651519-5	2013	Moreover, the levels of SUMO-1 conjugated proteins, as well as the conjugating enzyme, Ubc9, were decreased, with concomitant treatment with curcumin preventing these effects.	Curcumin	141-149	small ubiquitin like modifier 1	Homo sapiens	24-30
23651519-5	2013	Moreover, the levels of SUMO-1 conjugated proteins, as well as the conjugating enzyme, Ubc9, were decreased, with concomitant treatment with curcumin preventing these effects.	Curcumin	141-149	ubiquitin conjugating enzyme E2 I	Homo sapiens	87-91
25929263-5	2016	We performed MD simulations for both neutral and anionic forms of CAMK4-curcumin complexes for a reasonably long time (150 ns) to see the overall stability of the protein-ligand complex.	Curcumin	72-80	calcium/calmodulin dependent protein kinase IV	Homo sapiens	66-71
23576578-7	2013	Curcumin, an inhibitor of NF-kappaB-induced transcription, blocked ANG II-induced COX-2 protein expression without altering AT1AR internalization, ANG II-induced p65 NF-kappaB nuclear localization, or p42/44 ERK activation.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	82-87
24935585-7	2014	Furthermore, the down-regulation of Bcl-2 and up-regulation of Bax that led to the cleavage of caspase-3 and increased cleaved PARP was observed in SGC-7901 cells treated with curcumin.	Curcumin	176-184	collagen type XI alpha 2 chain	Homo sapiens	127-131
24528023-8	2014	Curcumin and PGV-1 but not PGV-0 decreased localization of p65 into the nucleus induced by Dox, indicating that activation of NF- kB was inhibited.	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	59-62
25929263-6	2016	Molecular docking studies revealed that the curcumin binds in the large hydrophobic cavity of kinase domain of CAMK4 through several hydrophobic and hydrogen-bonded interactions.	Curcumin	44-52	calcium/calmodulin dependent protein kinase IV	Homo sapiens	111-116
25929263-7	2016	Additionally, MD simulations studies contributed in understanding the stability of protein-ligand complex system in aqueous solution and conformational changes in the CAMK4 upon binding of curcumin.	Curcumin	189-197	calcium/calmodulin dependent protein kinase IV	Homo sapiens	167-172
25929263-8	2016	A significant increase in the fluorescence intensity at 495 nm was observed (lambdaexc = 425 nm), suggesting a strong interaction of curcumin to the CAMK4.	Curcumin	133-141	calcium/calmodulin dependent protein kinase IV	Homo sapiens	149-154
25929263-9	2016	A high binding affinity (KD = 3.7 x 10(-8) +- .03 M) of curcumin for the CAMK4 was measured by SPR further indicating curcumin as a potential ligand for the CAMK4.	Curcumin	56-64	calcium/calmodulin dependent protein kinase IV	Homo sapiens	73-78
24716979-0	2014	Curcumin inhibits MHCC97H liver cancer cells by activating ROS/TLR-4/caspase signaling pathway.	Curcumin	0-8	caspase 8	Homo sapiens	69-76
24716979-4	2014	These results showed that as an prooxidant, curcumin exerts anti-cancer effects by inducing apoptosis via the TLR-4/MyD-88 signaling pathway.	Curcumin	44-52	MYD88 innate immune signal transduction adaptor	Homo sapiens	116-122
23660191-0	2013	Curcumin stimulates glucagon-like peptide-1 secretion in GLUTag cells via Ca2+/calmodulin-dependent kinase II activation.	Curcumin	0-8	glucagon	Mus musculus	20-43
23660191-5	2013	In the present study, we demonstrate that curcumin, a yellow pigment isolated from the rhizomes of Curcuma longa L, significantly increases GLP-1 secretion in GLUTag cells, and we clarified the structure-activity relationship using curcumin derivatives.	Curcumin	42-50	glucagon	Mus musculus	140-145
23660191-6	2013	Also, concerning the secretory mechanism, the significant increase in GLP-1 secretion by curcumin involved the Ca(2+)-Ca(2+)/calmodulin-dependent kinase II pathway, and was independent of extracellular signal-regulated kinase, PKC, and the cAMP/PKA-related pathway.	Curcumin	89-97	glucagon	Mus musculus	70-75
23660191-7	2013	These findings provide a molecular mechanism for GLP-1 secretion mediated by foods or drugs, and demonstrate a novel biological function of curcumin in regards to GLP-1 secretion.	Curcumin	140-148	glucagon	Mus musculus	49-54
23660191-7	2013	These findings provide a molecular mechanism for GLP-1 secretion mediated by foods or drugs, and demonstrate a novel biological function of curcumin in regards to GLP-1 secretion.	Curcumin	140-148	glucagon	Mus musculus	163-168
24173373-5	2014	The cytotoxicity of curcumin in hepatocytes was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and the levels of APOBEC-1 mRNA and protein were analyzed by real-time quantitative polymerase chain reaction (qRT-PCR) and western blotting.	Curcumin	20-28	apolipoprotein B mRNA editing enzyme catalytic subunit 1	Rattus norvegicus	160-168
24173373-7	2014	We demonstrated that curcumin concentrations up to 70 microM had no significant cytotoxic effects on primary rat hepatocytes at 24 h. At 15 microM, curcumin significantly increased the expression of APOBEC-1 mRNA and protein, and increased the editing level of apoB mRNA from 3.13 to 7.53%.	Curcumin	148-156	apolipoprotein B mRNA editing enzyme catalytic subunit 1	Rattus norvegicus	199-207
24173373-8	2014	At 25 microM, curcumin reduced the expression of APOBEC-1; however, it did not affect the apoB mRNA editing level.	Curcumin	14-22	apolipoprotein B mRNA editing enzyme catalytic subunit 1	Rattus norvegicus	49-57
24173373-9	2014	Our data suggested that curcumin at a concentration of 15 microM raised the level of apoB-48 and reduced the level of apoB-100 by increasing the expression of APOBEC-1 in primary rat hepatocytes; therefore, curcumin may be a novel preventative therapy for atherosclerosis.	Curcumin	24-32	apolipoprotein B mRNA editing enzyme catalytic subunit 1	Rattus norvegicus	159-167
24173373-9	2014	Our data suggested that curcumin at a concentration of 15 microM raised the level of apoB-48 and reduced the level of apoB-100 by increasing the expression of APOBEC-1 in primary rat hepatocytes; therefore, curcumin may be a novel preventative therapy for atherosclerosis.	Curcumin	207-215	apolipoprotein B mRNA editing enzyme catalytic subunit 1	Rattus norvegicus	159-167
25929263-9	2016	A high binding affinity (KD = 3.7 x 10(-8) +- .03 M) of curcumin for the CAMK4 was measured by SPR further indicating curcumin as a potential ligand for the CAMK4.	Curcumin	56-64	calcium/calmodulin dependent protein kinase IV	Homo sapiens	157-162
23888319-3	2014	Our results found that curcumin inhibited cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1.	Curcumin	23-31	cyclin D1	Homo sapiens	179-188
25929263-9	2016	A high binding affinity (KD = 3.7 x 10(-8) +- .03 M) of curcumin for the CAMK4 was measured by SPR further indicating curcumin as a potential ligand for the CAMK4.	Curcumin	118-126	calcium/calmodulin dependent protein kinase IV	Homo sapiens	73-78
25929263-9	2016	A high binding affinity (KD = 3.7 x 10(-8) +- .03 M) of curcumin for the CAMK4 was measured by SPR further indicating curcumin as a potential ligand for the CAMK4.	Curcumin	118-126	calcium/calmodulin dependent protein kinase IV	Homo sapiens	157-162
27190999-3	2016	In the current study, a novel triketonic chemically modified curcumin, CMC2.24, was tested for efficacy in healing of standardized skin wounds in streptozotocin-induced diabetic rats.	Curcumin	61-69	C-x(9)-C motif containing 2	Rattus norvegicus	71-75
23848205-0	2013	Curcumin potentiates the ability of sunitinib to eliminate the VHL-lacking renal cancer cells 786-O: rapid inhibition of Rb phosphorylation as a preamble to cyclin D1 inhibition.	Curcumin	0-8	cyclin D1	Homo sapiens	157-166
23848205-9	2013	Since curcumin is known to inhibit the cyclin D1-dependent G1/S-phase kinase CDK4 and the cyclin B-dependent G2/M-phase kinase CDK1 that catalyze phosphorylation-mediated inactivation of Rb, our results indicate that SunC containing a lower dose of sunitinib would be effective in restoring the tumor suppressor activity of Rb, thereby truncating cell cycle and triggering cell death.	Curcumin	6-14	cyclin D1	Homo sapiens	39-48
23848205-9	2013	Since curcumin is known to inhibit the cyclin D1-dependent G1/S-phase kinase CDK4 and the cyclin B-dependent G2/M-phase kinase CDK1 that catalyze phosphorylation-mediated inactivation of Rb, our results indicate that SunC containing a lower dose of sunitinib would be effective in restoring the tumor suppressor activity of Rb, thereby truncating cell cycle and triggering cell death.	Curcumin	6-14	cyclin dependent kinase 4	Homo sapiens	77-81
23755374-9	2013	We also found that nano-curcumin significantly up-regulated the expression of the co-stimulatory molecule CD86 in DCs and significantly decreased the secretion of pro-inflammatory cytokines from in vitro activated T cells.	Curcumin	24-32	CD86 molecule	Homo sapiens	106-110
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	100-108	caspase 12	Mus musculus	317-327
26475620-4	2016	Curcumin and hemopressin each alone and in combination ameliorated biochemical and structural fibrotic injury, and downregulated cyclooxygenase-2 (COX-2) and both mRNA and protein levels of nuclear factor kappa B (NF-kappaB) in fibrotic liver.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	129-145
23446753-12	2013	In addition, the combination of curcumin and resveratrol downregulated XIAP and survivin expression.	Curcumin	32-40	X-linked inhibitor of apoptosis	Mus musculus	71-75
23446753-12	2013	In addition, the combination of curcumin and resveratrol downregulated XIAP and survivin expression.	Curcumin	32-40	baculoviral IAP repeat-containing 5	Mus musculus	80-88
23658623-0	2013	Curcumin inhibits CD4(+) T cell activation, but augments CD69 expression and TGF-beta1-mediated generation of regulatory T cells at late phase.	Curcumin	0-8	CD69 molecule	Homo sapiens	57-61
23658623-3	2013	Here, we showed curcumin-mediated regulation of CD2/CD3/CD28-initiated CD4(+) T cell activation in vitro.	Curcumin	16-24	CD28 molecule	Homo sapiens	56-60
23658623-5	2013	We found that curcumin suppresses CD2/CD3/CD28-initiated CD4(+) T cell activation by inhibiting cell proliferation, differentiation and cytokine production.	Curcumin	14-22	CD28 molecule	Homo sapiens	42-46
23658623-6	2013	On the other hand, curcumin attenuated the spontaneous decline of CD69 expression and indirectly increased expression of CCR7, L-selectin and Transforming growth factor-beta1 (TGF-beta1) at the late phase of CD2/CD3/CD28-initiated T cell activation.	Curcumin	19-27	CD69 molecule	Homo sapiens	66-70
24165291-9	2013	Intraperitoneal injection of curcumin in vivo reduced tumor volume, GLI1 expression, the number of positively stained cells, and prolonged the survival period compared with the control group.	Curcumin	29-37	GLI-Kruppel family member GLI1	Mus musculus	68-72
24165291-10	2013	CONCLUSION: This study shows that curcumin holds a great promise for SHH/GLI1 targeted therapy against gliomas.	Curcumin	34-42	GLI-Kruppel family member GLI1	Mus musculus	73-77
24035895-0	2013	Curcumin-induced upregulation of the anti-tau cochaperone BAG2 in primary rat cortical neurons.	Curcumin	0-8	BAG cochaperone 2	Rattus norvegicus	58-62
23658623-6	2013	On the other hand, curcumin attenuated the spontaneous decline of CD69 expression and indirectly increased expression of CCR7, L-selectin and Transforming growth factor-beta1 (TGF-beta1) at the late phase of CD2/CD3/CD28-initiated T cell activation.	Curcumin	19-27	CD28 molecule	Homo sapiens	216-220
23658623-7	2013	Curcumin-mediated up-regulation of CD69 at late phase was associated with ERK1/2 signaling.	Curcumin	0-8	CD69 molecule	Homo sapiens	35-39
23658623-9	2013	CONCLUSIONS/SIGNIFICANCE: Curcumin not merely blocks, but regulates CD2/CD3/CD28-initiated CD4(+) T cell activation by augmenting CD69, CCR7, L-selectin and TGF-beta1 expression followed by regulatory T cell generation.	Curcumin	26-34	CD28 molecule	Homo sapiens	76-80
24035895-3	2013	In this context, our present study examined three polyphenol compounds (curcumin, EGCG and resveratrol) for their possible activity against two endogenous proteins (BAG2 and LAMP1) that are shown to play a vital role in clearing tau tangles from neurons.	Curcumin	72-80	BAG cochaperone 2	Rattus norvegicus	165-169
26475620-4	2016	Curcumin and hemopressin each alone and in combination ameliorated biochemical and structural fibrotic injury, and downregulated cyclooxygenase-2 (COX-2) and both mRNA and protein levels of nuclear factor kappa B (NF-kappaB) in fibrotic liver.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	147-152
24035895-6	2013	Importantly, curcumin doubled BAG2 levels at low micromolar concentrations that are clinically relevant.	Curcumin	13-21	BAG cochaperone 2	Rattus norvegicus	30-34
24035895-7	2013	In addition, curcumin also downregulated levels of phosphorylated tau, which may be potentially attributed to the curcumin-induced upregulation in BAG2 levels in the neurons.	Curcumin	13-21	BAG cochaperone 2	Rattus norvegicus	147-151
26531053-0	2016	Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines.	Curcumin	0-8	cyclin D1	Homo sapiens	96-105
24035895-7	2013	In addition, curcumin also downregulated levels of phosphorylated tau, which may be potentially attributed to the curcumin-induced upregulation in BAG2 levels in the neurons.	Curcumin	114-122	BAG cochaperone 2	Rattus norvegicus	147-151
24035895-8	2013	The present results demonstrate novel activity of polyphenol curcumin in up-regulating an anti-tau cochaperone BAG2 and thus, suggest probable benefit of curcumin against AD-associated tauopathy.	Curcumin	61-69	BAG cochaperone 2	Rattus norvegicus	111-115
23658623-9	2013	CONCLUSIONS/SIGNIFICANCE: Curcumin not merely blocks, but regulates CD2/CD3/CD28-initiated CD4(+) T cell activation by augmenting CD69, CCR7, L-selectin and TGF-beta1 expression followed by regulatory T cell generation.	Curcumin	26-34	CD69 molecule	Homo sapiens	130-134
24035895-8	2013	The present results demonstrate novel activity of polyphenol curcumin in up-regulating an anti-tau cochaperone BAG2 and thus, suggest probable benefit of curcumin against AD-associated tauopathy.	Curcumin	154-162	BAG cochaperone 2	Rattus norvegicus	111-115
26956814-6	2016	Anti-TfR mAb marked S phase arrest and curcumin induced G2/M arrest in tumor cells.	Curcumin	39-47	transferrin receptor	Homo sapiens	5-8
23830979-3	2013	Curcumin, a known antagonist of TNFalpha in multiple cell types and tissues, was chemically modified and conjugated to a thermally responsive elastin-like polypeptide (ELP) to create an injectable depot for sustained, local delivery of curcumin to treat neuroinflammation.	Curcumin	0-8	diazepam binding inhibitor-like 5	Mus musculus	142-166
23830979-3	2013	Curcumin, a known antagonist of TNFalpha in multiple cell types and tissues, was chemically modified and conjugated to a thermally responsive elastin-like polypeptide (ELP) to create an injectable depot for sustained, local delivery of curcumin to treat neuroinflammation.	Curcumin	0-8	diazepam binding inhibitor-like 5	Mus musculus	168-171
23830979-3	2013	Curcumin, a known antagonist of TNFalpha in multiple cell types and tissues, was chemically modified and conjugated to a thermally responsive elastin-like polypeptide (ELP) to create an injectable depot for sustained, local delivery of curcumin to treat neuroinflammation.	Curcumin	236-244	diazepam binding inhibitor-like 5	Mus musculus	142-166
23830979-3	2013	Curcumin, a known antagonist of TNFalpha in multiple cell types and tissues, was chemically modified and conjugated to a thermally responsive elastin-like polypeptide (ELP) to create an injectable depot for sustained, local delivery of curcumin to treat neuroinflammation.	Curcumin	236-244	diazepam binding inhibitor-like 5	Mus musculus	168-171
23830979-5	2013	ELP-curcumin conjugates were shown to display high drug loading, rapidly release curcumin in vitro via degradable carbamate bonds, and retain in vitro bioactivity against TNFalpha-induced cytotoxicity and monocyte activation with IC50 only two-fold higher than curcumin.	Curcumin	4-12	diazepam binding inhibitor-like 5	Mus musculus	0-3
23830979-5	2013	ELP-curcumin conjugates were shown to display high drug loading, rapidly release curcumin in vitro via degradable carbamate bonds, and retain in vitro bioactivity against TNFalpha-induced cytotoxicity and monocyte activation with IC50 only two-fold higher than curcumin.	Curcumin	81-89	diazepam binding inhibitor-like 5	Mus musculus	0-3
23364261-0	2013	Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-kappaB regulation.	Curcumin	0-8	peroxiredoxin 6	Mus musculus	134-139
23364261-3	2013	Herein, we show that curcumin protects HT22 from oxidative and ER stresses evoked by the hypoxia (1% O(2) or CoCl(2) treatment) by enhancing peroxiredoxin 6 (Prdx6) expression.	Curcumin	21-29	peroxiredoxin 6	Mus musculus	141-156
23364261-3	2013	Herein, we show that curcumin protects HT22 from oxidative and ER stresses evoked by the hypoxia (1% O(2) or CoCl(2) treatment) by enhancing peroxiredoxin 6 (Prdx6) expression.	Curcumin	21-29	peroxiredoxin 6	Mus musculus	158-163
23364261-5	2013	When NF-kappaB activity was blocked by using SN50, an inhibitor of NF-kappaB, or cells treated with curcumin, the repression of Prdx6 expression was restored, suggesting the involvement of NF-kappaB in modulating Prdx6 expression.	Curcumin	100-108	peroxiredoxin 6	Mus musculus	128-133
23364261-5	2013	When NF-kappaB activity was blocked by using SN50, an inhibitor of NF-kappaB, or cells treated with curcumin, the repression of Prdx6 expression was restored, suggesting the involvement of NF-kappaB in modulating Prdx6 expression.	Curcumin	100-108	peroxiredoxin 6	Mus musculus	213-218
23830979-7	2013	injection, ELP-curcumin conjugates underwent a thermally triggered soluble-insoluble phase transition, leading to in situ formation of a depot that released curcumin over 4days post-injection and decreased plasma AUC 7-fold.	Curcumin	15-23	diazepam binding inhibitor-like 5	Mus musculus	11-14
26956814-7	2016	When anti-TfR mAb and curcumin were used simultaneously, a synergistic effect was detected in relation to tumor growth inhibition and the induction of cells necrosis.	Curcumin	22-30	transferrin receptor	Homo sapiens	10-13
26956814-8	2016	CONCLUSION: These results provided a potential role of anti-TfR mAb-containing curcumin in the treatment for gliomas.	Curcumin	79-87	transferrin receptor	Homo sapiens	60-63
23616010-7	2013	Suppression of c-Jun/AP-1 activation using a natural inhibitor curcumin decreased the expression of caspase-3, MMP-9, and TF, as well as the proliferation and migration of SW620 cells induced by PAR2-AP or FVIIa.	Curcumin	63-71	F2R like trypsin receptor 1	Homo sapiens	195-199
23239418-4	2013	Curcumin could favorably affect all leading components of metabolic syndrome including insulin resistance, obesity, hypertriglyceridemia, decreased HDL-C and hypertension, and prevent the deleterious complications of MetS including diabetes and cardiovascular disease.	Curcumin	0-8	ETS variant transcription factor 3	Homo sapiens	217-221
23239418-5	2013	Owing to its antioxidant and anti-inflammatory properties, curcumin can also exert several pleiotropic effects and improve endothelial dysfunction, adipokine imbalances, and hyperuricemia which usually accompany MetS.	Curcumin	59-67	ETS variant transcription factor 3	Homo sapiens	212-216
23239418-7	2013	This review seeks to briefly summarize the ample scientific evidence that supports the therapeutic efficacy of curcumin, at least as an adjunctive treatment, in patients with MetS.	Curcumin	111-119	ETS variant transcription factor 3	Homo sapiens	175-179
26729105-6	2015	Furthermore, curcumin treatment decreased glial scar formation by decreasing the levels of MIP1alpha, IL-2, and RANTES production and by decreasing NF-kappaB activity.	Curcumin	13-21	C-C motif chemokine ligand 3	Rattus norvegicus	91-100
23222814-6	2013	However, simultaneous exposure to BPA and the polyphenol, curcumin, partially or fully reduced the spectrum of effects associated with BPA alone, including mTOR pathway proteins (AKT1, RPS6, pRPS6 and 4EBP1).	Curcumin	58-66	ribosomal protein S6	Homo sapiens	185-189
23506591-2	2013	Curcumin can alleviate the symptom of inflammatory pain by inhibiting the production and release of interleukin and tumor necrosis factor.	Curcumin	0-8	tumor necrosis factor-like	Rattus norvegicus	100-137
23415873-6	2013	The treatment of T cells with curcumin induced the unfolded protein response (UPR) signaling pathway, initiated by the phosphorylation of PERK and IRE1.	Curcumin	30-38	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	147-151
23389039-8	2013	Ingenuity Pathway Analysis also indicated that curcumin and miR-34 are upstream regulators of histone-modifying enzymes; future studies will seek to validate these results and examine the role of curcumin and miR-34 in leukemia.	Curcumin	47-55	microRNA 34a	Homo sapiens	209-215
23389039-8	2013	Ingenuity Pathway Analysis also indicated that curcumin and miR-34 are upstream regulators of histone-modifying enzymes; future studies will seek to validate these results and examine the role of curcumin and miR-34 in leukemia.	Curcumin	196-204	microRNA 34a	Homo sapiens	60-66
23182879-0	2013	Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells.	Curcumin	111-119	eukaryotic elongation factor 2 kinase	Homo sapiens	52-57
23182879-6	2013	Moreover, inhibiting EEF2K by either RNAi or NH125, a small molecule inhibitor of the enzyme, rendered tumor cells more sensitive to curcumin and velcade, two anticancer agents that possess ER stress-inducing action.	Curcumin	133-141	eukaryotic elongation factor 2 kinase	Homo sapiens	21-26
22948514-0	2013	Curcumin protects against concanavalin A-induced hepatitis in mice through inhibiting the cytoplasmic translocation and expression of high mobility group box 1.	Curcumin	0-8	high mobility group box 1	Mus musculus	134-159
22948514-4	2013	Enzyme linked immunosorbent assay (ELISA) results showed that serum levels of high mobility group box 1 (HMGB1) increased at 4 h and reached its peak value at 12 h after challenge with ConA; but this increase was significantly inhibited by curcumin.	Curcumin	240-248	high mobility group box 1	Mus musculus	78-103
22948514-4	2013	Enzyme linked immunosorbent assay (ELISA) results showed that serum levels of high mobility group box 1 (HMGB1) increased at 4 h and reached its peak value at 12 h after challenge with ConA; but this increase was significantly inhibited by curcumin.	Curcumin	240-248	high mobility group box 1	Mus musculus	105-110
22948514-5	2013	Furthermore, curcumin significantly decreased the HMGB1 translocation from nucleus to cytoplasm of hepatocytes in ConA-induced mice.	Curcumin	13-21	high mobility group box 1	Mus musculus	50-55
22948514-6	2013	The levels of HMGB1 mRNA and protein expression in the liver were also significantly lowered in curcumin-treated mice.	Curcumin	96-104	high mobility group box 1	Mus musculus	14-19
22948514-8	2013	In conclusion, the results indicated that curcumin protected against ConA-induced hepatitis in mice; and the beneficial effects may be partly through inhibition of HMGB1 translocation in hepatocytes, release into the plasma and expression in livers.	Curcumin	42-50	high mobility group box 1	Mus musculus	164-169
22729592-6	2013	Curcumin supplementation increased plasma concentrations of angiogenic factors angiogenin (p &lt; 0.05), basic fibroblast growth factor (p &lt; 0.05) and vascular endothelial growth factor (p &lt; 0.05), as well as inflammatory cytokines interleukin-1beta (p &lt; 0.05) and monocyte chemotactic protein-1 (p &lt; 0.05), compared to the controls.	Curcumin	0-8	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	79-89
22729592-6	2013	Curcumin supplementation increased plasma concentrations of angiogenic factors angiogenin (p &lt; 0.05), basic fibroblast growth factor (p &lt; 0.05) and vascular endothelial growth factor (p &lt; 0.05), as well as inflammatory cytokines interleukin-1beta (p &lt; 0.05) and monocyte chemotactic protein-1 (p &lt; 0.05), compared to the controls.	Curcumin	0-8	fibroblast growth factor 2	Mus musculus	105-135
23762140-6	2013	In addition, curcumin suppressed neuroinflammatory response by decreasing inflammatory mediators, such as IL-1 beta , TNF- alpha , PGE2, NO, COX-2, and iNOS induced by cerebral ischemia of rats.	Curcumin	13-21	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	141-146
23520547-0	2013	Depletion of cellular iron by curcumin leads to alteration in histone acetylation and degradation of Sml1p in Saccharomyces cerevisiae.	Curcumin	30-38	ribonucleotide reductase inhibiting protein SML1	Saccharomyces cerevisiae S288C	101-106
23520547-5	2013	Additionally, treatment of curcumin caused the iron starvation induced expression of FET3, FRE1 genes.	Curcumin	27-35	ferroxidase FET3	Saccharomyces cerevisiae S288C	85-89
23520547-6	2013	We also demonstrated that curcumin induces degradation of Sml1p, a ribonucleotide reductase inhibitor involved in regulating dNTPs production.	Curcumin	26-34	ribonucleotide reductase inhibiting protein SML1	Saccharomyces cerevisiae S288C	58-63
23544048-8	2013	Further, the effect of curcumin on alpha-SMA, PAI-1, E-cadherin, TbetaR I and TbetaR II were reversed by ERK inhibitor U0126 or PPARgamma inhibitor BADGE, or PPARgamma shRNA.	Curcumin	23-31	transforming growth factor beta receptor 2	Homo sapiens	78-87
23457487-5	2013	Mechanistically, curcumin reduced the expression of positive regulators of DNMT1, p65 and Sp1, which correlated with a reduction in binding of these transcription factors to the DNMT1 promoter in AML cell lines.	Curcumin	17-25	RELA proto-oncogene, NF-kB subunit	Homo sapiens	82-85
23063543-0	2012	Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice.	Curcumin	0-8	high mobility group box 1	Mus musculus	18-23
24397136-0	2013	[Effect of curcumin on calcitionin gene related peptide expression after spinal cord injury in rats].	Curcumin	11-19	calcitonin-related polypeptide alpha	Rattus norvegicus	23-55
24397136-1	2013	OBJECTIVE: To investigate the effect of curcumin on calcitionin gene related peptide (CGRP) expression after spinal cord injury (SCI) in rats.	Curcumin	40-48	calcitonin-related polypeptide alpha	Rattus norvegicus	52-84
24397136-1	2013	OBJECTIVE: To investigate the effect of curcumin on calcitionin gene related peptide (CGRP) expression after spinal cord injury (SCI) in rats.	Curcumin	40-48	calcitonin-related polypeptide alpha	Rattus norvegicus	86-90
24397136-9	2013	Immunohistochemical staining results showed that the CGRP positive cells of sham-operation group was significantly more than those of the other 3 groups, and the CGRP positive cells of high-dose curcumin group were significantly more than those of low-dose curcumin group at each time point (P &lt; 0.05); the CGRP positive cells of low- and high-dose curcumin groups were significantly more than those of NS group at 3, 7, 14, and 21 days after SCI (P &lt; 0.05).	Curcumin	195-203	calcitonin-related polypeptide alpha	Rattus norvegicus	162-166
24397136-9	2013	Immunohistochemical staining results showed that the CGRP positive cells of sham-operation group was significantly more than those of the other 3 groups, and the CGRP positive cells of high-dose curcumin group were significantly more than those of low-dose curcumin group at each time point (P &lt; 0.05); the CGRP positive cells of low- and high-dose curcumin groups were significantly more than those of NS group at 3, 7, 14, and 21 days after SCI (P &lt; 0.05).	Curcumin	195-203	calcitonin-related polypeptide alpha	Rattus norvegicus	162-166
24397136-10	2013	Western blot assay results showed that the CGRP protein expressed at each time point after SCI in sham-operation group; the CGRP protein expression gradually decrease with time passing in NS group; but the CGRP protein expression gradually increased with time passing in low- and high-dose curcumin groups, and reached the peak at 14 days, then maintained a high level.	Curcumin	290-298	calcitonin-related polypeptide alpha	Rattus norvegicus	43-47
24397136-11	2013	CONCLUSION: After SCI in rats, 30 mg/kg curcumin can improve rats" motor function, and 100 mg/kg curcumin effect is more obvious, especially in promoting the expression of CGRP.	Curcumin	97-105	calcitonin-related polypeptide alpha	Rattus norvegicus	172-176
23845850-7	2013	The intrahepatic gene or protein expression of hypoxia-inducible factor-1alpha, VEGFR-1, placental growth factor, and cyclooxygenase-2 decreased with treatment with curcumin in fibrotic rats.	Curcumin	165-173	Fms related receptor tyrosine kinase 1	Rattus norvegicus	80-87
23845850-7	2013	The intrahepatic gene or protein expression of hypoxia-inducible factor-1alpha, VEGFR-1, placental growth factor, and cyclooxygenase-2 decreased with treatment with curcumin in fibrotic rats.	Curcumin	165-173	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	118-134
23901044-4	2013	The addition of curcumin restored the expression of gamma-glutamylcysteine synthetase, reactive oxygen species, and reactive nitrogen species levels but had no effect on the decrease of glutathione (GSH) and on the elevation of protein carbonyls.	Curcumin	16-24	glutamate-cysteine ligase catalytic subunit	Homo sapiens	52-85
26672753-8	2015	Curcumin also increased ERK 1/2 phosphorylation, while inhibiting ERK by U0126 attenuated the curcumin-induced up-regulation of BK protein expression.	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	24-31
26633653-4	2015	However, the mZac1-enhanced AP-1 transcriptional activity was suppressed by curcumin, indicating the anti-inflammatory property of this botanical agent and is exhibited by blocking the AP-1-mediated cross-talk between PSORS1 and PSORS4.	Curcumin	76-84	pleiomorphic adenoma gene-like 1	Mus musculus	13-18
23132777-0	2013	Curcumin serves as a human kv1.3 blocker to inhibit effector memory T lymphocyte activities.	Curcumin	0-8	potassium voltage-gated channel subfamily A member 3	Homo sapiens	27-32
23132777-5	2013	In the present study, we examined the effect of curcumin on human Kv1.3 (hKv1.3) channels stably expressed in HEK-293 cells and its ability to inhibit proliferation and cytokine secretion of T(EM) cells isolated from patients with MS or RA.	Curcumin	48-56	potassium voltage-gated channel subfamily A member 3	Homo sapiens	66-71
23132777-5	2013	In the present study, we examined the effect of curcumin on human Kv1.3 (hKv1.3) channels stably expressed in HEK-293 cells and its ability to inhibit proliferation and cytokine secretion of T(EM) cells isolated from patients with MS or RA.	Curcumin	48-56	potassium voltage-gated channel subfamily A member 3	Homo sapiens	73-79
23132777-6	2013	Curcumin exhibited a direct blockage of hKv1.3 channels in a time-dependent and concentration-dependent manner.	Curcumin	0-8	potassium voltage-gated channel subfamily A member 3	Homo sapiens	40-46
23132777-9	2013	Our findings demonstrate that curcumin is able to inhibit proliferation and proinflammatory cytokine secretion of T(EM) cells probably through inhibition of hKv1.3 channels, which contributes to the potency of curcumin for the treatment of autoimmune diseases.	Curcumin	30-38	potassium voltage-gated channel subfamily A member 3	Homo sapiens	157-163
23132777-9	2013	Our findings demonstrate that curcumin is able to inhibit proliferation and proinflammatory cytokine secretion of T(EM) cells probably through inhibition of hKv1.3 channels, which contributes to the potency of curcumin for the treatment of autoimmune diseases.	Curcumin	210-218	potassium voltage-gated channel subfamily A member 3	Homo sapiens	157-163
23812632-8	2013	Curcumin effectively blocked hyperoxia-induced lung injury based on systematic analysis of markers for lung injury (apoptosis, Bcl-2/Bax, collagen III, fibronectin, vimentin, calponin, and elastin-related genes) and lung morphology (radial alveolar count and alveolar septal thickness).	Curcumin	0-8	vimentin	Rattus norvegicus	165-173
26633653-4	2015	However, the mZac1-enhanced AP-1 transcriptional activity was suppressed by curcumin, indicating the anti-inflammatory property of this botanical agent and is exhibited by blocking the AP-1-mediated cross-talk between PSORS1 and PSORS4.	Curcumin	76-84	PSORS4	Homo sapiens	229-235
23812632-9	2013	Mechanistically, curcumin prevented the hyperoxia-induced increases in cleaved caspase-3 and the phosphorylation of Erk1/2.	Curcumin	17-25	mitogen activated protein kinase 3	Rattus norvegicus	116-122
23812632-10	2013	Molecular effects of curcumin, both structural and cytoprotective, suggest that its actions against hyperoxia-induced lung injury are mediated via Erk1/2 activation and that it is a potential intervention against BPD.	Curcumin	21-29	mitogen activated protein kinase 3	Rattus norvegicus	147-153
26395192-5	2015	Curcumin significantly alleviated fructose-induced podocyte injury and proteinuria, miR-206 low-expression, protein tyrosine phosphatase 1B (PTP1B) overexpression, as well as downregulation of insulin receptor, insulin receptor substrate 1, caveolin-1, protein kinase B, and extracellular signal-regulated kinases 1 and 2 phosphorylation in kidney cortex or glomeruli of fructose-fed rats.	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	275-321
26414495-10	2015	Curcumin, DMC, and BDMC decreased the active form of PKCdelta protein stimulated by PMA in THP-1 cells.	Curcumin	0-8	protein kinase C delta	Homo sapiens	53-61
23665290-0	2013	Curcumin ameliorates memory deficits via neuronal nitric oxide synthase in aged mice.	Curcumin	0-8	nitric oxide synthase 1, neuronal	Mus musculus	41-71
23665290-3	2013	The present study attempts to investigate the effects of curcumin on memory decline of aged mice with a focus upon the possible contribution of the neuronal nitric oxide synthase (nNOS)/nitric oxide (NO) pathway in the memory amelioration effect of curcumin.	Curcumin	249-257	nitric oxide synthase 1, neuronal	Mus musculus	148-178
23665290-3	2013	The present study attempts to investigate the effects of curcumin on memory decline of aged mice with a focus upon the possible contribution of the neuronal nitric oxide synthase (nNOS)/nitric oxide (NO) pathway in the memory amelioration effect of curcumin.	Curcumin	249-257	nitric oxide synthase 1, neuronal	Mus musculus	180-184
23665290-5	2013	Immunoblotting revealed that chronic treatment of curcumin increased nNOS expression in the prefrontal cortex, amygdala and hippocampus, as well as the enhancement of nNOS activity and NO concentration.	Curcumin	50-58	nitric oxide synthase 1, neuronal	Mus musculus	69-73
23665290-5	2013	Immunoblotting revealed that chronic treatment of curcumin increased nNOS expression in the prefrontal cortex, amygdala and hippocampus, as well as the enhancement of nNOS activity and NO concentration.	Curcumin	50-58	nitric oxide synthase 1, neuronal	Mus musculus	167-171
23665290-7	2013	Furthermore, inhibition of nNOS synthase by 7-NI also prevented the memory improvement effects of curcumin in aged mice.	Curcumin	98-106	nitric oxide synthase 1, neuronal	Mus musculus	27-31
23665290-8	2013	Taken together, the results of the present study suggest that the amelioration of memory deficits by curcumin in aged mice was mediated, at least in part, by activating the nNOS activity in specific brain regions.	Curcumin	101-109	nitric oxide synthase 1, neuronal	Mus musculus	173-177
22883304-1	2012	In this study, curcumin derivatives salicylidenecurcumin (CD1) and benzalidenecurcumin (CD2)] were prepared, and their biological activity was compared in in vitro selenite-induced cataract model.	Curcumin	15-23	CD1d1 molecule	Rattus norvegicus	58-61
22883304-6	2012	These results indicated that curcumin and its derivatives--CD1 and CD2--are beneficial against selenite-induced cataract in vitro.	Curcumin	29-37	CD1d1 molecule	Rattus norvegicus	59-62
22324466-0	2012	Curcumin inhibits thrombin-stimulated connective tissue growth factor (CTGF/CCN2) production through c-Jun NH2-terminal kinase suppression in human gingival fibroblasts.	Curcumin	0-8	cellular communication network factor 2	Homo sapiens	71-75
22324466-0	2012	Curcumin inhibits thrombin-stimulated connective tissue growth factor (CTGF/CCN2) production through c-Jun NH2-terminal kinase suppression in human gingival fibroblasts.	Curcumin	0-8	cellular communication network factor 2	Homo sapiens	76-80
22324466-5	2012	This study investigates the signaling pathway of thrombin-induced CCN2 expression and inhibition of CCN2 expression by curcumin.	Curcumin	119-127	cellular communication network factor 2	Homo sapiens	100-104
22324466-10	2012	Curcumin dose dependently inhibited thrombin-induced CCN2 expression through JNK suppression in HGFs.	Curcumin	0-8	cellular communication network factor 2	Homo sapiens	53-57
22324466-12	2012	Curcumin could effectively inhibit CCN2 expression through JNK suppression.	Curcumin	0-8	cellular communication network factor 2	Homo sapiens	35-39
23347386-7	2013	Mice treated with curcumin had a significant reduction in the number of splenic CD19(+) B cells and the ratio of CD19 : CD3 cells (P &lt; 0 05) with no change in the T-cell population.	Curcumin	18-26	CD19 antigen	Mus musculus	80-84
25331984-6	2015	METHODS: Using a transgenic mouse model of gastric cancer in which beta-catenin, cyclooxygenase 2, and microsomal prostaglandin E synthase 1 activation is induced, we examined a curcumin analog with the most enhanced potential for treating gastric cancer through oral administration.	Curcumin	178-186	prostaglandin-endoperoxide synthase 2	Mus musculus	81-97
23347386-7	2013	Mice treated with curcumin had a significant reduction in the number of splenic CD19(+) B cells and the ratio of CD19 : CD3 cells (P &lt; 0 05) with no change in the T-cell population.	Curcumin	18-26	CD19 antigen	Mus musculus	113-117
23609161-0	2013	Curcumin inhibits TGFbeta1-induced CCN2 via Src, JNK, and Smad3 in gingiva.	Curcumin	0-8	cellular communication network factor 2	Homo sapiens	35-39
25890434-16	2015	To our knowledge, this is the first report showing reduction in HES-1 expression via protein analysis after treatment with curcumin.	Curcumin	123-131	hes family bHLH transcription factor 1	Homo sapiens	64-69
23609161-0	2013	Curcumin inhibits TGFbeta1-induced CCN2 via Src, JNK, and Smad3 in gingiva.	Curcumin	0-8	SMAD family member 3	Homo sapiens	58-63
23609161-8	2013	We further found that curcumin significantly abrogated the TGFbeta1-induced CCN2 in HGFs by inhibiting the phosphorylations of Src, JNK, and Smad3.	Curcumin	22-30	cellular communication network factor 2	Homo sapiens	76-80
23442673-3	2012	Moreover, curcumin regulated urate transport-related proteins and inhibited activation of the JAK2-STAT3 cascade and overexpression of SOCS3 and TGF-beta1 in the kidneys of fructose-fed rats.	Curcumin	10-18	suppressor of cytokine signaling 3	Rattus norvegicus	135-140
23017833-5	2012	Curcumin suppressed the activation of NF-kappaB via the inhibition of IkappaBalpha phosphorylation, and downregulated the expressions of Bcl-2 and CyclinD1 in ESCC cell lines.	Curcumin	0-8	cyclin D1	Homo sapiens	147-155
23609161-8	2013	We further found that curcumin significantly abrogated the TGFbeta1-induced CCN2 in HGFs by inhibiting the phosphorylations of Src, JNK, and Smad3.	Curcumin	22-30	SMAD family member 3	Homo sapiens	141-146
26600714-9	2015	In addition, curcumin increased Nrf2 activation and anti-oxidative genes expressions such as NQO1, HO-1, and SOD through inducing extracellular signal-regulated kinase (ERK) and p38 phosphorylation.	Curcumin	13-21	mitogen-activated protein kinase 14	Mus musculus	178-181
23890132-9	2013	Curcumin increased Caspase-3 activity and decreased trypsin activity, while inhibited nuclear factor-kappa (NF-kappaB) at all time points (P &lt; 0.05) and moreover reduced activator protein-1 (AP-1).	Curcumin	0-8	caspase 3	Rattus norvegicus	19-28
23890132-9	2013	Curcumin increased Caspase-3 activity and decreased trypsin activity, while inhibited nuclear factor-kappa (NF-kappaB) at all time points (P &lt; 0.05) and moreover reduced activator protein-1 (AP-1).	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	173-192
26600714-10	2015	CONCLUSION: Our data suggested that curcumin protected the liver from chronic-ethanol induced injury through attenuating oxidative stress, at least partially, through ERK/p38/Nrf2-mediated anti-oxidant signaling pathways.	Curcumin	36-44	mitogen-activated protein kinase 14	Mus musculus	171-174
23890132-9	2013	Curcumin increased Caspase-3 activity and decreased trypsin activity, while inhibited nuclear factor-kappa (NF-kappaB) at all time points (P &lt; 0.05) and moreover reduced activator protein-1 (AP-1).	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	194-198
23890132-12	2013	CONCLUSIONS: In conclusion, curcumin reduced tissue injury, trypsin activation and inhibited NF-kappaB and AP-1.	Curcumin	28-36	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	107-111
26677679-15	2015	Therefore, curcumin might inhibit the occurrence and developing of lung fibrosis through blocking PPAR-gamma/PDGF-beta signaling pathway.	Curcumin	11-19	peroxisome proliferator activated receptor gamma	Mus musculus	98-108
23778405-11	2013	The expression of the multidrug resistance protein 1 and survivin genes was significantly reduced in xenografts of curcumin-treated mice and mice treated with both curcumin and vincristine relative to control mice.	Curcumin	115-123	baculoviral IAP repeat-containing 5	Mus musculus	57-65
23778405-11	2013	The expression of the multidrug resistance protein 1 and survivin genes was significantly reduced in xenografts of curcumin-treated mice and mice treated with both curcumin and vincristine relative to control mice.	Curcumin	164-172	baculoviral IAP repeat-containing 5	Mus musculus	57-65
22445558-6	2012	RESULTS: The specific activity of N-acetyl-beta-d-glucosaminidase in liver of diabetic rats was decreased when compared to control rats and was ameliorated with curcumin and quercetin treatment by 67% and 78%, respectively.	Curcumin	161-169	O-GlcNAcase	Rattus norvegicus	34-65
26116834-10	2015	Real time PCR analysis showed that exosomes, released in the plasma of the Curcumin-treated mice, were enriched in miR-21 with respect control.	Curcumin	75-83	microRNA 21a	Mus musculus	115-121
23259320-11	2012	Moreover, endometriotic progression was directly linked with increased MMP-2/TIMP-2 ratio which was delayed by curcumin pretreatment.	Curcumin	111-119	tissue inhibitor of metalloproteinase 2	Mus musculus	77-83
22290509-6	2013	The decreased cell viability observed in SkBr3 cells when curcumin was combined with TSA led to a G0/G1 cell cycle arrest and increased p21 and p27, and decreased Cyclin D1 protein expression.	Curcumin	58-66	cyclin D1	Homo sapiens	163-172
26102194-0	2015	Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells.	Curcumin	0-8	nuclear receptor subfamily 1 group H member 3	Homo sapiens	89-97
26102194-4	2015	Curcumin activated AMP-activated protein kinase (AMPK) and SIRT1, and then activated LXRalpha in THP-1 macrophage-derived foam cells.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	19-47
26102194-4	2015	Curcumin activated AMP-activated protein kinase (AMPK) and SIRT1, and then activated LXRalpha in THP-1 macrophage-derived foam cells.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	49-53
26102194-5	2015	Inhibiting AMPK/SIRT1 activity by its specific inhibitor or by small interfering RNA could inhibit LXRalpha activation and abolish curcumin-induced ABCA1 expression and cholesterol efflux.	Curcumin	131-139	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	11-15
26102194-6	2015	Thus, curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through activating AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells.	Curcumin	6-14	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	95-99
26102194-6	2015	Thus, curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through activating AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells.	Curcumin	6-14	nuclear receptor subfamily 1 group H member 3	Homo sapiens	106-114
22867086-0	2012	Quercetin, resveratrol, and curcumin are indirect activators of the aryl hydrocarbon receptor (AHR).	Curcumin	28-36	aryl hydrocarbon receptor	Homo sapiens	68-93
26047311-6	2015	Under LPS conditions, curcumin reduced the microglial proinflammatory markers iNOS and tumor necrosis factor, but increased the anti-inflammatory cytokine IL4.	Curcumin	22-30	interleukin 4	Rattus norvegicus	155-158
22867086-0	2012	Quercetin, resveratrol, and curcumin are indirect activators of the aryl hydrocarbon receptor (AHR).	Curcumin	28-36	aryl hydrocarbon receptor	Homo sapiens	95-98
22867086-2	2012	The aim of this study was to investigate whether quercetin (QUE), resveratrol (RES), and curcumin (CUR) interfere with the metabolic degradation of the suggested endogenous AHR ligand 6-formylindolo[3,2-b]carbazole (FICZ) and thereby indirectly activate the AHR.	Curcumin	89-97	aryl hydrocarbon receptor	Homo sapiens	173-176
26622667-8	2015	Combined treatment with ERK inhibitor U0126 and curcumin resulted in a synergistic reduction in MMP-2/-9 expression; the invasive capabilities of HEC-1B cells were also inhibited.	Curcumin	48-56	matrix metallopeptidase 2	Homo sapiens	96-104
22867086-2	2012	The aim of this study was to investigate whether quercetin (QUE), resveratrol (RES), and curcumin (CUR) interfere with the metabolic degradation of the suggested endogenous AHR ligand 6-formylindolo[3,2-b]carbazole (FICZ) and thereby indirectly activate the AHR.	Curcumin	89-97	aryl hydrocarbon receptor	Homo sapiens	258-261
26622667-9	2015	In conclusion, curcumin inhibits tumor cell migration and invasion by reducing the expression and activity of MMP-2/9 via the suppression of the ERK signaling pathway, suggesting that curcumin is a potential therapeutic agent for EC.	Curcumin	15-23	matrix metallopeptidase 2	Homo sapiens	110-115
22921746-6	2012	Also, curcumin strongly repressed the TPA-induced phosphorylation of p38 and JNK and inhibited TPA-induced translocation of PKCalpha from the cytosol to the membrane, but did not affect the translocation of PKCdelta.	Curcumin	6-14	protein kinase C delta	Homo sapiens	207-215
26622667-9	2015	In conclusion, curcumin inhibits tumor cell migration and invasion by reducing the expression and activity of MMP-2/9 via the suppression of the ERK signaling pathway, suggesting that curcumin is a potential therapeutic agent for EC.	Curcumin	184-192	matrix metallopeptidase 2	Homo sapiens	110-115
26305906-7	2015	Curcumin sensitized BCSCs through a reduction in the expression of ATP-binding cassette (ABC) transporters ABCG2 and ABCC1.	Curcumin	0-8	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	67-87
22705585-5	2012	In particular, depending on the dose used, we have observed that curcumin is able to induce both HSP27 and alphaB-crystallin, to reduce expression of both RNA and protein of endogenous GFAP, to induce autophagy and, finally, to rescue the filamentous organization of the GFAP mutant protein, thus suggesting a role of this spice in counteracting the pathogenic effects of GFAP mutations.	Curcumin	65-73	heat shock protein family B (small) member 2	Homo sapiens	97-102
26305906-7	2015	Curcumin sensitized BCSCs through a reduction in the expression of ATP-binding cassette (ABC) transporters ABCG2 and ABCC1.	Curcumin	0-8	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	89-92
22705896-4	2012	This study investigates whether curcumin inhibits Skp2-mediated p27 ubiquitination in Her2/Skp2-overexpressing cancer cell lines (MDA-MB-231/Her2 cells).	Curcumin	32-40	S-phase kinase associated protein 2	Homo sapiens	50-54
22705896-4	2012	This study investigates whether curcumin inhibits Skp2-mediated p27 ubiquitination in Her2/Skp2-overexpressing cancer cell lines (MDA-MB-231/Her2 cells).	Curcumin	32-40	S-phase kinase associated protein 2	Homo sapiens	91-95
22705896-6	2012	A low dose of curcumin increases p27 and decreases Skp2, Her2, Cyclin E, CDK kinases in a time- and dose-dependent manner, suggesting that p27, Skp2 and Her2 may be involved in the growth inhibition in MDA-MB-231/Her2 cells induced by curcumin.	Curcumin	14-22	S-phase kinase associated protein 2	Homo sapiens	51-55
26299580-5	2015	Mechanistic studies showed that anticancer activity of curcumin is associated with decrease in migration of HNSCC and associated angiogenesis through activating of intrinsic apoptotic pathway (caspase-9) and extrinsic apoptotic pathway (caspase-8).	Curcumin	55-63	caspase 8	Homo sapiens	237-246
22705896-6	2012	A low dose of curcumin increases p27 and decreases Skp2, Her2, Cyclin E, CDK kinases in a time- and dose-dependent manner, suggesting that p27, Skp2 and Her2 may be involved in the growth inhibition in MDA-MB-231/Her2 cells induced by curcumin.	Curcumin	14-22	S-phase kinase associated protein 2	Homo sapiens	144-148
22705896-7	2012	However, higher doses of curcumin produce a dose-dependent apoptotic death in MDA-MB-231/Her2 cells, which is related to cleaved forms of PARP and caspase 3.	Curcumin	25-33	collagen type XI alpha 2 chain	Homo sapiens	138-142
22705896-8	2012	The findings indicate that curcumin is of potential value for the chemoprevention of breast cancer, especially in breast cancer with Skp2/Her2 overexpression.	Curcumin	27-35	S-phase kinase associated protein 2	Homo sapiens	133-137
22751848-10	2012	By contrast, obese mice treated with curcumin showed normalized mtDNA, NRF1 and Tfam gene expression, reduced hepatic nuclear factor-kappaB activities and levels of thiobarbituric acid reactive substances (TBARS) and restored mitochondrial oxidative metabolism and biogenesis.	Curcumin	37-45	transcription factor A, mitochondrial	Mus musculus	80-84
22653966-3	2012	Curcumin induces the activation of caspase-8, -2, and -9, alteration of mitochondrial membrane potential, release of cytochrome c, and activation of caspase-3 and concomitant PARP cleavage, but the addition of caspase inhibitors only partially blocked the curcumin-mediated apoptosis.	Curcumin	0-8	caspase 8	Homo sapiens	35-56
22653966-3	2012	Curcumin induces the activation of caspase-8, -2, and -9, alteration of mitochondrial membrane potential, release of cytochrome c, and activation of caspase-3 and concomitant PARP cleavage, but the addition of caspase inhibitors only partially blocked the curcumin-mediated apoptosis.	Curcumin	0-8	collagen type XI alpha 2 chain	Homo sapiens	175-179
26299580-6	2015	Our data demonstrating that anticancer activity of curcumin is linked to the activation of the ATM/CHK2 pathway and the inhibition of nuclear factor-kappaB.	Curcumin	51-59	checkpoint kinase 2	Homo sapiens	99-103
25979230-5	2015	Curcumin alone and in combination significantly reduced spheroid number in CRLM CSC models, and decreased the number of cells with high aldehyde dehydrogenase activity (ALDH(high)/CD133(-)).	Curcumin	0-8	prominin 1	Homo sapiens	180-185
25979230-6	2015	Addition of curcumin to oxaliplatin/5-FU enhanced anti-proliferative and pro-apoptotic effects in a proportion of patient-derived explants, whilst reducing expression of stem cell-associated markers ALDH and CD133.	Curcumin	12-20	prominin 1	Homo sapiens	208-213
26339673-0	2015	Curcumin therapy in a Plp1 transgenic mouse model of Pelizaeus-Merzbacher disease.	Curcumin	0-8	proteolipid protein (myelin) 1	Mus musculus	22-26
22796219-5	2012	We established that the aminoacid conjugates curcumin-isoleucine, curcumin-phenylalanine and curcumin-valine promote the constitutive alpha-secretase activity and increase ADAM10 immunoreactivity.	Curcumin	45-53	ADAM metallopeptidase domain 10	Homo sapiens	172-178
22498762-7	2012	The pro-apoptotic effect of curcumin resulted from the increased expression of TRAIL-R1/R2 and the decreased expression of anti-apoptotic proteins.	Curcumin	28-36	TNF receptor superfamily member 10a	Homo sapiens	79-87
22498762-8	2012	Our results indicate that both curcumin and TNF-alpha up-regulated the expression of TRAIL-R1/R2.	Curcumin	31-39	TNF receptor superfamily member 10a	Homo sapiens	85-93
22498762-9	2012	In addition, the expression of anti-apoptotic proteins (IAP1, IAP2, Bcl-X(L)) was up-regulated by TNF-alpha but suppressed by curcumin in HaCaT cells.	Curcumin	126-134	baculoviral IAP repeat containing 2	Homo sapiens	62-66
22498762-11	2012	As expected, curcumin inhibited TNF-alpha-induced activation of NF-kappaB, including NF-kappaB-P65.	Curcumin	13-21	RELA proto-oncogene, NF-kB subunit	Homo sapiens	85-98
26339673-6	2015	RESULTS: Curcumin improved the motor phenotype performance of Plp1 transgenic mice by 50% toward wild-type level and preserved myelinated axons by 35% when compared to Plp1 transgenic controls.	Curcumin	9-17	proteolipid protein (myelin) 1	Mus musculus	62-66
26339673-7	2015	Furthermore, curcumin reduced astrocytosis, microgliosis and lymphocyte infiltration in Plp1 transgenic mice.	Curcumin	13-21	proteolipid protein (myelin) 1	Mus musculus	88-92
26339673-9	2015	However, high glutathione levels indicating an oxidative misbalance in the white matter of Plp1 transgenic mice were restored by curcumin treatment.	Curcumin	129-137	proteolipid protein (myelin) 1	Mus musculus	91-95
22613224-4	2012	The SA-beta-galactosidase activation was observed both in p53+/+ and p53-/- cells, however the latter ones were less sensitive to the prosenescent activity of curcumin.	Curcumin	159-167	galactosidase beta 1	Homo sapiens	7-25
26339673-10	2015	INTERPRETATION: Curcumin may potentially serve as an antioxidant therapy of PMD caused by PLP1 gene duplication.	Curcumin	16-24	proteolipid protein (myelin) 1	Mus musculus	90-94
26305715-10	2015	Gain- or loss-of-function analyses revealed Nrf2 and FXR mediated the effect of curcumin on lipid deposition in hepatocytes, and curcumin modulated the expression of FXR mediated by Nrf2.	Curcumin	129-137	nuclear receptor subfamily 1 group H member 4	Homo sapiens	166-169
26305715-11	2015	Collectively, we drew a conclusion that curcumin attenuated ALD by modulating lipid deposition in hepatocytes via a Nrf2/FXR activation-dependent mechanism.	Curcumin	40-48	nuclear receptor subfamily 1 group H member 4	Homo sapiens	121-124
25944087-0	2015	Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13.	Curcumin	0-8	interleukin 4	Rattus norvegicus	57-61
22510010-0	2012	Effect of curcumin on miRNA expression in human Y79 retinoblastoma cells.	Curcumin	10-18	RB transcriptional corepressor 1	Homo sapiens	52-66
26037398-0	2015	Curcumin inhibits Ec109 cell growth via an AMPK-mediated metabolic switch.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	43-47
22387197-8	2012	Curcumin treatment of leukemic cells also downregulates the expression of the inhibitor of apoptosis proteins (IAPs), phospho-Akt, c-Myc, and cyclin D1.	Curcumin	0-8	cyclin D1	Homo sapiens	142-151
22648616-4	2012	In addition, curcumin decreased the protein expression of scavenger receptor class A (SR-A) but increased that of ATP-binding cassette transporter (ABC) A1 and had no effect on the protein expression of CD36, class B receptor type I (SR-BI), or ATP-binding cassette transporter G1 (ABCG1).	Curcumin	13-21	macrophage scavenger receptor 1	Mus musculus	86-90
22648616-5	2012	The downregulation of SR-A by curcumin was via ubiquitin-proteasome-calpain-mediated proteolysis.	Curcumin	30-38	macrophage scavenger receptor 1	Mus musculus	22-26
26037398-8	2015	Our results further indicated that the AMPK was required for curcumin-mediated down-regulation of glycolytic enzymes.	Curcumin	61-69	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	39-43
22648616-7	2012	Curcumin administration modulated the expression of SR-A, ABCA1, ABCG1, and SR-BI in aortas and retarded atherosclerosis in apoE-/- mice.	Curcumin	0-8	macrophage scavenger receptor 1	Mus musculus	52-56
26046466-0	2015	Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells.	Curcumin	0-8	S-phase kinase associated protein 2	Homo sapiens	89-93
22648616-7	2012	Curcumin administration modulated the expression of SR-A, ABCA1, ABCG1, and SR-BI in aortas and retarded atherosclerosis in apoE-/- mice.	Curcumin	0-8	scavenger receptor class B, member 1	Mus musculus	76-81
22648616-8	2012	CONCLUSION: Our findings suggest that inhibition of SR-A-mediated oxLDL uptake and promotion of ABCA1-dependent cholesterol efflux are two crucial events in suppression of cholesterol accumulation by curcumin in the transformation of macrophage foam cells.	Curcumin	200-208	macrophage scavenger receptor 1	Mus musculus	52-56
22298641-8	2012	Furthermore, we found that curcumin-induced activation of MAPK pathways was related to inhibition of the serine/threonine protein phosphatases 2A (PP2A) and 5 (PP5).	Curcumin	27-35	protein phosphatase 5 catalytic subunit	Homo sapiens	160-163
22298641-9	2012	Overexpression of PP2A or PP5 partially prevented curcumin-induced activation of JNK and Erk1/2 phosphorylation as well as cell death.	Curcumin	50-58	protein phosphatase 5 catalytic subunit	Homo sapiens	26-29
22298641-10	2012	The results suggest that curcumin induction of ROS activates MAPKs, at least partially by inhibiting PP2A and PP5, thereby leading to p53-independent apoptosis in tumor cells.	Curcumin	25-33	protein phosphatase 5 catalytic subunit	Homo sapiens	110-113
22449094-0	2012	Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells.	Curcumin	5-13	microRNA 15a	Homo sapiens	65-72
22449094-0	2012	Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cells.	Curcumin	5-13	microRNA 16-1	Homo sapiens	77-85
26046466-4	2015	Therefore, we aim to determine whether curcumin suppresses the Skp2 expression, leading to the inhibition of cell growth, invasion, induction of apoptosis, and cell cycle arrest.	Curcumin	39-47	S-phase kinase associated protein 2	Homo sapiens	63-67
22449094-6	2012	RESULTS: We found that pure curcumin upregulated the expression of miR-15a/16-1 and downregulated the expression of WT1 in leukemic cells and primary acute myeloid leukemia (AML) cells.	Curcumin	28-36	microRNA 15a	Homo sapiens	67-74
22449094-8	2012	These results reveal that curcumin induced-upregulation of miR-15a/16-1 is an early event upstream to downregulation of WT1.	Curcumin	26-34	microRNA 15a	Homo sapiens	59-66
22449094-9	2012	Furthermore, anti-miR-15a/16-1 oligonucleotides (AMO) partly reversed the downregulation of WT1 induced by pure curcumin in leukemic cells and AMO promoted the growth of curcumin treated-K562 and HL-60 cells.	Curcumin	112-120	microRNA 15a	Homo sapiens	18-25
22149945-5	2013	Curcumin release from CS-NPs was slowest at chitosan to TPP weight ratio of 3:1, with a significant retention (36%) at the end of 6 h. Adsorption isotherms of mucin on CS-NPs fitted both the Freundlich and Langmuir models, suggesting a monolayer-limited adsorption on heterogeneous sites with varied affinities.	Curcumin	0-8	LOC100508689	Homo sapiens	159-164
22149945-6	2013	Encapsulated curcumin exerted an influence on the adsorption of mucin due to H-bonding as well as pi-pi interactions between the phenolic moieties of curcumin and mucin.	Curcumin	13-21	LOC100508689	Homo sapiens	64-69
26046466-8	2015	Mechanistically, we defined that curcumin markedly down-regulated Skp2 expression and subsequently up-regulated p57 expression.	Curcumin	33-41	S-phase kinase associated protein 2	Homo sapiens	66-70
22149945-6	2013	Encapsulated curcumin exerted an influence on the adsorption of mucin due to H-bonding as well as pi-pi interactions between the phenolic moieties of curcumin and mucin.	Curcumin	13-21	LOC100508689	Homo sapiens	163-168
22149945-6	2013	Encapsulated curcumin exerted an influence on the adsorption of mucin due to H-bonding as well as pi-pi interactions between the phenolic moieties of curcumin and mucin.	Curcumin	150-158	LOC100508689	Homo sapiens	64-69
26046466-9	2015	Moreover, our results demonstrated that curcumin exerts its antitumor activity through inhibition of Skp2 pathway.	Curcumin	40-48	S-phase kinase associated protein 2	Homo sapiens	101-105
23364261-7	2013	Reinforced expression of Prdx6 in HT22 cells by curcumin reestablished survival signaling by reducing propagation of ROS and blunting ER stress signaling.	Curcumin	48-56	peroxiredoxin 6	Mus musculus	25-30
22449094-9	2012	Furthermore, anti-miR-15a/16-1 oligonucleotides (AMO) partly reversed the downregulation of WT1 induced by pure curcumin in leukemic cells and AMO promoted the growth of curcumin treated-K562 and HL-60 cells.	Curcumin	170-178	microRNA 15a	Homo sapiens	18-25
26046466-10	2015	Collectively, our findings suggest that targeting Skp2 by curcumin could be a promising therapeutic approach for glioma prevention and therapy.	Curcumin	58-66	S-phase kinase associated protein 2	Homo sapiens	50-54
22449094-10	2012	CONCLUSION: Thus, these data suggest for the first time that pure curcumin downregulated the expression of WT1 partly by upregulating the expression of miR-15a/16-1 in leukemic cells.	Curcumin	66-74	microRNA 15a	Homo sapiens	152-159
22449094-11	2012	miR-15a/16-1 mediated WT1 downregulation plays an important role in the anti-proliferation effect of curcumin in leukemic cells.	Curcumin	101-109	microRNA 15a	Homo sapiens	0-7
23364261-9	2013	We propose that using curcumin to reinforce the naturally occurring Prdx6 expression and attenuate ROS-based ER stress and NF-kappaB-mediated aberrant signaling improves cell survival and may provide an avenue to treat and/or postpone diseases associated with ROS or ER stress.	Curcumin	22-30	peroxiredoxin 6	Mus musculus	68-73
23224523-10	2013	Curcumin inhibited TGF-beta-induced Smad2/3 phosphorylation and transcription in H358 and A549 cells, but not in ACC-LC-176 cells.	Curcumin	0-8	SMAD family member 2	Homo sapiens	36-41
26171159-8	2015	Tumor protein p63, MYC-associated factor X and certain other genes associated with tumors act on a potential therapeutic target, while apolipoprotein B receptor and oxysterol-binding protein-like 7, and their signaling pathways may be involved in the cardioprotective effects of curcumin.	Curcumin	279-287	oxysterol binding protein like 7	Homo sapiens	165-197
23511143-12	2013	Moreover, curcumin treatment restored decreased ERK1/2 phosphorylation (p-ERK1/2) and inhibited overactive p38 (p-p38) after injuries, and the effect was reversed by a leptin-specific antibody or Ob-R blocker.	Curcumin	10-18	mitogen-activated protein kinase 3	Mus musculus	48-54
23511143-12	2013	Moreover, curcumin treatment restored decreased ERK1/2 phosphorylation (p-ERK1/2) and inhibited overactive p38 (p-p38) after injuries, and the effect was reversed by a leptin-specific antibody or Ob-R blocker.	Curcumin	10-18	mitogen-activated protein kinase 3	Mus musculus	74-80
23511143-12	2013	Moreover, curcumin treatment restored decreased ERK1/2 phosphorylation (p-ERK1/2) and inhibited overactive p38 (p-p38) after injuries, and the effect was reversed by a leptin-specific antibody or Ob-R blocker.	Curcumin	10-18	mitogen-activated protein kinase 14	Mus musculus	107-110
23511143-12	2013	Moreover, curcumin treatment restored decreased ERK1/2 phosphorylation (p-ERK1/2) and inhibited overactive p38 (p-p38) after injuries, and the effect was reversed by a leptin-specific antibody or Ob-R blocker.	Curcumin	10-18	mitogen-activated protein kinase 14	Mus musculus	114-117
23511143-13	2013	CONCLUSION: These data suggest that leptin and Ob-Rb-dependent ERK and p38 MAPK signaling pathways may be involved in curcumin protection against intestinal I/R injury, and leptin may be a potential target of curcumin in intestinal I/R injury and other related acute diseases.	Curcumin	118-126	mitogen-activated protein kinase 14	Mus musculus	71-74
22568037-0	2012	Identification of curcumin targets in neuroinflammatory pathways: molecular docking scores with GSK-3beta, p38 MAPK, COX, ICE and TACE enzymes.	Curcumin	18-26	glycogen synthase kinase 3 beta	Homo sapiens	96-105
22568037-0	2012	Identification of curcumin targets in neuroinflammatory pathways: molecular docking scores with GSK-3beta, p38 MAPK, COX, ICE and TACE enzymes.	Curcumin	18-26	cytochrome c oxidase subunit 8A	Homo sapiens	117-120
22568037-2	2012	The anti-inflammatory pathway of curcumin was identified through docking with of curcumin with various inflammation inducing enzymes like glycogen synthase kinase (GSK-3beta), p38 mitogen activated protein kinase (MAPK), COX, interleukin-1beta converting enzyme (ICE) and tumor necrosis factor-alpha converting enzyme (TACE).	Curcumin	33-41	glycogen synthase kinase 3 beta	Homo sapiens	164-173
22568037-2	2012	The anti-inflammatory pathway of curcumin was identified through docking with of curcumin with various inflammation inducing enzymes like glycogen synthase kinase (GSK-3beta), p38 mitogen activated protein kinase (MAPK), COX, interleukin-1beta converting enzyme (ICE) and tumor necrosis factor-alpha converting enzyme (TACE).	Curcumin	33-41	cytochrome c oxidase subunit 8A	Homo sapiens	221-224
22568037-2	2012	The anti-inflammatory pathway of curcumin was identified through docking with of curcumin with various inflammation inducing enzymes like glycogen synthase kinase (GSK-3beta), p38 mitogen activated protein kinase (MAPK), COX, interleukin-1beta converting enzyme (ICE) and tumor necrosis factor-alpha converting enzyme (TACE).	Curcumin	81-89	glycogen synthase kinase 3 beta	Homo sapiens	164-173
22568037-2	2012	The anti-inflammatory pathway of curcumin was identified through docking with of curcumin with various inflammation inducing enzymes like glycogen synthase kinase (GSK-3beta), p38 mitogen activated protein kinase (MAPK), COX, interleukin-1beta converting enzyme (ICE) and tumor necrosis factor-alpha converting enzyme (TACE).	Curcumin	81-89	cytochrome c oxidase subunit 8A	Homo sapiens	221-224
22568037-5	2012	The binding target GSK-3beta (-6.44) was found to be more selective for curcumin binding when compared with MAPK (-4.08), COX (-7.35), ICE (-4.02), TACE (-6.38) and their respective native ligand.	Curcumin	72-80	glycogen synthase kinase 3 beta	Homo sapiens	19-28
22568037-9	2012	These findings enabled us to identify the keto form of curcumin as a best choice of lead compound to target GSK-3beta.	Curcumin	55-63	glycogen synthase kinase 3 beta	Homo sapiens	108-117
22174410-6	2012	Nfe2 modulates JunD binding to the Gcm1 promoter via acetylation, as reducing JunD acetylation using the histone acetyltransferase inhibitor curcumin reverses the increased JunD DNA-binding activity observed in the absence of Nfe2.	Curcumin	141-149	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-19
22174410-6	2012	Nfe2 modulates JunD binding to the Gcm1 promoter via acetylation, as reducing JunD acetylation using the histone acetyltransferase inhibitor curcumin reverses the increased JunD DNA-binding activity observed in the absence of Nfe2.	Curcumin	141-149	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	78-82
25060836-6	2015	Curcumin treatment further reduced the blood glucose level (near normal); and accelerated the organ regeneration, enhanced VEGF/PECAM expression and decreased caspase expression level in the organs.	Curcumin	0-8	platelet/endothelial cell adhesion molecule 1	Mus musculus	128-133
22174410-6	2012	Nfe2 modulates JunD binding to the Gcm1 promoter via acetylation, as reducing JunD acetylation using the histone acetyltransferase inhibitor curcumin reverses the increased JunD DNA-binding activity observed in the absence of Nfe2.	Curcumin	141-149	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	78-82
22031851-9	2012	Nx animals had significantly elevated kidney levels of cytosolic PLA(2), calcium-independent intracellular PLA(2), COX 1, and COX 2, which were comparably reduced by curcumin and enalapril.	Curcumin	166-174	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	126-131
23422877-8	2013	Treatment of SAMP8 mice with curcumin improved MMP and ATP and restored mitochondrial fusion, probably by up-regulating nuclear factor PGC1alpha protein expression.	Curcumin	29-37	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	135-144
26105926-15	2013	IL-8 was inhibited up to 67% by the liposomal curcumin in human vaginal cell lines (End1/E6E7, Ect1/E6E7, VK2/E6E7) as compared to curcumin.	Curcumin	46-54	VPS11 core subunit of CORVET and HOPS complexes	Homo sapiens	84-88
25060836-8	2015	CONCLUSION: This study suggests that bone marrow transplantation and curcumin administration is an effective treatment in reversing the early onset effects of diabetes via the VEGF/PECAM signaling pathway.	Curcumin	69-77	platelet/endothelial cell adhesion molecule 1	Mus musculus	181-186
25858818-10	2015	Furthermore, we demonstrated that curcumin significantly inhibited the TGFbeta1-induced NOX4 protein expression in HGFs.	Curcumin	34-42	NADPH oxidase 4	Homo sapiens	88-92
22554269-8	2013	Curcumin may decrease alveolar bone loss in the experimental periodontitis rats via suppressing the expression of RANKL/RANK/OPG and its anti-inflammatory properties.	Curcumin	0-8	TNF superfamily member 11	Rattus norvegicus	114-119
23219912-7	2013	Immunofluorescence and Western blotting analyses demonstrated that H(2)O(2) treatment upregulated the expression of Notch1, Hes1, Caspase3, Bax and cytochrome c downregulated the expression of Bcl2, and treatment with curcumin reversed these effects.	Curcumin	218-226	hes family bHLH transcription factor 1	Homo sapiens	124-128
21419610-5	2012	When the exposure of explants to curcumin or quercetin was limited to the first 4-5 days of culture, the suppression of 35S-aggrecan loss was maintained in the extended culture period when the tissue was stimulated with either retinoic acid or IL-1alpha.	Curcumin	33-41	interleukin 1 alpha	Bos taurus	244-253
21419610-7	2012	Curcumin suppressed retinoic acid stimulated expression of ADAMTS-5, and both polyphenols suppressed basal expression of ADAMTS-5.	Curcumin	0-8	ADAM metallopeptidase with thrombospondin type 1 motif 5	Bos taurus	59-67
25858818-11	2015	Curcumin potentially qualifies as an agent to control GO by suppressing TGFbeta1-induced NOX4 expression in HGFs.	Curcumin	0-8	NADPH oxidase 4	Homo sapiens	89-93
25767494-3	2012	The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury.	Curcumin	24-32	caspase 3	Rattus norvegicus	166-175
25938627-5	2015	This study shows that curcumin downregulated Patched and Smoothened, two key elements in Hh signaling, but restored Hhip expression in rat liver with carbon tetrachloride-induced fibrosis and in cultured HSCs.	Curcumin	22-30	Hedgehog-interacting protein	Rattus norvegicus	116-120
22253518-6	2012	The nude mouse xenograft assay showed that EGCG and the combinations of curcumin, EGCG and lovastatin suppressed esophageal cancer cell growth and reduced the expression of Ki67, phosphorylated Erk1/2 and COX-2.	Curcumin	72-80	mitogen-activated protein kinase 3	Mus musculus	194-200
22253518-6	2012	The nude mouse xenograft assay showed that EGCG and the combinations of curcumin, EGCG and lovastatin suppressed esophageal cancer cell growth and reduced the expression of Ki67, phosphorylated Erk1/2 and COX-2.	Curcumin	72-80	prostaglandin-endoperoxide synthase 2	Mus musculus	205-210
22253518-10	2012	CONCLUSION: The combinations of curcumin, EGCG and lovastatin were able to suppress esophageal cancer cell growth in vitro and in nude mouse xenografts, these drugs also inhibited phosphorylated Erk1/2, c-Jun and COX-2 expression.	Curcumin	32-40	mitogen-activated protein kinase 3	Mus musculus	195-201
23380686-9	2013	The present study indicates beneficial effect of curcumin in diabetic rats by regulating the cholinergic, insulin receptor and GLUT-3 in the brainstem similar to the responses obtained with insulin therapy.	Curcumin	49-57	insulin receptor	Rattus norvegicus	106-122
23294827-7	2013	Peptides pulled down from this reaction were sequenced and it was determined that biotinylated curcumin bound hsp70, hsp90, 3-phosphoglycerate dehydrogenase, and a beta-actin variant.	Curcumin	95-103	phosphoglycerate dehydrogenase	Homo sapiens	124-156
22253518-10	2012	CONCLUSION: The combinations of curcumin, EGCG and lovastatin were able to suppress esophageal cancer cell growth in vitro and in nude mouse xenografts, these drugs also inhibited phosphorylated Erk1/2, c-Jun and COX-2 expression.	Curcumin	32-40	jun proto-oncogene	Mus musculus	203-208
25938627-6	2015	Curcumin also halted the nuclear translocation, DNA binding, and transcription activity of Gli1.	Curcumin	0-8	GLI family zinc finger 1	Rattus norvegicus	91-95
22253518-10	2012	CONCLUSION: The combinations of curcumin, EGCG and lovastatin were able to suppress esophageal cancer cell growth in vitro and in nude mouse xenografts, these drugs also inhibited phosphorylated Erk1/2, c-Jun and COX-2 expression.	Curcumin	32-40	prostaglandin-endoperoxide synthase 2	Mus musculus	213-218
22508043-5	2012	The combination of curcumin (10 muM) and trolox (10-50 muM) induced apoptosis of cancer cells as evidenced by PARP cleavage and caspase-3 activation.	Curcumin	19-27	collagen type XI alpha 2 chain	Homo sapiens	110-114
22875542-18	2013	On the other hand, pretreatment with curcumin significantly increased renal M6PRBP-1 and NEDD-4 expression.	Curcumin	37-45	perilipin 3	Mus musculus	76-84
25791922-4	2015	Curcumin treatment in the hippocampus or SH-SY5Y cells inhibited IRE1alpha and PERK phosphorylation with suppression of intracellular ROS production.	Curcumin	0-8	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	65-74
24381587-8	2013	Additionally, immunohistochemical analysis demonstrated that curcumin treatment markedly reduced cyclooxygenase-2 expression.	Curcumin	61-69	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	97-113
23325575-5	2013	Genes osr-1, sek-1, mek-1, skn-1, unc-43, sir-2.1, and age-1 are required for curcumin-mediated lifespan extension.	Curcumin	78-86	frayed	Drosophila melanogaster	6-11
22942754-5	2012	Western blot analyses showed that curcumin decreased the ionomycin-induced phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and synaptic vesicle-associated protein synapsin I, the main presynaptic target of ERK.	Curcumin	34-42	mitogen activated protein kinase 3	Rattus norvegicus	94-139
22942754-5	2012	Western blot analyses showed that curcumin decreased the ionomycin-induced phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and synaptic vesicle-associated protein synapsin I, the main presynaptic target of ERK.	Curcumin	34-42	mitogen activated protein kinase 3	Rattus norvegicus	141-147
25791922-9	2015	Immunohistochemistry showed that curcumin inhibited p-IRE1alpha, p-PERK and NLRP3 expression in hippocampus CA1 region.	Curcumin	33-41	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	54-63
26309547-11	2015	pcDNA3.1-GLUT1 transfected A549 cells exhibited resistance to curcumin"s anti-invasion effect by up-regulating expressions of GLUT2, MT1-MMP and MMP2.	Curcumin	62-70	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	126-131
25867253-5	2015	The Fas/FasL expressions in HHBD rats treated by curcumin were measured by immunohistochemical staining and western blotting.	Curcumin	49-57	Fas ligand	Rattus norvegicus	8-12
22156608-3	2012	Curcumins restore Abeta phagocytosis by peripheral blood mononuclear cells (PBMCs) from AD patients and Abeta clearance with upregulation of key genes including MGAT3, vitamin D receptor (VDR) and Toll-like receptors (TLRs).	Curcumin	0-9	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	161-166
22172229-6	2012	The expression levels of tumor necrosis factor-alpha, interleukin-6, and cyclooxygenase-2 (COX-2) mRNAs on the colonic mucosa of AOM-treated mice were significantly decreased by curcumin administration.	Curcumin	178-186	prostaglandin-endoperoxide synthase 2	Mus musculus	73-89
22172229-6	2012	The expression levels of tumor necrosis factor-alpha, interleukin-6, and cyclooxygenase-2 (COX-2) mRNAs on the colonic mucosa of AOM-treated mice were significantly decreased by curcumin administration.	Curcumin	178-186	prostaglandin-endoperoxide synthase 2	Mus musculus	91-96
22172229-7	2012	Dietary feeding with curcumin markedly activated AMP-activated kinase, decreased the expression of COX-2 protein, and inhibited nuclear factor-kappaB activity on the colonic mucosa of AOM-treated mice.	Curcumin	21-29	prostaglandin-endoperoxide synthase 2	Mus musculus	99-104
23689497-7	2013	Moreover, immunohistochemical investigations demonstrated that curcumin treatment markedly decreased expression of inducible nitric oxide synthase, nuclear factor-kappaB, and caspase-3.	Curcumin	63-71	caspase 3	Rattus norvegicus	175-184
23577194-0	2013	Hepatitis C virus core protein down-regulates p21(Waf1/Cip1) and inhibits curcumin-induced apoptosis through microRNA-345 targeting in human hepatoma cells.	Curcumin	74-82	microRNA 345	Homo sapiens	109-121
23577194-15	2013	Moreover, the core protein inhibited curcumin-induced apoptosis through p21(Waf1/Cip1)-targeting microRNA-345 in Huh7 cells.	Curcumin	37-45	microRNA 345	Homo sapiens	97-109
23437361-9	2013	In addition, curcumin also significantly inhibited the expression of alpha-smooth muscle actin and Tenascin-C, key markers of myofibroblast activation.	Curcumin	13-21	tenascin C	Mus musculus	99-109
23063543-8	2012	Furthermore, curcumin pretreatment dramatically suppressed the releasing of high-mobility group box-1 (HMGB1) in liver tissues.	Curcumin	13-21	high mobility group box 1	Mus musculus	76-101
25867253-8	2015	Curcumin intervention effectively reversed the Fas/FasL-mediated apoptosis and HHBD-induced brain edema.	Curcumin	0-8	Fas ligand	Rattus norvegicus	51-55
23063543-8	2012	Furthermore, curcumin pretreatment dramatically suppressed the releasing of high-mobility group box-1 (HMGB1) in liver tissues.	Curcumin	13-21	high mobility group box 1	Mus musculus	103-108
23063543-9	2012	These results suggest that curcumin pretreatment protects the mice from Con A-induced liver injury via inhibiting hepatocyte oxidative stress, inflammation and releasing of HMGB1.	Curcumin	27-35	high mobility group box 1	Mus musculus	173-178
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	RELA proto-oncogene, NF-kB subunit	Homo sapiens	112-115
22880132-0	2012	Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex.	Curcumin	0-8	ESCRT-II subunit protein VPS36	Saccharomyces cerevisiae S288C	70-75
22880132-7	2012	We show that curcumin prevents htt72Q-GFP aggregation by down regulating Vps36, a component of the ESCRT-II (Endosomal sorting complex required for transport).	Curcumin	13-21	ESCRT-II subunit protein VPS36	Saccharomyces cerevisiae S288C	73-78
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	mucin 1, cell surface associated	Homo sapiens	151-155
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	RELA proto-oncogene, NF-kB subunit	Homo sapiens	112-115
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	mucin 1, cell surface associated	Homo sapiens	151-155
22448259-7	2012	Moreover, we have observed that Sema 3A overexpressed melanoma clone showed increased sensitivity towards curcumin and Dacarbazine, anti-cancer agents.	Curcumin	106-114	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	32-39
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	mucin 1, cell surface associated	Homo sapiens	151-155
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	RELA proto-oncogene, NF-kB subunit	Homo sapiens	112-115
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	mucin 1, cell surface associated	Homo sapiens	151-155
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	RELA proto-oncogene, NF-kB subunit	Homo sapiens	112-115
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	mucin 1, cell surface associated	Homo sapiens	151-155
22470431-8	2012	We document that curcumin can inhibit the expression of MRP-1 and LRP gene/protein in a concentration dependent manner in Y79 cells.	Curcumin	17-25	major vault protein	Homo sapiens	66-69
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	mucin 1, cell surface associated	Homo sapiens	151-155
22363450-6	2012	Cell cycle analysis demonstrated that curcumin treatment induced cell death and down regulated cyclin D1 levels.	Curcumin	38-46	cyclin D1	Homo sapiens	95-104
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	RELA proto-oncogene, NF-kB subunit	Homo sapiens	112-115
22363450-8	2012	Furthermore, curcumin treatment led to reduced Notch-1 activation, expression of Jagged-1 and its downstream target Hes-1.	Curcumin	13-21	hes family bHLH transcription factor 1	Homo sapiens	116-121
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	mucin 1, cell surface associated	Homo sapiens	151-155
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	RELA proto-oncogene, NF-kB subunit	Homo sapiens	112-115
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	mucin 1, cell surface associated	Homo sapiens	151-155
21932293-4	2011	Curcumin prevented the increased NTPDase, 5"-nucleotidase and AChE activities caused by smoke exposure.	Curcumin	0-8	5' nucleotidase, ecto	Rattus norvegicus	42-57
25971429-10	2015	Moreover, while exogenous expression of MUC1-C had little effect on curcumin-reduced p65, the overexpression of p65 reversed the effect of curcumin on MUC1-C protein expression suggesting that p65 is upstream of MUC1-C. Intriguingly, we showed that exogenous expression of MUC1-C feedback diminished the effect of curcumin on phosphorylation of ERK1/2 and SAPK/JNK, and antagonized the effect of curcumin on cell growth.	Curcumin	139-147	mucin 1, cell surface associated	Homo sapiens	151-155
25971429-11	2015	CONCLUSION: Our results show that curcumin inhibits the growth of androgen-independent prostate cancer cells through ERK1/2- and SAPK/JNK-mediated inhibition of p65, followed by reducing expression of MUC1-C protein.	Curcumin	34-42	RELA proto-oncogene, NF-kB subunit	Homo sapiens	161-164
22101335-4	2011	Knockdown experiments and knockout cells excluded a role of caspase-8 in curcumin-induced caspase-3 activation.	Curcumin	73-81	caspase 8	Homo sapiens	60-69
25971429-11	2015	CONCLUSION: Our results show that curcumin inhibits the growth of androgen-independent prostate cancer cells through ERK1/2- and SAPK/JNK-mediated inhibition of p65, followed by reducing expression of MUC1-C protein.	Curcumin	34-42	mucin 1, cell surface associated	Homo sapiens	201-205
21344388-0	2011	HDAC1/NFkappaB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation.	Curcumin	38-46	tyrosine aminotransferase	Homo sapiens	61-64
25971429-13	2015	The negative feedback regulatory loop of MUC1-C to ERK1/2 and SAPK/JNK further demonstrates the role of MUC1-C that contributes to the overall responses of curcumin.	Curcumin	156-164	mucin 1, cell surface associated	Homo sapiens	41-45
21344388-3	2011	We investigated whether curcumin had the potential to inhibit Tat-induced long terminal repeat region (LTR) transactivation.	Curcumin	24-32	tyrosine aminotransferase	Homo sapiens	62-65
21344388-5	2011	Curcumin reversed Tat-induced down-regulation of HDAC1 expression in multinuclear activation of galactosidase indicator (MAGI) cells.	Curcumin	0-8	tyrosine aminotransferase	Homo sapiens	18-21
25971429-13	2015	The negative feedback regulatory loop of MUC1-C to ERK1/2 and SAPK/JNK further demonstrates the role of MUC1-C that contributes to the overall responses of curcumin.	Curcumin	156-164	mucin 1, cell surface associated	Homo sapiens	104-108
21344388-6	2011	Treatment with curcumin reversed Tat-induced dissociation of HDAC1 from LTR; and curcumin caused a decline in the binding of p65/NFkappaB to LTR promoters stimulated by Tat.	Curcumin	15-23	tyrosine aminotransferase	Homo sapiens	33-36
21344388-6	2011	Treatment with curcumin reversed Tat-induced dissociation of HDAC1 from LTR; and curcumin caused a decline in the binding of p65/NFkappaB to LTR promoters stimulated by Tat.	Curcumin	15-23	tyrosine aminotransferase	Homo sapiens	169-172
21344388-6	2011	Treatment with curcumin reversed Tat-induced dissociation of HDAC1 from LTR; and curcumin caused a decline in the binding of p65/NFkappaB to LTR promoters stimulated by Tat.	Curcumin	81-89	RELA proto-oncogene, NF-kB subunit	Homo sapiens	125-128
21344388-6	2011	Treatment with curcumin reversed Tat-induced dissociation of HDAC1 from LTR; and curcumin caused a decline in the binding of p65/NFkappaB to LTR promoters stimulated by Tat.	Curcumin	81-89	tyrosine aminotransferase	Homo sapiens	169-172
21344388-7	2011	Curcumin attenuated Tat-induced p65 phosphorylation and IKK phosphorylation.	Curcumin	0-8	tyrosine aminotransferase	Homo sapiens	20-23
21344388-7	2011	Curcumin attenuated Tat-induced p65 phosphorylation and IKK phosphorylation.	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	32-35
25938910-0	2015	Curcumin Prevents Palmitoylation of Integrin beta4 in Breast Cancer Cells.	Curcumin	0-8	integrin subunit beta 4	Homo sapiens	36-50
21344388-8	2011	Curcumin reversed Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase (ACC) activation.	Curcumin	0-8	tyrosine aminotransferase	Homo sapiens	18-21
25938910-2	2015	Our previous studies showed that curcumin inhibits integrin beta4 (ITG beta4)-dependent migration by blocking interaction of this integrin with growth factor receptors in lipid rafts.	Curcumin	33-41	integrin subunit beta 4	Homo sapiens	51-65
21344388-8	2011	Curcumin reversed Tat-mediated reduction in AMPK activation and downstream acetyl-CoA carboxylase (ACC) activation.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	44-48
25938910-2	2015	Our previous studies showed that curcumin inhibits integrin beta4 (ITG beta4)-dependent migration by blocking interaction of this integrin with growth factor receptors in lipid rafts.	Curcumin	33-41	integrin subunit beta 4	Homo sapiens	67-76
21344388-9	2011	Collectively, our data provide new insights into understanding of the molecular mechanisms of curcumin inhibited Tat-regulated transcription, suggesting that targeting AMPK/HDAC1/NFkappaB pathway could serve as new anti-HIV-1 agents.	Curcumin	94-102	tyrosine aminotransferase	Homo sapiens	113-116
21344388-9	2011	Collectively, our data provide new insights into understanding of the molecular mechanisms of curcumin inhibited Tat-regulated transcription, suggesting that targeting AMPK/HDAC1/NFkappaB pathway could serve as new anti-HIV-1 agents.	Curcumin	94-102	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	168-172
25938910-3	2015	In the current study, we investigated the possibility that curcumin inhibits ITG beta4 palmitoylation, a post-translational modification required for its lipid raft localization and signaling activity.	Curcumin	59-67	integrin subunit beta 4	Homo sapiens	77-86
25938910-4	2015	We found that the levels of ITG beta4 palmitoylation correlated with the invasive potential of breast cancer cells, and that curcumin effectively reduced the levels of ITG beta4 palmitoylation in invasive breast cancer cells.	Curcumin	125-133	integrin subunit beta 4	Homo sapiens	168-177
21695461-0	2011	Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression.	Curcumin	0-8	intercellular adhesion molecule 1	Mus musculus	91-124
21695461-0	2011	Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression.	Curcumin	0-8	intercellular adhesion molecule 1	Mus musculus	126-132
25938910-5	2015	Through studies of ITG beta4 palmitoylation kinetics, we concluded curcumin suppressed palmitoylation independent of growth factor-induced phosphorylation of key ITG beta4 Ser and Tyr residues.	Curcumin	67-75	integrin subunit beta 4	Homo sapiens	19-28
21695461-0	2011	Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression.	Curcumin	0-8	chemokine (C-X-C motif) ligand 10	Mus musculus	138-144
25938910-6	2015	Rather, curcumin blocked autoacylation of the palmitoyl acyltransferase DHHC3 that is responsible for ITG beta4 palmitoylation.	Curcumin	8-16	integrin subunit beta 4	Homo sapiens	102-111
21695461-7	2011	Furthermore, the expression levels of intercellular adhesion molecule-1 (ICAM-1) and the interferon-inducible chemokine CXCL10 in hepatic tissue were significantly decreased by curcumin pretreatment.	Curcumin	177-185	intercellular adhesion molecule 1	Mus musculus	38-71
25938910-8	2015	Our studies reveal a novel paradigm for curcumin to account for much of its biological activity, and specifically, how it is able to suppress the signaling function of ITG beta4 in breast cancer cells.	Curcumin	40-48	integrin subunit beta 4	Homo sapiens	168-177
21695461-7	2011	Furthermore, the expression levels of intercellular adhesion molecule-1 (ICAM-1) and the interferon-inducible chemokine CXCL10 in hepatic tissue were significantly decreased by curcumin pretreatment.	Curcumin	177-185	intercellular adhesion molecule 1	Mus musculus	73-79
21695461-7	2011	Furthermore, the expression levels of intercellular adhesion molecule-1 (ICAM-1) and the interferon-inducible chemokine CXCL10 in hepatic tissue were significantly decreased by curcumin pretreatment.	Curcumin	177-185	chemokine (C-X-C motif) ligand 10	Mus musculus	120-126
25891083-9	2015	However, pretreatment with curcumin (2.5-20 mumol/L) dose-dependently attenuated all above-mentioned pathological changes in appoptosin-transfected SH-SY5Y cells.	Curcumin	27-35	solute carrier family 25 member 38	Homo sapiens	125-135
22126332-14	2011	CONCLUSION: This study demonstrates that curcumin increases the expression of cathepsins K and L in lung which an effect on lung fibroblast cell behavior such as proliferation, migration and apoptosis rates and on the expression of TGF-beta1 in mouse lung and HFL-1 cells.	Curcumin	41-49	transforming growth factor, beta 1	Mus musculus	232-241
25891083-12	2015	However, pretreatment with curcumin (2.5-20 mumol/L) dose-dependently attenuated all above-mentioned pathological changes in appoptosin-transfected SH-SY5Y cells.	Curcumin	27-35	solute carrier family 25 member 38	Homo sapiens	125-135
22113199-0	2011	Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress.	Curcumin	69-77	peroxiredoxin 6	Homo sapiens	58-63
25891083-13	2015	CONCLUSION: Curcumin inhibits appoptosin-induced apoptosis in SH-SY5Y cells by upregulating the expression of HO-1, reducing the production of intracellular heme and ROS, and preventing the DeltaPsim loss.	Curcumin	12-20	solute carrier family 25 member 38	Homo sapiens	30-40
22113199-3	2011	Using human lens epithelial cells (hLECs) and Prdx6-deficient cells, we show the evidence that curcumin protects cells by upregulating Prdx6 transcription via invoking specificity protein 1 (Sp1) activity against proapoptotic stimuli.	Curcumin	95-103	peroxiredoxin 6	Homo sapiens	46-51
26191140-0	2015	Inhibition of tobacco smoke-induced bladder MAPK activation and epithelial-mesenchymal transition in mice by curcumin.	Curcumin	109-117	mitogen-activated protein kinase homolog MMK2	Nicotiana tabacum	44-48
22113199-3	2011	Using human lens epithelial cells (hLECs) and Prdx6-deficient cells, we show the evidence that curcumin protects cells by upregulating Prdx6 transcription via invoking specificity protein 1 (Sp1) activity against proapoptotic stimuli.	Curcumin	95-103	peroxiredoxin 6	Homo sapiens	135-140
22113199-4	2011	Curcumin enhanced Sp1 and Prdx6 mRNA and protein expression in a concentration-dependent manner, as evidenced by western and real-time PCR analyses, and thereby negatively regulated ROS-mediated apoptosis by blunting ROS expression and lipid peroxidation.	Curcumin	0-8	peroxiredoxin 6	Homo sapiens	26-31
22113199-7	2011	Curcumin treatment of LECs enhanced Sp1 binding to its sites, consistent with curcumin-dependent stimulation of Prdx6 promoter with Sp1 sites and cytoprotection.	Curcumin	0-8	peroxiredoxin 6	Homo sapiens	112-117
22113199-7	2011	Curcumin treatment of LECs enhanced Sp1 binding to its sites, consistent with curcumin-dependent stimulation of Prdx6 promoter with Sp1 sites and cytoprotection.	Curcumin	78-86	peroxiredoxin 6	Homo sapiens	112-117
26191140-8	2015	Curcumin treatment effectively attenuated TS-triggered activation of ERK1/2, JNK and p38 MAPK pathways, AP-1 proteins and EMT alterations in bladder tissue.	Curcumin	0-8	mitogen-activated protein kinase 3	Mus musculus	69-75
26191140-8	2015	Curcumin treatment effectively attenuated TS-triggered activation of ERK1/2, JNK and p38 MAPK pathways, AP-1 proteins and EMT alterations in bladder tissue.	Curcumin	0-8	mitogen-activated protein kinase 14	Mus musculus	85-88
26191140-8	2015	Curcumin treatment effectively attenuated TS-triggered activation of ERK1/2, JNK and p38 MAPK pathways, AP-1 proteins and EMT alterations in bladder tissue.	Curcumin	0-8	mitogen-activated protein kinase homolog MMK2	Nicotiana tabacum	89-93
26191140-9	2015	These results suggest the protective effects of curcumin in TS-induced MAPK activation and EMT, thus providing new insights into the chemoprevention of TS-associated bladder cancer.	Curcumin	48-56	mitogen-activated protein kinase homolog MMK2	Nicotiana tabacum	71-75
21757545-0	2011	Curcumin-induced mitotic spindle defect and cell cycle arrest in human bladder cancer cells occurs partly through inhibition of aurora A.	Curcumin	0-8	aurora kinase A	Homo sapiens	128-136
26018265-4	2015	Curcumin treatment significantly reduced H3K9 acetylation level at Egr-1 binding site and decreased both the binding of Egr-1 to promoter region II and gdnf mRNA levels in C6 astroglioma cells (P&lt;0.05).	Curcumin	0-8	glial cell derived neurotrophic factor	Rattus norvegicus	152-156
21757545-3	2011	However, the effect of curcumin on Aurora A has not been reported.	Curcumin	23-31	aurora kinase A	Homo sapiens	35-43
21757545-4	2011	In this study, Aurora A promoter activity and mRNA expression were inhibited in curcumin-treated human bladder cancer T24 cells, suggesting that Aurora A is regulated at the transcription level.	Curcumin	80-88	aurora kinase A	Homo sapiens	15-23
21757545-4	2011	In this study, Aurora A promoter activity and mRNA expression were inhibited in curcumin-treated human bladder cancer T24 cells, suggesting that Aurora A is regulated at the transcription level.	Curcumin	80-88	aurora kinase A	Homo sapiens	145-153
25910231-3	2015	In the current manuscript, we investigated the mechanism of curcumin-induced apoptosis in upper aerodigestive tract cancer cell lines and showed that curcumin-induced apoptosis is mediated by the modulation of multiple pathways such as induction of p73, and inhibition of p-AKT and Bcl-2.	Curcumin	60-68	tumor protein p73	Homo sapiens	249-252
21757545-5	2011	We also found that curcumin preferentially inhibited the growth of T24 cells, which show a higher proliferation rate, invasion activity, and expression level of Aurora A compared with that of human immortalized uroepithelial E7cells.	Curcumin	19-27	aurora kinase A	Homo sapiens	161-169
21757545-6	2011	Furthermore, inhibition of phosphorylation of Aurora A and its downstream target histone H3 accompanied by the formation of monopolar spindle, induction of G(2)/M phase arrest, and reduction in cell division in response to curcumin were detected in T24 cells.	Curcumin	223-231	aurora kinase A	Homo sapiens	46-54
21757545-7	2011	These curcumin-induced phenomena were similar to those using Aurora A small interfering RNA and were attenuated by ectopic expression of Aurora A.	Curcumin	6-14	aurora kinase A	Homo sapiens	61-69
25966111-0	2015	Effect of curcumin on p38MAPK expression in DSS-induced murine ulcerative colitis.	Curcumin	10-18	mitogen-activated protein kinase 14	Mus musculus	22-29
21757545-7	2011	These curcumin-induced phenomena were similar to those using Aurora A small interfering RNA and were attenuated by ectopic expression of Aurora A.	Curcumin	6-14	aurora kinase A	Homo sapiens	137-145
21757545-8	2011	Therefore, the antitumor mechanism of curcumin is Aurora A-related, which further supports the application of curcumin in treatments of human cancers.	Curcumin	38-46	aurora kinase A	Homo sapiens	50-58
21757545-8	2011	Therefore, the antitumor mechanism of curcumin is Aurora A-related, which further supports the application of curcumin in treatments of human cancers.	Curcumin	110-118	aurora kinase A	Homo sapiens	50-58
21616659-8	2011	MMC and curcumin together synergistically enhanced apoptosis in MCF-7 cells and the apoptosis most likely resulted from both the activation of caspases and modulation of bcl-2/bax expression.	Curcumin	8-16	caspase 8	Homo sapiens	143-151
21633290-0	2011	Curcumin and resveratrol synergistically stimulate p21 and regulate cox-2 by maintaining adequate zinc levels during lung carcinogenesis.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	68-73
25966111-7	2015	Curcumin had a therapeutic effect, which probably played a role in UC treatment by inhibiting the p38MAPK signaling pathway, thereby reducing the release of TNF-alpha.	Curcumin	0-8	mitogen-activated protein kinase 14	Mus musculus	98-105
21633290-1	2011	This study explored the efficacy of curcumin and resveratrol in maintaining adequate zinc levels to regulate p21 and cyclooxygenase-2 (cox-2) during benzo[a]pyrene (BP)-induced lung carcinogenesis.	Curcumin	36-44	prostaglandin-endoperoxide synthase 2	Mus musculus	117-133
25860911-7	2015	In addition, curcumin modulated inflammation via upregulation of TGF-beta and reciprocal regulation of iNOS and COX2.	Curcumin	13-21	cytochrome c oxidase II, mitochondrial	Mus musculus	112-116
21633290-1	2011	This study explored the efficacy of curcumin and resveratrol in maintaining adequate zinc levels to regulate p21 and cyclooxygenase-2 (cox-2) during benzo[a]pyrene (BP)-induced lung carcinogenesis.	Curcumin	36-44	prostaglandin-endoperoxide synthase 2	Mus musculus	135-140
21633290-7	2011	This study, therefore, concludes that combined treatment with curcumin and resveratrol maintains adequate zinc levels and regulates inflammation by cox-2 and cell cycle arrest by p21 during lung carcinogenesis in mice.	Curcumin	62-70	prostaglandin-endoperoxide synthase 2	Mus musculus	148-153
22396328-0	2012	Curcumin protects against regional myocardial ischemia/reperfusion injury through activation of RISK/GSK-3beta and inhibition of p38 MAPK and JNK.	Curcumin	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	101-110
25860911-8	2015	The study suggests that during long term effect, curcumin leads to prevention of cancer by inducing phase-II antioxidant enzymes via activation of Nrf2 signalling, restoration of tumour suppressor p53 and modulation of inflammatory mediators like iNOS and COX2 in liver of lymphoma bearing mice.	Curcumin	49-57	cytochrome c oxidase II, mitochondrial	Mus musculus	256-260
22396328-0	2012	Curcumin protects against regional myocardial ischemia/reperfusion injury through activation of RISK/GSK-3beta and inhibition of p38 MAPK and JNK.	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	133-137
22396328-8	2012	Curcumin significantly enhanced the phosphorylation of Akt, ERK1/2, and GSK-3beta, while it reduced that of p38 and JNK.	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	60-66
25712644-9	2015	Various dosage of Curcumin attenuated these effects by significantly lowering lipid peroxidation, GSSG level, Bax concentration, caspase-3 and caspase-9 activities, while increasing superoxide dismutase and glutathione peroxidase activity, GSH level and Bcl-2 concentration.	Curcumin	18-26	caspase 3	Rattus norvegicus	129-138
22396328-8	2012	Curcumin significantly enhanced the phosphorylation of Akt, ERK1/2, and GSK-3beta, while it reduced that of p38 and JNK.	Curcumin	0-8	glycogen synthase kinase 3 beta	Rattus norvegicus	72-81
22396328-9	2012	Wortmannin or U0126 abolished enhanced phosphorylation of GSK-3beta induced by curcumin.	Curcumin	79-87	glycogen synthase kinase 3 beta	Rattus norvegicus	58-67
22396328-10	2012	SB216763 alone or combined with curcumin reduced the infarct size and enhanced phosphorylation of GSK-3beta compared with the control.	Curcumin	32-40	glycogen synthase kinase 3 beta	Rattus norvegicus	98-107
22396328-11	2012	CONCLUSIONS: Preconditioning by curcumin effectively protects against regional myocardial I/R injury through the activation of prosurvival kinases involving PI3K-Akt, ERK1/2, and GSK-3beta, and attenuation of p38 and JNK.	Curcumin	32-40	mitogen activated protein kinase 3	Rattus norvegicus	167-173
22396328-11	2012	CONCLUSIONS: Preconditioning by curcumin effectively protects against regional myocardial I/R injury through the activation of prosurvival kinases involving PI3K-Akt, ERK1/2, and GSK-3beta, and attenuation of p38 and JNK.	Curcumin	32-40	glycogen synthase kinase 3 beta	Rattus norvegicus	179-188
22402368-6	2012	The EAE mice also showed elevated expression of IL-12 and IL-23 that decreased after treatment with curcumin.	Curcumin	100-108	interleukin 23, alpha subunit p19	Mus musculus	58-63
21699455-7	2011	Curcumin-ND decreased cyclin D1, pAkt, pIkappaBalpha, and Bcl(2) protein.	Curcumin	0-8	cyclin D1	Homo sapiens	22-31
25542083-4	2015	Autophagy preceded apoptosis, and blocking this response with autophagy inhibitors (3-methyl-adenine, ATG7 siRNA and chloroquine) rendered cells susceptible to temozolomide and curcumin alone or combinations by increasing apoptosis.	Curcumin	177-185	autophagy related 7	Homo sapiens	102-106
22402368-7	2012	Ex vivo and in vitro treatment with curcumin resulted in a dose-dependent decrease in the secretion of IFNgamma, IL-17, IL-12 and IL-23 in culture.	Curcumin	36-44	interleukin 23, alpha subunit p19	Mus musculus	130-135
22402368-8	2012	The inhibition of EAE by curcumin was also associated with an up-regulation of IL-10, peroxisome proliferator activated receptor gamma and CD4(+)CD25(+-)Foxp3(+) Treg cells in the CNS and lymphoid organs.	Curcumin	25-33	peroxisome proliferator activated receptor gamma	Mus musculus	86-134
25497868-6	2015	Significant inhibition of VEGF, angiopoietin 1, angiopoietin 2, platelet derived growth factor, COX-2, and TGFbeta secretion was observed in PC cell lines treated with UBS109, EF31 or curcumin.	Curcumin	184-192	angiopoietin 2	Homo sapiens	48-62
25730045-11	2015	In conclusion, curcumin has antiproliferative and proapoptotic activities on A375 cells, the mechanism of which may be related to the inhibition of JAK-2/STAT-3 signaling pathway.	Curcumin	15-23	Janus kinase 2	Homo sapiens	148-153
22564708-4	2012	We evaluated whether curcumin treatment is associated with the modulation of PKC-alpha and -beta2-mitogen-activated protein kinase (MAPK) pathway in experimental diabetic cardiomyopathy.	Curcumin	21-29	mitogen activated protein kinase 3	Rattus norvegicus	132-136
22564708-7	2012	We demonstrate that curcumin significantly prevented diabetes-induced translocation of PKC-alpha and -beta2 to membranous fraction and diabetes-induced increased phosphorylation of p38MAPK and extracellular regulated-signal kinase (ERK)1/2 in left ventricular tissues of diabetic rats.	Curcumin	20-28	mitogen activated protein kinase 3	Rattus norvegicus	193-239
22564708-8	2012	Curcumin treatment also markedly decreased NAD(P)H oxidase subunits (p67phox, p22phox, gp91phox), growth factors (transforming growth factor-beta, osteopontin) and myocyte enhancer factor-2 protein expression as well as inhibited NF-kappaB activity at nuclear level.	Curcumin	0-8	secreted phosphoprotein 1	Rattus norvegicus	147-158
21218454-0	2011	Curcumin prevents haloperidol-induced development of abnormal oro-facial movements: possible implications of Bcl-XL in its mechanism of action.	Curcumin	0-8	Bcl2-like 1	Rattus norvegicus	109-115
21218454-8	2011	A number of proteins were altered by curcumin, among them an antiapoptotic protein, Bcl-XL, was significantly upregulated.	Curcumin	37-45	Bcl2-like 1	Rattus norvegicus	84-90
22564708-11	2012	Taken together, it is suggested that curcumin by inhibiting PKC-alpha and -beta2-MAPK pathway may be useful as an adjuvant therapy for the prevention of diabetic cardiomyopathy.	Curcumin	37-45	mitogen activated protein kinase 3	Rattus norvegicus	81-85
25543853-1	2015	Curcumin (CUR) is a phytochemical that inhibits the xenobiotic ABC efflux transporters implicated in cancer multidrug resistance (MDR), such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 and 5 (MRP1 and MRP5).	Curcumin	0-8	ATP binding cassette subfamily C member 5	Homo sapiens	270-274
21314641-7	2011	Moreover, pretreatment of cells with curcumin, an activation of AP-1 (activator protein-1) inhibitor, inhibited silica-induced cell cycle alteration, the decreased expression of E2F-4 and overexpression of cyclin D1 and CDK4.	Curcumin	37-45	E2F transcription factor 4	Homo sapiens	178-183
25444916-0	2015	Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer.	Curcumin	0-8	MLX interacting protein	Homo sapiens	50-53
21314641-7	2011	Moreover, pretreatment of cells with curcumin, an activation of AP-1 (activator protein-1) inhibitor, inhibited silica-induced cell cycle alteration, the decreased expression of E2F-4 and overexpression of cyclin D1 and CDK4.	Curcumin	37-45	cyclin D1	Homo sapiens	206-215
21314641-7	2011	Moreover, pretreatment of cells with curcumin, an activation of AP-1 (activator protein-1) inhibitor, inhibited silica-induced cell cycle alteration, the decreased expression of E2F-4 and overexpression of cyclin D1 and CDK4.	Curcumin	37-45	cyclin dependent kinase 4	Homo sapiens	220-224
22954786-8	2012	Knocking down both p300/CBP by RNAi or by chemical inhibition with curcumin greatly reduced XPG acetylation, and a concomitant accumulation of the protein at DNA damage sites was observed.	Curcumin	67-75	E1A binding protein p300	Homo sapiens	19-23
25444916-5	2015	miRNA microarray and qPCR indicated that miR-192-5p and miR-215 were the most responsive miRNAs upon curcumin treatment in H460 and A427 cells.	Curcumin	101-109	MLX interacting protein	Homo sapiens	0-3
25474544-5	2015	Curcumin increased the expression of glucose transporter 2 (GLUT2) and phosphorylation of insulin receptor (IR), insulin receptor substrate-1 (IRS1), phosphatidylinositol-3-kinase (PI3K) and AKT in the INS-1 cells.	Curcumin	0-8	insulin receptor	Rattus norvegicus	90-106
22840386-8	2012	Furthermore, the expression levels of caspase-3 and the Bax/Bcl-2 ratio were significantly decreased in the aortic walls of curcumin-treated rats.	Curcumin	124-132	caspase 3	Rattus norvegicus	38-47
25474544-5	2015	Curcumin increased the expression of glucose transporter 2 (GLUT2) and phosphorylation of insulin receptor (IR), insulin receptor substrate-1 (IRS1), phosphatidylinositol-3-kinase (PI3K) and AKT in the INS-1 cells.	Curcumin	0-8	insulin receptor	Rattus norvegicus	108-110
22692588-5	2012	We demonstrate that curcumin effectively suppressed HFFA-induced production of phosphoenol pyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) in hepatocytes.	Curcumin	20-28	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	126-147
22977552-0	2011	Turmeric and curcumin suppress presenilin 1 protein expression in Jurkat cells.	Curcumin	13-21	presenilin 1	Homo sapiens	31-43
22977552-3	2011	Our results showed that curcumin, a component of turmeric, induced the down-regulation of presenilin 1 protein in Jurkat and K562 cell lines.	Curcumin	24-32	presenilin 1	Homo sapiens	90-102
22692588-5	2012	We demonstrate that curcumin effectively suppressed HFFA-induced production of phosphoenol pyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) in hepatocytes.	Curcumin	20-28	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	149-155
22692588-6	2012	Not only did curcumin treatment increase mitochondrial DNA (mtDNA) copy number in hepatocytes, but it also increased levels of transcriptional factors that regulate mitochondrial biogenesis, including peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC1alpha), nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (Tfam).	Curcumin	13-21	nuclear respiratory factor 1	Homo sapiens	282-310
22692588-6	2012	Not only did curcumin treatment increase mitochondrial DNA (mtDNA) copy number in hepatocytes, but it also increased levels of transcriptional factors that regulate mitochondrial biogenesis, including peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC1alpha), nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (Tfam).	Curcumin	13-21	nuclear respiratory factor 1	Homo sapiens	312-316
25474544-6	2015	Moreover, curcumin stimulation increased the expression of PDX-1 and GCK.	Curcumin	10-18	glucokinase	Rattus norvegicus	69-72
22507634-4	2012	We found that neutrophil elastase, an important regulator of inflammatory processes, directly triggered tumor cell proliferation in human lung adenocarcinoma A549 cells, and curcumin could completely suppress the excess tumor proliferation induced by neutrophil elastase.	Curcumin	174-182	elastase, neutrophil expressed	Homo sapiens	251-270
25580684-2	2015	Our novel curcumin analogue BAT3 was identified to be the most potent NF-kappaB inhibitor and EMSA assays clearly showed inhibition of NF-kappaB/DNA-binding in the presence of BAT3, in agreement with reporter gene results.	Curcumin	10-18	BAG cochaperone 6	Homo sapiens	28-32
22579915-0	2012	beta2-adrenoceptor and insulin receptor expression in the skeletal muscle of streptozotocin induced diabetic rats: antagonism by vitamin D3 and curcumin.	Curcumin	144-152	insulin receptor	Rattus norvegicus	23-39
25580684-2	2015	Our novel curcumin analogue BAT3 was identified to be the most potent NF-kappaB inhibitor and EMSA assays clearly showed inhibition of NF-kappaB/DNA-binding in the presence of BAT3, in agreement with reporter gene results.	Curcumin	10-18	BAG cochaperone 6	Homo sapiens	176-180
21466813-4	2011	This study aimed at examining effects of resveratrol alone and in combination with curcumin or chrysin on UGT induction in Caco-2 cells.	Curcumin	83-91	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	106-109
25229889-0	2015	Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro.	Curcumin	0-8	hexokinase 2	Homo sapiens	90-103
20815812-6	2011	Curcumin treatment reduced miR-21 promoter activity and expression in a dose-dependent manner by inhibiting AP-1 binding to the promoter, and induced the expression of the tumour suppressor Pdcd4 (programmed cell death protein 4), which is a target of miR-21.	Curcumin	0-8	programmed cell death 4	Homo sapiens	190-195
20815812-6	2011	Curcumin treatment reduced miR-21 promoter activity and expression in a dose-dependent manner by inhibiting AP-1 binding to the promoter, and induced the expression of the tumour suppressor Pdcd4 (programmed cell death protein 4), which is a target of miR-21.	Curcumin	0-8	programmed cell death 4	Homo sapiens	197-228
20815812-10	2011	Taken together, this is the first paper to show that curcumin inhibits the transcriptional regulation of miR-21 via AP-1, suppresses cell proliferation, tumour growth, invasion and in vivo metastasis, and stabilizes the expression of the tumour suppressor Pdcd4 in colorectal cancer.	Curcumin	53-61	programmed cell death 4	Homo sapiens	256-261
21729550-8	2011	The expression of NF-kappaB P65 in nucleus was downregulated in either the curcumin or bortezomib group, however, distribution of NF-kappaB P65 in cytoplasm was observed in combined group.	Curcumin	75-83	RELA proto-oncogene, NF-kB subunit	Homo sapiens	18-31
22446486-6	2012	Conversely, prevention of histone acetylation by the histone acetyltransferase inhibitor curcumin diminished PU.1 expression after IL-9-inducing stimulation.	Curcumin	89-97	interleukin 9	Homo sapiens	131-135
22622204-6	2012	Curcumin can also reverse FOXO1 (a mediator of autophagy) nuclear localization along with causing an elevated level of cytoplasmic acetylation of FOXO1 and the interaction of acetylated FOXO1 and ATG7, under the circumstance of oxidative stress.	Curcumin	0-8	autophagy related 7	Homo sapiens	196-200
22622204-7	2012	Additionally, knockdown of FOXO1 by shRNA inhibits not only the protective effects that curcumin induced, but the autophagic process, from the quantity of LC3-II to the expression of RAB7.	Curcumin	88-96	RAB7B, member RAS oncogene family	Homo sapiens	183-187
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	19-27	glutathione reductase	Mus musculus	231-233
25229889-3	2015	On the one hand, curcumin downregulated the expression and activity of hexokinase II (HKII) in HCT116 and HT29 cells in a concentration-dependent manner, but had little effect on the other key glycolytic enzymes (PFK, PGM, and LDH).	Curcumin	17-25	hexokinase 2	Homo sapiens	71-84
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	32-40	glutathione reductase	Mus musculus	231-233
25229889-3	2015	On the one hand, curcumin downregulated the expression and activity of hexokinase II (HKII) in HCT116 and HT29 cells in a concentration-dependent manner, but had little effect on the other key glycolytic enzymes (PFK, PGM, and LDH).	Curcumin	17-25	hexokinase 2	Homo sapiens	86-90
25229889-4	2015	On the other, curcumin induced dissociation of HKII from the mitochondria, resulting in mitochondrial-mediated apoptosis.	Curcumin	14-22	hexokinase 2	Homo sapiens	47-51
25229889-5	2015	Furthermore, the phosphorylation of mitochondrial HKII through AKT was responsible for the curcumin-induced dissociation of HKII, which was different from the mechanism of HKII inhibitor 3-BrPA.	Curcumin	91-99	hexokinase 2	Homo sapiens	50-54
25229889-5	2015	Furthermore, the phosphorylation of mitochondrial HKII through AKT was responsible for the curcumin-induced dissociation of HKII, which was different from the mechanism of HKII inhibitor 3-BrPA.	Curcumin	91-99	hexokinase 2	Homo sapiens	124-128
25229889-5	2015	Furthermore, the phosphorylation of mitochondrial HKII through AKT was responsible for the curcumin-induced dissociation of HKII, which was different from the mechanism of HKII inhibitor 3-BrPA.	Curcumin	91-99	hexokinase 2	Homo sapiens	124-128
25229889-6	2015	These results have important implications for the metabolism reprogramming effect and the susceptibility to curcumin-induced mitochondrial cytotoxicity through the regulation of HKII, and provide a molecular basis for the development of naturally compounds as novel anticancer agents for colorectal carcinoma.	Curcumin	108-116	hexokinase 2	Homo sapiens	178-182
22266952-0	2012	Expression analysis of Cdc42 in lung cancer and modulation of its expression             by curcumin in lung cancer cell lines.	Curcumin	92-100	cell division cycle 42	Homo sapiens	23-28
22266952-6	2012	In parallel,             801D cells were treated with curcumin and the effect on the expression of the             Cdc42 gene at the transcriptional and translational levels was analyzed by RT-PCR             and Western blotting.	Curcumin	54-62	cell division cycle 42	Homo sapiens	115-120
22266952-7	2012	Curcumin inhibited cell migration, invasion and downregulated             Cdc42 gene and Cdc42-related target gene expression in 801D cells.	Curcumin	0-8	cell division cycle 42	Homo sapiens	74-79
22266952-7	2012	Curcumin inhibited cell migration, invasion and downregulated             Cdc42 gene and Cdc42-related target gene expression in 801D cells.	Curcumin	0-8	cell division cycle 42	Homo sapiens	89-94
22266952-10	2012	Furthermore, xenograft experiments confirmed the suppression of tumor             growth and invasion in vivo, which was due to the effect of curcumin and the inhibition             of Cdc42 by curcumin.	Curcumin	194-202	cell division cycle 42	Homo sapiens	185-190
25446996-5	2015	To protect cells from STZ-induced stress-mediated damage, curcumin acted on the key mediators of the apoptotic cell death such as JNK and p38.	Curcumin	58-66	mitogen activated protein kinase 14	Rattus norvegicus	138-141
22266952-11	2012	Our results showing the downregulation of Cdc42 expression             by curcumin in lung cancer cells taken together with the clinical data suggest             a potential therapeutic role for curcumin in inducing Cdc42-mediated inhibition             of invasion of lung cancer cells.	Curcumin	74-82	cell division cycle 42	Homo sapiens	42-47
22266952-11	2012	Our results showing the downregulation of Cdc42 expression             by curcumin in lung cancer cells taken together with the clinical data suggest             a potential therapeutic role for curcumin in inducing Cdc42-mediated inhibition             of invasion of lung cancer cells.	Curcumin	74-82	cell division cycle 42	Homo sapiens	216-221
22266952-11	2012	Our results showing the downregulation of Cdc42 expression             by curcumin in lung cancer cells taken together with the clinical data suggest             a potential therapeutic role for curcumin in inducing Cdc42-mediated inhibition             of invasion of lung cancer cells.	Curcumin	195-203	cell division cycle 42	Homo sapiens	42-47
22266952-11	2012	Our results showing the downregulation of Cdc42 expression             by curcumin in lung cancer cells taken together with the clinical data suggest             a potential therapeutic role for curcumin in inducing Cdc42-mediated inhibition             of invasion of lung cancer cells.	Curcumin	195-203	cell division cycle 42	Homo sapiens	216-221
25792385-0	2015	Curcumin enhances the radiosensitivity of U87 cells by inducing DUSP-2 up-regulation.	Curcumin	0-8	dual specificity phosphatase 2	Homo sapiens	64-70
25792385-6	2015	Western blotting was applied to determine the effects of curcumin on protein expression of dual-specificity phosphatase-2 (DUSP-2), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) as well as phosphorylated ERK and JNK.	Curcumin	57-65	dual specificity phosphatase 2	Homo sapiens	91-121
25792385-6	2015	Western blotting was applied to determine the effects of curcumin on protein expression of dual-specificity phosphatase-2 (DUSP-2), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) as well as phosphorylated ERK and JNK.	Curcumin	57-65	dual specificity phosphatase 2	Homo sapiens	123-129
25792385-11	2015	Furthermore, we observed that curcumin increased DUSP-2 protein expression and decreased the phosphorylation of ERK and JNK.	Curcumin	30-38	dual specificity phosphatase 2	Homo sapiens	49-55
22414757-2	2012	Natural product curcumin is known to interact with PKC isoforms through the C1 domain and modulate PKC activity.	Curcumin	16-24	protein kinase C delta	Homo sapiens	51-54
25792385-12	2015	CONCLUSION: Our results suggest that low-dose curcumin may enhance the radiosensitivity of human glioma U87 cells in vitro by inducing G2/M cell cycle arrest through up-regulation of DUSP-2 expression and inhibition of ERK and JNK phosphorylation.	Curcumin	46-54	dual specificity phosphatase 2	Homo sapiens	183-189
22414757-2	2012	Natural product curcumin is known to interact with PKC isoforms through the C1 domain and modulate PKC activity.	Curcumin	16-24	protein kinase C delta	Homo sapiens	99-102
25723052-5	2014	Interestingly, treating db/db mice with curcumin improved or restored these parameters to normal levels; also curcumin increased liver mitochondrial ATPase activity in db/db mice relative to untreated db/db mice.	Curcumin	110-118	dynein, axonemal, heavy chain 8	Mus musculus	149-155
22414757-4	2012	To understand the importance of the two halves of curcumin in PKC binding and to develop effective PKC regulators, we synthesized a series of alkyl cinnamates (1-8), characterized absorption and fluorescence properties and measured binding affinities with the C1b subdomains of PKC isoforms.	Curcumin	50-58	protein kinase C delta	Homo sapiens	62-65
23162743-9	2012	Reductions in PAK1 by the anti-amyloid compound curcumin suppress synaptotoxicity.	Curcumin	48-56	p21 (RAC1) activated kinase 1	Homo sapiens	14-18
25033705-7	2014	RESULTS: Western-blotting: after the third generation of cells had been treated for 72 h, we observed that wnt3a and beta-catenin expression was significantly increased in the group receiving 500 nmol/L curcumin but not in the other groups.	Curcumin	203-211	Wnt family member 3A	Rattus norvegicus	107-112
22696871-4	2012	Curcumin has been reported as having a neural protective effect on the AD model, and could modulate the proliferation of tumor cells through the regulation of cyclin D1 and c-myc cell signaling pathways.	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	173-178
22696871-8	2012	RESULTS: The results showed that administration of curcumin (1-10 microM) could inhibit Abeta25-35 (40 microg/ml) induced primary cultured rat cortical neuron death, down-regulating activated caspase-3 protein expression.	Curcumin	51-59	caspase 3	Rattus norvegicus	192-201
25774181-2	2012	Graded concentration and time course experiments demonstrate that curcumin significantly upregulates phosphatidylinositol 3-kinase (PI3K), Akt, nuclear factor E2-related factor-2 (Nrf2), heme oxygenase 1 and ferritin expression, and that it significantly downregulates heme oxygenase 2, reactive oxygen species and amyloid-beta 40/42 expression.	Curcumin	66-74	heme oxygenase 2	Homo sapiens	269-285
25432491-12	2014	Curcumin administration decreased MMP-8 expression in liver of paracetamol administered rats.	Curcumin	0-8	matrix metallopeptidase 8	Rattus norvegicus	34-39
21942294-0	2012	Curcumin heals indomethacin-induced gastric ulceration by stimulation of angiogenesis and restitution of collagen fibers via VEGF and MMP-2 mediated signaling.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	134-139
21942294-4	2012	Interestingly, curcumin blocked ulceration by induction of collagenization and angiogenesis in gastric tissues via upregulation of MMP-2, membrane type (MT) 1-MMP, VEGF, and transforming growth factor (TGF)-beta at protein and messenger ribonucleic acid (mRNA) levels.	Curcumin	15-23	matrix metallopeptidase 2	Homo sapiens	131-136
21942294-4	2012	Interestingly, curcumin blocked ulceration by induction of collagenization and angiogenesis in gastric tissues via upregulation of MMP-2, membrane type (MT) 1-MMP, VEGF, and transforming growth factor (TGF)-beta at protein and messenger ribonucleic acid (mRNA) levels.	Curcumin	15-23	matrix metallopeptidase 14	Homo sapiens	138-162
21942294-6	2012	During healing, curcumin promoted collagenization and angiogenesis as well as enhanced MMP-2 activity via positive MT1-MMP regulation and negative tissue inhibitor of metalloproteinase-2 regulation.	Curcumin	16-24	matrix metallopeptidase 2	Homo sapiens	87-92
21942294-6	2012	During healing, curcumin promoted collagenization and angiogenesis as well as enhanced MMP-2 activity via positive MT1-MMP regulation and negative tissue inhibitor of metalloproteinase-2 regulation.	Curcumin	16-24	matrix metallopeptidase 14	Homo sapiens	115-122
21942294-7	2012	INNOVATION: Our study demonstrates that curcumin-mediated healing is associated with increased MMP-2, TGF-beta, and VEGF expression and that it plays a pivotal role as an angiogenic modulator by stimulating vascular sprout formation and collagen fiber restoration in ulcerated tissues.	Curcumin	40-48	matrix metallopeptidase 2	Homo sapiens	95-100
25530715-7	2014	Finally, WST-1 assay was tested to explore the concomitant treatment with curcumin and the inhibition of PKB or SKP2 signaling on curcumin sensitivity in MCF-7 and MDA-MB-231 cells.	Curcumin	130-138	S-phase kinase associated protein 2	Homo sapiens	112-116
25530715-8	2014	RESULTS: We demonstrated MCF-7 and MDA-MB-231 cells exhibited differential responses to curcumin by WST-1 and clonogenic assay (MDA-MB-231 cells was sensitive, and MCF-7 cells was resistant), which were found to be related to the differential curcumin-mediated regulation of SKP2-Cip/Kips (p21 and p27 but not p57) signaling.	Curcumin	88-96	S-phase kinase associated protein 2	Homo sapiens	275-279
25530715-10	2014	Importantly, PI3K inhibitor wortmannin could counteract both curcumin-induced phosphorylation of Akt and up-regulation of SKP2 in MCF-7 cells.	Curcumin	61-69	S-phase kinase associated protein 2	Homo sapiens	122-126
22186408-0	2012	Curcumin down-regulates visfatin expression and inhibits breast cancer cell invasion.	Curcumin	0-8	nicotinamide phosphoribosyltransferase	Homo sapiens	24-32
22186408-6	2012	The purpose of this study was to investigate whether visfatin gene expression is affected by curcumin in human breast cancer cells and to characterize the functional role of visfatin in breast cancer.	Curcumin	93-101	nicotinamide phosphoribosyltransferase	Homo sapiens	53-61
25530715-11	2014	Subsequent WST-1 assay demonstrated concomitant treatment with curcumin and wortmannin or SKP2 siRNA not only further augmented curcumin sensitivity in MDA-MB-231 cells but also overcame curcumin resistance in MCF-7 cells.	Curcumin	128-136	S-phase kinase associated protein 2	Homo sapiens	90-94
22186408-7	2012	We found that the mRNA and protein levels of visfatin were down-regulated by curcumin in MDA-MB-231, MDA-MB-468, and MCF-7 breast cancer cells, along with decreased activity of constitutive nuclear factor (NF)-kappaB.	Curcumin	77-85	nicotinamide phosphoribosyltransferase	Homo sapiens	45-53
25530715-11	2014	Subsequent WST-1 assay demonstrated concomitant treatment with curcumin and wortmannin or SKP2 siRNA not only further augmented curcumin sensitivity in MDA-MB-231 cells but also overcame curcumin resistance in MCF-7 cells.	Curcumin	128-136	S-phase kinase associated protein 2	Homo sapiens	90-94
22186408-8	2012	We confirmed the repressive effect of curcumin on visfatin transcription by performing a visfatin promoter-driven reporter assay and identified two putative NF-kappaB-binding sites on visfatin promoter that are important for this effect.	Curcumin	38-46	nicotinamide phosphoribosyltransferase	Homo sapiens	50-58
22186408-8	2012	We confirmed the repressive effect of curcumin on visfatin transcription by performing a visfatin promoter-driven reporter assay and identified two putative NF-kappaB-binding sites on visfatin promoter that are important for this effect.	Curcumin	38-46	nicotinamide phosphoribosyltransferase	Homo sapiens	89-97
25530715-12	2014	CONCLUSIONS: Our study established PI3K/Akt-SKP2-Cip/Kips signaling pathway is involved in the mechanism of action of curcumin and revealed that the discrepant modulation of this pathway by curcumin is responsible for the differential susceptibilities of these two cell types to curcumin.	Curcumin	118-126	S-phase kinase associated protein 2	Homo sapiens	44-48
22186408-8	2012	We confirmed the repressive effect of curcumin on visfatin transcription by performing a visfatin promoter-driven reporter assay and identified two putative NF-kappaB-binding sites on visfatin promoter that are important for this effect.	Curcumin	38-46	nicotinamide phosphoribosyltransferase	Homo sapiens	89-97
22186408-9	2012	EMSA and chromatin immunoprecipitation analysis indicated the binding of p65 to the visfatin promoter, which was effectively blocked by curcumin.	Curcumin	136-144	RELA proto-oncogene, NF-kB subunit	Homo sapiens	73-76
25389660-4	2014	The mechanism of anti-MRSA action of curcumin was analyzed by the viability assay in the presence of detergents, ATPase inhibitors and peptidoglycan (PGN) from S. aureus, and the PBP2a protein level was analyzed by western blotting.	Curcumin	37-45	AT695_RS06370	Staphylococcus aureus	113-119
22186408-9	2012	EMSA and chromatin immunoprecipitation analysis indicated the binding of p65 to the visfatin promoter, which was effectively blocked by curcumin.	Curcumin	136-144	nicotinamide phosphoribosyltransferase	Homo sapiens	84-92
22186408-11	2012	Visfatin could enhance the invasion of MDA-MB-231 cells and also attenuate curcumin-induced inhibition of cell invasion; on the other hand, visfatin knockdown by small interfering RNA led to the reduction of cell invasion.	Curcumin	75-83	nicotinamide phosphoribosyltransferase	Homo sapiens	0-8
22186408-12	2012	Our data demonstrate, for the first time, that curcumin down-regulates visfatin gene expression in human breast cancer cells by a mechanism that is, at least in part, NF-kappaB dependent and suggest that visfatin may contribute to breast cancer cell invasion and link obesity to breast cancer development and progression.	Curcumin	47-55	nicotinamide phosphoribosyltransferase	Homo sapiens	71-79
25389660-12	2014	These data indicate a remarkable antibacterial effect of curcumin, with membrane permeability enhancers and ATPase inhibitors, and curcumin did not directly bind to PGN on the cell wall.	Curcumin	57-65	AT695_RS06370	Staphylococcus aureus	108-114
22144489-8	2012	Dietary administration of 6% pectin or 4% curcumin in C. rodentium-infected mice also inhibited NF-kappaB activity and blocked CD3, F4/80, IL-1alpha/beta, G-CSF/MCP-1/KC, and MPO activity in the CLP while not affecting NF-kappaB activity in the crypts.	Curcumin	42-50	colony stimulating factor 3 (granulocyte)	Mus musculus	155-160
25131506-8	2014	Moreover, pre-treatment with curcumin attenuated LPS-induced microglial activation and overproduction of pro-inflammatory cytokine (interleukin-1beta and tumor necrosis factor-alpha), as well as the levels of inducible nitric oxide synthase and cyclooxygenase-2 mRNA in the hippocampus and prefrontal cortex (PFC).	Curcumin	29-37	prostaglandin-endoperoxide synthase 2	Mus musculus	245-261
21993423-7	2012	Further, differential expression levels of cleaved (ADP) ribose polymerase 1 (PARP-1) and phosphorylated histone H2AX (gamma-H2AX) were observed after curcumin treatment.	Curcumin	151-159	H2A.X variant histone	Homo sapiens	105-117
21993423-7	2012	Further, differential expression levels of cleaved (ADP) ribose polymerase 1 (PARP-1) and phosphorylated histone H2AX (gamma-H2AX) were observed after curcumin treatment.	Curcumin	151-159	H2A.X variant histone	Homo sapiens	119-129
21993423-8	2012	It seems that PARP-1 similar to H2AX, confers cellular protection against radiation and estrogen-induced DNA damage mediated by curcumin.	Curcumin	128-136	H2A.X variant histone	Homo sapiens	32-36
25195681-5	2014	Curcumin also decreased the expression and activity of matrix metalloproteinases (MMP)-2 and MMP-9, and reduced p38 phosphorylation.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	55-88
22129484-6	2012	The transcription of Lin28B is promoted by NF-kappaB and by Myc; hence, practical measures which antagonize NF-kappaB or Myc activity may complement the utility of metformin for boosting let-7 expression and controlling cancer stemness; salsalate, antioxidants, tyrosine kinase and cox-2 inhibitors, ribavirin, vitamin D, gamma-secretase inhibitors (when available), and parenteral curcumin may have some utility in this regard.	Curcumin	382-390	lin-28 homolog B	Mus musculus	21-27
22129484-6	2012	The transcription of Lin28B is promoted by NF-kappaB and by Myc; hence, practical measures which antagonize NF-kappaB or Myc activity may complement the utility of metformin for boosting let-7 expression and controlling cancer stemness; salsalate, antioxidants, tyrosine kinase and cox-2 inhibitors, ribavirin, vitamin D, gamma-secretase inhibitors (when available), and parenteral curcumin may have some utility in this regard.	Curcumin	382-390	myelocytomatosis oncogene	Mus musculus	121-124
21584871-7	2012	In addition, PI3K/Akt/ GSK 3beta, ERK and p38 MAPK were activated by curcumin, while inhibitors of these signals attenuated the inhibitory effects of curcumin on melanogenesis.	Curcumin	69-77	glycogen synthase kinase 3 beta	Homo sapiens	23-32
21584871-8	2012	These results suggest that curcumin inhibits melanogenesis in human melanocytes through activation of Akt/GSK 3beta, ERK or p38 MAPK signaling pathways.	Curcumin	27-35	glycogen synthase kinase 3 beta	Homo sapiens	106-115
23317243-8	2012	Curcumin also markedly inhibited TGF-beta1-regulated MMP-9 and activation of Smad2, ERK1/2 and p38 in a dose- and time-dependent manner.	Curcumin	0-8	SMAD family member 2	Homo sapiens	77-82
25195681-6	2014	Combination treatment of HCC cells with curcumin and SB203580 (a p38 signaling pathway inhibitor), generated a synergistic effect on the expression of MMP-2 and MMP-9, suggesting that the anti-metastatic effect of curcumin on HCC may involve a p38 signaling pathway.	Curcumin	40-48	matrix metallopeptidase 2	Homo sapiens	151-156
25195681-6	2014	Combination treatment of HCC cells with curcumin and SB203580 (a p38 signaling pathway inhibitor), generated a synergistic effect on the expression of MMP-2 and MMP-9, suggesting that the anti-metastatic effect of curcumin on HCC may involve a p38 signaling pathway.	Curcumin	214-222	matrix metallopeptidase 2	Homo sapiens	151-156
22005927-9	2012	CONCLUSION: Curcumin suppresses ox-LDL-induced MCP-1 expression in VSMCs via the p38 MAPK and NF-kappaB pathways, which suggests that the anti-inflammatory effect of curcumin is related to the down-regulation of MCP-1 expression and offers a new theoretical basis in the anti-inflammatory effects of curcumin.	Curcumin	12-20	mitogen activated protein kinase 14	Rattus norvegicus	81-84
22138522-0	2012	Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression.	Curcumin	0-8	toll-like receptor 2	Mus musculus	101-107
24706026-12	2014	The results of the present study suggested that Notch1 and Notch2 receptor, major Notch1 receptor, played an important role in the development of allergic airway inflammation and the inhibition of Notch1-GATA3 signaling pathway by curcumin can prevent the development and deterioration of the allergic airway inflammation.	Curcumin	231-239	notch 2	Mus musculus	59-65
22138522-7	2012	Furthermore, the expression levels of Toll-like receptor (TLR) 2, TLR4 and TLR9 mRNA or protein in liver tissues were significantly lowered by curcumin treatment.	Curcumin	143-151	toll-like receptor 2	Mus musculus	58-64
22138522-10	2012	The beneficial effect of curcumin may be partly mediated by inhibiting the expression levels of TLR2, TLR4 and TLR9 in the liver.	Curcumin	25-33	toll-like receptor 2	Mus musculus	96-100
22679371-5	2012	The results showed that liposomal curcumin inhibited nuclear factor-kappaB pathway and downregulated inflammatory factors including tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, and transforming growth factor-beta induced by thoracic irradiation.	Curcumin	34-42	chemokine (C-X-C motif) ligand 15	Mus musculus	181-185
24963995-13	2014	In both H2O2-treated BV-2 microglia and glaucoma models, caspase 3, cytochrome c, and BAX were downregulated and BCL2 was upregulated in the curcumin-treated group.	Curcumin	141-149	caspase 3	Rattus norvegicus	57-66
22888226-11	2012	In the animal model of asthma, curcumin-SLNs effectively suppressed airway hyperresponsiveness and inflammatory cell infiltration and also significantly inhibited the expression of T-helper-2-type cytokines, such as interleukin-4 and interleukin-13, in bronchoalveolar lavage fluid compared to the asthma group and curcumin-treated group.	Curcumin	31-39	interleukin 4	Rattus norvegicus	216-229
22886017-0	2012	Curcumin-mediated neuroprotection against amyloid-beta-induced mitochondrial dysfunction involves the inhibition of GSK-3beta.	Curcumin	0-8	glycogen synthase kinase 3 beta	Homo sapiens	116-125
22886017-10	2012	Both total GSK-3beta expression and phospho-Ser9 GSK-3beta (pSer9-GSK-3beta) are down-regulated in the cells pre-treated with curcumin.	Curcumin	126-134	glycogen synthase kinase 3 beta	Homo sapiens	11-20
21311958-9	2011	This time-dependent drop in curcumin level was found to be due to induction of CYP1A1 and GSTM (mu) enzymes which led to increased metabolism of curcumin.	Curcumin	28-36	glutathione S-transferase mu 2	Homo sapiens	90-94
21311958-9	2011	This time-dependent drop in curcumin level was found to be due to induction of CYP1A1 and GSTM (mu) enzymes which led to increased metabolism of curcumin.	Curcumin	145-153	glutathione S-transferase mu 2	Homo sapiens	90-94
22886017-10	2012	Both total GSK-3beta expression and phospho-Ser9 GSK-3beta (pSer9-GSK-3beta) are down-regulated in the cells pre-treated with curcumin.	Curcumin	126-134	glycogen synthase kinase 3 beta	Homo sapiens	49-58
24651933-7	2014	The increased phosphorylation of p38 and JNK induced by OGD was decreased under the treatment of curcumin, whereas the p38 inhibitor, SB203580, significantly inhibited OGD-induced IL-1beta production, but the JNK inhibitor, SP600125, failed to do so.	Curcumin	97-105	mitogen activated protein kinase 14	Rattus norvegicus	33-36
22886017-10	2012	Both total GSK-3beta expression and phospho-Ser9 GSK-3beta (pSer9-GSK-3beta) are down-regulated in the cells pre-treated with curcumin.	Curcumin	126-134	glycogen synthase kinase 3 beta	Homo sapiens	49-58
22886017-12	2012	Inhibition of GSK-3beta is involved in the protection of curcumin against Abeta-induced mitochondrial dysfunction.	Curcumin	57-65	glycogen synthase kinase 3 beta	Homo sapiens	14-23
21842651-6	2011	RESULT: The expression of ATP synthesis H+ transporting, MHC class II, non-muscle myosin alkali light chain and cytochrome b5 increased in the RAW264.7 cell treated with 25 micromol x L(-1) curcumin, while the expression of phosphodiesterase 4D, elF-3, Hnrpf protein, vimentin, nucleophosminl and Ranbp 1 decreased.	Curcumin	190-198	cytochrome b5 type A (microsomal)	Mus musculus	112-125
24651933-8	2014	These results suggest that the inhibition of IL-1beta by curcumin may dependent on the p38 signaling pathway.	Curcumin	57-65	mitogen activated protein kinase 14	Rattus norvegicus	87-90
25230870-16	2014	Mechanism of effect of curcumin on MPT may be related to reduction of intracellular calcium concentration, promotion of anti-apoptotic Bcl-2 gene expression, inhibition of caspase-3 activation and Bax gene.	Curcumin	23-31	caspase 3	Rattus norvegicus	172-181
21443863-2	2011	Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4(+) T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 (alpha chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28.	Curcumin	47-55	CD3 antigen, epsilon polypeptide	Mus musculus	262-265
21443863-5	2011	IL-2-induced phosphorylation of STAT5A and JAK3, but not JAK1, was diminished in the presence of curcumin, indicating inhibition of critical proximal events in IL-2R signaling.	Curcumin	97-105	Janus kinase 3	Mus musculus	43-47
25170806-0	2014	Curcumin promotes KLF5 proteasome degradation through downregulating YAP/TAZ in bladder cancer cells.	Curcumin	0-8	Kruppel-like factor 5	Mus musculus	18-22
25170806-0	2014	Curcumin promotes KLF5 proteasome degradation through downregulating YAP/TAZ in bladder cancer cells.	Curcumin	0-8	yes-associated protein 1	Mus musculus	69-72
25170806-2	2014	In this study, we demonstrated that curcumin targeted KLF5 by promoting its proteasome degradation, but not by inhibiting its transcription in bladder cancer cells.	Curcumin	36-44	Kruppel-like factor 5	Mus musculus	54-58
25170806-3	2014	We also demonstrated that lentivirus-based knockdown of KLF5 inhibited cancer cell growth, while over-expression of a Flag-tagged KLF5 could partially reverse the effects of curcumin on cell growth and cyclin D1 expression.	Curcumin	174-182	Kruppel-like factor 5	Mus musculus	130-134
25170806-4	2014	Furthermore, we found that curcumin could down-regulate the expression of Hippo pathway effectors, YAP and TAZ, which have been reported to protect KLF5 protein from degradation.	Curcumin	27-35	yes-associated protein 1	Mus musculus	99-102
25170806-4	2014	Furthermore, we found that curcumin could down-regulate the expression of Hippo pathway effectors, YAP and TAZ, which have been reported to protect KLF5 protein from degradation.	Curcumin	27-35	Kruppel-like factor 5	Mus musculus	148-152
21352912-0	2011	Curcumin activates Wnt/beta-catenin signaling pathway through inhibiting the activity of GSK-3beta in APPswe transfected SY5Y cells.	Curcumin	0-8	glycogen synthase kinase 3 beta	Homo sapiens	89-98
25170806-7	2014	Thus, our data indicates that curcumin promotes KLF5 proteasome-dependent degradation through targeting YAP/TAZ in bladder cancer cells and also suggests the therapeutic potential of curcumin in the treatment of bladder cancer.	Curcumin	30-38	Kruppel-like factor 5	Mus musculus	48-52
21352912-2	2011	The study aims to investigate the effect of Curcumin on the expression of GSK-3beta, beta-catenin and CyclinD1 in vitro, which are tightly correlated with Wnt/beta-catenin signaling pathway, and also to explore the mechanisms, which will provide a novel therapeutic intervention for treatment of Alzheimer"s disease.	Curcumin	44-52	glycogen synthase kinase 3 beta	Homo sapiens	74-83
25170806-7	2014	Thus, our data indicates that curcumin promotes KLF5 proteasome-dependent degradation through targeting YAP/TAZ in bladder cancer cells and also suggests the therapeutic potential of curcumin in the treatment of bladder cancer.	Curcumin	30-38	yes-associated protein 1	Mus musculus	104-107
21352912-2	2011	The study aims to investigate the effect of Curcumin on the expression of GSK-3beta, beta-catenin and CyclinD1 in vitro, which are tightly correlated with Wnt/beta-catenin signaling pathway, and also to explore the mechanisms, which will provide a novel therapeutic intervention for treatment of Alzheimer"s disease.	Curcumin	44-52	cyclin D1	Homo sapiens	102-110
25170806-7	2014	Thus, our data indicates that curcumin promotes KLF5 proteasome-dependent degradation through targeting YAP/TAZ in bladder cancer cells and also suggests the therapeutic potential of curcumin in the treatment of bladder cancer.	Curcumin	183-191	Kruppel-like factor 5	Mus musculus	48-52
21352912-5	2011	Cell lysates were collected for RT-PCR, Western blot assay and immunofluorescent staining were carried out for detecting the effect of Curcumin on the expression of GSK-3beta, beta-catenin and CyclinD1.	Curcumin	135-143	glycogen synthase kinase 3 beta	Homo sapiens	165-174
21352912-6	2011	RT-PCR and Western blot results showed that the expression of GSK-3beta mRNA and protein significantly decreased in the transfected cells treated with Curcumin, and that the changes were in a dose and time-dependent manner (P&lt;0.05); however, the protein expression of GSK-3beta-Ser9 was increased (P&lt;0.05).	Curcumin	151-159	glycogen synthase kinase 3 beta	Homo sapiens	62-71
25016646-8	2014	Western blotting study revealed that the induction apoptosis of S-65 cancer cells by curcumin micelles was mainly due to the down-regulation of p-Rb, Blc-2, p-AKT expression and caspase-9 activation.	Curcumin	85-93	caspase 9	Mus musculus	178-187
21352912-6	2011	RT-PCR and Western blot results showed that the expression of GSK-3beta mRNA and protein significantly decreased in the transfected cells treated with Curcumin, and that the changes were in a dose and time-dependent manner (P&lt;0.05); however, the protein expression of GSK-3beta-Ser9 was increased (P&lt;0.05).	Curcumin	151-159	glycogen synthase kinase 3 beta	Homo sapiens	271-280
21352912-10	2011	Curcumin could activate the Wnt/beta-catenin signaling pathway through inhibiting the expression of GSK-3beta and inducing the expression of beta-catenin and CyclinD1, which will provide a new theory for treatment of neurodegenerative diseases by Curcumin.	Curcumin	0-8	glycogen synthase kinase 3 beta	Homo sapiens	100-109
25847272-0	2014	Curcumin and trans-resveratrol exert cell cycle-dependent radioprotective or radiosensitizing effects as elucidated by the PCC and G2-assay.	Curcumin	0-8	crystallin gamma D	Homo sapiens	123-126
21609281-8	2011	Decreased activities of hepatic glutathione reductase and glutathione-S-transferase caused by the lithogenic diet were countered by the combination of capsaicin and curcumin.	Curcumin	165-173	glutathione reductase	Mus musculus	32-53
25289117-7	2014	Also, curcumin stimulates proliferation of SC-NPCs via the MAP kinase signaling pathway, especially involving the p-ERK and p-38 protein.	Curcumin	6-14	mitogen activated protein kinase 14	Rattus norvegicus	124-128
25289117-8	2014	The p-ERK protein and p38 protein levels varied depending on curcumin dosage (0.5 and 1 microM, p&lt;0.05).	Curcumin	61-69	mitogen activated protein kinase 14	Rattus norvegicus	22-25
20857431-0	2011	Role of alpha class glutathione transferases (GSTs) in chemoprevention: GSTA1 and A4 overexpressing human leukemia (HL60) cells resist sulforaphane and curcumin induced toxicity.	Curcumin	152-160	glutathione S-transferase alpha 1	Homo sapiens	46-50
25289117-9	2014	CONCLUSION: Curcumin can stimulate proliferation of SC-NPCs via ERKs and the p38 signaling pathway in low concentrations.	Curcumin	12-20	mitogen activated protein kinase 14	Rattus norvegicus	77-80
20857431-0	2011	Role of alpha class glutathione transferases (GSTs) in chemoprevention: GSTA1 and A4 overexpressing human leukemia (HL60) cells resist sulforaphane and curcumin induced toxicity.	Curcumin	152-160	glutathione S-transferase alpha 1	Homo sapiens	72-77
25031810-0	2014	The Attenuation of Pain Behavior and Serum COX-2 Concentration by Curcumin in a Rat Model of Neuropathic Pain.	Curcumin	66-74	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	43-48
21085975-3	2011	Complex of curcumin with phosphatidyl choline (PC) was prepared and characterized on the basis of TLC, DSC, melting point and IR spectroscopic analysis.	Curcumin	11-19	declival sulcus of cerebellum	Mus musculus	103-106
25031810-9	2014	RESULTS: Curcumin (50 mg/kg) decreased mechanical and cold allodynia (P &lt; 0.001) and produced a decline in serum COX-2 level (P &lt; 0.001).	Curcumin	9-17	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	116-121
21372035-3	2011	Curcumin reduces mucosal concentrations of PGE2 (via inhibition of cyclooxygenases 1 and 2) and 5-HETE (via inhibition of 5-lipoxygenase) in rats.	Curcumin	0-8	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	67-90
25031810-10	2014	CONCLUSIONS: A considerable decline in pain behavior and serum COX-2 levels was seen in rat following administration of curcumin in CCI model of neuropathic pain.	Curcumin	120-128	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	63-68
21282356-3	2011	In this study, we report for the first time that curcumin induces endoplasmic reticulum (ER) stress in human liposarcoma cells via interacting with sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 2 (SERCA2).	Curcumin	49-57	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	148-198
21282356-3	2011	In this study, we report for the first time that curcumin induces endoplasmic reticulum (ER) stress in human liposarcoma cells via interacting with sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 2 (SERCA2).	Curcumin	49-57	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	200-206
21282356-5	2011	Curcumin-mediated ER stress via inhibiting the activity of SERCA2 caused increasing expressions of CHOP and its transcription target death receptor 5 (TRAIL-R2), leading to a caspase-3 and caspase-8 cascade-dependent apoptosis in SW872 cells in vitro and in vivo.	Curcumin	0-8	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	59-65
21282356-5	2011	Curcumin-mediated ER stress via inhibiting the activity of SERCA2 caused increasing expressions of CHOP and its transcription target death receptor 5 (TRAIL-R2), leading to a caspase-3 and caspase-8 cascade-dependent apoptosis in SW872 cells in vitro and in vivo.	Curcumin	0-8	caspase 8	Homo sapiens	189-198
21282356-7	2011	Curcumin dose-dependently inhibited the activity of SERCA2, and the interaction of molecular docking and colocalization in ER of curcumin with SERCA2 were further observed.	Curcumin	0-8	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	52-58
21282356-7	2011	Curcumin dose-dependently inhibited the activity of SERCA2, and the interaction of molecular docking and colocalization in ER of curcumin with SERCA2 were further observed.	Curcumin	0-8	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	143-149
21282356-7	2011	Curcumin dose-dependently inhibited the activity of SERCA2, and the interaction of molecular docking and colocalization in ER of curcumin with SERCA2 were further observed.	Curcumin	129-137	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	52-58
21282356-7	2011	Curcumin dose-dependently inhibited the activity of SERCA2, and the interaction of molecular docking and colocalization in ER of curcumin with SERCA2 were further observed.	Curcumin	129-137	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	143-149
21282356-8	2011	These findings suggest that curcumin may serve as a potent agent for curing human liposarcoma via targeting SERCA2.	Curcumin	28-36	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	108-114
21311744-0	2011	Effect of curcumin on the modulation of alphaA- and alphaB-crystallin and heat shock protein 70 in selenium-induced cataractogenesis in Wistar rat pups.	Curcumin	10-18	crystallin, alpha B	Rattus norvegicus	52-69
21311744-1	2011	PURPOSE: To investigate the expression of alphaA- and alphaB-crystallin and heat shock protein 70 (Hsp 70) during curcumin treatment of selenium-induced cataractogenesis in Wistar rat pups.	Curcumin	114-122	crystallin, alpha B	Rattus norvegicus	42-71
21311744-9	2011	In contrast, in group V, the presence of curcumin 24 h before selenium injection decreased the alphaA- and alphaB-crystallin and Hsp 70 levels to almost the same as those found in group I lenses.	Curcumin	41-49	crystallin, alpha B	Rattus norvegicus	107-135
21134073-6	2011	Combined treatment of isoflavones and curcumin additively suppressed cellular proliferation and induced phosphorylation of ATM, histone H2AX, Chk2 and p53.	Curcumin	38-46	H2A.X variant histone	Homo sapiens	136-140
21134073-6	2011	Combined treatment of isoflavones and curcumin additively suppressed cellular proliferation and induced phosphorylation of ATM, histone H2AX, Chk2 and p53.	Curcumin	38-46	checkpoint kinase 2	Homo sapiens	142-146
21094287-6	2011	Furthermore, curcumin decreased iNOS tyrosine phosphorylation through inhibiting ERK 1/2 activation and subsequently suppressed iNOS enzyme activity.	Curcumin	13-21	mitogen-activated protein kinase 3	Mus musculus	81-88
21084858-0	2011	Inhibition of tumor growth and vasculogenic mimicry by curcumin through down-regulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model.	Curcumin	55-63	Eph receptor A2	Mus musculus	95-100
21084858-8	2011	In conclusion, curcumin has the ability to inhibit the growth of engrafted melanoma VM channels through the regulation of vasculogenic factors that could be related to the down-regulation of the EphA2/PI3K/MMPs signaling pathway.	Curcumin	15-23	Eph receptor A2	Mus musculus	195-200
21415532-11	2011	Curcumin also significantly inhibited the expression of MCP-1 and IL-2 mRNA in HK-2 cells, and partially inhibited the secretion of MCP-1 and IL-8.	Curcumin	0-8	chemokine (C-X-C motif) ligand 15	Mus musculus	142-146
20303727-5	2011	Overexpression of c-Jun, but not c-Fos, decreased ~40% of NPM/B23 and enhanced the sensitivity of NIH 3T3 cells to 30 muM curcumin.	Curcumin	122-130	jun proto-oncogene	Mus musculus	18-23
21343666-6	2011	Also, curcumin inhibited both I(Kv) (IC(50), 11.9 microM) and I(SK4) (IC(50), 4.2 microM).	Curcumin	6-14	potassium calcium-activated channel subfamily N member 4	Homo sapiens	64-67
21437112-0	2010	Curcumin improves prostanoid ratio in diabetic mesenteric arteries associated with cyclooxygenase-2 and NF-kappaB suppression.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	83-99
21437112-2	2010	Curcumin has been reviewed for its multiple molecular action on inhibiting tumor angiogenesis via its mechanisms of cyclooxygenase (COX)-2, and vascular endothelial growth factor (VEGF) inhibition.	Curcumin	0-8	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	116-138
21437112-3	2010	In this present study, we aimed to assess the effects of curcumin on preventing diabetes-induced vascular dysfunction in association with COX-2, nuclear factor-kappaB (NF-kappaB) expression, and prostanoid production.	Curcumin	57-65	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	138-143
21437112-12	2010	CONCLUSION: These findings show that curcumin can attenuate diabetes-induced vascular dysfunction in association with its potential for COX-2 and NF-kappaB suppression, PKC inhibition, and improving the ratio of prostanoid products PGI(2)/TXA(2).	Curcumin	37-45	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	136-141
20729913-0	2010	Identification of Siah-interacting protein as a potential regulator of apoptosis and curcumin resistance.	Curcumin	85-93	calcyclin binding protein	Homo sapiens	18-42
20729913-2	2010	Here we employed proteomic approach to identify the Siah-interacting protein (SIP) as a candidate for detailed study, because the spot intensity of SIP on a two-dimensional gel displayed 70-90% reduction in curcumin-sensitive cells, but remained unchanged in curcumin-resistant sublines, after curcumin treatment.	Curcumin	207-215	calcyclin binding protein	Homo sapiens	52-76
20729913-2	2010	Here we employed proteomic approach to identify the Siah-interacting protein (SIP) as a candidate for detailed study, because the spot intensity of SIP on a two-dimensional gel displayed 70-90% reduction in curcumin-sensitive cells, but remained unchanged in curcumin-resistant sublines, after curcumin treatment.	Curcumin	259-267	calcyclin binding protein	Homo sapiens	52-76
20729913-2	2010	Here we employed proteomic approach to identify the Siah-interacting protein (SIP) as a candidate for detailed study, because the spot intensity of SIP on a two-dimensional gel displayed 70-90% reduction in curcumin-sensitive cells, but remained unchanged in curcumin-resistant sublines, after curcumin treatment.	Curcumin	259-267	calcyclin binding protein	Homo sapiens	52-76
21138870-0	2010	Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway.	Curcumin	8-16	Janus kinase 1	Mus musculus	90-96
21138870-6	2010	RESULTS: In vitro, curcumin inhibited JAK1,2/STAT3 tyrosine-phosphorylation in a dose-dependent fashion in murine glioma cell lines.	Curcumin	19-27	Janus kinase 1	Mus musculus	38-44
21138870-7	2010	Real-time RT-PCR revealed that curcumin downregulated transcription of the STAT3 target genes c-Myc, MMP-9, Snail, and Twist, and of the proliferation marker Ki67.	Curcumin	31-39	matrix metallopeptidase 9	Mus musculus	101-106
21311680-7	2010	Moreover, decreased (cyclin A) and increased (p21 and p27) expression of these E2F4 downstream genes by curcumin was restored by pretreatment of cells with NAC and E2F4 overexpression which is induced by doxycycline.	Curcumin	104-112	E2F transcription factor 4	Homo sapiens	79-83
21311680-7	2010	Moreover, decreased (cyclin A) and increased (p21 and p27) expression of these E2F4 downstream genes by curcumin was restored by pretreatment of cells with NAC and E2F4 overexpression which is induced by doxycycline.	Curcumin	104-112	E2F transcription factor 4	Homo sapiens	164-168
21311680-8	2010	In addition, E2F4 overexpression was observed to partially ameliorate curcumin-induced growth inhibition by cell viability assay.	Curcumin	70-78	E2F transcription factor 4	Homo sapiens	13-17
21311680-9	2010	Taken together, we found curcumin-induced ROS down-regulation of E2F4 expression and modulation of E2F4 target genes which finally lead to the apoptotic cell death in HCT116 colon cancer cells, suggesting that E2F4 appears to be a novel determinant of curcumin-induced cytotoxicity.	Curcumin	25-33	E2F transcription factor 4	Homo sapiens	65-69
21311680-9	2010	Taken together, we found curcumin-induced ROS down-regulation of E2F4 expression and modulation of E2F4 target genes which finally lead to the apoptotic cell death in HCT116 colon cancer cells, suggesting that E2F4 appears to be a novel determinant of curcumin-induced cytotoxicity.	Curcumin	25-33	E2F transcription factor 4	Homo sapiens	99-103
21311680-9	2010	Taken together, we found curcumin-induced ROS down-regulation of E2F4 expression and modulation of E2F4 target genes which finally lead to the apoptotic cell death in HCT116 colon cancer cells, suggesting that E2F4 appears to be a novel determinant of curcumin-induced cytotoxicity.	Curcumin	25-33	E2F transcription factor 4	Homo sapiens	99-103
19908170-0	2010	Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells.	Curcumin	0-8	microRNA 15a	Homo sapiens	57-64
19908170-3	2010	In our study, we confirmed that the expression of miR-15a and miR-16 was upregulated and that of Bcl-2 was downregulated in curcumin-treated MCF-7 cells.	Curcumin	124-132	microRNA 15a	Homo sapiens	50-57
19908170-5	2010	Thus, we concluded that curcumin can reduce the expression of Bcl-2 by upregulating the expression of miR-15a and miR-16 in MCF-7 cells.	Curcumin	24-32	microRNA 15a	Homo sapiens	102-109
20958191-8	2010	Curcumin inhibited RPE cell increase exclusively by inducing caspase 3/7-dependent but caspase 8-independent cell death and necrosis.	Curcumin	0-8	caspase 8	Homo sapiens	87-96
20920780-6	2010	In addition, the stress-induced increase in the expression of constitutive nitric oxide synthase (cNOS) and enzyme activities of total NOS, cNOS, and inducible NOS (iNOS) was also reversed or attenuated in curcumin-treated pigs.	Curcumin	206-214	nitric oxide synthase 3	Sus scrofa	98-102
20920780-6	2010	In addition, the stress-induced increase in the expression of constitutive nitric oxide synthase (cNOS) and enzyme activities of total NOS, cNOS, and inducible NOS (iNOS) was also reversed or attenuated in curcumin-treated pigs.	Curcumin	206-214	nitric oxide synthase 3	Sus scrofa	140-144
20878089-10	2010	Curcumin induced the unfolding protein response by down-regulating the protein expressions of Calnexin, PDI and Ero1-Lalpha and up-regulating the Calreticulin expression.	Curcumin	0-8	calnexin	Homo sapiens	94-102
20854995-12	2010	Microsomal cytochrome P450 2C activity was inhibited by treatment with curcumin or ticlopidine, whereas cytochrome P450 3A activity was inhibited by treatment with curcumin or diltiazem.	Curcumin	71-79	cytochrome P450, family 2, subfamily C, polypeptide 19	Bos taurus	11-29
19826913-4	2010	The objective of this study was to exam the curcumin cytotoxic effect and modulation of two major rate-limiting translation initiation factors, including eIF2alpha and eIF4E protein expression levels in lung adenocarcinoma epithelial cell line A549.	Curcumin	44-52	eukaryotic translation initiation factor 4E	Homo sapiens	168-173
19826913-9	2010	These findings suggest that curcumin could reduce cell viability through prohibiting the initiation of protein synthesis by modulating eIF2alpha and eIF4E.	Curcumin	28-36	eukaryotic translation initiation factor 4E	Homo sapiens	149-154
20885979-8	2010	We found Curcumin decreased the levels of D-lactate, DAO, MPO, ICAM-1, IL-1beta and TNF-alpha, but increased the levels of IL-10 and SOD in rat models.	Curcumin	9-17	amine oxidase, copper containing 1	Rattus norvegicus	53-56
20885979-9	2010	We further confirmed mitogen-activated protein kinase phosphatase-1 (MKP-1) was activated but phospho-p38 was inhibited by curcumin by western blot assay.	Curcumin	123-131	mitogen activated protein kinase 14	Rattus norvegicus	102-105
20885979-12	2010	CONCLUSIONS/SIGNIFICANCE: The effect of curcumin is mediated by the MKP-1-dependent inactivation of p38 and inhibition of NF-kappaB-mediated transcription.	Curcumin	40-48	mitogen activated protein kinase 14	Rattus norvegicus	100-103
20538607-5	2010	Results of Sp1, Sp3, and Sp4 knockdown by RNA interference demonstrate that both p50 and p65 are Sp-regulated genes and that inhibition of constitutive or tumor necrosis factor-induced NFkappaB by curcumin is dependent on down-regulation of Sp1, Sp3, and Sp4 proteins by this compound.	Curcumin	197-205	RELA proto-oncogene, NF-kB subunit	Homo sapiens	89-92
20638958-6	2010	The results demonstrated that the contents of activated caspase-3 increased significantly by iAbeta, while curcumin significantly inhibited the iAbeta-induced increases of activated caspase-3 tested by Western blot.	Curcumin	107-115	caspase 3	Rattus norvegicus	182-191
20638958-8	2010	The results suggest that curcumin may play a protective effect in primary cultured rat prefrontal cortical neurons against iAbeta-induced cytotoxicity, and both AKT and caspase-3 are involved in the curcumin-induced protective effects.	Curcumin	199-207	caspase 3	Rattus norvegicus	169-178
20590660-0	2010	Curcumin disrupts meiotic and mitotic divisions via spindle impairment and inhibition of CDK1 activity.	Curcumin	0-8	cyclin-dependent kinase 1	Mus musculus	89-93
20590660-9	2010	Our analysis indicated that curcumin affects CDK1 kinase activity but does not directly affect microtubule polymerization and tubulin acetylation.	Curcumin	28-36	cyclin-dependent kinase 1	Mus musculus	45-49
20514428-0	2010	Curcumin suppresses alpha-melanocyte stimulating hormone-stimulated melanogenesis in B16F10 cells.	Curcumin	0-8	pro-opiomelanocortin-alpha	Mus musculus	20-56
20514428-1	2010	The present study was designed to assess the potential inhibitory activity of curcumin on the alpha-melanocyte stimulating hormone (alpha-MSH)-stimulated melanogenesis signal pathway in B16F10 melanoma cells.	Curcumin	78-86	pro-opiomelanocortin-alpha	Mus musculus	94-130
20514428-1	2010	The present study was designed to assess the potential inhibitory activity of curcumin on the alpha-melanocyte stimulating hormone (alpha-MSH)-stimulated melanogenesis signal pathway in B16F10 melanoma cells.	Curcumin	78-86	pro-opiomelanocortin-alpha	Mus musculus	132-141
20514428-2	2010	The molecular mechanism of curcumin-induced inhibitory activity on the alpha-MSH-stimulated melanogenesis signal pathway, including expression of melanogenesis-related proteins and activation of melanogenesis-regulating proteins, was examined in B16F10 cells.	Curcumin	27-35	pro-opiomelanocortin-alpha	Mus musculus	71-80
20514428-3	2010	Curcumin suppressed the cellular melanin contents and the tyrosinase activity in alpha-MSH-stimulated B16F10 cells.	Curcumin	0-8	pro-opiomelanocortin-alpha	Mus musculus	81-90
20514428-4	2010	In addition, the expression of melanogenesis-related proteins such as microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein 1 and 2 was suppressed by curcumin in the alpha-MSH-stimulated B16F10 cells.	Curcumin	194-202	pro-opiomelanocortin-alpha	Mus musculus	210-219
20514428-5	2010	Notably, a melanogenesis-regulating signal such as mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) or phosphatidylinositol 3-kinase (PI3K)/Akt was activated by curcumin in the B16F10 cells treated with or without alpha-MSH.	Curcumin	202-210	midkine	Mus musculus	51-90
20514428-5	2010	Notably, a melanogenesis-regulating signal such as mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) or phosphatidylinositol 3-kinase (PI3K)/Akt was activated by curcumin in the B16F10 cells treated with or without alpha-MSH.	Curcumin	202-210	midkine	Mus musculus	92-95
20514428-5	2010	Notably, a melanogenesis-regulating signal such as mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) or phosphatidylinositol 3-kinase (PI3K)/Akt was activated by curcumin in the B16F10 cells treated with or without alpha-MSH.	Curcumin	202-210	pro-opiomelanocortin-alpha	Mus musculus	255-264
20514428-6	2010	The suppressive activity of curcumin on alpha-MSH-induced melanogenesis was down-regulated by PD98059 and by LY294002.	Curcumin	28-36	pro-opiomelanocortin-alpha	Mus musculus	40-49
20514428-7	2010	Our results suggest that the suppressive activity of curcumin on alpha-MSH-stimulated melanogenesis may involve the down-regulation of MITF and its downstream signal pathway through the activation of MEK/ERK or PI3K/Akt.	Curcumin	53-61	pro-opiomelanocortin-alpha	Mus musculus	65-74
20514428-7	2010	Our results suggest that the suppressive activity of curcumin on alpha-MSH-stimulated melanogenesis may involve the down-regulation of MITF and its downstream signal pathway through the activation of MEK/ERK or PI3K/Akt.	Curcumin	53-61	midkine	Mus musculus	200-203
20651361-9	2010	Curcumin-induced apoptosis was also stimulated through the FAS/caspase-8 (extrinsic) pathway and ER stress proteins, growth arrest- and DNA damage-inducible gene 153 (GADD153) and glucose-regulated protein 78 (GRP78) were activated in the NCI-H460 cells.	Curcumin	0-8	caspase 8	Homo sapiens	63-72
20651361-10	2010	Apoptotic cell death induced by curcumin was significantly reversed by pretreatment with ROS scavenger or caspase-8 inhibitor.	Curcumin	32-40	caspase 8	Homo sapiens	106-115
20222050-5	2010	Moreover, curcumin increased phosphorylation of hepatic janus-activated kinase-signal transducer 2 and subsequently also stimulated Akt and ERK1/2 activation in this model.	Curcumin	10-18	mitogen activated protein kinase 3	Rattus norvegicus	140-146
20332524-7	2010	Curcumin-similar to PPARgamma synthetic agonist troglitazone-directly inhibited TNF-alpha-induced inflammatory activation of cholangiocytes in vitro, whereas these beneficial effects of curcumin were largely blocked by a PPARgamma synthetic antagonist.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	221-230
20422739-3	2010	We postulated that curcumin may reduce Ang II-mediated cardiomyocyte growth via AT1R and LOX-1 inhibition.	Curcumin	19-27	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	39-42
20422739-7	2010	RESULTS: Curcumin (5-10 microM), losartan, and anti-LOX-1 antibody markedly attenuated Ang II-mediated oxidant stress, and the expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and nuclear factor-kappaB (NF-kappaB).	Curcumin	9-17	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	87-90
20422739-8	2010	Attenuation of redox state by curcumin resulted in abrogation of Ang II-mediated cardiomyocyte growth and atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes.	Curcumin	30-38	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	65-68
20422739-9	2010	Curcumin also reduced Ang II-mediated upregulation of AT1R and LOX-1.	Curcumin	0-8	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	22-25
20422739-11	2010	CONCLUSIONS: Curcumin attenuates Ang II-mediated cardiomyocyte growth by inhibiting LOX-1 and AT1R expression and suppressing the heightened intracellular redox state.	Curcumin	13-21	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	33-36
20145189-7	2010	In the immortalized, leukoplakia, and cancer cells, curcumin inhibited cap-dependent translation by suppressing the phosphorylation of 4E-BP1, eIF4G, eIF4B, and Mnk1, and also reduced the total levels of eIF4E and Mnk1.	Curcumin	52-60	eukaryotic translation initiation factor 4E	Homo sapiens	204-209
19444642-0	2010	Curcumin decreases the expression of Pokemon by suppressing the binding activity of the Sp1 protein in human lung cancer cells.	Curcumin	0-8	zinc finger and BTB domain containing 7A	Homo sapiens	37-44
19444642-4	2010	To investigate whether curcumin can regulate the expression of Pokemon, a series of experiments were carried out.	Curcumin	23-31	zinc finger and BTB domain containing 7A	Homo sapiens	63-70
19444642-5	2010	Transient transfection experiments demonstrated that curcumin could decrease the activity of the Pokemon promoter.	Curcumin	53-61	zinc finger and BTB domain containing 7A	Homo sapiens	97-104
19444642-6	2010	Western blot analysis suggested that curcumin could significantly decrease the expression of the Pokemon.	Curcumin	37-45	zinc finger and BTB domain containing 7A	Homo sapiens	97-104
19444642-8	2010	More important, we also found that curcumin could decrease the expression of the Pokemon by suppressing the stimulation of the Sp1 protein.	Curcumin	35-43	zinc finger and BTB domain containing 7A	Homo sapiens	81-88
19444642-9	2010	Therefore, curcumin is a potential reagent for tumour therapy which may target Pokemon.	Curcumin	11-19	zinc finger and BTB domain containing 7A	Homo sapiens	79-86
20332435-5	2010	However, inclusion of curcumin to continued FOLFOX treatment for another 48 h greatly reduced the survival of these cells, accompanied by a concomitant reduction in activation of EGFR, HER-2, IGF-1R and AKT, as well as expression of COX-2 and cyclin-D1.	Curcumin	22-30	prostaglandin-endoperoxide synthase 2	Mus musculus	233-238
20332435-5	2010	However, inclusion of curcumin to continued FOLFOX treatment for another 48 h greatly reduced the survival of these cells, accompanied by a concomitant reduction in activation of EGFR, HER-2, IGF-1R and AKT, as well as expression of COX-2 and cyclin-D1.	Curcumin	22-30	cyclin D1	Homo sapiens	243-252
19935077-3	2010	We postulated that curcumin may reduce Ang II-mediated cardiomyocyte growth via AT1R and LOX-1 inhibition.	Curcumin	19-27	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	39-42
19935077-7	2010	RESULTS: Curcumin (5-10 microM), losartan, and anti-LOX-1 antibody markedly attenuated Ang II-mediated oxidant stress, and the expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and nuclear factor-kappaB (NF-kappaB).	Curcumin	9-17	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	87-90
19935077-8	2010	Attenuation of redox state by curcumin resulted in abrogation of Ang II-mediated cardiomyocyte growth and atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes.	Curcumin	30-38	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	65-68
19935077-9	2010	Curcumin also reduced Ang II-mediated upregulation of AT1R and LOX-1.	Curcumin	0-8	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	22-25
19935077-11	2010	CONCLUSIONS: Curcumin attenuates Ang II-mediated cardiomyocyte growth by inhibiting LOX-1 and AT1R expression and suppressing the heightened intracellular redox state.	Curcumin	13-21	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	33-36
20230279-5	2010	Most importantly, curcumin treatment significantly inhibited MPTP/MPP(+)-induced phosphorylation of JNK1/2 and c-Jun, and cleaved caspase-3.	Curcumin	18-26	jun proto-oncogene	Mus musculus	111-116
19682434-8	2010	Curcumin also significantly decreased the proliferation marker Ki-67 and microvessel density (CD31) (P&lt;0.01 versus vehicle; P&lt;0.01 versus gemcitabine alone), but maximum reduction occurred when it was combined with gemcitabine (P&lt;0.01 versus vehicle; P&lt;0.01 versus gemcitabine alone).	Curcumin	0-8	platelet and endothelial cell adhesion molecule 1	Homo sapiens	94-98
19682434-9	2010	Curcumin abolished the constitutive activation of NF-kappaB in the tumor tissue; induced apoptosis, and decreased cyclin D1, VEGF, COX-2, c-myc and Bcl-2 expression in the bladder cancer tissue.	Curcumin	0-8	cyclin D1	Homo sapiens	114-123
20160437-6	2010	Curcumin suppressed not only TGF-beta(1)-induced Smad2 phosphorylation in a dose- and time-dependent manner, but also the nuclear accumulation of receptor-regulated Smads (R-Smad), Smad2 and Smad3.	Curcumin	0-8	SMAD family member 2	Homo sapiens	49-54
20160437-6	2010	Curcumin suppressed not only TGF-beta(1)-induced Smad2 phosphorylation in a dose- and time-dependent manner, but also the nuclear accumulation of receptor-regulated Smads (R-Smad), Smad2 and Smad3.	Curcumin	0-8	SMAD family member 2	Homo sapiens	181-186
20160437-6	2010	Curcumin suppressed not only TGF-beta(1)-induced Smad2 phosphorylation in a dose- and time-dependent manner, but also the nuclear accumulation of receptor-regulated Smads (R-Smad), Smad2 and Smad3.	Curcumin	0-8	SMAD family member 3	Homo sapiens	191-196
20838026-0	2010	Curcumin Inhibits the proteinase-activated receptor-2-triggered prostaglandin E2 production by suppressing cyclooxygenase-2 upregulation and Akt-dependent activation of nuclear factor-kappaB in human lung epithelial cells.	Curcumin	0-8	F2R like trypsin receptor 1	Homo sapiens	22-53
20358476-6	2010	Caspase-3, caspase-8, and caspase-9 were activated, and cytochrome c and apoptosis-inducing factor (AIF) were released from mitochondria following curcumin treatment.	Curcumin	147-155	caspase 8	Homo sapiens	11-20
19726538-9	2009	In endocrine pituitary tumour cell lines, GH, ACTH and prolactin production were inhibited by curcumin.	Curcumin	94-102	pro-opiomelanocortin-alpha	Mus musculus	46-50
19762916-4	2009	Members of the activator protein 1 (AP-1) and specificity protein 1 (Sp1) family of transcription factors are necessary for the transcriptional regulation of the XYLT1 gene, which was proven by curcumin, tanshinone IIA, mithramycin A, and short interference RNA treatment.	Curcumin	194-202	xylosyltransferase 1	Homo sapiens	162-167
20578454-1	2009	The present study investigated the effect of curcumin, a phenolic compound with yellow color from Curcuma longa L., on the expression of the apoptosis-related genes [BAX (Bcl-2 associated protein X), PKB, p53, MDM2 (mouse double minute 2), caspase 9, c-Ski, smad1 and smad4] in hamster opisthorchiasis.	Curcumin	45-53	caspase 9	Mus musculus	240-249
20578454-1	2009	The present study investigated the effect of curcumin, a phenolic compound with yellow color from Curcuma longa L., on the expression of the apoptosis-related genes [BAX (Bcl-2 associated protein X), PKB, p53, MDM2 (mouse double minute 2), caspase 9, c-Ski, smad1 and smad4] in hamster opisthorchiasis.	Curcumin	45-53	ski sarcoma viral oncogene homolog (avian)	Mus musculus	251-256
19958643-6	2009	When treated with 25, 50 or 100 micromol/L curcumine, the expression of MMP-2 was reduced by 21.8%+/-5.1%, 65.5%+/-9.2% or 87.9%+/-11.5% (P &lt; 0.05), and the activity of MMP-2 was also significantly reduced by curcumine.	Curcumin	212-221	matrix metallopeptidase 2	Rattus norvegicus	72-77
20079164-6	2009	RESULTS: IL-1 lowered the mRNA level and protein expression of Sox9 and collagen type II in the cultured intervertebral disc cells in a dose dependent manner (P &lt; 0.05), and this effect was attenuated by curcumin.	Curcumin	207-215	SRY-box transcription factor 9	Homo sapiens	63-67
19573523-6	2009	Curcumin was found to effectively inhibit the expression of several Wnt/beta-catenin pathway components-disheveled, beta-catenin, cyclin D1 and slug in both MCF-7 and MDA-MB-231.	Curcumin	0-8	cyclin D1	Homo sapiens	130-139
19573523-8	2009	Further, the protein levels of the positively regulated beta-catenin targets-cyclin D1 and slug, were downregulated by curcumin treatment.	Curcumin	119-127	cyclin D1	Homo sapiens	77-86
19573523-9	2009	The expression levels of two integral proteins of Wnt signaling, GSK3beta and E-cadherin were also altered by curcumin treatment.	Curcumin	110-118	glycogen synthase kinase 3 beta	Homo sapiens	65-73
19631254-4	2009	The results suggest that curcumin protects cultured rat primary prefrontal cortical neurons against Abeta-induced cytotoxicity, and both Bcl2 and caspase-3 are involved in the curcumin-induced protective effects.	Curcumin	176-184	caspase 3	Rattus norvegicus	146-155
19895312-0	2009	Effect of curcumin on lung resistance-related protein (LRP) in retinoblastoma cells.	Curcumin	10-18	major vault protein	Homo sapiens	22-53
19895312-0	2009	Effect of curcumin on lung resistance-related protein (LRP) in retinoblastoma cells.	Curcumin	10-18	major vault protein	Homo sapiens	55-58
19895312-4	2009	METHODS: In this study, curcumin mixture was used to study the modulation of LRP in Y79 retinoblastoma cell line by Western blot and RT-PCR.	Curcumin	24-32	major vault protein	Homo sapiens	77-80
19895312-6	2009	Western blot and RT-PCR analysis showed that curcumin inhibited LRP expression in a dose-dependent manner in the Y79 retinoblastoma cell line.	Curcumin	45-53	major vault protein	Homo sapiens	64-67
19895312-7	2009	CONCLUSION: These results demonstrate that curcumin modulated the expression of LRP in the Y79 retinoblastoma cell line.	Curcumin	43-51	major vault protein	Homo sapiens	80-83
19735878-9	2009	Curcumin also suppressed NF-kappaB-regulated gene products (Bcl-2, Bcl-x(L), inhibitor of apoptosis protein-2, cyclooxygenase-2, and cyclin D1).	Curcumin	0-8	cyclin D1	Homo sapiens	133-142
19655336-8	2009	Curcumin decreased COX-2 expression and inhibited phosphorylation of EGFR in SCC-1 cells.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	19-24
19702951-10	2009	The siRNA for beta-catenin suppressed the IL-1alpha-induced OPG production in both PDL cells and hGFs, whereas the AP-1 inhibitor curcumin augmented the IL-1alpha-induced OPG production in PDL cells, but not in hGFs.	Curcumin	130-138	TNF receptor superfamily member 11b	Homo sapiens	171-174
19763044-0	2009	Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway.	Curcumin	23-31	jun proto-oncogene	Mus musculus	173-178
19763044-1	2009	We investigated whether oral administration of curcumin suppressed type II collagen-induced arthritis (CIA) in mice and its effect and mechanism on matrix metalloproteinase (MMP)-1 and MMP-3 production in CIA mice, RA fibroblast-like synoviocytes (FLS), and chondrocytes.	Curcumin	47-55	matrix metallopeptidase 13	Mus musculus	148-180
19763044-6	2009	Production of MMP-1 and MMP-3 were inhibited by curcumin in CIA hind paw sections and tumor necrosis factor (TNF)-alpha-stimulated FLS and chondrocytes in a dose-dependent manner.	Curcumin	48-56	matrix metallopeptidase 13	Mus musculus	14-19
19763044-9	2009	This study suggests that the suppression of MMP-1 and MMP-3 production by curcumin in CIA is mediated through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway.	Curcumin	74-82	matrix metallopeptidase 13	Mus musculus	44-49
19763044-9	2009	This study suggests that the suppression of MMP-1 and MMP-3 production by curcumin in CIA is mediated through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway.	Curcumin	74-82	jun proto-oncogene	Mus musculus	149-154
19457704-7	2009	Furthermore, curcumin completely inhibited arecoline-induced CTGF synthesis and the inhibition is dose-dependent.	Curcumin	13-21	cellular communication network factor 2	Homo sapiens	61-65
19457704-8	2009	These results indicated that arecoline-induced CTGF synthesis was mediated by ROS, NF-kappaB, JNK, P38 MAPK pathways and curcumin could be a useful agent in controlling OSF.	Curcumin	121-129	cellular communication network factor 2	Homo sapiens	47-51
19647625-0	2009	Inhibition of p300 and nuclear factor-kappaB by curcumin and its role in diabetic nephropathy.	Curcumin	48-56	E1A binding protein p300	Homo sapiens	14-18
19501152-7	2009	In PCC4 cells, piplartine inhibited the cell cycle progression by inactivating cdk2 and destabilizing cyclin D1, whereas diferuloylmethane combination inhibited the ERK1/2 and Raf-1 signaling in addition to the inhibition of cell cycle progression.	Curcumin	121-138	mitogen-activated protein kinase 3	Mus musculus	165-171
19693275-5	2009	Inhibition of the pro-apoptotic signaling enzyme glycogen synthase kinase-3beta (GSK-3beta) blocked curcumin-induced apoptosis.	Curcumin	100-108	glycogen synthase kinase 3 beta	Homo sapiens	49-79
19693275-5	2009	Inhibition of the pro-apoptotic signaling enzyme glycogen synthase kinase-3beta (GSK-3beta) blocked curcumin-induced apoptosis.	Curcumin	100-108	glycogen synthase kinase 3 beta	Homo sapiens	81-90
19520742-10	2009	Curcumin inhibited Akt/MAPK/NF-kappaB activity and prevented nuclear translocation of the p65 NF-kappaB subunit following TNF-alpha/LPS.	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	90-93
21874542-3	2012	We found that curcumin caused lysosomal membrane permeabilization (LMP) and cytosolic relocation of cathepsin B (cath B) and cathepsin D (cath D).	Curcumin	14-22	cathepsin D	Homo sapiens	125-136
23285282-12	2012	Curcumin inhibited the RPE-choroid levels of TNF-alpha (P&lt;0.05), MCP-1 (P&lt;0.05) and ICAM-1 (P&lt;0.05), and suppressed the activation of NF-kappaB in nuclear extracts (P&lt;0.05) and the activation of HIF-1alpha (P&lt;0.05).	Curcumin	0-8	intercellular adhesion molecule 1	Mus musculus	90-96
23251674-11	2012	The inhibited phosphorylation of Akt and GSK-3beta was also restored by curcumin treatment.	Curcumin	72-80	glycogen synthase kinase 3 beta	Rattus norvegicus	41-50
22675553-6	2012	Pretreatment of osteoblasts with PI3K inhibitor (Ly294002), Akt inhibitor, c-Src inhibitor (PP2), or AP-1 inhibitor (curcumin) blocked the potentiating action of HGF.	Curcumin	117-125	hepatocyte growth factor	Homo sapiens	162-165
21922289-0	2011	Vascular anti-inflammatory effects of curcumin on HMGB1-mediated responses in vitro.	Curcumin	38-46	high mobility group box 1	Homo sapiens	50-55
21922289-4	2011	However, the effects of curcumin on HMGB1-mediated proinflammatory responses have not been studied.	Curcumin	24-32	high mobility group box 1	Homo sapiens	36-41
21922289-5	2011	METHODS: The anti-inflammatory activities of curcumin were determined by measuring solute flux, leukocyte adhesion and migration and activation of proinflammatory proteins in HMGB1-activated human umbilical vein endothelial cells.	Curcumin	45-53	high mobility group box 1	Homo sapiens	175-180
21922289-6	2011	RESULTS: Curcumin inhibited the release of HMGB1 by lipopolysaccharide (LPS)- and HMGB1-mediated barrier disruption, neutrophil adhesion and migration, and expression of cell adhesion molecules.	Curcumin	9-17	high mobility group box 1	Homo sapiens	43-48
21922289-6	2011	RESULTS: Curcumin inhibited the release of HMGB1 by lipopolysaccharide (LPS)- and HMGB1-mediated barrier disruption, neutrophil adhesion and migration, and expression of cell adhesion molecules.	Curcumin	9-17	high mobility group box 1	Homo sapiens	82-87
21922289-7	2011	Further studies revealed that curcumin down-regulated the cell surface receptor of HMGB1 in human endothelial cells.	Curcumin	30-38	high mobility group box 1	Homo sapiens	83-88
21922289-8	2011	CONCLUSION: These findings suggest that curcumin exerts anti-inflammatory effects in HMGB1-mediated proinflammatory responses, endorsing its usefulness as therapy for vascular inflammatory diseases.	Curcumin	40-48	high mobility group box 1	Homo sapiens	85-90
21748336-0	2011	Curcumin promotes cholesterol efflux from adipocytes related to PPARgamma-LXRalpha-ABCA1 passway.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Oryctolagus cuniculus	64-73
21748336-5	2011	The increased expression of PPARgamma, LXRalpha and ABCA1 caused by curcumin were parallel.	Curcumin	68-76	peroxisome proliferator-activated receptor gamma	Oryctolagus cuniculus	28-37
21748336-6	2011	When the adipocytes were pre-treated by GW9662, the increased expression of PPARgamma induced by curcumin was partially prevented, subsequent to the down-regulation of LXRalpha and ABCA1.	Curcumin	97-105	peroxisome proliferator-activated receptor gamma	Oryctolagus cuniculus	76-85
21748336-7	2011	Curcumin can affect the cholesterol efflux from adipocytes by regulating the PPARgamma-LXR-ABCA1 passway.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Oryctolagus cuniculus	77-86
21998146-7	2011	Inhibition of AP-1 activity by curcumin attenuated the S1P-induced FN expression.	Curcumin	31-39	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-18
22058071-5	2011	Aortic arch sections revealed curcumin ameliorated early atherosclerotic lesions, lipid infiltration, ICAM-1 and VCAM-1 localization, similar to lovastatin treatment.	Curcumin	30-38	intercellular adhesion molecule 1	Mus musculus	102-108
22058071-9	2011	Hepatic complement factor D (Cfd) and systemic CRP levels, markers of immune complement pathway activation, were significantly reduced by curcumin treatment.	Curcumin	138-146	complement factor D (adipsin)	Mus musculus	8-27
30634242-5	2011	Furthermore, curcumin could block H2O2-mediated degradation of the protein IkappaBalpha and subsequent activation of nuclear factor kappaB, thus inhibiting the expression of its target gene cyclooxygenase 2.	Curcumin	13-21	prostaglandin-endoperoxide synthase 2	Mus musculus	190-206
21821729-6	2011	Curcumin dose dependently accelerated e19 fibroblast differentiation [increased parathyroid hormone-related protein (PTHrP) receptor, PPARgamma, and adipocyte differentiation-related protein (ADRP) levels and triolein uptake] and proliferation (increased thymidine incorporation).	Curcumin	0-8	perilipin 2	Rattus norvegicus	149-190
21821729-6	2011	Curcumin dose dependently accelerated e19 fibroblast differentiation [increased parathyroid hormone-related protein (PTHrP) receptor, PPARgamma, and adipocyte differentiation-related protein (ADRP) levels and triolein uptake] and proliferation (increased thymidine incorporation).	Curcumin	0-8	perilipin 2	Rattus norvegicus	192-196
21821729-7	2011	Pretreatment with curcumin blocked the hyperoxia-induced decrease (PPARgamma and ADRP) and increase (alpha-smooth muscle actin and fibronectin) in markers of lung injury/repair, as well as the activation of TGF-beta signaling.	Curcumin	18-26	perilipin 2	Rattus norvegicus	81-85
22199113-10	2011	Curcumin treatment inhibited the elevation of NF-kappaB-p65 in the nucleus of mouse pancreas AP group and RAW264.7 cells, but significantly increased the expression of PPARgamma.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	168-177
21732406-5	2011	Curcumin suppressed OC formation by increasing receptor activator of nuclear factor-kappaB ligand (RANKL)-induced glutathione peroxidase-1, and reversed the stimulatory effect of homocysteine, a known H(2) O(2) generator, on OC formation by restoring Gpx activity.	Curcumin	0-8	peroxiredoxin 6 pseudogene 2	Mus musculus	251-254
22045654-1	2011	SCOPE: We hypothesized that curcumin, a potent anti-oxidant, might be beneficial in ameliorating the development of diabetic nephropathy through inhibition of PKC-alpha and PKC-beta1 activity-ERK1/2 pathway.	Curcumin	28-36	mitogen activated protein kinase 3	Rattus norvegicus	192-198
22045654-6	2011	Furthermore, the high-glucose-induced PKC-alpha and PKC-beta1 activities and phosphorylated ERK1/2 was significantly diminished by curcumin.	Curcumin	131-139	mitogen activated protein kinase 3	Rattus norvegicus	92-98
22045654-7	2011	Curcumin also attenuated the expression of TGF-beta1, CTGF, osteopontin, p300 and ECM proteins such as fibronectin and type IV collagen.	Curcumin	0-8	secreted phosphoprotein 1	Rattus norvegicus	60-71
22045655-0	2011	Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1.	Curcumin	29-37	ubiquitin-like, containing PHD and RING finger domains, 1	Mus musculus	129-134
22045655-8	2011	In contrast, expressions of PDE1A, cyclin A and the epigenetic integrator ubiquitin-like containing PHD and Ring Finger domains 1 (UHRF1) and DNA methyltransferase 1 (DNMT1) were decreased by curcumin.	Curcumin	192-200	ubiquitin-like, containing PHD and RING finger domains, 1	Mus musculus	131-136
22045655-11	2011	CONCLUSION: Curcumin exerts its anti-cancer property by targeting PDE1 that inhibits melanoma cell proliferation via UHRF1, DNMT1, cyclin A, p21 and p27 regulations.	Curcumin	12-20	ubiquitin-like, containing PHD and RING finger domains, 1	Mus musculus	117-122
22045655-11	2011	CONCLUSION: Curcumin exerts its anti-cancer property by targeting PDE1 that inhibits melanoma cell proliferation via UHRF1, DNMT1, cyclin A, p21 and p27 regulations.	Curcumin	12-20	cyclin A2	Mus musculus	131-139
22357515-7	2011	When suppressing AP-1 activity, the cyclin D1 and CDK4 expression levels decreased and the E2F-4 expression level increased in curcumin plus silica group, as compared with silica group.	Curcumin	127-135	cyclin D1	Homo sapiens	36-45
22357515-7	2011	When suppressing AP-1 activity, the cyclin D1 and CDK4 expression levels decreased and the E2F-4 expression level increased in curcumin plus silica group, as compared with silica group.	Curcumin	127-135	cyclin dependent kinase 4	Homo sapiens	50-54
22357515-7	2011	When suppressing AP-1 activity, the cyclin D1 and CDK4 expression levels decreased and the E2F-4 expression level increased in curcumin plus silica group, as compared with silica group.	Curcumin	127-135	E2F transcription factor 4	Homo sapiens	91-96
21855605-0	2011	Curcumin ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) activates and desensitizes the nociceptor ion channel TRPA1.	Curcumin	0-8	transient receptor potential cation channel subfamily A member 1	Homo sapiens	131-136
21855605-0	2011	Curcumin ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) activates and desensitizes the nociceptor ion channel TRPA1.	Curcumin	10-75	transient receptor potential cation channel subfamily A member 1	Homo sapiens	131-136
21855605-4	2011	In order to test the hypothesis that the electrophilic curcumin activates TRPA1, we have performed whole-cell, voltage-clamp analysis on both HEK293 cells expressing human TRPA1 (hTRPA1-HEK) and native mouse vagal neurons.	Curcumin	55-63	transient receptor potential cation channel subfamily A member 1	Homo sapiens	74-79
21855605-5	2011	In nominally calcium-free extracellular and intracellular solutions which minimized the chances of calcium-dependent activation of TRPA1, curcumin increased TRPA1 currents in hTRPA1-HEK cells in a concentration-dependent manner (1-30muM) but did not cause block or activation of recombinant TRPM8 and TRPV1.	Curcumin	138-146	transient receptor potential cation channel subfamily A member 1	Homo sapiens	131-136
21855605-5	2011	In nominally calcium-free extracellular and intracellular solutions which minimized the chances of calcium-dependent activation of TRPA1, curcumin increased TRPA1 currents in hTRPA1-HEK cells in a concentration-dependent manner (1-30muM) but did not cause block or activation of recombinant TRPM8 and TRPV1.	Curcumin	138-146	transient receptor potential cation channel subfamily A member 1	Homo sapiens	157-162
21855605-5	2011	In nominally calcium-free extracellular and intracellular solutions which minimized the chances of calcium-dependent activation of TRPA1, curcumin increased TRPA1 currents in hTRPA1-HEK cells in a concentration-dependent manner (1-30muM) but did not cause block or activation of recombinant TRPM8 and TRPV1.	Curcumin	138-146	transient receptor potential cation channel subfamily A member 1	Homo sapiens	175-181
21855605-5	2011	In nominally calcium-free extracellular and intracellular solutions which minimized the chances of calcium-dependent activation of TRPA1, curcumin increased TRPA1 currents in hTRPA1-HEK cells in a concentration-dependent manner (1-30muM) but did not cause block or activation of recombinant TRPM8 and TRPV1.	Curcumin	138-146	transient receptor potential cation channel subfamily M member 8	Homo sapiens	291-296
21855605-5	2011	In nominally calcium-free extracellular and intracellular solutions which minimized the chances of calcium-dependent activation of TRPA1, curcumin increased TRPA1 currents in hTRPA1-HEK cells in a concentration-dependent manner (1-30muM) but did not cause block or activation of recombinant TRPM8 and TRPV1.	Curcumin	138-146	transient receptor potential cation channel subfamily V member 1	Homo sapiens	301-306
21855605-8	2011	With physiological levels of calcium added to the external solution to facilitate channel desensitization, curcumin-dependent currents in hTRPA1-HEK cells were completely desensitized and exhibited marked tachyphylaxis upon subsequent application of curcumin.	Curcumin	107-115	transient receptor potential cation channel subfamily A member 1	Homo sapiens	138-144
21855605-8	2011	With physiological levels of calcium added to the external solution to facilitate channel desensitization, curcumin-dependent currents in hTRPA1-HEK cells were completely desensitized and exhibited marked tachyphylaxis upon subsequent application of curcumin.	Curcumin	250-258	transient receptor potential cation channel subfamily A member 1	Homo sapiens	138-144
21855605-9	2011	Taken together, these results demonstrate that curcumin causes activation and subsequent desensitization of native and recombinant TRPA1 ion channels of multiple mammalian species.	Curcumin	47-55	transient receptor potential cation channel subfamily A member 1	Homo sapiens	131-136
21896275-8	2011	p300/CBP-specific inhibitor curcumin can reverse the induction of p16(INK4a) by p33(ING1b).	Curcumin	28-36	E1A binding protein p300	Homo sapiens	0-4
21836020-7	2011	In this article, we define for the first time, that curcumin directly induces a tumor-suppressive miRNA, miR-203, in bladder cancer.	Curcumin	52-60	microRNA 203a	Homo sapiens	105-112
21836020-11	2011	Curcumin induces hypomethylation of the miR-203 promoter and subsequent upregulation of miR-203 expression.	Curcumin	0-8	microRNA 203a	Homo sapiens	40-47
21836020-11	2011	Curcumin induces hypomethylation of the miR-203 promoter and subsequent upregulation of miR-203 expression.	Curcumin	0-8	microRNA 203a	Homo sapiens	88-95
21484797-0	2011	[DLys(6)]-luteinizing hormone releasing hormone-curcumin conjugate inhibits pancreatic cancer cell growth in vitro and in vivo.	Curcumin	48-56	gonadotropin releasing hormone 1	Homo sapiens	10-47
21484797-5	2011	[DLys(6)]-LHRH-curcumin inhibited cell proliferation of pancreatic cancer cell lines and induced apoptotic cell death (p &lt; 0.05).	Curcumin	15-23	gonadotropin releasing hormone 1	Homo sapiens	10-14
21484797-7	2011	The activity of [DLys(6)]-LHRH-curcumin was equal to free curcumin at equimolar concentrations in vitro.	Curcumin	31-39	gonadotropin releasing hormone 1	Homo sapiens	26-30
21484797-8	2011	Unlike curcumin itself, the [DLys(6)]-LHRH-curcumin conjugate is water soluble which allows its intravenous administration.	Curcumin	7-15	gonadotropin releasing hormone 1	Homo sapiens	38-42
21484797-8	2011	Unlike curcumin itself, the [DLys(6)]-LHRH-curcumin conjugate is water soluble which allows its intravenous administration.	Curcumin	43-51	gonadotropin releasing hormone 1	Homo sapiens	38-42
21484797-10	2011	[DLys(6)]-LHRH-curcumin treatment enhanced apoptosis compared to [DLys(6)]-LHRH and vehicle-treated controls in tumor tissue.	Curcumin	15-23	gonadotropin releasing hormone 1	Homo sapiens	10-14
21750867-6	2011	Curcumin enhanced manganese superoxide dismutase (MnSOD) protein expression in the MCF-10F and Alpha3 cell lines.	Curcumin	0-8	superoxide dismutase 2	Homo sapiens	18-48
21750867-6	2011	Curcumin enhanced manganese superoxide dismutase (MnSOD) protein expression in the MCF-10F and Alpha3 cell lines.	Curcumin	0-8	superoxide dismutase 2	Homo sapiens	50-55
21116627-0	2011	Modulatory effects of curcumin on multi-drug resistance-associated protein 5 in pancreatic cancer cells.	Curcumin	22-30	ATP binding cassette subfamily C member 5	Homo sapiens	34-76
21116627-3	2011	Our aim was to evaluate whether curcumin could reverse this multi-drug resistance by inhibition of MRP5-mediated efflux.	Curcumin	32-40	ATP binding cassette subfamily C member 5	Homo sapiens	99-103
21116627-6	2011	RESULTS: The cellular accumulation of BCECF in HEK293/MRP5 cells and in PANC-1 and MiaPaCa-2 cells was significantly increased by curcumin in a concentration-dependent manner.	Curcumin	130-138	ATP binding cassette subfamily C member 5	Homo sapiens	54-58
21116627-8	2011	In the proliferation assays, curcumin caused a concentration-dependant increase in the sensitivity to the cytotoxic drug 5-fluorouracil in HEK293/MRP5 cells, PANC-1 and MiaPaCa-2 pancreatic cancer cells, but not in parental HEK293 cells.	Curcumin	29-37	ATP binding cassette subfamily C member 5	Homo sapiens	146-150
21116627-9	2011	CONCLUSIONS: Our results suggest that curcumin is an inhibitor of MRP5 and may be useful in the reversal of multi-drug resistance in pancreatic cancer chemotherapy.	Curcumin	38-46	ATP binding cassette subfamily C member 5	Homo sapiens	66-70
21519785-6	2011	In addition, curcumin significantly inactivated p38 mitogen-activated protein kinases (MAPK) and stress-activated protein kinase/c-Jun N-terminal kinases (SARK/JNK), coupled with inhibition of p53 and p21 tumor suppressor gene products.	Curcumin	13-21	mitogen-activated protein kinase 14	Mus musculus	48-51
22362715-7	2011	Curcumin down-regulated the expression of cluster of differntiation (CD)147, matrix metalloproteinase 2, and matrix metalloproteinase 9 and inhibited the phosphorylation of epidermal growth factor receptor (EGFR), the phosphoinositilde 3-kinase (PI3K)/protein kinase B (Akt), p38 mitogen-activated protein kinase (MAPK), and p44/42MAPK in Hca-F cells.	Curcumin	0-8	matrix metallopeptidase 9	Mus musculus	109-135
22362715-7	2011	Curcumin down-regulated the expression of cluster of differntiation (CD)147, matrix metalloproteinase 2, and matrix metalloproteinase 9 and inhibited the phosphorylation of epidermal growth factor receptor (EGFR), the phosphoinositilde 3-kinase (PI3K)/protein kinase B (Akt), p38 mitogen-activated protein kinase (MAPK), and p44/42MAPK in Hca-F cells.	Curcumin	0-8	mitogen-activated protein kinase 3	Mus musculus	314-318
22362715-7	2011	Curcumin down-regulated the expression of cluster of differntiation (CD)147, matrix metalloproteinase 2, and matrix metalloproteinase 9 and inhibited the phosphorylation of epidermal growth factor receptor (EGFR), the phosphoinositilde 3-kinase (PI3K)/protein kinase B (Akt), p38 mitogen-activated protein kinase (MAPK), and p44/42MAPK in Hca-F cells.	Curcumin	0-8	mitogen-activated protein kinase 3	Mus musculus	325-328
22362715-7	2011	Curcumin down-regulated the expression of cluster of differntiation (CD)147, matrix metalloproteinase 2, and matrix metalloproteinase 9 and inhibited the phosphorylation of epidermal growth factor receptor (EGFR), the phosphoinositilde 3-kinase (PI3K)/protein kinase B (Akt), p38 mitogen-activated protein kinase (MAPK), and p44/42MAPK in Hca-F cells.	Curcumin	0-8	mitogen-activated protein kinase 3	Mus musculus	331-335
21702507-1	2011	A series of 3,5-bis(arylidene)-4-piperidone (DAP) compounds are considered as synthetic analogues of curcumin for anticancer properties.	Curcumin	101-109	death associated protein	Homo sapiens	45-48
21774804-9	2011	The residual tumors from APCMin +/- mice treated with dasatinib and/or curcumin showed 80-90% decrease in the expression of the CSC markers ALDH, CD44, CD133, CD166.	Curcumin	71-79	activated leukocyte cell adhesion molecule	Mus musculus	159-164
21547911-10	2011	Hepatic glutathione-s-transferase and cyclooxygenase-2 activities, biomarkers for chemoprevention, were altered following treatment with curcumin microparticles.	Curcumin	137-145	prostaglandin-endoperoxide synthase 2	Mus musculus	38-54
21598989-8	2011	Further, we found that quercetin and curcumin induced growth arrest by inhibition of Skp2, and induced p27 expression in MDA-MB-231 cells.	Curcumin	37-45	S-phase kinase associated protein 2	Homo sapiens	85-89
21729550-7	2011	And RT-PCR showed, as compared with curcumin or bortezomib group, there was mRNA expression decrease of BCL-2, cyclin D1 but increase of BAX in combined group.	Curcumin	36-44	cyclin D1	Homo sapiens	111-120
21589925-9	2011	Inhibitors for MEK1/2 (PD98059), JNK (SP600125) or AP1 (curcumin) significantly inhibited MCP-1-induced amylin mRNA expression.	Curcumin	56-64	jun proto-oncogene	Mus musculus	51-54
20655188-11	2011	Curcumin treatment also significantly reduced HAT activity, level of p300 and acetylated CBP/p300 gene expression, and induced HDAC2 expression by curcumin.	Curcumin	0-8	E1A binding protein p300	Homo sapiens	69-73
21237271-8	2011	We further found that curcumin can reduce mutant alpha- synuclein-induced intracellular reactive oxygen species (ROS) levels, mitochondrial depolarization, cytochrome c release, and caspase-9 and caspase-3 activation.	Curcumin	22-30	caspase 3	Rattus norvegicus	196-205
20969478-8	2011	Antioxidants such as ethyl pyruvate, quercetin, green tea, N-acetylcysteine, and curcumin are protective in the setting of experimental infection/sepsis and injury including ischemia-reperfusion, partly through attenuating HMGB1 release and systemic accumulation.	Curcumin	81-89	high mobility group box 1	Homo sapiens	223-228
19263217-5	2009	The real time PCR analysis showed that 20 microM of curcumin for 48 h treatment decreased ATM, ATR, BRCA1, 14-3-3sigma, DNA-PK and MGMT mRNA, and ATM and MGMT mRNA expression were inhibited in a time-dependent manner.	Curcumin	52-60	ATR serine/threonine kinase	Rattus norvegicus	95-98
19263217-5	2009	The real time PCR analysis showed that 20 microM of curcumin for 48 h treatment decreased ATM, ATR, BRCA1, 14-3-3sigma, DNA-PK and MGMT mRNA, and ATM and MGMT mRNA expression were inhibited in a time-dependent manner.	Curcumin	52-60	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	131-135
19263217-5	2009	The real time PCR analysis showed that 20 microM of curcumin for 48 h treatment decreased ATM, ATR, BRCA1, 14-3-3sigma, DNA-PK and MGMT mRNA, and ATM and MGMT mRNA expression were inhibited in a time-dependent manner.	Curcumin	52-60	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	154-158
19448398-0	2009	Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expression.	Curcumin	0-8	p21 (RAC1) activated kinase 1	Homo sapiens	98-102
19448398-0	2009	Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expression.	Curcumin	0-8	cyclin D1	Homo sapiens	116-125
19448398-2	2009	It has been previously demonstrated that curcumin is a potent inhibitor of EGF-receptor (EGFR) tyrosine kinase, but its inhibitive effect on p21-activated kinase 1 (PAK1), a downstream protein of EGFR, has not been defined.	Curcumin	41-49	p21 (RAC1) activated kinase 1	Homo sapiens	141-163
19448398-2	2009	It has been previously demonstrated that curcumin is a potent inhibitor of EGF-receptor (EGFR) tyrosine kinase, but its inhibitive effect on p21-activated kinase 1 (PAK1), a downstream protein of EGFR, has not been defined.	Curcumin	41-49	p21 (RAC1) activated kinase 1	Homo sapiens	165-169
19448398-3	2009	In this paper we found that curcumin repressed the expression of HER2 and inhibited the kinase activity of PAK1 without affecting its expression.	Curcumin	28-36	p21 (RAC1) activated kinase 1	Homo sapiens	107-111
19448398-6	2009	Curcumin also downregulated the mRNA and the protein expression of cyclin D1 and suppressed transition of the cells from G(1) to S phase.	Curcumin	0-8	cyclin D1	Homo sapiens	67-76
19359525-12	2009	Collectively, we suggest that trans-resveratrol and curcumin act as antagonists/inverse agonists at CB1 receptors at dietary relevant concentrations.	Curcumin	52-60	cannabinoid receptor 1 (brain)	Mus musculus	100-103
19344704-4	2009	Whereas the expression of glutathione peroxidase (GPx), catalase, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and heme oxygenase-1 (HO-1) increased with curcumin concentration and also with increase in time of incubation, the expression of Mn- superoxide dismutase (Mn-SOD) showed concentration dependant repression upon treatment with curcumin.	Curcumin	148-156	superoxide dismutase 2	Homo sapiens	235-259
19344704-4	2009	Whereas the expression of glutathione peroxidase (GPx), catalase, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and heme oxygenase-1 (HO-1) increased with curcumin concentration and also with increase in time of incubation, the expression of Mn- superoxide dismutase (Mn-SOD) showed concentration dependant repression upon treatment with curcumin.	Curcumin	148-156	superoxide dismutase 2	Homo sapiens	261-267
22291761-4	2011	The aim of this study was to investigate whether SMN2 expression can be increased by caffeic acid, chlorogenic acid and curcumin, which are designed by modifications of the carboxylic acid class of histone deacetylase (HDAC) inhibitors.	Curcumin	120-128	survival of motor neuron 2, centromeric	Homo sapiens	49-53
25031810-11	2014	High concentration of Curcumin was able to reduce the chronic neuropathic pain induced by CCI model and the serum level of COX-2.	Curcumin	22-30	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	123-128
24983737-9	2014	However, when telomerase was inhibited by TERT siRNA, the neuroprotection by curcumin and Cur1 were ceased.	Curcumin	77-85	telomerase reverse transcriptase	Cricetulus griseus	42-46
21577278-7	2011	Moreover, curcumin accelerated spontaneous apoptosis of neutrophils, as indicated by increased externalisation of phosphatidylserine, by intercalation of propidium iodide and by enhanced activity of the executioner caspase-3.	Curcumin	10-18	caspase 3	Rattus norvegicus	215-224
21347286-7	2011	Curcumin increased the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) mRNA, but protein levels were lower.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	37-53
21347286-7	2011	Curcumin increased the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) mRNA, but protein levels were lower.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	55-60
21347286-9	2011	CUGBP2 binding to COX-2 and VEGF mRNA was also enhanced, thereby increasing mRNA stability, the half-life changing from 30 min to 8 h. On the other hand, silencer-mediated knockdown of CUGBP2 partially restored the expression of COX-2 and VEGF even with curcumin treatment.	Curcumin	254-262	prostaglandin-endoperoxide synthase 2	Mus musculus	18-23
21347286-11	2011	CONCLUSION/SIGNIFICANCE: Curcumin inhibits pancreatic tumor growth through mitotic catastrophe by increasing the expression of RNA binding protein CUGBP2, thereby inhibiting the translation of COX-2 and VEGF mRNA.	Curcumin	25-33	prostaglandin-endoperoxide synthase 2	Mus musculus	193-198
18720192-1	2009	Curcumin was investigated as an inhibitor of glycogen synthase kinase-3beta (GSK-3beta) in an attempt to explain some of its interesting multiple pharmacological effects, such as its anti-diabetic, anti-inflammatory, anti-cancer, anti-malarial and anti-alzheimer"s properties.	Curcumin	0-8	glycogen synthase kinase 3 alpha	Mus musculus	77-86
18720192-2	2009	The investigation included simulated docking experiments to fit curcumin within the binding pocket of GSK-3beta followed by experimental in vitro and in vivo validations.	Curcumin	64-72	glycogen synthase kinase 3 alpha	Mus musculus	102-111
18720192-3	2009	Curcumin was found to optimally fit within the binding pocket of GSK-3beta via several attractive interactions with key amino acids.	Curcumin	0-8	glycogen synthase kinase 3 alpha	Mus musculus	65-74
18720192-4	2009	Experimentally, curcumin was found to potently inhibit GSK-3beta (IC50 = 66.3 nM).	Curcumin	16-24	glycogen synthase kinase 3 alpha	Mus musculus	55-64
18720192-6	2009	Our findings strongly suggest that the diverse pharmacological activities of curcumin are at least partially mediated by inhibition of GSK-3beta.	Curcumin	77-85	glycogen synthase kinase 3 alpha	Mus musculus	135-144
24945581-0	2014	A PPARgamma, NF-kappaB and AMPK-dependent mechanism may be involved in the beneficial effects of curcumin in the diabetic db/db mice liver.	Curcumin	97-105	peroxisome proliferator activated receptor gamma	Mus musculus	2-11
21071447-0	2011	Autoxidative and cyclooxygenase-2 catalyzed transformation of the dietary chemopreventive agent curcumin.	Curcumin	96-104	prostaglandin-endoperoxide synthase 2	Mus musculus	17-33
24945581-5	2014	Curcumin increased the expression of AMPK and PPARgamma, and diminished NF-kappaB protein in db/db mice.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	46-55
20950605-0	2011	Downregulation of B lymphocyte stimulator expression by curcumin in B lymphocyte via suppressing nuclear translocation of NF-kappaB.	Curcumin	56-64	TNF superfamily member 13b	Homo sapiens	18-41
24945581-8	2014	In conclusion, curcumin regulates the expression of AMPK, PPARgamma, and NF-kappaB; suggesting a beneficial effect for treatment of T2DM complications.	Curcumin	15-23	peroxisome proliferator activated receptor gamma	Mus musculus	58-67
20950605-4	2011	In this study, we report that curcumin inhibits the expression of BLyS and that a DNA-binding site for the transcriptional factor NF-kappaB in the BLyS promoter region is required for this regulation.	Curcumin	30-38	TNF superfamily member 13b	Homo sapiens	66-70
20950605-4	2011	In this study, we report that curcumin inhibits the expression of BLyS and that a DNA-binding site for the transcriptional factor NF-kappaB in the BLyS promoter region is required for this regulation.	Curcumin	30-38	TNF superfamily member 13b	Homo sapiens	147-151
20950605-5	2011	Moreover, we find that curcumin reduces the DNA-binding activity of NF-kappaB to the BLyS promoter region and suppresses nuclear translocation of p65, suggesting that curcumin may suppress BLyS expression via negatively interfering with NF-kappaB signaling.	Curcumin	23-31	TNF superfamily member 13b	Homo sapiens	85-89
19304795-0	2009	Modulation of ovarian structure and abdominal obesity in curcumin- and flutamide-treated aging FSH-R haploinsufficient mice.	Curcumin	57-65	follicle stimulating hormone receptor	Mus musculus	95-100
20950605-5	2011	Moreover, we find that curcumin reduces the DNA-binding activity of NF-kappaB to the BLyS promoter region and suppresses nuclear translocation of p65, suggesting that curcumin may suppress BLyS expression via negatively interfering with NF-kappaB signaling.	Curcumin	23-31	RELA proto-oncogene, NF-kB subunit	Homo sapiens	146-149
24440669-8	2014	Thermal studies (TGA) and surface chemistry studies (FT-IR, XRD) showed the existence of drug curcumin in C-PSA-NPs.	Curcumin	94-102	T-box transcription factor 1	Homo sapiens	17-20
20950605-5	2011	Moreover, we find that curcumin reduces the DNA-binding activity of NF-kappaB to the BLyS promoter region and suppresses nuclear translocation of p65, suggesting that curcumin may suppress BLyS expression via negatively interfering with NF-kappaB signaling.	Curcumin	23-31	TNF superfamily member 13b	Homo sapiens	189-193
20950605-5	2011	Moreover, we find that curcumin reduces the DNA-binding activity of NF-kappaB to the BLyS promoter region and suppresses nuclear translocation of p65, suggesting that curcumin may suppress BLyS expression via negatively interfering with NF-kappaB signaling.	Curcumin	167-175	TNF superfamily member 13b	Homo sapiens	85-89
20950605-5	2011	Moreover, we find that curcumin reduces the DNA-binding activity of NF-kappaB to the BLyS promoter region and suppresses nuclear translocation of p65, suggesting that curcumin may suppress BLyS expression via negatively interfering with NF-kappaB signaling.	Curcumin	167-175	RELA proto-oncogene, NF-kB subunit	Homo sapiens	146-149
20950605-5	2011	Moreover, we find that curcumin reduces the DNA-binding activity of NF-kappaB to the BLyS promoter region and suppresses nuclear translocation of p65, suggesting that curcumin may suppress BLyS expression via negatively interfering with NF-kappaB signaling.	Curcumin	167-175	TNF superfamily member 13b	Homo sapiens	189-193
20950605-6	2011	These results suggest that curcumin may serve as a novel therapeutic agent in the treatment of autoimmune diseases by targeting BLyS.	Curcumin	27-35	TNF superfamily member 13b	Homo sapiens	128-132
20959361-6	2011	The ability of ACC cells to migrate/invade and induce angiogenesis was also significantly attenuated by curcumin, accompanied by the down-regulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 and -9.	Curcumin	104-112	matrix metallopeptidase 2	Homo sapiens	198-231
19594013-1	2009	OBJECTIVE: To observe the effect of different dosage of curcumin on expression of MMP-2 and MMP-9 in the tissue of cystiform in air-pouch mouse models after the injection of polyethylene wear particles, and to investigate its mechanism of intervening inflammatory response induced by wear particles.	Curcumin	56-64	matrix metallopeptidase 9	Mus musculus	92-97
19594013-13	2009	There was significant difference bewteen group B and group C in MMP-9 expression at 7 and 14 days after curcumin delivery (P &lt; 0.05).	Curcumin	104-112	matrix metallopeptidase 9	Mus musculus	64-69
19594013-16	2009	Curcumin can restrain expression of MMP-2 and MMP-9 in cystiform tissue of air-pouch animal models, and expression of MMP-2 and MMP-9 may be regulated by the activation of NF-kappaB.	Curcumin	0-8	matrix metallopeptidase 9	Mus musculus	46-51
19297423-5	2009	Supplementing the high-fat diet of mice with curcumin did not affect food intake but reduced body weight gain, adiposity, and microvessel density in adipose tissue, which coincided with reduced expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2.	Curcumin	45-53	kinase insert domain protein receptor	Mus musculus	267-274
19297423-8	2009	In addition, curcumin significantly lowered serum cholesterol and expression of PPARgamma and CCAAT/enhancer binding protein alpha, 2 key transcription factors in adipogenesis and lipogenesis.	Curcumin	13-21	peroxisome proliferator activated receptor gamma	Mus musculus	80-89
19297423-8	2009	In addition, curcumin significantly lowered serum cholesterol and expression of PPARgamma and CCAAT/enhancer binding protein alpha, 2 key transcription factors in adipogenesis and lipogenesis.	Curcumin	13-21	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	94-130
19393026-9	2009	Inhibition of AP-1 with curcumin also inhibited 14-3-3gamma up-regulation indicating that ischemia-induced up-regulation of 14-3-3gamma in astrocyte involves activation of the JNK/p-c-Jun/AP-1 pathway.	Curcumin	24-32	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Homo sapiens	48-59
19393026-9	2009	Inhibition of AP-1 with curcumin also inhibited 14-3-3gamma up-regulation indicating that ischemia-induced up-regulation of 14-3-3gamma in astrocyte involves activation of the JNK/p-c-Jun/AP-1 pathway.	Curcumin	24-32	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Homo sapiens	124-135
19771848-0	2009	[Study on effects of curcumin on expressions of PDGF-BB, PDGFRbeta and ERK1 of HSC].	Curcumin	21-29	mitogen activated protein kinase 3	Rattus norvegicus	71-75
19771848-1	2009	OBJECTIVE: To observe the effects of curcumin on expression of PDGF-BB, PDGFRbeta and ERK1 of rat Hepatic stellate cell (HSC-T6).	Curcumin	37-45	mitogen activated protein kinase 3	Rattus norvegicus	86-90
19771848-4	2009	The protein levels of PDGF-BB, PDGFRbeta and ERK1 was detected by immunhistochemical examination; The influence of curcumin on expression of PDGF-BB, PDGFRbeta and ERK1 mRNA was detected by RT-PCR.	Curcumin	115-123	mitogen activated protein kinase 3	Rattus norvegicus	164-168
19771848-6	2009	After the intervention of different concentration of curcumin,the masculine degrees of PDGF-BB, PDGFRbeta and ERK1 and the masculine cell population decreased obviously.	Curcumin	53-61	mitogen activated protein kinase 3	Rattus norvegicus	110-114
19771848-8	2009	After the intervention of different concentration of curcumin, the expression of PDGF-BB, PDGFRbeta and ERK1 mRNA decreased in a dose-dependent manner.	Curcumin	53-61	mitogen activated protein kinase 3	Rattus norvegicus	104-108
19771848-9	2009	CONCLUSION: Curcumin could inhibit the expression of PDGF-BB, PDGFRbeta and ERK1 which might be the mechanism of action curcumin on anti-fibrosis.	Curcumin	12-20	mitogen activated protein kinase 3	Rattus norvegicus	76-80
19771848-9	2009	CONCLUSION: Curcumin could inhibit the expression of PDGF-BB, PDGFRbeta and ERK1 which might be the mechanism of action curcumin on anti-fibrosis.	Curcumin	120-128	mitogen activated protein kinase 3	Rattus norvegicus	76-80
19302828-7	2009	Moreover, curcumin enhanced AC activity and cAMP levels in platelet and various brain regions, and up-regulated mRNA expressions of AC subtypes AC 2, AC 8 and cAMP response element binding protein (CREB) in the hippocampus, cortex and hypothalamus of the CUMS rats.	Curcumin	10-18	adenylate cyclase 8	Rattus norvegicus	150-154
19429032-6	2009	Curcumin attenuated ethanol-induced cell death, inhibited activation of p38 MAPK, and activated MKP-1.	Curcumin	0-8	mitogen-activated protein kinase 14	Mus musculus	72-80
19429032-8	2009	Our results suggest that curcumin can attenuate ethanol-induced neurotoxicity by activating MKP-1 which acts as the negative regulator of p38 MAPK.	Curcumin	25-33	mitogen-activated protein kinase 14	Mus musculus	138-146
19161989-6	2009	With increasing doses of curcumin, the Tyr(131) residue of PKCdelta, which is known to direct its degradation, became progressively phosphorylated and this was associated with numerous Tyr(131)-phospho-PKCdelta fragments.	Curcumin	25-33	protein kinase C, delta	Rattus norvegicus	59-67
19161989-6	2009	With increasing doses of curcumin, the Tyr(131) residue of PKCdelta, which is known to direct its degradation, became progressively phosphorylated and this was associated with numerous Tyr(131)-phospho-PKCdelta fragments.	Curcumin	25-33	protein kinase C, delta	Rattus norvegicus	202-210
19350453-2	2009	Curcumin, a promising chemotherapeutic agent, inhibits human GSTA1-1, GSTM1-1, and GSTP1-1 isoenzymes.	Curcumin	0-8	glutathione S-transferase alpha 1	Homo sapiens	61-68
19350453-4	2009	Most of the 34 curcumin analogues showed less potent inhibitory activities towards GSTA1-1, GSTM1-1, and GSTP1-1 than the parent curcumin.	Curcumin	15-23	glutathione S-transferase alpha 1	Homo sapiens	83-90
19294764-6	2009	The expression of PPARdelta, 14-3-3epsilon and VEGF was reduced and the activity of beta-catenin/Tcf-4 signaling was inhibited by curcumin treatment.	Curcumin	130-138	transcription factor 4	Homo sapiens	97-102
19175364-0	2009	Curcumin protects PC12 cells from corticosterone-induced cytotoxicity: possible involvement of the ERK1/2 pathway.	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	99-105
19175364-7	2009	Western blot analysis showed that corticosterone increased ERK1/2 phosphorylation in PC12 cells and curcumin 10(-9) M to 10(-6) M significantly inhibited corticosterone-induced ERK1/2 phosphorylation in PC12 cells in a dose-dependent manner.	Curcumin	100-108	mitogen activated protein kinase 3	Rattus norvegicus	177-183
19175364-8	2009	These results suggest that curcumin is able to protect PC12 cells which may be associated with inhibition of ERK phosphorylation.	Curcumin	27-35	mitogen activated protein kinase 3	Rattus norvegicus	109-112
19221248-9	2009	All cell lines had similar NF-kappa beta levels; however, UM-SCC1 and UM-SCC14A had significantly higher Ikappa beta kinase levels and required considerably higher doses of curcumin before inhibition of IL-6 and IL-8 occurred.	Curcumin	173-181	protein tyrosine phosphatase receptor type J	Homo sapiens	61-65
18841445-7	2009	Based on studies in wild type and abcg2-/- mice, we observed that oral curcumin increased Cmax and relative bioavailability of sulfasalazine by selectively inhibiting ABCG2 function.	Curcumin	71-79	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	34-39
18841445-7	2009	Based on studies in wild type and abcg2-/- mice, we observed that oral curcumin increased Cmax and relative bioavailability of sulfasalazine by selectively inhibiting ABCG2 function.	Curcumin	71-79	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	167-172
18841445-10	2009	5:1995-2006, 2006) and provides the first in vivo evidence for the inhibition by curcumin of ABCG2-mediated efflux of sulfasalazine in mice.	Curcumin	81-89	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	93-98
18841445-11	2009	Based on these studies, we propose that non-toxic concentrations of curcumin may be used to enhance drug exposure when the rate-limiting step of drug absorption and/or tissue distribution is impacted by ABCG2.	Curcumin	68-76	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	203-208
18761777-7	2009	Curcumin, but not rutin, significantly reduced histological signs of colonic inflammation in mdr1a-/- mice.	Curcumin	0-8	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	93-98
19194552-7	2009	Pre-treatment of cells with AP-1 inhibitor, curcumin, blocked aldosterone-induced AP-1 DNA binding activity as well as aldosterone-induced TGF-beta(1) production.	Curcumin	44-52	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	28-32
19194552-7	2009	Pre-treatment of cells with AP-1 inhibitor, curcumin, blocked aldosterone-induced AP-1 DNA binding activity as well as aldosterone-induced TGF-beta(1) production.	Curcumin	44-52	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	82-86
18716759-6	2009	In contrast, curcumin induced glutathione depletion, caspase-3 activation, necrosis, and apoptosis.	Curcumin	13-21	caspase 3	Rattus norvegicus	53-62
19484960-16	2009	CONCLUSIONS: Curcumin can induce apoptosis of pulmonary fibroblasts in rats with bleomycin-induced pulmonary fibrosis and the mechanism may be related to the activation of Caspase-3, Caspase-8, and Caspase-9.	Curcumin	13-21	caspase 3	Rattus norvegicus	172-181
18784349-2	2008	In recent studies, curcumin has been shown to inhibit PSC proliferation via an extracellular signal-regulated kinase (ERK)1/2-dependent mechanism.	Curcumin	19-27	mitogen activated protein kinase 3	Rattus norvegicus	79-125
18784349-7	2008	Curcumin induced HO-1 gene expression in PSCs in a time- and dose-dependent manner and inhibited PDGF-mediated ERK1/2 phosphorylation and PSC proliferation.	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	111-117
19383353-5	2008	Upon treatment with curcumin, IL-6/sIL-6R-induced STAT3 and Erk phosphorylation was dramatically reduced in the co-cultured cells.	Curcumin	20-28	STIL centriolar assembly protein	Homo sapiens	35-38
19383353-7	2008	In a combination treatment with curcumin and bortezomib, IL-6/sIL-6R-induced STAT3 and Erk phosphorylation was effectively inhibited.	Curcumin	32-40	STIL centriolar assembly protein	Homo sapiens	62-65
19020741-0	2008	AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells.	Curcumin	14-22	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-4
19020741-3	2008	Our study demonstrated that chemopreventive agent curcumin strongly activates AMPK in a p38-dependent manner in CaOV3 ovarian cancer cells.	Curcumin	50-58	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	78-82
19020741-4	2008	Pretreatment of cells with compound C (AMPK inhibitor) and SB203580 (p38 inhibitor) attenuates curcumin-induced cell death.	Curcumin	95-103	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	39-43
19020741-6	2008	Collectively, our data suggest that AMPK is a new molecular target of curcumin and AMPK activation partially contributes to the cytotoxic effect of curcumin in ovarian cancer cells.	Curcumin	70-78	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	36-40
19020741-6	2008	Collectively, our data suggest that AMPK is a new molecular target of curcumin and AMPK activation partially contributes to the cytotoxic effect of curcumin in ovarian cancer cells.	Curcumin	148-156	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	36-40
19020741-6	2008	Collectively, our data suggest that AMPK is a new molecular target of curcumin and AMPK activation partially contributes to the cytotoxic effect of curcumin in ovarian cancer cells.	Curcumin	148-156	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	83-87
18835569-14	2008	Our results also showed that pre-treatment of U937 cells with AP-1 inhibitor, curcumin, or the PTK specific inhibitor, herbimycin A or genistein, prior to exposure to Nano-Co, significantly abolished Nano-Co-induced pro-MMP-2 and-9 activity.	Curcumin	78-86	matrix metallopeptidase 2	Homo sapiens	220-225
19198150-11	2008	Curcumin treatment educes apoptosis of cells that express PMP22 point mutation and partially mitigates the severe neuropathy phenotype of Trembler-J mouse model in a dose-dependent manner.	Curcumin	0-8	peripheral myelin protein 22	Mus musculus	58-63
19176142-0	2008	[The study of insulin resistance and leptin resistance on the model of simplicity obesity rats by curcumin].	Curcumin	98-106	leptin	Rattus norvegicus	37-43
19176142-1	2008	OBJECTIVE: To evaluate the insulin and leptin resistance of curcumin on simplicity obesity rats.	Curcumin	60-68	leptin	Rattus norvegicus	39-45
19176142-9	2008	RESULTS: Given 4 weeks the different dose of curcumin on the simplicity obesity rats, the significant diminished weight (435.0 +/- 37.6) g and content of lipocyte (4.78 +/- 1.87) g as compared with the obesity model control (492.3 +/- 14.8) g and (8.94 +/- 1.88) g (t values were 4.484 and 4.961 respectively, P &lt; 0.01), level of blood sugar (4.50 +/- 0.09) mmol/L, insulin (7.43 +/- 0.65) mmol/L, leptin (3.40 +/- 0.39) mmol/L and TNF-alpha (2.42 +/- 0.19) ng/ml were significantly decreased than those of adiposity model rats (4.94 +/- 0.12) mmol/L, (9.30 +/- 0.21) mmol/L, (4.40 +/- 0.23) mmol/L and (2.86 +/- 0.49) ng/ml (t values were 8.297, 7.743, 6.247 and 2.368 respectively, P &lt; 0.05), and there was no significant difference with the control group (4.30 +/- 0.14) mmol/L on the level of blood sugar (t = 0.399, P &gt; 0.05).	Curcumin	45-53	leptin	Rattus norvegicus	401-407
19176142-11	2008	CONCLUSION: By diminishing the sediment of fat, relaxing the lymphatic return, and refraining the apoptosis of beta cells, the curcumin might significantly decrease the level of insulin resistance and leptin resistance caused by the high fat diet.	Curcumin	127-135	leptin	Rattus norvegicus	201-207
18452714-7	2008	Furthermore, this up-regulation of COX-2 mRNA and protein was blocked by selective inhibitors of AP-1 and NF-kappaB, curcumin and helenalin, respectively.	Curcumin	117-125	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	35-40
18299980-4	2008	We have identified also several new genes, up- or downregulated by curcumin, namely, aldo-keto reductase, glucose-6-phosphate dehydrogenase, and aldehyde oxidase that protect against oxidative stress.	Curcumin	67-75	glucose-6-phosphate dehydrogenase	Rattus norvegicus	106-139
18593918-7	2008	Our data show that curcumin reduces RON expression by affecting p65 protein expression and transcriptional activity.	Curcumin	19-27	RELA proto-oncogene, NF-kB subunit	Homo sapiens	64-67
18545934-6	2008	The inhibition of [3H]-thymidine incorporation by IL-1beta was partially reversed with SB203580, SP600125 or curcumin, but not PDTC.	Curcumin	109-117	interleukin 1 beta	Bos taurus	50-58
19080374-8	2008	Curcumin could prevent CDK4 protein expression level decrease but not cyclin D1 protein.	Curcumin	0-8	cyclin dependent kinase 4	Homo sapiens	23-27
17922140-9	2008	Treatment of these cells with Stat3 siRNA or curcumin, which inhibited Stat3 phosphorylation, resulted in reduction of the NNMT level.	Curcumin	45-53	nicotinamide N-methyltransferase	Homo sapiens	123-127
18381954-8	2008	Moreover, curcumin suppressed NF-kappaB activity and the expression of NF-kappaB-regulated gene products (cyclin D1, c-myc, Bcl-2, Bcl-xL, cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase-9, and vascular endothelial growth factor), many of which were induced by radiation therapy and mediate radioresistance.	Curcumin	10-18	BCL2-like 1	Mus musculus	131-137
18381954-8	2008	Moreover, curcumin suppressed NF-kappaB activity and the expression of NF-kappaB-regulated gene products (cyclin D1, c-myc, Bcl-2, Bcl-xL, cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase-9, and vascular endothelial growth factor), many of which were induced by radiation therapy and mediate radioresistance.	Curcumin	10-18	prostaglandin-endoperoxide synthase 2	Mus musculus	182-226
18292803-8	2008	Our results indicate that curcumin has the potential to protect against cardiac hypertrophy, inflammation, and fibrosis through suppression of p300-HAT activity and downstream GATA4, NF-kappaB, and TGF-beta-Smad signaling pathways.	Curcumin	26-34	transforming growth factor, beta 1	Mus musculus	198-206
18187158-0	2008	Curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells.	Curcumin	0-8	ornithine decarboxylase 1	Homo sapiens	38-61
18187158-5	2008	In this study, we found that enzyme activity and protein expression of ODC were reduced during curcumin treatment.	Curcumin	95-103	ornithine decarboxylase 1	Homo sapiens	71-74
18187158-6	2008	Overexpression of ODC in human promyelocytic leukemia HL-60 parental cells could reduce curcumin-induced apoptosis, which leads to loss of mitochondrial membrane potential (Deltapsi(m)), through reducing intracellular ROS.	Curcumin	88-96	ornithine decarboxylase 1	Homo sapiens	18-21
18187158-7	2008	Moreover, ODC overexpression prevented cytochrome c release and the activation of caspase-9 and caspase-3 following curcumin treatment.	Curcumin	116-124	ornithine decarboxylase 1	Homo sapiens	10-13
18187158-8	2008	These results demonstrate that curcumin-induced apoptosis occurs through a mechanism of down-regulating ODC and along a ROS-dependent mitochondria-mediated pathway.	Curcumin	31-39	ornithine decarboxylase 1	Homo sapiens	104-107
17965732-0	2008	Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling.	Curcumin	0-8	cellular communication network factor 2	Homo sapiens	18-49
17965732-2	2008	We previously reported that curcumin, the yellow pigment in curry, suppressed ctgf expression, leading to decreased production of ECM by HSC.	Curcumin	28-36	cellular communication network factor 2	Homo sapiens	78-82
17965732-3	2008	The purpose of this study is to evaluate signal transduction pathways involved in the curcumin suppression of ctgf expression in HSC.	Curcumin	86-94	cellular communication network factor 2	Homo sapiens	110-114
17965732-6	2008	RESULTS: Suppression of ctgf expression by curcumin was dose-dependently reversed by lipopolysaccharide (LPS), an NF-kappaB activator.	Curcumin	43-51	cellular communication network factor 2	Homo sapiens	24-28
18683733-6	2008	RESULTS: Curcumin reduced the activities of MMP-2 and MMP-9 on a dose-dependent manner.	Curcumin	9-17	matrix metallopeptidase 2	Homo sapiens	44-49
18683733-8	2008	CONCLUSIONS: Curcumin can suppress Tca8113 invasion and migration by reducing the activities of MMP-2 and MMP-9.	Curcumin	13-21	matrix metallopeptidase 2	Homo sapiens	96-101
17962980-9	2008	Curcumin, EGCG, and resveratrol increased exon 7 inclusion of SMN2 transcripts in transient reporter assays.	Curcumin	0-8	survival of motor neuron 2, centromeric	Homo sapiens	62-66
18302884-2	2008	METHODS: RAW264.7 cells were treated with AP-1 inhibitor Curcumin.	Curcumin	57-65	jun proto-oncogene	Mus musculus	42-46
18302884-6	2008	RESULTS: The nucleoprotein expression of c-jun and c-fos in 10 and 20 micromol/L Curcumin prevention group (1.150 +/- 0.020, 1.010 +/- 0.108, 80.430 +/- 0.023, 0.256 +/- 0.015) were lower than those in silica-stimulated group (1.550 +/- 0.029, 0.860 +/- 0.036) (P &lt; 0.01).	Curcumin	81-89	jun proto-oncogene	Mus musculus	41-46
18302884-7	2008	In 20 micromol/L Curcumin prevention group and silica stimulated group, the expression of TNF-alpha protein were 23.58 +/- 45.78 and 32.12 +/- 5.34, and the expression of TGF-beta(1) protein were 1582.18 +/- 437.52 and 55.60 +/- 5.51 (P &lt; 0.05 =; the expression of TNF-alpha, TGF-beta(1) mRNA were 0.74 +/- 0.01, 0.22 +/- 0.04 and 2.27 +/- 0.33, 2.96 +/- 0.15 (P &lt; 0.05 =.	Curcumin	17-25	transforming growth factor, beta 1	Mus musculus	171-182
18302884-7	2008	In 20 micromol/L Curcumin prevention group and silica stimulated group, the expression of TNF-alpha protein were 23.58 +/- 45.78 and 32.12 +/- 5.34, and the expression of TGF-beta(1) protein were 1582.18 +/- 437.52 and 55.60 +/- 5.51 (P &lt; 0.05 =; the expression of TNF-alpha, TGF-beta(1) mRNA were 0.74 +/- 0.01, 0.22 +/- 0.04 and 2.27 +/- 0.33, 2.96 +/- 0.15 (P &lt; 0.05 =.	Curcumin	17-25	transforming growth factor, beta 1	Mus musculus	279-290
17975885-11	2007	In conclusion, the present study identifies the nature of the diastereoisomeric monoglutathionyl curcumin conjugates, CURSG-1 and CURSG-2 formed in biological systems, and reveals that conjugate formation is catalyzed by GSTM1a-1a, GSTA1-1, and/or GSTP1-1 with different stereoselective preference.	Curcumin	97-105	glutathione S-transferase alpha 1	Homo sapiens	232-239
17885582-10	2007	A curcumin dose-dependent inhibition of NF-kappaB-driven reporter activity correlated with decreased levels of phospho-IkappaBalpha, and decreased expression of NF-kappaB-target genes COX-2 and cyclin D1.	Curcumin	2-10	cytochrome c oxidase II, mitochondrial	Mus musculus	184-189
17979888-0	2007	Curcumin modulation of IFN-beta and IL-12 signalling and cytokine induction in human T cells.	Curcumin	0-8	interferon beta 1	Homo sapiens	23-31
17979888-7	2007	We report that curcumin decreases IL-12-induced STAT4 phosphorylation, IFN-gamma production, and IL-12 Rbeta1 and beta2 expression.	Curcumin	15-23	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	114-119
17979888-8	2007	IFN-beta-induced STAT4 phosphorylation, IL-10 production and IFN receptor (IFNAR) subunits 1 and 2 expression were enhanced by curcumin.	Curcumin	127-135	interferon beta 1	Homo sapiens	0-8
17468862-1	2007	OBJECTIVE: To investigate the effect of concomitantly administered curcumin on the pharmacokinetics of the beta1 adrenoceptor blocker talinolol.	Curcumin	67-75	adrenoceptor beta 1	Homo sapiens	107-125
17596214-7	2007	Curcumin-sensitized glioma cells to several clinically utilized chemotherapeutic agents (cisplatin, etoposide, camptothecin, and doxorubicin) and radiation, effects correlated with reduced expression of bcl-2 and IAP family members as well as DNA repair enzymes (MGMT, DNA-PK, Ku70, Ku80, and ERCC-1).	Curcumin	0-8	X-ray repair cross complementing 5	Homo sapiens	283-287
17277231-3	2007	Curcumin treatment resulted an increase in the protein levels of both Bax and Bak, and mitochondrial translocation and activation of Bax in MEFs to trigger drop in mitochondrial membrane potential, cytosolic release of apoptogenic molecules [cytochrome c and second mitochondria-derived activator of caspases (Smac)/direct inhibitor of apoptosis protein-binding protein with low isoelectric point], activation of caspase-9 and caspase-3 and ultimately apoptosis.	Curcumin	0-8	caspase 9	Mus musculus	413-422
17277231-4	2007	Furthermore, MEFs derived from Bax and Bak double-knockout (DKO) mice exhibited even greater protection against curcumin-induced release of cytochrome c and Smac, activation of caspase-3 and caspase-9 and induction of apoptosis compared with wild-type MEFs or single-knockout Bax(-/-) or Bak(-/-) MEFs.	Curcumin	112-120	caspase 9	Mus musculus	191-200
17299794-7	2007	Moreover, pretreatment with p300 inhibitor (curcumin) also blocked ICAM-1 expression.	Curcumin	44-52	E1A binding protein p300	Homo sapiens	28-32
17518770-7	2007	CONCLUSIONS: Using HaCat, we showed that curcumin and genistein can revert nickel-induced MMP-2 upregulation.	Curcumin	41-49	matrix metallopeptidase 2	Homo sapiens	90-95
17171638-7	2007	Curcumin increased the expression of the phosphorylated forms of PTK, PDK1, and PKC-delta, which was attenuated by either GSH or NAC and potentiated by BSO.	Curcumin	0-8	protein kinase C delta	Homo sapiens	80-89
17171638-8	2007	Furthermore, selective inhibitors of PI3K and PKC-delta attenuated curcumin-induced GADD153 upregulation.	Curcumin	67-75	protein kinase C delta	Homo sapiens	46-55
17291458-7	2007	Treatment of chondrocytes with curcumin suppressed IL-1beta-induced NF-kappaB activation via inhibition of IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation and p65 nuclear translocation.	Curcumin	31-39	RELA proto-oncogene, NF-kB subunit	Homo sapiens	163-166
17291458-7	2007	Treatment of chondrocytes with curcumin suppressed IL-1beta-induced NF-kappaB activation via inhibition of IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation and p65 nuclear translocation.	Curcumin	31-39	RELA proto-oncogene, NF-kB subunit	Homo sapiens	187-190
17131042-7	2007	These doses of curcumin affected neither the level of intracellular glutathione nor the level of reactive oxygen species, but inactivated JNK and p38 significantly.	Curcumin	15-23	mitogen-activated protein kinase 14	Mus musculus	146-149
17148446-0	2007	Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes.	Curcumin	0-8	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-23
17148446-6	2007	Curcumin treatment inhibits the novel protein kinase C-, Ras-, and MEKK1-dependent activation of hINV promoter activity and reduces the differentiation agent-dependent increase in AP1 factor level and DNA binding.	Curcumin	0-8	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	67-72
17148446-6	2007	Curcumin treatment inhibits the novel protein kinase C-, Ras-, and MEKK1-dependent activation of hINV promoter activity and reduces the differentiation agent-dependent increase in AP1 factor level and DNA binding.	Curcumin	0-8	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	180-183
17569210-6	2007	Curcumin arrested the cell cycle by preventing the expression of cyclin D1, cdk-1 and cdc-25.	Curcumin	0-8	cyclin D1	Homo sapiens	65-74
17177975-0	2007	Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway.	Curcumin	16-24	CD28 molecule	Homo sapiens	58-62
17177975-0	2007	Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway.	Curcumin	16-24	CD80 molecule	Homo sapiens	74-78
17177975-5	2007	Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4.	Curcumin	15-23	CD28 molecule	Homo sapiens	95-99
17177975-5	2007	Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4.	Curcumin	15-23	CD80 molecule	Homo sapiens	104-108
16934299-6	2006	Indeed, curcumin altered biochemical patterns induced by LPS such as phosphorylation of all mitogen-activated protein kinases (MAPKs), and DNA binding activities of nuclear factor-kappaB (NF-kappaB) and activator protein (AP)-1, assessed by reporter gene assay.	Curcumin	8-16	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	203-227
21677791-7	2011	The release of cytochrome c from the mitochondria into the cytosol was reduced fourfold by in vivo diferuloylmethane treatment, suggesting that the drug was acting to inhibit the intrinsic apoptotic pathway.	Curcumin	99-116	cytochrome c, somatic b	Danio rerio	15-27
22180352-0	2011	Curcumin mediates presenilin-1 activity to reduce beta-amyloid production in a model of Alzheimer"s Disease.	Curcumin	0-8	presenilin 1	Homo sapiens	18-30
22180352-11	2011	Treatment with curcumin also decreased both PS1 and GSK-3beta mRNA and protein levels in a dose- and time-dependent manner.	Curcumin	15-23	presenilin 1	Homo sapiens	44-47
22180352-11	2011	Treatment with curcumin also decreased both PS1 and GSK-3beta mRNA and protein levels in a dose- and time-dependent manner.	Curcumin	15-23	glycogen synthase kinase 3 alpha	Homo sapiens	52-61
22180352-12	2011	Furthermore, curcumin increased the inhibitory phosphorylation of GSK-3beta protein at Ser9.	Curcumin	13-21	glycogen synthase kinase 3 alpha	Homo sapiens	66-75
22180352-13	2011	Therefore, we propose that curcumin decreases Abeta production by inhibiting GSK-3beta-mediated PS1 activation.	Curcumin	27-35	glycogen synthase kinase 3 alpha	Homo sapiens	77-86
22180352-13	2011	Therefore, we propose that curcumin decreases Abeta production by inhibiting GSK-3beta-mediated PS1 activation.	Curcumin	27-35	presenilin 1	Homo sapiens	96-99
21073732-7	2010	RESULTS: Curcumin enhanced the phosphorylation of both p38MAPK and downstream HSP25; inhibited COX-2; induced a trend towards attenuation of F- to G-actin cleavage; and dramatically inhibited the activation of caspase-3 in vitro.	Curcumin	9-17	mitogen-activated protein kinase 14	Mus musculus	55-62
21073732-7	2010	RESULTS: Curcumin enhanced the phosphorylation of both p38MAPK and downstream HSP25; inhibited COX-2; induced a trend towards attenuation of F- to G-actin cleavage; and dramatically inhibited the activation of caspase-3 in vitro.	Curcumin	9-17	cytochrome c oxidase II, mitochondrial	Mus musculus	95-100
20977462-0	2010	Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase.	Curcumin	0-8	solute carrier family 2 member 4	Homo sapiens	103-124
20977462-5	2010	We hypothesized that leptin stimulated HSC activation by elevating the level of intracellular glucose, which was eliminated by curcumin by inhibiting the membrane translocation of glucose transporter-4 (GLUT4) and inducing the conversion of glucose to glucose-6-phosphate (G-6-P).	Curcumin	127-135	solute carrier family 2 member 4	Homo sapiens	180-201
20977462-5	2010	We hypothesized that leptin stimulated HSC activation by elevating the level of intracellular glucose, which was eliminated by curcumin by inhibiting the membrane translocation of glucose transporter-4 (GLUT4) and inducing the conversion of glucose to glucose-6-phosphate (G-6-P).	Curcumin	127-135	solute carrier family 2 member 4	Homo sapiens	203-208
20977462-10	2010	Curcumin suppressed the leptin-induced membrane translocation of GLUT4 by interrupting the insulin receptor substrates/phosphatidyl inositol 3-kinase/AKT signalling pathway.	Curcumin	0-8	solute carrier family 2 member 4	Homo sapiens	65-70
20977462-10	2010	Curcumin suppressed the leptin-induced membrane translocation of GLUT4 by interrupting the insulin receptor substrates/phosphatidyl inositol 3-kinase/AKT signalling pathway.	Curcumin	0-8	insulin receptor	Homo sapiens	91-107
21329002-0	2010	[Effects of curcumin on apoptosis and caspase-3 expression in cortex tissue in rats with hypoxic ischemic brain damage].	Curcumin	12-20	caspase 3	Rattus norvegicus	38-47
20163327-0	2010	Curcumin inhibits TNFalpha-induced lectin-like oxidised LDL receptor-1 (LOX-1) expression and suppresses the inflammatory response in human umbilical vein endothelial cells (HUVECs) by an antioxidant mechanism.	Curcumin	0-8	oxidized low density lipoprotein receptor 1	Homo sapiens	35-70
20163327-0	2010	Curcumin inhibits TNFalpha-induced lectin-like oxidised LDL receptor-1 (LOX-1) expression and suppresses the inflammatory response in human umbilical vein endothelial cells (HUVECs) by an antioxidant mechanism.	Curcumin	0-8	oxidized low density lipoprotein receptor 1	Homo sapiens	72-77
20538041-7	2010	However, after a longer duration treatment, two other compounds (demethoxycurcumin and curcumin) also increased PSD-95 to 331.7 and 226.2% respectively at 30 mg/kg.	Curcumin	74-82	discs large MAGUK scaffold protein 4	Rattus norvegicus	112-118
20627087-5	2010	Further studies showed that curcumin altered miRNA expression; in particular, significantly downregulated the expression of miR-186 * in A549/DDP.	Curcumin	28-36	microRNA 186	Homo sapiens	124-131
20627087-6	2010	In addition, transfection of cells with a miR-186 * inhibitor promoted A549/DDP apoptosis, and overexpression of miR-186 * significantly inhibited curcumin-induced apoptosis in A549/DDP cells.	Curcumin	147-155	microRNA 186	Homo sapiens	42-49
20627087-6	2010	In addition, transfection of cells with a miR-186 * inhibitor promoted A549/DDP apoptosis, and overexpression of miR-186 * significantly inhibited curcumin-induced apoptosis in A549/DDP cells.	Curcumin	147-155	microRNA 186	Homo sapiens	113-120
20627087-7	2010	These observations suggest that miR-186 * may serve as a potential gene therapy target for refractory lung cancer that is sensitive to curcumin.	Curcumin	135-143	microRNA 186	Homo sapiens	32-39
20127863-0	2010	Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPalpha during oral cancer suppression.	Curcumin	0-8	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	80-90
20127863-4	2010	Promoter deletion mapping identified a region (nt -71 to nt -59 relative to the transcription start site) as containing a C/EBPalpha-binding element that is indispensable for curcumin-mediated IGFBP-5 upregulation.	Curcumin	175-183	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	122-132
20127863-5	2010	Chromatin immunoprecipitation assays revealed that in vivo binding of C/EBPalpha to this region was remarkably increased in the presence of curcumin.	Curcumin	140-148	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	70-80
20127863-6	2010	Curcumin increased nuclear C/EBPalpha expression and IGFBP-5 expression through p38 activation and this was abrogated by SB203580 treatment.	Curcumin	0-8	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	27-37
20127863-6	2010	Curcumin increased nuclear C/EBPalpha expression and IGFBP-5 expression through p38 activation and this was abrogated by SB203580 treatment.	Curcumin	0-8	mitogen-activated protein kinase 14	Mus musculus	80-83
20127863-9	2010	We conclude that curcumin activates p38, which, in turn, activates the C/EBPalpha transactivator by interacting with binding elements in the IGFBP-5 promoter.	Curcumin	17-25	mitogen-activated protein kinase 14	Mus musculus	36-39
20127863-9	2010	We conclude that curcumin activates p38, which, in turn, activates the C/EBPalpha transactivator by interacting with binding elements in the IGFBP-5 promoter.	Curcumin	17-25	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	71-81
20127863-10	2010	The consequential upregulation of C/EBPalpha and IGFBP-5 by curcumin is crucial to the suppression of oral carcinogenesis.	Curcumin	60-68	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	34-44
20462637-7	2010	Co-expression of I kappaB alpha inhibited p65-mediated FOXP3 proximal promoter transactivation, and the NF-kappaB inhibitor curcumin reduced Foxp3 neoexpression in IL-2/CD3/CD28/TGF-beta stimulated PBMCs.	Curcumin	124-132	forkhead box P3	Homo sapiens	141-146
20462637-7	2010	Co-expression of I kappaB alpha inhibited p65-mediated FOXP3 proximal promoter transactivation, and the NF-kappaB inhibitor curcumin reduced Foxp3 neoexpression in IL-2/CD3/CD28/TGF-beta stimulated PBMCs.	Curcumin	124-132	CD28 molecule	Homo sapiens	173-177
20467147-6	2010	Curcumin inhibits p300-mediated nuclear acetylation, suggesting its usefulness in HF treatment.	Curcumin	0-8	E1A binding protein p300	Homo sapiens	18-22
20200402-2	2010	The PGN-induced COX-2 expression was attenuated by the DNs of ASK1, JNK1, JNK2, a JNK inhibitor (SP600125), and an AP-1 inhibitor (curcumin).	Curcumin	131-139	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	4-7
20369229-0	2010	Involvement of PPAR-gamma in curcumin-mediated beneficial effects in experimental dementia.	Curcumin	29-37	peroxisome proliferator activated receptor gamma	Mus musculus	15-25
20369229-9	2010	Furthermore, the noted beneficial effect of curcumin on STZ-induced dementia was significantly abolished by pretreatment with PPAR-gamma receptor antagonist bisphenol-A-diglycidyl ether, i.e., BADGE (30 mg/kg intraperitoneally (i.p.)).	Curcumin	44-52	peroxisome proliferator activated receptor gamma	Mus musculus	126-136
20369229-10	2010	It may be concluded that the beneficial effects of curcumin are mediated through the activation of PPAR-gamma receptors.	Curcumin	51-59	peroxisome proliferator activated receptor gamma	Mus musculus	99-109
20235152-8	2010	Overexpression of SOCS-3 in curcumin-treated cells increased expression of phosphorylated STAT-3 and resulted in increased cell viability.	Curcumin	28-36	suppressor of cytokine signaling 3	Homo sapiens	18-24
20138829-5	2010	In this study we found that curcumin induces apoptotic cell death in MCF-7 cells, as assessed by MTT assay, DNA ladder formation, PARP cleavage, p53 and Bax induction.	Curcumin	28-36	collagen type XI alpha 2 chain	Homo sapiens	130-134
20138829-6	2010	At apoptotic inducing concentration, curcumin induces a dramatic Akt phosphorylation, accompanied by an increased phosphorylation of glycogen synthase kinase 3beta (GSK3beta), which has been considered to be a pro-growth signaling molecule.	Curcumin	37-45	glycogen synthase kinase 3 beta	Homo sapiens	133-163
20138829-6	2010	At apoptotic inducing concentration, curcumin induces a dramatic Akt phosphorylation, accompanied by an increased phosphorylation of glycogen synthase kinase 3beta (GSK3beta), which has been considered to be a pro-growth signaling molecule.	Curcumin	37-45	glycogen synthase kinase 3 beta	Homo sapiens	165-173
20138829-8	2010	The inhibitor LY290042 was capable of attenuating curcumin-induced Akt phosphorylation and activation of GSK3beta.	Curcumin	50-58	glycogen synthase kinase 3 beta	Homo sapiens	105-113
20332524-7	2010	Curcumin-similar to PPARgamma synthetic agonist troglitazone-directly inhibited TNF-alpha-induced inflammatory activation of cholangiocytes in vitro, whereas these beneficial effects of curcumin were largely blocked by a PPARgamma synthetic antagonist.	Curcumin	186-194	peroxisome proliferator activated receptor gamma	Mus musculus	221-230
20332524-8	2010	In addition, curcumin blocked proliferation and activation of portal MFBs by inhibiting ERK1/2 phosphorylation, thus contributing to reduced fibrogenesis.	Curcumin	13-21	mitogen-activated protein kinase 3	Mus musculus	88-94
20332524-9	2010	CONCLUSIONS: These results show that curcumin may have multiple targets in liver including activation of PPARgamma in cholangiocytes and inhibition of ERK1/2 signalling in MFBs, thereby modulating several central cellular events in a mouse model of cholangiopathy.	Curcumin	37-45	peroxisome proliferator activated receptor gamma	Mus musculus	105-114
20332524-9	2010	CONCLUSIONS: These results show that curcumin may have multiple targets in liver including activation of PPARgamma in cholangiocytes and inhibition of ERK1/2 signalling in MFBs, thereby modulating several central cellular events in a mouse model of cholangiopathy.	Curcumin	37-45	mitogen-activated protein kinase 3	Mus musculus	151-157
20569277-0	2010	Grp94 acts as a mediator of curcumin-induced antioxidant defence in myogenic cells.	Curcumin	28-36	heat shock protein 90, beta (Grp94), member 1	Mus musculus	0-5
20569277-3	2010	A 3-hr curcumin administration (5-10 microM) increased protein levels of the ER chaperone Grp94, without affecting those of Grp78, calreticulin and haeme-oxygenase-1 (HO-1).	Curcumin	7-15	heat shock protein 90, beta (Grp94), member 1	Mus musculus	90-95
20569277-6	2010	The delayed cytoprotection induced by curcumin acted through Grp94, because the curcumin-induced increase in Grp94 expression was hampered by either stable or transient transfection with antisense cDNA; in these latter cells, the extent of total protein oxidation, as well as the translocation of NF-kappaB to the nucleus, and the percentage of apoptotic cells were comparable to those observed in both curcumin-untreated wild-type and empty vector transfected cells.	Curcumin	38-46	heat shock protein 90, beta (Grp94), member 1	Mus musculus	61-66
20569277-6	2010	The delayed cytoprotection induced by curcumin acted through Grp94, because the curcumin-induced increase in Grp94 expression was hampered by either stable or transient transfection with antisense cDNA; in these latter cells, the extent of total protein oxidation, as well as the translocation of NF-kappaB to the nucleus, and the percentage of apoptotic cells were comparable to those observed in both curcumin-untreated wild-type and empty vector transfected cells.	Curcumin	38-46	heat shock protein 90, beta (Grp94), member 1	Mus musculus	109-114
20569277-6	2010	The delayed cytoprotection induced by curcumin acted through Grp94, because the curcumin-induced increase in Grp94 expression was hampered by either stable or transient transfection with antisense cDNA; in these latter cells, the extent of total protein oxidation, as well as the translocation of NF-kappaB to the nucleus, and the percentage of apoptotic cells were comparable to those observed in both curcumin-untreated wild-type and empty vector transfected cells.	Curcumin	80-88	heat shock protein 90, beta (Grp94), member 1	Mus musculus	61-66
20569277-6	2010	The delayed cytoprotection induced by curcumin acted through Grp94, because the curcumin-induced increase in Grp94 expression was hampered by either stable or transient transfection with antisense cDNA; in these latter cells, the extent of total protein oxidation, as well as the translocation of NF-kappaB to the nucleus, and the percentage of apoptotic cells were comparable to those observed in both curcumin-untreated wild-type and empty vector transfected cells.	Curcumin	80-88	heat shock protein 90, beta (Grp94), member 1	Mus musculus	109-114
20569277-6	2010	The delayed cytoprotection induced by curcumin acted through Grp94, because the curcumin-induced increase in Grp94 expression was hampered by either stable or transient transfection with antisense cDNA; in these latter cells, the extent of total protein oxidation, as well as the translocation of NF-kappaB to the nucleus, and the percentage of apoptotic cells were comparable to those observed in both curcumin-untreated wild-type and empty vector transfected cells.	Curcumin	80-88	heat shock protein 90, beta (Grp94), member 1	Mus musculus	61-66
20569277-6	2010	The delayed cytoprotection induced by curcumin acted through Grp94, because the curcumin-induced increase in Grp94 expression was hampered by either stable or transient transfection with antisense cDNA; in these latter cells, the extent of total protein oxidation, as well as the translocation of NF-kappaB to the nucleus, and the percentage of apoptotic cells were comparable to those observed in both curcumin-untreated wild-type and empty vector transfected cells.	Curcumin	80-88	heat shock protein 90, beta (Grp94), member 1	Mus musculus	109-114
19777504-2	2010	Here, we found that curcumin inhibited cell proliferation and motility with decreased activities of matrix metalloproteinase (MMP)-2/9 and decreased mRNA expressions of urokinase-type plasminogen activator (uPA) and its receptor uPAR in the highly invasive human YD-10B OSCC cells.	Curcumin	20-28	matrix metallopeptidase 2	Homo sapiens	100-132
19777504-4	2010	In conclusion, curcumin is one of the strong phytochemicals with antimotility activity of OSCC; the inhibitory effect of curcumin on the motility of YD-10B cells could result from its potential to inhibit the activation of ERK/MAP kinase and NF-kappaB that consequently down-regulate the mRNA expressions and activities of proteolytic enzymes such as uPA and MMP-2/9.	Curcumin	121-129	matrix metallopeptidase 2	Homo sapiens	359-366
20677554-0	2010	[Curcumin promoted the apoptosis of cisplain-resistant human lung carcinoma cells A549/DDP through down-regulating miR-186*].	Curcumin	1-9	microRNA 186	Homo sapiens	115-122
20677554-4	2010	The aim of this study is to illustrate whether Curcumin could promote the apoptosis of A549/DDP cells through regulating the expression of miR-186*.	Curcumin	47-55	microRNA 186	Homo sapiens	139-146
20677554-8	2010	RESULTS: The microarray chip results demonstrated: Curcumin altered the expression level of miRNAs compared with untreated control in A549/DDP cell line, miR-186* was significantly down-regulated after Curcumin treatment, which confirmed by quantitative real-time PCR.	Curcumin	51-59	microRNA 186	Homo sapiens	154-161
20677554-8	2010	RESULTS: The microarray chip results demonstrated: Curcumin altered the expression level of miRNAs compared with untreated control in A549/DDP cell line, miR-186* was significantly down-regulated after Curcumin treatment, which confirmed by quantitative real-time PCR.	Curcumin	202-210	microRNA 186	Homo sapiens	154-161
20677554-9	2010	Down-regulation of miR-186* expression by curcumin elevated the apoptosis, and the survival rate of A549/DDP cells decreased; but up-regulation of miR-186* expression by transfection its mimics restrained the apoptosis, the survival rate of A549/DDP cells increased, which were assayed by flow cytometry expriments and MTT method.	Curcumin	42-50	microRNA 186	Homo sapiens	19-26
20026325-14	2010	Curcumin completely abolished a hyperosmoticity-induced increase of NF-kappaB p65.	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	78-81
24926361-7	2014	In addition, curcumin inhibited the TNF-alpha-induced induction of MMP-2 activity and expression.	Curcumin	13-21	matrix metallopeptidase 2	Rattus norvegicus	67-72
24926361-11	2014	Therefore, these observations indicated that curcumin suppressed TNF-alpha-stimulated VSMC migration and partially prevented TNF-alpha-induced MMP-2 expression and activity in VSMCs via the NF-kappaB pathway.	Curcumin	45-53	matrix metallopeptidase 2	Rattus norvegicus	143-148
24626093-3	2014	At optimal concentrations, curcumin greatly reduced expression levels of stem cell markers (DCLK1/CD44/ALDHA1/Lgr5/Nanog) in three-dimensional spheroid cultures and tumor xenografts derived from colon cancer cells.	Curcumin	27-35	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	110-114
24671632-5	2014	Curcumin significantly induced the transcription of peroxisome proliferator-activated receptor (PPAR) gamma and mitochondrial transcription factor A (TFAM) in APOE3, but not in APOE4 mice.	Curcumin	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	52-107
20145018-4	2010	Similarly, cells suppressed for MLH1 or MSH2 expression by RNA interference displayed increased curcumin sensitivity.	Curcumin	96-104	mutS homolog 2	Homo sapiens	40-44
20127004-7	2010	Results from Western blotting showed that curcumin inhibited the protein levels of PKC, FAK, NF-kappaB p65 and Rho A leading to the inhibition of ERK1/2, MKK7, COX-2 and ROCK1, respectively, finally causing the inhibition of MMP-2 and -9 for the inhibition of migration and invasion of N18 cells.	Curcumin	42-50	mitogen activated protein kinase 3	Rattus norvegicus	146-152
20127004-7	2010	Results from Western blotting showed that curcumin inhibited the protein levels of PKC, FAK, NF-kappaB p65 and Rho A leading to the inhibition of ERK1/2, MKK7, COX-2 and ROCK1, respectively, finally causing the inhibition of MMP-2 and -9 for the inhibition of migration and invasion of N18 cells.	Curcumin	42-50	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	160-165
20127004-7	2010	Results from Western blotting showed that curcumin inhibited the protein levels of PKC, FAK, NF-kappaB p65 and Rho A leading to the inhibition of ERK1/2, MKK7, COX-2 and ROCK1, respectively, finally causing the inhibition of MMP-2 and -9 for the inhibition of migration and invasion of N18 cells.	Curcumin	42-50	matrix metallopeptidase 2	Rattus norvegicus	225-237
20097158-3	2010	We demonstrate that the polyphenolic phytochemicals curcumin and masoprocol can rescue PDI from becoming S-nitrosylated and maintain its catalytic function under conditions mimicking nitrosative stress by forming stable NOx adducts.	Curcumin	52-60	prolyl 4-hydroxylase subunit beta	Homo sapiens	87-90
20097158-5	2010	Our study suggests that curcumin and masoprocol can serve as lead-candidate prophylactics for reactive oxygen species induced chaperone damage, protein misfolding and neurodegenerative disease; importantly, they can play a vital role in sustaining traffic along the ER"s secretory pathway by preserving functional integrity of PDI.	Curcumin	24-32	prolyl 4-hydroxylase subunit beta	Homo sapiens	327-330
20040737-0	2010	Curcumin produces an antihyperalgesic effect via antagonism of TRPV1.	Curcumin	0-8	transient receptor potential cation channel subfamily V member 1	Homo sapiens	63-68
20040737-2	2010	The vanilloid moiety of curcumin is considered important for activation of the transient receptor potential vanilloid 1 (TRPV1), which plays an important role in nociception.	Curcumin	24-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	79-119
20040737-2	2010	The vanilloid moiety of curcumin is considered important for activation of the transient receptor potential vanilloid 1 (TRPV1), which plays an important role in nociception.	Curcumin	24-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	121-126
20040737-8	2010	Taken together, our results indicate that curcumin blocks capsaicin-induced TRPV1 activation and thereby inhibits TRPV1-mediated pain hypersensitivity.	Curcumin	42-50	transient receptor potential cation channel subfamily V member 1	Homo sapiens	76-81
20040737-8	2010	Taken together, our results indicate that curcumin blocks capsaicin-induced TRPV1 activation and thereby inhibits TRPV1-mediated pain hypersensitivity.	Curcumin	42-50	transient receptor potential cation channel subfamily V member 1	Homo sapiens	114-119
19447587-7	2010	Furthermore, the production of ROS and the nuclear translocation of NF-kappaB p50 and p65 induced by TNF-alpha were dose-dependently suppressed by curcumin pretreatment.	Curcumin	147-155	RELA proto-oncogene, NF-kB subunit	Homo sapiens	86-89
20593964-7	2010	Curcumin also exhibited protective action against the As III induced depletion of antioxidants like catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST) and glutathione (GSH) in mice liver tissue.	Curcumin	0-8	glutathione reductase	Mus musculus	174-195
20593964-7	2010	Curcumin also exhibited protective action against the As III induced depletion of antioxidants like catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST) and glutathione (GSH) in mice liver tissue.	Curcumin	0-8	glutathione reductase	Mus musculus	197-199
19996301-7	2009	We further show that curcumin, a dietary compound, can selectively inhibit ectopic fVII expression by targeting p300/CBP activity.	Curcumin	21-29	E1A binding protein p300	Homo sapiens	112-116
20032417-4	2009	The plant substance curcumin is a known activator of the transcription factor aryl hydrocarbon receptor (AhR), and has well-documented antileukemic effects.	Curcumin	20-28	aryl hydrocarbon receptor	Homo sapiens	78-103
20032417-4	2009	The plant substance curcumin is a known activator of the transcription factor aryl hydrocarbon receptor (AhR), and has well-documented antileukemic effects.	Curcumin	20-28	aryl hydrocarbon receptor	Homo sapiens	105-108
20032417-6	2009	We ask here whether direct AhR-activation by curcumin contributes to its antileukemic/apoptotic potential.	Curcumin	45-53	aryl hydrocarbon receptor	Homo sapiens	27-30
20032417-12	2009	CONCLUSION: We conclude that AhR is only marginally involved in the antileukemic effects of its ligand curcumin.	Curcumin	103-111	aryl hydrocarbon receptor	Homo sapiens	29-32
19714451-1	2009	PURPOSE: The purpose of the current study was to assess the effect of newly synthesized Curcumin analogs on COX-2 protein by molecular docking studies and by assessments of the effect of one such analog (CDF) on nuclear factor NF-kappaB and PGE(2).	Curcumin	88-96	cytochrome c oxidase II, mitochondrial	Mus musculus	108-113
19958643-9	2009	CONCLUSION: Curcumine inhibits migration and invasion of activated HSC by reducing MMP-2 expression and activity.	Curcumin	12-21	matrix metallopeptidase 2	Rattus norvegicus	83-88
19699734-1	2009	Curcumin is a potent inhibitor of the transcription factor activator protein-1 which plays an essential role in osteoclastogenesis.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	59-78
19699734-7	2009	When bone marrow cells were cultured with macrophage colony stimulating factor and receptor activator NF-kappaB ligand (RANKL), the increased activity to form TRAP-positive multinucleated cells and the increased levels of mRNA and protein of c-fos and c-jun in the cultured cells from diabetic rats decreased to control levels in the curcumin-supplemented rats.	Curcumin	334-342	TNF superfamily member 11	Rattus norvegicus	83-118
19699734-7	2009	When bone marrow cells were cultured with macrophage colony stimulating factor and receptor activator NF-kappaB ligand (RANKL), the increased activity to form TRAP-positive multinucleated cells and the increased levels of mRNA and protein of c-fos and c-jun in the cultured cells from diabetic rats decreased to control levels in the curcumin-supplemented rats.	Curcumin	334-342	TNF superfamily member 11	Rattus norvegicus	120-125
19288529-0	2009	Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells.	Curcumin	14-22	LOC100508689	Homo sapiens	71-76
19288529-3	2009	The results were as follows: (1) genistein and curcumin inhibited the production of MUC5AC mucin protein induced by EGF, dose-dependently; (2) genistein and curcumin also inhibited the expression of MUC5AC mucin gene induced by EGF.	Curcumin	47-55	LOC100508689	Homo sapiens	91-96
19685877-6	2009	Furthermore, EEAP, apigenin, curcumin, and pinocembrin decreased LPS-mediated induction of protein and mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in RAW 264.7 cells.	Curcumin	29-37	prostaglandin-endoperoxide synthase 2	Mus musculus	165-181
19685877-6	2009	Furthermore, EEAP, apigenin, curcumin, and pinocembrin decreased LPS-mediated induction of protein and mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in RAW 264.7 cells.	Curcumin	29-37	prostaglandin-endoperoxide synthase 2	Mus musculus	183-188
19763044-8	2009	Curcumin also suppressed the JNK and c-Jun activation in those cells.	Curcumin	0-8	jun proto-oncogene	Mus musculus	37-42
19763044-0	2009	Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway.	Curcumin	23-31	matrix metallopeptidase 13	Mus musculus	57-89
19769723-5	2009	Bay-11 and curcumin can significantly decrease MMP-2 activities to 13% and 29% in injured ACL fibroblasts, respectively, which implies the involvement of p65 subunits of nuclear factor kappaB and AP-1 pathways.	Curcumin	11-19	matrix metallopeptidase 2	Homo sapiens	47-52
19769723-5	2009	Bay-11 and curcumin can significantly decrease MMP-2 activities to 13% and 29% in injured ACL fibroblasts, respectively, which implies the involvement of p65 subunits of nuclear factor kappaB and AP-1 pathways.	Curcumin	11-19	RELA proto-oncogene, NF-kB subunit	Homo sapiens	154-157
19661333-5	2009	Curcumin decreased total expression of mTOR, Raptor and Rictor protein and mRNA levels.	Curcumin	0-8	regulatory associated protein of MTOR complex 1	Homo sapiens	45-51
19723094-0	2009	Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells.	Curcumin	57-65	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	25-29
19723094-4	2009	In this study we investigated the effects of curcumin on apoptosis and the regulatory effect of the AMPK-cyclooxygenase-2 (COX-2) pathway in curcumin-induced apoptosis.	Curcumin	141-149	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	100-104
19723094-6	2009	This study focused on exploiting curcumin to apply antitumorigenic effects through modulation of the AMPK-COX-2 cascade.	Curcumin	33-41	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	101-105
19723094-10	2009	Further study with AMPK synthetic inhibitor Compound C has shown that increased concentrations of Compound C would abolish AMPK expression, accompanied by a marked increase in COX-2 as well as pAkt expression in curcumin-treated HT-29 cells.	Curcumin	212-220	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	19-23
19723094-11	2009	By inhibiting AMPK with Compound C, we found that curcumin-treated colon cancer cells were no longer undergoing apoptosis; rather, they were proliferative.	Curcumin	50-58	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	14-18
19723094-12	2009	These results indicate that AMPK is crucial in apoptosis induced by curcumin and further that the pAkt-AMPK-COX-2 cascade or AMPK-pAkt-COX-2 pathway is important in cell proliferation and apoptosis in colon cancer cells.	Curcumin	68-76	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	28-32
19723094-12	2009	These results indicate that AMPK is crucial in apoptosis induced by curcumin and further that the pAkt-AMPK-COX-2 cascade or AMPK-pAkt-COX-2 pathway is important in cell proliferation and apoptosis in colon cancer cells.	Curcumin	68-76	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	103-107
19723094-12	2009	These results indicate that AMPK is crucial in apoptosis induced by curcumin and further that the pAkt-AMPK-COX-2 cascade or AMPK-pAkt-COX-2 pathway is important in cell proliferation and apoptosis in colon cancer cells.	Curcumin	68-76	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	103-107
19393301-7	2009	The curcumin diet counteracted the effects of FPI and elevated the levels of AMPK, uMtCK, COX-II in Cur/FPI rats as compared to RD/sham rats.	Curcumin	4-12	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	90-96
19764552-2	2009	METHODS: The effects of TGF-beta1, curcumin, PDTC and rosiglitazone on the expression of CTGF, NF-kappaB and AP-1 were evaluated with Western blot.	Curcumin	35-43	cellular communication network factor 2	Homo sapiens	89-93
19764552-9	2009	The CTGF protein levels were inhibited obviously after HLF-02 cells were incubated with PDTC or curcumin.	Curcumin	96-104	cellular communication network factor 2	Homo sapiens	4-8
19494316-6	2009	Thrombin-induced CTGF expression and CTGF-luciferase activity were inhibited by a protease-activated receptor 1 antagonist (SCH79797), the dominant-negative mutants (DNs) of ASK1 and JNK1/2, and an AP-1 inhibitor (curcumin).	Curcumin	214-222	cellular communication network factor 2	Homo sapiens	17-21
19502749-2	2009	Some compounds selectively inhibit the activities of mammalian pols, and in particular, dehydroaltenusin and curcumin derivatives, such as monoacetyl-curcumin, were found to be specific inhibitors of pol alpha and pol lambda, respectively.	Curcumin	109-117	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	200-209
19594013-0	2009	[Inhibitory effect of curcumin on MMP-2 and MMP-9 expression induced by polyethylene wear particles and its mechanism].	Curcumin	22-30	matrix metallopeptidase 9	Mus musculus	44-49
19401701-4	2009	Immunoblot studies revealed increased phosphorylation of H2A.X at Ser-139 and Chk1 at Ser-280 and a decrease in DNA polymerase-beta level in curcumin-treated cells.	Curcumin	141-149	H2A.X variant histone	Homo sapiens	57-62
19401701-4	2009	Immunoblot studies revealed increased phosphorylation of H2A.X at Ser-139 and Chk1 at Ser-280 and a decrease in DNA polymerase-beta level in curcumin-treated cells.	Curcumin	141-149	DNA polymerase beta	Homo sapiens	112-131
16697971-0	2006	Induction of early apoptosis and ROS-generation activity in human gingival fibroblasts (HGF) and human submandibular gland carcinoma (HSG) cells treated with curcumin.	Curcumin	158-166	hepatocyte growth factor	Homo sapiens	88-91
16697971-1	2006	OBJECTIVE: Curcumin [1] is well known to possess apoptosis-inducing activity in some cancer cells, but little is known about its activity in normal cells of oral origin, such as HGF.	Curcumin	11-19	hepatocyte growth factor	Homo sapiens	178-181
16697971-2	2006	The aim of the present study was to clarify the relationship between early apoptosis in HGF and the induction of reactive oxygen species (ROS) generation by curcumin.	Curcumin	157-165	hepatocyte growth factor	Homo sapiens	88-91
16697971-3	2006	DESIGN: We treated HGF and HSG cells with curcumin [1] and the related compounds biseugenol [2], eugenol [3], alpha-diisoeugenol [4], and isoeugenol [5] and measured cell survival (MTT method), ROS generation (DCFH-DA staining), and induction of early apoptosis.	Curcumin	42-50	hepatocyte growth factor	Homo sapiens	19-22
16697971-7	2006	Loss of DeltaPsi(m), PS externalization and ROS generation were significantly more pronounced in HGF cells than in HSG cells at curcumin concentrations lower than about 15microM, and were inhibited by the addition of the antioxidants N-acetyl-l-cysteine and glutathione.	Curcumin	128-136	hepatocyte growth factor	Homo sapiens	97-100
16697971-8	2006	CONCLUSION: The potent PS externalization and loss of DeltaPsi(m) in curcumin-treated HGF cells appears to be mediated by ROS generation.	Curcumin	69-77	hepatocyte growth factor	Homo sapiens	86-89
16904830-2	2006	Using such changes, the average binding constants of curcumin to phosphatidylcholine (PC) liposomes and human serum albumin (HSA) were estimated to be 2.5 x 10(4) M(-1) and 6.1 x 10(4) M(-1) respectively.	Curcumin	53-61	albumin	Mus musculus	110-123
17041101-7	2006	Analysis of the effects of the analogues on the expression of cancer-related genes usually affected by curcumin indicated that some induced the down-regulation of beta-catenin, Ki-ras, cyclin D1, c-Myc, and ErbB-2 at as low as one eighth the concentration at which curcumin normally has an effect.	Curcumin	103-111	cyclin D1	Homo sapiens	185-194
16934674-6	2006	In addition, suppression of MMP-2 activity by H2O2 in a dose- and time-dependent manner in vitro is blocked by melatonin, omeprazole, and curcumin.	Curcumin	138-146	matrix metallopeptidase 2	Homo sapiens	28-33
16934674-7	2006	We observed that melatonin and other antioxidants (e.g., curcumin and omeprazole) offered gastroprotection in vivo by upregulation of suppressed MMP-2 expression and activity at the level of secretion and synthesis.	Curcumin	57-65	matrix metallopeptidase 2	Homo sapiens	145-150
16879256-8	2006	The TLR2- and TLR4-mediated response to stimulation was dependent on NF-kappaB signalling, as shown by curcumin pretreatment of TECs.	Curcumin	103-111	toll-like receptor 2	Mus musculus	4-8
16678799-5	2006	Curcumin, a polyphenol found in the plant Curcuma longa, has been shown to suppress the activation of NF-kappaB induced by various pro-inflammatory stimuli by inhibiting IKKbeta kinase activity in MyD88-dependent pathway.	Curcumin	0-8	MYD88 innate immune signal transduction adaptor	Homo sapiens	197-202
16678799-6	2006	Curcumin also inhibited LPS-induced IRF3 activation.	Curcumin	0-8	interferon regulatory factor 3	Homo sapiens	36-40
16678799-7	2006	These results imply that curcumin inhibits both MyD88- and TRIF-dependent pathways in LPS-induced TLR4 signaling.	Curcumin	25-33	MYD88 innate immune signal transduction adaptor	Homo sapiens	48-53
16804969-0	2006	Curcumin-attenuated trinitrobenzene sulphonic acid induces chronic colitis by inhibiting expression of cyclooxygenase-2.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	103-119
16804969-9	2006	Also curcumin reduced the expression of COX-2 and inflammation cytokines.	Curcumin	5-13	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	40-45
16804969-11	2006	CONCLUSION: Curcumin has therapeutic effects on TNBS acid-induced colitis, the mechanisms seem to be related to COX-2 inhibition and PGE(2) improvement.	Curcumin	12-20	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	112-117
16777101-5	2006	The anticancer agent curcumin, also inhibited G6PT gene expression by more than 90% and triggered U-87 glioma cells death.	Curcumin	21-29	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	46-50
16777101-6	2006	Overexpression of recombinant G6PT rescued the cells from curcumin-induced cell death.	Curcumin	58-66	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	30-34
16685393-3	2006	While IFN-alpha or COX-2 inhibitors alone did not result in growth inhibition of A549 cells, the combination of IFN-alpha and celecoxib or curcumin resulted in a significant growth inhibition of A549 cells, which was associated with down-regulation of CDK2, 4, and 6 and up-regulation of p27.	Curcumin	139-147	cyclin dependent kinase 2	Homo sapiens	252-256
16563357-6	2006	For instance, the cell-signaling pathways inhibited by curcumin alone include NF-kappaB, AP-1, STAT3, Akt, Bcl-2, Bcl-X(L), caspases, PARP, IKK, EGFR, HER2, JNK, MAPK, COX2, and 5-LOX.	Curcumin	55-63	cox2	Glycine max	168-172
16630125-8	2006	Curcumin reduced the expression of cell cycle regulators, cyclin D1 and c-Myc proteins, which are both degraded by activated GSK-3beta.	Curcumin	0-8	cyclin D1	Homo sapiens	58-67
16630125-8	2006	Curcumin reduced the expression of cell cycle regulators, cyclin D1 and c-Myc proteins, which are both degraded by activated GSK-3beta.	Curcumin	0-8	glycogen synthase kinase 3 beta	Homo sapiens	125-134
16545682-8	2006	Both transferrin receptor 1 and activated IRP, indicators of iron depletion, increased in response to curcumin.	Curcumin	102-110	Wnt family member 2	Homo sapiens	42-45
16294327-10	2006	Curcumin inhibited interleukin-1beta- and TNF-alpha-induced activation of activator protein-1 (AP-1) and mitogen-activated protein (MAP) kinases (ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase), but not of nuclear factor-kappaB (NF-kappaB).	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	74-93
16294327-10	2006	Curcumin inhibited interleukin-1beta- and TNF-alpha-induced activation of activator protein-1 (AP-1) and mitogen-activated protein (MAP) kinases (ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase), but not of nuclear factor-kappaB (NF-kappaB).	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	95-99
16294327-10	2006	Curcumin inhibited interleukin-1beta- and TNF-alpha-induced activation of activator protein-1 (AP-1) and mitogen-activated protein (MAP) kinases (ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase), but not of nuclear factor-kappaB (NF-kappaB).	Curcumin	0-8	mitogen activated protein kinase 14	Rattus norvegicus	186-200
16648563-0	2006	Curcumin induces caspase-3-dependent apoptotic pathway but inhibits DNA fragmentation factor 40/caspase-activated DNase endonuclease in human Jurkat cells.	Curcumin	0-8	DNA fragmentation factor subunit beta	Homo sapiens	96-119
16648563-8	2006	Instead, molecular modeling indicates that the inhibitory effect of curcumin on DFF40/CAD activity results from curcumin binding to the active center of DFF40/CAD endonuclease.	Curcumin	68-76	DNA fragmentation factor subunit beta	Homo sapiens	80-85
16648563-8	2006	Instead, molecular modeling indicates that the inhibitory effect of curcumin on DFF40/CAD activity results from curcumin binding to the active center of DFF40/CAD endonuclease.	Curcumin	68-76	DNA fragmentation factor subunit beta	Homo sapiens	153-158
16648563-8	2006	Instead, molecular modeling indicates that the inhibitory effect of curcumin on DFF40/CAD activity results from curcumin binding to the active center of DFF40/CAD endonuclease.	Curcumin	112-120	DNA fragmentation factor subunit beta	Homo sapiens	80-85
16648563-8	2006	Instead, molecular modeling indicates that the inhibitory effect of curcumin on DFF40/CAD activity results from curcumin binding to the active center of DFF40/CAD endonuclease.	Curcumin	112-120	DNA fragmentation factor subunit beta	Homo sapiens	153-158
16638200-0	2006	[Regulatory effect of curcumin on p300 and HDAC1 in B-NHL cells].	Curcumin	22-30	E1A binding protein p300	Homo sapiens	34-38
16638200-4	2006	The curcumin significantly inhibited activity and expression of p300 and HDAC1.	Curcumin	4-12	E1A binding protein p300	Homo sapiens	64-68
16638200-7	2006	Curcumin can inhibit the activity and expression of the transcriptional co-activator p300 and HDAC1, which may be involved in its pharmacological mechanisms on B lymphoma cells.	Curcumin	0-8	E1A binding protein p300	Homo sapiens	85-89
16387490-0	2006	Cyclooxygenase-2 expression and oxidative DNA adducts in murine intestinal adenomas: modification by dietary curcumin and implications for clinical trials.	Curcumin	109-117	prostaglandin-endoperoxide synthase 2	Mus musculus	0-16
16387490-2	2006	In other preclinical models, curcumin downregulates the transcription of the enzyme cyclooxygenase-2 (COX-2) and decreases levels of two oxidative DNA adducts, the pyrimidopurinone adduct of deoxyguanosine (M1dG) and 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG).	Curcumin	29-37	prostaglandin-endoperoxide synthase 2	Mus musculus	84-100
16387490-2	2006	In other preclinical models, curcumin downregulates the transcription of the enzyme cyclooxygenase-2 (COX-2) and decreases levels of two oxidative DNA adducts, the pyrimidopurinone adduct of deoxyguanosine (M1dG) and 8-oxo-7,8-dihydro-2"-deoxyguanosine (8-oxo-dG).	Curcumin	29-37	prostaglandin-endoperoxide synthase 2	Mus musculus	102-107
16106398-5	2006	Curcumin induced cell cycle arrest by reducing the expression of cyclin D1, Cdk1 and Cdc25C and apoptosis by reducing the expression of XIAP and survivin.	Curcumin	0-8	cyclin D1	Homo sapiens	65-74
16584595-4	2006	Furthermore, BDNF was detected in the MM cell and TrkB was detected in the endothelial cell and curcumin depressed the mRNA expression of BDNF and TrkB in the dose- and time-dependent manners.	Curcumin	96-104	neurotrophic receptor tyrosine kinase 2	Homo sapiens	50-54
16584595-4	2006	Furthermore, BDNF was detected in the MM cell and TrkB was detected in the endothelial cell and curcumin depressed the mRNA expression of BDNF and TrkB in the dose- and time-dependent manners.	Curcumin	96-104	neurotrophic receptor tyrosine kinase 2	Homo sapiens	147-151
16584595-6	2006	Curcumin interrupts the interaction between multiple myeloma cells and endothelial cells by reducing TrkB expression in endothelial cells and inhibiting BDNF production in multiple myeloma cells, eventually, resulting in inhibition of angiogenesis.	Curcumin	0-8	neurotrophic receptor tyrosine kinase 2	Homo sapiens	101-105
16423986-7	2006	injection of curcumin or PEITC (6 and 5 mumol; thrice a week for 28 days), beginning a day before tumor implantation significantly retarded the growth of PC-3 xenografts.	Curcumin	13-21	chromobox 8	Mus musculus	154-158
16423986-12	2006	Taken together, our results show that PEITC and curcumin alone or in combination possess significant cancer-preventive activities in the PC-3 prostate tumor xenografts.	Curcumin	48-56	chromobox 8	Mus musculus	137-141
16170359-4	2006	We recently reported that curcumin inhibited the growth of human colon cancer-derived Moser cells by suppressing gene expression of cyclinD1 and EGFR.	Curcumin	26-34	cyclin D1	Homo sapiens	132-140
16543625-6	2006	The increased NCD on day 7 and 14 were attenuated significantly by daily treatment of curcumin solution (3000 mg/kg BW).The curcumin treatment reduced the tumor-induced over-expression of COX-2 and serum VEGF in HepG2 groups significantly (p&lt;0.001), indicating that curcumin could inhibit tumor angiogenesis.	Curcumin	86-94	cytochrome c oxidase II, mitochondrial	Mus musculus	188-193
16543625-6	2006	The increased NCD on day 7 and 14 were attenuated significantly by daily treatment of curcumin solution (3000 mg/kg BW).The curcumin treatment reduced the tumor-induced over-expression of COX-2 and serum VEGF in HepG2 groups significantly (p&lt;0.001), indicating that curcumin could inhibit tumor angiogenesis.	Curcumin	124-132	cytochrome c oxidase II, mitochondrial	Mus musculus	188-193
16543625-6	2006	The increased NCD on day 7 and 14 were attenuated significantly by daily treatment of curcumin solution (3000 mg/kg BW).The curcumin treatment reduced the tumor-induced over-expression of COX-2 and serum VEGF in HepG2 groups significantly (p&lt;0.001), indicating that curcumin could inhibit tumor angiogenesis.	Curcumin	124-132	cytochrome c oxidase II, mitochondrial	Mus musculus	188-193
16219905-10	2006	We found that curcumin suppressed TNF-induced nuclear translocation of p65, which corresponded with the sequential suppression of IkappaBalpha kinase activity, IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation, p65 nuclear translocation, and p65 acetylation.	Curcumin	14-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	216-219
16219905-10	2006	We found that curcumin suppressed TNF-induced nuclear translocation of p65, which corresponded with the sequential suppression of IkappaBalpha kinase activity, IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation, p65 nuclear translocation, and p65 acetylation.	Curcumin	14-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	216-219
16219905-10	2006	We found that curcumin suppressed TNF-induced nuclear translocation of p65, which corresponded with the sequential suppression of IkappaBalpha kinase activity, IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation, p65 nuclear translocation, and p65 acetylation.	Curcumin	14-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	216-219
16173963-7	2005	BAY 11-7082- and curcumin-induced cell death was associated with downregulation of Bcl-xL, cyclin D1, XIAP and c-FLIP, followed by caspase-8, poly(ADP-ribose) polymerase cleavage and activation.	Curcumin	17-25	cyclin D1	Homo sapiens	91-100
16298737-5	2005	Rats pretreated with curcumin or naringenin showed a clear protection of the number of TH-positive cells in the SN and DA levels in the striata.	Curcumin	21-29	tyrosine hydroxylase	Rattus norvegicus	87-89
16023083-3	2005	Since MCL cells are known to overexpress NF-kappaB regulated gene products (including cyclin D1), we used curcumin, a pharmacologically safe agent, to target NF-kappaB in a variety of MCL cell lines.	Curcumin	106-114	cyclin D1	Homo sapiens	86-95
16023083-6	2005	On treatment of cells with curcumin, however, downregulated constitutive active NF-kappaB and inhibited the consitutively active IkappaBalpha kinase (IKK), and phosphorylation of IkappaBalpha and p65.	Curcumin	27-35	RELA proto-oncogene, NF-kB subunit	Homo sapiens	196-199
16046709-0	2005	Curcumin blocks interleukin-1 (IL-1) signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells.	Curcumin	0-8	interleukin-1 receptor-associated kinase 1	Mus musculus	116-120
16046709-5	2005	We asked, therefore, whether IRAK is also a target for curcumin.	Curcumin	55-63	interleukin-1 receptor-associated kinase 1	Mus musculus	29-33
16046709-6	2005	Curcumin indeed blocked IRAK thiols in a murine T-cell line stably overexpressing IRAK (EL-4(IRAK)), which resulted in the inhibition of IRAK recruitment to the IL-1RI and phosphorylation of IRAK and IL-1RI-associated proteins.	Curcumin	0-8	interleukin-1 receptor-associated kinase 1	Mus musculus	24-28
16046709-6	2005	Curcumin indeed blocked IRAK thiols in a murine T-cell line stably overexpressing IRAK (EL-4(IRAK)), which resulted in the inhibition of IRAK recruitment to the IL-1RI and phosphorylation of IRAK and IL-1RI-associated proteins.	Curcumin	0-8	interleukin-1 receptor-associated kinase 1	Mus musculus	82-86
16046709-6	2005	Curcumin indeed blocked IRAK thiols in a murine T-cell line stably overexpressing IRAK (EL-4(IRAK)), which resulted in the inhibition of IRAK recruitment to the IL-1RI and phosphorylation of IRAK and IL-1RI-associated proteins.	Curcumin	0-8	interleukin-1 receptor-associated kinase 1	Mus musculus	88-98
16046709-6	2005	Curcumin indeed blocked IRAK thiols in a murine T-cell line stably overexpressing IRAK (EL-4(IRAK)), which resulted in the inhibition of IRAK recruitment to the IL-1RI and phosphorylation of IRAK and IL-1RI-associated proteins.	Curcumin	0-8	interleukin-1 receptor-associated kinase 1	Mus musculus	82-86
16046709-6	2005	Curcumin indeed blocked IRAK thiols in a murine T-cell line stably overexpressing IRAK (EL-4(IRAK)), which resulted in the inhibition of IRAK recruitment to the IL-1RI and phosphorylation of IRAK and IL-1RI-associated proteins.	Curcumin	0-8	interleukin-1 receptor-associated kinase 1	Mus musculus	82-86
16129047-0	2005	[Effect of curcumin on caspase 8- and caspase 9- induced apoptosis of lymphoma Raji cell].	Curcumin	11-19	caspase 8	Homo sapiens	23-32
16129047-6	2005	The expressions of caspase 8 and caspase 9 in Raji cells after treatment with curcumin at 25 micromol/L (IC(50)) and for 24 hours were detected by Western blot.	Curcumin	78-86	caspase 8	Homo sapiens	19-28
16129047-10	2005	It is concluded that the expression of caspase 8 and caspase 9 plays an important role in the proliferation and apoptosis of Raji cells, so that curcumin showed inhibitive effect on Raji cells at various concentrations.	Curcumin	145-153	caspase 8	Homo sapiens	39-48
16013440-7	2005	Further, CD31 immunohistological staining of peritoneum sections in curcumin-treated mice suggests its efficacy in acting as anti-angiogenic compound in EAT cells by inhibiting proliferation of endothelial cells in mouse peritoneum.	Curcumin	68-76	platelet/endothelial cell adhesion molecule 1	Mus musculus	9-13
15615723-5	2005	The anti-inflammatory and antioxidant properties of curcumin, an active component of turmeric, suggest that curcumin may exert antiulcer activity through scavenging reactive oxygen species, by regulating MMP activity, or both.	Curcumin	52-60	matrix metallopeptidase 2	Rattus norvegicus	204-207
15615723-5	2005	The anti-inflammatory and antioxidant properties of curcumin, an active component of turmeric, suggest that curcumin may exert antiulcer activity through scavenging reactive oxygen species, by regulating MMP activity, or both.	Curcumin	108-116	matrix metallopeptidase 2	Rattus norvegicus	204-207
15486348-0	2005	Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR.	Curcumin	29-37	cyclin D1	Homo sapiens	112-121
15486348-7	2005	Activation of PPARgamma mediated curcumin suppression of the expression of cyclin D1, a critical protein in the cell cycle, in Moser cells.	Curcumin	33-41	cyclin D1	Homo sapiens	75-84
15683997-0	2005	[Effects of combined use of curcumin and catechin on cyclooxygenase-2 mRNA expression in dimethylhydrazine-induced rat colon carcinogenesis].	Curcumin	28-36	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	53-69
15683997-1	2005	OBJECTIVE: To examine the effect of combined use of curcumin and catechin on the number of aberrant crypt foci (ACF) and expression levels of cyclooxygenase-2 (COX-2) mRNA in rat colon carcinogenesis.	Curcumin	52-60	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	142-158
15683997-6	2005	A synergistic inhibitory effect between curcumin and catechin on the expression of COX-2 mRNA was observed in the early stage of rat colon carcinogenesis but not in colon tumor tissues.	Curcumin	40-48	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	83-88
15683997-7	2005	CONCLUSION: Curcumin and catechin have synergistic effect on ACF and COX-2 mRNA expression in rat colon carcinogenesis, suggesting their potential value in the prevention of human colon cancers.	Curcumin	12-20	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	69-74
15668729-6	2005	Curcumin, an inhibitor of transcription factor AP-1, blocked lithium cytoprotection against thapsigargin cytotoxicity.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	47-51
15569404-8	2004	After removal of tBHP and then further treatment with curcumin (2.5-20 micromol/L) for 18 h, curcumin abrogated Deltapsim loss and cytochrome c release, blocked activation of caspase 3, and altered the expression of Bcl-2 family.	Curcumin	54-62	caspase 3	Rattus norvegicus	175-184
15569404-8	2004	After removal of tBHP and then further treatment with curcumin (2.5-20 micromol/L) for 18 h, curcumin abrogated Deltapsim loss and cytochrome c release, blocked activation of caspase 3, and altered the expression of Bcl-2 family.	Curcumin	93-101	caspase 3	Rattus norvegicus	175-184
15451666-8	2004	Proteasome-dependent degradation of endogenous Id1 in HeLa cells is also stimulated by treatment with curcumin or emodin.	Curcumin	102-110	inhibitor of DNA binding 1, HLH protein	Homo sapiens	47-50
15205359-8	2004	Curcumin-induced activation of caspase 8 was blocked by Ku70 but not by Bcl-XL.	Curcumin	0-8	caspase 8	Homo sapiens	31-40
15205359-9	2004	However, caspase 8 activation by curcumin was accelerated in both AsBcl-XL and AsKu70 cells suggesting a possible feedback activation of caspase 8 by caspase 3.	Curcumin	33-41	caspase 8	Homo sapiens	9-18
15205359-9	2004	However, caspase 8 activation by curcumin was accelerated in both AsBcl-XL and AsKu70 cells suggesting a possible feedback activation of caspase 8 by caspase 3.	Curcumin	33-41	caspase 8	Homo sapiens	137-146
15200418-7	2004	Prolonged curcumin treatment (&gt;6 h) significantly reduced TGF-beta receptor type II levels and SMAD2/3 phosphorylation in response to added TGF-beta.	Curcumin	10-18	transforming growth factor, beta receptor 2	Rattus norvegicus	61-86
15118344-5	2004	Pretreatment of curcumin, an inhibitor of c-jun N-terminal kinase (JNK), dose-dependently suppressed the induction of Mn-SOD mRNA by YS 51, but not by 2"-amino-3"-methoxyflavone (PD98059) and 4-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-5-(4-pyridyl)imidazol (SB203580), inhibitors of mitogen-activated protein kinase.	Curcumin	16-24	superoxide dismutase 2	Homo sapiens	118-124
15095415-5	2004	We report that curcumin prevented PDT-induced JNK activation, mitochondrial release of cytochrome c, caspase-3 activation, and cleavage of PAK2.	Curcumin	15-23	p21 (RAC1) activated kinase 2	Homo sapiens	139-143
14604899-10	2004	Curcumin-induced cleavage of PARP and DFF45 was inhibited by hsp70 but enhanced in Ashsp70 cells.	Curcumin	0-8	DNA fragmentation factor subunit alpha	Homo sapiens	38-43
14557274-6	2004	Moreover, treatment of colon cells with certain diet-associated constituents, curcumin and nordihydroguaiaretic acid, reversibly targets UGTs causing inhibition without affecting protein levels; there is no direct inhibition of control UGT using curcumin as substrate in the in vitro assay.	Curcumin	78-86	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	137-140
14557274-6	2004	Moreover, treatment of colon cells with certain diet-associated constituents, curcumin and nordihydroguaiaretic acid, reversibly targets UGTs causing inhibition without affecting protein levels; there is no direct inhibition of control UGT using curcumin as substrate in the in vitro assay.	Curcumin	246-254	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	137-140
14531733-9	2004	This was further supported by the observation that curcumin suppressed both the DNA-binding activity of NF-kappaB and the induction of MnSOD mRNA in cells cultivated under metal-depleted conditions.	Curcumin	51-59	superoxide dismutase 2	Homo sapiens	135-140
19495944-1	2009	The current study reports the binding of curcumin (CUR) as the main pharmacologically active ingredient of turmeric and diacetylcurcumin (DAC) as a bioactive derivative of curcumin to human serum albumin (HSA) and bovine serum albumin (BSA).	Curcumin	41-49	arylacetamide deacetylase	Homo sapiens	138-141
19495944-1	2009	The current study reports the binding of curcumin (CUR) as the main pharmacologically active ingredient of turmeric and diacetylcurcumin (DAC) as a bioactive derivative of curcumin to human serum albumin (HSA) and bovine serum albumin (BSA).	Curcumin	128-136	arylacetamide deacetylase	Homo sapiens	138-141
19426594-1	2009	AIM: To study the effects of curcumin on TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice.	Curcumin	29-37	transforming growth factor, beta 1	Mus musculus	55-64
19426594-6	2009	Compared with sham operation group, TNF-alpha and TGF-beta1 in serum and lung tissue increased significantly(P&lt;0.01), but decreased in different degrees after treated with curcumin(P&lt;0.05).	Curcumin	175-183	transforming growth factor, beta 1	Mus musculus	50-59
19426594-7	2009	CONCLUSION: Curcumin can decrease the level of TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice and have the anti-fibrosis role by deregulating cytokine level.	Curcumin	12-20	transforming growth factor, beta 1	Mus musculus	61-70
19288022-0	2009	Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-kappaBp65 expression in breast cancer MDA-MB-231 cells.	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	98-110
19372569-4	2009	Curcumin also potentiated the apoptotic effects of thalidomide and bortezomib by down-regulating the constitutive activation of NF-kappaB and Akt, and this correlated with the suppression of NF-kappaB-regulated gene products, including cyclin D1, Bcl-xL, Bcl-2, TRAF1, cIAP-1, XIAP, survivin, and vascular endothelial growth factor.	Curcumin	0-8	cyclin D1	Homo sapiens	236-245
19372569-4	2009	Curcumin also potentiated the apoptotic effects of thalidomide and bortezomib by down-regulating the constitutive activation of NF-kappaB and Akt, and this correlated with the suppression of NF-kappaB-regulated gene products, including cyclin D1, Bcl-xL, Bcl-2, TRAF1, cIAP-1, XIAP, survivin, and vascular endothelial growth factor.	Curcumin	0-8	baculoviral IAP repeat containing 2	Homo sapiens	269-275
19781154-7	2009	The protein expressions of MMP-2 and MMP-9 were significantly down-regulated in HF group and could be significantly up-regulated by Curcumin treatment.	Curcumin	132-140	matrix metalloproteinase-9	Oryctolagus cuniculus	37-42
19121625-3	2009	The incubation of RAW264.7 cells with curcumin dose-dependently inhibited the stimulatory responses of macrophage triggered by lipopolysaccharide; the enhanced secretion of inflammatory cytokines such as TNF-alpha and IL-1beta and the up-regulated expression of surface antigens like CD14 and CD40.	Curcumin	38-46	CD14 antigen	Mus musculus	284-288
19121625-3	2009	The incubation of RAW264.7 cells with curcumin dose-dependently inhibited the stimulatory responses of macrophage triggered by lipopolysaccharide; the enhanced secretion of inflammatory cytokines such as TNF-alpha and IL-1beta and the up-regulated expression of surface antigens like CD14 and CD40.	Curcumin	38-46	CD40 antigen	Mus musculus	293-297
19121625-4	2009	Curcumin alone, however, was able to increase the basal level of TNF-alpha secretion and elevated markedly the expression of CD14 and slightly CD40.	Curcumin	0-8	CD14 antigen	Mus musculus	125-129
19121625-4	2009	Curcumin alone, however, was able to increase the basal level of TNF-alpha secretion and elevated markedly the expression of CD14 and slightly CD40.	Curcumin	0-8	CD40 antigen	Mus musculus	143-147
19121625-5	2009	The marked enhancement of both phagocytic activity and CD14 was detectable as early as 75min after curcumin treatment which is the minimum time period required for the phagocytosis and CD14 measurement, suggesting a signaling pathway distinct from that triggered by apoptotic cells.	Curcumin	99-107	CD14 antigen	Mus musculus	55-59
18495463-0	2009	Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	128-132
18495463-6	2009	Zymography analysis exhibited that curcumin, DMC and BDMC significantly decreased uPA, active-MMP-2 and MMP-9 but not pro-MMP-2 secretion from the cells in a dose-dependent manner, in which BDMC and DMC show higher potency than curcumin.	Curcumin	35-43	matrix metallopeptidase 2	Homo sapiens	94-99
19002695-12	2009	Furthermore, our data suggest that there is a significant reduction in the activity of iNOS and a rise in the expression of SP-D in lung tissue of different pulmonary aspiration models with curcumin therapy.	Curcumin	190-198	surfactant protein D	Rattus norvegicus	124-128
18794131-7	2008	Knockdown of JunD expression could partially reduce the curcumin-induced HLJ1 activation and diminish the anti-invasive effect of curcumin, indicating that JunD would seem to be involved in curcumin-induced HLJ1 expression.	Curcumin	130-138	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-17
18794131-7	2008	Knockdown of JunD expression could partially reduce the curcumin-induced HLJ1 activation and diminish the anti-invasive effect of curcumin, indicating that JunD would seem to be involved in curcumin-induced HLJ1 expression.	Curcumin	130-138	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	156-160
18794131-7	2008	Knockdown of JunD expression could partially reduce the curcumin-induced HLJ1 activation and diminish the anti-invasive effect of curcumin, indicating that JunD would seem to be involved in curcumin-induced HLJ1 expression.	Curcumin	130-138	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-17
18794131-7	2008	Knockdown of JunD expression could partially reduce the curcumin-induced HLJ1 activation and diminish the anti-invasive effect of curcumin, indicating that JunD would seem to be involved in curcumin-induced HLJ1 expression.	Curcumin	130-138	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	156-160
18794131-8	2008	Curcumin was able to induce c-Jun NH(2)-kinase (JNK) phosphorylation, whereas the JNK inhibitor (SP-600125) could attenuate curcumin-induced JunD and HLJ1 expression.	Curcumin	124-132	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	141-145
18794131-10	2008	Our results show that curcumin induces HLJ1, through activation of the JNK/JunD pathway, and inhibits lung cancer cell invasion and metastasis by modulating E-cadherin expression.	Curcumin	22-30	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-79
18640105-8	2008	Curcumin significantly decreased the expression of caspase-3 protein.	Curcumin	0-8	caspase 3	Rattus norvegicus	51-60
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Curcumin	405-413	protein kinase C delta	Homo sapiens	37-46
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Curcumin	405-413	protein kinase C delta	Homo sapiens	37-40
21479462-7	2008	We also explore the fact that curcumin in combination with anti-VEGF or anti-neuropilin (NRP)-1 antibody exhibits enhanced anti-angiogenic activity compared to curcumin alone.	Curcumin	30-38	neuropilin 1	Homo sapiens	89-95
21479462-7	2008	We also explore the fact that curcumin in combination with anti-VEGF or anti-neuropilin (NRP)-1 antibody exhibits enhanced anti-angiogenic activity compared to curcumin alone.	Curcumin	160-168	neuropilin 1	Homo sapiens	89-95
18493855-7	2008	Our studies demonstrate that curcumin triggers ER stress and the activation of specific cell death pathways that feature caspase cleavage and activation, p23 cleavage, and downregulation of the anti-apoptotic Mcl-1 protein.	Curcumin	29-37	myeloid cell leukemia sequence 1	Mus musculus	209-214
18386790-4	2008	Curcumin is incorporated into H-RS cells and acts inhibiting both NF-kappaB and STAT3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1, survivin, c-myc and cyclin D1.	Curcumin	0-8	baculoviral IAP repeat containing 2	Homo sapiens	223-229
18386790-4	2008	Curcumin is incorporated into H-RS cells and acts inhibiting both NF-kappaB and STAT3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1, survivin, c-myc and cyclin D1.	Curcumin	0-8	cyclin D1	Homo sapiens	251-260
18550174-13	2008	It may conclude that tannic acid and curcumin as a chelating agent were more effective to reduce LPO levels in Al treatments group than Pb groups.	Curcumin	37-45	lactoperoxidase	Rattus norvegicus	97-100
18588981-3	2008	Small interfering RNA (siRNA) against p65 or BAY11-7082, an inhibitor of NF-kappaB, significantly suppressed the curcumin and/or Nrf2-induced increase in expression levels and promoter activity of the AR gene.	Curcumin	113-121	RELA proto-oncogene, NF-kB subunit	Homo sapiens	38-41
18588981-4	2008	BAY11-7082 or siRNA against p65 also attenuated the curcumin-induced increase in the promoter activity of the wild type AR-ORE(wt) gene, but not that of the mutated AR-ORE(mt), indicating that the ORE is essential for the response to NF-kappaB.	Curcumin	52-60	RELA proto-oncogene, NF-kB subunit	Homo sapiens	28-31
18588981-5	2008	The expression of p65, the promoter activity and DNA binding activity of NF-kappaB were enhanced in the presence of curcumin in cells that were transfected with Nrf2 compared to those treated with curcumin alone.	Curcumin	116-124	RELA proto-oncogene, NF-kB subunit	Homo sapiens	18-21
18588981-5	2008	The expression of p65, the promoter activity and DNA binding activity of NF-kappaB were enhanced in the presence of curcumin in cells that were transfected with Nrf2 compared to those treated with curcumin alone.	Curcumin	197-205	RELA proto-oncogene, NF-kB subunit	Homo sapiens	18-21
18477648-6	2008	In contrast, though curcumin (10 mumol) alone did not alter the basal activity/levels, its pre-treatment decreased the TPA-induced translocation of PKC isozymes (alpha, beta, gamma, epsilon, eta), resulting in appropriate alterations in activity.	Curcumin	20-28	endothelin receptor type A	Mus musculus	162-194
18357586-2	2008	Herein, we show that Curcumin dose dependently induced HO-1 expression and HO-1 activity through the activation of PKCalpha, PKCdelta/ERK1/2, p38alpha, and PI3-kinase.	Curcumin	21-29	protein kinase C delta	Homo sapiens	125-133
18362141-6	2008	Inhibitors of ERKs and p38 kinases effectively blocked the mitogenic effect of curcumin in NPC.	Curcumin	79-87	mitogen-activated protein kinase 14	Mus musculus	23-26
17902169-8	2008	Moreover, S1P-induced EGFR expression was inhibited by an AP-1 inhibitor curcumin and tanshinone IIA.	Curcumin	73-81	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-62
18191976-2	2008	Curcumin is known to inhibit the histone acetyltransferase activity of the transcriptional coactivator proteins p300 and CBP, which are recruited to the immediate early (IE) gene promoters of herpes simplex virus type 1 (HSV-1) by the viral transactivator protein VP16.	Curcumin	0-8	E1A binding protein p300	Homo sapiens	112-116
18507010-7	2008	The calculated chemical hardness (eta) for curcumin was clearly smaller, whereas its electronegativity (chi) and electrophilicity (omega) were clearly greater than the corresponding values for the curcumin-related compounds tetrahydrocurcumin, isoeugenol and eugenol.	Curcumin	43-51	endothelin receptor type A	Mus musculus	34-37
18507010-8	2008	This suggested that the anti-inflammatory activities of curcumin may be related to eta-, chi- and/or omega-controlled enzymes.	Curcumin	56-64	endothelin receptor type A	Mus musculus	83-86
18292809-9	2008	From these results, we conclude that inhibition of p300 HAT activity by the nontoxic dietary compound curcumin may provide a novel therapeutic strategy for heart failure in humans.	Curcumin	102-110	E1A binding protein p300	Homo sapiens	51-59
18037917-8	2008	In this issue, Chen and co-workers propose that curcumin suppresses CTGF expression in HSC by inhibiting ERK and NF-kappaB activation.	Curcumin	48-56	cellular communication network factor 2	Homo sapiens	68-72
17927689-0	2007	Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells.	Curcumin	0-8	E1A binding protein p300	Homo sapiens	39-43
17927689-3	2007	Here, we investigate the effect of curcumin on the activation of NF-kappaB signal molecule in Raji cells to explore its relationship with HDACs or p300/CREB binding protein (CBP).	Curcumin	35-43	E1A binding protein p300	Homo sapiens	147-151
17927689-5	2007	Significant decreases in the amounts of p300, HDAC1 and HDAC3 were detected after treatment with curcumin.	Curcumin	97-105	E1A binding protein p300	Homo sapiens	40-44
17927689-5	2007	Significant decreases in the amounts of p300, HDAC1 and HDAC3 were detected after treatment with curcumin.	Curcumin	97-105	histone deacetylase 3	Homo sapiens	56-61
17927689-7	2007	The protection degradation of HDAC1 and p300 by MG-132 could be partially reversed by curcumin.	Curcumin	86-94	E1A binding protein p300	Homo sapiens	40-44
17927689-8	2007	Furthermore, curcumin could also prevent degradation of I kappaB alpha and inhibit nuclear translocation of the NF-kappaB/p65 subunit, as well as expression of Notch 1, induced by tumour necrosis factor-alpha.	Curcumin	13-21	RELA proto-oncogene, NF-kB subunit	Homo sapiens	122-125
17927689-9	2007	The results suggest that the depressive effect of curcumin on NF-kappaB signal transduction pathway may be mediated via the various components of the HDACs and p300/Notch 1 signal molecules, and may represent a new remedy for acute leukaemia.	Curcumin	50-58	E1A binding protein p300	Homo sapiens	160-164
17883952-7	2007	Moreover, curcumin suppressed NF-kappaB activation via the translocation of p65 into the nucleus.	Curcumin	10-18	RELA proto-oncogene, NF-kB subunit	Homo sapiens	76-79
17701891-0	2007	Oral curcumin mitigates the clinical and neuropathologic phenotype of the Trembler-J mouse: a potential therapy for inherited neuropathy.	Curcumin	5-13	peripheral myelin protein 22	Mus musculus	74-82
17701891-4	2007	We now show reduced apoptosis after curcumin treatment of cells in tissue culture that express PMP22 mutants.	Curcumin	36-44	peripheral myelin protein 22	Mus musculus	95-100
17701891-5	2007	Furthermore, we demonstrate that oral administration of curcumin partially mitigates the severe neuropathy phenotype of the Trembler-J mouse model in a dose-dependent manner.	Curcumin	56-64	peripheral myelin protein 22	Mus musculus	124-132
17882652-8	2007	RESULTS: Curcumin increased the inhibitory effect of gemcitabine on cell viability as well as its pro-apoptotic effect in COX-2 positive, p34 cells, but not in COX-2 negative, Panc-1 cells.	Curcumin	9-17	alpha and gamma adaptin binding protein	Homo sapiens	138-141
17882652-9	2007	In p34 cells, combination of curcumin and gemcitabine downregulated both COX-2 and p-ERK1/2 in a dose-dependent manner.	Curcumin	29-37	alpha and gamma adaptin binding protein	Homo sapiens	3-6
17532108-8	2007	The activities of kidney cortex enzymes, aminopeptidase N, angiotensinase A and dipeptidyl peptidase IV, were reduced in glycerol as well as in curcumin treated rats.	Curcumin	144-152	dipeptidylpeptidase 4	Rattus norvegicus	59-103
17617388-0	2007	Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats.	Curcumin	0-8	5-hydroxytryptamine receptor 1A	Rattus norvegicus	66-87
17617388-10	2007	In addition, curcumin significantly prevented the stress-induced decrease in 5-HT(1A) mRNA and BDNF protein levels in the hippocampal subfields, two molecules involved in hippocampal neurogenesis.	Curcumin	13-21	5-hydroxytryptamine receptor 1A	Rattus norvegicus	77-84
17617388-12	2007	Moreover, curcumin treatment, via up-regulation of 5-HT(1A) receptors and BDNF, may reverse or protect hippocampal neurons from further damage in response to chronic stress, which may underlie the therapeutic actions of curcumin.	Curcumin	10-18	5-hydroxytryptamine receptor 1A	Rattus norvegicus	51-58
17617388-12	2007	Moreover, curcumin treatment, via up-regulation of 5-HT(1A) receptors and BDNF, may reverse or protect hippocampal neurons from further damage in response to chronic stress, which may underlie the therapeutic actions of curcumin.	Curcumin	220-228	5-hydroxytryptamine receptor 1A	Rattus norvegicus	51-58
17603281-5	2007	The antiproliferative effect of curcumin in VSMCs was accompanied by the increased expression of p21(WAF1/CIP1).	Curcumin	32-40	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	101-110
17603281-6	2007	Inhibition of VSMC growth and expression of p21(WAF1/CIP1) by curcumin were partially, but not completely, abolished when the cells were co- incubated with the HO inhibitor tin protoporphyrin.	Curcumin	62-70	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	48-52
17603281-6	2007	Inhibition of VSMC growth and expression of p21(WAF1/CIP1) by curcumin were partially, but not completely, abolished when the cells were co- incubated with the HO inhibitor tin protoporphyrin.	Curcumin	62-70	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	53-57
17433521-4	2007	Curcumin inhibited CYP1A2 (IC(50), 40.0 microM), CYP3A4 (IC(50), 16.3 microM), CYP2D6 (IC(50), 50.3 microM), CYP2C9 (IC(50), 4.3 microM) and CYP2B6 (IC(50), 24.5 microM).	Curcumin	0-8	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	141-147
17433521-5	2007	Curcumin showed a competitive type of inhibition towards CYP1A2, CYP3A4 and CYP2B6, whereas a non-competitive type of inhibition was observed with respect to CYP2D6 and CYP2C9.	Curcumin	0-8	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	76-82
17289836-9	2007	Because expression of antiapoptotic Bcl-2, Bcl-xL, and X-chromosome-linked inhibitor of apoptosis protein (XIAP) is regulated by NF-kappaB, both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB.	Curcumin	145-153	keratin 6A	Homo sapiens	205-208
17650800-0	2007	[Effect of curcumin on activity of matrix metalloproteinase 2, 9 and nuclear expression of RelA in rat hepatic stellate cells by activating peroxisome proliferator-activated receptor gamma signal].	Curcumin	11-19	matrix metallopeptidase 2	Rattus norvegicus	35-61
17650800-1	2007	OBJECTIVE: To study the effect of curcumin on the activity of matrix metalloproteinases (MMPs) and nuclear expression of RelA in rat hepatic stellate cells (HSCs) by activating peroxisome proliferator-activated receptor gamma (PPARgamma) signal in vitro.	Curcumin	34-42	matrix metallopeptidase 2	Rattus norvegicus	89-93
17650800-4	2007	RESULTS: The PPARgamma expression decreased gradually with increasing of HSC activation, which was up-regulated by curcumin (P &lt; 0.01); curcumin inhibited the expression of aSMA, the production of collagen type I, and the nuclear expression of activated RelA (P &lt; 0.01), and elevated the activity of MMP2 and MMP9 significantly (P &lt; 0.01).	Curcumin	139-147	matrix metallopeptidase 2	Rattus norvegicus	306-310
17650800-6	2007	CONCLUSION: By activating PPARgamma signal transduction pathway curcumin treatment can inhibit HSC activation, increase the activity of MMP2 and MMP9 and inhibit/ interfere nuclear translocation of NFkappaB.	Curcumin	64-72	matrix metallopeptidase 2	Rattus norvegicus	136-140
17131360-5	2007	In the present study, we tested the effect of curcumin--a non-toxic anti-inflammatory reagent that inhibits p38 and NF-kappaB--on lipopolysaccharide (LPS)-induced muscle wasting in mice.	Curcumin	46-54	mitogen-activated protein kinase 14	Mus musculus	108-111
17131360-10	2007	LPS activated p38 and NF-kappaB, while inhibiting AKT; whereas, curcumin administration inhibited LPS-stimulated p38 activation, without altering the effect of LPS on NF-kappaB and AKT.	Curcumin	64-72	mitogen-activated protein kinase 14	Mus musculus	113-116
17131360-11	2007	These results indicate that curcumin is effective in blocking LPS-induced loss of muscle mass through the inhibition of p38-mediated upregulation of atrogin-1/MAFbx.	Curcumin	28-36	mitogen-activated protein kinase 14	Mus musculus	120-123
16713233-5	2007	LXRalpha expression and accumulation of mRNA of the LXRalpha target gene ABCg1 were increased at low curcumin concentrations.	Curcumin	101-109	nuclear receptor subfamily 1 group H member 3	Homo sapiens	0-8
16713233-5	2007	LXRalpha expression and accumulation of mRNA of the LXRalpha target gene ABCg1 were increased at low curcumin concentrations.	Curcumin	101-109	nuclear receptor subfamily 1 group H member 3	Homo sapiens	52-60
17380673-10	2007	The luciferase activities of AP-1 and NF-kappaB were stimulated in LS (P &lt; 0.01), the up-regulated luciferase activities were attenuated by PDTC at 25 micromol/L (NF-kappaB inhibitor) and curcumin at 20 micromol/L (AP-1 inhibitor) (P &lt; 0.01).	Curcumin	191-199	jun proto-oncogene	Mus musculus	29-33
17380673-11	2007	LS altered COX-2 mRNA abundance and protein expression were decreased in treatment with PDTC at 25 micromol/L, curcumin at 20 micromol/L (P &lt; 0.01).	Curcumin	111-119	prostaglandin-endoperoxide synthase 2	Mus musculus	11-16
17569214-1	2007	Curcumin possesses anti-inflammatory activity and is a potent inhibitor of reactive-oxygen-generating enzymes such as lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase, and inducible nitric oxide synthase (iNOS); it is an effective inducer of heme oxygenase-1.	Curcumin	0-8	xanthine dehydrogenase	Homo sapiens	147-177
17310108-5	2007	Curcumin strongly induces apoptosis in MDA-MB-231 cells in correlation with reduced activation of the survival pathway NFkappaB, as a consequence of diminished IotakappaB and p65 phosphorylation.	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	175-178
17182546-8	2007	Moreover, we show that overexpression of Akt, a target of Syk, or Bcl-x(L), a target of Akt can overcome curcumin-induced apoptosis of B lymphoma cells.	Curcumin	105-113	BCL2-like 1	Mus musculus	66-74
17438848-6	2007	The percentage of cells of active AP-1, IL-5 protein in supernatants of allergic rhinitis T lymphocytes stimulated with PMA and curcumin were significantly lower than those of allergic rhinitis T lymphocytes stimulated with PMA (P &lt; 0.01); but significantly higher than those of allergic rhinitis T lymphocytes stimulated without PMA and those of deflection of nasal septum T lymphocytes stimulated.	Curcumin	128-136	interleukin 5	Homo sapiens	40-44
17374178-10	2007	Inhibition of ERKs activation by AG126, AP-1 by curcumin, and JNKs by SP600125 could reduced the induction of cyclin D1 and CDK4, whereas inhibition of p38K by SB203580 did not show any inhibitory effects on S-HELF.	Curcumin	48-56	cyclin D1	Homo sapiens	110-119
16934299-7	2006	By analysis of inhibitory features of specific MAPK inhibitors, a series of signaling cascades including c-Jun N-terminal kinase (JNK), p38 and NF-kappaB was found to play a critical role in curcumin-mediated NO inhibition in microglial cells.	Curcumin	191-199	mitogen activated protein kinase 14	Rattus norvegicus	136-139
16805852-1	2006	To elucidate the mechanism underlying suppression by curcumin of esophageal carcinogenesis induced by NMBA, we evaluated the CYP level and mutagenic activation of environmental carcinogens, by immunoblot analyses and Ames preincubation test, respectively, and bilirubin, 4-nitrophenol and testosterone UDPGT activities in F344 rats treated with curcumin and/or NMBA.	Curcumin	53-61	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	125-128
16805852-3	2006	In contrast, gavage of 0.2% curcumin decreased esophageal CYP2B1 and 2E1 by up to 60%, compared with vehicle control.	Curcumin	28-36	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	58-72
16805852-4	2006	Similarly, intragastric treatment with 270 mg/kg curcumin decreased esophageal and gastric CYP2B1 and CYP2E1, but not in lung, kidney or intestine.	Curcumin	49-57	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	91-97
16805852-7	2006	These results show that modifying effects of curcumin on esophageal carcinogenesis can be attributed to a decrease in metabolic activation of NMBA by esophageal CYP2B1 during the initiation phase, without the contribution of metabolic activation and inactivation by liver.	Curcumin	45-53	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	161-167
16715036-16	2006	In cultured RAW 264.7 cells, curcumin inhibited endotoxin-induced increases in TNF-alpha expression and markedly up-regulated PPAR-gamma expression without affecting cell viability.	Curcumin	29-37	peroxisome proliferator activated receptor gamma	Mus musculus	126-136
16849521-9	2006	Inhibition of survivin expression with small interfering RNA exhibited similar mitotic disturbances, thus implicating survivin as a major, albeit not the only, target for curcumin action.	Curcumin	171-179	baculoviral IAP repeat-containing 5	Mus musculus	118-126
16497702-0	2006	Overexpression of p65/RelA potentiates curcumin-induced apoptosis in HCT116 human colon cancer cells.	Curcumin	39-47	RELA proto-oncogene, NF-kB subunit	Homo sapiens	18-21
16497702-0	2006	Overexpression of p65/RelA potentiates curcumin-induced apoptosis in HCT116 human colon cancer cells.	Curcumin	39-47	RELA proto-oncogene, NF-kB subunit	Homo sapiens	22-26
16497702-6	2006	Indeed, overexpression of p65 enhanced curcumin-mediated apoptosis as assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) assay and poly(ADP-ribose) polymerase (PARP) cleavage.	Curcumin	39-47	RELA proto-oncogene, NF-kB subunit	Homo sapiens	26-29
16497702-7	2006	This potentiating effect of p65 upon curcumin-mediated apoptosis was reversed by transfection of cells with an IkappaB super-repressor (DeltaNIkappaB).	Curcumin	37-45	RELA proto-oncogene, NF-kB subunit	Homo sapiens	28-31
16497702-8	2006	Curcumin treatment inhibited expression of NFkappaB anti-apoptotic target genes in mock-transfected and in p65-overexpressing HCT116 cells, although expression levels remained higher in the latter.	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	107-110
16460683-0	2006	Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes.	Curcumin	34-42	protein kinase C delta	Homo sapiens	8-30
16460683-3	2006	This study examined the role of PKC in ARE-mediated gene regulation in human monocytes by curcumin, a potent inducer of the Nrf2/ARE pathway.	Curcumin	90-98	protein kinase C delta	Homo sapiens	32-35
16460683-5	2006	Curcumin also rapidly stimulated PKC phosphorylation and Ro-31-8220, a pan-PKC inhibitor, decreased curcumin-induced GCLM and HO-1 mRNA expression and ARE binding.	Curcumin	0-8	protein kinase C delta	Homo sapiens	33-36
16460683-5	2006	Curcumin also rapidly stimulated PKC phosphorylation and Ro-31-8220, a pan-PKC inhibitor, decreased curcumin-induced GCLM and HO-1 mRNA expression and ARE binding.	Curcumin	100-108	protein kinase C delta	Homo sapiens	75-78
16460683-6	2006	Rottlerin (a PKC delta inhibitor) and PKC delta antisense oligonucleotides significantly inhibited curcumin-induced GCLM and HO-1 mRNA expression and ARE binding.	Curcumin	99-107	protein kinase C delta	Homo sapiens	13-22
16460683-6	2006	Rottlerin (a PKC delta inhibitor) and PKC delta antisense oligonucleotides significantly inhibited curcumin-induced GCLM and HO-1 mRNA expression and ARE binding.	Curcumin	99-107	protein kinase C delta	Homo sapiens	38-47
16460683-8	2006	In summary, curcumin activates ARE-mediated gene expression in human monocytes via PKC delta, upstream of p38 and Nrf2.	Curcumin	12-20	protein kinase C delta	Homo sapiens	83-92
16157375-4	2006	Curcumin suppressed the constitutive AP-1 DNA-binding and transcriptional activity in HTLV-1-infected T-cell line.	Curcumin	0-8	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-41
16157375-5	2006	Curcumin also inhibited HTLV-1 Tax-induced AP-1 transcriptional activity.	Curcumin	0-8	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	43-47
16157375-7	2006	The expression of JunD was suppressed by curcumin treatment.	Curcumin	41-49	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-22
16157375-9	2006	Our results suggest that suppression of the constitutively active AP-1 by curcumin is due to, at least in-part, reducing the expression of JunD by curcumin.	Curcumin	74-82	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-70
16157375-9	2006	Our results suggest that suppression of the constitutively active AP-1 by curcumin is due to, at least in-part, reducing the expression of JunD by curcumin.	Curcumin	74-82	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	139-143
16157375-9	2006	Our results suggest that suppression of the constitutively active AP-1 by curcumin is due to, at least in-part, reducing the expression of JunD by curcumin.	Curcumin	147-155	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-70
16157375-9	2006	Our results suggest that suppression of the constitutively active AP-1 by curcumin is due to, at least in-part, reducing the expression of JunD by curcumin.	Curcumin	147-155	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	139-143
16157375-10	2006	Inhibition of AP-1 activity by curcumin may be one of the mechanisms responsible for the anti-ATL effect of curcumin.	Curcumin	31-39	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-18
16157375-10	2006	Inhibition of AP-1 activity by curcumin may be one of the mechanisms responsible for the anti-ATL effect of curcumin.	Curcumin	108-116	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-18
16787365-0	2006	Curcumin is an inhibitor of p300 histone acetylatransferase.	Curcumin	0-8	E1A binding protein p300	Homo sapiens	28-32
16787365-4	2006	In cells, curcumin promoted proteasome-dependent degradation of p300 and the closely related CBP protein without affecting the HATs PCAF or GCN5.	Curcumin	10-18	E1A binding protein p300	Homo sapiens	64-68
14637278-3	2003	In the present study, the effect of curcumin on PAR2- and PAR4-mediated HMC-1 activation was examined.	Curcumin	36-44	F2R like trypsin receptor 1	Homo sapiens	48-52
14637278-3	2003	In the present study, the effect of curcumin on PAR2- and PAR4-mediated HMC-1 activation was examined.	Curcumin	36-44	Prader Willi/Angelman region RNA 4	Homo sapiens	58-62
14637278-13	2003	CONCLUSION: Curcumin inhibits PAR2- and PAR4-mediated human mast cell activation, not by inhibition of trypsin activity but by block of ERK pathway.	Curcumin	12-20	F2R like trypsin receptor 1	Homo sapiens	30-34
14637278-13	2003	CONCLUSION: Curcumin inhibits PAR2- and PAR4-mediated human mast cell activation, not by inhibition of trypsin activity but by block of ERK pathway.	Curcumin	12-20	Prader Willi/Angelman region RNA 4	Homo sapiens	40-44
14557382-4	2003	Injection of curcumin significantly inhibited the rapid transcriptional suppression of CYP2E1, and blocked that of CYP3A2.	Curcumin	13-21	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	115-121
14642080-8	2003	Curcumin inhibits the expression of ER downstream genes including pS2 and TGF-alpha (transforming growth factor-alpha) in ER-positive MCF-7 cells, and this inhibition is also dependent on the presence of estrogen.	Curcumin	0-8	transforming growth factor alpha	Homo sapiens	74-83
14500688-7	2003	Compared with AG490, a well-characterized Janus kinase 2 inhibitor, curcumin was a more rapid (30 min vs 8 h) and more potent (10 micro M vs 100 micro M) inhibitor of STAT3 phosphorylation.	Curcumin	68-76	Janus kinase 2	Homo sapiens	42-56
12844482-0	2003	Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	54-70
12844482-4	2003	In the present work, we assessed the effects of curcumin on 12-O- tetradecanoylphorbol-13-acetate (TPA)-induced expression of cyclooxygenase-2 (COX-2) in female ICR mouse skin.	Curcumin	48-56	prostaglandin-endoperoxide synthase 2	Mus musculus	126-142
12844482-4	2003	In the present work, we assessed the effects of curcumin on 12-O- tetradecanoylphorbol-13-acetate (TPA)-induced expression of cyclooxygenase-2 (COX-2) in female ICR mouse skin.	Curcumin	48-56	prostaglandin-endoperoxide synthase 2	Mus musculus	144-149
12844482-6	2003	When applied topically onto shaven backs of mice 30 min prior to TPA, curcumin inhibited the expression of COX-2 protein in a dose-related manner.	Curcumin	70-78	prostaglandin-endoperoxide synthase 2	Mus musculus	107-112
12844482-7	2003	Immunohistochemical analysis of TPA-treated mouse skin revealed enhanced expression of COX-2 localized primarily in epidermal layer, which was markedly suppressed by curcumin pre-treatment.	Curcumin	166-174	prostaglandin-endoperoxide synthase 2	Mus musculus	87-92
12844482-12	2003	Curcumin inhibited the catalytic activity of ERK1/2 in mouse skin.	Curcumin	0-8	mitogen-activated protein kinase 3	Mus musculus	45-51
12954328-0	2003	Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin.	Curcumin	77-85	alanyl aminopeptidase, membrane	Homo sapiens	27-31
12954328-0	2003	Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin.	Curcumin	77-85	alanyl aminopeptidase, membrane	Homo sapiens	32-48
12954328-2	2003	Here, we show that curcumin, a phenolic natural product, binds to APN and irreversibly inhibits its activity.	Curcumin	19-27	alanyl aminopeptidase, membrane	Homo sapiens	66-69
12954328-3	2003	The direct interaction between curcumin with APN was confirmed both in vitro and in vivo by surface plasmon resonance analysis and an APN-specific antibody competition assay, respectively.	Curcumin	31-39	alanyl aminopeptidase, membrane	Homo sapiens	45-48
12954328-3	2003	The direct interaction between curcumin with APN was confirmed both in vitro and in vivo by surface plasmon resonance analysis and an APN-specific antibody competition assay, respectively.	Curcumin	31-39	alanyl aminopeptidase, membrane	Homo sapiens	134-137
12954328-4	2003	Moreover, curcumin and other known APN inhibitors strongly inhibited APN-positive tumor cell invasion and basic fibroblast growth factor-induced angiogenesis.	Curcumin	10-18	alanyl aminopeptidase, membrane	Homo sapiens	35-38
12954328-4	2003	Moreover, curcumin and other known APN inhibitors strongly inhibited APN-positive tumor cell invasion and basic fibroblast growth factor-induced angiogenesis.	Curcumin	10-18	alanyl aminopeptidase, membrane	Homo sapiens	69-72
12957788-7	2003	Curcumin, a JNK/AP-1 inhibitor, partially abolished the effect of IL-1beta on ATPase expression but did not interfere with the effect of PGE2.	Curcumin	0-8	dynein axonemal heavy chain 8	Homo sapiens	78-84
16787365-5	2006	In addition to inducing p300 degradation curcumin inhibited the acetyltransferase activity of purified p300 as assessed using either histone H3 or p53 as substrate.	Curcumin	41-49	E1A binding protein p300	Homo sapiens	24-28
16787365-5	2006	In addition to inducing p300 degradation curcumin inhibited the acetyltransferase activity of purified p300 as assessed using either histone H3 or p53 as substrate.	Curcumin	41-49	E1A binding protein p300	Homo sapiens	103-107
16787365-6	2006	Radiolabeled curcumin formed a covalent association with p300, and tetrahydrocurcumin displayed no p300 inhibitory activity, consistent with a Michael reaction-dependent mechanism.	Curcumin	13-21	E1A binding protein p300	Homo sapiens	57-61
16787365-8	2006	These data thus identify the medicinal natural product curcumin as a novel lead compound for development of possibly therapeutic, p300/CBP-specific HAT inhibitors.	Curcumin	55-63	E1A binding protein p300	Homo sapiens	130-134
16387490-7	2006	Lifetime administration of curcumin reduced COX-2 expression by 66% (P = 0.01), 8-oxo-dG levels by 24% (P &lt; 0.05) and M1dG levels by 39% (P &lt; 0.005).	Curcumin	27-35	prostaglandin-endoperoxide synthase 2	Mus musculus	44-49
16387490-11	2006	The effects of long-term dietary curcumin on COX-2 protein levels appear to reflect retardation of adenoma development.	Curcumin	33-41	prostaglandin-endoperoxide synthase 2	Mus musculus	45-50
24671632-5	2014	Curcumin significantly induced the transcription of peroxisome proliferator-activated receptor (PPAR) gamma and mitochondrial transcription factor A (TFAM) in APOE3, but not in APOE4 mice.	Curcumin	0-8	transcription factor A, mitochondrial	Mus musculus	150-154
16461119-2	2006	We also tested whether inhibition of nuclear factor kappa-B (NF-kappaB) and activator protein-1 (AP-1) by curcumin is involved in these mechanisms.	Curcumin	106-114	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	76-95
16461119-2	2006	We also tested whether inhibition of nuclear factor kappa-B (NF-kappaB) and activator protein-1 (AP-1) by curcumin is involved in these mechanisms.	Curcumin	106-114	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	97-101
24604218-9	2014	The curcumin- or EF-24-induced apoptosis in the Saos2 cells was mediated by the expression of Fas and activation of caspase-8, caspase-3 and poly(ADP-ribose) polymerase.	Curcumin	4-12	caspase 8	Homo sapiens	116-125
12393461-2	2003	We found that NF-kappaB was constitutively active in all human MM cell lines examined and that curcumin, a chemopreventive agent, down-regulated NF-kappaB in all cell lines as indicated by electrophoretic mobility gel shift assay and prevented the nuclear retention of p65 as shown by immunocytochemistry.	Curcumin	95-103	RELA proto-oncogene, NF-kB subunit	Homo sapiens	269-272
24534491-0	2014	Curcumin regulates delta-like homolog 1 expression in activated hepatic stellate cell.	Curcumin	0-8	delta like non-canonical Notch ligand 1	Rattus norvegicus	19-39
12393461-5	2003	Curcumin also down-regulated the expression of NF-kappaB-regulated gene products, including IkappaBalpha, Bcl-2, Bcl-x(L), cyclin D1, and interleukin-6.	Curcumin	0-8	cyclin D1	Homo sapiens	123-132
12130649-9	2002	Specific inhibitors of ERK1/2 activation (PD98059 and U0126), as well as JNK inhibitors (curcumin and dicumarol) antagonized the inhibitory effects of TGF-beta on ALP activity and mineralization, whereas the specific inhibitor of p38 MAPK (SB203580) did not affect them.	Curcumin	89-97	transforming growth factor, beta 1	Mus musculus	151-159
12130649-10	2002	PD98059 and curcumin enhanced Smad3-induced ALP activity and mineralization, whereas SB203580 inhibited them.	Curcumin	12-20	SMAD family member 3	Mus musculus	30-35
12130649-11	2002	In the luciferase reporter assay using 3TP-lux with the specific Smad3-responsive element, PD98059, and curcumin enhanced TGF-beta- and Smad3-induced transcriptional activity in MC3T3-E1 cells.	Curcumin	104-112	SMAD family member 3	Mus musculus	65-70
16125882-8	2006	Inhibition of ERKs activation by AG126, JNK by SP600125, and AP-1 by curcumin could reduced the induction of cyclin D1 and CDK4.	Curcumin	69-77	cyclin D1	Homo sapiens	109-118
16125882-8	2006	Inhibition of ERKs activation by AG126, JNK by SP600125, and AP-1 by curcumin could reduced the induction of cyclin D1 and CDK4.	Curcumin	69-77	cyclin dependent kinase 4	Homo sapiens	123-127
16951739-5	2006	RESULTS: Curcumin decreased cell viability, activated caspase-3 and decreased the level of DFF45/ICAD, the inhibitor of the DFF40/CAD endonuclease.	Curcumin	9-17	DNA fragmentation factor subunit alpha	Homo sapiens	91-96
16951739-5	2006	RESULTS: Curcumin decreased cell viability, activated caspase-3 and decreased the level of DFF45/ICAD, the inhibitor of the DFF40/CAD endonuclease.	Curcumin	9-17	DNA fragmentation factor subunit alpha	Homo sapiens	97-101
16951739-5	2006	RESULTS: Curcumin decreased cell viability, activated caspase-3 and decreased the level of DFF45/ICAD, the inhibitor of the DFF40/CAD endonuclease.	Curcumin	9-17	DNA fragmentation factor subunit beta	Homo sapiens	124-129
12130649-11	2002	In the luciferase reporter assay using 3TP-lux with the specific Smad3-responsive element, PD98059, and curcumin enhanced TGF-beta- and Smad3-induced transcriptional activity in MC3T3-E1 cells.	Curcumin	104-112	transforming growth factor, beta 1	Mus musculus	122-130
12130649-11	2002	In the luciferase reporter assay using 3TP-lux with the specific Smad3-responsive element, PD98059, and curcumin enhanced TGF-beta- and Smad3-induced transcriptional activity in MC3T3-E1 cells.	Curcumin	104-112	SMAD family member 3	Mus musculus	136-141
12216086-9	2002	The investigation of expression in IL-8 receptors, CXCR1 and CXCR2, revealed that the expression of both receptors was enhanced remarkably by curcumin.	Curcumin	142-150	C-X-C motif chemokine receptor 2	Homo sapiens	61-66
16309625-11	2005	Interestingly, feeding of curcumin, a dietary antioxidant, to diabetic rats attenuated the enhanced expression of alphaB-crystallin.	Curcumin	26-34	crystallin, alpha B	Rattus norvegicus	114-131
24534491-4	2014	The present study was aimed to elucidate the effect of curcumin on DLK1 expression in HSCs in vitro and in vivo, which is still unknown.	Curcumin	55-63	delta like non-canonical Notch ligand 1	Rattus norvegicus	67-71
16313712-6	2005	RESULTS: Compared with other recombinant pSUPER-EGFP vectors (R-pSUPER.EGFP), R-pSUPER.EGFP2 induced the best silencing effect on the expression of PPARgamma in RAW264.7 cells, which played an obvious inhibitory role in down-regulating the TNFalphaexpression after the curcumin and lipopolysaccharide (LPS) stimulation.	Curcumin	269-277	peroxisome proliferator activated receptor gamma	Mus musculus	148-157
24534491-5	2014	Our results demonstrated that curcumin reduced DLK1 expression in culture-activated HSCs and in rat model of liver fibrosis.	Curcumin	30-38	delta like non-canonical Notch ligand 1	Rattus norvegicus	47-51
24534491-6	2014	The inhibitory effect of curcumin on DLK1 expression may be mediated in part by interruption of Shh signaling pathway, which contributes to the promotion effect of curcumin on the expression of PPAR-gamma, a key factor in inhibiting HSC activation.	Curcumin	25-33	delta like non-canonical Notch ligand 1	Rattus norvegicus	37-41
24534491-6	2014	The inhibitory effect of curcumin on DLK1 expression may be mediated in part by interruption of Shh signaling pathway, which contributes to the promotion effect of curcumin on the expression of PPAR-gamma, a key factor in inhibiting HSC activation.	Curcumin	164-172	delta like non-canonical Notch ligand 1	Rattus norvegicus	37-41
11967955-0	2002	Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1/CIP1) and C/EBPbeta expressions and suppressing NF-kappaB activation.	Curcumin	0-8	CCAAT enhancer binding protein beta	Homo sapiens	114-123
24486572-6	2014	Moreover, ET-1-induced CTGF expression was significantly reduced by JNK inhibitor (SP600125), the dominant-negative mutants of JNK1/2 (JNK1/2 DN), and AP-1 inhibitor (curcumin).	Curcumin	167-175	cellular communication network factor 2	Homo sapiens	23-27
16198311-4	2005	Curcumin repressed the DNA binding and transcriptional activities of AP-1, which is a common upstream modulator of MMP-1, -3, and -9 gene expression.	Curcumin	0-8	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	69-73
16198311-6	2005	This suggests that the inhibition of MMP transcriptions by curcumin is mediated at least in part through the AP-1 and MAP kinase pathways.	Curcumin	59-67	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	109-113
24918078-5	2014	The effect of curcumin on intracellular pH (pHi) was measured by the fluorescent pH indicator 2,7-bicarboxyethyl-5,6-carboxyfluorescein-acetoxymethyl ester (BCECF-AM).	Curcumin	14-22	glucose-6-phosphate isomerase	Homo sapiens	44-47
16299251-6	2005	Surprisingly, 15-deoxy-Delta12,14-prostaglandin J(2) and the IkappaB kinase inhibitor curcumin both reduced nuclear levels of p65 in cell lines lacking IkappaBalpha, suggesting that inhibition of nuclear translocation of NF-kappaB can occur in the absence of IkappaBalpha.	Curcumin	86-94	RELA proto-oncogene, NF-kB subunit	Homo sapiens	126-129
16309195-12	2005	Curcumin, but not a-diisoeugenol, at 10 microM inhibited LPS (lipopolysaccharide)-induced COX-2 gene expression in RAW 264.7 cells.	Curcumin	0-8	cytochrome c oxidase II, mitochondrial	Mus musculus	90-95
16507392-9	2005	RESULTS: In P-34 cells, curcumin synergistically potentiated the inhibitory effect of celecoxib on cell growth.	Curcumin	24-32	alpha and gamma adaptin binding protein	Homo sapiens	12-16
15870875-0	2005	Curcumin decreases cell proliferation rates through BTG2-mediated cyclin D1 down-regulation in U937 cells.	Curcumin	0-8	cyclin D1	Homo sapiens	66-75
15870875-2	2005	It has been reported that curcumin-treated cells show decreased expression of cyclin D1, ultimately resulting in decreased cell growth rate.	Curcumin	26-34	cyclin D1	Homo sapiens	78-87
12126654-0	2002	Relative contribution of NF-kappaB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytes.	Curcumin	65-73	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-43
12025512-3	2002	Voltammetric tests, combined with coulometric and spectrophotometric measurements, pointed out that each mol of curcumin is able to react with six mols of such anion radical, through a process initiated by an acid-base step, which provides the perhydroxyl radical, HO2.	Curcumin	112-120	heme oxygenase 2	Homo sapiens	265-268
15870875-4	2005	However, the precise molecular mechanisms involving down-regulation of cyclin D1 by curcumin are not largely understood.	Curcumin	84-92	cyclin D1	Homo sapiens	71-80
24918078-11	2014	This is the first study to our knowledge which examined the effect of curcumin on sperm pHi and membrane polarization that affect sperm forward motility.	Curcumin	70-78	glucose-6-phosphate isomerase	Homo sapiens	88-91
15870875-5	2005	In this study we investigated the mechanisms of cyclin D1 down-regulation by curcumin in U937 cells.	Curcumin	77-85	cyclin D1	Homo sapiens	48-57
15870875-6	2005	Expressions of cyclin D1, particularly at protein and mRNA levels, were clearly decreased in curcumin-treated cells.	Curcumin	93-101	cyclin D1	Homo sapiens	15-24
11815407-12	2002	Curcumin was sulfated by human phenol sulfotransferase isoenzymes SULT1A1 and SULT1A3.	Curcumin	0-8	sulfotransferase family 1A member 1	Homo sapiens	66-73
24288129-5	2014	Curcumin stimulated the release of cholesterol and the lysosomal beta-hexosaminidase enzyme, as well as the exosome markers, flotillin-2 and CD63.	Curcumin	0-8	O-GlcNAcase	Homo sapiens	65-84
11716543-0	2001	Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53.	Curcumin	0-8	caspase 8	Homo sapiens	74-83
11733029-7	2001	Experiments with fluorescein 5"-isothiocyanate (FITC)-labelled ATPase also suggest that curcumin stabilizes the E1 conformational state.	Curcumin	88-96	dynein axonemal heavy chain 8	Homo sapiens	63-69
11733029-8	2001	The fact that FITC labels the nucleotide binding site of the ATPase (precluding ATP from binding), and the fact that curcumin affects FITC fluorescence indicate that curcumin must be binding to another site within the ATPase that induces a conformational change to prevent ATP from binding.	Curcumin	166-174	dynein axonemal heavy chain 8	Homo sapiens	61-67
11733029-8	2001	The fact that FITC labels the nucleotide binding site of the ATPase (precluding ATP from binding), and the fact that curcumin affects FITC fluorescence indicate that curcumin must be binding to another site within the ATPase that induces a conformational change to prevent ATP from binding.	Curcumin	166-174	dynein axonemal heavy chain 8	Homo sapiens	218-224
15870875-8	2005	Treatment of curcumin increased expression of BTG2 mRNA, a member of anti-proliferative gene family and a negative transcriptional regulator of cyclin D1.	Curcumin	13-21	cyclin D1	Homo sapiens	144-153
15870875-11	2005	Treatment of curcumin inhibited nuclear translocation of p65 NF-kappaB.	Curcumin	13-21	RELA proto-oncogene, NF-kB subunit	Homo sapiens	57-60
15870875-12	2005	Moreover, the expression of cyclin D1 mRNA was dramatically decreased after co-treatment curcumin with NF-kappaB inhibitors.	Curcumin	89-97	cyclin D1	Homo sapiens	28-37
15870875-13	2005	The data presented here indicate that curcumin-induced down-regulation of cyclin D1 mRNA is mediated by induction of BTG2 as well as inhibition of nuclear translocation of NF-kappaB.	Curcumin	38-46	cyclin D1	Homo sapiens	74-83
15738001-0	2005	Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner.	Curcumin	0-8	cyclin D1	Homo sapiens	54-63
15738001-2	2005	In asynchronous cultures, with time-lapse video-micrography in combination with quantitative fluorescence microscopy, we have demonstrated that curcumin induces apoptosis at G(2) phase of cell cycle in deregulated cyclin D1-expressed mammary epithelial carcinoma cells, leaving its normal counterpart unaffected.	Curcumin	144-152	cyclin D1	Homo sapiens	214-223
15738001-5	2005	On the other hand, curcumin reversibly inhibits normal mammary epithelial cell cycle progression by down-regulating cyclin D1 expression and blocking its association with Cdk4/Cdk6 as well as by inhibiting phosphorylation and inactivation of retinoblastoma protein.	Curcumin	19-27	cyclin D1	Homo sapiens	116-125
15738001-5	2005	On the other hand, curcumin reversibly inhibits normal mammary epithelial cell cycle progression by down-regulating cyclin D1 expression and blocking its association with Cdk4/Cdk6 as well as by inhibiting phosphorylation and inactivation of retinoblastoma protein.	Curcumin	19-27	cyclin dependent kinase 4	Homo sapiens	171-175
15738001-9	2005	Similarly, in ectopically overexpressed system, curcumin cannot down-regulate cyclin D1 and thus block cell cycle progression.	Curcumin	48-56	cyclin D1	Homo sapiens	78-87
15842781-7	2005	The expression levels of HDAC1, HDAC3, and HDAC8 proteins were downregulated following curcumin treatment in Raji cells, whereas Ac-histone H4 protein expression was upregulated after treatment with curcumin.	Curcumin	87-95	histone deacetylase 3	Homo sapiens	32-37
15842781-8	2005	CONCLUSION: Curcumin, as a new member of the histone deacetylase inhibitors, can inhibit the expression of class I HDACs (HDAC1, HDAC3, and HDAC8), and can increase the expression of Ac-histone H4 in Raji cells.	Curcumin	12-20	histone deacetylase 3	Homo sapiens	129-134
24741455-11	2014	Additionally, curcumin inhibited docetaxel-induced p65 activation and COX-2 expression.	Curcumin	14-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	51-54
24716415-0	2014	Curcumin induces apoptosis via simultaneously targeting AKT/mTOR and RAF/MEK/ERK survival signaling pathways in human leukemia THP-1 cells.	Curcumin	0-8	zinc fingers and homeoboxes 2	Homo sapiens	69-72
11700423-11	2001	The role of heat shock factor-1 in curcumin-mediated expression of heat shock protein 70 was tested in embryonic fibroblasts derived from heat shock factor-1 knockout mice.	Curcumin	35-43	heat shock factor 1	Mus musculus	12-31
24716415-7	2014	Curcumin significantly inhibited the activations of AKT/mTOR and RAF/MEK/ERK signaling pathways simultaneously.	Curcumin	0-8	zinc fingers and homeoboxes 2	Homo sapiens	65-68
11700423-11	2001	The role of heat shock factor-1 in curcumin-mediated expression of heat shock protein 70 was tested in embryonic fibroblasts derived from heat shock factor-1 knockout mice.	Curcumin	35-43	heat shock factor 1	Mus musculus	138-157
11700423-15	2001	Curcumin induced specific nuclear translocation and activation of heat shock factor-1.	Curcumin	0-8	heat shock factor 1	Mus musculus	66-85
24716415-8	2014	CONCLUSION: This study demonstrates that curcumin inhibits proliferation and induces apoptosis in THP-1 cells via inhibiting the activations of AKT/mTOR and RAF/MEK/ERK signaling pathways simultaneously.	Curcumin	41-49	zinc fingers and homeoboxes 2	Homo sapiens	157-160
11700423-16	2001	Curcumin-mediated expression of heat shock protein 70 was reduced substantially in fibroblasts having genetic ablation of heat shock factor-1.	Curcumin	0-8	heat shock factor 1	Mus musculus	122-141
16036795-7	2005	Up-regulation of COX-2 and the above ER signaling factors was reversed by treatment of the infected cells with curcumin which specifically inhibits the JNK/c-Jun pathway.	Curcumin	111-119	prostaglandin-endoperoxide synthase 2	Mus musculus	17-22
25016873-0	2014	[Effect of curcumine on the expression of Fas/FasL in rat brain tissue under chronic low O2 and high CO2].	Curcumin	11-20	Fas ligand	Rattus norvegicus	46-50
16036795-7	2005	Up-regulation of COX-2 and the above ER signaling factors was reversed by treatment of the infected cells with curcumin which specifically inhibits the JNK/c-Jun pathway.	Curcumin	111-119	jun proto-oncogene	Mus musculus	156-161
11755008-7	2001	In a second group of middle-aged female SD rats, 500 ppm dietary curcumin prevented Abeta-infusion induced spatial memory deficits in the Morris Water Maze and post-synaptic density (PSD)-95 loss and reduced Abeta deposits.	Curcumin	65-73	discs large MAGUK scaffold protein 4	Rattus norvegicus	160-190
24380633-6	2014	C6-curcumin liposomes induced G2/M arrest and showed a combined effect in the expression levels of cyclin D1 and cyclin B1.	Curcumin	3-11	cyclin D1	Homo sapiens	99-108
11457715-6	2001	Activation of activator protein-1 (AP-1) was necessary, as shown by the inhibitory effect of curcumin and the results of the gel-shift assay.	Curcumin	93-101	jun proto-oncogene	Mus musculus	14-33
11457715-6	2001	Activation of activator protein-1 (AP-1) was necessary, as shown by the inhibitory effect of curcumin and the results of the gel-shift assay.	Curcumin	93-101	jun proto-oncogene	Mus musculus	35-39
15746179-7	2005	In contrast, atrogin1/MAFbx up-regulation and the associated increase in ubiquitin conjugating activity were both blunted by p38 inhibitors, either SB203580 or curcumin.	Curcumin	160-168	mitogen-activated protein kinase 14	Mus musculus	125-128
24445042-6	2014	Meanwhile, we demonstrated that the suppression of invasiveness correlated with inhibition of Rac1/PAK1 signaling pathways and matrix metalloproteinase (MMP) 2 and 9 protein expression by combining curcumin treatment with the methods of Rac1 gene silence and overexpression in lung cancer cells.	Curcumin	198-206	p21 (RAC1) activated kinase 1	Homo sapiens	99-103
11534770-3	2001	Here, we show that curcumin inhibits H-ras-induced invasive phenotype in MCF10A human breast epithelial cells (H-ras MCF10A) and downregulates matrix metalloproteinase (MMP)-2 dose-dependently.	Curcumin	19-27	matrix metallopeptidase 2	Homo sapiens	143-175
11396178-4	2001	Investigation of cyclin-dependent kinases, Cdk2 and Cdc2, showed activity of Cdc2, but not Cdk2, increased markedly in response to curcumin.	Curcumin	131-139	cyclin dependent kinase 2	Homo sapiens	43-47
11396178-5	2001	In both cell lines, immunoblot analysis indicated that curcumin caused induction of apoptosis as evidenced by cleavage of PARP, caspase-3, and reduction in Bcl-XL levels.	Curcumin	55-63	collagen type XI alpha 2 chain	Homo sapiens	122-126
15713895-0	2005	Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin.	Curcumin	124-132	transcription factor 3	Homo sapiens	48-70
24445042-6	2014	Meanwhile, we demonstrated that the suppression of invasiveness correlated with inhibition of Rac1/PAK1 signaling pathways and matrix metalloproteinase (MMP) 2 and 9 protein expression by combining curcumin treatment with the methods of Rac1 gene silence and overexpression in lung cancer cells.	Curcumin	198-206	matrix metallopeptidase 2	Homo sapiens	127-165
18095109-3	2005	In addition, we examined the in vitro effects of antisense oligonucleotides and curcumin on the expression and activation of RelA/NF-kappaB, urokinase-type plasminogen activator (u-PA) expression, migration, and invasion in the T98G glioma cell line.	Curcumin	80-88	RELA proto-oncogene, NF-kB subunit	Homo sapiens	125-129
11396178-6	2001	Curcumin also stimulated the activity of caspase-8, which initiates Fas signalling pathway of apoptosis.	Curcumin	0-8	caspase 8	Homo sapiens	41-50
11207308-8	2001	Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.	Curcumin	11-19	Janus kinase 2	Homo sapiens	212-216
11207308-8	2001	Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.	Curcumin	21-38	Janus kinase 2	Homo sapiens	212-216
18095109-6	2005	Moreover, antisense oligonucleotides and curcumin inhibited phorbol-12-myristate-13-acetate (PMA)-induced RelA/NF-kappaB expression or activation (or both), down-regulated u-PA expression, and reduced the migration and invasive potentials of T98G glioma cells.	Curcumin	41-49	RELA proto-oncogene, NF-kB subunit	Homo sapiens	106-110
15351317-6	2004	Moreover, all three MAPKs were activated by PG, and PG-induced activation of MAPKs was abrogated by the treatment of PD98059, curcumin, and SB203580, specific inhibitors of MEK-1/2, stress-activated protein kinases/jun N-terminal kinase (SAPK/JNK), and p38 MAP kianse, respectively.	Curcumin	126-134	mitogen-activated protein kinase kinase 1	Mus musculus	173-180
15351317-6	2004	Moreover, all three MAPKs were activated by PG, and PG-induced activation of MAPKs was abrogated by the treatment of PD98059, curcumin, and SB203580, specific inhibitors of MEK-1/2, stress-activated protein kinases/jun N-terminal kinase (SAPK/JNK), and p38 MAP kianse, respectively.	Curcumin	126-134	mitogen-activated protein kinase 14	Mus musculus	253-256
15810596-4	2004	Above 10 mg/L concentrations curcumin induced apoptosis [Apoptosis ratio &gt; or = (14.6 +/- 1.8)%, P &lt; 0.05] and down-regulated of the expression of NF-kappaB [Expression ratio &lt; or = (35.8 +/- 4.2)%, P &lt; 0.05], Cyclin D1 [Expression ratio &lt; or = (29.7 +/- 3.2)%, P &lt; 0.05].	Curcumin	29-37	cyclin D1	Homo sapiens	222-231
15501456-2	2004	We showed that Curcumin is a potent inhibitor of Cyclosporin A resistant T cell CD28 co-stimulation pathway.	Curcumin	15-23	CD28 molecule	Homo sapiens	80-84
24445042-9	2014	In summary, these data demonstrated that low-toxic levels of curcumin could efficiently inhibit migration and invasion of lung cancer cells through inhibition of Rac1/PAK1 signaling pathway and MMP-2 and MMP-9 expression, which provided a novel insight into the molecular mechanism of curcumin against lung cancer.	Curcumin	61-69	p21 (RAC1) activated kinase 1	Homo sapiens	167-171
15179184-4	2004	Curcumin induced melanoma cell apoptosis and cell cycle arrest, which is associated with the downregulation of NFkappaB activation, iNOS and DNA-dependent protein kinase catalytic subunit expression, and upregulation of p53, p21(Cip1), p27(Kip1) and checkpoint kinase 2.	Curcumin	0-8	checkpoint kinase 2	Homo sapiens	250-269
24445042-9	2014	In summary, these data demonstrated that low-toxic levels of curcumin could efficiently inhibit migration and invasion of lung cancer cells through inhibition of Rac1/PAK1 signaling pathway and MMP-2 and MMP-9 expression, which provided a novel insight into the molecular mechanism of curcumin against lung cancer.	Curcumin	61-69	matrix metallopeptidase 2	Homo sapiens	194-199
24465712-11	2014	Curcumin significantly reduced the physical interaction of CTTN and pTyr(421)-CTTN with p120 catenin (CTNND1).	Curcumin	0-8	catenin delta 1	Homo sapiens	88-100
15037818-7	2004	These data suggest that curcumin suppresses LPS-induced COX-2 gene expression by inhibiting NF-kappaB and AP-1 DNA bindings in BV2 microglial cells.	Curcumin	24-32	prostaglandin-endoperoxide synthase 2	Mus musculus	56-61
15037818-7	2004	These data suggest that curcumin suppresses LPS-induced COX-2 gene expression by inhibiting NF-kappaB and AP-1 DNA bindings in BV2 microglial cells.	Curcumin	24-32	jun proto-oncogene	Mus musculus	106-110
15750784-9	2004	Curcumin blocks OPN-induced MT1-MMP expression and pro-MMP-2 activation.	Curcumin	0-8	matrix metallopeptidase 14	Homo sapiens	28-35
15750784-9	2004	Curcumin blocks OPN-induced MT1-MMP expression and pro-MMP-2 activation.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	55-60
15750784-12	2004	Curcumin inhibits MT1-MMP gene expression by blocking signals leading to IKK activation.	Curcumin	0-8	matrix metallopeptidase 14	Homo sapiens	18-25
14722241-5	2004	Below sublethal concentrations of curcumin (10 microM), several invasion-related genes were suppressed, including matrix metalloproteinase 14 (MMP14; 0.65-fold), neuronal cell adhesion molecule (0.54-fold), and integrins alpha6 (0.67-fold) and beta4 (0.63-fold).	Curcumin	34-42	matrix metallopeptidase 14	Homo sapiens	114-141
14722241-5	2004	Below sublethal concentrations of curcumin (10 microM), several invasion-related genes were suppressed, including matrix metalloproteinase 14 (MMP14; 0.65-fold), neuronal cell adhesion molecule (0.54-fold), and integrins alpha6 (0.67-fold) and beta4 (0.63-fold).	Curcumin	34-42	matrix metallopeptidase 14	Homo sapiens	143-148
14722241-8	2004	Curcumin (1 to 10 microM) reduced the MMP14 expression in both mRNA and protein levels and also inhibited the activity of MMP2, the down-stream gelatinase of MMP14, by gelatin zymographic analysis.	Curcumin	0-8	matrix metallopeptidase 14	Homo sapiens	38-43
14722241-8	2004	Curcumin (1 to 10 microM) reduced the MMP14 expression in both mRNA and protein levels and also inhibited the activity of MMP2, the down-stream gelatinase of MMP14, by gelatin zymographic analysis.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	122-126
14722241-8	2004	Curcumin (1 to 10 microM) reduced the MMP14 expression in both mRNA and protein levels and also inhibited the activity of MMP2, the down-stream gelatinase of MMP14, by gelatin zymographic analysis.	Curcumin	0-8	matrix metallopeptidase 14	Homo sapiens	158-163
14637190-5	2003	Remarkably, curcumin not only exerted its negative effect on FAK via the disappearance of Src-mediated FAK phosphorylation, but also directly inhibited its enzymatic activity.	Curcumin	12-20	protein tyrosine kinase 2	Homo sapiens	61-64
14637190-5	2003	Remarkably, curcumin not only exerted its negative effect on FAK via the disappearance of Src-mediated FAK phosphorylation, but also directly inhibited its enzymatic activity.	Curcumin	12-20	protein tyrosine kinase 2	Homo sapiens	103-106
14637190-7	2003	To our knowledge, this is the first report indicating that curcumin can retard cellular growth and migration via downregulation of Src and FAK kinase activity.	Curcumin	59-67	protein tyrosine kinase 2	Homo sapiens	139-142
14646185-5	2003	Curcumin, carnosol, and capsaicin also inhibited the activation of AhR in this assay, although to a lesser degree.	Curcumin	0-8	aryl hydrocarbon receptor	Homo sapiens	67-70
14634121-3	2003	In both rat primary microglia and murine BV2 microglial cells, curcumin effectively suppressed the ganglioside-, LPS-, or IFN-gamma-stimulated induction of cyclooxygenase-2 and inducible NO synthase, important enzymes that mediate inflammatory processes.	Curcumin	63-71	prostaglandin-endoperoxide synthase 2	Mus musculus	156-172
14634121-5	2003	Curcumin markedly inhibited the phosphorylation of STAT1 and 3 as well as JAK1 and 2 in microglia activated with gangliosides, LPS, or IFN-gamma.	Curcumin	0-8	signal transducer and activator of transcription 1	Rattus norvegicus	51-62
14634121-5	2003	Curcumin markedly inhibited the phosphorylation of STAT1 and 3 as well as JAK1 and 2 in microglia activated with gangliosides, LPS, or IFN-gamma.	Curcumin	0-8	Janus kinase 1	Rattus norvegicus	74-84
14634121-8	2003	Treatment of microglial cells with curcumin led to an increase in phosphorylation and association with JAK1/2 of SHP-2, which inhibit the initiation of JAK-STAT inflammatory signaling in activated microglia.	Curcumin	35-43	Janus kinase 1	Rattus norvegicus	103-109
14726605-5	2003	However, experiments with known inhibitors of activation of these transcription factors: pyrrolidine dithiocarbamate (PDTC), parthenolide and curcumin, indicate that NFkappaB and AP-1 cannot be solely responsible for the cytokine induced expression of stromelysin-1 gene in mouse astrocytes.	Curcumin	142-150	jun proto-oncogene	Mus musculus	179-183
14505349-3	2003	In this study we demonstrate that curcumin (Cur), the yellow pigment of Curcuma longa with known anti-oxidant and anti-inflammatory properties, can prevent UV irradiation-induced apoptotic changes, including c-Jun N-terminal kinase (JNK) activation, loss of mitochondrial membrane potential (MMP), mitochondrial release of cytochrome C, caspase-3 activation, and cleavage/activation of PAK2 in A431 cells.	Curcumin	34-42	p21 (RAC1) activated kinase 2	Homo sapiens	386-390
12954328-5	2003	However, curcumin did not inhibit the invasion of APN-negative tumor cells, suggesting that the antiinvasive activity of curcumin against tumor cells is attributable to the inhibition of APN.	Curcumin	121-129	alanyl aminopeptidase, membrane	Homo sapiens	187-190
12954328-6	2003	Taken together, our study revealed that curcumin is a novel irreversible inhibitor of APN that binds to curcumin resulting in inhibition of angiogenesis.	Curcumin	40-48	alanyl aminopeptidase, membrane	Homo sapiens	86-89
12954328-6	2003	Taken together, our study revealed that curcumin is a novel irreversible inhibitor of APN that binds to curcumin resulting in inhibition of angiogenesis.	Curcumin	104-112	alanyl aminopeptidase, membrane	Homo sapiens	86-89
12807725-0	2003	Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.	Curcumin	0-8	cyclin D1	Homo sapiens	212-221
12807725-0	2003	Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.	Curcumin	10-27	cyclin D1	Homo sapiens	212-221
12807725-9	2003	Exposure of cells to CS induced persistent activation of NF-kappaB, and pre-treatment with curcumin abolished the CS-induced DNA-binding of NF-kappaB, IkappaBalpha kinase activation, IkBalpha phosphorylation and degradation, p65 nuclear translocation and CS-induced NF-kappaB-dependent reporter gene expression.	Curcumin	91-99	RELA proto-oncogene, NF-kB subunit	Homo sapiens	225-228
12473670-5	2003	We also investigated the mechanism of action of curcumin (diferulolylmethane) on OPN-induced NF kappa B-mediated activation of pro-MMP-2 in B16F10 cells.	Curcumin	48-56	secreted phosphoprotein 1	Mus musculus	81-84
12473670-8	2003	However, curcumin a known anti-inflammatory and anticarcinogenic agent suppressed OPN-induced I kappa B alpha phosphorylation and degradation by inhibiting the IKK activity.	Curcumin	9-17	secreted phosphoprotein 1	Mus musculus	82-85
12473670-9	2003	Moreover, our data revealed that curcumin inhibited the OPN-induced translocation of p65, NF kappa B-DNA binding, and NF kappa B transcriptional activity.	Curcumin	33-41	secreted phosphoprotein 1	Mus musculus	56-59
12473670-10	2003	The OPN-induced pro-MMP-2 activation and MT1-MMP expression were also drastically reduced by curcumin.	Curcumin	93-101	secreted phosphoprotein 1	Mus musculus	4-7
12473670-11	2003	Curcumin also inhibited OPN-induced cell proliferation, cell migration, extracellular matrix invasion, and synergistically induced apoptotic morphology with OPN in these cells.	Curcumin	0-8	secreted phosphoprotein 1	Mus musculus	24-27
12473670-11	2003	Curcumin also inhibited OPN-induced cell proliferation, cell migration, extracellular matrix invasion, and synergistically induced apoptotic morphology with OPN in these cells.	Curcumin	0-8	secreted phosphoprotein 1	Mus musculus	157-160
12473670-12	2003	Most importantly, curcumin suppressed the OPN-induced tumor growth in nude mice, and the levels of pro-MMP-2 expression and activation in OPN-induced tumor were inhibited by curcumin.	Curcumin	18-26	secreted phosphoprotein 1	Mus musculus	42-45
12744763-12	2003	Curcumin significantly inhibited MAPK activity both 30 min after SLH (p38: 297 vs. 3260, p44/42: 370 vs. 2628, SAPK: 748 vs. 1764, all p &lt; 0.01 vs. SLH 30 min) and 4 h post CLP (p38: 146 vs. 720, p44/42: 616 vs. 2759, all p &lt; 0.01 vs. SLH + CLP4 h).	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	33-37
12744763-12	2003	Curcumin significantly inhibited MAPK activity both 30 min after SLH (p38: 297 vs. 3260, p44/42: 370 vs. 2628, SAPK: 748 vs. 1764, all p &lt; 0.01 vs. SLH 30 min) and 4 h post CLP (p38: 146 vs. 720, p44/42: 616 vs. 2759, all p &lt; 0.01 vs. SLH + CLP4 h).	Curcumin	0-8	mitogen activated protein kinase 14	Rattus norvegicus	70-73
12744763-12	2003	Curcumin significantly inhibited MAPK activity both 30 min after SLH (p38: 297 vs. 3260, p44/42: 370 vs. 2628, SAPK: 748 vs. 1764, all p &lt; 0.01 vs. SLH 30 min) and 4 h post CLP (p38: 146 vs. 720, p44/42: 616 vs. 2759, all p &lt; 0.01 vs. SLH + CLP4 h).	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	89-92
12744763-12	2003	Curcumin significantly inhibited MAPK activity both 30 min after SLH (p38: 297 vs. 3260, p44/42: 370 vs. 2628, SAPK: 748 vs. 1764, all p &lt; 0.01 vs. SLH 30 min) and 4 h post CLP (p38: 146 vs. 720, p44/42: 616 vs. 2759, all p &lt; 0.01 vs. SLH + CLP4 h).	Curcumin	0-8	mitogen activated protein kinase 14	Rattus norvegicus	181-184
12744763-12	2003	Curcumin significantly inhibited MAPK activity both 30 min after SLH (p38: 297 vs. 3260, p44/42: 370 vs. 2628, SAPK: 748 vs. 1764, all p &lt; 0.01 vs. SLH 30 min) and 4 h post CLP (p38: 146 vs. 720, p44/42: 616 vs. 2759, all p &lt; 0.01 vs. SLH + CLP4 h).	Curcumin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	199-202
12745871-0	2003	Curcumin is a potent inhibitor of phenol sulfotransferase (SULT1A1) in human liver and extrahepatic tissues.	Curcumin	0-8	sulfotransferase family 1A member 1	Homo sapiens	59-66
12745871-3	2003	The first aim was to see whether curcumin inhibited phenol sulfotransferase (SULT1A1) and, if so, to study the variability of the IC(50) of curcumin for SULT1A1 in 50 human liver samples.	Curcumin	33-41	sulfotransferase family 1A member 1	Homo sapiens	77-84
12745871-3	2003	The first aim was to see whether curcumin inhibited phenol sulfotransferase (SULT1A1) and, if so, to study the variability of the IC(50) of curcumin for SULT1A1 in 50 human liver samples.	Curcumin	140-148	sulfotransferase family 1A member 1	Homo sapiens	153-160
12745871-5	2003	The second aim was to measure the IC(50) of curcumin against SULT1A1 in five samples of human duodenum, colon, kidney and lung.	Curcumin	44-52	sulfotransferase family 1A member 1	Homo sapiens	61-68
12745871-7	2003	Curcumin was a potent inhibitor of SULT1A1 in human liver; the mean +/- SD and median of IC(50) were 14.1 +/- 7.3 nM and 12.8 nM, respectively.	Curcumin	0-8	sulfotransferase family 1A member 1	Homo sapiens	35-42
12745871-12	2003	This inhibition was greater than the IC(50) of curcumin for SULT1A1 (p &lt; 0.0001).	Curcumin	47-55	sulfotransferase family 1A member 1	Homo sapiens	60-67
12745871-14	2003	In the extrahepatic tissues, the IC(50) of curcumin for SULT1A1 was 25.9 +/- 4.8 nM (duodenum), 25.4 +/- 6.8 nM (colon), 23.4 +/- 2.2 nM (kidney) and 25.6 +/- 5.6 nM (lung).	Curcumin	43-51	sulfotransferase family 1A member 1	Homo sapiens	56-63
12745871-15	2003	Inhibition in these tissues is greater than that of curcumin for SULT1A1 in human liver (p &lt; 0.0001).	Curcumin	52-60	sulfotransferase family 1A member 1	Homo sapiens	65-72
12745871-17	2003	In conclusion, curcumin is a potent inhibitor of SULT1A1 in human liver, duodenum, colon, kidney and lung.	Curcumin	15-23	sulfotransferase family 1A member 1	Homo sapiens	49-56
12745871-18	2003	The IC(50) of curcumin for SULT1A1 varied 4.9-fold in human liver.	Curcumin	14-22	sulfotransferase family 1A member 1	Homo sapiens	27-34
12514113-0	2003	Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression.	Curcumin	0-8	glutamate-cysteine ligase catalytic subunit	Homo sapiens	61-86
12514113-2	2003	Correlations have been established between curcumin exposure and increases in enzymes for glutathione synthesis, particularly glutamate-cysteine ligase (GCL), and metabolism as well as glutathione content, suggesting the eliciting of an adaptive response to stress.	Curcumin	43-51	glutamate-cysteine ligase catalytic subunit	Homo sapiens	126-151
12514113-2	2003	Correlations have been established between curcumin exposure and increases in enzymes for glutathione synthesis, particularly glutamate-cysteine ligase (GCL), and metabolism as well as glutathione content, suggesting the eliciting of an adaptive response to stress.	Curcumin	43-51	glutamate-cysteine ligase catalytic subunit	Homo sapiens	153-156
12514113-3	2003	In this study, using HBE1 cells, we found that the mechanism of curcumin-induced GCL elevation occurred via transcription of the two Gcl genes.	Curcumin	64-72	glutamate-cysteine ligase catalytic subunit	Homo sapiens	81-84
12514113-3	2003	In this study, using HBE1 cells, we found that the mechanism of curcumin-induced GCL elevation occurred via transcription of the two Gcl genes.	Curcumin	64-72	glutamate-cysteine ligase catalytic subunit	Homo sapiens	133-136
12514113-6	2003	Curcumin exposure increased JunD and c-Jun content in AP-1 complexes and increased JunD while decreasing MafG/MafK in EpRE complexes.	Curcumin	0-8	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-32
12514113-6	2003	Curcumin exposure increased JunD and c-Jun content in AP-1 complexes and increased JunD while decreasing MafG/MafK in EpRE complexes.	Curcumin	0-8	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	83-87
12514113-6	2003	Curcumin exposure increased JunD and c-Jun content in AP-1 complexes and increased JunD while decreasing MafG/MafK in EpRE complexes.	Curcumin	0-8	MAF bZIP transcription factor K	Homo sapiens	110-114
12514113-7	2003	Thus, the beneficial effects elicited by curcumin appear to be due to changes in the pool of transcription factors that compose EpRE and AP-1 complexes, affecting gene expression of GCL and other phase II enzymes.	Curcumin	41-49	glutamate-cysteine ligase catalytic subunit	Homo sapiens	182-185
12543061-10	2003	Intragastric administration of BDMC-A and curcumin to DMH administered rats significantly lowered the cholesterol content and raised the phospholipid content and lowered the activities of PLA and PLC towards near normal values.	Curcumin	42-50	phospholipase A and acyltransferase 1	Rattus norvegicus	188-191
12578124-3	2003	Curcumin, an anti-inflammatory remedy used in Indian medicine, is known to suppress NF-kappaB and AP-1 activation and also to reduce ischemia-reperfusion injuries in animal models.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	98-102
12578124-4	2003	Therefore, the aim of this study was to determine whether administration of curcumin before hemorrhagic shock has any salutary effects on cytokines and the redox-sensitive transcription factors NF-kappaB and AP-1.	Curcumin	76-84	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	208-212
12578124-6	2003	The effect of curcumin on the activation of NF-kappaB and AP-1 was determined by electrophoretic mobility shift assays.	Curcumin	14-22	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-62
12578124-10	2003	NF-kappaB and AP-1 were differentially activated at 2 and 24 h posthemorrhage and were inhibited by curcumin pretreatment.	Curcumin	100-108	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-18
12446602-9	2002	When introduced into 3T3-L1 adipocytes, curcumin markedly inhibited insulin-induced GLUT4 translocation and glucose transport.	Curcumin	40-48	solute carrier family 2 member 4	Homo sapiens	84-89
12130649-12	2002	On the other hand, TGF-beta-induced production of type I collagen was antagonized by curcumin but not by PD98059.	Curcumin	85-93	transforming growth factor, beta 1	Mus musculus	19-27
12050094-12	2002	Curcumin may be useful in the chemoprevention of human intestinal malignancies related to Apc mutations.	Curcumin	0-8	APC regulator of WNT signaling pathway	Homo sapiens	90-93
12297018-3	2002	In this study, we have found that curcumin inhibits the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced nuclear factor kB (NF-kappaB) activation by preventing the degradation of the inhibitory protein IkBalpa; and the subsequent translocation of the p65 subunit in cultured human promyelocytic leukemia (HL-60) cells.	Curcumin	34-42	RELA proto-oncogene, NF-kB subunit	Homo sapiens	253-256
11756235-0	2002	Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.	Curcumin	0-8	caspase 8	Homo sapiens	69-78
11756235-0	2002	Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.	Curcumin	10-27	caspase 8	Homo sapiens	69-78
11756235-6	2002	Curcumin activated caspase-8 and caspase-3 in HL-60 neo cells but not in Bcl-2 and Bcl-xl-transfected cells.	Curcumin	0-8	caspase 8	Homo sapiens	19-28
11756235-10	2002	Because DN-FLICE blocked curcumin-induced apoptosis, caspase-8 must play a critical role.	Curcumin	25-33	caspase 8	Homo sapiens	11-16
11756235-11	2002	Overall, our results indicate that curcumin induces apoptosis through mitochondrial pathway involving caspase-8, BID cleavage, cytochrome c release, and caspase-3 activation.	Curcumin	35-43	caspase 8	Homo sapiens	102-111
11221833-2	2001	Pharmacological activities of curcumin in cells in situ germane to chemoprevention, such as inhibition of expression of cyclooxygenase-2 (COX-2), require drug concentrations in the 10(-5) - 10(-4) M range.	Curcumin	30-38	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	120-136
11221833-2	2001	Pharmacological activities of curcumin in cells in situ germane to chemoprevention, such as inhibition of expression of cyclooxygenase-2 (COX-2), require drug concentrations in the 10(-5) - 10(-4) M range.	Curcumin	30-38	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	138-143
11221833-13	2001	To test the hypothesis that curcumin metabolites resemble their progenitor in that they can inhibit COX-2 expression, curcumin and four of its metabolites at a concentration of 20 microM were compared in terms of their ability to inhibit phorbol ester-induced prostaglandin E2 (PGE2) production in human colonic epithelial cells.	Curcumin	28-36	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	100-105
11221833-15	2001	The results suggest that (a) the major products of curcumin biotransformation by hepatocytes occur only at low abundance in rat plasma after curcumin administration; and (b) metabolism of curcumin by reduction or conjugation generates species with reduced ability to inhibit COX-2 expression.	Curcumin	51-59	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	275-280
11231886-4	2001	Topical application of curcumin was reported to inhibit TPA-induced c-fos, c-jun and c-myc gene expression in mouse skin.	Curcumin	23-31	jun proto-oncogene	Mus musculus	75-80
11231886-8	2001	CONCLUSIONS: Whereas earlier work demonstrated that topical application of curcumin to mouse skin inhibited TPA-induced expression of c-fos, c-jun and c-myc oncogenes, our results are the first to show that orally consumed curcumin significantly inhibited DMBA- and TPA-induced ras and fos gene expression in mouse skin.	Curcumin	75-83	jun proto-oncogene	Mus musculus	141-146
11029517-4	2000	In the current study, we investigated the fate of curcumin when used as a soybean lipoxygenase L3 substrate.	Curcumin	50-58	seed linoleate 9S-lipoxygenase-3	Glycine max	82-97
11234915-4	2000	glutathione peroxidase (GPx) and D-glucose-6-phosphate dehydrogenase (G6PD), were also diminished by curcumin.	Curcumin	101-109	glucose-6-phosphate dehydrogenase X-linked	Mus musculus	33-68
11234915-4	2000	glutathione peroxidase (GPx) and D-glucose-6-phosphate dehydrogenase (G6PD), were also diminished by curcumin.	Curcumin	101-109	glucose-6-phosphate dehydrogenase X-linked	Mus musculus	70-74
11234915-5	2000	These results indicate that curcumin significantly suppresses TCE-induced oxidative stress by scavenging various free radicals, and its antioxidative activity seems to be derived from its suppressive effects on the increase in peroxisome content and decrease in GPx and G6PD activities.	Curcumin	28-36	glucose-6-phosphate dehydrogenase X-linked	Mus musculus	270-274
10657978-11	2000	While hepatic tissues obtained from the DEN-treated mice showed a remarkable increase in the levels of p21(ras), PCNA and CDC2 proteins, eating a curcumin-containing diet reversed the levels to normal values.	Curcumin	146-154	cyclin-dependent kinase 1	Mus musculus	122-126
10965519-2	2000	In this report, we analyzed the biological behavior of two naturally occurring inhibitors of protein tyrosine kinases, genistein and curcumin, that could abrogate the enhancement of u-PA levels induced by TGF-beta 1 in transformed keratinocytes.	Curcumin	133-141	transforming growth factor, beta 1	Mus musculus	205-215
10965519-3	2000	Our results showed that genistein and curcumin blocked this response in a dose-dependent manner and also inhibited the TGF-beta 1-induced synthesis of fibronectin, an early responsive gene to the growth factor.	Curcumin	38-46	transforming growth factor, beta 1	Mus musculus	119-129
10570055-9	1999	4-HPR-induced apoptosis in LNCaP cells was suppressed by curcumin, which inhibits JNK activation.	Curcumin	57-65	haptoglobin-related protein	Homo sapiens	2-5
10477620-6	1999	Cytokine-induced NF-kappa B DNA binding activity, RelA nuclear translocation, I kappa B alpha degradation, I kappa B serine 32 phosphorylation, and I kappa B kinase (IKK) activity were blocked by curcumin treatment.	Curcumin	196-204	RELA proto-oncogene, NF-kB subunit	Homo sapiens	50-54
9674701-10	1998	Taken together, the inhibition of the MEKK1-JNK pathway reveals a possible mechanism of suppression of AP-1 and NF-kappaB signaling by curcumin, and may explain the potent anti-inflammatory and anti-carcinogenic effects of this chemical.	Curcumin	135-143	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	38-43
11322764-10	2001	The protective effect of curcumin against Stx1 and Stx2-induced injury to HK-2 was not related to its antioxidant properties.	Curcumin	25-33	hexokinase 2	Homo sapiens	74-78
11322764-11	2001	Instead, curcumin enhanced expression of heat shock protein 70 (HSP70) in HK-2 cells under control conditions and after exposure to Stx1 or Stx2.	Curcumin	9-17	hexokinase 2	Homo sapiens	74-78
11322764-13	2001	Thus, curcumin inhibits Stx-induced apoptosis and necrosis in HK-2 cells in vitro.	Curcumin	6-14	hexokinase 2	Homo sapiens	62-66
11370761-6	2001	In addition, curcumin inhibits the activation of NFkappaB and the expression of c-jun, c-fos, c-myc and iNOS.	Curcumin	13-21	jun proto-oncogene	Mus musculus	80-85
24465712-11	2014	Curcumin significantly reduced the physical interaction of CTTN and pTyr(421)-CTTN with p120 catenin (CTNND1).	Curcumin	0-8	catenin delta 1	Homo sapiens	102-108
11077049-2	2000	In this study, we investigated the inhibitory effects of curcumin and its metabolites, tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin, on the induction of NO synthase (NOS) in RAW 264.7 cells activated with lipopolysaccharide (LPS).	Curcumin	57-65	nitric oxide synthase 1, neuronal	Mus musculus	169-180
11237176-5	2000	Subsequently, curcumin inhibits the activation of NFkappaB and the expressions of c-jun, c-fos, c-myc and iNOS.	Curcumin	14-22	jun proto-oncogene	Mus musculus	82-87
24596618-3	2014	Curcumin inhibited cyclooxygenase-2 (COX-2) dependent prostaglandin D2 (PGD2) and 5-lipoxygenase (5-LO) dependent leukotriene C4 (LTC4) generation dose-dependently in BMMCs.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	19-35
11688958-4	2000	Oral administration of curcumin, which downregulates AP-1 transcription, significantly inhibited the mediastinal lymph node metastasis of orthotopically implanted LLC cells in a dose-dependent manner, but did not affect the tumor growth at the implantation site.	Curcumin	23-31	jun proto-oncogene	Mus musculus	53-57
24596618-3	2014	Curcumin inhibited cyclooxygenase-2 (COX-2) dependent prostaglandin D2 (PGD2) and 5-lipoxygenase (5-LO) dependent leukotriene C4 (LTC4) generation dose-dependently in BMMCs.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	37-42
11688958-6	2000	The downregulation of transcriptional AP-1 activity by curcumin as seen in the dual luciferase assay caused inhibition of LLC cell invasion through the repression of expression of the mRNAs for urokinase-type plasminogen activator (u-PA) and its receptor (u-PAR).	Curcumin	55-63	jun proto-oncogene	Mus musculus	38-42
24596618-5	2014	Curcumin inhibited intracellular Ca(2+) influx via phospholipase Cgamma1 (PLCgamma1) activation and the phosphorylation of mitogen-activated protein kinases (MAPKs) and the nuclear factor-kappaB (NF-kappaB) pathway.	Curcumin	0-8	T cell receptor gamma, constant 1	Mus musculus	65-72
10666014-7	2000	Interestingly, curcumin prevented the general toxicity and mortality induced by PQ and blocked the rise in BALF protein, ACE, AKP, NAG TBARS and neutrophils.	Curcumin	15-23	O-GlcNAcase	Rattus norvegicus	131-134
24484590-0	2014	Potent anti-angiogenic activity of B19--a mono-carbonyl analogue of curcumin.	Curcumin	68-76	eva-1 homolog C	Homo sapiens	35-38
10555784-8	1999	Curcumin, which inhibits AP-1 activity, blocked the NGF-mediated rescue.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	25-29
10555784-8	1999	Curcumin, which inhibits AP-1 activity, blocked the NGF-mediated rescue.	Curcumin	0-8	nerve growth factor	Rattus norvegicus	52-55
24484590-1	2014	AIM: The compound B19 (C21H22O5) is a newly synthesized, mono-carbonyl analog of curcumin that has exhibited potential antitumor effects.	Curcumin	81-89	eva-1 homolog C	Homo sapiens	18-21
24138392-9	2014	In addition, miR-29b was involved in the hypomethylation of PTEN by curcumin.	Curcumin	68-76	microRNA 29b-1	Homo sapiens	13-20
10514034-10	1999	Taken together, these results suggest that GSTs play a major role in detoxification of lipid peroxidation products in K562 cells, and that these enzymes are modulated by curcumin.	Curcumin	170-178	glutathione S-transferase, alpha 4	Mus musculus	43-47
10444406-9	1999	Consistent with the promoter and gel-shift studies, curcumin, an inhibitor of AP-1 activation, suppressed the HB-EGF mRNA induction after stretch.	Curcumin	52-60	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	78-82
9918209-8	1999	I kappa B alpha, a previously identified NF-kappa B-inducible gene, was overexpressed in human pancreatic tumor tissues and cell lines, and RelA activation could be inhibited by curcumin and dominant-negative mutants of I kappa B alpha, raf, and MEKK1.	Curcumin	178-186	RELA proto-oncogene, NF-kB subunit	Homo sapiens	140-144
9764849-6	1998	Supportive of these findings, p53 downstream targets, including p21(CIP1/WAF1) and Gadd45, could be induced to localize on the nucleus by curcumin with similar p53 kinetics.	Curcumin	138-146	growth arrest and DNA damage inducible alpha	Homo sapiens	83-89
9733605-12	1998	PMA-CD28 group cells treated with 10 microgram/ml curcumin showed a significantly increased apoptosis as compared to control (0.4% DMSO).	Curcumin	50-58	CD28 molecule	Homo sapiens	4-8
24138392-10	2014	MiR-29b not only was increased by curcumin in activated HSCs, but also was confirmed to target DNMT3b by luciferase activity assays.	Curcumin	34-42	microRNA 29b-1	Homo sapiens	0-7
9764755-5	1998	Induction of Hsp27, alphaB crystallin and Hsp70 in the liver and adrenal glands of heat-stressed (42 degrees C for 20 min) rats was also enhanced by prior injection of curcumin (20 mg/kg body weight).	Curcumin	168-176	heat shock protein family B (small) member 1	Rattus norvegicus	13-18
24138392-11	2014	Curcumin-mediated PTEN up-regulation, DNMT3b down-regulation and PTEN hypomethylation were all attenuated by miR-29b inhibitor.	Curcumin	0-8	microRNA 29b-1	Homo sapiens	109-116
9764755-5	1998	Induction of Hsp27, alphaB crystallin and Hsp70 in the liver and adrenal glands of heat-stressed (42 degrees C for 20 min) rats was also enhanced by prior injection of curcumin (20 mg/kg body weight).	Curcumin	168-176	crystallin, alpha B	Rattus norvegicus	20-37
24138392-12	2014	Collectively, it is demonstrated that curcumin can up-regulate miR-29b expression, resulting in DNMT3b down-regulation in HSCs and epigenetically-regulated PTEN involved in the suppression of activated HSCs.	Curcumin	38-46	microRNA 29b-1	Homo sapiens	63-70
24868317-9	2014	Curcumin significantly reduced the number of apoptotic cells and inhibited the upregulation of cyt-c, caspase-9, and caspase-3 at 7 days p.i.	Curcumin	0-8	caspase 9	Mus musculus	102-111
9698073-0	1998	Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells.	Curcumin	10-18	aryl hydrocarbon receptor	Homo sapiens	26-51
9698073-1	1998	We examined the interaction of curcumin, a dietary constituent and chemopreventive compound, with the carcinogen activation pathway mediated by the aryl hydrocarbon receptor (AhR) in MCF-7 mammary epithelial carcinoma cells.	Curcumin	31-39	aryl hydrocarbon receptor	Homo sapiens	148-173
9698073-1	1998	We examined the interaction of curcumin, a dietary constituent and chemopreventive compound, with the carcinogen activation pathway mediated by the aryl hydrocarbon receptor (AhR) in MCF-7 mammary epithelial carcinoma cells.	Curcumin	31-39	aryl hydrocarbon receptor	Homo sapiens	175-178
9698073-3	1998	Curcumin activated the DNA-binding capacity of the AhR for the xenobiotic responsive element of CYP1A1 as measured by the electrophoretic-mobility shift assay (EMSA).	Curcumin	0-8	aryl hydrocarbon receptor	Homo sapiens	51-54
9698073-4	1998	Curcumin was able to compete with the prototypical AhR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin for binding to the AhR in isolated MCF-7 cytosol, indicating that it interacts directly with the receptor.	Curcumin	0-8	aryl hydrocarbon receptor	Homo sapiens	51-54
9698073-4	1998	Curcumin was able to compete with the prototypical AhR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin for binding to the AhR in isolated MCF-7 cytosol, indicating that it interacts directly with the receptor.	Curcumin	0-8	aryl hydrocarbon receptor	Homo sapiens	117-120
10780880-5	1998	MATERIALS AND METHODS: Curcumin was tested for its ability to inhibit the proliferation of primary endothelial cells in the presence and absence of basic fibroblast growth factor (bFGF), as well as its ability to inhibit proliferation of an immortalized endothelial cell line.	Curcumin	23-31	fibroblast growth factor 2	Mus musculus	148-178
10780880-5	1998	MATERIALS AND METHODS: Curcumin was tested for its ability to inhibit the proliferation of primary endothelial cells in the presence and absence of basic fibroblast growth factor (bFGF), as well as its ability to inhibit proliferation of an immortalized endothelial cell line.	Curcumin	23-31	fibroblast growth factor 2	Mus musculus	180-184
10780880-6	1998	Curcumin and its derivatives were subsequently tested for their ability to inhibit bFGF-induced corneal neovascularization in the mouse cornea.	Curcumin	0-8	fibroblast growth factor 2	Mus musculus	83-87
10780880-9	1998	Curcumin and its derivatives demonstrated significant inhibition of bFGF-mediated corneal neovascularization in the mouse.	Curcumin	0-8	fibroblast growth factor 2	Mus musculus	68-72
9437186-7	1997	The present data show that curcumin prevented the activation of c-Rel/p65, which is essential for TF gene activation in endothelial cells, by impairing the proteolytic degradation inhibitor protein, I kappa B alpha.	Curcumin	27-35	RELA proto-oncogene, NF-kB subunit	Homo sapiens	70-73
9698073-5	1998	Although curcumin could activate the AhR on its own, it partially inhibited the activation of AhR, as measured by EMSA, and partially decreased the accumulation of CYP1A1 mRNA caused by the mammary carcinogen dimethylbenzanthracene (DMBA).	Curcumin	9-17	aryl hydrocarbon receptor	Homo sapiens	37-40
9698073-5	1998	Although curcumin could activate the AhR on its own, it partially inhibited the activation of AhR, as measured by EMSA, and partially decreased the accumulation of CYP1A1 mRNA caused by the mammary carcinogen dimethylbenzanthracene (DMBA).	Curcumin	9-17	aryl hydrocarbon receptor	Homo sapiens	94-97
9353136-0	1997	Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics.	Curcumin	0-8	interleukin 5	Homo sapiens	56-69
9353136-0	1997	Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics.	Curcumin	0-8	interleukin 5	Homo sapiens	71-75
24184124-9	2014	In conclusion, these data demonstrate that by selectively activating the ERbeta, raloxifen, tamoxifen, genistein and curcumin inhibit human PC cells proliferation and migration favoring cell adesion.	Curcumin	117-125	estrogen receptor 2	Homo sapiens	73-79
9353136-6	1997	Furthermore, curcumin inhibited IL-5, GM-CSF, and IL-4 production in a concentration-dependent manner.	Curcumin	13-21	interleukin 5	Homo sapiens	32-36
9698073-8	1998	These results suggest that the chemopreventive effect of curcumin may be due, in part, to its ability to compete with aryl hydrocarbons for both the AhR and CYP1A1.	Curcumin	57-65	aryl hydrocarbon receptor	Homo sapiens	149-152
9698073-9	1998	Curcumin may thus be a natural ligand and substrate of the AhR pathway.	Curcumin	0-8	aryl hydrocarbon receptor	Homo sapiens	59-62
9720770-22	1998	The level of c-myc mRNA was significantly reduced by curcumin (10(-5)-10(-4) M) treatment.	Curcumin	53-61	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	13-18
9720770-25	1998	The effects of curcumin on the levels of c-myc and bcl-2 mRNA were then confirmed by Northern blotting.	Curcumin	15-23	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	41-46
23906792-4	2013	CTGF-induced collagen I expression was inhibited by the dominant negative mutant (DN) of Rac1 (RacN17), MLK3DN, MLK3 inhibitor (K252a), JNK1DN, JNK2DN, a JNK inhibitor (SP600125), and an AP-1 inhibitor (curcumin).	Curcumin	203-211	cellular communication network factor 2	Homo sapiens	0-4
9720770-29	1998	Our results suggest that the antiproliferative effect of curcumin may partly be mediated through inhibition of protein tyrosine kinase activity and c-myc mRNA expression.	Curcumin	57-65	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	148-153
9049662-3	1997	The highest dose of curcumin significantly enhanced IgG levels.	Curcumin	20-28	immunoglobulin heavy chain (V7183 family)	Mus musculus	52-55
9589348-9	1997	Curcumin (10 microM) suppressed the expression of c-jun in TPA-treated cells.	Curcumin	0-8	jun proto-oncogene	Mus musculus	50-55
8837865-2	1996	Curcumin (0.4 g/kg body wt/day) induced a significant increase in the hepatic levels of glutathione-S-transferase (GST), acid-soluble sulfhydryl (SH), cytochrome b5, and cytochrome P-450 in lactating dams and F1 pups at 14 or 21 days.	Curcumin	0-8	cytochrome b5 type A (microsomal)	Mus musculus	151-164
8837865-5	1996	Curcumin-induced levels of GST and SH were depressed whereas cytochrome b5 and cytochrome P-450 were further elevated by curcumin+arecoline treatment.	Curcumin	121-129	cytochrome b5 type A (microsomal)	Mus musculus	61-74
7511111-4	1994	At around 0.1 mM curcumin, PhK, pp60c-src, PkC, PkA, AK, and cPK were inhibited by 98%, 40%, 15%, 10%, 1%, and 0.5%, respectively.	Curcumin	17-25	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	61-64
33806197-2	2021	A recently designed, synthesized and tested hybrid compound between the AChE inhibitor galantamine (GAL) and the antioxidant polyphenol curcumin (CU) showed high AChE inhibition in vitro.	Curcumin	136-144	acetylcholinesterase	Mus musculus	72-76
33806197-2	2021	A recently designed, synthesized and tested hybrid compound between the AChE inhibitor galantamine (GAL) and the antioxidant polyphenol curcumin (CU) showed high AChE inhibition in vitro.	Curcumin	136-144	acetylcholinesterase	Mus musculus	162-166
33806197-2	2021	A recently designed, synthesized and tested hybrid compound between the AChE inhibitor galantamine (GAL) and the antioxidant polyphenol curcumin (CU) showed high AChE inhibition in vitro.	Curcumin	146-148	acetylcholinesterase	Mus musculus	72-76
33806197-2	2021	A recently designed, synthesized and tested hybrid compound between the AChE inhibitor galantamine (GAL) and the antioxidant polyphenol curcumin (CU) showed high AChE inhibition in vitro.	Curcumin	146-148	acetylcholinesterase	Mus musculus	162-166
33806197-7	2021	In the ex vivo tests, the GAL-CU hybrid performed better than GAL and CU themselves; in a dose of 5 mg/kg, it demonstrates 25% reduction in AChE activity, as well as a 28% and 73% increase in the levels of MDA and GSH, respectively.	Curcumin	30-32	acetylcholinesterase	Mus musculus	140-144
33803989-2	2021	In this study, a novel nanoparticular system of a model drug curcumin (CUR) based on FNP technique was developed by using cheap and commercially available amphiphilic poly(vinyl pyrrolidone) (PVP) as stabilizer and natural polymer chitosan (CS) as trapping agent.	Curcumin	61-69	citrate synthase	Homo sapiens	241-243
33773562-0	2021	Curcumin Rescues Doxorubicin Responsiveness via Regulating Aurora a Signaling Network in Breast Cancer Cells.	Curcumin	0-8	aurora kinase A	Homo sapiens	59-67
33773562-5	2021	Effect of curcumin, a natural phytochemical in restoring doxorubicin sensitivity by targeting Aurora A was assessed furthermore.	Curcumin	10-18	aurora kinase A	Homo sapiens	94-102
33773562-14	2021	To explore the possible outcome of impact of curcumin on Aurora A, cell-cycle distribution and apoptosis were performed subsequently.	Curcumin	45-53	aurora kinase A	Homo sapiens	57-65
33773562-18	2021	Curcumin by regulating Aurora A and its target molecules sensitized resistant subline towards doxorubicin mediated G2/M-arrest and apoptosis.	Curcumin	0-8	aurora kinase A	Homo sapiens	23-31
33773562-19	2021	CONCLUSION: Molecular targeting of Aurora A by curcumin restores chemosensitivity by increasing the efficacy of doxorubicin in breast cancer.<br />.	Curcumin	47-55	aurora kinase A	Homo sapiens	35-43
22771723-4	2012	Curcumin inhibited cell viability and the MMP-2/9 activities of human bladder cancer cells.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	42-47
34894517-7	2022	Furthermore, The genes encoding Col1a1, Fasn, Pck1, Bmp10, IL33 and Figf were pivotal and possible key genes for the therapeutic mechanisms of curcumin.Curcumin can reduce the degree of left atrial fibrosis of AF and the secretion of inflammatory factors.	Curcumin	143-151	fatty acid synthase	Rattus norvegicus	40-44
34894517-7	2022	Furthermore, The genes encoding Col1a1, Fasn, Pck1, Bmp10, IL33 and Figf were pivotal and possible key genes for the therapeutic mechanisms of curcumin.Curcumin can reduce the degree of left atrial fibrosis of AF and the secretion of inflammatory factors.	Curcumin	143-151	bone morphogenetic protein 10	Rattus norvegicus	52-57
34894517-7	2022	Furthermore, The genes encoding Col1a1, Fasn, Pck1, Bmp10, IL33 and Figf were pivotal and possible key genes for the therapeutic mechanisms of curcumin.Curcumin can reduce the degree of left atrial fibrosis of AF and the secretion of inflammatory factors.	Curcumin	143-151	interleukin 33	Rattus norvegicus	59-63
34894517-7	2022	Furthermore, The genes encoding Col1a1, Fasn, Pck1, Bmp10, IL33 and Figf were pivotal and possible key genes for the therapeutic mechanisms of curcumin.Curcumin can reduce the degree of left atrial fibrosis of AF and the secretion of inflammatory factors.	Curcumin	152-160	fatty acid synthase	Rattus norvegicus	40-44
34894517-7	2022	Furthermore, The genes encoding Col1a1, Fasn, Pck1, Bmp10, IL33 and Figf were pivotal and possible key genes for the therapeutic mechanisms of curcumin.Curcumin can reduce the degree of left atrial fibrosis of AF and the secretion of inflammatory factors.	Curcumin	152-160	bone morphogenetic protein 10	Rattus norvegicus	52-57
34894517-7	2022	Furthermore, The genes encoding Col1a1, Fasn, Pck1, Bmp10, IL33 and Figf were pivotal and possible key genes for the therapeutic mechanisms of curcumin.Curcumin can reduce the degree of left atrial fibrosis of AF and the secretion of inflammatory factors.	Curcumin	152-160	interleukin 33	Rattus norvegicus	59-63
34894517-9	2022	Besides, COL1A1, FASN, PCK1, BMP10, IL33 and FIGF were the pivotal genes associated with mechanisms of action of curcumin on AF.	Curcumin	113-121	fatty acid synthase	Rattus norvegicus	17-21
34894517-9	2022	Besides, COL1A1, FASN, PCK1, BMP10, IL33 and FIGF were the pivotal genes associated with mechanisms of action of curcumin on AF.	Curcumin	113-121	bone morphogenetic protein 10	Rattus norvegicus	29-34
34894517-9	2022	Besides, COL1A1, FASN, PCK1, BMP10, IL33 and FIGF were the pivotal genes associated with mechanisms of action of curcumin on AF.	Curcumin	113-121	interleukin 33	Rattus norvegicus	36-40
34614532-0	2022	Evaluation of Protective Effects of Curcumin and Nanocurcumin on Aluminium Phosphide-Induced Subacute Lung Injury in Rats: Modulation of Oxidative Stress through SIRT1/FOXO3 Signalling Pathway.	Curcumin	36-44	forkhead box O3	Rattus norvegicus	168-173
34614532-9	2022	RESULTS: Curcumin and nanocurcumin produced a remarkable improvement in AlP-induced lung damage through reduction of MDA, induction of antioxidant capacity (TAC, TTG) and antioxidant enzymes (CAT, GPx), modulation of histopathological changes, and up-regulation of genes expression of SIRT1, FOXO3, FOXO1 in lung tissue.	Curcumin	9-17	forkhead box O3	Rattus norvegicus	292-297
34614532-9	2022	RESULTS: Curcumin and nanocurcumin produced a remarkable improvement in AlP-induced lung damage through reduction of MDA, induction of antioxidant capacity (TAC, TTG) and antioxidant enzymes (CAT, GPx), modulation of histopathological changes, and up-regulation of genes expression of SIRT1, FOXO3, FOXO1 in lung tissue.	Curcumin	9-17	forkhead box O1	Rattus norvegicus	299-304
34939316-9	2022	Curcumin reduced the expression of the genes analysed, especially MMP-9, TGF-beta and collagen I.	Curcumin	0-8	transforming growth factor alpha	Homo sapiens	73-81
34939316-10	2022	Moreover, curcumin inhibited the HRV-induced expression of MMP-9, TGF-beta, collagen I and LTC4S (p < 0.05).	Curcumin	10-18	transforming growth factor alpha	Homo sapiens	66-74
34910275-0	2022	Correction to: Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of miR-34a.	Curcumin	38-46	microRNA 34a	Homo sapiens	145-152
33975498-0	2021	Synergistic effect of the anti-PD-1 antibody with blood stable and reduction sensitive curcumin micelles on colon cancer.	Curcumin	87-95	programmed cell death 1	Homo sapiens	31-35
34357837-12	2021	Furthermore, curcumin suppressed EMT by targeting BAMBI via the TLR4/BAMBI/TGF-beta1 signalling pathway in vitro, demonstrating its potential utility in BPH treatment.	Curcumin	13-21	transforming growth factor, beta 1	Mus musculus	75-84
34806141-0	2022	Curcumin induces apoptosis through caspase dependent pathway in human colon carcinoma cells.	Curcumin	0-8	caspase 8	Homo sapiens	35-42
34571370-0	2021	Combination of azacytidine and curcumin is a potential alternative in decitabine-resistant colorectal cancer cells with attenuated deoxycytidine kinase.	Curcumin	31-39	deoxycytidine kinase	Homo sapiens	131-151
34835741-0	2021	CD123-Targeted Nano-Curcumin Molecule Enhances Cytotoxic Efficacy in Leukemic Stem Cells.	Curcumin	20-28	interleukin 3 receptor subunit alpha	Homo sapiens	0-5
34835741-7	2021	In this study, we aimed to formulate curcumin nanoparticles and conjugate with the anti-CD123 to overcome the low water solubility and improve the targeting of LSCs.	Curcumin	37-45	interleukin 3 receptor subunit alpha	Homo sapiens	88-93
34835741-8	2021	The cytotoxicity of both curcumin-loaded PLGA/poloxamer nanoparticles (Cur-NPs) and anti-CD123-curcumin-loaded PLGA/poloxamer nanoparticles (anti-CD123-Cur-NPs) were examined in KG-1a cells.	Curcumin	95-103	interleukin 3 receptor subunit alpha	Homo sapiens	89-94
34835741-12	2021	In conclusion, the anti-CD123-Cur-NPs formulation improved curcumin"s bioavailability and specific targeting of LSCs, suggesting that it is a promising drug delivery system for improving the therapeutic efficacy against AML.	Curcumin	59-67	interleukin 3 receptor subunit alpha	Homo sapiens	24-29
34592487-12	2021	In addition, Curcumin inhibited expression of CD4+CD25+FoxP3+ Treg cells as well as PD-1 and TIM-3.	Curcumin	13-21	interleukin 2 receptor subunit alpha	Homo sapiens	50-54
34592487-12	2021	In addition, Curcumin inhibited expression of CD4+CD25+FoxP3+ Treg cells as well as PD-1 and TIM-3.	Curcumin	13-21	forkhead box P3	Homo sapiens	55-60
34592487-12	2021	In addition, Curcumin inhibited expression of CD4+CD25+FoxP3+ Treg cells as well as PD-1 and TIM-3.	Curcumin	13-21	hepatitis A virus cellular receptor 2	Mus musculus	93-98
34720999-7	2021	Treatment with curcumin (an antioxidant) significantly protected against G2385R-LRRK2-induced neurodegeneration by reducing mitochondrial ROS, caspase-3/7 activation, and PARP cleavage.	Curcumin	15-23	leucine-rich repeat kinase 2	Mus musculus	80-85
34720999-7	2021	Treatment with curcumin (an antioxidant) significantly protected against G2385R-LRRK2-induced neurodegeneration by reducing mitochondrial ROS, caspase-3/7 activation, and PARP cleavage.	Curcumin	15-23	collagen type XI alpha 2 chain	Homo sapiens	171-175
34720999-8	2021	We also found that the cellular environmental stressor, H2O2 significantly promotes both WT-LRRK2- and G2385R-LRRK2-induced neurotoxicity by increasing mitochondrial ROS, caspase-3/7 activation, and PARP cleavage, while curcumin attenuated this combined neurotoxicity.	Curcumin	220-228	leucine-rich repeat kinase 2	Mus musculus	110-115
34517007-8	2021	Curcumin analog compound C1, a specific TFEB activator, similarly attenuated PE-induced ALP insufficiency and cardiomyocyte hypertrophy.	Curcumin	0-8	transcription factor EB	Homo sapiens	40-44
34670669-0	2021	(Curcumin combined with 5-FU promotes autophagy and down-regulates the expression of Yes-associated protein (YAP) in hepatocellular carcinoma cells).	Curcumin	1-9	Yes1 associated transcriptional regulator	Homo sapiens	85-107
34670669-0	2021	(Curcumin combined with 5-FU promotes autophagy and down-regulates the expression of Yes-associated protein (YAP) in hepatocellular carcinoma cells).	Curcumin	1-9	Yes1 associated transcriptional regulator	Homo sapiens	109-112
34670669-1	2021	Objective To investigate the effect of curcumin combined with 5-FU on autophagy and Yes-associated protein (YAP) expression in hepatocellular carcinoma cells.	Curcumin	39-47	Yes1 associated transcriptional regulator	Homo sapiens	84-106
34670669-1	2021	Objective To investigate the effect of curcumin combined with 5-FU on autophagy and Yes-associated protein (YAP) expression in hepatocellular carcinoma cells.	Curcumin	39-47	Yes1 associated transcriptional regulator	Homo sapiens	108-111
34670669-6	2021	Compared with the control group, group with curcumin, group with 5-FU, and combination group could increase the expression level of LC3II protein and decrease that of YAP in HepG2 cells, HepG2 cells with stable YAP overexpression, and HepG2 cells with stable YAP knockdown.	Curcumin	44-52	Yes1 associated transcriptional regulator	Homo sapiens	167-170
34670669-6	2021	Compared with the control group, group with curcumin, group with 5-FU, and combination group could increase the expression level of LC3II protein and decrease that of YAP in HepG2 cells, HepG2 cells with stable YAP overexpression, and HepG2 cells with stable YAP knockdown.	Curcumin	44-52	Yes1 associated transcriptional regulator	Homo sapiens	211-214
34670669-6	2021	Compared with the control group, group with curcumin, group with 5-FU, and combination group could increase the expression level of LC3II protein and decrease that of YAP in HepG2 cells, HepG2 cells with stable YAP overexpression, and HepG2 cells with stable YAP knockdown.	Curcumin	44-52	Yes1 associated transcriptional regulator	Homo sapiens	259-262
34670669-7	2021	Conclusion The combination of curcumin and 5-FU induces autophagy and down-regulates the expression of YAP in hepatocellular carcinoma cells.	Curcumin	30-38	Yes1 associated transcriptional regulator	Homo sapiens	103-106
9168063-4	1997	Curcumin attenuates the levels of MCP-1/JE and IP-10 mRNA expression by all of these stimulatory agents.	Curcumin	0-8	chemokine (C-X-C motif) ligand 10	Mus musculus	47-52
9134658-0	1997	The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa B.	Curcumin	20-28	LOC101909187	Bos taurus	49-62
9134658-3	1997	This study investigates the effect of curcumin on the TNF alpha induced expression of endothelial Tissue Factor (TF), the central mediator of coagulation known to be controlled by AP-1 and NF-kappa B.	Curcumin	38-46	LOC101909187	Bos taurus	98-111
9134658-3	1997	This study investigates the effect of curcumin on the TNF alpha induced expression of endothelial Tissue Factor (TF), the central mediator of coagulation known to be controlled by AP-1 and NF-kappa B.	Curcumin	38-46	LOC101909187	Bos taurus	113-115
9134658-4	1997	When bovine aortic endothelial cells (BAEC) were preincubated in the presence of curcumin, TNF alpha induced TF gene transcription and expression were reduced.	Curcumin	81-89	LOC101909187	Bos taurus	109-111
9134658-5	1997	Transient transfection studies with TF-promoter plasmids revealed that both, NF-kappa B and AP-1 dependent TF expression, were reduced by curcumin action.	Curcumin	138-146	LOC101909187	Bos taurus	36-38
9134658-5	1997	Transient transfection studies with TF-promoter plasmids revealed that both, NF-kappa B and AP-1 dependent TF expression, were reduced by curcumin action.	Curcumin	138-146	LOC101909187	Bos taurus	107-109
8769830-10	1996	Transfection of mesangial cells with a c-jun antisense cDNA and treatment with a pharmacological inhibitor of c-Jun/ AP-1, curcumin, revealed that the induction of c-Jun/AP-1 is essential for the expression of MMP-9 by IL-1 beta.	Curcumin	123-131	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-121
8769830-10	1996	Transfection of mesangial cells with a c-jun antisense cDNA and treatment with a pharmacological inhibitor of c-Jun/ AP-1, curcumin, revealed that the induction of c-Jun/AP-1 is essential for the expression of MMP-9 by IL-1 beta.	Curcumin	123-131	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	170-174
7559628-4	1995	Treatment of human myeloid ML-1a cells with tumor necrosis factor (TNF) rapidly activated NF-kappa B, which consists of p50 and p65 subunits, and this activation was inhibited by curcumin.	Curcumin	179-187	RELA proto-oncogene, NF-kB subunit	Homo sapiens	128-131
7602115-5	1995	Curcumin, a specific inhibitor of c-jun/AP-1, inhibited the cytokine-induced c-jun gene expression in a dose-dependent manner, though the c-fos gene expression was not affected.	Curcumin	0-8	jun proto-oncogene	Mus musculus	34-39
7602115-5	1995	Curcumin, a specific inhibitor of c-jun/AP-1, inhibited the cytokine-induced c-jun gene expression in a dose-dependent manner, though the c-fos gene expression was not affected.	Curcumin	0-8	jun proto-oncogene	Mus musculus	40-44
7602115-5	1995	Curcumin, a specific inhibitor of c-jun/AP-1, inhibited the cytokine-induced c-jun gene expression in a dose-dependent manner, though the c-fos gene expression was not affected.	Curcumin	0-8	jun proto-oncogene	Mus musculus	77-82
7602115-6	1995	TGF-beta 1 stimulated transcriptionally the JE/MCP-1 gene expression, and this stimulation was inhibited significantly by curcumin.	Curcumin	122-130	transforming growth factor, beta 1	Mus musculus	0-10
7602115-8	1995	Curcumin markedly inhibited AP-1 binding activity to 12-tetradecanoyl phorbol-13-acetate-responsive element (TRE) in the cytokine-treated cells.	Curcumin	0-8	jun proto-oncogene	Mus musculus	28-32
7954373-0	1994	Curcumin inhibits TPA induced expression of c-fos, c-jun and c-myc proto-oncogenes messenger RNAs in mouse skin.	Curcumin	0-8	jun proto-oncogene	Mus musculus	51-56
7954373-7	1994	In the present studies, we investigated the effect of curcumin on the expression of c-fos, c-jun and c-myc oncogenes in TPA-treated mouse skin in CD-1 mice.	Curcumin	54-62	jun proto-oncogene	Mus musculus	91-96
7954373-11	1994	A dose of 10 mumol of curcumin was found to inhibit 90% TPA-induced expression of c-fos and c-jun, and 60% of c-myc.	Curcumin	22-30	jun proto-oncogene	Mus musculus	92-97
7955078-14	1994	Application of 10 mumol curcumin to mouse skin twice a day for 5 days immediately after UVB exposure had only a small/variable inhibitory effect on UVB-induced increases in the expression of c-Fos and c-Jun and on epidermal hyperplasia.	Curcumin	24-32	jun proto-oncogene	Mus musculus	201-206
1905019-3	1991	Suppression of the c-Jun/AP-1 activation by curcumin is observed in mouse fibroblast cells.	Curcumin	44-52	jun proto-oncogene	Mus musculus	19-24
1905019-3	1991	Suppression of the c-Jun/AP-1 activation by curcumin is observed in mouse fibroblast cells.	Curcumin	44-52	jun proto-oncogene	Mus musculus	25-29
1905019-4	1991	In vitro experiments indicate that inhibition of c-Jun/AP-1 binding to its cognate motif by curcumin may be responsible for the inhibition of c-Jun/AP-1-mediated gene expression.	Curcumin	92-100	jun proto-oncogene	Mus musculus	49-54
1905019-4	1991	In vitro experiments indicate that inhibition of c-Jun/AP-1 binding to its cognate motif by curcumin may be responsible for the inhibition of c-Jun/AP-1-mediated gene expression.	Curcumin	92-100	jun proto-oncogene	Mus musculus	55-59
1905019-4	1991	In vitro experiments indicate that inhibition of c-Jun/AP-1 binding to its cognate motif by curcumin may be responsible for the inhibition of c-Jun/AP-1-mediated gene expression.	Curcumin	92-100	jun proto-oncogene	Mus musculus	142-147
1905019-4	1991	In vitro experiments indicate that inhibition of c-Jun/AP-1 binding to its cognate motif by curcumin may be responsible for the inhibition of c-Jun/AP-1-mediated gene expression.	Curcumin	92-100	jun proto-oncogene	Mus musculus	148-152
33805981-6	2021	To demonstrate the central role of p65 in these two processes, we used small-molecular inhibitors of p65, such as JSH-23, MG-132 and curcumin.	Curcumin	133-141	RELA proto-oncogene, NF-kB subunit	Homo sapiens	35-38
33000266-12	2020	Additionally, the mRNA and protein levels of apoptosis-associated proteins (Fas, FADD, caspase-8 and caspase-3) and E-cadherin in HCT-116 cells were upregulated following treatment with curcumin in a dose-dependent manner.	Curcumin	186-194	caspase 8	Homo sapiens	87-96
29058812-0	2018	The effects of Curcumin on HCT-116 cells proliferation and apoptosis via the miR-491/PEG10 pathway.	Curcumin	15-23	microRNA 491	Homo sapiens	77-84
29058812-5	2018	Meanwhile, the impaction of Curcumin on miR-491, PEG10, and Wnt/beta-catenin signaling pathway were analyzed in HCT-116 cells.	Curcumin	28-36	microRNA 491	Homo sapiens	40-47
29058812-10	2018	In addition, Curcumin could up-regulate miR-491, inhibit PEG10, and Wnt/beta-catenin signaling pathway.	Curcumin	13-21	microRNA 491	Homo sapiens	40-47
29058812-11	2018	Consequently, Curcumin reduced HCT-116 cells proliferation and promoted cells apoptosis via the miR-491/PEG10 pathway.	Curcumin	14-22	microRNA 491	Homo sapiens	96-103
29058812-12	2018	In conclusion, PEG10 was a target gene of miR-491, miR-491/PEG10 strengthen the sensitivity of Curcumin in HCT-116 cells proliferation and apoptosis, which might act as an ideal diagnostic biomarker treatment methods.	Curcumin	95-103	microRNA 491	Homo sapiens	42-49
29058812-12	2018	In conclusion, PEG10 was a target gene of miR-491, miR-491/PEG10 strengthen the sensitivity of Curcumin in HCT-116 cells proliferation and apoptosis, which might act as an ideal diagnostic biomarker treatment methods.	Curcumin	95-103	microRNA 491	Homo sapiens	51-58
34775900-0	2022	Curcumin deactivates M2 macrophages to alleviate lung fibrosis in IgG4-related disease through activating the toll-like receptor 9 pathway.	Curcumin	0-8	toll like receptor 9	Homo sapiens	110-130
34775900-11	2022	The TLR9 pathway was inhibited in IgG4-RD lung tissues, and Curcumin activated this pathway and reduced macrophage M2 polarization.	Curcumin	60-68	toll like receptor 9	Homo sapiens	4-8
34775900-13	2022	CONCLUSIONS: Curcumin inhibited the occurrence of pulmonary fibrosis in IgG4-RD by inhibiting the TLR9 signaling pathway-mediated macrophage M2 polarization.	Curcumin	13-21	toll like receptor 9	Homo sapiens	98-102
34543634-6	2022	RESULTS: After 2 months, curcumin-age had significantly higher cardiac VEGF-A and NF-kappaB and lower cardiac TSP-1 expression levels in comparison with age and young.	Curcumin	25-33	thrombospondin 1	Rattus norvegicus	110-115
34931590-5	2022	Curcumin effectively upregulated the change rate of mouse weight, colonic length, down-regulated colonic weight, index of colonic weight, colonic damage score and the levels of pro-inflammatory cytokines IL-6, IL-12, IL-23 and TGF-(Formula: see text)1 in colonic tissues of colitis mice.	Curcumin	0-8	interleukin 23, alpha subunit p19	Mus musculus	217-222
34931590-7	2022	In addition, curcumin inhibited the expression of Tfh-related transcription factors BCL-6, p-STAT3, Foxp1, Roquin-1, Roquin-2 and SAP, and significantly upregulated the protein levels of Blimp-1 and STAT3 in colon tissue.	Curcumin	13-21	ring finger and CCCH-type zinc finger domains 2	Mus musculus	117-125
34931590-7	2022	In addition, curcumin inhibited the expression of Tfh-related transcription factors BCL-6, p-STAT3, Foxp1, Roquin-1, Roquin-2 and SAP, and significantly upregulated the protein levels of Blimp-1 and STAT3 in colon tissue.	Curcumin	13-21	PR domain containing 1, with ZNF domain	Mus musculus	187-194
34847213-4	2021	Summarized findings suggest that curcumin supplementation can significantly reduce blood glucose and triglycerides levels, including markers of liver function like alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in patients with T2D and NAFLD.	Curcumin	33-41	glutamic--pyruvic transaminase	Homo sapiens	164-188
34174648-7	2021	Besides, the encapsulation changed the crystalline state of curcumin to amorphous, and the pH-driven mechanism was probably related to hydrogen bonding, hydrophobic and electrostatic interactions.	Curcumin	60-68	phenylalanine hydroxylase	Homo sapiens	91-93
34463926-0	2021	Curcumin Sensitizes Prolactinoma Cells to Bromocriptine by Activating the ERK/EGR1 and Inhibiting the AKT/GSK-3beta Signaling Pathway In Vitro and In Vivo.	Curcumin	0-8	glycogen synthase kinase 3 alpha	Rattus norvegicus	106-115
34401962-0	2021	Curcumin Alleviates Abeta42-Induced Neuronal Metabolic Dysfunction via the Thrb/SIRT3 Axis and Improves Cognition in APPTG Mice.	Curcumin	0-8	thyroid hormone receptor beta	Mus musculus	75-79
34401962-6	2021	Curcumin significantly reversed the inhibitory effects of Abeta42 on cell viability, SIRT3 deacetylation activity, the ratio of NAD+/NADH, ATP level and the protein expression of Thrb and SIRT3, and the promotive effect on apoptosis.	Curcumin	0-8	thyroid hormone receptor beta	Mus musculus	179-183
34401962-10	2021	Moreover, Thrb silence or 3-TYP (a selective inhibitor of SIRT3) treatment abolished the amelioration of curcumin on Abeta42 induced metabolic dysfunction.	Curcumin	105-113	thyroid hormone receptor beta	Mus musculus	10-14
34401962-12	2021	Collectively, curcumin alleviated Abeta42-induced neuronal metabolic dysfunction through increasing Thrb expression and SIRT3 activity and improved cognition in APPTG mice.	Curcumin	14-22	thyroid hormone receptor beta	Mus musculus	100-104
34825004-13	2021	It was concluded that curcumin administered in combination with Glu-GNPs and X-ray irradiation could reduce the protein expression of VEGF, HSP90, HIF-1alpha, and MMP9 in tumor tissue when compared with the model group.	Curcumin	22-30	heat shock protein 86, pseudogene 1	Mus musculus	140-145
34825004-13	2021	It was concluded that curcumin administered in combination with Glu-GNPs and X-ray irradiation could reduce the protein expression of VEGF, HSP90, HIF-1alpha, and MMP9 in tumor tissue when compared with the model group.	Curcumin	22-30	matrix metallopeptidase 9	Mus musculus	163-167
34589382-0	2021	Curcumin Alleviates Oxygen-Glucose-Deprivation/Reperfusion-Induced Oxidative Damage by Regulating miR-1287-5p/LONP2 Axis in SH-SY5Y Cells.	Curcumin	0-8	microRNA 1287	Homo sapiens	98-106
34567209-6	2021	Additionally, curcumin significantly downregulated CD11b+F4/80+TLR4+ macrophages and the protein levels of TLR2, TLR4, MyD88, NF-kappaBp65, p38MAPK, and AP-1 in colitis mice.	Curcumin	14-22	toll-like receptor 2	Mus musculus	107-111
34567209-6	2021	Additionally, curcumin significantly downregulated CD11b+F4/80+TLR4+ macrophages and the protein levels of TLR2, TLR4, MyD88, NF-kappaBp65, p38MAPK, and AP-1 in colitis mice.	Curcumin	14-22	mitogen-activated protein kinase 14	Mus musculus	140-147
34567209-6	2021	Additionally, curcumin significantly downregulated CD11b+F4/80+TLR4+ macrophages and the protein levels of TLR2, TLR4, MyD88, NF-kappaBp65, p38MAPK, and AP-1 in colitis mice.	Curcumin	14-22	jun proto-oncogene	Mus musculus	153-157
34216673-2	2021	In this study, chitosan-magnetite-reduced graphene oxide (CS-Fe3O4-RGO) nanocomposites (NC) were used for the targeted delivery of curcumin (Cur) as anticancer drugs to suppress MCF-7 breast cancer cells and this was accomplished using a facile water-in-oil (W/O) emulsification procedure.	Curcumin	131-139	citrate synthase	Homo sapiens	58-60
34216673-2	2021	In this study, chitosan-magnetite-reduced graphene oxide (CS-Fe3O4-RGO) nanocomposites (NC) were used for the targeted delivery of curcumin (Cur) as anticancer drugs to suppress MCF-7 breast cancer cells and this was accomplished using a facile water-in-oil (W/O) emulsification procedure.	Curcumin	141-144	citrate synthase	Homo sapiens	58-60
34448459-5	2021	Results showed that curcumin significantly decreased renal apoptosis and caspase-3/-9 expression and enhanced renal function in IRI rats.	Curcumin	20-28	caspase 3	Rattus norvegicus	73-85
34448459-7	2021	Reduced histone H3 lysine 9 (H3K9) acetylation was found near the promoter region of caspase-3/-9 after curcumin treatment.	Curcumin	104-112	caspase 3	Rattus norvegicus	85-97
34448459-9	2021	In addition, SP600125 suppressed the binding level of p300/CBP and H3K9 acetylation near the promoter region of caspase-3/-9, and curcumin could inhibit JNK phosphorylation like SP600125.	Curcumin	130-138	caspase 3	Rattus norvegicus	112-124
24165291-0	2013	Curcumin suppresses malignant glioma cells growth and induces apoptosis by inhibition of SHH/GLI1 signaling pathway in vitro and vivo.	Curcumin	0-8	GLI-Kruppel family member GLI1	Mus musculus	93-97
24165291-1	2013	AIMS: To study the role of curcumin on glioma cells via the SHH/GLI1 pathway in vitro and vivo.	Curcumin	27-35	GLI-Kruppel family member GLI1	Mus musculus	64-68
24165291-7	2013	Curcumin treatment prevented GLI1 translocating into the cell nucleus and reduced the concentration of its reporter.	Curcumin	0-8	GLI-Kruppel family member GLI1	Mus musculus	29-33
34471643-9	2021	Overall, our findings demonstrated that curcumin alleviates endothelial lipotoxicity and LOX-1 upregulation, and ER stress inhibition may play a critical role in this effect.	Curcumin	40-48	oxidized low density lipoprotein receptor 1	Homo sapiens	89-94
34784955-0	2021	Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis.	Curcumin	0-8	microRNA 320a	Homo sapiens	72-80
34784955-15	2021	CONCLUSION: Curcumin restrained proliferation and facilitated apoptosis in ovarian cancer by regulating the circ-PLEKHM3/miR-320a/SMG1 axis.	Curcumin	12-20	microRNA 320a	Homo sapiens	121-129
23978416-0	2013	Curcumin analogue identified as hyaluronan export inhibitor by virtual docking to the ABC transporter MRP5.	Curcumin	0-8	ATP binding cassette subfamily C member 5	Homo sapiens	102-106
34758851-17	2021	Furthermore, in vitro and in vivo results showed that curcumin induced cell apoptosis, and had anti-angiogenesis and anti-tumorigenesis effects as a result of activating the GSK-3beta/beta-TrCP ubiquitination pathway and subsequent decrease in Nrf2.	Curcumin	54-62	glycogen synthase kinase 3 alpha	Homo sapiens	174-183
34592487-6	2021	Flow cytometry were used to analyze the effects of Curcumin on the expression of programmed cell death protein 1 (PD-1) and T-cell immunoglobulin and mucin-domain3 (TIM-3) on CD4, CD8 and Treg.	Curcumin	51-59	programmed cell death 1	Sus scrofa	81-112
34592487-11	2021	Curcumin increased T-cell proliferation, tumor-infiltrating lymphocytes (TILs), and effector cytokines, and decreased the expression of PD-1, TIM-3, suppressive IC receptors and their ligands (PD-L1, PD-L2, and Galectin-9) in the TME, implying reinvigoration of the exhausted CD8+ T cells.	Curcumin	0-8	hepatitis A virus cellular receptor 2	Mus musculus	142-147
34657625-3	2021	This study investigated whether curcumin regulates transforming growth factor (TGF)-beta1, type I TGF-beta receptor (TGF-betaRI), type II TGF-beta receptor (TGF-betaRII), and vascular endothelial growth factor (VEGF) expression in unwounded hGFs and an in vitro hGF wound healing model.	Curcumin	32-40	transforming growth factor beta receptor 2	Homo sapiens	157-168
34657625-11	2021	PD98059 significantly attenuated the curcumin-stimulated TGF-betaRI, TGF-betaRII, and VEGF expression, whereas it had no effect on TGF-beta1 expression.	Curcumin	37-45	transforming growth factor beta receptor 2	Homo sapiens	69-80
34657625-12	2021	CONCLUSIONS: Curcumin upregulated TGF-beta1, TGF-betaRI, TGF-betaRII, and VEGF expression in an in vitro hGF wound healing model.	Curcumin	13-21	transforming growth factor beta receptor 2	Homo sapiens	57-68
34657625-12	2021	CONCLUSIONS: Curcumin upregulated TGF-beta1, TGF-betaRI, TGF-betaRII, and VEGF expression in an in vitro hGF wound healing model.	Curcumin	13-21	hepatocyte growth factor	Homo sapiens	105-108
34657625-13	2021	The ERK pathway is required for TGF-betaRI, TGF-betaRII, and VEGF induction by curcumin.	Curcumin	79-87	transforming growth factor beta receptor 2	Homo sapiens	44-55
34453990-9	2021	In addition, curcumin treatment also activated G protein-coupled receptor 43 (GPR 43) in the PVN.	Curcumin	13-21	free fatty acid receptor 2	Rattus norvegicus	47-76
34453990-9	2021	In addition, curcumin treatment also activated G protein-coupled receptor 43 (GPR 43) in the PVN.	Curcumin	13-21	free fatty acid receptor 2	Rattus norvegicus	78-84
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	Curcumin	298-306	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	46-51
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	Curcumin	298-306	angiotensin converting enzyme 2	Homo sapiens	225-229
34481181-10	2021	RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry.	Curcumin	40-48	angiotensin converting enzyme 2	Homo sapiens	87-91
34481181-10	2021	RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry.	Curcumin	40-48	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	101-106
34481181-10	2021	RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry.	Curcumin	40-48	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	120-125
34481181-10	2021	RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry.	Curcumin	40-48	angiotensin converting enzyme 2	Homo sapiens	126-130
34481181-13	2021	CONCLUSION: This result provides a significant insight about the phytochemicals" role, namely curcumin and piperine, as the potential therapeutic entities against mutated spike protein of SARS-CoV-2.	Curcumin	94-102	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	171-176
34630845-6	2021	Furthermore, curcumin significantly reduced the number of gasdermin D+ (GSDMD+) Iba1+ and caspase-1+Iba1+ microglia/macrophage 21 days after stroke.	Curcumin	13-21	caspase 1	Mus musculus	90-99
34630845-8	2021	Western blot revealed a decrease in pyroptosis-related proteins, e.g., GSDMD-N, cleaved caspase-1, NLRP3, IL-1beta, and IL-18, following in vitro or in vivo curcumin treatment.	Curcumin	157-165	caspase 1	Mus musculus	88-97
34630845-8	2021	Western blot revealed a decrease in pyroptosis-related proteins, e.g., GSDMD-N, cleaved caspase-1, NLRP3, IL-1beta, and IL-18, following in vitro or in vivo curcumin treatment.	Curcumin	157-165	interleukin 18	Mus musculus	120-125
34323243-5	2021	In the present study, curcumin, a natural polyphenolic compound, was found to re-induce cell differentiation and increase the expression of thyroid-specific transcription factors, TTF-1, TTF-2 and transcriptional factor paired box 8 (PAX8), and iodide-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase (TPO) and sodium iodide symporter (NIS) in dedifferentiated thyroid cancer cell lines, BCPAP and KTC-1.	Curcumin	22-30	transcription termination factor 1	Homo sapiens	180-185
34323243-5	2021	In the present study, curcumin, a natural polyphenolic compound, was found to re-induce cell differentiation and increase the expression of thyroid-specific transcription factors, TTF-1, TTF-2 and transcriptional factor paired box 8 (PAX8), and iodide-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase (TPO) and sodium iodide symporter (NIS) in dedifferentiated thyroid cancer cell lines, BCPAP and KTC-1.	Curcumin	22-30	paired box 8	Homo sapiens	220-232
34323243-5	2021	In the present study, curcumin, a natural polyphenolic compound, was found to re-induce cell differentiation and increase the expression of thyroid-specific transcription factors, TTF-1, TTF-2 and transcriptional factor paired box 8 (PAX8), and iodide-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase (TPO) and sodium iodide symporter (NIS) in dedifferentiated thyroid cancer cell lines, BCPAP and KTC-1.	Curcumin	22-30	paired box 8	Homo sapiens	234-238
34159801-10	2021	Immunohistochemistry for FABP4, a major regulator of PPARg pathway showed a decreased FABP4+ alveolar cell density in LPD-exposed animals treated by curcumin.	Curcumin	149-157	fatty acid binding protein 4	Rattus norvegicus	25-30
34159801-10	2021	Immunohistochemistry for FABP4, a major regulator of PPARg pathway showed a decreased FABP4+ alveolar cell density in LPD-exposed animals treated by curcumin.	Curcumin	149-157	fatty acid binding protein 4	Rattus norvegicus	86-91
34352168-0	2021	Protective effects of curcumin against methotrexate-induced testicular damage in rats by suppression of the p38-MAPK and nuclear factor-kappa B pathways.	Curcumin	22-30	mitogen activated protein kinase 14	Rattus norvegicus	108-116
34352168-1	2021	Objective: The present study aimed to investigate the possibility that curcumin (CMN) protects against methotrexate (MTX)-induced testicular damage by affecting the phospho-p38 (p-p38) mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappaB) signaling pathways.	Curcumin	71-79	mitogen activated protein kinase 14	Rattus norvegicus	173-176
34352168-1	2021	Objective: The present study aimed to investigate the possibility that curcumin (CMN) protects against methotrexate (MTX)-induced testicular damage by affecting the phospho-p38 (p-p38) mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappaB) signaling pathways.	Curcumin	71-79	mitogen activated protein kinase 14	Rattus norvegicus	180-183
34352168-1	2021	Objective: The present study aimed to investigate the possibility that curcumin (CMN) protects against methotrexate (MTX)-induced testicular damage by affecting the phospho-p38 (p-p38) mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappaB) signaling pathways.	Curcumin	81-84	mitogen activated protein kinase 14	Rattus norvegicus	173-176
34352168-1	2021	Objective: The present study aimed to investigate the possibility that curcumin (CMN) protects against methotrexate (MTX)-induced testicular damage by affecting the phospho-p38 (p-p38) mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappaB) signaling pathways.	Curcumin	81-84	mitogen activated protein kinase 14	Rattus norvegicus	180-183
34405526-0	2021	Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-kappaB signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus.	Curcumin	0-8	high mobility group box 1	Mus musculus	48-53
34405526-8	2021	Additionally, curcumin treatment could effectively decrease HMGB1 protein expression, advanced glycosylation end product-specific receptor (RAGE), Toll-like receptors-4 (TLR4) and nuclear factor kappa B (NF-kappaB) in transgenic mice hippocampus.	Curcumin	14-22	high mobility group box 1	Mus musculus	60-65
34405526-11	2021	Taken together, these data indicate that oral administration of curcumin may be a promising agent to attenuate memory deterioration in AD mice, probably inhibiting the HMGB1-RAGE/TLR4-NF-kappaB inflammatory signalling pathway.	Curcumin	64-72	high mobility group box 1	Mus musculus	168-173
34572508-0	2021	Curcumin Reverses NNMT-Induced 5-Fluorouracil Resistance via Increasing ROS and Cell Cycle Arrest in Colorectal Cancer Cells.	Curcumin	0-8	nicotinamide N-methyltransferase	Homo sapiens	18-22
34577580-6	2021	Our network and pathway analyses implicated the four targets of AKT1, RELA, MAPK1, and TP53 that could be involved in the inhibitory effects of curcumin on influenza.	Curcumin	144-152	RELA proto-oncogene, NF-kB subunit	Homo sapiens	70-74
34408780-8	2021	In conclusion, curcumin inhibits HGF-induced EMT by targeting c-MET and subsequently blocking the PI3K/Akt/mTOR pathway.	Curcumin	15-23	hepatocyte growth factor	Homo sapiens	33-36
34355287-5	2021	METHODS: The effect of curcumin and BDMC-A on transcription factors (NF-kappaB, p65, c-Jun, c-Fos, STAT3, 5, PPAR-gamma, beta-catenin, COX-2, MMP-9, VEGF, TIMP-2) involved in signal transduction cascade, invasion, and angiogenesis in Hep-2 cells were quantified using Western blotting and RT-PCR technique.	Curcumin	23-31	RELA proto-oncogene, NF-kB subunit	Homo sapiens	80-83
34565029-0	2021	Curcumin inhibits proliferation and invasion of papillary thyroid carcinoma cells by inhibiting the JAK2 / STAT3 pathway.	Curcumin	0-8	Janus kinase 2	Homo sapiens	100-104
34565029-1	2021	PURPOSE: The purpose of this study was to analyze the function of curcumin to suppress the proliferative and invasive abilities of papillary thyroid carcinoma (PTC) through inhibiting the JAK2/STAT3 pathway.	Curcumin	66-74	Janus kinase 2	Homo sapiens	188-192
34565029-3	2021	Western blot analyses were performed to detect protein levels of apoptosis-associated genes, JAK2 and STAT3 in TPC-1 and SW1736 cells treated with different doses of curcumin.	Curcumin	166-174	Janus kinase 2	Homo sapiens	93-97
34189639-2	2021	Curcumin was employed as an inhibitor of the efflux transporter, multidrug resistance protein 5 (MRP5) in PDAC cells.	Curcumin	0-8	ATP binding cassette subfamily C member 5	Homo sapiens	65-95
34189639-2	2021	Curcumin was employed as an inhibitor of the efflux transporter, multidrug resistance protein 5 (MRP5) in PDAC cells.	Curcumin	0-8	ATP binding cassette subfamily C member 5	Homo sapiens	97-101
34189639-10	2021	Additionally, curcumin slightly increase the plasma concentrations of gemcitabine possibly also via the MRP5 inhibition effect.	Curcumin	14-22	ATP binding cassette subfamily C member 5	Homo sapiens	104-108
34350255-9	2021	Results: Curcumin significantly inhibited the IL-1beta-induced reduction of cell viability, degradation of ECM, and the expression of SOX9, Col2alpha, and AGG (P<0.01).	Curcumin	9-17	SRY (sex determining region Y)-box 9	Mus musculus	134-138
34103964-12	2021	Greater numbers of apoptotic cells, lesser expression of p62, p-Akt, and p-mTOR, and greater expression of E2F1, PITX1, and LC3B were observed in the agomir-34a and high-dose curcumin-treated group than in agomir-34a and low-dose curcumin-treated group.	Curcumin	175-183	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	57-60
34121883-4	2021	This study aimed to evaluate the effect of curcumin on the structural changes of the SA node in L-MET-treated rats.	Curcumin	43-51	MET proto-oncogene, receptor tyrosine kinase	Rattus norvegicus	98-101
34121883-12	2021	Furthermore, treatment with curcumin could protect the SA node from cellular decline in the MET + curcumin group (p < 0.01).	Curcumin	98-106	MET proto-oncogene, receptor tyrosine kinase	Rattus norvegicus	92-95
34159091-5	2021	Results: The serum levels of UN, Cr, NF-kappaB, ALT, AST, amylase, CK, LDH, inflammatory factors TNF-alpha and IL-10, and markers of early diagnosis of SAKI (NGAL, CysC, KIM-1) were significantly lower in the curcumin group than those in the placebo group (P<0.05).	Curcumin	209-217	lipocalin 2	Rattus norvegicus	158-162
34272350-1	2021	To determine whether curcumin (Cur) can treat mice with experimentally-induced colitis by regulating follicular helper T cells (Tfh) and follicular regulatory T cells (Tfr) by inhibiting interleukin (IL)-21.	Curcumin	21-29	transferrin receptor	Mus musculus	168-171
34272350-9	2021	Curcumin may have a potential therapeutic effect on mice with colitis treated experimentally through regulation of the balance of Tfh and Tfr cells via inhibiting the synthesis of IL-21.	Curcumin	0-8	transferrin receptor	Mus musculus	138-141
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Curcumin	169-177	C-C motif chemokine ligand 3	Rattus norvegicus	85-95
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Curcumin	341-349	C-C motif chemokine ligand 3	Rattus norvegicus	85-95
34462629-6	2021	In vitro, curcumin decreased LPS/IFNgamma-elevated M1 macrophage marker (iNOS and CD86) expression and the proportion of M1 macrophages (iNOS+F4/80+ cells) but increased LPS/IFNgamma-suppressed M2 macrophage marker (Arg1 and CD206) expression and the proportion of M2 macrophages (Arg1+F4/80+ cells).	Curcumin	10-18	arginase, liver	Mus musculus	216-220
34462629-6	2021	In vitro, curcumin decreased LPS/IFNgamma-elevated M1 macrophage marker (iNOS and CD86) expression and the proportion of M1 macrophages (iNOS+F4/80+ cells) but increased LPS/IFNgamma-suppressed M2 macrophage marker (Arg1 and CD206) expression and the proportion of M2 macrophages (Arg1+F4/80+ cells).	Curcumin	10-18	arginase, liver	Mus musculus	281-285
34323067-5	2021	Curcumin profoundly attenuated OPA- or HFHFD-induced hyperlipidemia and aberrant hepatic lipid deposition via modulating the expression and function of SLC13A5 and ACLY.	Curcumin	0-8	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	152-159
34323067-5	2021	Curcumin profoundly attenuated OPA- or HFHFD-induced hyperlipidemia and aberrant hepatic lipid deposition via modulating the expression and function of SLC13A5 and ACLY.	Curcumin	0-8	ATP citrate lyase	Mus musculus	164-168
34323067-7	2021	In OPA-stimulated HepG2 cells, curcumin rectified the dysregulated expression of SLC13A5/ACLY possibly via the AMPK-mTOR signaling pathway.	Curcumin	31-39	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	111-115
34408780-0	2021	Curcumin Inhibits HGF-Induced EMT by Regulating c-MET-Dependent PI3K/Akt/mTOR Signaling Pathways in Meningioma.	Curcumin	0-8	hepatocyte growth factor	Homo sapiens	18-21
34324434-0	2021	Curcumin in combination with homoharringtonine suppresses lymphoma cell growth by inhibiting the TGF-beta/Smad3 signaling pathway.	Curcumin	0-8	transforming growth factor alpha	Homo sapiens	97-105
34324434-0	2021	Curcumin in combination with homoharringtonine suppresses lymphoma cell growth by inhibiting the TGF-beta/Smad3 signaling pathway.	Curcumin	0-8	SMAD family member 3	Homo sapiens	106-111
34324434-9	2021	Our findings indicate that combination of HHT and curcumin inhibited lymphoma cell growth by downregulating the TGF-beta/Smad3 pathway.	Curcumin	50-58	transforming growth factor alpha	Homo sapiens	112-120
34324434-9	2021	Our findings indicate that combination of HHT and curcumin inhibited lymphoma cell growth by downregulating the TGF-beta/Smad3 pathway.	Curcumin	50-58	SMAD family member 3	Mus musculus	121-126
34202024-5	2021	Orbital fibroblasts from one healthy donor and three patients with GO were collected for primary cell culture and subjected to myofibroblast differentiation under the administration of 1 or 5 ng/mL TGF-beta1 for 24 h. The effects of curcumin on TGF-beta1-induced orbital fibroblasts were assessed by measuring the cellular viability and detecting the expression of myofibroblast differentiation markers, including connective tissue growth factor (CTGF) and alpha-smooth muscle actin (alpha-SMA).	Curcumin	233-241	cellular communication network factor 2	Homo sapiens	414-445
34202024-7	2021	Treatment of orbital fibroblasts with curcumin inhibited the TGF-beta1 signaling pathway and attenuated the expression of CTGF and alpha-SMA induced by TGF-beta1.	Curcumin	38-46	cellular communication network factor 2	Homo sapiens	122-126
34138966-5	2021	Here, we provide experimental evidence that, among 56 tested polyphenols, including plant extracts, brazilin, theaflavin-3,3"-digallate, and curcumin displayed the highest binding with the receptor-binding domain of spike protein, inhibiting viral attachment to the human angiotensin-converting enzyme 2 receptor, and thus cellular entry of pseudo-typed SARS-CoV-2 virions.	Curcumin	141-149	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	216-221
34095193-6	2021	Several BACs such as omega-3 fatty acid, curcumin, vitamins, essential oils, antimicrobials, and probiotic bacteria can be encapsulated which exhibit immunological activity through different mechanisms.	Curcumin	41-49	bacs	None	8-12
34134960-6	2021	The results of Western blotting showed that curcumin also concentration-dependently increased the cellular expressions of caspase-3, caspase-9 and Bax and lowered the expressions of Bcl-2, cyclin B1, CDK1 and beta-catenin along with the downstream proteins cyclin D1 and c-myc in the Wnt/beta-catenin signaling pathway (P < 0.05).	Curcumin	44-52	cyclin D1	Homo sapiens	257-266
34109908-0	2021	Curcumin Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting NLRP1-dependent Neuronal Pyroptosis.	Curcumin	0-8	NLR family, pyrin domain containing 1A	Rattus norvegicus	71-76
34109908-6	2021	The results of western blotting showed that curcumin down-regulated the expression of nucleotide-binding oligomerization domain-containing protein-, leucine-rich repeats-, and pyrin domain-containing protein 1 (NLRP1), cysteinyl aspartate-specific protease 1 (caspase-1), gasdermin D (GSDMD), IL-1beta, IL-6, TNF-alpha, and iNOS proteins in OGD and MCAO models.	Curcumin	44-52	NLR family, pyrin domain containing 1A	Rattus norvegicus	211-216
34284543-0	2021	Curcumin promotes the proliferation, invasion of neural stem cells and formation of neurospheres via activating SDF-1/CXCR4 axis.	Curcumin	0-8	C-X-C motif chemokine ligand 12	Rattus norvegicus	112-117
34284543-7	2021	In addition, Curcumin up-regulated the expression of SDF-1 and promoted the formation of SDF-1/CXCR4 complex in NSCs.	Curcumin	13-21	C-X-C motif chemokine ligand 12	Rattus norvegicus	53-58
34284543-7	2021	In addition, Curcumin up-regulated the expression of SDF-1 and promoted the formation of SDF-1/CXCR4 complex in NSCs.	Curcumin	13-21	C-X-C motif chemokine ligand 12	Rattus norvegicus	89-94
34284543-10	2021	These results suggested that curcumin promoted the NSCs proliferation, migration and formation of neurospheres via SDF-1/CXCR4 in NSCs.	Curcumin	29-37	C-X-C motif chemokine ligand 12	Rattus norvegicus	115-120
35490921-9	2022	Curcumin prevented the change of expression of 13 proteins involved in oxidative phosphorylation (NDUFB8, NDUFB3, and ATP5L) in the cellular response to stress (PSMA5, HIST1H1D) and lipid metabolism (THRSP, DGAT1, ECI1, and ACOT13).	Curcumin	0-8	NADH:ubiquinone oxidoreductase subunit B8	Mus musculus	98-104
35621145-6	2022	The experimental models revealed that curcumin abrogated the CAF-mediated activation of the JAK/STAT3 signaling pathway in GC cells.	Curcumin	38-46	lysine acetyltransferase 2B	Homo sapiens	61-64
35549905-0	2022	Peroxiredoxin 6 mediates the protective function of curcumin pretreatment in acute lung injury induced by serum from patients undergoing one-lung ventilation in vitro.	Curcumin	52-60	peroxiredoxin 6	Homo sapiens	0-15
35549905-9	2022	Pretreatment with curcumin restored Prdx6 downregulation and inhibited NF-kappaB pathway activation by suppressing the nuclear translocation of P65, eventually reducing inflammation and oxidative stress damage in A549 cells.	Curcumin	18-26	peroxiredoxin 6	Homo sapiens	36-41
35549905-9	2022	Pretreatment with curcumin restored Prdx6 downregulation and inhibited NF-kappaB pathway activation by suppressing the nuclear translocation of P65, eventually reducing inflammation and oxidative stress damage in A549 cells.	Curcumin	18-26	RELA proto-oncogene, NF-kB subunit	Homo sapiens	144-147
35549905-10	2022	CONCLUSIONS: Prdx6 mediated the protective function of curcumin by inhibiting the activation of the NF-kappaB pathway in ALI in vitro.	Curcumin	55-63	peroxiredoxin 6	Homo sapiens	13-18
23978416-2	2013	Hyaluronan is exported from fibroblasts by the multidrug resistance associated protein 5 (MRP5) which is inhibited by the plant phenols curcumin or xanthohumol.	Curcumin	136-144	ATP binding cassette subfamily C member 5	Homo sapiens	47-88
23978416-2	2013	Hyaluronan is exported from fibroblasts by the multidrug resistance associated protein 5 (MRP5) which is inhibited by the plant phenols curcumin or xanthohumol.	Curcumin	136-144	ATP binding cassette subfamily C member 5	Homo sapiens	90-94
24144778-0	2013	Curcumin induces radiosensitivity of in vitro and in vivo cancer models by modulating pre-mRNA processing factor 4 (Prp4).	Curcumin	0-8	pre-mRNA processing factor 4	Homo sapiens	86-114
35538560-0	2022	Curcumin ameliorates the experimental diabetic peripheral neuropathy through promotion of NGF expression in rats.	Curcumin	0-8	nerve growth factor	Rattus norvegicus	90-93
35538560-16	2022	In addition, curcumin at 150 mg/kg had the best efficacy in increasing protein expression of NGF in sciatic nerves and serum NGF level.	Curcumin	13-21	nerve growth factor	Rattus norvegicus	93-96
35538560-16	2022	In addition, curcumin at 150 mg/kg had the best efficacy in increasing protein expression of NGF in sciatic nerves and serum NGF level.	Curcumin	13-21	nerve growth factor	Rattus norvegicus	125-128
35585935-11	2022	Furthermore, curcumin repress the expression of SOX10, Notch1, and HES-1, and increase the expression of miR-222-3p.	Curcumin	13-21	hes family bHLH transcription factor 1	Homo sapiens	67-72
24144778-0	2013	Curcumin induces radiosensitivity of in vitro and in vivo cancer models by modulating pre-mRNA processing factor 4 (Prp4).	Curcumin	0-8	pre-mRNA processing factor 4	Homo sapiens	116-120
35609329-9	2022	Administration with curcumin reversed the CIA-induced increase in arthritis scores, hind paw edema, and loss of appetite, while these effects were rescued by insulin-like growth factor 1, the upstream cytokine of PI3K/AKT.	Curcumin	20-28	insulin-like growth factor 1	Mus musculus	158-186
24223665-0	2013	Curcumin enhances the effectiveness of cisplatin by suppressing CD133+ cancer stem cells in laryngeal carcinoma treatment.	Curcumin	0-8	prominin 1	Homo sapiens	64-69
35122926-4	2022	With the incubation of curcumin (1 muM), 6-OHDA-induced apoptosis was suppressed, increasing the autophagy markers (LC3-II/LC3-I, Beclin-1) and inhibiting phosphor-AKT/AKT, phosphor-mTOR/mTOR.	Curcumin	23-31	beclin 1	Rattus norvegicus	130-138
35508082-0	2022	Curcumin inhibits spike protein of new SARS-CoV-2 variant of concern (VOC) Omicron, an in silico study.	Curcumin	0-8	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	18-23
24223665-2	2013	In the present study, curcumin and cisplatin were used as a combined treatment to induce the sensitivity of CD133+ cancer stem cells to chemotherapeutic agents and to enhance therapeutic effectiveness.	Curcumin	22-30	prominin 1	Homo sapiens	108-113
35508082-4	2022	METHODS: The three-dimensional structure of the Spike RBD domain of Omicron variant was constructed by incorporating 15 amino acid substitutions to the Native Spike (S) structure and structural changes were compared that of the Native S. Seven phytochemicals namely Allicin, Capsaicin, Cinnamaldehyde, Curcumin, Gingerol, Piperine, and Zingeberene were docked with Omicron S protein and Omicron S-hACE2 complex.	Curcumin	302-310	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	48-53
35508082-4	2022	METHODS: The three-dimensional structure of the Spike RBD domain of Omicron variant was constructed by incorporating 15 amino acid substitutions to the Native Spike (S) structure and structural changes were compared that of the Native S. Seven phytochemicals namely Allicin, Capsaicin, Cinnamaldehyde, Curcumin, Gingerol, Piperine, and Zingeberene were docked with Omicron S protein and Omicron S-hACE2 complex.	Curcumin	302-310	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	159-164
35508082-7	2022	Further, it was found that curcumin could disrupt the Omicron S-hACE2 complex.	Curcumin	27-35	angiotensin converting enzyme 2	Homo sapiens	64-69
35564180-6	2022	In an in silico molecular docking study of the gallium-curcumin complex in PDI, calnexin, HSP60, PDK, caspase 9, Akt1 and PTEN were found to be strong binding.	Curcumin	55-63	prolyl 4-hydroxylase subunit beta	Homo sapiens	75-78
24223665-4	2013	However, in the combined treatment group, the percentage of CD133+ cells was markedly reduced to 1.49%, indicating that curcumin may increase the sensitivity of CD133+ cells to cisplatin, leading to the suppression of chemoresistance in HEp-2 cells.	Curcumin	120-128	prominin 1	Homo sapiens	60-65
24223665-4	2013	However, in the combined treatment group, the percentage of CD133+ cells was markedly reduced to 1.49%, indicating that curcumin may increase the sensitivity of CD133+ cells to cisplatin, leading to the suppression of chemoresistance in HEp-2 cells.	Curcumin	120-128	prominin 1	Homo sapiens	161-166
35594716-7	2022	Eight potential phytochemicals were analyzed for GSTM2 promoter activation, and results indicated that baicalein, berberrubine, chalcone, curcumin, resveratrol, and wogonin can increase promoter activity.	Curcumin	138-146	glutathione S-transferase mu 2	Homo sapiens	49-54
24057865-9	2013	The D942 and curcumin induced autophagy in cardiomyocytes through activating AMPK pathway or inhibiting mTOR signaling.	Curcumin	13-21	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	77-81
35621145-9	2022	It is suggested that curcumin may be a suitable natural product which may be used to overcome chemoresistance by inhibiting the CAF-induced activation of the JAK/STAT3 signaling pathway in GC.	Curcumin	21-29	lysine acetyltransferase 2B	Homo sapiens	128-131
35564180-6	2022	In an in silico molecular docking study of the gallium-curcumin complex in PDI, calnexin, HSP60, PDK, caspase 9, Akt1 and PTEN were found to be strong binding.	Curcumin	55-63	calnexin	Homo sapiens	80-88
35259661-5	2022	The present study focused on curcumin derivatives with reliable ADME profile and high molecular binding potency to different SARS-CoV-2 target enzymes (3CLPro, PLpro, NSP7/8/12, NSP7/8/12 +RNA, NSP15, NSP16, Spike, Spike+ACE).	Curcumin	29-37	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	160-165
24036253-0	2013	Curcumin improves expression of ghrelin through attenuating oxidative stress in gastric tissues of streptozotocin-induced diabetic gastroparesis rats.	Curcumin	0-8	ghrelin and obestatin prepropeptide	Rattus norvegicus	32-39
35259661-5	2022	The present study focused on curcumin derivatives with reliable ADME profile and high molecular binding potency to different SARS-CoV-2 target enzymes (3CLPro, PLpro, NSP7/8/12, NSP7/8/12 +RNA, NSP15, NSP16, Spike, Spike+ACE).	Curcumin	29-37	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	167-176
35259661-5	2022	The present study focused on curcumin derivatives with reliable ADME profile and high molecular binding potency to different SARS-CoV-2 target enzymes (3CLPro, PLpro, NSP7/8/12, NSP7/8/12 +RNA, NSP15, NSP16, Spike, Spike+ACE).	Curcumin	29-37	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	178-187
35259661-5	2022	The present study focused on curcumin derivatives with reliable ADME profile and high molecular binding potency to different SARS-CoV-2 target enzymes (3CLPro, PLpro, NSP7/8/12, NSP7/8/12 +RNA, NSP15, NSP16, Spike, Spike+ACE).	Curcumin	29-37	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	208-213
35259661-5	2022	The present study focused on curcumin derivatives with reliable ADME profile and high molecular binding potency to different SARS-CoV-2 target enzymes (3CLPro, PLpro, NSP7/8/12, NSP7/8/12 +RNA, NSP15, NSP16, Spike, Spike+ACE).	Curcumin	29-37	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	215-220
35259661-6	2022	In the molecular docking studies, the best binding scores for the 22 proposed curcumin derivatives were obtained for the PLpro protein.	Curcumin	78-86	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	121-126
35543146-7	2022	Curcumin was observed to inhibit H2O2-induced pyroptosis by inhibiting the activation of NOD-, LRR- and pyrin domain-containing protein 3.	Curcumin	0-8	atrophin 1	Homo sapiens	89-92
35458704-7	2022	Although LPS increased AhR and its target gene CYP1B1, curcumin further enhanced LPS-induced CYP1B1 and indoleamine 2,3-dioxygenase (IDO), which metabolizes tryptophan to AhR ligands kynurenine (KYN) and kynurenic acid (KYNA).	Curcumin	55-63	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	47-53
35458704-7	2022	Although LPS increased AhR and its target gene CYP1B1, curcumin further enhanced LPS-induced CYP1B1 and indoleamine 2,3-dioxygenase (IDO), which metabolizes tryptophan to AhR ligands kynurenine (KYN) and kynurenic acid (KYNA).	Curcumin	55-63	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	93-99
35458704-8	2022	Potential interactions between curcumin and human AhR analyzed by molecular modeling of ligand-receptor docking.	Curcumin	31-39	aryl hydrocarbon receptor	Homo sapiens	50-53
35458704-11	2022	Moreover, curcumin and KYNA collaboratively bound onto AhR during molecular docking, potentially resulting in synergistic effects influencing AhR activation.	Curcumin	10-18	aryl hydrocarbon receptor	Homo sapiens	55-58
35458704-11	2022	Moreover, curcumin and KYNA collaboratively bound onto AhR during molecular docking, potentially resulting in synergistic effects influencing AhR activation.	Curcumin	10-18	aryl hydrocarbon receptor	Homo sapiens	142-145
35458704-12	2022	Curcumin may enhance the inflammation-induced IDO/KYN axis and allosterically regulate endogenous ligand binding to AhR, facilitating AhR activation to regulate inflammatory astrogliosis.	Curcumin	0-8	aryl hydrocarbon receptor	Homo sapiens	116-119
35458704-12	2022	Curcumin may enhance the inflammation-induced IDO/KYN axis and allosterically regulate endogenous ligand binding to AhR, facilitating AhR activation to regulate inflammatory astrogliosis.	Curcumin	0-8	aryl hydrocarbon receptor	Homo sapiens	134-137
35473503-12	2022	Curcumin inhibited the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway.	Curcumin	0-8	Janus kinase 2	Homo sapiens	23-37
35473503-12	2022	Curcumin inhibited the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway.	Curcumin	0-8	Janus kinase 2	Homo sapiens	39-43
35473503-14	2022	These results reveal that curcumin protects against RA by regulating the inc00052/miR-126-5p/PIAS2 axis through JAK2/STAT3 signaling pathway.	Curcumin	26-34	Janus kinase 2	Homo sapiens	112-116
35532218-4	2022	Results demonstrate that a 3 h pretreatment of curcumin, followed by the treatment of gliadin protein for 24 h time period protected both the HCT-116 and HT-29 cells via: (i) decreasing the ROS/RNS, restoring the mitochondrial transmembrane potential; (ii) re-establishing the cellular antioxidant defense system (superoxide dismutase, catalase, and GSH); (iii) enhancing the functions of APE1 viz.	Curcumin	47-55	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	389-393
35179079-0	2022	Curcumin suppresses TGF-beta2-induced proliferation, migration, and invasion in lens epithelial cells by targeting KCNQ1OT1/miR-377-3p/COL1A2 axis in posterior capsule opacification.	Curcumin	0-8	microRNA 377	Homo sapiens	124-131
35179079-15	2022	CONCLUSION: In conclusion, Curcumin suppressed TGF-beta2-induced malignant changes in lens epithelial cells by targeting KCNQ1OT1/miR-377-3p/COL1A2 axis.	Curcumin	27-35	microRNA 377	Homo sapiens	130-137
24036253-6	2013	After administration of curcumin, the parameters were ameliorated to a large extent; (ii) curcumin treatment dose-dependently augmented the ghrelin levels of stomach and plasma, which were earlier depleted in the diabetic control rats.	Curcumin	90-98	ghrelin and obestatin prepropeptide	Rattus norvegicus	140-147
24036253-7	2013	Conversely, the expression of ghrelin mRNA was decreased after curcumin treatment; and (iii) the gastric emptying in curcumin treated diabetic rats was notably accelerated compared with the diabetic control rats.	Curcumin	63-71	ghrelin and obestatin prepropeptide	Rattus norvegicus	30-37
35531069-13	2022	Trehalose and curcumin are novel agents acting on TFEB.	Curcumin	14-22	transcription factor EB	Homo sapiens	50-54
24036253-7	2013	Conversely, the expression of ghrelin mRNA was decreased after curcumin treatment; and (iii) the gastric emptying in curcumin treated diabetic rats was notably accelerated compared with the diabetic control rats.	Curcumin	117-125	ghrelin and obestatin prepropeptide	Rattus norvegicus	30-37
24228095-11	2013	The expression of Bax and Caspase-3 were dramatically increased after 5-FU treatment (p&lt;0.01) and Curcumin treatment significantly reduced Bax expression (p&lt;0.05) but had only a moderate effect on reducing caspase-3 expression (p&gt;0.05).	Curcumin	101-109	caspase 3	Rattus norvegicus	212-221
35566014-6	2022	The other ligands, namely chicoric acid, demothoxycurcumin, and curcumin express high binding energy than the other tested ligands docked to PLpro with -7.62, -6.81, and -6.70 kcal/mol, respectively.	Curcumin	64-72	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	141-146
24011306-6	2013	Curcumin potently inhibited LPS-induced expression of IL-6, TNF-alpha and COX-2 mRNA and prevented LPS-induced inhibition of SOCS-1 and -3 expression and the inhibition of the activation of p38 MAPKinase by modulation of its nuclear translocation.	Curcumin	0-8	cytochrome c oxidase II, mitochondrial	Mus musculus	74-79
35184332-0	2022	Synergistic effect of curcumin and resveratrol on the prevention of contrast-induced nephropathy by suppressing inflammation via regulating signaling pathways of microRNA-17/TXNIP/NRLP3 and microRNA-30c/FOXO3/NRLP3.	Curcumin	22-30	forkhead box O3	Rattus norvegicus	203-208
24011306-6	2013	Curcumin potently inhibited LPS-induced expression of IL-6, TNF-alpha and COX-2 mRNA and prevented LPS-induced inhibition of SOCS-1 and -3 expression and the inhibition of the activation of p38 MAPKinase by modulation of its nuclear translocation.	Curcumin	0-8	mitogen-activated protein kinase 14	Mus musculus	190-193
24011306-7	2013	In conclusion, curcumin potently inhibits expression of LPS-induced inflammatory cytokines in macrophages via mechanisms that involve modulation of expression and activity of SOCS-1 and SOCS-3 and of p38 MAPK.	Curcumin	15-23	mitogen-activated protein kinase 14	Mus musculus	200-208
35157901-2	2022	In pursuance of alternative medicines, in this study, covalent modification of chitosan (CS) polymer with curcumin (Cur) was accomplished.	Curcumin	106-114	citrate synthase	Homo sapiens	89-91
35157901-3	2022	Proton Nuclear Magnetic Resonance and Fourier Transform Infrared spectroscopy elucidated the covalent interaction between Cur and CS with characteristic peak of imine functional group (C=N).	Curcumin	122-125	citrate synthase	Homo sapiens	130-132
35072580-0	2022	Statement of Retraction: Curcumin deactivates M2 macrophages to alleviate lung fibrosis in IgG4-related disease through activating the toll-like receptor 9 pathway.	Curcumin	25-33	toll like receptor 9	Homo sapiens	135-155
23684744-0	2013	Molecular flexibility and the electrostatic moments of curcumin and its derivatives in the active site of p300: a theoretical charge density study.	Curcumin	55-63	E1A binding protein p300	Homo sapiens	106-110
35115932-9	2021	Results: Curcumin significantly ameliorated the inflammation process subsequent to myocardial infarction, reflected by decreased expression of CD68+ and CD3+ cells, accompanied by dramatically improved cardiac function compared with the placebo group.	Curcumin	9-17	Cd68 molecule	Rattus norvegicus	143-147
35409247-11	2022	CONCLUSIONS: The study first showed that Cur and DMC demonstrated antiangiogenic activity via the inhibition of endoglin/Smad1 signaling.	Curcumin	41-44	SMAD family member 1	Homo sapiens	121-126
35325302-5	2022	Since the genetic signature of microglia offers many potential targets for drug discovery, molecular docking followed by molecular dynamics (MD) simulations of cluster of differentiation 40 ligand (CD40L) and colony-stimulating factor 1 receptor (CSF1R) kinase domain protein with some known neuro-immunomodulators (Curcumin, Cannabidiol, Ginsenoside Rg1, Resveratrol, and Sulforaphane) has been evaluated.	Curcumin	316-324	colony stimulating factor 1 receptor	Homo sapiens	209-245
23684744-1	2013	A molecular docking analysis and quantum chemical calculation coupled with the charge density analysis have been carried out to understand the conformational change, charge density distribution and the electrostatic properties of HAT inhibitors curcumin and its derivatives (cinnamoyl compounds) in the active site of p300.	Curcumin	245-253	E1A binding protein p300	Homo sapiens	318-322
35289676-4	2022	Chlorogenic acid (CGA), curcumin (CUR), epigallocatechin gallate (EGCG), and resveratrol (RSV) can act as antioxidants that activate AMP-activated protein kinase (AMPK) to downregulate ROS, and as prooxidants to generate ROS, leading to the downregulation of NF-kappaB.	Curcumin	24-32	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	133-161
23946685-6	2013	Moreover, western blot analysis revealed that curcumin lowered radiation-induced increases of tumor necrosis factor-alpha (TNF-alpha), TNF receptor 1 (TNFR1), and cyclooxygenase-2 (COX-2).	Curcumin	46-54	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	163-179
35289676-4	2022	Chlorogenic acid (CGA), curcumin (CUR), epigallocatechin gallate (EGCG), and resveratrol (RSV) can act as antioxidants that activate AMP-activated protein kinase (AMPK) to downregulate ROS, and as prooxidants to generate ROS, leading to the downregulation of NF-kappaB.	Curcumin	24-32	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	163-167
35289676-4	2022	Chlorogenic acid (CGA), curcumin (CUR), epigallocatechin gallate (EGCG), and resveratrol (RSV) can act as antioxidants that activate AMP-activated protein kinase (AMPK) to downregulate ROS, and as prooxidants to generate ROS, leading to the downregulation of NF-kappaB.	Curcumin	34-37	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	133-161
35289676-4	2022	Chlorogenic acid (CGA), curcumin (CUR), epigallocatechin gallate (EGCG), and resveratrol (RSV) can act as antioxidants that activate AMP-activated protein kinase (AMPK) to downregulate ROS, and as prooxidants to generate ROS, leading to the downregulation of NF-kappaB.	Curcumin	34-37	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	163-167
23946685-6	2013	Moreover, western blot analysis revealed that curcumin lowered radiation-induced increases of tumor necrosis factor-alpha (TNF-alpha), TNF receptor 1 (TNFR1), and cyclooxygenase-2 (COX-2).	Curcumin	46-54	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	181-186
35256924-7	2022	Curcumin administration or si-LINC00691 transfection alone promoted ATP levels, inhibited glucose uptake and lactic acid levels, and inhibited lactate dehydrogenase A and hexokinase 2 protein expression in B-CPAP cells, which were further enhanced by combination treatment.	Curcumin	0-8	hexokinase 2	Homo sapiens	171-183
23946688-4	2013	We found that curcumin treatment resulted in an induction of apoptosis in MDA-MB-231 cells, together with downregulation of Notch1 and its downstream target, Hes1.	Curcumin	14-22	hes family bHLH transcription factor 1	Homo sapiens	158-162
35300350-11	2021	Curcumin can inhibit miR-21 expression and consequently activate apoptosis through caspase 3 and death receptor (DR) 4 and 5 activation.	Curcumin	0-8	TNF receptor superfamily member 10a	Homo sapiens	97-124
23666203-5	2013	In vitro, treatment of the human Ben-Men-1 meningioma cell line and of a series of 21 primary human meningioma cell cultures with curcumin (1-20 muM) strongly reduced the proliferation in all cases in a dose dependent manner.	Curcumin	130-138	GTF2I repeat domain containing 1	Homo sapiens	33-36
34928371-4	2022	KEY FINDINGS: Results demonstrated that curcumin nanoemulsion was superior to curcumin powder, particularly in enhancing the percentage progressive motility of spermatozoa, normalization of essential and non-essential amino acids in semen, normalization of serum leptin and testosterone levels, as well as normalization of oxidative and nitrosative parameters.	Curcumin	40-48	leptin	Rattus norvegicus	263-269
34980778-9	2022	Mechanistically, curcumin + HH suppressed protein expression of stromal cell-derived factor-1 (SDF-1), CXC chemokine receptor 4 (CXCR4), p-Akt, and c-fos while enhancing protein expression of nerve growth factor (NGF) in the dorsal root ganglia (DRG) of model rats.	Curcumin	17-25	C-X-C motif chemokine ligand 12	Rattus norvegicus	64-93
23666203-7	2013	High dosages (20, 50 muM) of curcumin induced a significant increase of apoptosis in Ben-Men-1 and primary meningioma cell cultures as demonstrated by morphological changes of cell nuclei, DNA fragmentation, translocation of cell membrane associated phosphatidyl serine and the induction of apoptotic-acting cleaved caspase-3.	Curcumin	29-37	GTF2I repeat domain containing 1	Homo sapiens	85-88
34980778-9	2022	Mechanistically, curcumin + HH suppressed protein expression of stromal cell-derived factor-1 (SDF-1), CXC chemokine receptor 4 (CXCR4), p-Akt, and c-fos while enhancing protein expression of nerve growth factor (NGF) in the dorsal root ganglia (DRG) of model rats.	Curcumin	17-25	C-X-C motif chemokine ligand 12	Rattus norvegicus	95-100
34980778-10	2022	Curcumin + HH inhibited the expression and production of interleukin 1beta (IL-1beta), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and p65 nuclear factor kappa B (NF-kappaB) in the DRG.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	87-103
23825622-4	2013	Here, we report that topical use of a curcumin gel formulation strongly inhibited imiquimod (IMQ)-induced psoriasis-like inflammation, the development of which was based on the IL-23/IL-17A axis.	Curcumin	38-46	interleukin 23, alpha subunit p19	Mus musculus	177-182
34980778-10	2022	Curcumin + HH inhibited the expression and production of interleukin 1beta (IL-1beta), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and p65 nuclear factor kappa B (NF-kappaB) in the DRG.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	105-110
34980778-11	2022	Coadministration of curcumin and HH alleviates incision + formaldehyde-induced pain in rats, possibly by suppressing the SDF-1/CXCR4 pathway and the production of proinflammatory mediators.	Curcumin	20-28	C-X-C motif chemokine ligand 12	Rattus norvegicus	121-126
23739680-6	2013	Two main cell cycle related proteins cyclin D1 and cyclin B1 were significantly inhibited at the present of EGCG and curcumin.	Curcumin	117-125	cyclin B1	Mus musculus	51-60
35264470-8	2022	Curcumin was found to decrease the number of T-helper 17 cells, downregulate T-helper-17 cell-related factors, reduce levels of T-helper-17 cell-related cytokines, yet increase the gene expression of Treg transcription factor forkhead box P3 (FOXP3), and decrease T-Box transcription factor 21 (TBX21).	Curcumin	0-8	forkhead box P3	Homo sapiens	226-241
35264470-8	2022	Curcumin was found to decrease the number of T-helper 17 cells, downregulate T-helper-17 cell-related factors, reduce levels of T-helper-17 cell-related cytokines, yet increase the gene expression of Treg transcription factor forkhead box P3 (FOXP3), and decrease T-Box transcription factor 21 (TBX21).	Curcumin	0-8	forkhead box P3	Homo sapiens	243-248
35549587-9	2022	ICAM1 and CD40, which highly expressed in myocarditis patients, were identified as targets of curcumin and negatively regulated by curcumin.	Curcumin	94-102	CD40 molecule	Homo sapiens	10-14
35549587-9	2022	ICAM1 and CD40, which highly expressed in myocarditis patients, were identified as targets of curcumin and negatively regulated by curcumin.	Curcumin	131-139	CD40 molecule	Homo sapiens	10-14
23548270-10	2013	We found that curcumin administration increased miR-145 promoter activity, thereby decreasing SOX9/ADAM17 expression and eliminating TICs in HNC cell populations.	Curcumin	14-22	SRY-box transcription factor 9	Homo sapiens	94-98
23548270-13	2013	Collectively, our results show how miR-145 targets the SOX9/ADAM17 axis to regulate TIC properties in HNC, and how altering this pathway may partly explain the anticancer effects of curcumin.	Curcumin	182-190	SRY-box transcription factor 9	Homo sapiens	55-59
23735000-0	2013	Curcumin downregulates aquaporin-1 expression in cultured rat choroid plexus cells.	Curcumin	0-8	aquaporin 1	Rattus norvegicus	23-34
23735000-5	2013	We therefore speculated that curcumin might be a useful tool to inhibit and/or decrease AQP1, and thus might be useful in the regulation of CSF production in pathophysiological conditions, including traumatic brain injury, hydrocephalus, stroke, systemic hyponatremia, acute cerebral edema, and hypertension.	Curcumin	29-37	aquaporin 1	Rattus norvegicus	88-92
23735000-8	2013	Our results showed that curcumin treatment decreases AQP1 expression in rat choroid epithelium cells in a dose-dependent manner.	Curcumin	24-32	aquaporin 1	Rattus norvegicus	53-57
23730211-4	2013	We have shown that curcumin treatment upregulates p16(INK4A) and other tumor suppressor proteins while inactivates the JAK2/STAT3 pathway.	Curcumin	19-27	Janus kinase 2	Homo sapiens	119-123
23730211-6	2013	Furthermore, curcumin suppressed the expression/secretion of stromal cell-derived factor-1 (SDF-1), interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2), MMP-9, and transforming growth factor-beta, which impeded their paracrine procarcinogenic potential.	Curcumin	13-21	C-X-C motif chemokine ligand 12	Homo sapiens	61-90
23730211-6	2013	Furthermore, curcumin suppressed the expression/secretion of stromal cell-derived factor-1 (SDF-1), interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2), MMP-9, and transforming growth factor-beta, which impeded their paracrine procarcinogenic potential.	Curcumin	13-21	C-X-C motif chemokine ligand 12	Homo sapiens	92-97
23730211-6	2013	Furthermore, curcumin suppressed the expression/secretion of stromal cell-derived factor-1 (SDF-1), interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2), MMP-9, and transforming growth factor-beta, which impeded their paracrine procarcinogenic potential.	Curcumin	13-21	matrix metallopeptidase 2	Homo sapiens	122-148
23730211-6	2013	Furthermore, curcumin suppressed the expression/secretion of stromal cell-derived factor-1 (SDF-1), interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2), MMP-9, and transforming growth factor-beta, which impeded their paracrine procarcinogenic potential.	Curcumin	13-21	matrix metallopeptidase 2	Homo sapiens	150-155
23730211-8	2013	Therefore, using different markers of senescence [senescence-associated beta-galactosidase (SA-beta-gal) activity, Ki-67 and Lamin B1 levels, and bromodeoxyuridine incorporation], we have shown that curcumin markedly suppresses Lamin B1 and triggers DNA damage-independent senescence in proliferating but not quiescent breast stromal fibroblasts.	Curcumin	199-207	galactosidase beta 1	Homo sapiens	72-90
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	15-23	activating transcription factor 6	Mus musculus	234-267
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	15-23	activating transcription factor 6	Mus musculus	269-274
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	15-23	caspase 12	Mus musculus	317-327
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	100-108	activating transcription factor 6	Mus musculus	234-267
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	100-108	activating transcription factor 6	Mus musculus	269-274
23245727-8	2013	Renal TNF-alpha and MCP-1 concentrations and ICAM-1 mRNA expression in kidney in the cisplatin + curcumin group also significantly decreased compared with those in the cisplatin group.	Curcumin	97-105	intercellular adhesion molecule 1	Mus musculus	45-51
22898567-2	2013	We assumed that curcumin, a polyphenol, would attenuate the tissue dyslipidemic condition through activation of 5" adenosine monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and suppression of sterol regulatory element-binding protein (SREBP)-1c in the kidney and would prevent renal progression in experimental type 1 diabetic rats.	Curcumin	16-24	sterol regulatory element binding transcription factor 1	Rattus norvegicus	212-264
22898567-6	2013	Furthermore, treatment of diabetic rats with curcumin increased the phosphorylation of AMPK and prevented the increased renal expression of SREBP-1c and, as a result, decreased the expression of acetyl CoA carboxylase and fatty acid synthase as well as adipose differentiation-related protein, a marker of cytoplasmic droplets.	Curcumin	45-53	sterol regulatory element binding transcription factor 1	Rattus norvegicus	140-148
22898567-6	2013	Furthermore, treatment of diabetic rats with curcumin increased the phosphorylation of AMPK and prevented the increased renal expression of SREBP-1c and, as a result, decreased the expression of acetyl CoA carboxylase and fatty acid synthase as well as adipose differentiation-related protein, a marker of cytoplasmic droplets.	Curcumin	45-53	fatty acid synthase	Rattus norvegicus	222-241
23184090-0	2013	Curcumin protects against collagen-induced arthritis via suppression of BAFF production.	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	72-76
23184090-1	2013	PURPOSE: The aim of the present study was to evaluate whether the anti-Rheumatoid arthritis (RA) effect of curcumin is associated with the regulation of B cell-activating factor belonging to the TNF family (BAFF) production.	Curcumin	107-115	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	153-177
23184090-1	2013	PURPOSE: The aim of the present study was to evaluate whether the anti-Rheumatoid arthritis (RA) effect of curcumin is associated with the regulation of B cell-activating factor belonging to the TNF family (BAFF) production.	Curcumin	107-115	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	207-211
23184090-6	2013	Furthermore, the effect of curcumin on IFNgamma-induced BAFF expression and transcriptional activation in B lymphocytes was determined by qPCR, Western Blot, and luciferase assay.	Curcumin	27-35	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	56-60
23184090-8	2013	RESULTS: Curcumin dramatically attenuated the progression and severity of CIA in DBA/1 J mice, accompanied with decrease of BAFF production in serum and spleen cells as well as decrease of serum IFNgamma and IL-6.	Curcumin	9-17	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	124-128
23184090-9	2013	Treatment of B lymphocytes with curcumin suppressed IFNgamma-induced BAFF expression, STAT1 phosphorylation and nuclear translocation, suggesting that curcumin may repress IFNgamma-induced BAFF expression via negatively interfering with STAT1 signaling.	Curcumin	32-40	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	69-73
23184090-9	2013	Treatment of B lymphocytes with curcumin suppressed IFNgamma-induced BAFF expression, STAT1 phosphorylation and nuclear translocation, suggesting that curcumin may repress IFNgamma-induced BAFF expression via negatively interfering with STAT1 signaling.	Curcumin	32-40	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	189-193
23184090-9	2013	Treatment of B lymphocytes with curcumin suppressed IFNgamma-induced BAFF expression, STAT1 phosphorylation and nuclear translocation, suggesting that curcumin may repress IFNgamma-induced BAFF expression via negatively interfering with STAT1 signaling.	Curcumin	151-159	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	189-193
23184090-10	2013	CONCLUSION: The results of the present study suggest that suppression of BAFF production may be a novel mechanism by which curcumin improves RA.	Curcumin	123-131	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	73-77
23566056-8	2013	The results of this study suggest that oral curcumin treatment decreases colon injury and is associated with decreased inflammatory reactions, lipid peroxidation, apoptotic cell death, and modulating p38- and JNK-MAPK pathways.	Curcumin	44-52	mitogen activated protein kinase 14	Rattus norvegicus	200-203
23352975-5	2013	KEY FINDINGS: Curcumin treatment resulted in a fast and significant increase of Fas and Fas ligand (FasL) along with activation of caspase-3 and cleavage of PARP in Huh7 cells.	Curcumin	14-22	collagen type XI alpha 2 chain	Homo sapiens	157-161
23264626-10	2013	Instead curcumin differentially impacted HSP90 client kinases, reducing Fyn without reducing Akt.	Curcumin	8-16	heat shock protein 86, pseudogene 1	Mus musculus	41-46
23476444-1	2013	The title compound, C22H21Cl2NO, is a derivative of mono-carbonyl analogues of curcumin (MACs).	Curcumin	79-87	myristoylated alanine rich protein kinase C substrate	Homo sapiens	89-93
23302632-6	2013	In order to develop novel heart failure therapy targeting the pathway in cardiomyocytes, we have studied the potential of curcumin, a p300 histone acetyltransferase inhibitor, as an agent for novel heart failure therapy.	Curcumin	122-130	E1A binding protein p300	Homo sapiens	134-138
35012734-0	2022	Expression of Concern "Curcumin inhibits proliferation and soluble collagen synthesis of NIH/3T3 cell line by modulation of miR-29a and via ERK1/2 and beta-catenin pathways" (Mol.	Curcumin	23-31	microRNA 29a	Mus musculus	124-131
35012734-0	2022	Expression of Concern "Curcumin inhibits proliferation and soluble collagen synthesis of NIH/3T3 cell line by modulation of miR-29a and via ERK1/2 and beta-catenin pathways" (Mol.	Curcumin	23-31	mitogen-activated protein kinase 3	Mus musculus	140-146
23302632-7	2013	In this review, we describe a recent study on the cardiac transcriptional signal pathway, especially p300/GATA4 pathway, and a novel heart failure therapy using curcumin.	Curcumin	161-169	E1A binding protein p300	Homo sapiens	101-105
23116317-0	2013	Promising curcumin-based drug design: mono-carbonyl analogues of curcumin (MACs).	Curcumin	10-18	myristoylated alanine rich protein kinase C substrate	Homo sapiens	75-79
23116317-0	2013	Promising curcumin-based drug design: mono-carbonyl analogues of curcumin (MACs).	Curcumin	65-73	myristoylated alanine rich protein kinase C substrate	Homo sapiens	75-79
23116317-7	2013	Particularly, the latter called mono-carbonyl analogs of curcumin (MACs) has been reported to has an enhanced stability in vitro and an improved pharmacokinetic profile in vivo.	Curcumin	57-65	myristoylated alanine rich protein kinase C substrate	Homo sapiens	67-71
23116317-8	2013	Thus, MACs have attracted a high attention for development of new curcumin-based agents with both enhanced bioactivities and pharmacokinetic profiles.	Curcumin	66-74	myristoylated alanine rich protein kinase C substrate	Homo sapiens	6-10
23235109-7	2013	Treatment with the histone acetyltransferase (HAT) inhibitor curcumin reduces H3K9Ac levels in the NKG2D gene, downregulates NKG2D transcription and leads to a marked reduction in the lytic capacity of NKG2D-mediated NKL cells.	Curcumin	61-69	killer cell lectin like receptor K1	Homo sapiens	99-104
23235109-7	2013	Treatment with the histone acetyltransferase (HAT) inhibitor curcumin reduces H3K9Ac levels in the NKG2D gene, downregulates NKG2D transcription and leads to a marked reduction in the lytic capacity of NKG2D-mediated NKL cells.	Curcumin	61-69	killer cell lectin like receptor K1	Homo sapiens	125-130
23970932-0	2013	Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer.	Curcumin	0-8	protein tyrosine kinase 2	Homo sapiens	41-44
23970932-7	2013	Curcumin inhibits focal adhesion kinase (FAK) phosphorylation and enhances the expressions of several extracellular matrix components which play a critical role in invasion and metastasis.	Curcumin	0-8	protein tyrosine kinase 2	Homo sapiens	18-39
23970932-7	2013	Curcumin inhibits focal adhesion kinase (FAK) phosphorylation and enhances the expressions of several extracellular matrix components which play a critical role in invasion and metastasis.	Curcumin	0-8	protein tyrosine kinase 2	Homo sapiens	41-44
23970932-10	2013	These results suggest that curcumin executes its antimetastasis function through downregulation of Sp-1, FAK, and CD24 and by promoting E-cadherin expression in CRC cells.	Curcumin	27-35	protein tyrosine kinase 2	Homo sapiens	105-108
24048094-0	2013	Curcumin induces autophagy via activating the AMPK signaling pathway in lung adenocarcinoma cells.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	46-50
24048094-6	2013	Curcumin markedly increased the phosphorylation of AMP-activated protein kinase (AMPK) and acetylCoA carboxylase in A549 cells.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	81-85
24048094-7	2013	At last, pharmacological blockade of the AMPK signaling pathway by compound C and genetic disruption of the AMPK signaling pathway with siRNA-mediated AMPKalpha1 knockdown impaired the autophagy-inducing effect of curcumin.	Curcumin	214-222	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	41-45
24048094-7	2013	At last, pharmacological blockade of the AMPK signaling pathway by compound C and genetic disruption of the AMPK signaling pathway with siRNA-mediated AMPKalpha1 knockdown impaired the autophagy-inducing effect of curcumin.	Curcumin	214-222	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	108-112
24048094-7	2013	At last, pharmacological blockade of the AMPK signaling pathway by compound C and genetic disruption of the AMPK signaling pathway with siRNA-mediated AMPKalpha1 knockdown impaired the autophagy-inducing effect of curcumin.	Curcumin	214-222	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	151-161
24048094-8	2013	Collectively, our data suggests that curcumin induces autophagy via activating the AMPK signaling pathway and the autophagy is important for the inhibiting effect of curcumin in lung adenocarcinoma cells.	Curcumin	37-45	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	83-87
23710286-5	2013	High concentration of curcumin (20 muM) also increased protein expression of long isoforms of NRF1.	Curcumin	22-30	nuclear respiratory factor 1	Homo sapiens	94-98
23710286-6	2013	Treatment with low concentrations of curcumin (2.5 or 5 muM) effectively increased the viability and survival of HaCaT cells against iAs(3+)-induced cytotoxicity as assessed by the MTT assay and flow cytometry and also attenuated iAs(3+)-induced expression of cleaved caspase-3 and cleaved PARP protein.	Curcumin	37-45	collagen type XI alpha 2 chain	Homo sapiens	290-294
23555722-12	2013	Whereas low concentrations of curcumin stimulated the expression of bFGF and HGF, high concentrations caused downregulation of both factors.	Curcumin	30-38	hepatocyte growth factor	Homo sapiens	77-80
23544048-6	2013	Curcumin reduced TGF-beta receptor type I (TbetaR-I) and TGF-beta receptor type II (TbetaR II), but had no effect on phosphorylation of Smad2 and Smad3.	Curcumin	0-8	transforming growth factor beta receptor 2	Homo sapiens	57-82
23544048-6	2013	Curcumin reduced TGF-beta receptor type I (TbetaR-I) and TGF-beta receptor type II (TbetaR II), but had no effect on phosphorylation of Smad2 and Smad3.	Curcumin	0-8	transforming growth factor beta receptor 2	Homo sapiens	84-93
23451189-9	2013	Curcumin potentiated 5-FU-induced expression or cleavage of pro-apoptotic proteins (caspase-8, -9, -3, PARP and Bax), and down-regulated anti-apoptotic (Bcl-xL) and proliferative (cyclin D1) proteins.	Curcumin	0-8	caspase 8	Homo sapiens	84-101
23451189-9	2013	Curcumin potentiated 5-FU-induced expression or cleavage of pro-apoptotic proteins (caspase-8, -9, -3, PARP and Bax), and down-regulated anti-apoptotic (Bcl-xL) and proliferative (cyclin D1) proteins.	Curcumin	0-8	cyclin D1	Homo sapiens	180-189
23600205-6	2013	RESULTS: When SiHa cells were pretreated with aspirin, sulindac, curcumin or PDTC, Western blot showed that the expression of P65 was inhibited upon cisplatin stimulus (P &lt; 0.05).	Curcumin	65-73	RELA proto-oncogene, NF-kB subunit	Homo sapiens	126-129
22982865-0	2012	Short curcumin treatment modulates oxidative stress, arginase activity, aberrant crypt foci, and TGF-beta1 and HES-1 transcripts in 1,2-dimethylhydrazine-colon carcinogenesis in mice.	Curcumin	6-14	transforming growth factor, beta 1	Mus musculus	97-106
22982865-0	2012	Short curcumin treatment modulates oxidative stress, arginase activity, aberrant crypt foci, and TGF-beta1 and HES-1 transcripts in 1,2-dimethylhydrazine-colon carcinogenesis in mice.	Curcumin	6-14	hes family bHLH transcription factor 1	Mus musculus	111-116
22982865-8	2012	Interestingly, curcumin induced a parallel increase in TGF-beta1 and HES-1 transcripts (42% and 26%, respectively).	Curcumin	15-23	transforming growth factor, beta 1	Mus musculus	55-64
22982865-8	2012	Interestingly, curcumin induced a parallel increase in TGF-beta1 and HES-1 transcripts (42% and 26%, respectively).	Curcumin	15-23	hes family bHLH transcription factor 1	Mus musculus	69-74
22982865-10	2012	The up regulation of TGF-beta1 and HES-1 expression by curcumin suggests for the first time, a potential interplay between these signalling pathways in the chemoprotective mechanism of curcumin.	Curcumin	55-63	transforming growth factor, beta 1	Mus musculus	21-30
22982865-10	2012	The up regulation of TGF-beta1 and HES-1 expression by curcumin suggests for the first time, a potential interplay between these signalling pathways in the chemoprotective mechanism of curcumin.	Curcumin	55-63	hes family bHLH transcription factor 1	Mus musculus	35-40
22982865-10	2012	The up regulation of TGF-beta1 and HES-1 expression by curcumin suggests for the first time, a potential interplay between these signalling pathways in the chemoprotective mechanism of curcumin.	Curcumin	185-193	transforming growth factor, beta 1	Mus musculus	21-30
22982865-10	2012	The up regulation of TGF-beta1 and HES-1 expression by curcumin suggests for the first time, a potential interplay between these signalling pathways in the chemoprotective mechanism of curcumin.	Curcumin	185-193	hes family bHLH transcription factor 1	Mus musculus	35-40
23242714-11	2012	This was further confirmed by immunoblotting of the protein Cyclin D1, whose expression were found to be decreased in both curcumin and BDMC-A treatment.	Curcumin	123-131	cyclin D1	Homo sapiens	60-69
22438101-3	2012	Further, perifosine and curcumin synergistically increase intracellular level of reactive oxygen species and ceramide, and downregulate the expression of cyclin D1 and Bcl-2 in colorectal cancer cells.	Curcumin	24-32	cyclin D1	Homo sapiens	154-163
23194063-6	2012	Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), survivin, bcl-2, cyclin D1 and NFkappaB (p65 and p50).	Curcumin	0-8	cyclin D1	Homo sapiens	339-348
23194063-6	2012	Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), survivin, bcl-2, cyclin D1 and NFkappaB (p65 and p50).	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	363-366
23194063-8	2012	The mechanism of curcumin-/RL197-induced repression of Sp transcription factors was ROS-dependent and due to induction of the Sp repressors ZBTB10 and ZBTB4 and downregulation of microRNAs (miR)-27a, miR-20a and miR-17-5p that regulate these repressors.	Curcumin	17-25	microRNA 17	Homo sapiens	212-221
22890222-0	2012	Curcumin mediated epigenetic modulation inhibits TREM-1 expression in response to lipopolysaccharide.	Curcumin	0-8	triggering receptor expressed on myeloid cells 1	Mus musculus	49-55
22890222-3	2012	In this study, we show that curcumin or diferuloylmethane, a yellow pigment present in turmeric, a major ingredient of curry spice inhibited the expression of TREM-1 in vitro in primary bone marrow derived macrophages and in vivo in lungs of mice with sepsis.	Curcumin	28-36	triggering receptor expressed on myeloid cells 1	Mus musculus	159-165
22890222-3	2012	In this study, we show that curcumin or diferuloylmethane, a yellow pigment present in turmeric, a major ingredient of curry spice inhibited the expression of TREM-1 in vitro in primary bone marrow derived macrophages and in vivo in lungs of mice with sepsis.	Curcumin	40-57	triggering receptor expressed on myeloid cells 1	Mus musculus	159-165
22890222-4	2012	Chromatin immunoprecipitation assay confirmed that curcumin inhibits the binding of p65 to TREM-1 promoter in response to LPS.	Curcumin	51-59	triggering receptor expressed on myeloid cells 1	Mus musculus	91-97
22890222-5	2012	Further we show that curcumin inhibited p300 activity in the TREM-1 promoter region leading to hypoacetylation of histone 3 and 4 in the lysine residues.	Curcumin	21-29	triggering receptor expressed on myeloid cells 1	Mus musculus	61-67
22890222-6	2012	Inhibition of TREM-1 by curcumin is oxidant independent.	Curcumin	24-32	triggering receptor expressed on myeloid cells 1	Mus musculus	14-20
22890222-7	2012	These studies are the first report to define a detailed molecular mechanism by which curcumin exerts anti-inflammatory effects through regulation of TREM-1 gene activity and provide additional mechanistic insights into the anti-inflammatory effect of curcumin.	Curcumin	85-93	triggering receptor expressed on myeloid cells 1	Mus musculus	149-155
22992310-4	2012	Moreover, we also assessed the expression of miR-34 in colon cancer cell lines treated with our newly developed synthetic analogue of curcumin referred as difluorinated curcumin (CDF) compared to well known inhibitor of methyl transferase.	Curcumin	134-142	microRNA 34a	Homo sapiens	45-51
22830632-7	2012	An inducing effect of curcumin and quercetin on GST or UGT was seen in Caco-2, LT97, and HuTu 80 cells.	Curcumin	22-30	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	55-58
22830632-9	2012	In LT97 cells, GST activity and expression was reduced, but UGT1 expression was induced by curcumin and quercetin; whereas EPA only decreased GST or UGT levels.	Curcumin	91-99	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	60-64
22830632-9	2012	In LT97 cells, GST activity and expression was reduced, but UGT1 expression was induced by curcumin and quercetin; whereas EPA only decreased GST or UGT levels.	Curcumin	91-99	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	60-63
22548787-9	2012	Administration of pure curcumin or its water-soluble conjugate led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in eNOS, nNOS, HO-1, and Nrf2 genes, and a significant decrease in NF-Kbeta, p38, and iNOS genes.	Curcumin	23-31	mitogen activated protein kinase 14	Rattus norvegicus	263-266
22591841-7	2012	Specific molecular targets of CURCUMIN, not observed for NSAID, were the IkB up regulation in the "TNRF1 signaling pathway" and IL18 down regulation in the "role of cytokines in mediating communication between immune cells".	Curcumin	30-38	interleukin 18	Canis lupus familiaris	128-132
22591841-8	2012	The activity of CURCUMIN was also evidenced from the inhibition of macrophages proliferation (HBEGF), related to a strong down regulation of TNFalpha and to activation of fibrinolysis (SERPINE1).	Curcumin	16-24	serpin family E member 1	Canis lupus familiaris	185-193
22475723-8	2012	Further bioinformatic analysis shows that proteins modulated by curcumin are implicated in protein folding (such as heat-shock protein PPP2R1A; RNA splicing proteins RBM17, DDX39; cell death proteins HMGB1 and NPM1; proteins involved in androgen receptor signaling, NPM1 and FKBP4/FKBP52), and that this compound could have an impact on miR-141, miR-152, and miR-183 expression.	Curcumin	64-72	protein phosphatase 2 scaffold subunit Aalpha	Homo sapiens	135-142
22475723-8	2012	Further bioinformatic analysis shows that proteins modulated by curcumin are implicated in protein folding (such as heat-shock protein PPP2R1A; RNA splicing proteins RBM17, DDX39; cell death proteins HMGB1 and NPM1; proteins involved in androgen receptor signaling, NPM1 and FKBP4/FKBP52), and that this compound could have an impact on miR-141, miR-152, and miR-183 expression.	Curcumin	64-72	high mobility group box 1	Homo sapiens	200-205
22475723-8	2012	Further bioinformatic analysis shows that proteins modulated by curcumin are implicated in protein folding (such as heat-shock protein PPP2R1A; RNA splicing proteins RBM17, DDX39; cell death proteins HMGB1 and NPM1; proteins involved in androgen receptor signaling, NPM1 and FKBP4/FKBP52), and that this compound could have an impact on miR-141, miR-152, and miR-183 expression.	Curcumin	64-72	nucleophosmin 1	Homo sapiens	210-214
22475723-8	2012	Further bioinformatic analysis shows that proteins modulated by curcumin are implicated in protein folding (such as heat-shock protein PPP2R1A; RNA splicing proteins RBM17, DDX39; cell death proteins HMGB1 and NPM1; proteins involved in androgen receptor signaling, NPM1 and FKBP4/FKBP52), and that this compound could have an impact on miR-141, miR-152, and miR-183 expression.	Curcumin	64-72	nucleophosmin 1	Homo sapiens	266-270
22664111-6	2012	The incidence of CD13/APN in CLL suggests that the inhibition of APN/CD13 by curcumin may be an effective new molecular target for a more efficient therapy for these patients and warrants further investigations.	Curcumin	77-85	alanyl aminopeptidase, membrane	Homo sapiens	17-21
22664111-6	2012	The incidence of CD13/APN in CLL suggests that the inhibition of APN/CD13 by curcumin may be an effective new molecular target for a more efficient therapy for these patients and warrants further investigations.	Curcumin	77-85	alanyl aminopeptidase, membrane	Homo sapiens	22-25
22664111-6	2012	The incidence of CD13/APN in CLL suggests that the inhibition of APN/CD13 by curcumin may be an effective new molecular target for a more efficient therapy for these patients and warrants further investigations.	Curcumin	77-85	alanyl aminopeptidase, membrane	Homo sapiens	65-68
22664111-6	2012	The incidence of CD13/APN in CLL suggests that the inhibition of APN/CD13 by curcumin may be an effective new molecular target for a more efficient therapy for these patients and warrants further investigations.	Curcumin	77-85	alanyl aminopeptidase, membrane	Homo sapiens	69-73
22436581-12	2012	Nonetheless, curcumin may serve as a potential therapeutic compound for PMD caused by PLP1 point mutations.	Curcumin	13-21	proteolipid protein (myelin) 1	Mus musculus	86-90
22588934-0	2012	[Effects of curcumin on syndecan-4 protein and p44/42 mitogen-activated protein kinase expression in tumor necrosis factor-alpha-induced rat vascular smooth muscle cells in vitro].	Curcumin	12-20	syndecan 4	Rattus norvegicus	24-34
22588934-1	2012	OBJECTIVE: To investigate the effects of curcumin on the expression of syndecan-4 protein and p44/42 mitogen- activated protein kinase(MAPK) phosphorylation in rat vascular smooth muscle cells (VSMCs) induced by tumor necrosis factor-alpha (TNF-alpha) in vitro.	Curcumin	41-49	syndecan 4	Rattus norvegicus	71-81
22588934-6	2012	TNF-alpha treatment also significantly increased the expression of syndecan-4 protein and phosphorylated p44/42 MAPK (P&lt;0.01), which was markedly lowered by treatment with curcumin (P/0.01).	Curcumin	175-183	syndecan 4	Rattus norvegicus	67-77
22588934-6	2012	TNF-alpha treatment also significantly increased the expression of syndecan-4 protein and phosphorylated p44/42 MAPK (P&lt;0.01), which was markedly lowered by treatment with curcumin (P/0.01).	Curcumin	175-183	mitogen activated protein kinase 3	Rattus norvegicus	105-108
22588934-8	2012	CONCLUSION: Curcumin can suppress the proliferation of rat VSMCs and lower the expression of syndecan-4 protein and phosphorylated p44/42 MAPK in TNF-alpha-induced VSMCs.	Curcumin	12-20	syndecan 4	Rattus norvegicus	93-103
22588934-8	2012	CONCLUSION: Curcumin can suppress the proliferation of rat VSMCs and lower the expression of syndecan-4 protein and phosphorylated p44/42 MAPK in TNF-alpha-induced VSMCs.	Curcumin	12-20	mitogen activated protein kinase 3	Rattus norvegicus	131-134
22475209-5	2012	RESULTS: KI mice fed a curcumin-containing diet since conception showed decreased huntingtin aggregates and increased striatal DARPP-32 and D1 receptor mRNAs, as well as an amelioration of rearing deficits.	Curcumin	23-31	dopamine receptor D1	Mus musculus	140-151
22484638-5	2012	We also analysed NF-kappaB p65 activation in curcumin-pre-treated OE33 cells exposed to deoxycholic acid (DCA) using ELISA.	Curcumin	45-53	RELA proto-oncogene, NF-kB subunit	Homo sapiens	27-30
22159410-1	2012	The aim of the present study was to investigate the apoptosis of human ovarian             cancer cell lines, A2780 and CP70, induced by a novel curcumin analogue, B19.	Curcumin	145-153	eva-1 homolog C	Homo sapiens	164-167
22159410-5	2012	A growth inhibitory effect was observed after             treatment with B19 in a dose-dependent manner and with more potential than curcumin.	Curcumin	133-141	eva-1 homolog C	Homo sapiens	73-76
21928347-5	2012	In contrast, induction of HO-1 with hemin or curcumin in bone marrow-derived macrophages or RAW-D murine osteoclast precursor cells inhibited osteoclastogenesis and suppressed HMGB1 release.	Curcumin	45-53	high mobility group box 1	Mus musculus	176-181
22029407-3	2012	Natural curcumins were shown to restore Abeta phagocytosis by AD PBMCs and to up-regulate the expression of key genes including MGAT3 and those encoding Toll-like receptors (TLRs).	Curcumin	8-17	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	128-133
22212430-11	2012	The AP-1 inhibitor curcumin (1-10 mumol/L) concentration-dependently attenuated thrombin-induced CTGF expression.	Curcumin	19-27	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	4-8
22994744-0	2012	Curcumin effect on MMPs and TIMPs genes in a breast cancer cell line.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	19-23
22994744-6	2012	At high concentrations of curcumin, TIMP-1, -2, -3 and -4 genes were up-regulated after 48 hours of treatment, their over-expression being accompanied by down-regulation of MMP-2 and MMP-9 gene expression levels in a concentration- and time-dependent manner.	Curcumin	26-34	matrix metallopeptidase 2	Homo sapiens	173-178
22994744-7	2012	These results suggest that curcumin plays a role in regulating cell metastasis by inhibiting MMP-2 and MMP-9 and up-regulating TIMP1 and TIMP4 gene expression in breast cancer cells.	Curcumin	27-35	matrix metallopeptidase 2	Homo sapiens	93-98
22994744-7	2012	These results suggest that curcumin plays a role in regulating cell metastasis by inhibiting MMP-2 and MMP-9 and up-regulating TIMP1 and TIMP4 gene expression in breast cancer cells.	Curcumin	27-35	TIMP metallopeptidase inhibitor 4	Homo sapiens	137-142
22832115-7	2012	Activating protein (AP-1) and nuclear factor kappa B (NF-kB) transcription factor inhibitors, curcumin and pyrrolidine dithiocarbamate (PDTC) partially inhibited ADAMTS-4 induction and activity.	Curcumin	94-102	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	162-170
34055082-5	2021	It was found that curcumin pretreatment significantly improved neurological scores, decreased infarct size, and protected synaptic remodeling of hippocampal neurons and upregulated the protein expression level of tight junction proteins, ZO-1, occludin and claudin-5 in ischemic rat brains.	Curcumin	18-26	tight junction protein 1	Rattus norvegicus	238-242
33548025-2	2021	The present study investigates the efficacy of curcumin nanoparticles against the cardiotoxic effects of cisplatin by assessment of oxidative stress parameters, Na+,K+-ATPase, acetylcholinesterase (AchE) and tumor necrosis factor-alpha (TNF-alpha) in cardiac tissue in addition to serum lactate dehydrogenase (LDH).	Curcumin	47-55	acetylcholinesterase	Rattus norvegicus	198-202
33539684-4	2021	In addition, curcumin decreased ALDH activity and the expression of stemness markers (CD133, EpCAM, Oct4).	Curcumin	13-21	POU class 5 homeobox 1	Homo sapiens	100-104
22005927-8	2012	Western blot revealed that curcumin reduced ox-LDL- induced p38 MAPK phosphorylation and nuclear NF-kappaB p65 protein at the indicated concentration.	Curcumin	27-35	mitogen activated protein kinase 14	Rattus norvegicus	60-63
22363450-11	2012	Finally, curcumin treatment down-regulate the expressions of Notch-1 specific microRNAs miR-21 and miR-34a, and upregulated tumor suppressor let-7a miRNA.	Curcumin	9-17	microRNA 34a	Homo sapiens	99-106
22139626-1	2011	The aim of the present study was to investigate the effect of curcumin (Cur) on the activity of ectonucleoside triphosphate diphosphohydrolase (CD39), 5"-nucleotidase (CD73) and adenosine deaminase in platelets of cigarette smoke-exposed rats.	Curcumin	62-70	5' nucleotidase, ecto	Rattus norvegicus	151-166
33076727-11	2021	CONCLUSIONS: Curcumin partially improved the lipid profile dysfunction by modulating NF-kB, MDA, SOD, and GPx in splenectomized rats while less likely improving any vascular and alveolar regeneration.	Curcumin	13-21	nuclear factor kappa B subunit 1	Rattus norvegicus	85-90
33713277-9	2021	In addition, we also found that curcumin inhibited the extracellular matrix (ECM)-receptor interaction pathway via the downregulation of the following genes: GP1BB, COL9A3, COMP, AGRN, ITGB4, LAMA5, COL2A1, ITGB6, ITGA1, and TNC.	Curcumin	32-40	integrin subunit beta 6	Homo sapiens	207-212
33713277-9	2021	In addition, we also found that curcumin inhibited the extracellular matrix (ECM)-receptor interaction pathway via the downregulation of the following genes: GP1BB, COL9A3, COMP, AGRN, ITGB4, LAMA5, COL2A1, ITGB6, ITGA1, and TNC.	Curcumin	32-40	integrin subunit alpha 1	Homo sapiens	214-219
34047412-8	2021	Curcumin significantly downregulated Rac1 and Fn14 gene expression and significantly decreased p53, NF-kappaB p65, INF-gamma, and PUMA levels in the cardiac tissue.	Curcumin	0-8	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	95-98
34047412-8	2021	Curcumin significantly downregulated Rac1 and Fn14 gene expression and significantly decreased p53, NF-kappaB p65, INF-gamma, and PUMA levels in the cardiac tissue.	Curcumin	0-8	interferon gamma	Rattus norvegicus	115-124
34047412-9	2021	In addition, curcumin improved oxidative stress indices, DNA damage, and cardiac toxicity markers in the form of lactate dehydrogenase (LD), creatine kinase isoenzyme-MB (CK-MB), and cardiac troponin-I (cTn-I).	Curcumin	13-21	troponin I3, cardiac type	Rattus norvegicus	183-201
34047412-9	2021	In addition, curcumin improved oxidative stress indices, DNA damage, and cardiac toxicity markers in the form of lactate dehydrogenase (LD), creatine kinase isoenzyme-MB (CK-MB), and cardiac troponin-I (cTn-I).	Curcumin	13-21	troponin I3, cardiac type	Rattus norvegicus	203-208
34029211-0	2021	Curcumin inhibits the proliferation and migration of vascular smooth muscle cells by targeting the chemerin / CMKLR1 / LCN2 axis.	Curcumin	0-8	chemokine-like receptor 1	Mus musculus	110-116
34029211-7	2021	Furthermore, we discovered that Lipocalin-2 (LCN2) acts as a key factor involved in CMKLR1-mediated VSMCs proliferation and migration via the p38 / MAPK and Wnt / beta-catenin signaling pathways, and we demonstrated that curcumin inhibits VSMCs proliferation and migration by inhibiting chemerin / CMKLR1 / LCN2, thereby reducing AS progression.	Curcumin	221-229	chemokine-like receptor 1	Mus musculus	84-90
34028111-5	2021	Such pleiotropic nature of curcumin impedes the invasion and proliferation of GC by targeting several oncogenic factors like p23, human epidermal factor receptor2 including Helicobacter pylori.	Curcumin	27-35	prostaglandin E synthase 3	Homo sapiens	125-128
34008959-2	2021	Here, we report that C1, a synthetic derivative of curcumin, strongly inhibited both the aggregation and filament formation of purified tau and protected neuroblastoma cells from the deleterious effects of the tau oligomers.	Curcumin	51-59	microtubule associated protein tau	Homo sapiens	136-139
34008959-2	2021	Here, we report that C1, a synthetic derivative of curcumin, strongly inhibited both the aggregation and filament formation of purified tau and protected neuroblastoma cells from the deleterious effects of the tau oligomers.	Curcumin	51-59	microtubule associated protein tau	Homo sapiens	210-213
33982329-0	2021	A curcumin analogue GL63 inhibits the malignant behaviors of hepatocellular carcinoma by inactivating the JAK2/STAT3 signaling pathway via the circZNF83/miR-324-5p/CDK16 axis.	Curcumin	2-10	Janus kinase 2	Mus musculus	106-110
33982329-0	2021	A curcumin analogue GL63 inhibits the malignant behaviors of hepatocellular carcinoma by inactivating the JAK2/STAT3 signaling pathway via the circZNF83/miR-324-5p/CDK16 axis.	Curcumin	2-10	microRNA 324	Mus musculus	153-160
33985862-0	2021	Corrigendum to "Effects of curcumin based PDT on the viability and the organization of actin in melanotic (A375) and amelanotic melanoma (C32) - in vitro studies" [Biomed.	Curcumin	27-35	chemokine like factor	Homo sapiens	138-141
33662896-2	2021	In this line, we have synthesized thirteen curcumin based derivatives (L1-L13) by multi-component reaction, characterized by IR, 1HNMR, 13C NMR, MS, elemental analysis and evaluated for possible antioxidant properties and alpha-glucosidase (alpha-Glu) and alpha-amylase (alpha-Amy) inhibitory potential.	Curcumin	43-51	mitochondrial ribosomal protein L13	Homo sapiens	74-77
33377585-9	2021	Furthermore, IL-1beta stimulation significantly increased the phosphorylation levels of NF-kappaB p65 and GSK-3beta, and decreased the phosphorylation levels of beta-catenin in articular chondrocytes, and these alterations to the phosphorylation levels were partly reversed by treatment with curcumin.	Curcumin	292-300	catenin beta 1	Rattus norvegicus	161-173
33791015-0	2021	Cytotoxic, chemosensitizing and radiosensitizing effects of curcumin based on thioredoxin system inhibition in breast cancer cells: 2D vs. 3D cell culture system.	Curcumin	60-68	thioredoxin	Homo sapiens	78-89
33791015-5	2021	Curcumin treatment resulted in a reduction of breast cancer cell proliferation and induction of apoptosis, an effect that may be mediated by manipulating Trx system components, mainly Trx expression, and to a lesser extent TrxR1 expression and concentration.	Curcumin	0-8	thioredoxin	Homo sapiens	154-157
33791015-5	2021	Curcumin treatment resulted in a reduction of breast cancer cell proliferation and induction of apoptosis, an effect that may be mediated by manipulating Trx system components, mainly Trx expression, and to a lesser extent TrxR1 expression and concentration.	Curcumin	0-8	thioredoxin	Homo sapiens	184-187
33791015-6	2021	Furthermore, curcumin increased the sensitivity of breast cancer cells to chemotherapy and radiotherapy by reducing Trx and TrxR1 expression levels.	Curcumin	13-21	thioredoxin	Homo sapiens	116-119
33755170-0	2021	Curcumin Enhances the Radiosensitivity of Human Urethral Scar Fibroblasts by Apoptosis, Cell Cycle Arrest and Downregulation of Smad4 via Autophagy.	Curcumin	0-8	ribosomal protein S4 X-linked	Homo sapiens	57-61
33755170-1	2021	The goals of this study were to determine whether curcumin can radiosensitize human urethral scar fibroblasts (HUSFs) and inhibit the synthesis of collagen, and to explore the molecular mechanism.	Curcumin	50-58	ribosomal protein S4 X-linked	Homo sapiens	93-97
33904141-7	2021	Moreover, curcumin and IL-6 were implicated in the endogenous intervention of IL-23 signaling in vivo.	Curcumin	10-18	interleukin 23 subunit alpha	Homo sapiens	78-83
33864298-7	2021	The current study discusses two separate proteomics experiments using BLM and TGF-beta1-treated cells with the proteomics approach, various unique target proteins were identified, and proteomic analysis revealed that curcumin reversed the expressions of unique proteins like DNA topoisomerase 2-alpha (TOP2A), kinesin-like protein (KIF11), centromere protein F (CENPF), and so on BLM or TGF-beta1 injury.	Curcumin	217-225	DNA topoisomerase II alpha	Homo sapiens	275-300
33864298-7	2021	The current study discusses two separate proteomics experiments using BLM and TGF-beta1-treated cells with the proteomics approach, various unique target proteins were identified, and proteomic analysis revealed that curcumin reversed the expressions of unique proteins like DNA topoisomerase 2-alpha (TOP2A), kinesin-like protein (KIF11), centromere protein F (CENPF), and so on BLM or TGF-beta1 injury.	Curcumin	217-225	DNA topoisomerase II alpha	Homo sapiens	302-307
33864298-7	2021	The current study discusses two separate proteomics experiments using BLM and TGF-beta1-treated cells with the proteomics approach, various unique target proteins were identified, and proteomic analysis revealed that curcumin reversed the expressions of unique proteins like DNA topoisomerase 2-alpha (TOP2A), kinesin-like protein (KIF11), centromere protein F (CENPF), and so on BLM or TGF-beta1 injury.	Curcumin	217-225	kinesin family member 11	Homo sapiens	332-337
33935747-0	2021	Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1alpha/VEGF/TFEB-Activated Angiogenesis.	Curcumin	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	88-98
33937075-0	2021	The Diarylheptanoid Curcumin Induces MYC Inhibition and Cross-Links This Oncoprotein to the Coactivator TRRAP.	Curcumin	20-28	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	37-40
33937075-6	2021	Here, we have tested curcumin"s effect on MYC-dependent cell transformation and transcriptional activation, and found that this natural compound interferes with both of these MYC activities.	Curcumin	21-29	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	42-45
33937075-6	2021	Here, we have tested curcumin"s effect on MYC-dependent cell transformation and transcriptional activation, and found that this natural compound interferes with both of these MYC activities.	Curcumin	21-29	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	175-178
33937075-7	2021	Furthermore, in curcumin-treated cells, the endogenous 60-kDa MYC protein is covalently and specifically cross-linked to one of its transcriptional interaction partners, namely the 434-kDa transformation/transcription domain associated protein (TRRAP).	Curcumin	16-24	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	62-65
33937075-11	2021	Curcumin-mediated covalent binding of MYC to TRRAP reduces the protein amounts of both interaction partners but does not downregulate TP53, so that the growth-arresting effect of wild type TP53 could prevail.	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	38-41
33937075-13	2021	With regard to their broad impact in cancer, our findings contribute to explain the pleiotropic functions of curcumin, and suggest that this natural spice, or more bioavailable derivatives thereof, may constitute useful adjuvants in the therapy of MYC-dependent and TRRAP-associated human tumors.	Curcumin	109-117	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	248-251
33927630-12	2021	The possible interventions by curcumin, resveratrol, cannabidiol, ginsenosides, flavonoids and sulforaphane on microglia specific protein Iba1 suggest possibility of natural products mediated regulation of microglia phenotypes and its functions to control redox imbalance and neuroinflammation in management of Alzheimer"s, Parkinson"s and Multiple Sclerosis for microglia-mediated therapeutics.	Curcumin	30-38	allograft inflammatory factor 1	Homo sapiens	138-142
33411217-1	2021	The present study was designed to evaluate the role of cAMP-PKA-CREB signaling in mediating the neuroprotective effects of curcumin against DCAA-induced oxidative stress, inflammation and impaired synaptic plasticity in rats.	Curcumin	123-131	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	60-63
33411217-1	2021	The present study was designed to evaluate the role of cAMP-PKA-CREB signaling in mediating the neuroprotective effects of curcumin against DCAA-induced oxidative stress, inflammation and impaired synaptic plasticity in rats.	Curcumin	123-131	cAMP responsive element binding protein 1	Rattus norvegicus	64-68
33411217-8	2021	Conversely, various doses of curcumin attenuated DCAA-induced oxidative stress, inflammation response and impaired synaptic plasticity, while elevating cAMP, PKA, p-CREB, BDNF, PSD-95, SYP levels.	Curcumin	29-37	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	158-161
33411217-8	2021	Conversely, various doses of curcumin attenuated DCAA-induced oxidative stress, inflammation response and impaired synaptic plasticity, while elevating cAMP, PKA, p-CREB, BDNF, PSD-95, SYP levels.	Curcumin	29-37	cAMP responsive element binding protein 1	Rattus norvegicus	165-169
33411217-9	2021	Thus, curcumin could activate the cAMP-PKA-CREB signaling pathway, conferring neuroprotection against DCAA-induced neurotoxicity.	Curcumin	6-14	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	39-42
33411217-9	2021	Thus, curcumin could activate the cAMP-PKA-CREB signaling pathway, conferring neuroprotection against DCAA-induced neurotoxicity.	Curcumin	6-14	cAMP responsive element binding protein 1	Rattus norvegicus	43-47
33649826-6	2021	Western blotting results indicated that curcumin dose-dependently suppressed the phosphorylation of AKT, PRAS40, 4E-BP1, P70S6K, RAF-1 and p27 in AML cell lines (ML-2 and OCI-AML5).	Curcumin	40-48	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	113-119
33649826-6	2021	Western blotting results indicated that curcumin dose-dependently suppressed the phosphorylation of AKT, PRAS40, 4E-BP1, P70S6K, RAF-1 and p27 in AML cell lines (ML-2 and OCI-AML5).	Curcumin	40-48	ribosomal protein S6 kinase B1	Homo sapiens	121-127
33649826-7	2021	It was also demonstrated that curcumin regulated the cell cycle- and apoptosis-related proteins (cyclin D1, p21, Bcl2, cleaved-caspase-3 and cleaved-PARP), leading to cell cycle arrest and apoptosis in both ML-2 and OCI-AML5 cells.	Curcumin	30-38	H3 histone pseudogene 16	Homo sapiens	108-111
33753114-8	2021	Curcumin retarded Hep3B cell growth and reduced surface PD-L1 expression in Hep3B cells.	Curcumin	0-8	CD274 molecule	Homo sapiens	56-61
32694760-6	2021	Furthermore, in bleomycin-treated mice, the upregulated protein level of HGF in lungs by oral curcumin was highly correlated with its anti-PF effect, which was further confirmed by coadministration of c-Met inhibitor SU11274.	Curcumin	94-102	met proto-oncogene	Mus musculus	201-206
33574907-4	2021	The present study assessed whether CCM exerted its anti-neuroglioma effects on U87 cells via inhibition of HSP60/TLR-4 signaling, similar to that in microglia.	Curcumin	35-38	toll like receptor 4	Homo sapiens	113-118
33574907-9	2021	Based on the results of the present study, CCM may exert its anti-tumor effects in U87 cells by inhibiting the HSP60/TLR-4/MYD88/NF-kappaB pathway and inducing tumor cell apoptosis.	Curcumin	43-46	toll like receptor 4	Homo sapiens	117-122
33495830-8	2021	HMPH significantly inhibited the translocation of p65 NF-kappaB into the nucleus to a greater extent than curcumin, thus indicating that HMPH has more potent anti-inflammatory activity than curcumin.	Curcumin	190-198	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	50-63
33574925-0	2021	Curcumin suppresses colorectal tumorigenesis via the Wnt/beta-catenin signaling pathway by downregulating Axin2.	Curcumin	0-8	catenin beta 1	Homo sapiens	57-69
33574925-0	2021	Curcumin suppresses colorectal tumorigenesis via the Wnt/beta-catenin signaling pathway by downregulating Axin2.	Curcumin	0-8	axin 2	Homo sapiens	106-111
33562625-5	2021	Overall, this probe delivery via inhalation method is also applicable to other Abeta-binding molecules, such as Congo red, curcumin, and thioflavin T.	Curcumin	123-131	amyloid beta (A4) precursor protein	Mus musculus	79-84
33597887-7	2020	In addition, curcumin significantly inhibited the activation of the JAK1/STAT5 signaling pathway, downregulation of JAK1, STAT5, and p-STAT5 proteins in colon tissue, and upregulation of PIAS1 proteins.	Curcumin	13-21	signal transducer and activator of transcription 5A	Homo sapiens	73-78
33597887-7	2020	In addition, curcumin significantly inhibited the activation of the JAK1/STAT5 signaling pathway, downregulation of JAK1, STAT5, and p-STAT5 proteins in colon tissue, and upregulation of PIAS1 proteins.	Curcumin	13-21	signal transducer and activator of transcription 5A	Homo sapiens	122-127
33597887-7	2020	In addition, curcumin significantly inhibited the activation of the JAK1/STAT5 signaling pathway, downregulation of JAK1, STAT5, and p-STAT5 proteins in colon tissue, and upregulation of PIAS1 proteins.	Curcumin	13-21	signal transducer and activator of transcription 5A	Homo sapiens	122-127
33597887-7	2020	In addition, curcumin significantly inhibited the activation of the JAK1/STAT5 signaling pathway, downregulation of JAK1, STAT5, and p-STAT5 proteins in colon tissue, and upregulation of PIAS1 proteins.	Curcumin	13-21	protein inhibitor of activated STAT 1	Homo sapiens	187-192
33597887-8	2020	These results suggested that curcumin effectively regulated the differentiation of naive, TCM, and TEM cells in the peripheral blood to alleviate DSS-induced experimental colitis, which might be related to the inhibition of JAK1/STAT5 signaling activity.	Curcumin	29-37	signal transducer and activator of transcription 5A	Homo sapiens	229-234
33298267-4	2021	This method allows for the determination of curcumin in the range of 0.1-10 mug mL-1 and the detection limit is 21 ng mL-1.	Curcumin	44-52	L1 cell adhesion molecule	Mus musculus	80-84
33298267-4	2021	This method allows for the determination of curcumin in the range of 0.1-10 mug mL-1 and the detection limit is 21 ng mL-1.	Curcumin	44-52	L1 cell adhesion molecule	Mus musculus	118-122
33096358-0	2021	Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	110-114
33096358-7	2021	Furthermore, curcumin significantly increased the nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) and consequently upregulated the expression of heme oxygenase 1 (HO-1) under HgCl2 treatment.	Curcumin	13-21	heme oxygenase 1	Homo sapiens	164-180
33096358-7	2021	Furthermore, curcumin significantly increased the nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) and consequently upregulated the expression of heme oxygenase 1 (HO-1) under HgCl2 treatment.	Curcumin	13-21	heme oxygenase 1	Homo sapiens	182-186
33096358-8	2021	Meanwhile, inhibition of HO-1 by zinc protoporphyria could abolish the cytoprotective effects of curcumin in HgCl2-treated L02 hepatocytes.	Curcumin	97-105	heme oxygenase 1	Homo sapiens	25-29
33096358-9	2021	In conclusion, our data identify that curcumin could enhance Nrf2-mediated HO-1 to upregulate antioxidant ability, which might be associate with CYP450 signaling to suppress liver damage induced by HgCl2.	Curcumin	38-46	heme oxygenase 1	Homo sapiens	75-79
33387125-0	2021	Curcumin Chemoprevention Reduces the Incidence of Braf Mutant Colorectal Cancer in a Preclinical Study.	Curcumin	0-8	Braf transforming gene	Mus musculus	50-54
33387125-4	2021	In this preclinical study, we investigated the ability of an improved formulation of curcumin to reduce the incidence of Braf mutant carcinoma.	Curcumin	85-93	Braf transforming gene	Mus musculus	121-125
33387125-5	2021	AIM: To investigate curcumin as a chemopreventive for Braf mutant colorectal cancer in a preclinical study utilizing a murine model of serrated neoplasia.	Curcumin	20-28	Braf transforming gene	Mus musculus	54-58
33387125-6	2021	METHODS: An intestine-specific Braf mutant murine model (BrafV637E/+/Villin-CreERT2/+) was administered curcumin micelles (240 mg/kg, n = 69) in normal drinking water.	Curcumin	104-112	Braf transforming gene	Mus musculus	31-35
33387125-11	2021	We found that curcumin significantly reduces the risk of developing Braf mutant colorectal cancer.	Curcumin	14-22	Braf transforming gene	Mus musculus	68-72
33747866-0	2021	The Target Differences of Anti-Tumorigenesis Potential of Curcumin and its Analogues Against HER-2 Positive and Triple-Negative Breast Cancer Cells.	Curcumin	58-66	erb-b2 receptor tyrosine kinase 2	Mus musculus	93-98
33747866-1	2021	Purpose: The current study aims to evaluate the in vitro cytotoxic and cell migration effects of synthetic curcumin and its analogues on HER2 and nuclear factor kappa B (NFkappaB) pathways, as well as the in vivo inhibitory effect on cancer growth of metastatic breast cancer.	Curcumin	107-115	erb-b2 receptor tyrosine kinase 2	Mus musculus	137-141
33202358-0	2021	Curcumin promotes osteogenic differentiation of human periodontal ligament stem cells by inducting EGR1 expression.	Curcumin	0-8	early growth response 1	Homo sapiens	99-103
33202358-10	2021	Curcumin 10 mumol/L treatment maximal promoting the cells viability, ALP activities, mineralization, and levels of Runx2, OC, OPN, Collagen I and EGR-1 in hPDLSCs.	Curcumin	0-8	secreted phosphoprotein 1	Homo sapiens	126-129
33202358-10	2021	Curcumin 10 mumol/L treatment maximal promoting the cells viability, ALP activities, mineralization, and levels of Runx2, OC, OPN, Collagen I and EGR-1 in hPDLSCs.	Curcumin	0-8	early growth response 1	Homo sapiens	146-151
33202358-11	2021	EGR-1 siRNA transfection inversed Curcumin"s promoting effect on ALP activities, mineralization, and levels of Runx2, OC, OPN, Collagen I and EGR-1 in hPDLSCs.	Curcumin	34-42	early growth response 1	Homo sapiens	0-5
33202358-11	2021	EGR-1 siRNA transfection inversed Curcumin"s promoting effect on ALP activities, mineralization, and levels of Runx2, OC, OPN, Collagen I and EGR-1 in hPDLSCs.	Curcumin	34-42	secreted phosphoprotein 1	Homo sapiens	122-125
33202358-12	2021	While the EGR-1 plasmid transfection enhanced Curcumin"s promoting effect on these parameters of hPDLSCs.	Curcumin	46-54	early growth response 1	Homo sapiens	10-15
31820701-0	2021	Network Pharmacology Approach uncovering Pathways involved in targeting Hsp90 through Curcumin and Epigallocatechin to control Inflammation.	Curcumin	86-94	heat shock protein 90 alpha family class A member 1	Homo sapiens	72-77
31820701-4	2021	Curcumin and EGC were also found to bind -N and -C terminal domain of Hsp90 respectively.	Curcumin	0-8	heat shock protein 90 alpha family class A member 1	Homo sapiens	70-75
31820701-6	2021	Hsp90 associated gene targets of Curcumin and EGC were collected from databases, and gene ontology studies were done.	Curcumin	33-41	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
31820701-8	2021	Protein interaction network was constructed by cytoscape, and networks of Hsp90, Curcumin and EGC were merged to get common genes involved in Pkcdelta-Nrf2 and Tlr4 pathway.	Curcumin	81-89	toll like receptor 4	Homo sapiens	160-164
31820701-10	2021	Main proteins involved were identified as key regulators in Pkcdelta-Nrf2 and Tlr4 pathway for controlling expression of Hsp90 from Curcumin and EGC in inflammation.	Curcumin	132-140	toll like receptor 4	Homo sapiens	78-82
31820701-10	2021	Main proteins involved were identified as key regulators in Pkcdelta-Nrf2 and Tlr4 pathway for controlling expression of Hsp90 from Curcumin and EGC in inflammation.	Curcumin	132-140	heat shock protein 90 alpha family class A member 1	Homo sapiens	121-126
31820701-11	2021	Docking was performed on main proteins, Hsp90, Pkcdelta and Tlr4 with Curcumin and EGC, significant binding energy was obtained for docked complexes.	Curcumin	70-78	heat shock protein 90 alpha family class A member 1	Homo sapiens	40-45
31820701-11	2021	Docking was performed on main proteins, Hsp90, Pkcdelta and Tlr4 with Curcumin and EGC, significant binding energy was obtained for docked complexes.	Curcumin	70-78	toll like receptor 4	Homo sapiens	60-64
31820701-13	2021	Present study is an attempt to unravel common pathways mediated in intervention of Curcumin and EGC for suppression of Hsp90 associated with inflammation.	Curcumin	83-91	heat shock protein 90 alpha family class A member 1	Homo sapiens	119-124
33457406-4	2020	Under simulated hypoxic conditions, curcumin combined with Glu-GNPs can significantly improve the ROS level of MCF-7 and MDA-MB-231 mammospheres; reduce the expression of HIF-1alpha and HSP90, thereby inhibiting the tumor cells" own stress ability; promote the apoptosis of tumor stem cells; and enhance the sensitivity of radiotherapy.	Curcumin	36-44	heat shock protein 90 alpha family class A member 1	Homo sapiens	186-191
33414789-10	2020	Insulin turbidimetric assays demonstrated that curcumin is a potent PDI inhibitor and pre-treatment of mast cells with curcumin or established PDI inhibitors such as bacitracin, rutin or PACMA-31, resulted in the suppression of IgE-mediated activation and the secretion of various cytokines.	Curcumin	47-55	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	68-71
33414789-10	2020	Insulin turbidimetric assays demonstrated that curcumin is a potent PDI inhibitor and pre-treatment of mast cells with curcumin or established PDI inhibitors such as bacitracin, rutin or PACMA-31, resulted in the suppression of IgE-mediated activation and the secretion of various cytokines.	Curcumin	47-55	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	143-146
33350580-9	2020	In conclusion, oral administration of curcumin shows hepatoprotective effects against APAP-overdose induced hepatic damage in normal and gamma-irradiated rats through prospective regulation of the therapeutic targets CYP2E1, Nrf2, and NF-kappaB, via organizing the miR-122 and miR-802 gene expression.	Curcumin	38-46	microRNA 122	Rattus norvegicus	265-272
33058920-6	2020	Molecular docking and other studies confirmed that curcumin could bind to and upregulate the expression of TET2 and TET3 with hydrogen bonds and arene-H bonds, suggesting that demethylation of RB1 was attributed to reactivation of the demethylation enzymes TET2 and TET3 after curcumin treatment.	Curcumin	51-59	tet methylcytosine dioxygenase 2	Mus musculus	107-111
33058920-6	2020	Molecular docking and other studies confirmed that curcumin could bind to and upregulate the expression of TET2 and TET3 with hydrogen bonds and arene-H bonds, suggesting that demethylation of RB1 was attributed to reactivation of the demethylation enzymes TET2 and TET3 after curcumin treatment.	Curcumin	51-59	tet methylcytosine dioxygenase 2	Mus musculus	257-261
33058920-6	2020	Molecular docking and other studies confirmed that curcumin could bind to and upregulate the expression of TET2 and TET3 with hydrogen bonds and arene-H bonds, suggesting that demethylation of RB1 was attributed to reactivation of the demethylation enzymes TET2 and TET3 after curcumin treatment.	Curcumin	277-285	tet methylcytosine dioxygenase 2	Mus musculus	107-111
32893845-10	2020	Curcumin incubation significantly downregulated expression levels of DNA methyltransferase1 (DNMT1), DNMT3a, and the methylation levels of the cdx2 promoter in a concentration-dependent manner.	Curcumin	0-8	DNA methyltransferase 3 alpha	Homo sapiens	101-107
32893845-11	2020	The expression levels of N-cadherin, Vimentin, Wnt3a, Snail1, and Twist, as well as the nuclear translocation levels of ss-catenin, were reduced in a curcumin concentration-dependent manner.	Curcumin	150-158	vimentin	Homo sapiens	37-45
32887024-0	2020	Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-Wnt signal pathway to inhibit the EMT progress.	Curcumin	0-8	tet methylcytosine dioxygenase 1	Homo sapiens	85-89
32887024-10	2020	The expression of TET1 and NKD2 was greatly inhibited by high dosage of curcumin.	Curcumin	72-80	tet methylcytosine dioxygenase 1	Homo sapiens	18-22
32887024-10	2020	The expression of TET1 and NKD2 was greatly inhibited by high dosage of curcumin.	Curcumin	72-80	NKD inhibitor of WNT signaling pathway 2	Homo sapiens	27-31
32887024-12	2020	The inhibitory effects of curcumin on WNT signal pathway and EMT progress were verified to be consistent with Pax-6, TET1 and NKD2.	Curcumin	26-34	tet methylcytosine dioxygenase 1	Homo sapiens	117-121
32887024-12	2020	The inhibitory effects of curcumin on WNT signal pathway and EMT progress were verified to be consistent with Pax-6, TET1 and NKD2.	Curcumin	26-34	NKD inhibitor of WNT signaling pathway 2	Homo sapiens	126-130
32887024-13	2020	CONCLUSION: Curcumin might exert anti-resistant effect of 5-FU on HCT-116 cells by regulating the TET1-NKD2-WNT signal pathway to inhibit the EMT progress.	Curcumin	12-20	tet methylcytosine dioxygenase 1	Homo sapiens	98-102
32887024-13	2020	CONCLUSION: Curcumin might exert anti-resistant effect of 5-FU on HCT-116 cells by regulating the TET1-NKD2-WNT signal pathway to inhibit the EMT progress.	Curcumin	12-20	NKD inhibitor of WNT signaling pathway 2	Homo sapiens	103-107
32500379-9	2020	Therapies with anti-viral properties that raise HO-1 include certain anesthetics (sevoflurane or isoflurane), hemin, estrogen, statins, curcumin, resveratrol, and melatonin.	Curcumin	136-144	heme oxygenase 1	Homo sapiens	48-52
32464442-9	2020	Furthermore, pretreatment of curcumin with arsenic expressively alleviated arsenic-induced toxicity and cell death by reversing the expressions of proteins; mTOR, Akt, Nrf2, ERK1, Bcl-x, Xiap, ULK, LC3, p53, Bax, cytochrome c, caspase 9 and cleaved caspase 3.	Curcumin	29-37	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	203-206
32464442-9	2020	Furthermore, pretreatment of curcumin with arsenic expressively alleviated arsenic-induced toxicity and cell death by reversing the expressions of proteins; mTOR, Akt, Nrf2, ERK1, Bcl-x, Xiap, ULK, LC3, p53, Bax, cytochrome c, caspase 9 and cleaved caspase 3.	Curcumin	29-37	BCL2 associated X, apoptosis regulator	Rattus norvegicus	208-211
32765696-0	2020	Curcumin protects bone biomechanical properties and microarchitecture in type 2 diabetic rats with osteoporosis via the TGFbeta/Smad2/3 pathway.	Curcumin	0-8	SMAD family member 2	Rattus norvegicus	128-135
32782494-9	2020	However, pretreatment with curcumin increased the expression of ABCA1 and cholesterol efflux and suppressed secretion of TNF-alpha, MCP-1 and Il-6.	Curcumin	27-35	C-C motif chemokine ligand 2	Homo sapiens	132-137
32782494-11	2020	Curcumin promoted cholesterol efflux by suppressing the TLR4/NF-kappaB/miR33a signaling pathway, and reduced the formation of foam cells and the secretion of inflammatory factors.	Curcumin	0-8	toll like receptor 4	Homo sapiens	56-60
32782494-11	2020	Curcumin promoted cholesterol efflux by suppressing the TLR4/NF-kappaB/miR33a signaling pathway, and reduced the formation of foam cells and the secretion of inflammatory factors.	Curcumin	0-8	microRNA 33a	Homo sapiens	71-77
32585605-7	2020	For assessing working memory and long-term potentiation, the double Y-maze test and Schaffer collateral-CA1 in vivo electrophysiological recording were performed, respectively Our results showed that curcumin and hesperidin decreased TNF-alpha, IL-10, and TLR4 protein expression and reversed memory dysfunction.	Curcumin	200-208	interleukin 10	Rattus norvegicus	245-250
32830149-6	2020	In addition, IGF-1 treatment rescued the curcumin-induced down-regulated expression of p- PI3K, p-Akt, and VEGF, and VEGF overexpression counteracted the inhibitory effect of curcumin on brain HI damage.	Curcumin	41-49	insulin-like growth factor 1	Rattus norvegicus	13-18
32830149-6	2020	In addition, IGF-1 treatment rescued the curcumin-induced down-regulated expression of p- PI3K, p-Akt, and VEGF, and VEGF overexpression counteracted the inhibitory effect of curcumin on brain HI damage.	Curcumin	41-49	vascular endothelial growth factor A	Rattus norvegicus	107-111
32830149-6	2020	In addition, IGF-1 treatment rescued the curcumin-induced down-regulated expression of p- PI3K, p-Akt, and VEGF, and VEGF overexpression counteracted the inhibitory effect of curcumin on brain HI damage.	Curcumin	41-49	vascular endothelial growth factor A	Rattus norvegicus	117-121
32830149-6	2020	In addition, IGF-1 treatment rescued the curcumin-induced down-regulated expression of p- PI3K, p-Akt, and VEGF, and VEGF overexpression counteracted the inhibitory effect of curcumin on brain HI damage.	Curcumin	175-183	insulin-like growth factor 1	Rattus norvegicus	13-18
32830149-6	2020	In addition, IGF-1 treatment rescued the curcumin-induced down-regulated expression of p- PI3K, p-Akt, and VEGF, and VEGF overexpression counteracted the inhibitory effect of curcumin on brain HI damage.	Curcumin	175-183	vascular endothelial growth factor A	Rattus norvegicus	117-121
32830149-7	2020	Overall, pretreatment with curcumin protected against brain HI damage by targeting VEGF via the PI3K/Akt signaling pathway in neonatal rats.	Curcumin	27-35	vascular endothelial growth factor A	Rattus norvegicus	83-87
32445778-10	2020	In addition, we administered curcumin to nude mice and found that curcumin decreased the tumor volume, caused necrosis of tumor tissue, and significantly enhanced the PTEN and p53 expression in vivo.	Curcumin	66-74	transformation related protein 53, pseudogene	Mus musculus	176-179
32445778-11	2020	CONCLUSIONS: These results indicated that curcumin inhibited proliferation by decreasing the p-AKT/p-mTOR pathway, and promoted apoptosis by increasing the PTEN and p53 expression.	Curcumin	42-50	mechanistic target of rapamycin kinase	Mus musculus	101-105
32445778-11	2020	CONCLUSIONS: These results indicated that curcumin inhibited proliferation by decreasing the p-AKT/p-mTOR pathway, and promoted apoptosis by increasing the PTEN and p53 expression.	Curcumin	42-50	transformation related protein 53, pseudogene	Mus musculus	165-168
32757174-11	2021	While KCNQ1OT1 overexpression removed the effect of curcumin on HCT8/DDP cells via miR-497/ Bcl-2 axis.	Curcumin	52-60	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	6-14
32757174-12	2021	Finally, the in vivo experiments showed that the inhibitory effect of curcumin on the growth of cisplatin-resistant CRC cells was reserved by the ectopic expression of KCNQ1OT1.	Curcumin	70-78	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	168-176
32757174-14	2021	Administration of curcumin could effectively downregulate KCNQ1OT1 expression, thus reversing cisplatin resistance in CRC cells.	Curcumin	18-26	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	58-66
32759757-0	2020	The Curcumin Analogue, EF-24, Triggers p38 MAPK-Mediated Apoptotic Cell Death via Inducing PP2A-Modulated ERK Deactivation in Human Acute Myeloid Leukemia Cells.	Curcumin	4-12	protein phosphatase 2 phosphatase activator	Homo sapiens	91-95
32615888-5	2020	Western blot analysis indicated that Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3, p-65-NF-kappaB and cell apoptosis pathways were activated by LPS but suppressed by Curcumin.	Curcumin	200-208	Janus kinase 2	Mus musculus	37-57
32615888-5	2020	Western blot analysis indicated that Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3, p-65-NF-kappaB and cell apoptosis pathways were activated by LPS but suppressed by Curcumin.	Curcumin	200-208	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	117-131
32615888-6	2020	Mice SAKI model further indicated that the serum Cystatin C (Cys-C), creatinine (Cr) and blood urea nitrogen (BUN) were increased within 24 h of model construction while those indicators were decreased at 48 h. Pretreated with Curcumin, NF-kappaB inhibitor (PDTC) or JAK2 inhibitor (AG-490) could weaken the renal histological injury and the increased serum Cys-C, Cr and BUN, IL-6 and TNF-alpha induced by CLP.	Curcumin	227-235	Janus kinase 2	Mus musculus	267-271
32615888-7	2020	Moreover, PDTC, AG-490 and Curcumin all significantly reversed the previously increased expressions of p-JAK2/STAT3, p-p65 and proapoptotic proteins in the mice with AKI.	Curcumin	27-35	Janus kinase 2	Mus musculus	105-109
32615888-7	2020	Moreover, PDTC, AG-490 and Curcumin all significantly reversed the previously increased expressions of p-JAK2/STAT3, p-p65 and proapoptotic proteins in the mice with AKI.	Curcumin	27-35	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	119-122
32615888-8	2020	The present study revealed that Curcumin attenuated SAKI through inhibiting NF-kappaB and JAK2/STAT3 signaling pathways, and proposed that Curcumin could be a potential therapeutic agent for treating SAKI.	Curcumin	32-40	Janus kinase 2	Mus musculus	90-94
32615888-8	2020	The present study revealed that Curcumin attenuated SAKI through inhibiting NF-kappaB and JAK2/STAT3 signaling pathways, and proposed that Curcumin could be a potential therapeutic agent for treating SAKI.	Curcumin	139-147	Janus kinase 2	Mus musculus	90-94
32626956-11	2020	In addition, the curcumin-induced decreased expression levels of beta-catenin, cyclin D1 and c-Myc were rescued following the genetic knockdown of miR-192-5p.	Curcumin	17-25	catenin beta 1	Homo sapiens	65-77
32626956-11	2020	In addition, the curcumin-induced decreased expression levels of beta-catenin, cyclin D1 and c-Myc were rescued following the genetic knockdown of miR-192-5p.	Curcumin	17-25	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	93-98
32626956-12	2020	In conclusion, these findings suggested that the upregulation of miR-192-5p may underlie the inhibitory effects of curcumin on NSCLC cells through targeting c-Myc and inactivating the Wnt/beta-catenin signaling pathway.	Curcumin	115-123	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	157-162
32626956-12	2020	In conclusion, these findings suggested that the upregulation of miR-192-5p may underlie the inhibitory effects of curcumin on NSCLC cells through targeting c-Myc and inactivating the Wnt/beta-catenin signaling pathway.	Curcumin	115-123	catenin beta 1	Homo sapiens	188-200
32141025-6	2020	RESULTS: Curcumin augments TRAIL-apoptotic signaling in leukemic cells by upregulating the expression of DR4 and DR5 along with suppression of cFLIP and anti-apoptotic proteins Mcl-1, Bcl-xl, and XIAP.	Curcumin	9-17	TNF receptor superfamily member 10b	Homo sapiens	113-116
32141025-6	2020	RESULTS: Curcumin augments TRAIL-apoptotic signaling in leukemic cells by upregulating the expression of DR4 and DR5 along with suppression of cFLIP and anti-apoptotic proteins Mcl-1, Bcl-xl, and XIAP.	Curcumin	9-17	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	177-182
32780358-7	2021	Thus, based on the obtained results, the expression of c-kit, STRA8, and PCNA genes was significantly increased in treatment groups by curcumin-loaded iron particles compared with scrotal hyperthermia-induced mice.	Curcumin	135-143	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	55-60
32780358-7	2021	Thus, based on the obtained results, the expression of c-kit, STRA8, and PCNA genes was significantly increased in treatment groups by curcumin-loaded iron particles compared with scrotal hyperthermia-induced mice.	Curcumin	135-143	stimulated by retinoic acid gene 8	Mus musculus	62-67
33096358-10	2021	The present study further enriches and perfects the mechanism theory of HgCl2 toxicity and suggest that the CYP450 signaling and Nrf2/HO-1 pathway is important in shedding light on curcumin"s hepatoprotective effects in HgCl2 toxicity.	Curcumin	181-189	heme oxygenase 1	Homo sapiens	134-138
33183601-3	2021	Composites of GPs with incorporated curcumin showed promising results with the capability to lower symptoms of colitis and significantly decrease the production of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and the activity of MPO, as well.	Curcumin	36-44	myeloperoxidase	Rattus norvegicus	238-241
33486250-6	2021	Here we investigated how curcumin affects the p53-p21 pathway in fluoride toxicity.	Curcumin	25-33	H3 histone pseudogene 16	Homo sapiens	50-53
33486250-13	2021	However, curcumin itself significantly increased Ac-p53 and upregulated p21 protein levels to suppress cell proliferation in a dose-dependent manner.	Curcumin	9-17	H3 histone pseudogene 16	Homo sapiens	72-75
33486250-14	2021	Curcumin suppressed fluoride-induced phosphorylation of p21 and increased p21 levels within the nuclear fraction.	Curcumin	0-8	H3 histone pseudogene 16	Homo sapiens	56-59
33486250-14	2021	Curcumin suppressed fluoride-induced phosphorylation of p21 and increased p21 levels within the nuclear fraction.	Curcumin	0-8	H3 histone pseudogene 16	Homo sapiens	74-77
33486250-16	2021	These results suggest that curcumin-induced Ac-p53 and p21 led to cell cycle arrest, while curcumin attenuated fluoride-mediated apoptosis via activation of Akt and suppressed fluoride-mediated DNA damage.	Curcumin	27-35	H3 histone pseudogene 16	Homo sapiens	55-58
33250162-4	2021	Under these conditions, four curcuminoids including curcumin, demethoxy curcumin (DMC), bisdemethoxy curcumin (BDMC) and demethyl curcumin (DEC) could be well separated within 18 min, and the detection limits (LOD, based on S/N=3) were calculated to be 71, 60, 22, and 147 pg mL-1, respectively.	Curcumin	29-37	L1 cell adhesion molecule	Mus musculus	276-280
33397249-8	2021	Curcumin and nano-curcumin supplementation also improved significant changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in comparison to the placebo (p<0.05).	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	281-289
32777138-7	2021	Furthermore, curcumin treatment reduced MMP1 expression but upregulated the immunomodulatory gene IDO1 expression.	Curcumin	13-21	matrix metallopeptidase 1	Homo sapiens	40-44
32777138-7	2021	Furthermore, curcumin treatment reduced MMP1 expression but upregulated the immunomodulatory gene IDO1 expression.	Curcumin	13-21	indoleamine 2,3-dioxygenase 1	Homo sapiens	98-102
33188859-0	2021	Curcumin analogs exhibit anti-cancer activity by selectively targeting G-quadruplex forming c-myc promoter sequence.	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	92-97
33188859-4	2021	Herein, we investigated the interaction of Curcumin and its synthetic analogs with G-quadruplex DNA formed at the c-myc promoter by using various biophysical and biochemical assays.	Curcumin	43-51	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	114-119
33188859-7	2021	Our study provides an expanded overview of the anti-cancer effect of a new Curcumin analog via targeting G-quadruplex structures formed at the promoter region of the human c-myc gene.	Curcumin	75-83	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	172-177
33068823-3	2021	We aimed to investigate Glypican-3-targeted, curcumin-loaded microbubbles (GPC3-CUR-MBs)-mediated SPDT in liver cancer cells in vitro and in vivo.	Curcumin	45-53	glypican 3	Homo sapiens	24-34
33068823-3	2021	We aimed to investigate Glypican-3-targeted, curcumin-loaded microbubbles (GPC3-CUR-MBs)-mediated SPDT in liver cancer cells in vitro and in vivo.	Curcumin	45-53	glypican 3	Homo sapiens	75-79
32392119-0	2021	Possible Protective Effects of Curcumin via Modulating of Androgen Receptor (AR) and Oct2 Gene Alterations in Cisplatin-Induced Testicular Toxicity in Rat.	Curcumin	31-39	solute carrier family 22 member 2	Rattus norvegicus	85-89
32392119-2	2021	This study aimed to investigate the possible role of androgens, androgen receptor, and organic cation transporter 2 (OCT2) in the protective effects of curcumin on cisplatin-induced testicular toxicity.	Curcumin	152-160	solute carrier family 22 member 2	Rattus norvegicus	87-115
32392119-2	2021	This study aimed to investigate the possible role of androgens, androgen receptor, and organic cation transporter 2 (OCT2) in the protective effects of curcumin on cisplatin-induced testicular toxicity.	Curcumin	152-160	solute carrier family 22 member 2	Rattus norvegicus	117-121
32657143-7	2021	Meanwhile, the combination showed a synergistic effect within 48 h. In the curcumin treated group, the expression of Bcl-2 and hTERT genes diminished.	Curcumin	75-83	telomerase reverse transcriptase	Homo sapiens	127-132
33380787-4	2020	Methods: Here, we prepared liposomes loaded with curcumin and cyclopamine to inhibit HSC activation.	Curcumin	49-57	fucosyltransferase 1 (H blood group)	Homo sapiens	85-88
32623920-6	2020	We further showed that H2O2-induced oxidative stress was reduced by curcumin via the Nrf2/HO-1 pathway in human neuroblastoma cells.	Curcumin	68-76	heme oxygenase 1	Homo sapiens	90-94
32623920-7	2020	In addition, we showed that curcumin induced the degradation of amyloidogenic proteins, including amyloid-beta precursor protein and alpha-synuclein, through the TFEB-autophagy/lysosomal pathway.	Curcumin	28-36	synuclein alpha	Homo sapiens	133-148
33129099-10	2020	CONCLUSION: Nano-curcumin, as an anti-inflammatory herbal based agent, may be able to modulate the increased rate of inflammatory cytokines especially IL-1beta and IL-6 mRNA expression and cytokine secretion in COVID-19 patients, which may cause an improvement in clinical manifestation and overall recovery.	Curcumin	17-25	interleukin 1 alpha	Homo sapiens	151-159
33489037-7	2020	The highest SOD activity as well as the lowest MPO and IL-1beta levels were observed in the ADSCs-curcumin-loaded collagen scaffold group.	Curcumin	98-106	myeloperoxidase	Rattus norvegicus	47-50
32515250-0	2020	Curcumin potentiates laryngeal squamous carcinoma radiosensitivity via NF-KappaB inhibition by suppressing IKKgamma expression.	Curcumin	0-8	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	107-115
32515250-2	2020	However, the role and mechanism of curcumin on radiosensitivity in laryngeal squamous cell cancer (LSCC) is largely unknown.Objective: The aim of our study is to explore the role of IKKgamma-NF-kappaB signaling in curcumin enhancing LSCC cell radiosensitivity in vitro.Materials and methods: Curcumin and X-ray were used to induce cell DNA damage and apoptosis, or inhibit cell clone formation.	Curcumin	214-222	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	182-190
32515250-2	2020	However, the role and mechanism of curcumin on radiosensitivity in laryngeal squamous cell cancer (LSCC) is largely unknown.Objective: The aim of our study is to explore the role of IKKgamma-NF-kappaB signaling in curcumin enhancing LSCC cell radiosensitivity in vitro.Materials and methods: Curcumin and X-ray were used to induce cell DNA damage and apoptosis, or inhibit cell clone formation.	Curcumin	292-300	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	182-190
32515250-7	2020	Curcumin suppressed irradiation-induced NF-kappaB activation by suppressing IKKgamma expression, but not IKKalpha and IKKbeta.	Curcumin	0-8	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	76-84
32515250-11	2020	Additionally, IKKgamma silencing inhibited expression of Bcl-XL, Bcl-2, and cyclin D1.Conclusions: Curcumin enhances LSCC radiosensitivity via NF-KappaB inhibition by suppressing IKKgamma expression.	Curcumin	99-107	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	14-22
32515250-11	2020	Additionally, IKKgamma silencing inhibited expression of Bcl-XL, Bcl-2, and cyclin D1.Conclusions: Curcumin enhances LSCC radiosensitivity via NF-KappaB inhibition by suppressing IKKgamma expression.	Curcumin	99-107	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	179-187
31854220-5	2020	The expression of MAPK, NF-kappaB, MMP9, MMP2 and vimentin were confirmed by RT-PCR, immunohistochemistry or western blotting.Results: Administration of curcumin significantly inhibited tumour growth, as the tumour weight decreased from 0.67 g (control) to 0.47 g (15 mg/kg) and 0.35 g (30 mg/kg).	Curcumin	153-161	vimentin	Homo sapiens	50-58
31854220-6	2020	Curcumin inhibited the expression of PCNA and increased the degree of TUNEL and cleaved caspase-3 staining in tumour tissue.	Curcumin	0-8	proliferating cell nuclear antigen	Homo sapiens	37-41
31854220-9	2020	Curcumin also suppressed the level of vimentin.Discussion and conclusions: Our study demonstrates that curcumin can inhibit the growth and invasion of human monocytic leukaemia in vivo, suggesting the possible use of curcumin for anti-metastasis in leukaemia and the value of determining its unique target.	Curcumin	0-8	vimentin	Homo sapiens	38-46
31854220-9	2020	Curcumin also suppressed the level of vimentin.Discussion and conclusions: Our study demonstrates that curcumin can inhibit the growth and invasion of human monocytic leukaemia in vivo, suggesting the possible use of curcumin for anti-metastasis in leukaemia and the value of determining its unique target.	Curcumin	103-111	vimentin	Homo sapiens	38-46
31854220-9	2020	Curcumin also suppressed the level of vimentin.Discussion and conclusions: Our study demonstrates that curcumin can inhibit the growth and invasion of human monocytic leukaemia in vivo, suggesting the possible use of curcumin for anti-metastasis in leukaemia and the value of determining its unique target.	Curcumin	217-225	vimentin	Homo sapiens	38-46
32468514-0	2020	Interplay of curcumin and its liver metabolism on the level of Abeta in the brain of APPswe/PS1dE9 mice before AD onset.	Curcumin	13-21	amyloid beta (A4) precursor protein	Mus musculus	63-68
32468514-3	2020	METHODS: Curcumin was administered to 5-month-old APP/PS1 transgenic mice for 7 consecutive days using the intragastric (ig) and intracerebroventricular (icv) administration routes, respectively.	Curcumin	9-17	presenilin 1	Mus musculus	54-57
32468514-6	2020	RESULTS: In the ig group, curcumin ameliorated anxiety-like behavior and suppressed the level of Abeta42 in the liver and the total Abeta in the brain.	Curcumin	26-34	amyloid beta (A4) precursor protein	Mus musculus	97-102
32468514-7	2020	In the icv group, curcumin treatment affected the distribution of Abeta42 and IL-1beta in the brain compared to the liver.	Curcumin	18-26	interleukin 1 alpha	Mus musculus	78-86
32866059-9	2020	Moreover, curcumin reduced the levels of IL-6, IL-1beta and TNF-alpha by 22.5%, 30.3% and 26.7%, respectively, and suppressed vimentin expression in UUO mice.	Curcumin	10-18	interleukin 1 alpha	Mus musculus	47-55
32866059-11	2020	In LPS-induced HK-2 cells, curcumin decreased the release of IL-6, IL-1beta and TNF-alpha by 43.4%, 38.1% and 28.3%, respectively.	Curcumin	27-35	interleukin 1 alpha	Mus musculus	67-75
33248620-0	2020	Curcumin ameliorates duodenal toxicity of AFB1 in chicken through inducing P-glycoprotein and downregulating cytochrome P450 enzymes.	Curcumin	0-8	phosphoglycolate phosphatase	Gallus gallus	75-89
33248620-9	2020	Furthermore, curcumin ameliorated AFB1-induced decrease in the Abcb1 mRNA expression, P-glycoprotein (P-gp) level, and ATPase activities.	Curcumin	13-21	phosphoglycolate phosphatase	Gallus gallus	86-100
33248620-9	2020	Furthermore, curcumin ameliorated AFB1-induced decrease in the Abcb1 mRNA expression, P-glycoprotein (P-gp) level, and ATPase activities.	Curcumin	13-21	phosphoglycolate phosphatase	Gallus gallus	102-106
33248620-10	2020	It has been suggested from these results that curcumin supplementation in the feed could ameliorate AFB1-induced duodenal toxicity and damage through downregulating CYP450 enzymes, promoting ATPase activities, and inducing P-gp in chickens.	Curcumin	46-54	phosphoglycolate phosphatase	Gallus gallus	223-227
32761362-7	2020	Curcumin increased expression levels of the pro-survival B cell lymphoma extra-large (Bcl-xL) gene and two genes involved in mitochondrial function, peroxisome proliferative-activated receptor-gamma co-activator 1alpha (PGC-1alpha) and mitochondrial transcription factor A (TFAM), in the hippocampus of BDL rats compared with the vehicle-treated sham or BDL rats, while it decreased the pro-apoptotic Bcl-2-associated X protein (Bax) gene expression level.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	401-427
32761362-7	2020	Curcumin increased expression levels of the pro-survival B cell lymphoma extra-large (Bcl-xL) gene and two genes involved in mitochondrial function, peroxisome proliferative-activated receptor-gamma co-activator 1alpha (PGC-1alpha) and mitochondrial transcription factor A (TFAM), in the hippocampus of BDL rats compared with the vehicle-treated sham or BDL rats, while it decreased the pro-apoptotic Bcl-2-associated X protein (Bax) gene expression level.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	429-432
32761362-9	2020	Furthermore, curcumin reduced the mRNA level of Bax, while it increased Bcl-2 and TFAM mRNA levels.	Curcumin	13-21	BCL2 associated X, apoptosis regulator	Rattus norvegicus	48-51
32912630-4	2020	Using a fluorinated-derivative of curcumin (designated Shiga-Y6), we showed significant inhibition of TXNIP mRNA and protein expression, and induction of TRX mRNA and protein in ARPE-19 retinal pigment epithelial cells and THP-1-derived macrophages, while the non-fluorinated structural equivalent (Shiga-Y52) and native curcumin did not show these same effects.	Curcumin	34-42	thioredoxin	Homo sapiens	154-157
33217990-6	2020	Curcumin quenches free radicals, induces antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase), and upregulates antioxidative protein markers-Nrf2 and HO-1 that lead to the suppression of cellular oxidative stress.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	174-178
32738342-5	2020	The present researches aimed to investigate the effect of curcumin on MAT2B expression in HSCs in vivo and in vitro.	Curcumin	58-66	methionine adenosyltransferase II, beta	Mus musculus	70-75
32738342-6	2020	Results demonstrated that curcumin could reduce MAT2B expression in HSCs at multiple levels.	Curcumin	26-34	methionine adenosyltransferase II, beta	Mus musculus	48-53
32738342-8	2020	The effect of curcumin on MAT2B was through its interruption of p38 MAPK signaling pathway.	Curcumin	14-22	methionine adenosyltransferase II, beta	Mus musculus	26-31
32738342-10	2020	Curcumin down-regulation of MAT2B contributed to the inhibitory role of curcumin on HSC activation and collagen expression in mouse livers.	Curcumin	0-8	methionine adenosyltransferase II, beta	Mus musculus	28-33
32738342-10	2020	Curcumin down-regulation of MAT2B contributed to the inhibitory role of curcumin on HSC activation and collagen expression in mouse livers.	Curcumin	72-80	methionine adenosyltransferase II, beta	Mus musculus	28-33
32738342-11	2020	This study provided evidences for the effect of curcumin on the expression of MAT2B, an enzyme for the biosynthesis of methyl donor S-adenosylmethionine, in HSCs and demonstrated the function significance of curcumin-induced downregulation of MAT2B in curcumin inhibition of liver fibrosis.	Curcumin	48-56	methionine adenosyltransferase II, beta	Mus musculus	78-83
33155879-8	2021	The actions of curcumin are achieved by several mechanisms, such as reducing the expression of interleukin (IL)-1, IL-6, IL-12, and tumor necrosis factor-alpha.	Curcumin	15-23	interleukin 1 alpha	Homo sapiens	95-113
33204708-14	2020	In addition, curcumin downregulated the expression of Bax, Caspase-3, p62, PI3K, p-AKT, and p-mTOR proteins and upregulated the Bcl-2, beclin1, LC3, Nrf2, and HO-1 levels in this animal model.	Curcumin	13-21	BCL2 associated X, apoptosis regulator	Rattus norvegicus	54-57
32934683-6	2020	Combined rAd-p53 and curcumin treatment resulted in higher p53 (P<0.01) and p21 (P<0.01) expression compared with rAd-p53 or curcumin were added alone, suggesting an additive effect on TP53 expression.	Curcumin	21-29	H3 histone pseudogene 16	Homo sapiens	76-79
33281265-0	2020	Combination of Silibinin and Curcumin Reduced Leptin Receptor Expression in MCF-7 Human Breast Cancer Cell Line.	Curcumin	29-37	leptin	Homo sapiens	46-52
33281265-2	2020	We investigated the cytotoxic effect of silibinin and curcumin, individually and combined, on Ob-R expression in MCF-7 cells.	Curcumin	54-62	leptin receptor	Homo sapiens	94-98
33281265-6	2020	The expression of Ob-R was measured using the Western blot analysis by treating the cells with different concentrations of curcumin (10-25 muM), silibinin (50-250 muM), and their respective combinations.	Curcumin	123-131	leptin receptor	Homo sapiens	18-22
33281265-13	2020	Conclusion: The combination of silibinin and curcumin significantly reduced Ob-R expression in MCF-7 cells compared with their individual effects.	Curcumin	45-53	leptin receptor	Homo sapiens	76-80
31983246-10	2020	Tq + Cur treatment increased the expressions of phosphorylated Akt, Nrf2 and HO-1 proteins while decreasing the levels of cleaved caspase 3 and NFkB in kidney homogenates.	Curcumin	5-8	heme oxygenase 1	Homo sapiens	77-81
31983246-11	2020	In summary, Tq + Cur had protective effects on cisplatin-induced nephrotoxicity and renal injury, which could be mediated by up-regulation of survival signals like Akt, Nrf2/HO-1, and attenuation of KIM-1, NFkB.	Curcumin	17-20	heme oxygenase 1	Homo sapiens	174-178
32735936-4	2020	Curcumin enhanced the expression of c-Jun and c-Fos, which are functional subunits of AP-1, in the nuclear fraction of cells.	Curcumin	0-8	FBJ osteosarcoma oncogene	Mus musculus	46-51
32735936-7	2020	Curcumin increased phosphorylation of ERK1/2 and JNK, and pharmacologic inhibition of these kinases abrogated the curcumin-induced phosphorylation of c-Jun and 15-PGDH expression.	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	49-52
32735936-7	2020	Curcumin increased phosphorylation of ERK1/2 and JNK, and pharmacologic inhibition of these kinases abrogated the curcumin-induced phosphorylation of c-Jun and 15-PGDH expression.	Curcumin	114-122	mitogen-activated protein kinase 8	Rattus norvegicus	49-52
32891672-6	2020	Contrarily, after inhibiting Ca2+ influx with EGTA, riluzole alone and in combination with curcumin significantly downregulated hypoxia-induced expression of GFAP and NF-H.	Curcumin	91-99	neurofilament heavy chain	Homo sapiens	167-171
32891672-7	2020	After analysis of caspase 9 and cleaved caspase 9, we observed that curcumin and riluzole both inhibit apoptosis significantly, whereas their combination remains ineffective.	Curcumin	68-76	caspase 9	Homo sapiens	18-27
32891672-7	2020	After analysis of caspase 9 and cleaved caspase 9, we observed that curcumin and riluzole both inhibit apoptosis significantly, whereas their combination remains ineffective.	Curcumin	68-76	caspase 9	Homo sapiens	40-49
32891672-8	2020	Furthermore, we observed that neuroprotective effects of curcumin and riluzole are mediated through Nrf2/HO-1 signaling.	Curcumin	57-65	heme oxygenase 1	Homo sapiens	105-109
32963615-4	2020	In addition, curcumin (CMN) enhances antitumor effects in NSCLC by downregulating ERCC1.	Curcumin	13-21	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	82-87
32963615-4	2020	In addition, curcumin (CMN) enhances antitumor effects in NSCLC by downregulating ERCC1.	Curcumin	23-26	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	82-87
33142463-5	2020	Besides, the expression level of IL-1beta mRNA showed significant increase during dihydromyricetin, chlorogenic acid, naringin, imiquimod, thymopentin, beta-D-Glucan, astragalus polysacharin, astragalus saponin I, astragalus flavone, curcumin, CpG-DNA-2, and LPS treatment.	Curcumin	234-242	interleukin 1 alpha	Homo sapiens	33-41
32338107-12	2020	We verified the direct regulation of PTEN by miR-181a in cultured human embryonic kidney 293T cells.Conclusions: We showed the involvement of miR-181a/PTEN axis in the renoprotective effect of curcumin against cisplatin-induced AKI, and provide new evidence on the ability of curcumin to alleviate cisplatin-induced nephrotoxicity.	Curcumin	276-284	phosphatase and tensin homolog	Homo sapiens	37-41
32338107-12	2020	We verified the direct regulation of PTEN by miR-181a in cultured human embryonic kidney 293T cells.Conclusions: We showed the involvement of miR-181a/PTEN axis in the renoprotective effect of curcumin against cisplatin-induced AKI, and provide new evidence on the ability of curcumin to alleviate cisplatin-induced nephrotoxicity.	Curcumin	276-284	phosphatase and tensin homolog	Homo sapiens	151-155
33103592-4	2022	The main objective of this work is to evaluate the binding of curcumin and its metabolites with the active sites of collagenases in comparison to standard inhibitors on the basis of our hypothesis that curcumin/metabolites could exhibit an inhibitory effect on MMPs.	Curcumin	62-70	matrix metallopeptidase 1	Homo sapiens	261-265
33103592-4	2022	The main objective of this work is to evaluate the binding of curcumin and its metabolites with the active sites of collagenases in comparison to standard inhibitors on the basis of our hypothesis that curcumin/metabolites could exhibit an inhibitory effect on MMPs.	Curcumin	202-210	matrix metallopeptidase 1	Homo sapiens	261-265
33103592-5	2022	Here, we report the molecular docking analysis of curcumin and its metabolites with collagenases (MMP-1, MMP-8, MMP-13).	Curcumin	50-58	matrix metallopeptidase 1	Homo sapiens	98-103
33103592-5	2022	Here, we report the molecular docking analysis of curcumin and its metabolites with collagenases (MMP-1, MMP-8, MMP-13).	Curcumin	50-58	matrix metallopeptidase 8	Homo sapiens	105-110
33178666-2	2020	Antiaging, anti-inflammatory, antioxidant, antitumor, chemosensitizing, P-gp efflux inhibiting, and antiproliferative activity are some of the striking features of curcumin, highlighting its importance in chemotherapy.	Curcumin	164-172	phosphoglycolate phosphatase	Homo sapiens	72-76
33178666-3	2020	Curcumin inhibits Bcl-2, Bcl-XL, VEGF, c-Myc, ICAM-1, EGFR, STAT3 phosphorylation, and cyclin D1 genes involved in the various stages of breast, prostate, and gastric cancer proliferation, angiogenesis, invasion, and metastasis.	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	39-44
32822714-0	2020	Effect of Atorvastatin, Curcumin, and Quercetin on miR-21 and miR-122 and their correlation with TGFbeta1 expression in experimental liver fibrosis.	Curcumin	24-32	microRNA 122	Rattus norvegicus	62-69
32822714-4	2020	In the present study, we investigate the effects of curcumin, quercetin, and atorvastatin on the expression levels of miR-21 and miR-122 and evaluated their correlation with TGFbeta1 expression in bile duct ligation (BDL)-induced fibrotic rats.	Curcumin	52-60	microRNA 122	Rattus norvegicus	129-136
33163337-5	2020	During the last decade, several products, including naturally occurring dietary agents as well as a wide variety of products from plant sources, including curcumin, quercetin, berberin, and ginsenosides, have been identified as potent modulators of the Wnt/beta-catenin signaling and have gained interest as promising candidates for the development of chemopreventive or therapeutic drugs for cancer.	Curcumin	155-163	catenin beta 1	Homo sapiens	257-269
32535666-9	2020	In vitro, CD4+CD25+FOXP3+ Treg cells from naive CD4+ T cells, STAT5 proportion, and IL-35 expression increased after curcumin treatment.	Curcumin	117-125	forkhead box P3	Mus musculus	19-24
32535666-9	2020	In vitro, CD4+CD25+FOXP3+ Treg cells from naive CD4+ T cells, STAT5 proportion, and IL-35 expression increased after curcumin treatment.	Curcumin	117-125	signal transducer and activator of transcription 5A	Mus musculus	62-67
32814232-8	2020	RESULTS: We found that punicalagin and curcumin significantly supressed TNF-induced pro-inflammatory cytokine (IL1A, IL1B, and IL6) and chemokine (CCL2-4, CXCL1, CXCL5 and CXCL8) expression in human placenta, VAT and SAT.	Curcumin	39-47	interleukin 1 alpha	Homo sapiens	111-115
32814232-8	2020	RESULTS: We found that punicalagin and curcumin significantly supressed TNF-induced pro-inflammatory cytokine (IL1A, IL1B, and IL6) and chemokine (CCL2-4, CXCL1, CXCL5 and CXCL8) expression in human placenta, VAT and SAT.	Curcumin	39-47	C-C motif chemokine ligand 24	Homo sapiens	147-153
32718261-5	2020	The results indicated that PE and/or curcumin attenuated TAA-induced liver fibrogenesis, as evidenced by significant improvement in the liver function tests (AST, ALT, ALP, and albumin), oxidative stress biomarkers (MDA, SOD, and GSH), and inflammatory biomarkers (NF-kB, TNF-alpha, IL-1beta, iNOS, TGF-beta, and MPO), compared to TAA group.	Curcumin	37-45	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	265-270
33062432-1	2020	Previously, we reported the synergistic effects of curcumin and piperine in cell cultures as potential anti-cholinesterase and anti-amyloidogenic agents.	Curcumin	51-59	butyrylcholinesterase	Homo sapiens	108-122
33046993-8	2020	Our results showed that curcumin induced ROS accumulation, apoptosis, autophagy, cell cycle arrest, and cellular senescence accompanied by upregulation of p53 and p21 proteins in SiHa cells.	Curcumin	24-32	H3 histone pseudogene 16	Homo sapiens	163-166
33029254-10	2020	The inhibitory effect of curcumin on the Abeta level was significant in the cerebrum (P < 0.001) and retina (P < 0.01) of older APP mice in the early stage of life.	Curcumin	25-33	amyloid beta (A4) precursor protein	Mus musculus	41-46
33029254-13	2020	Although curcumin can label Abeta in the retina, it also suppresses Abeta levels and weakens the degree of correlation between Abeta in cerebrum and retina tissues.	Curcumin	9-17	amyloid beta (A4) precursor protein	Mus musculus	28-33
33029254-13	2020	Although curcumin can label Abeta in the retina, it also suppresses Abeta levels and weakens the degree of correlation between Abeta in cerebrum and retina tissues.	Curcumin	9-17	amyloid beta (A4) precursor protein	Mus musculus	68-73
33029254-13	2020	Although curcumin can label Abeta in the retina, it also suppresses Abeta levels and weakens the degree of correlation between Abeta in cerebrum and retina tissues.	Curcumin	9-17	amyloid beta (A4) precursor protein	Mus musculus	68-73
33005455-8	2020	Turmeric/curcumin may stimulate iron uptake through a decrease in hepcidin expression and inhibit uptake by complex formation with iron, but the net effect has not been clarified.	Curcumin	9-17	hepcidin antimicrobial peptide	Homo sapiens	66-74
32876538-2	2022	This study demonstrated the putative inhibitory potential of curcumin, allicin, and gingerol towards cathepsin K, COVID-19 main protease, and SARS-CoV 3 C-like protease.	Curcumin	61-69	cathepsin K	Homo sapiens	101-112
32876538-6	2022	Moreover, it was observed that curcumin exhibited the highest binding free energy of -17.90 +- 0.23,  -18.21 +- 0.25, and -9.67 +- 0.08 kcal/mol for Cathepsin K, COVID-19 main protease, and SARS-CoV 3 C-like protease, respectively.	Curcumin	31-39	cathepsin K	Homo sapiens	149-160
32776418-0	2020	Curcumin reinforces MSC-derived exosomes in attenuating osteoarthritis via modulating the miR-124/NF-kB and miR-143/ROCK1/TLR9 signalling pathways.	Curcumin	0-8	microRNA 143	Mus musculus	108-115
32776418-4	2020	Additionally, quantitative real-time PCR and Western blot assays showed that the exosomes derived from curcumin-treated MSCs significantly restored the down-regulated miR-143 and miR-124 expression as well as up-regulated NF-kB and ROCK1 expression in OA cells.	Curcumin	103-111	microRNA 143	Mus musculus	167-174
32776418-5	2020	Mechanistically, curcumin treatment decreased the DNA methylation of miR-143 and miR-124 promoters.	Curcumin	17-25	microRNA 143	Mus musculus	69-76
32526690-7	2020	Curcumin inhibits levels of reactive oxygen species (ROS) and oxidative stress in hepatocytes by activating PPAR-alpha, and regulates upstream signaling pathways of autophagy AMPK and PI3K/AKT/mTOR, leading to an increase of the autophagic flow in hepatocytes.	Curcumin	0-8	peroxisome proliferator activated receptor alpha	Homo sapiens	108-118
32445778-0	2020	Curcumin suppress glioblastoma cell proliferation by p-AKT/mTOR pathway and increased the PTEN expression.	Curcumin	0-8	phosphatase and tensin homolog	Homo sapiens	90-94
32445778-9	2020	Further, we found that curcumin promoted the PTEN and p53 expression, as the tumor suppressor genes.	Curcumin	23-31	phosphatase and tensin homolog	Homo sapiens	45-49
32757174-0	2021	LncRNA KCNQ1OT1 is a key factor in the reversal effect of curcumin on cisplatin resistance in the colorectal cancer cells.	Curcumin	58-66	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	7-15
32502496-0	2020	The pivotal role of SUMO-1-JNK-Tau axis in an in vitro model of oxidative stress counteracted by the protective effect of curcumin.	Curcumin	122-130	microtubule associated protein tau	Homo sapiens	31-34
32502496-5	2020	Curcumin, a natural compound with anti-oxidant and anti-inflammatory effects, demonstrated to tackle oxidative stress re-equilibrating SUMO-1, JNK and Tau functions.	Curcumin	0-8	microtubule associated protein tau	Homo sapiens	151-154
32502496-8	2020	These results highlight the SUMO-1-JNK-Tau axis key role in oxidative stress and the protective effect of curcumin against this pathological event, focusing on the importance of SUMO/deSUMOylation balance to regulate essential cellular processes.	Curcumin	106-114	microtubule associated protein tau	Homo sapiens	39-42
32563890-0	2020	Synthesis of new curcumin derivatives as influential antidiabetic alpha-glucosidase and alpha-amylase inhibitors with anti-oxidant activity.	Curcumin	17-25	sucrase-isomaltase	Homo sapiens	66-83
32615888-0	2020	Curcumin attenuates inflammation and cell apoptosis through regulating NF-kappaB and JAK2/STAT3 signaling pathway against acute kidney injury.	Curcumin	0-8	Janus kinase 2	Mus musculus	85-89
32223496-0	2020	Curcumin analogs as the inhibitors of TLR4 pathway in inflammation and their drug like potentialities: a computer-based study.	Curcumin	0-8	toll like receptor 4	Homo sapiens	38-42
32223496-3	2020	In this study, Curcumin and its different analogs have been analyzed as the inhibitors of signaling proteins, i.e. Cycloxygenase-2 (COX-2), inhibitor of kappabeta kinase (IKK) and TANK binding kinase-1 (TBK-1) of TLR4 pathway using different computational tools.	Curcumin	15-23	TANK binding kinase 1	Homo sapiens	180-201
31972207-8	2020	Additionally, curcumin reduced the LPS-induced increase in Bax, cleaved-caspase3/caspase 3, p-IkBalpha/IkBalpha, p-p65/p65, p-JNK/JNK, and p-c-JUN/c-JUN protein expression, and increased Bcl2 protein expression in NRK cells.	Curcumin	14-22	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	115-118
32554101-7	2020	Administration of curcumin or curcumol significantly diminished the level of hydroxyproline hydroxyproline and alpha-smooth muscle actin (alpha-SMA), also the collagen I (Col-I) and collagen III (Col-III) deposition were reduced in the HLF.	Curcumin	18-26	HLF transcription factor, PAR bZIP family member	Homo sapiens	236-239
32718217-8	2020	When the periodontitis groups were compared, curcumin treatment resulted in lower IL-1beta (Group 2 median: 0.002, Group 1 median: 0.12) and IL-6 (Group 2 median: 0.031, Group 1 median: 0.078) and higher IL-17 (Group 2 median: 1.07, Group 1 median: 0.583) relative mRNA expression in Group 2 than in Group 1 (p < 0.001).	Curcumin	45-53	interleukin 17A	Rattus norvegicus	204-209
32703287-0	2020	Curcumin inhibits the migration of osteoclast precursors and osteoclastogenesis by repressing CCL3 production.	Curcumin	0-8	chemokine (C-C motif) ligand 3	Mus musculus	94-98
32703287-4	2020	METHODS: In this study, we investigated the role of curcumin in regulating the production of several chemokines (CCL2, CCL3 and CX3CL1) and the migration of OCPs by ELISA, Western blotting and Transwell assays.	Curcumin	52-60	chemokine (C-C motif) ligand 3	Mus musculus	119-123
32703287-6	2020	RESULTS: The results showed that curcumin significantly reduced the production of CCL3 in OCPs.	Curcumin	33-41	chemokine (C-C motif) ligand 3	Mus musculus	82-86
32703287-8	2020	Remarkably, curcumin-reduced osteoclastogenesis was significantly reversed by CCL3 addition, while CCR1 overexpression did not increase the osteoclastogenesis in the presence of curcumin.	Curcumin	12-20	chemokine (C-C motif) ligand 3	Mus musculus	78-82
32703287-9	2020	Furthermore, in vivo assays also showed that curcumin significantly reduced the production of CCL3 in OCPs in the trabecular bone of OVX mice.	Curcumin	45-53	chemokine (C-C motif) ligand 3	Mus musculus	94-98
32703287-10	2020	CONCLUSIONS: In conclusion, curcumin prevents the migration of OCPs by reducing CCL3 production, ultimately inhibiting the formation of mature osteoclasts.	Curcumin	28-36	chemokine (C-C motif) ligand 3	Mus musculus	80-84
32403017-2	2020	The natural product curcumin is known to provide an efficient scaffold for compounds capable of blocking Pgp mediated efflux and sensitization of multidrug resistant (MDR) cells to the Pgp transported drug doxorubicin (Dox).	Curcumin	20-28	phosphoglycolate phosphatase	Homo sapiens	105-108
32403017-2	2020	The natural product curcumin is known to provide an efficient scaffold for compounds capable of blocking Pgp mediated efflux and sensitization of multidrug resistant (MDR) cells to the Pgp transported drug doxorubicin (Dox).	Curcumin	20-28	phosphoglycolate phosphatase	Homo sapiens	185-188
32403017-3	2020	We performed molecular dynamics simulations and docking of curcumin derivatives into the Pgp model.	Curcumin	59-67	phosphoglycolate phosphatase	Homo sapiens	89-92
32403017-7	2020	Together with good water solubility of 16 and 19, these results indicate that the new pyrazolo derivatives of curcumin are a promising scaffold for development of clinically applicable Pgp antagonists.	Curcumin	110-118	phosphoglycolate phosphatase	Homo sapiens	185-188
32719582-4	2020	Using curcumin, a FluoroProbe that binds to Abeta, we labeled and measured the retinal fluorescence in vivo and compared with the immunohistochemical measurements of the brain and retinal Abeta load in the APP/PS1 mouse model.	Curcumin	6-14	amyloid beta (A4) precursor protein	Mus musculus	44-49
32719582-12	2020	Finally, and most importantly, the correlation between in vivo retinal fluorescence with curcumin injection and Abeta immunoreactivity in the cortex was stronger in Tg compared to WT groups.	Curcumin	89-97	amyloid beta (A4) precursor protein	Mus musculus	112-117
32719582-14	2020	In vivo retinal fluorescence with curcumin correlated strongly with cortical Abeta immunohistochemistry in Tg mice.	Curcumin	34-42	amyloid beta (A4) precursor protein	Mus musculus	77-82
32744672-0	2020	Over-expression of DJ-1 attenuates effects of curcumin on colorectal cancer cell proliferation and apoptosis.	Curcumin	46-54	Parkinsonism associated deglycase	Homo sapiens	19-23
32802291-0	2020	The Effect of Low-Level Laser Therapy and Curcumin on the Expression of LC3, ATG10 and BAX/BCL2 Ratio in PC12 Cells Induced by 6-Hydroxide Dopamine.	Curcumin	42-50	BCL2 associated X, apoptosis regulator	Rattus norvegicus	87-90
32802291-6	2020	The effects of CU and LLLT on Bax/Bcl2 and LC3/ATG10 expression were analyzed by real-time PCR and cell viability was assessed by MTT assay.	Curcumin	15-17	BCL2 associated X, apoptosis regulator	Rattus norvegicus	30-33
32572733-0	2020	Curcumin attenuates IL-17A mediated pulmonary SMAD dependent and non-dependent mechanism during acute lung injury in vivo.	Curcumin	0-8	SMAD family member 6	Mus musculus	46-50
22139626-1	2011	The aim of the present study was to investigate the effect of curcumin (Cur) on the activity of ectonucleoside triphosphate diphosphohydrolase (CD39), 5"-nucleotidase (CD73) and adenosine deaminase in platelets of cigarette smoke-exposed rats.	Curcumin	62-70	5' nucleotidase, ecto	Rattus norvegicus	168-172
32572733-8	2020	Increase phosphorylation of non- SMAD proteins like P-EGFR, P-STAT-1, STAT-3, P-JAK-1/2, P-JNK, and also SMAD proteins like P- SMAD 2/3 and TGF-beta1 was encountered upon IL-17A exposure, while curcumin intervention reversed the protein expression levels.	Curcumin	194-202	SMAD family member 6	Mus musculus	33-37
22113199-8	2011	Notably, disruption of Sp1 sites by point mutagenesis abolished curcumin transactivation of Prdx6.	Curcumin	64-72	peroxiredoxin 6	Homo sapiens	92-97
32572733-8	2020	Increase phosphorylation of non- SMAD proteins like P-EGFR, P-STAT-1, STAT-3, P-JAK-1/2, P-JNK, and also SMAD proteins like P- SMAD 2/3 and TGF-beta1 was encountered upon IL-17A exposure, while curcumin intervention reversed the protein expression levels.	Curcumin	194-202	SMAD family member 6	Mus musculus	105-109
32572733-9	2020	Curcumin was found to block mRNA expressions of non- SMAD genes EGFR, JNK-1, JAK1, JAK2, STAT-1, STAT-3, MAPK14, also of TGF-beta1 and SMAD genes like SMAD 2, SMAD 3.	Curcumin	0-8	SMAD family member 6	Mus musculus	53-57
32572733-9	2020	Curcumin was found to block mRNA expressions of non- SMAD genes EGFR, JNK-1, JAK1, JAK2, STAT-1, STAT-3, MAPK14, also of TGF-beta1 and SMAD genes like SMAD 2, SMAD 3.	Curcumin	0-8	epidermal growth factor receptor	Mus musculus	64-68
22113199-9	2011	Also, curcumin failed to activate Prdx6 expression in the presence of Sp1 inhibitors, demonstrating that curcumin-mediated increased expression of Prdx6 was dependent on Sp1 activity.	Curcumin	105-113	peroxiredoxin 6	Homo sapiens	147-152
32572733-9	2020	Curcumin was found to block mRNA expressions of non- SMAD genes EGFR, JNK-1, JAK1, JAK2, STAT-1, STAT-3, MAPK14, also of TGF-beta1 and SMAD genes like SMAD 2, SMAD 3.	Curcumin	0-8	Janus kinase 2	Mus musculus	83-87
32572733-9	2020	Curcumin was found to block mRNA expressions of non- SMAD genes EGFR, JNK-1, JAK1, JAK2, STAT-1, STAT-3, MAPK14, also of TGF-beta1 and SMAD genes like SMAD 2, SMAD 3.	Curcumin	0-8	SMAD family member 6	Mus musculus	135-139
32572733-10	2020	However, mRNA expressions of SMAD 6 and SMAD 7 were increased upon curcumin intervention.	Curcumin	67-75	SMAD family member 6	Mus musculus	29-35
21889563-6	2011	Treatment with free curcumin showed &lt;= 15% recovery in membrane lipids (LPO) and 22% recovery in acetylcholinesterase (AChE) with respect to AlCl(3) treated group.	Curcumin	20-28	acetylcholinesterase	Mus musculus	100-120
32585875-1	2020	We hypothesized that treatment with pharmacological agents known to increase sirtuin-1 activity (resveratrol and curcumin) may enhance muscle regeneration.	Curcumin	113-121	sirtuin 1	Mus musculus	77-86
32585875-4	2020	Treatment with either resveratrol or curcumin in reloaded muscles compared to non-treated mice induced a significant improvement in the CSA of both hybrid (curcumin) and fast-twitch fibers (resveratrol), sirtuin-1 activity (curcumin), sirtuin-1 content (resveratrol), and counts of progenitor muscle cells (resveratrol).	Curcumin	37-45	sirtuin 1	Mus musculus	204-213
32585875-4	2020	Treatment with either resveratrol or curcumin in reloaded muscles compared to non-treated mice induced a significant improvement in the CSA of both hybrid (curcumin) and fast-twitch fibers (resveratrol), sirtuin-1 activity (curcumin), sirtuin-1 content (resveratrol), and counts of progenitor muscle cells (resveratrol).	Curcumin	37-45	sirtuin 1	Mus musculus	235-244
32472767-0	2020	Curcumin inhibits high glucose oxidative stress and apoptosis in pancreatic beta cells via CHOP/PCG-1a  and pERK1/2.	Curcumin	0-8	DNA-damage inducible transcript 3	Mus musculus	91-95
32472767-3	2020	Moreover, curcumin prevents HG induced increase in expression of CHOP, decrease in PCG-1a and phosphorylation of ERK1/2 (pERK1/2) without any effect on the phosphorylation levels of p38 and JNK.	Curcumin	10-18	DNA-damage inducible transcript 3	Mus musculus	65-69
32472767-5	2020	Overexpression of CHOP or siRNA knockdown of PCG-1a counteracted the effect of curcumin on HG induced apoptosis and oxidative stress.	Curcumin	79-87	DNA-damage inducible transcript 3	Mus musculus	18-22
32472767-6	2020	These results suggest that curcumin acts through CHOP/PCG-1a and ERK1/2 signaling to block the HG induced oxidative stress and apoptosis.	Curcumin	27-35	DNA-damage inducible transcript 3	Mus musculus	49-53
32215945-7	2020	The results showed that estimations of IL-10 concentrations were significantly increased in curcumin groups compared with CCl4 group, whereas TNF-alpha and TGF-1beta levels were significantly decreased comparing with CCl4 group.	Curcumin	92-100	interleukin 10	Rattus norvegicus	39-44
32472295-4	2020	Meanwhile, curcumin decreased the level of cleaved caspase-3 and the release of TNF-alpha, IL-1beta, IL-6, but increased IL-10 release in LPS-treated BV2 cells.	Curcumin	11-19	interleukin 1 alpha	Mus musculus	91-99
32472295-9	2020	Furthermore, curcumin suppressed p-p65 expression via regulating miR-362-3p/TLR4 axis.	Curcumin	13-21	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	35-38
32278045-11	2020	Moreover, evidence revealed that curcumin downregulates the E3-ubiquitin ligases NEDD4, neural precursor cell-expressed developmentally downregulated 4.	Curcumin	33-41	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	81-86
32278045-13	2020	Finally another suggested mechanism is suppression of MAOA/mTORC1/hypoxia-inducible factor 1alpha signaling pathway by curcumin.	Curcumin	119-127	monoamine oxidase A	Homo sapiens	54-58
32547215-0	2020	Curcumin Affects Gastric Cancer Cell Migration, Invasion and Cytoskeletal Remodeling Through Gli1-beta-Catenin.	Curcumin	0-8	catenin beta 1	Homo sapiens	98-110
32547215-2	2020	The present study aimed to observe the effects of curcumin on gastric cancer cells through the Shh and Wnt signaling pathways.	Curcumin	50-58	sonic hedgehog signaling molecule	Homo sapiens	95-98
32547215-5	2020	Results: We show that curcumin suppressed the expression of Shh, Gli1 and Foxm1 in the Shh signaling pathway, and the expression of beta-catenin in the Wnt signaling pathway in SGC-7901 cells, both in mRNA and protein.	Curcumin	22-30	sonic hedgehog signaling molecule	Homo sapiens	60-63
32547215-5	2020	Results: We show that curcumin suppressed the expression of Shh, Gli1 and Foxm1 in the Shh signaling pathway, and the expression of beta-catenin in the Wnt signaling pathway in SGC-7901 cells, both in mRNA and protein.	Curcumin	22-30	sonic hedgehog signaling molecule	Homo sapiens	87-90
32547215-10	2020	Furthermore, a physical interaction was observed between Gli1 of the Shh signaling and beta-catenin of the Wnt signaling in these cells, but curcumin inhibited the interaction of these two proteins.	Curcumin	141-149	sonic hedgehog signaling molecule	Homo sapiens	69-72
32547215-11	2020	Conclusion: The present study indicated that curcumin plays an anti-tumor role through Gli1-beta-catenin pathway in gastric cancer SGC-7901 cells.	Curcumin	45-53	catenin beta 1	Homo sapiens	92-104
32375323-9	2020	Furthermore, OLETF rats exercised and fed curcumin had lower IL6, TNFalpha, and IL10 levels (indicators of inflammatory response) and lower levels of ER stress markers (BiP and CHOP) in the intestine than OLETF controls.	Curcumin	42-50	DNA-damage inducible transcript 3	Rattus norvegicus	177-181
32222339-4	2020	Herein we report a series of compounds by molecular hybridization PARP-1 inhibitor Olaparib (Ola) with HSP90 inhibitor C0817 (one curcumin derivative).	Curcumin	130-138	heat shock protein 90 alpha family class A member 1	Homo sapiens	103-108
32124251-4	2020	Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment.	Curcumin	0-8	inositol-3-phosphate synthase 1	Homo sapiens	80-84
32124251-4	2020	Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment.	Curcumin	0-8	matrix metallopeptidase 1	Homo sapiens	136-141
32124251-4	2020	Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment.	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	276-284
32124251-5	2020	Curcumin treatment also decreased oxidative stress injury following IL-1beta stimulation.	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	68-76
32124251-6	2020	Pathway analysis demonstrated that the ROS/Nrf2/HO-1-SOD2-NQO-1-GCLC signaling axis is a key axis through which curcumin activates the Nrf2/ARE pathway in TMJ inflammatory chondrocytes.	Curcumin	112-120	heme oxygenase 1	Homo sapiens	48-57
32171585-0	2020	Corrigendum to "Biochemical and biophysical characterization of curcumin binding to human mitotic kinesin Eg5: Insights into the inhibitory mechanism of curcumin on Eg5" [Int.	Curcumin	64-72	kinesin family member 11	Homo sapiens	106-109
32334468-6	2020	This study aimed to evaluate the effect of curcumin (CUR) in comparison with trichostatin A (TSA) on estrogen receptor alpha (ERalpha) reactivation, apoptotic induction, and cell growth inhibition in HCC.	Curcumin	43-51	estrogen receptor 1 (alpha)	Mus musculus	101-124
32334468-6	2020	This study aimed to evaluate the effect of curcumin (CUR) in comparison with trichostatin A (TSA) on estrogen receptor alpha (ERalpha) reactivation, apoptotic induction, and cell growth inhibition in HCC.	Curcumin	43-51	estrogen receptor 1 (alpha)	Mus musculus	126-133
32334468-6	2020	This study aimed to evaluate the effect of curcumin (CUR) in comparison with trichostatin A (TSA) on estrogen receptor alpha (ERalpha) reactivation, apoptotic induction, and cell growth inhibition in HCC.	Curcumin	53-56	estrogen receptor 1 (alpha)	Mus musculus	101-124
32334468-6	2020	This study aimed to evaluate the effect of curcumin (CUR) in comparison with trichostatin A (TSA) on estrogen receptor alpha (ERalpha) reactivation, apoptotic induction, and cell growth inhibition in HCC.	Curcumin	53-56	estrogen receptor 1 (alpha)	Mus musculus	126-133
32124937-8	2020	Furthermore, curcumin mitigated the OGD/R-induced activation of phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway.	Curcumin	13-21	protein tyrosine kinase 2 beta	Homo sapiens	94-110
32228565-0	2020	Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter.	Curcumin	39-47	heme oxygenase 1	Homo sapiens	23-27
32228565-10	2020	Nrf2 production was also promoted to increase the expression of HO-1 and SOD2 by curcumin.	Curcumin	81-89	heme oxygenase 1	Homo sapiens	64-68
32230857-3	2020	Through a validation step using curcumin, which targets aminopeptidase N (APN), we successfully standardized the systematic strategy.	Curcumin	32-40	alanyl (membrane) aminopeptidase	Mus musculus	56-72
32230857-3	2020	Through a validation step using curcumin, which targets aminopeptidase N (APN), we successfully standardized the systematic strategy.	Curcumin	32-40	alanyl (membrane) aminopeptidase	Mus musculus	74-77
32721999-0	2020	Resveratrol, Curcumin and Piperine Alter Human Glyoxalase 1 in MCF-7 Breast Cancer Cells.	Curcumin	13-21	glyoxalase I	Homo sapiens	47-59
32721999-4	2020	In this scenario, the aim of this study was to investigate the effects of the bioactive compounds resveratrol, curcumin and piperine (R-C-P) on MCF-7 breast cancer cells and to associate them to Glyoxalase 1 (GLO1) activity.	Curcumin	111-119	glyoxalase I	Homo sapiens	195-207
32724322-0	2020	Curcumin Inhibits Hepatocellular Carcinoma via Regulating miR-21/TIMP3 Axis.	Curcumin	0-8	microRNA 21	Homo sapiens	58-64
32724322-3	2020	However, whether miR-21 plays a role in curcumin-mediated treatment of HCC is unknown.	Curcumin	40-48	microRNA 21	Homo sapiens	17-23
32724322-4	2020	The purpose of this study was to identify the potential functions and mechanisms of miR-21 in curcumin-mediated treatment of HCC.	Curcumin	94-102	microRNA 21	Homo sapiens	84-90
32724322-6	2020	The underlying mechanism of miR-21 in curcumin-mediated treatment of HCC was assessed by quantitative real-time PCR (RT-qPCR), western blot, and Dual-Luciferase Reporter assays.	Curcumin	38-46	microRNA 21	Homo sapiens	28-34
32724322-8	2020	Meanwhile, the curcumin treatment can downregulate miR-21 expression, upregulate TIMP3 expression, and inhibit the TGF-beta1/smad3 signaling pathway.	Curcumin	15-23	microRNA 21	Homo sapiens	51-57
32724322-9	2020	miR-21 inhibition enhanced the effect of curcumin on cell proliferation inhibition, apoptosis, and TGF-beta1/smad3 signaling pathway inhibition in HepG2 and HCCLM3 cells.	Curcumin	41-49	microRNA 21	Homo sapiens	0-6
32724322-11	2020	Interestingly, the effect of miR-21 inhibition on cell proliferation, apoptosis, and TGF-beta1/smad3 signaling pathway in HepG2 and HCCLM3 cells exposed to curcumin was attenuated by TIMP3 silencing.	Curcumin	156-164	microRNA 21	Homo sapiens	29-35
32724322-12	2020	Conclusion: Taken together, the present study suggests that miR-21 is involved in the anticancer activities of curcumin through targeting TIMP3, and the mechanism possibly refers to the inhibition of TGF-beta1/smad3 signaling pathway.	Curcumin	111-119	microRNA 21	Homo sapiens	60-66
32714183-0	2020	LincROR Mediates the Suppressive Effects of Curcumin on Hepatocellular Carcinoma Through Inactivating Wnt/beta-Catenin Signaling.	Curcumin	44-52	catenin beta 1	Homo sapiens	106-118
32714183-7	2020	Furthermore, Curcumin was found to decrease beta-catenin expression and induce the inactivation of Wnt/beta-catenin signaling.	Curcumin	13-21	catenin beta 1	Homo sapiens	44-56
32714183-7	2020	Furthermore, Curcumin was found to decrease beta-catenin expression and induce the inactivation of Wnt/beta-catenin signaling.	Curcumin	13-21	catenin beta 1	Homo sapiens	103-115
32714183-8	2020	Therefore, Curcumin suppressed tumor growth through a lincROR/beta-catenin regulatory pattern.	Curcumin	11-19	catenin beta 1	Homo sapiens	62-74
32714183-9	2020	In conclusion, our results demonstrated that Curcumin suppressed the cell proliferation via the down-regulation of lincROR and inactivation of Wnt/beta-catenin signaling, suggesting that it may be a potential anti-cancer candidate for HCC patients with activated Wnt/beta-catenin signaling.	Curcumin	45-53	catenin beta 1	Homo sapiens	147-159
32714183-9	2020	In conclusion, our results demonstrated that Curcumin suppressed the cell proliferation via the down-regulation of lincROR and inactivation of Wnt/beta-catenin signaling, suggesting that it may be a potential anti-cancer candidate for HCC patients with activated Wnt/beta-catenin signaling.	Curcumin	45-53	catenin beta 1	Homo sapiens	267-279
32485495-6	2020	RNA-seq results showed that acute H2O2 treatment resulted in minor changes in gene expression, whereas curcumin changed the expression profile and affected cytochrome P450 (Cyp 450), glutathione (GSH) metabolism, and the peroxisome proliferator-activated receptor (PPAR) signaling pathway.	Curcumin	103-111	peroxisome proliferator-activated receptor alpha	Oreochromis niloticus	221-263
32485495-6	2020	RNA-seq results showed that acute H2O2 treatment resulted in minor changes in gene expression, whereas curcumin changed the expression profile and affected cytochrome P450 (Cyp 450), glutathione (GSH) metabolism, and the peroxisome proliferator-activated receptor (PPAR) signaling pathway.	Curcumin	103-111	peroxisome proliferator-activated receptor alpha	Oreochromis niloticus	265-269
32485495-8	2020	These results indicate that curcumin might upregulate PPAR expression by increasing Cyp2J2 expression.	Curcumin	28-36	peroxisome proliferator-activated receptor alpha	Oreochromis niloticus	54-58
32485495-9	2020	Further experiments showed that curcumin can upregulate the Nrf2-Keap1 signaling pathway at the transcriptional level, and this upregulation can induce downstream defense genes, including glutamate cysteine ligase catalytic subunit(GCLC) and glutamate cysteine ligase modifier subunit (GCLM), and thereby promote GSH synthesis and the expression of related antioxidases.	Curcumin	32-40	glutamate--cysteine ligase catalytic subunit	Oreochromis niloticus	188-237
33018178-5	2020	In previous studies, we developed a new curcumin-conjugated magnetic nanoparticle (Cur-MNPs) to target the Abeta pathologies.	Curcumin	40-48	amyloid beta (A4) precursor protein	Mus musculus	107-112
31654258-8	2020	In addition, CUR and/or Se reduced serum C-reactive protein, liver pro-inflammatory cytokines, and the expression of TLR4, NF-kappaB, JNK, and p38, and upregulated heme oxygenase-1 (HO-1).	Curcumin	13-16	mitogen-activated protein kinase 8	Rattus norvegicus	134-137
32030812-8	2020	Application of topical curcumin also increased the expression level of RelA as the main subunit of the nuclear factor-kappaB (NF-kappaB) signalling pathway.	Curcumin	23-31	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	71-75
32348814-0	2020	Curcumin inhibits zearalenone-induced apoptosis and oxidative stress in Leydig cells via modulation of the PTEN/Nrf2/Bip signaling pathway.	Curcumin	0-8	phosphatase and tensin homolog	Homo sapiens	107-111
32361190-5	2020	The combination immunotherapy in the present of free form of curcumin or ovalbumin with encapsulated forms of the another substance (P.OVA-CUR 10 and P.CUR 5-OVA), showed the highest level of IFN-gamma:IL-4 compared to other target groups.	Curcumin	61-69	interleukin 4	Mus musculus	202-206
32377752-16	2020	In addition, curcumin and IL-6-neutralizing antibody treatment suppressed PSC-CM-modulated pancreatic cancer invasion, EMT and the changes in the expression of E-cadherin, vimentin and matrix metallopeptidase-9.	Curcumin	13-21	vimentin	Homo sapiens	172-180
32503208-0	2020	The Dual-Active Histamine H3 Receptor Antagonist and Acetylcholine Esterase Inhibitor E100 Alleviates Autistic-Like Behaviors and Oxidative Stress in Valproic Acid Induced Autism in Mice.	Curcumin	86-90	histamine receptor H3	Mus musculus	16-37
32236880-7	2020	Curcumin affected lipid order at different depths within the membrane: it slightly increased the phospholipid polar headgroup mobility as monitored by spectral parameters of T-PC, while along the acyl chain the ordering effect was observed in terms of order parameter S. Also, rotational correlation times tau2B and tau2C of 16-PC in the membrane center were increased by curcumin.	Curcumin	0-8	microtubule associated protein tau	Homo sapiens	306-309
32350681-7	2020	Importantly, curcumin significantly inhibited the BLM-induced increases in BALF and lung fibronectin levels.	Curcumin	13-21	fibronectin 1	Rattus norvegicus	89-100
32350681-8	2020	Treatment of BLM rats with curcumin dramatically suppressed alveolar macrophage release of fibronectin.	Curcumin	27-35	fibronectin 1	Rattus norvegicus	91-102
32391111-10	2020	Furthermore, curcumin was able to effectively inhibit the HGF-induced increase in the levels of vimentin by downregulating the expression of phosphorylated c-Met, an ERK.	Curcumin	13-21	vimentin	Homo sapiens	96-104
32596292-7	2020	There were significant decrements in IL-1beta, IL-6, and TNFalpha expression in both curcumin and Cur-CS nanoparticles.	Curcumin	85-93	interleukin 1 alpha	Felis catus	37-45
32596292-7	2020	There were significant decrements in IL-1beta, IL-6, and TNFalpha expression in both curcumin and Cur-CS nanoparticles.	Curcumin	85-93	tumor necrosis factor	Felis catus	57-65
21889563-6	2011	Treatment with free curcumin showed &lt;= 15% recovery in membrane lipids (LPO) and 22% recovery in acetylcholinesterase (AChE) with respect to AlCl(3) treated group.	Curcumin	20-28	acetylcholinesterase	Mus musculus	122-126
21732406-6	2011	Curcumin generated an aberrant RANKL signal characterized by reduced expression of nuclear factor of activated T cells 2 (NFAT2) and attenuated activation of mitogen-activated protein kinases (ERK, JNK, and p38).	Curcumin	0-8	mitogen-activated protein kinase 14	Mus musculus	207-210
21911894-0	2011	Alteration of AP-endonuclease1 expression in curcumin-treated fibrotic rats.	Curcumin	45-53	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	14-30
21189228-6	2011	Supplementation with rosiglitazone, a PPARgamma ligand, during the early stage of adipocyte differentiation partially rescued curcumin-inhibited adipocyte differentiation.	Curcumin	126-134	peroxisome proliferator activated receptor gamma	Mus musculus	38-47
21958395-10	2011	Several novel curcumin-induced genes including Netrin G1, Delta-like 1, Platelet endothelial cell adhesion molecule 1, and Plasma cell endoplasmic reticulum protein 1, have been previously associated with adhesion and cell migration.	Curcumin	14-22	platelet/endothelial cell adhesion molecule 1	Mus musculus	72-117
21958395-12	2011	Curcumin also potently blocked gene expression related to pro-inflammatory activation of resting cells including Toll-like receptor 2 and Prostaglandin-endoperoxide synthase 2.	Curcumin	0-8	toll-like receptor 2	Mus musculus	113-133
21958395-12	2011	Curcumin also potently blocked gene expression related to pro-inflammatory activation of resting cells including Toll-like receptor 2 and Prostaglandin-endoperoxide synthase 2.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	138-175
21325634-6	2011	First, all CCA cells exhibited constitutively active nuclear factor (NF)-kappaB, and treatment with curcumin abolished this activation as indicated by DNA binding, nuclear translocation and p65 phosphorylation.	Curcumin	100-108	RELA proto-oncogene, NF-kB subunit	Homo sapiens	190-193
21325634-11	2011	Sixth, curcumin inhibited expression of cell survival proteins such as B-cell lymphoma-2, B-cell leukemia protein xL, X-linked inhibitor of apoptosis protein, c-FLIP, cellular inhibitor of apoptosis protein (cIAP)-1, cIAP-2 and survivin and proteins linked to cell proliferation, such as cyclin D1 and c-Myc.	Curcumin	7-15	baculoviral IAP repeat containing 2	Homo sapiens	167-215
21325634-11	2011	Sixth, curcumin inhibited expression of cell survival proteins such as B-cell lymphoma-2, B-cell leukemia protein xL, X-linked inhibitor of apoptosis protein, c-FLIP, cellular inhibitor of apoptosis protein (cIAP)-1, cIAP-2 and survivin and proteins linked to cell proliferation, such as cyclin D1 and c-Myc.	Curcumin	7-15	cyclin D1	Homo sapiens	288-297
21347788-7	2011	Finally, we found that knocking down GRP78 causes resistance to curcumin treatment through the suppression of caspase-3 and caspase-8 expression levels.	Curcumin	64-72	caspase 8	Homo sapiens	124-133
21354353-8	2011	Curcumin pretreatment reduce pulmonary apoptotic pathway via significant inhibition of TGF-beta and caspase-3 in kidney and lung tissues.	Curcumin	0-8	caspase 3	Rattus norvegicus	100-109
32130010-5	2020	Inspired by the perspective on interactive orientation, we conjugated curcumin molecule on the positive-charged scaffold of Ru(II) complexes (bipyridine for Ru1, phenanthroline for Ru2) to construct an octahedral structure.	Curcumin	70-78	Scm like with four mbt domains 1	Homo sapiens	157-160
32130010-5	2020	Inspired by the perspective on interactive orientation, we conjugated curcumin molecule on the positive-charged scaffold of Ru(II) complexes (bipyridine for Ru1, phenanthroline for Ru2) to construct an octahedral structure.	Curcumin	70-78	doublecortin domain containing 2	Homo sapiens	181-184
21520062-6	2011	In addition, pretreatment with curcumin (a p300 inhibitor) or transfection with p300 siRNA blocked cPLA(2) expression and PGE(2) synthesis induced by TNF-alpha.	Curcumin	31-39	E1A binding protein p300	Homo sapiens	43-47
32130010-6	2020	After being conjugated with a ruthenium octahedral framework, curcumin exhibited a stronger ability to not only inhibit aggregation of R3, the tau peptide corresponding to the third repeat unit of the microtubule binding domain (residues 306-336 in full tau) (Ru1 with an IC50 of 0.5 muM and Ru2 with an IC50 of less than 3 muM) but also disaggregate R3 fibers with dose-dependence through an exothermic and dynamic process.	Curcumin	62-70	Scm like with four mbt domains 1	Homo sapiens	260-263
32130010-6	2020	After being conjugated with a ruthenium octahedral framework, curcumin exhibited a stronger ability to not only inhibit aggregation of R3, the tau peptide corresponding to the third repeat unit of the microtubule binding domain (residues 306-336 in full tau) (Ru1 with an IC50 of 0.5 muM and Ru2 with an IC50 of less than 3 muM) but also disaggregate R3 fibers with dose-dependence through an exothermic and dynamic process.	Curcumin	62-70	doublecortin domain containing 2	Homo sapiens	292-295
32207596-0	2022	Study on the mechanism of curcumin to reduce the inflammatory response of temporal lobe in Alzheimer"s disease by regulating miR-146a.	Curcumin	26-34	microRNA 146	Mus musculus	125-133
32207596-9	2022	After treatment with low dose curcumin, the level of miRNA-146a in APP/PS1 mice decreased significantly, and the expression of A beta and APP/PS1 in temporal lobe of mice detected by Western blot decreased significantly, the levels of IL-1 beta and iNOS protein decreased significantly, and the protein of CFH increased signifanctly.	Curcumin	30-38	presenilin 1	Mus musculus	71-74
32207596-9	2022	After treatment with low dose curcumin, the level of miRNA-146a in APP/PS1 mice decreased significantly, and the expression of A beta and APP/PS1 in temporal lobe of mice detected by Western blot decreased significantly, the levels of IL-1 beta and iNOS protein decreased significantly, and the protein of CFH increased signifanctly.	Curcumin	30-38	amyloid beta (A4) precursor protein	Mus musculus	127-133
32207596-9	2022	After treatment with low dose curcumin, the level of miRNA-146a in APP/PS1 mice decreased significantly, and the expression of A beta and APP/PS1 in temporal lobe of mice detected by Western blot decreased significantly, the levels of IL-1 beta and iNOS protein decreased significantly, and the protein of CFH increased signifanctly.	Curcumin	30-38	presenilin 1	Mus musculus	142-145
32207596-9	2022	After treatment with low dose curcumin, the level of miRNA-146a in APP/PS1 mice decreased significantly, and the expression of A beta and APP/PS1 in temporal lobe of mice detected by Western blot decreased significantly, the levels of IL-1 beta and iNOS protein decreased significantly, and the protein of CFH increased signifanctly.	Curcumin	30-38	interleukin 1 alpha	Mus musculus	235-244
21538854-4	2011	In addition, we demonstrated a relationship between curcumin treatment and the expression of VEGF, EGFR, ERK2, and Cyclin A at the transcriptional and translational levels.	Curcumin	52-60	cyclin A2	Mus musculus	115-123
32207596-11	2022	Low dose curcumin can significantly reduce the level of neuropro-inflammatory miR-146A, up-regulate the expression of CFH protein, inhibit the phenotype of M1 microglia, and play a role in the treatment of AD by promoting the phagocytosis and clearance mechanism of A beta.	Curcumin	9-17	microRNA 146a	Homo sapiens	78-86
32207596-11	2022	Low dose curcumin can significantly reduce the level of neuropro-inflammatory miR-146A, up-regulate the expression of CFH protein, inhibit the phenotype of M1 microglia, and play a role in the treatment of AD by promoting the phagocytosis and clearance mechanism of A beta.	Curcumin	9-17	amyloid beta (A4) precursor protein	Mus musculus	266-272
32184643-0	2020	Curcumin Inhibited Podocyte Cell Apoptosis and Accelerated Cell Autophagy in Diabetic Nephropathy via Regulating Beclin1/UVRAG/Bcl2.	Curcumin	0-8	beclin 1, autophagy related	Mus musculus	113-120
32184643-0	2020	Curcumin Inhibited Podocyte Cell Apoptosis and Accelerated Cell Autophagy in Diabetic Nephropathy via Regulating Beclin1/UVRAG/Bcl2.	Curcumin	0-8	UV radiation resistance associated gene	Mus musculus	121-126
32184643-12	2020	The autophagy-related proteins LC3, p62, Beclin1, UVRAG and ATG5 were significantly affected in DN mice by curcumin, along with reducing expression of pro-apoptotic protein Bax and caspase-3 and increasing anti-apoptotic protein Bcl-2.	Curcumin	107-115	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	31-34
32184643-12	2020	The autophagy-related proteins LC3, p62, Beclin1, UVRAG and ATG5 were significantly affected in DN mice by curcumin, along with reducing expression of pro-apoptotic protein Bax and caspase-3 and increasing anti-apoptotic protein Bcl-2.	Curcumin	107-115	beclin 1, autophagy related	Mus musculus	41-48
32184643-12	2020	The autophagy-related proteins LC3, p62, Beclin1, UVRAG and ATG5 were significantly affected in DN mice by curcumin, along with reducing expression of pro-apoptotic protein Bax and caspase-3 and increasing anti-apoptotic protein Bcl-2.	Curcumin	107-115	UV radiation resistance associated gene	Mus musculus	50-55
32184643-15	2020	Discussion: Together, the results showed that curcumin inhibited podocyte apoptosis and accelerated cell autophagy via regulating Beclin1/UVRAG/Bcl2.	Curcumin	46-54	beclin 1, autophagy related	Mus musculus	130-137
21538854-5	2011	We also noticed a reduction of Cyclin A and Cyclin B after curcumin treatment that had an effect on the cell cycle.	Curcumin	59-67	cyclin A2	Mus musculus	31-39
21538854-6	2011	Curcumin-induced inhibition of Cyclin A and Cyclin B likely results in decreased progression through S and G2/M phases.	Curcumin	0-8	cyclin A2	Mus musculus	31-39
21598989-0	2011	1,2,3,4,6-penta-O-galloyl-beta-D-glucose, quercetin, curcumin and lycopene induce cell-cycle arrest in MDA-MB-231 and BT474 cells through downregulation of Skp2 protein.	Curcumin	53-61	S-phase kinase associated protein 2	Homo sapiens	156-160
32184643-15	2020	Discussion: Together, the results showed that curcumin inhibited podocyte apoptosis and accelerated cell autophagy via regulating Beclin1/UVRAG/Bcl2.	Curcumin	46-54	UV radiation resistance associated gene	Mus musculus	138-143
31970343-0	2020	Signal-off electrochemiluminescence immunosensors based on the quenching effect between curcumin-conjugated Au nanoparticles encapsulated in ZIF-8 and CdS-decorated TiO2 nanobelts for insulin detection.	Curcumin	88-96	CDP-diacylglycerol synthase 1	Homo sapiens	151-154
21317540-6	2011	When the curcumin- or calphostin C-treated cells were lysed with buffer containing a detergent, the UGT protein levels did not decrease.	Curcumin	9-17	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	100-103
31970343-1	2020	A new strategy for the highly sensitive electrochemiluminescence (ECL) detection of insulin was developed based on curcumin-conjugated Au nanoparticles wrapped in zeolitic Zn2+-imidazolate cross-linked framework nanoparticles (Au-Cur/ZIF-8) quenching the ECL of CdS-decorated TiO2 nanobelts (CdS@TiO2).	Curcumin	115-123	CDP-diacylglycerol synthase 1	Homo sapiens	262-265
31972171-2	2020	Treatment of mouse epidermal JB-6 cells with curcumin resulted in the induction of HO-1 expression, and this was abrogated in cells transiently transfected with Nrf2 siRNA.	Curcumin	45-53	heme oxygenase 1	Homo sapiens	83-87
32061917-6	2020	RESULTS: CUR and CIP treatment prevented the S. aureus-induced mouse mastitis increase the levels of IL-2, IL-10, and IFN-gamma and decrease levels of IL-6, IL-8, and TNF-alpha.	Curcumin	9-12	interleukin 2	Mus musculus	101-105
32061917-7	2020	Additionally, RT-PCR results showed that 20 mug/mL curcumin inhibited the mRNA expression of TNF-alpha, IL-6, IL-1beta, TRAF6 and MEKK1 in murine mammary epithelial cells (MMECs).	Curcumin	51-59	interleukin 1 alpha	Mus musculus	110-118
21317540-7	2011	We found that curcumin or calphostin C treatment facilitated the degradation of UGT protein after the cells were collected in the absence of a detergent.	Curcumin	14-22	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	80-83
31720988-8	2020	Curcumin administration also restored the redox balance and phosphorylation status of P65-NF-kappaB.	Curcumin	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	86-99
21317540-8	2011	Finally, by in cellulo evaluation, we found that curcumin decreased UGT activity by the direct inhibitory effect, but calphostin C did not affect UGT activity.	Curcumin	49-57	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	68-71
31720988-9	2020	Additionally, the epicutaneously sensitized mice challenged with aerosolized OVA developed asthmatic features which were effectively thwarted back upon curcumin treatment as reflected by data on total/differential cells in BALF and mRNA expression of Th2 cytokines in lungs.	Curcumin	152-160	heart and neural crest derivatives expressed 2	Mus musculus	251-254
21631512-5	2011	Similarly, curcumin, parthenolide, and helenalin, but not resveratrol and (-)-epigallocatechin-3-gallate (EGCG), also inhibit NOD2 activation by interfering with NOD2 dimerization.	Curcumin	11-19	nucleotide binding oligomerization domain containing 2	Homo sapiens	126-130
31896509-0	2020	AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis.	Curcumin	33-41	glutathione peroxidase 4	Mus musculus	125-129
32210689-1	2020	The current study was aimed to study the effect of curcumin on the expression levels of brain glucose transporter 1 protein (GLUT1) and femoral muscle glucose transporter 4 protein (GLUT4), in addition to study its possible therapeutic role in ameliorating insulin resistance and the metabolic disturbance in the obese and type 2 diabetic male albino Wistar rat model.	Curcumin	51-59	solute carrier family 2 member 4	Rattus norvegicus	151-180
32210689-1	2020	The current study was aimed to study the effect of curcumin on the expression levels of brain glucose transporter 1 protein (GLUT1) and femoral muscle glucose transporter 4 protein (GLUT4), in addition to study its possible therapeutic role in ameliorating insulin resistance and the metabolic disturbance in the obese and type 2 diabetic male albino Wistar rat model.	Curcumin	51-59	solute carrier family 2 member 4	Rattus norvegicus	182-187
32210689-8	2020	Curcumin significantly up-regulated GLUT4 gene expression, compared to the diabetic control group.	Curcumin	0-8	solute carrier family 2 member 4	Rattus norvegicus	36-41
32210689-9	2020	In conclusions, these results indicate a therapeutic role of curcumin in improving the diabetic status, obesity and enhancing the expression of GLUT4 gene.	Curcumin	61-69	solute carrier family 2 member 4	Rattus norvegicus	144-149
32423101-0	2020	Curcumin Enhances the Antitumoral Effect Induced by the Recombinant Vaccinia Neu Vaccine (rV-neuT) in Mice with Transplanted Salivary Gland Carcinoma Cells.	Curcumin	0-8	erb-b2 receptor tyrosine kinase 2	Mus musculus	77-80
32375323-9	2020	Furthermore, OLETF rats exercised and fed curcumin had lower IL6, TNFalpha, and IL10 levels (indicators of inflammatory response) and lower levels of ER stress markers (BiP and CHOP) in the intestine than OLETF controls.	Curcumin	42-50	interleukin 10	Rattus norvegicus	80-84
21631512-5	2011	Similarly, curcumin, parthenolide, and helenalin, but not resveratrol and (-)-epigallocatechin-3-gallate (EGCG), also inhibit NOD2 activation by interfering with NOD2 dimerization.	Curcumin	11-19	nucleotide binding oligomerization domain containing 2	Homo sapiens	162-166
21595920-13	2011	Curcumin-induced apoptosis was associated with reduced expression of both Bcl-2 mRNA and protein, subsequent loss of MMP, and activation of caspase-3 followed by PARP degradation.	Curcumin	0-8	collagen type XI alpha 2 chain	Homo sapiens	162-166
22291761-6	2011	We performed LDH cytotoxicity assay to analyse whether SMN2 activating concentrations of caffeic acid, chlorogenic acid and curcumin were cytotoxic to fibroblasts.	Curcumin	124-132	survival of motor neuron 2, centromeric	Homo sapiens	55-59
32357811-4	2020	In the case of MAO-A umbelliferone, curcumin, caffeic acid, quercetin possessed dock score -8.001, -7.941, -7.357, -6.658 respectively.	Curcumin	36-44	monoamine oxidase A	Homo sapiens	15-20
32435141-8	2020	The method was linear between 44 and 261 ng mL-1, showing intra-day (2.05.6%) and inter-day (4.0-5.1%) precision with accuracy and selectiveness (curcumin tR = 8.7 min and internal standard tR = 13.9 min with relative recovery of 83.2%).	Curcumin	146-154	L1 cell adhesion molecule	Mus musculus	44-48
31947633-6	2020	Due to the pleotropic properties of curcumin, including anti-amyloid, anti-tau protein hyperphosphorylation, anti-inflammatory, anti-apoptotic, and neuroprotective action, as well as increasing neuronal lifespan and promoting neurogenesis, curcumin is a promising candidate for the treatment of post-ischemic neurodegeneration with misfolded proteins accumulation.	Curcumin	36-44	microtubule associated protein tau	Homo sapiens	75-78
31947633-6	2020	Due to the pleotropic properties of curcumin, including anti-amyloid, anti-tau protein hyperphosphorylation, anti-inflammatory, anti-apoptotic, and neuroprotective action, as well as increasing neuronal lifespan and promoting neurogenesis, curcumin is a promising candidate for the treatment of post-ischemic neurodegeneration with misfolded proteins accumulation.	Curcumin	240-248	microtubule associated protein tau	Homo sapiens	75-78
31947962-5	2020	Local intravaginal delivery of curcumin nanoparticles, but not intraperitoneal or oral delivery, reduced CpG-mediated inflammatory histopathology and decreased production of pro-inflammatory cytokines Interleukin (IL)-6, Tumor Necrosis Factor Alpha (TNF-alpha) and Monocyte Chemoattractant Protein-1 (MCP-1) in the FGT.	Curcumin	31-39	C-C motif chemokine ligand 2	Homo sapiens	265-299
31947962-5	2020	Local intravaginal delivery of curcumin nanoparticles, but not intraperitoneal or oral delivery, reduced CpG-mediated inflammatory histopathology and decreased production of pro-inflammatory cytokines Interleukin (IL)-6, Tumor Necrosis Factor Alpha (TNF-alpha) and Monocyte Chemoattractant Protein-1 (MCP-1) in the FGT.	Curcumin	31-39	C-C motif chemokine ligand 2	Homo sapiens	301-306
32037797-7	2020	Curcumin supplementation at 200 mg/kg up-regulated the levels of AKT, NGF, mTOR, Nrf2 and HO-1 mRNA, and concomitantly down-regulated Bax, caspases-3 and -9 mRNA; it also decreased caspase-3 and caspase-9 activity.	Curcumin	0-8	mechanistic target of rapamycin kinase	Mus musculus	75-79
22291761-7	2011	RESULTS: We found that caffeic acid and curcumin were more efficient than chlorogenic acid and increased full-length SMN2 mRNA levels 1.5 and 1.7-fold, respectively.	Curcumin	40-48	survival of motor neuron 2, centromeric	Homo sapiens	117-121
21161336-5	2011	RESULTS: We observed that CDF together with 5-FU + Ox were more potent than curcumin in reducing CD44 and CD166 in chemo-resistant colon cancer cells, accompanied by inhibition of growth, induction of apoptosis and disintegration of colonospheres.	Curcumin	76-84	activated leukocyte cell adhesion molecule	Homo sapiens	106-111
32095862-4	2020	It was found that curcumin administration tended to improve the spatial learning and memory abilities and reduce the amyloid plaque burden in the hippocampus of APP/PS1 mice.	Curcumin	18-26	presenilin 1	Mus musculus	165-168
32334468-0	2020	Effect of Curcumin in Comparison with Trichostatin A on the Reactivation of Estrogen Receptor Alpha gene Expression, Cell Growth Inhibition and Apoptosis Induction in Hepatocellular Carcinoma Hepa 1-6 Cell lLine.	Curcumin	10-18	estrogen receptor 1 (alpha)	Mus musculus	76-99
32220355-9	2020	Additionally, curcumin administration up-regulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) (P = 0.03) and low-density lipoprotein receptor (LDLR) (P < 0.001) compared with the placebo.	Curcumin	14-22	low density lipoprotein receptor	Homo sapiens	147-179
32417759-0	2020	Curcumin inhibits proliferation of hepatocellular carcinoma cells through down regulation of DJ-1.	Curcumin	0-8	Parkinsonism associated deglycase	Homo sapiens	93-97
32417759-11	2020	In conclusion, Cur inhibits proliferation of hepatocellular carcinoma cells and PTEN/PI3K/AKT signaling pathway via the reduction of DJ-1 expression, which provides new insights to the anticancer effects of curcumin in hepatocellular carcinoma.	Curcumin	207-215	phosphatase and tensin homolog	Homo sapiens	80-84
32417759-11	2020	In conclusion, Cur inhibits proliferation of hepatocellular carcinoma cells and PTEN/PI3K/AKT signaling pathway via the reduction of DJ-1 expression, which provides new insights to the anticancer effects of curcumin in hepatocellular carcinoma.	Curcumin	207-215	Parkinsonism associated deglycase	Homo sapiens	133-137
32220355-9	2020	Additionally, curcumin administration up-regulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) (P = 0.03) and low-density lipoprotein receptor (LDLR) (P < 0.001) compared with the placebo.	Curcumin	14-22	low density lipoprotein receptor	Homo sapiens	181-185
32220355-10	2020	CONCLUSIONS: Overall, curcumin administration for 12 weeks to women with PCOS had beneficial effects on body weight, glycemic control, serum lipids except triglycerides and VLDL-cholesterol levels, and gene expression of PPAR-gamma and LDLR.	Curcumin	22-30	low density lipoprotein receptor	Homo sapiens	236-240
21187084-11	2011	Furthermore, curcumin reduced the intracellular signaling proteins Ras, B-raf, p-MEK, p-ERK, c-fos, Egr-1, but increased Raf-1 and NAB2 in MDCK cells exposed to forskolin.	Curcumin	13-21	Raf-1 proto-oncogene, serine/threonine kinase	Canis lupus familiaris	121-126
31945443-6	2020	Also, beta-CD/CUR-MBN exerted a prolonged cytotoxic effect (up to 96 h), even using a low concentration (50 mug mL-1), indicating that the curcumin in the polymeric membrane showed increased bioavailability under the tested condition.	Curcumin	139-147	L1 cell adhesion molecule	Mus musculus	112-116
31995010-6	2020	RESULTS: As a result of comprehensive appraisal of molecular properties and dynamics of the complexes, it is concluded that Chebulic acid, Curcumin and Mulberroside C could be develop as envelope glycoprotein GP120 inhibitor, reverse transcriptase inhibitor and protease inhibitor respectively.	Curcumin	139-147	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	209-214
32337261-5	2020	Results: Curcumin was found to suppress the proliferation of LECs by inducing G2/M arrest via possible inhibition of cell cycle-related proteins including CDK1, cyclin B1, and CDC25C.	Curcumin	9-17	cyclin dependent kinase 1	Homo sapiens	155-159
20883815-7	2011	Up-regulation of Cyclin-D1, Cox-2, XIAP and cIAP1 and phosphorylation of MAPKs, were completely inhibited on inactivation of NF-kappaB assigning a key regulatory role to NF-kappaB in the synergistic effect of paclitaxel and curcumin.	Curcumin	224-232	cyclin D1	Homo sapiens	17-26
32337261-5	2020	Results: Curcumin was found to suppress the proliferation of LECs by inducing G2/M arrest via possible inhibition of cell cycle-related proteins including CDK1, cyclin B1, and CDC25C.	Curcumin	9-17	cyclin B1	Homo sapiens	161-170
32337261-5	2020	Results: Curcumin was found to suppress the proliferation of LECs by inducing G2/M arrest via possible inhibition of cell cycle-related proteins including CDK1, cyclin B1, and CDC25C.	Curcumin	9-17	cell division cycle 25C	Homo sapiens	176-182
31881321-12	2020	We also found that NF-kappaB pathway is activated in the kidney of NS rats, and curcumin can inhibit the activation of NF-kappaB by down-regulating the expression of NF-kappaB p65, reducing the level of p-IkappaBalpha and up-regulating the expression of IkappaBalpha.	Curcumin	80-88	NFKB inhibitor alpha	Rattus norvegicus	205-217
31441735-0	2020	Curcumin Suppresses Epithelial Growth Factor Receptor (EGFR) and Proliferative Protein (Ki 67) in Acute Lung Injury and Lung Fibrosis In Vitro and In Vivo.	Curcumin	0-8	epidermal growth factor receptor	Mus musculus	20-53
31441735-0	2020	Curcumin Suppresses Epithelial Growth Factor Receptor (EGFR) and Proliferative Protein (Ki 67) in Acute Lung Injury and Lung Fibrosis In Vitro and In Vivo.	Curcumin	0-8	epidermal growth factor receptor	Mus musculus	55-59
31441735-3	2020	OBJECTIVE: The aim of the study was to evaluate effect of curcumin as an intervention on two prognostic markers EGFR and Ki67 in bleomycin induced basal alveolar epithelial cells and C57BL/6 mice.	Curcumin	58-66	epidermal growth factor receptor	Mus musculus	112-116
31441735-8	2020	KEY FINDINGS: The natural polyphenol curcumin could downregulate the expressions levels of Ki67 and EGFR both in vitro and in vivo.	Curcumin	37-45	epidermal growth factor receptor	Mus musculus	100-104
31441735-10	2020	The pathological sections from treated lungs showed significant decrease in EGFR and Ki67 levels when exposed to curcumin.	Curcumin	113-121	epidermal growth factor receptor	Mus musculus	76-80
31441735-11	2020	CONCLUSION: We conclude that curcumin, well-known natural bioactive compound holds strong anti-proliferative on Ki67 and EGFR expressions.We observed that, a clinical outcome in diagnosis of pulmonary fibrosis remains to be unconvincing so far.	Curcumin	29-37	epidermal growth factor receptor	Mus musculus	121-125
31881321-12	2020	We also found that NF-kappaB pathway is activated in the kidney of NS rats, and curcumin can inhibit the activation of NF-kappaB by down-regulating the expression of NF-kappaB p65, reducing the level of p-IkappaBalpha and up-regulating the expression of IkappaBalpha.	Curcumin	80-88	NFKB inhibitor alpha	Rattus norvegicus	254-266
20883815-7	2011	Up-regulation of Cyclin-D1, Cox-2, XIAP and cIAP1 and phosphorylation of MAPKs, were completely inhibited on inactivation of NF-kappaB assigning a key regulatory role to NF-kappaB in the synergistic effect of paclitaxel and curcumin.	Curcumin	224-232	baculoviral IAP repeat containing 2	Homo sapiens	44-49
31991125-9	2020	Inhibition of CSN5 kinase activity by curcumin decreased HK2 protein expression and glycolysis, repressed the metastasis of HCC cells in vitro and in vivo, and prolonged the survival time of tumor-bearing nude mice.	Curcumin	38-46	hexokinase 2	Mus musculus	57-60
20848615-8	2011	Conversely, non-modification of p53 expression was observed and cyclo-oxygenase-2 and inducible nitric oxide synthase were significantly reduced in the curcumin diet-DSS group.	Curcumin	152-160	prostaglandin-endoperoxide synthase 2	Mus musculus	64-81
21445800-2	2011	Pyridyl (D12, D13), furyl (D56), and phenyl (D68) derivatives of curcumin semi-carbazones were found to provide the highest dose modifying factors (DMF) with respect to survival in sub-TBI (bone marrow sparing) exposures in mouse models.	Curcumin	65-73	granzyme E	Mus musculus	9-12
31812013-4	2020	Nutraceuticals like berberine, curcumin and polydatin have been found effective in modulating PCSK9 expression by lowering LDL levels.	Curcumin	31-39	proprotein convertase subtilisin/kexin type 9	Homo sapiens	94-99
32054357-7	2020	Annexin-V analysis by flow cytometry revealed 2- to 6-fold increases in annexin-V-positive cells in Dox-treated MCF7 and HCT116 cells by Cur (15 microM), Caff (10 mM), and TQ (50 microM; P &lt; .001).	Curcumin	137-140	annexin A5	Homo sapiens	0-9
32054357-7	2020	Annexin-V analysis by flow cytometry revealed 2- to 6-fold increases in annexin-V-positive cells in Dox-treated MCF7 and HCT116 cells by Cur (15 microM), Caff (10 mM), and TQ (50 microM; P &lt; .001).	Curcumin	137-140	annexin A5	Homo sapiens	72-81
31944660-4	2020	In the present study, we have designed and prepared a novel multifunctional combined therapy nanoparticle (ZnPc@Cur-S-OA NPs), in which curcumin (Cur) was not only used as a chemotherapy drug to achieve a combination therapy with PDT via downregulating HIF-1alpha and depleting GSH in B16F10 cells but also designed as a small-molecule ROS-triggered release prodrug to deliver the photosensitizer (PS).	Curcumin	136-144	hypoxia inducible factor 1, alpha subunit	Mus musculus	253-263
20869986-11	2011	Meanwhile, pretreatment with curcumin abrogated cytochrome c release, blocked activation of Caspase-3, and altered the expression of Bcl-2 family triggered by ONOO(-).	Curcumin	29-37	caspase 3	Rattus norvegicus	92-101
31868679-4	2020	METHODS: Nanocarriers of curcumin and/or DFO were prepared using Pluronic F68 (P68) with or without dequilinium (DQA) by modified thin-film hydration.	Curcumin	25-33	DEAD-box helicase 5	Homo sapiens	65-77
21034749-11	2010	SIGNIFICANCE: p300 interacts with cardiac-specific genes, GATA4, Nkx2.5 and Mef2c, and inhibition of p300-HAT by curcumin down-regulates their expression through the inhibition of histone H3 acetylation in the promoter regions.	Curcumin	113-121	NK2 homeobox 5	Mus musculus	65-71
31612448-4	2020	Here we describe the characterization beta-casein nanocarriers encapsulating a model hydrophobic compound, 8-anilino-1-naphthalenesulfonic acid, and the natural bioactive curcumin using the Malvern NanoSight NS300.	Curcumin	171-179	casein beta	Homo sapiens	38-49
31887796-0	2020	Curcumin Inhibits the Proliferation, Migration, Invasion, and Apoptosis of Diffuse Large B-Cell Lymphoma Cell Line by Regulating MiR-21/VHL Axis.	Curcumin	0-8	microRNA 21	Homo sapiens	129-135
20937840-7	2010	The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.	Curcumin	25-33	interleukin 1 receptor associated kinase 1	Homo sapiens	132-138
31887796-3	2020	Here, we aimed to further explore the mechanistic insight into the link between curcumin and miR-21 on diffuse large B-cell lymphoma (DLBCL).	Curcumin	80-88	microRNA 21	Homo sapiens	93-99
31887796-10	2020	Curcumin inhibited miR-21 expression and curcumin exerted its anti-proliferation, anti-migration, anti-invasion, and pro-apoptosis effects by miR-21 in SU-DHL-8 cells.	Curcumin	0-8	microRNA 21	Homo sapiens	19-25
20717830-9	2010	The elevation of ECM and TGF-beta1/p-SMAD-2 level was substantially blocked by the cellular uptake of curcumin in a dose-dependent manner in all the seven primary KFs.	Curcumin	102-110	SMAD family member 2	Homo sapiens	37-43
31887796-10	2020	Curcumin inhibited miR-21 expression and curcumin exerted its anti-proliferation, anti-migration, anti-invasion, and pro-apoptosis effects by miR-21 in SU-DHL-8 cells.	Curcumin	41-49	microRNA 21	Homo sapiens	142-148
31887796-13	2020	CONCLUSION: Curcumin exerted its anti-proliferation, anti-migration, anti-invasion, and pro-apoptosis functions, at least partly, by repressing miR-21 and regulating VHL expression in DLBCL cell line.	Curcumin	12-20	microRNA 21	Homo sapiens	144-150
31878265-7	2019	Dietary supplementation with 200 mg/kg curcumin significantly reduced cysteinyl aspartate specific proteinase 3 (caspase3), BCL2-associated X protein (bax), B-cellCLL/lymphoma 2 (bcl2), and heat-shock protein 70 (hsp70) mRNA expression, and increased occludin (ocln) mRNA expression (p &lt; 0.05).	Curcumin	39-47	apoptosis regulator BAX	Sus scrofa	124-149
31878265-7	2019	Dietary supplementation with 200 mg/kg curcumin significantly reduced cysteinyl aspartate specific proteinase 3 (caspase3), BCL2-associated X protein (bax), B-cellCLL/lymphoma 2 (bcl2), and heat-shock protein 70 (hsp70) mRNA expression, and increased occludin (ocln) mRNA expression (p &lt; 0.05).	Curcumin	39-47	apoptosis regulator BAX	Sus scrofa	151-154
31878265-7	2019	Dietary supplementation with 200 mg/kg curcumin significantly reduced cysteinyl aspartate specific proteinase 3 (caspase3), BCL2-associated X protein (bax), B-cellCLL/lymphoma 2 (bcl2), and heat-shock protein 70 (hsp70) mRNA expression, and increased occludin (ocln) mRNA expression (p &lt; 0.05).	Curcumin	39-47	apoptosis regulator Bcl-2	Sus scrofa	157-177
31878265-7	2019	Dietary supplementation with 200 mg/kg curcumin significantly reduced cysteinyl aspartate specific proteinase 3 (caspase3), BCL2-associated X protein (bax), B-cellCLL/lymphoma 2 (bcl2), and heat-shock protein 70 (hsp70) mRNA expression, and increased occludin (ocln) mRNA expression (p &lt; 0.05).	Curcumin	39-47	apoptosis regulator Bcl-2	Sus scrofa	179-183
31878265-7	2019	Dietary supplementation with 200 mg/kg curcumin significantly reduced cysteinyl aspartate specific proteinase 3 (caspase3), BCL2-associated X protein (bax), B-cellCLL/lymphoma 2 (bcl2), and heat-shock protein 70 (hsp70) mRNA expression, and increased occludin (ocln) mRNA expression (p &lt; 0.05).	Curcumin	39-47	occludin	Sus scrofa	251-259
31878265-7	2019	Dietary supplementation with 200 mg/kg curcumin significantly reduced cysteinyl aspartate specific proteinase 3 (caspase3), BCL2-associated X protein (bax), B-cellCLL/lymphoma 2 (bcl2), and heat-shock protein 70 (hsp70) mRNA expression, and increased occludin (ocln) mRNA expression (p &lt; 0.05).	Curcumin	39-47	occludin	Sus scrofa	261-265
21311680-2	2010	We found that curcumin, a polyphenolic phytochemical isolated from the plant Curcuma longa, markedly suppressed E2F4 expression in HCT116 colon cancer cells.	Curcumin	14-22	E2F transcription factor 4	Homo sapiens	112-116
21311680-4	2010	Involvement of ROS in E2F4 downregulation in response to curcumin was confirmed by the result that pretreatment of cells with N-acetylcystein (NAC) before exposure of curcumin almost completely blocked the reduction of E2F4 expression at the protein as well as mRNA level.	Curcumin	57-65	E2F transcription factor 4	Homo sapiens	22-26
21311680-4	2010	Involvement of ROS in E2F4 downregulation in response to curcumin was confirmed by the result that pretreatment of cells with N-acetylcystein (NAC) before exposure of curcumin almost completely blocked the reduction of E2F4 expression at the protein as well as mRNA level.	Curcumin	57-65	E2F transcription factor 4	Homo sapiens	219-223
21311680-4	2010	Involvement of ROS in E2F4 downregulation in response to curcumin was confirmed by the result that pretreatment of cells with N-acetylcystein (NAC) before exposure of curcumin almost completely blocked the reduction of E2F4 expression at the protein as well as mRNA level.	Curcumin	167-175	E2F transcription factor 4	Homo sapiens	22-26
31590042-14	2019	Curcumin treatment switched the M1 pro-inflammatory phenotype to the M2 anti-inflammatory phenotype by decreasing the expression of M1 markers (i.e., iNOS, IL-1beta, IL-6, and CD16/32) and elevating the expression of M2 markers (i.e., arginase 1, IL-4, IL-10, and CD206).	Curcumin	0-8	interleukin 1 alpha	Mus musculus	156-164
21311680-6	2010	Expression of several genes, cyclin A, p21, and p27, which has been shown to be regulated in E2F4-dependent manner and involved in the cell cycle progression was also affected by curcumin.	Curcumin	179-187	E2F transcription factor 4	Homo sapiens	93-97
31590042-14	2019	Curcumin treatment switched the M1 pro-inflammatory phenotype to the M2 anti-inflammatory phenotype by decreasing the expression of M1 markers (i.e., iNOS, IL-1beta, IL-6, and CD16/32) and elevating the expression of M2 markers (i.e., arginase 1, IL-4, IL-10, and CD206).	Curcumin	0-8	interleukin 4	Mus musculus	247-251
20977462-12	2010	CONCLUSIONS AND IMPLICATIONS: Curcumin prevented leptin from elevating levels of intracellular glucose in activated HSCs in vitro by inhibiting the membrane translocation of GLUT4 and stimulating glucose conversion, leading to the inhibition of HSC activation.	Curcumin	30-38	solute carrier family 2 member 4	Homo sapiens	174-179
31819412-2	2019	The aim of this study was to assess the anti-inflammatory comparative effect of curcumin solution with liposomal curcumin formula, regarding the improvement of serum levels of TNF-alpha (tumor necrosis factor-alpha), IL-6 (interleukin), IL-1alpha, IL-1beta, MCP-1 (monocyte chemoattractant protein-1) and RANTES in experimental diabetes, induced by streptozotocin (STZ), in rats.	Curcumin	80-88	C-C motif chemokine ligand 2	Rattus norvegicus	258-263
31819412-2	2019	The aim of this study was to assess the anti-inflammatory comparative effect of curcumin solution with liposomal curcumin formula, regarding the improvement of serum levels of TNF-alpha (tumor necrosis factor-alpha), IL-6 (interleukin), IL-1alpha, IL-1beta, MCP-1 (monocyte chemoattractant protein-1) and RANTES in experimental diabetes, induced by streptozotocin (STZ), in rats.	Curcumin	80-88	C-C motif chemokine ligand 2	Rattus norvegicus	265-299
31694300-8	2019	CUR and/or AA ameliorated liver function, prevented tissue injury, and suppressed oxidative stress, DNA damage, NF-kappaB, JNK and caspase-3.	Curcumin	0-3	mitogen-activated protein kinase 8	Rattus norvegicus	123-126
20878113-0	2010	Curcumin promotes apoptosis in human lung adenocarcinoma cells through miR-186* signaling pathway.	Curcumin	0-8	microRNA 186	Homo sapiens	71-78
31577640-5	2019	Mechanistic studies have revealed superoxide dismutase, heme oxygenase-1 and nuclear factor erythroid 2-related factor 2 as emerging targets for the beneficial effects of curcumin on the vasculature.	Curcumin	171-179	heme oxygenase 1	Homo sapiens	56-120
20885979-0	2010	Curcumin protects intestinal mucosal barrier function of rat enteritis via activation of MKP-1 and attenuation of p38 and NF-kappaB activation.	Curcumin	0-8	mitogen activated protein kinase 14	Rattus norvegicus	114-117
31016760-0	2019	Curcumin ameliorates atherosclerosis through upregulation of miR-126.	Curcumin	0-8	microRNA 126	Homo sapiens	61-68
31016760-4	2019	The regulatory effects of curcumin on miR-126 and signaling pathways involved in AS were then studied.	Curcumin	26-34	microRNA 126	Homo sapiens	38-45
31016760-9	2019	miR-126 was upregulated by curcumin.	Curcumin	27-35	microRNA 126	Homo sapiens	0-7
21067307-3	2010	Our aim was to investigate whether curcumin alters h-IAPP misfolding and protects from cellular toxicity at physiologically relevant concentrations.	Curcumin	35-43	islet amyloid polypeptide	Homo sapiens	53-57
31016760-10	2019	The abovementioned effects of curcumin on HMEC-1 cells were all attenuated when miR-126 was silenced.	Curcumin	30-38	microRNA 126	Homo sapiens	80-87
31016760-11	2019	And also, VEGF was a target gene of miR-126, and curcumin could inhibit the activation of PI3K/AKT JAK2/STAT5 signaling pathways via miR-126.	Curcumin	49-57	microRNA 126	Homo sapiens	36-43
31016760-11	2019	And also, VEGF was a target gene of miR-126, and curcumin could inhibit the activation of PI3K/AKT JAK2/STAT5 signaling pathways via miR-126.	Curcumin	49-57	signal transducer and activator of transcription 5A	Homo sapiens	104-109
31016760-11	2019	And also, VEGF was a target gene of miR-126, and curcumin could inhibit the activation of PI3K/AKT JAK2/STAT5 signaling pathways via miR-126.	Curcumin	49-57	microRNA 126	Homo sapiens	133-140
31016760-12	2019	The effects of curcumin and its regulation on miR-126 and VEGF were confirmed in the animal model of AS.	Curcumin	15-23	microRNA 126	Homo sapiens	46-53
31016760-13	2019	To sum up, curcumin exerted potent anti-AS property possibly via upregulating miR-126 and thereby inhibiting PI3K/AKT and JAK2/STAT5 signaling pathways.	Curcumin	11-19	microRNA 126	Homo sapiens	78-85
31016760-13	2019	To sum up, curcumin exerted potent anti-AS property possibly via upregulating miR-126 and thereby inhibiting PI3K/AKT and JAK2/STAT5 signaling pathways.	Curcumin	11-19	signal transducer and activator of transcription 5A	Homo sapiens	127-132
21067307-4	2010	The effect of curcumin on h-IAPP misfolding in vitro was investigated by electron paramagnetic resonance spectroscopy, ThT fluorescence and electron microscopy.	Curcumin	14-22	islet amyloid polypeptide	Homo sapiens	28-32
31665675-5	2019	We also found that TNF-alpha-enhanced protein expressions of vascular cell adhesion molecule 1 (VCAM-1), monocyte chemotactic protein-1 (MCP-1) and nuclear factor (NF)-kappaB translocation were synergistically reduced by the combined curcumin and luteolin in EA.hy 926 cells while the individual chemical did not have this inhibitory effect.	Curcumin	234-242	C-C motif chemokine ligand 2	Homo sapiens	105-135
31665675-6	2019	Consistently, 2 weeks dietary intake of combined curcumin (500 mg/kg) and luteolin (500 mg/kg) in C57BL/6 mice synergistically prevented TNF-alpha-stimulated adhesion of mouse monocytes to aortic endothelium ex vivo as well as the TNF-alpha-increased aortic protein expression of MCP-1 and VCAM-1.	Curcumin	49-57	vascular cell adhesion molecule 1	Mus musculus	290-296
31665675-7	2019	Therefore, combined curcumin and luteolin at physiological concentrations synergistically inhibits TNF-alpha-induced monocytes adhesion to endothelial cells and expressions of MCP-1 and VCAM-1 via suppressing NF-kappaB translocation into the nucleus.	Curcumin	20-28	C-C motif chemokine ligand 2	Homo sapiens	176-181
21067307-5	2010	Our in vitro studies revealed that curcumin significantly reduces h-IAPP fibril formation and aggregates formed in the presence of curcumin display alternative morphology and structure.	Curcumin	35-43	islet amyloid polypeptide	Homo sapiens	68-72
21067307-6	2010	We then tested a potential protective effect of curcumin against h-IAPP toxicity on beta-cells.	Curcumin	48-56	islet amyloid polypeptide	Homo sapiens	67-71
21067307-7	2010	Micromolar concentrations of curcumin partially protect INS cells from exogenous IAPP toxicity.	Curcumin	29-37	islet amyloid polypeptide	Homo sapiens	81-85
20538607-3	2010	In addition, curcumin decreased expression of p50 and p65 proteins and NFkappaB-dependent transactivation and also decreased Sp1, Sp3, and Sp4 transcription factors that are overexpressed in pancreatic cancer cells.	Curcumin	13-21	RELA proto-oncogene, NF-kB subunit	Homo sapiens	54-57
20596635-5	2010	Pretreatment with the p38 inhibitor (SB203580) blocked LRE-induced AP-1 transcriptional activity, and curcumin, AP-1 inhibitor, dramatically inhibited LRE-induced apoptosis in B16F10 melanoma cells.	Curcumin	102-110	jun proto-oncogene	Mus musculus	112-116
31340709-5	2019	Studying the mechanism of action indicated that OCT-modified curcumin plus docetaxel micelles downregulated MMP-2 and HIF-1alpha.	Curcumin	61-69	hypoxia inducible factor 1, alpha subunit	Mus musculus	118-128
31443943-8	2019	Overall, our findings suggested that pre-treatment with curcumin extracts increased antioxidant status, reduced EB3 cross-linking, and improved erythrocyte deformability, to an even better extent than vitamin C.	Curcumin	56-64	microtubule associated protein RP/EB family member 3	Homo sapiens	112-115
20399909-0	2010	COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone marrow-derived dendritic cells.	Curcumin	78-86	cytochrome c oxidase II, mitochondrial	Mus musculus	0-5
31584928-0	2019	Curcumin Inhibits Cell Viability and Increases Apoptosis of SW620 Human Colon Adenocarcinoma Cells via the Caudal Type Homeobox-2 (CDX2)/Wnt/beta-Catenin Pathway.	Curcumin	0-8	catenin beta 1	Homo sapiens	141-153
31584928-9	2019	RESULTS Curcumin reduced cell viability and increased apoptosis of SW620 human colonic adenocarcinoma cells in a dose-dependent way, and increased the expression of CDX2 but decreased ss-catenin nuclear translocation and the expression of Wnt3a, c-Myc, survivin, and cyclin D1.	Curcumin	8-16	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	246-251
31236854-5	2019	Among them, miR-1246 was the miRNA with the largest change in expression after curcumin treatment.	Curcumin	79-87	microRNA 1246	Homo sapiens	12-20
31236854-7	2019	miR-1246 expression was significantly higher in T24 cells than in SV-HUC-1 cells and the higher concentrations (10 or 20 muM) of curcumin significantly down-regulated miR-1246 expression in T24 and HT-1376 cells.	Curcumin	129-137	microRNA 1246	Homo sapiens	0-8
31236854-7	2019	miR-1246 expression was significantly higher in T24 cells than in SV-HUC-1 cells and the higher concentrations (10 or 20 muM) of curcumin significantly down-regulated miR-1246 expression in T24 and HT-1376 cells.	Curcumin	129-137	microRNA 1246	Homo sapiens	167-175
31236854-8	2019	The combination of 10 microM curcumin and irradiation was more effective in decreasing miR-1246 expression, cell viability and colony formation than curcumin or irradiation alone.	Curcumin	29-37	microRNA 1246	Homo sapiens	87-95
20399909-3	2010	The effect of curcumin relative to LPS is not limited to the above, as it also enhances LPS-induced expression of cyclooxygenase (COX)-2 and production of prostaglandin E2 (PGE2).	Curcumin	14-22	cytochrome c oxidase II, mitochondrial	Mus musculus	114-136
31236854-12	2019	CONCLUSION: miR-1246 is involved in the anti-cancer effects of curcumin and irradiation through targeting the inhibition of p53 gene translation in bladder cancer cells.	Curcumin	63-71	microRNA 1246	Homo sapiens	12-20
20399909-5	2010	Under our experimental conditions, curcumin plays an immunomodulatory role by downregulating IDO expression via a COX-2/PGE2-dependant pathway, thus impacting DC maturation in vitro and in vivo.	Curcumin	35-43	cytochrome c oxidase II, mitochondrial	Mus musculus	114-119
20357182-4	2010	Curcumin inhibited mitogen-activated protein kinase (MAPK) (ERK, JNK, and p38) phosphorylation that was associated with differentiation of 3T3-L1 cells into adipocytes.	Curcumin	0-8	mitogen-activated protein kinase 14	Mus musculus	74-77
20357182-7	2010	Accordingly, quantitative PCR analysis revealed that curcumin inhibited the mRNA expression of AP2 (mature adipocyte marker) and increased the mRNA expression of Wnt10b, Fz2 (Wnt direct receptor), and LRP5 (Wnt coreceptor).	Curcumin	53-61	transcription factor AP-2, alpha	Mus musculus	95-98
31358480-0	2019	Curcumin inhibits NF-kB and Wnt/beta-catenin pathways in cervical cancer cells.	Curcumin	0-8	catenin beta 1	Homo sapiens	32-44
31358480-7	2019	It was also shown that curcumin either considerably affects the Wnt/beta-catenin and NF-kB pathways.	Curcumin	23-31	catenin beta 1	Homo sapiens	68-80
20357182-7	2010	Accordingly, quantitative PCR analysis revealed that curcumin inhibited the mRNA expression of AP2 (mature adipocyte marker) and increased the mRNA expression of Wnt10b, Fz2 (Wnt direct receptor), and LRP5 (Wnt coreceptor).	Curcumin	53-61	frizzled class receptor 2	Mus musculus	170-173
31358480-8	2019	We showed that curcumin inhibits invasion and proliferation of cervical cancer cells via impairment of NF-kB and Wnt/beta-catenin pathways, proposing further studies on the potential impacts of this compound on cancer therapy.	Curcumin	15-23	catenin beta 1	Homo sapiens	117-129
20357182-7	2010	Accordingly, quantitative PCR analysis revealed that curcumin inhibited the mRNA expression of AP2 (mature adipocyte marker) and increased the mRNA expression of Wnt10b, Fz2 (Wnt direct receptor), and LRP5 (Wnt coreceptor).	Curcumin	53-61	low density lipoprotein receptor-related protein 5	Mus musculus	201-205
20456495-5	2010	Primary human keratinocytes treated with curcumin or THC demonstrated decreased activation of p44/42 MAP kinases but increased levels of activated p38 MAP kinases.	Curcumin	41-49	interferon induced protein 44	Homo sapiens	94-97
20235152-7	2010	Compared to normal cells baseline expression of SOCS-3 was high in cancer cells and a marked decrease in SOCS-3 expression was seen following curcumin treatment.	Curcumin	142-150	suppressor of cytokine signaling 3	Homo sapiens	48-54
31407496-1	2020	In this work a new highly fluorescent N,N-dimethyl benzylamine-palladium(II) yu complex was synthesized by the reaction of [Pd2 {(C,N-C6 H4 CH2 N(CH3 )2 }2 (mu-OAc)]2 ] with curcumin.	Curcumin	174-182	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	124-127
32036964-14	2020	The curcumin group had the lowest expression of FAS and PPARG mRNA (P &lt; 0.05) and the highest expression of NRF2 and HMOX1 mRNA.	Curcumin	4-12	heme oxygenase 1	Anas platyrhynchos	120-125
20235152-7	2010	Compared to normal cells baseline expression of SOCS-3 was high in cancer cells and a marked decrease in SOCS-3 expression was seen following curcumin treatment.	Curcumin	142-150	suppressor of cytokine signaling 3	Homo sapiens	105-111
20372842-8	2010	Furthermore, curcumin also induced a dose-dependent cleavage of PARP.	Curcumin	13-21	collagen type XI alpha 2 chain	Homo sapiens	64-68
32051864-0	2020	Curcumin enhances chemotherapeutic effects and suppresses ANGPTL4 in anoikis-resistant cholangiocarcinoma cells.	Curcumin	0-8	angiopoietin like 4	Homo sapiens	58-65
32051864-11	2020	In addition, curcumin treatment decreased phosphorylated STAT3 and expression levels of Mcl-1, HDACs and ANGPTL4.	Curcumin	13-21	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	88-93
20395211-5	2010	We show that four compounds, genistein, curcumin, EGCG, and resveratrol, inhibit Hedgehog signaling as monitored by real-time reverse transcription-PCR analysis of Gli1 mRNA concentration or by Gli reporter activity.	Curcumin	40-48	GLI-Kruppel family member GLI1	Mus musculus	164-168
31864780-0	2020	Corrigendum to "Biochemical and Biophysical characterization of curcumin binding to human mitotic kinesin Eg5: Insights into the inhibitory mechanism of curcumin on Eg5" [Int.	Curcumin	64-72	kinesin family member 11	Homo sapiens	106-109
31864780-0	2020	Corrigendum to "Biochemical and Biophysical characterization of curcumin binding to human mitotic kinesin Eg5: Insights into the inhibitory mechanism of curcumin on Eg5" [Int.	Curcumin	64-72	kinesin family member 11	Homo sapiens	165-168
32673649-11	2020	Besides, curcumin restored NF-kappaB, IL-1, IL-10, TGF-beta, CTGF, Col-I, MMP-13, and Smad7 protein levels.	Curcumin	9-17	interleukin 10	Rattus norvegicus	44-49
32673649-11	2020	Besides, curcumin restored NF-kappaB, IL-1, IL-10, TGF-beta, CTGF, Col-I, MMP-13, and Smad7 protein levels.	Curcumin	9-17	cellular communication network factor 2	Rattus norvegicus	61-65
20405005-11	2010	Further, curcumin down-regulated the pro-survival protein Bcl-xL, depolarized the mitochondrial membrane, increased PARP cleavage, which led to apoptotic cell death.	Curcumin	9-17	BCL2-like 1	Mus musculus	58-64
32348213-4	2020	OBJECTIVE: To evaluate the effect of curcumin nanoemulsions prepared with lecithin modified with medium-chain fatty acids as an emulsifier, on the expression of the Cdk4, Ccne2, Casp8 and Cldn4 genes involved in the carcinogenesis process in K14E6 transgenic mice.	Curcumin	37-45	caspase 8	Mus musculus	178-183
20405005-12	2010	Finally, curcumin had a concentration-dependent suppressive effect on ACTH secretion from AtT20 cells.	Curcumin	9-17	pro-opiomelanocortin-alpha	Mus musculus	70-74
20125031-0	2010	Curcumin protects rat myocardium against isoproterenol-induced ischemic injury: attenuation of ventricular dysfunction through increased expression of Hsp27 along with strengthening antioxidant defense system.	Curcumin	0-8	heat shock protein family B (small) member 1	Rattus norvegicus	151-156
31801161-10	2020	Curcumin inhibited the expression of phosphorylated JNK and NF-kappaB proteins to block the RAGE/JNK/NF-kappaB signaling pathway.	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	52-55
31801161-10	2020	Curcumin inhibited the expression of phosphorylated JNK and NF-kappaB proteins to block the RAGE/JNK/NF-kappaB signaling pathway.	Curcumin	0-8	MOK protein kinase	Rattus norvegicus	92-96
31801161-10	2020	Curcumin inhibited the expression of phosphorylated JNK and NF-kappaB proteins to block the RAGE/JNK/NF-kappaB signaling pathway.	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	97-100
31801161-11	2020	In conclusion, these results indicate that curcumin blocks the phosphorylation of JNK and NF-kappaB protein to inhibit this signaling pathway, thereby further inhibiting inflammation and apoptosis in pancreatic islet beta cells.	Curcumin	43-51	mitogen-activated protein kinase 8	Rattus norvegicus	82-85
20569277-7	2010	Defining the mechanism(s) by which Grp94 exerts its antioxidant defence, the determination of cytosolic calcium levels in C2C12 cells by fura-2 showed a significantly reduced amount of releasable calcium from intracellular stores, both in conditions of Grp94 overexpression and after curcumin pre-treatment.	Curcumin	284-292	heat shock protein 90, beta (Grp94), member 1	Mus musculus	35-40
20569277-8	2010	Therefore, a brief exposure to curcumin induces a delayed cytoprotection against oxidative stress in myogenic cells by increasing Grp94 protein level, which acts as a regulator of calcium homeostasis.	Curcumin	31-39	heat shock protein 90, beta (Grp94), member 1	Mus musculus	130-135
20054649-4	2010	Curcumin supplementation to MNU treated mice was able to reduce significantly the activities of the G6P, G6I, hexokinase, LDH, SDH and increased the glycogen contents in both the regions of brain which were altered following MNU treatment.	Curcumin	0-8	glucose-6-phosphatase, catalytic	Mus musculus	100-103
31630418-7	2020	After blocking Act1/TRAF6/p38MAPK cascade and interfering AP-1 with Curcumin or c-Jun siRNA, CCL2 expression induced by IL-17 was significantly attenuated at both mRNA and protein levels.	Curcumin	68-76	C-C motif chemokine ligand 2	Homo sapiens	93-97
31862869-0	2019	Curcumin Alleviates Lipopolysaccharide (LPS)-Activated Neuroinflammation via Modulation of miR-199b-5p/IkappaB Kinase beta (IKKbeta)/Nuclear Factor Kappa B (NF-kappaB) Pathway in Microglia.	Curcumin	0-8	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	103-122
31862869-0	2019	Curcumin Alleviates Lipopolysaccharide (LPS)-Activated Neuroinflammation via Modulation of miR-199b-5p/IkappaB Kinase beta (IKKbeta)/Nuclear Factor Kappa B (NF-kappaB) Pathway in Microglia.	Curcumin	0-8	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	124-131
31817533-0	2019	Dietary Curcumin Supplementation Increases Antioxidant Capacity, Upregulates Nrf2 and Hmox1 Levels in the Liver of Piglet Model with Intrauterine Growth Retardation.	Curcumin	8-16	heme oxygenase 1	Homo sapiens	86-91
31817533-8	2019	Dietary curcumin supplementation increased body-weight gain, feed intake, activities of antioxidant enzymes, and the expressions of nuclear factor, erythroid 2-like 2 (Nrf2) and heme oxygenase-1 (Hmox1) proteins in the liver of weaned piglets with IUGR.	Curcumin	8-16	heme oxygenase 1	Homo sapiens	178-194
31817533-8	2019	Dietary curcumin supplementation increased body-weight gain, feed intake, activities of antioxidant enzymes, and the expressions of nuclear factor, erythroid 2-like 2 (Nrf2) and heme oxygenase-1 (Hmox1) proteins in the liver of weaned piglets with IUGR.	Curcumin	8-16	heme oxygenase 1	Homo sapiens	196-201
31817533-10	2019	Curcumin could efficiently improve the growth, increase hepatic antioxidant capacity, and upregulate Nrf2 and Hmox1 levels in the liver of IUGR weaned piglets.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	110-115
20071421-9	2010	Interestingly, the lead-induced upregulation of GRP78 and GRP94 was almost completely blocked by the JNK inhibitor SP600125 or activator protein-1 (AP-1) inhibitor curcumin.	Curcumin	164-172	heat shock protein family A (Hsp70) member 5	Bos taurus	48-53
31027431-6	2019	RESULTS: Our study showed that the chrysin-curcumin-loaded nanofibres have anti-inflammatory properties in several stages of the wound-healing process by affecting the IL-6, MMP-2, TIMP-1, TIMP-2 and iNOS gene expression.	Curcumin	43-51	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	189-195
31745802-10	2019	Oral administration of curcumin and taurine to BPA-exposed rats significantly reversed the content of lipid peroxidation products, as well as enhanced the activities of GPx and GST, CAT, and SOD enzymes.	Curcumin	23-31	hematopoietic prostaglandin D synthase	Rattus norvegicus	177-180
31741405-8	2019	Furthermore, curcumin upregulated the expression of E-cadherin and LC3 proteins and downregulated the vimentin, TWIST1, p62, p-mTOR, p-Akt and P13K levels in DN rats and MPC5 cells.	Curcumin	13-21	cadherin 1	Rattus norvegicus	52-62
20025076-6	2010	Furthermore, curcumin reduced the levels of beta-catenin, the activate/phosphorylated form of Akt and NF-kappaB, which led to downregulating the three common key effectors, namely C-myc, N-myc, and Cyclin D1.	Curcumin	13-21	cyclin D1	Homo sapiens	198-207
31819422-10	2019	In activated macrophages, N-PD decreased levels of pro-inflammatory cytokines, while N-CU increased levels of anti-inflammatory IL-10, and N-PD/CU exhibited best therapeutic effect in vitro, suggesting co-delivery of PD and CU may synergistically control the course of RA.	Curcumin	87-89	interleukin 10	Rattus norvegicus	128-133
31754130-0	2019	Regulation of carcinogenesis and modulation through Wnt/beta-catenin signaling by curcumin in an ovarian cancer cell line.	Curcumin	82-90	catenin beta 1	Homo sapiens	56-68
20127004-0	2010	Curcumin blocks migration and invasion of mouse-rat hybrid retina ganglion cells (N18) through the inhibition of MMP-2, -9, FAK, Rho A and Rock-1 gene expression.	Curcumin	0-8	matrix metallopeptidase 2	Rattus norvegicus	113-122
31754130-3	2019	In a compounds screening, we found that curcumin can inhibit Wnt/beta-catenin signaling.	Curcumin	40-48	catenin beta 1	Homo sapiens	65-77
31754130-6	2019	The results showed that curcumin combined with 5 muM DAC may inhibit cancer cell colony formation, migration through EMT (epithelial-mesenchymal transition) process regulation, total DNMT activity, especially in DNMT3a protein expression, and may also regulate tumor suppressor gene SFRP5 expression involved in the Wnt/beta-catenin signaling pathway.	Curcumin	24-32	DNA methyltransferase 3 alpha	Homo sapiens	212-218
20015472-6	2010	RESULTS: Dietary curcumin enhanced GSHT (p&lt;0.001) and UGT1A1 (p&lt;0.05) activity and significantly reduced the activity of CYP1A1 (p&lt;0.001), in rats exposed to aflatoxin B(1).	Curcumin	17-25	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	57-63
31752145-4	2019	In cancer cells, CN induced apoptosis and cell cycle arrest at G2/M phase through a p53-mediated mechanism, where p53 was activated, p21 and pro-apoptotic proteins Bid and Bak were upregulated, and PARP was cleaved.	Curcumin	17-19	H3 histone pseudogene 16	Homo sapiens	133-136
31752145-5	2019	In non-transformed human mammary epithelial cells MCF10A, CN at 50 microM had no cytotoxicity and p53 was not activated, but curcumin at 12.5 microM activated p53 and p21 and inhibited MCF10A cell growth.	Curcumin	125-133	H3 histone pseudogene 16	Homo sapiens	167-170
31788011-11	2019	Curcumin also markedly down-regulated the protein expression of hepatic TLR4 and myeloid differentiation factor 88 (MyD88), inhibited p65 nuclear translocation and DNA binding activity of nuclear factor-kappaB (NF-kappaB) in the liver.	Curcumin	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	134-137
20199731-8	2010	Immunohistochemistry results indicated that the positive expression of COX-2 in the curcumin intervention group was significantly lower than that in the NEC model group.	Curcumin	84-92	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	71-76
31798452-10	2019	Curcumin, flavocoxid and beta-caryophyllene suppressed IL-1beta expression with different IC50.	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	55-63
31717261-12	2019	Conversely, the expressions of superoxide dismutase 1 (SOD1) and SIRT1 were significantly upregulated by curcumin treatment.	Curcumin	105-113	sirtuin 1	Mus musculus	65-70
31698770-9	2019	However, co-administration of curcumin (200 mg/kg) with BaP markedly reduced CYP1A1 expression in a dose-dependent manner.	Curcumin	30-38	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	77-83
20199731-9	2010	CONCLUSIONS: Curcumin has protective effects against NEC in neonatal rats, possibly through inhibiting COX-2 expression, reducing TNF-alpha content, and increasing IL-10 content.	Curcumin	13-21	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	103-108
31432177-10	2019	These data suggested that curcumin may control the EGFR and TLR4/MyD88 pathways to synergistically downregulate downstream cell cycle- and EMT-related regulators, in order to block cell proliferation and metastasis in NSCLC.	Curcumin	26-34	toll like receptor 4	Homo sapiens	60-64
31436299-9	2019	The results demonstrated a significant decrease in EMT following exposure to 20 microM curcumin for 72 h. This finding was supported by a decrease in the protein expression levels of N-cadherin, Vimentin and Slug.	Curcumin	87-95	vimentin	Homo sapiens	195-203
31436300-4	2019	Treatment with curcumin decreased the WT1 levels in K562 cells, and also decreased CCNA1 protein expression.	Curcumin	15-23	cyclin A1	Homo sapiens	83-88
20686221-6	2010	In our study curcumin increased the expression of GADD45 and 153 in a p53-independent manner.	Curcumin	13-21	growth arrest and DNA damage inducible alpha	Homo sapiens	50-56
31595849-0	2019	Renoprotective effect of curcumin labelled on Mesoscale Nanoparticles (MNPs) on Renal Ischemia-Reperfusion Injury (RIRI) via the miR-146a/nNOS/NO/cGMP/PKG signaling pathway.	Curcumin	25-33	microRNA 146a	Homo sapiens	129-137
31595849-0	2019	Renoprotective effect of curcumin labelled on Mesoscale Nanoparticles (MNPs) on Renal Ischemia-Reperfusion Injury (RIRI) via the miR-146a/nNOS/NO/cGMP/PKG signaling pathway.	Curcumin	25-33	protein kinase cGMP-dependent 1	Homo sapiens	151-154
31468672-5	2019	The results reveal that curcumin possesses insignificant inhibitory activity against EV71 infection in RD cells [half-maximal effective concentration (EC50 ) &gt;200 microg mL-1 ] but exhibits high cytotoxicity toward RD cells (half-maximal cytotoxic concentration (CC50 ) &lt;13 microg mL-1 ).	Curcumin	24-32	L1 cell adhesion molecule	Mus musculus	173-177
31581661-9	2019	TGF-beta signaling, including the androgen/TGF-beta inhibitor Prostate transmembrane protein androgen-induced 1 (PMEPA1), was the only pathway impacted by curcumin treatment after 48 h. Our findings also established that MYC Proto-Oncogene, basic helix-loop-helix (bHLH) Transcription Factor (MYC) signaling was down-regulated in curcumin-treated cell lines.	Curcumin	155-163	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	221-224
20686221-8	2010	Treatment with GADD45 and 153 small interfering RNAs (siRNAs) inhibited the apoptotic induction in PC-9 cells by curcumin.	Curcumin	113-121	growth arrest and DNA damage inducible alpha	Homo sapiens	15-21
31581661-9	2019	TGF-beta signaling, including the androgen/TGF-beta inhibitor Prostate transmembrane protein androgen-induced 1 (PMEPA1), was the only pathway impacted by curcumin treatment after 48 h. Our findings also established that MYC Proto-Oncogene, basic helix-loop-helix (bHLH) Transcription Factor (MYC) signaling was down-regulated in curcumin-treated cell lines.	Curcumin	155-163	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	293-296
31468672-5	2019	The results reveal that curcumin possesses insignificant inhibitory activity against EV71 infection in RD cells [half-maximal effective concentration (EC50 ) &gt;200 microg mL-1 ] but exhibits high cytotoxicity toward RD cells (half-maximal cytotoxic concentration (CC50 ) &lt;13 microg mL-1 ).	Curcumin	24-32	L1 cell adhesion molecule	Mus musculus	287-291
31468672-6	2019	The EC50 (0.2 microg mL-1 ) and CC50 (452.2 microg mL-1 ) of Cur-CQDs are &gt;1000-fold lower and &gt;34-fold higher, respectively, than those of curcumin, demonstrating their far superior antiviral capabilities and high biocompatibility.	Curcumin	146-154	L1 cell adhesion molecule	Mus musculus	51-55
20686221-9	2010	Moreover, curcumin induced the expression of cyclin dependent kinase inhibitor genes p21 and p27, while it inhibited the expression of numerous genes, including Bcl-2, cyclin D1, CDK2, CDK4 and CDK6.	Curcumin	10-18	cyclin D1	Homo sapiens	168-177
31569380-10	2019	A non-cytotoxic dose of curcumin (15 microM) inhibited MCE, downregulated the expression of PPARgamma and C/EBPalpha, prevented differentiation medium-induced beta-catenin downregulation, and decreased the lipid accumulation in 3T3-L1 adipocytes.	Curcumin	24-32	catenin beta 1	Homo sapiens	159-171
31030375-10	2019	Curcumin or THC complexes in HP-CDs with improved bioavailability also induced anti-oxidant activity (SOD1, CAT1, and HMOX1) in higher levels in the ocular epithelial cells and showed oxidative protection effects in rabbit cornea tissues that will boost up their application in ocular medicine.	Curcumin	0-8	superoxide dismutase [Cu-Zn]	Oryctolagus cuniculus	102-106
20686221-9	2010	Moreover, curcumin induced the expression of cyclin dependent kinase inhibitor genes p21 and p27, while it inhibited the expression of numerous genes, including Bcl-2, cyclin D1, CDK2, CDK4 and CDK6.	Curcumin	10-18	cyclin dependent kinase 2	Homo sapiens	179-183
20686221-9	2010	Moreover, curcumin induced the expression of cyclin dependent kinase inhibitor genes p21 and p27, while it inhibited the expression of numerous genes, including Bcl-2, cyclin D1, CDK2, CDK4 and CDK6.	Curcumin	10-18	cyclin dependent kinase 4	Homo sapiens	185-189
31377611-0	2019	Mitochondrial targeting nano-curcumin for attenuation on PKM2 and FASN.	Curcumin	29-37	pyruvate kinase M1/2	Homo sapiens	57-61
20686221-10	2010	All the results with PC-9 cells suggest that the up-regulation of GADD45 and 153 by curcumin is a prime mechanism in the anticancer activity of curcumin.	Curcumin	84-92	growth arrest and DNA damage inducible alpha	Homo sapiens	66-72
31612395-3	2019	Our previous studies have shown that curcumin suppresses HSC activation through increasing peroxisome proliferator-activated receptor, gamma (PPARgamma) and 5" adenosine monophosphate-activated protein kinase (AMPK) activities.	Curcumin	37-45	fucosyltransferase 1 (H blood group)	Homo sapiens	57-60
31612395-5	2019	Now we showed that curcumin increased LD formation in activated HSCs and stimulated the expression of sterol regulatory element-binding protein and fatty acid synthase, and reduced the expression of adipose triglyceride lipase.	Curcumin	19-27	patatin like phospholipase domain containing 2	Homo sapiens	199-226
32802100-12	2019	Moreover, curcumin showed a potent attenuating effect on the number of Iba1 positive cells in rats which were subjected to morphine dependence.	Curcumin	10-18	allograft inflammatory factor 1	Rattus norvegicus	71-75
31554289-9	2019	Furthermore, dietary curcumin supplement linearly inhibited testicular apoptosis with increased testicular bcl-2 mRNA expression and decreased caspase-3 mRNA expression (p &lt; 0.05).	Curcumin	21-29	caspase-3	Ovis aries	143-152
20686221-10	2010	All the results with PC-9 cells suggest that the up-regulation of GADD45 and 153 by curcumin is a prime mechanism in the anticancer activity of curcumin.	Curcumin	144-152	growth arrest and DNA damage inducible alpha	Homo sapiens	66-72
31488728-5	2019	Curcumin treatment significantly increased the expression of Beclin1, Atg5, and Atg16L1, induced the formation of autophagosomes, and promoted autophagosome-lysosome fusion in N2a/APP695swe cells.	Curcumin	0-8	beclin 1, autophagy related	Mus musculus	61-68
31488728-7	2019	Moreover, curcumin also increased the expression of the scaffolding proteins Rab7- interacting lysosomal protein (RILP) and huntingtin in N2a/APP695swe cells.	Curcumin	10-18	huntingtin	Mus musculus	124-134
20015232-4	2010	Both EPCG and curcumin were able to attenuate QUIN-induced Ca(2+) influx and neuronal nitric oxide synthase (nNOS) activity to a greater extent compared with apigenin, naringenin and gallotannin.	Curcumin	14-22	nitric oxide synthase 1	Homo sapiens	77-107
31494752-7	2019	Based on this, a fluorometric assay with a detection limit of 21 ng mL-1 was developed for the determination of curcumin.	Curcumin	112-120	L1 cell adhesion molecule	Mus musculus	68-72
20015232-4	2010	Both EPCG and curcumin were able to attenuate QUIN-induced Ca(2+) influx and neuronal nitric oxide synthase (nNOS) activity to a greater extent compared with apigenin, naringenin and gallotannin.	Curcumin	14-22	nitric oxide synthase 1	Homo sapiens	109-113
20838026-1	2010	We performed this study to determine if curcumin affects pro-inflammatory responses to activation of proteinase-activated receptor-2 (PAR2) in human pulmonary adenocarcinoma A549 cells.	Curcumin	40-48	F2R like trypsin receptor 1	Homo sapiens	101-132
20838026-1	2010	We performed this study to determine if curcumin affects pro-inflammatory responses to activation of proteinase-activated receptor-2 (PAR2) in human pulmonary adenocarcinoma A549 cells.	Curcumin	40-48	F2R like trypsin receptor 1	Homo sapiens	134-138
20838026-2	2010	Curcumin completely inhibited the PAR2-triggered prostaglandin E(2) (PGE(2)) production, but notably not interleukin-8 release.	Curcumin	0-8	F2R like trypsin receptor 1	Homo sapiens	34-38
31261029-2	2019	A biocompatible grafting polymer-based thermal sensitive hybrid hydrogel (Chitosan-P123, CP) containing gelatin and curcumin was designed to be suitable stiffness for tissue regeneration.	Curcumin	116-124	ceruloplasmin	Homo sapiens	89-91
20838026-3	2010	Cyclooxygenase-2 (COX-2) upregulation, but not its upstream activation of mitogen-activated protein kinases, caused by PAR2 stimulation was partially inhibited by curcumin.	Curcumin	163-171	F2R like trypsin receptor 1	Homo sapiens	119-123
31261029-4	2019	Especial, the thermally induced phase transition of CP hydrogel was governed by the participant of gelatin rather than curcumin.	Curcumin	119-127	ceruloplasmin	Homo sapiens	52-54
20838026-4	2010	Curcumin inhibited the PAR2-triggered phosphorylation of I-kappaB, an indicator for nuclear factor-kappaB (NF-kappaB) activation, and also its upstream signal Akt, which is known to contribute to PAR2-triggered PGE(2) formation, but not COX-2 upregulation.	Curcumin	0-8	F2R like trypsin receptor 1	Homo sapiens	23-27
20838026-4	2010	Curcumin inhibited the PAR2-triggered phosphorylation of I-kappaB, an indicator for nuclear factor-kappaB (NF-kappaB) activation, and also its upstream signal Akt, which is known to contribute to PAR2-triggered PGE(2) formation, but not COX-2 upregulation.	Curcumin	0-8	F2R like trypsin receptor 1	Homo sapiens	196-200
20838026-5	2010	Collectively, curcumin inhibits the PAR2-triggered PGE(2) production by suppressing COX-2 upregulation and Akt/NF-kappaB signals in A549 cells.	Curcumin	14-22	F2R like trypsin receptor 1	Homo sapiens	36-40
31592057-3	2019	In this study, we found that curcumin or heat shock treatment up-regulated the expression of adipose triglyceride lipase (ATGL) in Huh7 hepatoma cells, which resulted in acceleration of lipolysis.	Curcumin	29-37	patatin like phospholipase domain containing 2	Homo sapiens	93-120
31592057-3	2019	In this study, we found that curcumin or heat shock treatment up-regulated the expression of adipose triglyceride lipase (ATGL) in Huh7 hepatoma cells, which resulted in acceleration of lipolysis.	Curcumin	29-37	patatin like phospholipase domain containing 2	Homo sapiens	122-126
20661831-5	2010	Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak).	Curcumin	15-23	caspase 8	Homo sapiens	101-110
31592057-9	2019	To support this notion, the cytotoxicity of curcumin was aggravated in ATGL-knockdown cells.	Curcumin	44-52	patatin like phospholipase domain containing 2	Homo sapiens	71-75
20661831-7	2010	Caspase-8 inhibition abrogated Bid cleavage and strongly reduced caspase-9 activation, suggesting that the cross-talk mechanism mediated by caspase-8-dependent Bid cleavage can contribute to the activation of the intrinsic apoptotic pathway by curcumin + carnosic acid.	Curcumin	244-252	caspase 8	Homo sapiens	0-9
31592057-10	2019	Curcumin decreased intracellular ATP for activating AMP-activated protein kinase, which initiates catabolic pathways including ATGL-dependent lipolysis.	Curcumin	0-8	patatin like phospholipase domain containing 2	Homo sapiens	127-131
31480578-5	2019	The Curcumin ASD demonstrated enhanced bioavailability by 11-fold and improved anti-inflammatory activities by the decrease in cytokine production (MMP-9, IL-1beta, IL-6, VEGF, MIP-2, and TNF-alpha) compared to the raw Curcumin.	Curcumin	4-12	C-X-C motif chemokine ligand 2	Homo sapiens	177-182
20661831-7	2010	Caspase-8 inhibition abrogated Bid cleavage and strongly reduced caspase-9 activation, suggesting that the cross-talk mechanism mediated by caspase-8-dependent Bid cleavage can contribute to the activation of the intrinsic apoptotic pathway by curcumin + carnosic acid.	Curcumin	244-252	caspase 8	Homo sapiens	140-149
19956394-6	2009	Treatment of FOLFOX-surviving colon cancer cells with either curcumin alone or together with FOLFOX resulted in a marked reduction in CSCs, as evidenced by the decreased expression of CD44 and CD166 as well as EGFR and by their ability to form anchorage-dependent colonies.	Curcumin	61-69	activated leukocyte cell adhesion molecule	Homo sapiens	193-198
19477063-0	2009	Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF).	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	103-136
31894682-9	2019	Compared with the BDL group, the serum levels of ALT and AST in the curcumin treatment group were decreased significantly (P&lt;0.05), collagen deposition and inflammatory cell infiltration were improved, and HO-1 expression was increased (P&lt;0.05) after curcumin treatement.	Curcumin	68-76	glutamic pyruvic transaminase, soluble	Mus musculus	49-52
19623659-0	2009	Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.	Curcumin	0-8	cyclin D1	Homo sapiens	77-86
31894682-9	2019	Compared with the BDL group, the serum levels of ALT and AST in the curcumin treatment group were decreased significantly (P&lt;0.05), collagen deposition and inflammatory cell infiltration were improved, and HO-1 expression was increased (P&lt;0.05) after curcumin treatement.	Curcumin	68-76	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	57-60
19623659-6	2009	In nude mice, the combination of curcumin and capecitabine was found to be more effective than either agent alone in reducing tumor volume (p = 0.001 vs. control; p = 0.031 vs. capecitabine alone), Ki-67 proliferation index (p = 0.001 vs. control) and microvessel density marker CD31.	Curcumin	33-41	platelet/endothelial cell adhesion molecule 1	Mus musculus	279-283
31432995-2	2019	METHODS: The rats underwent ACLT and received 50mul of curcumin at the concentration of 1 mg mL-1 and 10 mug LPS by intra-articular injection once a week for 8 weeks.	Curcumin	55-63	L1 cell adhesion molecule	Mus musculus	93-104
19736547-0	2009	Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1.	Curcumin	0-8	oxidized low density lipoprotein receptor 1	Homo sapiens	110-145
19736547-7	2009	Curcumin suppresses gene expression of lectin-like oxidized LDL receptor-1 (LOX-1), leading to the blockade of the transport of extracellular ox-LDL into cells.	Curcumin	0-8	oxidized low density lipoprotein receptor 1	Homo sapiens	39-74
19736547-7	2009	Curcumin suppresses gene expression of lectin-like oxidized LDL receptor-1 (LOX-1), leading to the blockade of the transport of extracellular ox-LDL into cells.	Curcumin	0-8	oxidized low density lipoprotein receptor 1	Homo sapiens	76-81
30498979-10	2019	RESULTS: Curcumin and piperine increased the TGF-beta level, significantly improved the collagen repair, and decreased the cellularity and activation of NF-kB in the periodontal tissues, but only curcumin caused a significant increase in early bone repair.	Curcumin	9-17	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	153-158
31466778-0	2019	Effect of curcumin supplementation on TLR4 mediated non-specific immune responses in liver of laying hens under high-temperature conditions.	Curcumin	10-18	toll like receptor 4	Gallus gallus	38-42
19736547-9	2009	In conclusion, these results support our initial hypothesis and demonstrate that ox-LDL stimulates HSC activation, which is eliminated by curcumin by suppressing lox-1 expression by interrupting Wnt signaling and stimulating PPARgamma activity.	Curcumin	138-146	oxidized low density lipoprotein receptor 1	Homo sapiens	162-167
31466778-5	2019	Thus, this study aimed to investigate the effect of curcumin supplementation on TLR4 mediated non-specific immune response in liver of laying hens under high-temperature conditions.	Curcumin	52-60	toll like receptor 4	Gallus gallus	80-84
19958643-0	2009	[Curcumine inhibits migration and invasion of hepatic stellate cells by reducing MMP-2 expression and activity].	Curcumin	1-10	matrix metallopeptidase 2	Rattus norvegicus	81-86
31466778-8	2019	The results of present study showed that heat stress curcumin treatment group had reduced inflammatory responses (IL-6, IL-1beta, TNF-alpha) as compared to HC and NC group.	Curcumin	53-61	interleukin 1, beta	Gallus gallus	120-128
31466778-10	2019	Furthermore, PCNA, TLR4 and its downstream gene expression as well as protein expression (TLR4, NF-kappaB and PCNA) were significantly down regulated in heat stress curcumin supplemented group as compared to HC and NC group.	Curcumin	165-173	toll like receptor 4	Gallus gallus	19-23
19958643-5	2009	RESULTS: Curcumine reduced the level and activity of MMP-2 expression in activated HSC in a dose-dependent manner.	Curcumin	9-18	matrix metallopeptidase 2	Rattus norvegicus	53-58
31257466-10	2019	The expression levels of NICD, hairy and enhancer of split (Hes)-1, Hes-5 and hairy/enhancer-of-split related with YRPW motif protein 1 (Hey-1) were significantly decreased in H/R-treated cells following curcumin treatment.	Curcumin	204-212	hes family bHLH transcription factor 1	Rattus norvegicus	31-66
19958643-6	2009	When treated with 25, 50 or 100 micromol/L curcumine, the expression of MMP-2 was reduced by 21.8%+/-5.1%, 65.5%+/-9.2% or 87.9%+/-11.5% (P &lt; 0.05), and the activity of MMP-2 was also significantly reduced by curcumine.	Curcumin	43-52	matrix metallopeptidase 2	Rattus norvegicus	72-77
19958643-6	2009	When treated with 25, 50 or 100 micromol/L curcumine, the expression of MMP-2 was reduced by 21.8%+/-5.1%, 65.5%+/-9.2% or 87.9%+/-11.5% (P &lt; 0.05), and the activity of MMP-2 was also significantly reduced by curcumine.	Curcumin	43-52	matrix metallopeptidase 2	Rattus norvegicus	172-177
19665995-0	2009	Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	19-23
31366901-4	2019	The main aim of this study is to develop curcumin-loaded solid nanoparticles (Cur-SLN) in order to increase curcumin bioavailability and to evaluate their radiosensitizing ability in comparison to free curcumin (free-Cur), by using an in vitro approach on BC cell lines.	Curcumin	41-49	sarcolipin	Homo sapiens	82-85
31366901-4	2019	The main aim of this study is to develop curcumin-loaded solid nanoparticles (Cur-SLN) in order to increase curcumin bioavailability and to evaluate their radiosensitizing ability in comparison to free curcumin (free-Cur), by using an in vitro approach on BC cell lines.	Curcumin	108-116	sarcolipin	Homo sapiens	82-85
19288529-3	2009	The results were as follows: (1) genistein and curcumin inhibited the production of MUC5AC mucin protein induced by EGF, dose-dependently; (2) genistein and curcumin also inhibited the expression of MUC5AC mucin gene induced by EGF.	Curcumin	47-55	LOC100508689	Homo sapiens	206-211
31366901-4	2019	The main aim of this study is to develop curcumin-loaded solid nanoparticles (Cur-SLN) in order to increase curcumin bioavailability and to evaluate their radiosensitizing ability in comparison to free curcumin (free-Cur), by using an in vitro approach on BC cell lines.	Curcumin	108-116	sarcolipin	Homo sapiens	82-85
31295875-9	2019	The data indicate that curcumin modulates autophagy by classic signaling pathways (suppression of protein kinase B (Akt)/mammalian target of rapamycin (mTOR) and/or by stimulation of adenosine monophosphate-activated protein kinase (AMPK) and extracellular signal-dependent kinase (ERK) pathways).	Curcumin	23-31	protein tyrosine kinase 2 beta	Homo sapiens	98-114
19288529-3	2009	The results were as follows: (1) genistein and curcumin inhibited the production of MUC5AC mucin protein induced by EGF, dose-dependently; (2) genistein and curcumin also inhibited the expression of MUC5AC mucin gene induced by EGF.	Curcumin	157-165	LOC100508689	Homo sapiens	91-96
19288529-3	2009	The results were as follows: (1) genistein and curcumin inhibited the production of MUC5AC mucin protein induced by EGF, dose-dependently; (2) genistein and curcumin also inhibited the expression of MUC5AC mucin gene induced by EGF.	Curcumin	157-165	LOC100508689	Homo sapiens	206-211
19288529-4	2009	This result suggests that genistein and curcumin can regulate mucin gene expression and production of mucin protein induced by EGF, by directly acting on airway epithelial cells.	Curcumin	40-48	LOC100508689	Homo sapiens	62-67
31184357-1	2019	We report a one-step emulsification and rapid freeze-drying process to develop a curcumin-ionic liquid (CCM-IL) complex that could be readily dispersed in water with a significantly enhanced solubility of ~8 mg mL-1 and half-life (t1/2) of ~260 min compared with free CCM (solubility ~30 nM and t1/2 ~ 20 min).	Curcumin	81-89	L1 cell adhesion molecule	Mus musculus	211-215
19288529-4	2009	This result suggests that genistein and curcumin can regulate mucin gene expression and production of mucin protein induced by EGF, by directly acting on airway epithelial cells.	Curcumin	40-48	LOC100508689	Homo sapiens	102-107
19303754-9	2009	Western blotting analysis showed that curcumin inhibited TLR ligands and anti-IgM-induced phosphorylation of ERK, IkappaB and p38.	Curcumin	38-46	mitogen-activated protein kinase 14	Mus musculus	126-129
31359699-3	2019	Due to the poor stability,low solubility,poor absorption and low bioavailability of curcumin,N-acetyl-L-cysteine( NAC) was used as an absorption enhancer and mixed with curcumin to improve the absorption of curcumin in the body.	Curcumin	84-92	synuclein alpha	Homo sapiens	114-117
31359699-3	2019	Due to the poor stability,low solubility,poor absorption and low bioavailability of curcumin,N-acetyl-L-cysteine( NAC) was used as an absorption enhancer and mixed with curcumin to improve the absorption of curcumin in the body.	Curcumin	169-177	synuclein alpha	Homo sapiens	114-117
19860939-9	2009	Using immunohistochemistry, we demonstrated a decrease in the expression of Cox-2 by 8% and Cyclin D1 by 13% in the animals treated with curcumin; both genes regulated by NF-kappaB and related to cell proliferation.	Curcumin	137-145	cytochrome c oxidase II, mitochondrial	Mus musculus	76-81
31359699-3	2019	Due to the poor stability,low solubility,poor absorption and low bioavailability of curcumin,N-acetyl-L-cysteine( NAC) was used as an absorption enhancer and mixed with curcumin to improve the absorption of curcumin in the body.	Curcumin	169-177	synuclein alpha	Homo sapiens	114-117
31602860-0	2019	[Curcumin inhibits proliferation,migration and invasion of gastric cancer cells via Wnt3a/beta-catenin/EMT signaling pathway].	Curcumin	1-9	catenin beta 1	Homo sapiens	90-102
31602860-0	2019	[Curcumin inhibits proliferation,migration and invasion of gastric cancer cells via Wnt3a/beta-catenin/EMT signaling pathway].	Curcumin	1-9	IL2 inducible T cell kinase	Homo sapiens	103-106
31602860-7	2019	Moreover,curcumin could inhibit the migration and invasion of MKN45 cells,downregulate the expression of N-cadherin,snail1,Wnt3 a,p-beta-catenin,p-LRP6 and Bcl-2,and upregulate the expression of E-cadherin and Bax,it could increase the activity of caspase-3,caspase-8,caspase-9 and induce apoptosis as well.	Curcumin	9-17	catenin beta 1	Homo sapiens	132-144
31602860-7	2019	Moreover,curcumin could inhibit the migration and invasion of MKN45 cells,downregulate the expression of N-cadherin,snail1,Wnt3 a,p-beta-catenin,p-LRP6 and Bcl-2,and upregulate the expression of E-cadherin and Bax,it could increase the activity of caspase-3,caspase-8,caspase-9 and induce apoptosis as well.	Curcumin	9-17	caspase 9	Homo sapiens	268-277
31252572-5	2019	The present experiments show that the administration of curcumin is able to increase the production of the anti-inflammatory cytokines, IL-4 and IL-10, in murine BV-2 microglial cells treated with lipopolysaccharide (LPS).	Curcumin	56-64	interleukin 4	Mus musculus	136-140
19956448-8	2009	Treatment with curcumin led to a dose-dependent decrease in the expression of NICD associated with the induction of cleaved poly ADP-ribose polymerase (PARP), the degradation of cyclin D1 and increase in cyclin-dependent kinase p21.	Curcumin	15-23	cyclin D1	Homo sapiens	178-187
19246153-2	2009	Here we show that the natural compound curcumin induces nuclear translocation of the heat shock transcription factor (HSF)-1, its binding to a heat shock regulatory element (HSE), and the subsequent activation of the hsp70 promoter through the extracellular regulated kinase (ERK)/mitogen activated protein (MAP) ERK (MEK) and c-jun N-terminal kinase (JNK) pathways, but not through p38.	Curcumin	39-47	heat shock transcription factor 1	Homo sapiens	85-124
31135130-0	2019	Correction to Curcumin-Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer"s Disease Model via Canonical Wnt/beta-Catenin Pathway.	Curcumin	14-22	catenin beta 1	Homo sapiens	157-169
31085592-6	2019	In vivo studies showed that ER-targeting curcumin-loaded PLGA NPs treatment enhanced neutrophil gp91phox expression, ROS production and peritoneal bacterial clearance ability of the CybbC1024T transgenic Cybb -/- mice.	Curcumin	41-49	paired Ig-like receptor B	Mus musculus	96-100
19246153-3	2009	We observe that curcumin activates hsp70A and hsp70B mRNA transcription, increases HSP protein expression but decreases the expression of Bag-1, a Hsp70 co-chaperone in K562 cells.	Curcumin	16-24	heat shock protein family A (Hsp70) member 7 (pseudogene)	Homo sapiens	46-52
19513510-11	2009	Curcumin induced apoptosis through the intrinsic pathway and caspase-3-dependent and -independent pathways in N18 cells.	Curcumin	0-8	caspase 3	Rattus norvegicus	61-70
31249528-8	2019	Conclusions: Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR.	Curcumin	41-49	leptin	Homo sapiens	186-192
31244665-0	2019	Curcumin/Liposome Nanotechnology as Delivery Platform for Anti-inflammatory Activities via NFkB/ERK/pERK Pathway in Human Dental Pulp Treated With 2-HydroxyEthyl MethAcrylate (HEMA).	Curcumin	0-8	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	100-104
31009237-0	2019	Curcumin-Synthetic Analogs Library Screening by Docking and Quantitative Structure-Activity Relationship Studies for AXL Tyrosine Kinase Inhibition in Cancers.	Curcumin	0-8	AXL receptor tyrosine kinase	Homo sapiens	117-120
31009237-2	2019	Two-dimensional quantitative structure-activity relationship (2D-QSAR) tests were performed to elucidate a relationship between molecular structures and the activity of a series of 400 curcumin derivatives subjected to AXL kinase by ATP competition in the catalytic site.	Curcumin	185-193	AXL receptor tyrosine kinase	Homo sapiens	219-222
31009237-5	2019	Docking analysis reveled that three curcumin derivatives have the best affinity for AXL and formed a hydrogen bond with the important amino acid residues in the binding pocket.	Curcumin	36-44	AXL receptor tyrosine kinase	Homo sapiens	84-87
31326581-5	2019	After exposure of colorectal cancer cells with (i) miR-145 and (ii) curcumin-loaded Pr NCs, a strong increase in the intracellular levels of miR-145, which translated into a decreased cell proliferation rate and migration capacity of the treated cells, was observed.	Curcumin	68-76	microRNA 145	Homo sapiens	141-148
31042325-4	2019	In the present study, we showed that curcumin altered the expression of cell cycle-related genes (cyclin D1, PCNA, and p21) and inhibited the proliferation of prostate cancer cells.	Curcumin	37-45	proliferating cell nuclear antigen	Homo sapiens	109-113
31042325-5	2019	Furthermore, we found that curcumin significantly upregulated the expression of miR-34a, along with the downregulated expression of beta-catenin and c-myc in three prostate cancer cell lines.	Curcumin	27-35	catenin beta 1	Homo sapiens	132-144
31006841-0	2019	Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells.	Curcumin	0-8	ribosomal protein S6 kinase B1	Homo sapiens	86-92
31006841-12	2019	CONCLUSIONS: Curcumin can induce protective autophagy of human ovarian cancer cells by inhibiting the AKT/mTOR/p70S6K pathway, indicating the synergistic effects of curcumin and autophagy inhibition as a possible strategy to overcome the limits of current therapies in the eradication of epithelial ovarian cancer.	Curcumin	13-21	ribosomal protein S6 kinase B1	Homo sapiens	111-117
31042325-5	2019	Furthermore, we found that curcumin significantly upregulated the expression of miR-34a, along with the downregulated expression of beta-catenin and c-myc in three prostate cancer cell lines.	Curcumin	27-35	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	149-154
19191010-7	2009	Curcumin acts as an anti-inflammatory and anti-proliferative agent by causing down regulation of COX-2, iNOS and cyclin D1 in all the three cell lines but to different extent.	Curcumin	0-8	cyclin D1	Homo sapiens	113-122
19368804-6	2009	Further examination of the B16F10 cells showed that curcumin effectively suppresses Cyclin D1, P-NF-kB, BclXL, P-Akt, and VEGF, which explains its efficacy in blocking proliferation, survival, and invasion of the B16F10 cells in the brain.	Curcumin	52-60	BCL2-like 1	Mus musculus	104-109
31472681-12	2019	Curcumin (20 muM) significantly suppressed PA- or TG-induced decrease in cell viability, caspase 3 activity, and the expression levels of BAX, CHOP, and GRP78.	Curcumin	0-8	DNA-damage inducible transcript 3	Mus musculus	143-147
30993920-12	2019	HFD+curcumin+capsaicin caused decreased BAX, caspase-3, TOS, and ROS levels as compared to HFD, but increased TAS and Bcl-2.	Curcumin	4-12	BCL2 associated X, apoptosis regulator	Rattus norvegicus	40-43
31145652-8	2019	As Notch activity was blocked by the DAPT, the related proteins were downregulated, and the initiating cell proliferation of curcumin was abolished.	Curcumin	125-133	notch 1	Mus musculus	3-8
31145652-9	2019	These results might suggest that the function of curcumin was dependent on Notch signaling pathway.	Curcumin	49-57	notch 1	Mus musculus	75-80
30935902-6	2019	The inhibitory effect of curcumin, piperine and vitamin E on cell proliferation involves different markers, and in particular inhibits beta-catenin, cyclinD1 and p53, making them candidates for a possible use in alternative therapies although further studies are needed.	Curcumin	25-33	catenin beta 1	Homo sapiens	135-147
31223428-0	2019	Curcumin Inhibits the PERK-eIF2alpha-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model.	Curcumin	0-8	DNA-damage inducible transcript 3	Rattus norvegicus	37-41
31223428-5	2019	Curcumin inhibited the expression of cleaved caspase3, cleaved poly (ADP-ribose) polymerase (PARP), C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the chondroprotective protein Bcl2 in TBHP-treated chondrocytes.	Curcumin	0-8	poly (ADP-ribose) polymerase 1	Rattus norvegicus	63-91
31223428-5	2019	Curcumin inhibited the expression of cleaved caspase3, cleaved poly (ADP-ribose) polymerase (PARP), C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the chondroprotective protein Bcl2 in TBHP-treated chondrocytes.	Curcumin	0-8	DNA-damage inducible transcript 3	Rattus norvegicus	100-124
31223428-5	2019	Curcumin inhibited the expression of cleaved caspase3, cleaved poly (ADP-ribose) polymerase (PARP), C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the chondroprotective protein Bcl2 in TBHP-treated chondrocytes.	Curcumin	0-8	DNA-damage inducible transcript 3	Rattus norvegicus	126-130
31223428-8	2019	By applying immunohistochemical analysis, we found that curcumin enhanced the expression of SIRT1 and inhibited the expression of CHOP and cleaved caspase3 in ACLT rats.	Curcumin	56-64	DNA-damage inducible transcript 3	Rattus norvegicus	130-134
30900133-5	2019	To address this issue, tetrahydrocurcumin (THC), a colorless derivative of curcumin, was subjected to in silico screening (molecular docking and dynamics simulation studies) using homology model of gp120-CD4 binding.	Curcumin	33-41	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	198-203
30770549-0	2019	Curcumin prevents high glucose damage in retinal pigment epithelial cells through ERK1/2-mediated activation of the Nrf2/HO-1 pathway.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	121-125
30770549-5	2019	Further, curcumin was able to induce HO-1 expression via Nrf2 activation and counteracts the damage elicited by HG.	Curcumin	9-17	heme oxygenase 1	Homo sapiens	37-41
31223428-9	2019	Taken together, our present findings firstly indicate that curcumin could inhibit the PERK-eIF2alpha-CHOP axis of the ER stress response through the activation of SIRT1 in tert-Butyl hydroperoxide- (TBHP-) treated rat chondrocytes and ameliorated osteoarthritis development in vivo.	Curcumin	59-67	DNA-damage inducible transcript 3	Rattus norvegicus	101-105
30770549-6	2019	The present study demonstrated that curcumin provides protection against HG-induced damage in RPE cells through the activation of Nrf2/HO-1 signaling that involves the ERK pathway, suggesting that curcumin may have therapeutic value in the treatment of diabetic retinopathy.	Curcumin	36-44	heme oxygenase 1	Homo sapiens	135-139
19233493-7	2009	The p300-HAT inhibitory effects of curcumin have been demonstrated to ameliorate the development of cardiac hypertrophy and heart failure in animal models.	Curcumin	35-43	E1A binding protein p300	Homo sapiens	4-8
30770549-6	2019	The present study demonstrated that curcumin provides protection against HG-induced damage in RPE cells through the activation of Nrf2/HO-1 signaling that involves the ERK pathway, suggesting that curcumin may have therapeutic value in the treatment of diabetic retinopathy.	Curcumin	197-205	heme oxygenase 1	Homo sapiens	135-139
31392057-0	2019	A combined treatment of curcumin, piperine, and taurine alters the circulating levels of IL-10 and miR-21 in hepatocellular carcinoma patients: a pilot study.	Curcumin	24-32	microRNA 21	Homo sapiens	99-105
30964656-11	2019	Baicalein, curcumin, and rifampicin showed concentration-dependent inhibition of the alpha-synuclein aggregation and the IC50 (the concentration of the compound at which the maxiumum intensity was reduced by one-half) were calculated.	Curcumin	11-19	synuclein alpha	Homo sapiens	85-100
31223280-7	2019	The anticancer effects of curcumin are mainly mediated through its regulation of multiple cellular signaling pathways, including Wnt/beta-catenin, PI3K/Akt, JAK/STAT, MAPK, p53 and NF-kB signaling pathways.	Curcumin	26-34	catenin beta 1	Homo sapiens	133-145
30988750-9	2019	The artery blood PaCO2, serum Smad4, Smurf2 and IL-4 in the curcumin group were significantly lower on day 1 than those on day 5 (P&lt;0.05).	Curcumin	60-68	SMAD family member 4	Rattus norvegicus	30-35
31466778-10	2019	Furthermore, PCNA, TLR4 and its downstream gene expression as well as protein expression (TLR4, NF-kappaB and PCNA) were significantly down regulated in heat stress curcumin supplemented group as compared to HC and NC group.	Curcumin	165-173	toll like receptor 4	Gallus gallus	90-94
19288022-10	2009	Our results also show that curcumin inhibits the migratory activity of MDA-MB-231 cells through down-regulating the protein expression of NF-kappaBp65.	Curcumin	27-35	RELA proto-oncogene, NF-kB subunit	Homo sapiens	138-150
19101502-6	2009	Moreover, curcumin abrogated the increment of phospho-ERK1/2 and nuclear accumulation of ERK1/2 in primary rat VSMCs induced by Chol:MbetaCD, which led to a suppression of AP-1 promoter activity stimulated by Chol:MbetaCD.	Curcumin	10-18	mitogen activated protein kinase 3	Rattus norvegicus	54-60
30943761-10	2019	Resveratrol and curcumin reversed the H-89-induced spatial memory acquisition and retention impairments with significant increases in both CREB and pCREB proteins expressions compared to H-89-treated animals.	Curcumin	16-24	cAMP responsive element binding protein 1	Rattus norvegicus	139-143
19101502-6	2009	Moreover, curcumin abrogated the increment of phospho-ERK1/2 and nuclear accumulation of ERK1/2 in primary rat VSMCs induced by Chol:MbetaCD, which led to a suppression of AP-1 promoter activity stimulated by Chol:MbetaCD.	Curcumin	10-18	mitogen activated protein kinase 3	Rattus norvegicus	89-95
18976114-6	2009	In the rat model, diabetes caused a significant increase in blood levels of IL-6, MCP-1, TNF-alpha, glucose, HbA(1), and oxidative stress, which was significantly decreased in curcumin-supplemented rats.	Curcumin	176-184	hemoglobin alpha, adult chain 1	Rattus norvegicus	109-114
19176385-3	2009	Recently, we have shown that curcumin inhibits phosphorylation of p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), two downstream effector molecules of the mammalian target of rapamycin complex 1 (mTORC1) in numerous cancer cell lines.	Curcumin	29-37	eukaryotic translation initiation factor 4E	Homo sapiens	93-124
31737231-10	2019	NOX5 gene expression in curcumin 2.50 mM was higher than 5.00 mM group.	Curcumin	24-32	NADPH oxidase 5	Canis lupus familiaris	0-4
31737231-11	2019	In conclusion, curcumin seems to emolliate sperm parameters and to protect sperm against sperm reactive oxygen stress and increases NOX5 gene expression.	Curcumin	15-23	NADPH oxidase 5	Canis lupus familiaris	132-136
31252572-6	2019	Consistent with these data, curcumin stimulation upregulates the expression of Suppressors of cytokine signaling (SOCS)-1, whereas phosphorylation of the JAK2 and STAT3 was reduced.	Curcumin	28-36	Janus kinase 2	Mus musculus	154-158
30515807-0	2019	Curcumin and a hemi-analogue with improved blood-brain barrier permeability protect against amyloid-beta toxicity in Caenorhabditis elegans via SKN-1/Nrf activation.	Curcumin	0-8	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	144-149
19176385-3	2009	Recently, we have shown that curcumin inhibits phosphorylation of p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), two downstream effector molecules of the mammalian target of rapamycin complex 1 (mTORC1) in numerous cancer cell lines.	Curcumin	29-37	CREB regulated transcription coactivator 1	Mus musculus	243-249
31169275-8	2019	Our data pointed out, for the first time, that several genes involved in the modulation of apoptosis, including PMAIP1, BID, ZMAT3, CASP3, CASP7, and FAS, represent new targets of both singular and combinatorial treatments with resveratrol and curcumin, and also the combinatorial approach of curcumin and resveratrol exhibits a more powerful gene regulating effect compared to single treatment.	Curcumin	244-252	zinc finger matrin-type 3	Homo sapiens	125-130
19176385-5	2009	We observed that curcumin inhibited mTORC1 signaling not by inhibition of the upstream kinases, such as insulin-like growth factor 1 receptor (IGF-IR) and phosphoinositide-dependent kinase 1 (PDK1).	Curcumin	17-25	CREB regulated transcription coactivator 1	Mus musculus	36-42
31169275-8	2019	Our data pointed out, for the first time, that several genes involved in the modulation of apoptosis, including PMAIP1, BID, ZMAT3, CASP3, CASP7, and FAS, represent new targets of both singular and combinatorial treatments with resveratrol and curcumin, and also the combinatorial approach of curcumin and resveratrol exhibits a more powerful gene regulating effect compared to single treatment.	Curcumin	244-252	caspase 7	Homo sapiens	139-144
19176385-6	2009	Further, we found that curcumin inhibited mTORC1 signaling independently of protein phosphatase 2A (PP2A) or AMP-activated protein kinase AMPK-tuberous sclerosis complex (TSC).	Curcumin	23-31	CREB regulated transcription coactivator 1	Mus musculus	42-48
31169275-8	2019	Our data pointed out, for the first time, that several genes involved in the modulation of apoptosis, including PMAIP1, BID, ZMAT3, CASP3, CASP7, and FAS, represent new targets of both singular and combinatorial treatments with resveratrol and curcumin, and also the combinatorial approach of curcumin and resveratrol exhibits a more powerful gene regulating effect compared to single treatment.	Curcumin	293-301	zinc finger matrin-type 3	Homo sapiens	125-130
31169275-8	2019	Our data pointed out, for the first time, that several genes involved in the modulation of apoptosis, including PMAIP1, BID, ZMAT3, CASP3, CASP7, and FAS, represent new targets of both singular and combinatorial treatments with resveratrol and curcumin, and also the combinatorial approach of curcumin and resveratrol exhibits a more powerful gene regulating effect compared to single treatment.	Curcumin	293-301	caspase 7	Homo sapiens	139-144
19176385-7	2009	This is evidenced by the findings that curcumin was able to inhibit phosphorylation of S6K1 and 4E-BP1 in the cells pretreated with PP2A inhibitor (okadaic acid) or AMPK inhibitor (compound C), or in the cells expressing dominant-negative (dn) PP2A, shRNA to PP2A-A subunit, or dn-AMPKalpha.	Curcumin	39-47	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	165-169
31196210-8	2019	Combination treatment with curcumin and gefitinib markedly downregulated EGFR activity through suppressing Sp1 and blocking interaction of Sp1 and HADC1, and markedly suppressed receptor tyrosine kinases as well as ERK/MEK and AKT/S6K pathways in the resistant NSCLC cells.	Curcumin	27-35	EPH receptor B2	Homo sapiens	215-218
19176385-10	2009	Finally, we identified that curcumin was able to dissociate raptor from mTOR, leading to inhibition of mTORC1 activity.	Curcumin	28-36	CREB regulated transcription coactivator 1	Mus musculus	103-109
19374255-0	2009	Curcumin arrests endometriosis by downregulation of matrix metalloproteinase-9 activity.	Curcumin	0-8	matrix metallopeptidase 9	Mus musculus	52-78
28963442-7	2019	In addition, curcumin effectively reduced acrylamide-induced HepG2 cell proliferation and induced apoptosis through the expression of miR-21.	Curcumin	13-21	microRNA 21	Homo sapiens	134-140
19374255-6	2009	Results showed that MMP-9 activity increased gradually in endometriotic tissues with severity and curcumin treatment reversed the MMP-9 activity near to control value.	Curcumin	98-106	matrix metallopeptidase 9	Mus musculus	20-25
30918132-0	2019	Curcumin Ameliorates Chronic Renal Failure in 5/6 Nephrectomized Rats by Regulation of the mTOR/HIF-1alpha/VEGF Signaling Pathway.	Curcumin	0-8	vascular endothelial growth factor A	Rattus norvegicus	107-111
30918132-2	2019	Therefore, the aim of the present study was to investigate the therapeutic effects of curcumin against chronic renal failure (CRF) in a rat model induced by 5/6 nephrectomy through inhibition of mTOR/HIF-1alpha/VEGF signaling.	Curcumin	86-94	vascular endothelial growth factor A	Rattus norvegicus	211-215
31143210-0	2019	Curcumin suppresses epithelial-to-mesenchymal transition of peritoneal mesothelial cells (HMrSV5) through regulation of transforming growth factor-activated kinase 1 (TAK1).	Curcumin	0-8	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	120-165
31143210-0	2019	Curcumin suppresses epithelial-to-mesenchymal transition of peritoneal mesothelial cells (HMrSV5) through regulation of transforming growth factor-activated kinase 1 (TAK1).	Curcumin	0-8	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	167-171
31143210-17	2019	Conclusions: Our results demonstrate that curcumin showed an obvious protective effect on PDS-induced EMT of HMrSV5 cells and suggest implication of the TAK1, p38 and JNK pathway in mediating the effects of curcumin in EMT of MCs.	Curcumin	207-215	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	153-157
19374255-6	2009	Results showed that MMP-9 activity increased gradually in endometriotic tissues with severity and curcumin treatment reversed the MMP-9 activity near to control value.	Curcumin	98-106	matrix metallopeptidase 9	Mus musculus	130-135
19374255-9	2009	In addition, the attenuated activity of MMP-9 was associated with decreased expression of tumor necrosis factor-alpha (TNF-alpha) during healing, suggesting the anti-inflammatory property of curcumin.	Curcumin	191-199	matrix metallopeptidase 9	Mus musculus	40-45
31096703-3	2019	Moreover, curcumin regulated the expression of the glial cell markers in ethanol-treated mice brains, as analyzed by the relative expression TLR4 (Toll like Receptor 4), RAGE (Receptor for Advanced Glycations End products), GFAP (Glial fibrillary acidic protein), and Iba-1 (Ionized calcium binding adaptor molecule 1), through Western blot and confocal microscopic analysis.	Curcumin	10-18	glial fibrillary acidic protein	Mus musculus	224-228
31096703-3	2019	Moreover, curcumin regulated the expression of the glial cell markers in ethanol-treated mice brains, as analyzed by the relative expression TLR4 (Toll like Receptor 4), RAGE (Receptor for Advanced Glycations End products), GFAP (Glial fibrillary acidic protein), and Iba-1 (Ionized calcium binding adaptor molecule 1), through Western blot and confocal microscopic analysis.	Curcumin	10-18	glial fibrillary acidic protein	Mus musculus	230-261
19374255-11	2009	We reported here for the first time the anti-endometriotic property of curcumin via MMP-9 dependent pathway that may lead to new therapeutic intervention.	Curcumin	71-79	matrix metallopeptidase 9	Mus musculus	84-89
30663793-0	2019	Curcumin reduces inflammation in knee osteoarthritis rats through blocking TLR4 /MyD88/NF-kappaB signal pathway.	Curcumin	0-8	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	81-86
18495463-8	2009	Importantly, BDMC and DMC at 10 microM reduced MT1-MMP and TIMP-2 protein expression, but curcumin slightly reduced only MT1-MMP but not TIMP-2.	Curcumin	90-98	matrix metallopeptidase 14	Homo sapiens	121-128
30663793-12	2019	However, curcumin treatment can significantly decrease the expression of MyD88, p-IkappaBalpha, NF-kappaB, TNF-alpha, IL-1beta, and IL6 in OA + curcumin group.	Curcumin	9-17	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	73-78
30663793-12	2019	However, curcumin treatment can significantly decrease the expression of MyD88, p-IkappaBalpha, NF-kappaB, TNF-alpha, IL-1beta, and IL6 in OA + curcumin group.	Curcumin	9-17	NFKB inhibitor alpha	Rattus norvegicus	82-94
18841445-0	2009	Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice.	Curcumin	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	34-39
30988793-5	2019	Morphological changes, the expression levels of the bone-associated gene markers bone morphogenetic protein 2, runt-related transcription factor and osterix during differentiation, an in vitro mineralization assay, and changes in osteocalcin expression revealed that curcumin supplementation promoted the osteogenic differentiation of BMSCs.	Curcumin	267-275	bone gamma-carboxyglutamate protein 2	Mus musculus	230-241
18841445-0	2009	Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice.	Curcumin	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	40-45
18841445-1	2009	PURPOSE: To evaluate the in vivo efficacy of curcumin as an inhibitor of the multidrug-resistance-linked ATP Binding Cassette (ABC) drug transporter, ABCG2.	Curcumin	45-53	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	150-155
19093868-2	2009	The downstream targets regulated by AMP-activated protein kinase (AMPK) for inhibiting adipocyte differentiation or cancer cell proliferation of curcumin were investigated.	Curcumin	145-153	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	36-64
19093868-2	2009	The downstream targets regulated by AMP-activated protein kinase (AMPK) for inhibiting adipocyte differentiation or cancer cell proliferation of curcumin were investigated.	Curcumin	145-153	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	66-70
30690117-0	2019	Biophysical analysis of interaction between curcumin and alpha-2-macroglobulin.	Curcumin	44-52	alpha-2-macroglobulin	Homo sapiens	57-78
19093868-3	2009	The activation of AMPK by curcumin was crucial for the inhibition of differentiation or growth in both adipocytes and cancer cells.	Curcumin	26-34	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	18-22
30690117-4	2019	In the present study, we have explored the interaction of curcumin with alpha2M using various technique such as antiproteinase activity assay, spectroscopy.	Curcumin	58-66	alpha-2-macroglobulin	Homo sapiens	72-79
19093868-4	2009	Stimulation of AMPK by curcumin resulted in the down-regulation of PPAR (peroxisome proliferator-activated receptor)-gamma in 3T3-L1 adipocytes and the decrease in COX-2 in MCF-7 cells.	Curcumin	23-31	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	15-19
30690117-5	2019	Changes in the secondary structure of alpha2M following interaction with curcumin was investigated by CD and FT-IR spectroscopy.	Curcumin	73-81	alpha-2-macroglobulin	Homo sapiens	38-45
30690117-6	2019	Thermodynamics of curcumin-alpha2M binding were also analyzed by isothermal titration calorimetry to identify the number of binding sites, changes in enthalpy, entropy and Gibbs free energy changes for this interaction.	Curcumin	18-26	alpha-2-macroglobulin	Homo sapiens	27-34
19093868-7	2009	Regulation of AMPK and its downstream targets such as PPAR-gamma, Mapkinases, and COX-2 by curcumin appears to be important in controlling adipocytes and cancerous cells.	Curcumin	91-99	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	14-18
30690117-8	2019	Our results suggest that the binding of curcumin with alpha2M induces a conformational change in the native form of protein that compromises its anti-proteinase activity.	Curcumin	40-48	alpha-2-macroglobulin	Homo sapiens	54-61
19889203-10	2009	The modulatory effects of curcumin and resveratrol on IL-1beta-induced expression of cartilage specific matrix and proinflammatory enzymes were mediated in part by the cartilage-specific transcription factor Sox-9.	Curcumin	26-34	SRY-box transcription factor 9	Homo sapiens	208-213
31005718-12	2019	Moreover, curcumin down-regulated the mRNA expression of Vimentin, Fibronectin, and beta-catenin, and up-regulated E-cadherin mRNA expression levels.	Curcumin	10-18	vimentin	Homo sapiens	57-65
31005718-12	2019	Moreover, curcumin down-regulated the mRNA expression of Vimentin, Fibronectin, and beta-catenin, and up-regulated E-cadherin mRNA expression levels.	Curcumin	10-18	catenin beta 1	Homo sapiens	84-96
31005718-13	2019	Western blot analysis demonstrated that curcumin decreased the protein expression of stem cell genes including Oct4, Nanog and Sox2.	Curcumin	40-48	POU class 5 homeobox 1	Homo sapiens	111-115
31027362-8	2019	The phytochemicals like sulforaphane and curcumin that can concurrently target SOX9, AR and Wnt/beta-catenin signaling pathways in PCa may thus be beneficial in the chemoprevention of PCa.	Curcumin	41-49	catenin beta 1	Homo sapiens	96-108
19018768-0	2008	Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT.	Curcumin	0-8	aryl hydrocarbon receptor	Homo sapiens	126-129
31086728-0	2019	A combination of curcumin, vorinostat and silibinin reverses Abeta-induced nerve cell toxicity via activation of AKT-MDM2-p53 pathway.	Curcumin	17-25	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	122-125
30987250-10	2019	Results: Our findings showed that curcumin significantly decreased insulin and IGF-1 receptors in addition to MYC expression.	Curcumin	34-42	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	110-113
31073274-9	2019	We found that OVA-induced airway inflammation and mucus hypersecretion in mice, OVA and IL-4-induced upregulation of MCP-1 and MUC5AC, suppression of PPARgamma, and activation and translocation of NF-kappaB p65 were notably improved by curcumin both in vivo and in vitro.	Curcumin	236-244	interleukin 4	Mus musculus	88-92
31073274-11	2019	Taken together, our results indicate that curcumin attenuated OVA-induced airway inflammation and mucus hypersecretion in mice and suppressed OVA- and IL-4-induced upregulation of MCP-1 and MUC5AC both in vivo and in vitro, most likely through a PPARgamma-dependent NF-kappaB signaling pathway.	Curcumin	42-50	interleukin 4	Mus musculus	151-155
19018768-6	2008	Notably, the nuclear levels of arylhydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) were decreased by curcumin, but those in the cytoplasm were not.	Curcumin	116-124	aryl hydrocarbon receptor	Homo sapiens	31-55
19018768-6	2008	Notably, the nuclear levels of arylhydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) were decreased by curcumin, but those in the cytoplasm were not.	Curcumin	116-124	aryl hydrocarbon receptor	Homo sapiens	57-60
30260594-0	2019	Nicotinate-curcumin ameliorates cognitive impairment in diabetic rats by rescuing autophagic flux in CA1 hippocampus.	Curcumin	11-19	carbonic anhydrase 1	Rattus norvegicus	101-104
19018768-7	2008	It was also found that oxidative stress mediated the curcumin-induced degradations of AhR and ARNT.	Curcumin	53-61	aryl hydrocarbon receptor	Homo sapiens	86-89
19018768-9	2008	In conclusion, curcumin attenuates AhR/ARNT-mediated CYP induction by dioxin and presumably this mode-of-action may be responsible for the curcumin prevention of malignant transformation.	Curcumin	15-23	aryl hydrocarbon receptor	Homo sapiens	35-38
19018768-9	2008	In conclusion, curcumin attenuates AhR/ARNT-mediated CYP induction by dioxin and presumably this mode-of-action may be responsible for the curcumin prevention of malignant transformation.	Curcumin	139-147	aryl hydrocarbon receptor	Homo sapiens	35-38
18695642-8	2008	In vivo, curcumin also prevented MLD-STZ, as revealed by sustained normoglycaemia, normal glucose clearance and maintained pancreatic GLUT2 levels.	Curcumin	9-17	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	134-139
30738291-0	2019	Curcumin attenuates murine lupus via inhibiting NLRP3 inflammasome.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	48-53
30738291-11	2019	In addition, curcumin reduced NLRP3 inflammasome activation in lupus-prone mice.	Curcumin	13-21	NLR family, pyrin domain containing 3	Mus musculus	30-35
30738291-12	2019	In vitro, curcumin significantly inhibited anti-dsDNA+ serum induced expression of NLRP3 inflammasome in podocytes.	Curcumin	10-18	NLR family, pyrin domain containing 3	Mus musculus	83-88
30816425-10	2019	Curcumin was demonstrated to improve nerve damage symptoms and infarct volume, reduce brain water content, relieve neuronal apoptosis and also increase the expression of p-MEK, p-ERK, p-CREB, Bcl-2 and reduce Bax levels in vivo and in vitro.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	209-212
30816425-11	2019	In conclusion curcumin can mitigate focal cerebral ischemia-reperfusion injuries and this effect may be carried out through the MEK/ERK/CREB pathway.	Curcumin	14-22	cAMP responsive element binding protein 1	Rattus norvegicus	136-140
18368483-6	2008	Results also revealed that curcumin treatment decreased LPS-induced activation of two transcription factors--nuclear factors kappaB (NF-kappaB) and activator protein-1 (AP-1).	Curcumin	27-35	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	148-167
30816479-9	2019	These results suggest that curcumin and resveratrol exert protective effects on DSS-induced UC, partially through suppressing the intestinal inflammatory cascade reaction, reducing autophagy and regulating SIRT1/mTOR signaling.	Curcumin	27-35	sirtuin 1	Mus musculus	206-211
30816479-9	2019	These results suggest that curcumin and resveratrol exert protective effects on DSS-induced UC, partially through suppressing the intestinal inflammatory cascade reaction, reducing autophagy and regulating SIRT1/mTOR signaling.	Curcumin	27-35	mechanistic target of rapamycin kinase	Mus musculus	212-216
18368483-6	2008	Results also revealed that curcumin treatment decreased LPS-induced activation of two transcription factors--nuclear factors kappaB (NF-kappaB) and activator protein-1 (AP-1).	Curcumin	27-35	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	169-173
30889901-0	2019	Curcumin Analogue C1 Promotes Hex and Gal Recruitment to the Plasma Membrane via mTORC1-Independent TFEB Activation.	Curcumin	0-8	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	18-20
18794131-5	2008	The HLJ1 promoter and enhancer in a luciferase reporter assay revealed that curcumin transcriptionally up-regulates HLJ1 expression through an activator protein (AP-1) site within the HLJ1 enhancer.	Curcumin	76-84	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	162-166
30889901-1	2019	The monocarbonyl analogue of curcumin (1E,4E)-1,5-Bis(2-methoxyphenyl)penta-1,4-dien-3-one (C1) has been used as a specific activator of the master gene transcription factor EB (TFEB) to correlate the activation of this nuclear factor with the increased activity of lysosomal glycohydrolases and their recruitment to the cell surface.	Curcumin	29-37	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	92-94
30889901-4	2019	Treatment of Jurkat cells with the curcumin analogue C1 also resulted in an increase of both lysosomal glycohydrolase activity and their targeting to the cell surface.	Curcumin	35-43	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	53-55
30668349-0	2019	Augmented cytotoxic effects of paclitaxel by curcumin induced overexpression of folate receptor-alpha for enhanced targeted drug delivery in HeLa cells.	Curcumin	45-53	folate receptor alpha	Homo sapiens	80-101
30668349-9	2019	The quantitative RT-PCR demonstrates the expression of FR- alpha mRNA upon curcumin treatment.	Curcumin	75-83	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	55-64
30668349-10	2019	Furthermore, immunochemistry and western blotting analysis proved that curcumin enhances expression the FR- alpha in HeLa cells.	Curcumin	71-79	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	104-113
30668349-11	2019	CONCLUSION: Our study proved that the molecular mechanism of curcumin enhances the upregulation of FR - alpha mRNA and protein expression in HeLa cells.	Curcumin	61-69	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	99-109
30515807-10	2019	skn-1mRNA was significantly elevated in nematodes treated with curcumin and C4 indicating SKN-1/Nrf activation as a possible mode of action.	Curcumin	63-71	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	0-5
30515807-10	2019	skn-1mRNA was significantly elevated in nematodes treated with curcumin and C4 indicating SKN-1/Nrf activation as a possible mode of action.	Curcumin	63-71	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	90-95
30881359-7	2019	Previously we have reported that both carnosol and curcumin can regulate the maturation and function of human DC through upregulation of the immunomodulatory enzyme, Heme Oxygenase-1 (HO-1).	Curcumin	51-59	heme oxygenase 1	Homo sapiens	166-182
18794131-6	2008	JunD, one of the AP-1 components, was significantly up-regulated by curcumin (1-20 mumol/L) in a concentration- and time-dependent manner.	Curcumin	68-76	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
30881359-7	2019	Previously we have reported that both carnosol and curcumin can regulate the maturation and function of human DC through upregulation of the immunomodulatory enzyme, Heme Oxygenase-1 (HO-1).	Curcumin	51-59	heme oxygenase 1	Homo sapiens	184-188
18794131-6	2008	JunD, one of the AP-1 components, was significantly up-regulated by curcumin (1-20 mumol/L) in a concentration- and time-dependent manner.	Curcumin	68-76	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-21
30881359-10	2019	This study therefore describes a novel relationship between metabolic signaling via AMPK and HO-1 induction by carnosol and curcumin in human DC, and characterizes the effects of these polyphenols on DC immunometabolism for the first time.	Curcumin	124-132	heme oxygenase 1	Homo sapiens	93-97
18794131-7	2008	Knockdown of JunD expression could partially reduce the curcumin-induced HLJ1 activation and diminish the anti-invasive effect of curcumin, indicating that JunD would seem to be involved in curcumin-induced HLJ1 expression.	Curcumin	56-64	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-17
30825198-0	2019	Activation of PERK in ET-1- and thrombin-induced pulmonary fibroblast differentiation: Inhibitory effects of curcumin.	Curcumin	109-117	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	14-18
18794131-7	2008	Knockdown of JunD expression could partially reduce the curcumin-induced HLJ1 activation and diminish the anti-invasive effect of curcumin, indicating that JunD would seem to be involved in curcumin-induced HLJ1 expression.	Curcumin	56-64	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	156-160
30825198-1	2019	In the present study, we investigated the role of PKR-like endoplasmic reticular kinase (PERK), an endoplasmic reticulum (ER) stress kinase, in endothelin 1 (ET-1)- and thrombin-induced pulmonary fibrosis (PF), and the preventive effects of curcumin (CUR).	Curcumin	241-249	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	89-93
30392062-0	2019	Curcumin ameliorates PRMT5-MEP50 arginine methyltransferase expression by decreasing the Sp1 and NF-YA transcription factors in the A549 and MCF-7 cells.	Curcumin	0-8	WD repeat domain 77	Homo sapiens	27-32
30392062-4	2019	We exposed the lung and breast cancer cell lines (A549 and MCF-7) to curcumin (2 and 20 muM) and observed a highly significant inhibitory effect on the expression of both PRMT5 and MEP50.	Curcumin	69-77	WD repeat domain 77	Homo sapiens	181-186
18556656-3	2008	Time- and concentration-dependent inhibition of immunodetectable [(33)P]orthophosphate in UGTs and protein kinase Cepsilon (PKCepsilon), following treatment of LS180 cells with curcumin or the PKC inhibitor calphostin-C, suggested UGT phosphorylation is supported by active PKC(s).	Curcumin	177-185	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	90-93
30392062-9	2019	Altogether, we report a new molecular target of curcumin and further elucidation of this proposed mechanism through which curcumin affects the PRMT5-MEP50 methyltransferase expression might be explored for its therapeutic application.	Curcumin	48-56	WD repeat domain 77	Homo sapiens	149-154
30392062-9	2019	Altogether, we report a new molecular target of curcumin and further elucidation of this proposed mechanism through which curcumin affects the PRMT5-MEP50 methyltransferase expression might be explored for its therapeutic application.	Curcumin	122-130	WD repeat domain 77	Homo sapiens	149-154
30968152-16	2019	Furthermore, curcumin abolished NF-kappaB signal transduction and protected the cells from CPT-11-induced apoptosis by upregulating the expression of molecular chaperones, such as GRP78, P4HB and PRDX4, and suppressing the levels of the apoptosis-related proteins, CHOP and cleaved caspase-3.	Curcumin	13-21	DNA-damage inducible transcript 3	Rattus norvegicus	265-269
31168341-0	2019	Protective effects of curcumin on diabetic nephropathy via attenuation of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression and alleviation of oxidative stress in rats with type 1 diabetes.	Curcumin	22-30	hepatitis A virus cellular receptor 1	Rattus norvegicus	74-98
31168341-0	2019	Protective effects of curcumin on diabetic nephropathy via attenuation of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression and alleviation of oxidative stress in rats with type 1 diabetes.	Curcumin	22-30	hepatitis A virus cellular receptor 1	Rattus norvegicus	100-105
31168341-2	2019	The present study was conducted to examine the protective effect of curcumin on the expression of KIM-1, NGAL genes and oxidative damage in the kidney of T1D rats.	Curcumin	68-76	hepatitis A virus cellular receptor 1	Rattus norvegicus	98-103
31168341-10	2019	Curcumin administration had a significant role in modulation of serum lipid profile, and it was shown to decrease the kidney and urinary expression levels of KIM-1 and NGAL genes and improve oxidative toxic stress in the kidney tissues.	Curcumin	0-8	hepatitis A virus cellular receptor 1	Rattus norvegicus	158-163
30863716-4	2019	This study also introduces the binding site characterization of H1R, with its known antagonists and Curcumin (our proposed alternative H1R antagonist); useful for future drug target site.	Curcumin	100-108	histamine receptor H1	Homo sapiens	64-67
30863716-4	2019	This study also introduces the binding site characterization of H1R, with its known antagonists and Curcumin (our proposed alternative H1R antagonist); useful for future drug target site.	Curcumin	100-108	histamine receptor H1	Homo sapiens	135-138
30863716-5	2019	The interactive binding site residues of H1R are found to be; Lys-191, Tyr-108, Asp-107, Tyr-100, Lys-179, Lys-191, Thr-194, Trp-428, Phe-432, Tyr-458, Hie-450, with most of these shown to be inhibited by naturally-occurring compound curcumin.	Curcumin	234-242	histamine receptor H1	Homo sapiens	41-44
30863716-7	2019	The known antagonists of H1R has been used for hypothesizing curcumin as naturally occurring lead compound for the target using accurate molecular docking simulation study.	Curcumin	61-69	histamine receptor H1	Homo sapiens	25-28
30736288-10	2019	Taken together, the data identify curcumin and EGCG as novel ferroptosis inhibitors, which might exert their protective effects by acting as iron chelators and preventing GSH depletion, GPX4 inactivation, and lipid peroxidation in MIN6 cells.	Curcumin	34-42	glutathione peroxidase 4	Mus musculus	186-190
30816479-8	2019	Furthermore, curcumin or resveratrol significantly downregulated the expression of autophagy-related 12, Beclin-1 and microtubule-associated protein light chain 3 II, and upregulated the expression of phosphorylated mTOR and SIRT1 in the colon tissue, compared with those in the DSS-treated group.	Curcumin	13-21	autophagy related 12	Mus musculus	83-103
30816479-8	2019	Furthermore, curcumin or resveratrol significantly downregulated the expression of autophagy-related 12, Beclin-1 and microtubule-associated protein light chain 3 II, and upregulated the expression of phosphorylated mTOR and SIRT1 in the colon tissue, compared with those in the DSS-treated group.	Curcumin	13-21	beclin 1, autophagy related	Mus musculus	105-165
30816479-8	2019	Furthermore, curcumin or resveratrol significantly downregulated the expression of autophagy-related 12, Beclin-1 and microtubule-associated protein light chain 3 II, and upregulated the expression of phosphorylated mTOR and SIRT1 in the colon tissue, compared with those in the DSS-treated group.	Curcumin	13-21	mechanistic target of rapamycin kinase	Mus musculus	216-220
18556656-5	2008	Inhibition of UGT activity by PKCepsilon-specific antagonist peptide or by PKCepsilon-targeted destruction with PKCepsilon-specific small interference RNA and activation of curcumin-down-regulated UGTs with typical PKC agonists verified a central PKC role in glucuronidation.	Curcumin	173-181	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	14-17
29945277-10	2019	In addition, curcumin downregulated Ctr1 and OCT2 drug transporters as compared to cisplatin group.	Curcumin	13-21	solute carrier family 31 member 1	Rattus norvegicus	36-40
18501560-8	2008	Moreover, pretreatment with p300 inhibitor (curcumin) also blocked IL-8 expression.	Curcumin	44-52	E1A binding protein p300	Homo sapiens	28-32
30816479-8	2019	Furthermore, curcumin or resveratrol significantly downregulated the expression of autophagy-related 12, Beclin-1 and microtubule-associated protein light chain 3 II, and upregulated the expression of phosphorylated mTOR and SIRT1 in the colon tissue, compared with those in the DSS-treated group.	Curcumin	13-21	sirtuin 1	Mus musculus	225-230
30816509-4	2019	The uptake rates for curcumin in OATP1B1-, OATP1B3- and OATP2B1-transfected CHO cells were 2- to 3-fold higher than wild-type cells.	Curcumin	21-29	solute carrier organic anion transporter family member 1B1	Homo sapiens	33-40
30816509-7	2019	The increased mRNA levels of OATP1B1 in wild-type human breast cancer ZR-75-1 cells compared with OATP1B1 knockdown cells was associated with a higher initial uptake of curcumin and tetrahydrocurcumin leading to decreased IC50 values.	Curcumin	169-177	solute carrier organic anion transporter family member 1B1	Homo sapiens	29-36
18593936-5	2008	Moreover, using RNA interference with small inhibitory RNAs for Sp1, Sp3, and Sp4, we observed that curcumin-dependent inhibition of nuclear factor kappaB (NF-kappaB)-dependent genes, such as bcl-2, survivin, and cyclin D1, was also due, in part, to loss of Sp proteins.	Curcumin	100-108	cyclin D1	Homo sapiens	213-222
30816509-7	2019	The increased mRNA levels of OATP1B1 in wild-type human breast cancer ZR-75-1 cells compared with OATP1B1 knockdown cells was associated with a higher initial uptake of curcumin and tetrahydrocurcumin leading to decreased IC50 values.	Curcumin	169-177	solute carrier organic anion transporter family member 1B1	Homo sapiens	98-105
30988630-0	2019	A novel curcumin derivative CL-6 exerts antitumor effect in human gastric cancer cells by inducing apoptosis through Hippo-YAP signaling pathway.	Curcumin	8-16	insulin induced gene 1	Homo sapiens	28-32
18397880-6	2008	The increase in eNOS mRNA caused by shear was completely blocked by pharmacological inhibition of p300/HAT activity with curcumin or by p300 small interfering RNA.	Curcumin	121-129	E1A binding protein p300	Homo sapiens	98-102
30988630-2	2019	As a new generation of cancer therapeutic drug, CL-6, a curcumin derivative, shows better bioavailability than curcumin, which has shown anticancer effects in gastric cancer (GC).	Curcumin	56-64	insulin induced gene 1	Homo sapiens	48-52
30988630-2	2019	As a new generation of cancer therapeutic drug, CL-6, a curcumin derivative, shows better bioavailability than curcumin, which has shown anticancer effects in gastric cancer (GC).	Curcumin	111-119	insulin induced gene 1	Homo sapiens	48-52
30988630-10	2019	These results indicate the therapeutic potential of the novel curcumin derivative CL-6 in GC.	Curcumin	62-70	insulin induced gene 1	Homo sapiens	82-86
18221818-8	2008	After 120 min exposure to 25 microM curcumin, hepatic glucose-6-phosphatase (G6Pase) activity and phosphoenolpyruvate carboxykinase (PEPCK) activity both were inhibited by 30%, but fructose-1,6-bisphosphatase (FBPase) was not reduced.	Curcumin	36-44	glucose-6-phosphatase, catalytic	Mus musculus	54-75
30794412-3	2019	Consistent with this postulate, aglycone, but not glucuronidated, curcumin inhibited RANKL-stimulated osteoclastogenesis, a key curcumin target in bone.	Curcumin	66-74	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	85-90
30794412-6	2019	These findings suggest that curcumin, despite low systemic bioavailability, may be enzymatically activated (deconjugated) within GUSB-enriched bone to exert protective effects, a metabolic process that could also contribute to bone-protective effects of other highly glucuronidated dietary polyphenols.	Curcumin	28-36	glucuronidase, beta	Mus musculus	129-133
18221818-8	2008	After 120 min exposure to 25 microM curcumin, hepatic glucose-6-phosphatase (G6Pase) activity and phosphoenolpyruvate carboxykinase (PEPCK) activity both were inhibited by 30%, but fructose-1,6-bisphosphatase (FBPase) was not reduced.	Curcumin	36-44	glucose-6-phosphatase, catalytic	Mus musculus	77-83
18221818-10	2008	Thus, the anti-diabetic effects of curcumin are partly due to a reduction in hepatic glucose production caused by activation of AMP kinase and inhibition of G6Pase activity and PEPCK activity.	Curcumin	35-43	glucose-6-phosphatase, catalytic	Mus musculus	157-163
30894572-6	2019	We found that both siRNA-mediated knockdown of USP10 and treatment with the USP10 inhibitor, spautin-1, effectively attenuated curcumin-induced paraptosis.	Curcumin	127-135	ubiquitin specific peptidase 10	Homo sapiens	47-52
18182168-6	2008	LPS-induced VCAM-1 expression was also blocked by pretreatment with curcumin (a p300 inhibitor) or transfection with p300 siRNA.	Curcumin	68-76	E1A binding protein p300	Homo sapiens	80-84
30894572-6	2019	We found that both siRNA-mediated knockdown of USP10 and treatment with the USP10 inhibitor, spautin-1, effectively attenuated curcumin-induced paraptosis.	Curcumin	127-135	ubiquitin specific peptidase 10	Homo sapiens	76-81
30872773-8	2019	JAK2 activity was inhibited using either curcumin, a natural compound with strong JAK2 inhibitor activity, or Tofacitinib, a clinically used selective JAK small molecule inhibitor.	Curcumin	41-49	Janus kinase 2	Mus musculus	0-4
31025030-11	2019	Moreover, GLUT3 and GLUT4 levels were significantly increased in Curcumin-treated AD rats.	Curcumin	65-73	solute carrier family 2 member 4	Rattus norvegicus	20-25
18394334-0	2008	[Effect and mechanism of curcumin on learning and memory dysfunction induced by gp120 in rats].	Curcumin	25-33	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	80-85
30841550-5	2019	Notably, anti-inflammatory and antioxidant properties of curcumin might reduce the expression of tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) and restore the imbalance between reactive oxygen species (ROS) production and antioxidant activity.	Curcumin	57-65	interleukin 1 alpha	Homo sapiens	141-160
18394334-1	2008	AIM: To explore the effect and mechanisms of curcumin on learning and memory dysfunction induced by HIV-1 enveloped protein gp120.	Curcumin	45-53	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	124-129
30775806-11	2019	Data showed the serum decrease of LDH, CK, and cTnI in infarct rats after curcumin intake compared to the rats given (ISO) ( P &lt; 0.05).	Curcumin	74-82	troponin I3, cardiac type	Rattus norvegicus	47-51
18394334-14	2008	The curcumin can improve the learning and memory dysfunction induced by gp120, the mechanism may be related to against the downregulation the expression of NMDA2BR.	Curcumin	4-12	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	72-77
18204486-0	2008	Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy.	Curcumin	113-121	mitogen activated protein kinase 14	Rattus norvegicus	95-98
30668362-0	2019	Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex.	Curcumin	32-40	mechanistic target of rapamycin kinase	Mus musculus	52-56
30668362-2	2019	Recent studies suggest that curcumin inhibit mTOR activity in vitro, which prompts us to investigate curcumin function as a new class of mTOR inhibitor suitable for tuberous sclerosis complex (TSC) treatment.	Curcumin	28-36	mechanistic target of rapamycin kinase	Mus musculus	45-49
30668362-2	2019	Recent studies suggest that curcumin inhibit mTOR activity in vitro, which prompts us to investigate curcumin function as a new class of mTOR inhibitor suitable for tuberous sclerosis complex (TSC) treatment.	Curcumin	101-109	mechanistic target of rapamycin kinase	Mus musculus	137-141
30668362-2	2019	Recent studies suggest that curcumin inhibit mTOR activity in vitro, which prompts us to investigate curcumin function as a new class of mTOR inhibitor suitable for tuberous sclerosis complex (TSC) treatment.	Curcumin	101-109	TSC complex subunit 2	Mus musculus	193-196
30668362-3	2019	PURPOSE: We aim to investigate the efficacy of curcumin in the treatment of TSC related manifestations in animal model.	Curcumin	47-55	TSC complex subunit 2	Mus musculus	76-79
30668362-4	2019	STUDY DESIGN: Solid lipid curcumin particle (SLCP), a novel curcumin formulation, was used to treat TSC related manifestations in Tsc2 knockout mice.	Curcumin	26-34	TSC complex subunit 2	Mus musculus	100-103
18204486-10	2008	However, curcumin treatment prevented this increase in HSP-27 and p38 expression.	Curcumin	9-17	heat shock protein family B (small) member 1	Rattus norvegicus	55-61
30668362-4	2019	STUDY DESIGN: Solid lipid curcumin particle (SLCP), a novel curcumin formulation, was used to treat TSC related manifestations in Tsc2 knockout mice.	Curcumin	26-34	TSC complex subunit 2	Mus musculus	130-134
18204486-10	2008	However, curcumin treatment prevented this increase in HSP-27 and p38 expression.	Curcumin	9-17	mitogen activated protein kinase 14	Rattus norvegicus	66-69
30312017-0	2019	Curcumin Ameliorates Memory Deficits by Enhancing Lactate Content and MCT2 Expression in APP/PS1 Transgenic Mouse Model of Alzheimer"s Disease.	Curcumin	0-8	presenilin 1	Mus musculus	93-96
18204486-12	2008	CONCLUSIONS AND IMPLICATIONS: Our results suggested that protection against development of diabetic nephropathy by curcumin treatment involved changes in post-translational modifications of histone H3, expression of HSP-27 and MAP kinase p38 in diabetic kidney.	Curcumin	115-123	heat shock protein family B (small) member 1	Rattus norvegicus	216-222
30312017-7	2019	Results showed that spatial learning and memory deficits were improved in curcumin-treated APP/PS1 mouse group compared with those in APP/PS1 mice group.	Curcumin	74-82	presenilin 1	Mus musculus	95-98
30312017-8	2019	Brain lactate content and MCT2 protein level were increased in curcumin-treated APP/PS1 mice than in APP/PS1 mice.	Curcumin	63-71	presenilin 1	Mus musculus	84-87
18204486-12	2008	CONCLUSIONS AND IMPLICATIONS: Our results suggested that protection against development of diabetic nephropathy by curcumin treatment involved changes in post-translational modifications of histone H3, expression of HSP-27 and MAP kinase p38 in diabetic kidney.	Curcumin	115-123	mitogen activated protein kinase 14	Rattus norvegicus	238-241
30312017-9	2019	In summary, our findings indicate that curcumin could ameliorate memory impairments in APP/PS1 mouse model of AD.	Curcumin	39-47	presenilin 1	Mus musculus	91-94
18316600-2	2008	Curcumin inhibits cancer cell proliferation in part by suppressing cyclin D1 and inducing expression of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1).	Curcumin	0-8	cyclin D1	Homo sapiens	67-76
30800209-4	2019	Curcumin could significantly suppress the above HSC-induced effects in HCC and could abrogate ROS and HIF-1alpha expression in HCC.	Curcumin	0-8	fucosyltransferase 1 (H blood group)	Homo sapiens	48-51
18001810-6	2008	Curcumin was also found to reduce quartz-induced cytotoxicity and cyclooxygenase 2 (COX-2) mRNA expression in RLE-6TN rat lung epithelial cells (RLE).	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	66-82
18001810-6	2008	Curcumin was also found to reduce quartz-induced cytotoxicity and cyclooxygenase 2 (COX-2) mRNA expression in RLE-6TN rat lung epithelial cells (RLE).	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	84-89
18001810-7	2008	Curcumin also inhibited the release of macrophage inflammatory protein-2 (MIP-2) from RLE cells as observed upon treatment with interleukin-1 beta (IL-1beta) and tumour necrosis factor-alpha (TNFalpha).	Curcumin	0-8	C-X-C motif chemokine ligand 2	Rattus norvegicus	39-72
30367912-5	2019	On the other hand, co-administration of curcumin, a polyphenol extract from the rhizome of Curcuma longa L, along with PTU ameliorates PTU- induced oxidative stress and epigenetic parameters except for the expression of MBD4.	Curcumin	40-48	methyl-CpG binding domain 4 DNA glycosylase	Rattus norvegicus	220-224
31287789-10	2019	However, curcumin was more efficient in MDA- MB-231 cells than MCF-7 cells owing to its greater inhibitory efficacy in the LPS- enhanced TLR4 signaling pathway.	Curcumin	9-17	toll like receptor 4	Homo sapiens	137-141
18001810-7	2008	Curcumin also inhibited the release of macrophage inflammatory protein-2 (MIP-2) from RLE cells as observed upon treatment with interleukin-1 beta (IL-1beta) and tumour necrosis factor-alpha (TNFalpha).	Curcumin	0-8	C-X-C motif chemokine ligand 2	Rattus norvegicus	74-79
31287789-11	2019	Furthermore, IFN-alpha/beta levels induced by TLR4 and IRF3 were decreased in these cells following curcumin treatment.	Curcumin	100-108	toll like receptor 4	Homo sapiens	46-50
17965732-10	2008	On the other hand, interruption of ERK signalling by inhibitors or dominant negative ERK, like curcumin, reduced NF-kappaB activity and in ctgf expression.	Curcumin	95-103	cellular communication network factor 2	Homo sapiens	139-143
31287789-12	2019	CONCLUSIONS: Consequently, these results demonstrated that the activation of LPS stimulated TLR4/TRIF/IRF3 signaling pathway was mediated by curcumin in breast cancer cells, in vitro.	Curcumin	141-149	toll like receptor 4	Homo sapiens	92-96
31287789-13	2019	However, more studies are necessary to examine the curcumin"s anti-inflammatory activities on TLR4/MyD88/NF-kappaB as well as other signaling pathways downstream of TLRs in breast cancer.	Curcumin	51-59	toll like receptor 4	Homo sapiens	94-98
17965732-12	2008	CONCLUSIONS AND IMPLICATIONS: These results demonstrate that the interruption of NF-kappaB and ERK signalling by curcumin results in the suppression of ctgf expression in activated HSC in vitro.	Curcumin	113-121	cellular communication network factor 2	Homo sapiens	152-156
30655747-0	2019	Apoptosis of mouse myeloma cells induced by curcumin via the Notch3-p53 signaling axis.	Curcumin	44-52	transformation related protein 53, pseudogene	Mus musculus	68-71
30655747-4	2019	The present study was designed to investigate the antitumor effect of curcumin by the Notch3-p53 axis in mouse myeloma P3X63Ag8 cells.	Curcumin	70-78	transformation related protein 53, pseudogene	Mus musculus	93-96
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	tumor necrosis factor receptor superfamily, member 10b	Mus musculus	76-84
30655747-14	2019	These data indicated that curcumin exhibited antitumor effects in mouse myeloma cells with induction of apoptosis by affecting the Notch3-p53 signaling axis.	Curcumin	26-34	transformation related protein 53, pseudogene	Mus musculus	138-141
30655872-9	2019	The expression levels of DNA methyltransferase (DNMT)3a and DNMT3b were increased in curcumin-treated cells.	Curcumin	85-93	DNA methyltransferase 3 alpha	Homo sapiens	25-55
30655872-9	2019	The expression levels of DNA methyltransferase (DNMT)3a and DNMT3b were increased in curcumin-treated cells.	Curcumin	85-93	DNA methyltransferase 3 beta	Homo sapiens	60-66
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	tumor necrosis factor receptor superfamily, member 10b	Mus musculus	85-88
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	matrix metallopeptidase 9	Mus musculus	224-229
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	BCL2-like 1	Mus musculus	241-247
18383847-6	2008	To investigate the effect of curcumin on NFkappaB activation, the protein levels of the NFkappaB subunit p65 of curcumin-treated cells were compared to untreated cells using Western blots.	Curcumin	112-120	RELA proto-oncogene, NF-kB subunit	Homo sapiens	105-108
18389075-8	2008	When muscles from septic rats were treated with curcumin in vitro, proteasome-, calpain-, and cathepsin L-dependent protein breakdown rates were reduced, and nuclear NF-kappaB/p65 expression and activity as well as levels of phosphorylated (activated) p38 were decreased.	Curcumin	48-56	mitogen activated protein kinase 14	Rattus norvegicus	252-255
30567342-6	2018	Our predictions were in agreement with the scientific literature and confirmed that curcumin binds to folate receptor beta, DNA (cytosine-5)-methyltransferase 3A, metalloproteinase-2, mitogen-activated protein kinase 9, epidermal growth factor receptor and apoptosis-inducing factor 1.	Curcumin	84-92	folate receptor beta	Homo sapiens	102-122
30321530-0	2018	Curcumin ameliorates scopolamine-induced mice memory retrieval deficit and restores hippocampal p-Akt and p-GSK-3beta.	Curcumin	0-8	glycogen synthase kinase 3 beta	Mus musculus	108-117
30518397-8	2018	Molecular docking was performed to evaluate the interaction of curcumin with JAK2.	Curcumin	63-71	Janus kinase 2	Mus musculus	77-81
17996675-4	2007	The administration of curcumin to inflammation-induced rabbits also caused downregulation of MMP-9.	Curcumin	22-30	matrix metalloproteinase-9	Oryctolagus cuniculus	93-98
30268739-9	2018	Further curcumin significantly enhanced the levels of antioxidant enzymes in BALF along with stabilized expression of hypoxia inducible factor 1(HIF-1alpha) followed by reduced expression of vascular endothelial growth factor (VEGF) in lungs of rats.	Curcumin	8-16	vascular endothelial growth factor A	Rattus norvegicus	191-225
30268739-9	2018	Further curcumin significantly enhanced the levels of antioxidant enzymes in BALF along with stabilized expression of hypoxia inducible factor 1(HIF-1alpha) followed by reduced expression of vascular endothelial growth factor (VEGF) in lungs of rats.	Curcumin	8-16	vascular endothelial growth factor A	Rattus norvegicus	227-231
17973899-0	2007	The role of haem oxygenase-1 in the decrease of endothelial intercellular adhesion molecule-1 expression by curcumin.	Curcumin	108-116	intercellular adhesion molecule 1	Mus musculus	60-93
30605865-1	2019	The present study was carried out to evaluate: the antiepileptic effect of dietary curcumin, and the effect of epileptic state and curcumin on the molecular expression of voltage-activated Na+ channel subtypes Nav1.1 and Nav1.6 in the iron-induced experimental epilepsy in the rat.	Curcumin	131-139	neuron navigator 1	Rattus norvegicus	210-214
17973899-3	2007	We investigated the role of HO-1 in the action of curcumin, a naturally occurring yellow pigment isolated from plant Curcuma longa L., on ICAM-1 expression in tumour necrosis factor-alpha-stimulated EA.hy926 cells and lungs of lipopolysaccharide-treated mice.	Curcumin	50-58	intercellular adhesion molecule 1	Mus musculus	138-144
30605865-1	2019	The present study was carried out to evaluate: the antiepileptic effect of dietary curcumin, and the effect of epileptic state and curcumin on the molecular expression of voltage-activated Na+ channel subtypes Nav1.1 and Nav1.6 in the iron-induced experimental epilepsy in the rat.	Curcumin	131-139	neuron navigator 1	Rattus norvegicus	221-225
17973899-4	2007	Both, in vitro and in vivo curcumin induced HO-1 and curcumin-elicited induction of HO-1 was associated with inhibition ICAM-1 expression.	Curcumin	53-61	intercellular adhesion molecule 1	Mus musculus	120-126
30605865-7	2019	Epileptic rats fed with curcumin showed a marked decrease in epileptiform activity, and reduced mRNA and protein levels of Nav1.1.	Curcumin	24-32	neuron navigator 1	Rattus norvegicus	123-127
30605865-8	2019	It appears that the antiepileptic action of curcumin may be associated with the downregulation of Nav1.1 in the cortex.	Curcumin	44-52	neuron navigator 1	Rattus norvegicus	98-102
30538473-4	2018	Methods: Peptide transporter 1 (PepT1)-mediated micelles (Val-PMs/Phe-PMs) were designed by grafting valine (or phenylalanine) onto the surface of curcumin (Cur)-loaded-D-alpha-tocopheryl polyethylene glycol 1000 succinate micelles (TP-PMs).	Curcumin	147-155	solute carrier family 15 member 1	Rattus norvegicus	9-30
30538473-4	2018	Methods: Peptide transporter 1 (PepT1)-mediated micelles (Val-PMs/Phe-PMs) were designed by grafting valine (or phenylalanine) onto the surface of curcumin (Cur)-loaded-D-alpha-tocopheryl polyethylene glycol 1000 succinate micelles (TP-PMs).	Curcumin	147-155	solute carrier family 15 member 1	Rattus norvegicus	32-37
17973899-7	2007	We conclude that induction of HO-1, via decrease of endothelial ICAM-1, plays a pivotal role in curcumin-dependent prevention of pulmonary sequestration of neutrophils in a mouse model of endotoxaemia.	Curcumin	96-104	intercellular adhesion molecule 1	Mus musculus	64-70
30538473-4	2018	Methods: Peptide transporter 1 (PepT1)-mediated micelles (Val-PMs/Phe-PMs) were designed by grafting valine (or phenylalanine) onto the surface of curcumin (Cur)-loaded-D-alpha-tocopheryl polyethylene glycol 1000 succinate micelles (TP-PMs).	Curcumin	157-160	solute carrier family 15 member 1	Rattus norvegicus	9-30
30538473-4	2018	Methods: Peptide transporter 1 (PepT1)-mediated micelles (Val-PMs/Phe-PMs) were designed by grafting valine (or phenylalanine) onto the surface of curcumin (Cur)-loaded-D-alpha-tocopheryl polyethylene glycol 1000 succinate micelles (TP-PMs).	Curcumin	157-160	solute carrier family 15 member 1	Rattus norvegicus	32-37
30467667-6	2019	Apoptotic effect of curcumin was determined by PI and Annexin V/PI FACS flow analysis.	Curcumin	20-28	annexin A5	Homo sapiens	54-63
18156803-5	2007	Curcumin induced the expression of cyclin-dependent kinase (CDK) inhibitors p16(/INK4a), p21(/WAF1/CIP1) and p27(/KIP1), and inhibited the expression of cyclin E and cyclin D1, and hyperphosphorylation of retinoblastoma (Rb) protein.	Curcumin	0-8	cyclin D1	Homo sapiens	166-175
30800669-6	2019	It was found that, after 14 days of the induction by curcumin, NTERA2 cells showed neuronal morphology and expressed neural-specific genes, including NeuroD, TUJ1, and PAX6.	Curcumin	53-61	neuronal differentiation 1	Homo sapiens	150-156
31679307-0	2019	Curcumin Modulates Hepatocellular Carcinoma by Reducing UNC119 Expression.	Curcumin	0-8	unc-119 lipid binding chaperone	Mus musculus	56-62
30534177-4	2018	Promoter deletion analysis demonstrated that the -177 to -83 region, which includes putative binding sites for transcription factors NFY, CREB/ATF, SP1, EGR3, and MZF1, acts as the curcumin-responsive promoter of the hST3Gal V gene.	Curcumin	181-189	early growth response 3	Homo sapiens	153-157
30534177-4	2018	Promoter deletion analysis demonstrated that the -177 to -83 region, which includes putative binding sites for transcription factors NFY, CREB/ATF, SP1, EGR3, and MZF1, acts as the curcumin-responsive promoter of the hST3Gal V gene.	Curcumin	181-189	myeloid zinc finger 1	Homo sapiens	163-167
31679307-3	2019	The study described here aimed to explore the potential of curcumin in modulation of UNC119 expression in HCC by assessment with quantitative real-time PCR, western blot, and immune-histochemical analyses in HCC cell lines and tissues.	Curcumin	59-67	unc-119 lipid binding chaperone	Mus musculus	85-91
18156803-5	2007	Curcumin induced the expression of cyclin-dependent kinase (CDK) inhibitors p16(/INK4a), p21(/WAF1/CIP1) and p27(/KIP1), and inhibited the expression of cyclin E and cyclin D1, and hyperphosphorylation of retinoblastoma (Rb) protein.	Curcumin	0-8	RB transcriptional corepressor 1	Homo sapiens	221-223
30393127-0	2019	Curcumin, but not curcumin-glucuronide, inhibits Smad signaling in TGFbeta-dependent bone metastatic breast cancer cells and is enriched in bone compared to other tissues.	Curcumin	0-8	transforming growth factor alpha	Mus musculus	67-74
18156803-6	2007	Lactacystin, an inhibitor of 26 proteasome, blocks curcumin-induced down-regulation of cyclin D1 and cyclin E proteins, suggesting their regulation at level of posttranslation.	Curcumin	51-59	cyclin D1	Homo sapiens	87-96
30393127-2	2019	In prior experiments, turmeric-derived curcumin inhibited in vivo BMET progression and in vitro TGFbeta/Smad-signaling in a TGFbeta-stimulated PTHrP-dependent human xenograft BCa BMET model (MDA-SA cells).	Curcumin	39-47	transforming growth factor alpha	Mus musculus	96-103
30137697-0	2018	Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice.	Curcumin	10-18	heart and neural crest derivatives expressed 2	Mus musculus	108-111
30393127-2	2019	In prior experiments, turmeric-derived curcumin inhibited in vivo BMET progression and in vitro TGFbeta/Smad-signaling in a TGFbeta-stimulated PTHrP-dependent human xenograft BCa BMET model (MDA-SA cells).	Curcumin	39-47	transforming growth factor alpha	Mus musculus	124-131
30137697-0	2018	Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice.	Curcumin	10-18	notch 1	Mus musculus	184-190
30393127-6	2019	Similarly, curcumin, but not curcumin-glucuronide, blocked TGFbeta-stimulated secretion of PTHrP from MDA-SA and 4T1 cells.	Curcumin	11-19	transforming growth factor alpha	Mus musculus	59-66
18156803-7	2007	The suppression of cyclin D1 and cyclin E by curcumin may inhibit CDK-mediated phosphorylation of pRb protein.	Curcumin	45-53	cyclin D1	Homo sapiens	19-28
30741618-6	2018	The result displayed that Curcumin pretreatment can significantly increase the expression of p-JAK2 and p-STAT3 and reduce the expression of Cr, BUN, IL-8, TNF-alpha, IL-6, and p-p65.	Curcumin	26-34	signal transducer and activator of transcription 3	Rattus norvegicus	106-111
18156803-7	2007	The suppression of cyclin D1 and cyclin E by curcumin may inhibit CDK-mediated phosphorylation of pRb protein.	Curcumin	45-53	RB transcriptional corepressor 1	Homo sapiens	98-101
30393127-9	2019	Thus, curcumin, and not curcumin-glucuronide, appears to inhibit bone-tropic BCa cell TGFbeta-signaling and to undergo site-specific activation (deconjugation) within the bone microenvironment.	Curcumin	6-14	transforming growth factor alpha	Mus musculus	86-93
17880909-4	2007	Moreover, curcumin significantly inhibited the TCDD-induced activation of protein kinase C (PKC), which is involved in the transformation, decreased the TCDD-induced DNA-binding activity of the AhR/Arnt heterodimer, and downregulated CYP1A1 expression.	Curcumin	10-18	aryl hydrocarbon receptor	Homo sapiens	194-197
31287789-0	2019	Inhibition of TLR4/TRIF/IRF3 Signaling Pathway by Curcumin in Breast Cancer Cells.	Curcumin	50-58	toll like receptor 4	Homo sapiens	14-18
31287789-5	2019	For this purpose, we explored the inhibitory effects of curcumin on lipopolysaccharide (LPS)-induced TLR4 dependent TRIF signaling pathway in two subtypes of breast cancer cell lines (MCF-7 and MDA-MB-231) in this study.	Curcumin	56-64	toll like receptor 4	Homo sapiens	101-105
17640567-5	2007	The reducing agent also counteracted the inhibitory effects of curcumin on TNF-induced NF-kappaB-regulated antiapoptotic (Bcl-2, Bcl-xL, IAP1), proliferative (cyclin D1), and proinflammatory (COX-2, iNOS, and MMP-9) gene products.	Curcumin	63-71	cyclin D1	Homo sapiens	159-168
31287789-9	2019	RESULTS: Curcumin treatment suppressed breast cancer cells viabilities and the activation of TLR4-mediated TRIF signaling pathway by the downregulation of TLR4 and IRF3 expression levels and the inhibition of type I IFN (IFN-alpha/beta) levels induced by LPS.	Curcumin	9-17	toll like receptor 4	Homo sapiens	93-97
31287789-9	2019	RESULTS: Curcumin treatment suppressed breast cancer cells viabilities and the activation of TLR4-mediated TRIF signaling pathway by the downregulation of TLR4 and IRF3 expression levels and the inhibition of type I IFN (IFN-alpha/beta) levels induced by LPS.	Curcumin	9-17	toll like receptor 4	Homo sapiens	155-159
30373602-4	2018	The differential IFN-gamma-induced PD-L1 expression and STAT1 activation were examined in curcumin and apigenin-treated melanoma cells using immunoblotting or immunofluorescence assays.	Curcumin	90-98	CD274 molecule	Homo sapiens	35-40
17197075-4	2007	To address the molecular mechanisms involved, we performed experiments with specific inhibitors against putative targets of curcumin, including IkappaB kinase (IKK), epidermal growth factor receptor (EGFR), phosphatidylinositol-3 kinase (PI3K)/Akt, and matrix metalloproteinases (MMPs).	Curcumin	124-132	matrix metallopeptidase 2	Rattus norvegicus	280-284
30053224-8	2019	The gene expression levels of fatty acid synthase (FAS) and sterol regulatory element binding protein-1c (SREBP-1c) were significantly decreased in all curcumin groups (P &lt; 0.05), but the gene expression levels of acetyl CoA carboxylase (ACC) and ATP-citrate lyase (ACLY) were significantly decreased only in the 2,000 mg/kg curcumin group (P &lt; 0.05).	Curcumin	152-160	fatty acid synthase	Gallus gallus	30-49
30053224-8	2019	The gene expression levels of fatty acid synthase (FAS) and sterol regulatory element binding protein-1c (SREBP-1c) were significantly decreased in all curcumin groups (P &lt; 0.05), but the gene expression levels of acetyl CoA carboxylase (ACC) and ATP-citrate lyase (ACLY) were significantly decreased only in the 2,000 mg/kg curcumin group (P &lt; 0.05).	Curcumin	152-160	fatty acid synthase	Gallus gallus	51-54
30053224-10	2019	These results indicated that curcumin plays an important role in reduction abdominal fat deposition by decreasing the hepatic and plasma lipid profile and affecting the expression levels of genes related to lipogenesis and lipolysis including ACC, FAS, SREBP-1c, ACLY, PPARalpha, and CPT-I.	Curcumin	29-37	fatty acid synthase	Gallus gallus	248-251
30350003-6	2018	Furthermore, curcumin-loaded CS-BSA NPs inhibited the TLR4-MAPK/NF-kappaB signaling pathway and further downregulated M1 macrophage polarization.	Curcumin	13-21	toll like receptor 4	Homo sapiens	54-58
17197075-6	2007	Western blot analysis and gelatin zymography revealed that curcumin, but not berberine, has an inhibitory effect on the phosphorylation of Akt and enzymatic activity of MMP-2 in TR-LE cells.	Curcumin	59-67	matrix metallopeptidase 2	Rattus norvegicus	169-174
17197075-7	2007	These results suggest that curcumin exerts its inhibitory effect on lymphangiogenesis partly through Akt and MMP-2.	Curcumin	27-35	matrix metallopeptidase 2	Rattus norvegicus	109-114
30603704-4	2018	In the present work, we engineered nanoscale G4 polyamidoamine (PAMAM) dendrimers anchored to galactosamine and loaded with the potent anticancer curcumin derivative (CDF) as a platform for targeted drug delivery to HCC.	Curcumin	146-154	LIF interleukin 6 family cytokine	Homo sapiens	167-170
17637178-10	2007	Whereas most unmethylated polyphenols, such as curcumin and quercetin, have very poor bioavailability, the high metabolic stability of the methoxylated flavones studied here suggests that these CYP1B1 inhibitors may also be effective in-vivo.	Curcumin	47-55	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	194-200
30545070-8	2018	In addition, curcumin also exerts anti-amyloidogenic effects and affects the brain"s tau protein.	Curcumin	13-21	microtubule associated protein tau	Homo sapiens	85-88
30402507-0	2018	Downregulation of Interleukin- (IL-) 17 through Enhanced Indoleamine 2,3-Dioxygenase (IDO) Induction by Curcumin: A Potential Mechanism of Tolerance towards Helicobacter pylori.	Curcumin	104-112	indoleamine 2,3-dioxygenase 1	Homo sapiens	86-89
17449203-7	2007	Mutation analyses revealed that the region including antioxidant response element (ARE), which overlaps AP1 in sequence, was essential to the response to curcumin.	Curcumin	154-162	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-107
30402507-3	2018	The aim of this study was to investigate the role of curcumin in modulating the expression of IL-17 and IDO in H. pylori-infected human gastric mucosa.	Curcumin	53-61	indoleamine 2,3-dioxygenase 1	Homo sapiens	104-107
30402507-7	2018	Curcumin downregulates IL-17 production through the induction of IDO in H. pylori-infected human gastric mucosa, suggesting its role in dampening H. pylori-induced immune-mediated inflammatory changes.	Curcumin	0-8	indoleamine 2,3-dioxygenase 1	Homo sapiens	65-68
30333956-5	2018	Treatment of HNSCC cell lines with curcumin, a natural compound isolated from rhizomes of the plant Curcuma longa, or transfection of small interfering RNA of Skp2, causes down-regulation of Skp2 with concomitant accumulation of p21 and p27 in HPV+, HPV- cells.	Curcumin	35-43	interferon alpha inducible protein 27	Homo sapiens	237-240
29644554-5	2018	The anti-inflammatory effect of curcumin was associated with the repression of phosphorylation of IKKalpha-IKKbeta, and JNK.	Curcumin	32-40	conserved helix-loop-helix ubiquitous kinase	Mus musculus	98-123
30066930-6	2018	The results indicated that curcumin and paclitaxel induced apoptosis and necrosis, which was demonstrated through multiple methods, including assays of caspase-3/7 activity, Annexin V, poly(ADP-ribose) polymerase-1 activation and protein expression of caspase-3, nuclear factor (NF)-kappaB transcription factor and proliferating cell nuclear antigen.	Curcumin	27-35	annexin A5	Homo sapiens	174-183
30531680-9	2018	RESULTS We found that curcumin has cytotoxic activity in human glioma CHME cells, as shown by DAPI staining, annexin V/PI, and nuclear morphology.	Curcumin	22-30	annexin A5	Homo sapiens	109-118
30584274-9	2018	Curcumin and rapamycin treatment inhibited the increased levels of proinflammatory cytokines including IL-1beta, TNF-alpha, MMP-1, and MMP-3 in CIA rats.	Curcumin	0-8	matrix metallopeptidase 1	Rattus norvegicus	124-129
29183161-3	2018	The effects of curcumin-encapsulated HA-PLA NPs on the viability of LPS/IFN-gamma stimulated peritoneal macrophages were determined using MTT assay.	Curcumin	15-23	interferon regulatory factor 6	Homo sapiens	68-71
29183161-8	2018	The change in macrophage phenotype by curcumin-encapsulated HA-PLA NPs could suppress the inflammation in LPS/IFN-gamma stimulated macrophages as evidenced by a major reduction in pro-inflammatory cytokines.	Curcumin	38-46	interferon regulatory factor 6	Homo sapiens	106-109
17531121-19	2007	The activities of MMP-2 and MMP-9 were enhanced significantly by curcumin.	Curcumin	65-73	matrix metallopeptidase 2	Rattus norvegicus	18-23
30144665-10	2018	The findings also suggested curcumin"s potential in protecting HT22 cells against acrolein through regulating the BDNF/TrkB signaling.	Curcumin	28-36	brain derived neurotrophic factor	Mus musculus	114-118
17531121-20	2007	CONCLUSIONS: Curcumin can inhibit the proliferation and activation of HSCs, induce the apoptosis of activated HSCs and enhance the activities of MMP-2 and MMP-9.	Curcumin	13-21	matrix metallopeptidase 2	Rattus norvegicus	145-150
17332930-8	2007	Furthermore, curcumin inhibited expression of phosphatidyl-inositol-3 kinase (PI3K) p110 and p85 subunits, and phosphorylation of Ser 473 AKT/PKB.	Curcumin	13-21	endogenous retrovirus group K member 15	Homo sapiens	84-88
30064791-1	2018	Soy protein isolate (SPI) was first treated with glutaminase to yield modified SPI (E-SPI) before its complexation with curcumin.	Curcumin	120-128	TLE family member 4, transcriptional corepressor	Homo sapiens	21-24
30064791-2	2018	Comparisons were made between SPI and E-SPI concerning their characteristics and effectiveness in complexing with curcumin, along with changes in physicochemical properties, 2,2-diphenyl-1-picryhydrazyl (DPPH)-scavenging capacity and storage stability of curcumin upon complexation.	Curcumin	114-122	TLE family member 4, transcriptional corepressor	Homo sapiens	30-33
17431105-9	2007	Tumors from animals treated with liposomal curcumin showed an antiangiogenic effect, including attenuation of CD31 (an endothelial marker), vascular endothelial growth factor, and interleukin-8 expression by immunohistochemistry.	Curcumin	43-51	platelet and endothelial cell adhesion molecule 1	Homo sapiens	110-114
30143976-0	2018	Curcumin confers hepatoprotection against AFB1-induced toxicity via activating autophagy and ameliorating inflammation involving Nrf2/HO-1 signaling pathway.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	134-138
30195880-0	2018	Curcumin enhances cisplatin sensitivity of human NSCLC cell lines through influencing Cu-Sp1-CTR1 regulatory loop.	Curcumin	0-8	solute carrier family 31 member 1	Homo sapiens	93-97
30195880-4	2018	PURPOSE: This study aims to investigate whether curcumin enhances cisplatin sensitivity of human non-small cell lung cancer (NSCLC) through influencing Cu-Sp1-CTR1 regulatory loop.	Curcumin	48-56	solute carrier family 31 member 1	Homo sapiens	159-163
30195880-10	2018	Curcumin treatment enhances the binding of Sp1 to CTR1 and Sp1 promoters, thus induces CTR1 expression and chemosensitization to cisplatin treatment.	Curcumin	0-8	solute carrier family 31 member 1	Homo sapiens	50-54
30195880-10	2018	Curcumin treatment enhances the binding of Sp1 to CTR1 and Sp1 promoters, thus induces CTR1 expression and chemosensitization to cisplatin treatment.	Curcumin	0-8	solute carrier family 31 member 1	Homo sapiens	87-91
30143976-9	2018	Moreover, curcumin treatment significantly (p &lt; 0.05) elevated AFB1-induced decrease in Nrf2 and HO-1 mRNA and protein expression level.	Curcumin	10-18	heme oxygenase 1	Homo sapiens	100-104
17435663-9	2007	Inhibition of MMP-9 in curcumin-supplemented N2a cells was revealed by zymographic analysis.	Curcumin	23-31	matrix metallopeptidase 9	Mus musculus	14-19
30302613-8	2018	Both CNM and curcumin activated the nuclear factor erythroid 2 related factor 2 (Nrf2) and restored levels of downstream antioxidant enzymes superoxide dismutase and glutathione-S-transferase (GST) in the hippocampus.	Curcumin	13-21	hematopoietic prostaglandin D synthase	Mus musculus	166-191
30302613-8	2018	Both CNM and curcumin activated the nuclear factor erythroid 2 related factor 2 (Nrf2) and restored levels of downstream antioxidant enzymes superoxide dismutase and glutathione-S-transferase (GST) in the hippocampus.	Curcumin	13-21	hematopoietic prostaglandin D synthase	Mus musculus	193-196
29746885-0	2018	Curcumin inhibits hepatic stellate cell activation via suppression of succinate-associated HIF-1alpha induction.	Curcumin	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	91-101
29746885-5	2018	RESULTS: Oral administration of curcumin and metformin combated mitochondrial fatty acid oxidation and reduced hepatic succinate accumulation due to the inhibition of succinate dehydrogenase (SDH) activity and demonstrated inhibitory effect on hepatic fibrosis.	Curcumin	32-40	aminoadipate-semialdehyde synthase	Mus musculus	167-190
29746885-5	2018	RESULTS: Oral administration of curcumin and metformin combated mitochondrial fatty acid oxidation and reduced hepatic succinate accumulation due to the inhibition of succinate dehydrogenase (SDH) activity and demonstrated inhibitory effect on hepatic fibrosis.	Curcumin	32-40	aminoadipate-semialdehyde synthase	Mus musculus	192-195
29746885-6	2018	In mouse primary HSCs, curcumin prevented succinate- and CoCl2-induced hypoxia-inducible transcription factor-1alpha (HIF-1alpha) induction via suppression of ROS production and effectively reduced gene expressions of Col1alpha, Col3alpha, fibronectin and TGF-beta1 with inflammation inhibition.	Curcumin	23-31	hypoxia inducible factor 1, alpha subunit	Mus musculus	118-128
29746885-6	2018	In mouse primary HSCs, curcumin prevented succinate- and CoCl2-induced hypoxia-inducible transcription factor-1alpha (HIF-1alpha) induction via suppression of ROS production and effectively reduced gene expressions of Col1alpha, Col3alpha, fibronectin and TGF-beta1 with inflammation inhibition.	Curcumin	23-31	fibronectin 1	Mus musculus	240-251
29746885-9	2018	Curcumin reduced succinate accumulation by combating fatty acid oxidation and prevented HSCs activation by blocking succinate/HIF-1alpha signaling pathway.	Curcumin	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	126-136
30466981-9	2018	To further understand the potential mechanism, EGCG, tannic acid, and curcumin were tested to check whether they have the ability to inhibit P-gp activity.	Curcumin	70-78	phosphoglycolate phosphatase	Homo sapiens	141-145
30466981-14	2018	A Rhodamine 123 assay and Calcein-AM assay in Caco-2 and CEM/ADR 5000, respectively, were used to detect P-gp inhibition by EGCG, curcumin, and tannic acid.	Curcumin	130-138	phosphoglycolate phosphatase	Homo sapiens	105-109
30466981-20	2018	Consistent with the combination results, tannic acid and curcumin decreased the activity of P-gp both in Caco-2 and CEM/ADR 5000.	Curcumin	57-65	phosphoglycolate phosphatase	Homo sapiens	92-96
30195880-12	2018	Moreover, the enhancement mediated by curcumin on cisplatin therapeutic efficacy in cultured human NSCLC cell lines (A549, H460, H1299) was dependent on CTR1.	Curcumin	38-46	solute carrier family 31 member 1	Homo sapiens	153-157
30130550-0	2018	Upregulation of klotho and erythropoietin contributes to the neuroprotection induced by curcumin-loaded nanoparticles in experimental model of chronic epilepsy.	Curcumin	88-96	erythropoietin	Mus musculus	27-41
30130550-2	2018	The present study is an attempt to examine the potential role of klotho and EPO in therapeutic effect of curcumin-loaded nanoparticles (NPs) in pentylenetetrazol (PTZ)-induced kindling model.	Curcumin	105-113	erythropoietin	Mus musculus	76-79
30130550-10	2018	Curcumin-loaded NPs effectively upregulated the levels of EPO and klotho in PTZ receiving animals.	Curcumin	0-8	erythropoietin	Mus musculus	58-61
30130550-12	2018	Overall, the results of this study suggest that downregulation of TNF-alpha and consequent upregulation of klotho and EPO might contribute to the neuroprotective effect of curcumin-loaded NPs in experimental model of epilepsy.	Curcumin	172-180	erythropoietin	Mus musculus	118-121
29157028-0	2018	Enhanced selective cellular uptake and cytotoxicity of epidermal growth factor-conjugated liposomes containing curcumin on EGFR-overexpressed pancreatic cancer cells.	Curcumin	111-119	epidermal growth factor	Homo sapiens	55-78
29157028-3	2018	In this study, we examined the effect of epidermal growth factor (EGF)-conjugated liposomes containing curcumin (EGF-LP-Cur) on three different EGFR-expressed human pancreatic cancer cell lines, BxPC-3, Panc-1 and Mia Paca-2.	Curcumin	103-111	epidermal growth factor	Homo sapiens	66-69
29157028-7	2018	In summary, our results have showed that targeting EGFR with EGF-conjugated curcumin liposomes enhanced the antitumor activity of curcumin against human pancreatic cancer cells.	Curcumin	76-84	epidermal growth factor	Homo sapiens	51-54
29157028-7	2018	In summary, our results have showed that targeting EGFR with EGF-conjugated curcumin liposomes enhanced the antitumor activity of curcumin against human pancreatic cancer cells.	Curcumin	130-138	epidermal growth factor	Homo sapiens	51-54
29849119-6	2018	Furthermore, co-treatment with PP242 and curcumin-induced the downregulation of the Rictor (an mTORC2 complex protein) and Akt protein levels, and ectopic overexpression of Rictor or Akt inhibited PP242 plus curcumin induced cell death.	Curcumin	208-216	RPTOR independent companion of MTOR complex 2	Homo sapiens	173-179
30466981-22	2018	CONCLUSION: Our results show that EGCG, curcumin, and tannic acid, when combined with doxorubicin, can exert synergism, mediated by a reduced activity of P-gp.	Curcumin	40-48	phosphoglycolate phosphatase	Homo sapiens	154-158
30155758-9	2018	Curcumin has similar effects with 3-MA, in which curcumin inhibited NF-kappaB by preventing the translocation of NF-kappaB p65.	Curcumin	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	123-126
30155758-9	2018	Curcumin has similar effects with 3-MA, in which curcumin inhibited NF-kappaB by preventing the translocation of NF-kappaB p65.	Curcumin	49-57	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	123-126
30333889-7	2018	Cetuximab and curcumin combination induced apoptosis and dramatically increased caspase-3 and caspase-9 activities compared with singular treatment.	Curcumin	14-22	caspase 9	Homo sapiens	94-103
29849119-7	2018	Downregulation of Rictor increased cytosolic Ca2+ release from endoplasmic reticulum, which led to lysosomal damage in PP242 plus curcumin-treated cells.	Curcumin	130-138	RPTOR independent companion of MTOR complex 2	Homo sapiens	18-24
29849119-11	2018	Altogether, our results reveal that combined PP242 and curcumin treatment could induce autophagy-mediated cell death by reducing the expression of Rictor and Akt in renal carcinoma cells.	Curcumin	55-63	RPTOR independent companion of MTOR complex 2	Homo sapiens	147-153
17273730-0	2007	Photosensitizer effect of curcumin on UVB-irradiated HaCaT cells through activation of caspase pathways.	Curcumin	26-34	caspase 8	Homo sapiens	87-94
29723631-5	2018	Furthermore, changes in expression of the ER Stress Response (ERSR) genes IRE1 and ATF6, and the microRNAs (miRNAs) miR-27a, miR-222, miR-449 was observed after exposure to curcumin.	Curcumin	173-181	activating transcription factor 6	Homo sapiens	83-87
29723631-5	2018	Furthermore, changes in expression of the ER Stress Response (ERSR) genes IRE1 and ATF6, and the microRNAs (miRNAs) miR-27a, miR-222, miR-449 was observed after exposure to curcumin.	Curcumin	173-181	microRNA 222	Homo sapiens	125-132
29887570-0	2018	Curcumin downregulates 8-br-cAMP-induced steroidogenesis in mouse Leydig cells by suppressing the expression of Cyp11a1 and StAR independently of the PKA-CREB pathway.	Curcumin	0-8	steroidogenic acute regulatory protein	Mus musculus	124-128
30185517-0	2018	Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice.	Curcumin	31-39	peroxiredoxin 1	Mus musculus	10-25
30185517-0	2018	Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice.	Curcumin	31-39	NLR family, pyrin domain containing 3	Mus musculus	66-71
30185517-2	2018	In this study, we screened a series of small compounds with anti-inflammatory activities and identified a novel NLRP3 inflammasome inhibitor, AI-44, a curcumin analogue that selectively inhibited signal 2 but not signal 1 of NLRP3 inflammasome activation.	Curcumin	151-159	NLR family, pyrin domain containing 3	Mus musculus	112-117
29529355-0	2018	Low-dose curcumin stimulates proliferation of rat embryonic neural stem cells through glucocorticoid receptor and STAT3.	Curcumin	9-17	signal transducer and activator of transcription 3	Rattus norvegicus	114-119
17273730-6	2007	Furthermore, combination of UVB irradiation with curcumin synergistically induces apoptotic cell death in HaCaT cells through activation of caspase-8, and -3 as well as caspase-9 activation followed by release of cytochrome c.	Curcumin	49-57	caspase 8	Homo sapiens	140-157
29529355-6	2018	CONCLUSION: This study shows that low-dose curcumin stimulates the proliferation of NSCs, which is probably by inhibiting the mRNA and protein expressions of GR and directly or indirectly regulating the STAT3 via the synergistic effect of GR and STAT3 pathways and its related signal pathways.	Curcumin	43-51	signal transducer and activator of transcription 3	Rattus norvegicus	203-208
29529355-6	2018	CONCLUSION: This study shows that low-dose curcumin stimulates the proliferation of NSCs, which is probably by inhibiting the mRNA and protein expressions of GR and directly or indirectly regulating the STAT3 via the synergistic effect of GR and STAT3 pathways and its related signal pathways.	Curcumin	43-51	signal transducer and activator of transcription 3	Rattus norvegicus	246-251
17254346-10	2007	Eosinophilia in curcumin-treated mice was markedly reduced, co-stimulatory molecule expression (CD80, CD86, and OX40L) on antigen-presenting cells was decreased, and expression of MMP-9, OAT, and TSLP genes was also attenuated.	Curcumin	16-24	tumor necrosis factor (ligand) superfamily, member 4	Mus musculus	112-117
30250013-4	2018	Curcumin also inhibits Abeta and tau accumulation in animal models and enhances mitochondria and synaptic function.	Curcumin	0-8	microtubule associated protein tau	Homo sapiens	33-36
30063064-0	2018	Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14-3-3gamma.	Curcumin	0-8	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Mus musculus	141-152
17254346-10	2007	Eosinophilia in curcumin-treated mice was markedly reduced, co-stimulatory molecule expression (CD80, CD86, and OX40L) on antigen-presenting cells was decreased, and expression of MMP-9, OAT, and TSLP genes was also attenuated.	Curcumin	16-24	matrix metallopeptidase 9	Mus musculus	180-185
30116377-5	2018	In-depth study of its mechanism of action revealed that curcumin induced cell cycle arrest at the G2/M phase and decreased the expression of the CDC25 and CDC2 proteins, while increasing the expression of P21.	Curcumin	56-64	cell division cycle 25C	Homo sapiens	145-150
17254346-10	2007	Eosinophilia in curcumin-treated mice was markedly reduced, co-stimulatory molecule expression (CD80, CD86, and OX40L) on antigen-presenting cells was decreased, and expression of MMP-9, OAT, and TSLP genes was also attenuated.	Curcumin	16-24	thymic stromal lymphopoietin	Mus musculus	196-200
30116377-5	2018	In-depth study of its mechanism of action revealed that curcumin induced cell cycle arrest at the G2/M phase and decreased the expression of the CDC25 and CDC2 proteins, while increasing the expression of P21.	Curcumin	56-64	cyclin dependent kinase 1	Homo sapiens	145-149
30116377-5	2018	In-depth study of its mechanism of action revealed that curcumin induced cell cycle arrest at the G2/M phase and decreased the expression of the CDC25 and CDC2 proteins, while increasing the expression of P21.	Curcumin	56-64	H3 histone pseudogene 16	Homo sapiens	205-208
30217876-0	2018	Retraction: Gemcitabine Sensitivity Can Be Induced in Pancreatic Cancer Cells through Modulation of miR-200 and miR-21 Expression by Curcumin or Its Analogue CDF.	Curcumin	133-141	microRNA 21	Homo sapiens	112-118
17710245-7	2007	Following curcumin treatment, immunoprecipitation studies showed that the IL-8 receptor was associated with larger amounts of active Rab11 than that in control cells.	Curcumin	10-18	RAB11A, member RAS oncogene family	Homo sapiens	133-138
30056019-6	2018	The cytotoxic and apoptotic effects of curcumin were assessed by sulforhodamine B (SRB) colorimetric assay, flow cytometric cell cycle analysis, and annexin V/propidium iodide (PI) double-labeling assays.	Curcumin	39-47	annexin A5	Homo sapiens	149-158
30056019-8	2018	It was found that the silencing of HSP27 (HSP27-KD) resulted in increased treatment resistance to curcumin in CRC cells.	Curcumin	98-106	heat shock protein family B (small) member 1	Homo sapiens	35-40
30116377-7	2018	In conclusion, curcumin inhibited the proliferation of breast cancer cells and induced G2/M phase cell cycle arrest and apoptosis, which may be associated with the decrease of CDC25 and CDC2 and increase of P21 protein levels, as well as inhibition of the phosphorylation of Akt/mTOR and induction of the mitochondrial apoptotic pathway.	Curcumin	15-23	cell division cycle 25C	Homo sapiens	176-181
30116377-7	2018	In conclusion, curcumin inhibited the proliferation of breast cancer cells and induced G2/M phase cell cycle arrest and apoptosis, which may be associated with the decrease of CDC25 and CDC2 and increase of P21 protein levels, as well as inhibition of the phosphorylation of Akt/mTOR and induction of the mitochondrial apoptotic pathway.	Curcumin	15-23	cyclin dependent kinase 1	Homo sapiens	176-180
30056019-8	2018	It was found that the silencing of HSP27 (HSP27-KD) resulted in increased treatment resistance to curcumin in CRC cells.	Curcumin	98-106	heat shock protein family B (small) member 1	Homo sapiens	42-50
17710245-8	2007	These data suggest that curcumin induces the stacking of the Rab11 vesicle complex with CXCR1 and CXCR2 in the endocytic pathway.	Curcumin	24-32	RAB11A, member RAS oncogene family	Homo sapiens	61-66
30056019-9	2018	In addition, cell cycle analysis showed that the curcumin treatment caused cell cycle arrest at the G2/M phase in the control group, and apoptosis was reduced in the HSP27-KD group.	Curcumin	49-57	heat shock protein family B (small) member 1	Homo sapiens	166-174
30056019-10	2018	Curcumin treatment also resulted in a decrease in anti-apoptotic proteins, p-Akt, Akt, Bcl-2 and p-Bad, and increase in pro-apoptotic proteins Bad and c-PARP levels in the control cells but not in the HSP27-KD cells.	Curcumin	0-8	heat shock protein family B (small) member 1	Homo sapiens	201-206
29998888-0	2018	Curcumin Inhibits Lipopolysaccharide-Induced Mucin 5AC Hypersecretion and Airway Inflammation via Nuclear Factor Erythroid 2-Related Factor 2.	Curcumin	0-8	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	45-54
17710245-8	2007	These data suggest that curcumin induces the stacking of the Rab11 vesicle complex with CXCR1 and CXCR2 in the endocytic pathway.	Curcumin	24-32	C-X-C motif chemokine receptor 2	Homo sapiens	98-103
30020318-0	2018	Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy.	Curcumin	0-8	endothelin 1	Mus musculus	100-112
30056019-12	2018	Therefore, as silencing of HSP27 increases curcumin resistance by reducing apoptosis and reactive oxidative stress production, HSP27 is a potential selective target for curcumin treatment in CRC.	Curcumin	43-51	heat shock protein family B (small) member 1	Homo sapiens	27-32
30056019-12	2018	Therefore, as silencing of HSP27 increases curcumin resistance by reducing apoptosis and reactive oxidative stress production, HSP27 is a potential selective target for curcumin treatment in CRC.	Curcumin	169-177	heat shock protein family B (small) member 1	Homo sapiens	127-132
30218018-6	2018	We validated genes belonging to these pathways, such as HSPA5, SEC61B, G6PD, HMOX1 and PDE3B to be cooperatively modulated by the OPCs-curcumin combination.	Curcumin	135-143	SEC61 translocon subunit beta	Homo sapiens	63-69
17710245-9	2007	The mechanism for antiinflammatory response by curcumin may involve unique regulation of the Rab11 trafficking molecule in recycling of IL-8 receptors.	Curcumin	47-55	RAB11A, member RAS oncogene family	Homo sapiens	93-98
30218018-6	2018	We validated genes belonging to these pathways, such as HSPA5, SEC61B, G6PD, HMOX1 and PDE3B to be cooperatively modulated by the OPCs-curcumin combination.	Curcumin	135-143	heme oxygenase 1	Homo sapiens	77-82
17190766-0	2007	Effect of azoxymethane and curcumin on transcriptional levels of cyclooxygenase-1 and -2 during initiation of colon carcinogenesis.	Curcumin	27-35	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	65-88
30189596-6	2018	Taken altogether, in vitro and in vivo experiments suggest that selected natural compounds (curcumin, antroquinonol, HCD, docosanol, tetracosanol, rutin, and actinodaphnine) via molecular docking were confirmed as potential candidates of alpha-glucosidase and alpha-amylase inhibitors for treating diabetes.	Curcumin	92-100	sucrase isomaltase (alpha-glucosidase)	Mus musculus	238-255
29860219-5	2018	In the meantime, lipid synthesis has been controlled by curcumin, evidenced by the expression of CD36, SREBP-1c and FAS.	Curcumin	56-64	sterol regulatory element binding transcription factor 1	Mus musculus	103-111
29727780-6	2018	The linear calibration range for the method was 2.50-500 ng mL-1 for curcumin, COG, and COS.	Curcumin	69-77	L1 cell adhesion molecule	Mus musculus	60-64
17190766-11	2007	RESULTS: In middle-aged rats, dietary curcumin did not reduce the number of ACF and surprisingly increased colonic levels of COX-2 mRNA.	Curcumin	38-46	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	125-130
29802156-14	2018	Mechanistically, in vivo studies suggested curcumin promoted autophagy through regulating Akt/mTOR pathway.	Curcumin	43-51	mechanistic target of rapamycin kinase	Mus musculus	94-98
29802156-15	2018	In conclusion, our results demonstrate that curcumin-induced autophagy via Akt/mTOR signaling pathway contributes to the anti-OA effect of curcumin.	Curcumin	44-52	mechanistic target of rapamycin kinase	Mus musculus	79-83
29860219-7	2018	In addition, LXRalpha antagonist GGPP pretreatment weakened the curcumin effects on CYP3A, CYP7A and SREBP-1c.	Curcumin	64-72	sterol regulatory element binding transcription factor 1	Mus musculus	101-109
17190766-12	2007	Colonic COX-2 and PGE2 levels were also significantly increased in young rats fed curcumin after AOM injections.	Curcumin	82-90	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	8-13
29802156-15	2018	In conclusion, our results demonstrate that curcumin-induced autophagy via Akt/mTOR signaling pathway contributes to the anti-OA effect of curcumin.	Curcumin	139-147	mechanistic target of rapamycin kinase	Mus musculus	79-83
17190766-14	2007	CONCLUSIONS: Our study suggests that during initiation, AOM inhibits colonic COX-1 expression without affecting COX-2 and dietary curcumin may increase COX-2 expression to compensate AOM-induced reduction of COX-1 expression.	Curcumin	130-138	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	152-157
17052672-6	2006	RR1 induced TNF-alpha synthesis in macrophages in a dose-dependent manner which can be completely inhibited by the NF-kappaB inhibitor caffeic acid phenethyl ester (CAPE) or curcumin.	Curcumin	174-182	ribonucleotide reductase catalytic subunit M1	Homo sapiens	0-3
29738983-0	2018	Facile synthesis of pH-responsive polymersomes based on lipidized PEG for intracellular co-delivery of curcumin and methotrexate.	Curcumin	103-111	progestagen associated endometrial protein	Homo sapiens	66-69
29620257-0	2018	Curcumin suppresses MUC5AC production via interfering with the EGFR signaling pathway.	Curcumin	0-8	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	20-26
29620257-2	2018	Curcumin has been reported to prevent mucin 5AC (MUC5AC) production in human airway epithelial cells; however, the molecular targets of curcumin involved in regulating MUC5AC expression have remained elusive.	Curcumin	0-8	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	38-47
30150430-7	2018	RESULTS: Both FLJ and curcumin significantly reduced the proliferation and invasion of HSC-3 and SCC-25 cells.	Curcumin	22-30	serpin family B member 3	Homo sapiens	97-100
29849119-5	2018	Combined PP242 and curcumin treatment induced Bax activation and decreased expression of Mcl-1 and Bcl-2.	Curcumin	19-27	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	89-94
29849119-6	2018	Furthermore, co-treatment with PP242 and curcumin-induced the downregulation of the Rictor (an mTORC2 complex protein) and Akt protein levels, and ectopic overexpression of Rictor or Akt inhibited PP242 plus curcumin induced cell death.	Curcumin	41-49	RPTOR independent companion of MTOR complex 2	Homo sapiens	84-90
29849119-6	2018	Furthermore, co-treatment with PP242 and curcumin-induced the downregulation of the Rictor (an mTORC2 complex protein) and Akt protein levels, and ectopic overexpression of Rictor or Akt inhibited PP242 plus curcumin induced cell death.	Curcumin	41-49	RPTOR independent companion of MTOR complex 2	Homo sapiens	173-179
30115081-10	2018	RESULTS: Curcumin attenuated the production of IL-1beta and TNF-alpha in rat gingival fibroblasts stimulated by LPS, and inhibited the LPS-induced decrease in OPG/sRANKL ratio and NF-kappaB activation.	Curcumin	9-17	TNF receptor superfamily member 11B	Rattus norvegicus	159-162
30115081-12	2018	CONCLUSIONS: curcumin modulates inflammatory activity in rat periodontitis by inhibiting NF-kappaB activation and decreasing the OPG/sRANKL ratio induced by LPS.	Curcumin	13-21	TNF receptor superfamily member 11B	Rattus norvegicus	129-132
29620257-2	2018	Curcumin has been reported to prevent mucin 5AC (MUC5AC) production in human airway epithelial cells; however, the molecular targets of curcumin involved in regulating MUC5AC expression have remained elusive.	Curcumin	0-8	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	49-55
16959222-5	2006	Interferon (IFN)-beta and -gamma treatment induced IFN-stimulated responsive element (ISRE) transcriptional activity, which was efficiently inhibited by curcumin pre-treatment.	Curcumin	153-161	interferon beta 1	Homo sapiens	0-21
29802754-0	2018	Fatty liver mediated by peroxisome proliferator-activated receptor-alpha DNA methylation can be reversed by a methylation inhibitor and curcumin.	Curcumin	136-144	peroxisome proliferator activated receptor alpha	Rattus norvegicus	24-72
29802754-1	2018	OBJECTIVE: Our studies in vitro and in vivo aimed to investigate the influence of DNA methylation of peroxisome proliferator activated receptor-alpha (PPAR-alpha) gene in non-alcoholic fatty liver disease (NAFLD) pathogenesis and to observe whether the DNA methylation inhibitor 5-Aza-2"-deoxycytidine (5-Aza-CdR) and the herbal medicine curcumin might reverse the effect both in vivo and in vitro.	Curcumin	338-346	peroxisome proliferator activated receptor alpha	Rattus norvegicus	151-161
29802754-8	2018	5-Aza-CdR and curcumin treatment significantly reversed the DNA methylation levels, increased PPAR-alpha mRNA and protein expression, and improved lipid accumulation in the two steatotic models (P &lt; 0.05).	Curcumin	14-22	peroxisome proliferator activated receptor alpha	Rattus norvegicus	94-104
29802754-9	2018	CONCLUSIONS: DNA methylation at the PPAR-alpha gene is involved in the pathogenesis of NAFLD and is possibly reversible by 5-Aza-CdR and curcumin.	Curcumin	137-145	peroxisome proliferator activated receptor alpha	Rattus norvegicus	36-46
29723552-0	2018	PI3K/Akt/GSK3beta induced CREB activation ameliorates arsenic mediated alterations in NMDA receptors and associated signaling in rat hippocampus: Neuroprotective role of curcumin.	Curcumin	170-178	cAMP responsive element binding protein 1	Rattus norvegicus	26-30
29751146-10	2018	CONCLUSIONS: Curcumin treatment resulted in inhibition of PD-L1 and p-STAT3Y705 expression both in vitro and in vivo.	Curcumin	13-21	CD274 molecule	Homo sapiens	58-63
30289012-0	2018	Genipin crosslinked curcumin loaded chitosan/montmorillonite K-10 (MMT) nanoparticles for controlled drug delivery applications.	Curcumin	20-28	keratin 10	Homo sapiens	61-65
16959222-8	2006	Finally, curcumin treatment inhibited Jak2 mRNA expression as well as cyclin D1 and v-src gene expression in K562 chronic leukaemia cells.	Curcumin	9-17	Janus kinase 2	Homo sapiens	38-42
29901164-0	2018	Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling.	Curcumin	0-8	toll like receptor 4	Homo sapiens	69-73
16959222-8	2006	Finally, curcumin treatment inhibited Jak2 mRNA expression as well as cyclin D1 and v-src gene expression in K562 chronic leukaemia cells.	Curcumin	9-17	cyclin D1	Homo sapiens	70-79
29901164-1	2018	Curcumin has been revealed to inhibit liver cancer, however, no studies have reported that the mechanism of curcumin"s action on liver cancer is related to damage-associated molecular pattern (DAMP) molecules heat shock protein 70 (HSP70) and the toll-like receptor 4 (TLR4) signaling.	Curcumin	108-116	toll like receptor 4	Homo sapiens	247-267
29901164-1	2018	Curcumin has been revealed to inhibit liver cancer, however, no studies have reported that the mechanism of curcumin"s action on liver cancer is related to damage-associated molecular pattern (DAMP) molecules heat shock protein 70 (HSP70) and the toll-like receptor 4 (TLR4) signaling.	Curcumin	108-116	toll like receptor 4	Homo sapiens	269-273
16934760-9	2006	The results from screening were confirmed using BV-2 microglial cells where curcumin and analogs were shown to inhibit LPS-induced COX-2 expression; analogs identified as more potent than curcumin in the screening assay were also more potent than curcumin in preventing COX-2 expression.	Curcumin	76-84	cytochrome c oxidase II, mitochondrial	Mus musculus	131-136
29901164-2	2018	This study aimed to investigate whether the activation of TLR4 signaling by HSP70 could be inhibited by curcumin, thus investigating the possible mechanism of curcumin in the inhibition of liver cancer.	Curcumin	104-112	toll like receptor 4	Homo sapiens	58-62
29901164-2	2018	This study aimed to investigate whether the activation of TLR4 signaling by HSP70 could be inhibited by curcumin, thus investigating the possible mechanism of curcumin in the inhibition of liver cancer.	Curcumin	159-167	toll like receptor 4	Homo sapiens	58-62
29901164-5	2018	A certain concentration of curcumin was co-cultured with HepG2 and HepG2TT cells to observe the changes of HSP70 and TLR4.	Curcumin	27-35	toll like receptor 4	Homo sapiens	117-121
29901164-7	2018	Curcumin inhibited proliferation, invasion, and metastasis of HepG2 cells, caused cells to remain in the DNA S phase, promoted apoptosis, and significantly reduced intracellular HSP70, eHSP70 and TLR4 levels of HepG2TT cells.	Curcumin	0-8	toll like receptor 4	Homo sapiens	196-200
29901164-9	2018	In summary, our results demonstrated that the antitumor effect of curcumin was related to the inhibition HSP70-TLR4 signaling.	Curcumin	66-74	toll like receptor 4	Homo sapiens	111-115
29642292-6	2018	We confirmed that the cytotoxic effect of NK-92 on MDA-MB-231 was significantly enhanced in the presence of curcumin, which was highly associated with the activation of Stat4 and Stat5 proteins in NK-92.	Curcumin	108-116	signal transducer and activator of transcription 5A	Homo sapiens	179-184
29642292-7	2018	Finally, this improved anticancer effect of curcumin was correlated with decreased expression of pErk and PI3K in MDA-MB-231.	Curcumin	44-52	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	97-101
28926094-10	2018	Additionally, curcumin activated the P53 signaling pathway by up-regulating P53 and P21, which also inhibited PI3K pathway through down-regulating PI3K, p-Akt, and p-mTOR.	Curcumin	14-22	H3 histone pseudogene 16	Homo sapiens	84-87
30004453-5	2018	Deletion analysis demonstrated that the -1146 to -646 region, which includes the putative c-Ets-1, CREB, AP-1, and NF-kappaB binding sites, functions as the curcumin-responsive promoter of hST8Sia I in A549 cells.	Curcumin	157-165	ETS proto-oncogene 1, transcription factor	Homo sapiens	90-97
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P&lt;0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P&gt;0.05).	Curcumin	48-56	notch 1	Mus musculus	141-147
16934760-9	2006	The results from screening were confirmed using BV-2 microglial cells where curcumin and analogs were shown to inhibit LPS-induced COX-2 expression; analogs identified as more potent than curcumin in the screening assay were also more potent than curcumin in preventing COX-2 expression.	Curcumin	76-84	cytochrome c oxidase II, mitochondrial	Mus musculus	270-275
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P&lt;0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P&gt;0.05).	Curcumin	48-56	notch 1	Mus musculus	269-276
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P&lt;0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P&gt;0.05).	Curcumin	91-99	notch 1	Mus musculus	141-147
29620257-2	2018	Curcumin has been reported to prevent mucin 5AC (MUC5AC) production in human airway epithelial cells; however, the molecular targets of curcumin involved in regulating MUC5AC expression have remained elusive.	Curcumin	136-144	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	168-174
29620257-3	2018	The present study aimed to elucidate the molecular mechanisms by which curcumin regulates MUC5AC production, utilizing the NCI-H292 human airway epithelial cell line featuring MUC5AC hypersecretion.	Curcumin	71-79	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	90-96
29620257-3	2018	The present study aimed to elucidate the molecular mechanisms by which curcumin regulates MUC5AC production, utilizing the NCI-H292 human airway epithelial cell line featuring MUC5AC hypersecretion.	Curcumin	71-79	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	176-182
29620257-4	2018	Curcumin was able to counteract the endothelial growth factor (EGF)-stimulated mRNA and protein expression of MUC5AC.	Curcumin	0-8	epidermal growth factor	Homo sapiens	36-61
29620257-4	2018	Curcumin was able to counteract the endothelial growth factor (EGF)-stimulated mRNA and protein expression of MUC5AC.	Curcumin	0-8	epidermal growth factor	Homo sapiens	63-66
29620257-4	2018	Curcumin was able to counteract the endothelial growth factor (EGF)-stimulated mRNA and protein expression of MUC5AC.	Curcumin	0-8	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	110-116
29620257-5	2018	In addition, curcumin treatment prevented EGF-induced phosphorylation of EGF receptor (EGFR) as well as the downstream AKT and signal transducer and activator of transcription 3 (STAT3), while inhibition of PI3K and STAT3 signaling significantly attenuated the expression of MUC5AC that was induced by EGF.	Curcumin	13-21	epidermal growth factor	Homo sapiens	42-45
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P&lt;0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P&gt;0.05).	Curcumin	91-99	notch 1	Mus musculus	269-276
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P&lt;0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P&gt;0.05).	Curcumin	91-99	notch 1	Mus musculus	141-147
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P&lt;0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P&gt;0.05).	Curcumin	91-99	notch 1	Mus musculus	269-276
29620257-5	2018	In addition, curcumin treatment prevented EGF-induced phosphorylation of EGF receptor (EGFR) as well as the downstream AKT and signal transducer and activator of transcription 3 (STAT3), while inhibition of PI3K and STAT3 signaling significantly attenuated the expression of MUC5AC that was induced by EGF.	Curcumin	13-21	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	275-281
29620257-5	2018	In addition, curcumin treatment prevented EGF-induced phosphorylation of EGF receptor (EGFR) as well as the downstream AKT and signal transducer and activator of transcription 3 (STAT3), while inhibition of PI3K and STAT3 signaling significantly attenuated the expression of MUC5AC that was induced by EGF.	Curcumin	13-21	epidermal growth factor	Homo sapiens	73-76
17041101-7	2006	Analysis of the effects of the analogues on the expression of cancer-related genes usually affected by curcumin indicated that some induced the down-regulation of beta-catenin, Ki-ras, cyclin D1, c-Myc, and ErbB-2 at as low as one eighth the concentration at which curcumin normally has an effect.	Curcumin	265-273	cyclin D1	Homo sapiens	185-194
29620257-6	2018	Furthermore, EGF-induced increases in the levels of phosphorylated STAT3 in the nuclear fraction were inhibited by curcumin and PI3K inhibitors.	Curcumin	115-123	epidermal growth factor	Homo sapiens	13-16
29620257-7	2018	In addition, treatment with curcumin significantly decreased MUC5AC and EGFR expression in a time-dependent manner under basal conditions.	Curcumin	28-36	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	61-67
29620257-8	2018	These results demonstrated that curcumin inhibited MUC5AC protein expression in NCI-H292 cells under basal conditions as well under EGF stimulation.	Curcumin	32-40	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	51-57
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P&lt;0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P&gt;0.05).	Curcumin	91-99	notch 1	Mus musculus	141-147
29804421-4	2018	HE staining showed the most obvious necrosis of curcumin-PDT group with DAPT.Both DAPT and curcumin-PDT could reduce the expression level of Notch1 in mRNA.The inhibition rates were 42.17% and 40.54%, respectively.And the inhibitory effect of curcumin-PDT with DAPT on Notch-1 was the strongest (79.22%) (P&lt;0.01), and two of them had synergistic effect after combination with curcumin-PDT.But the expression of Notch-2 has no obvious inhibitory effect (P&gt;0.05).	Curcumin	91-99	notch 1	Mus musculus	269-276
29804421-5	2018	Both DAPT and curcumin-PDT can inhibit the protein expression of Notch1, NF-kappaB and VEGF, and two of them have synergistic effect after combined use.	Curcumin	14-22	notch 1	Mus musculus	65-71
29620257-8	2018	These results demonstrated that curcumin inhibited MUC5AC protein expression in NCI-H292 cells under basal conditions as well under EGF stimulation.	Curcumin	32-40	epidermal growth factor	Homo sapiens	132-135
16642480-8	2006	When compared with AG490, a well-characterized JAK2 inhibitor, curcumin was more rapid (30 min vs. 4 hr) and more potent (25 microM vs. 100 microM) inhibitor of STAT3 phosphorylation.	Curcumin	63-71	Janus kinase 2	Homo sapiens	47-51
16550606-5	2006	At physiological concentrations (2.5 microM), curcumin rapidly inhibited phosphorylation of the mammalian target of rapamycin (mTOR) and its downstream effector molecules, p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), in a panel of cell lines (Rh1, Rh30, DU145, MCF-7 and Hela).	Curcumin	46-54	eukaryotic translation initiation factor 4E	Homo sapiens	199-230
29438581-0	2018	Curcumin-Functionalized Ag/Ag2 O Nanocomposites: Efficient Visible-Light Z-scheme Photocatalysts.	Curcumin	0-8	chromosome 11 open reading frame 96	Homo sapiens	27-30
29438581-1	2018	Curcumin-functionalized Ag/Ag2 O (c-Ag/Ag2 O) nanocomposites with varying proportions of curcumin and Ag/Ag2 O were prepared by a simple one pot green synthesis protocol in aqueous medium.	Curcumin	0-8	chromosome 11 open reading frame 96	Homo sapiens	27-30
16624471-3	2006	Here, we demonstrate that curcumin can induce apoptotic changes, including JNK activation, caspase-3 activation, and cleavage of PARP and PAK2, at treatment concentrations lower than 25 microM in human osteoblast cells.	Curcumin	26-34	collagen type XI alpha 2 chain	Homo sapiens	129-133
29438581-1	2018	Curcumin-functionalized Ag/Ag2 O (c-Ag/Ag2 O) nanocomposites with varying proportions of curcumin and Ag/Ag2 O were prepared by a simple one pot green synthesis protocol in aqueous medium.	Curcumin	0-8	chromosome 11 open reading frame 96	Homo sapiens	39-42
16624471-3	2006	Here, we demonstrate that curcumin can induce apoptotic changes, including JNK activation, caspase-3 activation, and cleavage of PARP and PAK2, at treatment concentrations lower than 25 microM in human osteoblast cells.	Curcumin	26-34	p21 (RAC1) activated kinase 2	Homo sapiens	138-142
29438581-1	2018	Curcumin-functionalized Ag/Ag2 O (c-Ag/Ag2 O) nanocomposites with varying proportions of curcumin and Ag/Ag2 O were prepared by a simple one pot green synthesis protocol in aqueous medium.	Curcumin	0-8	chromosome 11 open reading frame 96	Homo sapiens	39-42
29751106-6	2018	Curcumin significantly induced HMOX1 in single cell type models and co-cultures.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	31-36
29751106-9	2018	In the ZR-75-1/CLC co-culture, curcumin significantly down-regulated PEG10, an anti-apoptotic protein, and induced RRAGA, a pro-apoptotic protein involved in TNF-alpha signaling.	Curcumin	31-39	Ras related GTP binding A	Homo sapiens	115-120
16819191-0	2006	Curcumin decreases binding of Shiga-like toxin-1B on human intestinal epithelial cell line HT29 stimulated with TNF-alpha and IL-1beta: suppression of p38, JNK and NF-kappaB p65 as potential targets.	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	174-177
29899429-6	2018	Curcumin suppressed eIF2alpha phosphorylation, which is induced by endoplasmic reticulum (ER) stress, macrophage accumulation and nuclear factor-kappaB (NF-kappaB) p65 and leptin expression, whereas it"s anti-inflammatory effect was inadequate to decrease TNF-alpha and IFN-gamma levels.	Curcumin	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	164-167
29899429-7	2018	Lipidomic and gene expression analysis revealed that curcumin decreased some diacylglycerols (DAGs) and DAG-derived glycerophospholipids levels by suppressing the glycerol-3-phosphate acyltransferase 1 and adipose triglyceride lipase expression, which are associated with lipogenesis and lipolysis, respectively.	Curcumin	53-61	patatin-like phospholipase domain containing 2	Mus musculus	206-233
16819191-6	2006	Additionally, curcumin was able to inhibit mitogen-activated protein kinases (MAPKs), such as p38 and JNK, but not ERK1/2, degradation of IkappaB or translocation of NF-kappaB p65.	Curcumin	14-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	176-179
31032585-12	2018	Curcumin can up-regulate expression of Nrf2 and HO-1, effectively alleviates oxidative stress induced by overtraining, thereby increasing Bcl-2 expression, decreasing Bax expression, inhibiting renal apoptosis and protecting renal tissue structure and function properly.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	167-170
16751071-6	2006	Additionally, curcumin significantly decreased mRNA expression of early responding cytokines (IL-1 IL-6, IL-18, TNF-alpha, and lymphotoxin-beta) and the fibrogenic cytokine, TGF-beta, in cutaneous tissues at 21 days postradiation.	Curcumin	14-22	interleukin 1 complex	Mus musculus	94-103
29294495-0	2018	Synergistic Effect of Free and Nano-encapsulated Chrysin-Curcumin on Inhibition of hTERT Gene Expression in SW480 Colorectal Cancer Cell Line.	Curcumin	57-65	telomerase reverse transcriptase	Homo sapiens	83-88
29294495-9	2018	Also, real time-PCR showed significant decrease in hTERT gene expression in SW480 cells that treated with nano-curcumin and nano-chrysin compare to untreated cells.	Curcumin	111-119	telomerase reverse transcriptase	Homo sapiens	51-56
16751071-6	2006	Additionally, curcumin significantly decreased mRNA expression of early responding cytokines (IL-1 IL-6, IL-18, TNF-alpha, and lymphotoxin-beta) and the fibrogenic cytokine, TGF-beta, in cutaneous tissues at 21 days postradiation.	Curcumin	14-22	interleukin 18	Mus musculus	105-110
16751071-6	2006	Additionally, curcumin significantly decreased mRNA expression of early responding cytokines (IL-1 IL-6, IL-18, TNF-alpha, and lymphotoxin-beta) and the fibrogenic cytokine, TGF-beta, in cutaneous tissues at 21 days postradiation.	Curcumin	14-22	transforming growth factor, beta 1	Mus musculus	174-182
16628653-8	2006	Notch-1, Hes-1, and Bcl-XL expression levels concomitantly were down-regulated by curcumin treatment.	Curcumin	82-90	hes family bHLH transcription factor 1	Homo sapiens	9-14
16306131-0	2006	Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor.	Curcumin	0-8	cellular communication network factor 2	Homo sapiens	134-165
28681665-0	2018	Stimulatory effects of curcumin and quercetin on posttranslational modifications of p53 during lung carcinogenesis.	Curcumin	23-31	transformation related protein 53, pseudogene	Mus musculus	84-87
16306131-8	2006	We hypothesize that inhibition of alphaI(I)-collagen gene expression in HSCs by curcumin is mediated by suppressing CTGF gene expression through attenuating oxidative stress and interrupting TGF-beta signaling.	Curcumin	80-88	cellular communication network factor 2	Homo sapiens	116-120
28681665-5	2018	Curcumin and quercetin when administered individually as well as in combination significantly elevated the expression of acetylated-p53, which was otherwise depressed due to BP treatment.	Curcumin	0-8	transformation related protein 53, pseudogene	Mus musculus	132-135
28681665-9	2018	The present study concludes that prophylactic treatment with curcumin and quercetin induces apoptosis in the lungs by modulation of p53 posttranslational modifications.	Curcumin	61-69	transformation related protein 53, pseudogene	Mus musculus	132-135
16306131-9	2006	The present report demonstrated that curcumin significantly reduced the abundance of CTGF in passaged HSCs and suppressed its gene expression.	Curcumin	37-45	cellular communication network factor 2	Homo sapiens	85-89
29901626-14	2018	Moreover, curcumin significantly increased inositol-requiring enzyme 1alpha (IRE1alpha) phosphorylation and XBP-1 mRNA splicing to induce a subsets of ER chaperones.	Curcumin	10-18	X-box binding protein 1	Homo sapiens	108-113
16306131-10	2006	Exogenous CTGF dose dependently abrogated the inhibitory effect of curcumin.	Curcumin	67-75	cellular communication network factor 2	Homo sapiens	10-14
29582250-6	2018	Nonsteroidal anti-inflammatory drugs, curcumin, antipsychotic drugs, adiponectin, and sulforaphane downregulate the WNT/beta-catenin pathway through the upregulation of PPAR-gamma and thus appear to provide an interesting therapeutic approach for gliomas.	Curcumin	38-46	catenin beta 1	Homo sapiens	120-132
29844464-0	2018	Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1alpha inhibition.	Curcumin	0-8	pyruvate kinase M1/2	Homo sapiens	69-87
16306131-11	2006	Activation of PPAR-gamma by curcumin resulted in the interruption of TGF-beta signaling by suppressing gene expression of TGF-beta receptors, leading to inhibition of CTGF gene expression.	Curcumin	28-36	cellular communication network factor 2	Homo sapiens	167-171
29844464-3	2018	Herein, we show that curcumin inhibits glucose uptake and lactate production (Warburg effect) in a variety of cancer cell lines by down-regulating PKM2 expression, via inhibition of mTOR-HIF1alpha axis.	Curcumin	21-29	pyruvate kinase M1/2	Homo sapiens	147-151
29844464-5	2018	PKM2 over-expression abrogated the effects of curcumin, demonstrating that inhibition of Warburg effect by curcumin is PKM2-mediated.	Curcumin	46-54	pyruvate kinase M1/2	Homo sapiens	0-4
16306131-14	2006	Taken together, our results demonstrate that inhibition of alphaI(I)-collagen gene expression by curcumin in activated HSCs results from suppression of CTGF gene expression through increasing cellular GSH contents and interruption of TGF-beta signaling.	Curcumin	97-105	cellular communication network factor 2	Homo sapiens	152-156
29844464-5	2018	PKM2 over-expression abrogated the effects of curcumin, demonstrating that inhibition of Warburg effect by curcumin is PKM2-mediated.	Curcumin	46-54	pyruvate kinase M1/2	Homo sapiens	119-123
16779518-7	2006	Curcumin-treated mice also exhibited relative decreases in aortic tissue activator protein-1 and nuclear factor kappaB DNA binding activities and significantly lower aortic tissue concentrations of interleukin-1beta (IL-1beta), IL-6, monocyte chemoattractant protein-1, and matrix metalloproteinase-9 (all p &lt; 0.05).	Curcumin	0-8	jun proto-oncogene	Mus musculus	73-92
29844464-5	2018	PKM2 over-expression abrogated the effects of curcumin, demonstrating that inhibition of Warburg effect by curcumin is PKM2-mediated.	Curcumin	107-115	pyruvate kinase M1/2	Homo sapiens	0-4
29844464-5	2018	PKM2 over-expression abrogated the effects of curcumin, demonstrating that inhibition of Warburg effect by curcumin is PKM2-mediated.	Curcumin	107-115	pyruvate kinase M1/2	Homo sapiens	119-123
29844464-7	2018	The study unravels novel PKM2-mediated inhibitory effect of curcumin on metabolic capacities of cancer cells.	Curcumin	60-68	pyruvate kinase M1/2	Homo sapiens	25-29
29844464-8	2018	To the best of our knowledge, this is the first study linking curcumin with PKM2-driven cancer glycolysis, thus, providing new perspectives into the mechanism of its anticancer activity.	Curcumin	62-70	pyruvate kinase M1/2	Homo sapiens	76-80
29801408-8	2018	Theresults showed that administration of curcumin in all the dose administered were incapable improving the expressionsof vimentin, TGF-beta1 and E-cadherin.	Curcumin	41-49	vimentin	Homo sapiens	122-130
16779518-7	2006	Curcumin-treated mice also exhibited relative decreases in aortic tissue activator protein-1 and nuclear factor kappaB DNA binding activities and significantly lower aortic tissue concentrations of interleukin-1beta (IL-1beta), IL-6, monocyte chemoattractant protein-1, and matrix metalloproteinase-9 (all p &lt; 0.05).	Curcumin	0-8	matrix metallopeptidase 9	Mus musculus	274-300
30693689-6	2018	RESULTS: Compared with MPTP model group, curcumin increased the number of surviving dopamine neurons(P<0.01), decreased both protein expression and mRNA expression of alpha-Syn (all P<0.01), and increased protein expression of TFEB, LAMP2A and LC3-II (all P<0.01).	Curcumin	41-49	synuclein alpha	Homo sapiens	167-176
16288471-8	2006	Most surprisingly, VCAM-1 expression was also significantly blocked by a selective inhibitor of p300, curcumin.	Curcumin	102-110	E1A binding protein p300	Homo sapiens	96-100
30693689-7	2018	When curcumin and 3-MA were given concurrently, the number of surviving dopamine neurons, protein expression of TFEB, LAMP2A and LC3-II increased (P<0.05 or P<0.01), and both protein expression and mRNA expression of alpha-Syn decreased (P<0.05 or P<0.01) compared with MPTP model group; but the number of surviving dopamine neurons and protein expression of LAMP2A and LC3-II decreased compared with curcumin group (all P<0.05).	Curcumin	5-13	synuclein alpha	Homo sapiens	217-226
30693689-8	2018	CONCLUSIONS: Curcumin exerts protective effect on dopamine neurons in PD, which may be associated with enhancing autophagy and promoting the clearance of alpha-Syn.	Curcumin	13-21	synuclein alpha	Homo sapiens	154-163
29938678-8	2018	Co-treatment with curcumin markedly reduced apoptosis and ROS production, together with increased MMP and Bcl2/Bax protein ratio.	Curcumin	18-26	BCL2 associated X, apoptosis regulator	Rattus norvegicus	111-114
16157375-0	2006	Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines.	Curcumin	0-8	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	47-51
16157375-0	2006	Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines.	Curcumin	0-8	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-77
29616136-10	2018	Furthermore, curcumin-related cell death in HL-60 was associated with the processed forms of caspases-9 and -3 proteins, whereas in K562 cells, both the processed and the unprocessed forms were present.	Curcumin	13-21	caspase 9	Homo sapiens	93-110
16157375-3	2006	In this study, we examined the effects of curcumin on AP-1 activity in HTLV-1-infected T-cell lines.	Curcumin	42-50	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	54-58
16722385-4	2006	Three curcumin (16.5,33,66 micromol x L(-1)) could obviously activate the expression of LDLR of VSMC.	Curcumin	6-14	low density lipoprotein receptor	Bos taurus	88-92
29566233-10	2018	Curcumin supplementation attenuated the depression of the thioredoxin 2 and peroxiredoxin-3 gene expressions (P &lt; 0.05).	Curcumin	0-8	peroxiredoxin 3	Gallus gallus	76-91
29420338-9	2018	After curcumin treatment, drug-resistant cell proliferation was significantly inhibited; in the curcumin+irinotecan treatment group, E-cadherin expression was upregulated, whereas vimentin and N-cadherin expressions were downregulated.	Curcumin	6-14	vimentin	Homo sapiens	180-188
29242172-5	2018	Curcumin up-regulated mRNA expression of genes involved in cholesterol transport and metabolism as ATP-binding cassette (ABC) transporters ABCA1 and ABCG1, and the sterol response element binding protein 1c (SREBP1c).	Curcumin	0-8	sterol regulatory element binding transcription factor 1	Homo sapiens	164-206
29242172-5	2018	Curcumin up-regulated mRNA expression of genes involved in cholesterol transport and metabolism as ATP-binding cassette (ABC) transporters ABCA1 and ABCG1, and the sterol response element binding protein 1c (SREBP1c).	Curcumin	0-8	sterol regulatory element binding transcription factor 1	Homo sapiens	208-215
16722385-5	2006	CONCLUSION: The three different structural curcumin pigmen monomers can not only inhibit the proliferation of bovine VSMC obviously stimulated by ox-LDL, but also promote the expression of LDL-R on bovine VSMC, that may be the mechanism of delaying the development of arteriosclerosis.	Curcumin	43-51	low density lipoprotein receptor	Bos taurus	189-194
16210389-5	2006	Curcumin (10(-8) mol/l), a known nuclear factor (NF)-kappaB inhibitor, inhibited the TNF-alpha-induced pIkappaB phosphorylation as shown by western blotting, NF-kappaB translocation into the nucleus as shown by electrophoretic mobility shift assay, and MIF synthesis and secretion as measured by ELISA and RT-PCR.	Curcumin	0-8	macrophage migration inhibitory factor	Homo sapiens	253-256
17341208-0	2006	Curcumin, a potential inhibitor of MMP-2 in human laryngeal squamous carcinoma cells HEp2.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	35-40
29393445-7	2018	Inhibition of the JAK2/STAT3 signaling pathway, such as curcumin can reduce the expression of HMGB1 in brain tissue after cerebral ischemia, which can significantly reduce the inflammatory response after cerebral ischemia.	Curcumin	56-64	signal transducer and activator of transcription 3	Rattus norvegicus	23-28
29436680-0	2018	Curcumin increases cholesterol efflux via heme oxygenase-1-mediated ABCA1 and SR-BI expression in macrophages.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	42-58
29436680-9	2018	Additionally, curcumin significantly upregulated HO-1 expression.	Curcumin	14-22	heme oxygenase 1	Homo sapiens	49-53
29436680-12	2018	HO-1 small interfering (si)RNA partly abolished the increased SR-BI and ABCA1 expression induced by curcumin.	Curcumin	100-108	heme oxygenase 1	Homo sapiens	0-4
29436680-14	2018	Nrf2 siRNA successfully inhibited the curcumin-induced HO-1 expression.	Curcumin	38-46	heme oxygenase 1	Homo sapiens	55-59
29436680-16	2018	Overall, these data indicated that curcumin activates the Nrf2-ARE signaling pathway and upregulates HO-1 expression, which mediates SR-BI and ABCA1 expression and thereby increases cholesterol efflux.	Curcumin	35-43	heme oxygenase 1	Homo sapiens	101-105
29460119-9	2018	These results could shed light on understanding of the molecular basis for the inhibition of Curcumin on MCP-1 expression during the process of astrocyte activation, and provide a molecular mechanism for using Curcumin in neuropathic pain.	Curcumin	93-101	C-C motif chemokine ligand 2	Homo sapiens	105-110
29703905-6	2018	microCT analysis showed that local administration of curcumin resulted in a complete inhibition of inflammatory bone resorption and in a significant decrease of both osteoclast counts and of the inflammatory infiltrate; as well as a marked attenuation of p38 MAPK and NF-kB activation.	Curcumin	53-61	nuclear factor kappa B subunit 1	Rattus norvegicus	268-273
29408622-5	2018	Finally, we detected the expression of CDKN1A, CTGF, LEF1 TF and MIR-19A regulated by curcumin in PLC/PRF/5 cells using RT-PCR.	Curcumin	86-94	microRNA 19a	Homo sapiens	65-72
29408622-5	2018	Finally, we detected the expression of CDKN1A, CTGF, LEF1 TF and MIR-19A regulated by curcumin in PLC/PRF/5 cells using RT-PCR.	Curcumin	86-94	heparan sulfate proteoglycan 2	Homo sapiens	98-101
29408622-12	2018	Furthermore, the expression of CDKN1A, CTGF, LEF1 TF and miR-19A regulated by curcumin in PLC/PRF/5 cells was consistent with the aforementioned bioinformatics analysis results.	Curcumin	78-86	microRNA 19a	Homo sapiens	57-64
29408622-12	2018	Furthermore, the expression of CDKN1A, CTGF, LEF1 TF and miR-19A regulated by curcumin in PLC/PRF/5 cells was consistent with the aforementioned bioinformatics analysis results.	Curcumin	78-86	heparan sulfate proteoglycan 2	Homo sapiens	90-93
29408622-13	2018	To conclude, curcumin might exert its protective effects against HCC tumorigenesis by downregulating LEF1 and downregulating CTGF regulated by MIR-19A and upregulating CDKN1A expression.	Curcumin	13-21	microRNA 19a	Homo sapiens	143-150
29657313-12	2018	Moreover, the phosphorylation levels of mitogen-activated protein kinase (MAPK) kinase 4 (MKK4), MKK7, and c-Jun NH(2)-terminal protein kinase (JNK) were reduced by curcumin pre-treatment.	Curcumin	165-173	mitogen-activated protein kinase 8	Rattus norvegicus	107-142
29657313-12	2018	Moreover, the phosphorylation levels of mitogen-activated protein kinase (MAPK) kinase 4 (MKK4), MKK7, and c-Jun NH(2)-terminal protein kinase (JNK) were reduced by curcumin pre-treatment.	Curcumin	165-173	mitogen-activated protein kinase 8	Rattus norvegicus	144-147
29549176-0	2018	Curcumin Suppresses IL-1beta Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	91-96
29549176-5	2018	The inhibitory effect of curcumin on inflammasome activation was specific to the NLRP3, not to the NLRC4 or the AIM2 inflammasomes.	Curcumin	25-33	NLR family, pyrin domain containing 3	Mus musculus	81-86
29549176-6	2018	Curcumin inhibited the NLRP3 inflammasome by preventing K+ efflux and disturbing the downstream events, including the efficient spatial arrangement of mitochondria, ASC oligomerization, and speckle formation.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	23-28
29549176-10	2018	Taken together, we identified curcumin as a common NLRP3 inflammasome activation inhibitor.	Curcumin	30-38	NLR family, pyrin domain containing 3	Mus musculus	51-56
29549176-11	2018	Our findings reveal a mechanism through which curcumin represses inflammation and suggest the potential clinical use of curcumin in NLRP3-driven diseases.	Curcumin	120-128	NLR family, pyrin domain containing 3	Mus musculus	132-137
29615146-0	2018	Curcumin suppress the growth of hepatocellular carcinoma via down-regulating SREBF1.	Curcumin	0-8	sterol regulatory element binding transcription factor 1	Homo sapiens	77-83
29615146-5	2018	Retrieval in gene expression database and related gene-drug network analysis showed that the effect of curcumin on the apoptosis of HCC cells was related to SREBF1 (sterol regulatory element binding transcription factor 1) gene.	Curcumin	103-111	sterol regulatory element binding transcription factor 1	Homo sapiens	157-163
29615146-5	2018	Retrieval in gene expression database and related gene-drug network analysis showed that the effect of curcumin on the apoptosis of HCC cells was related to SREBF1 (sterol regulatory element binding transcription factor 1) gene.	Curcumin	103-111	sterol regulatory element binding transcription factor 1	Homo sapiens	165-221
29615146-6	2018	In the in-vitro experiment, adding curcumin could significantly down-regulate SREBF1, and Western Blot suggested that down-regulation of SREBF1 could suppress the tumor growth.	Curcumin	35-43	sterol regulatory element binding transcription factor 1	Homo sapiens	78-84
29615146-6	2018	In the in-vitro experiment, adding curcumin could significantly down-regulate SREBF1, and Western Blot suggested that down-regulation of SREBF1 could suppress the tumor growth.	Curcumin	35-43	sterol regulatory element binding transcription factor 1	Homo sapiens	137-143
29615146-7	2018	In conclusion, Curcumin could significantly suppress the tumor growth by way of down-regulating SREBF1 expression.	Curcumin	15-23	sterol regulatory element binding transcription factor 1	Homo sapiens	96-102
29191105-3	2018	Curcumin dose-dependently inhibited TCDD-induced expression of phase I enzyme cytochrome P450 1A1 (CYP1A1) and phase II enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase 1 (HO-1) but not tert-butyl hydroquinone-induced NQO1 and HO-1, suggesting that curcumin inhibited only AhR pathway, but not Nrf2 one directly.	Curcumin	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	78-97
29191105-3	2018	Curcumin dose-dependently inhibited TCDD-induced expression of phase I enzyme cytochrome P450 1A1 (CYP1A1) and phase II enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase 1 (HO-1) but not tert-butyl hydroquinone-induced NQO1 and HO-1, suggesting that curcumin inhibited only AhR pathway, but not Nrf2 one directly.	Curcumin	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	99-105
29191105-3	2018	Curcumin dose-dependently inhibited TCDD-induced expression of phase I enzyme cytochrome P450 1A1 (CYP1A1) and phase II enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase 1 (HO-1) but not tert-butyl hydroquinone-induced NQO1 and HO-1, suggesting that curcumin inhibited only AhR pathway, but not Nrf2 one directly.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	172-188
29191105-3	2018	Curcumin dose-dependently inhibited TCDD-induced expression of phase I enzyme cytochrome P450 1A1 (CYP1A1) and phase II enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase 1 (HO-1) but not tert-butyl hydroquinone-induced NQO1 and HO-1, suggesting that curcumin inhibited only AhR pathway, but not Nrf2 one directly.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	190-194
29191105-3	2018	Curcumin dose-dependently inhibited TCDD-induced expression of phase I enzyme cytochrome P450 1A1 (CYP1A1) and phase II enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase 1 (HO-1) but not tert-butyl hydroquinone-induced NQO1 and HO-1, suggesting that curcumin inhibited only AhR pathway, but not Nrf2 one directly.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	245-249
17341208-5	2006	RESULTS: Treatment of HEp2 cells with curcumin downregulated MMP-2 expression and activity and expression of integrin receptors, FAK, and MT1-MMP to almost background levels.	Curcumin	38-46	matrix metallopeptidase 2	Homo sapiens	61-66
17341208-5	2006	RESULTS: Treatment of HEp2 cells with curcumin downregulated MMP-2 expression and activity and expression of integrin receptors, FAK, and MT1-MMP to almost background levels.	Curcumin	38-46	protein tyrosine kinase 2	Homo sapiens	129-132
17341208-5	2006	RESULTS: Treatment of HEp2 cells with curcumin downregulated MMP-2 expression and activity and expression of integrin receptors, FAK, and MT1-MMP to almost background levels.	Curcumin	38-46	matrix metallopeptidase 14	Homo sapiens	138-145
17341208-6	2006	MMP-2 (but not MMP-9) mRNA expression was abolished on curcumin treatment, indicating specific inhibition of MMP-2.	Curcumin	55-63	matrix metallopeptidase 2	Homo sapiens	0-5
17341208-6	2006	MMP-2 (but not MMP-9) mRNA expression was abolished on curcumin treatment, indicating specific inhibition of MMP-2.	Curcumin	55-63	matrix metallopeptidase 2	Homo sapiens	109-114
17341208-11	2006	Reduction of MMP-2 activity and inhibition of HEp2 cell invasion by curcumin strongly indicate the potential of curcumin as an inhibitor of tumor cell invasion and metastasis.	Curcumin	112-120	matrix metallopeptidase 2	Homo sapiens	13-18
16219905-10	2006	We found that curcumin suppressed TNF-induced nuclear translocation of p65, which corresponded with the sequential suppression of IkappaBalpha kinase activity, IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation, p65 nuclear translocation, and p65 acetylation.	Curcumin	14-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	71-74
16389264-7	2006	Curcumin treatment resulted not only in a significant reduction in the expression of MMP-2 and MMP-9, but also effected the inhibition of invasive ability in vitro.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	85-90
16389264-8	2006	Curcumin was shown to induce a marked reduction of tumor volume, MMP-2, and MMP-9 activity in the tumor-bearing site.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	65-70
16243823-5	2005	Curcumin also suppressed the paclitaxel-induced expression of antiapoptotic (XIAP, IAP-1, IAP-2, Bcl-2, and Bcl-xL), proliferative (cyclooxygenase 2, c-Myc, and cyclin D1), and metastatic proteins (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1).	Curcumin	0-8	baculoviral IAP repeat containing 2	Homo sapiens	90-95
16243823-5	2005	Curcumin also suppressed the paclitaxel-induced expression of antiapoptotic (XIAP, IAP-1, IAP-2, Bcl-2, and Bcl-xL), proliferative (cyclooxygenase 2, c-Myc, and cyclin D1), and metastatic proteins (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1).	Curcumin	0-8	cyclin D1	Homo sapiens	161-170
16173963-7	2005	BAY 11-7082- and curcumin-induced cell death was associated with downregulation of Bcl-xL, cyclin D1, XIAP and c-FLIP, followed by caspase-8, poly(ADP-ribose) polymerase cleavage and activation.	Curcumin	17-25	caspase 8	Homo sapiens	131-140
15901641-6	2005	Curcumin (10(-8) M), which is known for inhibiting NFkappaB activation, inhibited IL1B-induced MIF secretion as well as NFkappaB nuclear translocation and DNA binding.	Curcumin	0-8	macrophage migration inhibitory factor	Homo sapiens	95-98
16153429-11	2005	Furthermore, curcumin (5 and 10 microM) in combination with CRP (10 microg/mL) significantly increased TM mRNA levels by 45 and 100%, respectively, and increased EPCR mRNA levels by 24 and 45%, respectively, compared with those in CRP-treated cells (P &lt; .05).	Curcumin	13-21	protein C receptor	Homo sapiens	162-166
29162464-2	2018	Curcumin bound to the purified Eg5 (Eg5-437H) with a Kd value of 7.8muM.	Curcumin	0-8	kinesin family member 11	Homo sapiens	36-44
29162464-4	2018	Evidences from competition experiment with monastrol indicated that curcumin bound to Eg5 at a novel druggable site.	Curcumin	68-76	kinesin family member 11	Homo sapiens	86-89
16153429-14	2005	Curcumin completely blocks CRP-induced downregulation of TM and EPCR in HCAECs.	Curcumin	0-8	protein C receptor	Homo sapiens	64-68
29162464-5	2018	Using Forster resonance energy transfer the distance between curcumin and monastrol binding site from TRP127 on Eg5-437H was found to be 33A and 17A respectively.	Curcumin	61-69	kinesin family member 11	Homo sapiens	112-120
15893313-7	2005	In the present study, we demonstrate that curcumin and its derivative are excellent inhibitors of beta-catenin/Tcf signaling in all tested cancer cell lines and the reduced beta-catenin/Tcf transcriptional activity is due to the decreased nuclear beta-catenin and Tcf-4.	Curcumin	42-50	transcription factor 4	Homo sapiens	264-269
29162464-6	2018	Curcumin inhibited the ATPase activity of Eg5 motor and perturbed the dynamic interactions between Eg5 and microtubules.	Curcumin	0-8	kinesin family member 11	Homo sapiens	42-45
29162464-6	2018	Curcumin inhibited the ATPase activity of Eg5 motor and perturbed the dynamic interactions between Eg5 and microtubules.	Curcumin	0-8	kinesin family member 11	Homo sapiens	99-102
29162464-7	2018	Results from circular dichroism studies and molecular dynamics simulations suggest that curcumin binding might perturb the Eg5-437H secondary structure which could be the reason behind its inhibitory effects on Eg5.	Curcumin	88-96	kinesin family member 11	Homo sapiens	123-131
15486348-9	2005	In addition to curcumin reduction of the level of phosphorylated PPARgamma, inhibition of cyclin D1 expression played a major and significant role in curcumin stimulation of PPARgamma activity in Moser cells.	Curcumin	150-158	cyclin D1	Homo sapiens	90-99
29162464-7	2018	Results from circular dichroism studies and molecular dynamics simulations suggest that curcumin binding might perturb the Eg5-437H secondary structure which could be the reason behind its inhibitory effects on Eg5.	Curcumin	88-96	kinesin family member 11	Homo sapiens	123-126
29460119-0	2018	Curcumin Inhibits Monocyte Chemoattractant Protein-1 Expression in TNF-alpha induced Astrocytes Through AMPK Pathway.	Curcumin	0-8	C-C motif chemokine ligand 2	Homo sapiens	18-52
15486348-10	2005	Taken together, our results demonstrated for the first time that curcumin activation of PPARgamma inhibited Moser cell growth and mediated the suppression of the gene expression of cyclin D1 and EGFR.	Curcumin	65-73	cyclin D1	Homo sapiens	181-190
29460119-6	2018	Our data demonstrated that Curcumin inhibited TNF-alpha-induced astrocytes migration, decreased MCP-1 expression, and up-regulated SOD2 expression in TNF-alpha-induced astrocytes in vitro.	Curcumin	27-35	C-C motif chemokine ligand 2	Homo sapiens	96-101
15733976-0	2005	Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells.	Curcumin	25-33	protein C receptor	Homo sapiens	74-104
15733976-1	2005	The objective of this study was to elucidate the effects of tumor necrosis factor-alpha (TNF-alpha) on the expression of thrombomodulin (TM) and endothelial protein C receptor (EPCR) in human endothelial cells as well as the effect of curcumin, a spice and coloring food compound, as a potential therapeutic agent.	Curcumin	235-243	protein C receptor	Homo sapiens	177-181
15733976-8	2005	Curcumin effectively blocked these effects of TNF-alpha on downregulation of TM and EPCR.	Curcumin	0-8	protein C receptor	Homo sapiens	84-88
29466778-2	2018	The natural product curcumin is reported to inhibit the TLR4 co-receptor, MD2 (myeloid differentiation protein 2), but its low in vivo bioavailability limits its therapeutic potential.	Curcumin	20-28	toll like receptor 4	Homo sapiens	56-60
15383533-0	2004	Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription.	Curcumin	0-8	E1A binding protein p300	Homo sapiens	18-83
29139094-13	2018	CONCLUSION: Curcumin might have therapeutic potential in breast cancer through regulating breast cancer-related genes, including SERPINE1, PGAP3, MAP3K1, MAPK1, GSTO2, VIM, SPARC, and FGF2.	Curcumin	12-20	serpin family E member 1	Homo sapiens	129-137
15383533-4	2004	In this study, we report that curcumin (diferuloylmethane), a major curcumanoid in the spice turmeric, is a specific inhibitor of the p300/CREB-binding protein (CBP) HAT activity but not of p300/CBP-associated factor, in vitro and in vivo.	Curcumin	30-38	E1A binding protein p300	Homo sapiens	134-138
29139094-13	2018	CONCLUSION: Curcumin might have therapeutic potential in breast cancer through regulating breast cancer-related genes, including SERPINE1, PGAP3, MAP3K1, MAPK1, GSTO2, VIM, SPARC, and FGF2.	Curcumin	12-20	post-GPI attachment to proteins phospholipase 3	Homo sapiens	139-144
29454324-8	2018	The expression levels of HSP70 and the activities of 8-OHdG and MDA in the curcumin group were decreased compared with those in the model group, whereas the activities of CAT, SOD, and GSH-Px were significantly higher than those in the model group (P &lt; 0.05).	Curcumin	75-83	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	25-30
29454324-10	2018	Correspondingly, the mRNA expression of caspase-3, Bax, and Cox-2 was lower in the curcumin group than in the model group (P &lt; 0.05).	Curcumin	83-91	BCL2 associated X, apoptosis regulator	Rattus norvegicus	51-54
15383533-4	2004	In this study, we report that curcumin (diferuloylmethane), a major curcumanoid in the spice turmeric, is a specific inhibitor of the p300/CREB-binding protein (CBP) HAT activity but not of p300/CBP-associated factor, in vitro and in vivo.	Curcumin	30-38	E1A binding protein p300	Homo sapiens	190-194
15383533-4	2004	In this study, we report that curcumin (diferuloylmethane), a major curcumanoid in the spice turmeric, is a specific inhibitor of the p300/CREB-binding protein (CBP) HAT activity but not of p300/CBP-associated factor, in vitro and in vivo.	Curcumin	40-57	E1A binding protein p300	Homo sapiens	134-138
15383533-4	2004	In this study, we report that curcumin (diferuloylmethane), a major curcumanoid in the spice turmeric, is a specific inhibitor of the p300/CREB-binding protein (CBP) HAT activity but not of p300/CBP-associated factor, in vitro and in vivo.	Curcumin	40-57	E1A binding protein p300	Homo sapiens	190-194
15383533-5	2004	Furthermore, curcumin could also inhibit the p300-mediated acetylation of p53 in vivo.	Curcumin	13-21	E1A binding protein p300	Homo sapiens	45-49
15383533-7	2004	It is significant that curcumin could inhibit the acetylation of HIV-Tat protein in vitro by p300 as well as proliferation of the virus, as revealed by the repression in syncytia formation upon curcumin treatment in SupT1 cells.	Curcumin	23-31	E1A binding protein p300	Homo sapiens	93-97
15383533-8	2004	Thus, non-toxic curcumin, which targets p300/CBP, may serve as a lead compound in combinatorial HIV therapeutics.	Curcumin	16-24	E1A binding protein p300	Homo sapiens	40-44
15582125-7	2004	Curcumin prevented the MCD-induced activation of NF-kappaB and decreased downstream induction of ICAM-1, COX-2 and MCP-1.	Curcumin	0-8	intercellular adhesion molecule 1	Mus musculus	97-103
29374713-0	2018	Maspin Enhances the Anticancer Activity of Curcumin in Hormone-refractory Prostate Cancer Cells.	Curcumin	43-51	serpin family B member 5	Homo sapiens	0-6
15582125-7	2004	Curcumin prevented the MCD-induced activation of NF-kappaB and decreased downstream induction of ICAM-1, COX-2 and MCP-1.	Curcumin	0-8	cytochrome c oxidase II, mitochondrial	Mus musculus	105-110
29374713-3	2018	However, the role of maspin on the anticancer activity of curcumin derived from turmeric (Curcuma longa) in HRPC cells has not been elucidated.	Curcumin	58-66	serpin family B member 5	Homo sapiens	21-27
15203111-5	2004	These findings provided evidence that curcumin was found to protect rat myocardium against ischaemic insult and the protective effect could be attributed to its antioxidant properties as well as its inhibitory effects on xanthine dehydrogenase/xanthine oxidase (XD/XO) conversion and resultant superoxide anion production.	Curcumin	38-46	xanthine dehydrogenase	Rattus norvegicus	221-243
29374713-5	2018	The cause of maspin silencing on the anti-tumor abilities of curcumin in PC-3 cells was evaluated by measures of cell survival rate, cell-cycle distribution, and apoptosis signaling analysis.	Curcumin	61-69	serpin family B member 5	Homo sapiens	13-19
29374713-6	2018	RESULTS: Our present study showed that PC-3 cells (with higher maspin expression) were more sensitive than DU145 cells to curcumin treatment (with lower maspin expression).	Curcumin	122-130	serpin family B member 5	Homo sapiens	153-159
29374713-7	2018	RNA interference-mediated maspin silencing reduced curcumin sensitivity of PC-3 cells, as evidenced by reduced apoptotic cell death.	Curcumin	51-59	serpin family B member 5	Homo sapiens	26-32
15194816-8	2004	The stretch-induced augmentation of both IL-8 and MCP-3 expression was significantly suppressed by an activator protein-1 (AP-1) inhibitor, curcumin.	Curcumin	140-148	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	102-121
29374713-8	2018	After exposure to curcumin, maspin-knockdown cells showed lower expression levels of pro-apoptotic proteins, Bad and Bax, as compared with control cells.	Curcumin	18-26	serpin family B member 5	Homo sapiens	28-34
29374713-9	2018	CONCLUSION: Maspin can enhance the sensitivity of HRPC cells to curcumin treatment.	Curcumin	64-72	serpin family B member 5	Homo sapiens	12-18
29207190-5	2018	For this purpose, PC3 and DU145 cells were treated with a series of curcumin analogs at 0-10 microM for 72 h and cytotoxicity was determined by the sulforhodamine B (SRB) assay.	Curcumin	68-76	proprotein convertase subtilisin/kexin type 1	Homo sapiens	18-21
29606874-3	2018	In this study, we prepared Fab" (antigen-binding fragments cut from TMAB)-modified NPs (Fab"-NPs) with curcumin (Cur) as a model drug for more effective targeting of human epidermal growth factor receptor 2 (HER2/ErbB2/Neu), which is overexpressed on breast cancer cells.	Curcumin	103-111	FA complementation group B	Homo sapiens	27-30
29606874-3	2018	In this study, we prepared Fab" (antigen-binding fragments cut from TMAB)-modified NPs (Fab"-NPs) with curcumin (Cur) as a model drug for more effective targeting of human epidermal growth factor receptor 2 (HER2/ErbB2/Neu), which is overexpressed on breast cancer cells.	Curcumin	103-111	FA complementation group B	Homo sapiens	88-91
15194816-8	2004	The stretch-induced augmentation of both IL-8 and MCP-3 expression was significantly suppressed by an activator protein-1 (AP-1) inhibitor, curcumin.	Curcumin	140-148	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-127
28935827-10	2018	IL-1RA increased more from Pre to 1-Post in Placebo (153%) than in Curcumin (77%).	Curcumin	67-75	interleukin 1 receptor antagonist	Homo sapiens	0-6
15193999-8	2004	The effect of FK960 on GDNF mRNA expression was attenuated by PD98059, curcumin (10microM), an activator protein-1 inhibitor, cycloheximide and actinomycin D (10microg/ml).	Curcumin	71-79	glial cell derived neurotrophic factor	Rattus norvegicus	23-27
28902433-0	2018	Curcumin alleviates IL-17A-mediated p53-PAI-1 expression in bleomycin-induced alveolar basal epithelial cells.	Curcumin	0-8	serpin family E member 1	Homo sapiens	40-45
29443732-0	2018	Curcumin induces apoptosis and inhibits proliferation in infantile hemangioma endothelial cells via downregulation of MCL-1 and HIF-1alpha.	Curcumin	0-8	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	118-123
29443732-6	2018	Moreover, we showed that curcumin suppressed the expression of antiapoptotic protein myeloid cell leukemia-1 (MCL-1), hypoxia-inducible factor 1alpha (HIF-1alpha), and vascular endothelial growth factor (VEGF).Altogether, our study suggests that the effectiveness of curcumin in IHs may be associated with its potent antiproliferative and apoptotic activities in HemECs.	Curcumin	25-33	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	85-108
29443732-6	2018	Moreover, we showed that curcumin suppressed the expression of antiapoptotic protein myeloid cell leukemia-1 (MCL-1), hypoxia-inducible factor 1alpha (HIF-1alpha), and vascular endothelial growth factor (VEGF).Altogether, our study suggests that the effectiveness of curcumin in IHs may be associated with its potent antiproliferative and apoptotic activities in HemECs.	Curcumin	25-33	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	110-115
29168312-0	2018	Curcumin mediated down-regulation of alphaV beta3 integrin and up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) in Erlotinib resistant SW480 colon cancer cells.	Curcumin	0-8	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	44-49
29168312-2	2018	To shed light on the erlotinib-resistant pathway, this study investigated the effect of combination therapy using curcumin- and erlotinib-loaded nanoparticles on the expression of alphav beta3 integrin and pyruvate dehydrogenase kinase 4 (PDK4) in an erlotinib-resistant SW480 colon cancer cell line.	Curcumin	114-122	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	187-192
29422835-0	2017	Nanoparticle-Encapsulated Curcumin Inhibits Diabetic Neuropathic Pain Involving the P2Y12 Receptor in the Dorsal Root Ganglia.	Curcumin	26-34	purinergic receptor P2Y12	Rattus norvegicus	84-89
29289745-10	2018	The highest visible light to electric conversion efficiency of 0.266% (using ITO) and 0.33% (using FTO) is achieved from the curcumin dye-sensitized cell.	Curcumin	125-133	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	99-102
29721078-2	2018	Curcumin holds the potential for alpha-synuclein clearance to treat PD; however, its applications are still limited due to its low bioavailability and poor permeability through the BBB in a free form.	Curcumin	0-8	synuclein alpha	Homo sapiens	33-48
29721078-6	2018	Notably, motor behaviors, dopamine (DA) level and tyrosine hydroxylase (TH) expression all returned to normal, thanks to alpha-synuclein (AS) removal mediated by efficient curcumin delivery to the striatum.	Curcumin	172-180	synuclein alpha	Homo sapiens	121-136
14701837-7	2004	Addition of curcumin to neuro 2a cells induces a rapid decrease in mitochondrial membrane potential and the release of cytochrome c into cytosol, followed by activation of caspase-9 and caspase-3.	Curcumin	12-20	caspase 9	Mus musculus	172-181
29325994-0	2018	The effects of melatonin and curcumin on the expression of SIRT2, Bcl-2 and Bax in the hippocampus of adult rats.	Curcumin	29-37	BCL2 associated X, apoptosis regulator	Rattus norvegicus	76-79
29328421-10	2018	Furthermore, the effect of curcumin on a substantial downregulation of phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway was observed.	Curcumin	27-35	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	71-100
29422835-7	2017	In the present study, our aim was to investigate the effects of nanoparticle-encapsulated curcumin on DNP mediated by the P2Y12 receptor on SGCs in the rat DRG.	Curcumin	90-98	purinergic receptor P2Y12	Rattus norvegicus	122-127
29422835-14	2017	Therefore, the nanoparticle-encapsulated curcumin treatment decreased the up-regulation of the P2Y12 receptor on SGCs in the DRG and decreased mechanical and thermal hyperalgesia in rats with DM.	Curcumin	41-49	purinergic receptor P2Y12	Rattus norvegicus	95-100
15037818-0	2004	Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor kappab bindings in BV2 microglial cells.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	47-63
29581972-9	2018	This was accompanied by an increase in caspase-3/caspase-7 activities after cell treatment with curcumin-nanoemulsion and Photodynamic Therapy, suggesting cell death by apoptosis.	Curcumin	96-104	caspase 7	Homo sapiens	49-58
29223538-8	2018	KEY FINDINGS: Curcumin increased the expression of genes such as distal-less homeobox 5 (Dlx5), runt-related transcription factor 2 (Runx2), ALP, and osteocalcin (OC), which subsequently induced osteoblast differentiation in C3H10T1/2 cells.	Curcumin	14-22	runt related transcription factor 2	Mus musculus	96-131
29773103-0	2018	[Curcumin alleviates early brain injury following subarachnoid hemorrhage in rats by inhibiting JNK/c-Jun signal pathway].	Curcumin	1-9	mitogen-activated protein kinase 8	Rattus norvegicus	96-99
29773103-1	2018	Objective To investigate the inhibitory effect of curcumin on early brain injury following subarachnoid hemorrhage (SAH) by inhibiting JNK/ c-Jun signal pathway.	Curcumin	50-58	mitogen-activated protein kinase 8	Rattus norvegicus	135-138
29773103-12	2018	Conclusion Curcumin might suppress early brain injury after SAH by inhibiting JNK/c-Jun signal pathway and neuron apoptosis.	Curcumin	11-19	mitogen-activated protein kinase 8	Rattus norvegicus	78-81
29223538-8	2018	KEY FINDINGS: Curcumin increased the expression of genes such as distal-less homeobox 5 (Dlx5), runt-related transcription factor 2 (Runx2), ALP, and osteocalcin (OC), which subsequently induced osteoblast differentiation in C3H10T1/2 cells.	Curcumin	14-22	runt related transcription factor 2	Mus musculus	133-138
15037818-0	2004	Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor kappab bindings in BV2 microglial cells.	Curcumin	0-8	jun proto-oncogene	Mus musculus	89-108
29223538-8	2018	KEY FINDINGS: Curcumin increased the expression of genes such as distal-less homeobox 5 (Dlx5), runt-related transcription factor 2 (Runx2), ALP, and osteocalcin (OC), which subsequently induced osteoblast differentiation in C3H10T1/2 cells.	Curcumin	14-22	bone gamma-carboxyglutamate protein 2	Mus musculus	150-161
29223538-13	2018	In addition, similar to BMP2, curcumin induced the phosphorylation of Smad 1/5/9.	Curcumin	30-38	SMAD family member 1	Mus musculus	70-80
29353037-0	2018	Curcumin protects cortical neurons against oxygen and glucose deprivation/reoxygenation injury through flotillin-1 and extracellular signal-regulated kinase1/2 pathway.	Curcumin	0-8	flotillin 1	Mus musculus	103-114
15037818-4	2004	Curcumin significantly inhibited LPS-mediated induction of COX-2 expression in both mRNA and protein levels in a concentration-dependent manner.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	59-64
28561324-7	2018	Curcumin further reduced adenine-induced hypertension, urinary albumin, the inflammatory cytokines IL-1beta, IL-6 and TNF-alpha, cystatin C and adiponectin.	Curcumin	0-8	cystatin C	Rattus norvegicus	129-139
15037818-6	2004	Furthermore, curcumin markedly inhibited LPS-induced nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1) DNA bindings.	Curcumin	13-21	jun proto-oncogene	Mus musculus	91-110
28561324-9	2018	In animals treated with the two higher curcumin concentrations, alone or in combination with adenine, an increased expression of the antioxidative transcription factor Nrf2 was found as well as up-regulation of the activity of its direct target glutathione reductase, and of an indirect target, the glutathione level.	Curcumin	39-47	glutathione-disulfide reductase	Rattus norvegicus	245-266
15037818-6	2004	Furthermore, curcumin markedly inhibited LPS-induced nuclear factor kappaB (NF-kappaB) and activator protein 1 (AP-1) DNA bindings.	Curcumin	13-21	jun proto-oncogene	Mus musculus	112-116
29560114-9	2018	Intriguingly, we observed that treatment with anti-tumoral epigenetic drugs like LBH-589 (Panobinostat) and Curcumin induced the expression of linc-PINT and HMOX1 in ALL.	Curcumin	108-116	long intergenic non-protein coding RNA, p53 induced transcript	Homo sapiens	143-152
14724571-8	2004	JNK activation and PARP cleavage induced by 30 nM Taxotere at 48 h were reversed by curcumin, PD169316 and SP600125, JNK inhibitors in order of progressive specificity.	Curcumin	84-92	collagen type XI alpha 2 chain	Homo sapiens	19-23
29560114-9	2018	Intriguingly, we observed that treatment with anti-tumoral epigenetic drugs like LBH-589 (Panobinostat) and Curcumin induced the expression of linc-PINT and HMOX1 in ALL.	Curcumin	108-116	heme oxygenase 1	Homo sapiens	157-162
29456509-8	2018	Also, SOCS1 and SOCS3, negative regulators of STAT3 activity, were upregulated by curcumin treatment.	Curcumin	82-90	suppressor of cytokine signaling 1	Homo sapiens	6-11
28914666-5	2018	The pleiotropic nonselective MCP-1/CCR2 inhibition by current pharmacological agents is thought to contribute to their anti-inflammatory and antiatherosclerotic effects that is also seen for nutraceutical compounds such as curcumin.	Curcumin	223-231	C-C motif chemokine ligand 2	Homo sapiens	29-34
14637190-2	2003	In this study, we observed that curcumin inhibited the kinase activity of v-Src, which led to a decrease in tyrosyl substrate phosphorylation of Shc, cortactin, and FAK.	Curcumin	32-40	protein tyrosine kinase 2	Homo sapiens	165-168
14597230-0	2003	Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction.	Curcumin	143-151	amyloid beta precursor like protein 2	Homo sapiens	51-56
30055545-13	2018	Therefore, we conclude that curcumin and resveratrol significantly modulated p53 post-translational modifications during gastric cancer.	Curcumin	28-36	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	77-80
12637253-8	2003	We conclude that the widely used food additive curcumin is able to attenuate experimental colitis through a mechanism correlated with the inhibition of the activation of NF-kappaB and effects a reduction in the activity of p38 MAPK.	Curcumin	47-55	mitogen-activated protein kinase 14	Mus musculus	223-231
30055551-8	2018	Moreover, curcumin treatment of the aluminum-treated animals also resulted in a significant improvement in the levels of GSH and enzyme activities of GST in both the cerebrum and cerebellum.	Curcumin	10-18	hematopoietic prostaglandin D synthase	Rattus norvegicus	150-153
27966075-12	2018	The results exhibit that curcumin modulates BDNF/DARPP32/CREB in arsenic-induced alterations in dopaminergic signaling in rat corpus striatum.	Curcumin	25-33	cAMP responsive element binding protein 1	Rattus norvegicus	57-61
29115530-0	2018	Curcumin suppresses Notch-1 signaling: Improvements in fatty liver and insulin resistance in rats.	Curcumin	0-8	notch receptor 1	Rattus norvegicus	20-27
12473670-12	2003	Most importantly, curcumin suppressed the OPN-induced tumor growth in nude mice, and the levels of pro-MMP-2 expression and activation in OPN-induced tumor were inhibited by curcumin.	Curcumin	174-182	secreted phosphoprotein 1	Mus musculus	138-141
29162665-18	2017	Curcumin also attenuated splanchnic hyperdynamic circulation by inducing vasoconstriction through inhibition of eNOS activation and by decreasing mesenteric angiogenesis via VEGF pathway blockade.	Curcumin	0-8	vascular endothelial growth factor A	Rattus norvegicus	174-178
12473670-13	2003	To our knowledge, this is the first report that OPN induces NF kappa B activity through phosphorylation and degradation of I kappa B alpha by activating IKK that ultimately triggers the activation of pro-MMP-2 and further demonstrates that curcumin potently suppresses OPN-induced cell migration, tumor growth, and NF kappa B-mediated pro-MMP-2 activation by blocking the IKK/I kappa B alpha signaling pathways.	Curcumin	240-248	secreted phosphoprotein 1	Mus musculus	48-51
12473670-13	2003	To our knowledge, this is the first report that OPN induces NF kappa B activity through phosphorylation and degradation of I kappa B alpha by activating IKK that ultimately triggers the activation of pro-MMP-2 and further demonstrates that curcumin potently suppresses OPN-induced cell migration, tumor growth, and NF kappa B-mediated pro-MMP-2 activation by blocking the IKK/I kappa B alpha signaling pathways.	Curcumin	240-248	secreted phosphoprotein 1	Mus musculus	269-272
12646172-1	2003	Our discovery of rapid down-regulation of human bilirubin UDP-glucuronosyltransferase (UGT) in colon cell lines that was transient and irreversible following curcumin- and calphostin-C-treatment, respectively, suggested phosphorylation event(s) were involved in activity.	Curcumin	158-166	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	58-85
28814374-6	2017	There are a variety of PAK1-blocking natural products such as propolis and curcumin which indeed extend the healthy lifespan of small animals such as C. elegans by inducing the autophagy.	Curcumin	75-83	Serine/threonine-protein kinase pak-1	Caenorhabditis elegans	23-27
28628927-0	2017	Curcumin Promotes Apoptosis of Activated Hepatic Stellate Cells by Inhibiting Protein Expression of the MyD88 Pathway.	Curcumin	0-8	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	104-109
28628927-5	2017	Here, we investigated whether curcumin accelerates apoptosis of HSC through the MyD88 pathway.	Curcumin	30-38	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	80-85
28628927-10	2017	Both curcumin and MyD88 siRNA inhibited the mRNA expression of MyD88 pathway-related effectors (TLR2, TLR4, NF-kappaB, TNF-alpha, IL-1beta) in HSC.	Curcumin	5-13	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	63-68
28628927-12	2017	These effects were more obvious in the curcumin + MyD88 siRNA group.	Curcumin	39-47	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	50-55
28628927-13	2017	This study demonstrates that curcumin promotes apoptosis of activated HSC by inhibiting the expression of cytokines related to the MyD88 pathway.	Curcumin	29-37	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	131-136
28628927-14	2017	It elucidates the possible mechanisms of curcumin in inducing apoptosis of HSC through the MyD88 pathway.	Curcumin	41-49	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	91-96
12646172-1	2003	Our discovery of rapid down-regulation of human bilirubin UDP-glucuronosyltransferase (UGT) in colon cell lines that was transient and irreversible following curcumin- and calphostin-C-treatment, respectively, suggested phosphorylation event(s) were involved in activity.	Curcumin	158-166	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	87-90
29291086-6	2017	In addition, curcumin stimulated lipolysis and improved glycolipid metabolism through upregulating the expressions of adipose triglyceride lipase and hormone-sensitive lipase, peroxisome proliferator activated receptor gamma/alpha (PPARgamma/alpha) and CCAAT/enhancer binding proteinalpha (C/EBPalpha) in adipose tissue of the mice.	Curcumin	13-21	patatin-like phospholipase domain containing 2	Mus musculus	118-145
12388178-12	2003	Curcumin blocked endotoxin-mediated activation of NF-kappaB and suppressed the expression of cytokines, chemokines, COX-2, and iNOS in Kupffer cells.	Curcumin	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	116-121
28951138-8	2017	Furthermore, curcumin significantly increased the mRNA and protein expression of PGC-1alpha and SIRT3 in the skeletal muscle tissues of COPD rats.	Curcumin	13-21	sirtuin 3	Rattus norvegicus	96-101
28951138-9	2017	These results suggested that curcumin can attenuate skeletal muscle mitochondrial impairment in COPD rats possibly by the up-regulation of PGC-1alpha/SIRT3 signaling pathway.	Curcumin	29-37	sirtuin 3	Rattus norvegicus	150-155
12558976-3	2003	Glutamate"s actions could also be prevented by known blockers of this pathway, MK-801 (an NMDA receptor blocker), SB 203580 (a p38 kinase inhibitor) and curcumin (an AP-1 binding inhibitor).	Curcumin	153-161	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	166-170
27667581-4	2017	The stability of the complexes of COX-1, COX-2, Topo I, Topo IIbeta and aromatase with the most potent inhibitor curcumin and those of the respective drugs, namely ibuprofen, aspirin, topotecan, etoposide, and exemestane were also analyzed through MD simulation analyses which revealed better stability of curcumin complexes than those of respective drugs.	Curcumin	306-314	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	34-39
29083232-0	2017	Co-Delivery of Curcumin and Chrysin by Polymeric Nanoparticles Inhibit Synergistically Growth and hTERT Gene Expression in Human Colorectal Cancer Cells.	Curcumin	15-23	telomerase reverse transcriptase	Homo sapiens	98-103
12488237-3	2003	We report here that curcumin, a natural phytochemical known to inhibit NF-kappaB and activator protein (AP)-1, another important proinflammatory transcription factor, ameliorates pancreatitis in two rat models.	Curcumin	20-28	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	85-109
28882690-0	2017	Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells.	Curcumin	85-93	immunoglobulin heavy diversity 1-7	Homo sapiens	103-107
28882690-4	2017	The curcumin analogue DM-1 (sodium 4-[5-(4-hydroxy-3-methoxy-phenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate) has substantial anti-tumor activity in melanoma, but its mechanism of action remains unclear.	Curcumin	4-12	immunoglobulin heavy diversity 1-7	Homo sapiens	22-26
12678405-8	2003	Curcumin enhances the expression of antimetastatic proteins, tissue inhibitor metalloproteinase (TIMP)-2, nonmetastatic gene 23 (Nm23), and E-cadherin.	Curcumin	0-8	tissue inhibitor of metalloproteinase 2	Mus musculus	61-104
12678405-9	2003	In this article we report on the effect of curcumin on the expression of integrin, TIMP-2, Nm23, E-cadherin, adhesion, and metalloproteinase activity.	Curcumin	43-51	tissue inhibitor of metalloproteinase 2	Mus musculus	83-89
12973926-0	2003	The effect of curcumin on mismatch repair (MMR) proteins hMSH2 and hMLH1 after ultraviolet (UV) irradiation on HL-60 cells.	Curcumin	14-22	mutS homolog 2	Homo sapiens	57-62
29062301-0	2017	Curcumin Exerts Effects on the Pathophysiology of Alzheimer"s Disease by Regulating PI(3,5)P2 and Transient Receptor Potential Mucolipin-1 Expression.	Curcumin	0-8	mucolipin 1	Mus musculus	98-138
12973926-5	2003	After irradiation and addition of curcumin, the expression of hMSH2 mRNA increased and the cellular apoptotic rate also increased at the same time.	Curcumin	34-42	mutS homolog 2	Homo sapiens	62-67
29062301-1	2017	BACKGROUND: To validate our speculation that curcumin may ameliorate Alzheimer"s disease (AD) pathogenesis by regulating PI(3,5)P2 and transient receptor potential mucolipin-1 (TRPML1) expression levels.	Curcumin	45-53	mucolipin 1	Mus musculus	135-175
29062301-1	2017	BACKGROUND: To validate our speculation that curcumin may ameliorate Alzheimer"s disease (AD) pathogenesis by regulating PI(3,5)P2 and transient receptor potential mucolipin-1 (TRPML1) expression levels.	Curcumin	45-53	mucolipin 1	Mus musculus	177-183
12710595-5	2003	Dietary supplementation of curcumin (2%, w/v) to male ddY mice for 30 days significantly increased the activities of glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase and catalase to 189%, 179%, 189%, and 181% in liver and 143%, 134%, 167% and 115% in kidney respectively as compared with corresponding normal diet fed control (P&lt;0.05-0.001).	Curcumin	27-35	glutathione reductase	Mus musculus	141-162
29062301-13	2017	Western blotting results also showed that TRPML1 was upregulated and mTOR/S6K signaling pathway was activated and markers of the autophagy-lysosomal system were downregulated after curcumin use in Abeta1-42-treated HT-22 cells.	Curcumin	181-189	mucolipin 1	Mus musculus	42-48
29062301-13	2017	Western blotting results also showed that TRPML1 was upregulated and mTOR/S6K signaling pathway was activated and markers of the autophagy-lysosomal system were downregulated after curcumin use in Abeta1-42-treated HT-22 cells.	Curcumin	181-189	mechanistic target of rapamycin kinase	Mus musculus	69-73
29062301-14	2017	Knockdown of PI (3,5)P2 or TRPML1 increased the protein levels of markers of the autophagy-lysosomal system after curcumin use in Abeta1-42-treated HT-22 cells, inhibited mTOR/S6K signaling pathway, increased the protein levels of markers of the autophagy-lysosomal system after curcumin use in APP/PS1 mice.	Curcumin	114-122	mucolipin 1	Mus musculus	27-33
29062301-14	2017	Knockdown of PI (3,5)P2 or TRPML1 increased the protein levels of markers of the autophagy-lysosomal system after curcumin use in Abeta1-42-treated HT-22 cells, inhibited mTOR/S6K signaling pathway, increased the protein levels of markers of the autophagy-lysosomal system after curcumin use in APP/PS1 mice.	Curcumin	279-287	mucolipin 1	Mus musculus	27-33
29062301-15	2017	Besides, knockdown of PI(3,5)P2 or TRPML1 reversed the protective role of curcumin on memory and recognition impairments in mice with APP/PS1 transgenes.	Curcumin	74-82	mucolipin 1	Mus musculus	35-41
29062301-15	2017	Besides, knockdown of PI(3,5)P2 or TRPML1 reversed the protective role of curcumin on memory and recognition impairments in mice with APP/PS1 transgenes.	Curcumin	74-82	presenilin 1	Mus musculus	138-141
29062301-16	2017	CONCLUSION: To some extent, it suggested that the effects of curcumin on AD pathogenesis were, at least partially, associated with PI(3,5)P2 and TRPML1 expression levels.	Curcumin	61-69	mucolipin 1	Mus musculus	145-151
12558151-6	2003	Diferuloylmethane blocks the induced expression of ICAM-1 and VCAM-1 in liver and lungs.	Curcumin	0-17	intercellular adhesion molecule 1	Mus musculus	51-57
28684236-9	2017	Curcumin protected adipocytes from hypoxia induced inflammation and insulin resistance via reducing inflammatory adipokine, nuclear factor-kappaB (NF-kappaB)/c-jun N-terminal kinase (JNK) and serine phosphorylation of IRS-1 receptors and improving adiponectin secretion.	Curcumin	0-8	insulin receptor substrate 1	Homo sapiens	218-223
28504250-0	2017	Curcumin enhances vascular contractility via induction of myocardin in mouse smooth muscle cells.	Curcumin	0-8	myocardin	Mus musculus	58-67
28504250-4	2017	Furthermore, the contractility of vascular smooth muscle (SM) was significantly enhanced after incubation in curcumin (25 mumol/L) for 4 days, which was accompanied by upregulated expression of SM marker contractile proteins SM22alpha and SM alpha-actin.	Curcumin	109-117	transgelin	Mus musculus	225-234
28504250-5	2017	In cultured vascular smooth muscle cells (VSMCs), curcumin (10, 25, 50 mumol/L) significantly increased the expression of myocardin, a "master regulator" of SM gene expression.	Curcumin	50-58	myocardin	Mus musculus	122-131
28504250-6	2017	Curcumin treatment also significantly increased the levels of caveolin-1 in VSMCs.	Curcumin	0-8	caveolin 1, caveolae protein	Mus musculus	62-72
28504250-7	2017	We found that as a result of the upregulation of caveolin-1, curcumin blocked the activation of notch1 and thereby abolished Notch1-inhibited myocardin expression.	Curcumin	61-69	caveolin 1, caveolae protein	Mus musculus	49-59
28504250-7	2017	We found that as a result of the upregulation of caveolin-1, curcumin blocked the activation of notch1 and thereby abolished Notch1-inhibited myocardin expression.	Curcumin	61-69	notch 1	Mus musculus	96-102
28504250-7	2017	We found that as a result of the upregulation of caveolin-1, curcumin blocked the activation of notch1 and thereby abolished Notch1-inhibited myocardin expression.	Curcumin	61-69	notch 1	Mus musculus	125-131
28504250-7	2017	We found that as a result of the upregulation of caveolin-1, curcumin blocked the activation of notch1 and thereby abolished Notch1-inhibited myocardin expression.	Curcumin	61-69	myocardin	Mus musculus	142-151
28504250-8	2017	Knockdown of caveolin-1 or activation of Notch1 signaling with Jagged1 (2 mug/mL) diminished these effects of curcumin in VSMCs.	Curcumin	110-118	caveolin 1, caveolae protein	Mus musculus	13-23
28504250-8	2017	Knockdown of caveolin-1 or activation of Notch1 signaling with Jagged1 (2 mug/mL) diminished these effects of curcumin in VSMCs.	Curcumin	110-118	notch 1	Mus musculus	41-47
28504250-9	2017	These findings suggest that curcumin induces the expression of myocardin in mouse smooth muscle cells via a variety of mechanisms, including caveolin-1-mediated inhibition of notch1 activation and Notch1-mediated repression of myocardin expression.	Curcumin	28-36	myocardin	Mus musculus	63-72
28504250-9	2017	These findings suggest that curcumin induces the expression of myocardin in mouse smooth muscle cells via a variety of mechanisms, including caveolin-1-mediated inhibition of notch1 activation and Notch1-mediated repression of myocardin expression.	Curcumin	28-36	caveolin 1, caveolae protein	Mus musculus	141-151
28504250-9	2017	These findings suggest that curcumin induces the expression of myocardin in mouse smooth muscle cells via a variety of mechanisms, including caveolin-1-mediated inhibition of notch1 activation and Notch1-mediated repression of myocardin expression.	Curcumin	28-36	notch 1	Mus musculus	175-181
28504250-9	2017	These findings suggest that curcumin induces the expression of myocardin in mouse smooth muscle cells via a variety of mechanisms, including caveolin-1-mediated inhibition of notch1 activation and Notch1-mediated repression of myocardin expression.	Curcumin	28-36	notch 1	Mus musculus	197-203
28504250-9	2017	These findings suggest that curcumin induces the expression of myocardin in mouse smooth muscle cells via a variety of mechanisms, including caveolin-1-mediated inhibition of notch1 activation and Notch1-mediated repression of myocardin expression.	Curcumin	28-36	myocardin	Mus musculus	227-236
28962965-0	2017	Effects of nanoparticle-encapsulated curcumin on HIV-gp120-associated neuropathic pain induced by the P2X3 receptor in dorsal root ganglia.	Curcumin	37-45	purinergic receptor P2X 3	Rattus norvegicus	102-106
28962965-5	2017	In this study, we sought to explore the effects of nanoparticle-encapsulated curcumin (nano curcumin) on HIV-gp120-induced neuropathic pain mediated by the P2X3 receptor in DRG neurons.	Curcumin	77-85	purinergic receptor P2X 3	Rattus norvegicus	156-160
28962965-5	2017	In this study, we sought to explore the effects of nanoparticle-encapsulated curcumin (nano curcumin) on HIV-gp120-induced neuropathic pain mediated by the P2X3 receptor in DRG neurons.	Curcumin	92-100	purinergic receptor P2X 3	Rattus norvegicus	156-160
28962965-8	2017	Nano curcumin treatment decreased mechanical hyperalgesia and thermal hyperalgesia and upregulated the expression levels of P2X3 mRNA and protein in rats treated with gp120.	Curcumin	5-13	purinergic receptor P2X 3	Rattus norvegicus	124-128
28962965-10	2017	In addition, P2X3 agonist alpha,beta-methylene ATP (alpha,beta-meATP)-induced currents in DRG neurons cultured with gp120 significantly decreased after co-treatment with nano curcumin.	Curcumin	175-183	purinergic receptor P2X 3	Rattus norvegicus	13-17
28962965-11	2017	Therefore, nano curcumin treatment may inhibit P2X3 activation, decrease the sensitizing DRG primary afferents and relieve mechanical hyperalgesia and thermal hyperalgesia in gp120-treated rats.	Curcumin	16-24	purinergic receptor P2X 3	Rattus norvegicus	47-51
29048549-0	2017	Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression.	Curcumin	0-8	Pvt1 oncogene	Homo sapiens	108-112
29048549-8	2017	Here, we report the re-sensitization of chemoresistant PDAC cells by curcumin through the inhibition of the PRC2-PVT1-c-Myc axis.	Curcumin	69-77	Pvt1 oncogene	Homo sapiens	113-117
29048549-8	2017	Here, we report the re-sensitization of chemoresistant PDAC cells by curcumin through the inhibition of the PRC2-PVT1-c-Myc axis.	Curcumin	69-77	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	118-123
29048549-9	2017	Using gemcitabine-resistant PDAC cell lines, we found that curcumin sensitized chemoresistant cancer cells by inhibiting the expression of the PRC2 subunit EZH2 and its related lncRNA PVT1.	Curcumin	59-67	Pvt1 oncogene	Homo sapiens	184-188
29028430-0	2017	Curcumin Prevents Osteoarthritis by Inhibiting the Activation of Inflammasome NLRP3.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	78-83
29028430-14	2017	This study provides the first evidence that curcumin exerts protection on osteoarthritis by inhibition to the release of inflammasome NLRP3, leading to the downregulation of inflammatory cytokines.	Curcumin	44-52	NLR family, pyrin domain containing 3	Mus musculus	134-139
28791384-0	2017	Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation.	Curcumin	0-8	vascular endothelial growth factor A	Rattus norvegicus	78-82
28791384-9	2017	In addition, curcumin decreased neovascularization and the expression of VEGF.	Curcumin	13-21	vascular endothelial growth factor A	Rattus norvegicus	73-77
28791384-11	2017	Furthermore, curcumin treatment decreased the expression of vascular cell adhesion molecule-1, intracellular adhesion molecule-1, monocyte chemoattractant protein-1 and tumor necrosis factor-alpha.	Curcumin	13-21	C-C motif chemokine ligand 2	Rattus norvegicus	130-196
28791384-13	2017	Treatment with curcumin inhibited TAA development in rats, which was associated with suppression of VEGF expression.	Curcumin	15-23	vascular endothelial growth factor A	Rattus norvegicus	100-104
28608236-0	2017	The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB-BDNF Signaling Pathway.	Curcumin	30-38	cAMP responsive element binding protein 1	Rattus norvegicus	93-97
28608236-3	2017	The current study was designed to evaluate the role of CREB-BDNF signaling in mediating the neuroprotective effects of curcumin against nicotine-induced apoptosis, oxidative stress and inflammation in rats.	Curcumin	119-127	cAMP responsive element binding protein 1	Rattus norvegicus	55-59
28806703-0	2017	NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin.	Curcumin	153-161	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	92-97
28806703-6	2017	Among apoptosis-related proteins, thioridazine plus curcumin induced down-regulation of c-FLIP and Mcl-1 expression at the post-translational levels in a proteasome-dependent manner.	Curcumin	52-60	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	99-104
28806703-9	2017	Furthermore, ectopic expression of c-FLIP and Mcl-1 inhibited apoptosis in thioridazine and curcumin-treated cells.	Curcumin	92-100	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	46-51
28754619-0	2017	Celecoxib-induced inhibition of neurogenesis in fetal frontal cortex is attenuated by curcumin via Wnt/beta-catenin pathway.	Curcumin	86-94	catenin beta 1	Homo sapiens	103-115
28754619-6	2017	Treatment with curcumin significantly could attenuate the celecoxib-induced deficits in proliferation through activating the Wnt/beta-Catenin pathway.	Curcumin	15-23	catenin beta 1	Homo sapiens	129-141
28675599-1	2017	To develop a multifunctional nanomaterial for dual-mode imaging and synergetic chemotherapy, curcumin (CUR) was physically entrapped into hollow upconversion NaGdF4 nanomaterial, then apoferritin (AFn) loaded with doxorubicin (DOX) was attached to the NaGdF4 surface.	Curcumin	93-101	ferritin heavy chain 1	Homo sapiens	184-195
28675599-1	2017	To develop a multifunctional nanomaterial for dual-mode imaging and synergetic chemotherapy, curcumin (CUR) was physically entrapped into hollow upconversion NaGdF4 nanomaterial, then apoferritin (AFn) loaded with doxorubicin (DOX) was attached to the NaGdF4 surface.	Curcumin	93-101	ferritin heavy chain 1	Homo sapiens	197-200
28199114-7	2017	administration of curcumin/mPEG-PCL-Phe(Boc) micelles could retain curcumin in plasma much better than curcumin/mPEG-PCL micelles.	Curcumin	67-75	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	Mus musculus	27-44
28199114-7	2017	administration of curcumin/mPEG-PCL-Phe(Boc) micelles could retain curcumin in plasma much better than curcumin/mPEG-PCL micelles.	Curcumin	67-75	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	Mus musculus	27-44
28199114-10	2017	administration of curcumin-loaded mPEG-PCL-Phe(Boc) micelles significantly delayed tumor growth, which was attributed to the improved stability of curcumin in the bloodstream and increased systemic bioavailability.	Curcumin	18-26	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	Mus musculus	34-51
28199114-10	2017	administration of curcumin-loaded mPEG-PCL-Phe(Boc) micelles significantly delayed tumor growth, which was attributed to the improved stability of curcumin in the bloodstream and increased systemic bioavailability.	Curcumin	147-155	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	Mus musculus	34-51
28199114-11	2017	The mPEG-PCL-Phe(Boc) micellar system is promising in overcoming the key challenge of curcumin"s to promote its applications in cancer therapy.	Curcumin	86-94	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	Mus musculus	4-21
29245915-4	2017	Sildenafil and curcumin reduced mTORC1 and mTORC2 activity and increased Beclin1 levels and the numbers of autophagosomes and autolysosomes in cells in a PERK-eIF2alpha-dependent fashion.	Curcumin	15-23	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	154-158
29245915-7	2017	Curcumin and sildenafil exposure reduced the expression of MCL-1, BCL-XL, thioredoxin and superoxide dismutase 2 (SOD2) in an eIF2alpha-dependent fashion.	Curcumin	0-8	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	59-64
29245915-7	2017	Curcumin and sildenafil exposure reduced the expression of MCL-1, BCL-XL, thioredoxin and superoxide dismutase 2 (SOD2) in an eIF2alpha-dependent fashion.	Curcumin	0-8	thioredoxin	Homo sapiens	74-85
29245915-8	2017	Curcumin and sildenafil interacted in a greater than additive fashion to increase the levels of reactive oxygen species; knock down of thioredoxin or SOD2 enhanced killing and over-expression of thioredoxin or SOD2 suppressed killing.	Curcumin	0-8	thioredoxin	Homo sapiens	195-206
29509269-0	2018	Curcumin attenuates IR-induced myocardial injury by activating SIRT3.	Curcumin	0-8	sirtuin 3	Rattus norvegicus	63-68
29197967-12	2018	Curcumin induced a strong and significant reduction of all miR analyzed, except for has-miR-204, in both cell lines.	Curcumin	0-8	microRNA 204	Homo sapiens	88-95
29034440-10	2018	Curcumin decreased risperidone-induced increases in serum markers of hepatotoxicity (ALAT, ASAT), as well as of one major hepatic pro-inflammatory transcription factor (NFkappaB: p105 mRNA and p65 protein).	Curcumin	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	193-196
29340361-0	2018	A curcumin-loaded polymeric micelle as a carrier of a microRNA-21 antisense-oligonucleotide for enhanced anti-tumor effects in a glioblastoma animal model.	Curcumin	2-10	microRNA 21	Homo sapiens	54-65
29340361-4	2018	The curcumin-loaded DP micelle (DP-Cur) was evaluated as a carrier for the combined delivery of curcumin and miR21ASO.	Curcumin	4-12	microRNA 21	Homo sapiens	109-117
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	vascular cell adhesion molecule 1	Mus musculus	100-133
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	vascular cell adhesion molecule 1	Mus musculus	135-141
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	vascular cell adhesion molecule 1	Mus musculus	286-292
29541412-0	2018	Curcumin increases breast cancer cell sensitivity to cisplatin by decreasing FEN1 expression.	Curcumin	0-8	flap structure-specific endonuclease 1	Homo sapiens	77-81
29541412-4	2018	Curcumin down-regulated FEN1 expression in a dose-dependent manner.	Curcumin	0-8	flap structure-specific endonuclease 1	Homo sapiens	24-28
29541412-5	2018	A combination of cisplatin and curcumin enhanced breast cancer cell sensitivity to cisplatin by down-regulating FEN1 expression in vitro and in vivo.	Curcumin	31-39	flap structure-specific endonuclease 1	Homo sapiens	112-116
29541412-7	2018	Inhibiting ERK phosphorylation stimulated the chemosensitizing effect of curcumin to cisplatin by targeting FEN1.	Curcumin	73-81	flap structure-specific endonuclease 1	Homo sapiens	108-112
12483537-0	2002	Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation.	Curcumin	0-8	cyclin D1	Homo sapiens	86-95
12483537-0	2002	Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation.	Curcumin	0-8	cyclin dependent kinase 4	Homo sapiens	111-115
12483537-4	2002	It is possible that the effect of curcumin is mediated through the regulation of cyclin D1.	Curcumin	34-42	cyclin D1	Homo sapiens	81-90
12483537-5	2002	In the present report we show that inhibition of the proliferation of various prostate, breast and squamous cell carcinoma cell lines by curcumin correlated with the down-regulation of the expression of cyclin D1 protein.	Curcumin	137-145	cyclin D1	Homo sapiens	203-212
12483537-7	2002	The suppression of cyclin D1 by curcumin led to inhibition of CDK4-mediated phosphorylation of retinoblastoma protein.	Curcumin	32-40	cyclin D1	Homo sapiens	19-28
12483537-7	2002	The suppression of cyclin D1 by curcumin led to inhibition of CDK4-mediated phosphorylation of retinoblastoma protein.	Curcumin	32-40	cyclin dependent kinase 4	Homo sapiens	62-66
12483537-8	2002	We found that curcumin-induced down-regulation of cyclin D1 was inhibited by lactacystin, an inhibitor of 26S proteosome, suggesting that curcumin represses cyclin D1 expression by promoting proteolysis.	Curcumin	14-22	cyclin D1	Homo sapiens	50-59
12483537-8	2002	We found that curcumin-induced down-regulation of cyclin D1 was inhibited by lactacystin, an inhibitor of 26S proteosome, suggesting that curcumin represses cyclin D1 expression by promoting proteolysis.	Curcumin	14-22	cyclin D1	Homo sapiens	157-166
12483537-8	2002	We found that curcumin-induced down-regulation of cyclin D1 was inhibited by lactacystin, an inhibitor of 26S proteosome, suggesting that curcumin represses cyclin D1 expression by promoting proteolysis.	Curcumin	138-146	cyclin D1	Homo sapiens	50-59
12483537-8	2002	We found that curcumin-induced down-regulation of cyclin D1 was inhibited by lactacystin, an inhibitor of 26S proteosome, suggesting that curcumin represses cyclin D1 expression by promoting proteolysis.	Curcumin	138-146	cyclin D1	Homo sapiens	157-166
12483537-10	2002	Curcumin also inhibited the activity of the cyclin D1 promoter-dependent reporter gene expression.	Curcumin	0-8	cyclin D1	Homo sapiens	44-53
12483537-11	2002	Overall our results suggest that curcumin down-regulates cyclin D1 expression through activation of both transcriptional and post-transcriptional mechanisms, and this may contribute to the antiproliferative effects of curcumin against various cell types.	Curcumin	33-41	cyclin D1	Homo sapiens	57-66
12483537-11	2002	Overall our results suggest that curcumin down-regulates cyclin D1 expression through activation of both transcriptional and post-transcriptional mechanisms, and this may contribute to the antiproliferative effects of curcumin against various cell types.	Curcumin	218-226	cyclin D1	Homo sapiens	57-66
12359244-10	2002	Our results on Northern blot analysis clearly indicated a time-dependent (0-24h) inhibition by curcumin of VEGF, angiopoietin 1 and 2 gene expression in EAT cells, VEGF and angiopoietin 1 gene expression in NIH3T3 cells, and KDR gene expression in HUVECs.	Curcumin	95-103	kinase insert domain protein receptor	Mus musculus	225-228
12237165-8	2002	Mithramycin A (10(-6) mol/l) and curcumin (10(-6) mol/l), prevented the upregulation of nNOS and ERalpha in neutrophils derived from men, suggesting the involvement of AP-1 and Sp-1 transcription factors.	Curcumin	33-41	nitric oxide synthase 1	Homo sapiens	88-92
12190122-6	2002	The acute rabbit kidney (RK13) cell apoptosis (cell death in &lt; 5 h) induced by apical or basal application of MDP was associated with glutamate (Glu) release, decreased gamma-glutamyltranspeptidase (GGT) and acidosis and was suppressed by Indomethacin, Naproxen and Curcumin.	Curcumin	269-277	dipeptidase 1	Homo sapiens	113-116
12055272-7	2002	In vitro treatment of activated T cells with curcumin inhibited IL-12-induced tyrosine phosphorylation of Janus kinase 2, tyrosine kinase 2, and STAT3 and STAT4 transcription factors.	Curcumin	45-53	tyrosine kinase 2	Mus musculus	122-139
11751895-7	2002	Similarly, a selective mitogen-activated protein kinase (MAPK) kinase (MEK)1/2 inhibitor (PD98059) and c-jun/activator protein (AP)-1 inhibitor (curcumin) suppressed MMP-13 mRNA up-regulation induced by MIF.	Curcumin	145-153	jun proto-oncogene	Mus musculus	103-108
28891094-9	2017	In this review, we highlight natural compounds, such as curcumin, indol-3 carbinol, and omega-3 fatty acids, that have the potential to restore or potentiate PTEN expression/activity, thereby suppressing cancer cell proliferation, survival, and resistance to chemotherapeutic agents.	Curcumin	56-64	phosphatase and tensin homolog	Homo sapiens	158-162
28286973-0	2017	Curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway.	Curcumin	0-8	insulin like growth factor 2	Homo sapiens	62-66
28286973-0	2017	Curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway.	Curcumin	0-8	insulin like growth factor 2	Homo sapiens	71-75
11716543-6	2001	Both a caspase-8 and broad-based caspase inhibitor, but not a caspase-9 specific inhibitor, suppressed curcumin-induced cell death.	Curcumin	103-111	caspase 8	Homo sapiens	7-16
28286973-2	2017	In this study, we report that curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway.	Curcumin	30-38	insulin like growth factor 2	Homo sapiens	92-96
28286973-2	2017	In this study, we report that curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway.	Curcumin	30-38	insulin like growth factor 2	Homo sapiens	101-105
28286973-3	2017	Curcumin inhibits IGF2 expression at the transcriptional level and decreases the phosphorylation levels of IGF1R and IRS-1 in bladder cancer cells and N-methyl-N-nitrosourea (MNU)-induced urothelial tumor tissue.	Curcumin	0-8	insulin like growth factor 2	Homo sapiens	18-22
11322764-1	2001	We conducted the following experiments to determine whether curcumin, an antioxidant compound extracted from the spice tumeric, inhibits cell death induced by Shiga toxin (Stx) 1 and 2 in HK-2 cells, a human proximal tubule cell line.	Curcumin	60-68	hexokinase 2	Homo sapiens	188-192
28286973-3	2017	Curcumin inhibits IGF2 expression at the transcriptional level and decreases the phosphorylation levels of IGF1R and IRS-1 in bladder cancer cells and N-methyl-N-nitrosourea (MNU)-induced urothelial tumor tissue.	Curcumin	0-8	insulin receptor substrate 1	Homo sapiens	117-122
28286973-4	2017	Ectopic expression of IGF2 and IGF1R, but not IGF1, in bladder cancer cells restored this process, suggesting that IGF2 is a target of curcumin.	Curcumin	135-143	insulin like growth factor 2	Homo sapiens	22-26
28286973-4	2017	Ectopic expression of IGF2 and IGF1R, but not IGF1, in bladder cancer cells restored this process, suggesting that IGF2 is a target of curcumin.	Curcumin	135-143	insulin like growth factor 2	Homo sapiens	115-119
28286973-5	2017	Moreover, introduction of constitutively active AKT1 abolished the inhibitory effect of curcumin on cell proliferation, migration, and restored the phosphorylation levels of 4E-BP1 and S6K1, suggesting that curcumin functions via suppressing IGF2-mediated AKT/mTOR signaling pathway.	Curcumin	88-96	insulin like growth factor 2	Homo sapiens	242-246
11067935-8	2000	In contrast, LPS-mediated TLR2 mRNA induction was abrogated by pretreatment with a high concentration of curcumin, suggesting that NF-kappaB activation may be essential for the process.	Curcumin	105-113	toll-like receptor 2	Mus musculus	26-30
28286973-5	2017	Moreover, introduction of constitutively active AKT1 abolished the inhibitory effect of curcumin on cell proliferation, migration, and restored the phosphorylation levels of 4E-BP1 and S6K1, suggesting that curcumin functions via suppressing IGF2-mediated AKT/mTOR signaling pathway.	Curcumin	207-215	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	174-180
28627596-8	2017	Curcumin was demonstrated to inhibit the IL-1beta-induced activation of NF-kappaB by suppressing IkappaBalpha phosphorylation and p65/RelA nuclear translocation.	Curcumin	0-8	NFKB inhibitor alpha	Rattus norvegicus	97-109
28627596-8	2017	Curcumin was demonstrated to inhibit the IL-1beta-induced activation of NF-kappaB by suppressing IkappaBalpha phosphorylation and p65/RelA nuclear translocation.	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	134-138
28789415-0	2017	Curcumin induces apoptotic cell death in human pancreatic cancer cells via the miR-340/XIAP signaling pathway.	Curcumin	0-8	microRNA 340	Homo sapiens	79-86
28789415-3	2017	Results from the present study demonstrate that the miR-340/X-linked inhibitor of apoptosis (XIAP) signaling pathway mediates curcumin-induced pancreatic cancer cell apoptosis.	Curcumin	126-134	microRNA 340	Homo sapiens	52-59
28789415-4	2017	miR-340 was identified to be significantly upregulated following curcumin treatment.	Curcumin	65-73	microRNA 340	Homo sapiens	0-7
29541412-9	2018	We also demonstrated that curcumin sensitizes breast cancer cells to cisplatin through FEN1 down-regulation.	Curcumin	26-34	flap structure-specific endonuclease 1	Homo sapiens	87-91
11069500-8	2000	Decreased PhK activity in curcumin-and calcipotriol-treated psoriasis was associated with corresponding decreases in keratinocyte transferrin receptor (TRR) expression, severity of parakeratosis and density of epidermal CD8+ T cells.	Curcumin	26-34	transferrin receptor	Homo sapiens	130-150
29277765-13	2018	DNA repair-related genes CCNH and XRCC5 were upregulated and LIG4 and PNKP downregulated by the combination of curcumin and irradiation compared with irradiation alone (p&lt;0.05).	Curcumin	111-119	DNA ligase 4	Homo sapiens	61-65
29277765-16	2018	Downregulation of LIG4 and PNKP and upregulation of XRCC5 and CCNH DNA-repair-related genes were involved in the radio-sensitizing efficacy of curcumin in colon cancer.	Curcumin	143-151	DNA ligase 4	Homo sapiens	18-22
29866021-8	2018	Activation of NF-kappaB, expression of COX2, HIF-1alpha and cMyc, as well as expression and activity of LDH-A were significantly reduced by curcumin.	Curcumin	140-148	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	60-64
28789415-5	2017	In addition, treatment with curcumin or miR-340 induced pancreatic cancer cell apoptosis, whereas silencing endogenous miR-340 significantly inhibited the proapoptotic effect of curcumin.	Curcumin	178-186	microRNA 340	Homo sapiens	119-126
28789415-7	2017	Furthermore, curcumin treatment significantly reduced XIAP expression, an effect that was rescued by treatment with anti-miR-340.	Curcumin	13-21	microRNA 340	Homo sapiens	121-128
28789415-8	2017	The results of the present study suggest that the miR-340/XIAP signaling pathway is a downstream target of curcumin that mediates its proapoptotic effects on pancreatic cancer cells.	Curcumin	107-115	microRNA 340	Homo sapiens	50-57
28585748-0	2017	Effects of Curcumin on Tobacco Smoke-induced Hepatic MAPK Pathway Activation and Epithelial-Mesenchymal Transition In Vivo.	Curcumin	11-19	probable serine/threonine-protein kinase WNK4	Nicotiana tabacum	53-57
28585748-8	2017	Treatment of curcumin effectively attenuated tobacco smoke-induced activation of ERK1/2 and JNK MAPK pathways, AP-1 proteins and EMT alterations in the mice liver.	Curcumin	13-21	probable serine/threonine-protein kinase WNK4	Nicotiana tabacum	96-100
11069500-8	2000	Decreased PhK activity in curcumin-and calcipotriol-treated psoriasis was associated with corresponding decreases in keratinocyte transferrin receptor (TRR) expression, severity of parakeratosis and density of epidermal CD8+ T cells.	Curcumin	26-34	transferrin receptor	Homo sapiens	152-155
29040874-6	2018	Furthermore, curcumin has been loaded onto the cRGD-Exo, and administration of these exosomes has resulted in a strong suppression of the inflammatory response and cellular apoptosis in the lesion region.	Curcumin	13-21	5'-3' exoribonuclease 1	Mus musculus	52-55
11035063-4	2000	We demonstrated that NaAsO(2)-induced caspase activation is dependent on curcumin-sensitive c-Jun amino-terminal kinase and barely dependent on SB203580-sensitive p38 kinase or PD98059-sensitive extracellular signal-regulated kinase.	Curcumin	73-81	jun proto-oncogene	Mus musculus	92-97
30355954-9	2018	RESULTS: Curcumin had a promising inhibitory effect on osteolysis induced by wear debris and suppressed the RANK/c-Fos/NFATc1 signaling pathway.	Curcumin	9-17	FBJ osteosarcoma oncogene	Mus musculus	113-118
30355954-11	2018	An inhibitory effect on the RANK/c-Fos/NFATc1 signaling pathway may explain the anti-osteolysis activity of curcumin.	Curcumin	108-116	FBJ osteosarcoma oncogene	Mus musculus	33-38
30463061-0	2018	Curcumin Protects an SH-SY5Y Cell Model of Parkinson"s Disease Against Toxic Injury by Regulating HSP90.	Curcumin	0-8	heat shock protein 90 alpha family class A member 1	Homo sapiens	98-103
28585748-8	2017	Treatment of curcumin effectively attenuated tobacco smoke-induced activation of ERK1/2 and JNK MAPK pathways, AP-1 proteins and EMT alterations in the mice liver.	Curcumin	13-21	truncated transcription factor CAULIFLOWER A-like	Nicotiana tabacum	111-115
28585748-9	2017	Our data suggested the protective effect of curcumin in tobacco smoke-triggered MAPK pathway activation and EMT in the liver of BALB/c mice, thus providing new insights into the chemoprevention of tobacco smoke-associated hepatic cancer.	Curcumin	44-52	probable serine/threonine-protein kinase WNK4	Nicotiana tabacum	80-84
28785217-11	2017	Immunofluorescent staining further showed that curcumin treatment significantly increased the number of CD206+Iba1+ M2 microglia/macrophages and reduced the number of CD16+Iba1+ M1 cells 10 days after stroke.	Curcumin	47-55	induction of brown adipocytes 1	Mus musculus	110-114
28785217-11	2017	Immunofluorescent staining further showed that curcumin treatment significantly increased the number of CD206+Iba1+ M2 microglia/macrophages and reduced the number of CD16+Iba1+ M1 cells 10 days after stroke.	Curcumin	47-55	induction of brown adipocytes 1	Mus musculus	172-176
28509396-7	2017	Treatment with all concentrations of curcumin significantly improved total WBC, PLA2, TP, IgE, IL-4, IFN-gamma, IFN-gamma/IL-4 ratio, SOD, thiol, NO2 , and NO3 compared to S group (P &lt; 0.01 to P &lt; 0.001).	Curcumin	37-45	interferon gamma	Rattus norvegicus	101-110
28509396-7	2017	Treatment with all concentrations of curcumin significantly improved total WBC, PLA2, TP, IgE, IL-4, IFN-gamma, IFN-gamma/IL-4 ratio, SOD, thiol, NO2 , and NO3 compared to S group (P &lt; 0.01 to P &lt; 0.001).	Curcumin	37-45	interferon gamma	Rattus norvegicus	112-121
28618991-11	2018	In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1).	Curcumin	40-48	heme oxygenase 1	Homo sapiens	239-255
28618991-11	2018	In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1).	Curcumin	40-48	heme oxygenase 1	Homo sapiens	257-261
10988260-9	2000	This increase of c-fos mRNA expression was blocked by PD98059; in addition, curcumin, a blocker of the transcriptional factor AP-1, canceled the effect of Ang II on the collagen I gene.	Curcumin	76-84	jun proto-oncogene	Mus musculus	126-130
29189128-7	2018	In this context, up-regulation of miR181b, miR-34a, miR-16, miR-15a and miR-146b-5p, and down-regulation of miR-19a and miR-19b have been shown following the treatment of several breast cancer cell lines with curcumin.	Curcumin	209-217	microRNA 19b-1	Homo sapiens	120-127
29542427-9	2018	Meanwhile, all individual biomarkers showed no, less or moderate inhibitory effect towards all the tested CYP450 except for curcumin that showed inhibition of CYP2C8 (91%), CYP2C9 (81%) and CYP2C19 (72%) at 10microM.	Curcumin	124-132	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	173-179
10838160-7	2000	In addition, curcumin, an inhibitor for transcription factor AP-1, also blocked the induction.	Curcumin	13-21	jun proto-oncogene	Mus musculus	61-65
29542427-10	2018	CONCLUSION: Curcumin was found to be an active constituent that might contribute to the inhibition of SynacinnTM against CYP2C8, CYP2C9 and CYP2C19.	Curcumin	12-20	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	129-135
29578162-0	2018	The autophagy induced by curcumin via MEK/ERK pathway plays an early anti-leukemia role in human Philadelphia chromosome-positive acute lymphoblastic leukemia SUP-B15 cells.	Curcumin	25-33	EPH receptor B2	Homo sapiens	42-45
29578162-3	2018	We demonstrated that curcumin inhibited activation of Akt-mTOR, ABL/STAT5 pathways, inhibited cell proliferation, and induced apoptosis in Ph + ALL cells.	Curcumin	21-29	signal transducer and activator of transcription 5A	Homo sapiens	68-73
29578162-4	2018	Experiments here, were conducted to determine whether autophagy via MEK/ERK pathway involved in anti-leukemia effect of curcumin in Ph + ALL.	Curcumin	120-128	EPH receptor B2	Homo sapiens	72-75
29578162-9	2018	Results: Curcumin treatment up-regulated the activation of RAF/MEK/ERK at 4 h and 8 h after curcumin exposure in SUP-B15 cells, curcumin treatment induced autophagy at exactly 4 h and 8 h after curcumin exposure.	Curcumin	9-17	EPH receptor B2	Homo sapiens	67-70
29578162-9	2018	Results: Curcumin treatment up-regulated the activation of RAF/MEK/ERK at 4 h and 8 h after curcumin exposure in SUP-B15 cells, curcumin treatment induced autophagy at exactly 4 h and 8 h after curcumin exposure.	Curcumin	92-100	EPH receptor B2	Homo sapiens	67-70
29578162-9	2018	Results: Curcumin treatment up-regulated the activation of RAF/MEK/ERK at 4 h and 8 h after curcumin exposure in SUP-B15 cells, curcumin treatment induced autophagy at exactly 4 h and 8 h after curcumin exposure.	Curcumin	128-136	EPH receptor B2	Homo sapiens	67-70
29578162-9	2018	Results: Curcumin treatment up-regulated the activation of RAF/MEK/ERK at 4 h and 8 h after curcumin exposure in SUP-B15 cells, curcumin treatment induced autophagy at exactly 4 h and 8 h after curcumin exposure.	Curcumin	128-136	EPH receptor B2	Homo sapiens	67-70
29578162-11	2018	MEK specific inhibitor U0126 inhibited the occurrence of autophagy, and then blocked curcumin-induced cytotoxicity at 4 h and 8 h. Conclusions: Curcumin induce autophagic cell death in SUP-B15 cells via activating RAF/MEK/ERK pathway.	Curcumin	85-93	EPH receptor B2	Homo sapiens	222-225
29578162-11	2018	MEK specific inhibitor U0126 inhibited the occurrence of autophagy, and then blocked curcumin-induced cytotoxicity at 4 h and 8 h. Conclusions: Curcumin induce autophagic cell death in SUP-B15 cells via activating RAF/MEK/ERK pathway.	Curcumin	144-152	EPH receptor B2	Homo sapiens	222-225
30055545-2	2018	The present study evaluated the potential of curcumin and resveratrol on p53 post-translational modifications during gastric cancer.	Curcumin	45-53	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	73-76
27966075-0	2018	Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus Striatum.	Curcumin	21-29	cAMP responsive element binding protein 1	Rattus norvegicus	57-61
10889462-0	2000	Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress.	Curcumin	0-8	heme oxygenase 1	Bos taurus	62-78
29597206-15	2018	It was observed that curcumin attenuated the expression of VEGF in the retina of diabetic rats.	Curcumin	21-29	vascular endothelial growth factor A	Rattus norvegicus	59-63
29597206-16	2018	We also discovered that curcumin had an antiapoptotic effect by upregulating the expression of Bcl-2 and downregulating the expression of Bax in the retina of diabetic rats.	Curcumin	24-32	BCL2 associated X, apoptosis regulator	Rattus norvegicus	138-141
29597206-17	2018	CONCLUSIONS: Taken together, these results suggest that curcumin may have great therapeutic potential in the treatment of diabetic retinopathy which could be attributed to the hypoglycemic, antioxidant, VEGF-downregulating and neuroprotection properties of curcumin.	Curcumin	56-64	vascular endothelial growth factor A	Rattus norvegicus	203-207
29597206-17	2018	CONCLUSIONS: Taken together, these results suggest that curcumin may have great therapeutic potential in the treatment of diabetic retinopathy which could be attributed to the hypoglycemic, antioxidant, VEGF-downregulating and neuroprotection properties of curcumin.	Curcumin	257-265	vascular endothelial growth factor A	Rattus norvegicus	203-207
10889462-3	2000	In the present study we examined the effect of curcumin on endothelial heme oxygenase-1 (HO-1 or HSP32), an inducible stress protein that degrades heme to the vasoactive molecule carbon monoxide and the antioxidant biliverdin.	Curcumin	47-55	heme oxygenase 1	Bos taurus	71-87
10889462-3	2000	In the present study we examined the effect of curcumin on endothelial heme oxygenase-1 (HO-1 or HSP32), an inducible stress protein that degrades heme to the vasoactive molecule carbon monoxide and the antioxidant biliverdin.	Curcumin	47-55	heme oxygenase 1	Bos taurus	89-93
29283372-11	2017	Further mechanistic study demonstrated that curcumin-Cu(II) or -Zn(II) complexes systems inhibited cell apoptosis via downregulating the nuclear factor kappaB (NF-kappaB) pathway and upregulating Bcl-2/Bax pathway.	Curcumin	44-52	BCL2 associated X, apoptosis regulator	Rattus norvegicus	202-205
10889462-4	2000	Exposure of bovine aortic endothelial cells to curcumin (5-15 microM) resulted in both a concentration- and time-dependent increase in HO-1 mRNA, protein expression and heme oxygenase activity.	Curcumin	47-55	heme oxygenase 1	Bos taurus	135-139
10889462-7	2000	In contrast, exposure of cells to curcumin for a period of time insufficient to up-regulate HO-1 (1.5 h) did not prevent oxidant-mediated injury.	Curcumin	34-42	heme oxygenase 1	Bos taurus	92-96
10889462-8	2000	These data indicate that curcumin is a potent inducer of HO-1 in vascular endothelial cells and that increased heme oxygenase activity is an important component in curcumin-mediated cytoprotection against oxidative stress.	Curcumin	25-33	heme oxygenase 1	Bos taurus	57-61
29255221-8	2017	Western blot analysis revealed that curcumin up-regulated BRCA1, BRCA2 and ERCC1 expression in bone marrow.	Curcumin	36-44	breast cancer 2, early onset	Mus musculus	65-70
11201293-6	2000	Select inhibitors of COX and LOX are described, including nonsteroidal antiinflammatory drugs (NSAIDs), selective COX-2 inhibitors, curcumin, tea, silymarin and resveratrol, as well as a method useful for evaluating inhibitors of COX.	Curcumin	132-140	cytochrome c oxidase subunit 8A	Homo sapiens	21-24
29255221-8	2017	Western blot analysis revealed that curcumin up-regulated BRCA1, BRCA2 and ERCC1 expression in bone marrow.	Curcumin	36-44	excision repair cross-complementing rodent repair deficiency, complementation group 1	Mus musculus	75-80
29259894-0	2017	Suppression of corneal neovascularization by curcumin via inhibition of Wnt/beta-catenin pathway activation.	Curcumin	45-53	Wnt family member 2	Rattus norvegicus	72-75
29259894-0	2017	Suppression of corneal neovascularization by curcumin via inhibition of Wnt/beta-catenin pathway activation.	Curcumin	45-53	catenin beta 1	Rattus norvegicus	76-88
29259894-1	2017	AIM: To investigate whether curcumin suppressed corneal neovascularization (CNV) formation via inhibiting activation of Wnt/beta-catenin pathway.	Curcumin	28-36	Wnt family member 2	Rattus norvegicus	120-123
29259894-1	2017	AIM: To investigate whether curcumin suppressed corneal neovascularization (CNV) formation via inhibiting activation of Wnt/beta-catenin pathway.	Curcumin	28-36	catenin beta 1	Rattus norvegicus	124-136
29259894-9	2017	Curcumin inhibited LRP6 phosphorylation and nuclear accumulation of beta-catenin.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	68-80
29259894-11	2017	Meanwhile curcumin suppressed suture-induced CNV and inhibited LRP6 phosphorylation as well as beta-catenin accumulation in SD rats.	Curcumin	10-18	catenin beta 1	Rattus norvegicus	95-107
10965519-0	2000	Genistein and curcumin block TGF-beta 1-induced u-PA expression and migratory and invasive phenotype in mouse epidermal keratinocytes.	Curcumin	14-22	transforming growth factor, beta 1	Mus musculus	29-39
29259894-12	2017	CONCLUSION: Taken together, activation of Wnt/beta-catenin pathway could be involved in endothelial proliferation during suture-induced CNV formation and curcumin attenuated CNV formation via inhibition of Wnt/beta-catenin pathway activation.	Curcumin	154-162	Wnt family member 2	Rattus norvegicus	42-45
29259894-12	2017	CONCLUSION: Taken together, activation of Wnt/beta-catenin pathway could be involved in endothelial proliferation during suture-induced CNV formation and curcumin attenuated CNV formation via inhibition of Wnt/beta-catenin pathway activation.	Curcumin	154-162	Wnt family member 2	Rattus norvegicus	206-209
29259894-12	2017	CONCLUSION: Taken together, activation of Wnt/beta-catenin pathway could be involved in endothelial proliferation during suture-induced CNV formation and curcumin attenuated CNV formation via inhibition of Wnt/beta-catenin pathway activation.	Curcumin	154-162	catenin beta 1	Rattus norvegicus	210-222
10419543-6	1999	Injection of curcumin at a dose that selectively inhibits AP-1 activation without affecting NF-kappaB activity attenuates DNA laddering induced by DA.	Curcumin	13-21	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-62
29312505-4	2017	Our results showed that curcumin attenuated the high expression levels of fibroblast proteins (alpha-SMA &amp; Vimentin) in GC-MSCs.	Curcumin	24-32	vimentin	Homo sapiens	111-119
29312508-0	2017	Curcumin combined with glycyrrhetinic acid inhibits the development of hepatocellular carcinoma cells by down-regulating the PTEN/PI3K/AKT signalling pathway.	Curcumin	0-8	phosphatase and tensin homolog	Homo sapiens	125-129
29312508-10	2017	Moreover, by knocking down the expression of PTEN, we confirmed that curcumin and GA exert their anticancer effects by inhibiting the PTEN/PI3K/Akt signalling pathway.	Curcumin	69-77	phosphatase and tensin homolog	Homo sapiens	45-49
29312508-10	2017	Moreover, by knocking down the expression of PTEN, we confirmed that curcumin and GA exert their anticancer effects by inhibiting the PTEN/PI3K/Akt signalling pathway.	Curcumin	69-77	phosphatase and tensin homolog	Homo sapiens	134-138
29312508-11	2017	Collectively, these results indicate that the combination of curcumin and GA could effectively inhibit the development of HepG2 cells by inhibiting PTEN/PI3K/Akt signalling and could be a promising treatment strategy for patients with HCC.	Curcumin	61-69	phosphatase and tensin homolog	Homo sapiens	148-152
28224816-8	2017	The enhanced phosphorylation of STAT3 was further strengthened by curcumin (10, 20 or 30 mg/kg/d) in a dose-dependent manner.	Curcumin	66-74	signal transducer and activator of transcription 3	Rattus norvegicus	32-37
28224816-9	2017	DISCUSSION AND CONCLUSION: Curcumin intake might reduce the risk of coronary heart disease by stimulating JAK2/STAT3 signal pathway, decreasing oxidative damage and inhibiting myocardium apoptosis.	Curcumin	27-35	signal transducer and activator of transcription 3	Rattus norvegicus	111-116
29225578-0	2017	Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/beta-Catenin Pathways via miR-130a.	Curcumin	0-8	catenin beta 1	Homo sapiens	69-81
9810264-5	1998	Results of this investigation indicate that compounds which inhibit C6 glial cell MAO enzyme activity or scavenge peroxide product include chlorogenic acid, (+)-catechin, taxifolin, (-)-epigallocatechin gallate (EGCG), fisetin, coenzyme Q0, curcumin, sesamol, morin, sesame oil, silymarin, green tea, ferulic acid, caffeic acid, and rutin hydrate.	Curcumin	241-249	monoamine oxidase A	Rattus norvegicus	82-85
29225578-8	2017	Further study suggested that curcumin inhibited cell proliferation by suppressing the Wnt/beta-catenin pathway.	Curcumin	29-37	catenin beta 1	Homo sapiens	90-102
29225578-10	2017	Our study confirms that curcumin is able to inhibit colon cancer by suppressing the Wnt/beta-catenin pathways via miR-130a.	Curcumin	24-32	catenin beta 1	Homo sapiens	88-100
29308351-0	2017	Molecular docking analysis of curcumin analogues against kinase domain of ALK5.	Curcumin	30-38	transforming growth factor beta receptor 1	Homo sapiens	74-78
9764755-1	1998	Curcumin, a major component of turmeric, a seasoning commonly used in Indian food, and a known antioxidant, anti-inflammatory and anti-carcinogenic agent, is a potent stimulator of the stress-induced expression of Hsp27, alphaB crystallin and Hsp70.	Curcumin	0-8	heat shock protein family B (small) member 1	Rattus norvegicus	214-219
29308351-3	2017	In the present study, efficacy of curcumin and its analogues as inhibitors of ALK5 (TGFbetaR-I) receptor was evaluated using in silico approaches.	Curcumin	34-42	transforming growth factor beta receptor 1	Homo sapiens	78-82
29308351-6	2017	The interaction of 142 curcumin analogues and curcumin with ALK5 receptor was studied using Autodock Vina.	Curcumin	23-31	transforming growth factor beta receptor 1	Homo sapiens	60-64
29308351-6	2017	The interaction of 142 curcumin analogues and curcumin with ALK5 receptor was studied using Autodock Vina.	Curcumin	46-54	transforming growth factor beta receptor 1	Homo sapiens	60-64
29308351-7	2017	This study revealed six curcumin analogues as promising ALK5 inhibitors with significant binding energy and H-bonding interaction.	Curcumin	24-32	transforming growth factor beta receptor 1	Homo sapiens	56-60
9764755-1	1998	Curcumin, a major component of turmeric, a seasoning commonly used in Indian food, and a known antioxidant, anti-inflammatory and anti-carcinogenic agent, is a potent stimulator of the stress-induced expression of Hsp27, alphaB crystallin and Hsp70.	Curcumin	0-8	crystallin, alpha B	Rattus norvegicus	221-238
9674701-6	1998	In transfection assays, curcumin moderately suppressed MEKK1-induced JNK activation; however, it effectively blocked JNK activation caused by co-transfection of TAK1, GCK, or HPK1.	Curcumin	24-32	mitogen-activated protein kinase kinase kinase 1	Homo sapiens	55-60
9733605-0	1998	Curcumin blocks cyclosporine A-resistant CD28 costimulatory pathway of human T-cell proliferation.	Curcumin	0-8	CD28 molecule	Homo sapiens	41-45
28870814-0	2017	Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.	Curcumin	0-8	sonic hedgehog signaling molecule	Homo sapiens	59-73
28870814-14	2017	Altogether, these data suggested that curcumin inhibited the activities of BCSCs through suppressing Shh pathway, which might be an effective chemopreventive agent for bladder cancer intervention.	Curcumin	38-46	sonic hedgehog signaling molecule	Homo sapiens	101-104
28951138-0	2017	Curcumin attenuates skeletal muscle mitochondrial impairment in COPD rats: PGC-1alpha/SIRT3 pathway involved.	Curcumin	0-8	sirtuin 3	Rattus norvegicus	86-91
8486642-8	1993	Furthermore, curcumin, a specific inhibitor of c-jun/AP-1, markedly inhibited JE gene expression and monocyte chemotactic activity induced by the cytokine.	Curcumin	13-21	jun proto-oncogene	Mus musculus	47-52
27667581-4	2017	The stability of the complexes of COX-1, COX-2, Topo I, Topo IIbeta and aromatase with the most potent inhibitor curcumin and those of the respective drugs, namely ibuprofen, aspirin, topotecan, etoposide, and exemestane were also analyzed through MD simulation analyses which revealed better stability of curcumin complexes than those of respective drugs.	Curcumin	113-121	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	34-39
29078859-0	2017	Corrigendum to "Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down-regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells" [J Nutr Biochem 44 (2017) 60-70].	Curcumin	16-24	slit guidance ligand 2	Homo sapiens	90-96
28901458-6	2017	In addition, treatment with curcumin reduced the mRNA expression levels of TGF-beta1 and TGF-beta2, whereas it increased the mRNA expression levels of BDNF in rats with LIDD.	Curcumin	28-36	transforming growth factor, beta 2	Rattus norvegicus	89-98
28509396-8	2017	Two higher concentrations of curcumin significantly decreased neutrophil and eosinophil counts and MDA level but increased IFN-gamma, CAT and lymphocyte values compared to S group (P &lt; 0.001 for all cases).	Curcumin	29-37	interferon gamma	Rattus norvegicus	123-132
28684765-8	2017	The curcumin pre-treatment abolished the expression of c-Fos and c-Jun but upregulated Fra-1 expression in UV-irradiated CaCxSLCs.	Curcumin	4-12	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	87-92
28684765-9	2017	Thus, the study suggests a critical role of AP-1 protein in the manifestation of radioresistance but targeting with curcumin helps in radiosensitizing CaCxSLCs through upregulation of Fra-1.	Curcumin	116-124	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	184-189
28258441-0	2017	TNF-alpha, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats.	Curcumin	78-86	interleukin 10	Rattus norvegicus	20-25
28258441-11	2017	Pre-treatment of curcumin reduced cisplatin-induced nephrotoxicity which was clearly evident from the reduced BUN, creatinine, TNF-alpha, IL-6 and IL-8 levels and increased albumin and IL-10 levels.	Curcumin	17-25	interleukin 10	Rattus norvegicus	185-190
28886247-3	2017	In this study, we developed a biomimetic nanodrug consisting of a self-assembling variant (HFn) of human apoferritin loaded with curcumin.	Curcumin	129-137	ferritin heavy chain 1	Homo sapiens	105-116
28258441-13	2017	In contrast, post-treatment of curcumin failed to cut down the expression of inflammatory markers substantially and also neglected to increase the expression of IL-10.	Curcumin	31-39	interleukin 10	Rattus norvegicus	161-166
33234350-0	2021	Curcumin represses mTORC1 signaling in Caco-2 cells by a two-sided mechanism involving the loss of IRS-1 and activation of AMPK.	Curcumin	0-8	CREB regulated transcription coactivator 1	Mus musculus	19-25
28258441-14	2017	The disparity in the action of curcumin after pre- and post-treatment with cisplatin-induced nephrotoxicity was due to the inability of post-treatment to reduce TNF-alpha &amp; IL-6, besides to show a concurrent rise in IL-10 expression in renal tissues.	Curcumin	31-39	interleukin 10	Rattus norvegicus	220-225
28605812-4	2017	In addition, the effect of curcumin on the TGFbeta1-induced NADPH oxidase expression and collagen synthesis was also investigated.	Curcumin	27-35	NADPH oxidase 1	Oryctolagus cuniculus	60-73
28402926-0	2017	Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down-regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells.	Curcumin	0-8	slit guidance ligand 2	Homo sapiens	74-80
28370178-3	2017	In vitro, it has been shown that curcumin can decrease hepcidin synthesis by decreasing STAT3 activity.	Curcumin	33-41	hepcidin antimicrobial peptide	Homo sapiens	55-63
28849163-0	2017	Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKbeta/NF-kappaB/COX-2 signaling pathway.	Curcumin	46-54	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	69-76
28848967-14	2017	The expression of DEC1, HIF-1alpha, STAT3 and VEGF in tumor tissues was down-regulated after curcumin treatment.	Curcumin	93-101	hypoxia inducible factor 1, alpha subunit	Mus musculus	24-34
28848967-15	2017	Our results indicate that curcumin inhibits the proliferation of gastric carcinoma by inducing the apoptosis of tumor cells, activating immune cells to secrete a large amount of cytokines, and down-regulating the DEC1, HIF-1alpha, VEGF and STAT3 signal transduction pathways.	Curcumin	26-34	hypoxia inducible factor 1, alpha subunit	Mus musculus	219-229
33234350-0	2021	Curcumin represses mTORC1 signaling in Caco-2 cells by a two-sided mechanism involving the loss of IRS-1 and activation of AMPK.	Curcumin	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	123-127
28887914-0	2017	Curcumin attenuates the scurfy-induced immune disorder, a model of IPEX syndrome, with inhibiting Th1/Th2/Th17 responses in mice.	Curcumin	0-8	heart and neural crest derivatives expressed 2	Mus musculus	102-105
28887914-9	2017	A curcumin diet decreased all of the Th1/Th2/Th17 cell populations and attenuated diverse symptoms such as splenomegaly in scurfy mice.	Curcumin	2-10	heart and neural crest derivatives expressed 2	Mus musculus	41-44
33234350-3	2021	Curcumin (CUR), a polyphenol found in turmeric roots (Curcuma longa) can repress mTORC1 kinase activity in colon cancer cell lines; however, key aspects of CUR mechanism of action remain to be elucidated including its primary cellular target.	Curcumin	0-8	CREB regulated transcription coactivator 1	Mus musculus	81-87
28887914-10	2017	In vitro experiments showed that curcumin treatment directly decreased the Th1/Th2/Th17 cytokine production of IFN-gamma, IL-4, and IL-17A in CD4+ T cells.	Curcumin	33-41	heart and neural crest derivatives expressed 2	Mus musculus	79-82
28887914-10	2017	In vitro experiments showed that curcumin treatment directly decreased the Th1/Th2/Th17 cytokine production of IFN-gamma, IL-4, and IL-17A in CD4+ T cells.	Curcumin	33-41	interleukin 4	Mus musculus	122-126
28402926-6	2017	In transwell migration studies, knock down of Slit-2 reversed the anti-migratory effect of curcumin in these cell lines.	Curcumin	91-99	slit guidance ligand 2	Homo sapiens	46-52
28402926-7	2017	Curcumin significantly up-regulated the expression of Slit-2 in Ishikawa, Hec-1B and primary endometrial cancer cells while it down-regulated the expression of stromal cell-derived factor-1 (SDF-1) and CXCR4 which in turn, suppressed the expression of matrix metallopeptidases (MMP) 2 and 9, thus attenuating the migration of endometrial cancer cells.	Curcumin	0-8	slit guidance ligand 2	Homo sapiens	54-60
28402926-8	2017	In summary, we have demonstrated that curcumin has inhibitory effect on cellular migration via Slit-2 mediated down-regulation of CXCR4, SDF-1, and MMP2/MMP9 in endometrial carcinoma cells.	Curcumin	38-46	slit guidance ligand 2	Homo sapiens	95-101
28887914-11	2017	CONCLUSIONS: Curcumin diet attenuated the scurfy-induced immune disorder, a model of IPEX syndrome, by inhibiting Th1/Th2/Th17 responses in mice.	Curcumin	13-21	heart and neural crest derivatives expressed 2	Mus musculus	118-121
33234350-3	2021	Curcumin (CUR), a polyphenol found in turmeric roots (Curcuma longa) can repress mTORC1 kinase activity in colon cancer cell lines; however, key aspects of CUR mechanism of action remain to be elucidated including its primary cellular target.	Curcumin	10-13	CREB regulated transcription coactivator 1	Mus musculus	81-87
20136422-6	2010	Treatment with curcumin (75 mg/kg body wt) led to a significant decrease in the levels of LPO, enzymic antioxidants, and nonenzymic antioxidants, which were similar to that of control.	Curcumin	15-23	lactoperoxidase	Rattus norvegicus	90-93
28527659-0	2017	Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats.	Curcumin	0-8	acetylcholinesterase	Rattus norvegicus	33-53
28527659-1	2017	Curcumin, the main polyphenolic component of turmeric (Curcuma longa) rhizomes have been reported to exert anticholinesterase potential with limited information on how they regulate acetylcholinesterase (AChE) gene expression.	Curcumin	0-8	acetylcholinesterase	Rattus norvegicus	182-202
28527659-1	2017	Curcumin, the main polyphenolic component of turmeric (Curcuma longa) rhizomes have been reported to exert anticholinesterase potential with limited information on how they regulate acetylcholinesterase (AChE) gene expression.	Curcumin	0-8	acetylcholinesterase	Rattus norvegicus	204-208
28527659-2	2017	Hence, this study sought to evaluate the effect of curcumin on cerebral cortex acetylcholinesterase (AChE) activity and their mRNA gene expression level in cadmium (Cd)-treated rats.	Curcumin	51-59	acetylcholinesterase	Rattus norvegicus	79-99
28527659-2	2017	Hence, this study sought to evaluate the effect of curcumin on cerebral cortex acetylcholinesterase (AChE) activity and their mRNA gene expression level in cadmium (Cd)-treated rats.	Curcumin	51-59	acetylcholinesterase	Rattus norvegicus	101-105
28527659-3	2017	Furthermore, in vitro effect of different concentrations of curcumin (1-5mug/mL) on rat cerebral cortex AChE activity was assessed.	Curcumin	60-68	acetylcholinesterase	Rattus norvegicus	104-108
28527659-8	2017	However, co-treatment with curcumin inhibited AChE activity and alters AChE mRNA levels when compared to Cd-treated group.	Curcumin	27-35	acetylcholinesterase	Rattus norvegicus	46-50
28527659-8	2017	However, co-treatment with curcumin inhibited AChE activity and alters AChE mRNA levels when compared to Cd-treated group.	Curcumin	27-35	acetylcholinesterase	Rattus norvegicus	71-75
29098242-1	2017	PURPOSE: To investigate the effects of lipopolysaccharides(LPS) extracted from Porphyromonas endodontalis(P.e) on the expression of macrophageinflammatoryprotein-1alpha (MIP-1alpha) mRNA and protein levels in MC3T3-E1 cells and the influence of curcumin in the process.	Curcumin	245-253	chemokine (C-C motif) ligand 3	Mus musculus	170-180
29098242-7	2017	The expression of MIP-1alpha mRNA and protein decreased significantly after pretreatment with 10 mumol/L curcumin for 1 h. CONCLUSIONS: The results suggest that P.e-LPS may mediate MIP-1alpha expression in MC3T3-E1 cells, and curcumin has a significant inhibitory effect on this process.	Curcumin	105-113	chemokine (C-C motif) ligand 3	Mus musculus	18-28
29098242-7	2017	The expression of MIP-1alpha mRNA and protein decreased significantly after pretreatment with 10 mumol/L curcumin for 1 h. CONCLUSIONS: The results suggest that P.e-LPS may mediate MIP-1alpha expression in MC3T3-E1 cells, and curcumin has a significant inhibitory effect on this process.	Curcumin	105-113	chemokine (C-C motif) ligand 3	Mus musculus	181-191
29098242-7	2017	The expression of MIP-1alpha mRNA and protein decreased significantly after pretreatment with 10 mumol/L curcumin for 1 h. CONCLUSIONS: The results suggest that P.e-LPS may mediate MIP-1alpha expression in MC3T3-E1 cells, and curcumin has a significant inhibitory effect on this process.	Curcumin	226-234	chemokine (C-C motif) ligand 3	Mus musculus	18-28
29098242-7	2017	The expression of MIP-1alpha mRNA and protein decreased significantly after pretreatment with 10 mumol/L curcumin for 1 h. CONCLUSIONS: The results suggest that P.e-LPS may mediate MIP-1alpha expression in MC3T3-E1 cells, and curcumin has a significant inhibitory effect on this process.	Curcumin	226-234	chemokine (C-C motif) ligand 3	Mus musculus	181-191
28102474-9	2017	However, combination of curcumin and donepezil improves learning and memory activity associated with inhibitory effect on AChE, BuChE, and ADA activities as compared to control.	Curcumin	24-32	acetylcholinesterase	Rattus norvegicus	122-126
28527659-9	2017	In addition, curcumin inhibits rat cerebral cortex AChE activity in vitro.	Curcumin	13-21	acetylcholinesterase	Rattus norvegicus	51-55
28527659-10	2017	In conclusion, curcumin exhibit anti-acetylcholinesterase activity and suppressed AChE mRNA gene expression level in Cd exposed rats, thus providing some biochemical and molecular evidence on the therapeutic effect of this turmeric-derived compound in treating neurological disorders including Alzheimer"s disease.	Curcumin	15-23	acetylcholinesterase	Rattus norvegicus	37-57
28527659-10	2017	In conclusion, curcumin exhibit anti-acetylcholinesterase activity and suppressed AChE mRNA gene expression level in Cd exposed rats, thus providing some biochemical and molecular evidence on the therapeutic effect of this turmeric-derived compound in treating neurological disorders including Alzheimer"s disease.	Curcumin	15-23	acetylcholinesterase	Rattus norvegicus	82-86
34634654-10	2022	Protein expressions of MMP-9, HDAC 1, H3acK9 and NF-kB p65 were modulated in intranasal curcumin and SoB pretreatment groups.	Curcumin	88-96	matrix metallopeptidase 9	Mus musculus	23-28
28660665-11	2017	Finally, using miR-330-5p as an example, we confirmed the role of miR-330-5p in mediating the anti-migration effect of curcumin, suggesting the importance of miRNAs in the regulation of curcumin biological activity.	Curcumin	119-127	microRNA 330	Homo sapiens	15-22
28660665-11	2017	Finally, using miR-330-5p as an example, we confirmed the role of miR-330-5p in mediating the anti-migration effect of curcumin, suggesting the importance of miRNAs in the regulation of curcumin biological activity.	Curcumin	119-127	microRNA 330	Homo sapiens	66-73
28660665-11	2017	Finally, using miR-330-5p as an example, we confirmed the role of miR-330-5p in mediating the anti-migration effect of curcumin, suggesting the importance of miRNAs in the regulation of curcumin biological activity.	Curcumin	186-194	microRNA 330	Homo sapiens	15-22
28660665-11	2017	Finally, using miR-330-5p as an example, we confirmed the role of miR-330-5p in mediating the anti-migration effect of curcumin, suggesting the importance of miRNAs in the regulation of curcumin biological activity.	Curcumin	186-194	microRNA 330	Homo sapiens	66-73
28669709-0	2017	A mechanistic insight into curcumin modulation of the IL-1beta secretion and NLRP3 S-glutathionylation induced by needle-like cationic cellulose nanocrystals in myeloid cells.	Curcumin	27-35	NLR family, pyrin domain containing 3	Mus musculus	77-82
28669709-5	2017	We hypothesize that curcumin may also affect S-glutathionylation of key proteins involved in the NLRP3 inflammasome/IL-1beta pathway, and therefore impact their protein-protein interactions.	Curcumin	20-28	NLR family, pyrin domain containing 3	Mus musculus	97-102
28881600-0	2017	Curcumin induces G2/M cell cycle arrest and apoptosis of head and neck squamous cell carcinoma in vitro and in vivo through ATM/Chk2/p53-dependent pathway.	Curcumin	0-8	ATM serine/threonine kinase	Homo sapiens	124-127
28259934-0	2017	Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5/AP-1 in SV-40 immortalized human urothelial cells.	Curcumin	0-8	mitogen-activated protein kinase 7	Homo sapiens	89-93
28259934-10	2017	Furthermore, curcumin effectively attenuated benzidine-induced urocystic EMT by suppressing ERK5/AP-1 pathway.	Curcumin	13-21	mitogen-activated protein kinase 7	Homo sapiens	92-96
28259934-11	2017	In conclusion, the present study revealed the positive role of ERK5/AP-1 in benzidine-provoked urocystic EMT and the curcumin promising use in bladder cancer prevention and intervention via ERK5/AP-1 pathway.	Curcumin	117-125	mitogen-activated protein kinase 7	Homo sapiens	190-194
28669709-6	2017	The goal of this study was to investigate the effects of curcumin on the S-glutathionylation of NLRP3 induced by CNC-AEMA2 in LPS-primed mouse macrophages (J774A.1), as well as interactions among proteins of the NLRP3 inflammasome complex.	Curcumin	57-65	NLR family, pyrin domain containing 3	Mus musculus	96-101
28669709-7	2017	Our main finding indicates that the addition of curcumin concomitantly with LPS caused the greatest decrease in NLRP3 S-glutathionylation and a respective increase in caspase-1 S-glutathionylation, which appears to favor protein-protein interactions in the NLRP3 complex.	Curcumin	48-56	NLR family, pyrin domain containing 3	Mus musculus	112-117
34957997-0	2021	Curcumin increases crizotinib sensitivity through the inactivation of autophagy via epigenetic modulation of the miR-142-5p/Ulk1 axis in non-small cell lung cancer.	Curcumin	0-8	unc-51 like autophagy activating kinase 1	Homo sapiens	124-128
28669709-7	2017	Our main finding indicates that the addition of curcumin concomitantly with LPS caused the greatest decrease in NLRP3 S-glutathionylation and a respective increase in caspase-1 S-glutathionylation, which appears to favor protein-protein interactions in the NLRP3 complex.	Curcumin	48-56	NLR family, pyrin domain containing 3	Mus musculus	257-262
28669709-8	2017	Taking together, our results suggest that, at least in part, the anti-inflammatory activity of curcumin is associated with changes in S-glutathionylation of key NLRP3 inflammasome components, and perhaps resulting in sustained complex assembly and suppression of IL-1beta secretion.	Curcumin	95-103	NLR family, pyrin domain containing 3	Mus musculus	161-166
28199114-5	2017	In vitro cytotoxicity evaluation against human pancreatic SW1990 cell line showed that the delivery of curcumin in mPEG-PCL-Phe(Boc) micelles to cancer cells was efficient and dosage-dependent.	Curcumin	103-111	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	Mus musculus	115-132
28804605-0	2017	Up-regulation of miR-21 decreases chemotherapeutic effect of dendrosomal curcumin in breast cancer cells.	Curcumin	73-81	microRNA 21	Homo sapiens	17-23
28338387-14	2017	Therefore, natural DNMT1 inhibitors, such as curcumin, can be a novel approach for the neurodegenerative disorders treatment.	Curcumin	45-53	DNA methyltransferase 1	Rattus norvegicus	19-24
34957997-11	2021	Collectively, our findings demonstrate that curcumin sensitizes NSCLC cells to crizotinib by inactivating autophagy through the regulation of miR-142-5p and its target Ulk1.	Curcumin	44-52	unc-51 like autophagy activating kinase 1	Homo sapiens	168-172
28412471-5	2017	Hence, we prepared N-carboxymethyl chitosan (NCC) coated curcumin-loaded SLN (NCC-SLN) to inhibit the rapid release of curcumin in acidic environment and enhance the bioavailability.	Curcumin	57-65	sarcolipin	Homo sapiens	73-76
33843453-0	2021	Nicotinate-curcumin inhibits AngII-induced vascular smooth muscle cell phenotype switching by upregulating Daxx expression.	Curcumin	11-19	death domain associated protein	Homo sapiens	107-111
28412471-5	2017	Hence, we prepared N-carboxymethyl chitosan (NCC) coated curcumin-loaded SLN (NCC-SLN) to inhibit the rapid release of curcumin in acidic environment and enhance the bioavailability.	Curcumin	57-65	sarcolipin	Homo sapiens	78-85
28412471-5	2017	Hence, we prepared N-carboxymethyl chitosan (NCC) coated curcumin-loaded SLN (NCC-SLN) to inhibit the rapid release of curcumin in acidic environment and enhance the bioavailability.	Curcumin	119-127	sarcolipin	Homo sapiens	73-76
28412471-5	2017	Hence, we prepared N-carboxymethyl chitosan (NCC) coated curcumin-loaded SLN (NCC-SLN) to inhibit the rapid release of curcumin in acidic environment and enhance the bioavailability.	Curcumin	119-127	sarcolipin	Homo sapiens	78-85
28412471-8	2017	The lymphatic uptake and oral bioavailability of NCC-SLN were found to be 6.3-fold and 9.5-fold higher than that of curcumin solution, respectively.	Curcumin	116-124	sarcolipin	Homo sapiens	49-56
28412471-9	2017	These results suggest that NCC-SLN could be an efficient oral delivery system for curcumin.	Curcumin	82-90	sarcolipin	Homo sapiens	27-34
28810635-0	2017	Curcumin protects against acute renal injury by suppressing JAK2/STAT3 pathway in severe acute pancreatitis in rats.	Curcumin	0-8	signal transducer and activator of transcription 3	Rattus norvegicus	65-70
28810635-8	2017	Furthermore, curcumin markedly decreased serum TNF-alpha and IL-6 levels and downregulated renal protein levels of JAK2/STAT3 pathway components.	Curcumin	13-21	signal transducer and activator of transcription 3	Rattus norvegicus	120-125
28595079-6	2017	Furthermore, curcumin markedly decreased NAD(P)H oxidase subunits (p67phox, p47phox, p22phox), nitrotyrosine and CYP2E1 renal protein expression as well as reduced pro-inflammatory cytokine expression (TNFalpha, IL-1beta, IFNgamma).	Curcumin	13-21	neutrophil cytosolic factor 1	Mus musculus	76-83
28595079-6	2017	Furthermore, curcumin markedly decreased NAD(P)H oxidase subunits (p67phox, p47phox, p22phox), nitrotyrosine and CYP2E1 renal protein expression as well as reduced pro-inflammatory cytokine expression (TNFalpha, IL-1beta, IFNgamma).	Curcumin	13-21	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	113-119
34717229-6	2021	Curcumin and diacetylcurcumin showed stability and good binding affinity at the active site of the SARS-CoV-2 RdRp-RNA complex.	Curcumin	0-8	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	110-114
28595079-7	2017	Renal protein expression of mitogen activated protein kinases (MAPKs) (p-JNK, p-ERK1/2) and glucose regulated protein 78, CHOP were increased in NASH induced mice and curcumin treatment attenuated these increased expressions.	Curcumin	167-175	DNA-damage inducible transcript 3	Mus musculus	122-126
28391184-6	2017	Exposure to curcumin and resveratrol promoted TRX1 oxidation and altered its subcellular location.	Curcumin	12-20	thioredoxin	Homo sapiens	46-50
28702620-3	2017	Ceria nanoparticles, coated with dextran and loaded with curcumin, were found to induce substantial cell death in neuroblastoma cells (up to a 2-fold and a 1.6-fold decrease in cell viability for MYCN-upregulated and normal expressing cell lines, respectively; *p &lt; 0.05) while producing no or only minor toxicity in healthy cells (no toxicity at 100 muM; **p &lt; 0.01).	Curcumin	57-65	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	196-200
34174648-0	2021	Development of pH-driven zein/tea saponin composite nanoparticles for encapsulation and oral delivery of curcumin.	Curcumin	105-113	phenylalanine hydroxylase	Homo sapiens	15-17
28725008-7	2017	In silico studies of interactions between curcumin or gingerol and myostatin (MSTN; an inhibitor of myogenesis) and their observed affinities for activin receptor type IIB (ACVRIIB) suggested curcumin and gingerol reduce the interaction between MSTN and ACVRIIB.	Curcumin	42-50	myostatin	Mus musculus	67-76
28725008-7	2017	In silico studies of interactions between curcumin or gingerol and myostatin (MSTN; an inhibitor of myogenesis) and their observed affinities for activin receptor type IIB (ACVRIIB) suggested curcumin and gingerol reduce the interaction between MSTN and ACVRIIB.	Curcumin	192-200	myostatin	Mus musculus	78-82
28448872-0	2017	Curcumin attenuates lipopolysaccharide/d-galactosamine-induced acute liver injury by activating Nrf2 nuclear translocation and inhibiting NF-kB activation.	Curcumin	0-8	nuclear factor kappa B subunit 1	Rattus norvegicus	138-143
34626726-0	2021	An anti-DR5 antibody-curcumin conjugate for the enhanced clearance of activated hepatic stellate cells.	Curcumin	21-29	tumor necrosis factor receptor superfamily, member 10b	Mus musculus	8-11
28705118-9	2017	The effects of curcumin on expression levels of beta-catenin and epithelial-mesenchymal transition marker were determined by western blotting.	Curcumin	15-23	catenin beta 1	Homo sapiens	48-60
34626726-3	2021	In this study, an anti-DR5 antibody-curcumin conjugate (DCC) was prepared to investigate its effect on the clearance of activated HSCs.	Curcumin	36-44	tumor necrosis factor receptor superfamily, member 10b	Mus musculus	23-26
28705118-11	2017	Furthermore, curcumin inhibited the cell proliferation of T24 and 5637 cells, and curcumin reduced the migration and invasive ability of T24 and 5637 cells via regulating beta-catenin expression and reversing epithelial-mesenchymal transition.	Curcumin	82-90	catenin beta 1	Homo sapiens	171-183
34626726-4	2021	The DCC was synthesized through a coupling reaction between a maleimide-functionalized curcumin derivative and a thiolated anti-DR5 antibody.	Curcumin	87-95	tumor necrosis factor receptor superfamily, member 10b	Mus musculus	128-131
34626726-6	2021	Owing to the antioxidant and anti-inflammatory effects of curcumin, DCC-treated HSCs produced much lower levels of reactive oxygen species and inducible nitric oxide synthase than the bare anti-DR5 antibody-treated HSCs.	Curcumin	58-66	tumor necrosis factor receptor superfamily, member 10b	Mus musculus	194-197
34751624-5	2021	Curcumin significantly downregulated the TGF-beta1, P-Smad2/3, cleaved caspase-3, cleaved caspase-8 and Dragon levels.	Curcumin	0-8	caspase 3	Rattus norvegicus	71-80
34887767-0	2021	The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation.	Curcumin	25-33	microphthalmia-associated transcription factor	Cavia porcellus	121-125
34828017-6	2021	The expression levels of apoptotic genes or proteins in either pro-apoptosis (CASP3 and FAS) or anti-apoptosis (BCL2, BCL2L1, and CFLAR) were significantly manipulated by the effects of either quercetin or curcumin.	Curcumin	206-214	caspase 3	Bos taurus	78-83
34116430-3	2021	The physicochemical and structural properties of the CMKGM/CS nanogels and their potential to be a delivery vehicle for curcumin were investigated.	Curcumin	120-128	citrate synthase	Homo sapiens	59-61
34758851-0	2021	Curcumin prevents As3+-induced carcinogenesis through regulation of GSK3beta/Nrf2.	Curcumin	0-8	glycogen synthase kinase 3 alpha	Homo sapiens	68-76
34758851-8	2021	Moreover, curcumin induced autophagy in As3+-treated BEAS-2B via inducing autophagy by the formation of a p62/LC-3 complex and increasing autophagic flux by promoting transcription factor EB (TFEB) and lysosome-associated membrane protein 1 (LAMP1) expression.	Curcumin	10-18	transcription factor EB	Homo sapiens	167-190
34758851-8	2021	Moreover, curcumin induced autophagy in As3+-treated BEAS-2B via inducing autophagy by the formation of a p62/LC-3 complex and increasing autophagic flux by promoting transcription factor EB (TFEB) and lysosome-associated membrane protein 1 (LAMP1) expression.	Curcumin	10-18	transcription factor EB	Homo sapiens	192-196
34758851-8	2021	Moreover, curcumin induced autophagy in As3+-treated BEAS-2B via inducing autophagy by the formation of a p62/LC-3 complex and increasing autophagic flux by promoting transcription factor EB (TFEB) and lysosome-associated membrane protein 1 (LAMP1) expression.	Curcumin	10-18	lysosomal associated membrane protein 1	Homo sapiens	202-240
34758851-8	2021	Moreover, curcumin induced autophagy in As3+-treated BEAS-2B via inducing autophagy by the formation of a p62/LC-3 complex and increasing autophagic flux by promoting transcription factor EB (TFEB) and lysosome-associated membrane protein 1 (LAMP1) expression.	Curcumin	10-18	lysosomal associated membrane protein 1	Homo sapiens	242-247
34758851-14	2021	Further studies showed that curcumin decreased the Nrf2 level in AsT by activating GSK-3beta to inhibit the activation of PI3K/AKT.	Curcumin	28-36	glycogen synthase kinase 3 alpha	Homo sapiens	83-92
34758851-15	2021	Co-IP assay results showed that curcumin promoted the interaction of Nrf2 with the GSK-3beta/beta-TrCP axis and ubiquitin.	Curcumin	32-40	glycogen synthase kinase 3 alpha	Homo sapiens	83-92
34758851-16	2021	Moreover, the inhibition of GSK-3beta reversed Nrf2 expression in curcumin-treated AsT, indicating that the decrease in Nrf2 is due to activation of the GSK-3beta/beta-TrCP ubiquitination pathway.	Curcumin	66-74	glycogen synthase kinase 3 alpha	Homo sapiens	28-37
34758851-16	2021	Moreover, the inhibition of GSK-3beta reversed Nrf2 expression in curcumin-treated AsT, indicating that the decrease in Nrf2 is due to activation of the GSK-3beta/beta-TrCP ubiquitination pathway.	Curcumin	66-74	glycogen synthase kinase 3 alpha	Homo sapiens	153-162
34510720-5	2021	Curcumin supplementation significantly reduced adiposity and total macrophage infiltration in WAT, compared to HFD group, consistent with reduced mRNA levels of M1 (Cd80, Cd38, Cd11c) and M2 (Arginase-1) macrophage markers.	Curcumin	0-8	integrin alpha X	Mus musculus	177-182
34510720-5	2021	Curcumin supplementation significantly reduced adiposity and total macrophage infiltration in WAT, compared to HFD group, consistent with reduced mRNA levels of M1 (Cd80, Cd38, Cd11c) and M2 (Arginase-1) macrophage markers.	Curcumin	0-8	arginase, liver	Mus musculus	192-202
34541720-7	2021	Serum levels of IFN-gamma (p = .52) and IL-17 (p = .11) decreased, while IL-4 (p = .12) and TGF-beta (p = .14) increased in the nano-curcumin group compared with placebo on day 14.	Curcumin	133-141	transforming growth factor alpha	Homo sapiens	92-100
34541720-8	2021	Moreover, gene expressions of TBX21 (p = .02) and FOXP3 (p = .005) genes were significantly decreased and increased between nano-curcumin and placebo groups on day 7, respectively.	Curcumin	129-137	forkhead box P3	Homo sapiens	50-55
34692517-13	2021	Curcumin also uplifted the SDH expression, which was inhibited in high glucose condition.	Curcumin	0-8	serine dehydratase	Homo sapiens	27-30
26910813-0	2017	Curcumin Ameliorates Memory Decline via Inhibiting BACE1 Expression and beta-Amyloid Pathology in 5xFAD Transgenic Mice.	Curcumin	0-8	beta-site APP cleaving enzyme 1	Mus musculus	51-56
34233590-8	2021	In addition, curcumin significantly inhibited the protein expression of IL-6R, STAT3, snail, survivin, and cyclin D1 in THLE-2 and HepG2 cells induced by IL-6.	Curcumin	13-21	cyclin D1	Homo sapiens	107-116
26910813-5	2017	Our results showed that curcumin administration (150 or 300 mg/kg/day, intragastrically, for 60 days) dramatically reduced Abeta production by downregulating BACE1 expression, preventing synaptic degradation, and improving spatial learning and memory impairment of 5xFAD mice.	Curcumin	24-32	amyloid beta (A4) precursor protein	Mus musculus	123-128
26910813-5	2017	Our results showed that curcumin administration (150 or 300 mg/kg/day, intragastrically, for 60 days) dramatically reduced Abeta production by downregulating BACE1 expression, preventing synaptic degradation, and improving spatial learning and memory impairment of 5xFAD mice.	Curcumin	24-32	beta-site APP cleaving enzyme 1	Mus musculus	158-163
34586536-2	2022	The purpose from this study was to determine effects of curcumin nanoparticle into phytosomal formulation (PC) on the relative expression of DSPP, VEGF-A, HLA-G5, VCAM1, RelA and STAT3 genes which are among the most important factors influencing processes of immunomodulatory and tissue regenerative by DPSCs.	Curcumin	56-64	dentin sialophosphoprotein	Homo sapiens	141-145
28350049-0	2017	Activation of the CRABPII/RAR pathway by curcumin induces retinoic acid mediated apoptosis in retinoic acid resistant breast cancer cells.	Curcumin	41-49	retinoic acid receptor alpha	Homo sapiens	26-29
28350049-7	2017	Co-treatment of the cells with curcumin and RA results in increased apoptosis as demonstrated by elevated cleavage of poly(ADP-ribose) polymerase and cleaved caspase-9.	Curcumin	31-39	caspase 9	Homo sapiens	158-167
34586536-2	2022	The purpose from this study was to determine effects of curcumin nanoparticle into phytosomal formulation (PC) on the relative expression of DSPP, VEGF-A, HLA-G5, VCAM1, RelA and STAT3 genes which are among the most important factors influencing processes of immunomodulatory and tissue regenerative by DPSCs.	Curcumin	56-64	RELA proto-oncogene, NF-kB subunit	Homo sapiens	170-174
28350049-9	2017	These findings provide mechanistic insights into sensitizing TNBC cells to RA-mediated cell death by curcumin-induced upregulation of the CRABPII/RAR pathway.	Curcumin	101-109	retinoic acid receptor alpha	Homo sapiens	146-149
28198062-0	2017	Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/beta-catenin and Sonic Hedgehog Pathways.	Curcumin	0-8	catenin beta 1	Homo sapiens	62-74
34577062-0	2021	Curcumin and Nano-Curcumin Mitigate Copper Neurotoxicity by Modulating Oxidative Stress, Inflammation, and Akt/GSK-3beta Signaling.	Curcumin	0-8	glycogen synthase kinase 3 alpha	Rattus norvegicus	111-120
28198062-9	2017	Moreover, we demonstrated that curcumin suppressed the activation of both Wnt/beta-catenin and Sonic Hedgehog pathways.	Curcumin	31-39	catenin beta 1	Homo sapiens	78-90
28198062-10	2017	Taken together, our data suggested that curcumin exhibited its interventional effect on lung CSCs via inhibition of Wnt/beta-catenin and Sonic Hedgehog pathways.	Curcumin	40-48	catenin beta 1	Homo sapiens	120-132
34577062-0	2021	Curcumin and Nano-Curcumin Mitigate Copper Neurotoxicity by Modulating Oxidative Stress, Inflammation, and Akt/GSK-3beta Signaling.	Curcumin	18-26	glycogen synthase kinase 3 alpha	Rattus norvegicus	111-120
28377722-10	2017	Atg5-knockdown also abolished the beneficial effects of curcumin on palmitate-induced ER stress, JNK/IRS-1 pathway as well as insulin signaling.	Curcumin	56-64	insulin receptor substrate 1	Homo sapiens	101-106
34574194-5	2021	Some of these compounds (e.g., curcumin, gallic acid or quercetin) already showed capacity to limit the infection of viruses by inhibiting entry into the cell through its binding to protein Spike, regulating the expression of angiotensin-converting enzyme 2, disrupting the replication in cells by inhibition of viral proteases, and/or suppressing and modulating the host"s immune response.	Curcumin	31-39	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	190-195
28198625-4	2017	According to the histopathological examination of liver tissues and biomarker detection in serum and livers, it was demonstrated that curcumin attenuated DEN-induced hepatocarcinogenesis through parts of regulating the oxidant stress enzymes (T-SOD and CAT), liver function (ALT and AST) and LDHA, AFP level, and COX-2/PGE2 pathway.	Curcumin	134-142	glutamic pyruvic transaminase, soluble	Mus musculus	275-278
28198625-5	2017	Furthermore, curcumin attenuated metabolic disorders via increasing concentration of glucose and fructose, and decreasing levels of glycine and proline, and mRNA expression of GLUT1, PKM and FASN.	Curcumin	13-21	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	176-181
28198625-6	2017	Docking study indicated that curcumin presented strong affinity with key metabolism enzymes such as GLUT1, PKM, FASN and LDHA.	Curcumin	29-37	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	100-105
28124574-9	2017	The results showed that curcumin ameliorated the defective insulin signalling pathway by upregulating insulin-like growth factor (IGF)-1R, IRS-2, PI3K, p-PI3K, Akt and p-Akt protein expression while downregulating IR and IRS-1.	Curcumin	24-32	insulin receptor substrate 2	Mus musculus	139-144
28124574-9	2017	The results showed that curcumin ameliorated the defective insulin signalling pathway by upregulating insulin-like growth factor (IGF)-1R, IRS-2, PI3K, p-PI3K, Akt and p-Akt protein expression while downregulating IR and IRS-1.	Curcumin	24-32	insulin receptor substrate 1	Mus musculus	221-226
28196290-5	2017	Enzyme-linked immunosorbent assay (ELISA) and real-time quantitative polymerase chain reaction (qRT-PCR) showed that curcumin could reduce c-reaction protein levels and inflammatory cytokine (TNF-alpha, IL-1beta, IL-6, and CINC-1/IL-8) concentrations in peripheral serum and liver tissue.	Curcumin	117-125	C-X-C motif chemokine ligand 1	Rattus norvegicus	223-229
34574194-5	2021	Some of these compounds (e.g., curcumin, gallic acid or quercetin) already showed capacity to limit the infection of viruses by inhibiting entry into the cell through its binding to protein Spike, regulating the expression of angiotensin-converting enzyme 2, disrupting the replication in cells by inhibition of viral proteases, and/or suppressing and modulating the host"s immune response.	Curcumin	31-39	angiotensin converting enzyme 2	Homo sapiens	226-257
34198046-7	2021	Several trends were identified from the proteomic subset which revealed that IL-17A induces expressions of proteins like MCM2, MCM3, and MCM6 along with other proteins involved in DR. Interestingly, curcumin was found in suppressing the expression levels of these proteins.	Curcumin	199-207	minichromosome maintenance complex component 3	Mus musculus	127-131
34198046-10	2021	Apart from this, the present study also reports the unique contribution of curcumin in suppressing the mRNA levels of other MCMs like MCM4, MCM5, and MCM7 as well as of ORC1 and ORC2.	Curcumin	75-83	origin recognition complex, subunit 2	Mus musculus	178-182
34335911-0	2021	Curcumin inhibits prostate cancer progression by regulating the miR-30a-5p/PCLAF axis.	Curcumin	0-8	microRNA 30a	Homo sapiens	64-71
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	214-222	solute carrier family 22 member 6	Homo sapiens	269-273
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	214-222	solute carrier family 22 member 8	Homo sapiens	279-283
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	214-222	solute carrier organic anion transporter family member 1B1	Homo sapiens	312-319
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	214-222	solute carrier family 22 member 8	Homo sapiens	334-338
27174018-8	2017	Inhibition study using rosuvastatin as the substrate in OATP1B1- and OATP1B3-transfected cells indicated that curcumin was an OATP1B1 and 1B3 inhibitor, with IC50 at 5.19 +- 0.05 and 3.68 +- 0.05 muM, respectively; the data for COG were 1.04 +- 0.01 and 1.08 +- 0.02 muM, respectively.	Curcumin	110-118	solute carrier organic anion transporter family member 1B1	Homo sapiens	56-63
27174018-8	2017	Inhibition study using rosuvastatin as the substrate in OATP1B1- and OATP1B3-transfected cells indicated that curcumin was an OATP1B1 and 1B3 inhibitor, with IC50 at 5.19 +- 0.05 and 3.68 +- 0.05 muM, respectively; the data for COG were 1.04 +- 0.01 and 1.08 +- 0.02 muM, respectively.	Curcumin	110-118	solute carrier organic anion transporter family member 1B1	Homo sapiens	126-133
28231299-5	2017	Therefore, we suggest miR-34a-5p/miR-34c-5p/miR-302b-3p -LEF1-CCND1/WNT1/MYC axis may be a crucial mechanism in inhibition of lung cancer metastasis by curcumin.	Curcumin	152-160	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	73-76
27743775-0	2017	Curcumin as a natural regulator of monocyte chemoattractant protein-1.	Curcumin	0-8	C-C motif chemokine ligand 2	Homo sapiens	35-69
27743775-5	2017	The purpose of this review is to evaluate the effects of curcumin on the regulation of MCP-1 as a key mediator of chemotaxis and inflammation, and the biological consequences thereof.	Curcumin	57-65	C-C motif chemokine ligand 2	Homo sapiens	87-92
27743775-7	2017	Animal studies have also revealed that curcumin can attenuate MCP-1 expression and improve a range of inflammatory diseases through multiple molecular targets and mechanisms of action.	Curcumin	39-47	C-C motif chemokine ligand 2	Homo sapiens	62-67
27743775-8	2017	There is limited data from human clinical trials showing the decreasing effect of curcumin on MCP-1 concentrations and improvement of the course of inflammatory diseases.	Curcumin	82-90	C-C motif chemokine ligand 2	Homo sapiens	94-99
27743775-9	2017	Most of the in vitro and animal studies confirm that curcumin exert its MCP-1-lowering and anti-inflammatory effects by down-regulating the mitogen-activated protein kinase (MAPK) and NF-kappaB signaling pathway.	Curcumin	53-61	C-C motif chemokine ligand 2	Homo sapiens	72-77
27743775-10	2017	As yet, there is limited data from human clinical trials showing the effect of curcumin on MCP-1 levels and improvement of the course of inflammatory diseases.	Curcumin	79-87	C-C motif chemokine ligand 2	Homo sapiens	91-96
27237942-11	2017	Enemas containing curcumin improved the inflammation of the mucosa without a faecal stream and reduced the tissue contents of MPO.	Curcumin	18-26	myeloperoxidase	Rattus norvegicus	126-129
27237942-13	2017	Enemas with curcumin improved the inflammation of the colonic mucosa, reduced the inflammatory grade and decreased the tissue content of MPO in colon segments without a faecal stream.	Curcumin	12-20	myeloperoxidase	Rattus norvegicus	137-140
27894665-8	2017	Curcumin supplementation inhibited FasL mRNA production and up-regulated the expression of pro-apoptotic molecules granzyme A (at the mRNA level) and granulysin (at the protein level), suggesting degranulation of granulysin-bearing cells following curcumin supplementation.	Curcumin	0-8	Fas ligand	Homo sapiens	35-39
28194406-0	2017	Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	57-62
28194406-6	2017	Furthermore, the upregulated protein and mRNA expressions of collagen IV and fibronectin in the renal cortices of the db/db mice were inhibited by curcumin treatment.	Curcumin	147-155	fibronectin 1	Mus musculus	77-88
28194406-7	2017	Additionally, curcumin treatment was associated with significant reductions in mature interleukin-1beta, cleaved caspase-1, and NLRP3 protein levels in the renal cortices of db/db mice as well as in HK-2 cells exposed to high glucose concentration.	Curcumin	14-22	NLR family, pyrin domain containing 3	Mus musculus	128-133
28194406-8	2017	In summary, curcumin, a potent antifibrotic agent, is a promising treatment for DN, and its renoprotective effects appear to be mediated by the inhibition of NLRP3 inflammasome activity.	Curcumin	12-20	NLR family, pyrin domain containing 3	Mus musculus	158-163
29069652-11	2017	CONCLUSION: This study suggests that curcumin could protect against oxidative stress-induced injury in PD rats via the Wnt/beta-catenin signaling pathway.	Curcumin	37-45	catenin beta 1	Rattus norvegicus	123-135
28678631-11	2017	Curcumin treatment inhibited phosphorylated c-Jun N-terminal kinase (JNK) expression in SHR after retinal I/R injury.	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	44-67
28678631-11	2017	Curcumin treatment inhibited phosphorylated c-Jun N-terminal kinase (JNK) expression in SHR after retinal I/R injury.	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	69-72
27608133-0	2017	A systems biology approach for elucidating the interaction of curcumin with Fanconi anemia FANC G protein and the key disease targets of leukemia.	Curcumin	62-70	FA complementation group G	Homo sapiens	91-97
27608133-7	2017	Herein, a systems biology approach for elucidating the therapeutic potential of curcumin against FA and leukemia is investigated by analyzing the computational molecular interactions of curcumin ligand with FANC G of FA and seven other key disease targets of leukemia.	Curcumin	80-88	FA complementation group G	Homo sapiens	207-213
27608133-7	2017	Herein, a systems biology approach for elucidating the therapeutic potential of curcumin against FA and leukemia is investigated by analyzing the computational molecular interactions of curcumin ligand with FANC G of FA and seven other key disease targets of leukemia.	Curcumin	186-194	FA complementation group G	Homo sapiens	207-213
27608133-9	2017	The docking investigations showed that curcumin had a very high binding affinity of -8.1 kcal/mol with FANC G protein.	Curcumin	39-47	FA complementation group G	Homo sapiens	103-109
27608133-10	2017	The key disease targets of leukemia namely tyrosine kinase (ABL1), aurora-like kinase (AUKRB), and polo-like kinase (PLK-2) showed that they had the comparable binding affinities of -9.7 k cal/mol, -8.7 k cal/mol, and -8.6 k cal/mol, respectively with curcumin.	Curcumin	252-260	polo like kinase 2	Homo sapiens	117-122
28224377-5	2017	Curcumin also increased brain-derived neurotrophic factor (BDNF)-positive area and expression of pAkt in the brain, suggesting that curcumin activated BDNF signaling in aged mice.	Curcumin	0-8	brain derived neurotrophic factor	Mus musculus	24-57
28224377-5	2017	Curcumin also increased brain-derived neurotrophic factor (BDNF)-positive area and expression of pAkt in the brain, suggesting that curcumin activated BDNF signaling in aged mice.	Curcumin	0-8	brain derived neurotrophic factor	Mus musculus	59-63
28224377-5	2017	Curcumin also increased brain-derived neurotrophic factor (BDNF)-positive area and expression of pAkt in the brain, suggesting that curcumin activated BDNF signaling in aged mice.	Curcumin	0-8	brain derived neurotrophic factor	Mus musculus	151-155
28224377-5	2017	Curcumin also increased brain-derived neurotrophic factor (BDNF)-positive area and expression of pAkt in the brain, suggesting that curcumin activated BDNF signaling in aged mice.	Curcumin	132-140	brain derived neurotrophic factor	Mus musculus	24-57
28224377-5	2017	Curcumin also increased brain-derived neurotrophic factor (BDNF)-positive area and expression of pAkt in the brain, suggesting that curcumin activated BDNF signaling in aged mice.	Curcumin	132-140	brain derived neurotrophic factor	Mus musculus	59-63
28224377-5	2017	Curcumin also increased brain-derived neurotrophic factor (BDNF)-positive area and expression of pAkt in the brain, suggesting that curcumin activated BDNF signaling in aged mice.	Curcumin	132-140	brain derived neurotrophic factor	Mus musculus	151-155
28224377-7	2017	These results strongly suggested that curcumin prevented cognitive impairments via multiple targets, possibly by increasing the activity of anti-oxidant enzymes, activation of BDNF signaling, and neutralization of cholinergic dysfunction, concurrently.	Curcumin	38-46	brain derived neurotrophic factor	Mus musculus	176-180
28496336-0	2017	Curcumin exerts its antitumor activity through regulation of miR-7/Skp2/p21 in nasopharyngeal carcinoma cells.	Curcumin	0-8	H3 histone pseudogene 16	Homo sapiens	72-75
28391351-0	2017	Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axis.	Curcumin	0-8	phosphoglycerate kinase 1	Homo sapiens	47-51
28391351-2	2017	The objective of this study was to explore the interaction between curcumin and PGK1, an oncogene in the FOXD3/miR-143 axis, in prostate cancer therapy.	Curcumin	67-75	phosphoglycerate kinase 1	Homo sapiens	80-84
28387563-0	2017	Curcumin Upregulates Antioxidant Defense, Lon Protease, and Heat-Shock Protein 70 Under Hyperglycemic Conditions in Human Hepatoma Cells.	Curcumin	0-8	lon peptidase 1, mitochondrial	Homo sapiens	42-54
28653935-0	2017	Impact of bovine and human serum albumin on Curcumin in vitro activity against Staphylococcus aureus.	Curcumin	44-52	albumin	Bos taurus	27-40
28653935-1	2017	This study evaluated the impact of pH (7.4 and 6.5), bovine serum albumin (BSA), and human serum albumin (HSA) on Curcumin activity against 2 reference, 1 clinical, and 10 environmental strains of Staphylococcus aureus (S. aureus).	Curcumin	114-122	albumin	Bos taurus	60-73
28653935-1	2017	This study evaluated the impact of pH (7.4 and 6.5), bovine serum albumin (BSA), and human serum albumin (HSA) on Curcumin activity against 2 reference, 1 clinical, and 10 environmental strains of Staphylococcus aureus (S. aureus).	Curcumin	114-122	albumin	Bos taurus	91-104
28439402-5	2017	Curcumin also decreased the cleaved caspase-3 (CC3) protein expression level and increased the Bcl-2/Bax ratio in H2O2-stimulated H9c2 cells.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	101-104
28469791-9	2017	The results also revealed that Foxp3 bound T-bet to prevent IFN-gamma expression in CD4+ T cells, which was abolished by treating with curcumin.	Curcumin	135-143	T-box transcription factor 21	Homo sapiens	43-48
28167449-7	2017	Potential anti-cancer activity of curcumin and its analogues is also mediated by modulation of miRNAs such as miR21, that is implicated in cell cycle regulation and apoptosis through down-regulation of PTEN and PDCD4 proteins.	Curcumin	34-42	microRNA 21	Homo sapiens	110-115
28167449-7	2017	Potential anti-cancer activity of curcumin and its analogues is also mediated by modulation of miRNAs such as miR21, that is implicated in cell cycle regulation and apoptosis through down-regulation of PTEN and PDCD4 proteins.	Curcumin	34-42	phosphatase and tensin homolog	Homo sapiens	202-206
29515638-0	2017	The HER-2 as a Target Gene of Curcumin to Protect Hepatocytes Against the Arsenic-induced Carcinoma in Mice.	Curcumin	30-38	erb-b2 receptor tyrosine kinase 2	Mus musculus	4-9
29515638-2	2017	The current study hypothesized that curcumin downregulates HER-2 and inhibits the signal transduction pathway of PI3K/Akt, MAPK, and activation of NFkappaB, which could be useful to treat overexpressed-HER-2 hepatocellular carcinoma (HCC).	Curcumin	36-44	erb-b2 receptor tyrosine kinase 2	Mus musculus	59-64
29515638-2	2017	The current study hypothesized that curcumin downregulates HER-2 and inhibits the signal transduction pathway of PI3K/Akt, MAPK, and activation of NFkappaB, which could be useful to treat overexpressed-HER-2 hepatocellular carcinoma (HCC).	Curcumin	36-44	erb-b2 receptor tyrosine kinase 2	Mus musculus	202-207
29515638-6	2017	Results: Gene expression analysis showed that curcumin had significantly downregulated the activity of HER-2, in poisoned mice.	Curcumin	46-54	erb-b2 receptor tyrosine kinase 2	Mus musculus	103-108
29515638-7	2017	Conclusion: According to the current study results, it could be concluded that curcumin has the inhibitory potential toward HER-2-overexpressed HCC.	Curcumin	79-87	erb-b2 receptor tyrosine kinase 2	Mus musculus	124-129
27743319-6	2017	Our results showed that co-stimulation using LPS and CCM can significantly enhance the activation of OECs, displaying a remarkable up-regulation in chemokine (C-X-C motif) ligand 1, chemokine (C-X-C motif) ligand 2, tumor necrosis factor-alpha, and Toll-like receptor 4, increased OEC proliferative activity, and improved phagocytic capacity compared with normal and LPS- or CCM-treated OECs.	Curcumin	53-56	C-X-C motif chemokine ligand 2	Homo sapiens	159-243
27743319-6	2017	Our results showed that co-stimulation using LPS and CCM can significantly enhance the activation of OECs, displaying a remarkable up-regulation in chemokine (C-X-C motif) ligand 1, chemokine (C-X-C motif) ligand 2, tumor necrosis factor-alpha, and Toll-like receptor 4, increased OEC proliferative activity, and improved phagocytic capacity compared with normal and LPS- or CCM-treated OECs.	Curcumin	53-56	toll like receptor 4	Homo sapiens	249-269
28491145-0	2017	Combination of metformin and curcumin targets breast cancer in mice by angiogenesis inhibition, immune system modulation and induction of p53 independent apoptosis.	Curcumin	29-37	transformation related protein 53	Mus musculus	138-141
28978008-7	2017	Furthermore, inhibition of NFkappaB with its inhibitors (curcumin or Bay) significantly reduced the expression of uPAR and cell migration in the CFTR-overexpressing ISK cells.	Curcumin	57-65	plasminogen activator, urokinase receptor	Homo sapiens	114-118
28095363-0	2017	Curcumin confers neuroprotection against alcohol-induced hippocampal neurodegeneration via CREB-BDNF pathway in rats.	Curcumin	0-8	cAMP responsive element binding protein 1	Rattus norvegicus	91-95
28095363-18	2017	CONCLUSION: Curcumin can act as a neuroprotective agent against neurodegenerative effects of alcohol abuse, probably via activation of CREB-BDNF signaling pathway.	Curcumin	12-20	cAMP responsive element binding protein 1	Rattus norvegicus	135-139
28175963-0	2017	Curcumin suppresses cisplatin resistance development partly via modulating extracellular vesicle-mediated transfer of MEG3 and miR-214 in ovarian cancer.	Curcumin	0-8	maternally expressed 3	Homo sapiens	118-122
28175963-3	2017	Curcumin"s effect on MEG3 promoter methylation and MEG3 expression were studied by MSP and qRT-PCR, respectively.	Curcumin	0-8	maternally expressed 3	Homo sapiens	21-25
28175963-3	2017	Curcumin"s effect on MEG3 promoter methylation and MEG3 expression were studied by MSP and qRT-PCR, respectively.	Curcumin	0-8	maternally expressed 3	Homo sapiens	51-55
28175963-7	2017	Curcumin led to demethylation in the promoter region of MEG3 and 5-AZA-dC treatment restored MEG3 expression in a dose dependent manner.	Curcumin	0-8	maternally expressed 3	Homo sapiens	56-60
28175963-7	2017	Curcumin led to demethylation in the promoter region of MEG3 and 5-AZA-dC treatment restored MEG3 expression in a dose dependent manner.	Curcumin	0-8	maternally expressed 3	Homo sapiens	93-97
28175963-9	2017	MEG3 restoration by curcumin significantly reduced miR-214 in cells and in EVs.	Curcumin	20-28	maternally expressed 3	Homo sapiens	0-4
28175963-11	2017	CONCLUSION: Curcumin can restore MEG3 levels via demethylation.	Curcumin	12-20	maternally expressed 3	Homo sapiens	33-37
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	20-28	solute carrier organic anion transporter family member 1B1	Homo sapiens	242-249
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	20-28	solute carrier organic anion transporter family member 2B1	Homo sapiens	260-267
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	20-28	solute carrier family 22 member 6	Homo sapiens	269-273
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	20-28	solute carrier family 22 member 8	Homo sapiens	279-283
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	20-28	solute carrier organic anion transporter family member 1B1	Homo sapiens	312-319
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	20-28	solute carrier family 22 member 8	Homo sapiens	334-338
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	214-222	solute carrier organic anion transporter family member 1B1	Homo sapiens	242-249
27174018-6	2017	The accumulation of curcumin significantly increased in organic anion transporting polypeptide (OATP)- and organic anion transporter (OAT)-transfected human embryonic kidney (HEK) 293 systems, which suggested that curcumin was a substrate of OATP1B1, OATP1B3, OATP2B1, OAT1, and OAT3; and COG was a substrate of OATP1B1, OATP1B3, and OAT3.	Curcumin	214-222	solute carrier organic anion transporter family member 2B1	Homo sapiens	260-267
28195164-5	2017	Furthermore, both curcumin and L61 down-regulated the expression and function of P-gp in response to drug efflux from the MCF-7/ADR cells.	Curcumin	18-26	phosphoglycolate phosphatase	Homo sapiens	81-85
28179291-9	2017	AS-IV and curcumin alone up-regulated expression of miR-122 and down-regulated that of miR-221.	Curcumin	10-18	microRNA 221	Homo sapiens	87-94
27491636-2	2017	Hence, this study sought to evaluate the effect of curcumin on cerebral cortex acetylcholinesterase (AChE) and adenosine deaminase (ADA) activities in cadmium (Cd)-induced memory impairment in rats.	Curcumin	51-59	acetylcholinesterase	Rattus norvegicus	79-99
27491636-2	2017	Hence, this study sought to evaluate the effect of curcumin on cerebral cortex acetylcholinesterase (AChE) and adenosine deaminase (ADA) activities in cadmium (Cd)-induced memory impairment in rats.	Curcumin	51-59	acetylcholinesterase	Rattus norvegicus	101-105
28222671-0	2017	Reversal of hypermethylation and reactivation of glutathione S-transferase pi 1 gene by curcumin in breast cancer cell line.	Curcumin	88-96	glutathione S-transferase pi 1	Homo sapiens	49-79
28222671-6	2017	To check the effect of curcumin on the methylation pattern of glutathione S-transferase pi 1 gene in MCF-7 breast cancer cell line in dose-dependent manner.	Curcumin	23-31	glutathione S-transferase pi 1	Homo sapiens	62-92
28222671-7	2017	To check the reversal of methylation pattern of hypermethylated glutathione S-transferase pi 1, MCF-7 breast cancer cell line was treated with different concentrations of curcumin for different time periods.	Curcumin	171-179	glutathione S-transferase pi 1	Homo sapiens	64-94
28222671-9	2017	A very low and a nontoxic concentration (10 microM) of curcumin treatment was able to reverse the hypermethylation and led to reactivation of glutathione S-transferase pi 1 protein expression in MCF-7 cells after 72 h of treatment, although the IC50 value of curcumin was found to be at 20 microM.	Curcumin	55-63	glutathione S-transferase pi 1	Homo sapiens	142-172
28222671-11	2017	Treatment of breast cancer MCF-7 cells with curcumin causes complete reversal of glutathione S-transferase pi 1 promoter hypermethylation and leads to re-expression of glutathione S-transferase pi 1, suggesting it to be an excellent nontoxic hypomethylating agent.	Curcumin	44-52	glutathione S-transferase pi 1	Homo sapiens	81-111
28222671-11	2017	Treatment of breast cancer MCF-7 cells with curcumin causes complete reversal of glutathione S-transferase pi 1 promoter hypermethylation and leads to re-expression of glutathione S-transferase pi 1, suggesting it to be an excellent nontoxic hypomethylating agent.	Curcumin	44-52	glutathione S-transferase pi 1	Homo sapiens	168-198
28000447-0	2017	Hypocholesterolemic Activity of Curcumin Is Mediated by Down-regulating the Expression of Niemann-Pick C1-like 1 in Hamsters.	Curcumin	32-40	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	90-112
28000447-1	2017	We previously demonstrated that curcumin reduces cholesterol absorption in Caco-2 cells through down-regulating Niemann-Pick C1-like 1 (NPC1L1) expression, but the in vivo effect of curcumin on intestinal cholesterol absorption remains unknown.	Curcumin	32-40	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	112-134
28000447-1	2017	We previously demonstrated that curcumin reduces cholesterol absorption in Caco-2 cells through down-regulating Niemann-Pick C1-like 1 (NPC1L1) expression, but the in vivo effect of curcumin on intestinal cholesterol absorption remains unknown.	Curcumin	32-40	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	136-142
28000447-6	2017	Moreover, curcumin supplementation down-regulated the mRNA and protein expressions of sterol regulatory element binding protein-2 (SREBP-2) and NPC1L1 in the small intestine (P &lt; 0.05).	Curcumin	10-18	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	144-150
28000447-7	2017	Our current results indicate that curcumin inhibits cholesterol absorption in hamsters by suppressing SREBP-2 and subsequently down-regulating NPC1L1 expression, which may be responsible for the hypocholesterolemic effects of curcumin.	Curcumin	34-42	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	143-149
28077837-0	2017	Curcumin Inhibits Gastric Carcinoma Cell Growth and Induces Apoptosis by Suppressing the Wnt/beta-Catenin Signaling Pathway.	Curcumin	0-8	catenin beta 1	Homo sapiens	93-105
28077837-2	2017	The Wnt/beta-catenin signaling pathway plays a central role in tumor cell proliferation and curcumin can regulate the Wnt/b-catenin signaling pathway of several carcinomas.	Curcumin	92-100	catenin beta 1	Homo sapiens	8-20
28077837-3	2017	The aim of this study was to investigate the impact of curcumin on the Wnt/beta-catenin signaling pathway in human gastric cancer cells.	Curcumin	55-63	catenin beta 1	Homo sapiens	75-87
28077837-7	2017	Curcumin significantly suppressed the levels of Wnt3a, LRP6, phospho-LRP6, beta-catenin, phospho-beta-catenin, C-myc, and survivin.	Curcumin	0-8	catenin beta 1	Homo sapiens	75-87
28077837-7	2017	Curcumin significantly suppressed the levels of Wnt3a, LRP6, phospho-LRP6, beta-catenin, phospho-beta-catenin, C-myc, and survivin.	Curcumin	0-8	catenin beta 1	Homo sapiens	97-109
28077837-7	2017	Curcumin significantly suppressed the levels of Wnt3a, LRP6, phospho-LRP6, beta-catenin, phospho-beta-catenin, C-myc, and survivin.	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	111-116
28077837-8	2017	Xenograft growth in vivo was inhibited and the target genes of Wnt/beta-catenin signaling were also reduced by curcumin treatment.	Curcumin	111-119	catenin beta 1	Homo sapiens	67-79
28077837-10	2017	Inhibition of the Wnt/beta-catenin signaling pathway and the subsequently reduced expression of Wnt target genes show potential as a newly-identified molecular mechanism of curcumin treatment.	Curcumin	173-181	catenin beta 1	Homo sapiens	22-34
28678631-13	2017	Curcumin, a specific inhibitor of JNK, can prevent the development of hypertensive retinopathy after I/R injury by inhibiting apoptosis in retinal capillary cells and neurons.	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	34-37
34335911-8	2021	Curcumin enhanced miR-30a-5p expression and inhibited PCLAF expression; furthermore, there was a negative correlation between miR-30a-5p and PCLAF expression in PCa tissues.	Curcumin	0-8	microRNA 30a	Homo sapiens	18-25
28228072-7	2017	Specifically, curcumin"s anti-inflammatory effects are thought to be caused by reducing trans-endothelial monocyte migration by reduction of mRNA and protein expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and P-selectin and by modulating NFkappaB, JNK, p38 and STAT-3 in endothelial cells.	Curcumin	14-22	selectin P	Homo sapiens	245-255
28270067-1	2017	OBJECTIVE: The aim of the study wasto fabricate curcumin-loaded PLGA-PEG-Fe3O4 nanoparticles and comprise the effects of pure curcumin and curcumin-nanomagnetic encapsulated in PLGA-PEG on cell cytotoxicity and hTERT gene expression in A549 lung cancer cell line.	Curcumin	48-56	telomerase reverse transcriptase	Homo sapiens	211-216
34335911-8	2021	Curcumin enhanced miR-30a-5p expression and inhibited PCLAF expression; furthermore, there was a negative correlation between miR-30a-5p and PCLAF expression in PCa tissues.	Curcumin	0-8	microRNA 30a	Homo sapiens	126-133
28270067-15	2017	In addition, the expression level of the hTERT was reduced with increasing concentrations in both pure and nano-encapsulated curcumin.	Curcumin	125-133	telomerase reverse transcriptase	Homo sapiens	41-46
28228072-8	2017	Dietary curcumin supplementation can also increase antioxidant activity through the induction of heme oxygenase-1, a scavenger of free radicals, and by reduction of reactive oxygen species and Nox-2.	Curcumin	8-16	heme oxygenase 1	Homo sapiens	97-113
28412905-10	2017	The regulation of HO-1/CO expression has been achieved either by genetic overexpression of HO-1 cDNA or pharmacological induction with drugs including curcumin and resveratrol.	Curcumin	151-159	heme oxygenase 1	Homo sapiens	18-25
34335911-9	2021	In addition, transfection of miR-30a-5p inhibitors partially reversed the function of curcumin on cell proliferation, migration, invasion and apoptosis.	Curcumin	86-94	microRNA 30a	Homo sapiens	29-36
28412905-10	2017	The regulation of HO-1/CO expression has been achieved either by genetic overexpression of HO-1 cDNA or pharmacological induction with drugs including curcumin and resveratrol.	Curcumin	151-159	heme oxygenase 1	Homo sapiens	18-22
34335911-10	2021	Overall, curcumin suppressed the malignant biological behaviors of PCa cells by regulating the miR-30a-5p/PCLAF axis.	Curcumin	9-17	microRNA 30a	Homo sapiens	95-102
28203261-4	2017	Here we found that curcumin pretreatment significantly represses TGF-beta1-induced Smad pathway and decreases its downstream alpha-smooth muscle actin (alpha-SMA) gene expression in intestinal epithelial cells (IEC-6); in contrast, curcumin increases expression of E-cadherin and peroxisome proliferator-activated receptor gamma (PPARgamma) in IEC-6.	Curcumin	19-27	actin gamma 2, smooth muscle	Rattus norvegicus	125-150
28203261-4	2017	Here we found that curcumin pretreatment significantly represses TGF-beta1-induced Smad pathway and decreases its downstream alpha-smooth muscle actin (alpha-SMA) gene expression in intestinal epithelial cells (IEC-6); in contrast, curcumin increases expression of E-cadherin and peroxisome proliferator-activated receptor gamma (PPARgamma) in IEC-6.	Curcumin	19-27	actin gamma 2, smooth muscle	Rattus norvegicus	152-161
28203261-4	2017	Here we found that curcumin pretreatment significantly represses TGF-beta1-induced Smad pathway and decreases its downstream alpha-smooth muscle actin (alpha-SMA) gene expression in intestinal epithelial cells (IEC-6); in contrast, curcumin increases expression of E-cadherin and peroxisome proliferator-activated receptor gamma (PPARgamma) in IEC-6.	Curcumin	19-27	cadherin 1	Rattus norvegicus	265-275
28340987-0	2017	Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents.	Curcumin	19-27	solute carrier family 22 (organic anion/cation transporter), member 12	Mus musculus	71-90
28340987-1	2017	A series of curcumin derivatives as potent dual inhibitors of xanthine oxidase (XOD) and urate transporter 1 (URAT1) was discovered as anti-hyperuricemic agents.	Curcumin	12-20	solute carrier family 22 (organic anion/cation transporter), member 12	Mus musculus	89-108
28340987-1	2017	A series of curcumin derivatives as potent dual inhibitors of xanthine oxidase (XOD) and urate transporter 1 (URAT1) was discovered as anti-hyperuricemic agents.	Curcumin	12-20	solute carrier family 22 (organic anion/cation transporter), member 12	Mus musculus	110-115
29069652-0	2017	Protective Effect of Curcumin Against Oxidative Stress-Induced Injury in Rats with Parkinson"s Disease Through the Wnt/ beta-Catenin Signaling Pathway.	Curcumin	21-29	catenin beta 1	Rattus norvegicus	120-132
34671007-3	2021	Our previous transcriptome study revealed that ANXA8 mRNA was downregulated in curcumin analog (MHMD) -treated human non-small lung cancer cells (A549 cell line).	Curcumin	79-87	annexin A8	Homo sapiens	47-52
29069652-1	2017	BACKGROUND/AIMS: The study aimed to investigate the protective effect of curcumin against oxidative stress-induced injury of Parkinson"s disease (PD) through the Wnt/beta-catenin signaling pathway in rats.	Curcumin	73-81	catenin beta 1	Rattus norvegicus	166-178
29069652-8	2017	Curcumin enhanced viability, survival and adhesion and attenuated apoptosis of deutocerebrum primary cells by activating the Wnt/beta-catenin signaling pathway.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	129-141
29949292-6	2017	AMH levels were significantly higher in the curcumin subgroup compared to sham and control within group 2 and in group 2 versus group 1 curcumin subgroups.	Curcumin	44-52	anti-Mullerian hormone	Rattus norvegicus	0-3
29949292-6	2017	AMH levels were significantly higher in the curcumin subgroup compared to sham and control within group 2 and in group 2 versus group 1 curcumin subgroups.	Curcumin	136-144	anti-Mullerian hormone	Rattus norvegicus	0-3
28203261-4	2017	Here we found that curcumin pretreatment significantly represses TGF-beta1-induced Smad pathway and decreases its downstream alpha-smooth muscle actin (alpha-SMA) gene expression in intestinal epithelial cells (IEC-6); in contrast, curcumin increases expression of E-cadherin and peroxisome proliferator-activated receptor gamma (PPARgamma) in IEC-6.	Curcumin	232-240	actin gamma 2, smooth muscle	Rattus norvegicus	152-161
28203261-6	2017	Consistently, in the rat model of intestinal fibrosis induced by 2,4,5-trinitrobenzene sulphonic acid (TNBS), oral curcumin attenuates intestinal fibrosis by increasing the expression of PPARgamma and E-cadherin and decreasing the expression of alpha-SMA, FN, and CTGF in colon tissue.	Curcumin	115-123	cadherin 1	Rattus norvegicus	201-211
28203261-6	2017	Consistently, in the rat model of intestinal fibrosis induced by 2,4,5-trinitrobenzene sulphonic acid (TNBS), oral curcumin attenuates intestinal fibrosis by increasing the expression of PPARgamma and E-cadherin and decreasing the expression of alpha-SMA, FN, and CTGF in colon tissue.	Curcumin	115-123	actin gamma 2, smooth muscle	Rattus norvegicus	245-254
28203261-6	2017	Consistently, in the rat model of intestinal fibrosis induced by 2,4,5-trinitrobenzene sulphonic acid (TNBS), oral curcumin attenuates intestinal fibrosis by increasing the expression of PPARgamma and E-cadherin and decreasing the expression of alpha-SMA, FN, and CTGF in colon tissue.	Curcumin	115-123	cellular communication network factor 2	Rattus norvegicus	264-268
28769986-0	2017	Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway.	Curcumin	0-8	phosphatase and tensin homolog	Homo sapiens	77-81
28769986-0	2017	Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway.	Curcumin	0-8	forkhead box O4	Homo sapiens	82-87
34471643-0	2021	Curcumin Alleviates Palmitic Acid-Induced LOX-1 Upregulation by Suppressing Endoplasmic Reticulum Stress in HUVECs.	Curcumin	0-8	oxidized low density lipoprotein receptor 1	Homo sapiens	42-47
28769986-5	2017	Subcellular fractionations revealed that the FOXO4 protein translocated from cytosol into the nucleus after curcumin treatment.	Curcumin	108-116	forkhead box O4	Homo sapiens	45-50
28769986-6	2017	Overexpression of FOXO4 increases the sensitivity of Hep3B cells to curcumin.	Curcumin	68-76	forkhead box O4	Homo sapiens	18-23
28769986-7	2017	Knockdown of the FOXO4 gene by siRNA inhibits the proapoptotic effects of curcumin on Hep3B cell.	Curcumin	74-82	forkhead box O4	Homo sapiens	17-22
28067164-7	2017	Recent studies have documented that pharmacological effects of curcumin in lung cancer are also mediated by modulation of several miRNAs, such as downregulation of oncogenic miR-21 and upregulation of oncosuppressive miR-192-5p and miR-215.	Curcumin	63-71	microRNA 21	Homo sapiens	174-180
28244571-9	2017	Curcumin treatment is significantly reduced MPO activity, and inflammatory cell accumulation in the BALF and also protein level, MDA, SOD, and W/D ratio were significantly reduced in the lung tissues.	Curcumin	0-8	myeloperoxidase	Rattus norvegicus	44-47
34471643-4	2021	Curcumin reduces the LOX-1 expression; however, the mechanism underlying this effect remains unknown.	Curcumin	0-8	oxidized low density lipoprotein receptor 1	Homo sapiens	21-26
27979493-6	2017	Furthermore, curcumin decreased Evans blue extravasation, matrix metallopeptidase-9 expression, and the number of Iba-1-positive microglia in treated mice compared with SAH mice.	Curcumin	13-21	induction of brown adipocytes 1	Mus musculus	114-119
34471643-5	2021	In the current study, we explored whether curcumin ameliorates palmitic acid- (PA-) induced endothelial lipotoxicity and LOX-1 upregulation by reducing ER stress in human umbilical vein endothelial cells (HUVECs).	Curcumin	42-50	oxidized low density lipoprotein receptor 1	Homo sapiens	121-126
34471643-8	2021	Furthermore, LOX-1 upregulation in HUVECs was blocked by curcumin, possibly via ER stress suppression.	Curcumin	57-65	oxidized low density lipoprotein receptor 1	Homo sapiens	13-18
27863439-6	2016	In this study, we confirm that the high invasive EOC cells forming the spheroids express a high level of a cancer stem cell (CSC) marker, aldehyde dehydrogenase 1 family member A1 (ALDH1A1), which was significantly down-regulated by curcumin treatment.	Curcumin	233-241	aldehyde dehydrogenase 1 family member A1	Homo sapiens	138-179
27863439-6	2016	In this study, we confirm that the high invasive EOC cells forming the spheroids express a high level of a cancer stem cell (CSC) marker, aldehyde dehydrogenase 1 family member A1 (ALDH1A1), which was significantly down-regulated by curcumin treatment.	Curcumin	233-241	aldehyde dehydrogenase 1 family member A1	Homo sapiens	181-188
27863439-9	2016	Moreover, curcumin substantially suppressed the growth of the pre-existed EOC spheroids, inhibited the adhesion of EOC spheroids to ECM as well as the invasion of EOC spheroids to the mesothelial monolayers.	Curcumin	10-18	multimerin 1	Homo sapiens	132-135
29158871-4	2017	Starting from curcumin and caffeic acid phenethyl ester (CAPE), two known HO-1 inducers, the molecules were chemically modified by acylation with 4-bromo-butanoyl chloride and 2-chloro-propanoyl chloride, respectively, and then treated in the dark with AgNO3 to obtain the nitrate derivatives VP10/12 and VP10/39.	Curcumin	14-22	heme oxygenase 1	Homo sapiens	74-78
34462629-4	2021	Importantly, the results of qPCR and immunochemistry showed that curcumin decreased M1 (iNOS, CCL2, and CD86) but increased M2 macrophage (Arg1, CD163, and CD206) marker expression in the myocardium of MI mice during the first 7 days post-MI.	Curcumin	65-73	arginase, liver	Mus musculus	139-143
27888616-9	2016	Finally, we reported that curcumin, a powerful natural drug, suppressed the production of EGF and CCL2 in macrophages and cancer cells, respectively, blocking the feedback loop and suppressing the migration and invasion of HNSCC cells.	Curcumin	26-34	epidermal growth factor	Homo sapiens	90-93
34462629-5	2021	And flow cytometry analysis indicated that curcumin suppressed M1 (CD45+Gr-1-CD11b+iNOS+ cells) but enhanced M2 macrophage (CD45+Gr-1-CD11b+Arg+ cells) expansion in the myocardium of MI mice during the first 7 days post-MI.	Curcumin	43-51	glutathione reductase	Mus musculus	72-76
27888616-9	2016	Finally, we reported that curcumin, a powerful natural drug, suppressed the production of EGF and CCL2 in macrophages and cancer cells, respectively, blocking the feedback loop and suppressing the migration and invasion of HNSCC cells.	Curcumin	26-34	C-C motif chemokine ligand 2	Homo sapiens	98-102
34462629-5	2021	And flow cytometry analysis indicated that curcumin suppressed M1 (CD45+Gr-1-CD11b+iNOS+ cells) but enhanced M2 macrophage (CD45+Gr-1-CD11b+Arg+ cells) expansion in the myocardium of MI mice during the first 7 days post-MI.	Curcumin	43-51	glutathione reductase	Mus musculus	129-133
34174576-2	2021	Our previous studies about comparative transcriptome have shown that curcumin can enhance the Nrf2-Keap1 signaling pathway and induce downstream anti-stress genes to maintain cell viability.	Curcumin	69-77	kelch-like ECH-associated protein 1	Oreochromis niloticus	99-104
29292884-6	2016	Compared with OA group, p-JAK2, p-STAT3 protein expression was increased in curcumin with OA, Bax protein expression was decreased (P&lt;0.05), SDA and COX protein expression were increased (P&lt;0.05), and had statistical differences among three groups.	Curcumin	76-84	BCL2 associated X, apoptosis regulator	Rattus norvegicus	94-97
29292884-7	2016	CONCLUSIONS: JAK2/STAT3 signal pathway is closely associated with pathology course of osteoarthritis, curcumin could stimulate JAK2/STAT3 signal pathway and promote mitochondria oxidative stress.	Curcumin	102-110	signal transducer and activator of transcription 3	Rattus norvegicus	18-23
27866850-5	2016	Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy.	Curcumin	22-30	CD274 molecule	Homo sapiens	54-59
27866850-5	2016	Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy.	Curcumin	22-30	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	107-112
29292884-7	2016	CONCLUSIONS: JAK2/STAT3 signal pathway is closely associated with pathology course of osteoarthritis, curcumin could stimulate JAK2/STAT3 signal pathway and promote mitochondria oxidative stress.	Curcumin	102-110	signal transducer and activator of transcription 3	Rattus norvegicus	132-137
34174576-12	2021	miR-153b, miR-200a, and miR-29 may be involved in the regulation of the Nrf2-Keap1 signaling pathway by curcumin.	Curcumin	104-112	kelch-like ECH-associated protein 1	Oreochromis niloticus	77-82
27625050-7	2016	RESULTS: MiR-1275 and miR-1246 expression levels were up-regulated by curcumin.	Curcumin	70-78	microRNA 1246	Homo sapiens	22-30
34194553-7	2021	Curcumin significantly inhibited cell viability, migration and invasion and downregulated MMP-2, MMP-9 and EMT marker expression.	Curcumin	0-8	matrix metallopeptidase 2	Homo sapiens	90-95
27625050-10	2016	Furthermore, overexpression of NKAP interrupted effects of curcumin on the cells.	Curcumin	59-67	NFKB activating protein	Homo sapiens	31-35
27625050-11	2016	CONCLUSION: Collectively, our findings demonstrate that curcumin inhibited HUVEC proliferation by up-regulation of miR-1275 and miR-1246.	Curcumin	56-64	microRNA 1246	Homo sapiens	128-136
34194553-8	2021	Additionally, curcumin decreased STAT3 expression by upregulating miR-301a-3p expression, and the inhibition of miR-301a-3p and the overexpression of STAT3 reversed the effects of curcumin on cell viability, migration and invasion, and MMP-2, MMP-9 and EMT marker expression in TPC-1 cells.	Curcumin	14-22	matrix metallopeptidase 2	Homo sapiens	236-241
28105222-10	2016	Furthermore, while curcumin induced cell apoptosis and enhanced the expression ratio of Bax/Bcl-2, which are downstream molecules of p53, ectopic expression of H19 inhibited curcumin-induced cell apoptosis.	Curcumin	19-27	H19 imprinted maternally expressed transcript	Homo sapiens	160-163
27875331-4	2016	Curcumin loaded within amine functionalized MSN (MSN-A-Cur) had a better release profile and a higher solubility compared to amine MSM (MSM-A-Cur).	Curcumin	0-8	moesin	Mus musculus	44-47
27875331-4	2016	Curcumin loaded within amine functionalized MSN (MSN-A-Cur) had a better release profile and a higher solubility compared to amine MSM (MSM-A-Cur).	Curcumin	0-8	moesin	Mus musculus	49-58
28105222-10	2016	Furthermore, while curcumin induced cell apoptosis and enhanced the expression ratio of Bax/Bcl-2, which are downstream molecules of p53, ectopic expression of H19 inhibited curcumin-induced cell apoptosis.	Curcumin	174-182	H19 imprinted maternally expressed transcript	Homo sapiens	160-163
28105222-11	2016	In addition, curcumin decreased the expression of the c-Myc oncogene, and exogenous c-Myc protein reversed the curcumin-induced downregulation of H19 expression.	Curcumin	13-21	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	54-59
27657825-13	2016	Additionally, Caspase-3 and Caspase-9 were activated by curcumin.	Curcumin	56-64	caspase 9	Homo sapiens	28-37
34169637-4	2021	Further research found that the effects of NE on glioma cells could lead to the activation of the mitogen-activated protein kinase (MAPK) signalling pathway through beta-adrenergic receptor, while curcumin suppressed the level of extracellular signal-regulated kinase (ERK)1/2 phosphorylation.	Curcumin	197-205	mitogen-activated protein kinase 3	Mus musculus	230-276
28105222-11	2016	In addition, curcumin decreased the expression of the c-Myc oncogene, and exogenous c-Myc protein reversed the curcumin-induced downregulation of H19 expression.	Curcumin	111-119	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	84-89
28105222-11	2016	In addition, curcumin decreased the expression of the c-Myc oncogene, and exogenous c-Myc protein reversed the curcumin-induced downregulation of H19 expression.	Curcumin	111-119	H19 imprinted maternally expressed transcript	Homo sapiens	146-149
34169637-6	2021	Curcumin could also inhibit the expression of cyclin D1/CDK4/6 and anti-apoptotic protein Bcl-2/Bcl-XL induced by NE, and induced cell cycle changes and increased apoptosis.	Curcumin	0-8	BCL2-like 1	Mus musculus	96-102
28105222-12	2016	These results suggested that curcumin inhibits the proliferation of gastric cancer cells by downregulating the c-Myc/H19 pathway.	Curcumin	29-37	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	111-116
28105222-12	2016	These results suggested that curcumin inhibits the proliferation of gastric cancer cells by downregulating the c-Myc/H19 pathway.	Curcumin	29-37	H19 imprinted maternally expressed transcript	Homo sapiens	117-120
27626325-12	2016	Nanocurcumin supplementation decreased HH-induced RVH and apoptosis while modulating cardiac cGMP/cGK-1 signaling, and maintaining CaMkinase II, intracellular calcium levels and redox status better than curcumin.	Curcumin	4-12	protein kinase cGMP-dependent 1	Rattus norvegicus	98-103
27466310-7	2016	After the administration of curcumin for 6 months, the results showed that the expression of an insulin receptor (InR) and insulin receptor substrate (IRS)-1 decreased in the hippocampal CA1 area of the APPswe/PS1dE9 double transgenic mice, while the expression of phosphatidylinositol-3 kinase (PI3K), phosphorylated PI3K (p-PI3K), serine-threonine kinase (AKT) and phosphorylated AKT (p-AKT) increased.	Curcumin	28-36	insulin receptor substrate 1	Mus musculus	123-157
27466310-7	2016	After the administration of curcumin for 6 months, the results showed that the expression of an insulin receptor (InR) and insulin receptor substrate (IRS)-1 decreased in the hippocampal CA1 area of the APPswe/PS1dE9 double transgenic mice, while the expression of phosphatidylinositol-3 kinase (PI3K), phosphorylated PI3K (p-PI3K), serine-threonine kinase (AKT) and phosphorylated AKT (p-AKT) increased.	Curcumin	28-36	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	265-294
34096956-0	2021	Gut microbiota mediates the effects of curcumin on enhancing Ucp1-dependent thermogenesis and improving high-fat diet-induced obesity.	Curcumin	39-47	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	61-65
27840063-6	2016	Notably, both oxidative stress and the inhibition of Wnt/beta-catenin signaling are attenuated by curcumin treatment.	Curcumin	98-106	catenin beta 1	Homo sapiens	57-69
27831561-9	2016	Finally, RNAseq analysis indicated that p53 signaling in Lgr5+ stem cells from mice exposed to AOM was uniquely upregulated only following n-3 PUFA+curcumin cotreatment.	Curcumin	148-156	transformation related protein 53, pseudogene	Mus musculus	40-43
27877129-10	2016	Furthermore, curcumin and rosiglitazone upregulated PPAR-gamma and downregulated PDGFR-beta expression in mouse lung fibroblasts.	Curcumin	13-21	platelet derived growth factor receptor, beta polypeptide	Mus musculus	81-91
34096956-6	2021	The anti-obesity effects of curcumin were abolished by Ucp1 knockout.	Curcumin	28-36	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	55-59
34096956-8	2021	Fecal microbiota transplantation (FMT) and endogenous GM depletion indicated that the GM mediated the enhanced effect of curcumin on Ucp1-dependent thermogenesis.	Curcumin	121-129	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	133-137
27763524-8	2016	Moreover, 2 h incubation with curcumin powder, solid dispersion formulation, and its physical mixture resulted in differential cytotoxic effect of paclitaxel in P-gp overexpressed LLC-PK1-P-gp and MDA-MB-231 cells through the inhibition of P-gp-mediated paclitaxel efflux.	Curcumin	30-38	phosphoglycolate phosphatase	Homo sapiens	161-165
34096956-10	2021	Consistently, the enhanced effect of curcumin on Ucp1-dependent thermogenesis was eliminated by TGR5 knockout.	Curcumin	37-45	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	49-53
27763524-8	2016	Moreover, 2 h incubation with curcumin powder, solid dispersion formulation, and its physical mixture resulted in differential cytotoxic effect of paclitaxel in P-gp overexpressed LLC-PK1-P-gp and MDA-MB-231 cells through the inhibition of P-gp-mediated paclitaxel efflux.	Curcumin	30-38	phosphoglycolate phosphatase	Homo sapiens	188-192
27452394-2	2016	The current study examines effect of curcumin on: 1) systemic T helper 17 (Th17) cell response; 2) gingival expressions of interleukin (IL)-17 and retinoic acid receptor-related orphan receptor (ROR) gammat; and 3) alveolar bone loss (ABL) in experimental periodontitis.	Curcumin	37-45	interleukin 17A	Rattus norvegicus	123-142
27452394-11	2016	CONCLUSION: Curcumin seems to be a promising host modulatory agent in periodontal disease pathogenesis regarding IL-17/IL-23 axis, with a decreasing effect on ABL and gingival expressions of IL-17 and RORgammat.	Curcumin	12-20	interleukin 17A	Rattus norvegicus	113-118
27452394-11	2016	CONCLUSION: Curcumin seems to be a promising host modulatory agent in periodontal disease pathogenesis regarding IL-17/IL-23 axis, with a decreasing effect on ABL and gingival expressions of IL-17 and RORgammat.	Curcumin	12-20	interleukin 17A	Rattus norvegicus	191-196
27763524-8	2016	Moreover, 2 h incubation with curcumin powder, solid dispersion formulation, and its physical mixture resulted in differential cytotoxic effect of paclitaxel in P-gp overexpressed LLC-PK1-P-gp and MDA-MB-231 cells through the inhibition of P-gp-mediated paclitaxel efflux.	Curcumin	30-38	phosphoglycolate phosphatase	Homo sapiens	188-192
34096956-12	2021	Here, we demonstrated that the GM mediates the effects of curcumin on enhancing Ucp1-dependent thermogenesis and ameliorating HFD-induced obesity by influencing BA metabolism.	Curcumin	58-66	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	80-84
27280688-5	2016	At the molecular and cellular level, curcumin can blunt epithelial-to-mesenchymal transition and affect many targets that are involved in melanoma initiation and progression (e.g., BCl2, MAPKS, p21 and some microRNAs).	Curcumin	37-45	H3 histone pseudogene 16	Homo sapiens	194-197
27626169-2	2016	The COP9 signalosome (CSN) component CSN5, a known specific target for curcumin, can control p53 stability by increasing its degradation through ubiquitin system.	Curcumin	71-79	COP9 signalosome subunit 8	Homo sapiens	4-8
27404761-4	2016	The cytotoxicity assay was performed for human colon and prostate cancer (SW480 and LNCap) by MTT assay and results showed significantly higher cytotoxicity of nanoencapsulated curcumin (NEC) (equivalent to 30.91, 20.70 and 16.86microM of NEC-1, 2 and 3 respectively), as compared to plain curcumin at 50microM after 72h of treatment.	Curcumin	177-185	proprotein convertase subtilisin/kexin type 1	Homo sapiens	239-253
27404761-6	2016	The cells treated with 50microM of curcumin, 30.91microM (NEC-1), 20.70microM (NEC-2) and 16.86microM (NEC-3) showed enhanced activation of p53 and elevated bax/Bcl2 expression (NEC-3), increased cytochrome-c in cytosol (NEC-2) confirming the enhanced cytotoxicity.	Curcumin	35-43	proprotein convertase subtilisin/kexin type 1	Homo sapiens	58-63
27404761-6	2016	The cells treated with 50microM of curcumin, 30.91microM (NEC-1), 20.70microM (NEC-2) and 16.86microM (NEC-3) showed enhanced activation of p53 and elevated bax/Bcl2 expression (NEC-3), increased cytochrome-c in cytosol (NEC-2) confirming the enhanced cytotoxicity.	Curcumin	35-43	proprotein convertase subtilisin/kexin type 2	Homo sapiens	79-84
27777559-0	2016	Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-kappaB and P2X7R Signaling in PMA-Induced Macrophages.	Curcumin	0-8	toll like receptor 4	Homo sapiens	53-57
34565029-7	2021	In addition, curcumin treatment downregulated p-JAK2 and p-STAT3 in TPC-1 and SW1736 cells.	Curcumin	13-21	Janus kinase 2	Homo sapiens	48-52
27393927-6	2016	Thus, curcumin treatment attenuates LPS-induced PI3K/AKT and CYP2E/Nrf2/ROS signaling and liver injury.	Curcumin	6-14	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	61-66
27600729-8	2016	In addition, curcumin treatment reduced apoptosis in the testis, and decreased expression of Fas, Bax and cleaved-caspase 3, as well as increased expression of Bcl-xl.	Curcumin	13-21	BCL2 associated X, apoptosis regulator	Rattus norvegicus	98-101
27297718-1	2016	OBJECTIVE: Previous experimental studies have suggested curcumin as a safe phytochemical that can improve insulin resistance through effects on adiponectin and leptin.	Curcumin	56-64	leptin	Homo sapiens	160-166
27297718-2	2016	This study aimed to investigate the effect of curcumin on circulating adiponectin and leptin concentrations in patients with metabolic syndrome.	Curcumin	46-54	leptin	Homo sapiens	86-92
27404761-6	2016	The cells treated with 50microM of curcumin, 30.91microM (NEC-1), 20.70microM (NEC-2) and 16.86microM (NEC-3) showed enhanced activation of p53 and elevated bax/Bcl2 expression (NEC-3), increased cytochrome-c in cytosol (NEC-2) confirming the enhanced cytotoxicity.	Curcumin	35-43	proprotein convertase subtilisin/kexin type 2	Homo sapiens	221-226
27404761-8	2016	The fluorescent signal for intracellular curcumin was increased by 12, 30, and 21% for NEC-1, NEC-2, and NEC-3 respectively as compared to plain curcumin at 4h.	Curcumin	41-49	proprotein convertase subtilisin/kexin type 1	Homo sapiens	87-92
27404761-8	2016	The fluorescent signal for intracellular curcumin was increased by 12, 30, and 21% for NEC-1, NEC-2, and NEC-3 respectively as compared to plain curcumin at 4h.	Curcumin	41-49	proprotein convertase subtilisin/kexin type 2	Homo sapiens	94-99
27297718-5	2016	The pooled effect size for the impact of curcumin supplementation on serum adiponectin and leptin levels was also estimated using random-effects metaanalysis.	Curcumin	41-49	leptin	Homo sapiens	91-97
27297718-6	2016	RESULTS: Eight-week supplementation with curcumin was associated with a significant increase in serum adiponectin levels (P &lt; 0.001) and a reduction in serum leptin concentrations (P &lt; 0.001).	Curcumin	41-49	leptin	Homo sapiens	161-167
34565029-8	2021	CONCLUSIONS: Curcumin treatment blocks PTC cells to proliferate and invade via inhibiting the JAK2/STAT3 pathway.	Curcumin	13-21	Janus kinase 2	Homo sapiens	94-98
27297718-7	2016	Serum leptin:adiponectin ratio was also improved by curcumin (P &lt; 0.001).	Curcumin	52-60	leptin	Homo sapiens	6-12
34192476-10	2021	We have checked MYC-expression at transcriptional and translational level and proceeded for Chromatin Immuno-Precipitation assay (ChIP) to study the occupancy level of SP1, Heterogeneous nuclear ribonucleoprotein K (hnRNPK), Nucleoside Diphosphate Kinase 2 (NM23-H2) and Nucleolin at NHEIII1 upon Curcumin treatment of MDA-MB-231 cells.	Curcumin	297-305	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	216-222
27564099-9	2016	Moreover, pretreatment with U0126 suppressed curcumin and cisplatin-induced upregulation of p53, p21, and p-STAT3 and downregulation of survival proteins in both cells.	Curcumin	45-53	H3 histone pseudogene 16	Homo sapiens	97-100
27375190-0	2016	Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation of Nrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	103-107
34192476-10	2021	We have checked MYC-expression at transcriptional and translational level and proceeded for Chromatin Immuno-Precipitation assay (ChIP) to study the occupancy level of SP1, Heterogeneous nuclear ribonucleoprotein K (hnRNPK), Nucleoside Diphosphate Kinase 2 (NM23-H2) and Nucleolin at NHEIII1 upon Curcumin treatment of MDA-MB-231 cells.	Curcumin	297-305	nucleolin	Homo sapiens	271-280
27375190-5	2016	In addition, curcumin pretreatment markedly attenuated QCT-induced increase of iNOS activity and NO production in a dose-dependent manner.	Curcumin	13-21	inositol-3-phosphate synthase 1	Homo sapiens	79-83
27746842-7	2016	Conclusion Curcumin proved to be potentially effective in the prevention and treatment for fibroblasts damage within the cochlear supporting tissues and lateral wall regarding the decreased expression of calcineurin, NFATc1, and apoptotic index of cochlear fibroblasts.	Curcumin	11-19	nuclear factor of activated T-cells 1	Rattus norvegicus	217-223
27456358-0	2016	Curcumin inhibits cell growth and induces cell apoptosis through upregulation of miR-33b in gastric cancer.	Curcumin	0-8	microRNA 33b	Homo sapiens	81-88
27375190-6	2016	Meanwhile, curcumin pretreatment markedly down-regulated the expression of nuclear factor -kB (NF-kB) and iNOS mRNAs, but up-regulated the expressions of Nrf2 and HO-1 mRNAs, compared to the QCT alone group.	Curcumin	11-19	inositol-3-phosphate synthase 1	Homo sapiens	106-110
34234410-9	2021	Results: A total of 16 target genes of curcumin and GBM were obtained, among which ENO1, MMP2, and PRKD2 significantly affected the prognosis (P < 0.05).	Curcumin	39-47	matrix metallopeptidase 2	Homo sapiens	89-93
27375190-6	2016	Meanwhile, curcumin pretreatment markedly down-regulated the expression of nuclear factor -kB (NF-kB) and iNOS mRNAs, but up-regulated the expressions of Nrf2 and HO-1 mRNAs, compared to the QCT alone group.	Curcumin	11-19	heme oxygenase 1	Homo sapiens	163-167
27375190-7	2016	Zinc protoporphyrin IX, a HO-1 inhibitor, markedly partly abolished the cytoprotective effect of curcumin against QCT-induced caspase activation, NF-kB mRNA expression.	Curcumin	97-105	heme oxygenase 1	Homo sapiens	26-30
27432244-5	2016	Curcumin induced G1 phase arrest through downregulating the expression of cyclin D3 and cyclin-dependent kinase (CDK)2/6 and upregulating the expression of CDK inhibitor proteins p21 and p27.	Curcumin	0-8	H3 histone pseudogene 16	Homo sapiens	179-182
27432244-5	2016	Curcumin induced G1 phase arrest through downregulating the expression of cyclin D3 and cyclin-dependent kinase (CDK)2/6 and upregulating the expression of CDK inhibitor proteins p21 and p27.	Curcumin	0-8	interferon alpha inducible protein 27	Homo sapiens	187-190
27456358-4	2016	The first stage of our studies showed that curcumin affected the expression of miR-33b, which, in turn, affected the expression of the X-linked inhibitor of apoptosis protein (XIAP) messenger RNA (mRNA).	Curcumin	43-51	microRNA 33b	Homo sapiens	79-86
27456358-8	2016	The results showed that curcumin had similar effects on cell growth and apoptosis as the upregulation of miR-33b and the upregulation of the siRNA of XIAP.	Curcumin	24-32	microRNA 33b	Homo sapiens	105-112
27456358-10	2016	Collectively, our results indicate that curcumin-miR-33b-XIAP coupling might be an important mechanism by which curcumin induces the apoptosis of SGC-7901 and BGC-823 cells.	Curcumin	40-48	microRNA 33b	Homo sapiens	49-56
27456358-10	2016	Collectively, our results indicate that curcumin-miR-33b-XIAP coupling might be an important mechanism by which curcumin induces the apoptosis of SGC-7901 and BGC-823 cells.	Curcumin	112-120	microRNA 33b	Homo sapiens	49-56
34234410-9	2021	Results: A total of 16 target genes of curcumin and GBM were obtained, among which ENO1, MMP2, and PRKD2 significantly affected the prognosis (P < 0.05).	Curcumin	39-47	protein kinase D2	Homo sapiens	99-104
27710431-4	2016	150 mg/kg curcumin treatment alone significantly reduced levels of serum ALT and LDH that were induced by UDMH and markedly increased level of gamma-amino butyric acid (GABA) that were reduced by UDMH in the hippocampus.	Curcumin	10-18	glutamic pyruvic transaminase, soluble	Mus musculus	73-76
34248973-5	2021	The curcumin analog and antitumor agent, GO-Y030, prevented the TGF-beta-induced generation of Tregs by preventing p300 from accelerating NF-kappaB-induced Foxp3 expression.	Curcumin	4-12	transforming growth factor alpha	Homo sapiens	64-72
27431486-2	2016	In the present study, we screened a double carbonyl analog of curcumin (A17) and analyzed its effects and mechanism of inducing apoptosis in human lung cancer H460 cells.	Curcumin	62-70	immunoglobulin kappa variable 2-30	Homo sapiens	72-75
34248973-5	2021	The curcumin analog and antitumor agent, GO-Y030, prevented the TGF-beta-induced generation of Tregs by preventing p300 from accelerating NF-kappaB-induced Foxp3 expression.	Curcumin	4-12	E1A binding protein p300	Homo sapiens	115-119
34248973-5	2021	The curcumin analog and antitumor agent, GO-Y030, prevented the TGF-beta-induced generation of Tregs by preventing p300 from accelerating NF-kappaB-induced Foxp3 expression.	Curcumin	4-12	forkhead box P3	Homo sapiens	156-161
27585262-0	2016	A comparison between PLGA-PEG and NIPAAm-MAA nanocarriers in curcumin delivery for hTERT silencing in lung cancer cell line.	Curcumin	61-69	telomerase reverse transcriptase	Homo sapiens	83-88
34207376-5	2021	Long-term treatment with 100 mg/kg curcumin improved the ovarian reserve indicators of AMH, FSH, and estradiol in aging mice.	Curcumin	35-43	anti-Mullerian hormone	Mus musculus	87-90
27585262-6	2016	Scanning electron microscopy, MTT assays and real-time PCR were used for imaging, cytotoxicity testing and measuring the expression levels of hTERT after treatment of cells with different concentrations of free curcumin and curcumin loaded nanocarriers.	Curcumin	211-219	telomerase reverse transcriptase	Homo sapiens	142-147
27585262-6	2016	Scanning electron microscopy, MTT assays and real-time PCR were used for imaging, cytotoxicity testing and measuring the expression levels of hTERT after treatment of cells with different concentrations of free curcumin and curcumin loaded nanocarriers.	Curcumin	224-232	telomerase reverse transcriptase	Homo sapiens	142-147
27585262-8	2016	The hTERT expression levels were decreased by curcumin loaded PLGA-PEG more than curcumin loaded NIPAAm-MAA and free curcumin.	Curcumin	46-54	telomerase reverse transcriptase	Homo sapiens	4-9
34095313-7	2021	Treatment of 3D spheroids with curcumin decreased cell viability, accompanied by an increase in mediators of apoptosis and necroptosis, including cleaved caspase-3 and cleaved PARP, phospho (p)-RIP3, and p-MLKL proteins.	Curcumin	31-39	mixed lineage kinase domain like pseudokinase	Homo sapiens	206-210
27585262-8	2016	The hTERT expression levels were decreased by curcumin loaded PLGA-PEG more than curcumin loaded NIPAAm-MAA and free curcumin.	Curcumin	81-89	telomerase reverse transcriptase	Homo sapiens	4-9
27585262-8	2016	The hTERT expression levels were decreased by curcumin loaded PLGA-PEG more than curcumin loaded NIPAAm-MAA and free curcumin.	Curcumin	81-89	telomerase reverse transcriptase	Homo sapiens	4-9
27383887-7	2016	The inhibition of cell growth by curcumin (IC50 = 41.69 +- 2.87 mug mL-1) was much more effective than that of methanolic extract (IC50 = 196.12 +- 5.25 mug mL-1).	Curcumin	33-41	L1 cell adhesion molecule	Mus musculus	68-72
34374241-1	2021	Objective: To study the alleviating effects of curcumin on splenic inflammation in overtraining rats by regulating toll-like receptor 4 (TLR4)-p38 mitogen-activated protein kinase (p38 MAPK)/nuclear factor-kappa B (NF-kappaB) signaling pathway.	Curcumin	47-55	mitogen activated protein kinase 14	Rattus norvegicus	143-179
27383887-7	2016	The inhibition of cell growth by curcumin (IC50 = 41.69 +- 2.87 mug mL-1) was much more effective than that of methanolic extract (IC50 = 196.12 +- 5.25 mug mL-1).	Curcumin	33-41	L1 cell adhesion molecule	Mus musculus	157-161
27725901-7	2016	The molecular basis of curcumin-mediated cell growth inhibition we identified is that curcumin significantly suppressed Skp2 expression and subsequently induced p21 expression.	Curcumin	23-31	H3 histone pseudogene 16	Homo sapiens	161-164
27203664-9	2016	Curcumin mediated a further increase in the levels of interleukin (IL)-10.	Curcumin	0-8	interleukin 10	Rattus norvegicus	54-73
27452633-0	2016	Pharmacokinetic effects of curcumin on docetaxel mediated by OATP1B1, OATP1B3 and CYP450s.	Curcumin	27-35	solute carrier organic anion transporter family member 1B1	Homo sapiens	61-68
27452633-5	2016	Human embryonic kidney 293 (HEK293) cells stably expressing OATP1B1 and OATP1B3 were used to observe the effects of curcumin on OATP1B1 and OATP1B3-mediated uptake of docetaxel.	Curcumin	116-124	solute carrier organic anion transporter family member 1B1	Homo sapiens	128-135
27725901-7	2016	The molecular basis of curcumin-mediated cell growth inhibition we identified is that curcumin significantly suppressed Skp2 expression and subsequently induced p21 expression.	Curcumin	86-94	H3 histone pseudogene 16	Homo sapiens	161-164
27452633-6	2016	Curcumin exhibited potent inhibition on OATP1B1 and OATP1B3-mediated docetaxel uptake with IC50 values of 3.81 +- 1.19 muM and 33.70 +- 1.22 muM, respectively.	Curcumin	0-8	solute carrier organic anion transporter family member 1B1	Homo sapiens	40-47
34981469-9	2021	The expression levels of all tested genes were altered in all treatment groups compared to the control, with that of WNT1, CTNNB1, TCF, MTOR, AKT1, BIRC5, and CCND1 showing the most robust changes in the combined curcumin/berberine/5-FU treatment.	Curcumin	213-221	cyclin D1	Homo sapiens	159-164
27452633-8	2016	The preclinical and clinical improved docetaxel"s therapeutic efficacy when co-administrated with curcumin may be due to the inhibition of curcumin on OATP1B1, OATP1B3 and HLMs activities.	Curcumin	98-106	solute carrier organic anion transporter family member 1B1	Homo sapiens	151-158
27452633-8	2016	The preclinical and clinical improved docetaxel"s therapeutic efficacy when co-administrated with curcumin may be due to the inhibition of curcumin on OATP1B1, OATP1B3 and HLMs activities.	Curcumin	139-147	solute carrier organic anion transporter family member 1B1	Homo sapiens	151-158
34109908-8	2021	CONCLUSION: Curcumin could effectively inhibit NLRP1-dependent neuronal pyroptosis by suppressing the p38 MAPK pathway and therefore exerted neuroprotective effects against cerebral ischemia-reperfusion injury.	Curcumin	12-20	NLR family, pyrin domain containing 1A	Rattus norvegicus	47-52
27368802-6	2016	Due to this deletion mutant (hereupon called TM), GSK3beta and HDAC inhibitors failed to show any impact whereas curcumin significantly inhibited beta-catenin mediated transcriptional activity reiterating that TM is primarily responsible for the high transcriptional activity of HepG2 cells.	Curcumin	113-121	catenin beta 1	Homo sapiens	146-158
34131556-9	2021	Furthermore, representative docking complexes were validated using molecular dynamics simulations and mechanistic studies at 100 ns was carried on nucleocapsid and nsp10 proteins with curcumin complexes which resulted in stable and efficient binding energies and correlated with that of docked binding energies of the complexes.	Curcumin	184-192	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	164-169
27233000-6	2016	Furthermore, the protection of S-nitrosylation on IKKbeta in DSS-induced colitis for 6days by curcumin caused the repression of IkappaB phosphorylation and NF-kappaB activation.	Curcumin	94-102	inhibitor of kappaB kinase beta	Mus musculus	50-57
27502306-9	2016	Furthermore, we found that pro-apoptotic molecules including p-JNK and Bax were up-regulated in VSMCs treated with calcifying medium, but they were reduced in VSMCs after curcumin treatment.	Curcumin	171-179	mitogen-activated protein kinase 8	Rattus norvegicus	63-66
27502306-9	2016	Furthermore, we found that pro-apoptotic molecules including p-JNK and Bax were up-regulated in VSMCs treated with calcifying medium, but they were reduced in VSMCs after curcumin treatment.	Curcumin	171-179	BCL2 associated X, apoptosis regulator	Rattus norvegicus	71-74
27502306-11	2016	Taken together, these findings suggest that curcumin attenuates apoptosis and calcification of VSMCs, presumably via inhibition of JNK/Bax signaling pathway.	Curcumin	44-52	mitogen-activated protein kinase 8	Rattus norvegicus	131-134
27502306-11	2016	Taken together, these findings suggest that curcumin attenuates apoptosis and calcification of VSMCs, presumably via inhibition of JNK/Bax signaling pathway.	Curcumin	44-52	BCL2 associated X, apoptosis regulator	Rattus norvegicus	135-138
27551266-4	2016	Our present study in isolated testicular germ cell population from adult male Wistar rats, highlighted the synergistic protective effect of curcumin and resveratrol against B(a)P induced p53 mediated germ cell apoptosis.	Curcumin	140-148	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	187-190
27551266-8	2016	Curcumin-resveratrol co-treatment decreased Bax/Bcl2 ratio, mitochondria to cytosolic translocation of cytochrome c and activated the survival protein Akt.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	44-47
27551266-9	2016	Curcumin-resveratrol decreased the expression of p53 dependent apoptotic genes like Fas, FasL, Bax, Bcl2, and Apaf1.	Curcumin	0-8	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	49-52
27234697-9	2016	Annexin-V-PI test showed curcumin-induced apoptosis was enhanced in Huh7 as well as HepG2, compared to untreated cells.	Curcumin	25-33	annexin A5	Homo sapiens	0-9
27261602-2	2016	The present study was aimed to investigate the role of curcumin in myocardial infarction (MI) and its potential mechanism involving transcription factor specific protein 1 (SP1).	Curcumin	55-63	trans-acting transcription factor 1	Mus musculus	153-171
26242398-0	2016	HSP27 modulates survival signaling in endosulfan-exposed human peripheral blood mononuclear cells treated with curcumin.	Curcumin	111-119	heat shock protein family B (small) member 1	Homo sapiens	0-5
26242398-7	2016	The present study indicates that the beneficial effect of curcumin on endosulfan-induced cytotoxicity is related to the induced synthesis of HSP27, emphasizing its antioxidant and therapeutic potential as well as underscoring the mechanism of pesticide-induced toxicity at cellular level.	Curcumin	58-66	heat shock protein family B (small) member 1	Homo sapiens	141-146
35504740-0	2022	Retraction notice to "Curcumin inhibits proliferation and soluble collagen synthesis of NIH/3T3 cell line by modulation of miR-29a and via ERK1/2 and beta-catenin pathways" (Mol.	Curcumin	22-30	microRNA 29a	Mus musculus	123-130
27489587-0	2016	Curcumin Veto the Effects of Osteopontin (OPN) Specific Inhibitor on Leukemic Stem Cell Colony Forming Potential via Promotion of OPN Overexpression.	Curcumin	0-8	secreted phosphoprotein 1	Homo sapiens	29-40
27489587-0	2016	Curcumin Veto the Effects of Osteopontin (OPN) Specific Inhibitor on Leukemic Stem Cell Colony Forming Potential via Promotion of OPN Overexpression.	Curcumin	0-8	secreted phosphoprotein 1	Homo sapiens	42-45
27551266-9	2016	Curcumin-resveratrol decreased the expression of p53 dependent apoptotic genes like Fas, FasL, Bax, Bcl2, and Apaf1.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	95-98
27551266-11	2016	Curcumin-resveratrol co-treatment prevented B(a)P induced nuclear translocation of AhR and CYP1A1 (Cytochrome P4501A1) expression.	Curcumin	0-8	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	91-97
27489587-0	2016	Curcumin Veto the Effects of Osteopontin (OPN) Specific Inhibitor on Leukemic Stem Cell Colony Forming Potential via Promotion of OPN Overexpression.	Curcumin	0-8	secreted phosphoprotein 1	Homo sapiens	130-133
27551266-11	2016	Curcumin-resveratrol co-treatment prevented B(a)P induced nuclear translocation of AhR and CYP1A1 (Cytochrome P4501A1) expression.	Curcumin	0-8	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	99-117
35504740-0	2022	Retraction notice to "Curcumin inhibits proliferation and soluble collagen synthesis of NIH/3T3 cell line by modulation of miR-29a and via ERK1/2 and beta-catenin pathways" (Mol.	Curcumin	22-30	mitogen-activated protein kinase 3	Mus musculus	139-145
27551266-14	2016	Curcumin-resveratrol co-treatment significantly decreased p53 level and its phosphorylation (p53 ser 15).	Curcumin	0-8	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	58-61
27551266-14	2016	Curcumin-resveratrol co-treatment significantly decreased p53 level and its phosphorylation (p53 ser 15).	Curcumin	0-8	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	93-96
27489587-4	2016	Therefore, the aim of this study was to evaluate OPN roles in modulating curcumin-mediated growth inhibitory on leukemic stem cells (LSCs) colony forming potential and survival in AML cell lines and primary CD34+/CD38- bone marrow-derived AML cells.	Curcumin	73-81	secreted phosphoprotein 1	Homo sapiens	49-52
27278959-7	2016	Moreover, curcumin decreased the expression of hexokinase (HK), phosphofructokinase-2 (PFK2), and glucose transporter 4 (glut4), three key glycolytic parameters, at both mRNA and protein levels.	Curcumin	10-18	solute carrier family 2 member 4	Rattus norvegicus	98-119
27551266-15	2016	The study concludes that curcumin-resveratrol synergistically modulated MAPKs and p53, prevented oxidative stress, regulated the expression of pro and anti-apoptotic proteins as well as the proteins involved in B(a)P metabolism thus protected germ cells from B(a)P induced apoptosis.	Curcumin	25-33	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	82-85
27278959-7	2016	Moreover, curcumin decreased the expression of hexokinase (HK), phosphofructokinase-2 (PFK2), and glucose transporter 4 (glut4), three key glycolytic parameters, at both mRNA and protein levels.	Curcumin	10-18	solute carrier family 2 member 4	Rattus norvegicus	121-126
35341883-0	2022	beta-Cyclodextrin encapsulation of curcumin elicits an altered mode of angiogenin inhibition: In vitro and in vivo studies.	Curcumin	35-43	angiogenin	Homo sapiens	71-81
27525306-9	2016	Finally, in the experimental mouse model, we showed that curcumin inhibited HGF-stimulated tumor growth and induced an increase in E-cadherin expression and a decrease in vimentin, CD34, and vascular endothelial growth factor (VEGF) expression.	Curcumin	57-65	CD34 antigen	Mus musculus	181-185
27470399-6	2016	Within-group analysis revealed significant reductions in serum concentrations of TNF-alpha, IL-6, TGF-beta and MCP-1 following curcumin supplementation (p&lt;0.001).	Curcumin	127-135	C-C motif chemokine ligand 2	Homo sapiens	111-116
27470399-8	2016	Between-group comparison suggested significantly greater reductions in serum concentrations of TNF-alpha, IL-6, TGF-beta and MCP-1 in the curcumin versus placebo group (p&lt;0.001).	Curcumin	138-146	C-C motif chemokine ligand 2	Homo sapiens	125-130
35341883-1	2022	The interaction of curcumin (Cur) with human angiogenin (hAng), a potent blood vessel inducer responsible for angiogenesis is found to change following encapsulation within the beta-cyclodextrin (betaCD) cavity.	Curcumin	19-27	angiogenin	Homo sapiens	45-55
27556215-7	2016	Further studies demonstrated that curcumin treatment (20 muM) significantly inhibited proinflammatory factors, including IL-6, ELAM-1, IL-1alpha, and IL-8, whereas it decreased activities of senescence marker SA-beta-gal, and lowered levels of carbonylated proteins and apoptotic cell numbers.	Curcumin	34-42	selectin E	Homo sapiens	127-133
27556215-7	2016	Further studies demonstrated that curcumin treatment (20 muM) significantly inhibited proinflammatory factors, including IL-6, ELAM-1, IL-1alpha, and IL-8, whereas it decreased activities of senescence marker SA-beta-gal, and lowered levels of carbonylated proteins and apoptotic cell numbers.	Curcumin	34-42	interleukin 1 alpha	Homo sapiens	135-144
27338805-5	2016	In this work, we selected various curcumin analogs and studied their toxicity, stability and efficacy to interact with different alpha-Syn species and modulation of their toxicity.	Curcumin	34-42	synuclein alpha	Homo sapiens	129-138
27338805-6	2016	We found a subset of curcumin analogs with higher stability and showed that curcumin and its various analogs interact with preformed fibrils and oligomers and accelerate alpha-Syn aggregation to produce morphologically different amyloid fibrils in vitro.	Curcumin	76-84	synuclein alpha	Homo sapiens	170-179
27338805-7	2016	Furthermore, these curcumin analogs showed differential binding with the preformed alpha-Syn aggregates.	Curcumin	19-27	synuclein alpha	Homo sapiens	83-92
27338805-8	2016	The present data suggest the potential role of curcumin analogs in modulating alpha-Syn aggregation.	Curcumin	47-55	synuclein alpha	Homo sapiens	78-87
27405665-3	2016	We first demonstrated that curcumin, like docetaxel (DTX), can selectively target CD11b(+)Ly6G(+)Ly6C(low) granulocytic (G)-MDSCs, sparing CD11b(+)Ly6G(-)Ly6C(high) M-MDSCs, with reduced tumor burden in 4T1-Neu tumor-bearing mice.	Curcumin	27-35	lymphocyte antigen 6 complex, locus C1	Mus musculus	97-101
27405665-3	2016	We first demonstrated that curcumin, like docetaxel (DTX), can selectively target CD11b(+)Ly6G(+)Ly6C(low) granulocytic (G)-MDSCs, sparing CD11b(+)Ly6G(-)Ly6C(high) M-MDSCs, with reduced tumor burden in 4T1-Neu tumor-bearing mice.	Curcumin	27-35	lymphocyte antigen 6 complex, locus C1	Mus musculus	154-158
35341883-1	2022	The interaction of curcumin (Cur) with human angiogenin (hAng), a potent blood vessel inducer responsible for angiogenesis is found to change following encapsulation within the beta-cyclodextrin (betaCD) cavity.	Curcumin	19-27	angiogenin	Homo sapiens	57-61
27324595-8	2016	In vitro and in vivo evaluations demonstrated efficacious synergistic antitumor effects against CT26 of curcumin and docetaxel combined nanofibrous microspheres.	Curcumin	104-112	DEAD-box helicase 53	Homo sapiens	96-100
35313339-10	2022	Induction of autophagy by curcumin, an autophagic stimulator, inhibited the expression of PD-L1 and enhanced cytolytic activity of NCL-specific T cells.	Curcumin	26-34	nucleolin	Homo sapiens	131-134
27258084-8	2016	In the present study, we performed in silico studies to quantitatively scrutinize the molecular interaction of curcumin and its structural analogs with COX-2, COX-1, FXa and integrin alphaIIbbetaIII to investigate their therapeutic potential as a cardiovascular-safe anti-inflammatory medicine (CVSAIM).	Curcumin	111-119	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	159-164
27220352-5	2016	Knockdown of mitogen-activated protein kinase alpha1/2alpha with siRNAs diminished such effects of curcumin.	Curcumin	99-107	adrenoceptor alpha 1D	Homo sapiens	46-59
27220352-7	2016	Curcumin reduced FFA influx into the liver by blocking FFA trafficking, and then prevented diacylglycerol deposits and PKCepsilon translocation in the liver, resultantly improving insulin action in the suppression of hepatic gluconeogenesis.	Curcumin	0-8	protein kinase C epsilon	Homo sapiens	119-129
35571134-9	2022	The results showed that curcumin significantly inhibited heme-induced oxidative stress, decreased intracellular ROS and MDA, and promoted Nrf2 and its downstream antioxidant gene (HO-1, NQO1, and Gpx4) expression.	Curcumin	24-32	glutathione peroxidase 4	Rattus norvegicus	196-200
25963729-8	2016	Curcumin-mediated neuroprotection against BPA-induced neurotoxicity involved activation of the Wnt/beta-catenin signaling pathway, which was confirmed by the use of Wnt specific activators (LiCl and GSK-3beta siRNA) and inhibitor (Dkk-1).	Curcumin	0-8	catenin beta 1	Rattus norvegicus	99-111
25963729-9	2016	BPA-mediated increased beta-catenin phosphorylation, decreased GSK-3beta levels, and beta-catenin nuclear translocation were significantly reversed by curcumin, leading to enhanced neurogenesis.	Curcumin	151-159	catenin beta 1	Rattus norvegicus	23-35
25963729-9	2016	BPA-mediated increased beta-catenin phosphorylation, decreased GSK-3beta levels, and beta-catenin nuclear translocation were significantly reversed by curcumin, leading to enhanced neurogenesis.	Curcumin	151-159	catenin beta 1	Rattus norvegicus	85-97
27039889-0	2016	Curcumin directly inhibits the transport activity of GLUT1.	Curcumin	0-8	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	53-58
35431006-5	2022	In addition, HN5 cells were also treated with curcumin to evaluate its effect on the caspase-8, -9, Bcl-2, Bax, and Stat3 genes expression.	Curcumin	46-54	caspase 8	Homo sapiens	85-98
27039889-4	2016	Therefore, this study investigates the effects of curcumin in cell lines where the major transporter is GLUT1.	Curcumin	50-58	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	104-109
25963729-12	2016	Overall, our results conclude that curcumin provides neuroprotection against BPA-mediated impaired neurogenesis via activation of the Wnt/beta-catenin signaling pathway.	Curcumin	35-43	catenin beta 1	Rattus norvegicus	138-150
35458704-0	2022	Curcumin Facilitates Aryl Hydrocarbon Receptor Activation to Ameliorate Inflammatory Astrogliosis.	Curcumin	0-8	aryl hydrocarbon receptor	Homo sapiens	21-46
26815506-0	2016	Curcumin analogue, A13, exhibits anti-leukemia effect via inhibiting STAT3.	Curcumin	0-8	UDP glycosyltransferase 1 family, polypeptide A10	Mus musculus	19-22
27039889-11	2016	Taken together, the data suggest that curcumin binds directly to GLUT1 at a site that overlaps with the cytochalasin B binding site and thereby inhibits glucose transport.	Curcumin	38-46	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	65-70
27039889-12	2016	A direct inhibition of GLUT proteins in intestinal epithelial cells would likely reduce absorption of dietary glucose and contribute to a hypoglycemic effect of curcumin.	Curcumin	161-169	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	23-27
27039889-13	2016	Also, inhibition of GLUT1 activity might compromise cancer cells that overexpress GLUT1 and be another possible mechanism for the documented anticancer effects of curcumin.	Curcumin	163-171	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	20-25
26815506-2	2016	In this study, we tested the anti-tumor effect of compound A13, a water-soluble analogue of curcumin, in vitro and in vivo.	Curcumin	92-100	UDP glycosyltransferase 1 family, polypeptide A10	Mus musculus	59-62
35458704-3	2022	However, the AhR-mediated anti-inflammatory effect of curcumin within the brain remains unclear.	Curcumin	54-62	aryl hydrocarbon receptor	Homo sapiens	13-16
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	zinc finger E-box binding homeobox 2	Homo sapiens	154-158
35458704-6	2022	When AhR was knocked down, LPS-induced IL-6 and TNF-alpha were increased and curcumin-decreased activation of the inflammation mediator NF-kappaB p65 by LPS was abolished.	Curcumin	77-85	RELA proto-oncogene, NF-kB subunit	Homo sapiens	146-149
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	AXL receptor tyrosine kinase	Homo sapiens	174-177
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	vimentin	Homo sapiens	179-187
27150945-0	2016	Characteristics and cytotoxicity of folate-modified curcumin-loaded PLA-PEG micellar nano systems with various PLA:PEG ratios.	Curcumin	52-60	progestagen associated endometrial protein	Homo sapiens	72-75
27150945-0	2016	Characteristics and cytotoxicity of folate-modified curcumin-loaded PLA-PEG micellar nano systems with various PLA:PEG ratios.	Curcumin	52-60	progestagen associated endometrial protein	Homo sapiens	115-118
27150945-2	2016	In this study, we synthesized curcumin (Cur) loaded (D, L Poly lactic - Poly ethylenglycol) micelle (Cur/PLA-PEG) with the ratio of PLA/PEG of 3:1 2:1 1:1 1:2 and 1:3 (w/w) and another micelle modified by folate (Cur/PLA-PEG-Fol) for targeting cancer therapy.	Curcumin	30-38	progestagen associated endometrial protein	Homo sapiens	109-112
26872103-0	2016	Curcumin Ameliorates Reserpine-Induced Gastrointestinal Mucosal Lesions Through Inhibiting IkappaB-alpha/NF-kappaB Pathway and Regulating Expression of Vasoactive Intestinal Peptide and Gastrin in Rats.	Curcumin	0-8	NFKB inhibitor alpha	Rattus norvegicus	91-104
26872103-10	2016	Curcumin can target the IkappaB-alpha/NF-kappaB pathway to inhibit inflammatory response and regulate the level of VIP and gastrin in reserpine-induced GML rats.	Curcumin	0-8	NFKB inhibitor alpha	Rattus norvegicus	24-37
35178811-2	2022	This study aimed to investigate the effects of curcumin supplementation on metabolic parameters (lipid profile and glycemic indices), inflammatory factors, visfatin levels, and obesity values in women with RA.	Curcumin	47-55	nicotinamide phosphoribosyltransferase	Homo sapiens	156-164
35362381-12	2022	CONCLUSIONS: Curcumin decreased the fructose-induced glycation level of the ACO2, NDUFS7, and DLAT proteins.	Curcumin	13-21	aconitase 2, mitochondrial	Mus musculus	76-80
27050372-0	2016	Curcumin modulates chronic myelogenous leukemia exosomes composition and affects angiogenic phenotype via exosomal miR-21.	Curcumin	0-8	microRNA 21	Homo sapiens	115-121
35362381-12	2022	CONCLUSIONS: Curcumin decreased the fructose-induced glycation level of the ACO2, NDUFS7, and DLAT proteins.	Curcumin	13-21	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	94-98
27050372-3	2016	Exosomes released by CML cells treated with Curcumin contain a high amount of miR-21 that is shuttled into the endothelial cells in a biologically active form.	Curcumin	44-52	microRNA 21	Homo sapiens	78-84
27150945-2	2016	In this study, we synthesized curcumin (Cur) loaded (D, L Poly lactic - Poly ethylenglycol) micelle (Cur/PLA-PEG) with the ratio of PLA/PEG of 3:1 2:1 1:1 1:2 and 1:3 (w/w) and another micelle modified by folate (Cur/PLA-PEG-Fol) for targeting cancer therapy.	Curcumin	30-38	progestagen associated endometrial protein	Homo sapiens	136-139
27150945-2	2016	In this study, we synthesized curcumin (Cur) loaded (D, L Poly lactic - Poly ethylenglycol) micelle (Cur/PLA-PEG) with the ratio of PLA/PEG of 3:1 2:1 1:1 1:2 and 1:3 (w/w) and another micelle modified by folate (Cur/PLA-PEG-Fol) for targeting cancer therapy.	Curcumin	30-38	progestagen associated endometrial protein	Homo sapiens	136-139
26945822-0	2016	Cannabinoid receptors are involved in the protective effect of a novel curcumin derivative C66 against CCl4-induced liver fibrosis.	Curcumin	71-79	C-C motif chemokine ligand 4	Homo sapiens	103-107
35399832-7	2022	Results: With curcumin concentration increasing, the expressions of MMP2, MMP9, MTOR, and p-MTOR proteins and the number of cells in the S phase decreased gradually, while number of cells in G1 and G2/M phases and cells apoptosis rate increased continuously.	Curcumin	14-22	matrix metallopeptidase 2	Homo sapiens	68-72
26945822-4	2016	The current study aimed to investigate whether a more stable derivative of curcumin, C66, protects against CCl4-inudced liver fibrosis and examine the underlying mechanism involving cannabinoid receptor (CB receptor).	Curcumin	75-83	C-C motif chemokine ligand 4	Homo sapiens	107-111
26862043-1	2016	The aim of the study was to investigate the ameliorative effects of curcumin on fibrinogen like protein-2 (fgl-2), some oxido-inflammatory and apoptotic markers in rat-induced acute pancreatitis (AP).	Curcumin	68-76	fibrinogen-like 2	Rattus norvegicus	80-105
26862043-1	2016	The aim of the study was to investigate the ameliorative effects of curcumin on fibrinogen like protein-2 (fgl-2), some oxido-inflammatory and apoptotic markers in rat-induced acute pancreatitis (AP).	Curcumin	68-76	fibrinogen-like 2	Rattus norvegicus	107-112
27026486-8	2016	Moreover, Western blot analysis and immunostaining indicated that treatment with curcumin significantly reduced the expression of a vascular cell adhesion molecule-1 (VCAM-1), interferon-gamma (INF-gamma) and interleukin-17 (IL-17) in the mouse brain at 72h post-ICH.	Curcumin	81-89	vascular cell adhesion molecule 1	Mus musculus	132-165
27026486-8	2016	Moreover, Western blot analysis and immunostaining indicated that treatment with curcumin significantly reduced the expression of a vascular cell adhesion molecule-1 (VCAM-1), interferon-gamma (INF-gamma) and interleukin-17 (IL-17) in the mouse brain at 72h post-ICH.	Curcumin	81-89	vascular cell adhesion molecule 1	Mus musculus	167-173
35453298-1	2022	The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose activity can be modulated by polyphenols, such as curcumin.	Curcumin	135-143	aryl hydrocarbon receptor	Homo sapiens	31-34
25980682-5	2016	Curcumin activated ER-resident UPR sensors, such as PERK, IRE-1alpha, and ATF6, and their downstream-signaling proteins in cervical cancer cells, but not in normal epithelial cells and peripheral blood mononuclear cells (PBMCs).	Curcumin	0-8	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	52-56
25980682-5	2016	Curcumin activated ER-resident UPR sensors, such as PERK, IRE-1alpha, and ATF6, and their downstream-signaling proteins in cervical cancer cells, but not in normal epithelial cells and peripheral blood mononuclear cells (PBMCs).	Curcumin	0-8	activating transcription factor 6	Homo sapiens	74-78
27035875-4	2016	By immunofluorescence staining, subcellular fractionation and western blotting, the present study demonstrated that curcumin was able to induce G2/M cell cycle arrest and apoptosis by increasing the expression levels of cyclin G2, cleaved caspase-3 and Fas ligand (FasL), and decreasing the expression of cyclin-dependent kinase 1 (CDK1).	Curcumin	116-124	Fas ligand	Homo sapiens	253-263
27035875-4	2016	By immunofluorescence staining, subcellular fractionation and western blotting, the present study demonstrated that curcumin was able to induce G2/M cell cycle arrest and apoptosis by increasing the expression levels of cyclin G2, cleaved caspase-3 and Fas ligand (FasL), and decreasing the expression of cyclin-dependent kinase 1 (CDK1).	Curcumin	116-124	Fas ligand	Homo sapiens	265-269
27035875-4	2016	By immunofluorescence staining, subcellular fractionation and western blotting, the present study demonstrated that curcumin was able to induce G2/M cell cycle arrest and apoptosis by increasing the expression levels of cyclin G2, cleaved caspase-3 and Fas ligand (FasL), and decreasing the expression of cyclin-dependent kinase 1 (CDK1).	Curcumin	116-124	cyclin dependent kinase 1	Homo sapiens	305-330
27035875-4	2016	By immunofluorescence staining, subcellular fractionation and western blotting, the present study demonstrated that curcumin was able to induce G2/M cell cycle arrest and apoptosis by increasing the expression levels of cyclin G2, cleaved caspase-3 and Fas ligand (FasL), and decreasing the expression of cyclin-dependent kinase 1 (CDK1).	Curcumin	116-124	cyclin dependent kinase 1	Homo sapiens	332-336
27035875-7	2016	Furthermore, following knockdown of FoxO1 expression in curcumin-treated U87 cells using FoxO1 small interfering RNA, the expression levels of cyclin G2, cleaved caspase-3 and FasL were inhibited; however, the expression levels of CDK1 were not markedly altered.	Curcumin	56-64	Fas ligand	Homo sapiens	176-180
27035875-7	2016	Furthermore, following knockdown of FoxO1 expression in curcumin-treated U87 cells using FoxO1 small interfering RNA, the expression levels of cyclin G2, cleaved caspase-3 and FasL were inhibited; however, the expression levels of CDK1 were not markedly altered.	Curcumin	56-64	cyclin dependent kinase 1	Homo sapiens	231-235
27010501-0	2016	Evaluation of the anti-inflammatory action of curcumin analog (DM1): Effect on iNOS and COX-2 gene expression and autophagy pathways.	Curcumin	46-54	immunoglobulin heavy diversity 1-7	Homo sapiens	63-66
27010501-0	2016	Evaluation of the anti-inflammatory action of curcumin analog (DM1): Effect on iNOS and COX-2 gene expression and autophagy pathways.	Curcumin	46-54	inositol-3-phosphate synthase 1	Homo sapiens	79-83
26682581-5	2016	RESULTS: Curcumin treatment was found to significantly lower elevated tissue malondialdehyde levels and myeloperoxidase activity, and to raise reduced glutathione levels in intestinal tissues samples.	Curcumin	9-17	myeloperoxidase	Rattus norvegicus	104-119
27313684-0	2016	MiR-593 mediates curcumin-induced radiosensitization of nasopharyngeal carcinoma cells via MDR1.	Curcumin	17-25	microRNA 593	Homo sapiens	0-7
27001816-5	2016	When curcumin and Bz were combined, there was a drastic reduction in parasitemia, parasite load, mortality, anti-T. cruzi IgG reactivity, circulating levels of cytokines (gamma interferon [IFN-gamma], interleukin 4 [IL-4], and MIP1-alpha), myocardial inflammation, and morphological and oxidative cardiac injury; these results exceeded the isolated effects of Bz.	Curcumin	5-13	interleukin 4	Mus musculus	201-214
27001816-5	2016	When curcumin and Bz were combined, there was a drastic reduction in parasitemia, parasite load, mortality, anti-T. cruzi IgG reactivity, circulating levels of cytokines (gamma interferon [IFN-gamma], interleukin 4 [IL-4], and MIP1-alpha), myocardial inflammation, and morphological and oxidative cardiac injury; these results exceeded the isolated effects of Bz.	Curcumin	5-13	interleukin 4	Mus musculus	216-220
27010501-1	2016	This work describes the anti-inflammatory effect of the curcumin-analog compound, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate (DM1), and shows that DM1 modulates iNOS and COX-2 gene expression in cultured RAW 264.7 cells and induces autophagy on human melanoma cell line A375.	Curcumin	56-64	immunoglobulin heavy diversity 1-7	Homo sapiens	167-170
27010501-1	2016	This work describes the anti-inflammatory effect of the curcumin-analog compound, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate (DM1), and shows that DM1 modulates iNOS and COX-2 gene expression in cultured RAW 264.7 cells and induces autophagy on human melanoma cell line A375.	Curcumin	56-64	immunoglobulin heavy diversity 1-7	Homo sapiens	188-191
35453298-4	2022	Using a combination of in vivo, in vitro, and in silico analyses, we demonstrated that curcumin has AhR-dependent or -independent effects in a context-specific manner.	Curcumin	87-95	aryl hydrocarbon receptor	Homo sapiens	100-103
26826458-4	2016	Results showed that, 10 muM of curcumin significantly inhibited secretion of inflammatory factors including interleukin (IL)-17,IL-22, IFN-gamma, IL-2, IL-8 and TNF-alpha in T cells by 30-60% in vitro.	Curcumin	31-39	interleukin 22	Mus musculus	128-133
26826458-4	2016	Results showed that, 10 muM of curcumin significantly inhibited secretion of inflammatory factors including interleukin (IL)-17,IL-22, IFN-gamma, IL-2, IL-8 and TNF-alpha in T cells by 30-60% in vitro.	Curcumin	31-39	interleukin 2	Mus musculus	128-132
27001816-5	2016	When curcumin and Bz were combined, there was a drastic reduction in parasitemia, parasite load, mortality, anti-T. cruzi IgG reactivity, circulating levels of cytokines (gamma interferon [IFN-gamma], interleukin 4 [IL-4], and MIP1-alpha), myocardial inflammation, and morphological and oxidative cardiac injury; these results exceeded the isolated effects of Bz.	Curcumin	5-13	chemokine (C-C motif) ligand 3	Mus musculus	227-237
26826458-8	2016	More than 50% level of inflammatory factors including TNF-alpha, IFN-gamma, IL-2, IL-12, IL-22 and IL-23 in mouse serum was decreased by curcumin treatment as well as cyclosporine.	Curcumin	137-145	interleukin 2	Mus musculus	76-80
27049834-5	2016	Curcumin inhibited the expression of EZH2 through microRNA (miR)-let 7c and miR-101.	Curcumin	0-8	microRNA let-7c	Homo sapiens	65-71
35453298-5	2022	We found that in Caenorhabditis elegans, AhR mediates curcumin-induced lifespan extension, most likely through a ligand-independent inhibitory mechanism related to its antioxidant activity.	Curcumin	54-62	aryl hydrocarbon receptor	Homo sapiens	41-44
26826458-8	2016	More than 50% level of inflammatory factors including TNF-alpha, IFN-gamma, IL-2, IL-12, IL-22 and IL-23 in mouse serum was decreased by curcumin treatment as well as cyclosporine.	Curcumin	137-145	interleukin 22	Mus musculus	89-94
35453298-6	2022	Curcumin also showed AhR-independent anti-aging activities, such as protection against aggregation-prone proteins and oxidative stress in C. elegans and promotion of the migratory capacity of human primary endothelial cells.	Curcumin	0-8	aryl hydrocarbon receptor	Homo sapiens	21-24
26992258-6	2016	Curcumin treatment reduced the TGF-beta1 and fibronectin activation and the inhibiting effect of diabetes on Wnt5a/beta-catenin expression in renal glomeruli.	Curcumin	0-8	fibronectin 1	Rattus norvegicus	45-56
26992258-6	2016	Curcumin treatment reduced the TGF-beta1 and fibronectin activation and the inhibiting effect of diabetes on Wnt5a/beta-catenin expression in renal glomeruli.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	115-127
35063475-10	2022	In addition, curcumin significantly reduced the characteristic indices of AFB1-induced pyroptosis, such as the expression of mRNAs for genes related to NOD-like receptor protein 3 (NLRP3) inflammasome assembly and activation, the expression of key proteins (NLRP3, Caspase-1 and GSDMD).	Curcumin	13-21	caspase 1	Mus musculus	265-274
26992258-7	2016	Immunohistochemistry showed that curcumin treatment significantly reduced 8-hydroxy-2"-deoxyguanosine, TGF-beta1 and fibronectin, and was in line with the restoration of the suppressed Wnt5a expression immunoreactivities in glomeruli of diabetic rats.	Curcumin	33-41	fibronectin 1	Rattus norvegicus	117-128
26992258-8	2016	Curcumin alleviated extracellular matrix accumulation in diabetic nephropathy by not only preventing the diabetes-mediated superoxide synthesis but also resuming downregulation of Wnt/beta-catenin signaling.	Curcumin	0-8	Wnt family member 2	Rattus norvegicus	180-183
26992258-8	2016	Curcumin alleviated extracellular matrix accumulation in diabetic nephropathy by not only preventing the diabetes-mediated superoxide synthesis but also resuming downregulation of Wnt/beta-catenin signaling.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	184-196
26878325-1	2016	The purpose of this study was to develop folic acid functionalized long-circulating co-encapsulated docetaxel (DTX) and curcumin (CRM) solid lipid nanoparticles (F-DC-SLN) to improve the pharmacokinetic and efficacy of DTX therapy.	Curcumin	130-133	sarcolipin	Homo sapiens	167-170
35080289-0	2022	Curcumin suppress inflammatory response in traumatic brain injury via p38/MAPK signaling pathway.	Curcumin	0-8	mitogen-activated protein kinase 14	Mus musculus	70-73
27063991-3	2016	The aim of this study was to explore OPN roles in modulating curcumin-mediated LSC enrichment and survival in AML cell lines and primary CD34+/CD38- bone-marrow-derived AML cells.	Curcumin	61-69	secreted phosphoprotein 1	Homo sapiens	37-40
26992258-9	2016	These findings suggest that regulation of Wnt activity by curcumin is a feasible alternative strategy to rescue diabetic renal injury.	Curcumin	58-66	Wnt family member 2	Rattus norvegicus	42-45
26937210-0	2016	Curcumin protects against the intestinal ischemia-reperfusion injury: involvement of the tight junction protein ZO-1 and TNF-alpha related mechanism.	Curcumin	0-8	tight junction protein 1	Rattus norvegicus	112-116
26937210-9	2016	I/R insult also induced significantly down-regulated expression of ZO-1, and the eff ect was dramatically attenuated by curcumin-pretreatment.	Curcumin	120-128	tight junction protein 1	Rattus norvegicus	67-71
26937210-10	2016	Curcumin may protect the intestine from I/R injury through restoration of the epithelial structure, promotion of the recovery of intestinal permeability, as well as enhancement of ZO-1 protein expression, and this eff ect may be partly attributed to the TNF-alpha related pathway.	Curcumin	0-8	tight junction protein 1	Rattus norvegicus	180-184
26502886-0	2016	Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP.	Curcumin	0-8	BCR pseudogene 1	Homo sapiens	101-105
26502886-9	2016	CONCLUSIONS: These results suggest that curcumin alters the phase II distribution of resveratrol through inhibiting efflux transporters including MRP2 and BCRP.	Curcumin	40-48	BCR pseudogene 1	Homo sapiens	155-159
35080289-7	2022	Additionally, curcumin notably reduced the expression of p-p38 according to western blotting and immunohistochemical analyses.	Curcumin	14-22	mitogen-activated protein kinase 14	Mus musculus	59-62
35205780-9	2022	As curcumin"s mode of action, inhibition of NF-kappaB p65 activation via IkappaBalpha was identified.	Curcumin	3-11	RELA proto-oncogene, NF-kB subunit	Homo sapiens	44-57
28875685-8	2016	Network pharmacology analysis using ingenuity pathway analysis (IPA) software revealed that TCM-derived drugs interacting with AMPK target proteins included berberine, emodin, curcumin, resveratrol, alcohol, cordyceps, arctiin, suggesting in a certain extent the feasibility of "medicine -food homology" drugs to extend the lifespan through the AMPK pathway.	Curcumin	176-184	AMP-activated protein kinase alpha subunit	Drosophila melanogaster	127-131
35163692-4	2022	Accordingly, curcumin and similar compounds and analogues were retrieved and assessed for their binding affinities at the binding pocket of SARS-CoV-2 main protease and DDX3.	Curcumin	13-21	DEAD-box helicase 3 X-linked	Homo sapiens	169-173
26422756-9	2016	H2S also increased activator protein 1 (AP-1) binding activity with SIRT3 promoter and this effect was absent in the presence of the specific AP-1 inhibitor, SR11302 or curcumin.	Curcumin	169-177	sirtuin 3	Mus musculus	68-73
26796279-7	2016	The results indicated that curcumin induced cell cycle arrest at G2/M phase by downregulation of cyclin B1 and Cdc2 and inhibited colony formation in MCF-7wt cells.	Curcumin	27-35	cyclin B1	Homo sapiens	97-106
26796279-7	2016	The results indicated that curcumin induced cell cycle arrest at G2/M phase by downregulation of cyclin B1 and Cdc2 and inhibited colony formation in MCF-7wt cells.	Curcumin	27-35	cyclin dependent kinase 1	Homo sapiens	111-115
26985708-0	2016	Curcumin inhibits tumor epithelial-mesenchymal transition by downregulating the Wnt signaling pathway and upregulating NKD2 expression in colon cancer cells.	Curcumin	0-8	NKD inhibitor of WNT signaling pathway 2	Homo sapiens	119-123
26985708-8	2016	The results showed that curcumin significantly inhibited the proliferation of colorectal cancer cells and upregulated the expression of NKD2 in SW620 colorectal cancer cells and in the xenograft, resulting in the downregulation of key markers in the Wnt signaling.	Curcumin	24-32	NKD inhibitor of WNT signaling pathway 2	Homo sapiens	136-140
27043868-5	2016	The objective of this study is to examine whether silymarin alone or in combination with vitamin E and/or curcumin plays a modulatory role against MAPK, STAT3, AKT, Smad-2 and TGF-beta protein expressions that produced apoptotic damage in rat"s liver by the administration of carbon tetrachloride (CCl4).	Curcumin	106-114	signal transducer and activator of transcription 3	Rattus norvegicus	153-158
27043868-5	2016	The objective of this study is to examine whether silymarin alone or in combination with vitamin E and/or curcumin plays a modulatory role against MAPK, STAT3, AKT, Smad-2 and TGF-beta protein expressions that produced apoptotic damage in rat"s liver by the administration of carbon tetrachloride (CCl4).	Curcumin	106-114	SMAD family member 2	Rattus norvegicus	165-171
26991801-0	2016	Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1.	Curcumin	63-71	fibronectin 1	Mus musculus	81-84
26991801-2	2016	FN1 is a synthetic curcumin analogue that shows stronger anticancer activity than curcumin in other reports.	Curcumin	19-27	fibronectin 1	Mus musculus	0-3
26991801-2	2016	FN1 is a synthetic curcumin analogue that shows stronger anticancer activity than curcumin in other reports.	Curcumin	82-90	fibronectin 1	Mus musculus	0-3
27091625-5	2016	Transcriptomic profiling revealed the up-regulation of three NF-kappaB-regulated CXC-chemokines, CXCL8, CXCL1 and CXCL2, in the resistant cells that were more efficiently down-regulated after OXA + Curcumin treatment as compared to the sensitive cells.	Curcumin	198-206	C-X-C motif chemokine ligand 2	Homo sapiens	114-119
26761722-5	2016	These investigations suggest that intranasal curcumin (2.5 and 5.0 mg/kg) regulates airway inflammation and airway obstruction mainly by modulating cytokine levels (IL-4, 5, IFN-y and TNF-alpha) and sPLA2 activity thereby inhibiting PGD2 release and COX-2 expression.	Curcumin	45-53	interleukin 4	Mus musculus	165-179
26978516-6	2016	Furthermore, curcumin significantly increased key mRNA levels of HK2, PKM2, LDHA, CES, Cpt1, Cpt2, FASN, and ATP5b and decreased levels of GLUT2 and ACC1 to enhance glycolysis and inhibit lipid metabolism and TCA cycle.	Curcumin	13-21	solute carrier family 2 member 2	Rattus norvegicus	139-144
35093937-0	2022	Correction for: Curcumin in combination with homoharringtonine suppresses lymphoma cell growth by inhibiting the TGF-beta/Smad3 signaling pathway.	Curcumin	16-24	transforming growth factor alpha	Homo sapiens	113-121
26978516-6	2016	Furthermore, curcumin significantly increased key mRNA levels of HK2, PKM2, LDHA, CES, Cpt1, Cpt2, FASN, and ATP5b and decreased levels of GLUT2 and ACC1 to enhance glycolysis and inhibit lipid metabolism and TCA cycle.	Curcumin	13-21	acetyl-CoA carboxylase alpha	Rattus norvegicus	149-153
27099472-0	2016	Curcumin protects against myocardial infarction-induced cardiac fibrosis via SIRT1 activation in vivo and in vitro.	Curcumin	0-8	sirtuin 1	Mus musculus	77-82
27099472-6	2016	In addition, we found that the down-regulation of SIRT1 after MI was attenuated by curcumin pretreatment, which indicated that the activation of SIRT1 might be involved in the protective action of curcumin.	Curcumin	83-91	sirtuin 1	Mus musculus	50-55
27099472-6	2016	In addition, we found that the down-regulation of SIRT1 after MI was attenuated by curcumin pretreatment, which indicated that the activation of SIRT1 might be involved in the protective action of curcumin.	Curcumin	83-91	sirtuin 1	Mus musculus	145-150
35093937-0	2022	Correction for: Curcumin in combination with homoharringtonine suppresses lymphoma cell growth by inhibiting the TGF-beta/Smad3 signaling pathway.	Curcumin	16-24	SMAD family member 3	Homo sapiens	122-127
27099472-6	2016	In addition, we found that the down-regulation of SIRT1 after MI was attenuated by curcumin pretreatment, which indicated that the activation of SIRT1 might be involved in the protective action of curcumin.	Curcumin	197-205	sirtuin 1	Mus musculus	50-55
27099472-6	2016	In addition, we found that the down-regulation of SIRT1 after MI was attenuated by curcumin pretreatment, which indicated that the activation of SIRT1 might be involved in the protective action of curcumin.	Curcumin	197-205	sirtuin 1	Mus musculus	145-150
35078445-12	2022	In vitro, we further confirmed that curcumin significantly downregulated the expression of AURKA, CDK1, and TOP2A genes, while significantly upregulated the expression of CYP2B6, CYP2C9, and CYP3A4 genes.	Curcumin	36-44	aurora kinase A	Homo sapiens	91-96
26992258-0	2016	Curcumin Rescues Diabetic Renal Fibrosis by Targeting Superoxide-Mediated Wnt Signaling Pathways.	Curcumin	0-8	Wnt family member 2	Rattus norvegicus	74-77
26992258-1	2016	The purposes of this study were to investigate whether curcumin can weaken diabetic nephropathy by modulating both oxidative stress and renal injury from Wnt signaling mediation.	Curcumin	55-63	Wnt family member 2	Rattus norvegicus	154-157
26992258-3	2016	Curcumin resumes HG depression of Wnt/beta-catenin signaling and alleviates HG induction of superoxide, TGF-beta1 and fibronectin expression in renal mesangial cell.	Curcumin	0-8	Wnt family member 2	Rattus norvegicus	34-37
35078445-12	2022	In vitro, we further confirmed that curcumin significantly downregulated the expression of AURKA, CDK1, and TOP2A genes, while significantly upregulated the expression of CYP2B6, CYP2C9, and CYP3A4 genes.	Curcumin	36-44	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	171-177
35078445-13	2022	CONCLUSIONS: Our results provided a novel panel of AURKA, CDK1, TOP2A, CYP2C9, and CYP3A4 candidate genes for curcumin related chemotherapy of hepatocellular carcinoma.	Curcumin	110-118	aurora kinase A	Homo sapiens	51-56
35097276-4	2022	Strikingly, in the active form, myricetin binds to a new allosteric site (AS2) far away from the active site pocket and the allosteric site (AS1) for binding curcumin, while in the inactive form, it binds to both AS1 and AS2.	Curcumin	158-166	prostaglandin D2 receptor	Homo sapiens	141-144
26992258-3	2016	Curcumin resumes HG depression of Wnt/beta-catenin signaling and alleviates HG induction of superoxide, TGF-beta1 and fibronectin expression in renal mesangial cell.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	38-50
26992258-3	2016	Curcumin resumes HG depression of Wnt/beta-catenin signaling and alleviates HG induction of superoxide, TGF-beta1 and fibronectin expression in renal mesangial cell.	Curcumin	0-8	fibronectin 1	Rattus norvegicus	118-129
26833194-7	2016	Similarly, suppression of Mlh1 using ShRNA increased GADD45alpha upregulation upon curcumin treatment.	Curcumin	83-91	mutL homolog 1	Homo sapiens	26-30
26833194-8	2016	On the other hand, suppression of GADD45alpha using SiRNA-blocked curcumin-induced cell death induction in Mlh1-deficient cells.	Curcumin	66-74	mutL homolog 1	Homo sapiens	107-111
35097276-4	2022	Strikingly, in the active form, myricetin binds to a new allosteric site (AS2) far away from the active site pocket and the allosteric site (AS1) for binding curcumin, while in the inactive form, it binds to both AS1 and AS2.	Curcumin	158-166	prostaglandin D2 receptor	Homo sapiens	213-216
26915414-6	2016	Ingenuity Pathway Analysis(TM) (IPA) suggested that curcumin may exert its anticancer effects over multiple critical biological pathways including the EIF2, eIF4/p70S6K, mTOR signaling and mitochondrial dysfunction pathways.	Curcumin	52-60	ribosomal protein S6 kinase B1	Homo sapiens	162-168
35517894-0	2022	Curcumin Prevents Epithelial-to Mesenchymal Transition-Mediated Ovarian Cancer Progression through NRF2/ETBR/ET-1 Axis and Preserves Mitochondria Biogenesis in Kidney after Cisplatin Administration.	Curcumin	0-8	endothelin receptor type B	Rattus norvegicus	104-108
26796279-14	2016	Inhibition of NFkappaB activity as well as suppression of ROS generation with NAC resulted in the partial relief of cells from G2/M checkpoint after curcumin treatment in wt MCF-7 cells.	Curcumin	149-157	synuclein alpha	Homo sapiens	78-81
35517894-8	2022	The kidney phenotype in the ovarian cancer rat model after cisplatin +- curcumin administration will also be analyzed Results: Co-treatment of cisplatin with curcumin enhanced the expression of a gene involved in apoptosis in association with NRF2 enhancement, thus activated ETBR-mediated ET-1 clearance in SKOV3 cell and ovarian cancer model in rat.	Curcumin	158-166	endothelin receptor type B	Rattus norvegicus	276-280
35517894-9	2022	Moreover, curcumin treatment improved mitochondria biogenesis markers such as PGC-1alpha and TFAM and prevented the elevated of ET-1-mediated renal fibrosis and apoptosis in kidney isolated from cisplatin-treated ovarian cancer rat.	Curcumin	10-18	transcription factor A, mitochondrial	Rattus norvegicus	93-97
33934954-3	2021	The main databases were searched to identify eligible trials evaluating the effect of curcumin in reducing IL-1, IL-6, IL-8, and TNF-alpha in serum up to March 2021.	Curcumin	86-94	interleukin 1 alpha	Homo sapiens	107-111
26414021-9	2016	Curcumin also reduced the expression of Frizzled and beta-catenin, upregulated the expression of adipogenic transcription factors, and restored lipid content in HSCs.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	53-65
27297427-6	2016	When muscles from MW rats were incubated with curcumin in vitro, the calpain-, cathepsin L-, and proteasome-dependent muscle proteolysis were significantly decreased.	Curcumin	46-54	cathepsin L	Rattus norvegicus	79-90
26442630-7	2016	Interestingly, ATM/ATR activation by curcumin induced phosphorylation of Chk2 (Thr68) followed by that of Cdc25C (Ser216) and Cdc2 (Tyr15), and Cyclin B1 accumulation.	Curcumin	37-45	ATM serine/threonine kinase	Homo sapiens	15-18
26442630-7	2016	Interestingly, ATM/ATR activation by curcumin induced phosphorylation of Chk2 (Thr68) followed by that of Cdc25C (Ser216) and Cdc2 (Tyr15), and Cyclin B1 accumulation.	Curcumin	37-45	cell division cycle 25C	Homo sapiens	106-112
26442630-7	2016	Interestingly, ATM/ATR activation by curcumin induced phosphorylation of Chk2 (Thr68) followed by that of Cdc25C (Ser216) and Cdc2 (Tyr15), and Cyclin B1 accumulation.	Curcumin	37-45	cyclin dependent kinase 1	Homo sapiens	106-110
26442630-7	2016	Interestingly, ATM/ATR activation by curcumin induced phosphorylation of Chk2 (Thr68) followed by that of Cdc25C (Ser216) and Cdc2 (Tyr15), and Cyclin B1 accumulation.	Curcumin	37-45	cyclin B1	Homo sapiens	144-153
26588603-1	2015	The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors.	Curcumin	12-20	prostaglandin E synthase	Mus musculus	62-69
26588603-4	2015	In particular, the curcumin scaffold was modified with three types of substituents at positions C-1, C-8, and/or C-8" [C5 (isopentenyl, 5-8), C10 (geranyl, 9-12), and C15 (farnesyl, 13, 14)] in order to make these molecules more selective than the parent compound toward two specific targets: histone deacetylase (HDAC) and microsomal prostaglandin E2 synthase-1 (mPGES-1).	Curcumin	19-27	prostaglandin E synthase	Mus musculus	364-371
26588603-7	2015	We hypothesize about the covalent interaction of curcumin, 5, and 9 with the mPGES-1 binding site.	Curcumin	49-57	prostaglandin E synthase	Mus musculus	77-84
26884658-8	2015	Serum amyloid assay and lipid peroxidation were significantly lower, and myeloperoxidase assay was higher in the curcumin-treated group at the end of 24 h; thus, curcumin probably demonstrated a neutrophil-mediated immunopotentiation and anti-inflammatory action thereby protecting the animal from endotoxemia-induced multi-organ damage.	Curcumin	113-121	myeloperoxidase	Rattus norvegicus	73-88
26884838-6	2015	The further evidence showed that curcumin supplement significantly decreased the TRAP-positive stained area and inhibited the activity of OPG/RANKL/RANK signaling in the GIOP mice.	Curcumin	33-41	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	142-147
26498137-4	2015	Axl promoter activity was also reduced by curcumin, indicating that curcumin downregulates Axl expression at the transcriptional level.	Curcumin	68-76	AXL receptor tyrosine kinase	Homo sapiens	91-94
26498137-5	2015	Moreover, Axl phosphorylation in response to binding of its ligand, Gas6, was abrogated by curcumin, suggesting the inhibitory effect of curcumin on Gas6-induced Axl activation.	Curcumin	91-99	AXL receptor tyrosine kinase	Homo sapiens	10-13
26498137-5	2015	Moreover, Axl phosphorylation in response to binding of its ligand, Gas6, was abrogated by curcumin, suggesting the inhibitory effect of curcumin on Gas6-induced Axl activation.	Curcumin	91-99	growth arrest specific 6	Homo sapiens	68-72
26498137-5	2015	Moreover, Axl phosphorylation in response to binding of its ligand, Gas6, was abrogated by curcumin, suggesting the inhibitory effect of curcumin on Gas6-induced Axl activation.	Curcumin	91-99	growth arrest specific 6	Homo sapiens	149-153
26498137-5	2015	Moreover, Axl phosphorylation in response to binding of its ligand, Gas6, was abrogated by curcumin, suggesting the inhibitory effect of curcumin on Gas6-induced Axl activation.	Curcumin	91-99	AXL receptor tyrosine kinase	Homo sapiens	162-165
26498137-5	2015	Moreover, Axl phosphorylation in response to binding of its ligand, Gas6, was abrogated by curcumin, suggesting the inhibitory effect of curcumin on Gas6-induced Axl activation.	Curcumin	137-145	AXL receptor tyrosine kinase	Homo sapiens	10-13
26498137-5	2015	Moreover, Axl phosphorylation in response to binding of its ligand, Gas6, was abrogated by curcumin, suggesting the inhibitory effect of curcumin on Gas6-induced Axl activation.	Curcumin	137-145	growth arrest specific 6	Homo sapiens	68-72
26498137-5	2015	Moreover, Axl phosphorylation in response to binding of its ligand, Gas6, was abrogated by curcumin, suggesting the inhibitory effect of curcumin on Gas6-induced Axl activation.	Curcumin	137-145	growth arrest specific 6	Homo sapiens	149-153
26498137-5	2015	Moreover, Axl phosphorylation in response to binding of its ligand, Gas6, was abrogated by curcumin, suggesting the inhibitory effect of curcumin on Gas6-induced Axl activation.	Curcumin	137-145	AXL receptor tyrosine kinase	Homo sapiens	162-165
26498137-8	2015	It is further observed that the anti-proliferative effect of curcumin on A549 cells overexpressing Axl protein was reduced, while that on H460 cells transfected Axl specific siRNA was augmented, confirming that curcumin inhibits cell proliferation via downregulation of Axl expression.	Curcumin	61-69	AXL receptor tyrosine kinase	Homo sapiens	99-102
26498137-9	2015	In addition, curcumin was found to cause the induction of p21, a cyclin-dependent kinase inhibitor, and reduction of X-linked inhibitor of apoptosis protein (XIAP), an anti-apoptotic molecule, in parental H460 cells as well as chemoresistant cells, H460/CisR and H460/TR.	Curcumin	13-21	H3 histone pseudogene 16	Homo sapiens	58-61
26498137-10	2015	Taken together, our data imply that Axl RTK is a novel target of curcumin through which it exerts anti-proliferative effect in both parental and chemoresistant NSCLC cells.	Curcumin	65-73	AXL receptor tyrosine kinase	Homo sapiens	36-39
26498137-10	2015	Taken together, our data imply that Axl RTK is a novel target of curcumin through which it exerts anti-proliferative effect in both parental and chemoresistant NSCLC cells.	Curcumin	65-73	ret proto-oncogene	Homo sapiens	40-43
26547533-10	2015	Such significant improvement in cytotoxic activity and oral bioavailability of curcumin when formulated into mixed micelles could be attributed to solubilization of hydrophobic curcumin into micelle core along with P-gp inhibition effect of both, PF127 and GL44.	Curcumin	79-87	phosphoglycolate phosphatase	Homo sapiens	215-219
26250869-0	2015	Curcumin suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	20-25
26250869-3	2015	Here, we sought to investigate the role and mechanism of curcumin on the inhibition of mature IL-1beta production via the regulation of NLRP3 inflammasome.	Curcumin	57-65	NLR family, pyrin domain containing 3	Mus musculus	136-141
26250869-4	2015	METHODS AND RESULTS: Curcumin dramatically inhibited the production of mature IL-1beta in LPS-primed macrophages triggered by multiple NLRP3 inflammasome activators, and also reduced the level of cleaved caspase-1 as measured by western blot and ELISA.	Curcumin	21-29	NLR family, pyrin domain containing 3	Mus musculus	135-140
26250869-5	2015	Curcumin prevented K(+) efflux, the common trigger for NLRP3 inflammasome activation, and attenuated lysosomes disruption and intracellular ROS formation as well.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	55-60
25963235-12	2015	In addition, curcumin upregulated vitamin D receptor (VDR) expression in femurs of rats exposed to HLS and MC3T3-E1 cells exposed to modeled microgravity.	Curcumin	13-21	vitamin D receptor	Rattus norvegicus	34-52
25963235-12	2015	In addition, curcumin upregulated vitamin D receptor (VDR) expression in femurs of rats exposed to HLS and MC3T3-E1 cells exposed to modeled microgravity.	Curcumin	13-21	vitamin D receptor	Rattus norvegicus	54-57
25963235-13	2015	CONCLUSION: Curcumin alleviated HLS-induced bone loss in rats, possibly via suppressing oxidative stress and upregulating VDR expression.	Curcumin	12-20	vitamin D receptor	Rattus norvegicus	122-125
26515683-9	2015	Moreover, in vitro or in vivo treatment with curcumin, a natural phenolic compound, significantly enhanced CFTR expression and reversed the heat-induced increases in COX-2/PGE2/IL-8, neutrophil infiltration and tissue damage in the airway.	Curcumin	45-53	CF transmembrane conductance regulator	Rattus norvegicus	107-111
26515683-10	2015	These results have revealed a CFTR-regulated MAPK/NF-kappaB pathway leading to COX-2/PGE2/IL-8 activation in thermal inhalation injury, and demonstrated therapeutic potential of curcumin for alleviating heat-induced pulmonary inflammation.	Curcumin	178-186	CF transmembrane conductance regulator	Rattus norvegicus	30-34
26517556-5	2015	RESULTS: Curcumin treatment reduced the number of heterolysosomes and shifted their subcellular localization to the periphery, as revealed by electron microscopy, and stimulated the release of lysosomal beta-hexosaminidase and exosome markers flotillin-2 and CD63 into the media.	Curcumin	9-17	CD63 molecule	Homo sapiens	259-263
26439985-1	2015	The synthetic curcumin analog B5 is a potent inhibitor of thioredoxin reductase (TrxR) that has potential anticancer effects.	Curcumin	14-22	thioredoxin	Homo sapiens	58-69
26278015-5	2015	Furthermore, the present study also examined the effect of exercise and curcumin treatment on the levels of cAMP and downstream targets of PKA including phosphorylated CREB and LKB-1.	Curcumin	72-80	cAMP responsive element binding protein 1	Rattus norvegicus	168-172
26278015-11	2015	Furthermore, curcumin treatment as well as exercise also increased levels of cAMP and downstream target of PKA including phosphorylation CREB and LKB-1 which are involved in the regulation of mitochondrial biogenesis.	Curcumin	13-21	cAMP responsive element binding protein 1	Rattus norvegicus	137-141
26278015-11	2015	Furthermore, curcumin treatment as well as exercise also increased levels of cAMP and downstream target of PKA including phosphorylation CREB and LKB-1 which are involved in the regulation of mitochondrial biogenesis.	Curcumin	13-21	serine/threonine kinase 11	Rattus norvegicus	146-151
26677679-0	2015	[Effect of Curcumin on TGF-beta2 Regulated PPAR-gamma/PDGF-beta Signaling Pathway in Lung Fibroblasts of Mice].	Curcumin	11-19	platelet derived growth factor, B polypeptide	Mus musculus	54-63
26677679-1	2015	OBJECTIVE: To explore the effect of curcumin on TGF-beta2 regulated peroxisome proliferater activated receptor y (PPAR-gamma)/platelet derived growth factor beta (PDGF-beta) signaling pathway in lung fibroblasts of mice.	Curcumin	36-44	platelet derived growth factor, B polypeptide	Mus musculus	163-172
26305550-0	2015	Curcumin combined with FAPalphac vaccine elicits effective antitumor response by targeting indolamine-2,3-dioxygenase and inhibiting EMT induced by TNF-alpha in melanoma.	Curcumin	0-8	indoleamine 2,3-dioxygenase 1	Mus musculus	91-117
26321746-0	2015	Dendrosomal curcumin increases expression of the long non-coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer.	Curcumin	12-20	maternally expressed 3	Homo sapiens	74-78
26321746-7	2015	Bioactive nutrients including curcumin offer great potential in altering DNA methylation status which is catalyzed via DNMT1, DNMT3A and 3B.	Curcumin	30-38	DNA methyltransferase 3 alpha	Homo sapiens	126-139
25711190-5	2015	The levels of serum cytokines IL-10 and TNF-alpha were also significantly reduced after curcumin treatment, as evident from ELISA analysis.	Curcumin	88-96	interleukin 10	Rattus norvegicus	30-35
26617882-3	2015	METHODS: NASH model was established in rats, the protective effects of curcumin were evaluated by histological observation; structure and function assessments of mitochondria; and apoptotic genes expression.	Curcumin	71-79	SAM domain, SH3 domain and nuclear localization signals, 1	Rattus norvegicus	9-13
26617882-4	2015	RESULTS: NASH rats treated with curcumin displayed relatively slight liver damage when compared with NASH livers.	Curcumin	32-40	SAM domain, SH3 domain and nuclear localization signals, 1	Rattus norvegicus	9-13
26617882-5	2015	The average mitochondrial length and width of NASH (12.0 +- 3.2 and 5.1 +- 1.1 micrometers) were significantly longer than that of normal (6.2 +- 2.1 and 2.1 +- 1.5 micrometers) and NASH treated with curcumin (7.4 +- 1.2 and 3.2 +- 1.5 micrometers) rats.	Curcumin	200-208	SAM domain, SH3 domain and nuclear localization signals, 1	Rattus norvegicus	46-50
26366279-0	2015	Effect of curcumin on the interaction between androgen receptor and Wnt/beta-catenin in LNCaP xenografts.	Curcumin	10-18	catenin beta 1	Homo sapiens	72-84
26366279-2	2015	Our previous study showed that curcumin inhibits androgen receptor (AR) through modulation of Wnt/beta-catenin signaling in LNCaP cells.	Curcumin	31-39	catenin beta 1	Homo sapiens	98-110
26366279-9	2015	The mean prostate-specific antigen (PSA) doubling time in the curcumin group was approximately twice that in the untreated group.	Curcumin	62-70	kallikrein related peptidase 3	Homo sapiens	9-40
26366279-11	2015	The PSA levels tended to be reduced in the curcumin group.	Curcumin	43-51	kallikrein related peptidase 3	Homo sapiens	4-7
26366279-13	2015	CONCLUSIONS: This study revealed that curcumin initially interferes with prostate cancer growth by inhibiting AR activity and possibly by reducing PSA expression.	Curcumin	38-46	kallikrein related peptidase 3	Homo sapiens	147-150
26100249-0	2015	Curcumin inhibits human cytomegalovirus by downregulating heat shock protein 90.	Curcumin	0-8	heat shock protein 90 alpha family class A member 1	Homo sapiens	58-79
26100249-2	2015	The present study reported that the pharmacogenomics of curcumin are similar to that of the antiviral drug, geldanamycin, which targets heat shock protein 90 (Hsp90).	Curcumin	56-64	heat shock protein 90 alpha family class A member 1	Homo sapiens	136-157
26100249-2	2015	The present study reported that the pharmacogenomics of curcumin are similar to that of the antiviral drug, geldanamycin, which targets heat shock protein 90 (Hsp90).	Curcumin	56-64	heat shock protein 90 alpha family class A member 1	Homo sapiens	159-164
26100249-4	2015	Molecular docking simulation analysis revealed that curcumin fit well in the binding pocket of Hsp90, with hydrogen bonds, hydrophobic interactions and conjugation to maintain adhesion.	Curcumin	52-60	heat shock protein 90 alpha family class A member 1	Homo sapiens	95-100
26100249-5	2015	Consistently, HCMV infection of human embryonic lung fibroblast cells resulted in increased expression of Hsp90alpha, which was significantly inhibited by treatment with curcumin.	Curcumin	170-178	heat shock protein 90 alpha family class A member 1	Homo sapiens	106-116
26100249-6	2015	These findings suggested that targeting Hsp90 contributed to the anti-HCMV activity of curcumin.	Curcumin	87-95	heat shock protein 90 alpha family class A member 1	Homo sapiens	40-45
26827544-0	2015	[The effects of curcumin on PTEN/PI3K/Akt pathway in Ec109 cells].	Curcumin	16-24	phosphatase and tensin homolog	Homo sapiens	28-32
26827544-1	2015	OBJECTIVE: To investigate the inhibition effect of curcumin on the proliferation of the human esophageal carcinoma cell line Ec109 and its impact on PEN/PI3K/Akt signaling pathway.	Curcumin	51-59	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	149-152
26827544-4	2015	The protein levels of PTEN, Akt, GSK3P and Caspase 3 of curcumin-treated Ec109 cells were detected by Western blot.	Curcumin	56-64	phosphatase and tensin homolog	Homo sapiens	22-26
26827544-8	2015	On the other hand, curcumin could promote the expression of PTEN, GSK3beta and Caspase 3 yet reduce the expression of Akt.	Curcumin	19-27	phosphatase and tensin homolog	Homo sapiens	60-64
26827544-9	2015	CONCLUSION: Curcumin could obviously up-regulate the expression of PTEN, GSK3beta and Caspase 3, surpress PI3K/Akt signaling pathway and hence inhibit the proliferation of Ec109 cells.	Curcumin	12-20	phosphatase and tensin homolog	Homo sapiens	67-71
26071936-4	2015	We previously demonstrated that curcumin increased reactive oxygen species (ROS) formation and apoptosis in dermal fibroblasts, which could be prevented by pre-induction of the cytoprotective enzyme heme oxygenase (HO)-1.	Curcumin	32-40	heme oxygenase 1	Homo sapiens	199-220
26119880-0	2015	Curcumin attenuates brain edema in mice with intracerebral hemorrhage through inhibition of AQP4 and AQP9 expression.	Curcumin	0-8	aquaporin 9	Mus musculus	101-105
26119880-9	2015	Furthermore, curcumin dose-dependently decreased the gene and protein expression of AQP4 and AQP9, but not AQP1 post ICH.	Curcumin	13-21	aquaporin 9	Mus musculus	93-97
26119880-11	2015	CONCLUSION: Curcumin effectively attenuates brain edema in mice with ICH through inhibition of the NF-kappaB pathway and subsequently the expression of AQP4 and AQP9.	Curcumin	12-20	aquaporin 9	Mus musculus	161-165
25934542-6	2015	The curcumin effect was accompanied by significantly reduced expression of the NMD factors UPF1, 2, 3A and 3B.	Curcumin	4-12	UPF1 RNA helicase and ATPase	Homo sapiens	91-109
25934542-7	2015	Consistently, in chromatin immunoprecipitation assays, curcumin specifically reduced the occupancy of acetyl-histone H3 and RNA polymerase II at the promoter region (-376 to -247nt) of human UPF1, in a time- and dosage-dependent way.	Curcumin	55-63	UPF1 RNA helicase and ATPase	Homo sapiens	191-195
25934542-8	2015	Importantly, knocking down UPF1 abolished or substantially reduced the difference of PTC(+) transcript levels between control and curcumin-treated cells.	Curcumin	130-138	UPF1 RNA helicase and ATPase	Homo sapiens	27-31
25934542-9	2015	The disrupted curcumin effect was efficiently rescued by expression of exogenous Myc-UPF1 in the knockdown cells.	Curcumin	14-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	81-84
25934542-9	2015	The disrupted curcumin effect was efficiently rescued by expression of exogenous Myc-UPF1 in the knockdown cells.	Curcumin	14-22	UPF1 RNA helicase and ATPase	Homo sapiens	85-89
25882494-6	2015	In addition, we have observed that curcumin acts by interfering with PBX-1/MEIS-1, NF-kappaB and AP-1 complexes, in this work demonstrated for the first time to regulate the transcription of the PHOX2B gene.	Curcumin	35-43	PBX homeobox 1	Homo sapiens	69-74
26305715-7	2015	Moreover, curcumin alleviated the symptom of hyperlipidemia and hepatic steatosis via modulating the expression of sterol regulatory element-binding protein-1c, fatty acid synthase, and peroxisome proliferator-activated receptor-alpha as well as the activity of carnitine palmitoyltransferase 1.	Curcumin	10-18	peroxisome proliferator activated receptor alpha	Homo sapiens	186-234
25944087-5	2015	Leflunomide, a STAT6 inhibitor, and IL-4 and/or IL-13 neutralizing antibodies antagonized the induction of MMR, Arg-1 and PPAR-gamma by curcumin in Raw264.7 cells.	Curcumin	136-144	interleukin 4	Mus musculus	36-40
26154585-6	2015	Analyzed alpha-glucosidase activity reveals natural compound inhibitors (below 0.5 mM) are Curcumin, Actinodaphnine, 16-H, Quercetin, Berberine, and Catechin when compared to the commercial drug Acarbose (3 mM).	Curcumin	91-99	sucrase-isomaltase	Homo sapiens	9-26
25945832-6	2015	Trx1 inhibition by PX-12 sensitized MM cells to undergo apoptosis in response to the NF-kappabeta inhibitors, BAY 11-7082 and curcumin.	Curcumin	126-134	thioredoxin	Homo sapiens	0-4
26035833-3	2015	We discovered that curcumin diet intervention significantly improved gait impairments and resulted in an increase in phosphorylated forms of alpha-synuclein at cortical presynaptic terminals.	Curcumin	19-27	synuclein, alpha	Mus musculus	141-156
26035833-4	2015	Acute curcumin treatment also caused an increase in phosphorylated alpha-synuclein in terminals, but had no direct effect on alpha-synuclein aggregation, as measured by in vivo multiphoton imaging and Proteinase-K digestion.	Curcumin	6-14	synuclein, alpha	Mus musculus	67-82
25755051-0	2015	Curcumin induces apoptotic cell death via Oct4 inhibition and GSK-3beta activation in NCCIT cells.	Curcumin	0-8	POU class 5 homeobox 1	Homo sapiens	42-46
25988362-6	2015	Furthermore, such a curcumin treatment reduced CFA-induced activation of glial cells and production of inflammatory mediators [interleukin-1beta (IL-1beta), monocyte chemoattractant protein-1 (MCP-1), and monocyte inflammatory protein-1 (MIP-1alpha)] in the spinal cord.	Curcumin	20-28	C-C motif chemokine ligand 2	Rattus norvegicus	157-191
25988362-6	2015	Furthermore, such a curcumin treatment reduced CFA-induced activation of glial cells and production of inflammatory mediators [interleukin-1beta (IL-1beta), monocyte chemoattractant protein-1 (MCP-1), and monocyte inflammatory protein-1 (MIP-1alpha)] in the spinal cord.	Curcumin	20-28	C-C motif chemokine ligand 2	Rattus norvegicus	193-198
25988362-7	2015	Curcumin also decreased lipopolysaccharide-induced production of IL-1beta, tumor necrosis factor-alpha, MCP-1, and MIP-1alpha in cultured astrocytes and microglia.	Curcumin	0-8	C-C motif chemokine ligand 2	Rattus norvegicus	104-109
25985292-0	2015	Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant alpha-Synuclein.	Curcumin	0-8	synuclein alpha	Homo sapiens	156-171
25985292-8	2015	These two analogues of curcumin described here may therefore be useful therapeutic inhibitors for the treatment of alpha-synuclein amyloidosis and toxicity in Parkinson"s disease and other synucleinopathies.	Curcumin	23-31	synuclein alpha	Homo sapiens	115-130
25961579-8	2015	Curcumin also strongly inhibited the expression of gp130, a critical molecule in IL-6 signaling, whereas expression of IL-6R and sIL-6R was not affected.	Curcumin	0-8	interleukin 6 cytokine family signal transducer	Homo sapiens	51-56
26097529-0	2015	Anti-inflammatory and antioxidant effects of curcumin on acute lung injury in a rodent model of intestinal ischemia reperfusion by inhibiting the pathway of NF-Kb.	Curcumin	45-53	nuclear factor kappa B subunit 1	Rattus norvegicus	157-162
26020187-8	2015	Curcumin supplementation (50, 100, and 200 mg/kg) increased (P &lt; 0.05) mitochondrial glutathione content and glutathione peroxidase, glutathione S-transferase, and manganese superoxide dismutase activities compared to heat-stressed broilers.	Curcumin	0-8	glutathione S-transferase kappa 1	Homo sapiens	136-161
25526295-1	2015	In order to improve curcumin"s low water-solubility and selective delivery to cancer, we reported ligand-mediated micelles based on a Y-shaped biotin-poly (ethylene glycol)-poly (epsilon-caprolactone)2 (biotin-PEG-PCL2) copolymer.	Curcumin	20-28	metal response element binding transcription factor 2	Homo sapiens	214-218
24926560-7	2015	The results indicate that curcumin increased the cell surface expression of CD35 (secretory vesicle), CD63 (azurophilic granules), and CD66b (gelatinase granules) in neutrophils.	Curcumin	26-34	CD63 molecule	Homo sapiens	102-106
25676631-7	2015	SULT1B1 is only responsible for sulfonation of curcumin.	Curcumin	47-55	sulfotransferase family 1B member 1	Homo sapiens	0-7
25822711-4	2015	Curcumin sustained the LIF independent self-renewal of mESCs and induced pluripotent stem cells (miPSCs) in a STAT3 activity dependent manner.	Curcumin	0-8	leukemia inhibitory factor	Mus musculus	23-26
25371072-14	2015	On the other hand, the curcumin-treated group showed a significant depletion in the studied tumor markers and a significant downregulation in GGT and HSPgp96 gene expression.	Curcumin	23-31	gamma-glutamyltransferase 1	Rattus norvegicus	142-145
26248429-10	2015	The data of FCM showed that curcumin could increase the expression of PTEN, GSK3beta and Caspase 3, decreased the expression of AKT.	Curcumin	28-36	phosphatase and tensin homolog	Homo sapiens	70-74
26248429-11	2015	CONCLUSION: The effects of curcumin on inhibiting proliferation and promoting apoptosis of EC109 cells were related with increased expression of PTEN and inhibition of PI3K/AKT signaling pathway.	Curcumin	27-35	phosphatase and tensin homolog	Homo sapiens	145-149
25499851-7	2015	MnSOD-mediated cisplatin resistance can be overcome by a Bcl-2 antagonist (ABT-199) or IKKbeta inhibitor (curcumin) in cells and xenograft tumors.	Curcumin	106-114	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	87-94
28962370-0	2015	Curcumin protects rat liver from streptozotocin-induced diabetic pathophysiology by counteracting reactive oxygen species and inhibiting the activation of p53 and MAPKs mediated stress response pathways.	Curcumin	0-8	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	155-158
26412696-3	2015	The activity of liver GST toward a universal substrate, CDNB, was increased in curcumin-administered rats.	Curcumin	79-87	hematopoietic prostaglandin D synthase	Rattus norvegicus	22-25
26412696-6	2015	Moreover, we have observed that curcumin also reduced glutathione S-transferase placental form positive single cells and foci caused by AFB1 treatment.	Curcumin	32-40	hematopoietic prostaglandin D synthase	Rattus norvegicus	54-79
25998190-0	2015	Curcumin Modulates Macrophage Polarization Through the Inhibition of the Toll-Like Receptor 4 Expression and its Signaling Pathways.	Curcumin	0-8	toll like receptor 4	Homo sapiens	73-93
25998190-13	2015	CONCLUSIONS: Curcumin can modulate macrophage polarization through TLR4-mediated signaling pathway inhibition, indicating that its effect on macrophage polarization is related to its anti-inflammatory and atheroprotective effects.	Curcumin	13-21	toll like receptor 4	Homo sapiens	67-71
26539236-4	2015	Furthermore, the experiments in vitro and in vivo both displayed that curcumin could downregulate the mRNA and protein expressions of Wnt1, Wnt2b, Wnt6, and beta-catenin and upregulate the phosphorylation level of beta-catenin protein in podocytes and renal tissue.	Curcumin	70-78	wingless-type MMTV integration site family, member 2B	Mus musculus	140-145
26216111-9	2015	One potential mechanism to explain several of the general health benefits associated with curcumin is that it may prevent ageing-associated changes in cellular proteins that lead to protein insolubility and aggregation after ischemia such as beta-amyloid peptide and tau protein.	Curcumin	90-98	microtubule associated protein tau	Homo sapiens	267-270
25262359-9	2015	Curcumin stimulated the expression of pro-apoptotic Bax, and inhibited the activation of anti-apoptotic Mcl-1 and Bcl-2.	Curcumin	0-8	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	104-109
26074974-7	2015	Curcumin pretreatment significantly increased cell viability and VEGF secretion, and decreased cell injury and apoptosis via regulation of PTEN/Akt/p53 and HO-1 signal proteins expression.	Curcumin	0-8	vascular endothelial growth factor A	Rattus norvegicus	65-69
26074974-7	2015	Curcumin pretreatment significantly increased cell viability and VEGF secretion, and decreased cell injury and apoptosis via regulation of PTEN/Akt/p53 and HO-1 signal proteins expression.	Curcumin	0-8	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	148-151
26074974-9	2015	Transplantation of curcumin pretreated ADSCs not only resulted in better heart function, higher cells retention, and smaller infarct size, but also decreased myocardial apoptosis, promoted neovascularization, and increased VEGF level in ischemic myocardium.	Curcumin	19-27	vascular endothelial growth factor A	Rattus norvegicus	223-227
25866478-0	2014	Curcumin inhibits leptin gene expression and secretion in breast cancer cells by estrogen receptors.	Curcumin	0-8	leptin	Homo sapiens	18-24
25866478-5	2014	Based on the fact that targeting of leptin could be considered as a novel strategy for breast cancer therapy, the aim of this study is the investigation of potentiality of curcumin for inhibition of leptin gene expression and secretion, and also, its link with expression of estrogen receptors.	Curcumin	172-180	leptin	Homo sapiens	199-205
25866478-13	2014	CONCLUSION: Based on the results, curcumin inhibits the expression and secretion of leptin and it could probably be used as a drug candidate for the breast cancer therapy through the leptin targeting in the future.	Curcumin	34-42	leptin	Homo sapiens	84-90
25866478-13	2014	CONCLUSION: Based on the results, curcumin inhibits the expression and secretion of leptin and it could probably be used as a drug candidate for the breast cancer therapy through the leptin targeting in the future.	Curcumin	34-42	leptin	Homo sapiens	183-189
25033705-8	2014	Furthermore, cells in the IWR1-treated group showed decreased wnt3a and beta-catenin expression, and wnt3a and beta-catenin was also decreased in the IWR1 + 500 nmol/L curcumin group.	Curcumin	168-176	catenin beta 1	Rattus norvegicus	111-123
25310360-5	2014	In the present study, we investigated the effect of curcumin on P19-induced apoptosis in human macrophage cells and the underlying mechanisms.	Curcumin	52-60	interleukin 23 subunit alpha	Homo sapiens	64-67
25310360-7	2014	A low dose of curcumin (10 or 20 microM) attenuated both the macrophage cell growth inhibition and the increase in the expression of IL-6 and TNF-alpha induced by P19.	Curcumin	14-22	interleukin 23 subunit alpha	Homo sapiens	163-166
25310360-8	2014	Curcumin also decreased the phosphorylation of JNK and p38 that were induced by P19.	Curcumin	0-8	interleukin 23 subunit alpha	Homo sapiens	80-83
25310360-10	2014	These data suggest that curcumin may protect macrophages from P19-induced cell apoptosis via a TLR2-mediated JNK-dependent pathway.	Curcumin	24-32	interleukin 23 subunit alpha	Homo sapiens	62-65
25450696-2	2014	In the present study, we investigated the effects of curcumin on the miR-9 expression in oral squamous cell carcinoma (OSCC) and explored the potential relationships between miR-9 and Wnt/beta-catenin pathway in curcumin-mediated OSCC inhibition in vitro.	Curcumin	212-220	catenin beta 1	Homo sapiens	188-200
25450696-4	2014	Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/beta-catenin signaling by increasing the expression levels of the GSK-3beta, phosphorylated GSK-3beta and beta-catenin, and decreasing the cyclin D1 level.	Curcumin	40-48	catenin beta 1	Homo sapiens	158-170
25450696-4	2014	Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/beta-catenin signaling by increasing the expression levels of the GSK-3beta, phosphorylated GSK-3beta and beta-catenin, and decreasing the cyclin D1 level.	Curcumin	40-48	catenin beta 1	Homo sapiens	264-276
25450696-6	2014	Downregulation of miR-9 by anti-miR-9 not only attenuated the growth-suppressive effects of curcumin on SCC-9 cells, but also re-activated Wnt/beta-catenin signaling that was inhibited by curcumin.	Curcumin	188-196	catenin beta 1	Homo sapiens	143-155
25116856-8	2014	Coincidentally, TrxR inhibitors such as curcumin and gold compounds exhibit potent osteoclastogenesis inhibitory activity.	Curcumin	40-48	peroxiredoxin 5	Homo sapiens	16-20
25175917-9	2014	Like curcumin, DEC prevents NF-kappaB activation by reducing NF-kappaB p65 phosphorylation and IkappaBalpha degradation.	Curcumin	5-13	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	71-74
24975470-7	2014	Curcumin reduced OGD/R-induced accumulation of reactive oxygen species and inhibited the mitochondrial apoptosis pathway, as indicated by reduced release of cytochrome c and apoptosis-inducing factor and maintenance of both the mitochondrial membrane potential and the Bax/Bcl-2 ratio.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	269-272
24945564-0	2014	Curcumin affects beta-catenin pathway in hepatic stellate cell in vitro and in vivo.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	17-29
24945564-4	2014	This study is aimed to examine whether curcumin affects beta-catenin expression/activity in HSCs and explores the underlying mechanisms.	Curcumin	39-47	catenin beta 1	Rattus norvegicus	56-68
24945564-6	2014	KEY FINDINGS: Results showed that curcumin could reduce beta-catenin protein level in HSCs in vitro and in vivo.	Curcumin	34-42	catenin beta 1	Rattus norvegicus	56-68
24945564-7	2014	Both beta-catenin transactivation activity and DNA-binding activity were suppressed by curcumin.	Curcumin	87-95	catenin beta 1	Rattus norvegicus	5-17
24945564-8	2014	Moreover, nuclear beta-catenin protein level was decreased by curcumin treatment.	Curcumin	62-70	catenin beta 1	Rattus norvegicus	18-30
24945564-9	2014	Further experiments suggested that delta-like homologue 1 contributed to curcumin inhibition of beta-catenin transactivation activity in cultured HSCs.	Curcumin	73-81	catenin beta 1	Rattus norvegicus	96-108
24945564-10	2014	CONCLUSIONS: Curcumin affects beta-catenin pathway in HSCs and might suggest a possible new explanation for the effects of curcumin on HSC activation and liver fibrosis.	Curcumin	13-21	catenin beta 1	Rattus norvegicus	30-42
24945564-10	2014	CONCLUSIONS: Curcumin affects beta-catenin pathway in HSCs and might suggest a possible new explanation for the effects of curcumin on HSC activation and liver fibrosis.	Curcumin	123-131	catenin beta 1	Rattus norvegicus	30-42
25164566-0	2014	Curcumin enhances cell-surface LDLR level and promotes LDL uptake through downregulation of PCSK9 gene expression in HepG2 cells.	Curcumin	0-8	low density lipoprotein receptor	Homo sapiens	31-35
25164566-0	2014	Curcumin enhances cell-surface LDLR level and promotes LDL uptake through downregulation of PCSK9 gene expression in HepG2 cells.	Curcumin	0-8	proprotein convertase subtilisin/kexin type 9	Homo sapiens	92-97
25164566-3	2014	METHODS AND RESULTS: We found that curcumin enhanced LDL receptor (LDLR) level on the cell surface, as well as LDLR activity; however, LDLR transcription and mRNA stability were not affected.	Curcumin	35-43	low density lipoprotein receptor	Homo sapiens	53-65
25164566-3	2014	METHODS AND RESULTS: We found that curcumin enhanced LDL receptor (LDLR) level on the cell surface, as well as LDLR activity; however, LDLR transcription and mRNA stability were not affected.	Curcumin	35-43	low density lipoprotein receptor	Homo sapiens	67-71
25164566-3	2014	METHODS AND RESULTS: We found that curcumin enhanced LDL receptor (LDLR) level on the cell surface, as well as LDLR activity; however, LDLR transcription and mRNA stability were not affected.	Curcumin	35-43	low density lipoprotein receptor	Homo sapiens	111-115
25164566-3	2014	METHODS AND RESULTS: We found that curcumin enhanced LDL receptor (LDLR) level on the cell surface, as well as LDLR activity; however, LDLR transcription and mRNA stability were not affected.	Curcumin	35-43	low density lipoprotein receptor	Homo sapiens	111-115
25164566-4	2014	Furthermore, we found that proprotein convertase subtilisin/kexin type 9 (PCSK9) gene was downregulated at the transcriptional level by curcumin, leading to an increase in LDL uptake in HepG2 cells.	Curcumin	136-144	proprotein convertase subtilisin/kexin type 9	Homo sapiens	27-72
25164566-4	2014	Furthermore, we found that proprotein convertase subtilisin/kexin type 9 (PCSK9) gene was downregulated at the transcriptional level by curcumin, leading to an increase in LDL uptake in HepG2 cells.	Curcumin	136-144	proprotein convertase subtilisin/kexin type 9	Homo sapiens	74-79
25164566-5	2014	The curcumin-responsive element of the PCSK9 promoter, a binding site for hepatocyte nuclear factor 1alpha (HNF-1alpha), was also identified.	Curcumin	4-12	proprotein convertase subtilisin/kexin type 9	Homo sapiens	39-44
25164566-6	2014	We demonstrated that curcumin reduced the nuclear abundance of hepatocyte nuclear factor 1alpha, resulting in its attenuated interaction with the PCSK9 promoter and leading to a downregulation of PCSK9 expression.	Curcumin	21-29	proprotein convertase subtilisin/kexin type 9	Homo sapiens	146-151
25164566-6	2014	We demonstrated that curcumin reduced the nuclear abundance of hepatocyte nuclear factor 1alpha, resulting in its attenuated interaction with the PCSK9 promoter and leading to a downregulation of PCSK9 expression.	Curcumin	21-29	proprotein convertase subtilisin/kexin type 9	Homo sapiens	196-201
25164566-7	2014	Finally, we showed that curcumin decreased the statin-induced PCSK9 expression and potentially synergized with statin administration.	Curcumin	24-32	proprotein convertase subtilisin/kexin type 9	Homo sapiens	62-67
25164566-8	2014	CONCLUSION: Current results indicate that curcumin suppression of PCSK9 expression is associated with increases in cell-surface LDLR and LDLR activity in hepatic cells and it acts in a molecular mechanism that is distinct from the statins.	Curcumin	42-50	proprotein convertase subtilisin/kexin type 9	Homo sapiens	66-71
25164566-8	2014	CONCLUSION: Current results indicate that curcumin suppression of PCSK9 expression is associated with increases in cell-surface LDLR and LDLR activity in hepatic cells and it acts in a molecular mechanism that is distinct from the statins.	Curcumin	42-50	low density lipoprotein receptor	Homo sapiens	128-132
25164566-8	2014	CONCLUSION: Current results indicate that curcumin suppression of PCSK9 expression is associated with increases in cell-surface LDLR and LDLR activity in hepatic cells and it acts in a molecular mechanism that is distinct from the statins.	Curcumin	42-50	low density lipoprotein receptor	Homo sapiens	137-141
25041840-0	2014	Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice.	Curcumin	53-61	mechanistic target of rapamycin kinase	Mus musculus	27-31
25041840-0	2014	Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice.	Curcumin	53-61	presenilin 1	Mus musculus	87-90
25041840-5	2014	Curcumin, a nature plant extraction, has been reported to inhibit the generation and deposition of Abeta; however, the underlying mechanisms are not fully understood yet.	Curcumin	0-8	amyloid beta (A4) precursor protein	Mus musculus	99-104
25041840-6	2014	In the present study, we reported that curcumin treatment not only attenuated cognitive impairment detected by Morris water maze test, but also inhibited the generation of Abeta investigated by immunohistochemistry in APP/PS1 double transgenic AD mice.	Curcumin	39-47	amyloid beta (A4) precursor protein	Mus musculus	172-177
25456852-5	2014	And we investigated the effect of curcumin on HG-induced phosphorylation of cav-1 on the stability cav-1 and beta-catenin using immunoprecipitation and fluorescence microscopy analysis.	Curcumin	34-42	catenin beta 1	Rattus norvegicus	109-121
24938356-0	2014	Curcumin suppresses proliferation and invasion in non-small cell lung cancer by modulation of MTA1-mediated Wnt/beta-catenin pathway.	Curcumin	0-8	catenin beta 1	Homo sapiens	112-124
24938356-7	2014	Further research on the subsequent mechanism showed that curcumin inhibited the proliferation and invasion of NSCLC cells through MTA1-mediated inactivation of Wnt/beta-catenin pathway.	Curcumin	57-65	catenin beta 1	Homo sapiens	164-176
25027711-6	2014	TPA-induced phosphorylation of Akt, S6 kinase (S6K), and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) in mouse skin was lower in the curcumin group than in the control group.	Curcumin	158-166	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	98-118
25027711-6	2014	TPA-induced phosphorylation of Akt, S6 kinase (S6K), and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) in mouse skin was lower in the curcumin group than in the control group.	Curcumin	158-166	eukaryotic translation initiation factor 4E binding protein 1	Mus musculus	120-125
25064633-0	2014	Curcumin inhibits monocyte chemoattractant protein-1 expression and enhances cholesterol efflux by suppressing the c-Jun N-terminal kinase pathway in macrophage.	Curcumin	0-8	C-C motif chemokine ligand 2	Homo sapiens	18-52
25064633-1	2014	OBJECTIVE: To investigate the effect of curcumin on monocyte chemoattractant protein 1 (MCP-1) production and reverse cholesterol transport (RCT) in macrophage induced by oxidation low-density lipoprotein (ox-LDL), and to identify the signal pathways involved.	Curcumin	40-48	C-C motif chemokine ligand 2	Homo sapiens	52-86
25064633-1	2014	OBJECTIVE: To investigate the effect of curcumin on monocyte chemoattractant protein 1 (MCP-1) production and reverse cholesterol transport (RCT) in macrophage induced by oxidation low-density lipoprotein (ox-LDL), and to identify the signal pathways involved.	Curcumin	40-48	C-C motif chemokine ligand 2	Homo sapiens	88-93
25064633-6	2014	RESULTS: Curcumin decreased the production of MCP-1 induced by ox-LDL in macrophages.	Curcumin	9-17	C-C motif chemokine ligand 2	Homo sapiens	46-51
25064633-11	2014	CONCLUSION: Curcumin suppresses MCP-1 production induced by ox-LDL via the JNK pathway and NK-kappaB pathway, while enhances cholesterol efflux in macrophage via suppressing the JNK pathway and activating the LXR-ABCA1/SR-BI pathway, which indicate that the vascular protective effect of curcumin is related to anti-inflammation and anti-atherosclerosis.	Curcumin	12-20	C-C motif chemokine ligand 2	Homo sapiens	32-37
24831732-0	2014	Curcumin modulates miR-19/PTEN/AKT/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferation.	Curcumin	0-8	phosphatase and tensin homolog	Homo sapiens	26-30
24831732-8	2014	These results suggest for the first time that curcumin modulates miR-19/PTEN/AKT/p53 axis to exhibit its protective effects against BPA-associated breast cancer promotion.	Curcumin	46-54	phosphatase and tensin homolog	Homo sapiens	72-76
25612452-0	2014	[Neuroprotective effect of curcumin to Abeta of double transgenic mice with Alzheimer"s disease].	Curcumin	27-35	amyloid beta (A4) precursor protein	Mus musculus	39-44
25612452-8	2014	Whether curcumin can impact Abeta cascade reaction by down-regulating expressions of Abeta40, Abeta42 and ADDLs and show the neuroprotective effect needs further studies.	Curcumin	8-16	amyloid beta (A4) precursor protein	Mus musculus	28-33
25268357-0	2014	Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: a novel curcumin analog.	Curcumin	84-92	GS homeobox 2	Homo sapiens	63-74
25268357-2	2014	Here, we have assessed the therapeutic effects of a novel and water soluble curcumin analog, 3,5-bis(2-hydroxybenzylidene)tetrahydro-4H-pyran-4-one glutathione conjugate [EF25-(GSH)2], on hepatoma cells.	Curcumin	76-84	GS homeobox 2	Homo sapiens	171-182
25268357-9	2014	Taken together, these data imply a fail-safe mechanism regulated by autophagy in the action of EF25-(GSH)2, suggesting the therapeutic potential of the novel curcumin analog against hepatocellular carcinoma (HCC), while offering a novel and effective combination strategy with chloroquine for the treatment of patients with HCC.	Curcumin	158-166	GS homeobox 2	Homo sapiens	95-106
25229239-12	2014	It was found that curcumin attenuated AKT activation and the up-regulation of C/EBPbeta and miR-31 caused by EGF stimulation in OSCC cells.	Curcumin	18-26	microRNA 31	Homo sapiens	92-98
25198898-0	2014	Curcumin induced human gastric cancer BGC-823 cells apoptosis by ROS-mediated ASK1-MKK4-JNK stress signaling pathway.	Curcumin	0-8	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	78-82
25198898-4	2014	Inhibition of ROS generation by antioxidant (NAC or Trion) significantly prevented curcumin-mediated apoptosis.	Curcumin	83-91	synuclein alpha	Homo sapiens	45-48
25198898-5	2014	Notably, we observed that curcumin activated ASK1, a MAPKKK that is oxidative stress sensitive and responsible to phosphorylation of JNK via triggering cascades, up-regulated an upstream effector of the JNK, MKK4, and phosphorylated JNK protein expression in BGC-823 cells.	Curcumin	26-34	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	45-49
25198898-5	2014	Notably, we observed that curcumin activated ASK1, a MAPKKK that is oxidative stress sensitive and responsible to phosphorylation of JNK via triggering cascades, up-regulated an upstream effector of the JNK, MKK4, and phosphorylated JNK protein expression in BGC-823 cells.	Curcumin	26-34	mitogen-activated protein kinase kinase kinase 4	Homo sapiens	53-59
25198898-6	2014	However, curcumin induced ASK1-MKK4-JNK signaling was attenuated by NAC.	Curcumin	9-17	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	26-30
25198898-6	2014	However, curcumin induced ASK1-MKK4-JNK signaling was attenuated by NAC.	Curcumin	9-17	synuclein alpha	Homo sapiens	68-71
25198898-7	2014	All the findings confirm the possibility that oxidative stress-activated ASK1-MKK4-JNK signaling cascade promotes the apoptotic response in curcumin-treated BGC-823 cells.	Curcumin	140-148	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	73-77
27122821-7	2014	Curcumin-treated cardiac fibroblasts down-regulated phosphorylated protein kinase B (Akt) and phosphorylated Smad2/3 expression irrespective of TGF-beta1 treatment.	Curcumin	0-8	SMAD family member 2	Rattus norvegicus	109-114
27122821-9	2014	CONCLUSIONS: Curcumin attenuated Akt, Smad2/3, and ERK1/2 phosphorylation which were mediated by TGF-beta1 and angiotensin II.	Curcumin	13-21	SMAD family member 2	Rattus norvegicus	38-45
24486718-0	2014	Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression.	Curcumin	0-8	flap structure-specific endonuclease 1	Homo sapiens	96-100
24486718-5	2014	However, whether curcumin-induced inhibition of breast cancer cell proliferation may involve Nrf2-mediated Fen1 expression is not yet understood.	Curcumin	17-25	flap structure-specific endonuclease 1	Homo sapiens	107-111
24486718-6	2014	In this study, we demonstrated that curcumin inhibited Fen1-dependent proliferation of MCF-7 cells and significantly induced Nrf2 protein expression while inhibiting Fen1 protein expression.	Curcumin	36-44	flap structure-specific endonuclease 1	Homo sapiens	55-59
24486718-6	2014	In this study, we demonstrated that curcumin inhibited Fen1-dependent proliferation of MCF-7 cells and significantly induced Nrf2 protein expression while inhibiting Fen1 protein expression.	Curcumin	36-44	flap structure-specific endonuclease 1	Homo sapiens	166-170
24486718-7	2014	Curcumin could down-regulate Fen1 gene expression in a Nrf2-dependent manner.	Curcumin	0-8	flap structure-specific endonuclease 1	Homo sapiens	29-33
24486718-8	2014	Further investigation revealed that curcumin could lead to Nrf2 translocation from the cytoplasm to the nucleus and decrease Fen1 promoter activity by decreasing the recruitment of Nrf2 to the Fen1 promoter.	Curcumin	36-44	flap structure-specific endonuclease 1	Homo sapiens	125-129
24486718-8	2014	Further investigation revealed that curcumin could lead to Nrf2 translocation from the cytoplasm to the nucleus and decrease Fen1 promoter activity by decreasing the recruitment of Nrf2 to the Fen1 promoter.	Curcumin	36-44	flap structure-specific endonuclease 1	Homo sapiens	193-197
24486718-9	2014	These data suggest that curcumin may inhibit the proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression, which may be a new mechanism of curcumin-induced tumor growth inhibition.	Curcumin	24-32	flap structure-specific endonuclease 1	Homo sapiens	127-131
24486718-9	2014	These data suggest that curcumin may inhibit the proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression, which may be a new mechanism of curcumin-induced tumor growth inhibition.	Curcumin	176-184	flap structure-specific endonuclease 1	Homo sapiens	127-131
25136316-7	2014	In addition, curcumin with its versatile activities modulated the expression of many oxidative stress-regulating genes such as PDGF, VEGF, IGFBP-2, HO1, SOD2, and GPX1.	Curcumin	13-21	heme oxygenase 1	Homo sapiens	148-151
24920381-0	2014	SAR studies on curcumin"s pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.	Curcumin	15-23	sarcosinemia autosomal recessive	Mus musculus	0-3
24920381-5	2014	The strict structural requirements for mPGES-1 and 5-LO inhibition strongly suggest that specific interactions rather than redox or membrane effects underlie the inhibition of mPGES-1 and 5-LO by curcumin.	Curcumin	196-204	prostaglandin E synthase	Mus musculus	39-52
24920381-5	2014	The strict structural requirements for mPGES-1 and 5-LO inhibition strongly suggest that specific interactions rather than redox or membrane effects underlie the inhibition of mPGES-1 and 5-LO by curcumin.	Curcumin	196-204	prostaglandin E synthase	Mus musculus	176-189
24933427-0	2014	beta-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: a case study with alpha-synuclein.	Curcumin	22-30	synuclein alpha	Homo sapiens	115-130
24604727-6	2014	By regulating multiple important cellular signalling pathways including NF-kappaB, TRAIL, PI3 K/Akt, JAK/STAT, Notch-1, JNK, etc., curcumin are known to activate cell death signals and induce apoptosis in pre-cancerous or cancer cells without affecting normal cells, thereby inhibiting tumor progression.	Curcumin	131-139	TNF superfamily member 10	Felis catus	83-88
24858998-0	2014	Curcumin suppresses cell proliferation through inhibition of the Wnt/beta-catenin signaling pathway in medulloblastoma.	Curcumin	0-8	catenin beta 1	Homo sapiens	69-81
24858998-2	2014	The aim of the present study was to investigate the anticancer effects of curcumin on medulloblastoma cells by testing its capacity to suppress proliferation and regulate the Wnt/beta-catenin pathway.	Curcumin	74-82	catenin beta 1	Homo sapiens	179-191
24858998-8	2014	Furthermore, curcumin treatment led to activation of GSK-3beta, reduced expression of beta-catenin and its downstream target cyclin D1.	Curcumin	13-21	catenin beta 1	Homo sapiens	86-98
24858998-10	2014	In conclusion, curcumin can inhibit cell growth by suppressing the Wnt/beta-catenin signaling pathway, and it has the potential to be developed as a therapeutic agent for medulloblastoma.	Curcumin	15-23	catenin beta 1	Homo sapiens	71-83
24668280-6	2014	We also observed curcumin to impair cell survival by promoting apoptosis, evidenced by chromatin condensation, poly(ADP-ribose) polymerase (PARP) and caspase-3 cleavage, as well as Bax translocation and cytochrome c release into the cytosol.	Curcumin	17-25	poly (ADP-ribose) polymerase 1	Rattus norvegicus	111-138
24668280-6	2014	We also observed curcumin to impair cell survival by promoting apoptosis, evidenced by chromatin condensation, poly(ADP-ribose) polymerase (PARP) and caspase-3 cleavage, as well as Bax translocation and cytochrome c release into the cytosol.	Curcumin	17-25	poly (ADP-ribose) polymerase 1	Rattus norvegicus	140-144
24668280-7	2014	Curcumin-induced apoptosis was ascribed to JNKs, since hindering their activity abolished PARP fragmentation.	Curcumin	0-8	poly (ADP-ribose) polymerase 1	Rattus norvegicus	90-94
24668280-8	2014	Furthermore, we identified curcumin to exert a pro-oxidative activity, with 2",7"-dichlorofluorescin diacetate (DCFH-DA) staining revealing up-regulation of reactive oxygen species (ROS) levels and anti-oxidants found to abrogate PARP cleavage.	Curcumin	27-35	poly (ADP-ribose) polymerase 1	Rattus norvegicus	230-234
24675438-6	2014	Curcumin also increased the levels of anti-inflammatory cytokine i.e. IL-10 and antioxidant enzymes i.e. superoxide dismutase, catalase and glutathione peroxidase.	Curcumin	0-8	interleukin 10	Rattus norvegicus	70-75
24482305-5	2014	In EAN sciatic nerves, curcumin treatment suppressed the inflammatory cell accumulation and the expression of interferon (IFN)-gamma, tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-17.	Curcumin	23-31	interleukin 17A	Rattus norvegicus	191-196
24482305-7	2014	In addition, curcumin altered helper T cell differentiation by decreasing IFN-gamma(+) CD4(+) Th1 cells in EAN lymph node and spleen.	Curcumin	13-21	interferon gamma	Rattus norvegicus	74-83
24735534-6	2014	Finally, we found that C6 ceramide enhanced curcumin-induced cytotoxicity probably through facilitating mPTP opening, while CsA and SfA as well as CyPD and ANT-1 siRNAs alleviated C6 ceramide"s effect on curcumin in WM-115 cells.	Curcumin	204-212	solute carrier family 25 member 4	Homo sapiens	156-161
26414021-0	2016	Curcumin raises lipid content by Wnt pathway in hepatic stellate cell.	Curcumin	0-8	Wnt family member 2	Rattus norvegicus	33-36
26707143-8	2016	In addition, the sustained activation of the ROS-ASK1-c-Jun N-terminal kinase pathway may be an important mediator of the synergistic effect of curcumin and ABT-737.	Curcumin	144-152	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	49-53
26707143-0	2016	Curcumin enhances the antitumor effect of ABT-737 via activation of the ROS-ASK1-JNK pathway in hepatocellular carcinoma cells.	Curcumin	0-8	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	76-80
26573768-7	2016	Furthermore, curcumin suppressed the activation of AKT, mTOR and P70S6K proteins.	Curcumin	13-21	ribosomal protein S6 kinase B1	Homo sapiens	65-71
26893768-6	2016	Furthermore, curcumin was able to effectively inhibit the HGF-induced increase in the levels of vimentin by downregulating the expression of phosphorylated c-Met, extracellular signal-regulated kinase and Snail.	Curcumin	13-21	vimentin	Homo sapiens	96-104
27595397-10	2016	RESULTS: Curcumin and KN93 significantly inhibited the activation of CaMKII/NF-kappaB signaling induced by diabetes or elevated glucose, and subsequently decreased the expression of VEGF, iNOS and ICAM-1.	Curcumin	9-17	vascular endothelial growth factor A	Rattus norvegicus	182-186
24892628-1	2016	PURPOSE: The present study was to formulate curcumin solid lipid nanoparticles (Cur-SLNs) with P-gp modulator excipients, TPGS and Brij78, to enhance the solubility and bioavailability of curcumin.	Curcumin	44-52	phosphoglycolate phosphatase	Homo sapiens	95-99
24892628-1	2016	PURPOSE: The present study was to formulate curcumin solid lipid nanoparticles (Cur-SLNs) with P-gp modulator excipients, TPGS and Brij78, to enhance the solubility and bioavailability of curcumin.	Curcumin	188-196	phosphoglycolate phosphatase	Homo sapiens	95-99
26442630-8	2016	In addition, the ATM-specific inhibitor KU-55933 reversed curcumin-induced phosphorylation of H2A.X.	Curcumin	58-66	ATM serine/threonine kinase	Homo sapiens	17-20
26442630-9	2016	These results collectively show that curcumin treatment induced the DNA damage response via triggering an ATM-activated Chk2-Cdc25C-Cdc2 signaling pathway.	Curcumin	37-45	ATM serine/threonine kinase	Homo sapiens	106-109
26442630-9	2016	These results collectively show that curcumin treatment induced the DNA damage response via triggering an ATM-activated Chk2-Cdc25C-Cdc2 signaling pathway.	Curcumin	37-45	cell division cycle 25C	Homo sapiens	125-131
26442630-9	2016	These results collectively show that curcumin treatment induced the DNA damage response via triggering an ATM-activated Chk2-Cdc25C-Cdc2 signaling pathway.	Curcumin	37-45	cyclin dependent kinase 1	Homo sapiens	125-129
26467482-3	2016	The present study explored whether curcumin is able to prevent the cisplatin-induced fibrosis and decreased expression of the TJ and adherens junction (AJ) proteins occludin, claudin-2 and E-cadherin in cisplatin-induced nephrotoxicity.	Curcumin	35-43	cadherin 1	Rattus norvegicus	189-199
26989696-7	2016	Furthermore, curcumin treatment markedly inhibited the reduced Bcl-2/Bax ratio elicited by high glucose exposure.	Curcumin	13-21	BCL2 associated X, apoptosis regulator	Rattus norvegicus	69-72
26437580-7	2016	Key transcription factors and other regulatory molecules (ERK, FN1, TNFSF12 and PI3K complex) activated in inflammation were down-regulated by dietary intervention with curcumin.	Curcumin	169-177	fibronectin 1	Mus musculus	63-66
26456563-6	2016	Increased expression of UCP1 and other brown adipocyte-specific markers was possibly mediated by curcumin-induced activation of AMP-activated protein kinase (AMPK) based on the fact that inhibition of AMPK by dorsomorphin abolished expression of PRDM16, UCP1 and peroxisome proliferator-activated receptor gamma co-activator 1-alpha while the activator 5-Aminoimidazole-4-carboxamide ribonucleotide elevated expression of these brown marker proteins.	Curcumin	97-105	uncoupling protein 1	Homo sapiens	24-28
26456563-6	2016	Increased expression of UCP1 and other brown adipocyte-specific markers was possibly mediated by curcumin-induced activation of AMP-activated protein kinase (AMPK) based on the fact that inhibition of AMPK by dorsomorphin abolished expression of PRDM16, UCP1 and peroxisome proliferator-activated receptor gamma co-activator 1-alpha while the activator 5-Aminoimidazole-4-carboxamide ribonucleotide elevated expression of these brown marker proteins.	Curcumin	97-105	uncoupling protein 1	Homo sapiens	254-258
26767865-8	2016	Pre-treatment with a p38 inhibitor, a JNK inhibitor, or curcumin significantly inhibited Ang III-induced MCP-1 production.	Curcumin	56-64	C-C motif chemokine ligand 2	Homo sapiens	105-110
29630139-3	2016	The dominant theory of theAD development is amyloid cascadehypothesis, but at the same time, importantin the etiology of this disease isthe overphosphorylation of tau protein.Despite many years of research, so far,there are no drugs that allow for effectivetherapy, hence the ongoing intensiveexploration of natural substancesthat can prevent the AD development.Bioactive components of plant originhave recently received considerableattention, because they are relativelysafe and cheap due to the wide availability,and quite promising in thisgroup are curcumin and resveratrol.	Curcumin	552-560	microtubule associated protein tau	Homo sapiens	163-166
26612707-5	2016	Moreover, Curcumin/CMC-peptide treatment during hypertrophy significantly improved cardiac function by downregulating expression of hypertrophy marker genes (ANF, beta-MHC), apoptotic mediators (Bax, Cytochrome-c) and activity of apoptotic markers (Caspase 3 and PARP); whereas free Curcumin in much higher dose showed minimal improvement during compromised cardiac function.	Curcumin	10-18	BCL2 associated X, apoptosis regulator	Rattus norvegicus	195-198
26612707-6	2016	Targeted Curcumin treatment significantly lowered p53 expression and activation in diseased myocardium via inhibited interaction of p53 with p300-HAT.	Curcumin	9-17	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	50-53
26612707-6	2016	Targeted Curcumin treatment significantly lowered p53 expression and activation in diseased myocardium via inhibited interaction of p53 with p300-HAT.	Curcumin	9-17	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	132-135
26488450-0	2015	A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer"s disease.	Curcumin	2-10	microtubule associated protein tau	Homo sapiens	75-78
26488450-2	2015	In order to develop a curcumin-based NIR fluorescent probe for tau fibrils, structural modification of the curcumin scaffold was attempted by combining the following rationales: the curcumin derivative should preserve its binding affinity to tau fibrils, and, upon binding to tau fibrils, the probe should show favorable fluorescence properties.	Curcumin	22-30	microtubule associated protein tau	Homo sapiens	63-66
26488450-2	2015	In order to develop a curcumin-based NIR fluorescent probe for tau fibrils, structural modification of the curcumin scaffold was attempted by combining the following rationales: the curcumin derivative should preserve its binding affinity to tau fibrils, and, upon binding to tau fibrils, the probe should show favorable fluorescence properties.	Curcumin	22-30	microtubule associated protein tau	Homo sapiens	242-245
26488450-2	2015	In order to develop a curcumin-based NIR fluorescent probe for tau fibrils, structural modification of the curcumin scaffold was attempted by combining the following rationales: the curcumin derivative should preserve its binding affinity to tau fibrils, and, upon binding to tau fibrils, the probe should show favorable fluorescence properties.	Curcumin	22-30	microtubule associated protein tau	Homo sapiens	242-245
26488450-2	2015	In order to develop a curcumin-based NIR fluorescent probe for tau fibrils, structural modification of the curcumin scaffold was attempted by combining the following rationales: the curcumin derivative should preserve its binding affinity to tau fibrils, and, upon binding to tau fibrils, the probe should show favorable fluorescence properties.	Curcumin	107-115	microtubule associated protein tau	Homo sapiens	242-245
26488450-2	2015	In order to develop a curcumin-based NIR fluorescent probe for tau fibrils, structural modification of the curcumin scaffold was attempted by combining the following rationales: the curcumin derivative should preserve its binding affinity to tau fibrils, and, upon binding to tau fibrils, the probe should show favorable fluorescence properties.	Curcumin	107-115	microtubule associated protein tau	Homo sapiens	242-245
26488450-2	2015	In order to develop a curcumin-based NIR fluorescent probe for tau fibrils, structural modification of the curcumin scaffold was attempted by combining the following rationales: the curcumin derivative should preserve its binding affinity to tau fibrils, and, upon binding to tau fibrils, the probe should show favorable fluorescence properties.	Curcumin	107-115	microtubule associated protein tau	Homo sapiens	242-245
26488450-2	2015	In order to develop a curcumin-based NIR fluorescent probe for tau fibrils, structural modification of the curcumin scaffold was attempted by combining the following rationales: the curcumin derivative should preserve its binding affinity to tau fibrils, and, upon binding to tau fibrils, the probe should show favorable fluorescence properties.	Curcumin	107-115	microtubule associated protein tau	Homo sapiens	242-245
26488450-4	2015	Among the series, the curcumin derivative with a (4-dimethylamino-2,6-dimethoxy)phenyl moiety showed a significant change in its fluorescence properties (22.9-fold increase in quantum yield; Kd, 0.77 muM; lambdaem, 620 nm; Phi, 0.32) after binding to tau fibrils.	Curcumin	22-30	microtubule associated protein tau	Homo sapiens	251-254
26585812-0	2015	Curcumin Suppresses Phthalate-Induced Metastasis and the Proportion of Cancer Stem Cell (CSC)-like Cells via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma.	Curcumin	0-8	sphingosine kinase 1	Homo sapiens	135-138
26585812-6	2015	We also reveal that curcumin suppressed phthalate-induced migration, invasion, and CSC-like cell maintenance through inhibition of the aryl hydrocarbon receptor/ERK/SK1/S1P3 signaling pathway.	Curcumin	20-28	sphingosine kinase 1	Homo sapiens	165-168
26630272-4	2015	Combinations of alpha-tomatine and curcumin synergistically inhibited the growth and induced apoptosis in prostate cancer PC-3 cells.	Curcumin	35-43	proprotein convertase subtilisin/kexin type 1	Homo sapiens	122-126
26630272-6	2015	Moreover, strong decreases in the levels of phospho-Akt and phosphor-ERK1/2 were found in PC-3 cells treated with alpha-tomatine and curcumin in combination.	Curcumin	133-141	proprotein convertase subtilisin/kexin type 1	Homo sapiens	90-94
26630272-8	2015	Combination of alpha-tomatine and curcumin more potently inhibited the growth of PC-3 tumors than either agent alone.	Curcumin	34-42	proprotein convertase subtilisin/kexin type 1	Homo sapiens	81-85
26456836-11	2015	Curcumin also inhibited superoxide anion-induced leukocyte recruitment in the peritoneal cavity and in the paw skin inhibited myeloperoxidase activity, oxidative stress, IL-1beta and TNF-alpha production and NF-kappaB activation as well as enhanced IL-10 production, and HO-1 and Nrf2 mRNA expression.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	271-275
26499200-0	2015	Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1alpha signaling.	Curcumin	0-8	monoamine oxidase A	Homo sapiens	87-91
26499200-6	2015	However, curcumin abrogated CAF-induced invasion and EMT, and inhibited ROS production and CXCR4 and IL-6 receptor expression in prostate cancer cells through inhibiting MAOA/mTOR/HIF-1alpha signaling, thereby supporting the therapeutic effect of curcumin in prostate cancer.	Curcumin	9-17	monoamine oxidase A	Homo sapiens	170-174
26755923-0	2015	Curcumin attenuates the middle cerebral artery occlusion-induced reduction in gamma-enolase expression in an animal model.	Curcumin	0-8	enolase 2	Rattus norvegicus	78-91
26755923-3	2015	We investigated whether curcumin regulates gamma-enolase expression in focal cerebral ischemic injury in rats.	Curcumin	24-32	enolase 2	Rattus norvegicus	43-56
26755923-8	2015	Reverse-transcription PCR and Western blot analyses also showed that curcumin treatment prevented the MCAO injury-induced reduction in gamma-enolase expression.	Curcumin	69-77	enolase 2	Rattus norvegicus	135-148
26755923-9	2015	The results of this study suggest that curcumin exerts its neuroprotective function in focal cerebral ischemia by regulating the expression of gamma-enolase.	Curcumin	39-47	enolase 2	Rattus norvegicus	143-156
26469832-3	2015	This paper focuses on curcumin as an adjuvant molecule to cisplatin by analysing its potential implications on the molecular targets, signal transducer and activator of transcription 3 (STAT3) and NF-E2 p45-related factor 2 (Nrf-2), in tumour progression and cisplatin resistance in vitro and the adverse effect ototoxicity in vivo.	Curcumin	22-30	signal transducer and activator of transcription 3	Rattus norvegicus	134-184
26469832-3	2015	This paper focuses on curcumin as an adjuvant molecule to cisplatin by analysing its potential implications on the molecular targets, signal transducer and activator of transcription 3 (STAT3) and NF-E2 p45-related factor 2 (Nrf-2), in tumour progression and cisplatin resistance in vitro and the adverse effect ototoxicity in vivo.	Curcumin	22-30	signal transducer and activator of transcription 3	Rattus norvegicus	186-191
26473373-0	2015	Migration-prone glioma cells show curcumin resistance associated with enhanced expression of miR-21 and invasion/anti-apoptosis-related proteins.	Curcumin	34-42	microRNA 21	Homo sapiens	93-99
26473373-6	2015	Furthermore, treatment with curcumin decreased the miR-21 level and anti-apoptotic protein expression, and increased the expression of pro-apoptosis proteins and microtubule-associated protein light chain 3-II (LC3-II) in U251 cells.	Curcumin	28-36	microRNA 21	Homo sapiens	51-57
26250869-6	2015	The inhibition of NLRP3 inflammasome by curcumin was in part mediated via the suppression of extracellular regulated protein kinases phosphorylation.	Curcumin	40-48	NLR family, pyrin domain containing 3	Mus musculus	18-23
26250869-8	2015	CONCLUSION: Curcumin potently inhibits the activation of NLRP3 inflammasome which may contribute to its anti-inflammatory activity.	Curcumin	12-20	NLR family, pyrin domain containing 3	Mus musculus	57-62
26250869-9	2015	Our finding offers a mechanistic basis for the therapeutic potential of curcumin in septic shock and other NLRP3 inflammasome-driven diseases.	Curcumin	72-80	NLR family, pyrin domain containing 3	Mus musculus	107-112
26490686-9	2015	Results of immunohistochemistry and western-blot showed decreased expressions of VEGF, TGF-ss1, and IGF1 were also decreased in the curcumin group.	Curcumin	132-140	vascular endothelial growth factor A	Rattus norvegicus	81-85
26490686-9	2015	Results of immunohistochemistry and western-blot showed decreased expressions of VEGF, TGF-ss1, and IGF1 were also decreased in the curcumin group.	Curcumin	132-140	insulin-like growth factor 1	Rattus norvegicus	100-104
26362189-7	2015	In addition, curcumin promotes beta3AR gene expression in inguinal WAT and elevates the levels of plasma norepinephrine, a hormone that can induce WAT browning.	Curcumin	13-21	adrenergic receptor, beta 3	Mus musculus	31-38
26362189-8	2015	Taken together, our data suggest that curcumin can potentially prevent obesity by inducing browning of inguinal WAT via the norepinephrine-beta3AR pathway.	Curcumin	38-46	adrenergic receptor, beta 3	Mus musculus	139-146
26300394-6	2015	Treatment of SCI rats with curcumin increased osteocalcin mRNA expression and reduced mRNA levels of tartrate-resistant acid phosphatase and mRNA ratio of receptor activator of NF-kappaB ligand/osteoprotegerin in distal femurs.	Curcumin	27-35	TNF receptor superfamily member 11B	Rattus norvegicus	194-209
26300394-8	2015	Treatment of SCI rats with curcumin had no significant effect on serum 25(OH)D, but enhanced mRNA and protein expression of vitamin D receptor (VDR) in distal femurs.	Curcumin	27-35	vitamin D receptor	Rattus norvegicus	124-142
26300394-8	2015	Treatment of SCI rats with curcumin had no significant effect on serum 25(OH)D, but enhanced mRNA and protein expression of vitamin D receptor (VDR) in distal femurs.	Curcumin	27-35	vitamin D receptor	Rattus norvegicus	144-147
26300394-9	2015	Treatment of SCI rats with curcumin enhanced mRNA levels of Wnt3a, Lrp5, and ctnnb1 and upregulated protein expression of beta-catenin in distal femurs.	Curcumin	27-35	catenin beta 1	Rattus norvegicus	77-83
26089209-6	2015	We also illuminate on how resveratrol, epigallocatechin gallate, curcumin, jaceosidin, cucurbitacin, apigenin, genistein, and others trigger activation of ATM in different cancer cells as well as agents for ATM inactivation.	Curcumin	65-73	ATM serine/threonine kinase	Homo sapiens	155-158
26089209-6	2015	We also illuminate on how resveratrol, epigallocatechin gallate, curcumin, jaceosidin, cucurbitacin, apigenin, genistein, and others trigger activation of ATM in different cancer cells as well as agents for ATM inactivation.	Curcumin	65-73	ATM serine/threonine kinase	Homo sapiens	207-210
26166196-8	2015	The findings revealed that curcumin significantly decreased cell proliferation, which was associated with increased expression of the p21/CIP1 and p27/KIP1 cyclin-dependent kinase inhibitors, and inhibited expression of cyclin D1.	Curcumin	27-35	H3 histone pseudogene 16	Homo sapiens	134-137
26166196-8	2015	The findings revealed that curcumin significantly decreased cell proliferation, which was associated with increased expression of the p21/CIP1 and p27/KIP1 cyclin-dependent kinase inhibitors, and inhibited expression of cyclin D1.	Curcumin	27-35	interferon alpha inducible protein 27	Homo sapiens	147-179
26166196-9	2015	In addition, curcumin induced apoptosis by decreasing the Bcl-2/Bax protein ratio and increasing caspase-9/3 activation in the pancreatic cancer cells.	Curcumin	13-21	caspase 9	Homo sapiens	97-106
26190183-12	2015	In addition, curcumin also attenuated increased expression of GFAP and Iba-1 in animals with PTZ induced chronic epilepsy.	Curcumin	13-21	allograft inflammatory factor 1	Rattus norvegicus	71-76
26305550-5	2015	We found that curcumin can inhibit IDO expression and TNF-alpha-induced EMT.	Curcumin	14-22	indoleamine 2,3-dioxygenase 1	Mus musculus	35-38
26202962-6	2015	Sub-lethal curcumin exposure results in reduced bimodality of all hTERT splice variants and significant upregulation of alpha splicing, suggesting a possible role in cellular stress response.	Curcumin	11-19	telomerase reverse transcriptase	Homo sapiens	66-71
26396931-3	2015	Curcumin, a neuroprotective food additive, has been shown to rescue Tg P23H rat rod PRs and promote normal trafficking of rhodopsin.	Curcumin	0-8	rhodopsin	Rattus norvegicus	122-131
26617882-7	2015	The expression levels of CytC, Casp3 and Casp8 of the NASH livers were significantly higher than normal and NASH treated with curcumin rats livers.	Curcumin	126-134	SAM domain, SH3 domain and nuclear localization signals, 1	Rattus norvegicus	54-58
26617882-7	2015	The expression levels of CytC, Casp3 and Casp8 of the NASH livers were significantly higher than normal and NASH treated with curcumin rats livers.	Curcumin	126-134	SAM domain, SH3 domain and nuclear localization signals, 1	Rattus norvegicus	108-112
26617882-8	2015	CONCLUSION: Our data demonstrated that curcumin prevents the NASH by mitochondria protection and apoptosis reduction and provided a possible novel treatment for NASH.	Curcumin	39-47	SAM domain, SH3 domain and nuclear localization signals, 1	Rattus norvegicus	61-65
26617882-8	2015	CONCLUSION: Our data demonstrated that curcumin prevents the NASH by mitochondria protection and apoptosis reduction and provided a possible novel treatment for NASH.	Curcumin	39-47	SAM domain, SH3 domain and nuclear localization signals, 1	Rattus norvegicus	161-165
25982942-7	2015	In addition, curcumin significantly reduced the level of MDA and increased the activities of SOD and AChE.	Curcumin	13-21	acetylcholinesterase	Rattus norvegicus	101-105
26294283-0	2015	Curcumin Increases HSP70 Expression in Primary Rat Cortical Neuronal Apoptosis Induced by gp120 V3 Loop Peptide.	Curcumin	0-8	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	19-24
26294283-7	2015	We also found that curcumin could increase HSP70 expression.	Curcumin	19-27	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	43-48
26294283-8	2015	In addition, the expression level of both HSP70 mRNA and HSP70 protein were dependent on the curcumin dose in the rat cortical neurons.	Curcumin	93-101	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	42-47
26294283-8	2015	In addition, the expression level of both HSP70 mRNA and HSP70 protein were dependent on the curcumin dose in the rat cortical neurons.	Curcumin	93-101	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	57-62
26294283-9	2015	Curcumin could improve HSP70 expression in gp120 V3 loop peptide-induced primary rat cortical neuronal apoptosis.	Curcumin	0-8	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	23-28
26294283-10	2015	In general, our results indicated that curcumin played an important role in the gp120 V3 loop peptide induced neuronal apoptosis by regulating HSP70.	Curcumin	39-47	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	143-148
26622667-7	2015	MEK1 overexpression partially blocked the anti-metastatic effects of curcumin.	Curcumin	69-77	mitogen-activated protein kinase kinase 1	Homo sapiens	0-4
26357462-6	2015	The presence of an ester linkage between the phenolic rings in (-)-epigallocatechin-3-gallate (EGCG) and the alkyl chain in curcumin allows them to orient in the active site of the HMGR and bind to the catalytic residues.	Curcumin	124-132	high mobility group AT-hook 1	Homo sapiens	181-185
26357462-7	2015	EGCG and curcumin showed binding to the active site residues with a low GRID score, which may be a potential inhibitor of HMGR.	Curcumin	9-17	high mobility group AT-hook 1	Homo sapiens	122-126
26244872-5	2015	Curcumin, a nutrient with anti-Jak3 activity and histone deacetylase inhibitors (HDACi) also trigger increased expression of pri-miR-22 and miR-22.	Curcumin	0-8	Janus kinase 3	Homo sapiens	31-35
26116776-4	2015	At the molecular level, curcumin and ABT-737 synergistically induced mitochondrial permeability transition pore (mPTP) opening in melanoma cells, the latter was evidenced by mitochondrial membrane potential (MPP) reduction and mitochondrial complexation between cyclophilin-D (CyPD) and adenine nucleotide translocator 1 (ANT-1).	Curcumin	24-32	solute carrier family 25 member 4	Homo sapiens	287-320
26116776-4	2015	At the molecular level, curcumin and ABT-737 synergistically induced mitochondrial permeability transition pore (mPTP) opening in melanoma cells, the latter was evidenced by mitochondrial membrane potential (MPP) reduction and mitochondrial complexation between cyclophilin-D (CyPD) and adenine nucleotide translocator 1 (ANT-1).	Curcumin	24-32	solute carrier family 25 member 4	Homo sapiens	322-327
26199414-3	2015	In this article, we demonstrated that CRANAD-3, a curcumin analog, is capable of detecting both soluble and insoluble Abeta species.	Curcumin	50-58	amyloid beta (A4) precursor protein	Mus musculus	118-123
26199414-7	2015	To validate the imaging capacity of CRANAD-3 further, we used it to monitor the therapeutic effect of CRANAD-17, a curcumin analog for inhibition of Abeta cross-linking.	Curcumin	115-123	amyloid beta (A4) precursor protein	Mus musculus	149-154
25441423-0	2015	Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells.	Curcumin	22-30	chromobox 8	Homo sapiens	88-91
25441423-2	2015	The aim of this study was to verify the combined beneficial anticancer effects of curcumin and EGCG on PC3 prostate cancer cells, which are resistant to chemotherapy drugs and apoptosis inducers.	Curcumin	82-90	chromobox 8	Homo sapiens	103-106
25441423-4	2015	Co-treatment of curcumin improved antiproliferative effect of EGCG on PC3 cells.	Curcumin	16-24	chromobox 8	Homo sapiens	70-73
25441423-5	2015	The protein expressions of p21 were significantly increased by the co-treatment of EGCG and curcumin, whereas it was not changed by the treatment with each individual compound.	Curcumin	92-100	H3 histone pseudogene 16	Homo sapiens	27-30
25441423-6	2015	Moreover, treatments of EGCG and curcumin arrested both S and G2/M phases of PC3 cells.	Curcumin	33-41	chromobox 8	Homo sapiens	77-80
25441423-7	2015	These results suggest that the enhanced inhibitory effect of EGCG on PC3 cell proliferation by curcumin was mediated by the synergic up-regulation of p21-induced growth arrest and followed cell growth arrest.	Curcumin	95-103	chromobox 8	Homo sapiens	69-72
25441423-7	2015	These results suggest that the enhanced inhibitory effect of EGCG on PC3 cell proliferation by curcumin was mediated by the synergic up-regulation of p21-induced growth arrest and followed cell growth arrest.	Curcumin	95-103	H3 histone pseudogene 16	Homo sapiens	150-153
26037703-2	2015	3,4-Difluorobenzylidene curcumin (CDF) is a nontoxic analog of curcumin (CMN) developed in our laboratory, which exhibits extended circulation half-life, while maintaining high anticancer activity and improved pancreas specific accumulation in vivo, compared with CMN.	Curcumin	24-32	LIF interleukin 6 family cytokine	Homo sapiens	34-37
26143367-0	2015	Development and evaluation of gastroretentive raft forming systems incorporating curcumin-Eudragit  EPO solid dispersions for gastric ulcer treatment.	Curcumin	81-89	erythropoietin	Rattus norvegicus	100-103
26143367-1	2015	Novel raft forming systems incorporating curcumin-Eudragit  EPO solid dispersions were developed to prolong the gastric residence time and provide for a controlled release therapy of curcumin to treat gastric ulcers.	Curcumin	41-49	erythropoietin	Rattus norvegicus	60-63
26143367-1	2015	Novel raft forming systems incorporating curcumin-Eudragit  EPO solid dispersions were developed to prolong the gastric residence time and provide for a controlled release therapy of curcumin to treat gastric ulcers.	Curcumin	183-191	erythropoietin	Rattus norvegicus	60-63
26147007-2	2015	Curcumin, the active ingredient of the curry spice turmeric, has anti-inflammatory properties, and thus may have the capacity to regulate Th2 cells and mucosal mast cell function during allergic responses.	Curcumin	0-8	heart and neural crest derivatives expressed 2	Mus musculus	138-141
26147007-8	2015	Furthermore, allergic diarrhea, mast cell activation and expansion, and Th2 responses were also suppressed in mice exposed to curcumin during the OVA-challenge phase alone, despite the presence of elevated levels of OVA-IgE, suggesting that curcumin may have a direct suppressive effect on intestinal mast cell activation and reverse food allergy symptoms in allergen-sensitized individuals.	Curcumin	126-134	heart and neural crest derivatives expressed 2	Mus musculus	72-75
25874494-6	2015	Downregulation of lymphatic vessel endothelial receptor 1 (LYVE-1), Prox-1, podoplanin, and VEGFR-3 mRNA expression by curcumin was also detected (all P &lt; 0.05).	Curcumin	119-127	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	18-57
25874494-6	2015	Downregulation of lymphatic vessel endothelial receptor 1 (LYVE-1), Prox-1, podoplanin, and VEGFR-3 mRNA expression by curcumin was also detected (all P &lt; 0.05).	Curcumin	119-127	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	59-65
26048285-5	2015	Curcumin prophylaxis significantly attenuated the upregulation of NF-kappaB (p &lt; 0.001), thereby leading to concomitant downregulation of pro-inflammatory cytokine levels ( IL-1, IL-2, IL-18 and TNF-alpha), cell adhesion molecules ( P-selectin and E-selectin) and increased anti-inflammatory cytokine ( IL-10).	Curcumin	0-8	interleukin 2	Rattus norvegicus	182-186
26048285-5	2015	Curcumin prophylaxis significantly attenuated the upregulation of NF-kappaB (p &lt; 0.001), thereby leading to concomitant downregulation of pro-inflammatory cytokine levels ( IL-1, IL-2, IL-18 and TNF-alpha), cell adhesion molecules ( P-selectin and E-selectin) and increased anti-inflammatory cytokine ( IL-10).	Curcumin	0-8	interleukin 18	Rattus norvegicus	188-193
26048285-5	2015	Curcumin prophylaxis significantly attenuated the upregulation of NF-kappaB (p &lt; 0.001), thereby leading to concomitant downregulation of pro-inflammatory cytokine levels ( IL-1, IL-2, IL-18 and TNF-alpha), cell adhesion molecules ( P-selectin and E-selectin) and increased anti-inflammatory cytokine ( IL-10).	Curcumin	0-8	interleukin 10	Rattus norvegicus	306-311
26048285-6	2015	Curcumin stabilized the brain HIF-1alpha levels followed by maintaining VEGF levels along with upregulated Na(+)/K(+)-ATPase and ENaC levels (p &lt; 0.001) under hypoxia.	Curcumin	0-8	vascular endothelial growth factor A	Rattus norvegicus	72-76
26048285-7	2015	Curcumin restored the brain ZO-1, JAMC, claudin 4 and claudin 5 levels (p &lt; 0.001) under hypoxia.	Curcumin	0-8	tight junction protein 1	Rattus norvegicus	28-32
26035833-0	2015	Curcumin Treatment Improves Motor Behavior in alpha-Synuclein Transgenic Mice.	Curcumin	0-8	synuclein, alpha	Mus musculus	46-61
26035833-1	2015	The curry spice curcumin plays a protective role in mouse models of neurodegenerative diseases, and can also directly modulate aggregation of alpha-synuclein protein in vitro, yet no studies have described the interaction of curcumin and alpha-synuclein in genetic synucleinopathy mouse models.	Curcumin	16-24	synuclein, alpha	Mus musculus	142-157
26035833-1	2015	The curry spice curcumin plays a protective role in mouse models of neurodegenerative diseases, and can also directly modulate aggregation of alpha-synuclein protein in vitro, yet no studies have described the interaction of curcumin and alpha-synuclein in genetic synucleinopathy mouse models.	Curcumin	16-24	synuclein, alpha	Mus musculus	238-253
25632966-7	2015	Further, treatment of curcumin and resveratrol to BP-treated mice significantly elevated the activities of SOD, GR, and GST.	Curcumin	22-30	hematopoietic prostaglandin D synthase	Mus musculus	120-123
26108778-9	2015	CONCLUSION: Radiation sensitization effect of curcumin on colorectal cancer cells HT-29 may be associated with the regulation of genes of CCNH, LIG4, XRCC5, PNKP.	Curcumin	46-54	DNA ligase 4	Homo sapiens	144-148
25725129-0	2015	MicroRNA-33b, upregulated by EF24, a curcumin analog, suppresses the epithelial-to-mesenchymal transition (EMT) and migratory potential of melanoma cells by targeting HMGA2.	Curcumin	37-45	high mobility group AT-hook 2	Homo sapiens	167-172
25891083-0	2015	Curcumin inhibits appoptosin-induced apoptosis via upregulating heme oxygenase-1 expression in SH-SY5Y cells.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	64-80
25964545-2	2015	Recently, we reported on the synthesis of curcumin analogues and their evaluation as selective COX1 inhibitors.	Curcumin	42-50	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	95-99
25799055-5	2015	We observed Rcan1 isoform 1 (Rcan1-1) protein reduction in mice pup hippocampus after a 4-week curcumin and fish oil supplementation, with only fish oil reduction being statistically significant.	Curcumin	95-103	regulator of calcineurin 1	Homo sapiens	12-17
25856395-5	2015	Curcumin pre-treatment also abrogated the gp120-mediated upregulation of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin (IL)-6, which mediate barrier disruption, as well as the chemokines IL-8, RANTES and interferon gamma-induced protein-10 (IP-10), which are capable of recruiting HIV target cells to the FGT.	Curcumin	0-8	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	42-47
25849376-10	2015	Notably, curcumin administration in MCD-fed mice dramatically reduced CYP2E1 as well as Prx1 expression, while upregulating Prx6 expression.	Curcumin	9-17	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	70-76
25849376-10	2015	Notably, curcumin administration in MCD-fed mice dramatically reduced CYP2E1 as well as Prx1 expression, while upregulating Prx6 expression.	Curcumin	9-17	peroxiredoxin 1	Mus musculus	88-92
25786122-7	2015	Expression of downstream effectors of TGF-beta signaling pathway, cyclinD1, p21 and Pin1, was inhibited along with the down regulation of key mesenchymal markers (Snail and Slug) upon curcumin and emodin treatment.	Curcumin	184-192	H3 histone pseudogene 16	Homo sapiens	76-79
25786122-7	2015	Expression of downstream effectors of TGF-beta signaling pathway, cyclinD1, p21 and Pin1, was inhibited along with the down regulation of key mesenchymal markers (Snail and Slug) upon curcumin and emodin treatment.	Curcumin	184-192	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	84-88
25786122-9	2015	Moreover, we found that TGF-beta activates Wnt/beta-catenin signaling pathway in HeLa cells, and curcumin and emodin down regulate the pathway by inhibiting beta-catenin.	Curcumin	97-105	catenin beta 1	Homo sapiens	157-169
26248429-0	2015	[Curcumin induces apoptosis by PTEN/PI3K/AKT pathway in EC109 cells].	Curcumin	1-9	phosphatase and tensin homolog	Homo sapiens	31-35
25602852-3	2015	Further research on its underlying mechanism showed that curcumin suppressed transition of the cells from G1 to S phase and enhanced the expression of Sox4, Sox2, and Oct4, which were essential to retain the stemness properties of glioma-initiating cells.	Curcumin	57-65	POU class 5 homeobox 1	Homo sapiens	167-171
25649709-0	2015	Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner.	Curcumin	0-8	ATM serine/threonine kinase	Homo sapiens	96-99
25649709-11	2015	Thus, we have shown that curcumin can induce senescence of cells building the vasculature, which is DNA damage and ATM independent and is not induced by increased reactive oxygen species (ROS) level.	Curcumin	25-33	ATM serine/threonine kinase	Homo sapiens	115-118
25647661-6	2015	CCM supplementation dose-dependently increased grip strength and endurance performance and significantly decreased lactate, ammonia, BUN, AST, ALT, and CK levels after physical challenge.	Curcumin	0-3	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	138-141
25647661-6	2015	CCM supplementation dose-dependently increased grip strength and endurance performance and significantly decreased lactate, ammonia, BUN, AST, ALT, and CK levels after physical challenge.	Curcumin	0-3	glutamic pyruvic transaminase, soluble	Mus musculus	143-146
26136617-1	2015	Curcumin feeding of Drosophila larvae or young adults inhibits TOR and other known longevity genes and induces an extended health span in a normal-lived Ra strain adult.	Curcumin	0-8	Target of rapamycin	Drosophila melanogaster	63-66
25640336-7	2015	Curcumin significantly lowered the serum levels of AFP, IL-2 and IL-6, ALT, ALT, and malondialdehyde (MDA) as well gene expression of IL-2 and IL-6.	Curcumin	0-8	interleukin 2	Rattus norvegicus	56-60
25640336-7	2015	Curcumin significantly lowered the serum levels of AFP, IL-2 and IL-6, ALT, ALT, and malondialdehyde (MDA) as well gene expression of IL-2 and IL-6.	Curcumin	0-8	interleukin 2	Rattus norvegicus	134-138
26235577-6	2015	Results showed that pretreatment with curcumin significantly attenuated the H2O2-induced HUVECs" premature senescence, which was evidenced by a decreased percentage of senescence-associated beta-galactosidase positive cells, improved cell division and decreased expression of senescence-associated protein p21 (all p&lt;0.05).	Curcumin	38-46	H3 histone pseudogene 16	Homo sapiens	306-309
25333322-0	2015	Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells.	Curcumin	0-8	fibrillin 1	Homo sapiens	96-107
25333322-2	2015	In this presented study, we found that curcumin can enhance the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells via increasing ELN and FBN1 promoters" activities.	Curcumin	39-47	fibrillin 1	Homo sapiens	138-149
25333322-2	2015	In this presented study, we found that curcumin can enhance the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells via increasing ELN and FBN1 promoters" activities.	Curcumin	39-47	fibrillin 1	Homo sapiens	207-211
25333322-3	2015	With 2 muM curcumin treatment, the enhanced tropoelastin and fibrillin-1 protein amounts in Detroit 551 cells were approximately 134 and 130% of control, respectively.	Curcumin	11-19	fibrillin 1	Homo sapiens	61-72
25492214-4	2015	According to the flow cytometric analysis, curcumin treatment resulted in G2/M arrest in AGS cells, accompanied with an increased expression of cyclin B1 and a decreased expression of cyclin D1.	Curcumin	43-51	cyclin B1	Homo sapiens	144-153
26626244-0	2015	Curcumin Reduces Tumour Necrosis Factor-Enhanced Annexin V-Positive Microparticle Release in Human Vascular Endothelial Cells.	Curcumin	0-8	annexin A5	Homo sapiens	49-58
25435978-1	2015	The aim of the present study was to explore the effects of curcumin in combination with bevacizumab on the vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)/K-ras pathway in hepatocellular carcinoma.	Curcumin	59-67	vascular endothelial growth factor A	Rattus norvegicus	107-141
25435978-1	2015	The aim of the present study was to explore the effects of curcumin in combination with bevacizumab on the vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)/K-ras pathway in hepatocellular carcinoma.	Curcumin	59-67	vascular endothelial growth factor A	Rattus norvegicus	143-147
25435978-1	2015	The aim of the present study was to explore the effects of curcumin in combination with bevacizumab on the vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)/K-ras pathway in hepatocellular carcinoma.	Curcumin	59-67	vascular endothelial growth factor A	Rattus norvegicus	149-153
25435978-4	2015	Compared with the control group, the mRNA levels of VEGF and VEGFR were revealed to be significantly increased in the model, curcumin and VEGF blocker groups.	Curcumin	125-133	vascular endothelial growth factor A	Rattus norvegicus	52-56
25435978-4	2015	Compared with the control group, the mRNA levels of VEGF and VEGFR were revealed to be significantly increased in the model, curcumin and VEGF blocker groups.	Curcumin	125-133	vascular endothelial growth factor A	Rattus norvegicus	61-65
25435978-5	2015	The VEGF mRNA levels in the curcumin, VEGF blocker and curcumin + VEGF blocker groups were all decreased when compared with the model group.	Curcumin	28-36	vascular endothelial growth factor A	Rattus norvegicus	4-8
25435978-5	2015	The VEGF mRNA levels in the curcumin, VEGF blocker and curcumin + VEGF blocker groups were all decreased when compared with the model group.	Curcumin	55-63	vascular endothelial growth factor A	Rattus norvegicus	4-8
25435978-6	2015	In addition, the VEGF mRNA levels in the curcumin + VEGF blocker group were significantly lower compared with the curcumin group (P&lt;0.05).	Curcumin	41-49	vascular endothelial growth factor A	Rattus norvegicus	17-21
25435978-6	2015	In addition, the VEGF mRNA levels in the curcumin + VEGF blocker group were significantly lower compared with the curcumin group (P&lt;0.05).	Curcumin	41-49	vascular endothelial growth factor A	Rattus norvegicus	52-56
25435978-6	2015	In addition, the VEGF mRNA levels in the curcumin + VEGF blocker group were significantly lower compared with the curcumin group (P&lt;0.05).	Curcumin	114-122	vascular endothelial growth factor A	Rattus norvegicus	17-21
25435978-7	2015	The VEGF mRNA levels in the curcumin, VEGF blocker and curcumin + VEGF blocker groups were decreased when compared with the model group (P=0.0001).	Curcumin	28-36	vascular endothelial growth factor A	Rattus norvegicus	4-8
25435978-7	2015	The VEGF mRNA levels in the curcumin, VEGF blocker and curcumin + VEGF blocker groups were decreased when compared with the model group (P=0.0001).	Curcumin	55-63	vascular endothelial growth factor A	Rattus norvegicus	4-8
26016236-11	2015	CONCLUSION: Curcumin derivative B06 exerts a protective effect on kidney in type 2 diabetic rats, reduced expressions of collogen IV and fibronectin, inhibition of the accumulation of extracellular matrix and glomerular mesangial proliferation, and then prevention of renal fibrosis may be the mechanism.	Curcumin	12-20	fibronectin 1	Rattus norvegicus	137-148
25081642-2	2014	The binding of natural products to alpha-synuclein was evaluated by nanopore analysis and caffeine, curcumin, and nicotine all caused large conformational changes which may be related to their known neuroprotective effect in Parkinson"s disease.	Curcumin	100-108	synuclein alpha	Homo sapiens	35-50
25503135-5	2014	LH3 was found to be much more active than cisplatin against the resistant tumor models and greatest synergism in activity was observed when combinations of LH3 with genistein and curcumin were administered as a bolus.	Curcumin	179-187	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	0-3
25240837-7	2014	In addition, in HL60/VCR cells the glucosylceramide synthase activity was diminished by curcumin.	Curcumin	88-96	UDP-glucose ceramide glucosyltransferase	Homo sapiens	35-60
25240837-8	2014	This process was probably due to curcumin-induced down-regulation of P-gp drug transporter, since cyclosporine A, a P-gp blocker, also inhibited the glucosylceramide synthase activity.	Curcumin	33-41	phosphoglycolate phosphatase	Homo sapiens	69-73
25240837-8	2014	This process was probably due to curcumin-induced down-regulation of P-gp drug transporter, since cyclosporine A, a P-gp blocker, also inhibited the glucosylceramide synthase activity.	Curcumin	33-41	phosphoglycolate phosphatase	Homo sapiens	116-120
25240837-8	2014	This process was probably due to curcumin-induced down-regulation of P-gp drug transporter, since cyclosporine A, a P-gp blocker, also inhibited the glucosylceramide synthase activity.	Curcumin	33-41	UDP-glucose ceramide glucosyltransferase	Homo sapiens	149-174
25240837-9	2014	Inhibition of nSMase activity with GW4869 or silencing ofSMPD3 gene encoding nSMase2 reversed the curcumin-induced inhibition of sphingomyelin synthase without affecting the glucosylceramide synthase activity.	Curcumin	98-106	sphingomyelin phosphodiesterase 3	Homo sapiens	77-84
25240837-10	2014	The early ceramide generation by nSMase was indispensable for the later lipid accumulation, modulation of Bax, Bcl-2 and caspase 3 levels, and for reduction of cell viability in curcumin-treated cells, as all these events were inhibited by GW4869 or nSMase2 depletion.	Curcumin	178-186	sphingomyelin phosphodiesterase 3	Homo sapiens	250-257
25554986-9	2014	The elevated proapoptotic proteins caspase 3 and Bax expression in cytoplasm and nucleus of hepatocytes of gentamicin-injected rats were reduced to normal value as a result of thymoquinone and curcumin administration while the lowered expression of antiapoptotic protein Bcl-2 was increased.	Curcumin	193-201	BCL2 associated X, apoptosis regulator	Rattus norvegicus	49-52
25394974-4	2014	Through IL-1 antagonists and substances, such as curcumin IL-1-induced VEGF-A expression and angiogenesis can be blocked; therefore, IL-1-blockade provides an interesting therapy target for chondrosarcoma.	Curcumin	49-57	interleukin 1 alpha	Homo sapiens	8-12
25394974-4	2014	Through IL-1 antagonists and substances, such as curcumin IL-1-induced VEGF-A expression and angiogenesis can be blocked; therefore, IL-1-blockade provides an interesting therapy target for chondrosarcoma.	Curcumin	49-57	interleukin 1 alpha	Homo sapiens	58-62
25394974-4	2014	Through IL-1 antagonists and substances, such as curcumin IL-1-induced VEGF-A expression and angiogenesis can be blocked; therefore, IL-1-blockade provides an interesting therapy target for chondrosarcoma.	Curcumin	49-57	interleukin 1 alpha	Homo sapiens	58-62
25041840-6	2014	In the present study, we reported that curcumin treatment not only attenuated cognitive impairment detected by Morris water maze test, but also inhibited the generation of Abeta investigated by immunohistochemistry in APP/PS1 double transgenic AD mice.	Curcumin	39-47	presenilin 1	Mus musculus	222-225
25041840-7	2014	Moreover, curcumin induced autophagy in the mice, evidenced by LC3 immunofluorescence analysis and western blot assays on LC3.	Curcumin	10-18	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	63-66
25041840-7	2014	Moreover, curcumin induced autophagy in the mice, evidenced by LC3 immunofluorescence analysis and western blot assays on LC3.	Curcumin	10-18	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	122-125
25041840-8	2014	Furthermore, we found that curcumin significantly decreased the expression of Phosphatidylinositol 3-Kinase (PI3K), phosphorylated Akt and rapamycin (mTOR) at protein levels, respectively.	Curcumin	27-35	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	78-107
25041840-8	2014	Furthermore, we found that curcumin significantly decreased the expression of Phosphatidylinositol 3-Kinase (PI3K), phosphorylated Akt and rapamycin (mTOR) at protein levels, respectively.	Curcumin	27-35	mechanistic target of rapamycin kinase	Mus musculus	150-154
25041840-9	2014	Taken together, our data suggests that curcumin inhibits Abeta generation and induces of autophagy by downregulating PI3K/Akt/mTOR signaling pathway, and further shows a neuroprotective effect.	Curcumin	39-47	amyloid beta (A4) precursor protein	Mus musculus	57-62
25041840-9	2014	Taken together, our data suggests that curcumin inhibits Abeta generation and induces of autophagy by downregulating PI3K/Akt/mTOR signaling pathway, and further shows a neuroprotective effect.	Curcumin	39-47	mechanistic target of rapamycin kinase	Mus musculus	126-130
25456852-8	2014	Furthermore, curcumin inhibited HG-induced caveolin-1 (cav-1) Tyr(14) phosphorylation associating with the suppression of stabilization of cav-1 and beta-catenin.	Curcumin	13-21	catenin beta 1	Rattus norvegicus	149-161
25456852-9	2014	CONCLUSIONS: In summary, these findings suggest that curcumin prevents EMT of podocytes, proteinuria, and kidney injury in DN by suppressing the phosphorylation of cav-1, and increasing stabilization of cav-1 and beta-catenin.	Curcumin	53-61	catenin beta 1	Rattus norvegicus	213-225
24706026-0	2014	Protective effect of curcumin on acute airway inflammation of allergic asthma in mice through Notch1-GATA3 signaling pathway.	Curcumin	21-29	notch 1	Mus musculus	94-100
24706026-0	2014	Protective effect of curcumin on acute airway inflammation of allergic asthma in mice through Notch1-GATA3 signaling pathway.	Curcumin	21-29	GATA binding protein 3	Mus musculus	101-106
24706026-2	2014	It has been reported that curcumin attenuates allergic airway inflammation in mice through inhibiting NF-kappaB and its downstream transcription factor GATA3.	Curcumin	26-34	GATA binding protein 3	Mus musculus	152-157
24706026-3	2014	It also has been proved the antineoplastic effect of curcumin through down-regulating Notch1 receptor and its downstream nuclear transcription factor NF-kappaB levels.	Curcumin	53-61	notch 1	Mus musculus	86-92
24706026-9	2014	Curcumin pretreatment improved the airway inflammatory cells infiltration and reversed the increasing levels of Notch1/2 receptors and GATA3.	Curcumin	0-8	notch 1	Mus musculus	112-118
24706026-9	2014	Curcumin pretreatment improved the airway inflammatory cells infiltration and reversed the increasing levels of Notch1/2 receptors and GATA3.	Curcumin	0-8	GATA binding protein 3	Mus musculus	135-140
25282128-9	2014	Curcumin reduced the mRNA and protein expression of intracellular adhesion molecule-1, vascular cell adhesion molecule-1, P-selectin, and monocyte chemotactic protein-1, and it inhibited HCD-induced up-regulation of MMP-1, MMP-2, and MMP-9.	Curcumin	0-8	vascular cell adhesion protein 1	Oryctolagus cuniculus	87-120
25282128-9	2014	Curcumin reduced the mRNA and protein expression of intracellular adhesion molecule-1, vascular cell adhesion molecule-1, P-selectin, and monocyte chemotactic protein-1, and it inhibited HCD-induced up-regulation of MMP-1, MMP-2, and MMP-9.	Curcumin	0-8	P-selectin	Oryctolagus cuniculus	122-132
25282128-9	2014	Curcumin reduced the mRNA and protein expression of intracellular adhesion molecule-1, vascular cell adhesion molecule-1, P-selectin, and monocyte chemotactic protein-1, and it inhibited HCD-induced up-regulation of MMP-1, MMP-2, and MMP-9.	Curcumin	0-8	72 kDa type IV collagenase	Oryctolagus cuniculus	223-228
25241044-0	2014	Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages.	Curcumin	0-8	basigin (Ok blood group)	Homo sapiens	18-25
25241044-4	2014	The purpose of our study was to investigate the molecular mechanisms by which curcumin affects MMP-9, MMP13 and EMMPRIN in PMA (phorbol 12-myristate 13-acetate) induced macrophages.	Curcumin	78-86	basigin (Ok blood group)	Homo sapiens	112-119
25241044-6	2014	In the present study, the exposure to curcumin resulted in attenuated JNK, p38, and ERK activation and decreased expression of MMP-9, MMP-13 and EMMPRIN in PMA induced macrophages.	Curcumin	38-46	basigin (Ok blood group)	Homo sapiens	145-152
25241044-8	2014	Furthermore, curcumin reversed PMA stimulated PKC activation and suppressed the chronic activation of AMPK, which in turn reduced the expression of MMP-9, MMP-13 and EMMPRIN.	Curcumin	13-21	basigin (Ok blood group)	Homo sapiens	166-173
25241044-9	2014	Therefore, it is suggested that curcumin by inhibiting AMPK-MAPK (mitogen activated protein kinase) and PKC pathway may led to down-regulated EMMPRIN, MMP-9 and MMP-13 expression in PMA-induced THP-1 cells.	Curcumin	32-40	basigin (Ok blood group)	Homo sapiens	142-149
25400722-8	2014	Curcumin also inhibited SCC-25 cells invasion and downregulated MMP-2, MMP-9, uPA and uPAR expression.	Curcumin	0-8	plasminogen activator, urokinase receptor	Homo sapiens	86-90
24910117-5	2014	Western blot assay data demonstrated that curcumin inhibited phosphorylation of PI3K and Akt signaling pathways and subsequently attenuated MMP1/7 and COX-2 protein expressions in FTC133.	Curcumin	42-50	matrix metallopeptidase 17	Homo sapiens	140-146
24857828-9	2014	The expression of DHAND and EHAND is significantly down-regulated and up-regulated in the groups treated with curcumin and SAHA.	Curcumin	110-118	heart and neural crest derivatives expressed 2	Mus musculus	18-23
24857828-10	2014	Furthermore, our results from ChIP assays have shown that the histone H3K14ac connects with the DHAND and EHAND genes are significantly inhibited by curcumin and simulated by SAHA.	Curcumin	149-157	heart and neural crest derivatives expressed 2	Mus musculus	96-101
24293118-0	2014	MiR-21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non-small cell lung cancer A549 cells.	Curcumin	47-55	microRNA 21	Homo sapiens	0-6
24293118-0	2014	MiR-21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non-small cell lung cancer A549 cells.	Curcumin	47-55	phosphatase and tensin homolog	Homo sapiens	69-73
24293118-4	2014	The expression of microRNA-21 in curcumin-treated A549 cells was measured by quantitative real-time polymerase chain reaction assay.	Curcumin	33-41	microRNA 21	Homo sapiens	18-29
24293118-6	2014	Transfection of A549 cells with microRNA-21 mimic or PTEN small interfering RNA was performed to modulate the expression of microRNA-21 and PTEN under the treatment of curcumin.	Curcumin	168-176	microRNA 21	Homo sapiens	32-43
24293118-6	2014	Transfection of A549 cells with microRNA-21 mimic or PTEN small interfering RNA was performed to modulate the expression of microRNA-21 and PTEN under the treatment of curcumin.	Curcumin	168-176	phosphatase and tensin homolog	Homo sapiens	53-57
24293118-6	2014	Transfection of A549 cells with microRNA-21 mimic or PTEN small interfering RNA was performed to modulate the expression of microRNA-21 and PTEN under the treatment of curcumin.	Curcumin	168-176	microRNA 21	Homo sapiens	124-135
24293118-6	2014	Transfection of A549 cells with microRNA-21 mimic or PTEN small interfering RNA was performed to modulate the expression of microRNA-21 and PTEN under the treatment of curcumin.	Curcumin	168-176	phosphatase and tensin homolog	Homo sapiens	140-144
24293118-8	2014	Curcumin treatment produced a dose-dependent and significant (P &lt; 0.05) suppression of microRNA-21 expression, compared to untreated A549 cells.	Curcumin	0-8	microRNA 21	Homo sapiens	90-101
24293118-9	2014	Moreover, the protein level of PTEN, a putative target of microRNA-21, was significantly elevated in curcumin-treated A549 cells, as determined by Western blot analysis.	Curcumin	101-109	phosphatase and tensin homolog	Homo sapiens	31-35
24293118-9	2014	Moreover, the protein level of PTEN, a putative target of microRNA-21, was significantly elevated in curcumin-treated A549 cells, as determined by Western blot analysis.	Curcumin	101-109	microRNA 21	Homo sapiens	58-69
24293118-10	2014	Transfection of A549 cells with microRNA-21 mimic or PTEN small interfering RNA significantly (P &lt; 0.05) reversed the growth suppression and apoptosis induction by curcumin, compared to corresponding controls.	Curcumin	167-175	microRNA 21	Homo sapiens	32-43
24293118-10	2014	Transfection of A549 cells with microRNA-21 mimic or PTEN small interfering RNA significantly (P &lt; 0.05) reversed the growth suppression and apoptosis induction by curcumin, compared to corresponding controls.	Curcumin	167-175	phosphatase and tensin homolog	Homo sapiens	53-57
24293118-11	2014	CONCLUSIONS: Our data suggest a novel molecular mechanism in which inhibition of microRNA-21 and upregulation of PTEN mediate the anticancer activities of curcumin in NSCLC cells.	Curcumin	155-163	microRNA 21	Homo sapiens	81-92
24293118-11	2014	CONCLUSIONS: Our data suggest a novel molecular mechanism in which inhibition of microRNA-21 and upregulation of PTEN mediate the anticancer activities of curcumin in NSCLC cells.	Curcumin	155-163	phosphatase and tensin homolog	Homo sapiens	113-117
24142484-4	2014	Expression of exogenous p50 and p65 subunits of NF-kappaB conferred partial protection on transfected GL261 cells against curcumin insult, indicating that NF-kappaB played a key role in protecting glioblastoma cells.	Curcumin	122-130	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	32-35
24835302-8	2014	Western blot analysis showed that the expressions of IkB, nuclear p65, cyclooxygenase 2 (COX-2) and p-ERK1/2 were down-regulated by curcumin in vitro.	Curcumin	132-140	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	66-69
24835302-11	2014	Curcumin inhibition of COX-2, p65 expression and ERK1/2 activity in NSCLC cells was associated with decreased survival and increased induction of apoptosis.	Curcumin	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	30-33
24944632-6	2014	In conclusion, these results indicated that co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression of ApoAI, CYP7A1, LCAT and LDLR, providing a promising combination for the treatment of HLP.	Curcumin	65-73	apolipoprotein A1	Rattus norvegicus	194-199
24944632-6	2014	In conclusion, these results indicated that co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression of ApoAI, CYP7A1, LCAT and LDLR, providing a promising combination for the treatment of HLP.	Curcumin	135-143	apolipoprotein A1	Rattus norvegicus	194-199
24777807-7	2014	Consequently, we found that curcumin pretreatment enabled improving neurological deficit, diminishing infarct volume and increasing the number of NeuN-labeled neurons in the I/R rats.	Curcumin	28-36	RNA binding fox-1 homolog 3	Rattus norvegicus	146-150
24780320-8	2014	KEY FINDINGS: Exosomes derived from curcumin-treated (primed) cells (CUR-EXO) alleviated oxidative stress, tight junctions (ZO-1, claudin-5, occludin), adherent junction (VE-cadherin) proteins and EC layer permeability induced during EC damage due to high homocysteine levels (hyperhomocysteinemia).	Curcumin	36-44	5'-3' exoribonuclease 1	Mus musculus	73-76
24932681-7	2014	Curcumin treatment resulted in activation of antioxidant enzyme super oxide dismutase and down regulation of ROS level as well as activity of ROS producing enzyme NADPH:oxidase, expression of stress activated genes HIF-1alpha, cMyc and LDH activity towards normal level.	Curcumin	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	215-225
25200041-1	2014	OBJECTIVE: By using the cell wall component of Mycobacterium tuberculosis 19 000 lipoprotein (P19) and curcumin (CUR) acting on the human macrophage cell line WBC264-9C, and by the blocking of the p38 mitogen-activated protein kinases (p38 MAPK) signaling pathway, we wanted to investigate the effect of curcumin on P19-induced inflammatory responses and apoptosis in human macrophages and the potential underlying molecular mechanisms.	Curcumin	304-312	interleukin 23 subunit alpha	Homo sapiens	94-97
25200041-12	2014	Low concentration of curcumin may play a protective effect against P19-induced immune responses by inhibiting the p38 MAPK pathway in macrophages.	Curcumin	21-29	interleukin 23 subunit alpha	Homo sapiens	67-70
24755072-6	2014	Furthermore, we found that application of curcumin activated the expression of SIRT1 and subsequently decreased the expression of Bax in the presence of Abeta25-35.	Curcumin	42-50	BCL2 associated X, apoptosis regulator	Rattus norvegicus	130-133
24665465-5	2014	The changes in the expression level of cyt c and caspase-9 in the cytosol upon curcumin-induced apoptosis were detected by using the proposed method, and also the influence of different concentrations and incubation times of curcumin-induced Hela cells was investigated.	Curcumin	79-87	caspase 9	Homo sapiens	49-58
24665465-5	2014	The changes in the expression level of cyt c and caspase-9 in the cytosol upon curcumin-induced apoptosis were detected by using the proposed method, and also the influence of different concentrations and incubation times of curcumin-induced Hela cells was investigated.	Curcumin	225-233	caspase 9	Homo sapiens	49-58
24830678-7	2014	We compared curcumin with hemin, an agonist of heme oxygenase-1 (HO-1), which significantly affects only one KEGG pathway, porphyrin and chlorophyll metabolism (adjusted p = 1.5x10-5).	Curcumin	12-20	heme oxygenase 1	Homo sapiens	47-63
24830678-7	2014	We compared curcumin with hemin, an agonist of heme oxygenase-1 (HO-1), which significantly affects only one KEGG pathway, porphyrin and chlorophyll metabolism (adjusted p = 1.5x10-5).	Curcumin	12-20	heme oxygenase 1	Homo sapiens	65-69
24830678-10	2014	Selective inhibition of HO-1 completely blocked the action of hemin but not that of curcumin, suggesting simultaneous multi-pathway intervention by curcumin.	Curcumin	148-156	heme oxygenase 1	Homo sapiens	24-28
24463298-4	2014	A number of studies have suggested that curcumin has the potential to target CSCs through regulation of CSC self-renewal pathways (Wnt/beta-catenin, Notch, sonic hedgehog) and specific microRNAs involved in acquisition of epithelial-mesenchymal transition (EMT).	Curcumin	40-48	catenin beta 1	Homo sapiens	135-147
24463298-4	2014	A number of studies have suggested that curcumin has the potential to target CSCs through regulation of CSC self-renewal pathways (Wnt/beta-catenin, Notch, sonic hedgehog) and specific microRNAs involved in acquisition of epithelial-mesenchymal transition (EMT).	Curcumin	40-48	sonic hedgehog signaling molecule	Homo sapiens	156-170
24669820-2	2014	In the current study, we tested the hypothesis that curcumin, a phytochemical compound with potent anti-inflammatory properties that is extracted from the rhizome Curcuma longa, alleviates acute inflammatory injury mediated by TLR4 following TBI.	Curcumin	52-60	toll like receptor 4	Homo sapiens	227-231
24669820-15	2014	CONCLUSIONS: Our results suggest that post-injury, curcumin administration may improve patient outcome by reducing acute activation of microglia/macrophages and neuronal apoptosis through a mechanism involving the TLR4/MyD88/NF-kappaB signaling pathway in microglia/macrophages in TBI.	Curcumin	51-59	toll like receptor 4	Homo sapiens	214-218
24662163-7	2014	The vascular protective effect of curcumin in Cd exposed mice is associated with up-regulation of endothelial nitric oxide synthase (eNOS) protein, restoration of glutathione redox ratio and alleviation of oxidative stress as indicated by decreasing superoxide production in the aortic tissues and reducing plasma malondialdehyde, plasma protein carbonyls, and urinary nitrate/nitrite levels.	Curcumin	34-42	nitric oxide synthase 3, endothelial cell	Mus musculus	98-131
24662163-7	2014	The vascular protective effect of curcumin in Cd exposed mice is associated with up-regulation of endothelial nitric oxide synthase (eNOS) protein, restoration of glutathione redox ratio and alleviation of oxidative stress as indicated by decreasing superoxide production in the aortic tissues and reducing plasma malondialdehyde, plasma protein carbonyls, and urinary nitrate/nitrite levels.	Curcumin	34-42	nitric oxide synthase 3, endothelial cell	Mus musculus	133-137
24309154-0	2014	Inhibition of specificity protein 1 by dibenzylideneacetone, a curcumin analogue, induces apoptosis in mucoepidermoid carcinomas and tumor xenografts through Bim and truncated Bid.	Curcumin	63-71	trans-acting transcription factor 1	Mus musculus	14-35
24749345-9	2014	CONCLUSION: Curcumin may partly prevent the lung injury induced by prolonged hyperoxia exposure in neonatal rats probably via modulating the expressions of IL-6, IL-10 and IGF-I in serum and lung tissue.	Curcumin	12-20	interleukin 10	Rattus norvegicus	162-167
24316441-4	2014	Curcumin treatment greatly reduced the astrogliosis in SCI mice and significantly decreased the expression of IL-1beta and NO, as well as the number of Iba1(+) inflammatory cells at the lesion site.	Curcumin	0-8	induction of brown adipocytes 1	Mus musculus	152-156
24467380-0	2014	Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer"s disease model via canonical Wnt/beta-catenin pathway.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	143-155
24467380-7	2014	Curcumin nanoparticles increase neuronal differentiation by activating the Wnt/beta-catenin pathway, involved in regulation of neurogenesis.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	79-91
24467380-11	2014	In silico molecular docking studies suggest that curcumin interacts with Wif-1, Dkk, and GSK-3beta.	Curcumin	49-57	Wnt inhibitory factor 1	Rattus norvegicus	73-78
24467380-12	2014	These results suggest that curcumin nanoparticles induce adult neurogenesis through activation of the canonical Wnt/beta-catenin pathway and may offer a therapeutic approach to treating neurodegenerative diseases such as AD, by enhancing a brain self-repair mechanism.	Curcumin	27-35	catenin beta 1	Rattus norvegicus	116-128
24060216-1	2014	Curcumin has been reported to inhibit insulin signaling and translocation of GLUT4 to the cell surface in 3T3-L1 adipocytes.	Curcumin	0-8	solute carrier family 2 member 4	Rattus norvegicus	77-82
24531649-0	2014	Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells.	Curcumin	12-20	microRNA 145	Homo sapiens	74-81
24531649-15	2014	Dendrosomal curcumin significantly decreased the relative expression of OCT4A, OCT4B1, SOX-2, and Nanog along with noticeable overexpression of miR-145 as the upstream regulator.	Curcumin	12-20	microRNA 145	Homo sapiens	144-151
24531649-16	2014	This suggests that dendrosomal curcumin reduces the proliferation of U87MG cells through the downregulation of OCT4 (octamer binding protein 4) variants and SOX-2 (SRY [sex determining region Y]-box 2) in an miR-145-dependent manner.	Curcumin	31-39	POU class 5 homeobox 1	Homo sapiens	111-115
24531649-16	2014	This suggests that dendrosomal curcumin reduces the proliferation of U87MG cells through the downregulation of OCT4 (octamer binding protein 4) variants and SOX-2 (SRY [sex determining region Y]-box 2) in an miR-145-dependent manner.	Curcumin	31-39	POU class 5 homeobox 1	Homo sapiens	117-142
24531649-16	2014	This suggests that dendrosomal curcumin reduces the proliferation of U87MG cells through the downregulation of OCT4 (octamer binding protein 4) variants and SOX-2 (SRY [sex determining region Y]-box 2) in an miR-145-dependent manner.	Curcumin	31-39	microRNA 145	Homo sapiens	208-215
24935377-0	2014	Influence of curcumin on HOTAIR-mediated migration of human renal cell carcinoma cells.	Curcumin	13-21	HOX transcript antisense RNA	Homo sapiens	25-31
24935377-1	2014	BACKGROUND: This study investigated the influence of curcumin on HOX transcript antisense RNA (HOTAIR)- mediated migration of cultured renal cell carcinoma (RCC) cells.	Curcumin	53-61	HOX transcript antisense RNA	Homo sapiens	95-101
24935377-8	2014	CONCLUSIONS: HOTAIR expression is correlated with the migration of RCC cells, and HOTAIR may be involved in the curcumin-induced inhibition of RCC metastasis.	Curcumin	112-120	HOX transcript antisense RNA	Homo sapiens	82-88
24840575-0	2014	Biological evaluation and 3D-QSAR studies of curcumin analogues as aldehyde dehydrogenase 1 inhibitors.	Curcumin	45-53	aldehyde dehydrogenase 1 family member A1	Homo sapiens	67-91
24840575-2	2014	In this paper, the inhibitory activity, mechanism mode, molecular docking and 3D-QSAR (three-dimensional quantitative structure activity relationship) of curcumin analogues (CAs) against ALDH1 were studied.	Curcumin	154-162	aldehyde dehydrogenase 1 family member A1	Homo sapiens	187-192
24840575-3	2014	Results demonstrated that curcumin and CAs possessed potent inhibitory activity against ALDH1, and the CAs compound with ortho di-hydroxyl groups showed the most potent inhibitory activity.	Curcumin	26-34	aldehyde dehydrogenase 1 family member A1	Homo sapiens	88-93
24689857-6	2014	In addition, mixture 1 and curcumin (2) showed activity on cell cycle arrest at the G0/G1 phase and decreased the FLT3 and STAT5A protein levels in a dose-dependent manner.	Curcumin	27-35	signal transducer and activator of transcription 5A	Homo sapiens	123-129
24743574-15	2014	Taken together, combined treatment with NVP-BEZ235 and curcumin induces apoptosis through p53-dependent Bcl-2 mRNA down-regulation at the transcriptional level and Mcl-1 protein down-regulation at the post-transcriptional level.	Curcumin	55-63	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	164-169
33934954-8	2021	The dose-responses analysis indicated that curcumin/turmeric supplementation resulted in IL-1 and IL-8 alteration in a non-linear model.	Curcumin	43-51	interleukin 1 alpha	Homo sapiens	89-93
24705375-9	2014	Interestingly, combined treatment of curcumin and resveratrol to BP treated animals resulted in a significant decrease in p53 hyper-phosphorylation, 14C glucose uptakes/turnover and 3H-thymidine uptake in the BP treated mice.	Curcumin	37-45	transformation related protein 53, pseudogene	Mus musculus	122-125
33934954-10	2021	Curcumin could have a beneficial effect in reducing the proinflammatory cytokines IL-1 and TNF-alpha, but not IL-6 and IL-8 levels.	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	82-86
23666561-0	2014	Curcumin targets the AKT-mTOR pathway for uterine leiomyosarcoma tumor growth suppression.	Curcumin	0-8	mechanistic target of rapamycin kinase	Mus musculus	25-29
25254215-0	2014	Curcumin, a natural antioxidant, acts as a noncompetitive inhibitor of human RNase L in presence of its cofactor 2-5A in vitro.	Curcumin	0-8	ribonuclease L	Homo sapiens	77-84
33980059-0	2021	Curcumin Can Activate the Nrf2/HO-1 Signaling Pathway and Scavenge Free Radicals in Spinal Cord Injury Treatment.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	31-35
25254215-3	2014	Here, we show that curcumin, a natural plant-derived anti-inflammatory active principle, inhibits RNase L activity; hence, it may be exploited for therapeutic interventions in case of pathological situations associated with excess activation of RNase L.	Curcumin	19-27	ribonuclease L	Homo sapiens	98-105
25254215-3	2014	Here, we show that curcumin, a natural plant-derived anti-inflammatory active principle, inhibits RNase L activity; hence, it may be exploited for therapeutic interventions in case of pathological situations associated with excess activation of RNase L.	Curcumin	19-27	ribonuclease L	Homo sapiens	245-252
24645646-13	2014	Western blot analysis revealed that curcumin and naloxone restored the expression of MFG-E8 but had no effect on TLR4 and cytosolic STAT3.	Curcumin	36-44	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	85-91
24645646-15	2014	CONCLUSIONS: This study indicates that curcumin ameliorates the depressed MFG-E8 expression and the attenuated phagocytic ability of EMF-exposed N9 cells, which is attributable to the inhibition of the pro-inflammatory response through the NF-kappaB and STAT3 pathways.	Curcumin	39-47	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	74-80
24313805-0	2014	Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	0-8	Uncharacterized protein	Caenorhabditis elegans	109-114
24313805-0	2014	Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	0-8	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	131-136
24313805-6	2014	Lastly, our findings from the mechanistic study in this investigation suggest that the antioxidative effect of curcumin is mediated via regulation of age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	111-119	Uncharacterized protein	Caenorhabditis elegans	171-176
24313805-6	2014	Lastly, our findings from the mechanistic study in this investigation suggest that the antioxidative effect of curcumin is mediated via regulation of age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	111-119	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	193-198
33980059-6	2021	In this review, we analyze the role of curcumin in activating Nrf2/HO-1 and scavenging free radicals to repair SCI.	Curcumin	39-47	heme oxygenase 1	Homo sapiens	67-71
34001703-0	2021	Curcumin suppresses renal carcinoma tumorigenesis by regulating circ-FNDC3B/miR-138-5p/IGF2 axis.	Curcumin	0-8	fibronectin type III domain containing 3B	Homo sapiens	69-75
23807180-1	2014	We report results on the use of organically modified silica nanoparticles (SiNp) as a vehicle for the delivery of curcumin in human oral cancer cells for improvement of uptake and phototoxicity.	Curcumin	114-122	embryonal Fyn-associated substrate	Homo sapiens	75-79
23807180-2	2014	Nanoformulated drug (curcumin-SiNp complex) was prepared by postloading curcumin in SiNp, and the complex was soluble in aqueous solution.	Curcumin	21-29	embryonal Fyn-associated substrate	Homo sapiens	30-34
23807180-2	2014	Nanoformulated drug (curcumin-SiNp complex) was prepared by postloading curcumin in SiNp, and the complex was soluble in aqueous solution.	Curcumin	21-29	embryonal Fyn-associated substrate	Homo sapiens	84-88
23807180-3	2014	Cellular uptake studied by fluorescence microscopy and spectroscopy showed that curcumin accumulation was higher when cells were incubated with curcumin-SiNp complex as against free curcumin.	Curcumin	80-88	embryonal Fyn-associated substrate	Homo sapiens	153-157
23807180-3	2014	Cellular uptake studied by fluorescence microscopy and spectroscopy showed that curcumin accumulation was higher when cells were incubated with curcumin-SiNp complex as against free curcumin.	Curcumin	144-152	embryonal Fyn-associated substrate	Homo sapiens	153-157
24749345-9	2014	CONCLUSION: Curcumin may partly prevent the lung injury induced by prolonged hyperoxia exposure in neonatal rats probably via modulating the expressions of IL-6, IL-10 and IGF-I in serum and lung tissue.	Curcumin	12-20	insulin-like growth factor 1	Rattus norvegicus	172-177
24275249-0	2014	Functionalized curcumin analogs as potent modulators of the Wnt/beta-catenin signaling pathway.	Curcumin	15-23	catenin beta 1	Homo sapiens	64-76
24275249-2	2014	In our earlier work we have investigated the therapeutic potential of curcumin as an anti-invasive agent in osteosarcoma by its ability to regulate the Wnt/beta-catenin signaling pathway.	Curcumin	70-78	catenin beta 1	Homo sapiens	156-168
24275249-5	2014	We synthesized a total of five series consisting of 43 curcumin analogs and screened in HEK293T cells for inhibition of beta-catenin transcriptional activity.	Curcumin	55-63	catenin beta 1	Homo sapiens	120-132
24138392-6	2014	In the present study, curcumin treatment significantly resulted in the inhibition of cell proliferation and an increase in the apoptosis rate through the up-regulation of PTEN associated with a decreased DNA methylation level.	Curcumin	22-30	phosphatase and tensin homolog	Homo sapiens	171-175
24138392-7	2014	Only DNA methyltransferase 3b (DNMT3b) was reduced in vivo and in vitro after curcumin treatment.	Curcumin	78-86	DNA methyltransferase 3 beta	Homo sapiens	5-29
25272063-7	2014	Overexpression of HSPs (27, 70, 90), HSF1, and HDAC6 in leukemia cells were down-regulated by curcumin, and the effects on HSPs 27and 70 were less than that on HSP 90.	Curcumin	94-102	heat shock protein 90 alpha family class A member 1	Homo sapiens	160-166
24188406-0	2014	Curcumin attenuates amyloid-beta-induced tau hyperphosphorylation in human neuroblastoma SH-SY5Y cells involving PTEN/Akt/GSK-3beta signaling pathway.	Curcumin	0-8	phosphatase and tensin homolog	Homo sapiens	113-117
34001703-0	2021	Curcumin suppresses renal carcinoma tumorigenesis by regulating circ-FNDC3B/miR-138-5p/IGF2 axis.	Curcumin	0-8	insulin like growth factor 2	Homo sapiens	87-91
24188406-10	2014	Curcumin depresses Abeta-induced up-regulation of PTEN induced by Abeta.	Curcumin	0-8	phosphatase and tensin homolog	Homo sapiens	50-54
24188406-11	2014	These results imply that curcumin inhibits Abeta-induced tau hyperphosphorylation involving PTEN/Akt/GSK-3beta pathway.	Curcumin	25-33	phosphatase and tensin homolog	Homo sapiens	92-96
34001703-11	2021	circ-FNDC3B overexpression or miR-138-5p knockdown weakened the influence of curcumin.	Curcumin	77-85	fibronectin type III domain containing 3B	Homo sapiens	5-11
24935585-5	2014	Apoptosis triggered by curcumin was visualized using Annexin V-FITC/7- AAD staining.	Curcumin	23-31	annexin A5	Homo sapiens	53-62
34001703-14	2021	Curcumin decreased xenograft tumor growth via reducing circ-FNDC3B in vivo.	Curcumin	0-8	fibronectin type III domain containing 3B	Homo sapiens	60-66
34001703-15	2021	Curcumin suppressed renal carcinoma tumorigenesis in vitro and in vivo via regulating circ-FNDC3B/miR-138-5p/IGF2 axis, proposing new insight into renal carcinoma tumorigenesis.	Curcumin	0-8	fibronectin type III domain containing 3B	Homo sapiens	91-97
24211270-10	2014	Additionally, treatment with a chemopreventive compound, curcumin, induced HO-1 expression accompanied with reduction of HSP90 client protein expression.	Curcumin	57-65	heat shock protein 90 alpha family class A member 1	Homo sapiens	121-126
34001703-15	2021	Curcumin suppressed renal carcinoma tumorigenesis in vitro and in vivo via regulating circ-FNDC3B/miR-138-5p/IGF2 axis, proposing new insight into renal carcinoma tumorigenesis.	Curcumin	0-8	insulin like growth factor 2	Homo sapiens	109-113
33880847-8	2021	Thus, m6 A-dependent TRAF4 expression upregulation by ALKBH5 and YTHDF1 contributes to curcumin-induced obesity prevention.	Curcumin	87-95	alkB homolog 5, RNA demethylase	Mus musculus	54-60
24364912-9	2013	In addition, curcumin treated rats showed significant increase in gene expression of IGF-1, Bcl2, SOD and GST compare to non diabetic and diabetic untreated rats.	Curcumin	13-21	insulin-like growth factor 1	Rattus norvegicus	85-90
24364912-10	2013	CONCLUSION: Curcumin was antidiabetic therapy, induced hypoglycemia by up-regulation of IGF-1 gene and ameliorate the diabetes induced oxidative stress via increasing the availability of GSH, increasing the activities and gene expression of antioxidant enzymes and Bcl2.	Curcumin	12-20	insulin-like growth factor 1	Rattus norvegicus	88-93
24606473-3	2014	It was further intended to investigate whether curcumin could sensitize the cells towards cisplatin induced cell killing by modulation of multi drug resistant proteins like MRP1 and Pgp1.	Curcumin	47-55	MDM4 regulator of p53	Homo sapiens	173-177
24606473-6	2014	Cisplatin resistance in SiHaR due to over-expression of MRP1 and Pgp1 was overcome by curcumin.	Curcumin	86-94	MDM4 regulator of p53	Homo sapiens	56-60
24606473-9	2014	Suppression of MRP1 and Pgp1 by curcumin resulted in sensitization of cervical cancer cells, lowering the chemotherapeutic dose of the drug cisplatin.	Curcumin	32-40	MDM4 regulator of p53	Homo sapiens	15-19
24716979-0	2014	Curcumin inhibits MHCC97H liver cancer cells by activating ROS/TLR-4/caspase signaling pathway.	Curcumin	0-8	toll like receptor 4	Homo sapiens	63-68
24716979-4	2014	These results showed that as an prooxidant, curcumin exerts anti-cancer effects by inducing apoptosis via the TLR-4/MyD-88 signaling pathway.	Curcumin	44-52	toll like receptor 4	Homo sapiens	110-115
33926561-0	2021	Curcumin-primed human BMSC-derived extracellular vesicles reverse IL-1beta-induced catabolic responses of OA chondrocytes by upregulating miR-126-3p.	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	66-74
24647337-0	2014	Effects of curcumin analogues for inhibiting human prostate cancer cells and the growth of human PC-3 prostate xenografts in immunodeficient mice.	Curcumin	11-19	proprotein convertase subtilisin/kexin type 1	Homo sapiens	97-101
33926561-5	2021	Here, we evaluated modulatory effects of curcumin-primed human (h)BMSC-derived EVs (Cur-EVs) on IL-1beta stimulated human osteoarthritic chondrocytes (OA-CH).	Curcumin	41-49	interleukin 1 alpha	Homo sapiens	96-104
33895199-2	2021	In this study, a smart oxidative stress-responsive electrospun polyester membrane (EPM) was fabricated as both physical barrier and reservoir of curcumin/celecoxib (CUR/CEL) to prevent peritendinous adhesion.	Curcumin	145-153	carboxyl ester lipase	Homo sapiens	169-172
25157362-0	2014	Synthesis, characterization and in vitro anticancer activity of C-5 curcumin analogues with potential to inhibit TNF-alpha-induced NF-kappaB activation.	Curcumin	68-76	complement C5	Homo sapiens	64-67
25157362-1	2014	In a search of new compounds active against cancer, synthesis of a series of C-5 curcumin analogues was carried out.	Curcumin	81-89	complement C5	Homo sapiens	77-80
24592391-0	2014	Human pharmacokinetics of high dose oral curcumin and its effect on heme oxygenase-1 expression in healthy male subjects.	Curcumin	41-49	heme oxygenase 1	Homo sapiens	68-84
24592391-3	2014	We investigated the inducibility of HO-1 by orally administered curcumin in healthy male subjects and its correlation with the GT length polymorphism.	Curcumin	64-72	heme oxygenase 1	Homo sapiens	36-40
33894206-6	2021	The anti-cancer effects of curcumin are principally attributed to the regulation of several cellular signaling pathways, including MAPK/PI3K/Akt, Wnt/beta-catenin, JAK/STAT, and NF-kB signaling pathways.	Curcumin	27-35	catenin beta 1	Homo sapiens	150-162
23888319-3	2014	Our results found that curcumin inhibited cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1.	Curcumin	23-31	interferon alpha inducible protein 27	Homo sapiens	144-147
23848205-9	2013	Since curcumin is known to inhibit the cyclin D1-dependent G1/S-phase kinase CDK4 and the cyclin B-dependent G2/M-phase kinase CDK1 that catalyze phosphorylation-mediated inactivation of Rb, our results indicate that SunC containing a lower dose of sunitinib would be effective in restoring the tumor suppressor activity of Rb, thereby truncating cell cycle and triggering cell death.	Curcumin	6-14	cyclin dependent kinase 1	Homo sapiens	127-131
24165291-10	2013	CONCLUSION: This study shows that curcumin holds a great promise for SHH/GLI1 targeted therapy against gliomas.	Curcumin	34-42	sonic hedgehog	Mus musculus	69-72
33907454-9	2021	Moreover, curcumin treatment increased the number of newly born immature (BrdU/NeuN) and newly generated mature neurons (BrdU/DCX).	Curcumin	10-18	RNA binding fox-1 homolog 3	Rattus norvegicus	79-83
24157330-6	2013	Using an antibody array approach, curcumin was found to inhibit LPS-induced cytokine production, including MIP-1alpha, MIP-1beta, IL-6, IL-8 (CXCL-8) and GRO-alpha.	Curcumin	34-42	C-C motif chemokine ligand 3	Homo sapiens	107-117
24157330-6	2013	Using an antibody array approach, curcumin was found to inhibit LPS-induced cytokine production, including MIP-1alpha, MIP-1beta, IL-6, IL-8 (CXCL-8) and GRO-alpha.	Curcumin	34-42	C-C motif chemokine ligand 4	Homo sapiens	119-128
24157330-10	2013	As assessed by a murine antibody array approach, curcumin was found to decrease the local production of several cytokines/chemokines induced by LPS, including, but not limit to, MIP-1alpha and MIP-1beta.	Curcumin	49-57	C-C motif chemokine ligand 3	Homo sapiens	178-188
24157330-10	2013	As assessed by a murine antibody array approach, curcumin was found to decrease the local production of several cytokines/chemokines induced by LPS, including, but not limit to, MIP-1alpha and MIP-1beta.	Curcumin	49-57	C-C motif chemokine ligand 4	Homo sapiens	193-202
33881968-10	2021	Curcumin down-regulates SHH pathways, epigallocatechin-3-gallate regulates the Notch pathway, inhibits TGFbeta1/SMAD signalling, resveratrol regulates the Wnt/beta-catenin pathway, and carnosic acid-induced apoptosis in colon cancer cell via JAK2/STAT3 signalling pathway.	Curcumin	0-8	sonic hedgehog signaling molecule	Homo sapiens	24-27
24402822-0	2013	3D QSAR and pharmacophore study of curcuminoids and curcumin analogs: interaction with thioredoxin reductase.	Curcumin	35-43	peroxiredoxin 5	Homo sapiens	87-108
24402822-1	2013	Curcumin is the yellow pigment of Curcuma longa that irreversibly inhibits the activity of thioredoxin reductase (TrxR) and forms adduct.	Curcumin	0-8	peroxiredoxin 5	Homo sapiens	91-112
24402822-1	2013	Curcumin is the yellow pigment of Curcuma longa that irreversibly inhibits the activity of thioredoxin reductase (TrxR) and forms adduct.	Curcumin	0-8	peroxiredoxin 5	Homo sapiens	114-118
24402822-4	2013	Hence TrxR is a promising target for curcumin based therapy.	Curcumin	37-45	peroxiredoxin 5	Homo sapiens	6-10
24402822-5	2013	Binding site of TrxR for curcumin is at the interface of homodimers.	Curcumin	25-33	peroxiredoxin 5	Homo sapiens	16-20
33875681-3	2021	Here, we observed that curcumin induced the expression of genes downstream of Nrf2 such as HO-1, NQO1, and GST-mu1 in neuronal cells, and increased the level of Nrf2 protein.	Curcumin	23-31	heme oxygenase 1	Homo sapiens	91-95
24134840-0	2013	MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells.	Curcumin	19-27	macrophage stimulating 1	Homo sapiens	0-4
33857519-4	2021	Herein, the self-assembly of chitosan and fucoidan which could encapsulate curcumin was developed to form the multi-stimuli-responsive nanocarriers, and their pathological pH- and P-selectin-responsive aspects were characterized.	Curcumin	75-83	selectin P	Homo sapiens	180-190
33857519-5	2021	Through intranasal delivery to the brain, these curcumin-containing chitosan/fucoidan nanocarriers with dual pH-/P-selectin-targeting properties to the brain lesions improved drug delivery, distribution, and accumulation in the inflammatory brain lesions as evidenced by an augmented inhibitory effect against brain inflammation.	Curcumin	48-56	selectin P	Homo sapiens	113-123
24134840-1	2013	Different groups including ours have shown that curcumin induces melanoma cell apoptosis, here we focused the role of mammalian Sterile 20-like kinase 1 (MST1) in it.	Curcumin	48-56	macrophage stimulating 1	Homo sapiens	154-158
33923651-0	2021	Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling.	Curcumin	0-8	C-C motif chemokine ligand 2	Homo sapiens	49-54
33923651-3	2021	Monocyte chemoattractant protein-1 (MCP-1) is a key inflammatory marker during the development of atherosclerosis, and curcumin blocks MCP-1 expression stimulated by various ligands.	Curcumin	119-127	C-C motif chemokine ligand 2	Homo sapiens	135-140
33923651-4	2021	Hence, we studied the action of curcumin on lysophosphatidic acid (LPA) mediated MCP-1 expression and explored the specific underlying mechanisms.	Curcumin	32-40	C-C motif chemokine ligand 2	Homo sapiens	81-86
33923651-7	2021	Curcumin blocks LPA mediated TGFBR1 transactivation and subsequent MCP-1 expression by blocking the ROCK signalling.	Curcumin	0-8	transforming growth factor beta receptor 1	Homo sapiens	29-35
33923651-7	2021	Curcumin blocks LPA mediated TGFBR1 transactivation and subsequent MCP-1 expression by blocking the ROCK signalling.	Curcumin	0-8	C-C motif chemokine ligand 2	Homo sapiens	67-72
33861386-15	2022	mRNA expression levels of IL-6 and IL-1beta were lower in curcumin-treated samples as compared to PHA alone, both amongst pSS and control groups (p = 0.0009 and p = 0.04, respectively).	Curcumin	58-66	interleukin 1 alpha	Homo sapiens	35-43
33861386-18	2022	Curcumin also suppressed PHA-induced mRNA expression levels of IL-6 and IL-1beta in MSG tissue of patients with pSS and controls.	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	72-80
33861392-7	2021	Following cryopreservation, GPX4 mRNA expression was significantly upregulated in thawed semen supplemented with 20 muM curcumin compared to the control.	Curcumin	120-128	glutathione peroxidase 4	Homo sapiens	28-32
33975064-0	2021	Curcumin improves insulin sensitivity and increases energy expenditure in high-fat-diet-induced obese mice associated with activation of FNDC5/irisin.	Curcumin	0-8	fibronectin type III domain containing 5	Mus musculus	137-142
33975064-2	2021	The aim of this study was to evaluate whether the beneficial metabolic effects of curcumin are associated with the regulation of energy metabolism and activation of fibronectin type 3 domain-containing protein 5 (FNDC5)/irisin.	Curcumin	82-90	fibronectin type III domain containing 5	Mus musculus	213-218
33824458-0	2022	C0818, a novel curcumin derivative, induces ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 function.	Curcumin	15-23	heat shock protein 90 alpha family class A member 1	Homo sapiens	138-143
33824458-4	2022	Compared to curcumin, a novel derivative of curcumin, 3,5-(E)-Bis(3-methoxy-4-hydroxybenzal)-4-piperidinone hydrochloride (C0818) that is more potent in Hsp90 inhibition and antitumor activity.	Curcumin	44-52	heat shock protein 90 alpha family class A member 1	Homo sapiens	153-158
33517224-0	2021	Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	107-112
24076327-6	2013	Our in vivo data demonstrated that curcumin ameliorated fibrotic injury, and downregulated CBR1 but upregulated CBR2 at both mRNA and protein levels in rat fibrotic liver caused by carbon tetrachloride.	Curcumin	35-43	carbonyl reductase 1	Rattus norvegicus	91-95
24076327-7	2013	The subsequent in vitro investigations showed that curcumin reduced the mRNA and protein abundance of CBR1 in cultured HSCs and decreased the expression of three critical ECM proteins.	Curcumin	51-59	carbonyl reductase 1	Rattus norvegicus	102-106
24076327-8	2013	Further analyses revealed that CBR1 agonist abrogated the curcumin inhibition of ECM expression, but CBR1 antagonist mimicked and reinforced the curcumin effects.	Curcumin	58-66	carbonyl reductase 1	Rattus norvegicus	31-35
24076327-8	2013	Further analyses revealed that CBR1 agonist abrogated the curcumin inhibition of ECM expression, but CBR1 antagonist mimicked and reinforced the curcumin effects.	Curcumin	145-153	carbonyl reductase 1	Rattus norvegicus	101-105
24076327-9	2013	Autodock simulations predicted that curcumin could bind to CBR1 with two hydrogen bonds.	Curcumin	36-44	carbonyl reductase 1	Rattus norvegicus	59-63
24076327-10	2013	Collectively, our current studies revealed that curcumin reduction of liver fibrosis was associated with modulation of CBRs system and that antagonism of CBR1 contributed to curcumin inhibition of ECM expression in HSCs.	Curcumin	174-182	carbonyl reductase 1	Rattus norvegicus	154-158
33517224-4	2021	In this study, we explored the curcumin analogue AI-44 alleviated the gouty arthritis in mice via suppressing MSU engaging NLRP3 inflammasome activation.	Curcumin	31-39	NLR family, pyrin domain containing 3	Mus musculus	123-128
24236784-7	2013	Curcumin reversed doxorubicin-induced morphological changes, inhibited doxorubicin-induced downregulation of E-cadherin expressions, and inhibited doxorubicin-induced upregulation of vimentin expression.	Curcumin	0-8	vimentin	Homo sapiens	183-191
33732362-9	2021	In addition, the results demonstrated that curcumin inhibited the TLR4/NF-kappaB signaling pathway and the expression of inflammatory factors, including IL-6, IL-1beta, prostaglandin E2 and cyclooxygenase-2, in mouse xenograft tumors.	Curcumin	43-51	interleukin 1 alpha	Mus musculus	159-167
23998949-0	2013	Targeting EP4 by curcumin through cross talks of AMP-dependent kinase alpha and p38 mitogen-activated protein kinase signaling: the role of PGC-1alpha and Sp1.	Curcumin	17-25	prostaglandin E receptor 4	Homo sapiens	10-13
23998949-4	2013	In this study, we showed that curcumin inhibits head and neck cancer cell growth through reduction of PGE2 receptor EP4 gene expression.	Curcumin	30-38	prostaglandin E receptor 4	Homo sapiens	116-119
23998949-5	2013	Blockade of AMP-dependent kinase (AMPK), and p38 MAPK by either chemical inhibitors or siRNAs antagonized the inhibitory effect of curcumin on EP4 expression, which was reversed by metformin, an activator of AMPK.	Curcumin	131-139	prostaglandin E receptor 4	Homo sapiens	143-146
33656766-11	2021	Meanwhile, the protein level of ACSL4 was higher and the levels of SLC7A11 and GPX4 were lower in curcumin group than that in control group.	Curcumin	98-106	solute carrier family 7 member 11	Homo sapiens	67-74
23998949-7	2013	Silencing of PGC-1alpha reversed the effect of curcumin on EP4 protein.	Curcumin	47-55	prostaglandin E receptor 4	Homo sapiens	59-62
23998949-8	2013	Overexpression of EP4 overcame the effect of curcumin on head and neck cancer cell growth.	Curcumin	45-53	prostaglandin E receptor 4	Homo sapiens	18-21
23998949-10	2013	Overexpression of Sp1 resisted the inhibitory effect of curcumin on EP4 promoter activity and protein expression.	Curcumin	56-64	prostaglandin E receptor 4	Homo sapiens	68-71
33656766-11	2021	Meanwhile, the protein level of ACSL4 was higher and the levels of SLC7A11 and GPX4 were lower in curcumin group than that in control group.	Curcumin	98-106	glutathione peroxidase 4	Homo sapiens	79-83
33540171-0	2021	Keto form of curcumin derivatives strongly binds to Abeta oligomers but not fibrils.	Curcumin	13-21	amyloid beta (A4) precursor protein	Mus musculus	52-57
23998949-12	2013	In conclusion, this study shows that curcumin inhibits EP4 gene expression dependent of AMPKalpha and p38 MAPK activation, this leads to reduction of Sp1 protein and binding to specific area in the EP4 gene promoter.	Curcumin	37-45	prostaglandin E receptor 4	Homo sapiens	55-58
23998949-12	2013	In conclusion, this study shows that curcumin inhibits EP4 gene expression dependent of AMPKalpha and p38 MAPK activation, this leads to reduction of Sp1 protein and binding to specific area in the EP4 gene promoter.	Curcumin	37-45	prostaglandin E receptor 4	Homo sapiens	198-201
24064724-3	2013	We identified that curcumin interrupts wnt signaling by decreasing beta-catenin activity, which in turn suppresses the expression of beta-catenin target genes (c-myc, VEGF and cyclin D1).	Curcumin	19-27	catenin beta 1	Homo sapiens	67-79
24064724-3	2013	We identified that curcumin interrupts wnt signaling by decreasing beta-catenin activity, which in turn suppresses the expression of beta-catenin target genes (c-myc, VEGF and cyclin D1).	Curcumin	19-27	catenin beta 1	Homo sapiens	133-145
24064724-3	2013	We identified that curcumin interrupts wnt signaling by decreasing beta-catenin activity, which in turn suppresses the expression of beta-catenin target genes (c-myc, VEGF and cyclin D1).	Curcumin	19-27	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	160-165
24064724-4	2013	Our results from molecular simulation of curcumin binding to Dvl2 protein and from binding free energy calculations suggest that curcumin may prevent axin recruitment to cellular membrane in order to maintain the functional beta-catenin destruction complex in normal cells.	Curcumin	129-137	catenin beta 1	Homo sapiens	224-236
23794119-13	2013	Curcumin effect was mediated through activation of TNFR, CASP 8, CASP3, BID, BAX, and down-regulation of NFkappaB, NDRG 1, and BCL2L10 genes.	Curcumin	0-8	TNF receptor superfamily member 1A	Homo sapiens	51-55
33540171-2	2021	During binding to Abeta fibrils, curcumin, which can exist in an equilibrium state between its keto and enol tautomers, exists predominantly in the enol form, and binding activity of the keto form to Abeta fibrils is much weaker.	Curcumin	33-41	amyloid beta (A4) precursor protein	Mus musculus	18-23
33540171-2	2021	During binding to Abeta fibrils, curcumin, which can exist in an equilibrium state between its keto and enol tautomers, exists predominantly in the enol form, and binding activity of the keto form to Abeta fibrils is much weaker.	Curcumin	33-41	amyloid beta (A4) precursor protein	Mus musculus	200-205
33540171-3	2021	Here we described the strong binding activity the keto form of curcumin derivative Shiga-Y51 shows for Abeta oligomers and its scant affinity for Abeta fibrils.	Curcumin	63-71	amyloid beta (A4) precursor protein	Mus musculus	103-108
33540171-3	2021	Here we described the strong binding activity the keto form of curcumin derivative Shiga-Y51 shows for Abeta oligomers and its scant affinity for Abeta fibrils.	Curcumin	63-71	amyloid beta (A4) precursor protein	Mus musculus	146-151
33540171-5	2021	The keto form of curcumin derivatives like Shiga-Y51 could be promising seed compounds to develop imaging probes and therapeutic agents targeting Abeta oligomers in the brain.	Curcumin	17-25	amyloid beta (A4) precursor protein	Mus musculus	146-151
34014157-0	2021	Curcumin alleviates inflammation in Takayasu"s arteritis by blocking CCL2 overexpression in adventitial fibroblasts.	Curcumin	0-8	C-C motif chemokine ligand 2	Homo sapiens	69-73
34014157-8	2021	RT-qPCR, ELISA and western blot were used to determine the regulatory effect of curcumin on CCL2 expression in aortic adventitia fibroblasts (AAFs) and its mechanism.	Curcumin	80-88	C-C motif chemokine ligand 2	Homo sapiens	92-96
24116384-1	2013	In this article, we first designed and synthesized curcumin-based near-infrared (NIR) fluorescence imaging probes for detecting both soluble and insoluble amyloid beta (Abeta) species and then an inhibitor that could attenuate cross-linking of Abeta induced by copper.	Curcumin	51-59	amyloid beta (A4) precursor protein	Mus musculus	169-174
24116384-1	2013	In this article, we first designed and synthesized curcumin-based near-infrared (NIR) fluorescence imaging probes for detecting both soluble and insoluble amyloid beta (Abeta) species and then an inhibitor that could attenuate cross-linking of Abeta induced by copper.	Curcumin	51-59	amyloid beta (A4) precursor protein	Mus musculus	244-249
34014157-9	2021	RESULTS: Curcumin treatment significantly lowered Kerr score and the levels of serum CCL2 in TAK patients.	Curcumin	9-17	C-C motif chemokine ligand 2	Homo sapiens	85-89
24116384-7	2013	In CRANAD-17, a curcumin scaffold was used as an anchoring moiety to usher the designed compound to the vicinity of H13 and H14 of Abeta, and imidazole rings were incorporated to compete with H13/H14 for copper binding.	Curcumin	16-24	amyloid beta (A4) precursor protein	Mus musculus	131-136
24063989-0	2013	Low doses of curcumin protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK.	Curcumin	13-21	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	107-113
34014157-12	2021	After curcumin treatment, the changes in CCL2 were positively associated with the changes in IL-6.	Curcumin	6-14	C-C motif chemokine ligand 2	Homo sapiens	41-45
34014157-15	2021	Nevertheless, curcumin could reverse the HSP65-induced CCL2 upregulation through restraining JAK2/AKT/STAT3 pathway.	Curcumin	14-22	C-C motif chemokine ligand 2	Homo sapiens	55-59
24134840-2	2013	We observed that curcumin activated MST1-dependent apoptosis in cultured melanoma cells.	Curcumin	17-25	macrophage stimulating 1	Homo sapiens	36-40
34014157-17	2021	CONCLUSIONS: Curcumin alleviated inflammation in TAK by downregulating CCL2 overexpression in AAFs through inhibiting the JAK2/AKT/STAT3 signalling pathway.	Curcumin	13-21	C-C motif chemokine ligand 2	Homo sapiens	71-75
24224124-6	2013	Most importantly, we found that the treatment of pancreatic cancer cells with isoflavone mixture (G2535), formulated 3,3"-diindolylmethane (BR-DIM), or synthetic curcumin analogue (CDF) could down-regulate the expression of miR-221 and consequently up-regulate the expression of PTEN, p27(kip1), p57(kip2), and PUMA, leading to the inhibition of cell proliferation and migration of MiaPaCa-2 and Panc-1 cells.	Curcumin	162-170	microRNA 221	Homo sapiens	224-231
33495815-8	2021	Additionally, to the best of our knowledge, the present study was the first to demonstrate the synergistic effect of Cur and GB on the inhibition of cystogenesis in Pkd1 knockout mice.	Curcumin	117-120	polycystin 1, transient receptor potential channel interacting	Mus musculus	165-169
23881281-2	2013	The results indicated that curcumin inhibited the gastrointestinal carcinoma cell growth in a dose-dependent manner and cytotoxicity was more towards the gastric carcinoma cell AGS and colon carcinoma cell HT-29 compared to normal gastric cell GES-1, and increased externalization of phosphatidylserine residue was observed by Annexin V/PI staining in the two cell lines.	Curcumin	27-35	annexin A5	Homo sapiens	327-336
23881281-5	2013	Overexpression of bax, total JNK, phospho-FADD and total FADD were also observed in curcumin-treated HT-29 cells.	Curcumin	84-92	Fas associated via death domain	Homo sapiens	42-46
23881281-5	2013	Overexpression of bax, total JNK, phospho-FADD and total FADD were also observed in curcumin-treated HT-29 cells.	Curcumin	84-92	Fas associated via death domain	Homo sapiens	57-61
33670518-9	2021	It seems that anti-tumor compounds such as baicalein, propofol, and curcumin can induce PTEN upregulation by affecting miRNAs in suppressing breast and lung cancer progression.	Curcumin	68-76	phosphatase and tensin homolog	Homo sapiens	88-92
23846485-5	2013	Immunoblotting, RNA interference, and use of chemical inhibitors of TRAIL-activate signaling revealed differential effects of curcumin on the expression of Mcl-1 and activities of ERK and Akt.	Curcumin	126-134	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	156-161
23816368-0	2013	The curry spice curcumin attenuates beta-amyloid-induced toxicity through beta-catenin and PI3K signaling in rat organotypic hippocampal slice culture.	Curcumin	16-24	catenin beta 1	Rattus norvegicus	74-86
23816368-3	2013	The present study was undertaken to investigate the mechanisms involved in neuroprotective effects of curcumin, particularly involving Wnt/beta-catenin and PI3K pathways.	Curcumin	102-110	catenin beta 1	Rattus norvegicus	139-151
23816368-8	2013	The phosphorylation of beta-catenin was avoided and the levels of free beta-catenin were increased by curcumin to promote cell survival upon treatment with Abeta.	Curcumin	102-110	catenin beta 1	Rattus norvegicus	71-83
23816368-11	2013	DISCUSSION: These results reinforce the neuroprotective effects of curcumin on Abeta toxicity and add some evidence that its mechanism may involve beta-catenin and PI3K signaling pathway in organotypic hippocampal slice culture.	Curcumin	67-75	catenin beta 1	Rattus norvegicus	147-159
33596716-4	2022	This review discusses reports of modulation of the Wnt/beta-Catenin signaling pathway by dietary polyphenols (resveratrol, avenanthramides, epigallocatechinin, curcumin, quercetin, silibinin, genistein and mangiferin) specifically focusing on CRC, and proposes a model as to how this modulation occurs.	Curcumin	160-168	catenin beta 1	Homo sapiens	55-67
23665314-5	2013	Furthermore, curcumin treatment prevented significantly elevation of serum IgE, IL-4, NO in nasal lavage and eosinophil peroxidase in nasal homogenate.	Curcumin	13-21	interleukin-4	Cavia porcellus	80-84
23754571-6	2013	Finally curcumin modulates miRNAs (miR-15a, miR-16, miR-21, miR-22, miR-26, miR-101, miR-146, miR-200, miR-203, and let-7) and their multiple target genes.	Curcumin	8-16	microRNA 21	Homo sapiens	52-58
22653297-8	2013	Lifespan extension of curcumin in Drosophila was associated with the up-regulation of Mn-SOD and CuZn-SOD genes, and the down-regulation of dInR, ATTD, Def, CecB, and DptB genes.	Curcumin	22-30	Attacin-D	Drosophila melanogaster	146-150
33566305-0	2021	Curcumin suppresses tumor growth of gemcitabine-resistant non-small cell lung cancer by regulating lncRNA-MEG3 and PTEN signaling.	Curcumin	0-8	phosphatase and tensin homolog	Homo sapiens	115-119
33566305-6	2021	Curcumin upregulated the expression of lncRNA-MEG3 and PTEN, and MEG3 overexpression could increase the level of PTEN expression, while MEG3 knockdown decreased the level of PTEN expression in gemcitabine-resistant non-small cell lung cancer cells.	Curcumin	0-8	phosphatase and tensin homolog	Homo sapiens	55-59
33566305-6	2021	Curcumin upregulated the expression of lncRNA-MEG3 and PTEN, and MEG3 overexpression could increase the level of PTEN expression, while MEG3 knockdown decreased the level of PTEN expression in gemcitabine-resistant non-small cell lung cancer cells.	Curcumin	0-8	maternally expressed 3	Homo sapiens	46-50
33551001-13	2021	Conclusion: The present results suggest that curcumin increases cAMP levels via inhibition of PDE4A phosphorylation, which induces mitochondrial biogenesis through a cAMP/PKA/AMPK signalling pathway.	Curcumin	45-53	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	171-174
33538682-9	2021	In addition, pretreatment with curcumin down-regulated pro-apoptotic (Bax), and up-regulated antiapoptotic (Bcl2) mediators.	Curcumin	31-39	BCL2 associated X, apoptosis regulator	Rattus norvegicus	70-73
23898073-5	2013	Curcumin feeding reduced plasma concentrations of osteocalcin and increased tartrate-resistant acid phosphate 5b in mice regardless of the presence of LLC, indicating that curcumin disrupts the balance of bone remodeling.	Curcumin	0-8	bone gamma-carboxyglutamate protein 2	Mus musculus	50-61
23430957-0	2013	Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases.	Curcumin	5-13	suppressor of cytokine signaling 1	Homo sapiens	42-47
23430957-3	2013	However, whether curcumin can regulate the expression of SOCS1 and SOCS3 is still unknown.	Curcumin	17-25	suppressor of cytokine signaling 1	Homo sapiens	57-62
33278547-7	2021	By caspase and Annexin V assays, we could demonstrate Curcumin at 3 muM to 8 muM concentration could initiate p53 mediated apoptosis in BxPC-3 cell lines.	Curcumin	54-62	annexin A5	Homo sapiens	15-24
23430957-4	2013	Here, we found that curcumin elevated the expression of SOCS1 and SOCS3 via triggering acetylation of histone in the regions of SOCS1 and SOCS3 promoter in K562 and HEL cells.	Curcumin	20-28	suppressor of cytokine signaling 1	Homo sapiens	56-61
23430957-4	2013	Here, we found that curcumin elevated the expression of SOCS1 and SOCS3 via triggering acetylation of histone in the regions of SOCS1 and SOCS3 promoter in K562 and HEL cells.	Curcumin	20-28	suppressor of cytokine signaling 1	Homo sapiens	128-133
33376508-8	2021	Curcumin pre-treatment decreased blood urea nitrogen and serum creatinine, urinary kidney injury molecule-1, and neutrophil gelatinase-associated lipocalin levels compared with the dry-heat control group.	Curcumin	0-8	hepatitis A virus cellular receptor 1	Rattus norvegicus	83-107
23430957-8	2013	Thus, HDAC8 plays an important role in the modulation of SOCS1 and SOCS3 by curcumin.	Curcumin	76-84	histone deacetylase 8	Homo sapiens	6-11
23430957-8	2013	Thus, HDAC8 plays an important role in the modulation of SOCS1 and SOCS3 by curcumin.	Curcumin	76-84	suppressor of cytokine signaling 1	Homo sapiens	57-62
23430957-10	2013	Furthermore, curcumin increased the transcript levels of SOCS1 and SOCS3 and significantly inhibited the clonogenic activity of hematopoietic progenitors from patients with MPNs.	Curcumin	13-21	suppressor of cytokine signaling 1	Homo sapiens	57-62
33376508-9	2021	Curcumin was also revealed to downregulate c-Jun N-terminal kinases (JNK), cytochrome c, caspase-3 and caspase-9 expression upon treatment with 100 and 200 mg/kg curcumin, which may result in inhibition of the mitochondrial apoptotic pathway in renal cells.	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	43-67
23430957-11	2013	Finally, curcumin markedly inhibited HDAC activities and decreased HDAC8 levels in primary MPN cells.	Curcumin	9-17	histone deacetylase 8	Homo sapiens	67-72
33376508-9	2021	Curcumin was also revealed to downregulate c-Jun N-terminal kinases (JNK), cytochrome c, caspase-3 and caspase-9 expression upon treatment with 100 and 200 mg/kg curcumin, which may result in inhibition of the mitochondrial apoptotic pathway in renal cells.	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	69-72
23430957-12	2013	Taken together, our data uncover a regulatory mechanism of SOCS1 and SOCS3 through inhibition of HDAC activity (especially HDAC8) by curcumin.	Curcumin	133-141	suppressor of cytokine signaling 1	Homo sapiens	59-64
23430957-12	2013	Taken together, our data uncover a regulatory mechanism of SOCS1 and SOCS3 through inhibition of HDAC activity (especially HDAC8) by curcumin.	Curcumin	133-141	histone deacetylase 8	Homo sapiens	123-128
33376508-9	2021	Curcumin was also revealed to downregulate c-Jun N-terminal kinases (JNK), cytochrome c, caspase-3 and caspase-9 expression upon treatment with 100 and 200 mg/kg curcumin, which may result in inhibition of the mitochondrial apoptotic pathway in renal cells.	Curcumin	162-170	mitogen-activated protein kinase 8	Rattus norvegicus	43-67
23726918-4	2013	Curcumin enhanced Erk1/2 predominantly in Ras-activated cells, but inhibited Akt and its downstream molecules (mTOR and S6K1) regardless of these oncogene activations.	Curcumin	0-8	ribosomal protein S6 kinase B1	Homo sapiens	120-124
33645034-0	2021	[Curcumin mediates IL-6/STAT3 signaling pathway to repair intestinal mucosal injury induced by 5-FU chemotherapy for colon cancer].	Curcumin	1-9	signal transducer and activator of transcription 3	Rattus norvegicus	24-29
23825622-8	2013	We inferred that curcumin was capable of impacting the IL-23/IL-17A axis by inhibiting IL-1beta/IL-6 and then indirectly down-regulating IL-17A/IL-22 production.	Curcumin	17-25	interleukin 22	Mus musculus	144-149
33645034-1	2021	This study aims to investigate the potential mechanism of curcumin in mediating interleukin-6(IL-6)/signal transducer and activator of transcription 3(STAT3) signaling pathway to repair intestinal mucosal injury induced by 5-fluorouracil(5-FU) chemotherapy for colon cancer.	Curcumin	58-66	signal transducer and activator of transcription 3	Rattus norvegicus	100-150
23532091-10	2013	Curcumin increased extracellular signal-regulated kinase 1/2 activity in both SKN and SK-UT-1 cells, whereas PD98059, an MEK1 inhibitor, inhibited both the extracellular signal-regulated kinase 1/2 pathway and curcumin-induced autophagy.	Curcumin	210-218	mitogen-activated protein kinase kinase 1	Homo sapiens	121-125
33645034-1	2021	This study aims to investigate the potential mechanism of curcumin in mediating interleukin-6(IL-6)/signal transducer and activator of transcription 3(STAT3) signaling pathway to repair intestinal mucosal injury induced by 5-fluorouracil(5-FU) chemotherapy for colon cancer.	Curcumin	58-66	signal transducer and activator of transcription 3	Rattus norvegicus	151-156
23671702-0	2013	Curcumin nanoparticles ameliorate ICAM-1 expression in TNF-alpha-treated lung epithelial cells through p47 (phox) and MAPKs/AP-1 pathways.	Curcumin	0-8	pleckstrin	Homo sapiens	103-106
33645034-12	2021	Meanwhile, curcumin could increase the positive expression of occludin, claudin and ZO-1(P<0.05 or P<0.01), repair intestinal barrier function, downregulate the protein expression of IL-6, p-STAT3, vimentin and N-cadherin in jejunum tissues(P<0.05 or P<0.01), and upregulate the protein expression of E-cadherin(P<0.05).	Curcumin	11-19	tight junction protein 1	Rattus norvegicus	84-88
33645034-12	2021	Meanwhile, curcumin could increase the positive expression of occludin, claudin and ZO-1(P<0.05 or P<0.01), repair intestinal barrier function, downregulate the protein expression of IL-6, p-STAT3, vimentin and N-cadherin in jejunum tissues(P<0.05 or P<0.01), and upregulate the protein expression of E-cadherin(P<0.05).	Curcumin	11-19	signal transducer and activator of transcription 3	Rattus norvegicus	191-196
33645034-12	2021	Meanwhile, curcumin could increase the positive expression of occludin, claudin and ZO-1(P<0.05 or P<0.01), repair intestinal barrier function, downregulate the protein expression of IL-6, p-STAT3, vimentin and N-cadherin in jejunum tissues(P<0.05 or P<0.01), and upregulate the protein expression of E-cadherin(P<0.05).	Curcumin	11-19	cadherin 2	Rattus norvegicus	211-221
33645034-12	2021	Meanwhile, curcumin could increase the positive expression of occludin, claudin and ZO-1(P<0.05 or P<0.01), repair intestinal barrier function, downregulate the protein expression of IL-6, p-STAT3, vimentin and N-cadherin in jejunum tissues(P<0.05 or P<0.01), and upregulate the protein expression of E-cadherin(P<0.05).	Curcumin	11-19	cadherin 1	Rattus norvegicus	301-311
33645034-13	2021	Therefore, curcumin could repair the intestinal mucosal injury induced by 5-FU chemotherapy for colon cancer, and the mechanism may be related to the inhibition of IL-6/STAT3 signal and the inhibition of epithelial-mesenchymal transition(EMT) process.	Curcumin	11-19	signal transducer and activator of transcription 3	Rattus norvegicus	169-174
33501725-0	2021	Curcumin regulates EZH2/Wnt/beta-Catenin pathway in the mandible and femur of ovariectomized osteoporosis rats.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	28-40
33501725-10	2021	Curcumin inhibited EZH2 mRNA level and induced that of beta-Catenin and Runx2 in the mandible and femur.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	55-67
33501725-11	2021	Collectively, curcumin exerts protective effects against OP, possibly by regulating the EZH2/Wnt/beta-Catenin pathway.	Curcumin	14-22	catenin beta 1	Rattus norvegicus	97-109
33346657-4	2021	Considering these aspects, we employed curcumin as a cross-linking agent to facilitate the modular assembly of drug and monodisperse SPIONs (Cur/ALN-beta-CD-SPIONs).	Curcumin	39-47	adrenocortical dysplasia	Mus musculus	149-156
23524096-0	2013	2a, a novel curcumin analog, sensitizes cisplatin-resistant A549 cells to cisplatin by inhibiting thioredoxin reductase concomitant oxidative stress damage.	Curcumin	12-20	peroxiredoxin 5	Homo sapiens	98-119
23524096-1	2013	(1E,4Z,6E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(5-methylfuran-2-yl)hepta-1,4,6-trien-3-one (2a), a novel curcumin analog, was previously synthesized in our laboratory as a potential thioredoxin reductase (TrxR) inhibitor with excellent growth inhibitory effects on several TrxR over-expressed cancer cells.	Curcumin	111-119	peroxiredoxin 5	Homo sapiens	188-209
23524096-1	2013	(1E,4Z,6E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(5-methylfuran-2-yl)hepta-1,4,6-trien-3-one (2a), a novel curcumin analog, was previously synthesized in our laboratory as a potential thioredoxin reductase (TrxR) inhibitor with excellent growth inhibitory effects on several TrxR over-expressed cancer cells.	Curcumin	111-119	peroxiredoxin 5	Homo sapiens	211-215
23524096-1	2013	(1E,4Z,6E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(5-methylfuran-2-yl)hepta-1,4,6-trien-3-one (2a), a novel curcumin analog, was previously synthesized in our laboratory as a potential thioredoxin reductase (TrxR) inhibitor with excellent growth inhibitory effects on several TrxR over-expressed cancer cells.	Curcumin	111-119	peroxiredoxin 5	Homo sapiens	279-283
23645731-5	2013	Upon curcumin treatment, AKT activation was substantially suppressed, with subsequent reduction of activities of mammalian target of rapamycin (mTOR) and its downstream molecules S6 kinase-1 (S6K1) and elF4E-binding protein-1 (4E-BP1), but constitutive activity of extracellular signal-regulated kinase (ERK1/2) was clearly enhanced.	Curcumin	5-13	ribosomal protein S6 kinase B1	Homo sapiens	179-190
23645731-5	2013	Upon curcumin treatment, AKT activation was substantially suppressed, with subsequent reduction of activities of mammalian target of rapamycin (mTOR) and its downstream molecules S6 kinase-1 (S6K1) and elF4E-binding protein-1 (4E-BP1), but constitutive activity of extracellular signal-regulated kinase (ERK1/2) was clearly enhanced.	Curcumin	5-13	ribosomal protein S6 kinase B1	Homo sapiens	192-196
23645731-5	2013	Upon curcumin treatment, AKT activation was substantially suppressed, with subsequent reduction of activities of mammalian target of rapamycin (mTOR) and its downstream molecules S6 kinase-1 (S6K1) and elF4E-binding protein-1 (4E-BP1), but constitutive activity of extracellular signal-regulated kinase (ERK1/2) was clearly enhanced.	Curcumin	5-13	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	202-233
33536913-0	2020	Curcumin Nanoparticle Enhances the Anticancer Effect of Cisplatin by Inhibiting PI3K/AKT and JAK/STAT3 Pathway in Rat Ovarian Carcinoma Induced by DMBA.	Curcumin	0-8	signal transducer and activator of transcription 3	Rattus norvegicus	97-102
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	100-108	endoplasmic reticulum (ER) to nucleus signalling 2	Mus musculus	277-304
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	100-108	endoplasmic reticulum (ER) to nucleus signalling 2	Mus musculus	306-310
23299930-8	2013	EF24, a molecule having structural similarity to curcumin, could synergistically enhance the antitumor effects of sorafenib and overcome sorafenib resistance through inhibiting HIF-1alpha by sequestering it in cytoplasm and promoting degradation by way of up-regulating Von Hippel-Lindau tumor suppressor (VHL).	Curcumin	49-57	hypoxia inducible factor 1, alpha subunit	Mus musculus	177-187
24134840-3	2013	MST1 silencing by RNA interference (RNAi) suppressed curcumin-induced cell apoptosis, while MST1 over-expressing increased curcumin sensitivity.	Curcumin	53-61	macrophage stimulating 1	Homo sapiens	0-4
24134840-3	2013	MST1 silencing by RNA interference (RNAi) suppressed curcumin-induced cell apoptosis, while MST1 over-expressing increased curcumin sensitivity.	Curcumin	123-131	macrophage stimulating 1	Homo sapiens	92-96
33747866-5	2021	Results: Curcumin, PGV-0, and PGV-1 exhibited cytotoxic effect against HER2-overexpressing breast cancer cells.	Curcumin	9-17	erb-b2 receptor tyrosine kinase 2	Mus musculus	71-75
24134840-4	2013	Meanwhile, curcumin induced reactive oxygen species (ROS) production in melanoma cells, and the ROS scavenger, N-acetyl-cysteine (NAC), almost blocked MST1 activation to suggest that ROS might be required for MST1 activation by curcumin.	Curcumin	11-19	macrophage stimulating 1	Homo sapiens	151-155
24134840-4	2013	Meanwhile, curcumin induced reactive oxygen species (ROS) production in melanoma cells, and the ROS scavenger, N-acetyl-cysteine (NAC), almost blocked MST1 activation to suggest that ROS might be required for MST1 activation by curcumin.	Curcumin	11-19	macrophage stimulating 1	Homo sapiens	209-213
24134840-5	2013	c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation.	Curcumin	52-60	macrophage stimulating 1	Homo sapiens	78-82
24134840-5	2013	c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation.	Curcumin	139-147	macrophage stimulating 1	Homo sapiens	78-82
24134840-5	2013	c-Jun N-terminal protein kinase (JNK) activation by curcumin was dependent on MST1, since MST1 inhibition by RNAi or NAC largely inhibited curcumin-induced JNK activation.	Curcumin	139-147	macrophage stimulating 1	Homo sapiens	90-94
24134840-6	2013	Further, curcumin induced Foxo3 nuclear translocation and Bim-1 (Foxo3 target gene) expression in melanoma cells, such an effect by curcumin was inhibited by MST1 RNAi.	Curcumin	9-17	macrophage stimulating 1	Homo sapiens	158-162
24134840-6	2013	Further, curcumin induced Foxo3 nuclear translocation and Bim-1 (Foxo3 target gene) expression in melanoma cells, such an effect by curcumin was inhibited by MST1 RNAi.	Curcumin	132-140	macrophage stimulating 1	Homo sapiens	158-162
23658623-3	2013	Here, we showed curcumin-mediated regulation of CD2/CD3/CD28-initiated CD4(+) T cell activation in vitro.	Curcumin	16-24	CD2 molecule	Homo sapiens	48-51
23658623-5	2013	We found that curcumin suppresses CD2/CD3/CD28-initiated CD4(+) T cell activation by inhibiting cell proliferation, differentiation and cytokine production.	Curcumin	14-22	CD2 molecule	Homo sapiens	34-37
23658623-6	2013	On the other hand, curcumin attenuated the spontaneous decline of CD69 expression and indirectly increased expression of CCR7, L-selectin and Transforming growth factor-beta1 (TGF-beta1) at the late phase of CD2/CD3/CD28-initiated T cell activation.	Curcumin	19-27	selectin L	Homo sapiens	127-137
23658623-6	2013	On the other hand, curcumin attenuated the spontaneous decline of CD69 expression and indirectly increased expression of CCR7, L-selectin and Transforming growth factor-beta1 (TGF-beta1) at the late phase of CD2/CD3/CD28-initiated T cell activation.	Curcumin	19-27	CD2 molecule	Homo sapiens	208-211
24134840-7	2013	In conclusion, we suggested that MST1 activation by curcumin mediates JNK activation, Foxo3a nuclear translocation and apoptosis in melanoma cells.	Curcumin	52-60	macrophage stimulating 1	Homo sapiens	33-37
33747866-7	2021	Curcumin and PGV-0 inhibited membrane localization of HER2.	Curcumin	0-8	erb-b2 receptor tyrosine kinase 2	Mus musculus	54-58
24035895-3	2013	In this context, our present study examined three polyphenol compounds (curcumin, EGCG and resveratrol) for their possible activity against two endogenous proteins (BAG2 and LAMP1) that are shown to play a vital role in clearing tau tangles from neurons.	Curcumin	72-80	lysosomal-associated membrane protein 1	Rattus norvegicus	174-179
23658623-9	2013	CONCLUSIONS/SIGNIFICANCE: Curcumin not merely blocks, but regulates CD2/CD3/CD28-initiated CD4(+) T cell activation by augmenting CD69, CCR7, L-selectin and TGF-beta1 expression followed by regulatory T cell generation.	Curcumin	26-34	CD2 molecule	Homo sapiens	68-71
23658623-9	2013	CONCLUSIONS/SIGNIFICANCE: Curcumin not merely blocks, but regulates CD2/CD3/CD28-initiated CD4(+) T cell activation by augmenting CD69, CCR7, L-selectin and TGF-beta1 expression followed by regulatory T cell generation.	Curcumin	26-34	selectin L	Homo sapiens	142-152
33747866-8	2021	In contrast, PGV-1 neither inhibited localization nor decreased the expression of HER2, nonetheless showed the most potent inhibition against nuclear localization of p65 indicating the different mechanisms of curcumin, PGV-0, and PGV-1.	Curcumin	209-217	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	166-169
24142602-9	2013	Also, curcumin decreased hepatic lipogenesis such as SREBP-1, and FAS.	Curcumin	6-14	sterol regulatory element binding transcription factor 1	Homo sapiens	53-60
33202358-13	2021	CONCLUSION: Curcumin promotes the osteogenic differentiation of hPDLSCs, which may work through the EGR1.	Curcumin	12-20	early growth response 1	Homo sapiens	100-104
24142602-10	2013	Besides, we also found out the antioxidative effect of curcumin by increasing the expression of PPARalpha.	Curcumin	55-63	peroxisome proliferator activated receptor alpha	Homo sapiens	96-105
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	toll like receptor 4	Homo sapiens	231-236
24142602-12	2013	CONCLUSIONS: These results indicated that curcumin has the same ability to activate AMPK and then reduce SREBP-1, and FAS expression, finally leading to inhibit hepatic lipogenesis and hepatic antioxidative ability.	Curcumin	42-50	sterol regulatory element binding transcription factor 1	Homo sapiens	105-112
23336318-6	2013	RESULTS: We demonstrated that treatment of rats with curcumin significantly decreased elevated levels of cTn I and MDA (p &lt; 0.05) in plasma, and increase the levels of SOD (p &lt; 0.05) after CLP.	Curcumin	53-61	troponin I3, cardiac type	Rattus norvegicus	105-118
32530070-5	2021	We previously used curcumin, a diet-derived mTOR inhibitor, which possesses both anti-inflammatory and anti-proliferative properties, to improve learning and memory deficits in Tsc2+/- mice.	Curcumin	19-27	mechanistic target of rapamycin kinase	Mus musculus	44-48
23415873-6	2013	The treatment of T cells with curcumin induced the unfolded protein response (UPR) signaling pathway, initiated by the phosphorylation of PERK and IRE1.	Curcumin	30-38	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	138-142
23415873-7	2013	Furthermore, curcumin increased the expression of the ER stress associated transcriptional factors XBP-1, cleaved p50ATF6alpha and C/EBP homologous protein (CHOP) in human CD4+ and Jurkat T cells.	Curcumin	13-21	X-box binding protein 1	Homo sapiens	99-104
23325107-0	2013	Curcumin ameliorates the neurodegenerative pathology in A53T alpha-synuclein cell model of Parkinson"s disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.	Curcumin	0-8	ribosomal protein S6 kinase B1	Homo sapiens	146-152
23325107-5	2013	We further found that curcumin, a natural compound derived from the curry spice turmeric and with low toxicity in normal cells, could efficiently reduce the accumulation of A53T alpha-synuclein through downregulation of the mTOR/p70S6K signaling and recovery of macroautophagy which was suppressed.	Curcumin	22-30	synuclein alpha	Homo sapiens	178-193
23325107-5	2013	We further found that curcumin, a natural compound derived from the curry spice turmeric and with low toxicity in normal cells, could efficiently reduce the accumulation of A53T alpha-synuclein through downregulation of the mTOR/p70S6K signaling and recovery of macroautophagy which was suppressed.	Curcumin	22-30	ribosomal protein S6 kinase B1	Homo sapiens	229-235
23995676-3	2013	Curcumin seems to be one of these compounds, possessing key structural components effective toward fibrillation prevention, and its anti-amyloidogenic property has been reported for a number of model and disease-related proteins such as lysozyme and alpha-synuclein.	Curcumin	0-8	synuclein alpha	Homo sapiens	250-265
24114697-0	2013	In vivo study on the effects of curcumin on the expression profiles of anti-tumour genes (VEGF, CyclinD1 and CDK4) in liver of rats injected with DEN.	Curcumin	32-40	vascular endothelial growth factor A	Rattus norvegicus	90-94
24114697-2	2013	Results showed that blood levels of Gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase, glutathione S-transferase, and liver level of MD were significantly decreased after curcumin feeding.	Curcumin	201-209	gamma-glutamyltransferase 1	Rattus norvegicus	36-61
24114697-2	2013	Results showed that blood levels of Gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase, glutathione S-transferase, and liver level of MD were significantly decreased after curcumin feeding.	Curcumin	201-209	hematopoietic prostaglandin D synthase	Rattus norvegicus	117-142
24114697-4	2013	Moreover, RT-PCR and Western blot analysis results showed that curcumin treatment significantly decreased liver vascular endothelial growth factor (VEGF), CyclinD1 and CDK4 mRNA expression levels and CyclinD1 and CDK4 proteins levels in liver cancer rats.	Curcumin	63-71	vascular endothelial growth factor A	Rattus norvegicus	112-146
24114697-4	2013	Moreover, RT-PCR and Western blot analysis results showed that curcumin treatment significantly decreased liver vascular endothelial growth factor (VEGF), CyclinD1 and CDK4 mRNA expression levels and CyclinD1 and CDK4 proteins levels in liver cancer rats.	Curcumin	63-71	vascular endothelial growth factor A	Rattus norvegicus	148-152
24422402-13	2013	CONCLUSION: Curcumin can recover the decreased AKT and p-AKT cells in hippocampus CAl area of APP/PS1 double transgenic mice of the AD model, suggesting that curcumin may regulate AKT and its phosphorylation process, as well as PI3K/AKT insulin signal transduction pathway, and show the anti-AD effect.	Curcumin	12-20	presenilin 1	Mus musculus	98-101
24422402-13	2013	CONCLUSION: Curcumin can recover the decreased AKT and p-AKT cells in hippocampus CAl area of APP/PS1 double transgenic mice of the AD model, suggesting that curcumin may regulate AKT and its phosphorylation process, as well as PI3K/AKT insulin signal transduction pathway, and show the anti-AD effect.	Curcumin	158-166	presenilin 1	Mus musculus	98-101
23574662-9	2013	By contrast, curcumin suppressed the HFD-mediated increases in sterol regulatory element-binding protein-1, acetyl-CoA carboxylase 1, fatty acid synthase and cluster of differentiation 36 expression.	Curcumin	13-21	sterol regulatory element binding transcription factor 1	Mus musculus	63-132
22628241-5	2013	Moreover, treatment with 0-30 microg/mL curcumin decreased the mitochondrial membrane potential and activated the caspase-3 and caspase-9 in a dose- and time-dependent manner.	Curcumin	40-48	caspase 9	Homo sapiens	128-137
22628241-6	2013	Nuclear and annexin V/PI staining showed that curcumin induced the apoptosis of LoVo cells.	Curcumin	46-54	annexin A5	Homo sapiens	12-21
32530070-5	2021	We previously used curcumin, a diet-derived mTOR inhibitor, which possesses both anti-inflammatory and anti-proliferative properties, to improve learning and memory deficits in Tsc2+/- mice.	Curcumin	19-27	TSC complex subunit 2	Mus musculus	177-181
23624207-7	2013	We performed Real Time Quantitative RT-PCR to confirm the upregulation of FRbeta mRNA in curcumin treated cells.	Curcumin	89-97	folate receptor beta	Homo sapiens	74-80
23624207-9	2013	Our data show that the mechanism of curcumin action involves up-regulation of folate receptor beta mRNA and protein in KG-1 cells.	Curcumin	36-44	folate receptor beta	Homo sapiens	78-98
32530070-7	2021	In this study, we confirmed that the impaired recognition memory and increased anxiety-like behavior in Tsc2+/- mice can be reversed by curcumin treatment.	Curcumin	136-144	TSC complex subunit 2	Mus musculus	104-108
32530070-9	2021	Finally, the mTOR complex 1 hyperactivity was found in the cortex and hippocampus, coinciding with abnormal cortical myelination and increased glial fibrillary acidic protein expression in the hippocampal CA1 of Tsc2+/- mice, both of which can be rescued with curcumin treatment.	Curcumin	260-268	mechanistic target of rapamycin kinase	Mus musculus	13-17
32530070-9	2021	Finally, the mTOR complex 1 hyperactivity was found in the cortex and hippocampus, coinciding with abnormal cortical myelination and increased glial fibrillary acidic protein expression in the hippocampal CA1 of Tsc2+/- mice, both of which can be rescued with curcumin treatment.	Curcumin	260-268	TSC complex subunit 2	Mus musculus	212-216
32727335-3	2021	n-3 fatty acids and curcumin revealed neuro-modulatory and anti-inflammatory effects through several pathways, of which the suppression of IL-1beta gene expression is an important inflammatory pathway.	Curcumin	20-28	interleukin 1 alpha	Homo sapiens	139-147
23894315-7	2013	Difluorinated curcumin (CDF), a novel analog of the dietary ingredient curcumin, which has been shown to inhibit the growth of 5-Flurouracil + Oxaliplatin resistant colon cancer cells, downregulated miR-21 in chemo-resistant colon cancer HCT116 and HT-29 cells and restored PTEN levels with subsequent reduction in Akt phosphorylation.	Curcumin	14-22	LIF interleukin 6 family cytokine	Homo sapiens	24-27
23894315-7	2013	Difluorinated curcumin (CDF), a novel analog of the dietary ingredient curcumin, which has been shown to inhibit the growth of 5-Flurouracil + Oxaliplatin resistant colon cancer cells, downregulated miR-21 in chemo-resistant colon cancer HCT116 and HT-29 cells and restored PTEN levels with subsequent reduction in Akt phosphorylation.	Curcumin	14-22	microRNA 21	Homo sapiens	199-205
23894315-7	2013	Difluorinated curcumin (CDF), a novel analog of the dietary ingredient curcumin, which has been shown to inhibit the growth of 5-Flurouracil + Oxaliplatin resistant colon cancer cells, downregulated miR-21 in chemo-resistant colon cancer HCT116 and HT-29 cells and restored PTEN levels with subsequent reduction in Akt phosphorylation.	Curcumin	14-22	phosphatase and tensin homolog	Homo sapiens	274-278
33505130-12	2021	Rabbits treated with curcumin showed a significant reduction in the serum level of high sensitive C-reactive protein, ICAM1, VCAM, PCSK9 serum expression and aortic total antioxidant capacity.	Curcumin	21-29	ICAM-1	Oryctolagus cuniculus	118-123
23181951-7	2013	Curcumin decreased the proteinuria level and serum levels of IgG1, IgG2a and anti-dsDNA IgG antibodies in NZB/W F1 female mice.	Curcumin	0-8	immunoglobulin heavy variable V1-9	Mus musculus	67-72
33017608-9	2021	In conclusion, Curcumin prevents kidney damage in diabetic rats by activating Nrf2, inhibiting Nf-kappaB, suppressing NADPH oxidase, and downregulating/inhibiting PKCbetaII/p66Shc axis.	Curcumin	15-23	phospholipase C, beta 2	Rattus norvegicus	163-179
24555068-0	2013	Curcumin reduces prostaglandin E2, matrix metalloproteinase-3 and proteoglycan release in the secretome of interleukin 1beta-treated articular cartilage.	Curcumin	0-8	stromelysin-1	Equus caballus	31-61
24555068-2	2013	The aim of this study was to determine whether non-toxic concentrations of curcumin can reduce interleukin-1beta (IL-1beta)-stimulated inflammation and catabolism in an explant model of cartilage inflammation.	Curcumin	75-83	interleukin-1 beta	Equus caballus	114-122
33179087-0	2021	Curcumin attenuates lncRNA H19-induced epithelial-mesenchymal transition in&nbsp;tamoxifen-resistant breast cancer cells.	Curcumin	0-8	H19 imprinted maternally expressed transcript	Homo sapiens	27-30
24555068-11	2013	Curcumin (&gt;=3muM) significantly reduced IL-1beta-stimulated PG ( p&lt;0.05) and PGE 2 release ( p&lt;0.001) from explants, whilst curcumin (&gt;=12muM) significantly reduced MMP-3 release ( p&lt;0.01).	Curcumin	0-8	interleukin-1 beta	Equus caballus	43-51
24555068-11	2013	Curcumin (&gt;=3muM) significantly reduced IL-1beta-stimulated PG ( p&lt;0.05) and PGE 2 release ( p&lt;0.001) from explants, whilst curcumin (&gt;=12muM) significantly reduced MMP-3 release ( p&lt;0.01).	Curcumin	0-8	stromelysin-1	Equus caballus	177-182
23347386-10	2013	Curcumin treatment reduced mRNA expression of inflammatory proteins monocyte chemoattractant protein-1 and transforming growth factor-beta and matrix proteins, fibronectin, laminin and collagen.	Curcumin	0-8	fibronectin 1	Mus musculus	160-171
33179087-4	2021	The present study aimed to investigate the role of H19 in MCF-7/TAMR cell epithelial-mesenchymal transition (EMT), migration and invasiveness, and to assess the ability of curcumin to inhibit H19-mediated effects.	Curcumin	172-180	H19 imprinted maternally expressed transcript	Homo sapiens	192-195
33179087-9	2021	In addition, following treatment with curcumin for 48 h, H19 expression was decreased in a dose-dependent manner.	Curcumin	38-46	H19 imprinted maternally expressed transcript	Homo sapiens	57-60
33179087-10	2021	Moreover, curcumin treatment for 48 h significantly attenuated H19-induced alterations in N-cadherin and E-cadherin expression levels.	Curcumin	10-18	H19 imprinted maternally expressed transcript	Homo sapiens	63-66
23730903-6	2013	Annexin V apoptotic studies showed that the PCDT complexation improved curcumin induced apoptosis in human ovarian cancer cell lines A2780 and SKOV-3, human nonsmall cell lung carcinoma cell line H1299, and human prostate cancer line DU-145, while no significant effect was observed with paclitaxel/PCDT complexation.	Curcumin	71-79	annexin A5	Homo sapiens	0-9
33179087-11	2021	Curcumin also prevented H19-induced invasion and migration.	Curcumin	0-8	H19 imprinted maternally expressed transcript	Homo sapiens	24-27
33179087-12	2021	The present study indicated that H19 may serve as a promoting factor of EMT, invasion and migration in MCF-7/TAMR cells, suggesting that curcumin may prevent H19-associated metastasis.	Curcumin	137-145	H19 imprinted maternally expressed transcript	Homo sapiens	33-36
25337545-7	2013	Moreover, the expression of p53, which is an upstream regulator of the CDK4-cylinD1 complex, was inhibited by curcumin treatment.	Curcumin	110-118	transformation related protein 53, pseudogene	Mus musculus	28-31
33179087-12	2021	The present study indicated that H19 may serve as a promoting factor of EMT, invasion and migration in MCF-7/TAMR cells, suggesting that curcumin may prevent H19-associated metastasis.	Curcumin	137-145	H19 imprinted maternally expressed transcript	Homo sapiens	158-161
23614750-4	2013	In this study, we investigated the inhibitory effects of curcumin on matrix metalloproteinase (MMP)-1 and MMP-3 expression in human dermal fibroblast cells.	Curcumin	57-65	matrix metallopeptidase 1	Homo sapiens	69-101
33953873-5	2021	In this study, the effect of curcumin administration on the change of the expression of MBP, NOGO-A, and iNOS genes was evaluated using the RT-PCR (Reverse transcription-polymerase chain reaction) technique.	Curcumin	29-37	myelin basic protein	Cavia porcellus	88-91
23614750-5	2013	Western blot analysis revealed that curcumin inhibited ultraviolet (UV) B-induced MMP-1 and MMP-3 expression.	Curcumin	36-44	matrix metallopeptidase 1	Homo sapiens	82-87
33953873-5	2021	In this study, the effect of curcumin administration on the change of the expression of MBP, NOGO-A, and iNOS genes was evaluated using the RT-PCR (Reverse transcription-polymerase chain reaction) technique.	Curcumin	29-37	reticulon 4	Homo sapiens	93-99
22290509-6	2013	The decreased cell viability observed in SkBr3 cells when curcumin was combined with TSA led to a G0/G1 cell cycle arrest and increased p21 and p27, and decreased Cyclin D1 protein expression.	Curcumin	58-66	H3 histone pseudogene 16	Homo sapiens	136-139
33953873-6	2021	The obtained results indicated it could be concluded that curcumin was able to improve EAE by increasing the amount of MBP gene expression and reducing the intensity of NOGO-A expression.	Curcumin	58-66	myelin basic protein	Cavia porcellus	119-122
22290509-6	2013	The decreased cell viability observed in SkBr3 cells when curcumin was combined with TSA led to a G0/G1 cell cycle arrest and increased p21 and p27, and decreased Cyclin D1 protein expression.	Curcumin	58-66	interferon alpha inducible protein 27	Homo sapiens	144-147
33953873-6	2021	The obtained results indicated it could be concluded that curcumin was able to improve EAE by increasing the amount of MBP gene expression and reducing the intensity of NOGO-A expression.	Curcumin	58-66	reticulon 4	Homo sapiens	169-175
33294119-0	2020	Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells.	Curcumin	57-65	heme oxygenase 1	Homo sapiens	74-78
23944055-1	2013	OBJECTIVE: To observe the effect of curcumin on the expression of PI3K (phosphatidylinositol-3-kinase, PI3K) and p-P3 K (phosphated phosphatidylinositol-3-kinase, p-PI3K) in the hippocampus of Alzheimer"s disease (AD) model (APP/PS1 double transgenic) mice.	Curcumin	36-44	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	72-101
23944055-1	2013	OBJECTIVE: To observe the effect of curcumin on the expression of PI3K (phosphatidylinositol-3-kinase, PI3K) and p-P3 K (phosphated phosphatidylinositol-3-kinase, p-PI3K) in the hippocampus of Alzheimer"s disease (AD) model (APP/PS1 double transgenic) mice.	Curcumin	36-44	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	132-161
23944055-1	2013	OBJECTIVE: To observe the effect of curcumin on the expression of PI3K (phosphatidylinositol-3-kinase, PI3K) and p-P3 K (phosphated phosphatidylinositol-3-kinase, p-PI3K) in the hippocampus of Alzheimer"s disease (AD) model (APP/PS1 double transgenic) mice.	Curcumin	36-44	presenilin 1	Mus musculus	229-232
23944055-18	2013	CONCLUSION: Curcumin can recover the decreased PI3K and p-PI3K and improve the insulin-signaling transmission in the hippocampus of APP/PS1 double transgenic mice.	Curcumin	12-20	presenilin 1	Mus musculus	136-139
23944058-1	2013	OBJECTIVE: Through the dynamic detection of the concentration change of the urine Alzheimer-associated neuronal thread protein (AD7C-NTP) in the curcumin treated Alzheimer"s disease (AD) model (APP/PS1 double transgenic) mice, the therapeutic effect of curcumin in AD was determined.	Curcumin	145-153	presenilin 1	Mus musculus	198-201
23552906-0	2013	Synthesis and biological evaluation of unsymmetrical curcumin analogues as tyrosinase inhibitors.	Curcumin	53-61	tyrosinase	Mus musculus	75-85
23524941-3	2013	Interestingly, a few natural PAK1-blockers such as curcumin, caffeic acid (CA) and rosmarinic acid (RA) extend the lifespan of the nematode Caenorhabditis elegans or fruit flies.	Curcumin	51-59	Serine/threonine-protein kinase pak-1	Caenorhabditis elegans	29-33
23063786-9	2013	Gene expression data from curcumin-fed larvae shows that the TOR pathway is inhibited in the larvae and the young to midlife adults, although several other genes involved in longevity extension are also affected.	Curcumin	26-34	Target of rapamycin	Drosophila melanogaster	61-64
23143785-6	2013	Curcumin"s pleiotropic activities emanate from its ability to modulate numerous signaling molecules such as pro-inflammatory cytokines, apoptotic proteins, NF-kappaB, cyclooxygenase-2, 5-LOX, STAT3, C-reactive protein, prostaglandin E(2), prostate-specific antigen, adhesion molecules, phosphorylase kinase, transforming growth factor-beta, triglyceride, ET-1, creatinine, HO-1, AST, and ALT in human participants.	Curcumin	0-8	kallikrein related peptidase 3	Homo sapiens	239-306
23991988-6	2013	RESULTS: We showed that the combination of curcumin and triptolide could synergistically inhibit ovarian cancer cell growth, and induce apoptosis, which is accompanied by HSP27 and HSP70, indicating that HSP27 and HSP70 play the important role in the synergic effect.	Curcumin	43-51	heat shock protein family B (small) member 1	Homo sapiens	171-176
23991988-6	2013	RESULTS: We showed that the combination of curcumin and triptolide could synergistically inhibit ovarian cancer cell growth, and induce apoptosis, which is accompanied by HSP27 and HSP70, indicating that HSP27 and HSP70 play the important role in the synergic effect.	Curcumin	43-51	heat shock protein family B (small) member 1	Homo sapiens	204-209
23218718-1	2013	A series of novel monocarbonyl analogues of curcumin have been designed, synthesized and tested for their activity against Molt4, HeLa, PC3, DU145 and KB cancer cell lines.	Curcumin	44-52	chromobox 8	Homo sapiens	136-139
23531214-5	2013	Antioxidant food additives such as sodium sulphite, sodium benzoate and curcumin were shown to suppress the leptin release in lipopolysaccharide- treated murine adipocytes.	Curcumin	72-80	leptin	Mus musculus	108-114
23305490-7	2013	The K2P channel blockers methanandamide, lidocaine, zinc and curcumin had antiproliferative effects (P &lt; 0.01) in an endometrial epithelial cancer cell line indicating a role for TASK and TREK-1 channels in proliferation.	Curcumin	61-69	keratin 76	Homo sapiens	4-7
24101950-0	2013	Therapeutic roles of heme oxygenase-1 in metabolic diseases: curcumin and resveratrol analogues as possible inducers of heme oxygenase-1.	Curcumin	61-69	heme oxygenase 1	Homo sapiens	120-136
24454990-8	2013	Furthermore, it was found that 24 h of incubation with curcumin increases by 1.4-, 2.3-, and 5.2-fold the activity of glutathione reductase, glutathione S-transferase and superoxide dismutase, respectively.	Curcumin	55-63	glutathione-disulfide reductase	Rattus norvegicus	118-139
24454990-8	2013	Furthermore, it was found that 24 h of incubation with curcumin increases by 1.4-, 2.3-, and 5.2-fold the activity of glutathione reductase, glutathione S-transferase and superoxide dismutase, respectively.	Curcumin	55-63	hematopoietic prostaglandin D synthase	Rattus norvegicus	141-166
23183190-0	2013	Inhibition effect of curcumin on TNF-alpha and MMP-13 expression induced by advanced glycation end products in chondrocytes.	Curcumin	21-29	tumor necrosis factor	Oryctolagus cuniculus	33-42
23183190-2	2013	In the present study, we examined the effect of curcumin, a pharmacologically safe phytochemical agent, on AGE-induced tumor necrosis factor-alpha (TNF-alpha) and matrix metalloproteinase-13 (MMP-13) in rabbit chondrocytes.	Curcumin	48-56	tumor necrosis factor	Oryctolagus cuniculus	148-157
23183190-8	2013	RESULTS: Curcumin significantly decreased AGE-stimulated TNF-alpha and MMP-13 mRNA and suppressed the NF-kB activation via inhibition of kBalpha (I-kBalpha) phosphorylation, I-kBalpha degradation and p65 nuclear translocation.	Curcumin	9-17	tumor necrosis factor	Oryctolagus cuniculus	57-66
23250811-0	2013	Curcumin improves TNBS-induced colitis in rats by inhibiting IL-27 expression via the TLR4/NF-kappaB signaling pathway.	Curcumin	0-8	interleukin 27	Rattus norvegicus	61-66
23250811-3	2013	This study explored whether curcumin improves colonic inflammation in a rat colitis model through inhibition of the TLR4/NF-kappaB signaling pathway and IL-27 expression.	Curcumin	28-36	interleukin 27	Rattus norvegicus	153-158
23250811-7	2013	Compared with the untreated colitis group, the curcumin-treated group showed significant decreases in the disease activity index, colonic mucosa damage index, histological score, myeloperoxidase activity, and expressions of NF-kappaB mRNA, IL-27 mRNA, TLR4 protein, NF-kappaB p65 protein, and IL-27 p28 protein (p &lt; 0.05).	Curcumin	47-55	myeloperoxidase	Rattus norvegicus	179-194
23250811-7	2013	Compared with the untreated colitis group, the curcumin-treated group showed significant decreases in the disease activity index, colonic mucosa damage index, histological score, myeloperoxidase activity, and expressions of NF-kappaB mRNA, IL-27 mRNA, TLR4 protein, NF-kappaB p65 protein, and IL-27 p28 protein (p &lt; 0.05).	Curcumin	47-55	interleukin 27	Rattus norvegicus	240-245
23250811-7	2013	Compared with the untreated colitis group, the curcumin-treated group showed significant decreases in the disease activity index, colonic mucosa damage index, histological score, myeloperoxidase activity, and expressions of NF-kappaB mRNA, IL-27 mRNA, TLR4 protein, NF-kappaB p65 protein, and IL-27 p28 protein (p &lt; 0.05).	Curcumin	47-55	interleukin 27	Rattus norvegicus	293-298
23250811-12	2013	The anti-inflammatory actions of curcumin on colitis may involve inhibition of the TLR4/NF-kappaB signaling pathway and of IL-27 expression.	Curcumin	33-41	interleukin 27	Rattus norvegicus	123-128
23544048-8	2013	Further, the effect of curcumin on alpha-SMA, PAI-1, E-cadherin, TbetaR I and TbetaR II were reversed by ERK inhibitor U0126 or PPARgamma inhibitor BADGE, or PPARgamma shRNA.	Curcumin	23-31	transforming growth factor beta receptor 1	Homo sapiens	65-73
23063543-6	2012	It was found that curcumin pretreatment significantly protected animals from T cell-mediated hepatitis as evidenced by decreased elevation of serum ALT, associated with reduced hepatic necrosis, apoptosis and mortality.	Curcumin	18-26	glutamic pyruvic transaminase, soluble	Mus musculus	148-151
23276558-0	2012	Effects of curcumin and demethoxycurcumin on amyloid-beta precursor and tau proteins through the internal ribosome entry sites: a potential therapeutic for Alzheimer"s disease.	Curcumin	11-19	microtubule associated protein tau	Homo sapiens	72-75
23276558-1	2012	OBJECTIVE: This study aims to determine the effects of curcumin and demethoxycurcumin on the internal ribosome entry site of the amyloid-beta precursor protein (APP) and tau protein through a bi-cistronic reporter assay for screening of anti-Alzheimer"s disease agents.	Curcumin	55-63	microtubule associated protein tau	Homo sapiens	170-173
23276558-5	2012	RESULTS: The bi-cistronic reporter assay revealed that curcumin was more effective than demethoxycurcumin, a structural analog of curcumin, in inhibiting both APP and tau IRES-dependent translation initiation.	Curcumin	55-63	microtubule associated protein tau	Homo sapiens	167-170
23276558-5	2012	RESULTS: The bi-cistronic reporter assay revealed that curcumin was more effective than demethoxycurcumin, a structural analog of curcumin, in inhibiting both APP and tau IRES-dependent translation initiation.	Curcumin	97-105	microtubule associated protein tau	Homo sapiens	167-170
23276558-6	2012	This result was further confirmed by Western blot analysis for the expression of APP C-terminal protein, human tau-1, pS(262) and pS(396) suggesting that curcumin may play a role in AD pathology alleviation through the inhibition of the APP and tau IRES-mediated translation mechanism.	Curcumin	154-162	microtubule associated protein tau	Homo sapiens	111-114
23351311-6	2012	The inhibition of cdk1 phosphorylation is one of alternative strategy which could selectively kill cancer cells and potentially be combined with DNA damaging agent such as curcumin.	Curcumin	172-180	cyclin dependent kinase 1	Homo sapiens	18-22
24076568-6	2013	With the inclusion of a novel derivative of curcumin, CDF, we showcase how natural agents can be effectively modified to increase their efficacy, particularly against CSCs.	Curcumin	44-52	LIF interleukin 6 family cytokine	Homo sapiens	54-57
23511143-0	2013	Localized leptin release may be an important mechanism of curcumin action after acute ischemic injuries.	Curcumin	58-66	leptin	Mus musculus	10-16
23511143-2	2013	Here, we investigated whether leptin and its signaling pathway mediate the protective effects of curcumin.	Curcumin	97-105	leptin	Mus musculus	30-36
23511143-4	2013	In vivo intestinal ischemia/reperfusion (I/R) injury in mice determined the effects of curcumin administration on inflammation, oxygen radical production, and leptin expression.	Curcumin	87-95	leptin	Mus musculus	159-165
23511143-10	2013	Interestingly, we found that the decreased leptin and its receptor Ob-Rb were restored by curcumin administration.	Curcumin	90-98	leptin	Mus musculus	43-49
23511143-11	2013	In addition, in vitro studies showed that curcumin increased leptin expression and release after hypoxia/reoxygenation-induced cell injuries.	Curcumin	42-50	leptin	Mus musculus	61-67
23511143-12	2013	Moreover, curcumin treatment restored decreased ERK1/2 phosphorylation (p-ERK1/2) and inhibited overactive p38 (p-p38) after injuries, and the effect was reversed by a leptin-specific antibody or Ob-R blocker.	Curcumin	10-18	leptin	Mus musculus	168-174
23511143-12	2013	Moreover, curcumin treatment restored decreased ERK1/2 phosphorylation (p-ERK1/2) and inhibited overactive p38 (p-p38) after injuries, and the effect was reversed by a leptin-specific antibody or Ob-R blocker.	Curcumin	10-18	leptin receptor	Mus musculus	196-200
23511143-13	2013	CONCLUSION: These data suggest that leptin and Ob-Rb-dependent ERK and p38 MAPK signaling pathways may be involved in curcumin protection against intestinal I/R injury, and leptin may be a potential target of curcumin in intestinal I/R injury and other related acute diseases.	Curcumin	118-126	leptin	Mus musculus	36-42
23511143-13	2013	CONCLUSION: These data suggest that leptin and Ob-Rb-dependent ERK and p38 MAPK signaling pathways may be involved in curcumin protection against intestinal I/R injury, and leptin may be a potential target of curcumin in intestinal I/R injury and other related acute diseases.	Curcumin	209-217	leptin	Mus musculus	36-42
23402943-9	2013	50mg/kg curcumin administration significantly ameliorated the hippocampal SOD activity, and increased the intensity of p-CaMKII in the stratum lucidum of hippocampal CA3 and p-NMDAR1 expression in the hippocampal membrane fraction of the SAMP8 mice.	Curcumin	8-16	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	176-182
23402943-10	2013	The present study demonstrated that curcumin treatment could attenuate cognitive deficits of SAMP8 mice in a dose-dependent manner by decreasing the oxidative stress and improving the expression of p-CaMKII and p-NMDAR1 in the hippocampus.	Curcumin	36-44	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	213-219
22820234-0	2012	Curcumin produces antidepressant effects via activating MAPK/ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice.	Curcumin	0-8	brain derived neurotrophic factor	Mus musculus	75-108
22820234-2	2012	The present study attempts to explore the mechanisms underlying the antidepressant-like action of curcumin by measuring the contents of brain derived neurotrophic factor (BDNF) in the amygdala of animal model of depression.	Curcumin	98-106	brain derived neurotrophic factor	Mus musculus	136-169
33294119-7	2020	Curcumin upregulates a variety of ferroptosis target genes related to redox regulation, especially heme oxygenase-1 (HO-1).	Curcumin	0-8	heme oxygenase 1	Homo sapiens	99-115
26105926-15	2013	IL-8 was inhibited up to 67% by the liposomal curcumin in human vaginal cell lines (End1/E6E7, Ect1/E6E7, VK2/E6E7) as compared to curcumin.	Curcumin	46-54	fibroblast growth factor receptor 2	Homo sapiens	95-99
22820234-2	2012	The present study attempts to explore the mechanisms underlying the antidepressant-like action of curcumin by measuring the contents of brain derived neurotrophic factor (BDNF) in the amygdala of animal model of depression.	Curcumin	98-106	brain derived neurotrophic factor	Mus musculus	171-175
33294119-7	2020	Curcumin upregulates a variety of ferroptosis target genes related to redox regulation, especially heme oxygenase-1 (HO-1).	Curcumin	0-8	heme oxygenase 1	Homo sapiens	117-121
22820234-5	2012	Chronic administration of curcumin (40 mg/kg, i.p., 21 days) increased BDNF protein levels in the amygdala and this enhancement was suppressed by pretreatment with the extracellular signal-regulated kinase (ERK) inhibitor SL327.	Curcumin	26-34	brain derived neurotrophic factor	Mus musculus	71-75
33294119-9	2020	Therefore, these data demonstrate that curcumin triggers the molecular and cytological characteristics of ferroptosis in breast cancer cells, and HO-1 promotes curcumin-induced ferroptosis.	Curcumin	160-168	heme oxygenase 1	Homo sapiens	146-150
22820234-8	2012	These results suggest that the antidepressant-like effects of curcumin in the forced swim test are mediated, at least in part, by an ERK-regulated increase of BDNF expression in the amygdala of mice.	Curcumin	62-70	brain derived neurotrophic factor	Mus musculus	159-163
33184252-7	2020	RESULTS The rpS6-phosphorylation was suppressed and light chain 3 (LC3II) expression elevated in the curcumin treated group of the fracture rat model.	Curcumin	101-109	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	67-72
22890189-3	2012	Anionic polymerization method was employed for the preparation of apolipoprotein-E3 mediated curcumin loaded poly(butyl)cyanoacrylate nanoparticles (ApoE3-C-PBCA) and characterized for size, zeta potential, entrapment efficiency, photostability, morphology, and in vitro release study.	Curcumin	93-101	PBCA	Homo sapiens	157-161
22890189-4	2012	ApoE3-C-PBCA were found to be effective against SH-SY5Y neuroblastoma cells compared to curcumin solution (CSSS) and curcumin loaded PBCA nanoparticles (C-PBCA) from in vitro cell culture investigations.	Curcumin	117-125	PBCA	Homo sapiens	133-137
22890189-4	2012	ApoE3-C-PBCA were found to be effective against SH-SY5Y neuroblastoma cells compared to curcumin solution (CSSS) and curcumin loaded PBCA nanoparticles (C-PBCA) from in vitro cell culture investigations.	Curcumin	117-125	PBCA	Homo sapiens	133-137
23467542-5	2013	Both NF-kappaB inhibitor PDTC (20 muM) and AP-1 inhibitor curcumin (25 mM) could attenuate TF expression induced by anti-beta2GPI/beta2GPI or APS-IgG/beta2GPI complex.	Curcumin	58-66	coagulation factor III, tissue factor	Homo sapiens	91-93
23467542-5	2013	Both NF-kappaB inhibitor PDTC (20 muM) and AP-1 inhibitor curcumin (25 mM) could attenuate TF expression induced by anti-beta2GPI/beta2GPI or APS-IgG/beta2GPI complex.	Curcumin	58-66	apolipoprotein H	Homo sapiens	121-129
22890189-5	2012	Flow cytometry techniques employed for the detection of anticancer activity revealed enhanced activity of curcumin against SH-SY5Y neuroblastoma cells with ApoE3-C-PBCA compared to CSSS and C-PBCA, and apoptosis being the underlying mechanism.	Curcumin	106-114	PBCA	Homo sapiens	164-168
33184252-10	2020	Treatment of rats with curcumin significantly (P<0.05) promoted expression of PCNA and VEGF.	Curcumin	23-31	vascular endothelial growth factor A	Rattus norvegicus	87-91
22922731-0	2012	Curcumin inhibits HCV replication by induction of heme oxygenase-1 and             suppression of AKT.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	50-66
23467542-5	2013	Both NF-kappaB inhibitor PDTC (20 muM) and AP-1 inhibitor curcumin (25 mM) could attenuate TF expression induced by anti-beta2GPI/beta2GPI or APS-IgG/beta2GPI complex.	Curcumin	58-66	apolipoprotein H	Homo sapiens	130-138
23467542-5	2013	Both NF-kappaB inhibitor PDTC (20 muM) and AP-1 inhibitor curcumin (25 mM) could attenuate TF expression induced by anti-beta2GPI/beta2GPI or APS-IgG/beta2GPI complex.	Curcumin	58-66	apolipoprotein H	Homo sapiens	130-138
22922731-5	2012	Under the same conditions, curcumin also dose-dependently induced heme oxygenase-1 with the highest induction at 24 h. Hemin, a heme oxygenase-1 inducer, also inhibited HCV protein expression in a dose-dependent manner.	Curcumin	27-35	heme oxygenase 1	Homo sapiens	66-82
32738342-11	2020	This study provided evidences for the effect of curcumin on the expression of MAT2B, an enzyme for the biosynthesis of methyl donor S-adenosylmethionine, in HSCs and demonstrated the function significance of curcumin-induced downregulation of MAT2B in curcumin inhibition of liver fibrosis.	Curcumin	48-56	methionine adenosyltransferase II, beta	Mus musculus	243-248
22922731-5	2012	Under the same conditions, curcumin also dose-dependently induced heme oxygenase-1 with the highest induction at 24 h. Hemin, a heme oxygenase-1 inducer, also inhibited HCV protein expression in a dose-dependent manner.	Curcumin	27-35	heme oxygenase 1	Homo sapiens	128-144
22922731-6	2012	The knockdown of heme oxygenase-1 partially reversed the curcumin-inhibited HCV protein expression.	Curcumin	57-65	heme oxygenase 1	Homo sapiens	17-33
22922731-7	2012	In addition to the heme oxygenase-1 induction, signaling molecule activities of AKT, extracellular signal-regulated kinases (ERK) and nuclear factor-kappaB (NF-kappaB) were inhibited by curcumin.	Curcumin	186-194	heme oxygenase 1	Homo sapiens	19-35
22922731-10	2012	In summary, curcumin inhibited HCV replication by heme oxygenase-1 induction and AKT pathway inhibition.	Curcumin	12-20	heme oxygenase 1	Homo sapiens	50-66
23341182-4	2013	The DM-1 compound is a curcumin analog that possesses several curcumin characteristics, such as antiproliferative, antitumor, and anti-metastatic properties.	Curcumin	23-31	immunoglobulin heavy diversity 1-7	Homo sapiens	4-8
23341182-4	2013	The DM-1 compound is a curcumin analog that possesses several curcumin characteristics, such as antiproliferative, antitumor, and anti-metastatic properties.	Curcumin	62-70	immunoglobulin heavy diversity 1-7	Homo sapiens	4-8
32738342-11	2020	This study provided evidences for the effect of curcumin on the expression of MAT2B, an enzyme for the biosynthesis of methyl donor S-adenosylmethionine, in HSCs and demonstrated the function significance of curcumin-induced downregulation of MAT2B in curcumin inhibition of liver fibrosis.	Curcumin	208-216	methionine adenosyltransferase II, beta	Mus musculus	78-83
32738342-11	2020	This study provided evidences for the effect of curcumin on the expression of MAT2B, an enzyme for the biosynthesis of methyl donor S-adenosylmethionine, in HSCs and demonstrated the function significance of curcumin-induced downregulation of MAT2B in curcumin inhibition of liver fibrosis.	Curcumin	208-216	methionine adenosyltransferase II, beta	Mus musculus	243-248
23509976-0	2013	Curcumin modulates alpha-synuclein aggregation and toxicity.	Curcumin	0-8	synuclein alpha	Homo sapiens	19-34
23509976-3	2013	While curcumin has been shown to significantly reduce cell toxicity of alpha-Syn aggregates, its mechanism of action remains unexplored.	Curcumin	6-14	synuclein alpha	Homo sapiens	71-80
32738342-11	2020	This study provided evidences for the effect of curcumin on the expression of MAT2B, an enzyme for the biosynthesis of methyl donor S-adenosylmethionine, in HSCs and demonstrated the function significance of curcumin-induced downregulation of MAT2B in curcumin inhibition of liver fibrosis.	Curcumin	208-216	methionine adenosyltransferase II, beta	Mus musculus	78-83
23509976-6	2013	The degree of curcumin binding correlates with the extent of alpha-Syn oligomerization, suggesting that the ordered structure of protein is required for effective curcumin binding.	Curcumin	14-22	synuclein alpha	Homo sapiens	61-70
22402367-7	2012	In CMs, TLR2 and monocyte chemoattractant protein (MCP)-1 mRNAs were increased by TNF-alpha, PGN or H/R, whereas they were blunted by curcumin.	Curcumin	134-142	C-C motif chemokine ligand 2	Rattus norvegicus	17-57
23509976-6	2013	The degree of curcumin binding correlates with the extent of alpha-Syn oligomerization, suggesting that the ordered structure of protein is required for effective curcumin binding.	Curcumin	163-171	synuclein alpha	Homo sapiens	61-70
32738342-11	2020	This study provided evidences for the effect of curcumin on the expression of MAT2B, an enzyme for the biosynthesis of methyl donor S-adenosylmethionine, in HSCs and demonstrated the function significance of curcumin-induced downregulation of MAT2B in curcumin inhibition of liver fibrosis.	Curcumin	208-216	methionine adenosyltransferase II, beta	Mus musculus	243-248
23509976-7	2013	The acceleration of aggregation by curcumin may decrease the population of toxic oligomeric intermediates of alpha-Syn.	Curcumin	35-43	synuclein alpha	Homo sapiens	109-118
33152924-7	2020	When curcumin and melatonin were given together, the ameliorative effect was augmented in some of the measured indices e.g. tumor necrosis factor alpha, cystatin C, uric acid, phosphorus in plasma and, urine creatinine and creatinine clearance.	Curcumin	5-13	cystatin C	Rattus norvegicus	153-163
22554269-8	2013	Curcumin may decrease alveolar bone loss in the experimental periodontitis rats via suppressing the expression of RANKL/RANK/OPG and its anti-inflammatory properties.	Curcumin	0-8	TNF receptor superfamily member 11B	Rattus norvegicus	125-128
23095512-7	2012	METHODS: Cell loss was assayed after TE-1, TE-8, KY-5, KY-10, YES-1, and YES-2 cells were exposed to 20-80 muM curcumin for 30 hrs.	Curcumin	111-119	YES1 pseudogene 1	Homo sapiens	73-78
23095512-16	2012	The curcumin-surviving lines showed a significant loss in the high staining ALDH1A1 and CD44 cell populations.	Curcumin	4-12	aldehyde dehydrogenase 1 family member A1	Homo sapiens	76-83
23442673-3	2012	Moreover, curcumin regulated urate transport-related proteins and inhibited activation of the JAK2-STAT3 cascade and overexpression of SOCS3 and TGF-beta1 in the kidneys of fructose-fed rats.	Curcumin	10-18	signal transducer and activator of transcription 3	Rattus norvegicus	99-104
23442673-4	2012	These results suggested that the anti-hyperuricaemic and renal protective actions of curcumin might be the result of renal NO-mediated JAK2-STAT3 signalling and TGF-beta1 normality, which ameliorated renal endothelial dysfunction to improve renal urate transporter system in this model.	Curcumin	85-93	signal transducer and activator of transcription 3	Rattus norvegicus	140-145
24744464-0	2013	Endurance exercise training and diferuloyl methane supplement: changes in neurotrophic factor and oxidative stress induced by lead in rat brain.	Curcumin	32-50	neurotrophin 3	Rattus norvegicus	74-93
32961574-7	2020	Moreover, the inhibitory effects of curcumin on the levels of HIF-1 and HIF-2alpha protein in CS-LCs were investigated using the western blot method.	Curcumin	36-44	endothelial PAS domain protein 1	Homo sapiens	72-82
32961574-10	2020	Based on the results, the curcumin inhibited the expression of HIF-1 by degrading ARNT in CS-LCs.In conclusion, curcumin has inhibitory effects on MCF- 7 cells and CS- LCs and thus may be used as an antitumor agent.	Curcumin	26-34	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	82-86
22674286-11	2012	Thrombin-mediated CCL2 production was attenuated by the thrombin inhibitor PPACK, the protein kinase Cdelta (PKCdelta) inhibitor rottlerin, the c-Src inhibitor PP2, epidermal growth factor receptor (EGFR) inhibitor AG-1478, MEK inhibitors PD98059 and U0126, or AP-1 inhibitors curcumin and tanshinone IIA.	Curcumin	277-285	C-C motif chemokine ligand 2	Homo sapiens	18-22
32961574-10	2020	Based on the results, the curcumin inhibited the expression of HIF-1 by degrading ARNT in CS-LCs.In conclusion, curcumin has inhibitory effects on MCF- 7 cells and CS- LCs and thus may be used as an antitumor agent.	Curcumin	112-120	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	82-86
23448582-0	2013	Curcumin improves expression of SCF/c-kit through attenuating oxidative stress and NF-kappaB activation in gastric tissues of diabetic gastroparesis rats.	Curcumin	0-8	KIT ligand	Rattus norvegicus	32-35
32745765-0	2020	Hypoxic preconditioning combined with curcumin promotes cell survival and mitochondrial quality of bone marrow mesenchymal stem cells, and accelerates cutaneous wound healing via PGC-1alpha/SIRT3/ HIF-1alpha signaling.	Curcumin	38-46	sirtuin 3	Mus musculus	190-195
23448582-12	2013	In addition, curcumin-treated diabetic rats showed significantly increased levels of SCF/c-kit protein in stomach tissues, inhibited I-kappaB degradation and NF-kappaB activation, and reduced ICC apoptosis index [(26.2 +- 4.1)% vs (47.5 +- 6.2)%], compared with the diabetic group.	Curcumin	13-21	KIT ligand	Rattus norvegicus	85-88
23448582-13	2013	CONCLUSION: Curcumin treatment improved gastric emptying by blocking the production of oxidative stress, abolishing NF-kappaB signal transduction and enhancing expression of SCF/c-kit in rats with diabetic gastroparesis.	Curcumin	12-20	KIT ligand	Rattus norvegicus	174-177
22902770-0	2012	Effects of curcumin on levels of nitric oxide synthase and AQP-4 in a rat model of hypoxia-ischemic brain damage.	Curcumin	11-19	aquaporin 4	Rattus norvegicus	59-64
22902770-4	2012	Curcumin injection, but not the control DMSO injection, partially reversed HIBD-induced brain edema and morphological changes, as well as HIBD-induced increase in NOS activities and AQP-4 expression (P&lt;0.05).	Curcumin	0-8	aquaporin 4	Rattus norvegicus	182-187
22902770-6	2012	Curcumin may protect the BBB ultrastructure and thus decrease brain edema following HIBD by down-regulating HIBD-induced increase in NOS activities and AQP-4 protein expression.	Curcumin	0-8	aquaporin 4	Rattus norvegicus	152-157
32745765-7	2020	At the mechanistic level, the destabilization of HIF-1alpha and the up-regulated expression of PGC-1alpha and SIRT3 synergistically contributed to the protective effects of hypoxic preconditioning combined with curcumin in BMSCs.	Curcumin	211-219	hypoxia inducible factor 1, alpha subunit	Mus musculus	49-59
23333261-9	2013	Moreover, curcumin alleviated Sim2 expression, and reversely raised Drebrin expression in neurons treated with hyperglycaemia.	Curcumin	10-18	SIM bHLH transcription factor 2	Rattus norvegicus	30-34
32745765-7	2020	At the mechanistic level, the destabilization of HIF-1alpha and the up-regulated expression of PGC-1alpha and SIRT3 synergistically contributed to the protective effects of hypoxic preconditioning combined with curcumin in BMSCs.	Curcumin	211-219	sirtuin 3	Mus musculus	110-115
23294827-7	2013	Peptides pulled down from this reaction were sequenced and it was determined that biotinylated curcumin bound hsp70, hsp90, 3-phosphoglycerate dehydrogenase, and a beta-actin variant.	Curcumin	95-103	heat shock protein 90 alpha family class A member 1	Homo sapiens	117-122
32745765-10	2020	Furthermore, knockdown of SIRT3 and PGC-1alpha by RNAi both led to caspase-3 activation in BMSCs after hypoxia and curcumin treatment.	Curcumin	115-123	sirtuin 3	Mus musculus	26-31
22875542-18	2013	On the other hand, pretreatment with curcumin significantly increased renal M6PRBP-1 and NEDD-4 expression.	Curcumin	37-45	neural precursor cell expressed, developmentally down-regulated 4	Mus musculus	89-95
32898599-5	2020	Furthermore, curcumin attenuated OLA-induced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and liver damage in mice.	Curcumin	13-21	glutamic pyruvic transaminase, soluble	Mus musculus	51-75
24117066-0	2013	Curcumin induces ABCA1 expression and apolipoprotein A-I-mediated cholesterol transmembrane in the chronic cerebral hypoperfusion aging rats.	Curcumin	0-8	apolipoprotein A1	Rattus norvegicus	38-56
24117066-8	2013	Meanwhile, the expression of LXR-beta, RXR-alpha, ABCA1 and apoA-I mRNA and protein were increased in a dose-dependent manner after curcumin treatment.	Curcumin	132-140	apolipoprotein A1	Rattus norvegicus	60-66
22887959-0	2012	Curcumin analogues with potent and selective anti-proliferative activity on acute promyelocytic leukemia: involvement of accumulated misfolded nuclear receptor co-repressor (N-CoR) protein as a basis for selective activity.	Curcumin	0-8	nuclear receptor corepressor 1	Homo sapiens	143-172
24117066-10	2013	We conclude that curcumin has the ability to activate permissive LXR-beta/RXR-alpha signaling and thereby modulate ABCA1 and apoA-I-mediated cholesterol transmembrane transportation, which is a new preventive and therapeutic strategy for cerevascular diseases.	Curcumin	17-25	apolipoprotein A1	Rattus norvegicus	125-131
22887959-0	2012	Curcumin analogues with potent and selective anti-proliferative activity on acute promyelocytic leukemia: involvement of accumulated misfolded nuclear receptor co-repressor (N-CoR) protein as a basis for selective activity.	Curcumin	0-8	nuclear receptor corepressor 1	Homo sapiens	174-179
32898599-5	2020	Furthermore, curcumin attenuated OLA-induced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and liver damage in mice.	Curcumin	13-21	glutamic pyruvic transaminase, soluble	Mus musculus	77-80
22887959-1	2012	Curcumin arrests the proliferation of acute promyelocytic leukemia (APL) cells by stabilizing the misfolded nuclear receptor co-repressor (N-CoR) protein, thereby sensitizing APL cells to apoptosis induced by the unfolded protein response.	Curcumin	0-8	nuclear receptor corepressor 1	Homo sapiens	108-137
22887959-1	2012	Curcumin arrests the proliferation of acute promyelocytic leukemia (APL) cells by stabilizing the misfolded nuclear receptor co-repressor (N-CoR) protein, thereby sensitizing APL cells to apoptosis induced by the unfolded protein response.	Curcumin	0-8	nuclear receptor corepressor 1	Homo sapiens	139-144
32898599-8	2020	Moreover, curcumin pretreatment significantly up-regulated the expressions of nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1(HO-1) and down-regulated the expressions of nuclear factor- kappaB (NF-kB) and p53 through reduced the nuclear translocation of NF-kB induced by OLA.	Curcumin	10-18	transformation related protein 53, pseudogene	Mus musculus	229-232
22887959-2	2012	This phenomenon was attributed to inhibition of the proteasomal and protease-induced breakdown of misfolded N-CoR by curcumin.	Curcumin	117-125	nuclear receptor corepressor 1	Homo sapiens	108-113
31983246-0	2020	Thymoquinone and Curcumin combination protects cisplatin-induced Kidney Injury, Nephrotoxicity by attenuating NFkB, KIM-1 and ameliorating Nrf2/HO-1 signaling.	Curcumin	17-25	heme oxygenase 1	Homo sapiens	144-148
23886126-5	2013	The mixture of curcumin and silibinin showed relatively more inhibitory effect on growth of T47D cells and hTERT gene expression as compared with either agent alone.	Curcumin	15-23	telomerase reverse transcriptase	Homo sapiens	107-112
32338107-12	2020	We verified the direct regulation of PTEN by miR-181a in cultured human embryonic kidney 293T cells.Conclusions: We showed the involvement of miR-181a/PTEN axis in the renoprotective effect of curcumin against cisplatin-induced AKI, and provide new evidence on the ability of curcumin to alleviate cisplatin-induced nephrotoxicity.	Curcumin	193-201	phosphatase and tensin homolog	Homo sapiens	37-41
23886126-6	2013	CONCLUSIONS: These findings suggest that cell viability along with hTERT gene expression in breast cancer cells could be reduced by curcumin and silibinin.	Curcumin	132-140	telomerase reverse transcriptase	Homo sapiens	67-72
23325575-7	2013	Curcumin up-regulated expression of SOD genes and down-regulated expression of several age-related genes, such as dInR, ATTD, Def, CecB, and DptB.	Curcumin	0-8	Attacin-D	Drosophila melanogaster	120-124
22924511-4	2012	In this article we summarize tau-based natural products as AD therapeutics from a variety of biological sources, including the anti-amyloid agent curcumin, isolated from turmeric, the microtubule stabilizer paclitaxel, from the Pacific Yew Taxus brevifolia, and the Streptomyces-derived Hsp90 inhibitor, geldanamycin.	Curcumin	146-154	microtubule associated protein tau	Homo sapiens	29-32
32338107-12	2020	We verified the direct regulation of PTEN by miR-181a in cultured human embryonic kidney 293T cells.Conclusions: We showed the involvement of miR-181a/PTEN axis in the renoprotective effect of curcumin against cisplatin-induced AKI, and provide new evidence on the ability of curcumin to alleviate cisplatin-induced nephrotoxicity.	Curcumin	193-201	phosphatase and tensin homolog	Homo sapiens	151-155
22749847-4	2012	In the present study, curcumin inhibition of the suppressive activity of CD4(+)CD25(+) regulatory T cells appears to be dependent on three categories: inhibiting cell-cell contact by down-regulation of CTLA-4, suppressing inhibitory cytokine secretion and decreasing the ability to consume IL-2 and/or suppress IL-2 production.	Curcumin	22-30	interleukin 2	Mus musculus	290-294
22749847-4	2012	In the present study, curcumin inhibition of the suppressive activity of CD4(+)CD25(+) regulatory T cells appears to be dependent on three categories: inhibiting cell-cell contact by down-regulation of CTLA-4, suppressing inhibitory cytokine secretion and decreasing the ability to consume IL-2 and/or suppress IL-2 production.	Curcumin	22-30	interleukin 2	Mus musculus	311-315
22749847-5	2012	In addition, Foxp3 expression was also reduced on Tregs after curcumin stimulation.	Curcumin	62-70	forkhead box P3	Mus musculus	13-18
23843878-0	2013	Curcumin Protects against 1-Methyl-4-phenylpyridinium Ion- and Lipopolysaccharide-Induced Cytotoxicities in the Mouse Mesencephalic Astrocyte via Inhibiting the Cytochrome P450 2E1.	Curcumin	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	161-180
23843878-5	2013	Moreover, curcumin significantly inhibited the cytochrome P450 2E1 (CYP2E1) expression (P &lt; 0.01 at mRNA level, P &lt; 0.05 at protein level) and its activity (P &lt; 0.05) sufficiently induced by MPP(+) and LPS in the mouse mesencephalic astrocytes.	Curcumin	10-18	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	47-66
32822714-8	2020	Curcumin, quercetin, and atorvastatin treatment lead to down-regulation of miR-21 and TGFbeta1 and up-regulation of miR-122 in the BDL groups.	Curcumin	0-8	microRNA 122	Rattus norvegicus	116-123
23843878-5	2013	Moreover, curcumin significantly inhibited the cytochrome P450 2E1 (CYP2E1) expression (P &lt; 0.01 at mRNA level, P &lt; 0.05 at protein level) and its activity (P &lt; 0.05) sufficiently induced by MPP(+) and LPS in the mouse mesencephalic astrocytes.	Curcumin	10-18	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	68-74
23843878-7	2013	Accordingly, curcumin protects against MPP(+)- and LPS-induced cytotoxicities in the mouse mesencephalic astrocyte via inhibiting the CYP2E1 expression and activity.	Curcumin	13-21	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	134-140
33104076-12	2020	This method was used to test the inhibition potency of curcumin using GSTs from equine liver.	Curcumin	55-63	glutathione S-transferase kappa 1	Homo sapiens	70-74
23489691-0	2013	Curcumin induces apoptosis in breast cancer cell lines and delays the growth of mammary tumors in neu transgenic mice.	Curcumin	0-8	erb-b2 receptor tyrosine kinase 2	Mus musculus	98-101
22749847-6	2012	Moreover, we found that nuclear translocation of p65 and c-Rel, which is critical for Foxp3 and CD25 expressions, was markedly decreased in Tregs with curcumin stimulation.	Curcumin	151-159	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	49-52
22749847-6	2012	Moreover, we found that nuclear translocation of p65 and c-Rel, which is critical for Foxp3 and CD25 expressions, was markedly decreased in Tregs with curcumin stimulation.	Curcumin	151-159	reticuloendotheliosis oncogene	Mus musculus	57-62
22749847-6	2012	Moreover, we found that nuclear translocation of p65 and c-Rel, which is critical for Foxp3 and CD25 expressions, was markedly decreased in Tregs with curcumin stimulation.	Curcumin	151-159	forkhead box P3	Mus musculus	86-91
22653966-3	2012	Curcumin induces the activation of caspase-8, -2, and -9, alteration of mitochondrial membrane potential, release of cytochrome c, and activation of caspase-3 and concomitant PARP cleavage, but the addition of caspase inhibitors only partially blocked the curcumin-mediated apoptosis.	Curcumin	0-8	caspase 2	Homo sapiens	35-42
33083489-0	2020	Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL-1beta, and TNF-alpha in Chronic Periodontitis Patients.	Curcumin	12-20	interleukin 1 alpha	Homo sapiens	53-61
22410671-0	2012	Curcumin inhibits LPS-induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells.	Curcumin	0-8	C-C motif chemokine ligand 2	Rattus norvegicus	30-34
22864626-2	2013	Piperine is known to enhance the bioavailability of curcumin, as a substrate of P-gp by at least 2000%.	Curcumin	52-60	PGP	Canis lupus familiaris	80-84
33083489-2	2020	The study is aimed at evaluating the effect of curcumin gel on serum levels of micronutrients (zinc, copper, and magnesium) and proinflammatory cytokines (IL-1beta and TNF-alpha) in chronic periodontitis patients.	Curcumin	47-55	interleukin 1 alpha	Homo sapiens	155-163
22410671-0	2012	Curcumin inhibits LPS-induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells.	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	50-53
32718261-5	2020	The results indicated that PE and/or curcumin attenuated TAA-induced liver fibrogenesis, as evidenced by significant improvement in the liver function tests (AST, ALT, ALP, and albumin), oxidative stress biomarkers (MDA, SOD, and GSH), and inflammatory biomarkers (NF-kB, TNF-alpha, IL-1beta, iNOS, TGF-beta, and MPO), compared to TAA group.	Curcumin	37-45	myeloperoxidase	Rattus norvegicus	313-316
32718261-6	2020	Moreover, treatment with PE and/or curcumin exerted a significant upregulation of Nrf2/HO-1 gene expressions along with significant downregulation of NF-kB, TGF-beta, and phospho-Smad3 protein expressions, as well as alpha-SMA and collagen-1 gene expressions.	Curcumin	35-43	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	150-155
32993709-0	2020	Curcumin derivative C212 inhibits Hsp90 and eliminates both growing and quiescent leukemia cells in deep dormancy.	Curcumin	0-8	heat shock protein 90 alpha family class A member 1	Homo sapiens	34-39
22634334-0	2012	Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells.	Curcumin	0-8	thioredoxin	Homo sapiens	23-34
22634334-7	2012	Herein we reported that curcumin can target the cytosolic/nuclear thioredoxin system to eventually elevate oxidative stress in HeLa cells.	Curcumin	24-32	thioredoxin	Homo sapiens	66-77
22634334-9	2012	Also, curcumin can drastically down-regulate Trx1 protein level as well as its enzyme activity in HeLa cells, which in turn remarkably decreases intracellular free thiols, shifting the intracellular redox balance to a more oxidative state, and subsequently induces DNA oxidative damage.	Curcumin	6-14	thioredoxin	Homo sapiens	45-49
22561298-5	2012	Both salusin-beta-induced VCAM-1 induction and monocyte/HUVEC adhesion were suppressed by pharmacological inhibitors of NF-kappaB, e.g., Bay 11-7682 and curcumin.	Curcumin	153-161	vascular cell adhesion molecule 1	Mus musculus	26-32
23909733-5	2013	Pretreatment of curcumin and curcumin plus piperine before administration of BaP significantly decreased the activities of EROD, PROD, and the level of BaPDE-DNA adducts with consequent increase in QR activities.	Curcumin	16-24	prohibitin 2	Mus musculus	77-80
23909733-5	2013	Pretreatment of curcumin and curcumin plus piperine before administration of BaP significantly decreased the activities of EROD, PROD, and the level of BaPDE-DNA adducts with consequent increase in QR activities.	Curcumin	16-24	crystallin, zeta	Mus musculus	198-200
23909733-5	2013	Pretreatment of curcumin and curcumin plus piperine before administration of BaP significantly decreased the activities of EROD, PROD, and the level of BaPDE-DNA adducts with consequent increase in QR activities.	Curcumin	29-37	prohibitin 2	Mus musculus	77-80
23909733-5	2013	Pretreatment of curcumin and curcumin plus piperine before administration of BaP significantly decreased the activities of EROD, PROD, and the level of BaPDE-DNA adducts with consequent increase in QR activities.	Curcumin	29-37	crystallin, zeta	Mus musculus	198-200
23533564-4	2013	METHODOLOGY: Curcumin and its 12 derivatives were tested for their potencies of inhibitory effects on human and rat 11beta-HSD1 with selectivity against 11beta-HSD2.	Curcumin	13-21	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	153-164
23533564-12	2013	In conclusion, curcumin is effective for the treatment of metabolic syndrome and four novel curcumin derivatives had high potencies for inhibition of human 11beta-HSD1 with selectivity against 11beta-HSD2.	Curcumin	92-100	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	193-204
23437361-7	2013	The expression of IL-6, IL-10, IFNgamma, and MCP-1, key chemokines/cytokines implicated in the development of ALI/ARDS, from both the inflammatory infiltrate and whole lung tissue were modulated by curcumin potentially through a reduction in the phosphorylated form of NFkappaB p65.	Curcumin	198-206	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	278-281
23042094-5	2012	We show that curcumin inhibits translocation of NFkappaB to the nucleus through the inhibition of the IkappaB-kinase (IKKbeta, leading to stabilization of the inhibitor of NFkappaB, IkappaBalpha, in PC-3 prostate carcinoma cells.	Curcumin	13-21	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	118-125
23042094-8	2012	Treatment of the cells with curcumin and siRNA-based knockdown of CXCL1 and -2 induce apoptosis, inhibit proliferation and downregulate several important metastasis-promoting factors like COX2, SPARC and EFEMP.	Curcumin	28-36	secreted protein acidic and cysteine rich	Homo sapiens	194-199
22672984-1	2012	Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens.	Curcumin	77-85	chromobox 8	Homo sapiens	62-66
33061449-0	2020	Curcumin Negatively Regulates Cigarette Smoke-Induced Renal Cell Carcinoma Epithelial-Mesenchymal Transition Through the ERK5/AP-1 Pathway.	Curcumin	0-8	mitogen-activated protein kinase 7	Homo sapiens	121-125
23194063-9	2012	CONCLUSIONS: These results identify a new and highly potent curcumin derivative and demonstrate that in cells where curcumin and RL197 induce ROS, an important underlying mechanism of action involves perturbation of miR-ZBTB10/ZBTB4, resulting in the induction of these repressors which downregulate Sp transcription factors and Sp-regulated genes.	Curcumin	60-68	zinc finger and BTB domain containing 10	Homo sapiens	220-226
23194063-9	2012	CONCLUSIONS: These results identify a new and highly potent curcumin derivative and demonstrate that in cells where curcumin and RL197 induce ROS, an important underlying mechanism of action involves perturbation of miR-ZBTB10/ZBTB4, resulting in the induction of these repressors which downregulate Sp transcription factors and Sp-regulated genes.	Curcumin	116-124	zinc finger and BTB domain containing 10	Homo sapiens	220-226
33061449-11	2020	Furthermore, curcumin showed the same inhibitory effect as XMD8-92 and significantly reversed CS-induced EMT through inhibiting the ERK5/AP-1 signaling pathway.	Curcumin	13-21	mitogen-activated protein kinase 7	Homo sapiens	132-136
22449710-3	2012	In this study, we observed a close connection between dephosphorylated Akt and an increase in phosphorylated heat shock protein 27 (HSP27) during combined treatment with curcumin and TRAIL.	Curcumin	170-178	heat shock protein family B (small) member 1	Homo sapiens	109-130
22975311-0	2012	Constitutive autotaxin transcription by Nmyc-amplified and non-amplified neuroblastoma cells is regulated by a novel AP-1 and SP-mediated mechanism and abrogated by curcumin.	Curcumin	165-173	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	40-44
33014113-0	2020	Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal Cancer Cells through Its Effects on miR-409-3p.	Curcumin	0-8	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	19-24
22840386-0	2012	Curcumin attenuates rat thoracic aortic aneurysm formation by inhibition of the c-Jun N-terminal kinase pathway and apoptosis.	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	80-103
22840386-3	2012	We sought to investigate whether curcumin could inhibit JNK pathways and apoptosis in thoracic aortic aneurysms.	Curcumin	33-41	mitogen-activated protein kinase 8	Rattus norvegicus	56-59
22840386-7	2012	Most importantly, curcumin treatment significantly inhibited the phosphorylation of JNK and c-Jun, accompanied by less cell apoptosis in thoracic aortic aneurysm tissues.	Curcumin	18-26	mitogen-activated protein kinase 8	Rattus norvegicus	84-87
22840386-8	2012	Furthermore, the expression levels of caspase-3 and the Bax/Bcl-2 ratio were significantly decreased in the aortic walls of curcumin-treated rats.	Curcumin	124-132	BCL2 associated X, apoptosis regulator	Rattus norvegicus	56-59
22840386-9	2012	CONCLUSION: The present study indicates that the beneficial effect of curcumin on degenerative aortic aneurysms is related to the inhibition of JNK and apoptosis in the walls of thoracic aortic aneurysms.	Curcumin	70-78	mitogen-activated protein kinase 8	Rattus norvegicus	144-147
22156994-10	2012	In the preclinical trial with rodent models, curcumin reduced Stat3-P and the proliferative markers CycD1 and Mcm2 in mice lung tissues in vivo.	Curcumin	45-53	minichromosome maintenance complex component 2	Mus musculus	110-114
22449710-3	2012	In this study, we observed a close connection between dephosphorylated Akt and an increase in phosphorylated heat shock protein 27 (HSP27) during combined treatment with curcumin and TRAIL.	Curcumin	170-178	heat shock protein family B (small) member 1	Homo sapiens	132-137
22520056-8	2012	Treatment with curcumin significantly attenuated the CLP-induced pulmonary edema and inflammation, as it significantly decreased lung W/D ratio, protein concentration, and the accumulation of the inflammatory cells in the BALF, as well as pulmonary MPO activity.	Curcumin	15-23	myeloperoxidase	Rattus norvegicus	249-252
22498762-9	2012	In addition, the expression of anti-apoptotic proteins (IAP1, IAP2, Bcl-X(L)) was up-regulated by TNF-alpha but suppressed by curcumin in HaCaT cells.	Curcumin	126-134	baculoviral IAP repeat containing 3	Homo sapiens	56-60
22997831-0	2012	[Effect of curcumin on synapse-related protein expression of APP/PS1 double transgenic mice].	Curcumin	11-19	presenilin 1	Mus musculus	65-68
22683883-6	2012	Treatment with curcumin significantly attenuated CCl(4)-induce liver injury, hepatic inflammation and reduced the levels of proinflammatory mediators (TNF-alpha, IL-6 and MCP-1).	Curcumin	15-23	C-C motif chemokine ligand 2	Rattus norvegicus	171-176
33014113-4	2020	Methods: To study the regulation effect of curcumin on ERCC1 expression and its effects on miRNAs, the L-OHP-resistant colorectal cancer cell line HCT116/L-OHP was established.	Curcumin	43-51	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	55-60
22739211-5	2012	Curcumin also blocked hypoxia-induced mRNA synthesis and secretion of VEGFA in GH3 cells and in all human pituitary adenoma cell cultures investigated (n=18).	Curcumin	0-8	vascular endothelial growth factor A	Rattus norvegicus	70-75
22997831-1	2012	OBJECTIVE: To observe the effect of curcumin on the expression of synapse-related proteins PSD-95 and Shank1 in APP/PS1 double transgenic mice.	Curcumin	36-44	presenilin 1	Mus musculus	116-119
22997831-5	2012	The expression of PSD-95 and Shank1-positive cells of hippocampus CA1 region significantly decreased in model mice compared with normal control group (P &lt; 0.01); while the curcumin intervention group showed recovery to some extend.	Curcumin	175-183	carbonic anhydrase 1	Mus musculus	66-69
22997831-7	2012	CONCLUSION: Curcumin can increase the expression of synapse-related proteins PSD95 and Shank1 in APP/PS1 double transgenic mice, improve structure and plasticity of synapse in APP/PS1 double transgenic mice and enhance their learning and memory abilities.	Curcumin	12-20	presenilin 1	Mus musculus	101-104
33014113-11	2020	Curcumin was found to inhibit ERCC1 through its ability to modulate miR-409-3p.	Curcumin	0-8	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	30-35
22997831-7	2012	CONCLUSION: Curcumin can increase the expression of synapse-related proteins PSD95 and Shank1 in APP/PS1 double transgenic mice, improve structure and plasticity of synapse in APP/PS1 double transgenic mice and enhance their learning and memory abilities.	Curcumin	12-20	presenilin 1	Mus musculus	180-183
22387197-8	2012	Curcumin treatment of leukemic cells also downregulates the expression of the inhibitor of apoptosis proteins (IAPs), phospho-Akt, c-Myc, and cyclin D1.	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	131-136
22709992-12	2012	In addition, Bax protein expression was significantly increased in PNCC in comparison with control and curcumin-treated groups (P&lt;0.001).	Curcumin	103-111	BCL2 associated X, apoptosis regulator	Rattus norvegicus	13-16
22410671-5	2012	Treatment with curcumin (2.5, 10, and 25 muM) decreased the expression of CCL2 mRNA and protein in a dose-dependent manner under treatment with LPS.	Curcumin	15-23	C-C motif chemokine ligand 2	Rattus norvegicus	74-78
33014113-12	2020	Conclusion: Curcumin can overcome L-OHP resistance in colorectal cancer cells through its effects on miR-409-3p mediated ERCC1 expression.	Curcumin	12-20	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	121-126
32335119-0	2020	Curcumin-human serum albumin nanoparticles decorated with PDL1 binding peptide for targeting PDL1-expressing breast cancer cells.	Curcumin	0-8	CD274 molecule	Homo sapiens	58-62
32335119-0	2020	Curcumin-human serum albumin nanoparticles decorated with PDL1 binding peptide for targeting PDL1-expressing breast cancer cells.	Curcumin	0-8	CD274 molecule	Homo sapiens	93-97
32335119-1	2020	In this research, programmed death ligand 1 (PDL1) binding peptide was used for targeted delivery of curcumin to high PDL1-expressing breast cancer cells.	Curcumin	101-109	CD274 molecule	Homo sapiens	18-43
22648616-4	2012	In addition, curcumin decreased the protein expression of scavenger receptor class A (SR-A) but increased that of ATP-binding cassette transporter (ABC) A1 and had no effect on the protein expression of CD36, class B receptor type I (SR-BI), or ATP-binding cassette transporter G1 (ABCG1).	Curcumin	13-21	ATP binding cassette subfamily G member 1	Mus musculus	282-287
32335119-1	2020	In this research, programmed death ligand 1 (PDL1) binding peptide was used for targeted delivery of curcumin to high PDL1-expressing breast cancer cells.	Curcumin	101-109	CD274 molecule	Homo sapiens	45-49
22648616-7	2012	Curcumin administration modulated the expression of SR-A, ABCA1, ABCG1, and SR-BI in aortas and retarded atherosclerosis in apoE-/- mice.	Curcumin	0-8	ATP binding cassette subfamily G member 1	Mus musculus	65-70
32335119-1	2020	In this research, programmed death ligand 1 (PDL1) binding peptide was used for targeted delivery of curcumin to high PDL1-expressing breast cancer cells.	Curcumin	101-109	CD274 molecule	Homo sapiens	118-122
32335119-2	2020	Human serum albumin-curcumin nanoparticles (HSA/Cur NP) were first prepared by desolvation method and then functionalized with PDL1 binding peptide.	Curcumin	20-28	CD274 molecule	Homo sapiens	127-131
32782494-0	2020	Curcumin affects ox-LDL-induced IL-6, TNF-alpha, MCP-1 secretion and cholesterol efflux in THP-1 cells by suppressing the TLR4/NF-kappaB/miR33a signaling pathway.	Curcumin	0-8	C-C motif chemokine ligand 2	Homo sapiens	49-54
22445643-4	2012	The results showed that curcumin attenuated ethanol-induced histopathological changes of the liver and ameliorated the evident release of cellular alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	Curcumin	24-32	glutamic pyruvic transaminase, soluble	Mus musculus	173-176
32782494-0	2020	Curcumin affects ox-LDL-induced IL-6, TNF-alpha, MCP-1 secretion and cholesterol efflux in THP-1 cells by suppressing the TLR4/NF-kappaB/miR33a signaling pathway.	Curcumin	0-8	toll like receptor 4	Homo sapiens	122-126
22445643-4	2012	The results showed that curcumin attenuated ethanol-induced histopathological changes of the liver and ameliorated the evident release of cellular alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	Curcumin	24-32	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	182-208
22445643-4	2012	The results showed that curcumin attenuated ethanol-induced histopathological changes of the liver and ameliorated the evident release of cellular alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	Curcumin	24-32	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	210-213
32782494-0	2020	Curcumin affects ox-LDL-induced IL-6, TNF-alpha, MCP-1 secretion and cholesterol efflux in THP-1 cells by suppressing the TLR4/NF-kappaB/miR33a signaling pathway.	Curcumin	0-8	microRNA 33a	Homo sapiens	137-143
32531667-3	2020	The aim of this study was to investigate whether curcumin could improve chronic kidney disease (CKD)-induced muscle atrophy and mitochondrial dysfunction by inhibiting glycogen synthase kinase-3beta (GSK-3beta) activity.	Curcumin	49-57	glycogen synthase kinase 3 beta	Mus musculus	168-198
22298641-8	2012	Furthermore, we found that curcumin-induced activation of MAPK pathways was related to inhibition of the serine/threonine protein phosphatases 2A (PP2A) and 5 (PP5).	Curcumin	27-35	protein phosphatase 2 phosphatase activator	Homo sapiens	147-158
22298641-9	2012	Overexpression of PP2A or PP5 partially prevented curcumin-induced activation of JNK and Erk1/2 phosphorylation as well as cell death.	Curcumin	50-58	protein phosphatase 2 phosphatase activator	Homo sapiens	18-22
22298641-10	2012	The results suggest that curcumin induction of ROS activates MAPKs, at least partially by inhibiting PP2A and PP5, thereby leading to p53-independent apoptosis in tumor cells.	Curcumin	25-33	protein phosphatase 2 phosphatase activator	Homo sapiens	101-105
32436614-0	2020	Curcumin alleviates OGD/R-induced PC12 cell damage via repressing CCL3 and inactivating TLR4/MyD88/MAPK/NF-kappaB to suppress inflammation and apoptosis.	Curcumin	0-8	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	93-98
21973306-0	2012	Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression.	Curcumin	51-59	mitogen-activated protein kinase kinase 1	Homo sapiens	92-96
32436614-11	2020	Moreover, high expression levels of TLR4, MyD88, p-NF-kappaB P65, p-P38 MAPK and p-IkappaBalpha in OGD/R model were inhibited by curcumin.	Curcumin	129-137	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	42-47
21973306-6	2012	Exposure of human NSCLC cell lines H1975 and H1650 to curcumin decreased MMC-elicited phosphorylated MKK1/2-ERK1/2 protein levels.	Curcumin	54-62	mitogen-activated protein kinase kinase 1	Homo sapiens	101-105
21973306-8	2012	Enhancement of ERK1/2 activation by constitutively active MKK1/2 (MKK1/2-CA) increased TP protein levels and cell viability in curcumin- and MMC-co-treated cells.	Curcumin	127-135	mitogen-activated protein kinase kinase 1	Homo sapiens	58-64
32436614-11	2020	Moreover, high expression levels of TLR4, MyD88, p-NF-kappaB P65, p-P38 MAPK and p-IkappaBalpha in OGD/R model were inhibited by curcumin.	Curcumin	129-137	NFKB inhibitor alpha	Rattus norvegicus	83-95
21973306-8	2012	Enhancement of ERK1/2 activation by constitutively active MKK1/2 (MKK1/2-CA) increased TP protein levels and cell viability in curcumin- and MMC-co-treated cells.	Curcumin	127-135	mitogen-activated protein kinase kinase 1	Homo sapiens	66-75
21973306-9	2012	In contrast, U0126, a MKK1/2 inhibitor, augmented the cytotoxic effect and the down-regulation of TP by curcumin and MMC.	Curcumin	104-112	mitogen-activated protein kinase kinase 1	Homo sapiens	22-28
32735850-0	2020	The neuroprotective effect of curcumin against Cd-induced neurotoxicity and hippocampal neurogenesis promotion through CREB-BDNF signaling pathway.	Curcumin	30-38	brain derived neurotrophic factor	Mus musculus	124-128
22783142-7	2012	Curcumin when co-supplemented with 2-PAMCl + atropine also significantly protected serum aspartate aminotransferase (AST) and restored brain AChE activity and 5-HT level in animals sub-chronically exposed to DDVP.	Curcumin	0-8	acetylcholinesterase	Rattus norvegicus	141-145
22030090-6	2012	Furthermore, curcumin treatment polarized MDSCs toward a M1-like phenotype with an increased expression of CCR7 and decreased expression of dectin 1 in vivo and in vitro.	Curcumin	13-21	C-type lectin domain containing 7A	Homo sapiens	140-148
21711158-6	2012	Curcumin induced a rapid decrease in mitochondrial membrane potential and the release of cytochrome c into the cytosol, followed by activation of caspase-9 and caspase-3.	Curcumin	0-8	caspase 9	Homo sapiens	146-155
22191431-4	2012	Our data show that epigallocatechin gallate (EGCG) and curcumin treatment reduce insulin receptor substrate-1 (IRS-1) Ser307 phosphorylation, and curcumin is more potent to increase Akt phosphorylation in TPA induction.	Curcumin	55-63	insulin receptor substrate 1	Mus musculus	81-109
32662804-0	2020	Non-invasive optical imaging of retinal Abeta plaques using curcumin loaded polymeric micelles in APPswe/PS1DeltaE9 transgenic mice for the diagnosis of Alzheimer"s disease.	Curcumin	60-68	amyloid beta (A4) precursor protein	Mus musculus	40-45
22191431-4	2012	Our data show that epigallocatechin gallate (EGCG) and curcumin treatment reduce insulin receptor substrate-1 (IRS-1) Ser307 phosphorylation, and curcumin is more potent to increase Akt phosphorylation in TPA induction.	Curcumin	55-63	insulin receptor substrate 1	Mus musculus	111-116
22191431-6	2012	With a longer incubation with palmitate, IRS-1 exhibited a dramatic depletion, and treatment with EGCG, ECG, and curcumin could reverse IRS-1 expression, Akt phosphorylation, and MAPK signaling cascade activation and improve glucose uptake in C2C12 skeletal muscle cells, especially ECG and curcumin.	Curcumin	113-121	insulin receptor substrate 1	Mus musculus	136-141
32662804-6	2020	One promising polyphenol compound that has found application in this area is curcumin due to its natural binding affinity to Abeta fibrils and oligomers while giving out a strong fluorescence signal.	Curcumin	77-85	amyloid beta (A4) precursor protein	Mus musculus	125-130
32662804-8	2020	To address these limitations, we herein report the development of anionic and water-soluble DSPE-PEG2000 curcumin polymeric micelles (also referred to as curcumin micelles) that can label both brain and retinal Abeta plaques ex vivo.	Curcumin	105-113	amyloid beta (A4) precursor protein	Mus musculus	211-216
32662804-8	2020	To address these limitations, we herein report the development of anionic and water-soluble DSPE-PEG2000 curcumin polymeric micelles (also referred to as curcumin micelles) that can label both brain and retinal Abeta plaques ex vivo.	Curcumin	154-162	amyloid beta (A4) precursor protein	Mus musculus	211-216
32618472-10	2020	A strong interaction of curcumin is obsereved with p53, uPA, and PAI-I proteins.	Curcumin	24-32	transformation related protein 53, pseudogene	Mus musculus	51-54
22512082-6	2012	In addition, curcumin significantly (P &lt; 0.01 at 10 microM) enhanced the cellular accumulation of rhodamine-123 in MCF-7/ADR cells overexpressing P-gp in a concentration-dependent manner.	Curcumin	13-21	phosphoglycolate phosphatase	Homo sapiens	149-153
22273506-6	2012	The histone acetyltransferase (HAT) inhibitor curcumin was able to abrogate microgravity-induced p21 mRNA expression, whereas expression was enhanced by a histone deacetylase (HDAC) inhibitor.	Curcumin	46-54	H3 histone pseudogene 16	Homo sapiens	97-100
32618472-10	2020	A strong interaction of curcumin is obsereved with p53, uPA, and PAI-I proteins.	Curcumin	24-32	plasminogen activator, urokinase	Mus musculus	56-59
32618472-12	2020	Therapeutic efficacy of curcumin exhibited a protective role against the progression of pulmonary fibrosis, which promises the potent therapeutic modality to target IL-17A mediated p53-fibrinolytic system during pulmonary fibrosis.	Curcumin	24-32	transformation related protein 53, pseudogene	Mus musculus	181-184
26069496-7	2012	The cytotoxicity, reactive oxygen species, and cell uptake were found to be increased considerably with Tf-C-SLN compared with curcumin-solubilized surfactant solution, and curcumin-loaded SLN (C-SLN) suggesting the targeting effect.	Curcumin	173-181	sarcolipin	Homo sapiens	189-192
32757994-0	2020	Curcumin Suppresses Cell Proliferation, Migration, and Invasion Through Modulating miR-21-5p/SOX6 Axis in Hepatocellular Carcinoma.	Curcumin	0-8	microRNA 21	Homo sapiens	83-89
26069496-7	2012	The cytotoxicity, reactive oxygen species, and cell uptake were found to be increased considerably with Tf-C-SLN compared with curcumin-solubilized surfactant solution, and curcumin-loaded SLN (C-SLN) suggesting the targeting effect.	Curcumin	173-181	sarcolipin	Homo sapiens	189-192
26069496-10	2012	The in vitro observations of our investigation are very compelling and concrete to advocate the potential of Tf-C-SLN in enhancing the anticancer effect of curcumin against neuroblastoma in vivo and possible clinical applications.	Curcumin	156-164	sarcolipin	Homo sapiens	114-117
32535538-4	2020	Immunofluorescence analysis reveals that the natural spice curcumin blocks the expressions of COX-2, NF-kappaB-p65, fibronectin (FBN), and expresses P-AMPKalpha in vivo.	Curcumin	59-67	fibronectin 1	Mus musculus	116-127
32535538-4	2020	Immunofluorescence analysis reveals that the natural spice curcumin blocks the expressions of COX-2, NF-kappaB-p65, fibronectin (FBN), and expresses P-AMPKalpha in vivo.	Curcumin	59-67	fibronectin 1	Mus musculus	129-132
22211690-0	2012	Curcumin-glucoside, a novel synthetic derivative of curcumin, inhibits alpha-synuclein oligomer formation: relevance to Parkinson"s disease.	Curcumin	52-60	synuclein alpha	Homo sapiens	71-86
32535538-6	2020	mRNA expressions showed reduced expressions of PDGFA, PDGFB, CTGF, IGF1, NFkappaB1, NFkappaB2, MMP-3, MMP-9, and MMP-14 on curcumin treatment.	Curcumin	123-131	platelet derived growth factor, B polypeptide	Mus musculus	54-59
32535538-6	2020	mRNA expressions showed reduced expressions of PDGFA, PDGFB, CTGF, IGF1, NFkappaB1, NFkappaB2, MMP-3, MMP-9, and MMP-14 on curcumin treatment.	Curcumin	123-131	matrix metallopeptidase 3	Mus musculus	95-100
22155627-10	2012	We also found that the mice treated with dendrosomal curcumin, showed a significant increase in splenocyte proliferation and IFN-gamma production as well as a significant decrease in IL-4 production.	Curcumin	53-61	interleukin 4	Mus musculus	183-187
32626956-0	2020	miR-192-5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c-Myc and inactivating the Wnt/beta-catenin signaling pathway.	Curcumin	52-60	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	132-137
32626956-0	2020	miR-192-5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c-Myc and inactivating the Wnt/beta-catenin signaling pathway.	Curcumin	52-60	catenin beta 1	Homo sapiens	163-175
32626956-9	2020	Curcumin treatment inhibited NSCLC cell proliferation, migration, invasion and viability in a dose-dependent manner, in addition to promoting a dose-dependent increase in the expression levels of miR-192-5p and a reduction in c-Myc expression levels.	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	226-231
22927762-8	2012	Most importantly, curcumin-loaded CSO-SA micelles were effective for inhibiting subpopulations of CD44(+)/CD24(+) cells (putative colorectal cancer stem cell markers) both in vitro and in vivo.	Curcumin	18-26	CD24a antigen	Mus musculus	106-110
22172229-8	2012	Curcumin also increased the serum levels of adiponectin while conversely decreasing the serum levels of leptin and the weights of fat.	Curcumin	0-8	adiponectin, C1Q and collagen domain containing	Mus musculus	44-55
32803504-0	2020	Ameliorative effect of curcumin on altered expression of CACNA1A and GABRD in the pathogenesis of FeCl3-induced epilepsy.	Curcumin	23-31	gamma-aminobutyric acid type A receptor subunit delta	Rattus norvegicus	69-74
32803504-13	2020	Results also demonstrated that curcumin administration ameliorated epilepsy-associated change in expression of both CACNA1A and GABRD proteins.	Curcumin	31-39	gamma-aminobutyric acid type A receptor subunit delta	Rattus norvegicus	128-133
32430842-9	2020	Our data also revealed that CM-NP could significantly reduce the invasiveness of GSCs compared with CM, possibly via MCP-1-mediated pathways.	Curcumin	28-30	C-C motif chemokine ligand 2	Homo sapiens	117-122
23185512-4	2012	CCL2-mediated VCAM-1 expression was attenuated by CCR2 inhibitor (RS102895), PKCdelta inhibitor (rottlerin), p38MAPK inhibitor (SB203580), and AP-1 inhibitors (curcumin and tanshinone IIA).	Curcumin	160-168	C-C motif chemokine ligand 2	Homo sapiens	0-4
22745783-10	2012	Likewise, curcumin prevented the increase of SBP, CRP, TNF alpha, D-dimer and PAI-1.	Curcumin	10-18	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	78-83
22470431-8	2012	We document that curcumin can inhibit the expression of MRP-1 and LRP gene/protein in a concentration dependent manner in Y79 cells.	Curcumin	17-25	MDM4 regulator of p53	Homo sapiens	56-61
22410671-8	2012	These data suggest that the anti-neuroinflammatory effect of curcumin relates to the downregulation of CCL2 expression through the JNK pathway in astrocytoma cells, which indicates a possible benefit from the use of curcumin in the treatment of neuroinflammation-associated disorders.	Curcumin	61-69	C-C motif chemokine ligand 2	Rattus norvegicus	103-107
32893562-5	2020	HE staining showed that curcumin could improve the pathological changes of pancreas and reduce the pathological score of pancreas, while ELISA results showed that curcumin could decrease the levels of amylase, lipase and Bax in peripheral serum and increase the concentration of Bcl-2.	Curcumin	163-171	lipase G, endothelial type	Rattus norvegicus	210-216
22410671-8	2012	These data suggest that the anti-neuroinflammatory effect of curcumin relates to the downregulation of CCL2 expression through the JNK pathway in astrocytoma cells, which indicates a possible benefit from the use of curcumin in the treatment of neuroinflammation-associated disorders.	Curcumin	61-69	mitogen-activated protein kinase 8	Rattus norvegicus	131-134
22410671-8	2012	These data suggest that the anti-neuroinflammatory effect of curcumin relates to the downregulation of CCL2 expression through the JNK pathway in astrocytoma cells, which indicates a possible benefit from the use of curcumin in the treatment of neuroinflammation-associated disorders.	Curcumin	216-224	C-C motif chemokine ligand 2	Rattus norvegicus	103-107
22348084-0	2012	Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila.	Curcumin	0-8	beta amyloid protein precursor-like	Drosophila melanogaster	18-24
22363450-8	2012	Furthermore, curcumin treatment led to reduced Notch-1 activation, expression of Jagged-1 and its downstream target Hes-1.	Curcumin	13-21	jagged canonical Notch ligand 1	Homo sapiens	81-89
32893562-5	2020	HE staining showed that curcumin could improve the pathological changes of pancreas and reduce the pathological score of pancreas, while ELISA results showed that curcumin could decrease the levels of amylase, lipase and Bax in peripheral serum and increase the concentration of Bcl-2.	Curcumin	163-171	BCL2 associated X, apoptosis regulator	Rattus norvegicus	221-224
22363450-11	2012	Finally, curcumin treatment down-regulate the expressions of Notch-1 specific microRNAs miR-21 and miR-34a, and upregulated tumor suppressor let-7a miRNA.	Curcumin	9-17	microRNA 21	Homo sapiens	88-94
22594559-0	2012	Sphingosine kinase-1 inhibition sensitizes curcumin-induced growth inhibition and apoptosis in ovarian cancer cells.	Curcumin	43-51	sphingosine kinase 1	Homo sapiens	0-20
22594559-2	2012	Using in vitro approaches, we analyzed the impact of sphingosine kinase-1 (SphK-1) inhibition on ceramide production, and evaluated SphK1 inhibitor II (SKI-II) as a potential curcumin chemo-sensitizer in ovarian cancer cells.	Curcumin	175-183	sphingosine kinase 1	Homo sapiens	132-137
22860163-0	2011	"Clicked" sugar-curcumin conjugate: modulator of amyloid-beta and tau peptide aggregation at ultralow concentrations.	Curcumin	16-24	microtubule associated protein tau	Homo sapiens	66-69
32576716-7	2020	In xenograft mouse model experiments, curcumin effectively reduced tumour size whereas PRP4 conferred resistance to curcumin, which was evident from increasing tumour size, while PRP8 failed to regulate the curcumin action.	Curcumin	116-124	pre-mRNA processing factor 4B	Mus musculus	87-91
22860163-1	2011	The synthesis of a water/plasma soluble, noncytotoxic, "clicked" sugar-derivative of curcumin with amplified bioefficacy in modulating amyloid-beta and tau peptide aggregation is presented.	Curcumin	85-93	microtubule associated protein tau	Homo sapiens	152-155
22860163-2	2011	Curcumin inhibits amyloid-beta and tau peptide aggregation at micromolar concentrations; the sugar-curcumin conjugate inhibits Abeta and tau peptide aggregation at concentrations as low as 8 nM and 0.1 nM, respectively.	Curcumin	0-8	microtubule associated protein tau	Homo sapiens	35-38
22860163-2	2011	Curcumin inhibits amyloid-beta and tau peptide aggregation at micromolar concentrations; the sugar-curcumin conjugate inhibits Abeta and tau peptide aggregation at concentrations as low as 8 nM and 0.1 nM, respectively.	Curcumin	99-107	microtubule associated protein tau	Homo sapiens	137-140
21932293-0	2011	The effect of curcumin in the ectonucleotidases and acetylcholinesterase activities in synaptosomes from the cerebral cortex of cigarette smoke-exposed rats.	Curcumin	14-22	acetylcholinesterase	Rattus norvegicus	52-72
21932293-4	2011	Curcumin prevented the increased NTPDase, 5"-nucleotidase and AChE activities caused by smoke exposure.	Curcumin	0-8	acetylcholinesterase	Rattus norvegicus	62-66
22507634-0	2012	Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of alpha1-antitrypsin in lung cancer.	Curcumin	0-8	elastase, neutrophil expressed	Mus musculus	49-68
22507634-6	2012	We found that curcumin counteracted the decrease of alpha1-antitrypsin induced by neutrophil elastase by inducing the promoter activity of alpha1-antitrypsin and promoting its expression in A549 cells.	Curcumin	14-22	elastase, neutrophil expressed	Mus musculus	82-101
22507634-7	2012	The inhibition of neutrophil elastase-induced proliferation by curcumin was dependent on the PI3K/Akt pathway.	Curcumin	63-71	elastase, neutrophil expressed	Mus musculus	18-37
22579739-0	2012	Curcumin protects against cigarette smoke-induced cognitive impairment and increased acetylcholinesterase activity in rats.	Curcumin	0-8	acetylcholinesterase	Rattus norvegicus	85-105
22579915-0	2012	beta2-adrenoceptor and insulin receptor expression in the skeletal muscle of streptozotocin induced diabetic rats: antagonism by vitamin D3 and curcumin.	Curcumin	144-152	adrenoceptor beta 2	Rattus norvegicus	0-18
22101335-0	2011	Curcumin induces Apaf-1-dependent, p21-mediated caspase activation and apoptosis.	Curcumin	0-8	H3 histone pseudogene 16	Homo sapiens	35-38
22101335-7	2011	Cytochrome c release from mitochondria to the cytosol in curcumin-treated cells was associated with upregulation of proapoptotic proteins such as Bax, Bak, Bid, and Bim.	Curcumin	57-65	BCL2 like 11	Homo sapiens	165-168
22449710-0	2012	HSP27 modulates survival signaling networks in cells treated with curcumin and TRAIL.	Curcumin	66-74	heat shock protein family B (small) member 1	Homo sapiens	0-5
22101335-8	2011	Crosslinking experiments demonstrated Bax oligomerization during curcumin-induced apoptosis, suggesting that induced expression of Bax, Bid, and Bim causes Bax-channel formation on the mitochondrial membrane.	Curcumin	65-73	BCL2 like 11	Homo sapiens	145-148
22101335-10	2011	Importantly, p21-deficiency resulted in reduced expression of Apaf-1 during curcumin treatment, indicating a requirement of p21 in Apaf-1 dependent caspase activation and apoptosis.	Curcumin	76-84	H3 histone pseudogene 16	Homo sapiens	13-16
32576716-7	2020	In xenograft mouse model experiments, curcumin effectively reduced tumour size whereas PRP4 conferred resistance to curcumin, which was evident from increasing tumour size, while PRP8 failed to regulate the curcumin action.	Curcumin	116-124	pre-mRNA processing factor 4B	Mus musculus	87-91
32676763-7	2020	The sensitivity of the described method in terms of detection limits was 0.3 and 0.1 mug mL-1 for curcumin and nanocurcumin, respectively.	Curcumin	98-106	L1 cell adhesion molecule	Mus musculus	89-93
22101335-11	2011	Together, our findings demonstrate that Apaf-1, Bax, and p21 as novel potential targets for curcumin or curcumin-based anticancer agents.	Curcumin	92-100	H3 histone pseudogene 16	Homo sapiens	57-60
22101335-11	2011	Together, our findings demonstrate that Apaf-1, Bax, and p21 as novel potential targets for curcumin or curcumin-based anticancer agents.	Curcumin	104-112	H3 histone pseudogene 16	Homo sapiens	57-60
21695461-5	2011	Enzyme-linked immunosorbent assay (ELISA) showed that curcumin suppressed proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and interleukin (IL)-4 production in Con A-injected mice.	Curcumin	54-62	interleukin 4	Mus musculus	171-189
22392462-0	2012	Curcumin ameliorates hydrogen peroxide-induced epithelial barrier disruption by upregulating heme oxygenase-1 expression in human intestinal epithelial cells.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	93-109
22392462-2	2012	Heme oxygenase-1 (HO-1), which can be induced by curcumin (Cur), provides protection against various forms of oxidative stress.	Curcumin	49-57	heme oxygenase 1	Homo sapiens	0-16
22392462-2	2012	Heme oxygenase-1 (HO-1), which can be induced by curcumin (Cur), provides protection against various forms of oxidative stress.	Curcumin	49-57	heme oxygenase 1	Homo sapiens	18-22
23060694-10	2012	In contrast, curcumin decreased adipocyte differentiation and inhibited adipocyte-specific mRNA expression of PPARgamma2 and C/EBPalpha when rMSCs were cultured in adipogenic medium.	Curcumin	13-21	CCAAT/enhancer binding protein alpha	Rattus norvegicus	125-135
32733195-2	2020	Our previous study suggested that acute treatment with a novel curcumin derivative J147 exhibited antidepressant-like effects by increasing brain derived neurotrophic factor (BDNF) level in the hippocampus of mice.	Curcumin	63-71	brain derived neurotrophic factor	Mus musculus	140-173
22580738-0	2012	Enhancement of cellular uptake and cytotoxicity of curcumin-loaded PLGA nanoparticles by conjugation with anti-P-glycoprotein in drug resistance cancer cells.	Curcumin	51-59	phosphoglycolate phosphatase	Homo sapiens	106-125
21839772-5	2011	Simultaneous treatment with arsenic and curcumin (100mg/kg body weight, p.o., 28 days) increased learning and memory performance associated with increased binding of (3)H-QNB in hippocampus (54%), frontal cortex (25%) and activity of acetylcholinesterase in hippocampus (41%) and frontal cortex (29%) as compared to arsenic treated rats.	Curcumin	40-48	acetylcholinesterase	Rattus norvegicus	234-254
22126332-7	2011	HFL-1 cells were used to investigate the effects of curcumin and cathepsin inhibition on cell proliferation, migration, apoptosis, and the expression of cathepsins K and L and TGF-beta1.	Curcumin	52-60	complement factor H related 1	Homo sapiens	0-5
22126332-11	2011	Here, cathepsin K and L expression increased 190% and 240%, respectively, in the presence of curcumin and the expression of TGF-beta1 decreased by 34%.	Curcumin	93-101	cathepsin K	Homo sapiens	6-17
32733195-2	2020	Our previous study suggested that acute treatment with a novel curcumin derivative J147 exhibited antidepressant-like effects by increasing brain derived neurotrophic factor (BDNF) level in the hippocampus of mice.	Curcumin	63-71	brain derived neurotrophic factor	Mus musculus	175-179
22126332-14	2011	CONCLUSION: This study demonstrates that curcumin increases the expression of cathepsins K and L in lung which an effect on lung fibroblast cell behavior such as proliferation, migration and apoptosis rates and on the expression of TGF-beta1 in mouse lung and HFL-1 cells.	Curcumin	41-49	complement factor H related 1	Homo sapiens	260-265
32772715-0	2020	Synergistic antibacterial and anti-biofilm activity of nisin like bacteriocin with curcumin and cinnamaldehyde against ESBL and MBL producing clinical strains.	Curcumin	83-91	colicin E1 protein	Escherichia coli	66-77
21968503-15	2011	As both oxidative stress and PAI-1 production were reduced by simvastatin and curcumin, modulation of oxidative stress and PAI-1 production are attractive targets for pharmacotherapy of cardiovascular disorders associated with an increased PAI-1 including type 2 diabetes and its associated consequences including accelerated coronary artery disease and an increased fibrosis that may exacerbate adverse left ventricular remodeling after myocardial infarction.	Curcumin	78-86	serpin family E member 1	Homo sapiens	123-128
21968503-15	2011	As both oxidative stress and PAI-1 production were reduced by simvastatin and curcumin, modulation of oxidative stress and PAI-1 production are attractive targets for pharmacotherapy of cardiovascular disorders associated with an increased PAI-1 including type 2 diabetes and its associated consequences including accelerated coronary artery disease and an increased fibrosis that may exacerbate adverse left ventricular remodeling after myocardial infarction.	Curcumin	78-86	serpin family E member 1	Homo sapiens	123-128
21594647-8	2011	Curcumin activated the stress-activated p38 kinase, caspases 9 and 3, caused elevated levels of proapoptotic proteins Bax, stimulated PARP cleavage, and apoptosis.	Curcumin	0-8	caspase 9	Homo sapiens	52-68
22076061-1	2012	Molecular docking and molecular dynamics (MD) simulations are used to investigate the interactions of curcumin analogues (CAs) with human cytochrome P450 2 C9 (CYP2C9 or 2 C9) and the conformations of their binding sites.	Curcumin	102-110	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	138-158
22076061-1	2012	Molecular docking and molecular dynamics (MD) simulations are used to investigate the interactions of curcumin analogues (CAs) with human cytochrome P450 2 C9 (CYP2C9 or 2 C9) and the conformations of their binding sites.	Curcumin	102-110	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	160-166
22822540-7	2012	BCRP was found to participate in curcumin transport, but the Organic Anion Transporting Polypeptide (OATP) did not.	Curcumin	33-41	BCR pseudogene 1	Homo sapiens	0-4
21936051-8	2011	ELISA and transient gene expression assays indicated that curcumin blocked the activation of L-mimosine or DMOG treatment on PSA expression.	Curcumin	58-66	kallikrein related peptidase 3	Homo sapiens	125-128
32772715-4	2020	Bacteriocin-GAM217 when combined with curcumin and cinnamaldehyde, synergistically enhanced antibacterial activity against planktonic and biofilm cultures of Staphylococcus epidermidis and Escherichia coli.	Curcumin	38-46	colicin E1 protein	Escherichia coli	0-11
21936051-9	2011	CONCLUSIONS: These results indicate that curcumin blocked the enhanced effect of PSA expression by L-mimosine and DMOG that induce hypoxia condition.	Curcumin	41-49	kallikrein related peptidase 3	Homo sapiens	81-84
22446486-6	2012	Conversely, prevention of histone acetylation by the histone acetyltransferase inhibitor curcumin diminished PU.1 expression after IL-9-inducing stimulation.	Curcumin	89-97	Spi-1 proto-oncogene	Homo sapiens	109-113
32135258-6	2020	CTAB-modified-NCCS, -pectin-15 and Alg-5 were found to be the best supports as they released appreciable amount of curcumin for a longer time.	Curcumin	115-123	ALG5 dolichyl-phosphate beta-glucosyltransferase	Homo sapiens	35-40
22466958-0	2012	The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway.	Curcumin	15-23	signal transducer and activator of transcription 3	Rattus norvegicus	109-114
22027502-1	2012	In the present study, the antioxidative and anticlastogenic effects of curcumin and piperine separately and in combination have been investigated against benzo(a)pyrene (BaP)-mediated toxicity in mice.	Curcumin	71-79	prohibitin 2	Mus musculus	170-173
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	19-27	prohibitin 2	Mus musculus	95-98
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	19-27	hematopoietic prostaglandin D synthase	Mus musculus	249-274
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	19-27	hematopoietic prostaglandin D synthase	Mus musculus	276-279
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	19-27	prohibitin 2	Mus musculus	302-305
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	32-40	prohibitin 2	Mus musculus	95-98
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	32-40	hematopoietic prostaglandin D synthase	Mus musculus	249-274
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	32-40	hematopoietic prostaglandin D synthase	Mus musculus	276-279
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	32-40	prohibitin 2	Mus musculus	302-305
22027502-5	2012	The effect of curcumin plus piperine is more pronounced as compared to curcumin in attenuating BaP-induced oxidative insult and clastogenicity.	Curcumin	14-22	prohibitin 2	Mus musculus	95-98
22027502-5	2012	The effect of curcumin plus piperine is more pronounced as compared to curcumin in attenuating BaP-induced oxidative insult and clastogenicity.	Curcumin	71-79	prohibitin 2	Mus musculus	95-98
22812232-0	2012	[Study on curcumin-induced apoptosis in ovarian cancer resistant cell lines COC1/DDP].	Curcumin	10-18	translocase of inner mitochondrial membrane 8A	Homo sapiens	81-84
22812232-1	2012	OBJECTIVE: To investigate the effect and possible mechanism of curcumin to induce apoptosis in ovarian cancer resistant cell lines COC1/DDP.	Curcumin	63-71	translocase of inner mitochondrial membrane 8A	Homo sapiens	131-139
22812232-5	2012	RESULTS: After the treatment of different concentration of curcumin for 48 hours, the growth inhibition rates and the apoptotic rate of COC1/DDP cells were gradually increased accordingly with increasing curcumin concentration.	Curcumin	59-67	translocase of inner mitochondrial membrane 8A	Homo sapiens	141-144
22812232-5	2012	RESULTS: After the treatment of different concentration of curcumin for 48 hours, the growth inhibition rates and the apoptotic rate of COC1/DDP cells were gradually increased accordingly with increasing curcumin concentration.	Curcumin	204-212	translocase of inner mitochondrial membrane 8A	Homo sapiens	141-144
22812232-7	2012	The expression of PI3KCA mRNA of COC1/DDP cells treated with curcumin combined DDP was much lower than that treated only with DDP (P &lt; 0.05).	Curcumin	61-69	translocase of inner mitochondrial membrane 8A	Homo sapiens	38-41
22812232-7	2012	The expression of PI3KCA mRNA of COC1/DDP cells treated with curcumin combined DDP was much lower than that treated only with DDP (P &lt; 0.05).	Curcumin	61-69	translocase of inner mitochondrial membrane 8A	Homo sapiens	79-82
22812232-7	2012	The expression of PI3KCA mRNA of COC1/DDP cells treated with curcumin combined DDP was much lower than that treated only with DDP (P &lt; 0.05).	Curcumin	61-69	translocase of inner mitochondrial membrane 8A	Homo sapiens	79-82
22812232-8	2012	CONCLUSION: Curcumin can increase the apoptotic rate of COC1/DDP cells, so has synergistic effect on with chemotherapy drugs on the induction of cell apoptosis.	Curcumin	12-20	translocase of inner mitochondrial membrane 8A	Homo sapiens	61-64
22445643-4	2012	The results showed that curcumin attenuated ethanol-induced histopathological changes of the liver and ameliorated the evident release of cellular alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	Curcumin	24-32	glutamic pyruvic transaminase, soluble	Mus musculus	147-171
21614553-0	2012	A novel synthetic mono-carbonyl analogue of curcumin, A13, exhibits anti-inflammatory effects in vivo by inhibition of inflammatory mediators.	Curcumin	44-52	UDP glycosyltransferase 1 family, polypeptide A10	Mus musculus	54-57
21614553-3	2012	Our previous study synthesized and evaluated a hydrosoluble mono-carbonyl analogue of curcumin, (2E,5E)-2,5-bis(4-(3-(dimethylamino)-propoxy)benzylidene)cyclopentanone (A13).	Curcumin	86-94	UDP glycosyltransferase 1 family, polypeptide A10	Mus musculus	169-172
21801469-5	2012	A significant and dose-dependent decrease in leptin was observed after incubating the cells with SB and curcumin for 12 and 24 h, whereas SS decreased leptin concentrations after 24 h of treatment.	Curcumin	104-112	leptin	Mus musculus	45-51
21801469-8	2012	The food additives SS, SB and curcumin affect the leptin release after co-incubation with LPS from cultured adipocytes in a dose- and time-dependent manner.	Curcumin	30-38	leptin	Mus musculus	50-56
25774181-2	2012	Graded concentration and time course experiments demonstrate that curcumin significantly upregulates phosphatidylinositol 3-kinase (PI3K), Akt, nuclear factor E2-related factor-2 (Nrf2), heme oxygenase 1 and ferritin expression, and that it significantly downregulates heme oxygenase 2, reactive oxygen species and amyloid-beta 40/42 expression.	Curcumin	66-74	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	101-130
25774181-2	2012	Graded concentration and time course experiments demonstrate that curcumin significantly upregulates phosphatidylinositol 3-kinase (PI3K), Akt, nuclear factor E2-related factor-2 (Nrf2), heme oxygenase 1 and ferritin expression, and that it significantly downregulates heme oxygenase 2, reactive oxygen species and amyloid-beta 40/42 expression.	Curcumin	66-74	heme oxygenase 1	Homo sapiens	187-203
25774181-4	2012	The results indicate that the cytoprotection conferred by curcumin on APPswe transfected SH-SY5Y cells is mediated by its ability to regulate the balance between heme oxygenase 1 and 2 via the PI3K/Akt/Nrf2 intracellular signaling pathway.	Curcumin	58-66	heme oxygenase 1	Homo sapiens	162-184
22144489-8	2012	Dietary administration of 6% pectin or 4% curcumin in C. rodentium-infected mice also inhibited NF-kappaB activity and blocked CD3, F4/80, IL-1alpha/beta, G-CSF/MCP-1/KC, and MPO activity in the CLP while not affecting NF-kappaB activity in the crypts.	Curcumin	42-50	interleukin 1 alpha	Mus musculus	139-148
21627988-7	2011	In addition, the use of curcumin, an anti-cancer drug, or GRGDSP, the blocking peptide along with exogenous HABP1, inhibited such NFkappaB-dependent pathway, confirming that HABP1-induced cell migration is alpha(v)beta(3) integrin-mediated and downstream signaling by NFkappaB.	Curcumin	24-32	complement component 1, q subcomponent binding protein	Mus musculus	174-179
21627988-9	2011	The treatment of curcumin, the anticancer drug along with HABP1, inhibited the migration, expression of MT1-MMP and activation of MMP-2 and finally tumor growth supports the involvement of HABP1 in tumor formation.	Curcumin	17-25	complement component 1, q subcomponent binding protein	Mus musculus	58-63
21627988-9	2011	The treatment of curcumin, the anticancer drug along with HABP1, inhibited the migration, expression of MT1-MMP and activation of MMP-2 and finally tumor growth supports the involvement of HABP1 in tumor formation.	Curcumin	17-25	complement component 1, q subcomponent binding protein	Mus musculus	189-194
21821700-0	2011	Curcumin treatment suppresses IKKbeta kinase activity of salivary cells of patients with head and neck cancer: a pilot study.	Curcumin	0-8	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	30-37
21821700-1	2011	PURPOSE: To determine whether curcumin would inhibit IkappaB kinase beta (IKKbeta) kinase activity and suppress expression of proinflammatory cytokines in head and neck squamous cell carcinoma cancer (HNSCC) patients.	Curcumin	30-38	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	53-72
21821700-1	2011	PURPOSE: To determine whether curcumin would inhibit IkappaB kinase beta (IKKbeta) kinase activity and suppress expression of proinflammatory cytokines in head and neck squamous cell carcinoma cancer (HNSCC) patients.	Curcumin	30-38	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	74-81
21821700-6	2011	RESULTS: Curcumin treatment led to a reduction in IKKbeta kinase activity in the salivary cells of HNSCC patients (P &lt; 0.05).	Curcumin	9-17	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	50-57
21821700-7	2011	Treatment of UM-SCC1 cells with curcumin as well as with post-curcumin salivary supernatant showed a reduction of IKKbeta kinase activity.	Curcumin	32-40	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	114-121
21821700-7	2011	Treatment of UM-SCC1 cells with curcumin as well as with post-curcumin salivary supernatant showed a reduction of IKKbeta kinase activity.	Curcumin	62-70	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	114-121
21821700-13	2011	CONCLUSIONS: Curcumin inhibited IKKbeta kinase activity in the saliva of HNSCC patients, and this inhibition correlated with reduced expression of a number of cytokines.	Curcumin	13-21	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	32-39
21821700-14	2011	IKKbeta kinase could be a useful biomarker for detecting the effect of curcumin in head and neck cancer.	Curcumin	71-79	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	0-7
21810436-5	2011	Exposure of two human non-small lung cancer (NSCLC) cell lines (A549 and H1975) to curcumin could suppress MMC-induced MKK1/2-ERK1/2 signal activation and Rad51 protein expression.	Curcumin	83-91	mitogen-activated protein kinase kinase 1	Homo sapiens	119-123
21810436-6	2011	Enhancement of ERK1/2 activation by constitutively active MKK1/2 (MKK1/2-CA) increased Rad51 protein levels in curcumin and MMC co-treated human lung cells.	Curcumin	111-119	mitogen-activated protein kinase kinase 1	Homo sapiens	58-64
21810436-6	2011	Enhancement of ERK1/2 activation by constitutively active MKK1/2 (MKK1/2-CA) increased Rad51 protein levels in curcumin and MMC co-treated human lung cells.	Curcumin	111-119	mitogen-activated protein kinase kinase 1	Homo sapiens	66-75
21810436-7	2011	Moreover, the synergistic cytotoxic effect induced by curcumin combined with MMC was decreased by MKK1-CA-mediated enhancement of ERK1/2 activation by a significant degree.	Curcumin	54-62	mitogen-activated protein kinase kinase 1	Homo sapiens	98-102
21810436-8	2011	In contrast, MKK1/2 inhibitor, U0126 was shown to augment the cytotoxicity of curcumin and MMC through downregulation of ERK1/2 activation and Rad51 expression.	Curcumin	78-86	mitogen-activated protein kinase kinase 1	Homo sapiens	13-19
21689105-4	2011	Pre-treatment with curcumin reversed this effect on mRNA for the 5-HT(1A) and 5-HT(4) receptors, but not for the 5-HT(2A) receptor.	Curcumin	19-27	5-hydroxytryptamine receptor 1A	Homo sapiens	65-72
21689105-6	2011	This observed effect of curcumin was partially blocked by either 5-HT(1A) receptor antagonist p-MPPI or 5-HT(4) receptor antagonist RS 39604 alone; whereas, the simultaneous application of both antagonists completely reversed the effect.	Curcumin	24-32	5-hydroxytryptamine receptor 1A	Homo sapiens	65-82
21906467-0	2011	[Effect of curcumin on IL-17-induced nitric oxide production and expression of iNOS in human keratinocytes].	Curcumin	11-19	inositol-3-phosphate synthase 1	Homo sapiens	79-83
21906467-5	2011	Curcumin decreased IL-17 induced NO production and the iNOS expression at mRNA (P&lt;0.01) and protein (P&lt;0.01) levels significantly.	Curcumin	0-8	inositol-3-phosphate synthase 1	Homo sapiens	55-59
21906467-6	2011	CONCLUSION: Curcumin down-regulates IL-17-induced NO secretions and iNOS expression in HaCaT cells, thus provides a theoretical basis for the treatment of inflammatory diseases of skin related to keratinocytes.	Curcumin	12-20	inositol-3-phosphate synthase 1	Homo sapiens	68-72
21617861-5	2011	The results indicated that curcumin-induced G2/M phase arrest was associated with a marked decrease in the protein expression of cyclin A, cyclin B and cyclin-dependent kinase 1 (Cdk1).	Curcumin	27-35	cyclin dependent kinase 1	Homo sapiens	152-177
21617861-5	2011	The results indicated that curcumin-induced G2/M phase arrest was associated with a marked decrease in the protein expression of cyclin A, cyclin B and cyclin-dependent kinase 1 (Cdk1).	Curcumin	27-35	cyclin dependent kinase 1	Homo sapiens	179-183
21617861-6	2011	Curcumin-induced apoptosis was accompanied with upregulation of the protein expression of Bax and downregulation of the protein levels of Bcl-2, resulting in dysfunction of mitochondria and subsequently led to cytochrome c release and sequential activation of caspase-9 and caspase-3 in NPC-TW 076 cells in a time-dependent manner.	Curcumin	0-8	caspase 9	Homo sapiens	260-269
20643202-10	2011	Curcumin stabilized IkappaBalpha and inhibited nuclear translocation of p65 and p50 in LPS-activated Raw264.7 cells, and curcumin-treated mice showed reduced nuclear translocation of p65 in lung tissue.	Curcumin	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	72-75
20643202-10	2011	Curcumin stabilized IkappaBalpha and inhibited nuclear translocation of p65 and p50 in LPS-activated Raw264.7 cells, and curcumin-treated mice showed reduced nuclear translocation of p65 in lung tissue.	Curcumin	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	183-186
20643202-10	2011	Curcumin stabilized IkappaBalpha and inhibited nuclear translocation of p65 and p50 in LPS-activated Raw264.7 cells, and curcumin-treated mice showed reduced nuclear translocation of p65 in lung tissue.	Curcumin	121-129	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	183-186
21493306-4	2011	It is hypothesized that curcumin has growth-inhibitory effects through the TOR pathway and chemopreventive potential in skin SCCa where local application could bypass bioavailability problems.	Curcumin	24-32	tortured	Mus musculus	75-78
21493306-12	2011	Curcumin inhibited S6 phosphorylation (P = .0027), suggest-ing inhibition of the MTOR pathway.	Curcumin	0-8	mechanistic target of rapamycin kinase	Mus musculus	81-85
21713389-8	2011	Curcumin proved to lower HIF-1alpha and HIF-2alpha protein levels in hypoxia.	Curcumin	0-8	endothelial PAS domain protein 1	Homo sapiens	40-50
21570847-2	2011	A tartarate-resistant acid phosphatase (TRAP) activity assay was carried out with RANKL-induced osteoclastogenesis of mouse monocyte/macrophage RAW264.7 cells; the results indicated that the curcumin mimics derived from intermediate 10 exhibited stronger inhibitory activity than 9.	Curcumin	191-199	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	82-87
20815812-0	2011	Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer.	Curcumin	0-8	microRNA 21	Homo sapiens	19-25
20815812-3	2011	In the present study, we examined the potential of curcumin to regulate miR-21, tumour growth, invasion and in vivo metastasis in colorectal cancer.	Curcumin	51-59	microRNA 21	Homo sapiens	72-78
20815812-6	2011	Curcumin treatment reduced miR-21 promoter activity and expression in a dose-dependent manner by inhibiting AP-1 binding to the promoter, and induced the expression of the tumour suppressor Pdcd4 (programmed cell death protein 4), which is a target of miR-21.	Curcumin	0-8	microRNA 21	Homo sapiens	27-33
20815812-6	2011	Curcumin treatment reduced miR-21 promoter activity and expression in a dose-dependent manner by inhibiting AP-1 binding to the promoter, and induced the expression of the tumour suppressor Pdcd4 (programmed cell death protein 4), which is a target of miR-21.	Curcumin	0-8	microRNA 21	Homo sapiens	252-258
20815812-9	2011	Additionally, curcumin significantly inhibited miR-21 expression in primary tumours generated in vivo in the CAM assay by Rko and HCT116 cells (P&lt;0.00006 and P&lt;0.035 respectively).	Curcumin	14-22	microRNA 21	Homo sapiens	47-53
20815812-10	2011	Taken together, this is the first paper to show that curcumin inhibits the transcriptional regulation of miR-21 via AP-1, suppresses cell proliferation, tumour growth, invasion and in vivo metastasis, and stabilizes the expression of the tumour suppressor Pdcd4 in colorectal cancer.	Curcumin	53-61	microRNA 21	Homo sapiens	105-111
21345977-0	2011	Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model.	Curcumin	0-8	polycystin 1, transient receptor potential channel interacting	Mus musculus	116-120
21345977-5	2011	To test this hypothesis, we treated Pkd1-deletion mice with diferuloylmethane (curcumin), a compound without appreciable side effects and known to modulate several pathways that are also altered in ADPKD, e.g., mammalian target of rapamycin (mTOR) and Wnt signaling.	Curcumin	60-77	polycystin 1, transient receptor potential channel interacting	Mus musculus	36-40
21345977-5	2011	To test this hypothesis, we treated Pkd1-deletion mice with diferuloylmethane (curcumin), a compound without appreciable side effects and known to modulate several pathways that are also altered in ADPKD, e.g., mammalian target of rapamycin (mTOR) and Wnt signaling.	Curcumin	79-87	polycystin 1, transient receptor potential channel interacting	Mus musculus	36-40
21345977-9	2011	Importantly, Pkd1-deletion mice that were treated with curcumin and killed at an early stage of PKD displayed improved renal histology and reduced STAT3 activation, proliferation index, cystic index, and kidney weight/body weight ratios.	Curcumin	55-63	polycystin 1, transient receptor potential channel interacting	Mus musculus	13-17
32202049-3	2020	The results showed that curcumin significantly promoted the cellular activity of AXN-treated RIN-m5F cells, decreased the ratio of apoptosis, downregulated the level of malondialdehyde, upregulated the levels of superoxide dismutase and reactive oxygen species, increased the expression of Bcl-2, cleaved caspase-3, and cleaved PARP1, and decreased the expression of Bax in AXN-treated cells.	Curcumin	24-32	poly (ADP-ribose) polymerase 1	Rattus norvegicus	328-333
21506134-5	2011	In addition, curcumin (10 microm) significantly enhanced the cellular accumulation of rhodamine-123 in MCF-7/ADR cells overexpressing P-gp.	Curcumin	13-21	phosphoglycolate phosphatase	Homo sapiens	134-138
22145830-7	2012	Furthermore, our results show that both curcumin and DMC, but not BDMC, induced phosphorylation of cAMP response element-binding protein (CREB) and CRE-reporter gene activity significantly (p &lt; 0.05).	Curcumin	40-48	cAMP responsive element binding protein 1	Rattus norvegicus	99-136
22145830-7	2012	Furthermore, our results show that both curcumin and DMC, but not BDMC, induced phosphorylation of cAMP response element-binding protein (CREB) and CRE-reporter gene activity significantly (p &lt; 0.05).	Curcumin	40-48	cAMP responsive element binding protein 1	Rattus norvegicus	138-142
22145830-9	2012	Moreover, activation of CREB coupling with CRE-dependent gene transcription may play a vital role for curcumin- or DMC-induced PC12 differentiation.	Curcumin	102-110	cAMP responsive element binding protein 1	Rattus norvegicus	24-28
22212430-11	2012	The AP-1 inhibitor curcumin (1-10 mumol/L) concentration-dependently attenuated thrombin-induced CTGF expression.	Curcumin	19-27	cellular communication network factor 2	Rattus norvegicus	97-101
21295102-8	2011	The Bax/Bcl-2 ratio increased significantly after 1h pretreatment with curcumin.	Curcumin	71-79	BCL2 associated X, apoptosis regulator	Rattus norvegicus	4-7
22038826-5	2012	Curcumin inhibited IFN-gamma-induced gene transcription, including CII-TA, MHC-II genes (HLA-DRalpha, HLA-DPalpha1, HLA-DRbeta1), and T cell chemokines (CXCL9, 10, and 11).	Curcumin	0-8	class II major histocompatibility complex transactivator	Homo sapiens	67-73
21311958-9	2011	This time-dependent drop in curcumin level was found to be due to induction of CYP1A1 and GSTM (mu) enzymes which led to increased metabolism of curcumin.	Curcumin	28-36	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	79-85
32202049-3	2020	The results showed that curcumin significantly promoted the cellular activity of AXN-treated RIN-m5F cells, decreased the ratio of apoptosis, downregulated the level of malondialdehyde, upregulated the levels of superoxide dismutase and reactive oxygen species, increased the expression of Bcl-2, cleaved caspase-3, and cleaved PARP1, and decreased the expression of Bax in AXN-treated cells.	Curcumin	24-32	BCL2 associated X, apoptosis regulator	Rattus norvegicus	367-370
21311958-9	2011	This time-dependent drop in curcumin level was found to be due to induction of CYP1A1 and GSTM (mu) enzymes which led to increased metabolism of curcumin.	Curcumin	145-153	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	79-85
21842651-6	2011	RESULT: The expression of ATP synthesis H+ transporting, MHC class II, non-muscle myosin alkali light chain and cytochrome b5 increased in the RAW264.7 cell treated with 25 micromol x L(-1) curcumin, while the expression of phosphodiesterase 4D, elF-3, Hnrpf protein, vimentin, nucleophosminl and Ranbp 1 decreased.	Curcumin	190-198	RAN binding protein 1	Mus musculus	297-304
22005927-9	2012	CONCLUSION: Curcumin suppresses ox-LDL-induced MCP-1 expression in VSMCs via the p38 MAPK and NF-kappaB pathways, which suggests that the anti-inflammatory effect of curcumin is related to the down-regulation of MCP-1 expression and offers a new theoretical basis in the anti-inflammatory effects of curcumin.	Curcumin	12-20	C-C motif chemokine ligand 2	Rattus norvegicus	47-52
22005927-9	2012	CONCLUSION: Curcumin suppresses ox-LDL-induced MCP-1 expression in VSMCs via the p38 MAPK and NF-kappaB pathways, which suggests that the anti-inflammatory effect of curcumin is related to the down-regulation of MCP-1 expression and offers a new theoretical basis in the anti-inflammatory effects of curcumin.	Curcumin	12-20	C-C motif chemokine ligand 2	Rattus norvegicus	212-217
22005927-9	2012	CONCLUSION: Curcumin suppresses ox-LDL-induced MCP-1 expression in VSMCs via the p38 MAPK and NF-kappaB pathways, which suggests that the anti-inflammatory effect of curcumin is related to the down-regulation of MCP-1 expression and offers a new theoretical basis in the anti-inflammatory effects of curcumin.	Curcumin	166-174	C-C motif chemokine ligand 2	Rattus norvegicus	47-52
22005927-9	2012	CONCLUSION: Curcumin suppresses ox-LDL-induced MCP-1 expression in VSMCs via the p38 MAPK and NF-kappaB pathways, which suggests that the anti-inflammatory effect of curcumin is related to the down-regulation of MCP-1 expression and offers a new theoretical basis in the anti-inflammatory effects of curcumin.	Curcumin	166-174	C-C motif chemokine ligand 2	Rattus norvegicus	212-217
32802291-9	2020	CU+LLLT decreases Bax/Bcl2 ratio which is an indicator of apoptosis and it also rescued a decrease in LC3 and ATG10 expression in comparison with 6-OHDA group.	Curcumin	0-2	BCL2 associated X, apoptosis regulator	Rattus norvegicus	18-21
32802291-10	2020	Conclusion: This study shows that the combination of 5 muM CU and LLLT has the best neuroprotective effect on PC12 cells against 6-OHDA by decreasing the BAX/BCL2 ratio.	Curcumin	59-61	BCL2 associated X, apoptosis regulator	Rattus norvegicus	154-157
32506808-2	2020	Curcumin circulates as an inactive glucuronide that can be deconjugated in situ by bone"s high beta-glucuronidase (GUSB) content, forming the active aglycone.	Curcumin	0-8	glucuronidase, beta	Mus musculus	115-119
22690125-8	2012	Curcumin can attenuate cancer via a reduction of phospho-IkappaBalpha and 8-OHdG expressions, which may play a promising role in gastric carcinogenesis.	Curcumin	0-8	NFKB inhibitor alpha	Rattus norvegicus	57-69
21443863-0	2011	Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling.	Curcumin	0-8	interleukin 2	Mus musculus	76-80
21443863-2	2011	Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4(+) T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 (alpha chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28.	Curcumin	47-55	interleukin 2	Mus musculus	137-141
21443863-2	2011	Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4(+) T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 (alpha chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28.	Curcumin	47-55	CD28 antigen	Mus musculus	270-274
21443863-4	2011	In addition, IL-2-dependent DNA synthesis by mouse CTLL-2 cells, but not constitutive CD25 expression, was impaired in the presence of curcumin, which demonstrated an inhibitory effect on IL-2 receptor (IL-2R) signaling.	Curcumin	135-143	interleukin 2	Mus musculus	13-17
21830091-3	2012	The structure-activity relationships of those curcumin-like diarylpentanoid analogues which inhibited the melanogenesis and tyrosinase activity were also discussed.	Curcumin	46-54	tyrosinase	Mus musculus	124-134
21443863-5	2011	IL-2-induced phosphorylation of STAT5A and JAK3, but not JAK1, was diminished in the presence of curcumin, indicating inhibition of critical proximal events in IL-2R signaling.	Curcumin	97-105	interleukin 2	Mus musculus	0-4
32506808-7	2020	GUSB also catalyzed deconjugation of resveratrol and quercetin glucuronides by bone, and a requirement for the aglycones for anti-osteoclastogenic bioactivity, analogous to curcumin, was confirmed.	Curcumin	173-181	glucuronidase, beta	Mus musculus	0-4
21443863-5	2011	IL-2-induced phosphorylation of STAT5A and JAK3, but not JAK1, was diminished in the presence of curcumin, indicating inhibition of critical proximal events in IL-2R signaling.	Curcumin	97-105	signal transducer and activator of transcription 5A	Mus musculus	32-38
21443863-6	2011	In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4(+)CD25(+) regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression.	Curcumin	121-129	forkhead box P3	Mus musculus	193-198
32506808-9	2020	Curcumin and other dietary polyphenols are bone protective and block RANKL-stimulated osteoclastogenesis.	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	69-74
21443863-7	2011	We conclude that curcumin inhibits IL-2 signaling by reducing available IL-2 and high affinity IL-2R, as well as interfering with IL-2R signaling.	Curcumin	17-25	interleukin 2	Mus musculus	35-39
21443863-7	2011	We conclude that curcumin inhibits IL-2 signaling by reducing available IL-2 and high affinity IL-2R, as well as interfering with IL-2R signaling.	Curcumin	17-25	interleukin 2	Mus musculus	72-76
32097726-0	2020	A new insight into purification of polyphenol oxidase and inhibition effect of curcumin and quercetin on potato polyphenol oxidase.	Curcumin	79-87	catechol oxidase B, chloroplastic	Solanum tuberosum	112-130
21352912-0	2011	Curcumin activates Wnt/beta-catenin signaling pathway through inhibiting the activity of GSK-3beta in APPswe transfected SY5Y cells.	Curcumin	0-8	catenin beta 1	Homo sapiens	23-35
21352912-2	2011	The study aims to investigate the effect of Curcumin on the expression of GSK-3beta, beta-catenin and CyclinD1 in vitro, which are tightly correlated with Wnt/beta-catenin signaling pathway, and also to explore the mechanisms, which will provide a novel therapeutic intervention for treatment of Alzheimer"s disease.	Curcumin	44-52	catenin beta 1	Homo sapiens	85-97
21352912-2	2011	The study aims to investigate the effect of Curcumin on the expression of GSK-3beta, beta-catenin and CyclinD1 in vitro, which are tightly correlated with Wnt/beta-catenin signaling pathway, and also to explore the mechanisms, which will provide a novel therapeutic intervention for treatment of Alzheimer"s disease.	Curcumin	44-52	catenin beta 1	Homo sapiens	159-171
21352912-5	2011	Cell lysates were collected for RT-PCR, Western blot assay and immunofluorescent staining were carried out for detecting the effect of Curcumin on the expression of GSK-3beta, beta-catenin and CyclinD1.	Curcumin	135-143	catenin beta 1	Homo sapiens	176-188
21352912-8	2011	Immunofluorescent staining results not only confirmed the above changes, but also showed that beta-catenin had translocated into the nucleus gradually with the increased dosage of Curcumin.	Curcumin	180-188	catenin beta 1	Homo sapiens	94-106
22343730-7	2012	In our studies, systemic curcumin is administered to enable monitoring of retinal Abeta plaques in live APP(SWE)/PS1(Delta)(E9) transgenic mice by optical imaging.	Curcumin	25-33	amyloid beta (A4) precursor protein	Mus musculus	82-87
22343730-7	2012	In our studies, systemic curcumin is administered to enable monitoring of retinal Abeta plaques in live APP(SWE)/PS1(Delta)(E9) transgenic mice by optical imaging.	Curcumin	25-33	presenilin 1	Mus musculus	113-116
23285282-12	2012	Curcumin inhibited the RPE-choroid levels of TNF-alpha (P&lt;0.05), MCP-1 (P&lt;0.05) and ICAM-1 (P&lt;0.05), and suppressed the activation of NF-kappaB in nuclear extracts (P&lt;0.05) and the activation of HIF-1alpha (P&lt;0.05).	Curcumin	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	207-217
23285282-13	2012	CONCLUSION: Curcumin treatment led to the suppression of CNV development together with inflammatory and angiogenic processes including NF-kappaB and HIF-1alpha activation, the up-regulation of inflammatory and angiogenic cytokines, and infiltrating macrophages and granulocytes.	Curcumin	12-20	hypoxia inducible factor 1, alpha subunit	Mus musculus	149-159
23152782-11	2012	Western blot analysis suggested that pretreatment with Ki-67-7 sensitized bladder cancer cells to curcumin-mediated apoptosis and cell cycle arrest by p53- and p21-independent mechanisms.	Curcumin	98-106	H3 histone pseudogene 16	Homo sapiens	160-163
21352912-10	2011	Curcumin could activate the Wnt/beta-catenin signaling pathway through inhibiting the expression of GSK-3beta and inducing the expression of beta-catenin and CyclinD1, which will provide a new theory for treatment of neurodegenerative diseases by Curcumin.	Curcumin	0-8	catenin beta 1	Homo sapiens	32-44
21352912-10	2011	Curcumin could activate the Wnt/beta-catenin signaling pathway through inhibiting the expression of GSK-3beta and inducing the expression of beta-catenin and CyclinD1, which will provide a new theory for treatment of neurodegenerative diseases by Curcumin.	Curcumin	0-8	catenin beta 1	Homo sapiens	141-166
32097726-8	2020	IC50 values were determined to be 0.018 and 0.029 mM for potato PPO with curcumin and quercetin inhibitors with catechol as a substrate, respectively.	Curcumin	73-81	catechol oxidase B, chloroplastic	Solanum tuberosum	64-67
32617134-8	2020	Further, curcumin-induced DNA demethylation of hGCCs was mediated by the damaged DNA repair-p53-p21/GADD45A-cyclin/CDK-Rb/E2F-DNMT1 axis.	Curcumin	9-17	proliferating cell nuclear antigen	Homo sapiens	108-114
21352912-10	2011	Curcumin could activate the Wnt/beta-catenin signaling pathway through inhibiting the expression of GSK-3beta and inducing the expression of beta-catenin and CyclinD1, which will provide a new theory for treatment of neurodegenerative diseases by Curcumin.	Curcumin	247-255	catenin beta 1	Homo sapiens	32-44
21609281-8	2011	Decreased activities of hepatic glutathione reductase and glutathione-S-transferase caused by the lithogenic diet were countered by the combination of capsaicin and curcumin.	Curcumin	165-173	hematopoietic prostaglandin D synthase	Mus musculus	58-83
22431984-7	2012	In addition, TNF-alpha was undetectable from serum or vaginal tissue of curcumin treated rabbits that survived.	Curcumin	72-80	tumor necrosis factor	Oryctolagus cuniculus	13-22
21887696-4	2011	Treatment of SCC-4 cells with curcumin caused a moderate and promoted the G(2) /M phase arrest, which was accompanied with decreases in cyclin B/CDK1 and CDC25C protein levels.	Curcumin	30-38	cyclin dependent kinase 1	Homo sapiens	145-149
31955141-0	2020	Curcumin-loaded nanostructured lipid carrier induced apoptosis in human HepG2 cells through activation of the DR5/caspase-mediated extrinsic apoptosis pathway.	Curcumin	0-8	TNF receptor superfamily member 10b	Homo sapiens	110-113
21887696-4	2011	Treatment of SCC-4 cells with curcumin caused a moderate and promoted the G(2) /M phase arrest, which was accompanied with decreases in cyclin B/CDK1 and CDC25C protein levels.	Curcumin	30-38	cell division cycle 25C	Homo sapiens	154-160
21998146-7	2011	Inhibition of AP-1 activity by curcumin attenuated the S1P-induced FN expression.	Curcumin	31-39	fibronectin 1	Rattus norvegicus	67-69
22058071-5	2011	Aortic arch sections revealed curcumin ameliorated early atherosclerotic lesions, lipid infiltration, ICAM-1 and VCAM-1 localization, similar to lovastatin treatment.	Curcumin	30-38	vascular cell adhesion molecule 1	Mus musculus	113-119
22058071-6	2011	Furthermore, curcumin lowered plasma cholesterol, triglycerides, LDL cholesterol and Apo B levels as well as CETP activity, while curcumin increased plasma HDL cholesterol and liver Apo A-I expression, similar to lovastatin treatment.	Curcumin	13-21	apolipoprotein B	Mus musculus	85-90
22113581-0	2011	A curcumin derivative, 2,6-bis(2,5-dimethoxybenzylidene)-cyclohexanone (BDMC33) attenuates prostaglandin E2 synthesis via selective suppression of cyclooxygenase-2 in IFN-gamma/LPS-stimulated macrophages.	Curcumin	2-10	interferon regulatory factor 6	Homo sapiens	177-180
21236354-3	2011	Furthermore, exposure of cells to 10-50 muM curcumin for 24h induced HSP30 and HSP70 accumulation.	Curcumin	44-52	heat shock 70kDa protein L homeolog	Xenopus laevis	79-84
21236354-5	2011	Additionally, elevation of the incubation temperature from 22 to 30  C greatly enhanced the curcumin-induced accumulation of HSP30 and HSP70.	Curcumin	92-100	heat shock 70kDa protein L homeolog	Xenopus laevis	135-140
21236599-3	2011	Accordingly, we investigated the effect of curcumin in inhibiting IR-induced NFkappaB-dependent hTERT transcription, TA, and cell survival in neuroblastoma cells.	Curcumin	43-51	telomerase reverse transcriptase	Homo sapiens	96-101
21372035-3	2011	Curcumin reduces mucosal concentrations of PGE2 (via inhibition of cyclooxygenases 1 and 2) and 5-HETE (via inhibition of 5-lipoxygenase) in rats.	Curcumin	0-8	arachidonate 5-lipoxygenase	Rattus norvegicus	122-136
21821729-7	2011	Pretreatment with curcumin blocked the hyperoxia-induced decrease (PPARgamma and ADRP) and increase (alpha-smooth muscle actin and fibronectin) in markers of lung injury/repair, as well as the activation of TGF-beta signaling.	Curcumin	18-26	actin gamma 2, smooth muscle	Rattus norvegicus	101-126
21821729-7	2011	Pretreatment with curcumin blocked the hyperoxia-induced decrease (PPARgamma and ADRP) and increase (alpha-smooth muscle actin and fibronectin) in markers of lung injury/repair, as well as the activation of TGF-beta signaling.	Curcumin	18-26	fibronectin 1	Rattus norvegicus	131-142
21304405-0	2011	Use of curcumin to decrease nitric oxide production during the induction of antitumor responses by IL-2.	Curcumin	7-15	interleukin 2	Mus musculus	99-103
32128952-6	2020	Moreover, expression levels of BAX, BCL-2, and CASP9 genes were assessed among AGS cells treated with curcumin, doxorubicin, and Dox-Cur.	Curcumin	102-110	caspase 9	Homo sapiens	47-52
21304405-4	2011	Curcumin inhibited inducible nitric oxide synthase (iNOS) expression and NO production, and thereby enhanced the proliferation and cytotoxic activity of cocultured lymphocytes and macrophages during IL-2 stimulation which we earlier established as an in vitro model of IL-2-induced NO synthesis.	Curcumin	0-8	interleukin 2	Mus musculus	199-203
21304405-4	2011	Curcumin inhibited inducible nitric oxide synthase (iNOS) expression and NO production, and thereby enhanced the proliferation and cytotoxic activity of cocultured lymphocytes and macrophages during IL-2 stimulation which we earlier established as an in vitro model of IL-2-induced NO synthesis.	Curcumin	0-8	interleukin 2	Mus musculus	269-273
21968503-15	2011	As both oxidative stress and PAI-1 production were reduced by simvastatin and curcumin, modulation of oxidative stress and PAI-1 production are attractive targets for pharmacotherapy of cardiovascular disorders associated with an increased PAI-1 including type 2 diabetes and its associated consequences including accelerated coronary artery disease and an increased fibrosis that may exacerbate adverse left ventricular remodeling after myocardial infarction.	Curcumin	78-86	serpin family E member 1	Homo sapiens	29-34
21968503-13	2011	TGF-beta-inducible PAI-1 expression was attenuated by simvastatin and curcumin, a natural polyphenol.	Curcumin	70-78	serpin family E member 1	Homo sapiens	19-24
22199113-9	2011	RESULTS: Curcumin significantly decreased the pancreas injury and reversed the elevation of serum amylase, ALT and AST activities and TNF-alpha level in mice with AP.	Curcumin	9-17	glutamic pyruvic transaminase, soluble	Mus musculus	107-110
22199113-9	2011	RESULTS: Curcumin significantly decreased the pancreas injury and reversed the elevation of serum amylase, ALT and AST activities and TNF-alpha level in mice with AP.	Curcumin	9-17	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	115-118
21304405-5	2011	Curcumin also decreased apoptosis of cocultured lymphocytes and macrophages during IL-2 stimulation.	Curcumin	0-8	interleukin 2	Mus musculus	83-87
21304405-6	2011	In contrast, the curcumin-induced changes in proliferation and apoptosis were not observed in cultures of lymphocytes alone, macrophages alone, and cocultured lymphocytes/iNOS-knock out macrophages, all of which produced little nitrite during IL-2 stimulation.	Curcumin	17-25	interleukin 2	Mus musculus	243-247
21304405-7	2011	In conjunction with IL-2 treatment, oral curcumin administration significantly inhibited IL-2 therapy-induced urinary nitrite/nitrate excretion and iNOS expression of tumor tissues, and further increased the IL-2 therapy-induced prolongation of survival in a murine Meth-A ascites tumor model.	Curcumin	41-49	interleukin 2	Mus musculus	20-24
22199113-10	2011	Curcumin treatment inhibited the elevation of NF-kappaB-p65 in the nucleus of mouse pancreas AP group and RAW264.7 cells, but significantly increased the expression of PPARgamma.	Curcumin	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	56-59
32081769-0	2020	The role of miR-21/RECK in the inhibition of osteosarcoma by curcumin.	Curcumin	61-69	microRNA 21	Homo sapiens	12-18
22199113-11	2011	GW9662 could abolish the effects of curcumin on serum levels of amylase, ALT, AST, TNF-alpha, and NF-kappaB level.	Curcumin	36-44	glutamic pyruvic transaminase, soluble	Mus musculus	73-76
22199113-11	2011	GW9662 could abolish the effects of curcumin on serum levels of amylase, ALT, AST, TNF-alpha, and NF-kappaB level.	Curcumin	36-44	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	78-81
32081769-6	2020	However, the role of miR-21 and its target gene, reversion-inducing cysteine-rich protein with kazal motifs (RECK), in the anticancer activity of curcumin against osteosarcoma remains unclear.	Curcumin	146-154	microRNA 21	Homo sapiens	21-27
21732406-5	2011	Curcumin suppressed OC formation by increasing receptor activator of nuclear factor-kappaB ligand (RANKL)-induced glutathione peroxidase-1, and reversed the stimulatory effect of homocysteine, a known H(2) O(2) generator, on OC formation by restoring Gpx activity.	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	47-97
32081769-11	2020	We hereby show that curcumin upregulated the expression of RECK via miR-21, thereby subsequently regulating Wnt/beta-catenin signaling leading to the inhibition of osteosarcoma.	Curcumin	20-28	microRNA 21	Homo sapiens	68-74
21732406-5	2011	Curcumin suppressed OC formation by increasing receptor activator of nuclear factor-kappaB ligand (RANKL)-induced glutathione peroxidase-1, and reversed the stimulatory effect of homocysteine, a known H(2) O(2) generator, on OC formation by restoring Gpx activity.	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	99-104
21732406-5	2011	Curcumin suppressed OC formation by increasing receptor activator of nuclear factor-kappaB ligand (RANKL)-induced glutathione peroxidase-1, and reversed the stimulatory effect of homocysteine, a known H(2) O(2) generator, on OC formation by restoring Gpx activity.	Curcumin	0-8	glutathione peroxidase 1	Mus musculus	114-138
21304405-7	2011	In conjunction with IL-2 treatment, oral curcumin administration significantly inhibited IL-2 therapy-induced urinary nitrite/nitrate excretion and iNOS expression of tumor tissues, and further increased the IL-2 therapy-induced prolongation of survival in a murine Meth-A ascites tumor model.	Curcumin	41-49	interleukin 2	Mus musculus	89-93
21304405-7	2011	In conjunction with IL-2 treatment, oral curcumin administration significantly inhibited IL-2 therapy-induced urinary nitrite/nitrate excretion and iNOS expression of tumor tissues, and further increased the IL-2 therapy-induced prolongation of survival in a murine Meth-A ascites tumor model.	Curcumin	41-49	interleukin 2	Mus musculus	89-93
21304405-8	2011	Curcumin may be useful as an adjunct to increase the antitumor activity of IL-2 therapy.	Curcumin	0-8	interleukin 2	Mus musculus	75-79
21282356-5	2011	Curcumin-mediated ER stress via inhibiting the activity of SERCA2 caused increasing expressions of CHOP and its transcription target death receptor 5 (TRAIL-R2), leading to a caspase-3 and caspase-8 cascade-dependent apoptosis in SW872 cells in vitro and in vivo.	Curcumin	0-8	TNF receptor superfamily member 10b	Homo sapiens	133-149
32081769-11	2020	We hereby show that curcumin upregulated the expression of RECK via miR-21, thereby subsequently regulating Wnt/beta-catenin signaling leading to the inhibition of osteosarcoma.	Curcumin	20-28	catenin beta 1	Homo sapiens	112-124
21282356-5	2011	Curcumin-mediated ER stress via inhibiting the activity of SERCA2 caused increasing expressions of CHOP and its transcription target death receptor 5 (TRAIL-R2), leading to a caspase-3 and caspase-8 cascade-dependent apoptosis in SW872 cells in vitro and in vivo.	Curcumin	0-8	TNF receptor superfamily member 10b	Homo sapiens	151-159
21311744-0	2011	Effect of curcumin on the modulation of alphaA- and alphaB-crystallin and heat shock protein 70 in selenium-induced cataractogenesis in Wistar rat pups.	Curcumin	10-18	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	74-95
20719539-6	2011	Combination treatment with curcumin and candesartan significantly restored SOD and GST activity, thiobarbituric acid reactive substances, heart rate, blood flow, and red color intensity compared with the untreated group.	Curcumin	27-35	hematopoietic prostaglandin D synthase	Mus musculus	83-86
22045654-7	2011	Curcumin also attenuated the expression of TGF-beta1, CTGF, osteopontin, p300 and ECM proteins such as fibronectin and type IV collagen.	Curcumin	0-8	cellular communication network factor 2	Rattus norvegicus	54-58
21311744-1	2011	PURPOSE: To investigate the expression of alphaA- and alphaB-crystallin and heat shock protein 70 (Hsp 70) during curcumin treatment of selenium-induced cataractogenesis in Wistar rat pups.	Curcumin	114-122	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	99-105
22045654-7	2011	Curcumin also attenuated the expression of TGF-beta1, CTGF, osteopontin, p300 and ECM proteins such as fibronectin and type IV collagen.	Curcumin	0-8	fibronectin 1	Rattus norvegicus	103-114
21311744-10	2011	CONCLUSIONS: Curcumin suppressed the expression of selenite-induced alphaA- and alphaB-crystallin and Hsp 70, and may therefore suppress cataract formation in rat pups.	Curcumin	13-21	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	51-108
22045654-8	2011	The high-glucose-induced expression of VEGF and its receptor VEGF receptor II (flk-1) was also ameliorated by curcumin.	Curcumin	110-118	vascular endothelial growth factor A	Rattus norvegicus	39-43
32528227-11	2020	Both enzymatic (GST, catalase, and SOD) and nonenzymatic antioxidants (reduced GSH) were raised significantly in the presence of vitamin D3 and curcumin, which resulted in the better recovery of neuronal cells from Abeta1-42 treatment.	Curcumin	144-152	glutathione S-transferase kappa 1	Homo sapiens	16-19
22045654-8	2011	The high-glucose-induced expression of VEGF and its receptor VEGF receptor II (flk-1) was also ameliorated by curcumin.	Curcumin	110-118	vascular endothelial growth factor A	Rattus norvegicus	61-65
22045654-8	2011	The high-glucose-induced expression of VEGF and its receptor VEGF receptor II (flk-1) was also ameliorated by curcumin.	Curcumin	110-118	kinase insert domain receptor	Rattus norvegicus	79-84
21896275-8	2011	p300/CBP-specific inhibitor curcumin can reverse the induction of p16(INK4a) by p33(ING1b).	Curcumin	28-36	inhibitor of growth family member 1	Homo sapiens	80-83
22005428-9	2011	In contrast, IFN-gamma and IL-2 mRNA levels were lower at the end of the citrus and the curcumin supplementation, respectively.	Curcumin	88-96	interleukin 2	Felis catus	27-31
21484797-9	2011	In two in vivo studies, [DLys(6)]-LHRH-curcumin given intravenously caused a significant (p &lt; 0.01) reduction in tumor weights and volumes, and free curcumin given by gavage at an equal dose failed to cause a significant reduction in tumor weights and volumes in the nude mouse pancreatic cancer model.	Curcumin	39-47	gonadotropin releasing hormone 1	Mus musculus	34-38
21237663-0	2011	Identification of curcumin derivatives as human glyoxalase I inhibitors: A combination of biological evaluation, molecular docking, 3D-QSAR and molecular dynamics simulation studies.	Curcumin	18-26	glyoxalase I	Homo sapiens	48-60
21237663-2	2011	In present study, a series of curcumin derivatives with high inhibitory activity against human GLO I were discovered.	Curcumin	30-38	glyoxalase I	Homo sapiens	95-100
21499987-3	2011	Data from our and other laboratories have previously demonstrated that curcumin, the yellow pigment of curry, strongly induces heme-oxygenase-1 (HO-1) expression and activity in different brain cells via the activation of heterodimers of NF-E2-related factors 2 (Nrf2)/antioxidant responsive element (ARE) pathway.	Curcumin	71-79	heme oxygenase 1	Homo sapiens	127-143
32523525-10	2020	Following similar rationale NPs of poly(lactide-co-glycolide)-poly (ethylene glycol) conjugated with curcumin-derivate (PLGA-PEG-B6/Cur) were reported to improve the spatial learning and memory capability of APP/PS1 mice, compared with native curcumin treatment.	Curcumin	101-109	presenilin 1	Mus musculus	212-215
21499987-3	2011	Data from our and other laboratories have previously demonstrated that curcumin, the yellow pigment of curry, strongly induces heme-oxygenase-1 (HO-1) expression and activity in different brain cells via the activation of heterodimers of NF-E2-related factors 2 (Nrf2)/antioxidant responsive element (ARE) pathway.	Curcumin	71-79	heme oxygenase 1	Homo sapiens	145-149
21519785-6	2011	In addition, curcumin significantly inactivated p38 mitogen-activated protein kinases (MAPK) and stress-activated protein kinase/c-Jun N-terminal kinases (SARK/JNK), coupled with inhibition of p53 and p21 tumor suppressor gene products.	Curcumin	13-21	transformation related protein 53, pseudogene	Mus musculus	193-196
22362715-0	2011	Curcumin inhibits the migration and invasion of mouse hepatoma Hca-F cells through down-regulating caveolin-1 expression and epidermal growth factor receptor signaling.	Curcumin	0-8	caveolin 1, caveolae protein	Mus musculus	99-109
22362715-0	2011	Curcumin inhibits the migration and invasion of mouse hepatoma Hca-F cells through down-regulating caveolin-1 expression and epidermal growth factor receptor signaling.	Curcumin	0-8	epidermal growth factor receptor	Mus musculus	125-157
22362715-5	2011	Curcumin inhibited the expression of the tumor promoter caveolin-1 (Cav-1) in Hca-F cells.	Curcumin	0-8	caveolin 1, caveolae protein	Mus musculus	56-66
22362715-5	2011	Curcumin inhibited the expression of the tumor promoter caveolin-1 (Cav-1) in Hca-F cells.	Curcumin	0-8	caveolin 1, caveolae protein	Mus musculus	68-73
22362715-6	2011	Up-regulation of Cav-1 expression by pcDNA3.1/Cav-1 plasmid was able to reverse the curcumin-induced antimigration and anti-invasion effects in vitro.	Curcumin	84-92	caveolin 1, caveolae protein	Mus musculus	17-22
22362715-6	2011	Up-regulation of Cav-1 expression by pcDNA3.1/Cav-1 plasmid was able to reverse the curcumin-induced antimigration and anti-invasion effects in vitro.	Curcumin	84-92	caveolin 1, caveolae protein	Mus musculus	46-51
22362715-7	2011	Curcumin down-regulated the expression of cluster of differntiation (CD)147, matrix metalloproteinase 2, and matrix metalloproteinase 9 and inhibited the phosphorylation of epidermal growth factor receptor (EGFR), the phosphoinositilde 3-kinase (PI3K)/protein kinase B (Akt), p38 mitogen-activated protein kinase (MAPK), and p44/42MAPK in Hca-F cells.	Curcumin	0-8	epidermal growth factor receptor	Mus musculus	173-205
22362715-7	2011	Curcumin down-regulated the expression of cluster of differntiation (CD)147, matrix metalloproteinase 2, and matrix metalloproteinase 9 and inhibited the phosphorylation of epidermal growth factor receptor (EGFR), the phosphoinositilde 3-kinase (PI3K)/protein kinase B (Akt), p38 mitogen-activated protein kinase (MAPK), and p44/42MAPK in Hca-F cells.	Curcumin	0-8	epidermal growth factor receptor	Mus musculus	207-211
22362715-8	2011	Taken together, our findings suggest that curcumin can suppress the migratory and invasive ability of mouse hepatoma Hca-F cells, and this action is mediated through a novel mechanism involving inactivation of Cav-1 and EGFR signaling pathways.	Curcumin	42-50	caveolin 1, caveolae protein	Mus musculus	210-215
21134073-3	2011	The effects of isoflavones and curcumin on the expression and phosphorylation of ataxia-telangiectasia-mutated kinase (ATM), histone H2AX variant (H2AX) and checkpoint kinase2 (Chk2) were examined in LNCaP cells.	Curcumin	31-39	ATM serine/threonine kinase	Homo sapiens	119-122
21134073-6	2011	Combined treatment of isoflavones and curcumin additively suppressed cellular proliferation and induced phosphorylation of ATM, histone H2AX, Chk2 and p53.	Curcumin	38-46	ATM serine/threonine kinase	Homo sapiens	123-126
22292626-4	2011	Annexin-V/PI double staining detected by flow cytometry and expression of the relative apoptotic proteins (Bax, Bcl-2 and caspase-3) revealed a strong apoptosis-inducing competent of curcumin in SMMC-7721 cells.	Curcumin	183-191	annexin A5	Homo sapiens	0-9
21415532-11	2011	Curcumin also significantly inhibited the expression of MCP-1 and IL-2 mRNA in HK-2 cells, and partially inhibited the secretion of MCP-1 and IL-8.	Curcumin	0-8	interleukin 2	Mus musculus	66-70
22189739-13	2011	All of the cells in mice treated with curcumin were p21 positive, suggesting that the p53 pathway is induced by this compound.	Curcumin	38-46	transformation related protein 53, pseudogene	Mus musculus	86-89
22189739-15	2011	CONCLUSION: Curcumin showed activity in this animal bladder cancer model and probably acted via the regulation of nuclear factor-kappa B and p53.	Curcumin	12-20	transformation related protein 53, pseudogene	Mus musculus	141-144
20303727-0	2011	Involvement of nucleophosmin/B23 in the cellular response to curcumin.	Curcumin	61-69	nucleophosmin 1	Mus musculus	15-28
20303727-0	2011	Involvement of nucleophosmin/B23 in the cellular response to curcumin.	Curcumin	61-69	nucleophosmin 1	Mus musculus	29-32
20303727-2	2011	Herein, we studied the molecular mechanism of NPM/B23 induction by curcumin, a natural AP-1 inhibitor with antitumor properties.	Curcumin	67-75	nucleophosmin 1	Mus musculus	46-49
22362715-8	2011	Taken together, our findings suggest that curcumin can suppress the migratory and invasive ability of mouse hepatoma Hca-F cells, and this action is mediated through a novel mechanism involving inactivation of Cav-1 and EGFR signaling pathways.	Curcumin	42-50	epidermal growth factor receptor	Mus musculus	220-224
20303727-2	2011	Herein, we studied the molecular mechanism of NPM/B23 induction by curcumin, a natural AP-1 inhibitor with antitumor properties.	Curcumin	67-75	nucleophosmin 1	Mus musculus	50-53
20303727-3	2011	Exposure to 5-30 muM curcumin significantly and dose-dependently increased the level of NPM/B23 in non-transformed NIH 3T3 cells but not HeLa cells and F9 cells.	Curcumin	21-29	nucleophosmin 1	Mus musculus	88-91
20303727-3	2011	Exposure to 5-30 muM curcumin significantly and dose-dependently increased the level of NPM/B23 in non-transformed NIH 3T3 cells but not HeLa cells and F9 cells.	Curcumin	21-29	nucleophosmin 1	Mus musculus	92-95
21691262-0	2011	A polymeric nanoparticle formulation of curcumin (NanoCurc ) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation.	Curcumin	40-48	C-C motif chemokine ligand 4	Homo sapiens	73-77
21519798-5	2011	CRM1 expression was dramatically inhibited in lung lesions in mice treated with DOX (0+-0) as compared to controls (90+-17, P=0.001), and could be partially reversed after curcumin treatment (47+-21, P=0.028, DOX vs. DOX+curcumin).	Curcumin	172-180	exportin 1	Mus musculus	0-4
21519798-5	2011	CRM1 expression was dramatically inhibited in lung lesions in mice treated with DOX (0+-0) as compared to controls (90+-17, P=0.001), and could be partially reversed after curcumin treatment (47+-21, P=0.028, DOX vs. DOX+curcumin).	Curcumin	221-229	exportin 1	Mus musculus	0-4
32523525-10	2020	Following similar rationale NPs of poly(lactide-co-glycolide)-poly (ethylene glycol) conjugated with curcumin-derivate (PLGA-PEG-B6/Cur) were reported to improve the spatial learning and memory capability of APP/PS1 mice, compared with native curcumin treatment.	Curcumin	243-251	presenilin 1	Mus musculus	212-215
21598989-8	2011	Further, we found that quercetin and curcumin induced growth arrest by inhibition of Skp2, and induced p27 expression in MDA-MB-231 cells.	Curcumin	37-45	interferon alpha inducible protein 27	Homo sapiens	103-106
21663638-10	2011	Curcumin treatment significantly reduced macrophage infiltration in the kidneys of diabetic rats, suppressed the expression of above proinflammatory cytokines and degradation of IkappaBalpha.	Curcumin	0-8	NFKB inhibitor alpha	Rattus norvegicus	178-190
20303727-6	2011	Furthermore, down-regulation of NPM/B23 by transfection with NPM/B23 antisense plasmid enhanced the sensitivity to curcumin-induced cell death and growth inhibition.	Curcumin	115-123	nucleophosmin 1	Mus musculus	32-35
20303727-6	2011	Furthermore, down-regulation of NPM/B23 by transfection with NPM/B23 antisense plasmid enhanced the sensitivity to curcumin-induced cell death and growth inhibition.	Curcumin	115-123	nucleophosmin 1	Mus musculus	36-39
20303727-6	2011	Furthermore, down-regulation of NPM/B23 by transfection with NPM/B23 antisense plasmid enhanced the sensitivity to curcumin-induced cell death and growth inhibition.	Curcumin	115-123	nucleophosmin 1	Mus musculus	61-64
31972553-2	2020	Polyphenols, including curcumin, procyanidin and quercetin etc., have showed great calcification inhibition potential in crosslinking collagen and elastin scaffolds.	Curcumin	23-31	elastin	Bos taurus	147-154
20937289-8	2011	Interestingly, inhibition of CBP/p300 by curcumin prevented HIF-1alpha from inducing the expression of several angiogenic genes.	Curcumin	41-49	hypoxia-inducible factor 1-alpha	Oryctolagus cuniculus	60-70
21343524-8	2011	The post-TBI dietary supplementation of the curcumin derivative normalized levels of BDNF, and its downstream effectors on synaptic plasticity (CREB, synapsin I) and neuronal signaling (CaMKII), as well as levels of oxidative stress-related molecules (SOD, Sir2).	Curcumin	44-52	cAMP responsive element binding protein 1	Rattus norvegicus	144-148
32004976-13	2020	IL-17A, MPO-producing neutrophils, and NF-kappaB p65 expression in lungs of CLP mice decreased significantly after pretreatment with curcumin.	Curcumin	133-141	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	49-52
21501498-8	2011	In in vivo medulloblastoma xenografts, curcumin reduced tumor growth and significantly increased survival in the Smo/Smo transgenic medulloblastoma mouse model.	Curcumin	39-47	smoothened, frizzled class receptor	Mus musculus	113-116
21501498-8	2011	In in vivo medulloblastoma xenografts, curcumin reduced tumor growth and significantly increased survival in the Smo/Smo transgenic medulloblastoma mouse model.	Curcumin	39-47	smoothened, frizzled class receptor	Mus musculus	117-120
21442412-7	2011	Curcumin interacts with specific proteins in adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells, where it suppresses several cellular proteins such as transcription factor NF-kB, STAT-3, Wnt/beta-catenin and activates PPAR-gamma, Nrf2 cell signaling pathway.	Curcumin	0-8	catenin beta 1	Homo sapiens	224-236
20550967-5	2011	In APP(SWE)/PS1( E9) transgenic mice (AD-Tg; n=18) but not in non-Tg wt mice (n=10), retinal Abeta plaques were detected following systemic administration of curcumin, a safe plaque-labeling fluorochrome.	Curcumin	158-166	presenilin 1	Mus musculus	12-15
21858220-5	2011	In addition, the anti-tumor activity of gefitinib was potentiated via curcumin through blocking EGFR activation and inducing apoptosis in gefitinib-resistant NSCLC cell lines; also the combined treatment with curcumin and gefitinib exhibited significant inhibition in the CL1-5, A549 and H1975 xenografts tumor growth in SCID mice through reducing EGFR, c-MET, cyclin D1 expression, and inducing apoptosis activation through caspases-8, 9 and PARP.	Curcumin	70-78	epidermal growth factor receptor	Mus musculus	96-100
21858220-5	2011	In addition, the anti-tumor activity of gefitinib was potentiated via curcumin through blocking EGFR activation and inducing apoptosis in gefitinib-resistant NSCLC cell lines; also the combined treatment with curcumin and gefitinib exhibited significant inhibition in the CL1-5, A549 and H1975 xenografts tumor growth in SCID mice through reducing EGFR, c-MET, cyclin D1 expression, and inducing apoptosis activation through caspases-8, 9 and PARP.	Curcumin	70-78	epidermal growth factor receptor	Mus musculus	348-352
21858220-5	2011	In addition, the anti-tumor activity of gefitinib was potentiated via curcumin through blocking EGFR activation and inducing apoptosis in gefitinib-resistant NSCLC cell lines; also the combined treatment with curcumin and gefitinib exhibited significant inhibition in the CL1-5, A549 and H1975 xenografts tumor growth in SCID mice through reducing EGFR, c-MET, cyclin D1 expression, and inducing apoptosis activation through caspases-8, 9 and PARP.	Curcumin	70-78	met proto-oncogene	Mus musculus	354-359
21858220-5	2011	In addition, the anti-tumor activity of gefitinib was potentiated via curcumin through blocking EGFR activation and inducing apoptosis in gefitinib-resistant NSCLC cell lines; also the combined treatment with curcumin and gefitinib exhibited significant inhibition in the CL1-5, A549 and H1975 xenografts tumor growth in SCID mice through reducing EGFR, c-MET, cyclin D1 expression, and inducing apoptosis activation through caspases-8, 9 and PARP.	Curcumin	70-78	caspase 8	Mus musculus	425-438
21236599-8	2011	Consequently, curcumin significantly inhibited IR-induced TA and hTERT mRNA at all points investigated.	Curcumin	14-22	telomerase reverse transcriptase	Homo sapiens	65-70
21236599-12	2011	Significantly, curcumin inhibited IR-induced TERT transcription.	Curcumin	15-23	telomerase reverse transcriptase	Homo sapiens	45-49
21236599-13	2011	Consequently, curcumin inhibited hTERT mRNA and TA in NFkappaB overexpressed cells.	Curcumin	14-22	telomerase reverse transcriptase	Homo sapiens	33-38
21437112-2	2010	Curcumin has been reviewed for its multiple molecular action on inhibiting tumor angiogenesis via its mechanisms of cyclooxygenase (COX)-2, and vascular endothelial growth factor (VEGF) inhibition.	Curcumin	0-8	vascular endothelial growth factor A	Rattus norvegicus	144-178
21437112-2	2010	Curcumin has been reviewed for its multiple molecular action on inhibiting tumor angiogenesis via its mechanisms of cyclooxygenase (COX)-2, and vascular endothelial growth factor (VEGF) inhibition.	Curcumin	0-8	vascular endothelial growth factor A	Rattus norvegicus	180-184
21204771-5	2010	HL-60 cells underwent apoptosis on treatment with curcumin, as indicated by increased annexin V-binding capacity and caspase-3 activation with flow cytometric analysis.	Curcumin	50-58	annexin A5	Homo sapiens	86-95
21332098-6	2011	Our results indicated that curcumin suppressed the 8-hydroxy-20-deoxyguanosine level and OGG1 expression, which were increased by arsenic.	Curcumin	27-35	8-oxoguanine DNA glycosylase	Homo sapiens	89-93
32004976-19	2020	CONCLUSIONS: Curcumin can reduce the degree of severity of ALI and uncontrolled inflammation through promoting the differentiation of naive CD4 + T cells to CD4+ CD25+ FOXP3+ Tregs.	Curcumin	13-21	forkhead box P3	Mus musculus	168-173
32073198-7	2020	Curcumin increased tube formation, and messenger RNA (mRNA) expression of angiogenic factors such as vascular endothelial growth factor A (VEGFA) and protein expression of proangiogenic factor VEGF receptor-2 and fatty acid-binding protein-4 (FABP4) in these cells.	Curcumin	0-8	fatty acid binding protein 4	Homo sapiens	213-241
21310849-7	2011	Two known active compounds (curcumin and simvastatin) inhibiting TF activity were tested by the simplified assay to validate the screening method.	Curcumin	28-36	coagulation factor III, tissue factor	Homo sapiens	65-67
19730790-0	2010	Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/beta-catenin antagonists against human osteosarcoma cells.	Curcumin	41-49	catenin beta 1	Homo sapiens	73-85
21485083-0	2011	[Effect of curcumin on the learning, memory and hippocampal Ca+/CaMK II level in senescence-accelerated mice].	Curcumin	11-19	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	64-71
32073198-7	2020	Curcumin increased tube formation, and messenger RNA (mRNA) expression of angiogenic factors such as vascular endothelial growth factor A (VEGFA) and protein expression of proangiogenic factor VEGF receptor-2 and fatty acid-binding protein-4 (FABP4) in these cells.	Curcumin	0-8	fatty acid binding protein 4	Homo sapiens	243-248
21485083-9	2011	The hippocampal [Ca2+]i was markedly lowered, the expression of CaMK II in the hippocampal membrane and the level of hippocampal CaM mRNA obviously increased in the SAMP8 + low, middle and high dose curcumin groups (P &lt; 0.05, P &lt; 0.01).	Curcumin	199-207	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	64-71
21485083-10	2011	CONCLUSION: Curcumin could improve learning and memory Ca2+/capacities of SAM by lowering hippocampal [Ca2+] overload, increase the hippocampal CaM mRNA level and CaMK II expression in the hippocampal dose-dependently.	Curcumin	12-20	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	163-170
19730790-2	2010	In this study, we tested the hypothesis that osteosarcoma progression may be delayed by disrupting the Wnt/beta-catenin pathway using small molecule inhibitors such as curcumin and PKF118-310.	Curcumin	168-176	catenin beta 1	Homo sapiens	107-119
19730790-3	2010	Effective inhibitions of the Wnt/beta-catenin pathway by curcumin and PKF118-310 in osteosarcoma cells were shown by the suppression of both intrinsic and activated beta-catenin/Tcf transcriptional activities using luciferase reporter assays.	Curcumin	57-65	catenin beta 1	Homo sapiens	33-45
19730790-3	2010	Effective inhibitions of the Wnt/beta-catenin pathway by curcumin and PKF118-310 in osteosarcoma cells were shown by the suppression of both intrinsic and activated beta-catenin/Tcf transcriptional activities using luciferase reporter assays.	Curcumin	57-65	catenin beta 1	Homo sapiens	165-177
19730790-6	2010	Overexpression of the wild-type beta-catenin plasmid in osteosarcoma cells resulted in enhanced cell invasiveness but this effect was significantly overcome by curcumin.	Curcumin	160-168	catenin beta 1	Homo sapiens	32-44
21134073-1	2011	Recently, we reported that combined ingestion of soy isoflavones and curcumin significantly decreased the serum level of prostate-specific antigen based on a randomized placebo-controlled double-blind clinical study.	Curcumin	69-77	kallikrein related peptidase 3	Homo sapiens	121-146
21134073-3	2011	The effects of isoflavones and curcumin on the expression and phosphorylation of ataxia-telangiectasia-mutated kinase (ATM), histone H2AX variant (H2AX) and checkpoint kinase2 (Chk2) were examined in LNCaP cells.	Curcumin	31-39	ATM serine/threonine kinase	Homo sapiens	81-117
19730790-7	2010	Gelatin zymography and Western blotting showed that reduced cell invasion with curcumin and PKF118-310 treatment correlated with the activity and protein level of matrix metalloproteinase-9 under conditions of intrinsic or extrinsic Wnt/beta-catenin activation.	Curcumin	79-87	catenin beta 1	Homo sapiens	237-249
32073198-8	2020	Curcumin-stimulated tube formation was associated with an increased expression of VEGFR2 and FABP4.	Curcumin	0-8	fatty acid binding protein 4	Homo sapiens	93-98
20680030-0	2010	Curcumin interrupts the interaction between the androgen receptor and Wnt/beta-catenin signaling pathway in LNCaP prostate cancer cells.	Curcumin	0-8	catenin beta 1	Homo sapiens	74-86
20680030-5	2010	In this study, whether curcumin mediates the Wnt/beta-catenin signaling pathway with regard to AR/beta-catenin interactions was studied.	Curcumin	23-31	catenin beta 1	Homo sapiens	49-61
20629184-6	2011	RESULTS: Curcumin attenuated lipopolysaccharide (LPS)-stimulated expression and secretion of macrophage inflammatory protein (MIP)-2, interleukin (IL)-1beta, keratinocyte chemoattractant (KC), and MIP-1alpha in colonic epithelial cells (CECs) and in macrophages.	Curcumin	9-17	C-X-C motif chemokine ligand 2	Homo sapiens	93-132
20629184-6	2011	RESULTS: Curcumin attenuated lipopolysaccharide (LPS)-stimulated expression and secretion of macrophage inflammatory protein (MIP)-2, interleukin (IL)-1beta, keratinocyte chemoattractant (KC), and MIP-1alpha in colonic epithelial cells (CECs) and in macrophages.	Curcumin	9-17	C-C motif chemokine ligand 3	Homo sapiens	197-207
20629184-7	2011	Curcumin significantly inhibited PMN chemotaxis against MIP-2, KC, or against conditioned media from LPS-treated macrophages or CEC, a well as the IL-8-mediated chemotaxis of human neutrophils.	Curcumin	0-8	C-X-C motif chemokine ligand 2	Homo sapiens	56-61
20680030-5	2010	In this study, whether curcumin mediates the Wnt/beta-catenin signaling pathway with regard to AR/beta-catenin interactions was studied.	Curcumin	23-31	catenin beta 1	Homo sapiens	98-110
20680030-7	2010	Marked curcumin-induced suppression of beta-catenin was shown in the nuclear and cytoplasmic extracts as well as whole cell lysates.	Curcumin	7-15	catenin beta 1	Homo sapiens	39-51
20680030-8	2010	Further analysis revealed that phosphorylation of Akt and glycogen synthase kinase-3beta were attenuated, but phosphorylated beta-catenin was increased after curcumin treatment.	Curcumin	158-166	catenin beta 1	Homo sapiens	125-137
20637579-0	2011	Curcumin improves bone microarchitecture and enhances mineral density in APP/PS1 transgenic mice.	Curcumin	0-8	presenilin 1	Mus musculus	77-80
32073198-9	2020	The stimulatory effects of curcumin were inhibited by VEGFR2 (SU5416) and FABP4 (BMS309403) inhibitors.	Curcumin	27-35	fatty acid binding protein 4	Homo sapiens	74-79
20680030-10	2010	These findings suggest that curcumin modulates the Wnt/beta-catenin signaling pathway and might have a significant role in mediating inhibitory effects on LNCaP prostate cancer cells.	Curcumin	28-36	catenin beta 1	Homo sapiens	55-67
20878089-10	2010	Curcumin induced the unfolding protein response by down-regulating the protein expressions of Calnexin, PDI and Ero1-Lalpha and up-regulating the Calreticulin expression.	Curcumin	0-8	peptidyl arginine deiminase 1	Homo sapiens	104-107
20521051-8	2010	Curcumin itself promotes pro-apoptosis protein Caspase 3 and Caspase 9 cleavage and anti-apoptosis protein Bcl-XL and X-IAP degradation, and combination of C6 ceramide with curcumin dramatically enhances it.	Curcumin	0-8	caspase 9	Homo sapiens	61-70
20934487-3	2011	Inducible expression of miRNA-146a was found to be significantly up-regulated in a primary co-culture of human neuronal-glial (HNG) cells stressed using interleukin1-beta (IL-1beta), and this up-regulation was quenched using specific NF-kB inhibitors including curcumin.	Curcumin	261-269	microRNA 146a	Homo sapiens	24-34
20934487-3	2011	Inducible expression of miRNA-146a was found to be significantly up-regulated in a primary co-culture of human neuronal-glial (HNG) cells stressed using interleukin1-beta (IL-1beta), and this up-regulation was quenched using specific NF-kB inhibitors including curcumin.	Curcumin	261-269	interleukin 1 alpha	Homo sapiens	172-180
20851099-11	2011	Functional assays indicated that the LDLr-binding ability of curcumin-containing HDL with apoE3-NT is similar to that of HDL without curcumin.	Curcumin	61-69	low density lipoprotein receptor	Homo sapiens	37-41
20303727-6	2011	Furthermore, down-regulation of NPM/B23 by transfection with NPM/B23 antisense plasmid enhanced the sensitivity to curcumin-induced cell death and growth inhibition.	Curcumin	115-123	nucleophosmin 1	Mus musculus	65-68
32073198-11	2020	Curcumin increased mRNA expression of DNMT3A and NOTCH signaling system whereas down-regulated mRNA expression of HSD11beta2.	Curcumin	0-8	DNA methyltransferase 3 alpha	Homo sapiens	38-44
20303727-7	2011	These results indicated that NPM/B23 expression regulates cellular sensitivity to curcumin.	Curcumin	82-90	nucleophosmin 1	Mus musculus	29-32
20303727-7	2011	These results indicated that NPM/B23 expression regulates cellular sensitivity to curcumin.	Curcumin	82-90	nucleophosmin 1	Mus musculus	33-36
32171585-0	2020	Corrigendum to "Biochemical and biophysical characterization of curcumin binding to human mitotic kinesin Eg5: Insights into the inhibitory mechanism of curcumin on Eg5" [Int.	Curcumin	64-72	kinesin family member 11	Homo sapiens	165-168
20303727-8	2011	Besides, NPM/B23 knockdown may facilitate as a novel strategy to promote the sensitivity of cancer cells to curcumin.	Curcumin	108-116	nucleophosmin 1	Mus musculus	9-12
20303727-8	2011	Besides, NPM/B23 knockdown may facilitate as a novel strategy to promote the sensitivity of cancer cells to curcumin.	Curcumin	108-116	nucleophosmin 1	Mus musculus	13-16
32171585-0	2020	Corrigendum to "Biochemical and biophysical characterization of curcumin binding to human mitotic kinesin Eg5: Insights into the inhibitory mechanism of curcumin on Eg5" [Int.	Curcumin	153-161	kinesin family member 11	Homo sapiens	106-109
21858220-8	2011	CONCLUSIONS/SIGNIFICANCE: Curcumin potentiates antitumor activity of gefitinib in cell lines and xenograft mice model of NSCLC through inhibition of proliferation, EGFR phosphorylation, and induction EGFR ubiquitination and apoptosis.	Curcumin	26-34	epidermal growth factor receptor	Mus musculus	164-168
32171585-0	2020	Corrigendum to "Biochemical and biophysical characterization of curcumin binding to human mitotic kinesin Eg5: Insights into the inhibitory mechanism of curcumin on Eg5" [Int.	Curcumin	153-161	kinesin family member 11	Homo sapiens	165-168
21858220-8	2011	CONCLUSIONS/SIGNIFICANCE: Curcumin potentiates antitumor activity of gefitinib in cell lines and xenograft mice model of NSCLC through inhibition of proliferation, EGFR phosphorylation, and induction EGFR ubiquitination and apoptosis.	Curcumin	26-34	epidermal growth factor receptor	Mus musculus	200-204
32069075-2	2020	In this study, we established hypoxia-reoxygenation in neonate rat myocardial cells and employed gamma-secretase inhibitor and curcumin to inhibit and activate the Notch1 and Keap1-Nrf2 signaling pathways, respectively.	Curcumin	127-135	notch receptor 1	Rattus norvegicus	164-170
21738619-0	2011	Rescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation.	Curcumin	40-48	rhodopsin	Rattus norvegicus	78-87
20645870-6	2010	Curcumin also modulated the expression of several aging-related genes, including mth, thor, InR, and JNK.	Curcumin	0-8	basket	Drosophila melanogaster	101-104
20885979-8	2010	We found Curcumin decreased the levels of D-lactate, DAO, MPO, ICAM-1, IL-1beta and TNF-alpha, but increased the levels of IL-10 and SOD in rat models.	Curcumin	9-17	myeloperoxidase	Rattus norvegicus	58-61
20885979-8	2010	We found Curcumin decreased the levels of D-lactate, DAO, MPO, ICAM-1, IL-1beta and TNF-alpha, but increased the levels of IL-10 and SOD in rat models.	Curcumin	9-17	interleukin 10	Rattus norvegicus	123-128
20885979-12	2010	CONCLUSIONS/SIGNIFICANCE: The effect of curcumin is mediated by the MKP-1-dependent inactivation of p38 and inhibition of NF-kappaB-mediated transcription.	Curcumin	40-48	dual specificity phosphatase 1	Rattus norvegicus	68-73
21738619-5	2011	In this study we present that treatment of COS-7 cells expressing mutant rhodopsin with curcumin results in dissociation of mutant protein aggregates and decreases endoplasmic reticulum stress.	Curcumin	88-96	rhodopsin	Rattus norvegicus	73-82
21738619-6	2011	Furthermore we demonstrate that administration of curcumin to P23H-rhodopsin transgenic rats improves retinal morphology, physiology, gene expression and localization of rhodopsin.	Curcumin	50-58	rhodopsin	Rattus norvegicus	67-76
20430097-1	2010	We have identified a novel anti-inflammatory signaling pathway that leads to the expression of heme oxygenase-1 (HO-1) in response to bisdemethoxycurcumin (BDMC), an analog of curcumin.	Curcumin	146-154	heme oxygenase 1	Homo sapiens	95-111
21738619-6	2011	Furthermore we demonstrate that administration of curcumin to P23H-rhodopsin transgenic rats improves retinal morphology, physiology, gene expression and localization of rhodopsin.	Curcumin	50-58	rhodopsin	Rattus norvegicus	170-179
31962379-2	2020	Total plasma concentration of curcumin is often quantified after treatment with beta-glucuronidase to hydrolyze curcumin-glucuronide, the most abundant conjugate in vivo.	Curcumin	30-38	glucuronidase, beta	Mus musculus	80-98
21738619-7	2011	Our findings indicate that supplementation of curcumin improves retinal structure and function in P23H-rhodopsin transgenic rats.	Curcumin	46-54	rhodopsin	Rattus norvegicus	103-112
21738619-8	2011	This data also suggest that curcumin may serve as a potential therapeutic agent in treating RP due to the P23H rhodopsin mutation and perhaps other degenerative diseases caused by protein trafficking defects.	Curcumin	28-36	rhodopsin	Rattus norvegicus	111-120
20430097-1	2010	We have identified a novel anti-inflammatory signaling pathway that leads to the expression of heme oxygenase-1 (HO-1) in response to bisdemethoxycurcumin (BDMC), an analog of curcumin.	Curcumin	146-154	heme oxygenase 1	Homo sapiens	113-117
20596601-10	2010	In the core signaling pathways of glioblastoma, curcumin either significantly influences the p53 pathway by enhancing p53 and p21 and suppressing cdc2 or significantly inhibits the RB pathway by enhancing CDKN2A/p16 and suppressing phosphorylated RB.	Curcumin	48-56	H3 histone pseudogene 16	Homo sapiens	126-129
20596601-10	2010	In the core signaling pathways of glioblastoma, curcumin either significantly influences the p53 pathway by enhancing p53 and p21 and suppressing cdc2 or significantly inhibits the RB pathway by enhancing CDKN2A/p16 and suppressing phosphorylated RB.	Curcumin	48-56	cyclin dependent kinase 1	Homo sapiens	146-150
31962379-4	2020	METHODS AND RESULTS: Using liquid chromatography-mass spectrometry (LC-MS) analyses the efficiency of beta-glucuronidase and sulfatase from Helix pomatia is compared to hydrolyze curcumin conjugates in human and mouse plasma after oral administration of turmeric.	Curcumin	179-187	glucuronidase, beta	Mus musculus	102-120
20514428-3	2010	Curcumin suppressed the cellular melanin contents and the tyrosinase activity in alpha-MSH-stimulated B16F10 cells.	Curcumin	0-8	tyrosinase	Mus musculus	58-68
20514428-4	2010	In addition, the expression of melanogenesis-related proteins such as microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein 1 and 2 was suppressed by curcumin in the alpha-MSH-stimulated B16F10 cells.	Curcumin	194-202	tyrosinase	Mus musculus	125-135
20514428-5	2010	Notably, a melanogenesis-regulating signal such as mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) or phosphatidylinositol 3-kinase (PI3K)/Akt was activated by curcumin in the B16F10 cells treated with or without alpha-MSH.	Curcumin	202-210	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	144-173
21434326-1	2011	OBJECTIVE: To investigate the reversion of P-gp mediated multidrug resistance of U-2OS/ADM cells with curcumin in vitro.	Curcumin	102-110	phosphoglycolate phosphatase	Homo sapiens	43-47
21434326-6	2011	CONCLUSION: The reversal mechanism of curcumin was blocked the function of P-gp in U-2OS/ADM cellular membrane.	Curcumin	38-46	phosphoglycolate phosphatase	Homo sapiens	75-79
31962379-6	2020	Unexpectedly, beta-glucuronidase hydrolysis is incomplete, affording a large amount of curcumin-sulfate, whereas sulfatase hydrolyzed both glucuronide and sulfate conjugates.	Curcumin	87-103	glucuronidase, beta	Mus musculus	14-32
31962379-10	2020	CONCLUSION: beta-Glucuronidase incompletely hydrolyzes complex sulfate-containing conjugates that appear to be major metabolites, resulting in an underestimation of the total plasma concentration of curcumin.	Curcumin	199-207	glucuronidase, beta	Mus musculus	12-30
32020216-8	2020	Curcumin-induced hypomethylation of the BRCA1 promoter appears to be realized through the upregulation of the ten-eleven translocation 1 (TET1) gene, whereas curcumin-induced hypermethylation of SNCG may be realized through the upregulation of the DNA methyltransferase 3 (DNMT3) and the downregulation of TET1.	Curcumin	0-8	tet methylcytosine dioxygenase 1	Homo sapiens	110-136
21070208-13	2010	Curcumin arrests maturation of DC and induces a tolerogenic phenotype that subsequently promotes functional FoxP3(+) T(regs) in vitro and in vivo.	Curcumin	0-8	forkhead box P3	Mus musculus	108-113
32020216-8	2020	Curcumin-induced hypomethylation of the BRCA1 promoter appears to be realized through the upregulation of the ten-eleven translocation 1 (TET1) gene, whereas curcumin-induced hypermethylation of SNCG may be realized through the upregulation of the DNA methyltransferase 3 (DNMT3) and the downregulation of TET1.	Curcumin	0-8	tet methylcytosine dioxygenase 1	Homo sapiens	138-142
32020216-8	2020	Curcumin-induced hypomethylation of the BRCA1 promoter appears to be realized through the upregulation of the ten-eleven translocation 1 (TET1) gene, whereas curcumin-induced hypermethylation of SNCG may be realized through the upregulation of the DNA methyltransferase 3 (DNMT3) and the downregulation of TET1.	Curcumin	0-8	tet methylcytosine dioxygenase 1	Homo sapiens	306-310
20484172-3	2010	OBJECTIVE: To investigate the effect of curcumin on the activities of CYP1A2, CYP2A6, N-acetyltransferase (NAT2), and xanthine oxidase (XO) in vivo, using caffeine as a probe drug.	Curcumin	40-48	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	70-76
32020216-8	2020	Curcumin-induced hypomethylation of the BRCA1 promoter appears to be realized through the upregulation of the ten-eleven translocation 1 (TET1) gene, whereas curcumin-induced hypermethylation of SNCG may be realized through the upregulation of the DNA methyltransferase 3 (DNMT3) and the downregulation of TET1.	Curcumin	158-166	tet methylcytosine dioxygenase 1	Homo sapiens	306-310
20813175-4	2010	Curcumin nanoparticles demonstrate comparable in vitro therapeutic efficacy to free curcumin against a panel of human hepatocellular cancer cell lines, as assessed by cell viability (3-[4,5-dimethylthiazol-2-yl]2,5-diphenyltetrazolium bromide assay [MTT assay]) and proapoptotic effects (annexin V/propidium iodide staining).	Curcumin	0-8	annexin A5	Homo sapiens	288-297
32020216-9	2020	Notably, miR-29b was found to be reversely expressed compared to TET1 in curcumin- and 5"-aza-CdR-treated cells, suggesting its involvement in the regulation of TET1.	Curcumin	73-81	tet methylcytosine dioxygenase 1	Homo sapiens	65-69
20878089-11	2010	Curcumin induces the GADD153 expression by cleaving caspase-12 and ATF6, and then by translocating ATF6 to the nucleus.	Curcumin	0-8	activating transcription factor 6	Homo sapiens	67-71
32020216-9	2020	Notably, miR-29b was found to be reversely expressed compared to TET1 in curcumin- and 5"-aza-CdR-treated cells, suggesting its involvement in the regulation of TET1.	Curcumin	73-81	tet methylcytosine dioxygenase 1	Homo sapiens	161-165
20878089-11	2010	Curcumin induces the GADD153 expression by cleaving caspase-12 and ATF6, and then by translocating ATF6 to the nucleus.	Curcumin	0-8	activating transcription factor 6	Homo sapiens	99-103
20878089-12	2010	Curcumin also down-regulates the protein expressions of TCTP, Mcl-1 and Bcl-2, in order to induce mitochondrial dysfunction.	Curcumin	0-8	tumor protein, translationally-controlled 1	Homo sapiens	56-60
32027482-3	2020	The curcumin analog-based nanoscavenger (NanoCA) is engineered capable of controlled-release property to stimulate nuclear translocation of the major autophagy regulator, transcription factor EB (TFEB), triggering both autophagy and calcium-dependent exosome secretion for the clearance of alpha-syn.	Curcumin	4-12	synuclein, alpha	Mus musculus	290-299
20878089-12	2010	Curcumin also down-regulates the protein expressions of TCTP, Mcl-1 and Bcl-2, in order to induce mitochondrial dysfunction.	Curcumin	0-8	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	62-67
20878089-13	2010	Curcumin induced cell cycle arrest at the G2/M phase by decreasing the Cdc2 expression.	Curcumin	0-8	cyclin dependent kinase 1	Homo sapiens	71-75
21472350-5	2010	Curcumin, a nuclear factor-kappaB (NF-kappaB) inhibitor, increased the sensitivity to irinotecan of A549/CTP-11R cells.	Curcumin	0-8	SPANX family member C	Homo sapiens	105-111
19879740-7	2010	However, calcein-AM uptake into the human P-gp overexpression cell line, LLC-GA5-COL300, was increased by curcumin and demethoxycurcumin in a concentration-dependent manner but not affected by bisdemethoxycurcumin.	Curcumin	106-114	phosphoglycolate phosphatase	Homo sapiens	42-46
19879740-8	2010	These results show that curcumin and demethoxycurcumin could inhibit P-gp but bisdemethoxycurcumin may modulate the function of other efflux transporters such as MRP.	Curcumin	24-32	phosphoglycolate phosphatase	Homo sapiens	69-73
20222050-7	2010	Thus, improvement of insulin and leptin signaling transduction and subsequently elevation of peroxisome proliferator-activated receptor alpha expression by curcumin led to reduction of very-low-density lipoprotein overproduction and triglyceride hypersynthesis.	Curcumin	156-164	peroxisome proliferator activated receptor alpha	Rattus norvegicus	93-141
20508869-6	2010	Oral supplementation of curcumin at a dose of 2 g/kg for 30 days resulted in a transient decrease in MDA, catalase and GST levels in the rat cerebrum and cerebellum.	Curcumin	24-32	hematopoietic prostaglandin D synthase	Rattus norvegicus	119-122
21036715-4	2010	RESULTS: Curcumin significantly caused radiation induced expression of p21 and Bax, and reduced BclXl, Mcl1 with only marginal Bcl2 modulation.	Curcumin	9-17	H3 histone pseudogene 16	Homo sapiens	71-74
21036715-4	2010	RESULTS: Curcumin significantly caused radiation induced expression of p21 and Bax, and reduced BclXl, Mcl1 with only marginal Bcl2 modulation.	Curcumin	9-17	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	103-107
20840775-9	2010	Simultaneously, levels of the biologically active phospho-STAT3 were decreased and correlated with reduced transcription of the cell cycle regulating gene c-Myc and proliferation marking Ki-67, pointing to a potential mechanism by which Curcumin slows tumor growth.	Curcumin	237-245	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	155-160
20433710-0	2010	Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson"s disease cell model.	Curcumin	0-8	synuclein alpha	Homo sapiens	17-32
31659616-5	2020	We have been able to demonstrate that curcumin significantly increases oxidative stress and accelerates replicative and chronological aging of yeast cells devoid of anti-oxidative protection (with SOD1 and SOD2 gene deletion) and deprived of DNA repair mechanisms (RAD52).	Curcumin	38-46	recombinase RAD52	Saccharomyces cerevisiae S288C	265-270
31816386-9	2020	On the other hand, we also found that the protective function of curcumin was diminished when PRKAA1 was depleted in IPEC-J2 cells treated with H2O2.	Curcumin	65-73	PRKAA1	Sus scrofa	94-100
31656219-8	2020	Also, the expression of GDF-9, BMP-15, SIRT-1 and SIRT-3 genes was increased in the curcumin group.	Curcumin	84-92	growth differentiation factor 9	Mus musculus	24-29
20429876-7	2010	The effect of curcumin pre-treatment on the expression of apoptosis related proteins and beta-catenin was determined by Western blotting or Flow Cytometry.	Curcumin	14-22	catenin beta 1	Homo sapiens	89-101
20429876-8	2010	A luciferase reporter assay was used to determine the effect of curcumin on beta-catenin transcription activity.	Curcumin	64-72	catenin beta 1	Homo sapiens	76-88
20429876-11	2010	During the 6 hr pre-treatment, curcumin down regulated the expression of Bcl-XL and Mcl-1 pro-survival proteins.	Curcumin	31-39	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	84-89
20429876-12	2010	Curcumin pre-treatment followed by exposure to low doses of cisplatin increased apoptosis as indicated by annexin V staining and cleavage of caspase 9 and PARP.	Curcumin	0-8	annexin A5	Homo sapiens	106-115
20429876-12	2010	Curcumin pre-treatment followed by exposure to low doses of cisplatin increased apoptosis as indicated by annexin V staining and cleavage of caspase 9 and PARP.	Curcumin	0-8	caspase 9	Homo sapiens	141-150
20503397-0	2010	Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen.	Curcumin	51-59	kallikrein related peptidase 3	Homo sapiens	81-106
20503397-5	2010	After that, we conducted a clinical trial for men who received prostate biopsies, but were not found to have prostate cancer, to evaluate the effects of soy isoflavones and curcumin on serum PSA levels.	Curcumin	173-181	kallikrein related peptidase 3	Homo sapiens	191-194
20503397-10	2010	RESULTS: The production of PSA were markedly decreased by the combined treatment of isoflavones and curcumin in prostate cancer cell line, LNCaP.	Curcumin	100-108	kallikrein related peptidase 3	Homo sapiens	27-30
20503397-12	2010	In clinical trials, PSA levels decreased in the patients group with PSA &gt;or= 10 treated with supplement containing isoflavones and curcumin (P = 0.01).	Curcumin	134-142	kallikrein related peptidase 3	Homo sapiens	20-23
20503397-12	2010	In clinical trials, PSA levels decreased in the patients group with PSA &gt;or= 10 treated with supplement containing isoflavones and curcumin (P = 0.01).	Curcumin	134-142	kallikrein related peptidase 3	Homo sapiens	68-71
20503397-13	2010	CONCLUSIONS: Our results indicated that isoflavones and curcumin could modulate serum PSA levels.	Curcumin	56-64	kallikrein related peptidase 3	Homo sapiens	86-89
20503397-14	2010	Curcumin presumably synergizes with isoflavones to suppress PSA production in prostate cells through the anti-androgen effects.	Curcumin	0-8	kallikrein related peptidase 3	Homo sapiens	60-63
20429876-13	2010	Additionally, curcumin pre-treatment lowered beta-catenin expression and transcriptional activity.	Curcumin	14-22	catenin beta 1	Homo sapiens	45-57
20346917-6	2010	On the other hand, immunoblot analysis revealed that co-treatment with RA and curcumin caused remarkable accumulation of protein levels of p47-phox (to 7-fold) and p67-phox (to 4-fold) compared with those of the RA-treatment alone.	Curcumin	78-86	pleckstrin	Homo sapiens	139-142
20484172-10	2010	RESULTS: In the curcumin-treated group, CYP1A2 activity was decreased by 28.6% (95% CI 15.6 to 41.8; p &lt; 0.000), while increases were observed in CYP2A6 (by 48.9%; 95% CI 25.3 to 72.4; p &lt; 0.000).	Curcumin	16-24	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	40-46
31656219-8	2020	Also, the expression of GDF-9, BMP-15, SIRT-1 and SIRT-3 genes was increased in the curcumin group.	Curcumin	84-92	sirtuin 1	Mus musculus	39-45
20484172-15	2010	CONCLUSIONS: The results indicated that curcumin inhibits CYP1A2 function but enhances CYP2A6 activity.	Curcumin	40-48	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	58-64
31656219-8	2020	Also, the expression of GDF-9, BMP-15, SIRT-1 and SIRT-3 genes was increased in the curcumin group.	Curcumin	84-92	sirtuin 3	Mus musculus	50-56
33329788-7	2020	Neutrophil apoptosis was also measured by fluorescence-activated cell sorting (annexin V/propidium iodide) in LPS-stimulated neutrophils under treatment with curcumin.	Curcumin	158-166	annexin A5	Homo sapiens	79-88
20513244-0	2010	Curcumin modulates dopaminergic receptor, CREB and phospholipase C gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats.	Curcumin	0-8	cAMP responsive element binding protein 1	Rattus norvegicus	42-46
20513244-2	2010	This study aims at evaluating the effect of curcumin in modulating the altered dopaminergic receptors, CREB and phospholipase C in the cerebral cortex and cerebellum of STZ induced diabetic rats.	Curcumin	44-52	cAMP responsive element binding protein 1	Rattus norvegicus	103-107
20133951-9	2010	However, Caco-2 cells treated with anti-IGF-II-antibodies were rendered sensitive to inhibitory effects of curcumin.	Curcumin	107-115	insulin like growth factor 2	Homo sapiens	40-46
20133951-12	2010	Treatment with a p38MAPK inhibitor resulted in loss of protective effects of IGF-II against inhibitory effects of curcumin.	Curcumin	114-122	insulin like growth factor 2	Homo sapiens	77-83
20332524-6	2010	Moreover, curcumin inhibited cholangiocyte proliferation and expression of activation marker vascular cell adhesion molecule-1 in Mdr2(-/-) mice.	Curcumin	10-18	vascular cell adhesion molecule 1	Mus musculus	93-126
20513244-8	2010	We report that curcumin supplementation reduces diabetes induced alteration of dopamine D1, D2 receptors, transcription factor CREB and phospholipase C to near control.	Curcumin	15-23	cAMP responsive element binding protein 1	Rattus norvegicus	127-131
32024036-4	2020	In gastrocnemius of unloaded and reloaded mice treated with curcumin, proteolytic and signaling markers (NF-kB p50) decreased and sirtuin-1 activity and hybrid fibers size increased (reloaded muscle), while no significant improvement was seen in muscle function.	Curcumin	60-68	sirtuin 1	Mus musculus	130-139
20513244-9	2010	Our results indicate that curcumin has a potential to regulate diabetes induced malfunctions of dopaminergic signalling, CREB and Phospholipase C expression in cerebral cortex and cerebellum and thereby improving the cognitive and emotional functions associated with these regions.	Curcumin	26-34	cAMP responsive element binding protein 1	Rattus norvegicus	121-125
20513244-10	2010	Furthermore, in line with these studies an interaction between curcumin and dopaminergic receptors, CREB and phospholipase C is suggested, which attenuates the cortical and cerebellar dysfunction in diabetes.	Curcumin	63-71	cAMP responsive element binding protein 1	Rattus norvegicus	100-104
20388782-0	2010	Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF.	Curcumin	121-129	microRNA 21	Homo sapiens	100-106
20388782-2	2010	We have previously evaluated the bioavailability of novel analogues of curcumin compared with curcumin, and we found that the analogue CDF exhibited greater systemic and pancreatic tissue bioavailability.	Curcumin	71-79	LIF interleukin 6 family cytokine	Homo sapiens	135-138
20388782-2	2010	We have previously evaluated the bioavailability of novel analogues of curcumin compared with curcumin, and we found that the analogue CDF exhibited greater systemic and pancreatic tissue bioavailability.	Curcumin	94-102	LIF interleukin 6 family cytokine	Homo sapiens	135-138
20422739-0	2010	Curcumin reduces angiotensin II-mediated cardiomyocyte growth via LOX-1 inhibition.	Curcumin	0-8	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	66-71
20422739-3	2010	We postulated that curcumin may reduce Ang II-mediated cardiomyocyte growth via AT1R and LOX-1 inhibition.	Curcumin	19-27	angiotensin II, type I receptor-associated protein	Mus musculus	80-84
20422739-3	2010	We postulated that curcumin may reduce Ang II-mediated cardiomyocyte growth via AT1R and LOX-1 inhibition.	Curcumin	19-27	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	89-94
20422739-8	2010	Attenuation of redox state by curcumin resulted in abrogation of Ang II-mediated cardiomyocyte growth and atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes.	Curcumin	30-38	natriuretic peptide type B	Mus musculus	143-168
20422739-8	2010	Attenuation of redox state by curcumin resulted in abrogation of Ang II-mediated cardiomyocyte growth and atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes.	Curcumin	30-38	natriuretic peptide type B	Mus musculus	170-173
20422739-9	2010	Curcumin also reduced Ang II-mediated upregulation of AT1R and LOX-1.	Curcumin	0-8	angiotensin II, type I receptor-associated protein	Mus musculus	54-58
20422739-9	2010	Curcumin also reduced Ang II-mediated upregulation of AT1R and LOX-1.	Curcumin	0-8	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	63-68
20422739-10	2010	The forced upregulation of LOX-1 enhanced the expression of genes for AT1R, ANP, and BNP, and curcumin pretreatment reduced LOX-1 and AT1R expression and LOX-1-mediated increase in hypertrophy markers.	Curcumin	94-102	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	27-32
32024036-5	2020	Treatment with curcumin elicited a rise in sirtuin-1 activity, while attenuating proteolysis in gastrocnemius of mice during reloading following a period of unloading.	Curcumin	15-23	sirtuin 1	Mus musculus	43-52
20422739-10	2010	The forced upregulation of LOX-1 enhanced the expression of genes for AT1R, ANP, and BNP, and curcumin pretreatment reduced LOX-1 and AT1R expression and LOX-1-mediated increase in hypertrophy markers.	Curcumin	94-102	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	124-129
20368270-4	2010	Treatment with a p38MAPK inhibitor (SB203580), an ERK inhibitor (PD98059), or an MEK inhibitor (U0126), suppressed the increase in MCP1 expression caused by hypertonic NaCl, whereas a JNK inhibitor (SP600125) and an AP1 inhibitor (curcumin) failed to attenuate MCP1 mRNA expression by NaCl.	Curcumin	231-239	C-C motif chemokine ligand 2	Rattus norvegicus	131-135
20132469-6	2010	Notably, curcumin blocked IL-1beta-induced aquaporin-4 expression in cultured astrocytes, an effect mediated, at least in part, by reduced activation of the p50 and p65 subunits of nuclear factor kappaB.	Curcumin	9-17	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	165-168
20422739-10	2010	The forced upregulation of LOX-1 enhanced the expression of genes for AT1R, ANP, and BNP, and curcumin pretreatment reduced LOX-1 and AT1R expression and LOX-1-mediated increase in hypertrophy markers.	Curcumin	94-102	angiotensin II, type I receptor-associated protein	Mus musculus	134-138
20422739-10	2010	The forced upregulation of LOX-1 enhanced the expression of genes for AT1R, ANP, and BNP, and curcumin pretreatment reduced LOX-1 and AT1R expression and LOX-1-mediated increase in hypertrophy markers.	Curcumin	94-102	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	124-129
20132469-7	2010	Consistent with this notion, curcumin preferentially attenuated phosphorylated p65 immunoreactivity in pericontusional astrocytes and decreased the expression of glial fibrillary acidic protein, a reactive astrocyte marker.	Curcumin	29-37	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	79-82
20422739-11	2010	CONCLUSIONS: Curcumin attenuates Ang II-mediated cardiomyocyte growth by inhibiting LOX-1 and AT1R expression and suppressing the heightened intracellular redox state.	Curcumin	13-21	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	84-89
20132469-7	2010	Consistent with this notion, curcumin preferentially attenuated phosphorylated p65 immunoreactivity in pericontusional astrocytes and decreased the expression of glial fibrillary acidic protein, a reactive astrocyte marker.	Curcumin	29-37	glial fibrillary acidic protein	Mus musculus	162-193
32024036-6	2020	Curcumin attenuated muscle proteolysis probably via activation of histone deacetylase sirtuin-1, which also led to decreased levels of atrophy signaling pathways.	Curcumin	0-8	sirtuin 1	Mus musculus	86-95
20372842-9	2010	Caspases activation during the course of curcumin-induced apoptosis was additionally confirmed by using a broad-spectrum caspases inhibitor, Z-VAD-fmk.	Curcumin	41-49	caspase 9	Homo sapiens	121-129
20422739-11	2010	CONCLUSIONS: Curcumin attenuates Ang II-mediated cardiomyocyte growth by inhibiting LOX-1 and AT1R expression and suppressing the heightened intracellular redox state.	Curcumin	13-21	angiotensin II, type I receptor-associated protein	Mus musculus	94-98
20372842-11	2010	These results suggested that mitochondria played an important role in the curcumin-induced apoptosis, and mitochondria membrane potential loss initiated apoptosis via the activation of caspases.	Curcumin	74-82	caspase 9	Homo sapiens	185-193
32051864-11	2020	In addition, curcumin treatment decreased phosphorylated STAT3 and expression levels of Mcl-1, HDACs and ANGPTL4.	Curcumin	13-21	angiopoietin like 4	Homo sapiens	105-112
20133951-4	2010	IGF-II was significantly more effective than progastrin in reversing antiproliferative effects of curcumin and reversed proapoptotic effects of curcumin by &gt;80%; progastrin was relatively ineffective toward reversing proapoptotic effects of curcumin.	Curcumin	98-106	insulin like growth factor 2	Homo sapiens	0-6
20133951-4	2010	IGF-II was significantly more effective than progastrin in reversing antiproliferative effects of curcumin and reversed proapoptotic effects of curcumin by &gt;80%; progastrin was relatively ineffective toward reversing proapoptotic effects of curcumin.	Curcumin	144-152	insulin like growth factor 2	Homo sapiens	0-6
31799527-5	2020	This system was able to encapsulate curcumin at 80 mug mL-1 with an efficiency of ca.	Curcumin	36-44	L1 cell adhesion molecule	Mus musculus	55-59
20133951-4	2010	IGF-II was significantly more effective than progastrin in reversing antiproliferative effects of curcumin and reversed proapoptotic effects of curcumin by &gt;80%; progastrin was relatively ineffective toward reversing proapoptotic effects of curcumin.	Curcumin	144-152	insulin like growth factor 2	Homo sapiens	0-6
20373902-7	2010	Curcumin significantly increased the level of cytosol cytochrome c (2-fold greater than the controls after 2 hr treatment), caspase-9 and caspase-3 activities (approximately 4.5- and 6-fold greater than the controls after 2-6 hr treatment, respectively) in a dose-dependent manner.	Curcumin	0-8	caspase 9	Homo sapiens	124-133
20373902-9	2010	This effect is associated with the release of cytochrome c from the mitochondria and the activation of caspase-9 and caspase-3 in uveal melanoma cells after treatment with curcumin.	Curcumin	172-180	caspase 9	Homo sapiens	103-112
19777504-2	2010	Here, we found that curcumin inhibited cell proliferation and motility with decreased activities of matrix metalloproteinase (MMP)-2/9 and decreased mRNA expressions of urokinase-type plasminogen activator (uPA) and its receptor uPAR in the highly invasive human YD-10B OSCC cells.	Curcumin	20-28	plasminogen activator, urokinase receptor	Homo sapiens	229-233
20448485-0	2010	Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples.	Curcumin	0-8	microtubule associated protein tau	Homo sapiens	40-43
20448485-1	2010	The study aimed to characterize curcumin (CCM) (fluorescent yellow curry pigment) labeling of neuronal fibrillar tau inclusions (FTIs) in representative cases of 3 main tauopathies: Alzheimer disease (AD), progressive supranuclear palsy, and Pick disease.	Curcumin	32-40	microtubule associated protein tau	Homo sapiens	113-116
20448485-1	2010	The study aimed to characterize curcumin (CCM) (fluorescent yellow curry pigment) labeling of neuronal fibrillar tau inclusions (FTIs) in representative cases of 3 main tauopathies: Alzheimer disease (AD), progressive supranuclear palsy, and Pick disease.	Curcumin	42-45	microtubule associated protein tau	Homo sapiens	113-116
20448485-3	2010	Curcumin preference for specific tau isoforms was tested with 3-repeat tau and 4-repeat tau isoform-specific immunofluorescence.	Curcumin	0-8	microtubule associated protein tau	Homo sapiens	33-36
20448485-3	2010	Curcumin preference for specific tau isoforms was tested with 3-repeat tau and 4-repeat tau isoform-specific immunofluorescence.	Curcumin	0-8	microtubule associated protein tau	Homo sapiens	71-74
20448485-3	2010	Curcumin preference for specific tau isoforms was tested with 3-repeat tau and 4-repeat tau isoform-specific immunofluorescence.	Curcumin	0-8	microtubule associated protein tau	Homo sapiens	71-74
31864780-0	2020	Corrigendum to "Biochemical and Biophysical characterization of curcumin binding to human mitotic kinesin Eg5: Insights into the inhibitory mechanism of curcumin on Eg5" [Int.	Curcumin	153-161	kinesin family member 11	Homo sapiens	106-109
20448485-8	2010	These results provide the basis for potential future applications of CCM binding of tau aggregates in diagnostic pathology and in vivo.	Curcumin	69-72	microtubule associated protein tau	Homo sapiens	84-87
20338103-8	2010	RESULTS: Minimal inhibitory concentration (MIC) of MUC5AC expression of each polyphenol was found as follows: [6]-gingerol, 1 microM; EGCG, 20 microM; quercetin, 40 microM; and curcumin, 10 microM.	Curcumin	177-185	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	51-57
31864780-0	2020	Corrigendum to "Biochemical and Biophysical characterization of curcumin binding to human mitotic kinesin Eg5: Insights into the inhibitory mechanism of curcumin on Eg5" [Int.	Curcumin	153-161	kinesin family member 11	Homo sapiens	165-168
20371885-17	2010	In conclusion, protective effect of curcumin against cyclosporine-induced nephrotoxicity in rats was proven based on the study of histological changes and GST immunoexpression.	Curcumin	36-44	hematopoietic prostaglandin D synthase	Rattus norvegicus	155-158
31628941-4	2020	The present study, therefore, aimed at investigating the effect of both curcumin (CUR) and vitamin D3 (D3) on MDR-1 and ALDH-1 expression and consequently the resistance to PAX both in vitro and in vivo.	Curcumin	72-80	aldehyde dehydrogenase 1 family member A1	Homo sapiens	120-126
19788403-8	2010	On contrary, curcumin increased IFN-gamma, IL-12 and IL-13 levels, but decreased TNF-alpha level in rats.	Curcumin	13-21	interferon gamma	Rattus norvegicus	32-41
19788403-8	2010	On contrary, curcumin increased IFN-gamma, IL-12 and IL-13 levels, but decreased TNF-alpha level in rats.	Curcumin	13-21	interleukin 12B	Rattus norvegicus	43-48
20071071-6	2010	The present work also reveals that bisdemethoxycurcumin binds to GLOI in a similar manner as curcumin and exhibits a slightly less negative predicted binding free energy, which is further validated by our comparative kinetics analysis (Ki=18.2 and 10.3muM for bisdemethoxycurcumin and curcumin, respectively).	Curcumin	47-55	glyoxalase I	Homo sapiens	65-69
31628941-4	2020	The present study, therefore, aimed at investigating the effect of both curcumin (CUR) and vitamin D3 (D3) on MDR-1 and ALDH-1 expression and consequently the resistance to PAX both in vitro and in vivo.	Curcumin	82-85	aldehyde dehydrogenase 1 family member A1	Homo sapiens	120-126
19821784-8	2010	On the contrary, curcumin increased IFN-gamma, IL-12 and IL-13 levels, but decreased TNF-alpha level in rats.	Curcumin	17-25	interferon gamma	Rattus norvegicus	36-45
32673649-12	2020	On the other hand, curcumin decreased JNK and Smad3 phosphorylation.	Curcumin	19-27	mitogen-activated protein kinase 8	Rattus norvegicus	38-41
19821784-8	2010	On the contrary, curcumin increased IFN-gamma, IL-12 and IL-13 levels, but decreased TNF-alpha level in rats.	Curcumin	17-25	interleukin 12B	Rattus norvegicus	47-52
20145018-4	2010	Similarly, cells suppressed for MLH1 or MSH2 expression by RNA interference displayed increased curcumin sensitivity.	Curcumin	96-104	mutL homolog 1	Homo sapiens	32-36
32673649-14	2020	Curcumin normalized GSH, and NF-kappaB, JNK-Smad3, and TGF-beta-Smad3 pathways, leading to a decrement in activated hepatic stellate cells, thereby producing its antifibrotic effects.	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	40-43
20039095-0	2010	The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition.	Curcumin	85-93	heat shock protein 90 alpha family class A member 1	Homo sapiens	109-114
20039095-2	2010	In this study, we observed that curcumin inhibited Hsp90 activity causing depletion of client proteins implicated in survival pathways.	Curcumin	32-40	heat shock protein 90 alpha family class A member 1	Homo sapiens	51-56
20127004-7	2010	Results from Western blotting showed that curcumin inhibited the protein levels of PKC, FAK, NF-kappaB p65 and Rho A leading to the inhibition of ERK1/2, MKK7, COX-2 and ROCK1, respectively, finally causing the inhibition of MMP-2 and -9 for the inhibition of migration and invasion of N18 cells.	Curcumin	42-50	protein tyrosine kinase 2	Rattus norvegicus	88-91
33016914-9	2020	A small human RCT using Theracurmin, a well-absorbed form of curcumin that lowers TNF-alpha, showed enhanced cognitive performance and decreased brain levels of amyloid-beta plaque and tau tangles.	Curcumin	61-69	microtubule associated protein tau	Homo sapiens	185-188
20039095-3	2010	Based on this observation, this study was designed to investigate the cellular effects of curcumin combination with the pan-HDAC inhibitors, vorinostat and panobinostat, which induce hyperacetylation of Hsp90, resulting in inhibition of its chaperone function.	Curcumin	90-98	heat shock protein 90 alpha family class A member 1	Homo sapiens	203-208
20145189-7	2010	In the immortalized, leukoplakia, and cancer cells, curcumin inhibited cap-dependent translation by suppressing the phosphorylation of 4E-BP1, eIF4G, eIF4B, and Mnk1, and also reduced the total levels of eIF4E and Mnk1.	Curcumin	52-60	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	135-141
19944674-7	2010	Curcumin inhibited cell growth, induced apoptosis and upregulated maspin gene expression in MCF-7 cells and these findings were further correlated with the upregulation of p53 protein and downregulation of Bcl-2, suggesting maspin mediated apoptosis in MCF-7 cells.	Curcumin	0-8	serpin family B member 5	Homo sapiens	224-230
19944674-8	2010	To our knowledge this is the first report showing the upregulation of maspin expression by curcumin in breast cancer cells and taken together with the clinical data suggests a potential therapeutic role for curcumin in inducing maspin mediated inhibition of invasion of breast carcinoma cells.	Curcumin	91-99	serpin family B member 5	Homo sapiens	70-76
19944674-8	2010	To our knowledge this is the first report showing the upregulation of maspin expression by curcumin in breast cancer cells and taken together with the clinical data suggests a potential therapeutic role for curcumin in inducing maspin mediated inhibition of invasion of breast carcinoma cells.	Curcumin	207-215	serpin family B member 5	Homo sapiens	70-76
19944674-8	2010	To our knowledge this is the first report showing the upregulation of maspin expression by curcumin in breast cancer cells and taken together with the clinical data suggests a potential therapeutic role for curcumin in inducing maspin mediated inhibition of invasion of breast carcinoma cells.	Curcumin	207-215	serpin family B member 5	Homo sapiens	228-234
20145189-7	2010	In the immortalized, leukoplakia, and cancer cells, curcumin inhibited cap-dependent translation by suppressing the phosphorylation of 4E-BP1, eIF4G, eIF4B, and Mnk1, and also reduced the total levels of eIF4E and Mnk1.	Curcumin	52-60	eukaryotic translation initiation factor 4B	Homo sapiens	150-155
21086748-0	2010	Effect of curcumin and ferulic acid on modulation of expression pattern of p53 and bcl-2 proteins in 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.	Curcumin	10-18	cellular tumor antigen p53	Mesocricetus auratus	75-78
31845532-0	2020	Curcumin has immunomodulatory effects on RANKL-stimulated osteoclastogenesis in vitro and titanium nanoparticle-induced bone loss in vivo.	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	41-46
21086748-1	2010	The modulating effect of curcumin and ferulic acid was investigated on expression pattern of apoptosis regulatory p53 and bcl-2 proteins in oral squamous cell carcinoma (OSCC).	Curcumin	25-33	cellular tumor antigen p53	Mesocricetus auratus	114-117
21086748-6	2010	Oral administration of curcumin (80 mg/kg body wt) and ferulic acid (40 mg/kg body wt) to DMBA painted hamsters on days alternate to DMBA painting for 14 weeks completely inhibited tumor formation and down-regulated the expression pattern of p53 and bcl-2 proteins.	Curcumin	23-31	cellular tumor antigen p53	Mesocricetus auratus	242-245
31845532-3	2020	However, the effect on immunomodulation and the definitive mechanism by which curcumin reduces the receptor activators of nuclear factor-kappa B ligand (RANKL)-stimulated osteoclast formation and prevents the activation of osteoclastic signalling pathways are unclear.	Curcumin	78-86	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	99-151
19914224-6	2010	Moreover vitamin E or curcumin treatment ameliorated GPx1 and GR mRNA levels.	Curcumin	22-30	glutathione-disulfide reductase	Rattus norvegicus	62-64
31845532-3	2020	However, the effect on immunomodulation and the definitive mechanism by which curcumin reduces the receptor activators of nuclear factor-kappa B ligand (RANKL)-stimulated osteoclast formation and prevents the activation of osteoclastic signalling pathways are unclear.	Curcumin	78-86	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	153-158
20593964-7	2010	Curcumin also exhibited protective action against the As III induced depletion of antioxidants like catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST) and glutathione (GSH) in mice liver tissue.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Mus musculus	202-227
20026275-7	2010	Furthermore, STZ (ICV) resulted into enhanced AChE activity in hippocampus and cerebral cortex which was normalized by curcumin pre- and post-treatment.	Curcumin	119-127	acetylcholinesterase	Rattus norvegicus	46-50
20593964-7	2010	Curcumin also exhibited protective action against the As III induced depletion of antioxidants like catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST) and glutathione (GSH) in mice liver tissue.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Mus musculus	229-232
19935077-0	2010	Curcumin reduces angiotensin II-mediated cardiomyocyte growth via LOX-1 inhibition.	Curcumin	0-8	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	66-71
31845532-4	2020	In this work, the immunomodulation effect and anti-osteoclastogenesis capacities exerted by curcumin on titanium nanoparticle-stimulated macrophage polarization and on RANKL-mediated osteoclast activation and differentiation in osteoclastic precursor cells in vitro were investigated.	Curcumin	92-100	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	168-173
19935077-3	2010	We postulated that curcumin may reduce Ang II-mediated cardiomyocyte growth via AT1R and LOX-1 inhibition.	Curcumin	19-27	angiotensin II, type I receptor-associated protein	Mus musculus	80-84
19935077-3	2010	We postulated that curcumin may reduce Ang II-mediated cardiomyocyte growth via AT1R and LOX-1 inhibition.	Curcumin	19-27	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	89-94
31845532-5	2020	As expected, curcumin inhibited RANKL-stimulated osteoclast maturation and formation and had an immunomodulatory effect on macrophage polarization in vitro.	Curcumin	13-21	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	32-37
19935077-8	2010	Attenuation of redox state by curcumin resulted in abrogation of Ang II-mediated cardiomyocyte growth and atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes.	Curcumin	30-38	natriuretic peptide type B	Mus musculus	143-168
31629984-8	2019	curcumin may regulate the activation of autophagy in EAE mice by affecting the AKT/mTOR autophagy signalling pathway, further balancing central nervous system and peripheral autophagy.	Curcumin	0-8	mechanistic target of rapamycin kinase	Mus musculus	83-87
19935077-8	2010	Attenuation of redox state by curcumin resulted in abrogation of Ang II-mediated cardiomyocyte growth and atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes.	Curcumin	30-38	natriuretic peptide type B	Mus musculus	170-173
19935077-9	2010	Curcumin also reduced Ang II-mediated upregulation of AT1R and LOX-1.	Curcumin	0-8	angiotensin II, type I receptor-associated protein	Mus musculus	54-58
19935077-9	2010	Curcumin also reduced Ang II-mediated upregulation of AT1R and LOX-1.	Curcumin	0-8	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	63-68
19935077-10	2010	The forced upregulation of LOX-1 enhanced the expression of genes for AT1R, ANP, and BNP, and curcumin pretreatment reduced LOX-1 and AT1R expression and LOX-1-mediated increase in hypertrophy markers.	Curcumin	94-102	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	27-32
19935077-10	2010	The forced upregulation of LOX-1 enhanced the expression of genes for AT1R, ANP, and BNP, and curcumin pretreatment reduced LOX-1 and AT1R expression and LOX-1-mediated increase in hypertrophy markers.	Curcumin	94-102	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	124-129
19935077-10	2010	The forced upregulation of LOX-1 enhanced the expression of genes for AT1R, ANP, and BNP, and curcumin pretreatment reduced LOX-1 and AT1R expression and LOX-1-mediated increase in hypertrophy markers.	Curcumin	94-102	angiotensin II, type I receptor-associated protein	Mus musculus	134-138
19935077-10	2010	The forced upregulation of LOX-1 enhanced the expression of genes for AT1R, ANP, and BNP, and curcumin pretreatment reduced LOX-1 and AT1R expression and LOX-1-mediated increase in hypertrophy markers.	Curcumin	94-102	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	124-129
19935077-11	2010	CONCLUSIONS: Curcumin attenuates Ang II-mediated cardiomyocyte growth by inhibiting LOX-1 and AT1R expression and suppressing the heightened intracellular redox state.	Curcumin	13-21	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	84-89
19935077-11	2010	CONCLUSIONS: Curcumin attenuates Ang II-mediated cardiomyocyte growth by inhibiting LOX-1 and AT1R expression and suppressing the heightened intracellular redox state.	Curcumin	13-21	angiotensin II, type I receptor-associated protein	Mus musculus	94-98
21364631-5	2010	The pivotal role of the JNK/c-Jun/AP-1 pathway for gal-1-induced apoptosis was documented by reduction of DNA fragmentation after inhibition JNK by SP600125 (20 muM) or inhibition of AP-1 activation by curcumin (2 muM).	Curcumin	202-210	galectin 1	Homo sapiens	51-56
19941471-13	2010	Among polyphenols, curcumin and some flavonoids such as myricetin and quercetin, have been identified as potential anticancer agents with a mechanism of action that may be mediated by the Trx system.	Curcumin	19-27	thioredoxin	Homo sapiens	188-191
19766691-0	2010	Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity.	Curcumin	0-8	C-C motif chemokine ligand 2	Homo sapiens	58-63
19766691-3	2010	We found that curcumin, a natural biologically active compound extracted from rhizomes of Curcuma species, significantly inhibited the PMA-induced increase in MCP-1 expression and secretion.	Curcumin	14-22	C-C motif chemokine ligand 2	Homo sapiens	159-164
31831807-0	2019	Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives.	Curcumin	39-47	microtubule associated protein tau	Homo sapiens	6-9
19766691-4	2010	These effects of curcumin are dose dependent and correlate with the suppression of MCP-1 mRNA expression levels.	Curcumin	17-25	C-C motif chemokine ligand 2	Homo sapiens	83-88
19766691-6	2010	Therefore, one possible anti-inflammatory mechanism of curcumin may be to inhibit the secretions of inflammatory MCP-1 chemokine.	Curcumin	55-63	C-C motif chemokine ligand 2	Homo sapiens	113-118
19800021-6	2010	The IL-1-mediated induction of C/EBPdelta expression was attenuated in the presence of pharmacological inhibitors against c-Jun N-terminal kinase (JNK) (curcumin and SP600125), casein kinase 2 (CK2) (apigenin) and nuclear factor-kappaB (NF-kappaB) (NF-kappaB activation inhibitor).	Curcumin	153-161	interleukin 1 alpha	Homo sapiens	4-8
19800021-8	2010	IL-1 induced NF-kappaB DNA binding and activation by this transcription factor and this was attenuated by curcumin and apigenin.	Curcumin	106-114	interleukin 1 alpha	Homo sapiens	0-4
19782127-4	2010	Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta.	Curcumin	81-89	mitogen-activated protein kinase 8	Rattus norvegicus	158-161
19682434-9	2010	Curcumin abolished the constitutive activation of NF-kappaB in the tumor tissue; induced apoptosis, and decreased cyclin D1, VEGF, COX-2, c-myc and Bcl-2 expression in the bladder cancer tissue.	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	138-143
19676105-3	2010	In this study we show that curcumin exhibited time- and dose-dependent cytotoxicity against monolayer cultures of ovarian carcinoma cell lines with differing p53 status (wild-type p53: HEY, OVCA429; mutant p53: OCC1; null p53: SKOV3).	Curcumin	27-35	chromosome 12 open reading frame 75	Homo sapiens	211-215
19901911-10	2010	The increase in serum ALT caused by the MCD diet was significantly reduced by curcumin after 4 weeks.	Curcumin	78-86	glutamic pyruvic transaminase, soluble	Mus musculus	22-25
31831807-4	2019	In this study, we screened and tested a small library of newly synthesized curcumin derivatives against preformed recombinant tau oligomers.	Curcumin	75-83	microtubule associated protein tau	Homo sapiens	126-129
20160430-9	2010	The inhibitory action of curcumin on VEGF-A and IL-6 production was also found in primary rat pituitary cell cultures, in which FS cells are the only source of these proteins.	Curcumin	25-33	vascular endothelial growth factor A	Rattus norvegicus	37-43
20358476-6	2010	Caspase-3, caspase-8, and caspase-9 were activated, and cytochrome c and apoptosis-inducing factor (AIF) were released from mitochondria following curcumin treatment.	Curcumin	147-155	caspase 9	Homo sapiens	26-35
31831807-5	2019	Our results show that the curcumin derivatives affect and modulate the tau oligomer aggregation pathways, converting to a more aggregated non-toxic state as assessed in the human neuroblastoma SH-SY5Y cell line and primary cortical neuron cultures.	Curcumin	26-34	microtubule associated protein tau	Homo sapiens	71-74
31421247-13	2019	The phosphorylated-extracellular signal-regulated kinase, phosphorylated-JNK, and phospho-p38 levels were significantly lower in the SCI-hypoglycemia-curcumin group than in the SCI-hypoglycemia group.	Curcumin	150-158	mitogen-activated protein kinase 8	Rattus norvegicus	73-76
31754130-6	2019	The results showed that curcumin combined with 5 muM DAC may inhibit cancer cell colony formation, migration through EMT (epithelial-mesenchymal transition) process regulation, total DNMT activity, especially in DNMT3a protein expression, and may also regulate tumor suppressor gene SFRP5 expression involved in the Wnt/beta-catenin signaling pathway.	Curcumin	24-32	catenin beta 1	Homo sapiens	320-332
19616038-13	2009	Chronic administration of curcumin significantly improved memory retention in both tasks, attenuated oxidative damage, acetylcholinesterase activity and aluminium concentration in aluminium treated rats (P&lt;0.05).	Curcumin	26-34	acetylcholinesterase	Rattus norvegicus	119-139
20158382-0	2010	Curcumin inhibits GPVI-mediated platelet activation by interfering with the kinase activity of Syk and the subsequent activation of PLCgamma2.	Curcumin	0-8	glycoprotein VI platelet	Homo sapiens	18-22
19808779-4	2009	We recently showed that curcumin suppressed gene expression of LDL receptor in activated HSCs in vitro by repressing gene expression of the transcription factor sterol regulatory element binding protein-2 (SREBP-2), leading to the reduction in the level of intracellular cholesterol in HSCs and to the attenuation of the stimulatory effects of LDL on HSCs activation.	Curcumin	24-32	low density lipoprotein receptor	Homo sapiens	63-75
20158382-4	2010	Curcumin inhibited human platelet aggregation and dense granule secretion induced by GPVI agonist convulxin in a concentration-dependent manner.	Curcumin	0-8	glycoprotein VI platelet	Homo sapiens	85-89
31827678-10	2019	Lastly, we discuss the possibility of using small molecule antioxidants, such as N-acetyl cysteine, resveratrol, and curcumin, to augment HSC function and improve the therapeutic efficacy of BM transplantation.	Curcumin	117-125	fucosyltransferase 1 (H blood group)	Homo sapiens	138-141
20158382-9	2010	We conclude that curcumin inhibits platelet activation induced by GPVI agonists through interfering with the kinase activity of Syk and the subsequent activation of PLCgamma2.	Curcumin	17-25	glycoprotein VI platelet	Homo sapiens	66-70
19765405-6	2009	In Western blotting analysis, the membrane protein level of glucose transporter 4 (GLUT4) increased by curcumin was also reversed by blockade of M(1)-mAChR or PLC-PI3K pathway in a same manner.	Curcumin	103-111	solute carrier family 2 member 4	Rattus norvegicus	60-81
19715674-2	2009	Recent reports have shown curcumin to have antioxidant, anti-inflammatory and anti-tumor properties as well as affecting the 5"-AMP activated protein kinase (AMPK), mTOR and STAT-3 signaling pathways.	Curcumin	26-34	signal transducer and activator of transcription 3	Rattus norvegicus	174-180
19793800-8	2009	In vitro studies of murine K-ras-induced lung adenocarcinoma cell lines (LKR-10 and LKR-13) indicated direct anti-tumoral effects of curcumin by reducing cell viability, colony formation and inducing apoptosis.	Curcumin	133-141	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	27-32
19793800-9	2009	We conclude that curcumin suppresses the progression of K-ras-induced lung cancer in mice by inhibiting intrinsic and extrinsic inflammation and by direct anti-tumoral effects.	Curcumin	17-25	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	56-61
19765405-6	2009	In Western blotting analysis, the membrane protein level of glucose transporter 4 (GLUT4) increased by curcumin was also reversed by blockade of M(1)-mAChR or PLC-PI3K pathway in a same manner.	Curcumin	103-111	solute carrier family 2 member 4	Rattus norvegicus	83-88
31703057-9	2019	Interestingly, the inhibitory effect of TRIM48 overexpression on human GBM cell growth and the inactivation of ERK1/2 were significantly alleviated with additional curcumin treatment, while it the promoted the effect of siTRIM48 on human GBM cell growth, and the activation of ERK1/2 was significantly alleviated with additional PD98059 treatment.	Curcumin	164-172	tripartite motif containing 48	Homo sapiens	40-46
19917353-11	2009	Curcumin treatment in group III produced a significant increase in GSH levels, as well as a decrease in intestinal mucosal injury scores, MPO activity, MDA, and NO levels when compared with group II (P &lt; .05).	Curcumin	0-8	myeloperoxidase	Rattus norvegicus	138-141
31827700-0	2019	Dietary Supplementation of the Antioxidant Curcumin Halts Systemic LPS-Induced Neuroinflammation-Associated Neurodegeneration and Memory/Synaptic Impairment via the JNK/NF-kappaB/Akt Signaling Pathway in Adult Rats.	Curcumin	43-51	mitogen-activated protein kinase 8	Rattus norvegicus	165-168
19699734-4	2009	A dietary supplement of curcumin reversed the increase in levels of activity and mRNA of tartrate-resistant acid phosphatase (TRAP) and cathepsin K to control values.	Curcumin	24-32	cathepsin K	Rattus norvegicus	136-147
31827700-2	2019	In the present study, we explored the neuroprotective effect of curcumin against lipopolysaccharide- (LPS-) induced reactive oxygen species- (ROS-) mediated neuroinflammation, neurodegeneration, and memory deficits in the adult rat hippocampus via regulation of the JNK/NF-kappaB/Akt signaling pathway.	Curcumin	64-72	mitogen-activated protein kinase 8	Rattus norvegicus	266-269
19288529-0	2009	Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells.	Curcumin	14-22	epidermal growth factor	Homo sapiens	32-55
19288529-0	2009	Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells.	Curcumin	14-22	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	64-70
31432177-0	2019	Curcumin inhibits cell proliferation and migration in NSCLC through a synergistic effect on the TLR4/MyD88 and EGFR pathways.	Curcumin	0-8	toll like receptor 4	Homo sapiens	96-100
19288529-1	2009	This study investigated whether genistein and curcumin affect epidermal growth factor (EGF)-induced MUC5AC mucin production and gene expression from human airway epithelial cells.	Curcumin	46-54	epidermal growth factor	Homo sapiens	62-85
19288529-1	2009	This study investigated whether genistein and curcumin affect epidermal growth factor (EGF)-induced MUC5AC mucin production and gene expression from human airway epithelial cells.	Curcumin	46-54	epidermal growth factor	Homo sapiens	87-90
19288529-3	2009	The results were as follows: (1) genistein and curcumin inhibited the production of MUC5AC mucin protein induced by EGF, dose-dependently; (2) genistein and curcumin also inhibited the expression of MUC5AC mucin gene induced by EGF.	Curcumin	47-55	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	84-90
19156536-6	2009	Treatment with curcumin significantly increased TCF7L2 gene expression to 3.24 fold (1.7-log fold) (P = 0.003) compared to the controls while treatment with LPS decreased TCF7L2 gene expression to 0.88-fold (-0.18-log).	Curcumin	15-23	transcription factor 7 like 2	Homo sapiens	48-54
19156536-9	2009	The contrary effect of curcumin and LPS on expression of TCF7L2 in pancreatic cells supports a role for TCF7L2 in their survival and function in inflammatory conditions.	Curcumin	23-31	transcription factor 7 like 2	Homo sapiens	57-63
31432177-7	2019	Furthermore, curcumin significantly inhibited the expression of Toll-like receptor 4 (TLR4)/MyD88 and EGFR in a dose- and time-dependent manner.	Curcumin	13-21	toll like receptor 4	Homo sapiens	64-84
19156536-9	2009	The contrary effect of curcumin and LPS on expression of TCF7L2 in pancreatic cells supports a role for TCF7L2 in their survival and function in inflammatory conditions.	Curcumin	23-31	transcription factor 7 like 2	Homo sapiens	104-110
19288529-3	2009	The results were as follows: (1) genistein and curcumin inhibited the production of MUC5AC mucin protein induced by EGF, dose-dependently; (2) genistein and curcumin also inhibited the expression of MUC5AC mucin gene induced by EGF.	Curcumin	47-55	epidermal growth factor	Homo sapiens	116-119
19288529-3	2009	The results were as follows: (1) genistein and curcumin inhibited the production of MUC5AC mucin protein induced by EGF, dose-dependently; (2) genistein and curcumin also inhibited the expression of MUC5AC mucin gene induced by EGF.	Curcumin	47-55	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	199-205
20578454-1	2009	The present study investigated the effect of curcumin, a phenolic compound with yellow color from Curcuma longa L., on the expression of the apoptosis-related genes [BAX (Bcl-2 associated protein X), PKB, p53, MDM2 (mouse double minute 2), caspase 9, c-Ski, smad1 and smad4] in hamster opisthorchiasis.	Curcumin	45-53	SMAD family member 1	Mus musculus	258-263
31432177-7	2019	Furthermore, curcumin significantly inhibited the expression of Toll-like receptor 4 (TLR4)/MyD88 and EGFR in a dose- and time-dependent manner.	Curcumin	13-21	toll like receptor 4	Homo sapiens	86-90
20578454-1	2009	The present study investigated the effect of curcumin, a phenolic compound with yellow color from Curcuma longa L., on the expression of the apoptosis-related genes [BAX (Bcl-2 associated protein X), PKB, p53, MDM2 (mouse double minute 2), caspase 9, c-Ski, smad1 and smad4] in hamster opisthorchiasis.	Curcumin	45-53	SMAD family member 4	Mus musculus	268-273
19524420-0	2009	Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcription.	Curcumin	0-8	matrix metallopeptidase 1	Homo sapiens	135-140
20079164-6	2009	RESULTS: IL-1 lowered the mRNA level and protein expression of Sox9 and collagen type II in the cultured intervertebral disc cells in a dose dependent manner (P &lt; 0.05), and this effect was attenuated by curcumin.	Curcumin	207-215	interleukin 1 alpha	Homo sapiens	9-13
19524420-5	2009	The effect of curcumin"s on the activity of matrix metalloproteinase-1, 3, 9 were analyzed by RT-PCR.	Curcumin	14-22	matrix metallopeptidase 1	Homo sapiens	44-70
31432177-8	2019	Conversely, EGF reversed the inhibitory action of curcumin on TLR4/MyD88.	Curcumin	50-58	toll like receptor 4	Homo sapiens	62-66
20079164-8	2009	IL-1 at concentrations of 0.1 ng/ml, 1 ng/ml and 10 ng/ml could stimulate the activity of NF-kappaB in the intervertebral disc cells in a dose dependent manner (P &lt; 0.05) that was inhibited by curcumin.	Curcumin	196-204	interleukin 1 alpha	Homo sapiens	0-4
32239852-12	2019	Curcumin can up-regulate expression of Nrf2 and HO-1, alleviate oxidative stress induced by overtraining, enhance Bcl-2 expression and attenuate Bax expression, thereby inhibiting excessive spleen apoptosis of rats, protecting the structure and function of spleen.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	145-148
19573523-0	2009	Potent growth suppressive activity of curcumin in human breast cancer cells: Modulation of Wnt/beta-catenin signaling.	Curcumin	38-46	catenin beta 1	Homo sapiens	95-107
19573523-5	2009	The effect of curcumin (20microM) treatment on expression of Wnt/beta-catenin pathway components in breast cancer cells (MCF-7 and MDA-MB-231) was analyzed by immunofluorescence and Western blotting.	Curcumin	14-22	catenin beta 1	Homo sapiens	65-77
19573523-6	2009	Curcumin was found to effectively inhibit the expression of several Wnt/beta-catenin pathway components-disheveled, beta-catenin, cyclin D1 and slug in both MCF-7 and MDA-MB-231.	Curcumin	0-8	catenin beta 1	Homo sapiens	72-84
19573523-6	2009	Curcumin was found to effectively inhibit the expression of several Wnt/beta-catenin pathway components-disheveled, beta-catenin, cyclin D1 and slug in both MCF-7 and MDA-MB-231.	Curcumin	0-8	catenin beta 1	Homo sapiens	116-128
31666589-6	2019	After screening, curcumin, syringic acid, and resveratrol were found in high affinity with DPP IV enzymes.	Curcumin	17-25	dipeptidylpeptidase 4	Mus musculus	91-97
19573523-7	2009	Immunofluorescence analysis showed that curcumin markedly reduced the nuclear expression of disheveled and beta-catenin proteins.	Curcumin	40-48	catenin beta 1	Homo sapiens	107-119
19573523-8	2009	Further, the protein levels of the positively regulated beta-catenin targets-cyclin D1 and slug, were downregulated by curcumin treatment.	Curcumin	119-127	catenin beta 1	Homo sapiens	56-68
31666589-7	2019	In enzymatic tests, curcumin and resveratrol showed potential inhibition of DPP IV.	Curcumin	20-28	dipeptidylpeptidase 4	Mus musculus	76-82
19573523-10	2009	In conclusion, our data demonstrated that the efficacy of curcumin in inhibition of cell proliferation and induction of apoptosis might occur through modulation of beta-catenin pathway in human breast cancer cells.	Curcumin	58-66	catenin beta 1	Homo sapiens	164-176
31666589-8	2019	In vitro assays, curcumin inhibited of DPP IV activity in Caco-2 cells and ERK phosphorylation in C2C12 cells.	Curcumin	17-25	dipeptidyl peptidase 4	Homo sapiens	39-45
31666589-10	2019	Curcumin targeted to DPP IV for reducing blood glucose, it possesses potential and alternative substitution of synthetic clinical drugs for the medication of diabetes.	Curcumin	0-8	dipeptidylpeptidase 4	Mus musculus	21-27
31656916-7	2019	Furthermore, resveratrol and curcumin decreased the content of m6A and decreased the enrichment of m6A on the transcripts of tight junction proteins and on heme oxygenase-1 in the intestine.	Curcumin	29-37	heme oxygenase 1	Homo sapiens	156-172
19539747-0	2009	Curcumin ameliorates rabbits"s steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha.	Curcumin	0-8	tumor necrosis factor	Oryctolagus cuniculus	92-101
19539747-7	2009	Curcumin administration together with the high-fat diet led to rabbits with a lower NASH grade and lower levels of aminotransferases, higher values for mitochondrial antioxidants, lower mitochondrial reactive oxygen species, an improved mitochondrial function, and lower levels of TNF-alpha protein levels.	Curcumin	0-8	tumor necrosis factor	Oryctolagus cuniculus	281-290
19655336-8	2009	Curcumin decreased COX-2 expression and inhibited phosphorylation of EGFR in SCC-1 cells.	Curcumin	0-8	epidermal growth factor receptor	Mus musculus	69-73
19702951-10	2009	The siRNA for beta-catenin suppressed the IL-1alpha-induced OPG production in both PDL cells and hGFs, whereas the AP-1 inhibitor curcumin augmented the IL-1alpha-induced OPG production in PDL cells, but not in hGFs.	Curcumin	130-138	interleukin 1 alpha	Homo sapiens	153-162
31595849-5	2019	Finally, the effect of Curcumin on the transcriptional efficiencies of miR-146a, nNOS, eNOS and iNOS was studied using luciferase assay.	Curcumin	23-31	microRNA 146a	Homo sapiens	71-79
19763044-1	2009	We investigated whether oral administration of curcumin suppressed type II collagen-induced arthritis (CIA) in mice and its effect and mechanism on matrix metalloproteinase (MMP)-1 and MMP-3 production in CIA mice, RA fibroblast-like synoviocytes (FLS), and chondrocytes.	Curcumin	47-55	matrix metallopeptidase 3	Mus musculus	185-190
19763044-6	2009	Production of MMP-1 and MMP-3 were inhibited by curcumin in CIA hind paw sections and tumor necrosis factor (TNF)-alpha-stimulated FLS and chondrocytes in a dose-dependent manner.	Curcumin	48-56	matrix metallopeptidase 3	Mus musculus	24-29
31595849-10	2019	Moreover, Curcumin enhanced miR-146a expression, while reducing the expression of nNOS, iNOS, cGPM, caspase-3 and PKG as well as the synthesis of NO.	Curcumin	10-18	microRNA 146a	Homo sapiens	28-36
19763044-9	2009	This study suggests that the suppression of MMP-1 and MMP-3 production by curcumin in CIA is mediated through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway.	Curcumin	74-82	matrix metallopeptidase 3	Mus musculus	54-59
31595849-10	2019	Moreover, Curcumin enhanced miR-146a expression, while reducing the expression of nNOS, iNOS, cGPM, caspase-3 and PKG as well as the synthesis of NO.	Curcumin	10-18	protein kinase cGMP-dependent 1	Homo sapiens	114-117
31595849-11	2019	Curcumin may exert its effect by reducing the transcriptional efficiency of iNOS promoter, while increasing the transcriptional efficiency of miR-146a promoter.	Curcumin	0-8	microRNA 146a	Homo sapiens	142-150
31595849-13	2019	The protective effect of Curcumin against RIRI may be mediated by its regulation of cell apoptosis through the miR-146a/nNOS/NO/cGMP/PKG signaling pathway.	Curcumin	25-33	microRNA 146a	Homo sapiens	111-119
31595849-13	2019	The protective effect of Curcumin against RIRI may be mediated by its regulation of cell apoptosis through the miR-146a/nNOS/NO/cGMP/PKG signaling pathway.	Curcumin	25-33	protein kinase cGMP-dependent 1	Homo sapiens	133-136
31734652-16	2019	Leptin was more potent than curcumin due to the stimulatory effect of leptin on glucocorticoid release to counteract inflammation.	Curcumin	28-36	leptin	Homo sapiens	70-76
31593984-2	2019	Methods: The effect of curcumin on interleukin (IL)-1beta induced-proinflammatory cytokine production was determined using quantitative real-time PCR, enzyme-linked immunosorbent assay (ELISA), and Western blot analysis.	Curcumin	23-31	interleukin 1 alpha	Homo sapiens	35-57
31593984-5	2019	Results: Treatment with curcumin resulted in a dose- and time-dependent decrease in IL-1beta-induced synthesis of inflammatory cytokines, including IL-6, IL-8, MCP-1, and ICAM-1 at both mRNA and protein levels.	Curcumin	24-32	interleukin 1 alpha	Homo sapiens	84-92
31593984-5	2019	Results: Treatment with curcumin resulted in a dose- and time-dependent decrease in IL-1beta-induced synthesis of inflammatory cytokines, including IL-6, IL-8, MCP-1, and ICAM-1 at both mRNA and protein levels.	Curcumin	24-32	C-C motif chemokine ligand 2	Homo sapiens	160-165
31593984-8	2019	Curcumin significantly suppressed IL-1beta-induced phosphorylated extracellular signal-regulated kinase, Akt, c-Jun NH(2)-terminal kinase, and nuclear factor kappa-light-chain-enhancer of activated B cells, p65 proteins and stimulated beta-catenin translocation into nucleus during adipogenesis.	Curcumin	0-8	interleukin 1 alpha	Homo sapiens	34-42
31593984-8	2019	Curcumin significantly suppressed IL-1beta-induced phosphorylated extracellular signal-regulated kinase, Akt, c-Jun NH(2)-terminal kinase, and nuclear factor kappa-light-chain-enhancer of activated B cells, p65 proteins and stimulated beta-catenin translocation into nucleus during adipogenesis.	Curcumin	0-8	catenin beta 1	Homo sapiens	235-247
31593984-9	2019	Conclusions: Curcumin inhibits proinflammatory cytokine production, ROS synthesis, and adipogenesis in orbital fibroblasts of GO patients in vitro possibly related to multiple proinflammatory signaling molecules and beta-catenin pathway.	Curcumin	13-21	catenin beta 1	Homo sapiens	216-228
31539917-5	2019	Under the same experimental conditions, the reference MAO inhibitor, curcumin, displays IC50 values of 5.01 microM and 2.55 microM for the inhibition of MAO-A and MAO-B, respectively.	Curcumin	69-77	monoamine oxidase A	Homo sapiens	153-158
31539917-7	2019	Curcumin in turn, displays a Ki value of 3.08 microM for the inhibition of MAO-A.	Curcumin	0-8	monoamine oxidase A	Homo sapiens	75-80
31579620-5	2019	Further study showed that curcumin improved the gap junction intercellular communication (GJIC) function, and upregulated the proteins essential to gap junction, such as connexin 32 and connexin 43, indicating the potential role in enhancing the bystander effect of HSV-TK/GCV.	Curcumin	26-34	gap junction protein, beta 1	Mus musculus	170-181
31579620-5	2019	Further study showed that curcumin improved the gap junction intercellular communication (GJIC) function, and upregulated the proteins essential to gap junction, such as connexin 32 and connexin 43, indicating the potential role in enhancing the bystander effect of HSV-TK/GCV.	Curcumin	26-34	gap junction protein, beta 1	Mus musculus	186-197
31136038-4	2019	Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer.	Curcumin	0-8	heat shock protein family B (small) member 1	Homo sapiens	72-77
31136038-4	2019	Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer.	Curcumin	0-8	heat shock protein 90 alpha family class A member 1	Homo sapiens	104-109
31074052-4	2019	In the present study, we examined the effect of curcumin on the gene expression of caspase-8, caspase-10, and anti-apoptotic protein c-FLIP, in HAM/TSP patients.	Curcumin	48-56	caspase 10	Homo sapiens	94-104
31511210-0	2019	[Curcumin suppresses invasiveness and migration of human glioma cells in vitro by inhibiting HDGF/beta-catenin complex].	Curcumin	1-9	catenin beta 1	Homo sapiens	98-110
31511210-6	2019	In the two glioma cell lines, curcumin significantly suppressed the invasion and migration of the cells (P &amp;lt; 0.05) and lowered the expressions of hepatoma-derived growth factor (HDGF), Ncadherin, vimentin, Snail and Slug, but increased the expression of E-cadherin.	Curcumin	30-38	vimentin	Homo sapiens	203-211
31511210-7	2019	Interference of HDGF in curcumin-treated glioma cells synergistically inhibited the epithelial-mesenchymal transition (EMT) signals, while overexpression of HDGF significantly reversed the inhibitory effect of curcumin on EMT; curcumin treatment could significantly reduce the binding of HDGF to beta-catenin.	Curcumin	24-32	catenin beta 1	Homo sapiens	296-308
31511210-8	2019	CONCLUSIONS: Curcumin suppresses EMT signal by reducing HDGF/beta-catenin complex and thereby lowers the migration and invasion abilities of human glioma cells in vitro.	Curcumin	13-21	catenin beta 1	Homo sapiens	61-73
31455356-8	2019	Curcumin administration protected THP-1 and RAW264.7 cells from MSU induced mitochondrial damage through preventing mitochondrial membrane potential reduction, decreasing mitochondria ROS, and then inhibited the activity of NLRP3 inflammasome.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	224-229
31455356-11	2019	CONCLUSION: Curcumin administration effectively alleviated MSU-induced inflammation by suppressing the degradation of IkappaBalpha, the activation NF-kappaB signaling pathway, the damage of mitochondria, and the activity of NLRP3 inflammasome.	Curcumin	12-20	NLR family, pyrin domain containing 3	Mus musculus	224-229
31511778-0	2019	Curcumin Inhibits Joint Contracture through PTEN Demethylation and Targeting PI3K/Akt/mTOR Pathway in Myofibroblasts from Human Joint Capsule.	Curcumin	0-8	phosphatase and tensin homolog	Homo sapiens	44-48
31511778-8	2019	Methylation-specific PCR results suggested that curcumin was able to demethylate PTEN in a similar manner to the demethylation agent 5-azacytidine, increasing PTEN expression and further inhibiting phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling.	Curcumin	48-56	phosphatase and tensin homolog	Homo sapiens	81-85
19524420-10	2009	MMP1 mRNA expression in BT-483 and MDA-MB-231 had significantly decreased in curcumin treatment group compared with control group.	Curcumin	77-85	matrix metallopeptidase 1	Homo sapiens	0-4
31511778-8	2019	Methylation-specific PCR results suggested that curcumin was able to demethylate PTEN in a similar manner to the demethylation agent 5-azacytidine, increasing PTEN expression and further inhibiting phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling.	Curcumin	48-56	phosphatase and tensin homolog	Homo sapiens	159-163
31033006-4	2019	Moreover, the expression of glutathione peroxidase (GPX)-1 gene and the activity of anti-oxidant enzymes were significantly higher (p < 0.001) in curcumin-treated mice.	Curcumin	146-154	glutathione peroxidase 1	Mus musculus	28-58
19607909-6	2009	Curcumin increased the levels of HSP27 in PBMC only in presence of low doses and not at high doses of malathion.	Curcumin	0-8	heat shock protein family B (small) member 1	Homo sapiens	33-38
19607909-7	2009	Both NAC and curcumin were able to prevent malathion-mediated apoptosis of PBMC effectively at non-cholinergic doses and at this concentration of malathion, HSP27 induction keeps apoptosis and GSH depletion under control.	Curcumin	13-21	heat shock protein family B (small) member 1	Homo sapiens	157-162
19763044-0	2009	Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway.	Curcumin	23-31	matrix metallopeptidase 3	Mus musculus	94-99
31029341-0	2019	Folate-PEG/Hyd-curcumin/C18-g-PSI micelles for site specific delivery of curcumin to colon cancer cells via Wnt/beta-catenin signaling pathway.	Curcumin	15-23	catenin beta 1	Homo sapiens	112-124
19723881-6	2009	Pretreatment of peripheral blood mononuclear cells from healthy donors with curcumin also inhibited the ability of IFN-alpha, IFN-gamma, and interleukin-2 to phosphorylate STAT proteins critical for their antitumor activity (STAT1 and STAT5, respectively) and their respective downstream gene expression as measured by real time PCR.	Curcumin	76-84	signal transducer and activator of transcription 5A	Homo sapiens	235-240
19723881-7	2009	Finally, stimulation of natural killer (NK) cells with curcumin reduced the level of interleukin-12-induced IFN-gamma secretion, and production of granzyme b or IFN-gamma upon coculture with A375 melanoma cells or NK-sensitive K562 cells as targets.	Curcumin	55-63	granzyme B	Homo sapiens	147-157
19661333-5	2009	Curcumin decreased total expression of mTOR, Raptor and Rictor protein and mRNA levels.	Curcumin	0-8	RPTOR independent companion of MTOR complex 2	Homo sapiens	56-62
19661333-6	2009	Surprisingly, curcumin induced phosphorylation of Akt(Ser 473); this effect may be attributed to a decrease in levels of the PHLPP1 phosphatase, an inhibitor of Akt.	Curcumin	14-22	PH domain and leucine rich repeat protein phosphatase 1	Homo sapiens	125-131
31029341-0	2019	Folate-PEG/Hyd-curcumin/C18-g-PSI micelles for site specific delivery of curcumin to colon cancer cells via Wnt/beta-catenin signaling pathway.	Curcumin	73-81	catenin beta 1	Homo sapiens	112-124
19605645-8	2009	Treatment of the 3xTg-AD mice on high-fat diet with fish oil or curcumin or a combination of both for 4 months reduced phosphorylated JNK, IRS-1, and tau and prevented the degradation of total IRS-1.	Curcumin	64-72	insulin receptor substrate 1	Mus musculus	139-144
31029341-1	2019	Curcumin shows a potential anticancer activity, as it is involved in signaling pathway suppressing beta-catenin response transcription.	Curcumin	0-8	catenin beta 1	Homo sapiens	99-111
19605645-8	2009	Treatment of the 3xTg-AD mice on high-fat diet with fish oil or curcumin or a combination of both for 4 months reduced phosphorylated JNK, IRS-1, and tau and prevented the degradation of total IRS-1.	Curcumin	64-72	insulin receptor substrate 1	Mus musculus	193-198
19605645-10	2009	Mice fed with fish oil and curcumin for 1 month had more significant effects on Y-maze, and the combination showed more significant inhibition of JNK, IRS-1, and tau phosphorylation.	Curcumin	27-35	insulin receptor substrate 1	Mus musculus	151-156
31029341-2	2019	In this study, the effects of curcumin released from the biocompatible and biodegradable polyaspartamide based micelles on colon cancer treatment via the Wnt/beta-catenin signaling pathway are investigated.	Curcumin	30-38	catenin beta 1	Homo sapiens	158-170
21475877-0	2009	Curcumin induces caspase and calpain-dependent apoptosis in HT29 human colon cancer cells.	Curcumin	0-8	caspase 9	Homo sapiens	17-24
31423287-0	2019	Curcumin enhances cisplatin sensitivity by suppressing NADPH oxidase 5 expression in human epithelial cancer.	Curcumin	0-8	NADPH oxidase 5	Homo sapiens	55-70
19764552-9	2009	The CTGF protein levels were inhibited obviously after HLF-02 cells were incubated with PDTC or curcumin.	Curcumin	96-104	HLF transcription factor, PAR bZIP family member	Homo sapiens	55-58
19494316-6	2009	Thrombin-induced CTGF expression and CTGF-luciferase activity were inhibited by a protease-activated receptor 1 antagonist (SCH79797), the dominant-negative mutants (DNs) of ASK1 and JNK1/2, and an AP-1 inhibitor (curcumin).	Curcumin	214-222	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	174-178
19401701-8	2009	Concomitant decrease in the expressions of cyclin B1 and Cdk1 were seen in curcumin-treated cells.	Curcumin	75-83	cyclin B1	Homo sapiens	43-52
19401701-8	2009	Concomitant decrease in the expressions of cyclin B1 and Cdk1 were seen in curcumin-treated cells.	Curcumin	75-83	cyclin dependent kinase 1	Homo sapiens	57-61
19401701-10	2009	Silencing ATM/Chk1 expression by transfecting BxPC-3 cells with ATM or Chk1-specific SiRNA blocked the phosphorylation of ATM, Chk1 and Cdc25C and protected the cells from curcumin-mediated G2/M arrest and apoptosis.	Curcumin	172-180	ATM serine/threonine kinase	Homo sapiens	10-13
19401701-10	2009	Silencing ATM/Chk1 expression by transfecting BxPC-3 cells with ATM or Chk1-specific SiRNA blocked the phosphorylation of ATM, Chk1 and Cdc25C and protected the cells from curcumin-mediated G2/M arrest and apoptosis.	Curcumin	172-180	cell division cycle 25C	Homo sapiens	136-142
19401701-11	2009	This study reflects the critical role of ATM/Chk1 in curcumin-mediated G2/M cell cycle arrest and apoptosis in pancreatic cancer cells.	Curcumin	53-61	ATM serine/threonine kinase	Homo sapiens	41-44
19020987-4	2009	In animals co-administered with curcumin and aluminium, the levels of lipid peroxidation, activities of PKC and AChE were significantly lowered while the activities of SOD, GPx, GST and Na(+), K(+)-ATPase were significantly enhanced in the two brain regions studied indicating curcumin"s protective effects against aluminium toxicity.	Curcumin	32-40	acetylcholinesterase	Rattus norvegicus	112-116
19020987-4	2009	In animals co-administered with curcumin and aluminium, the levels of lipid peroxidation, activities of PKC and AChE were significantly lowered while the activities of SOD, GPx, GST and Na(+), K(+)-ATPase were significantly enhanced in the two brain regions studied indicating curcumin"s protective effects against aluminium toxicity.	Curcumin	32-40	hematopoietic prostaglandin D synthase	Rattus norvegicus	178-181
19020987-5	2009	Though the magnitudes of curcumin-induced alterations varied in young and old animals, the results of the present study also demonstrated that curcumin exerts a protective effect against aluminium-induced elevation of ageing-related changes by modulating the extent of oxidative stress (by upregulating the activities of antioxidant enzymes) and by regulating the activities of Na(+), K(+) ATPase, PKC and AChE.	Curcumin	143-151	acetylcholinesterase	Rattus norvegicus	406-410
18555241-9	2009	Curcumin stimulated caspase-3 and caspase-9 expression while inhibiting extracellular signal-regulated kinase 1 (ERK 1), ERK 2, and nuclear factor kappa B (NF-kappaB), suggesting regulation of leiomyocyte apoptosis.	Curcumin	0-8	caspase 9	Homo sapiens	34-43
31423287-7	2019	Treatment with curcumin may suppress NOX5 expression in cancer cells and enhance sensitivity to cisplatin treatment.	Curcumin	15-23	NADPH oxidase 5	Homo sapiens	37-41
31366901-16	2019	Curcumin loaded- SLN can be suggested in future preclinical and clinical studies to test its concomitant use during radiotherapy treatments with the double implications of being a radiosensitizing molecule against cancer cells, with a protective role against IR side effects.	Curcumin	0-8	sarcolipin	Homo sapiens	17-20
19321585-0	2009	Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice.	Curcumin	8-16	interleukin 2	Mus musculus	68-81
19359068-0	2009	Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities.	Curcumin	39-47	tyrosinase	Mus musculus	123-133
31331376-0	2019	Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/beta-catenin pathway.	Curcumin	0-8	catenin beta 1	Homo sapiens	76-88
19299451-8	2009	Curcumin interrupts leptin signaling by reducing phosphorylation levels of leptin receptor (Ob-R) and its downstream intermediators.	Curcumin	0-8	leptin receptor	Homo sapiens	75-90
19299451-8	2009	Curcumin interrupts leptin signaling by reducing phosphorylation levels of leptin receptor (Ob-R) and its downstream intermediators.	Curcumin	0-8	leptin receptor	Homo sapiens	92-96
19299451-9	2009	In addition, curcumin suppresses gene expression of Ob-R in HSCs, which requires the activation of endogenous peroxisome proliferator-activated receptor-gamma and de novo synthesis of glutathione.	Curcumin	13-21	leptin receptor	Homo sapiens	52-56
19161989-0	2009	Curcumin-induced degradation of PKC delta is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats.	Curcumin	0-8	neural cell adhesion molecule 1	Rattus norvegicus	78-82
19288022-8	2009	Curcumin increased the protein expressions of p21 and Bax, but decreased the protein expression of p53 and Bcl-2 in MDA-MB-231 cells.	Curcumin	0-8	H3 histone pseudogene 16	Homo sapiens	46-49
19373661-5	2009	Furthermore, rapamycin and curcumin increased caspase 9, 3 and 7 activity, decreased anti-apoptotic bcl-2 levels, and increased the pro-apoptotic protein Bax.	Curcumin	27-35	caspase 9	Homo sapiens	46-55
19299451-10	2009	In conclusion, our results demonstrate that curcumin abrogates the stimulatory effect of leptin on HSC activation in vitro by reducing the phosphorylation level of Ob-R, stimulating peroxisome proliferator-activated receptor-gamma activity, and attenuating oxidative stress, leading to the suppression of Ob-R gene expression and interruption of leptin signaling.	Curcumin	44-52	leptin receptor	Homo sapiens	164-168
19299451-10	2009	In conclusion, our results demonstrate that curcumin abrogates the stimulatory effect of leptin on HSC activation in vitro by reducing the phosphorylation level of Ob-R, stimulating peroxisome proliferator-activated receptor-gamma activity, and attenuating oxidative stress, leading to the suppression of Ob-R gene expression and interruption of leptin signaling.	Curcumin	44-52	leptin receptor	Homo sapiens	305-309
19781154-7	2009	The protein expressions of MMP-2 and MMP-9 were significantly down-regulated in HF group and could be significantly up-regulated by Curcumin treatment.	Curcumin	132-140	72 kDa type IV collagenase	Oryctolagus cuniculus	27-32
31331376-3	2019	This review focuses on the interest of use curcumin in cancer therapy by acting on the WNT/beta-catenin pathway to repress chronic inflammation and oxidative stress.	Curcumin	43-51	catenin beta 1	Homo sapiens	91-103
20225028-14	2009	Curcumin stimulates translocation of misfolded protein from the endoplasmic reticulum and proved useful for selected myelin protein zero and PMP22 mutants in vitro and in the animal models Trembler and TremblerJ.	Curcumin	0-8	peripheral myelin protein 22	Homo sapiens	141-146
31331376-5	2019	Curcumin administration participates to the downregulation of the WNT/beta-catenin pathway and thus, through this action, in tumor growth control.	Curcumin	0-8	catenin beta 1	Homo sapiens	70-82
31331376-11	2019	The administration of curcumin in cancer treatment would thus appear to be an interesting therapeutic strategy, which acts through their role in regulating WNT/beta-catenin pathway and PPARgamma activity levels.	Curcumin	22-30	catenin beta 1	Homo sapiens	160-172
30585634-8	2019	In the core signaling pathways of GBM, nano micelles curcumin either significantly influences the NF-kappaB pathway by decreasing p-65 expression or significantly inhibits the Wnt/beta-catenin pathway by declining cyclin D1 expression.	Curcumin	53-61	catenin beta 1	Homo sapiens	180-192
19384583-8	2009	Curcumin also significantly reduced brain Abeta burden and microglia activation.	Curcumin	0-8	amyloid beta (A4) precursor protein	Mus musculus	42-47
19279034-0	2009	Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways.	Curcumin	21-29	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	120-142
30585634-9	2019	In conclusion, we have shown that nano micelles curcumin effectively prevent proliferation, and invasion of GBM cells through perturbation of Wnt/beta-catenin and NF-kappaB pathways, suggesting further investigations on the therapeutic application of this novel anticancer drug in in vivo models.	Curcumin	48-56	catenin beta 1	Homo sapiens	146-158
31145652-0	2019	Curcumin Promotes Proliferation of Adult Neural Stem Cells and the Birth of Neurons in Alzheimer"s Disease Mice via Notch Signaling Pathway.	Curcumin	0-8	notch 1	Mus musculus	116-121
19152370-7	2009	Curcumin (1.25 approximately 10 microM) concentration-dependently suppressed TGF-beta1-induced alpha-SMA expression and collagen deposition in HSC-T6 cells, without cytotoxicity.	Curcumin	0-8	actin gamma 2, smooth muscle	Rattus norvegicus	95-104
18830899-14	2009	Tissue expression of NF-kB was increased in colon segments from trinitrobenzenesulphonic acid -treated rats and this was inhibited in rats treated with curcumin.	Curcumin	152-160	nuclear factor kappa B subunit 1	Rattus norvegicus	21-26
31145652-4	2019	APP/PS1 transgenic mice as animal models were treated with curcumin, and a significant improvement in learning and memory function was observed.	Curcumin	59-67	presenilin 1	Mus musculus	4-7
18830899-15	2009	CONCLUSIONS: Based on these findings it is concluded that curcumin prevented the reduction in carbachol-induced contraction in trinitrobenzenesulphonic acid -treated rats by modulating NF-kB signaling pathway.	Curcumin	58-66	nuclear factor kappa B subunit 1	Rattus norvegicus	185-190
19344704-4	2009	Whereas the expression of glutathione peroxidase (GPx), catalase, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and heme oxygenase-1 (HO-1) increased with curcumin concentration and also with increase in time of incubation, the expression of Mn- superoxide dismutase (Mn-SOD) showed concentration dependant repression upon treatment with curcumin.	Curcumin	148-156	heme oxygenase 1	Homo sapiens	109-125
19344704-4	2009	Whereas the expression of glutathione peroxidase (GPx), catalase, Cu,Zn-superoxide dismutase (Cu,Zn-SOD) and heme oxygenase-1 (HO-1) increased with curcumin concentration and also with increase in time of incubation, the expression of Mn- superoxide dismutase (Mn-SOD) showed concentration dependant repression upon treatment with curcumin.	Curcumin	148-156	heme oxygenase 1	Homo sapiens	127-131
31145652-7	2019	Then, we identified that curcumin upregulated the expression of self-renewal genes, Notch1 and Hes1, and augmentation of CDK4, Cyclin D1, NICD, and Hes1 protein.	Curcumin	25-33	notch 1	Mus musculus	84-90
30484020-0	2019	Curcumin Reverses 5-Fluorouracil Resistance by Promoting Human Colon Cancer HCT-8/5-FU Cell Apoptosis and Down-regulating Heat Shock Protein 27 and P-Glycoprotein.	Curcumin	0-8	heat shock protein family B (small) member 1	Homo sapiens	122-143
18720192-1	2009	Curcumin was investigated as an inhibitor of glycogen synthase kinase-3beta (GSK-3beta) in an attempt to explain some of its interesting multiple pharmacological effects, such as its anti-diabetic, anti-inflammatory, anti-cancer, anti-malarial and anti-alzheimer"s properties.	Curcumin	0-8	glycogen synthase kinase 3 beta	Mus musculus	45-75
19539560-0	2009	Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production.	Curcumin	61-69	interleukin 17A	Rattus norvegicus	102-107
18762247-5	2008	Furthermore, curcumin-induced ROS generation leads to the induction of the proapoptotic protein p53 and its effector protein p21 and down-regulation of cell cycle regulatory proteins such as Rb and cyclin D1 and D3.	Curcumin	13-21	transformation related protein 53, pseudogene	Mus musculus	96-99
30484020-15	2019	Down-regulation of P-gp and HSP-27 may be the mechanism of curcumin reversing the drug resistance of HCT-8/5-FU to 5-FU.	Curcumin	59-67	heat shock protein family B (small) member 1	Homo sapiens	28-34
19539560-8	2009	Furthermore, the mRNA expression of the cytokine profiles was assessed by quantitative reverse-transcription polymerase chain reaction (qRT-PCR), revealing the dramatic decrease of IL-17, TGF-beta, IL-6, IL-21, STAT3, and RORgammat expression in curcumin-treated groups and STAT3-phosphorylation also was inhibited.	Curcumin	246-254	interleukin 17A	Rattus norvegicus	181-186
19539560-9	2009	These findings indicated that curcumin amelioration EAE was, to a large extent, due to inhibit differentiation and development of Th17 cells depends on down-regulating expression of IL-6, IL-21, RORgammat signaling and inhibition STAT3-phosphorylation, suggests it is useful in the treatment of MS and other Th17 cell-mediated inflammatory diseases.	Curcumin	30-38	signal transducer and activator of transcription 3	Rattus norvegicus	230-235
18214481-0	2008	Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells.	Curcumin	0-8	aquaporin 3 (Gill blood group)	Homo sapiens	32-36
18214481-7	2008	We also find that curcumin, a well known anti-ovarian cancer drug, down-regulates AQP3 expression and reduces cell migration in CaOV3, and the effects of curcumin are mediated, at least in part, by its inhibitory effects on EGFR and downstream AKT/ERK activation.	Curcumin	18-26	aquaporin 3 (Gill blood group)	Homo sapiens	82-86
30859861-5	2019	Curcumin attenuated PA-induced reduction in cell viability and activation of apoptosis, Caspase 3 activity, BAX, CHOP, and GRP78 expression.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	108-111
18214481-7	2008	We also find that curcumin, a well known anti-ovarian cancer drug, down-regulates AQP3 expression and reduces cell migration in CaOV3, and the effects of curcumin are mediated, at least in part, by its inhibitory effects on EGFR and downstream AKT/ERK activation.	Curcumin	154-162	aquaporin 3 (Gill blood group)	Homo sapiens	82-86
18214481-9	2008	The results that curcumin inhibits EGF-induced up-regulation of AQP3 and cell migration, provide a new explanation for the anticancer potential of curcumin.	Curcumin	17-25	aquaporin 3 (Gill blood group)	Homo sapiens	64-68
19076306-7	2009	In most of the regions examined, histone H3 acetylation peaked 24 h after UVR and then returned to baseline levels by 72 h. The induction of ATF3, COX2 and MKP1 was blocked in the presence of curcumin at doses that decrease in vivo histone H3 acetylation but not at lower doses that do not affect acetylation levels.	Curcumin	192-200	activating transcription factor 3	Homo sapiens	141-145
19771847-3	2009	RESULTS: The suppressive effect of curcumin was shown as a dose dependent and a time dependent manner,and the IC50 was 22.48 micromol/L 40 micromol/L curcumin inhibited the expression of p-ERK, p-NF-kappaB and p-p38, but not p-JNK.	Curcumin	35-43	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	187-192
19771847-3	2009	RESULTS: The suppressive effect of curcumin was shown as a dose dependent and a time dependent manner,and the IC50 was 22.48 micromol/L 40 micromol/L curcumin inhibited the expression of p-ERK, p-NF-kappaB and p-p38, but not p-JNK.	Curcumin	150-158	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	187-192
18214481-9	2008	The results that curcumin inhibits EGF-induced up-regulation of AQP3 and cell migration, provide a new explanation for the anticancer potential of curcumin.	Curcumin	147-155	aquaporin 3 (Gill blood group)	Homo sapiens	64-68
18852135-4	2008	In addition, curcumin treatment of Burkitt"s lymphoma cell lines also causes up-regulation of DR5; however, this up-regulation does not result in apoptosis.	Curcumin	13-21	TNF receptor superfamily member 10b	Homo sapiens	94-97
18384098-4	2008	Curcumin can also activate apoptosis, down-regulate cell survival gene products, and up-regulate p53, p21, and p27.	Curcumin	0-8	H3 histone pseudogene 16	Homo sapiens	102-105
30859861-5	2019	Curcumin attenuated PA-induced reduction in cell viability and activation of apoptosis, Caspase 3 activity, BAX, CHOP, and GRP78 expression.	Curcumin	0-8	DNA-damage inducible transcript 3	Rattus norvegicus	113-117
18384098-4	2008	Curcumin can also activate apoptosis, down-regulate cell survival gene products, and up-regulate p53, p21, and p27.	Curcumin	0-8	interferon alpha inducible protein 27	Homo sapiens	111-114
30859861-7	2019	Both curcumin and 4-PBA also attenuated PA-induced increase in ER stress protein (CHOP and GRP78) expression.	Curcumin	5-13	DNA-damage inducible transcript 3	Rattus norvegicus	82-86
21479462-6	2008	In this study, we demonstrate that curcumin (diferuloylmethane) abrogates OPN-induced VEGF expression and curbs OPN-induced VEGF-dependent breast tumor angiogenesis in vivo.	Curcumin	35-43	secreted phosphoprotein 1	Homo sapiens	74-77
21479462-6	2008	In this study, we demonstrate that curcumin (diferuloylmethane) abrogates OPN-induced VEGF expression and curbs OPN-induced VEGF-dependent breast tumor angiogenesis in vivo.	Curcumin	35-43	secreted phosphoprotein 1	Homo sapiens	112-115
19302828-7	2009	Moreover, curcumin enhanced AC activity and cAMP levels in platelet and various brain regions, and up-regulated mRNA expressions of AC subtypes AC 2, AC 8 and cAMP response element binding protein (CREB) in the hippocampus, cortex and hypothalamus of the CUMS rats.	Curcumin	10-18	cAMP responsive element binding protein 1	Rattus norvegicus	159-196
31204416-2	2019	The aim of the current study was to evaluate the effect of phytosomal curcumin on serum adiponectin and leptin levels in patients with NAFLD.	Curcumin	70-78	leptin	Homo sapiens	104-110
19302828-7	2009	Moreover, curcumin enhanced AC activity and cAMP levels in platelet and various brain regions, and up-regulated mRNA expressions of AC subtypes AC 2, AC 8 and cAMP response element binding protein (CREB) in the hippocampus, cortex and hypothalamus of the CUMS rats.	Curcumin	10-18	cAMP responsive element binding protein 1	Rattus norvegicus	198-202
19302828-9	2009	These results suggested that the potent antidepressant property of curcumin might be attributed to its improvement of AC-cAMP pathway as well as CREB via suppressing central 5-HT(1A/1B/7) receptors in the CUMS rats.	Curcumin	67-75	cAMP responsive element binding protein 1	Rattus norvegicus	145-149
21479462-6	2008	In this study, we demonstrate that curcumin (diferuloylmethane) abrogates OPN-induced VEGF expression and curbs OPN-induced VEGF-dependent breast tumor angiogenesis in vivo.	Curcumin	45-62	secreted phosphoprotein 1	Homo sapiens	74-77
21479462-6	2008	In this study, we demonstrate that curcumin (diferuloylmethane) abrogates OPN-induced VEGF expression and curbs OPN-induced VEGF-dependent breast tumor angiogenesis in vivo.	Curcumin	45-62	secreted phosphoprotein 1	Homo sapiens	112-115
21479462-8	2008	Our results indicate that curcumin suppresses OPN-induced VEGF expression and tumor angiogenesis, and suggest that this study may aid in the development of a curcumin-based OPN-targeted therapeutic approach to the control of breast tumor angiogenesis.	Curcumin	26-34	secreted phosphoprotein 1	Homo sapiens	46-49
21479462-8	2008	Our results indicate that curcumin suppresses OPN-induced VEGF expression and tumor angiogenesis, and suggest that this study may aid in the development of a curcumin-based OPN-targeted therapeutic approach to the control of breast tumor angiogenesis.	Curcumin	26-34	secreted phosphoprotein 1	Homo sapiens	173-176
21479462-8	2008	Our results indicate that curcumin suppresses OPN-induced VEGF expression and tumor angiogenesis, and suggest that this study may aid in the development of a curcumin-based OPN-targeted therapeutic approach to the control of breast tumor angiogenesis.	Curcumin	158-166	secreted phosphoprotein 1	Homo sapiens	46-49
31204416-6	2019	Serum adiponectin levels increased significantly (p&lt;0.001) and serum leptin levels decreased significantly (p&lt;0.001) with a decrease in the leptin: adiponectin ratio in the curcumin group compared to the placebo group after 8 weeks of intervention.	Curcumin	179-187	leptin	Homo sapiens	146-152
21479462-8	2008	Our results indicate that curcumin suppresses OPN-induced VEGF expression and tumor angiogenesis, and suggest that this study may aid in the development of a curcumin-based OPN-targeted therapeutic approach to the control of breast tumor angiogenesis.	Curcumin	158-166	secreted phosphoprotein 1	Homo sapiens	173-176
18704882-0	2008	Curcumin up-regulates LDL receptor expression via the sterol regulatory element pathway in HepG2 cells.	Curcumin	0-8	low density lipoprotein receptor	Homo sapiens	22-34
19272793-8	2009	These effects were blocked by the JAK inhibitor, AG490 and by the STAT3 inhibitor Curcumin, but not by the MAPK inhibitor, PD98059, nor by the PI3K inhibitor, Wortmannin.	Curcumin	82-90	signal transducer and activator of transcription 3	Rattus norvegicus	66-71
18704882-4	2008	Herein, we investigated the effect of curcumin on LDL-R expression and its molecular mechanism in HepG2 cells.	Curcumin	38-46	low density lipoprotein receptor	Homo sapiens	50-55
31204416-8	2019	Phytosomal curcumin effectively improved leptin and adiponectin levels.	Curcumin	11-19	leptin	Homo sapiens	41-47
18704882-5	2008	Curcumin increased LDL-R expression (mRNA and protein) and the resultant uptake of DiI-LDL in a dose- and time-dependent manner.	Curcumin	0-8	low density lipoprotein receptor	Homo sapiens	19-24
19350453-2	2009	Curcumin, a promising chemotherapeutic agent, inhibits human GSTA1-1, GSTM1-1, and GSTP1-1 isoenzymes.	Curcumin	0-8	glutathione S-transferase pi 1	Homo sapiens	83-90
31092832-0	2019	Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFkB/AKT/mTOR/KEAP1 signalling in rat heart.	Curcumin	41-49	nuclear factor kappa B subunit 1	Rattus norvegicus	111-115
19350453-4	2009	Most of the 34 curcumin analogues showed less potent inhibitory activities towards GSTA1-1, GSTM1-1, and GSTP1-1 than the parent curcumin.	Curcumin	15-23	glutathione S-transferase pi 1	Homo sapiens	105-112
19350453-4	2009	Most of the 34 curcumin analogues showed less potent inhibitory activities towards GSTA1-1, GSTM1-1, and GSTP1-1 than the parent curcumin.	Curcumin	129-137	glutathione S-transferase pi 1	Homo sapiens	105-112
19294764-6	2009	The expression of PPARdelta, 14-3-3epsilon and VEGF was reduced and the activity of beta-catenin/Tcf-4 signaling was inhibited by curcumin treatment.	Curcumin	130-138	catenin beta 1	Homo sapiens	84-96
18704882-6	2008	Using a GFP reporter system in a transfected HepG2/SRE-GFP cell line, we found that curcumin activated the sterol regulatory element of the LDL-R promoter.	Curcumin	84-92	low density lipoprotein receptor	Homo sapiens	140-145
18704882-7	2008	In HepG2/Insig2 cells, curcumin reversed the inhibition of LDL-R expression induced by Insig2 overexpression.	Curcumin	23-31	low density lipoprotein receptor	Homo sapiens	59-64
18704882-8	2008	These data demonstrate that curcumin increases LDL-R protein expression and uptake activity via the SREBPs pathway.	Curcumin	28-36	low density lipoprotein receptor	Homo sapiens	47-52
31091659-10	2019	Modeling of mTOR protein revealed structural changes upon treatments, and curcumin plus GR decreased binding of Raptor and GbetaL to mTOR, as well as of Rag A and Rag B to Raptor.	Curcumin	74-82	Ras related GTP binding A	Homo sapiens	153-158
18685195-1	2008	Curcumin analogs were first investigated for their inhibitory effects on thioredoxin reductase (TrxR).	Curcumin	0-8	peroxiredoxin 5	Homo sapiens	96-100
31080349-0	2019	Curcumin modulates the apolipoprotein B mRNA editing by coordinating the expression of cytidine deamination to uridine editosome components in primary mouse hepatocytes.	Curcumin	0-8	apolipoprotein B	Mus musculus	23-39
31080349-3	2019	However, the role of curcumin in the regulation of apoB mRNA editing is not clear.	Curcumin	21-29	apolipoprotein B	Mus musculus	51-55
31080349-4	2019	Thus, we investigated the effect of curcumin on the expression of multiple editing components of apoB mRNA cytidine deamination to uridine (C-to-U) editosome.	Curcumin	36-44	apolipoprotein B	Mus musculus	97-101
31080349-6	2019	Moreover, the increased apoB RNA editing by 50 microM curcumin was significantly reduced by siRNA-mediated APOBEC-1, ACF, and RBM47 knockdown.	Curcumin	54-62	apolipoprotein B	Mus musculus	24-28
31080349-7	2019	These findings suggest that curcumin modulates apoB mRNA editing by coordinating the multiple editing components of the editosome in primary hepatocytes.	Curcumin	28-36	apolipoprotein B	Mus musculus	47-51
31278718-8	2019	Co-treatment with curcumin or taurine with BPA led to reduce in MDA and increased GPx, GST, CAT, SOD activities compared to BPA group.	Curcumin	18-26	hematopoietic prostaglandin D synthase	Rattus norvegicus	87-90
18660423-12	2008	In addition, curcumin significantly (P &lt; 0.001) decreased SDF-1alpha-induced HRECs migration and downregulated SDF-1alpha-induced expression of CXCR4, phospho-AKT, phospho-phosphatidylinositol-3-kinase (PI3-K), and eNOS.	Curcumin	13-21	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	167-204
19112904-1	2008	OBJECTIVE: To investigate the effect of curcumin on indoleamine 2, 3 -dioxygenase (IDO) expression induced by IFN-gamma in cancer cells.	Curcumin	40-48	indoleamine 2,3-dioxygenase 1	Homo sapiens	83-86
19112904-3	2008	The effects of curcumin on IDO expression induced by IFN-gamma in these cancer cells were demonstrated by Western blot.	Curcumin	15-23	indoleamine 2,3-dioxygenase 1	Homo sapiens	27-30
19112904-4	2008	The transcription of interferon responsive factor-1 (IRF-1), which was a key transcription factor regulating IDO expression, was analyzed by reverse transcription polymerase chain reaction (RT-PCR) under the treatment of curcumin.	Curcumin	221-229	indoleamine 2,3-dioxygenase 1	Homo sapiens	109-112
19013780-5	2009	CAPE, curcumin, and trans-ferulic acid markedly enhanced the adiponectin secretion of 3T3-L1 adipocytes, but not gamma-oryzanol.	Curcumin	6-14	adiponectin, C1Q and collagen domain containing	Mus musculus	61-72
19228728-8	2009	Moreover, curcumin suppressed expression of the anti-apoptotic proteins Mcl-1 and X-linked inhibitor of apoptosis protein (XIAP), and up-regulated the pro-apoptotic protein BIM.	Curcumin	10-18	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	72-77
19075017-0	2009	Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase Cdelta-STAT1 signaling pathway in interferon-gamma-stimulated murine dendritic cells.	Curcumin	0-8	indoleamine 2,3-dioxygenase 1	Mus musculus	37-64
19112904-5	2008	RESULTS: Curcumin inhibited the expression of IDO in these cancer cells.	Curcumin	9-17	indoleamine 2,3-dioxygenase 1	Homo sapiens	46-49
19075017-5	2009	In addition, we demonstrate that curcumin, an active component of turmeric, significantly inhibited the induction of IDO expression and activity by IFNgamma.	Curcumin	33-41	indoleamine 2,3-dioxygenase 1	Mus musculus	117-120
19112904-7	2008	CONCLUSION: Curcumin could inhibit the expression of IDO in cancer cells.	Curcumin	12-20	indoleamine 2,3-dioxygenase 1	Homo sapiens	53-56
30671976-13	2019	The proportion of patients with PSA progression during the active curcumin treatment period (6 months) was significantly lower in the curcumin group than the placebo group (10.3% vs 30.2%, P = 0.0259).	Curcumin	134-142	aminopeptidase puromycin sensitive	Homo sapiens	32-35
18565277-8	2008	The platelets activated with thrombin and BMECs stimulated by TNF-alpha demonstrated an upregulated expressions of P-selectin and E-selectin, and this increase, when pretreated with curcumin for 30 min, could be restrained dose dependently.	Curcumin	182-190	selectin P	Homo sapiens	115-125
18565277-8	2008	The platelets activated with thrombin and BMECs stimulated by TNF-alpha demonstrated an upregulated expressions of P-selectin and E-selectin, and this increase, when pretreated with curcumin for 30 min, could be restrained dose dependently.	Curcumin	182-190	selectin E	Homo sapiens	130-140
19075017-6	2009	We found that curcumin suppressed STAT1 activation by directly inhibiting Janus-activated kinase 1/2 and protein kinase Cdelta phosphorylation in bone marrow-derived DCs, suppressing the subsequent translocation and binding of STAT1 to the GAS element of the IRF-1 promoter.	Curcumin	14-22	interferon regulatory factor 1	Mus musculus	259-264
19075017-7	2009	Coincident with these inhibitory effects on IFNgamma-induced IDO expression, curcumin reversed IDO-mediated suppression of T-cell responses.	Curcumin	77-85	indoleamine 2,3-dioxygenase 1	Mus musculus	95-98
19075017-8	2009	Our results, thus, suggest that down-regulation of IDO in DCs is an important immunomodulatory property of curcumin that may be exploited therapeutically in the control of cancers.	Curcumin	107-115	indoleamine 2,3-dioxygenase 1	Mus musculus	51-54
19095035-10	2009	Transcriptional Hsp70 expression was induced in only young rats and was suppressed by curcumin.	Curcumin	86-94	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	16-21
18403477-4	2008	Curcumin treatment also significantly reduced macrophage infiltration of white adipose tissue, increased adipose tissue adiponectin production, and decreased hepatic nuclear factor-kappaB activity, hepatomegaly, and markers of hepatic inflammation.	Curcumin	0-8	adiponectin, C1Q and collagen domain containing	Mus musculus	120-131
19002562-1	2009	Curcumin, an active ingredient of Curcumin longa mediates its anti-inflammatory effects through inhibition of NFkB.	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	110-114
30671976-18	2019	However, PSA elevation was suppressed with curcumin intake during the curcumin administration period.	Curcumin	43-51	aminopeptidase puromycin sensitive	Homo sapiens	9-12
19002562-1	2009	Curcumin, an active ingredient of Curcumin longa mediates its anti-inflammatory effects through inhibition of NFkB.	Curcumin	34-42	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	110-114
19002562-3	2009	In this study, we investigated the effects of curcumin on the expression of TLR-4 and MyD88, the upstream signaling pathway in experimental colitis induced in the Sprague-Dawley male rats by intra-rectal administration of trinitrobenzenesulfonic acid (TNBS).	Curcumin	46-54	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	86-91
19002562-9	2009	TNBS-induced increase in the level of MPO activity and MDA concentrations was reversed by curcumin treatment, whereas the same dose of curcumin did not affect their levels in the non-colitis animals.	Curcumin	90-98	myeloperoxidase	Rattus norvegicus	38-41
18386790-4	2008	Curcumin is incorporated into H-RS cells and acts inhibiting both NF-kappaB and STAT3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1, survivin, c-myc and cyclin D1.	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	241-246
18386790-6	2008	Furthermore, curcumin triggered cell death by apoptosis, as evidenced by the activation of caspase-3 and caspase-9, changes in nuclear morphology and phosphatidylserine translocation.	Curcumin	13-21	caspase 9	Homo sapiens	105-114
30671976-18	2019	However, PSA elevation was suppressed with curcumin intake during the curcumin administration period.	Curcumin	70-78	aminopeptidase puromycin sensitive	Homo sapiens	9-12
30987250-0	2019	The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells.	Curcumin	17-25	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	51-54
18417733-5	2008	Despite these similarities, only curcumin was effective in reducing amyloid plaque burden, insoluble beta-amyloid peptide (Abeta), and carbonyls.	Curcumin	33-41	amyloid beta (A4) precursor protein	Mus musculus	123-128
19002562-10	2009	Increases in the levels of TLR-4, MyD88, and NFkB proteins in inflamed tissue were also suppressed significantly by curcumin treatment.	Curcumin	116-124	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	34-39
31002157-0	2019	Over-expression of DJ-1 attenuates effects of curcumin on colorectal cancer cell proliferation and apoptosis.	Curcumin	46-54	Parkinsonism associated deglycase	Homo sapiens	19-23
19002562-10	2009	Increases in the levels of TLR-4, MyD88, and NFkB proteins in inflamed tissue were also suppressed significantly by curcumin treatment.	Curcumin	116-124	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	45-49
19002562-12	2009	These findings demonstrate that signaling pathway of curcumin-induced inhibition of inflammation involves TLR-4 and MyD88, and therefore may serve as an important therapeutic target in IBD.	Curcumin	53-61	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	116-121
18841445-6	2009	Curcumin inhibited ABCG2 activity at nanomolar concentrations at the rat blood-brain barrier in the ex vivo assay.	Curcumin	0-8	ATP binding cassette subfamily G member 2	Rattus norvegicus	19-24
18423603-0	2008	Curcumin induces apoptosis in HCT-116 human colon cancer cells in a p21-independent manner.	Curcumin	0-8	H3 histone pseudogene 16	Homo sapiens	68-71
18423603-3	2008	Several studies report that curcumin inhibits cancer cell proliferation and induces apoptosis in cancer cells through p21-mediated cell cycle arrest.	Curcumin	28-36	H3 histone pseudogene 16	Homo sapiens	118-121
18423603-5	2008	In this study, we determined whether curcumin-induced cytotoxicity in cultures of HCT-116 human colon cancer cells was dependent on p21 status.	Curcumin	37-45	H3 histone pseudogene 16	Homo sapiens	132-135
18423603-7	2008	Moreover, an equivalent cytotoxic effect by curcumin was observed in both p21(+/+) and p21(-/-)HCT-116 cells, indicating that curcumin-induced cytotoxicity was p21-independent.	Curcumin	44-52	H3 histone pseudogene 16	Homo sapiens	74-77
18423603-7	2008	Moreover, an equivalent cytotoxic effect by curcumin was observed in both p21(+/+) and p21(-/-)HCT-116 cells, indicating that curcumin-induced cytotoxicity was p21-independent.	Curcumin	44-52	H3 histone pseudogene 16	Homo sapiens	87-90
18423603-7	2008	Moreover, an equivalent cytotoxic effect by curcumin was observed in both p21(+/+) and p21(-/-)HCT-116 cells, indicating that curcumin-induced cytotoxicity was p21-independent.	Curcumin	44-52	H3 histone pseudogene 16	Homo sapiens	87-90
18423603-9	2008	Western blot analysis showed that cell death in curcumin-treated cultures of p21(+/+) and p21(-/-) HCT-116 cells was associated with a reduction in pro-caspase-3 and PARP-1 cleavage, which are indicative of apoptosis.	Curcumin	48-56	H3 histone pseudogene 16	Homo sapiens	77-80
18423603-9	2008	Western blot analysis showed that cell death in curcumin-treated cultures of p21(+/+) and p21(-/-) HCT-116 cells was associated with a reduction in pro-caspase-3 and PARP-1 cleavage, which are indicative of apoptosis.	Curcumin	48-56	H3 histone pseudogene 16	Homo sapiens	90-93
30816425-1	2019	The aim of the present study was to investigate the protective effects of curcumin and its effect on the methyl ethyl ketone/extracellular signal regulated kinase/cAMP-response element binding protein (MEK/ERK/CREB) pathway.	Curcumin	74-82	cAMP responsive element binding protein 1	Rattus norvegicus	210-214
19110321-2	2009	Extensive research within the past two decades has shown that curcumin mediates its anti-inflammatory effects through the downregulation of inflammatory transcription factors (such as nuclear factor kappaB), enzymes (such as cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as tumor necrosis factor, interleukin 1 and interleukin 6).	Curcumin	62-70	interleukin 1 alpha	Homo sapiens	308-339
30816425-10	2019	Curcumin was demonstrated to improve nerve damage symptoms and infarct volume, reduce brain water content, relieve neuronal apoptosis and also increase the expression of p-MEK, p-ERK, p-CREB, Bcl-2 and reduce Bax levels in vivo and in vitro.	Curcumin	0-8	cAMP responsive element binding protein 1	Rattus norvegicus	186-190
18200517-10	2008	Secretion of IL-4 and IL-5 by CD4(+) lymphocytes of BALB/c mice but not SJL/J mice was significantly augmented by ConA and reduced to control levels by curcumin.	Curcumin	152-160	interleukin 4	Mus musculus	13-17
30925757-6	2019	Both curcumin and resveratrol down-regulated the level of Toll-like-receptor 4 mRNA and protein expression in the intestine to inhibit the release of critical inflammation molecules (interleukin-1beta, tumor necrosis factor-alpha), and increase the secretion of immunoglobulin.	Curcumin	5-13	toll like receptor 4	Homo sapiens	58-78
18200517-10	2008	Secretion of IL-4 and IL-5 by CD4(+) lymphocytes of BALB/c mice but not SJL/J mice was significantly augmented by ConA and reduced to control levels by curcumin.	Curcumin	152-160	interleukin 5	Mus musculus	22-26
18357586-0	2008	Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes.	Curcumin	58-66	heme oxygenase 1	Homo sapiens	0-16
18357586-1	2008	Curcumin, a polyphenolic compound derived from plant, regulates heme oxygenase (HO-1) expression within certain cell types; however, the Curcumin-mediated signal transduction in the regulation of HO-1 expression within human monocytes/macrophages is unclear.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	80-84
18357586-1	2008	Curcumin, a polyphenolic compound derived from plant, regulates heme oxygenase (HO-1) expression within certain cell types; however, the Curcumin-mediated signal transduction in the regulation of HO-1 expression within human monocytes/macrophages is unclear.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	196-200
18357586-1	2008	Curcumin, a polyphenolic compound derived from plant, regulates heme oxygenase (HO-1) expression within certain cell types; however, the Curcumin-mediated signal transduction in the regulation of HO-1 expression within human monocytes/macrophages is unclear.	Curcumin	137-145	heme oxygenase 1	Homo sapiens	80-84
18357586-1	2008	Curcumin, a polyphenolic compound derived from plant, regulates heme oxygenase (HO-1) expression within certain cell types; however, the Curcumin-mediated signal transduction in the regulation of HO-1 expression within human monocytes/macrophages is unclear.	Curcumin	137-145	heme oxygenase 1	Homo sapiens	196-200
18357586-2	2008	Herein, we show that Curcumin dose dependently induced HO-1 expression and HO-1 activity through the activation of PKCalpha, PKCdelta/ERK1/2, p38alpha, and PI3-kinase.	Curcumin	21-29	heme oxygenase 1	Homo sapiens	55-59
18357586-2	2008	Herein, we show that Curcumin dose dependently induced HO-1 expression and HO-1 activity through the activation of PKCalpha, PKCdelta/ERK1/2, p38alpha, and PI3-kinase.	Curcumin	21-29	heme oxygenase 1	Homo sapiens	75-79
18357586-3	2008	In addition, H2O2 release is essential for Curcumin-mediated ERK1/2 and p38 phosphorylation and HO-1 expression.	Curcumin	43-51	heme oxygenase 1	Homo sapiens	96-100
19028451-5	2009	IL-8 up-regulation in response to HSP90 was also attenuated by IkappaB, rasveratrol, curcumin, diphenyleneiodium, N-acetylcystein, U0126, and SB202190.	Curcumin	85-93	heat shock protein 90 alpha family class A member 1	Homo sapiens	34-39
18815282-6	2009	Curcumin repressed synthesis of hepcidin, a peptide that plays a central role in regulation of systemic iron balance.	Curcumin	0-8	hepcidin antimicrobial peptide	Homo sapiens	32-40
30925757-7	2019	Our results suggested that curcumin and resveratrol can regulate weaned piglet gut microbiota, down-regulate the TLR4 signaling pathway, alleviate intestinal inflammation, and ultimately increase intestinal immune function.	Curcumin	27-35	toll like receptor 4	Homo sapiens	113-117
30717973-7	2019	Moreover, we found that curcumin could regulate XIST/miR-106b-5p/P21 axis in RCC cells.	Curcumin	24-32	X inactive specific transcript	Homo sapiens	48-52
19331178-6	2009	RESULTS: Curcumin together with BM-ANF1 produced a greater inhibition of HCT-116 cells growth than either agent alone, attributable to the inhibition of proliferation and stimulation of apoptosis, as evidenced by suppression of proliferating cell nuclear antigen (PCNA) expression, cell cycle arrest at the G2/M-phase and caspase-3 activation.	Curcumin	9-17	proliferating cell nuclear antigen	Homo sapiens	228-262
19331178-6	2009	RESULTS: Curcumin together with BM-ANF1 produced a greater inhibition of HCT-116 cells growth than either agent alone, attributable to the inhibition of proliferation and stimulation of apoptosis, as evidenced by suppression of proliferating cell nuclear antigen (PCNA) expression, cell cycle arrest at the G2/M-phase and caspase-3 activation.	Curcumin	9-17	proliferating cell nuclear antigen	Homo sapiens	264-268
18430363-0	2008	Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells.	Curcumin	0-8	sterol regulatory element binding transcription factor 1	Mus musculus	66-73
18430363-0	2008	Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells.	Curcumin	0-8	caveolin 1, caveolae protein	Mus musculus	74-84
18430363-7	2008	d(-1 )curcumin to apoE-/- mice for 4 months induced a 50% reduction of atherosclerotic lesions and yielded a 5- fold increase in the caveolin-1 expression level as compared to the model group.	Curcumin	6-14	caveolin 1, caveolae protein	Mus musculus	133-143
18430363-9	2008	Lipid-loaded cells exposed to curcumin at various concentrations (12.5, 25, and 50 micromol/L) for different durations (0, 6, 12, 24, and 48 h) significantly diminished the number and area of cellular lipid droplets, total cholesterol, cholesterol ester, and free cholesterol accompanying the elevation of the caveolin-1 expression level (approximately 3-fold); the translocation of SREBP-1 from the cytoplasm to the nucleus was inhibited compared with the models.	Curcumin	30-38	caveolin 1, caveolae protein	Mus musculus	310-320
18430363-9	2008	Lipid-loaded cells exposed to curcumin at various concentrations (12.5, 25, and 50 micromol/L) for different durations (0, 6, 12, 24, and 48 h) significantly diminished the number and area of cellular lipid droplets, total cholesterol, cholesterol ester, and free cholesterol accompanying the elevation of the caveolin-1 expression level (approximately 3-fold); the translocation of SREBP-1 from the cytoplasm to the nucleus was inhibited compared with the models.	Curcumin	30-38	sterol regulatory element binding transcription factor 1	Mus musculus	383-390
19177192-0	2009	Dimethoxycurcumin, a Synthetic Curcumin Analogue, Induces Heme Oxygenase-1 Expression through Nrf2 Activation in RAW264.7 Macrophages.	Curcumin	31-39	heme oxygenase 1	Homo sapiens	58-74
30717973-7	2019	Moreover, we found that curcumin could regulate XIST/miR-106b-5p/P21 axis in RCC cells.	Curcumin	24-32	H3 histone pseudogene 16	Homo sapiens	65-68
19177192-2	2009	The aim of this study was to investigate whether dimethoxycurcumin [1,7-bis(4,3-dimethoxyphenyl)-1,6-heptadiene-3,5-dione], a synthetic curcumin analogue with higher metabolic stability over curcumin, could induce HO-1 expression to the same extent as curcumin in RAW264.7 macrophages.	Curcumin	58-66	heme oxygenase 1	Homo sapiens	214-218
19177192-3	2009	Dimethoxycurcumin and curcumin, but not tetrahydrocurcumin, induced HO-1 expression and Nrf2 nuclear translocation, suggesting that the unsaturated nature of the diarylheptanoid chain of the compounds are crucial for HO-1 expression and Nrf2 activation.	Curcumin	9-17	heme oxygenase 1	Homo sapiens	68-72
18098290-0	2008	The combination of epigallocatechin gallate and curcumin suppresses ER alpha-breast cancer cell growth in vitro and in vivo.	Curcumin	48-56	estrogen receptor 1 (alpha)	Mus musculus	68-76
18098290-7	2008	Curcumin treatment significantly decreased tumor protein levels of EGFR and Akt, however the expression of these proteins was not further decreased following combination treatment.	Curcumin	0-8	epidermal growth factor receptor	Mus musculus	67-71
19177192-3	2009	Dimethoxycurcumin and curcumin, but not tetrahydrocurcumin, induced HO-1 expression and Nrf2 nuclear translocation, suggesting that the unsaturated nature of the diarylheptanoid chain of the compounds are crucial for HO-1 expression and Nrf2 activation.	Curcumin	9-17	heme oxygenase 1	Homo sapiens	217-221
30727807-0	2019	Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells.	Curcumin	0-8	microRNA 21	Homo sapiens	23-29
19177192-5	2009	In comparison, dimethoxycurcumin and curcumin had about the same effect on HO-1 expression, suggesting that dimethoxycurcumin retains the HO-1-inducing activity of its parent compound curcumin in RAW264.7 macrophages.	Curcumin	24-32	heme oxygenase 1	Homo sapiens	75-79
19177192-5	2009	In comparison, dimethoxycurcumin and curcumin had about the same effect on HO-1 expression, suggesting that dimethoxycurcumin retains the HO-1-inducing activity of its parent compound curcumin in RAW264.7 macrophages.	Curcumin	37-45	heme oxygenase 1	Homo sapiens	75-79
18098290-8	2008	Therefore, these results demonstrate that the combination of EGCG and curcumin is efficacious in both in vitro and in vivo models of ER alpha-breast cancer and that regulation of VEGFR-1 may play a key role in this effect.	Curcumin	70-78	estrogen receptor 1 (alpha)	Mus musculus	133-141
30727807-0	2019	Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells.	Curcumin	0-8	phosphatase and tensin homolog	Homo sapiens	30-34
18394691-7	2008	Suppression of degranulation and secretion of TNF-alpha and IL-4 was apparent at concentrations as low as 3 micromol/L curcumin in activated mast cells.	Curcumin	119-127	interleukin 4	Mus musculus	60-64
18394691-8	2008	Similar concentrations of curcumin suppressed Syk-dependent phosphorylations of the adaptor proteins linker of activated T cells and Grb2-associated binder 2, which are critical for mast cell activation.	Curcumin	26-34	growth factor receptor bound protein 2-associated protein 2	Mus musculus	133-157
30727807-10	2019	With increasing curcumin levels, PTEN expression increased and miR-21 levels decreased.	Curcumin	16-24	phosphatase and tensin homolog	Homo sapiens	33-37
18332871-0	2008	Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells.	Curcumin	66-74	epidermal growth factor	Homo sapiens	118-121
18332871-2	2008	We previously reported that curcumin, the yellow pigment in curry, interrupted PDGF and EGF signaling, stimulated PPARgamma gene expression, and enhanced its activity, leading to inhibition of cell proliferation of activated HSC in vitro and in vivo.	Curcumin	28-36	epidermal growth factor	Homo sapiens	88-91
30727807-10	2019	With increasing curcumin levels, PTEN expression increased and miR-21 levels decreased.	Curcumin	16-24	microRNA 21	Homo sapiens	63-69
18332871-2	2008	We previously reported that curcumin, the yellow pigment in curry, interrupted PDGF and EGF signaling, stimulated PPARgamma gene expression, and enhanced its activity, leading to inhibition of cell proliferation of activated HSC in vitro and in vivo.	Curcumin	28-36	fucosyltransferase 1 (H blood group)	Homo sapiens	225-228
30727807-11	2019	These results suggest that curcumin negatively modulated the miR-21/PTEN/Akt pathway.	Curcumin	27-35	microRNA 21	Homo sapiens	61-67
30727807-11	2019	These results suggest that curcumin negatively modulated the miR-21/PTEN/Akt pathway.	Curcumin	27-35	phosphatase and tensin homolog	Homo sapiens	68-72
18849546-0	2008	Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via alpha v beta 3 integrins in human gastric cancer cells.	Curcumin	21-29	secreted phosphoprotein 1	Homo sapiens	0-11
30727807-13	2019	Additionally, the inhibitory effects of curcumin on the miR-21/PTEN/Akt pathway were significantly enhanced.	Curcumin	40-48	microRNA 21	Homo sapiens	56-62
18849546-3	2008	Here, we report that curcumin inhibited the growth of SGC7901 cell and induced apoptosis in a concentration- and time-dependent manner, while the acquired expression of OPN in SGC7901 cells dramatically promoted cell survival under serum depletion and prevented curcumin-induced apoptosis.	Curcumin	262-270	secreted phosphoprotein 1	Homo sapiens	169-172
18189141-0	2008	Curcumin inhibits aggregation of alpha-synuclein.	Curcumin	0-8	synuclein alpha	Homo sapiens	33-48
30727807-13	2019	Additionally, the inhibitory effects of curcumin on the miR-21/PTEN/Akt pathway were significantly enhanced.	Curcumin	40-48	phosphatase and tensin homolog	Homo sapiens	63-67
18189141-3	2008	Reasoning that oligomerization kinetics and mechanism of amyloid formation are similar in Parkinson"s disease (PD) and AD, we investigated the effect of curcumin on alpha-synuclein (AS) protein aggregation.	Curcumin	153-161	synuclein alpha	Homo sapiens	165-180
18189141-3	2008	Reasoning that oligomerization kinetics and mechanism of amyloid formation are similar in Parkinson"s disease (PD) and AD, we investigated the effect of curcumin on alpha-synuclein (AS) protein aggregation.	Curcumin	153-161	synuclein alpha	Homo sapiens	182-184
30668434-9	2019	Our results also supported the involvement of p53-p21 axis in the anticancer effects of curcumin and PTX.	Curcumin	88-96	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	46-49
18189141-5	2008	It was observed that the addition of curcumin inhibited aggregation in a dose-dependent manner and increased AS solubility.	Curcumin	37-45	synuclein alpha	Homo sapiens	109-111
18189141-10	2008	Greater than 32% decrease in mutant alpha-synuclein aggregation was observed within 48 h subsequent to curcumin addition.	Curcumin	103-111	synuclein alpha	Homo sapiens	36-51
18189141-11	2008	Our data suggest that curcumin inhibits AS oligomerization into higher molecular weight aggregates and therefore should be further explored as a potential therapeutic compound for PD and related disorders.	Curcumin	22-30	synuclein alpha	Homo sapiens	40-42
19055861-10	2008	Using western blots and transcription factors arrays, we showed that curcumin decreased NF-kappaB levels and increased p53 levels.	Curcumin	69-77	transformation related protein 53, pseudogene	Mus musculus	119-122
30863383-0	2019	The Antimicrobials Anacardic Acid and Curcumin Are Not-Competitive Inhibitors of Gram-Positive Bacterial Pathogenic Glyceraldehyde-3-Phosphate Dehydrogenase by a Mechanism Unrelated to Human C5a Anaphylatoxin Binding.	Curcumin	38-46	complement C5	Homo sapiens	191-208
19192720-3	2008	In the present study, we demonstrate that curcumin and TRAIL combination regimen is also the most effective treatment for inhibiting the growth of PC3 xenografts compared to curcumin or TRAIL monotherpy.	Curcumin	42-50	chromobox 8	Homo sapiens	147-150
19192720-3	2008	In the present study, we demonstrate that curcumin and TRAIL combination regimen is also the most effective treatment for inhibiting the growth of PC3 xenografts compared to curcumin or TRAIL monotherpy.	Curcumin	174-182	chromobox 8	Homo sapiens	147-150
30838091-10	2019	Western blot analysis suggest, curcumin induce apoptosis through the activation of caspase 9, 6, 12, PARP, CHOP and PTEN.	Curcumin	31-39	caspase 9	Homo sapiens	83-92
30838091-10	2019	Western blot analysis suggest, curcumin induce apoptosis through the activation of caspase 9, 6, 12, PARP, CHOP and PTEN.	Curcumin	31-39	phosphatase and tensin homolog	Homo sapiens	116-120
18983524-8	2008	Inhibition of heme-induced TF mRNA expression by sulfasalazine and curcumin suggested that the transcription factor nuclear factor kappaB is involved in mediating heme-induced TF expression in endothelial cells.	Curcumin	67-75	coagulation factor III, tissue factor	Homo sapiens	27-29
30838091-12	2019	Interestingly, cleaved caspase 9 was activated in higher amount in nano-conjugated curcumin compared to the free curcumin.	Curcumin	83-91	caspase 9	Homo sapiens	23-32
18983524-8	2008	Inhibition of heme-induced TF mRNA expression by sulfasalazine and curcumin suggested that the transcription factor nuclear factor kappaB is involved in mediating heme-induced TF expression in endothelial cells.	Curcumin	67-75	coagulation factor III, tissue factor	Homo sapiens	176-178
17949793-12	2008	Furthermore, antioxidant curcumin dramatically inhibited CRP-induced PAI-1 mRNA expression.	Curcumin	25-33	serpin family E member 1	Homo sapiens	69-74
30838091-12	2019	Interestingly, cleaved caspase 9 was activated in higher amount in nano-conjugated curcumin compared to the free curcumin.	Curcumin	113-121	caspase 9	Homo sapiens	23-32
30838091-13	2019	But other ER resident protein like IRE1alpha, PERK and GRP78 were downregulated indicating curcumin disturbs ER homeostasis.	Curcumin	91-99	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	46-50
30611528-7	2019	The results showed that curcumin can suppresses adipocyte differentiation in a dose-dependent manner and inhibited the expression of PPARgamma, C/EBPalpha, and FABP4.	Curcumin	24-32	fatty acid binding protein 4	Homo sapiens	160-165
18719352-5	2008	Exposure to curcumin led to dose-dependent suppression of osteoclastogenesis in the coculture system, and to reduced expression of RANKL in IL-1alpha-stimulated BMSCs.	Curcumin	12-20	interleukin 1 alpha	Homo sapiens	140-149
30840308-10	2019	Moreover, curcumin also decreased the expression of HIF-1alpha downstream genes, VEGF, HMOX1, ROS and PDGF.	Curcumin	10-18	heme oxygenase 1	Homo sapiens	87-92
20020854-6	2008	Cells were pretreated with the AP-1 inhibitor curcumin (10, 25, 50 muM), and silica-induced PAI-1 expression was reduced by 20%, 63%, and 65%, respectively.	Curcumin	46-54	serpin family E member 1	Homo sapiens	92-97
17975885-0	2007	Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in Caco-2 cells.	Curcumin	68-76	glutathione S-transferase kappa 1	Homo sapiens	6-31
30346064-4	2019	In short-term experiments, the combination of UA + Curc given topically prior to 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited activation of epidermal EGFR, p70S6K, NF-kappaB p50, Src, c-Jun, Rb, and IkappaBalpha.	Curcumin	51-55	Rous sarcoma oncogene	Mus musculus	201-204
17701891-3	2007	We previously showed that curcumin supplementation could abrogate ER retention and aggregation-induced apoptosis associated with neuropathy-causing MPZ mutants.	Curcumin	26-34	myelin protein zero	Mus musculus	148-151
17532108-8	2007	The activities of kidney cortex enzymes, aminopeptidase N, angiotensinase A and dipeptidyl peptidase IV, were reduced in glycerol as well as in curcumin treated rats.	Curcumin	144-152	alanyl aminopeptidase, membrane	Rattus norvegicus	41-57
30461085-0	2019	Curcumin promotes burn wound healing in mice by upregulating caveolin-1 in epidermal stem cells.	Curcumin	0-8	caveolin 1, caveolae protein	Mus musculus	61-71
17671742-3	2007	Exposure of the synovial fibroblasts to curcumin resulted in growth inhibition and the induction of apoptosis, as measured by MTT assay, fluorescent microscopy and Annexin-V-based assay.	Curcumin	40-48	annexin A5	Homo sapiens	164-173
17671742-5	2007	Curcumin-induced apoptosis was also associated with the proteolytic activation of caspase-3 and caspase-9, and the concomitant degradation of poly(ADP-ribose) polymerase protein.	Curcumin	0-8	caspase 9	Homo sapiens	96-105
17603281-7	2007	In human aortic smooth muscle cells (HASMCs), curcumin also inhibited growth triggered by TNF-alpha and increased p21(WAF1/CIP1) expression via HO-1-dependent manner.	Curcumin	46-54	heme oxygenase 1	Homo sapiens	144-148
17433521-4	2007	Curcumin inhibited CYP1A2 (IC(50), 40.0 microM), CYP3A4 (IC(50), 16.3 microM), CYP2D6 (IC(50), 50.3 microM), CYP2C9 (IC(50), 4.3 microM) and CYP2B6 (IC(50), 24.5 microM).	Curcumin	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	19-25
17433521-4	2007	Curcumin inhibited CYP1A2 (IC(50), 40.0 microM), CYP3A4 (IC(50), 16.3 microM), CYP2D6 (IC(50), 50.3 microM), CYP2C9 (IC(50), 4.3 microM) and CYP2B6 (IC(50), 24.5 microM).	Curcumin	0-8	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	109-115
18778797-6	2008	Using the same methods we found that curcumin, one of the most potent destabilizing agents of Abeta(42), induced dissociation of fibrils of other amyloid polypeptides [Abeta(40), Abeta(42)Nle35, islet amyloid polypeptide and a fragment of alpha-synuclein].	Curcumin	37-45	synuclein alpha	Homo sapiens	239-254
17433521-5	2007	Curcumin showed a competitive type of inhibition towards CYP1A2, CYP3A4 and CYP2B6, whereas a non-competitive type of inhibition was observed with respect to CYP2D6 and CYP2C9.	Curcumin	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	57-63
30461085-7	2019	We also found curcumin treatment elevated caveolin-1 expression in ESCs, which was required for the beneficial effect of curcumin on ESC proliferation and HUVEC tube formation.	Curcumin	14-22	caveolin 1, caveolae protein	Mus musculus	42-52
17383825-5	2007	Indicators of necrosis (alanine aminotransferase) and cholestasis (gamma-glutamyl transpeptidase and bilirubins) resulted in significant increases after CCl4 intoxication, but these effects were prevented by curcumin treatment.	Curcumin	208-216	gamma-glutamyltransferase 1	Rattus norvegicus	67-96
18676361-0	2008	Curcumin blocks the activation of androgen and interlukin-6 on prostate-specific antigen expression in human prostatic carcinoma cells.	Curcumin	0-8	kallikrein related peptidase 3	Homo sapiens	63-88
18676361-2	2008	We evaluated the effects and mechanisms of curcumin on the gene expression of prostate-specific antigen (PSA) in human androgen-sensitive prostatic carcinoma cells.	Curcumin	43-51	kallikrein related peptidase 3	Homo sapiens	78-109
18676361-3	2008	LNCaP cells were used to determine the effect of curcumin on PSA expression.	Curcumin	49-57	kallikrein related peptidase 3	Homo sapiens	61-64
30461085-7	2019	We also found curcumin treatment elevated caveolin-1 expression in ESCs, which was required for the beneficial effect of curcumin on ESC proliferation and HUVEC tube formation.	Curcumin	121-129	caveolin 1, caveolae protein	Mus musculus	42-52
18676361-7	2008	Immunoblot assays, RT-PCR, and ELISA indicated that curcumin treatments blocked the stimulation of methyltrienolone (R1881) and IL-6 on PSA gene expression in LNCaP cells.	Curcumin	52-60	kallikrein related peptidase 3	Homo sapiens	136-139
30461085-8	2019	Next, using a mouse model of burn wound healing, curcumin-treated ESCs exhibited enhanced wound closure, which also required caveolin-1 expression.	Curcumin	49-57	caveolin 1, caveolae protein	Mus musculus	125-135
18676361-8	2008	The effects of curcumin appear to be mediated via the androgen response element of PSA gene.	Curcumin	15-23	kallikrein related peptidase 3	Homo sapiens	83-86
18676361-9	2008	Results from immunoblot assay and EMSA revealed the modulation of curcumin on the expression of androgen receptor and androgen receptor binding activity on androgen response element of PSA gene.	Curcumin	66-74	kallikrein related peptidase 3	Homo sapiens	185-188
30461085-9	2019	Our current study demonstrates the beneficial effect of curcumin on burn wound healing in mice, which is mediated by upregulating caveolin-1 in ESCs, and supports the potential therapeutic role of curcumin in ESC-based treatment against skin wound healing.	Curcumin	56-64	caveolin 1, caveolae protein	Mus musculus	130-140
18676361-11	2008	Curcumin inhibits R1881- and IL-6-mediated PSA gene expression in LNCaP cells through down-regulation of the expression and activity of androgen receptors.	Curcumin	0-8	kallikrein related peptidase 3	Homo sapiens	43-46
17641858-7	2007	At the concentration of 20-80 micromol/L, curcumin, in a dose-dependent manner (P&lt;0.05), could inhibit the expression of PCNA in HPF.	Curcumin	42-50	proliferating cell nuclear antigen	Homo sapiens	124-128
17372590-7	2007	Curcumin interrupts PDGF and EGF signaling demonstrated by inhibiting tyrosine phosphorylation of PDGF-betaR and EGFR and by reducing the levels of phosphorylated phosphatidylinositol-3 kinase (PI-3K/AKT), extracellular signal-regulated kinase (ERK) and the Jun N-terminal kinase (JNK).	Curcumin	0-8	epidermal growth factor	Rattus norvegicus	29-32
19198150-12	2008	Curcumin treatment may have a potential therapeutic role in CMT with PMP22 point mutation in humans.	Curcumin	0-8	peripheral myelin protein 22	Homo sapiens	69-74
30668408-3	2019	PURPOSE: Curcumin has been reported to enhance antitumor properties through the suppression of TP and ERCC1 in non-small cell lung carcinoma cells (NSCLC).	Curcumin	9-17	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	102-107
19260281-7	2008	Curcumine can induce some cells to apoptosis which may be relevant to downregulation of bcl-2 expression and upregulation of P53 expression as well as exhaustion of GSH in tumor organization.	Curcumin	0-9	transformation related protein 53, pseudogene	Mus musculus	125-128
17372590-7	2007	Curcumin interrupts PDGF and EGF signaling demonstrated by inhibiting tyrosine phosphorylation of PDGF-betaR and EGFR and by reducing the levels of phosphorylated phosphatidylinositol-3 kinase (PI-3K/AKT), extracellular signal-regulated kinase (ERK) and the Jun N-terminal kinase (JNK).	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	258-279
17372590-7	2007	Curcumin interrupts PDGF and EGF signaling demonstrated by inhibiting tyrosine phosphorylation of PDGF-betaR and EGFR and by reducing the levels of phosphorylated phosphatidylinositol-3 kinase (PI-3K/AKT), extracellular signal-regulated kinase (ERK) and the Jun N-terminal kinase (JNK).	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	281-284
17372590-9	2007	Our results collectively demonstrate that the interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in activated HSC.	Curcumin	101-109	epidermal growth factor	Rattus norvegicus	75-78
17464175-1	2007	Curcumin is a polyphenolic compound possessing interesting anti-inflammatory and antioxidant properties and has the ability to induce the defensive protein heme oxygenase-1 (HO-1).	Curcumin	0-8	heme oxygenase 1	Homo sapiens	156-172
17464175-1	2007	Curcumin is a polyphenolic compound possessing interesting anti-inflammatory and antioxidant properties and has the ability to induce the defensive protein heme oxygenase-1 (HO-1).	Curcumin	0-8	heme oxygenase 1	Homo sapiens	174-178
17464175-5	2007	In additional experiments, an inhibitor of heme oxygenase activity (tin protoporphyrin IX, 10 microM) or siRNA for HO-1 were used to investigate the participation of HO-1 as a mediator of curcumin-induced effects.	Curcumin	188-196	heme oxygenase 1	Homo sapiens	166-170
31417983-13	2018	It was similar to KitL expression of bovine COCs cultured with curcumin (2.67 +- 1.23), which increased compared to those without curcumin (0.33 +- 0.49) (p &lt;= 0.001).	Curcumin	63-71	KIT ligand	Bos taurus	18-22
17464175-6	2007	Treatment with curcumin produced a marked induction of cardiac HO-1 in normothermic condition but cells were less responsive to the polyphenolic compound at low temperature.	Curcumin	15-23	heme oxygenase 1	Homo sapiens	63-67
17464175-8	2007	Thus, curcumin added to Celsior preservation solution effectively prevents the damage caused by cold-storage; this effect involves the protective enzyme HO-1 but also other not yet identified mechanisms.	Curcumin	6-14	heme oxygenase 1	Homo sapiens	153-157
31417983-14	2018	A significant difference in TNF alpha expression was noted between groups with or without curcumin (p &lt;= 0.001).	Curcumin	90-98	tumor necrosis factor	Bos taurus	28-37
17650800-0	2007	[Effect of curcumin on activity of matrix metalloproteinase 2, 9 and nuclear expression of RelA in rat hepatic stellate cells by activating peroxisome proliferator-activated receptor gamma signal].	Curcumin	11-19	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	91-95
17650800-4	2007	RESULTS: The PPARgamma expression decreased gradually with increasing of HSC activation, which was up-regulated by curcumin (P &lt; 0.01); curcumin inhibited the expression of aSMA, the production of collagen type I, and the nuclear expression of activated RelA (P &lt; 0.01), and elevated the activity of MMP2 and MMP9 significantly (P &lt; 0.01).	Curcumin	139-147	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	257-261
19151449-18	2008	CONCLUSION: the administration of low-dose curcumin showed a trend of reduction in total cholesterol level and LDL cholesterol level in ACS patients.	Curcumin	43-51	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	136-139
29644962-10	2019	Additionally, curcumin increased jejunal mucosa occludin and tight junction protein 1 mRNA and protein levels, and decreased those of rho-associated protein kinase 1 (P&amp;lt;0.05).	Curcumin	14-22	rho-associated protein kinase 1	Anas platyrhynchos	134-165
17461496-1	2007	AIM: To investigate the hypothesis that the protective effects of curcumin in hepatic warm ischemia/reperfusion (I/R) injury are associated with increasing heat shock protein 70 (Hsp70) expression and antioxidant enzyme activity.	Curcumin	66-74	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	156-177
17461496-1	2007	AIM: To investigate the hypothesis that the protective effects of curcumin in hepatic warm ischemia/reperfusion (I/R) injury are associated with increasing heat shock protein 70 (Hsp70) expression and antioxidant enzyme activity.	Curcumin	66-74	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	179-184
17131360-0	2007	Curcumin prevents lipopolysaccharide-induced atrogin-1/MAFbx upregulation and muscle mass loss.	Curcumin	0-8	F-box protein 32	Mus musculus	45-54
30621501-14	2019	The levels of hypoxia-inducible factor-1alpha (HIF-1alpha) and survivin were suppressed by curcumin liposome both in hypoxic cells and liver tissues in the VX2 rabbits.	Curcumin	91-99	hypoxia-inducible factor 1-alpha	Oryctolagus cuniculus	14-45
17131360-0	2007	Curcumin prevents lipopolysaccharide-induced atrogin-1/MAFbx upregulation and muscle mass loss.	Curcumin	0-8	F-box protein 32	Mus musculus	55-60
17131360-11	2007	These results indicate that curcumin is effective in blocking LPS-induced loss of muscle mass through the inhibition of p38-mediated upregulation of atrogin-1/MAFbx.	Curcumin	28-36	F-box protein 32	Mus musculus	149-158
17131360-11	2007	These results indicate that curcumin is effective in blocking LPS-induced loss of muscle mass through the inhibition of p38-mediated upregulation of atrogin-1/MAFbx.	Curcumin	28-36	F-box protein 32	Mus musculus	159-164
17046132-0	2007	The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin.	Curcumin	109-117	glutathione S-transferase kappa 1	Homo sapiens	24-50
17046132-4	2007	Using 1-chloro-2,4 dinitrobenzene (CDNB) as a substrate, ellagic acid and curcumin were shown to inhibit GSTs A1-1, A2-2, M1-1, M2-2 and P1-1 with IC(50) values ranging from 0.04 to 5 microM whilst genistein, kaempferol and quercetin inhibited GSTs M1-1 and M2-2 only.	Curcumin	74-82	glutathione S-transferase kappa 1	Homo sapiens	105-109
19016748-5	2008	Under the stress induced by serum depletion or curcumin treatment, OPN expression promoted the survival of ovarian cells through preventing stress-induced apoptosis.	Curcumin	47-55	secreted phosphoprotein 1	Homo sapiens	67-70
30621501-14	2019	The levels of hypoxia-inducible factor-1alpha (HIF-1alpha) and survivin were suppressed by curcumin liposome both in hypoxic cells and liver tissues in the VX2 rabbits.	Curcumin	91-99	hypoxia-inducible factor 1-alpha	Oryctolagus cuniculus	47-57
16713233-3	2007	Curcumin treatment caused an up to sevenfold, concentration-dependent increase in LDL-receptor mRNA, whereas mRNAs of the genes encoding the sterol biosynthetic enzymes HMG CoA reductase and farnesyl diphosphate synthase were only slightly increased at high curcumin concentrations where cell viability was reduced.	Curcumin	0-8	low density lipoprotein receptor	Homo sapiens	82-94
30621501-16	2019	Curcumin liposome suppressed the HIF-1alpha and survivin levels and inhibited the angiogenesis in VX2 rabbits after TAE.	Curcumin	0-8	hypoxia-inducible factor 1-alpha	Oryctolagus cuniculus	33-43
17569214-1	2007	Curcumin possesses anti-inflammatory activity and is a potent inhibitor of reactive-oxygen-generating enzymes such as lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase, and inducible nitric oxide synthase (iNOS); it is an effective inducer of heme oxygenase-1.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	253-269
30001951-0	2019	Both glypican-3/Wnt/beta-catenin signaling pathway and autophagy contributed to the inhibitory effect of curcumin on hepatocellular carcinoma.	Curcumin	105-113	glypican 3	Homo sapiens	5-15
17569214-3	2007	Subsequently, curcumin inhibits the activation of NF-KB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs, and iNOS.	Curcumin	14-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	113-118
17569214-3	2007	Subsequently, curcumin inhibits the activation of NF-KB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs, and iNOS.	Curcumin	14-22	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	120-123
17569214-3	2007	Subsequently, curcumin inhibits the activation of NF-KB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs, and iNOS.	Curcumin	14-22	EPH receptor B2	Homo sapiens	132-135
17310109-6	2007	Exposure of erythrocytes to Curcumin (= 1 microM) increased annexin V binding and decreased forward scatter, pointing to phosphatidylserine exposure at the cell surface and cell shrinkage.	Curcumin	28-36	annexin A5	Homo sapiens	60-69
17290611-1	2006	AIM: To study the effect of curcumin on the apoptosis of prostate cancer cell line LNCaP and regulation of expression of maspin gene.	Curcumin	28-36	serpin family B member 5	Homo sapiens	121-127
30001951-0	2019	Both glypican-3/Wnt/beta-catenin signaling pathway and autophagy contributed to the inhibitory effect of curcumin on hepatocellular carcinoma.	Curcumin	105-113	catenin beta 1	Homo sapiens	20-32
17290611-5	2006	Through detecting the activity of luciferase, the effect of curcumin on the promoter of maspin was studied.	Curcumin	60-68	serpin family B member 5	Homo sapiens	88-94
30001951-1	2019	AIM: The aim of this study is to investigate the role of glypican-3(GPC3)/wnt/beta-catenin signaling pathway and autophagy in the regulation of hepatocellular carcinoma (HCC) growth mediated by curcumin.	Curcumin	194-202	glypican 3	Homo sapiens	57-67
17290611-6	2006	RESULTS: Curcumin inhibited cell growth, induced the apoptosis and enhanced the expression of maspin gene in LNCaP cells.	Curcumin	9-17	serpin family B member 5	Homo sapiens	94-100
17290611-7	2006	CONCLUSION: Curcumin up-regulated expression of maspin gene in LNCaP cells through enhancing the transcription activity of promoter of maspin gene.	Curcumin	12-20	serpin family B member 5	Homo sapiens	48-54
30001951-1	2019	AIM: The aim of this study is to investigate the role of glypican-3(GPC3)/wnt/beta-catenin signaling pathway and autophagy in the regulation of hepatocellular carcinoma (HCC) growth mediated by curcumin.	Curcumin	194-202	glypican 3	Homo sapiens	68-72
17290611-7	2006	CONCLUSION: Curcumin up-regulated expression of maspin gene in LNCaP cells through enhancing the transcription activity of promoter of maspin gene.	Curcumin	12-20	serpin family B member 5	Homo sapiens	135-141
30001951-1	2019	AIM: The aim of this study is to investigate the role of glypican-3(GPC3)/wnt/beta-catenin signaling pathway and autophagy in the regulation of hepatocellular carcinoma (HCC) growth mediated by curcumin.	Curcumin	194-202	catenin beta 1	Homo sapiens	78-90
17201158-6	2006	Curcumin also promoted the expression of Bax, cytochrome C, p53 and p21 but inhibited the expression of Bcl-2.	Curcumin	0-8	H3 histone pseudogene 16	Homo sapiens	68-71
30001951-7	2019	Further analysis showed that curcumin treatment inactivated Wnt/beta-catenin signaling and decreased GPC3 expression, silencing of GPC3 expression promoted the effects of curcumin on Wnt/beta-catenin signaling.	Curcumin	29-37	catenin beta 1	Homo sapiens	64-76
30001951-7	2019	Further analysis showed that curcumin treatment inactivated Wnt/beta-catenin signaling and decreased GPC3 expression, silencing of GPC3 expression promoted the effects of curcumin on Wnt/beta-catenin signaling.	Curcumin	29-37	glypican 3	Homo sapiens	101-105
30001951-7	2019	Further analysis showed that curcumin treatment inactivated Wnt/beta-catenin signaling and decreased GPC3 expression, silencing of GPC3 expression promoted the effects of curcumin on Wnt/beta-catenin signaling.	Curcumin	171-179	glypican 3	Homo sapiens	131-135
30001951-7	2019	Further analysis showed that curcumin treatment inactivated Wnt/beta-catenin signaling and decreased GPC3 expression, silencing of GPC3 expression promoted the effects of curcumin on Wnt/beta-catenin signaling.	Curcumin	171-179	catenin beta 1	Homo sapiens	187-199
16880289-0	2006	Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition.	Curcumin	0-8	aryl hydrocarbon receptor nuclear translocator	Mus musculus	58-104
30001951-8	2019	In addition, inhibiting autophagy by 3-MA relieved curcumin-dependent down-regulation of GPC3.	Curcumin	51-59	glypican 3	Homo sapiens	89-93
16880289-7	2006	Moreover, of the two HIF-1 subunits, only ARNT was found to be destabilized by curcumin in several cancer cell types, and furthermore, ARNT expression rescued HIF-1 repression by curcumin.	Curcumin	79-87	aryl hydrocarbon receptor nuclear translocator	Mus musculus	42-46
30001951-9	2019	CONCLUSION: Curcumin suppressed HCC tumor growth through down-regulating GPC3/wnt/beta-catenin signaling pathway, which was partially mediated by activation of autophagy.	Curcumin	12-20	glypican 3	Homo sapiens	73-77
16880289-7	2006	Moreover, of the two HIF-1 subunits, only ARNT was found to be destabilized by curcumin in several cancer cell types, and furthermore, ARNT expression rescued HIF-1 repression by curcumin.	Curcumin	179-187	aryl hydrocarbon receptor nuclear translocator	Mus musculus	135-139
16880289-8	2006	We also found that curcumin stimulated the proteasomal degradation of ARNT via oxidation and ubiquitination processes.	Curcumin	19-27	aryl hydrocarbon receptor nuclear translocator	Mus musculus	70-74
30001951-9	2019	CONCLUSION: Curcumin suppressed HCC tumor growth through down-regulating GPC3/wnt/beta-catenin signaling pathway, which was partially mediated by activation of autophagy.	Curcumin	12-20	catenin beta 1	Homo sapiens	82-94
16880289-9	2006	In mice bearing Hep3B hepatoma, curcumin retarded tumor growth and suppressed ARNT, erythropoietin, and vascular endothelial growth factor in tumors.	Curcumin	32-40	aryl hydrocarbon receptor nuclear translocator	Mus musculus	78-82
31640096-4	2019	Recently, we reported the development of curcumin analogs and identified a lead compound, curcumin-like compound-R17 (CLC-R17), that significantly attenuates Abeta deposition in an AD transgenic mouse model.	Curcumin	90-98	amyloid beta (A4) precursor protein	Mus musculus	158-163
16880289-9	2006	In mice bearing Hep3B hepatoma, curcumin retarded tumor growth and suppressed ARNT, erythropoietin, and vascular endothelial growth factor in tumors.	Curcumin	32-40	erythropoietin	Mus musculus	84-98
16880289-10	2006	These results suggest that the anticancer activity of curcumin is attributable to HIF-1 inactivation by ARNT degradation.	Curcumin	54-62	aryl hydrocarbon receptor nuclear translocator	Mus musculus	104-108
16934299-7	2006	By analysis of inhibitory features of specific MAPK inhibitors, a series of signaling cascades including c-Jun N-terminal kinase (JNK), p38 and NF-kappaB was found to play a critical role in curcumin-mediated NO inhibition in microglial cells.	Curcumin	191-199	mitogen-activated protein kinase 8	Rattus norvegicus	105-128
16934299-7	2006	By analysis of inhibitory features of specific MAPK inhibitors, a series of signaling cascades including c-Jun N-terminal kinase (JNK), p38 and NF-kappaB was found to play a critical role in curcumin-mediated NO inhibition in microglial cells.	Curcumin	191-199	mitogen-activated protein kinase 8	Rattus norvegicus	130-133
16805852-1	2006	To elucidate the mechanism underlying suppression by curcumin of esophageal carcinogenesis induced by NMBA, we evaluated the CYP level and mutagenic activation of environmental carcinogens, by immunoblot analyses and Ames preincubation test, respectively, and bilirubin, 4-nitrophenol and testosterone UDPGT activities in F344 rats treated with curcumin and/or NMBA.	Curcumin	53-61	UDP glucuronosyltransferase family 2 member B15	Rattus norvegicus	302-307
16953118-1	2006	Recently, it has been reported that curcumin, which is known as a potent antioxidant, acts as a non- stressful and non-cytotoxic inducer of the cytoprotective heme oxygenase (HO)-1.	Curcumin	36-44	heme oxygenase 1	Homo sapiens	159-180
16723087-0	2006	Down-regulation of p210(bcr/abl) by curcumin involves disrupting molecular chaperone functions of Hsp90.	Curcumin	36-44	heat shock protein 90 alpha family class A member 1	Homo sapiens	98-103
16516148-0	2006	Curcumin enhances the polyglutamine-expanded truncated N-terminal huntingtin-induced cell death by promoting proteasomal malfunction.	Curcumin	0-8	huntingtin	Mus musculus	66-76
16516148-4	2006	Here, we found that the treatment of curcumin increases the polyglutamine-expanded truncated N-terminal huntingtin (mutant huntingtin) aggregation and mutant huntingtin-dependent cell death.	Curcumin	37-45	huntingtin	Mus musculus	104-114
16516148-4	2006	Here, we found that the treatment of curcumin increases the polyglutamine-expanded truncated N-terminal huntingtin (mutant huntingtin) aggregation and mutant huntingtin-dependent cell death.	Curcumin	37-45	huntingtin	Mus musculus	123-133
16516148-4	2006	Here, we found that the treatment of curcumin increases the polyglutamine-expanded truncated N-terminal huntingtin (mutant huntingtin) aggregation and mutant huntingtin-dependent cell death.	Curcumin	37-45	huntingtin	Mus musculus	123-133
16516148-5	2006	Curcumin also causes rapid proteasomal malfunction in the mutant huntingtin expressing cells in comparison with normal glutamine repeat expressing cells.	Curcumin	0-8	huntingtin	Mus musculus	65-75
16516148-6	2006	Finally, we show that N-acetyl cysteine (NAC), a potent antioxidant, reverted the curcumin-induced mutant huntingtin aggregation and proteasomal malfunction in the mutant huntingtin expressing cells.	Curcumin	82-90	huntingtin	Mus musculus	106-116
16516148-6	2006	Finally, we show that N-acetyl cysteine (NAC), a potent antioxidant, reverted the curcumin-induced mutant huntingtin aggregation and proteasomal malfunction in the mutant huntingtin expressing cells.	Curcumin	82-90	huntingtin	Mus musculus	171-181
16516148-8	2006	Our result suggests that curcumin promotes mutant huntingtin-induced cell death by mimicking proteasomal dysfunction.	Curcumin	25-33	huntingtin	Mus musculus	50-60
16445949-12	2006	Using TRAP assay it has been observed that curcumin inhibits telomerase activity in a dose and time-dependent manner, the inhibition being due to suppression of translocation of telomerase reverse transcriptase (TERT), a catalytic subunit, from cytosol to nucleus.	Curcumin	43-51	telomerase reverse transcriptase	Homo sapiens	178-210
16445949-12	2006	Using TRAP assay it has been observed that curcumin inhibits telomerase activity in a dose and time-dependent manner, the inhibition being due to suppression of translocation of telomerase reverse transcriptase (TERT), a catalytic subunit, from cytosol to nucleus.	Curcumin	43-51	telomerase reverse transcriptase	Homo sapiens	212-216
16294327-8	2006	Curcumin inhibited platelet-derived growth factor (PDGF)-induced proliferation, alpha-smooth muscle actin gene expression, interleukin-1beta- and tumor necrosis factor (TNF)-alpha-induced MCP-1 production, type I collagen production, and expression of type I and type III collagen genes.	Curcumin	0-8	actin gamma 2, smooth muscle	Rattus norvegicus	80-105
16460683-4	2006	Curcumin increased HO-1 and glutamyl cysteine ligase modulator (GCLM) expression and stimulated Nrf2 binding to the ARE.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	19-23
16460683-5	2006	Curcumin also rapidly stimulated PKC phosphorylation and Ro-31-8220, a pan-PKC inhibitor, decreased curcumin-induced GCLM and HO-1 mRNA expression and ARE binding.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	126-130
16460683-5	2006	Curcumin also rapidly stimulated PKC phosphorylation and Ro-31-8220, a pan-PKC inhibitor, decreased curcumin-induced GCLM and HO-1 mRNA expression and ARE binding.	Curcumin	100-108	heme oxygenase 1	Homo sapiens	126-130
16460683-6	2006	Rottlerin (a PKC delta inhibitor) and PKC delta antisense oligonucleotides significantly inhibited curcumin-induced GCLM and HO-1 mRNA expression and ARE binding.	Curcumin	99-107	heme oxygenase 1	Homo sapiens	125-129
16702625-4	2006	Intragastric administration of BDMCA or curcumin to DMH-treated rats significantly decreased colon tumor incidence and the circulatory LPO, with simultaneous enhancement of GSH content and GPx, GST, SOD and CAT activities.	Curcumin	40-48	hematopoietic prostaglandin D synthase	Rattus norvegicus	194-197
16495813-4	2006	This study investigates in detail the effect of curcumin on the stress-response in human hepatocytes, in particular its effect on heme oxygenase 1 (HO-1) and its cytoprotective effect.	Curcumin	48-56	heme oxygenase 1	Homo sapiens	130-146
16495813-4	2006	This study investigates in detail the effect of curcumin on the stress-response in human hepatocytes, in particular its effect on heme oxygenase 1 (HO-1) and its cytoprotective effect.	Curcumin	48-56	heme oxygenase 1	Homo sapiens	148-152
16361152-0	2005	[Apoptosis induced by curcumin and its effect on c-myc and caspase-3 expressions in human melanoma A375 cell line].	Curcumin	22-30	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	49-54
16361152-1	2005	OBJECTIVE: To investigate the effect of curcumin on cell apoptosis and c-myc and caspase-3 expressions in human melanoma A375 cell line.	Curcumin	40-48	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	71-76
16361152-8	2005	c-myc expression level was decreased whereas caspase-3 expression increased with the increase in curcumin concentrations.	Curcumin	97-105	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
16198311-3	2005	RNase protection assay showed that curcumin inhibited the PMA-induced mRNA expression of MMP-1, -3, -9, and -14.	Curcumin	35-43	matrix metallopeptidase 1	Homo sapiens	89-111
16198311-4	2005	Curcumin repressed the DNA binding and transcriptional activities of AP-1, which is a common upstream modulator of MMP-1, -3, and -9 gene expression.	Curcumin	0-8	matrix metallopeptidase 1	Homo sapiens	115-132
16198311-5	2005	In addition, curcumin suppressed the PMA-induced MAP kinase activities, which were differentially involved in modulating the MMPs.	Curcumin	13-21	matrix metallopeptidase 1	Homo sapiens	125-129
16358608-10	2005	Curcumin (AP-1 inhibitor) markedly suppressed the TNF-alpha-induced CCL2 expression.	Curcumin	0-8	C-C motif chemokine ligand 2	Homo sapiens	68-72
16153607-2	2005	We reported previously that curcumin (Cur) inhibits fAbeta formation from Abeta and destabilizes preformed fAbeta in vitro.	Curcumin	28-36	FA complementation group B	Homo sapiens	52-58
16153607-2	2005	We reported previously that curcumin (Cur) inhibits fAbeta formation from Abeta and destabilizes preformed fAbeta in vitro.	Curcumin	28-36	FA complementation group B	Homo sapiens	107-113
16083495-1	2005	BACKGROUND: Inhibition of the COP9 signalosome (CSN) associated kinases CK2 and PKD by curcumin causes stabilization of the tumor suppressor p53.	Curcumin	87-95	COP9 signalosome subunit 8	Homo sapiens	30-34
15870875-0	2005	Curcumin decreases cell proliferation rates through BTG2-mediated cyclin D1 down-regulation in U937 cells.	Curcumin	0-8	BTG anti-proliferation factor 2	Homo sapiens	52-56
15870875-8	2005	Treatment of curcumin increased expression of BTG2 mRNA, a member of anti-proliferative gene family and a negative transcriptional regulator of cyclin D1.	Curcumin	13-21	BTG anti-proliferation factor 2	Homo sapiens	46-50
15870875-13	2005	The data presented here indicate that curcumin-induced down-regulation of cyclin D1 mRNA is mediated by induction of BTG2 as well as inhibition of nuclear translocation of NF-kappaB.	Curcumin	38-46	BTG anti-proliferation factor 2	Homo sapiens	117-121
15842781-7	2005	The expression levels of HDAC1, HDAC3, and HDAC8 proteins were downregulated following curcumin treatment in Raji cells, whereas Ac-histone H4 protein expression was upregulated after treatment with curcumin.	Curcumin	87-95	histone deacetylase 8	Homo sapiens	43-48
15842781-8	2005	CONCLUSION: Curcumin, as a new member of the histone deacetylase inhibitors, can inhibit the expression of class I HDACs (HDAC1, HDAC3, and HDAC8), and can increase the expression of Ac-histone H4 in Raji cells.	Curcumin	12-20	histone deacetylase 8	Homo sapiens	140-145
15957838-3	2005	And the expression of LDL-R gene in XLO was quantitatively determined by ELISA after being interfered with different concentrations of curcumin.	Curcumin	135-143	low density lipoprotein receptor	Homo sapiens	22-27
15957838-4	2005	RESULTS: The human LDL-R gene could be expressed on XLO, which could be significantly enhanced by curcumin in a dose-dependent manner.	Curcumin	98-106	low density lipoprotein receptor	Homo sapiens	19-24
15957838-5	2005	Conclusion One of the paths of curcumin in reducing blood lipids and anti-atherosclerosis was improving LDL-R gene expression and increasing the LDL-cholesterol absorption of cells.	Curcumin	31-39	low density lipoprotein receptor	Homo sapiens	104-109
15746179-7	2005	In contrast, atrogin1/MAFbx up-regulation and the associated increase in ubiquitin conjugating activity were both blunted by p38 inhibitors, either SB203580 or curcumin.	Curcumin	160-168	F-box protein 32	Mus musculus	13-21
15746179-7	2005	In contrast, atrogin1/MAFbx up-regulation and the associated increase in ubiquitin conjugating activity were both blunted by p38 inhibitors, either SB203580 or curcumin.	Curcumin	160-168	F-box protein 32	Mus musculus	22-27
15713895-11	2005	Considering its role in apoptosis, we determined the contribution of ATF3 to the antitumor effect of curcumin.	Curcumin	101-109	activating transcription factor 3	Homo sapiens	69-73
15713895-12	2005	Curcumin-treated MDA-1986 cells showed a rapid, dose-dependent increase in ATF3/mRNA protein.	Curcumin	0-8	activating transcription factor 3	Homo sapiens	75-79
15713895-13	2005	Moreover, expression of an exogenous ATF3 cDNA synergized with curcumin in inducing apoptosis.	Curcumin	63-71	activating transcription factor 3	Homo sapiens	37-41
15713895-14	2005	Thus, we have identified several putative, novel molecular targets of curcumin and showed that one, (ATF3) contributes to the proapoptotic effects of this compound.	Curcumin	70-78	activating transcription factor 3	Homo sapiens	101-105
16471035-7	2005	Combined curcumin and TRAIL treatment produced the most loss of viable cells by inducing apoptosis as revealed by accumulation of hypodiploid cells in sub-G1 phase, enhanced annexin V binding, DNA fragmentation, cleavage of procaspases-3, -8, and 9, truncation of proapoptotic Bid, and release of cytochrome c from mitochondria.	Curcumin	9-17	annexin A5	Homo sapiens	174-183
15491342-9	2004	Exposure to genistein and curcumin inhibited EGF-stimulated urokinase production, although only genistein showed a statistically significant inhibitory response.	Curcumin	26-34	epidermal growth factor	Homo sapiens	45-48
15491342-13	2004	Finally, EGF stimulated the phosphorylation of its receptor and tyrphostin (AG1478), curcumin and genistein were able to inhibit this stimulatory effect.	Curcumin	85-93	epidermal growth factor	Homo sapiens	9-12
15491342-15	2004	Our data also shows that EGF-stimulated uPA production involves the activation of the extracellular signal-regulated kinases 1/2 and JNK signaling pathways and might be modulated by the natural phytoestrogens curcumin and genistein.	Curcumin	209-217	epidermal growth factor	Homo sapiens	25-28
15480428-6	2004	The RTKN-mediated antiapoptotic effect was blocked by the nuclear factor-kappaB (NF-kappaB) inhibitors, curcumin or parthenolide, but not by the phosphatidylinositol 3"-OH-kinase inhibitor, LY294002, or the MAP kinase inhibitor, PD98059.	Curcumin	104-112	rhotekin	Homo sapiens	4-8
15203111-3	2004	Curcumin pre and post-treatment (PPT) was shown to decrease the levels of xanthine oxidase, superoxide anion, lipid peroxides (LPs) and myeloperoxidase while the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) activities were significantly increased after curcumin PPT.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Rattus norvegicus	246-271
15203111-3	2004	Curcumin pre and post-treatment (PPT) was shown to decrease the levels of xanthine oxidase, superoxide anion, lipid peroxides (LPs) and myeloperoxidase while the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) activities were significantly increased after curcumin PPT.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Rattus norvegicus	273-276
18987596-7	2008	In small intestine, beta-naphthoflavone, diallyl sulphide and curcumin induced CYP1A1 and CYP2B1.	Curcumin	62-70	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	79-85
18299980-5	2008	The identification of several new cell cycle control genes, including the apoptosis-related protein (pirin) and insulin-like growth factor (IGF), and of the neurofilament M protein involved in neurogenesis suggests that curcumin may have applicability in the treatment of a spectrum of neurodegenerative diseases.	Curcumin	220-228	insulin-like growth factor 1	Rattus norvegicus	112-138
18299980-5	2008	The identification of several new cell cycle control genes, including the apoptosis-related protein (pirin) and insulin-like growth factor (IGF), and of the neurofilament M protein involved in neurogenesis suggests that curcumin may have applicability in the treatment of a spectrum of neurodegenerative diseases.	Curcumin	220-228	insulin-like growth factor 1	Rattus norvegicus	140-143
18685195-0	2008	Inhibition of thioredoxin reductase by curcumin analogs.	Curcumin	39-47	peroxiredoxin 5	Homo sapiens	14-35
18685195-1	2008	Curcumin analogs were first investigated for their inhibitory effects on thioredoxin reductase (TrxR).	Curcumin	0-8	peroxiredoxin 5	Homo sapiens	73-94
15356994-3	2004	Curcumin possesses anti-inflammatory activity and is a potent inhibitor of reactive oxygen-generating enzymes such as lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase and inducible nitric oxide synthase; and an effective inducer of heme oxygenase-1.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	243-259
31640096-9	2019	Collectively, our data reveal mechanisms of a promising curcumin analog in reducing Abeta levels, which strongly support its development as a potential therapeutic for AD.	Curcumin	56-64	amyloid beta (A4) precursor protein	Mus musculus	84-89
15356994-4	2004	Curcumin is also a potent inhibitor of protein kinase C (PKC), EGF(Epidermal growth factor)-receptor tyrosine kinase and IkappaB kinase.	Curcumin	0-8	epidermal growth factor	Homo sapiens	63-116
15356994-5	2004	Subsequently, curcumin inhibits the activation of NF(nucleor factor)kappaB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs and iNOS.	Curcumin	14-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	132-137
15356994-5	2004	Subsequently, curcumin inhibits the activation of NF(nucleor factor)kappaB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs and iNOS.	Curcumin	14-22	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	139-142
30276838-6	2019	Reverse transcription-polymerase chain reaction analysis revealed that curcumin reduced the dodecanol-induced overexpression of the ABC transporter-related genes PDR1, PDR3 and PDR5 to their control levels in untreated cells.	Curcumin	71-79	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	162-166
15356994-5	2004	Subsequently, curcumin inhibits the activation of NF(nucleor factor)kappaB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs and iNOS.	Curcumin	14-22	EPH receptor B2	Homo sapiens	151-154
15179184-4	2004	Curcumin induced melanoma cell apoptosis and cell cycle arrest, which is associated with the downregulation of NFkappaB activation, iNOS and DNA-dependent protein kinase catalytic subunit expression, and upregulation of p53, p21(Cip1), p27(Kip1) and checkpoint kinase 2.	Curcumin	0-8	interferon alpha inducible protein 27	Homo sapiens	236-239
15179184-4	2004	Curcumin induced melanoma cell apoptosis and cell cycle arrest, which is associated with the downregulation of NFkappaB activation, iNOS and DNA-dependent protein kinase catalytic subunit expression, and upregulation of p53, p21(Cip1), p27(Kip1) and checkpoint kinase 2.	Curcumin	0-8	cyclin dependent kinase inhibitor 1B	Homo sapiens	240-244
15128775-7	2004	RANKL induced osteoclastogenesis in these monocytic cells, and curcumin inhibited both RANKL- and TNF-induced osteoclastogenesis and pit formation.	Curcumin	63-71	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	87-92
15128775-8	2004	Curcumin suppressed osteoclastogenesis maximally when added together with RANKL and minimally when it was added 2 days after RANKL.	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	74-79
15128775-8	2004	Curcumin suppressed osteoclastogenesis maximally when added together with RANKL and minimally when it was added 2 days after RANKL.	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	125-130
15128775-9	2004	Whether curcumin inhibits RANKL-induced osteoclastogenesis through suppression of NF-kappaB was also confirmed independently, as RANKL failed to activate NF-kappaB in cells stably transfected with a dominant-negative form of IkappaBalpha and concurrently failed to induce osteoclastogenesis.	Curcumin	8-16	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	26-31
15128775-10	2004	Thus overall these results indicate that RANKL induces osteoclastogenesis through the activation of NF-kappaB, and treatment with curcumin inhibits both the NF-kappaB activation and osteoclastogenesis induced by RANKL.	Curcumin	130-138	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	212-217
30599093-9	2019	Additionally, the cholesterol transmembrane regulators ABCA1, ABCG1, and CAV1 were enhanced by curcumin in vivo.	Curcumin	95-103	ATP binding cassette subfamily G member 1	Mus musculus	62-67
15022320-13	2004	PD 98059, fludarabine, piceatannol, and curcumin (AP-1 inhibitor) inhibited the OSM-induced expression of CCL2.	Curcumin	40-48	C-C motif chemokine ligand 2	Homo sapiens	106-110
30599093-9	2019	Additionally, the cholesterol transmembrane regulators ABCA1, ABCG1, and CAV1 were enhanced by curcumin in vivo.	Curcumin	95-103	caveolin 1, caveolae protein	Mus musculus	73-77
30542713-0	2019	Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways.	Curcumin	0-8	epidermal growth factor	Homo sapiens	41-44
15339049-0	2004	Curcumin, a multi-functional chemopreventive agent, blocks growth of colon cancer cells by targeting beta-catenin-mediated transactivation and cell-cell adhesion pathways.	Curcumin	0-8	catenin beta 1	Homo sapiens	101-113
30542713-5	2019	As high glucose is able to induce the expression of epidermal growth factor (EGF), which is intimately related with tumor progression, the aim of this study was to evaluate whether curcumin could influence the high glucose-induced EGF/EGFR pathway and the biological activity of pancreatic cancer cells.	Curcumin	181-189	epidermal growth factor	Homo sapiens	52-75
30542713-5	2019	As high glucose is able to induce the expression of epidermal growth factor (EGF), which is intimately related with tumor progression, the aim of this study was to evaluate whether curcumin could influence the high glucose-induced EGF/EGFR pathway and the biological activity of pancreatic cancer cells.	Curcumin	181-189	epidermal growth factor	Homo sapiens	77-80
30542713-5	2019	As high glucose is able to induce the expression of epidermal growth factor (EGF), which is intimately related with tumor progression, the aim of this study was to evaluate whether curcumin could influence the high glucose-induced EGF/EGFR pathway and the biological activity of pancreatic cancer cells.	Curcumin	181-189	epidermal growth factor	Homo sapiens	231-234
15182583-6	2004	The A value of the expression level of STAT5 protein in curcumin group was 15 266 +/- 769, significantly less than 25 781 +/- 1240 of that in K562 cell group (P &lt; 0.01).	Curcumin	56-64	signal transducer and activator of transcription 5A	Homo sapiens	39-44
30542713-12	2019	EGF-induced proliferative, invasive and migratory abilities of BxPC-3 cells were abrogated by curcumin, LY 294002 and PD 98059.	Curcumin	94-102	epidermal growth factor	Homo sapiens	0-3
15182583-7	2004	CONCLUSION: The expressions of STAT5 mRNA and protein in K562 cells were inhibited by curcumin and curcumin could inhibit K562 cell proliferation.	Curcumin	86-94	signal transducer and activator of transcription 5A	Homo sapiens	31-36
30542713-13	2019	In addition, EGF-modulated activation of EGFR, ERK and Akt, as well as the expression of uPA and E-cadherin were inhibited by curcumin.	Curcumin	126-134	epidermal growth factor	Homo sapiens	13-16
15182583-7	2004	CONCLUSION: The expressions of STAT5 mRNA and protein in K562 cells were inhibited by curcumin and curcumin could inhibit K562 cell proliferation.	Curcumin	99-107	signal transducer and activator of transcription 5A	Homo sapiens	31-36
30542713-14	2019	Taken together, the present study indicates that curcumin suppresses hyperglycemia-driven EGF-induced invasion and migration of pancreatic cancer cells by inhibiting the EGF/EGFR signaling pathway and its downstream signaling molecules including ERK and Akt.	Curcumin	49-57	epidermal growth factor	Homo sapiens	90-93
30542713-14	2019	Taken together, the present study indicates that curcumin suppresses hyperglycemia-driven EGF-induced invasion and migration of pancreatic cancer cells by inhibiting the EGF/EGFR signaling pathway and its downstream signaling molecules including ERK and Akt.	Curcumin	49-57	epidermal growth factor	Homo sapiens	170-173
30772790-6	2019	Our results showed that both curcumin and donepezil improved memory and inhibited acetylcholinesterase, however curcumin inhibited AchE with more potency than donepezil when compared to vehicle control rats.	Curcumin	29-37	acetylcholinesterase	Rattus norvegicus	82-102
14758033-0	2004	Curcumin ameliorates left ventricular function in rabbits with pressure overload: inhibition of the remodeling of the left ventricular collagen network associated with suppression of myocardial tumor necrosis factor-alpha and matrix metalloproteinase-2 expression.	Curcumin	0-8	tumor necrosis factor	Oryctolagus cuniculus	194-221
14758033-0	2004	Curcumin ameliorates left ventricular function in rabbits with pressure overload: inhibition of the remodeling of the left ventricular collagen network associated with suppression of myocardial tumor necrosis factor-alpha and matrix metalloproteinase-2 expression.	Curcumin	0-8	72 kDa type IV collagenase	Oryctolagus cuniculus	226-252
14758033-8	2004	Myocardial tumor necrosis factor (TNF)-alpha and matrix metalloproteinase (MMP)-2 expression were significantly overexpressed in the vehicle group and markedly suppressed in the curcumin group at both the 4th and 8th weeks.	Curcumin	178-186	tumor necrosis factor	Oryctolagus cuniculus	11-44
14758033-8	2004	Myocardial tumor necrosis factor (TNF)-alpha and matrix metalloproteinase (MMP)-2 expression were significantly overexpressed in the vehicle group and markedly suppressed in the curcumin group at both the 4th and 8th weeks.	Curcumin	178-186	72 kDa type IV collagenase	Oryctolagus cuniculus	49-81
15750784-10	2004	Curcumin, a known anti-inflammatory and anticarcinogenic compound, suppresses OPN-induced cell migration, invasion and induces apoptotic morphology in OPN-treated cells.	Curcumin	0-8	secreted phosphoprotein 1	Homo sapiens	78-81
15750784-10	2004	Curcumin, a known anti-inflammatory and anticarcinogenic compound, suppresses OPN-induced cell migration, invasion and induces apoptotic morphology in OPN-treated cells.	Curcumin	0-8	secreted phosphoprotein 1	Homo sapiens	151-154
15750784-11	2004	The mechanism by which curcumin suppresses the OPN-induced effects has also been delineated.	Curcumin	23-31	secreted phosphoprotein 1	Homo sapiens	47-50
14722241-2	2004	In this study, microarray analysis of gene expression profiles were used to characterize the anti-invasive mechanisms of curcumin in highly invasive lung adenocarcinoma cells (CL1-5).	Curcumin	121-129	adhesion G protein-coupled receptor L1	Homo sapiens	176-179
14722241-3	2004	Results showed that curcumin significantly reduces the invasive capacity of CL1-5 cells in a concentration range far below its levels of cytotoxicity (20 microM) and that this anti-invasive effect was concentration dependent (10.17 +/- 0.76 x 10(3) cells at 0 microM; 5.67 +/- 1.53 x 10(3) cells at 1 microM; 2.67 +/- 0.58 x 10(3) cells at 5 microM; 1.15 +/- 1.03 x 10(3) cells at 10 microM; P &lt; 0.05) in the Transwell cell culture chamber assay.	Curcumin	20-28	adhesion G protein-coupled receptor L1	Homo sapiens	76-79
14680379-10	2003	In conclusion, curcumin clearly inhibits both MRP1- and MRP2-mediated transport, but the glutathione-dependent metabolism of curcumin plays a crucial role in the ultimate level of inhibition of MRP-mediated transport that can be achieved in a cellular system.	Curcumin	15-23	ATP binding cassette subfamily C member 1	Canis lupus familiaris	46-50
14634121-5	2003	Curcumin markedly inhibited the phosphorylation of STAT1 and 3 as well as JAK1 and 2 in microglia activated with gangliosides, LPS, or IFN-gamma.	Curcumin	0-8	interferon gamma	Rattus norvegicus	135-144
18348204-8	2008	Monoallelic IGF2 expression was maintained in curcumin-treated cancer cells, indicating the involvement of mechanism/s other than disturbance of CTCF insulator function at the IGF2/H19 locus.	Curcumin	46-54	H19 imprinted maternally expressed transcript	Homo sapiens	181-184
30772790-6	2019	Our results showed that both curcumin and donepezil improved memory and inhibited acetylcholinesterase, however curcumin inhibited AchE with more potency than donepezil when compared to vehicle control rats.	Curcumin	112-120	acetylcholinesterase	Rattus norvegicus	131-135
14634121-6	2003	Curcumin consistently suppressed not only NF binding to IFN-gamma-activated sequence/IFN-stimulated regulatory element, but also the expression of inflammation-associated genes, including ICAM-1 and monocyte chemoattractant protein 1, whose promoters contain STAT-binding elements.	Curcumin	0-8	interferon gamma	Rattus norvegicus	56-65
14634121-6	2003	Curcumin consistently suppressed not only NF binding to IFN-gamma-activated sequence/IFN-stimulated regulatory element, but also the expression of inflammation-associated genes, including ICAM-1 and monocyte chemoattractant protein 1, whose promoters contain STAT-binding elements.	Curcumin	0-8	C-C motif chemokine ligand 2	Rattus norvegicus	199-233
30599890-0	2019	Curcumin and quercetin synergistically inhibit cancer cell proliferation in multiple cancer cells and modulate Wnt/beta-catenin signaling and apoptotic pathways in A375 cells.	Curcumin	0-8	catenin beta 1	Homo sapiens	115-127
14726605-5	2003	However, experiments with known inhibitors of activation of these transcription factors: pyrrolidine dithiocarbamate (PDTC), parthenolide and curcumin, indicate that NFkappaB and AP-1 cannot be solely responsible for the cytokine induced expression of stromelysin-1 gene in mouse astrocytes.	Curcumin	142-150	matrix metallopeptidase 3	Mus musculus	252-265
30599890-3	2019	Although many studies focused on the PI3K, MAP kinase and NF-kappaB pathways, a thorough investigation of modulation of players in the apoptotic and Wnt/beta-catenin signaling pathway by curcumin and quercetin has not been done.	Curcumin	187-195	catenin beta 1	Homo sapiens	153-165
30599890-10	2019	Further investigation of the mechanism of action of curcumin and quercetin in melanoma cells, A375, suggested that inhibition of cell proliferation occurred through down-regulation of Wnt/beta-catenin signaling pathway proteins, DVL2, beta-catenin, cyclin D1, Cox2, and Axin2.	Curcumin	52-60	catenin beta 1	Homo sapiens	188-200
18718065-0	2008	[Antiproliferative effect of curcumin combined with cyclophosmide on the growth of human lymphoma cell line HT/CTX with drug resistance and its relation with FA/BRCA pathway].	Curcumin	29-37	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	111-114
18718065-1	2008	The aim of this study was to investigate the antiproliferative effect of curcumin combined with cyclophosmide on the growth of human lymphoma cell line HT/CTX with drug resistance and its relation with FA/BRCA pathway.	Curcumin	73-81	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	155-158
30599890-10	2019	Further investigation of the mechanism of action of curcumin and quercetin in melanoma cells, A375, suggested that inhibition of cell proliferation occurred through down-regulation of Wnt/beta-catenin signaling pathway proteins, DVL2, beta-catenin, cyclin D1, Cox2, and Axin2.	Curcumin	52-60	catenin beta 1	Homo sapiens	235-247
18718065-5	2008	The results indicated that the combination of curcumin with CTX had an additional synergistic inhibitory effects on the proliferation and cell cycle distribution of HT/CTX cells.	Curcumin	46-54	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	168-171
18718065-6	2008	The curcumin could enhance toxicity of CTX on HT/CTX cells through inhibition of FA/BRCA pathway which was realized by suppression of FANCD2 monoubiquitination.	Curcumin	4-12	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	39-42
12927811-0	2003	Changes in temperature modulate heme oxygenase-1 induction by curcumin in renal epithelial cells.	Curcumin	62-70	heme oxygenase 1	Homo sapiens	32-48
30599890-10	2019	Further investigation of the mechanism of action of curcumin and quercetin in melanoma cells, A375, suggested that inhibition of cell proliferation occurred through down-regulation of Wnt/beta-catenin signaling pathway proteins, DVL2, beta-catenin, cyclin D1, Cox2, and Axin2.	Curcumin	52-60	axin 2	Homo sapiens	270-275
12890714-8	2003	Furthermore, curcumin inhibited the increases in lung MPO activity, TGF-beta1 expression, lung hydroxyproline content, expression of type I collagen and c-Jun protein in amiodarone rats.	Curcumin	13-21	myeloperoxidase	Rattus norvegicus	54-57
18718065-6	2008	The curcumin could enhance toxicity of CTX on HT/CTX cells through inhibition of FA/BRCA pathway which was realized by suppression of FANCD2 monoubiquitination.	Curcumin	4-12	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	49-52
18718065-7	2008	The curcumin combined with CTX could increase apoptosis inducing effect on HT/CTX cells, while the curcumin or CTX alone did not showed this effect, and without inhibition of FA/BRCA pahtway.	Curcumin	4-12	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	78-81
18718065-7	2008	The curcumin combined with CTX could increase apoptosis inducing effect on HT/CTX cells, while the curcumin or CTX alone did not showed this effect, and without inhibition of FA/BRCA pahtway.	Curcumin	4-12	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	78-81
30599890-12	2019	CONCLUSION: These results demonstrate that curcumin and quercetin inhibit cancer cell proliferation synergistically and Wnt/beta-catenin signaling and apoptotic pathways are partly responsible for antiproliferative activities.	Curcumin	43-51	catenin beta 1	Homo sapiens	124-136
18718065-8	2008	It is concluded that combination of curcumin and CTX produces synergistic effects and reverses multiple drug resistance of HT/CTX cells effectively.	Curcumin	36-44	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	126-129
30599892-0	2019	Curcumin ameliorates atherosclerosis in apolipoprotein E deficient asthmatic mice by regulating the balance of Th2/Treg cells.	Curcumin	0-8	heart and neural crest derivatives expressed 2	Mus musculus	111-114
18593918-4	2008	Significantly, curcumin-mediated inhibition of RON expression resulted in the blockade of RON ligand, MSP-induced invasion of breast cancer cells.	Curcumin	15-23	macrophage stimulating 1	Homo sapiens	102-105
12818219-6	2003	Addition of curcumin (an inhibitor of nuclear transcription for the inflammatory cascade) abrogated expression of adhesion molecules at a statistically significant level for ICAM-1 in 8/10 PVE, and for E-selectin in all 10 PVE.	Curcumin	12-20	selectin E	Homo sapiens	202-212
12570874-0	2003	Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	23-39
30599892-6	2019	After the 8-week treatment with curcumin, the lesion areas in the aortic root in asthmatic mice significantly improved, and the elevated Th2 and Th17 cells significantly decreased, but Tregs markedly increased.	Curcumin	32-40	heart and neural crest derivatives expressed 2	Mus musculus	137-140
12570874-4	2003	Recently, the natural antioxidants curcumin and caffeic acid phenethyl ester (CAPE) have been identified as potent inducers of haem oxygenase-1 (HO-1), a redox-sensitive inducible protein that provides protection against various forms of stress.	Curcumin	35-43	heme oxygenase 1	Homo sapiens	127-143
12570874-4	2003	Recently, the natural antioxidants curcumin and caffeic acid phenethyl ester (CAPE) have been identified as potent inducers of haem oxygenase-1 (HO-1), a redox-sensitive inducible protein that provides protection against various forms of stress.	Curcumin	35-43	heme oxygenase 1	Homo sapiens	145-149
30599892-10	2019	CONCLUSION: Curcumin ameliorated the aggravation of atherosclerotic lesions and stabilised plaque by modulating the balance of Th2/Tregs in asthmatic apoE-/- mice.	Curcumin	12-20	heart and neural crest derivatives expressed 2	Mus musculus	127-130
12570874-7	2003	From several lines of investigation we also report that curcumin (and, by inference, CAPE) stimulates ho-1 gene activity by promoting inactivation of the Nrf2-Keap1 complex, leading to increased Nrf2 binding to the resident ho-1 AREs.	Curcumin	56-64	heme oxygenase 1	Homo sapiens	102-106
30534000-6	2018	Curcumin also activated the expression of apoptotic proteins, such as polyADP ribose polymerase, caspase-3, and caspase-9.	Curcumin	0-8	caspase 9	Homo sapiens	112-121
19080373-7	2008	10, 25, 50 micromol/L Curcumin inhibited SiO(2)-induced PAI-1 protein expression (inhibition ratio: 20%, 63%, 65%; P &lt; 0.05).	Curcumin	22-30	serpin family E member 1	Homo sapiens	56-61
31949668-0	2018	Curcumin suppresses gastric cancer biological activity by regulation of miRNA-21: an in vitro study.	Curcumin	0-8	microRNA 21	Homo sapiens	72-80
18439772-0	2008	Curcuma drugs and curcumin regulate the expression and function of P-gp in Caco-2 cells in completely opposite ways.	Curcumin	18-26	phosphoglycolate phosphatase	Homo sapiens	67-71
12770926-8	2003	5 Curcumin also reduced the levels of nitric oxide (NO) and O(2)(-) associated with the favourable expression of Th1 and Th2 cytokines and inducible NO synthase.	Curcumin	2-10	heart and neural crest derivatives expressed 2	Mus musculus	121-124
31949668-1	2018	OBJECTIVE: The aim of this study was to explain the effects of curcumin to depress gastric cancer biological activity by regulation miRNA-21 an in in vitro study.	Curcumin	63-71	microRNA 21	Homo sapiens	132-140
18439772-7	2008	Interestingly, contrary to Curcumas, curcumin treatment inhibited the activity of P-gp with a decrease in P-gp protein and MDR1 mRNA expression levels.	Curcumin	37-45	phosphoglycolate phosphatase	Homo sapiens	82-86
18439772-7	2008	Interestingly, contrary to Curcumas, curcumin treatment inhibited the activity of P-gp with a decrease in P-gp protein and MDR1 mRNA expression levels.	Curcumin	37-45	phosphoglycolate phosphatase	Homo sapiens	106-110
12929584-5	2003	The results demonstrated that gene expression (NAT1 mRNA) in human colon tumor cells was inhibited by curcumin.	Curcumin	102-110	N-acetyltransferase 1	Homo sapiens	47-51
31949668-9	2018	CONCLUSION: Curcumin had anti-tumor effects to gastric cancer via ion of miRNA-21 by regulation of the PTEN/PI3K/AKT pathway.	Curcumin	12-20	microRNA 21	Homo sapiens	73-81
18439772-10	2008	Caution should be exercised when Curcumas or curcumin are to be consumed with drugs that are P-gp substrates because Curcumas and curcumin might regulate the function of P-gp in completely opposite ways.	Curcumin	45-53	phosphoglycolate phosphatase	Homo sapiens	170-174
18439772-10	2008	Caution should be exercised when Curcumas or curcumin are to be consumed with drugs that are P-gp substrates because Curcumas and curcumin might regulate the function of P-gp in completely opposite ways.	Curcumin	130-138	phosphoglycolate phosphatase	Homo sapiens	93-97
31949668-9	2018	CONCLUSION: Curcumin had anti-tumor effects to gastric cancer via ion of miRNA-21 by regulation of the PTEN/PI3K/AKT pathway.	Curcumin	12-20	phosphatase and tensin homolog	Homo sapiens	103-107
18439772-10	2008	Caution should be exercised when Curcumas or curcumin are to be consumed with drugs that are P-gp substrates because Curcumas and curcumin might regulate the function of P-gp in completely opposite ways.	Curcumin	130-138	phosphoglycolate phosphatase	Homo sapiens	170-174
18430363-11	2008	CONCLUSION: Curcumin inhibits ox-LDL-induced cholesterol accumulation in cultured VSMC through increasing the caveolin-1 expression via the inhibition of nuclear translocation of SREBP-1.	Curcumin	12-20	caveolin 1, caveolae protein	Mus musculus	110-120
18430363-11	2008	CONCLUSION: Curcumin inhibits ox-LDL-induced cholesterol accumulation in cultured VSMC through increasing the caveolin-1 expression via the inhibition of nuclear translocation of SREBP-1.	Curcumin	12-20	sterol regulatory element binding transcription factor 1	Mus musculus	179-186
12806293-9	2003	Treatment of oxidative-stressed cultures with either curcumin, a MAPKKK pathway inhibitor, or PD-098059, a MEK1 inhibitor, blocked loss of neurons via the JNK/c-Jun apoptotic pathway.	Curcumin	53-61	mitogen-activated protein kinase kinase kinase 4	Homo sapiens	65-71
12473670-9	2003	Moreover, our data revealed that curcumin inhibited the OPN-induced translocation of p65, NF kappa B-DNA binding, and NF kappa B transcriptional activity.	Curcumin	33-41	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	85-88
30396035-0	2018	Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1beta production.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	55-60
18321868-4	2008	Dietary pretreatment of mice with chemopreventive doses of curcumin showed significant inhibition of B[a]P-induced enzyme activity, protein and messenger RNA (mRNA) levels of cytochrome P450 1A1/1A2 in liver and lungs.	Curcumin	59-67	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	175-198
30396035-3	2018	OBJECTIVE: The present study was to investigate the protective effects of curcumin on dextran sulfate sodium (DSS)-induced colitis through inhibiting NLRP3 inflammasome activation and IL-1beta production.	Curcumin	74-82	NLR family, pyrin domain containing 3	Mus musculus	150-155
30396035-4	2018	METHODS: LPS-primed macrophages were treated with curcumin prior to DSS triggering NLRP3 inflammasome activation, IL-1beta secretion and ASC oligomerization were observed.	Curcumin	50-58	NLR family, pyrin domain containing 3	Mus musculus	83-88
30396035-9	2018	RESULTS: NLRP3 inflammasome activation was dramatically inhibited by curcumin in DSS-stimulated macrophages, as evidenced by decreased IL-1beta secretion, less caspase-1 activation and ASC specks.	Curcumin	69-77	NLR family, pyrin domain containing 3	Mus musculus	9-14
30396035-10	2018	Mechanistically, curcumin prevented DSS-induced K+ efflux, intracellular ROS formation and cathepsin B release, three major cellular events mediating NLRP3 inflammasome activation.	Curcumin	17-25	NLR family, pyrin domain containing 3	Mus musculus	150-155
18473931-2	2008	Whereas curcumin and emodin can act via inhibition of COP9 signalosome-associated kinases, taurolidine blocks protein biosynthesis.	Curcumin	8-16	COP9 signalosome subunit 8	Homo sapiens	54-58
12633846-0	2003	Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases.	Curcumin	56-64	caspase 9	Homo sapiens	171-179
12633846-5	2003	Moreover, heat shock reduced curcumin-induced activation of caspases 9 and 3 but not 8.	Curcumin	29-37	caspase 9	Homo sapiens	60-76
12466962-0	2002	Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells.	Curcumin	87-95	catenin beta 1	Homo sapiens	0-12
12466962-4	2002	Results showed that curcumin treatment causes p53- and p21-independent G(2)/M phase arrest and apoptosis in HCT-116(p53(+/+)), HCT-116(p53(-/-)) and HCT-116(p21(-/-)) cell lines.	Curcumin	20-28	H3 histone pseudogene 16	Homo sapiens	55-58
30396035-13	2018	Furthermore, blockage of NLRP3 inflammasome activation in vivo with specific NLRP3 inhibitor abrogated the further inhibitory effect of curcumin on DSS-induced colitis.	Curcumin	136-144	NLR family, pyrin domain containing 3	Mus musculus	25-30
12466962-4	2002	Results showed that curcumin treatment causes p53- and p21-independent G(2)/M phase arrest and apoptosis in HCT-116(p53(+/+)), HCT-116(p53(-/-)) and HCT-116(p21(-/-)) cell lines.	Curcumin	20-28	H3 histone pseudogene 16	Homo sapiens	157-160
12466962-5	2002	We further investigated the association of the beta-catenin-mediated c-Myc expression and the cell-cell adhesion pathways in curcumin-induced G(2)/M arrest and apoptosis in HCT-116 cells.	Curcumin	125-133	catenin beta 1	Homo sapiens	47-59
30396035-13	2018	Furthermore, blockage of NLRP3 inflammasome activation in vivo with specific NLRP3 inhibitor abrogated the further inhibitory effect of curcumin on DSS-induced colitis.	Curcumin	136-144	NLR family, pyrin domain containing 3	Mus musculus	77-82
12466962-8	2002	The decreased transactivation of beta-catenin in curcumin-treated HCT-116 cells was unpreventable by caspase-3 inhibitor Z-DEVD-fmk, even though the curcumin-induced cleavage of beta-catenin was blocked in Z-DEVD-fmk pretreated cells.	Curcumin	49-57	catenin beta 1	Homo sapiens	33-45
30396035-14	2018	CONCLUSION: Curcumin could strongly suppress DSS-induced NLRP3 inflammsome activation and alleviate DSS-induced colitis in mice, thus it may be a promising candidate drug in clinical application for IBD therapy.	Curcumin	12-20	NLR family, pyrin domain containing 3	Mus musculus	57-62
12466962-8	2002	The decreased transactivation of beta-catenin in curcumin-treated HCT-116 cells was unpreventable by caspase-3 inhibitor Z-DEVD-fmk, even though the curcumin-induced cleavage of beta-catenin was blocked in Z-DEVD-fmk pretreated cells.	Curcumin	49-57	catenin beta 1	Homo sapiens	178-190
12466962-8	2002	The decreased transactivation of beta-catenin in curcumin-treated HCT-116 cells was unpreventable by caspase-3 inhibitor Z-DEVD-fmk, even though the curcumin-induced cleavage of beta-catenin was blocked in Z-DEVD-fmk pretreated cells.	Curcumin	149-157	catenin beta 1	Homo sapiens	33-45
18187158-7	2008	Moreover, ODC overexpression prevented cytochrome c release and the activation of caspase-9 and caspase-3 following curcumin treatment.	Curcumin	116-124	caspase 9	Homo sapiens	82-91
17965732-9	2008	Curcumin suppressed gene expression of Toll-like receptor-4, leading to the inhibition of NF-kappaB.	Curcumin	0-8	toll like receptor 4	Homo sapiens	39-59
12466962-8	2002	The decreased transactivation of beta-catenin in curcumin-treated HCT-116 cells was unpreventable by caspase-3 inhibitor Z-DEVD-fmk, even though the curcumin-induced cleavage of beta-catenin was blocked in Z-DEVD-fmk pretreated cells.	Curcumin	149-157	catenin beta 1	Homo sapiens	178-190
29923222-0	2018	Effects of curcumin on NF-kappaB, AP-1, and Wnt/beta-catenin signaling pathway in hepatitis B virus infection.	Curcumin	11-19	catenin beta 1	Homo sapiens	48-60
12466962-9	2002	The curcumin treatment also induced caspase-3-mediated degradation of cell-cell adhesion proteins beta-catenin, E-cadherin and APC, which were linked with apoptosis, and this degradation was prevented with the caspase-3 inhibitor.	Curcumin	4-12	catenin beta 1	Homo sapiens	98-110
18006147-5	2008	This response might be associated with the inhibition of the phosphatidyinositol 3-kinase (PI3K)/Akt/nuclear factor-kappa B (NF-kappa B) signaling pathway by curcumin.	Curcumin	158-166	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	61-89
29923222-7	2018	It has been showed that curcumin exerts its therapeutic effects on HBV patients via targeting a variety of cellular and molecular pathways such as Wnt/beta-catenin, Ap1, STAT3, MAPK, and NF-kappaB signaling.	Curcumin	24-32	catenin beta 1	Homo sapiens	151-163
29923222-9	2018	Moreover, we highlighted main signaling pathways (eg, NF-kappaB, AP1, and Wnt/beta-catenin signaling) which affected by curcumin in HBV infections.	Curcumin	120-128	catenin beta 1	Homo sapiens	78-90
30292723-6	2018	Curcumin activated AMPK and JNK1, which phosphorylated Bcl-2 and Bim and subsequently disrupted their interactions with Beclin1, thereby promoting autophagy and alleviating apoptosis respectively.	Curcumin	0-8	beclin 1, autophagy related	Mus musculus	120-127
18396784-3	2008	In the present study, we investigated the effects of curcumin on WEHI-3 in BALB/c mice and the results indicated that curcumin reduces the percentage of Mac-3 marker, which is the precursor of macrophage.	Curcumin	118-126	lysosomal-associated membrane protein 2	Mus musculus	153-158
12324474-5	2002	Both the COP9 signalosome- associated kinase and 5/6-kinase are inhibited by curcumin.	Curcumin	77-85	COP9 signalosome subunit 8	Homo sapiens	9-13
30741618-8	2018	Our findings showed the protective effect of Curcumin in I/R injury is associated with suppressing NF-kappaB mediating inflammation by activating JAK2/STAT3 signal pathway.	Curcumin	45-53	signal transducer and activator of transcription 3	Rattus norvegicus	151-156
31516880-5	2018	In this study, we evaluated the effects of curcumin treatment on the regulation of IL-4 and IL-13, DUOX1 &amp; 2 genes as well as the pathological changes developed by this treatment.	Curcumin	43-51	methionyl aminopeptidase 2	Rattus norvegicus	106-112
18227041-7	2008	Curcumin treatment resulted in significantly decreased DAI, CMDI, HS and lowered activities of D-lactate, ICAM-1 and MPO in comparison with the model group (P&lt;0.01).	Curcumin	0-8	myeloperoxidase	Rattus norvegicus	117-120
12427831-8	2002	Furthermore, AP-1 inhibition, with curcumin or c-fos antisense oligonucleotide, reduced bim expression.	Curcumin	35-43	BCL2 like 11	Homo sapiens	88-91
31516880-13	2018	Treatment with curcumin downregulated the expression of IL-4, IL4Ra1, DUOX1 &amp; 2.	Curcumin	15-23	methionyl aminopeptidase 2	Rattus norvegicus	77-83
30327711-12	2018	Treatment of cultured human artery endothelial cells with curcumin induced the HO-1 expression through the activation of nuclear factor-E2-related factor 2 (Nrf2) and an antioxidant responsive element via the p38 MAPK signalling pathway.	Curcumin	58-66	heme oxygenase 1	Homo sapiens	79-83
32002947-10	2018	The findings also suggested curcumin"s potential in protecting HT22 cells against acrolein through regulating the BDNF/TrkB signaling.	Curcumin	28-36	brain derived neurotrophic factor	Mus musculus	114-118
12104041-5	2002	Increasing concentrations of curcumin caused a steady decrease in the level of hTERT mRNA in MCF-7 cells whereas the level of hTER and c-myc mRNAs remained the same.	Curcumin	29-37	telomerase reverse transcriptase	Homo sapiens	79-84
12104041-5	2002	Increasing concentrations of curcumin caused a steady decrease in the level of hTERT mRNA in MCF-7 cells whereas the level of hTER and c-myc mRNAs remained the same.	Curcumin	29-37	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	135-140
12104041-6	2002	Our results suggest that curcumin inhibits telomerase activity by down-regulating hTERT expression in breast cancer cells and this down-regulation is not through the c-myc pathway.	Curcumin	25-33	telomerase reverse transcriptase	Homo sapiens	82-87
12220536-3	2002	Curcumin treated with CYP 2D6, CYP1A1, or CYP1A2 induced DNA damage in the presence of Cu(II).	Curcumin	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	31-37
12220536-3	2002	Curcumin treated with CYP 2D6, CYP1A1, or CYP1A2 induced DNA damage in the presence of Cu(II).	Curcumin	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	42-48
12118335-0	2002	Curcumin inhibits cell cycle progression of immortalized human umbilical vein endothelial (ECV304) cells by up-regulating cyclin-dependent kinase inhibitor, p21WAF1/CIP1, p27KIP1 and p53.	Curcumin	0-8	cyclin dependent kinase inhibitor 1B	Homo sapiens	171-178
12118335-3	2002	Curcumin was found to induce G0/G1 and/or G2/M phase cell cycle arrest, up-regulate CDKIs, p21WAF1/CIP1, p27KIP1, and p53, and slightly down-regulate cyclin B1 and cdc2 in ECV304 cells.	Curcumin	0-8	cyclin dependent kinase inhibitor 1B	Homo sapiens	105-112
12118335-3	2002	Curcumin was found to induce G0/G1 and/or G2/M phase cell cycle arrest, up-regulate CDKIs, p21WAF1/CIP1, p27KIP1, and p53, and slightly down-regulate cyclin B1 and cdc2 in ECV304 cells.	Curcumin	0-8	cyclin B1	Homo sapiens	150-159
18946510-3	2008	The recent finding that various polyphenols modulate Glo1 activity has prompted us to assess curcumin"s potency as an Glo1 inhibitor.	Curcumin	93-101	glyoxalase I	Homo sapiens	118-122
18946510-5	2008	Results of enzyme kinetics revealed that curcumin, compared to the polyphenols quercetin, myricetin, kaempferol, luteolin and rutin, elicited a stronger competitive inhibitory effect on Glo1 (K(i) = 5.1+/-1.4 microM).	Curcumin	41-49	glyoxalase I	Homo sapiens	186-190
18946510-8	2008	Curcumin decreased D-lactate release by tumor cells, another clue for inhibition of intracellular Glo1.	Curcumin	0-8	glyoxalase I	Homo sapiens	98-102
18946510-9	2008	CONCLUSIONS/SIGNIFICANCE: The results described herein provide new insights into curcumin"s biological activities as they indicate that inhibition of Glo1 by curcumin may result in non-tolerable levels of MGO and GSH, which, in turn, modulate various metabolic cellular pathways including depletion of cellular ATP and GSH content.	Curcumin	81-89	glyoxalase I	Homo sapiens	150-154
18946510-9	2008	CONCLUSIONS/SIGNIFICANCE: The results described herein provide new insights into curcumin"s biological activities as they indicate that inhibition of Glo1 by curcumin may result in non-tolerable levels of MGO and GSH, which, in turn, modulate various metabolic cellular pathways including depletion of cellular ATP and GSH content.	Curcumin	158-166	glyoxalase I	Homo sapiens	150-154
18302884-6	2008	RESULTS: The nucleoprotein expression of c-jun and c-fos in 10 and 20 micromol/L Curcumin prevention group (1.150 +/- 0.020, 1.010 +/- 0.108, 80.430 +/- 0.023, 0.256 +/- 0.015) were lower than those in silica-stimulated group (1.550 +/- 0.029, 0.860 +/- 0.036) (P &lt; 0.01).	Curcumin	81-89	FBJ osteosarcoma oncogene	Mus musculus	51-56
12118335-3	2002	Curcumin was found to induce G0/G1 and/or G2/M phase cell cycle arrest, up-regulate CDKIs, p21WAF1/CIP1, p27KIP1, and p53, and slightly down-regulate cyclin B1 and cdc2 in ECV304 cells.	Curcumin	0-8	cyclin dependent kinase 1	Homo sapiens	164-168
29887570-4	2018	Furthermore, our real-time PCR, Western blot, and 22R-OHC/pregnenolone supplementing experiment data demonstrated that curcumin suppressed 8-br-cAMP-induced steroidogenesis in Leydig cells by inhibiting the expression of StAR and Cyp11a1.	Curcumin	119-127	steroidogenic acute regulatory protein	Mus musculus	221-225
12408761-3	2002	The effect of curcumin on the expression of c-myc, bcl-2, mutant-type p53 and Fas protein and mRNA was studied by flow cytometry (FCM) and reverse transcription-polymerase chain reaction (RT-PCR).	Curcumin	14-22	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	44-49
12408761-8	2002	The expression of c-myc, bcl-2, mutant-type p53 protein and mRNA was decreased sharply in CA46 cells treated with curcumin, while Fas protein and mRNA was increased.	Curcumin	114-122	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-23
12408761-9	2002	CONCLUSION: Curcumin is able to inhibit the proliferation of CA46 cells and induce the cell apoptosis by down-regulating the expression of c-myc, bcl-2, mutant-type p53 and up-regulating the expression of Fas.	Curcumin	12-20	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	139-144
17975885-10	2007	Given that GSTM1a-1a and GSTP1-1 are present in the intestinal epithelial cells, it can be concluded that efficient glutathione conjugation of curcumin may already occur in the enterocytes, followed by an efficient excretion of these glutathione conjugates to the lumen, thereby reducing the bioavailability of (unconjugated) curcumin.	Curcumin	143-151	glutathione S-transferase pi 1	Homo sapiens	25-32
17975885-11	2007	In conclusion, the present study identifies the nature of the diastereoisomeric monoglutathionyl curcumin conjugates, CURSG-1 and CURSG-2 formed in biological systems, and reveals that conjugate formation is catalyzed by GSTM1a-1a, GSTA1-1, and/or GSTP1-1 with different stereoselective preference.	Curcumin	97-105	glutathione S-transferase pi 1	Homo sapiens	248-255
17786026-0	2007	Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy.	Curcumin	62-70	ribosomal protein S6 kinase B1	Homo sapiens	22-28
29887570-6	2018	On the contrary, the real-time PCR results showed that curcumin suppressed 8-br-cAMP-induced expression of Nr5a1 and Fos, which are crucial for cAMP-stimulated StAR and Cyp11a1 expression in Leydig cells.	Curcumin	55-63	FBJ osteosarcoma oncogene	Mus musculus	117-120
11592943-0	2001	Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cells.	Curcumin	48-56	heme oxygenase 1	Homo sapiens	13-29
29887570-6	2018	On the contrary, the real-time PCR results showed that curcumin suppressed 8-br-cAMP-induced expression of Nr5a1 and Fos, which are crucial for cAMP-stimulated StAR and Cyp11a1 expression in Leydig cells.	Curcumin	55-63	steroidogenic acute regulatory protein	Mus musculus	160-164
29887570-7	2018	Collectively, our data demonstrated that curcumin may suppress cAMP-induced steroidogenesis in mouse Leydig cells by down-regulating Nr5a1/Fos-controlled StAR and Cyp11a1 expression independently of the PKA-CREB signaling pathway.	Curcumin	41-49	FBJ osteosarcoma oncogene	Mus musculus	139-142
29887570-7	2018	Collectively, our data demonstrated that curcumin may suppress cAMP-induced steroidogenesis in mouse Leydig cells by down-regulating Nr5a1/Fos-controlled StAR and Cyp11a1 expression independently of the PKA-CREB signaling pathway.	Curcumin	41-49	steroidogenic acute regulatory protein	Mus musculus	154-158
30138353-6	2018	Simultaneously, curcumin down regulated spermidine/spermine N1-acetyltransferase (SSAT) activity and the biosynthetic enzymes ODC and S-adenosylmethionine decarboxylase (SAMDC), thereby diminishing intracellular polyamine pools.	Curcumin	16-24	adenosylmethionine decarboxylase 1	Homo sapiens	134-168
17662242-0	2007	Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina.	Curcumin	10-18	vascular endothelial growth factor A	Rattus norvegicus	44-78
17662242-4	2007	In this study, we evaluated whether curcumin and its dietary source turmeric can inhibit VEGF expression in strepotzotocin (STZ)-induced diabetic rat retina.	Curcumin	36-44	vascular endothelial growth factor A	Rattus norvegicus	89-93
17662242-11	2007	Notably, feeding of curcumin and turmeric to diabetic rats inhibited expression of VEGF.	Curcumin	20-28	vascular endothelial growth factor A	Rattus norvegicus	83-87
17979888-9	2007	Curcumin increased IFN-alpha-induced IL-10 and IFNAR1 expression.	Curcumin	0-8	interferon alpha and beta receptor subunit 1	Homo sapiens	47-53
11346483-5	2001	Significantly lower concentrations of curcumin(s) than isothiocyanates achieved 50% inhibition of activity of CYP 1A1 and 1A2, while concentrations of C (4 microM), bdmC (2.5 microM) required to inhibit CYP 2B1 were slightly higher than that of PEITC (1.3 microM), suggesting curcumin(s) to be effective inhibitors of CYP 2B1 as well.	Curcumin	38-46	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	110-117
11346483-5	2001	Significantly lower concentrations of curcumin(s) than isothiocyanates achieved 50% inhibition of activity of CYP 1A1 and 1A2, while concentrations of C (4 microM), bdmC (2.5 microM) required to inhibit CYP 2B1 were slightly higher than that of PEITC (1.3 microM), suggesting curcumin(s) to be effective inhibitors of CYP 2B1 as well.	Curcumin	276-284	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	110-117
11346483-7	2001	These results suggest that turmeric/curcumin(s) as in the case of isothiocyanate, PEITC, are likely to inhibit activation of carcinogens metabolized by CYP450 isozymes, namely, CYP 1A1, 1A2 and 2B1.	Curcumin	36-44	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	177-184
30138353-6	2018	Simultaneously, curcumin down regulated spermidine/spermine N1-acetyltransferase (SSAT) activity and the biosynthetic enzymes ODC and S-adenosylmethionine decarboxylase (SAMDC), thereby diminishing intracellular polyamine pools.	Curcumin	16-24	adenosylmethionine decarboxylase 1	Homo sapiens	170-175
30304108-9	2018	In the curcumin + alendronate group, BALP and CTx levels decreased and osteocalcin levels increased significantly at the end of study compared to the control and alendronate groups.	Curcumin	7-15	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	46-49
11350917-0	2001	Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels.	Curcumin	19-27	hematopoietic prostaglandin D synthase	Rattus norvegicus	31-56
11350917-8	2001	The curcumin diet did not alter any of the markers in the blood but increased hepatic GST by 16% and decreased colon M(1)G levels by 36% when compared with controls.	Curcumin	4-12	hematopoietic prostaglandin D synthase	Rattus norvegicus	86-89
17666914-6	2007	The expression of intracellular cell adhesion molecule (ICAM)-1, monocyte chemoattractant protein (MCP)-1, and interleukin (IL)-8 were attenuated by curcumin at both mRNA and protein level.	Curcumin	149-157	C-C motif chemokine ligand 2	Homo sapiens	65-105
28678551-0	2018	Nano-encapsulated metformin-curcumin in PLGA/PEG inhibits synergistically growth and hTERT gene expression in human breast cancer cells.	Curcumin	28-36	telomerase reverse transcriptase	Homo sapiens	85-90
17596214-7	2007	Curcumin-sensitized glioma cells to several clinically utilized chemotherapeutic agents (cisplatin, etoposide, camptothecin, and doxorubicin) and radiation, effects correlated with reduced expression of bcl-2 and IAP family members as well as DNA repair enzymes (MGMT, DNA-PK, Ku70, Ku80, and ERCC-1).	Curcumin	0-8	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	293-299
17277231-0	2007	Bax and Bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, Curcuma longa.	Curcumin	66-74	BCL2-antagonist/killer 1	Mus musculus	8-11
11322764-11	2001	Instead, curcumin enhanced expression of heat shock protein 70 (HSP70) in HK-2 cells under control conditions and after exposure to Stx1 or Stx2.	Curcumin	9-17	syntaxin 1A	Homo sapiens	132-136
11370761-6	2001	In addition, curcumin inhibits the activation of NFkappaB and the expression of c-jun, c-fos, c-myc and iNOS.	Curcumin	13-21	FBJ osteosarcoma oncogene	Mus musculus	87-92
11077049-7	2000	Curcumin blocked the disappearance of inhibitory kappaBalpha (IkappaBalpha) and p65 from the cytosolic fraction, and inhibited the phosphorylation of IkappaBalpha.	Curcumin	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	80-83
17277231-2	2007	The objective of this study was to examine the molecular mechanisms by which multidomain pro-apoptotic Bcl-2 family members Bax and Bak regulate curcumin-induced apoptosis using mouse embryonic fibroblasts (MEFs) deficient in Bax, Bak or both genes.	Curcumin	145-153	BCL2-antagonist/killer 1	Mus musculus	132-135
29880071-9	2018	Furthermore, compared with the BDL group, we observed an increase in IRS1 and a decrease in SOCS3 and STAT3 expression in the curcumin-treated BDL group (P&lt;0 05), indicating return of these parameters towards normalcy.	Curcumin	126-134	signal transducer and activator of transcription 3	Rattus norvegicus	102-107
17277231-3	2007	Curcumin treatment resulted an increase in the protein levels of both Bax and Bak, and mitochondrial translocation and activation of Bax in MEFs to trigger drop in mitochondrial membrane potential, cytosolic release of apoptogenic molecules [cytochrome c and second mitochondria-derived activator of caspases (Smac)/direct inhibitor of apoptosis protein-binding protein with low isoelectric point], activation of caspase-9 and caspase-3 and ultimately apoptosis.	Curcumin	0-8	BCL2-antagonist/killer 1	Mus musculus	78-81
17277231-4	2007	Furthermore, MEFs derived from Bax and Bak double-knockout (DKO) mice exhibited even greater protection against curcumin-induced release of cytochrome c and Smac, activation of caspase-3 and caspase-9 and induction of apoptosis compared with wild-type MEFs or single-knockout Bax(-/-) or Bak(-/-) MEFs.	Curcumin	112-120	BCL2-antagonist/killer 1	Mus musculus	39-42
17277231-4	2007	Furthermore, MEFs derived from Bax and Bak double-knockout (DKO) mice exhibited even greater protection against curcumin-induced release of cytochrome c and Smac, activation of caspase-3 and caspase-9 and induction of apoptosis compared with wild-type MEFs or single-knockout Bax(-/-) or Bak(-/-) MEFs.	Curcumin	112-120	BCL2-antagonist/killer 1	Mus musculus	288-291
11077049-8	2000	Furthermore, we showed that curcumin could inhibit the IkappaB kinase 1 (IKK1) and IkappaB kinase 2 (IKK2) activities induced by LPS, but tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin were less active.	Curcumin	28-36	conserved helix-loop-helix ubiquitous kinase	Mus musculus	55-71
11077049-8	2000	Furthermore, we showed that curcumin could inhibit the IkappaB kinase 1 (IKK1) and IkappaB kinase 2 (IKK2) activities induced by LPS, but tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin were less active.	Curcumin	28-36	conserved helix-loop-helix ubiquitous kinase	Mus musculus	73-77
11077049-8	2000	Furthermore, we showed that curcumin could inhibit the IkappaB kinase 1 (IKK1) and IkappaB kinase 2 (IKK2) activities induced by LPS, but tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin were less active.	Curcumin	28-36	inhibitor of kappaB kinase beta	Mus musculus	83-99
11077049-8	2000	Furthermore, we showed that curcumin could inhibit the IkappaB kinase 1 (IKK1) and IkappaB kinase 2 (IKK2) activities induced by LPS, but tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin were less active.	Curcumin	28-36	inhibitor of kappaB kinase beta	Mus musculus	101-105
17392282-0	2007	Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction.	Curcumin	0-8	signal transducer and activator of transcription 5A	Homo sapiens	57-64
17392282-9	2007	These entire phenomena could be reverted back by curcumin, indicating that this phytochemical restored the cytokine-dependent Jak-3/Stat-5a signaling pathway in T cells of tumor bearers.	Curcumin	49-57	Janus kinase 3	Homo sapiens	126-131
17392282-9	2007	These entire phenomena could be reverted back by curcumin, indicating that this phytochemical restored the cytokine-dependent Jak-3/Stat-5a signaling pathway in T cells of tumor bearers.	Curcumin	49-57	signal transducer and activator of transcription 5A	Homo sapiens	132-139
11077049-9	2000	These results suggest that curcumin may exert its anti-inflammatory and anti-carcinogenic properties by suppressing the activation of NFkappaB through inhibition of IKK activity.	Curcumin	27-35	conserved helix-loop-helix ubiquitous kinase	Mus musculus	165-168
30116377-7	2018	In conclusion, curcumin inhibited the proliferation of breast cancer cells and induced G2/M phase cell cycle arrest and apoptosis, which may be associated with the decrease of CDC25 and CDC2 and increase of P21 protein levels, as well as inhibition of the phosphorylation of Akt/mTOR and induction of the mitochondrial apoptotic pathway.	Curcumin	15-23	H3 histone pseudogene 16	Homo sapiens	207-210
29980703-3	2018	The plant-derived polyphenols, carnosol and curcumin, have been identified as candidate HO-1 inducers however there has been little investigation into their effects on human immune cells.	Curcumin	44-52	heme oxygenase 1	Homo sapiens	88-92
10996298-4	2000	Glutathionylated products of curcumin identified by FAB-MS and MALDI-MS included mono- and di-glutathionyl-adducts of curcumin as well as cyclic rearrangement products of GSH adducts of feruloylmethylketone (FMK) and feruloylaldehyde (FAL).	Curcumin	29-37	FA complementation group B	Homo sapiens	52-55
17332930-10	2007	Similarly, wild-type phosphatase and tensin homolog deleted from chromosome 10 (PTEN) enhanced curcumin-induced apoptosis and, in contrast, inactive PTEN (G129E and G129R) inhibited curcumin-induced apoptosis.	Curcumin	95-103	phosphatase and tensin homolog	Homo sapiens	80-84
17332930-10	2007	Similarly, wild-type phosphatase and tensin homolog deleted from chromosome 10 (PTEN) enhanced curcumin-induced apoptosis and, in contrast, inactive PTEN (G129E and G129R) inhibited curcumin-induced apoptosis.	Curcumin	182-190	phosphatase and tensin homolog	Homo sapiens	149-153
17332930-11	2007	Overexpression of constitutively active AKT inhibited curcumin-induced p53 translocation to mitochondria, and Smac release to cytoplasm, whereas inhibition of AKT by dominant negative AKT enhanced curcumin-induced p53 translocation to mitochondria and Smac release.	Curcumin	54-62	diablo IAP-binding mitochondrial protein	Homo sapiens	252-256
17148446-4	2007	We show that curcumin suppresses the differentiation agent-dependent activation of hINV gene expression and that an AP1 transcription factor DNA binding site in the hINV gene is required for this regulation.	Curcumin	13-21	leishmanolysin like peptidase	Homo sapiens	83-87
10918449-6	2000	Requirement of AP-1 for Gal-1-induced apoptosis was confirmed by the dose-dependent reduction on the level of DNA fragmentation observed when cells were pre-treated with curcumin (an inhibitor of AP-1 activation) before exposure to Gal-1.	Curcumin	170-178	galectin 1	Homo sapiens	24-29
10918449-6	2000	Requirement of AP-1 for Gal-1-induced apoptosis was confirmed by the dose-dependent reduction on the level of DNA fragmentation observed when cells were pre-treated with curcumin (an inhibitor of AP-1 activation) before exposure to Gal-1.	Curcumin	170-178	galectin 1	Homo sapiens	232-237
17148446-4	2007	We show that curcumin suppresses the differentiation agent-dependent activation of hINV gene expression and that an AP1 transcription factor DNA binding site in the hINV gene is required for this regulation.	Curcumin	13-21	leishmanolysin like peptidase	Homo sapiens	165-169
29980703-5	2018	We also characterised their effects in ex-vivo psoriasis PBMC and report that curcumin, but not carnosol, strongly reduces T cell proliferation and cytokine poly-functionality, with reduced expression of psoriatic cytokines IFNgamma, IL-17, GM-CSF and IL-22.	Curcumin	78-86	colony stimulating factor 2	Homo sapiens	241-247
17148446-6	2007	Curcumin treatment inhibits the novel protein kinase C-, Ras-, and MEKK1-dependent activation of hINV promoter activity and reduces the differentiation agent-dependent increase in AP1 factor level and DNA binding.	Curcumin	0-8	leishmanolysin like peptidase	Homo sapiens	97-101
17148446-8	2007	In addition, curcumin treatment reduces cell number, which is associated with a reduced cyclin and cdk1 levels.	Curcumin	13-21	proliferating cell nuclear antigen	Homo sapiens	88-94
30057672-5	2018	Curcumin has been reported to have neuroprotective properties in PD models induced by neurotoxins or genetic factors such as alpha-synuclein, PINK1, DJ-1, and LRRK2.	Curcumin	0-8	PTEN-induced putative kinase 1	Drosophila melanogaster	142-147
17148446-8	2007	In addition, curcumin treatment reduces cell number, which is associated with a reduced cyclin and cdk1 levels.	Curcumin	13-21	cyclin dependent kinase 1	Homo sapiens	99-103
17332326-0	2007	Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway.	Curcumin	0-8	ETS proto-oncogene 2, transcription factor	Homo sapiens	157-161
11775869-7	2000	Curcumin (AP-1 inhibitor), staurosporine (PKC inhibitor), and genistein (PTK inhibitor) all reduced AP-1-mediated PAI-1 mRNA expression induced by thrombin in cultured MCs.	Curcumin	0-8	serpin family E member 1	Homo sapiens	114-119
30057672-5	2018	Curcumin has been reported to have neuroprotective properties in PD models induced by neurotoxins or genetic factors such as alpha-synuclein, PINK1, DJ-1, and LRRK2.	Curcumin	0-8	dj-1beta	Drosophila melanogaster	149-153
10747850-6	2000	The relA-transfected cells showed constitutive NF-kappaB DNA binding activity that could not be inhibited by curcumin and did not show nuclear condensation and DNA fragmentation upon treatment with curcumin.	Curcumin	109-117	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	4-8
17569210-6	2007	Curcumin arrested the cell cycle by preventing the expression of cyclin D1, cdk-1 and cdc-25.	Curcumin	0-8	cyclin dependent kinase 1	Homo sapiens	76-81
17569210-6	2007	Curcumin arrested the cell cycle by preventing the expression of cyclin D1, cdk-1 and cdc-25.	Curcumin	0-8	cell division cycle 25C	Homo sapiens	86-92
10747850-7	2000	When a super-repressor form of IkappaB-alpha (known to inhibit NF-kappaB) was transfected transiently into relA-transfected cells, the cells were no longer resistant to curcumin.	Curcumin	169-177	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	107-111
29950857-0	2018	Curcumin suppresses the progression of laryngeal squamous cell carcinoma through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway.	Curcumin	0-8	microRNA 145	Homo sapiens	101-108
17177975-0	2007	Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway.	Curcumin	16-24	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	63-69
29950857-5	2018	The effects of miR-145 combined with curcumin on the phosphoinositol 1,3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway were detected by Western blot analysis.	Curcumin	37-45	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	53-79
17177975-5	2007	Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4.	Curcumin	15-23	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	127-133
29950857-7	2018	Curcumin administration upregulated miR-145 expression in LSCC cells in a dose-dependent manner.	Curcumin	0-8	microRNA 145	Homo sapiens	36-43
17143561-0	2007	Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	17-33
17143561-1	2007	Curcumin is a naturally occurring compound which is known to induce heme oxygenase 1 (HO-1), although the underlying mechanism has not been fully elucidated.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	68-84
10713700-11	2000	We found that transactivation of the c-met promoter by AP-1 can be blocked by Curcumin, an inhibitor of AP-1.	Curcumin	78-86	met proto-oncogene	Mus musculus	37-42
29950857-9	2018	Moreover, curcumin treatment reversed the enhanced effects on cell viability, migration and invasion and the inhibitory effects on apoptosis conferred by anti-miR-145 in LSCC cells.	Curcumin	10-18	microRNA 145	Homo sapiens	159-166
10713700-12	2000	Moreover, we found that the induction of the endogenous c-met gene by HGF is inhibited by the addition of Curcumin.	Curcumin	106-114	met proto-oncogene	Mus musculus	56-61
29950857-10	2018	Curcumin treatment dramatically aggravated miR-145-induced inhibition of the PI3K/Akt/mTOR pathway and reversed anti-miR-145-mediated activation of the PI3K/Akt/mTOR pathway in LSCC cells.	Curcumin	0-8	microRNA 145	Homo sapiens	43-50
29950857-10	2018	Curcumin treatment dramatically aggravated miR-145-induced inhibition of the PI3K/Akt/mTOR pathway and reversed anti-miR-145-mediated activation of the PI3K/Akt/mTOR pathway in LSCC cells.	Curcumin	0-8	microRNA 145	Homo sapiens	117-124
29950857-11	2018	Conclusion: Curcumin suppressed LSCC progression through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway.	Curcumin	12-20	microRNA 145	Homo sapiens	77-84
17143561-1	2007	Curcumin is a naturally occurring compound which is known to induce heme oxygenase 1 (HO-1), although the underlying mechanism has not been fully elucidated.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	86-90
17143561-2	2007	This study investigates in detail the mechanism of HO-1 induction by curcumin in human hepatoma cells.	Curcumin	69-77	heme oxygenase 1	Homo sapiens	51-55
29679536-3	2018	Curcumin formulated in SLN and in TPGS resulted in higher curcumin plasma levels in mice.	Curcumin	0-8	sarcolipin	Mus musculus	23-26
17143561-4	2007	Curcumin was found to induce HO-1 at doses of 10 to 25 microM.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	29-33
17143561-6	2007	This was reinforced by the finding that pretreatment with the antioxidants N-acetylcysteine, vitamin E and catalase prevented HO-1 induction by curcumin.	Curcumin	144-152	heme oxygenase 1	Homo sapiens	126-130
17143561-10	2007	A panel of kinase inhibitors was used to examine the contribution of MAP kinases to the induction of HO-1 by curcumin.	Curcumin	109-117	heme oxygenase 1	Homo sapiens	101-105
10674404-7	2000	Cumulatively, the data show that curcumin suppresses the induction of transcription factor Egr-1 and thereby modulates the expression of Egr-1-regulated genes in endothelial cells and fibroblasts.	Curcumin	33-41	early growth response 1	Homo sapiens	137-142
11237176-5	2000	Subsequently, curcumin inhibits the activation of NFkappaB and the expressions of c-jun, c-fos, c-myc and iNOS.	Curcumin	14-22	FBJ osteosarcoma oncogene	Mus musculus	89-94
17143561-13	2007	In conclusion, curcumin treatment results in ROS generation, activation of Nrf2 and MAP kinases and the inhibition of phosphatase activity in hepatocytes, and when curcumin is not administered in toxic doses, these multiple pathways converge to induce HO-1.	Curcumin	15-23	heme oxygenase 1	Homo sapiens	252-256
29679536-3	2018	Curcumin formulated in SLN and in TPGS resulted in higher curcumin plasma levels in mice.	Curcumin	58-66	sarcolipin	Mus musculus	23-26
29679536-9	2018	Given the efficacy of SLN-curc and the enhanced growth inhibitory effect when combined with chemotherapeutic drugs, we speculate that curcumin, when appropriately formulated, is a promising adjuvant agent for the treatment of HL and merits further evaluation.	Curcumin	134-142	sarcolipin	Mus musculus	22-25
30109004-0	2018	Curcumin-based pyrazoline analogues as selective inhibitors of human monoamine oxidase A.	Curcumin	0-8	monoamine oxidase A	Homo sapiens	69-88
20641872-12	2004	Curcumin, a natural compound studied for its antioxidant and anticancer properties, has shown have favorable brain permeability and Abeta plaque binding properties by fluorescence staining in brain section of APPsw transgenic mice (13).	Curcumin	0-8	amyloid beta (A4) precursor protein	Mus musculus	132-137
17004725-3	2006	In the present study, eight novel derivatives of curcumin and 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one (dehydrozingerone) were synthesized and their binding affinities for beta-amyloid (Abeta) aggregates were measured.	Curcumin	49-57	amyloid beta (A4) precursor protein	Mus musculus	175-195
10694226-4	2000	Similarly, curcumin inhibited ADR-induced increase in urinary excretion of N-acetyl-beta-D-glucosaminidase (a marker of renal tubular injury), fibronectin and glycosaminoglycan and plasma cholesterol.	Curcumin	11-19	fibronectin 1	Rattus norvegicus	143-154
11688958-6	2000	The downregulation of transcriptional AP-1 activity by curcumin as seen in the dual luciferase assay caused inhibition of LLC cell invasion through the repression of expression of the mRNAs for urokinase-type plasminogen activator (u-PA) and its receptor (u-PAR).	Curcumin	55-63	plasminogen activator, urokinase	Mus musculus	194-230
11688958-6	2000	The downregulation of transcriptional AP-1 activity by curcumin as seen in the dual luciferase assay caused inhibition of LLC cell invasion through the repression of expression of the mRNAs for urokinase-type plasminogen activator (u-PA) and its receptor (u-PAR).	Curcumin	55-63	plasminogen activator, urokinase	Mus musculus	232-236
10666014-8	2000	Similarly, curcumin prevented the rise in TBARS content in both BAL cell and lung tissue and MPO activity of the lung.	Curcumin	11-19	myeloperoxidase	Rattus norvegicus	93-96
10444406-11	1999	The stretch response of the MMP-1 gene was also completely inhibited by curcumin.	Curcumin	72-80	matrix metallopeptidase 1	Rattus norvegicus	28-33
16613838-0	2006	Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through CHOP-independent DR5 upregulation.	Curcumin	0-8	TNF receptor superfamily member 10b	Homo sapiens	128-131
29626606-6	2018	Moreover, curcumin markedly enhanced the translocation of Nrf2 from the cytoplasm to the nucleus, proved by the results of western blot and immunofluorescence, subsequently increased the expression of downstream factors such as heme oxygenase 1 (HO1) and NAD(P)H: quinone oxidoreductase 1 (NQO1) and prevented the decline of antioxidant enzyme activities.	Curcumin	10-18	heme oxygenase 1	Homo sapiens	228-244
16613838-2	2006	In this study, we showed that curcumin, a plant product containing the phenolic phytochemical, is a potent enhancer of TRAIL-induced apoptosis through upregulation of DR5 expression.	Curcumin	30-38	TNF receptor superfamily member 10b	Homo sapiens	167-170
16613838-3	2006	Both treatment with DR5/Fc chimeric protein and silencing of DR5 expression using small interfering RNA (siRNA) attenuated curcumin plus TRAIL-induced apoptosis, showing that the critical role of DR5 in this cell death.	Curcumin	123-131	TNF receptor superfamily member 10b	Homo sapiens	20-23
29626606-6	2018	Moreover, curcumin markedly enhanced the translocation of Nrf2 from the cytoplasm to the nucleus, proved by the results of western blot and immunofluorescence, subsequently increased the expression of downstream factors such as heme oxygenase 1 (HO1) and NAD(P)H: quinone oxidoreductase 1 (NQO1) and prevented the decline of antioxidant enzyme activities.	Curcumin	10-18	heme oxygenase 1	Homo sapiens	246-249
16613838-3	2006	Both treatment with DR5/Fc chimeric protein and silencing of DR5 expression using small interfering RNA (siRNA) attenuated curcumin plus TRAIL-induced apoptosis, showing that the critical role of DR5 in this cell death.	Curcumin	123-131	TNF receptor superfamily member 10b	Homo sapiens	61-64
16613838-3	2006	Both treatment with DR5/Fc chimeric protein and silencing of DR5 expression using small interfering RNA (siRNA) attenuated curcumin plus TRAIL-induced apoptosis, showing that the critical role of DR5 in this cell death.	Curcumin	123-131	TNF receptor superfamily member 10b	Homo sapiens	61-64
16613838-6	2006	Taken together, the present study demonstrates that curcumin enhances TRAIL-induced apoptosis by CHOP-independent upregulation of DR5.	Curcumin	52-60	TNF receptor superfamily member 10b	Homo sapiens	130-133
10101144-7	1999	Treatment of the plasma with beta-glucuronidase resulted in a decrease in the concentrations of these two putative conjugates and the concomitant appearance of tetrahydrocurcumin (THC) and curcumin, respectively.	Curcumin	170-178	glucuronidase, beta	Mus musculus	29-47
10363643-7	1999	Curcumin, a tumor suppressor and effector of AP-1 activation, is a potent inhibitor of the COP9 signalosome kinase activity with a Ki of about 10 microM.	Curcumin	0-8	COP9 signalosome subunit 8	Homo sapiens	91-95
29805641-0	2018	Targeted therapy of triple negative MDA-MB-468 breast cancer with curcumin delivered by epidermal growth factor-conjugated phospholipid nanoparticles.	Curcumin	66-74	epidermal growth factor	Homo sapiens	88-111
10363643-8	1999	Since curcumin is known as an inhibitor of the c-Jun N-terminal kinase (JNK) signaling pathway acting upstream of the MAP kinase kinase kinase level, one site of action of the COP9 signalosome might be proximal to regulators on that level.	Curcumin	6-14	COP9 signalosome subunit 8	Homo sapiens	176-180
9764755-1	1998	Curcumin, a major component of turmeric, a seasoning commonly used in Indian food, and a known antioxidant, anti-inflammatory and anti-carcinogenic agent, is a potent stimulator of the stress-induced expression of Hsp27, alphaB crystallin and Hsp70.	Curcumin	0-8	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	243-248
9764755-5	1998	Induction of Hsp27, alphaB crystallin and Hsp70 in the liver and adrenal glands of heat-stressed (42 degrees C for 20 min) rats was also enhanced by prior injection of curcumin (20 mg/kg body weight).	Curcumin	168-176	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	42-47
9698073-0	1998	Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells.	Curcumin	10-18	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-75
29805641-3	2018	In the present study, curcumin-loaded phospholipid nanoparticles (Cur-NPs) conjugated with epidermal growth factor (EGF) were prepared for specific targeting of EGF receptors overexpressed in TNBC.	Curcumin	22-30	epidermal growth factor	Homo sapiens	91-114
9698073-2	1998	Curcumin caused a rapid accumulation of cytochrome P450 1A1 (CYP1A1) mRNA in a time- and concentration-dependent manner, and CYP1A1 monooxygenase activity increased as measured by ethoxyresorufin-O-deethylation.	Curcumin	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	40-59
9698073-2	1998	Curcumin caused a rapid accumulation of cytochrome P450 1A1 (CYP1A1) mRNA in a time- and concentration-dependent manner, and CYP1A1 monooxygenase activity increased as measured by ethoxyresorufin-O-deethylation.	Curcumin	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	61-67
9698073-3	1998	Curcumin activated the DNA-binding capacity of the AhR for the xenobiotic responsive element of CYP1A1 as measured by the electrophoretic-mobility shift assay (EMSA).	Curcumin	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	96-102
9698073-5	1998	Although curcumin could activate the AhR on its own, it partially inhibited the activation of AhR, as measured by EMSA, and partially decreased the accumulation of CYP1A1 mRNA caused by the mammary carcinogen dimethylbenzanthracene (DMBA).	Curcumin	9-17	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	164-170
16932349-8	2006	Downregulation of Stat3 with small interfering RNA has no effect, whereas curcumin, an inhibitor of both Jak3 and the JNKs, almost completely blocks the VEGF production.	Curcumin	74-82	Janus kinase 3	Homo sapiens	105-109
17041101-7	2006	Analysis of the effects of the analogues on the expression of cancer-related genes usually affected by curcumin indicated that some induced the down-regulation of beta-catenin, Ki-ras, cyclin D1, c-Myc, and ErbB-2 at as low as one eighth the concentration at which curcumin normally has an effect.	Curcumin	103-111	catenin beta 1	Homo sapiens	163-175
17041101-7	2006	Analysis of the effects of the analogues on the expression of cancer-related genes usually affected by curcumin indicated that some induced the down-regulation of beta-catenin, Ki-ras, cyclin D1, c-Myc, and ErbB-2 at as low as one eighth the concentration at which curcumin normally has an effect.	Curcumin	103-111	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	196-201
9698073-6	1998	Curcumin competitively inhibited CYP1A1 activity in DMBA-treated cells and in microsomes isolated from DMBA-treated cells.	Curcumin	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	33-39
17041101-7	2006	Analysis of the effects of the analogues on the expression of cancer-related genes usually affected by curcumin indicated that some induced the down-regulation of beta-catenin, Ki-ras, cyclin D1, c-Myc, and ErbB-2 at as low as one eighth the concentration at which curcumin normally has an effect.	Curcumin	265-273	catenin beta 1	Homo sapiens	163-175
9698073-8	1998	These results suggest that the chemopreventive effect of curcumin may be due, in part, to its ability to compete with aryl hydrocarbons for both the AhR and CYP1A1.	Curcumin	57-65	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	157-163
29805641-3	2018	In the present study, curcumin-loaded phospholipid nanoparticles (Cur-NPs) conjugated with epidermal growth factor (EGF) were prepared for specific targeting of EGF receptors overexpressed in TNBC.	Curcumin	22-30	epidermal growth factor	Homo sapiens	116-119
9720770-24	1998	However, the alteration of the p53 mRNA level by curcumin (10(-5)-10(-4) M) treatment did not achieve significance.	Curcumin	49-57	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	31-34
17147887-1	2006	OBJECTIVE: To investigate the curcumin-induced the expression of IkappaBalpha in androgen-dependent (LNCaP) and androgen-independent (PC3) prostate cancer cells, and to study the mechanisms of curcumin on the proliferative inhibition of prostate cancer cells.	Curcumin	30-38	chromobox 8	Homo sapiens	134-137
17147887-2	2006	METHODS: After LNCaP and PC3 cells were affected by 10, 25, 50, 75, 100 micromol/L curcumin respectively, the cell activity was assayed with methyl thiazolyl tetrazolium (MTT) method at 5, 12 and 24 hours; Flow cytometry was adopted to observe the cell cycle of LNCaP and PC3 cells at 24 hours.	Curcumin	83-91	chromobox 8	Homo sapiens	25-28
17147887-4	2006	RESULTS: Curcumin obviously suppressed the proliferation of LNCaP and PC3 cells in does-dependent and time-dependent manners.	Curcumin	9-17	chromobox 8	Homo sapiens	70-73
29805641-3	2018	In the present study, curcumin-loaded phospholipid nanoparticles (Cur-NPs) conjugated with epidermal growth factor (EGF) were prepared for specific targeting of EGF receptors overexpressed in TNBC.	Curcumin	22-30	epidermal growth factor	Homo sapiens	161-164
17147887-5	2006	Curcumin could arrest the cell cycle of LNCaP and PC3 cells at G(2), M phase and then induce cell apoptosis.	Curcumin	0-8	chromobox 8	Homo sapiens	50-53
17147887-7	2006	However, the expression of IkappaBalpha in PC3 cells increased gradually with the inducement of concentration-increased curcumin (F = 31.618, P &lt; 0.05).	Curcumin	120-128	chromobox 8	Homo sapiens	43-46
17147887-8	2006	CONCLUSIONS: IkappaBalpha may play a role in the curcumin inducing apoptosis of PC3 cell, while the curcumin inducing apoptosis of LNCaP cells is by antioxidation and inhibiting metabolites formation in LNCaP cells.	Curcumin	49-57	chromobox 8	Homo sapiens	80-83
9675878-2	1998	Previous studies have shown that curcumin causes an increase in glutathione S-transferase (GST) activity in rodent liver which may contribute to its anti-cancer and anti-inflammatory activities.	Curcumin	33-41	hematopoietic prostaglandin D synthase	Rattus norvegicus	64-89
9675878-2	1998	Previous studies have shown that curcumin causes an increase in glutathione S-transferase (GST) activity in rodent liver which may contribute to its anti-cancer and anti-inflammatory activities.	Curcumin	33-41	hematopoietic prostaglandin D synthase	Rattus norvegicus	91-94
29805641-4	2018	NP formulation was performed by reacting EGF peptide with N-hydroxysuccinimide-Polyethylene Glycol-1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (NHS-PEG10000-DSPE), followed by efficient curcumin loading through lipid film hydration.	Curcumin	190-198	epidermal growth factor	Homo sapiens	41-44
9675878-4	1998	When rats were fed curcumin at doses from 1 to 500 mg kg-1 body weight daily for 14 days, the induction of hepatic GST activity towards 1-chloro-2,4-dinitrobenzene (CDNB) was found to be biphasic, with maximal induction of about 1.5 fold at the 25 to 50 mg kg-1 body weight dosage.	Curcumin	19-27	hematopoietic prostaglandin D synthase	Rattus norvegicus	115-118
9675878-7	1998	Western-blot analyses of liver cytosols revealed that curcumin caused a dose dependent induction of rGST 8-8, an isozyme which is known to display the highest activity towards 4-HNE, a highly toxic product of lipid peroxidation.	Curcumin	54-62	glutathione S-transferase alpha 4	Rattus norvegicus	100-108
29805641-10	2018	These results indicate that EGF-conjugated NHS-PEG10000-DSPE phospholipid NPs loaded with curcumin may be useful for treating TNBCs that overexpress the EGF receptor.	Curcumin	90-98	epidermal growth factor	Homo sapiens	28-31
9776860-7	1998	In situ hybridization and polymerase chain reaction analysis also showed an increase in the mRNA transcripts of transforming growth factor-beta1 and fibronectin in curcumin-treated wounds.	Curcumin	164-172	fibronectin 1	Rattus norvegicus	149-160
29899871-7	2018	The amine-functionalized and FA-conjugated curcumin-loaded, especially KCC-1 MSNs penetrated all cells organs and steadily released curcumin.	Curcumin	43-51	solute carrier family 12 member 4	Homo sapiens	71-76
8534266-0	1996	Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver.	Curcumin	11-19	hematopoietic prostaglandin D synthase	Rattus norvegicus	43-68
8534266-7	1996	Curcumin was also a potent inhibitor of glutathione S-transferase (GST) activity in cytosol from liver of rats treated with phenobarbital (PB), beta-naphthoflavone (beta NF) and pyrazole (Pyr), when measured towards 1-chloro-2,4-dinitrobenzene (CDNB) as substrate.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Rattus norvegicus	40-65
8534266-7	1996	Curcumin was also a potent inhibitor of glutathione S-transferase (GST) activity in cytosol from liver of rats treated with phenobarbital (PB), beta-naphthoflavone (beta NF) and pyrazole (Pyr), when measured towards 1-chloro-2,4-dinitrobenzene (CDNB) as substrate.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Rattus norvegicus	67-70
8837865-2	1996	Curcumin (0.4 g/kg body wt/day) induced a significant increase in the hepatic levels of glutathione-S-transferase (GST), acid-soluble sulfhydryl (SH), cytochrome b5, and cytochrome P-450 in lactating dams and F1 pups at 14 or 21 days.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Mus musculus	88-113
8837865-2	1996	Curcumin (0.4 g/kg body wt/day) induced a significant increase in the hepatic levels of glutathione-S-transferase (GST), acid-soluble sulfhydryl (SH), cytochrome b5, and cytochrome P-450 in lactating dams and F1 pups at 14 or 21 days.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Mus musculus	115-118
8837865-2	1996	Curcumin (0.4 g/kg body wt/day) induced a significant increase in the hepatic levels of glutathione-S-transferase (GST), acid-soluble sulfhydryl (SH), cytochrome b5, and cytochrome P-450 in lactating dams and F1 pups at 14 or 21 days.	Curcumin	0-8	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	170-186
8837865-5	1996	Curcumin-induced levels of GST and SH were depressed whereas cytochrome b5 and cytochrome P-450 were further elevated by curcumin+arecoline treatment.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Mus musculus	27-30
8837865-5	1996	Curcumin-induced levels of GST and SH were depressed whereas cytochrome b5 and cytochrome P-450 were further elevated by curcumin+arecoline treatment.	Curcumin	121-129	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	79-95
33819551-13	2021	Also, curcumin significantly reduced Iba-1 (P < 0.	Curcumin	6-14	allograft inflammatory factor 1	Rattus norvegicus	37-42
33798807-7	2021	The results suggested that curcumin remarkably inhibited the expression of NF-kappaB and pyroptosis related proteins and increased the expression of SIRT1.	Curcumin	27-35	sirtuin 1	Mus musculus	149-154
33798807-8	2021	However, EX527, a SIRT1 inhibitor, blocked the protective effect of curcumin against ALI.	Curcumin	68-76	sirtuin 1	Mus musculus	18-23
33237490-6	2021	In addition, curcumin treatment has been found to cause a significant reduction in AChE activities and MDA levels in synaptosomes (P < 0.05).	Curcumin	13-21	acetylcholinesterase	Rattus norvegicus	83-87
33237490-7	2021	Co-administration of BA and curcumin on synaptosomes exposed to Abeta1-42 resulted in a significant decrease in DNA fragmentation values, MDA levels, and AChE activities.	Curcumin	28-36	acetylcholinesterase	Rattus norvegicus	154-158
34894517-5	2022	ELISA results showed curcumin could significantly reduce the secretion of IL-17A, IL-1beta, IL -6 and TGF-beta1.	Curcumin	21-29	interleukin 17A	Rattus norvegicus	74-80
34894517-6	2022	Bioinformatics analyses revealed that the IL-17 signaling pathway are involved in the therapeutic mechanism of curcumin.	Curcumin	111-119	interleukin 17A	Rattus norvegicus	42-47
34894517-8	2022	The therapeutic effect of curcumin on AF was attributed to its effect on the IL-17 signaling pathway.	Curcumin	26-34	interleukin 17A	Rattus norvegicus	77-82
34894518-10	2022	CM supplementation (25 mg/kg) significantly decreased serum p53, TNF-alpha, CRP and IL-6 compared with MF.	Curcumin	0-2	transformation related protein 53, pseudogene	Mus musculus	60-63
34958454-0	2022	Curcumin Synergizes with Cisplatin to Inhibit Colon Cancer through Targeting the MicroRNA-137-Glutaminase Axis.	Curcumin	0-8	glutaminase	Homo sapiens	94-105
34958454-10	2022	Cell responses to curcumin treatments were evaluated by MTT assay, Clonogenic assay and Annexin V apoptosis assay.	Curcumin	18-26	annexin A5	Homo sapiens	88-97
34987702-0	2021	Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen-Induced IRE1alpha/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS-Like Rats.	Curcumin	0-8	X-box binding protein 1	Rattus norvegicus	132-136
34987702-9	2021	Both curcumin gavage and aerobic exercise improved ovarian function via inhibiting the hyperandrogen-activated ER stress IRE1alpha-XBP1 pathway.	Curcumin	5-13	X-box binding protein 1	Rattus norvegicus	131-135
34939316-10	2022	Moreover, curcumin inhibited the HRV-induced expression of MMP-9, TGF-beta, collagen I and LTC4S (p < 0.05).	Curcumin	10-18	leukotriene C4 synthase	Homo sapiens	91-96
34939316-12	2022	Concluding, our study shows that curcumin significantly downregulated gene expression related to the remodelling process, which is dependent on NF-kappaB and, partially, on c-Myc and STAT3.	Curcumin	33-41	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	173-178
34357837-9	2021	In vitro, curcumin attenuated cell proliferation, suppressed the expression of vimentin and TLR4, and increased the expression of E-cadherin and BAMBI in BPH-1 cells.	Curcumin	10-18	vimentin	Homo sapiens	79-87
34357837-9	2021	In vitro, curcumin attenuated cell proliferation, suppressed the expression of vimentin and TLR4, and increased the expression of E-cadherin and BAMBI in BPH-1 cells.	Curcumin	10-18	toll like receptor 4	Homo sapiens	92-96
34357837-10	2021	Furthermore, BAMBI knockdown reversed the expression of vimentin and E-cadherin induced by curcumin.	Curcumin	91-99	vimentin	Homo sapiens	56-64
34357837-12	2021	Furthermore, curcumin suppressed EMT by targeting BAMBI via the TLR4/BAMBI/TGF-beta1 signalling pathway in vitro, demonstrating its potential utility in BPH treatment.	Curcumin	13-21	toll like receptor 4	Homo sapiens	64-68
34161872-2	2021	Experimentally, curcumin was dissolved and deprotonated in sodium caseinate-laponite  (NaCas-LAP) dispersion at pH 12.0 for 30 min followed by neutralization to pH = 7.	Curcumin	16-24	LAP	Homo sapiens	93-96
34161872-3	2021	Due to the pH-mediated dissociation and re-association process, curcumin was successfully encapsulated into NaCas-LAP nanocomposites.	Curcumin	64-72	LAP	Homo sapiens	114-117
34161872-5	2021	The results indicated that upon neutralization, NaCas-LAP nanocomposites were re-associated into smaller particles due to strong hydrophobic interactions among NaCas, LAP and curcumin.	Curcumin	175-183	LAP	Homo sapiens	54-57
34161872-6	2021	Specifically, 0.10% curcumin loaded nanocomposites prepared with 2% NaCas and 0.5% LAP showed improved encapsulation performance (73.4%) with smaller particle size (100 nm).	Curcumin	20-28	LAP	Homo sapiens	83-86
34496087-0	2021	The effect of nanomicelle curcumin supplementation and Nigella sativa oil on the expression level of miRNA-21, miRNA-422a, and miRNA-503 gene in postmenopausal women with low bone mass density: A randomized, triple-blind, placebo-controlled clinical trial with factorial design.	Curcumin	26-34	microRNA 21	Homo sapiens	101-109
34235754-0	2021	Immunomodulatory effects of phytosomal curcumin on related-micro RNAs, CD200 expression and inflammatory pathways in dental pulp stem cells.	Curcumin	39-47	CD200 molecule	Homo sapiens	71-76
34374130-4	2021	In the current study, we demonstrate that curcumin can enhance 5-Fu chemosensitivity in HCC cells in vitro, increase the apoptosis rate, arrest the cell cycle at G2/M phase, and block the PI3k/AKT/mTOR signalling pathway by inhibiting the phosphorylation of PI3K and its downstream protein kinases.	Curcumin	42-50	mechanistic target of rapamycin kinase	Mus musculus	197-201
34577642-0	2021	The Synthetic Curcumin Analog HO-3867 Rescues Suppression of PLAC1 Expression in Ovarian Cancer Cells.	Curcumin	14-22	placenta enriched 1	Homo sapiens	61-66
34153850-6	2021	In addition, curcumin pretreatment significantly increased the expression of nuclear Nrf2, and the productions of superoxide dismutase 1 and heme oxygenase-1, which were the target anti-oxidative enzymes of the Keap1/Nrf2/ARE pathway.	Curcumin	13-21	heme oxygenase 1	Homo sapiens	141-157
34147836-0	2021	Influence of curcumin and rosmarinic acid on disrupting the general properties of Alpha-Synuclein oligomer: Molecular dynamics simulation.	Curcumin	13-21	synuclein alpha	Homo sapiens	82-97
34448459-0	2021	Curcumin attenuates renal ischemia reperfusion injury via JNK pathway with the involvement of p300/CBP-mediated histone acetylation.	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	58-61
34448459-9	2021	In addition, SP600125 suppressed the binding level of p300/CBP and H3K9 acetylation near the promoter region of caspase-3/-9, and curcumin could inhibit JNK phosphorylation like SP600125.	Curcumin	130-138	mitogen-activated protein kinase 8	Rattus norvegicus	153-156
34448459-10	2021	These results indicate that curcumin could attenuate renal IRI via JNK/p300/CBP-mediated anti-apoptosis signaling.	Curcumin	28-36	mitogen-activated protein kinase 8	Rattus norvegicus	67-70
34440609-4	2021	In the present study, after screening a series of curcumin derivatives synthesized in our laboratory, (E)-3-((E)-4-chlorobenzylidene)-5-((5-methoxy-1H-indol-3-yl)methylene)-1-methylpiperidin-4-one (CB-2) was selected as a candidate for further study.	Curcumin	50-58	cannabinoid receptor 2	Homo sapiens	198-202
34443680-0	2021	Interaction between Curcumin and beta-Casein: Multi-Spectroscopic and Molecular Dynamics Simulation Methods.	Curcumin	20-28	casein beta	Homo sapiens	33-44
34443680-1	2021	Effect of temperature and pH on the interaction of curcumin with beta-casein was explored by fluorescence spectroscopy, ultraviolet-visible spectroscopy and molecular dynamics simulation.	Curcumin	51-59	casein beta	Homo sapiens	65-76
34443680-2	2021	The spectroscopic results showed that curcumin could bind to beta-casein to form a complex which was driven mainly by electrostatic interaction.	Curcumin	38-46	casein beta	Homo sapiens	61-72
34443680-3	2021	The intrinsic fluorescence of beta-casein was quenched by curcumin through static quenching mechanism.	Curcumin	58-66	casein beta	Homo sapiens	30-41
34443680-4	2021	The binding constants of curcumin to beta-casein were 6.48 x 104 L/mol (298 K), 6.17 x 104 L/mol (305 K) and 5.73 x 104 L/mol (312 K) at pH 2.0, which was greater than that (3.98 x 104 L/mol at 298 K, 3.90 x 104 L/mol at 305 K and 3.41 x 104 L/mol at 312 K) at pH 7.4.	Curcumin	25-33	casein beta	Homo sapiens	37-48
34443680-5	2021	Molecular docking study showed that binding energy of beta-casein-curcumin complex at pH 2.0 (-7.53 kcal/mol) was lower than that at pH 7.4 (-7.01 kcal/mol).	Curcumin	66-74	casein beta	Homo sapiens	54-65
34443680-6	2021	The molecular dynamics simulation study showed that the binding energy (-131.07 kJ/mol) of beta-casein-curcumin complex was relatively low at pH 2.0 and 298 K. alpha-Helix content in beta-casein was decreased and random coil content was increased in the presence of curcumin.	Curcumin	103-111	casein beta	Homo sapiens	91-102
34443680-6	2021	The molecular dynamics simulation study showed that the binding energy (-131.07 kJ/mol) of beta-casein-curcumin complex was relatively low at pH 2.0 and 298 K. alpha-Helix content in beta-casein was decreased and random coil content was increased in the presence of curcumin.	Curcumin	103-111	casein beta	Homo sapiens	183-194
34443680-6	2021	The molecular dynamics simulation study showed that the binding energy (-131.07 kJ/mol) of beta-casein-curcumin complex was relatively low at pH 2.0 and 298 K. alpha-Helix content in beta-casein was decreased and random coil content was increased in the presence of curcumin.	Curcumin	266-274	casein beta	Homo sapiens	91-102
34443680-6	2021	The molecular dynamics simulation study showed that the binding energy (-131.07 kJ/mol) of beta-casein-curcumin complex was relatively low at pH 2.0 and 298 K. alpha-Helix content in beta-casein was decreased and random coil content was increased in the presence of curcumin.	Curcumin	266-274	casein beta	Homo sapiens	183-194
34443680-7	2021	These results can promote a deep understanding of interaction between curcumin and beta-casein and provide a reference for improving the bioavailability of curcumin.	Curcumin	70-78	casein beta	Homo sapiens	83-94
34443680-7	2021	These results can promote a deep understanding of interaction between curcumin and beta-casein and provide a reference for improving the bioavailability of curcumin.	Curcumin	156-164	casein beta	Homo sapiens	83-94
34456629-0	2021	Curcumin Antagonizes Glucose Fluctuation-Induced Renal Injury by Inhibiting Aerobic Glycolysis via the miR-489/LDHA Pathway.	Curcumin	0-8	microRNA 489	Homo sapiens	103-110
34458861-5	2021	The reduced fat accumulation by curcumin was dependent on lipogenesis-associated genes, sbp-1 (encodes the homolog of sterol response element binding proteins) and fat-6 (encodes a homolog of stearoyl-CoA desaturase), as curcumin significantly down-regulated the expression levels of these two genes and its fat reduction effect was nulled by the mutation of sbp-1 and fat-6.	Curcumin	32-40	Delta(9)-fatty-acid desaturase fat-6	Caenorhabditis elegans	164-169
34458861-5	2021	The reduced fat accumulation by curcumin was dependent on lipogenesis-associated genes, sbp-1 (encodes the homolog of sterol response element binding proteins) and fat-6 (encodes a homolog of stearoyl-CoA desaturase), as curcumin significantly down-regulated the expression levels of these two genes and its fat reduction effect was nulled by the mutation of sbp-1 and fat-6.	Curcumin	32-40	Delta(9)-fatty-acid desaturase fat-6	Caenorhabditis elegans	369-374
34458861-5	2021	The reduced fat accumulation by curcumin was dependent on lipogenesis-associated genes, sbp-1 (encodes the homolog of sterol response element binding proteins) and fat-6 (encodes a homolog of stearoyl-CoA desaturase), as curcumin significantly down-regulated the expression levels of these two genes and its fat reduction effect was nulled by the mutation of sbp-1 and fat-6.	Curcumin	221-229	Delta(9)-fatty-acid desaturase fat-6	Caenorhabditis elegans	164-169
34458861-5	2021	The reduced fat accumulation by curcumin was dependent on lipogenesis-associated genes, sbp-1 (encodes the homolog of sterol response element binding proteins) and fat-6 (encodes a homolog of stearoyl-CoA desaturase), as curcumin significantly down-regulated the expression levels of these two genes and its fat reduction effect was nulled by the mutation of sbp-1 and fat-6.	Curcumin	221-229	Delta(9)-fatty-acid desaturase fat-6	Caenorhabditis elegans	369-374
34458861-7	2021	Current results suggest that curcumin decreases fat accumulation by inhibiting sbp-1/fat-6-mediated signaling in Caenorhabditis elegans.	Curcumin	29-37	Delta(9)-fatty-acid desaturase fat-6	Caenorhabditis elegans	85-90
34323067-0	2021	Regulation on Citrate Influx and Metabolism through Inhibiting SLC13A5 and ACLY: A Novel Mechanism Mediating the Therapeutic Effects of Curcumin on NAFLD.	Curcumin	136-144	solute carrier family 13 member 5	Homo sapiens	63-70
16678799-5	2006	Curcumin, a polyphenol found in the plant Curcuma longa, has been shown to suppress the activation of NF-kappaB induced by various pro-inflammatory stimuli by inhibiting IKKbeta kinase activity in MyD88-dependent pathway.	Curcumin	0-8	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	170-177
16804969-8	2006	RESULTS: Curcumin improved survival rate and histological image, decreased the macroscopic scores and MPO activity.	Curcumin	9-17	myeloperoxidase	Rattus norvegicus	102-105
16685393-3	2006	While IFN-alpha or COX-2 inhibitors alone did not result in growth inhibition of A549 cells, the combination of IFN-alpha and celecoxib or curcumin resulted in a significant growth inhibition of A549 cells, which was associated with down-regulation of CDK2, 4, and 6 and up-regulation of p27.	Curcumin	139-147	interferon alpha inducible protein 27	Homo sapiens	288-291
16804017-6	2006	Furthermore, the preincubation of human keratinocytes at 43 degrees C for 1 h, followed by 24-h treatment with 3 microM curcumin, led to an increase in heat-shock protein (hsp70 and hsp90) levels by 24% and 19%, respectively, and the effect was sustained at concentrations up to 10 microM.	Curcumin	120-128	heat shock protein 90 alpha family class A member 1	Homo sapiens	182-187
16804017-7	2006	On the other hand, the level of the small hsp27 was unaffected by curcumin concentrations of 0.3-1 microM, while it decreased by 34% at 10 microM.	Curcumin	66-74	heat shock protein family B (small) member 1	Homo sapiens	42-47
16424149-0	2006	Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network.	Curcumin	82-90	keratin 18	Homo sapiens	111-121
16424149-5	2006	Here, we hypothesized that curcumin could restore a functional DeltaF508-CFTR to the plasma membrane acting via the K18 network.	Curcumin	27-35	keratin 18	Homo sapiens	116-119
16424149-8	2006	The K18 network then was analyzed by immunocytochemistry and immunoblot exclusively in curcumin-treated or untreated CFPAC-1 cells because of their endogenic DeltaF508-CFTR expression.	Curcumin	87-95	keratin 18	Homo sapiens	4-7
16424149-9	2006	After curcumin treatment, we observed a remodeling of the K18 network and a significant increase in K18 Ser52 phosphorylation, a site directly implicated in the reorganization of intermediate filaments.	Curcumin	6-14	keratin 18	Homo sapiens	58-61
16424149-9	2006	After curcumin treatment, we observed a remodeling of the K18 network and a significant increase in K18 Ser52 phosphorylation, a site directly implicated in the reorganization of intermediate filaments.	Curcumin	6-14	keratin 18	Homo sapiens	100-103
16770732-2	2006	The present study was undertaken to evaluate the possible antioxidant neuroprotective effect of curcumin (Cur) on neuronal death of hippocampal CA1 neurons following transient forebrain ischemia in rat.	Curcumin	96-104	carbonic anhydrase 1	Rattus norvegicus	144-147
16630125-8	2006	Curcumin reduced the expression of cell cycle regulators, cyclin D1 and c-Myc proteins, which are both degraded by activated GSK-3beta.	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	72-77
16294327-8	2006	Curcumin inhibited platelet-derived growth factor (PDGF)-induced proliferation, alpha-smooth muscle actin gene expression, interleukin-1beta- and tumor necrosis factor (TNF)-alpha-induced MCP-1 production, type I collagen production, and expression of type I and type III collagen genes.	Curcumin	0-8	C-C motif chemokine ligand 2	Rattus norvegicus	188-193
16294327-10	2006	Curcumin inhibited interleukin-1beta- and TNF-alpha-induced activation of activator protein-1 (AP-1) and mitogen-activated protein (MAP) kinases (ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase), but not of nuclear factor-kappaB (NF-kappaB).	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	151-174
16294327-10	2006	Curcumin inhibited interleukin-1beta- and TNF-alpha-induced activation of activator protein-1 (AP-1) and mitogen-activated protein (MAP) kinases (ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase), but not of nuclear factor-kappaB (NF-kappaB).	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	176-179
16648563-8	2006	Instead, molecular modeling indicates that the inhibitory effect of curcumin on DFF40/CAD activity results from curcumin binding to the active center of DFF40/CAD endonuclease.	Curcumin	68-76	aconitate decarboxylase 1	Homo sapiens	86-89
16648563-8	2006	Instead, molecular modeling indicates that the inhibitory effect of curcumin on DFF40/CAD activity results from curcumin binding to the active center of DFF40/CAD endonuclease.	Curcumin	68-76	aconitate decarboxylase 1	Homo sapiens	159-162
16648563-8	2006	Instead, molecular modeling indicates that the inhibitory effect of curcumin on DFF40/CAD activity results from curcumin binding to the active center of DFF40/CAD endonuclease.	Curcumin	112-120	aconitate decarboxylase 1	Homo sapiens	86-89
16648563-8	2006	Instead, molecular modeling indicates that the inhibitory effect of curcumin on DFF40/CAD activity results from curcumin binding to the active center of DFF40/CAD endonuclease.	Curcumin	112-120	aconitate decarboxylase 1	Homo sapiens	159-162
16106398-5	2006	Curcumin induced cell cycle arrest by reducing the expression of cyclin D1, Cdk1 and Cdc25C and apoptosis by reducing the expression of XIAP and survivin.	Curcumin	0-8	cyclin dependent kinase 1	Homo sapiens	76-80
16106398-5	2006	Curcumin induced cell cycle arrest by reducing the expression of cyclin D1, Cdk1 and Cdc25C and apoptosis by reducing the expression of XIAP and survivin.	Curcumin	0-8	cell division cycle 25C	Homo sapiens	85-91
16423986-0	2006	Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice.	Curcumin	31-39	chromobox 8	Homo sapiens	92-96
16170359-0	2006	Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1.	Curcumin	0-8	early growth response 1	Homo sapiens	174-179
16170359-7	2006	Promoter deletion assays and site-directed mutageneses identified a binding site for the transcription factor early growth response-1 (Egr-1) in egfr promoter as a putative curcumin response element in regulating the promoter activity of the gene in Moser cells.	Curcumin	173-181	early growth response 1	Homo sapiens	110-133
16170359-7	2006	Promoter deletion assays and site-directed mutageneses identified a binding site for the transcription factor early growth response-1 (Egr-1) in egfr promoter as a putative curcumin response element in regulating the promoter activity of the gene in Moser cells.	Curcumin	173-181	early growth response 1	Homo sapiens	135-140
16170359-8	2006	Electrophoretic mobility shift assays demonstrated that curcumin significantly reduced the DNA-binding activity of the transcription factor Egr-1 to the curcumin response element.	Curcumin	56-64	early growth response 1	Homo sapiens	140-145
16170359-8	2006	Electrophoretic mobility shift assays demonstrated that curcumin significantly reduced the DNA-binding activity of the transcription factor Egr-1 to the curcumin response element.	Curcumin	153-161	early growth response 1	Homo sapiens	140-145
16170359-9	2006	In addition, curcumin reduced the trans-activation activity of Egr-1 by suppressing egr-1 gene expression, which required interruption of the ERK signal pathway and reduction of the level of phosphorylation of Elk-1 and its activity.	Curcumin	13-21	early growth response 1	Homo sapiens	63-68
16170359-9	2006	In addition, curcumin reduced the trans-activation activity of Egr-1 by suppressing egr-1 gene expression, which required interruption of the ERK signal pathway and reduction of the level of phosphorylation of Elk-1 and its activity.	Curcumin	13-21	early growth response 1	Homo sapiens	84-89
16170359-10	2006	Taken together, our results demonstrated that curcumin inhibited human colon cancer cell growth by suppressing gene expression of EGFR through reducing the trans-activation activity of Egr-1.	Curcumin	46-54	early growth response 1	Homo sapiens	185-190
17357487-13	2006	This beneficial effect of curcumin may involves, in part, inhibition of neutrophilic recruitment and activity, possibly through inhibition of lung CINC-1 expression.	Curcumin	26-34	C-X-C motif chemokine ligand 1	Rattus norvegicus	147-153
15987718-0	2005	Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5).	Curcumin	0-8	TNF receptor superfamily member 10b	Homo sapiens	177-180
15987718-5	2005	We found that treatment with curcumin significantly induces death receptor 5 (DR5) expression both at its mRNA and protein levels, accompanying the generation of the reactive oxygen species (ROS).	Curcumin	29-37	TNF receptor superfamily member 10b	Homo sapiens	60-76
15987718-5	2005	We found that treatment with curcumin significantly induces death receptor 5 (DR5) expression both at its mRNA and protein levels, accompanying the generation of the reactive oxygen species (ROS).	Curcumin	29-37	TNF receptor superfamily member 10b	Homo sapiens	78-81
15987718-6	2005	Not only the pretreatment with N-acetylcystine but also the ectopic expression of peroxiredoxin II, an antioxidative protein, dramatically inhibited the apoptosis induced by curcumin and TRAIL in combination, blocking the curcumin-mediated DR5 upregulation.	Curcumin	174-182	TNF receptor superfamily member 10b	Homo sapiens	240-243
15987718-7	2005	Taken together, the present study demonstrates that curcumin enhances TRAIL-induced apoptosis by ROS-mediated DR5 upregulation.	Curcumin	52-60	TNF receptor superfamily member 10b	Homo sapiens	110-113
16081677-0	2005	Curcumin suppresses interleukin 1beta-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways.	Curcumin	0-8	early growth response 1	Homo sapiens	97-125
16081677-4	2005	Interleukin-1beta-induced microsomal prostaglandin E synthase 1 (mPGES-1) and cyclooxygenase-2 were attenuated by curcumin at the protein and mRNA levels, but a more dramatic inhibition of mPGES-1 expression was observed at lower concentrations of curcumin in A549 human lung epithelial cells.	Curcumin	114-122	prostaglandin E synthase	Mus musculus	65-72
16081677-4	2005	Interleukin-1beta-induced microsomal prostaglandin E synthase 1 (mPGES-1) and cyclooxygenase-2 were attenuated by curcumin at the protein and mRNA levels, but a more dramatic inhibition of mPGES-1 expression was observed at lower concentrations of curcumin in A549 human lung epithelial cells.	Curcumin	114-122	prostaglandin E synthase	Mus musculus	189-196
16081677-4	2005	Interleukin-1beta-induced microsomal prostaglandin E synthase 1 (mPGES-1) and cyclooxygenase-2 were attenuated by curcumin at the protein and mRNA levels, but a more dramatic inhibition of mPGES-1 expression was observed at lower concentrations of curcumin in A549 human lung epithelial cells.	Curcumin	248-256	prostaglandin E synthase	Mus musculus	65-72
16081677-5	2005	The inhibition of mPGES-1 expression by curcumin shifted the arachidonic acid profile from PGE(2) to PGF(2alpha) and 6-keto-PGF(1alpha) as major metabolites.	Curcumin	40-48	prostaglandin E synthase	Mus musculus	18-25
16081677-6	2005	The expression of early growth response gene 1 (EGR-1), a key transcription factor of cytokine-induced mPGES-1, was inhibited by curcumin.	Curcumin	129-137	early growth response 1	Homo sapiens	18-46
16081677-6	2005	The expression of early growth response gene 1 (EGR-1), a key transcription factor of cytokine-induced mPGES-1, was inhibited by curcumin.	Curcumin	129-137	early growth response 1	Homo sapiens	48-53
16081677-6	2005	The expression of early growth response gene 1 (EGR-1), a key transcription factor of cytokine-induced mPGES-1, was inhibited by curcumin.	Curcumin	129-137	prostaglandin E synthase	Mus musculus	103-110
16081677-9	2005	Curcumin inhibited IkappaBalpha phosphorylation and degradation and thus reduced the expression of mPGES-1.	Curcumin	0-8	prostaglandin E synthase	Mus musculus	99-106
16081677-10	2005	Curcumin suppressed cytokine-induced mPGES-1 by inhibiting phosphorylation of Jun N-terminal kinase (JNK)1/2.	Curcumin	0-8	prostaglandin E synthase	Mus musculus	37-44
16081677-11	2005	However, EGR-1 expression was suppressed by lower concentrations of curcumin, as compared with JNK1/2 and IkappaBalpha.	Curcumin	68-76	early growth response 1	Homo sapiens	9-14
16081677-12	2005	These results indicate that curcumin inhibits IL-1beta-induced PGE(2) formation by inhibiting the expression of mPGES-1 that is mediated by suppression of EGR-1 expression as well as NF-kappaB and JNK1/2.	Curcumin	28-36	prostaglandin E synthase	Mus musculus	112-119
16081677-12	2005	These results indicate that curcumin inhibits IL-1beta-induced PGE(2) formation by inhibiting the expression of mPGES-1 that is mediated by suppression of EGR-1 expression as well as NF-kappaB and JNK1/2.	Curcumin	28-36	early growth response 1	Homo sapiens	155-160
16129047-0	2005	[Effect of curcumin on caspase 8- and caspase 9- induced apoptosis of lymphoma Raji cell].	Curcumin	11-19	caspase 9	Homo sapiens	38-47
16129047-6	2005	The expressions of caspase 8 and caspase 9 in Raji cells after treatment with curcumin at 25 micromol/L (IC(50)) and for 24 hours were detected by Western blot.	Curcumin	78-86	caspase 9	Homo sapiens	33-42
16129047-10	2005	It is concluded that the expression of caspase 8 and caspase 9 plays an important role in the proliferation and apoptosis of Raji cells, so that curcumin showed inhibitive effect on Raji cells at various concentrations.	Curcumin	145-153	caspase 9	Homo sapiens	53-62
15879598-0	2005	Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity.	Curcumin	50-58	peroxiredoxin 5	Homo sapiens	0-21
15879598-11	2005	Inhibition of TrxR by curcumin added to cultured HeLa cells was also observed with an IC(50) of around 15 microM.	Curcumin	22-30	peroxiredoxin 5	Homo sapiens	14-18
15879598-12	2005	Modification of TrxR by curcumin provides a possible mechanistic explanation for its cancer preventive activity, shifting the enzyme from an antioxidant to a prooxidant.	Curcumin	24-32	peroxiredoxin 5	Homo sapiens	16-20
15885658-6	2005	Curcumin inhibited MRP1 transport only in the vesicle model pointing at inhibition by the parent compound.	Curcumin	0-8	ATP binding cassette subfamily C member 1	Canis lupus familiaris	19-23
15885658-7	2005	The glutathione conjugates of curcumin also inhibit MRP1 mediated transport, but to a much lesser extent than the parent compound curcumin.	Curcumin	30-38	ATP binding cassette subfamily C member 1	Canis lupus familiaris	52-56
15911101-3	2005	Curcumin exerted cell growth inhibitory and apoptotic effects, related, at least part, to free radical generation and mainly dependent on caspase-9 and -3 activation.	Curcumin	0-8	caspase 9	Homo sapiens	138-154
15911101-7	2005	Curcumin determined early changes in COX-2 and c-myc mRNAs, which were down-regulated, and in livin mRNA, which was up-regulated.	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	47-52
15911101-10	2005	The cytotoxic interactions between curcumin and these agents were accompanied by synergistic (in particular with cisplatin) or additive effects of decrease in the expression of different genes, including c-myc, Bcl-X(L), c-IAP-2, NAIP and XIAP.	Curcumin	35-43	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	204-209
15911101-10	2005	The cytotoxic interactions between curcumin and these agents were accompanied by synergistic (in particular with cisplatin) or additive effects of decrease in the expression of different genes, including c-myc, Bcl-X(L), c-IAP-2, NAIP and XIAP.	Curcumin	35-43	baculoviral IAP repeat containing 3	Homo sapiens	221-228
15911101-10	2005	The cytotoxic interactions between curcumin and these agents were accompanied by synergistic (in particular with cisplatin) or additive effects of decrease in the expression of different genes, including c-myc, Bcl-X(L), c-IAP-2, NAIP and XIAP.	Curcumin	35-43	NLR family apoptosis inhibitory protein	Homo sapiens	230-234
15923610-3	2005	The functional significance of a putative ARE in the GI-GPx promoter was validated by transcriptional activation of reporter gene constructs upon exposure to electrophiles (tBHQ, SFN, and curcumin) or overexpression of Nrf2 and by reversal of these effects by mutation of the ARE in the promoter and by overexpressed Keap1.	Curcumin	188-196	glutathione peroxidase 2	Homo sapiens	53-59
15923610-5	2005	Thus, the presumed natural antioxidants sulforaphane and curcumin may exert their anti-inflammatory and anticarcinogenic effects not only by induction of phase 2 enzymes but also by the up-regulation of the selenoprotein GI-GPx.	Curcumin	57-65	glutathione peroxidase 2	Homo sapiens	221-227
16013440-0	2005	Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-kB and caspase activated DNase.	Curcumin	59-67	DNA fragmentation factor, beta subunit	Mus musculus	93-116
16013440-4	2005	Further, we demonstrate that the induction of apoptosis in EAT cells showed nuclear condensation, DNA fragmentation and translocation of caspase-activated DNase (CAD) to nucleus upon curcumin treatment.	Curcumin	183-191	DNA fragmentation factor, beta subunit	Mus musculus	137-160
16013440-4	2005	Further, we demonstrate that the induction of apoptosis in EAT cells showed nuclear condensation, DNA fragmentation and translocation of caspase-activated DNase (CAD) to nucleus upon curcumin treatment.	Curcumin	183-191	DNA fragmentation factor, beta subunit	Mus musculus	162-165
16013440-8	2005	However, immunoflurescence studies of NF-kB revealed that the inhibition of nuclear translocation of NF-kB p65, a transcription factor required for VEGF gene expression, in curcumin-treated EAT cells.	Curcumin	173-181	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	107-110
15661804-5	2005	In Bax-/- cells curcumin-induced activation of caspases 9 and 3 was blocked and that of caspase 8 remained unaltered.	Curcumin	16-24	caspase 9	Homo sapiens	47-63
15661804-6	2005	Curcumin-induced release of cytochrome c, Second mitochondria derived activator of caspase (Smac) and apoptosis inducing factor (AIF) was also blocked in Bax-/- cells and reintroduction of Bax, downregulation of the antiapoptotic protein Bcl-XL by antisense DNA as well as the overexpression of Smac, highly sensitized the Bax-/- cells toward curcumin-induced apoptosis.	Curcumin	0-8	diablo IAP-binding mitochondrial protein	Homo sapiens	42-90
15661804-6	2005	Curcumin-induced release of cytochrome c, Second mitochondria derived activator of caspase (Smac) and apoptosis inducing factor (AIF) was also blocked in Bax-/- cells and reintroduction of Bax, downregulation of the antiapoptotic protein Bcl-XL by antisense DNA as well as the overexpression of Smac, highly sensitized the Bax-/- cells toward curcumin-induced apoptosis.	Curcumin	0-8	diablo IAP-binding mitochondrial protein	Homo sapiens	92-96
15661804-6	2005	Curcumin-induced release of cytochrome c, Second mitochondria derived activator of caspase (Smac) and apoptosis inducing factor (AIF) was also blocked in Bax-/- cells and reintroduction of Bax, downregulation of the antiapoptotic protein Bcl-XL by antisense DNA as well as the overexpression of Smac, highly sensitized the Bax-/- cells toward curcumin-induced apoptosis.	Curcumin	0-8	diablo IAP-binding mitochondrial protein	Homo sapiens	295-299
15661804-6	2005	Curcumin-induced release of cytochrome c, Second mitochondria derived activator of caspase (Smac) and apoptosis inducing factor (AIF) was also blocked in Bax-/- cells and reintroduction of Bax, downregulation of the antiapoptotic protein Bcl-XL by antisense DNA as well as the overexpression of Smac, highly sensitized the Bax-/- cells toward curcumin-induced apoptosis.	Curcumin	343-351	diablo IAP-binding mitochondrial protein	Homo sapiens	92-96
15661804-8	2005	The present study demonstrates the role of Bax but not Bak as a critical regulator of curcumin-induced apoptosis and implies the potential of targeting antiapoptotic proteins like Bcl-XL or overexpression of proapoptotic proteins like Smac as interventional approaches to deal with Bax-deficient chemo-resistant cancers for curcumin-based therapy.	Curcumin	86-94	diablo IAP-binding mitochondrial protein	Homo sapiens	235-239
15514944-11	2005	Most interestingly, curcumin can reverse the expression dynamics of c-fos and fra-1 in this tumorigenic cell line, mimicking the expression pattern observed in normal controls or precancerous lesions.	Curcumin	20-28	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	78-83
15514944-12	2005	Observation of curcumin-mediated complete downregulation of AP-1 binding activity and reversal of c-fos/fra-1 transcription to a normal state in tumorigenic HeLa cells represents a novel mechanism that can control transcription of pathogenic HPVs during keratinocyte differentiation and progression of cervical cancer.	Curcumin	15-23	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	104-109
15590663-6	2005	Under EM, curcumin decreased dose dependently Abeta fibril formation beginning with 0.125 microM.	Curcumin	10-18	amyloid beta (A4) precursor protein	Mus musculus	46-51
15590663-12	2005	These data suggest that low dose curcumin effectively disaggregates Abeta as well as prevents fibril and oligomer formation, supporting the rationale for curcumin use in clinical trials preventing or treating AD.	Curcumin	33-41	amyloid beta (A4) precursor protein	Mus musculus	68-73
34323067-7	2021	In OPA-stimulated HepG2 cells, curcumin rectified the dysregulated expression of SLC13A5/ACLY possibly via the AMPK-mTOR signaling pathway.	Curcumin	31-39	solute carrier family 13 member 5	Homo sapiens	81-88
34323067-8	2021	Besides, curcumin also functionally inhibited both citrate transport and metabolism mediated by SLC13A5 and ACLY, respectively.	Curcumin	9-17	solute carrier family 13 member 5	Homo sapiens	96-103
34393686-0	2021	Nano-Curcumin Protects Against Sodium Nitrite-Induced Lung Hypoxia Through Modulation of Mitogen-Activated Protein Kinases/c-Jun NH2-Terminal Kinase Signaling Pathway.	Curcumin	5-13	mitogen-activated protein kinase 8	Rattus norvegicus	123-148
34355287-5	2021	METHODS: The effect of curcumin and BDMC-A on transcription factors (NF-kappaB, p65, c-Jun, c-Fos, STAT3, 5, PPAR-gamma, beta-catenin, COX-2, MMP-9, VEGF, TIMP-2) involved in signal transduction cascade, invasion, and angiogenesis in Hep-2 cells were quantified using Western blotting and RT-PCR technique.	Curcumin	23-31	catenin beta 1	Homo sapiens	121-133
34350255-0	2021	Curcumin exerts a protective effect on murine knee chondrocytes treated with IL-1beta through blocking the NF-kappaB/HIF-2alpha signaling pathway.	Curcumin	0-8	interleukin 1 alpha	Mus musculus	77-85
34134960-0	2021	(Curcumin induces human lens epithelial cell apoptosis and cell cycle arrest by inhibiting Wnt/beta-catenin signaling pathway).	Curcumin	1-9	catenin beta 1	Homo sapiens	95-107
34134960-6	2021	The results of Western blotting showed that curcumin also concentration-dependently increased the cellular expressions of caspase-3, caspase-9 and Bax and lowered the expressions of Bcl-2, cyclin B1, CDK1 and beta-catenin along with the downstream proteins cyclin D1 and c-myc in the Wnt/beta-catenin signaling pathway (P < 0.05).	Curcumin	44-52	caspase 9	Homo sapiens	133-142
34134960-6	2021	The results of Western blotting showed that curcumin also concentration-dependently increased the cellular expressions of caspase-3, caspase-9 and Bax and lowered the expressions of Bcl-2, cyclin B1, CDK1 and beta-catenin along with the downstream proteins cyclin D1 and c-myc in the Wnt/beta-catenin signaling pathway (P < 0.05).	Curcumin	44-52	cyclin B1	Homo sapiens	189-198
34134960-6	2021	The results of Western blotting showed that curcumin also concentration-dependently increased the cellular expressions of caspase-3, caspase-9 and Bax and lowered the expressions of Bcl-2, cyclin B1, CDK1 and beta-catenin along with the downstream proteins cyclin D1 and c-myc in the Wnt/beta-catenin signaling pathway (P < 0.05).	Curcumin	44-52	cyclin dependent kinase 1	Homo sapiens	200-204
34134960-6	2021	The results of Western blotting showed that curcumin also concentration-dependently increased the cellular expressions of caspase-3, caspase-9 and Bax and lowered the expressions of Bcl-2, cyclin B1, CDK1 and beta-catenin along with the downstream proteins cyclin D1 and c-myc in the Wnt/beta-catenin signaling pathway (P < 0.05).	Curcumin	44-52	catenin beta 1	Homo sapiens	209-221
34134960-6	2021	The results of Western blotting showed that curcumin also concentration-dependently increased the cellular expressions of caspase-3, caspase-9 and Bax and lowered the expressions of Bcl-2, cyclin B1, CDK1 and beta-catenin along with the downstream proteins cyclin D1 and c-myc in the Wnt/beta-catenin signaling pathway (P < 0.05).	Curcumin	44-52	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	271-276
34134960-6	2021	The results of Western blotting showed that curcumin also concentration-dependently increased the cellular expressions of caspase-3, caspase-9 and Bax and lowered the expressions of Bcl-2, cyclin B1, CDK1 and beta-catenin along with the downstream proteins cyclin D1 and c-myc in the Wnt/beta-catenin signaling pathway (P < 0.05).	Curcumin	44-52	catenin beta 1	Homo sapiens	288-300
34134960-7	2021	OBJECTIVE: Curcumin inhibits the proliferation of HLEC-SRA01/04 cells possibly by inhibiting the Wnt/beta-catenin signaling pathway and causing cell cycle arrest to induce cell apoptosis.	Curcumin	11-19	catenin beta 1	Homo sapiens	101-113
34159091-5	2021	Results: The serum levels of UN, Cr, NF-kappaB, ALT, AST, amylase, CK, LDH, inflammatory factors TNF-alpha and IL-10, and markers of early diagnosis of SAKI (NGAL, CysC, KIM-1) were significantly lower in the curcumin group than those in the placebo group (P<0.05).	Curcumin	209-217	hepatitis A virus cellular receptor 1	Rattus norvegicus	170-175
34159091-6	2021	In addition, serum levels of TLR9 and its downstream molecules MyD88, IRF5, and IRF7 in the curcumin group were significantly lower than those in the placebo group (P<0.05).	Curcumin	92-100	toll-like receptor 9	Rattus norvegicus	29-33
34159091-6	2021	In addition, serum levels of TLR9 and its downstream molecules MyD88, IRF5, and IRF7 in the curcumin group were significantly lower than those in the placebo group (P<0.05).	Curcumin	92-100	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	63-68
34159091-6	2021	In addition, serum levels of TLR9 and its downstream molecules MyD88, IRF5, and IRF7 in the curcumin group were significantly lower than those in the placebo group (P<0.05).	Curcumin	92-100	interferon regulatory factor 7	Rattus norvegicus	80-84
34557761-5	2021	MD2-intrinsic fluorescence titrations, surface plasmon resonance, and competitive displacement binding assays with curcumin (MD2 probe) demonstrated that both nicotine and cotinine targeted the lipopolysaccharide (LPS; TLR4 agonist) binding pocket of MD2 with similar affinities.	Curcumin	115-123	lymphocyte antigen 96	Mus musculus	251-254
34981477-0	2021	The Role of Chemokines in Cardiovascular Diseases and the Therapeutic Effect of Curcumin on CXCL8 and CCL2 as Pathological Chemokines in Atherosclerosis.	Curcumin	80-88	C-C motif chemokine ligand 2	Homo sapiens	102-106
34331686-6	2021	Given the important role of such processes in the development of endothelium dysfunction, a role for curcumin in the prevention or treatment of this condition has been hypothesized.	Curcumin	101-109	hyaluronan synthase 1	Homo sapiens	159-162
34284543-8	2021	The western blot results showed that the phosphorylation levels of ERK, JNK, MAPK, NF-kB and Akt were up-regulated by curcumin.	Curcumin	118-126	mitogen-activated protein kinase 8	Rattus norvegicus	72-75
34284543-8	2021	The western blot results showed that the phosphorylation levels of ERK, JNK, MAPK, NF-kB and Akt were up-regulated by curcumin.	Curcumin	118-126	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	83-88
35487055-10	2022	CONCLUSIONS: The antitumor effects of combination therapy with As2O3 and Curcumin have been displayed on prostate cancer cell lines (LNCaP and PC3), which probably originates from their potential to induce apoptosis and inhibit the growth of prostate cancer cells simultaneously.	Curcumin	73-81	BTG anti-proliferation factor 2	Homo sapiens	143-146
15681801-13	2004	Curcumin directly targeted Abeta and was also effective in other models, warranting further preclinical and clinical exploration.	Curcumin	0-8	amyloid beta (A4) precursor protein	Mus musculus	27-32
15604057-5	2004	Curcumin and sulfasalazine obviously suppressed the high expression of proinflammatory cytokine interleukin (IL)-1beta mRNA and increased the low expression of IL-10 mRNA in the colonic mucosa.	Curcumin	0-8	interleukin 10	Rattus norvegicus	160-165
29899871-7	2018	The amine-functionalized and FA-conjugated curcumin-loaded, especially KCC-1 MSNs penetrated all cells organs and steadily released curcumin.	Curcumin	132-140	solute carrier family 12 member 4	Homo sapiens	71-76
15569263-4	2004	We determined whether curcumin, a natural product known to have anti-inflammatory properties, suppressed Egr-1 activation and concomitant expression of cytochemokines.	Curcumin	22-30	early growth response 1	Homo sapiens	105-110
15569263-5	2004	We show that curcumin (12.5-25 microm) suppresses the activation of Egr-1 DNA-binding activity in THP-1 monocytic cells.	Curcumin	13-21	early growth response 1	Homo sapiens	68-73
15205359-7	2004	AsBcl-XL and AsKu70 cells were more sensitive to curcumin through enhanced activation of caspases 9 and 3 and release of cytochrome c, Smac and AIF.	Curcumin	49-57	caspase 9	Homo sapiens	89-105
15205359-7	2004	AsBcl-XL and AsKu70 cells were more sensitive to curcumin through enhanced activation of caspases 9 and 3 and release of cytochrome c, Smac and AIF.	Curcumin	49-57	diablo IAP-binding mitochondrial protein	Homo sapiens	135-139
15498113-0	2004	[Effect of curcumin on STAT5 signaling pathway in primary CML cells].	Curcumin	11-19	signal transducer and activator of transcription 5A	Homo sapiens	23-28
15498113-4	2004	The expression of STAT5 mRNA in curcumin group (integral ratio of OD 1.398 +/- 0.126) was significantly decreased as compared with that in the CML cells group (P &lt;0.01).	Curcumin	32-40	signal transducer and activator of transcription 5A	Homo sapiens	18-23
15498113-6	2004	The activation of STAT5 of curcumin group (gray value 4331.750 +/- 398.035) was significantly decreased as compared with that of CML cells group (P &lt;0.01).	Curcumin	27-35	signal transducer and activator of transcription 5A	Homo sapiens	18-23
15498113-10	2004	Curcumin can inhibit the cellular proliferation and the expression of STAT5 mRNA, and down-regulate the activation of STAT5 in primary CML cells.	Curcumin	0-8	signal transducer and activator of transcription 5A	Homo sapiens	70-75
15498113-10	2004	Curcumin can inhibit the cellular proliferation and the expression of STAT5 mRNA, and down-regulate the activation of STAT5 in primary CML cells.	Curcumin	0-8	signal transducer and activator of transcription 5A	Homo sapiens	118-123
15219947-5	2004	Downregulation of FAK (which would impair integrin mediated signal transduction cascade) and reduction of MMP-2 activity could be important reasons for anti-metastatic property of curcumin.	Curcumin	180-188	PTK2 protein tyrosine kinase 2	Mus musculus	18-21
15200418-6	2004	RESULTS: When applied 30 minutes before TGF-beta, curcumin dose dependently and dramatically reduced TGF-beta-induced increases in plasminogen activator inhibitor-1 (PAI-1), TGF-beta1, fibronectin (FN) and collagen I (Col I) mRNA, and in PAI-1 and fibronectin protein.	Curcumin	50-58	fibronectin 1	Rattus norvegicus	185-196
15200418-6	2004	RESULTS: When applied 30 minutes before TGF-beta, curcumin dose dependently and dramatically reduced TGF-beta-induced increases in plasminogen activator inhibitor-1 (PAI-1), TGF-beta1, fibronectin (FN) and collagen I (Col I) mRNA, and in PAI-1 and fibronectin protein.	Curcumin	50-58	fibronectin 1	Rattus norvegicus	198-200
15200418-6	2004	RESULTS: When applied 30 minutes before TGF-beta, curcumin dose dependently and dramatically reduced TGF-beta-induced increases in plasminogen activator inhibitor-1 (PAI-1), TGF-beta1, fibronectin (FN) and collagen I (Col I) mRNA, and in PAI-1 and fibronectin protein.	Curcumin	50-58	fibronectin 1	Rattus norvegicus	248-259
15200418-7	2004	Prolonged curcumin treatment (&gt;6 h) significantly reduced TGF-beta receptor type II levels and SMAD2/3 phosphorylation in response to added TGF-beta.	Curcumin	10-18	SMAD family member 2	Rattus norvegicus	98-105
15129424-11	2004	RESULTS: Curcumin inhibited the ligand-stimulated autophosphorylation of EGF-R and CSF1-R that were crucially involved in the development of osteomimetic properties of C4-2B cells.	Curcumin	9-17	colony stimulating factor 1	Homo sapiens	83-87
15128775-4	2004	In this report, we examine the ability of curcumin (diferuloylmethane), a pigment derived from turmeric, to suppress RANKL signaling and osteoclastogenesis in RAW 264.7 cells, a murine monocytic cell line.	Curcumin	42-50	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	117-122
15128775-4	2004	In this report, we examine the ability of curcumin (diferuloylmethane), a pigment derived from turmeric, to suppress RANKL signaling and osteoclastogenesis in RAW 264.7 cells, a murine monocytic cell line.	Curcumin	52-69	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	117-122
15128775-5	2004	Treatment of these cells with RANKL activated NF-kappaB, and preexposure of the cells to curcumin completely suppressed RANKL-induced NF-kappaB activation.	Curcumin	89-97	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	30-35
15128775-5	2004	Treatment of these cells with RANKL activated NF-kappaB, and preexposure of the cells to curcumin completely suppressed RANKL-induced NF-kappaB activation.	Curcumin	89-97	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	120-125
15182583-0	2004	[Effect of curcumin on STAT5 signaling molecule in K562 cells].	Curcumin	11-19	signal transducer and activator of transcription 5A	Homo sapiens	23-28
14604899-7	2004	Ashsp70 cells released more cytochrome c, AIF and Smac from mitochondria upon curcumin treatment than control cells.	Curcumin	78-86	diablo IAP-binding mitochondrial protein	Homo sapiens	50-54
15750784-9	2004	Curcumin blocks OPN-induced MT1-MMP expression and pro-MMP-2 activation.	Curcumin	0-8	secreted phosphoprotein 1	Homo sapiens	16-19
15339499-1	2004	OBJECTIVE: To observe whether curcumin could inhibit the accumulation of the collagen IV and fibronectin in the glomeruli in nephrotoxi sera nephritis rats.	Curcumin	30-38	fibronectin 1	Rattus norvegicus	93-104
15339499-9	2004	In the nephrotoxic sera nephritis rats and curcumin treated nephrotoxic sera nephritis rats, the accumulation of collagen IV and fibronectin was increased progressively, with significant difference in the accumulation of collagen IV (P&lt;0.01) between these two groups at the same time points, while the significant difference in fibronectin accumulation (P&lt;0.05) appeared only after the 7th days.	Curcumin	43-51	fibronectin 1	Rattus norvegicus	129-140
15339499-9	2004	In the nephrotoxic sera nephritis rats and curcumin treated nephrotoxic sera nephritis rats, the accumulation of collagen IV and fibronectin was increased progressively, with significant difference in the accumulation of collagen IV (P&lt;0.01) between these two groups at the same time points, while the significant difference in fibronectin accumulation (P&lt;0.05) appeared only after the 7th days.	Curcumin	43-51	fibronectin 1	Rattus norvegicus	331-342
15339499-10	2004	CONCLUSION: Curcumin can reduce the accumulation of collagen IV and fibronectin in the glomeruli.	Curcumin	12-20	fibronectin 1	Rattus norvegicus	68-79
14723822-1	2003	UNLABELLED: Curcumin is a natural compound extracted from the spice tumeric, possessing both anti-inflammatory antioxidant, and anti-carcinogenic effect, is a potent stimulator of the stress-induced expression of heat shock protein 70 kd (HSP70).	Curcumin	12-20	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	213-237
14723822-1	2003	UNLABELLED: Curcumin is a natural compound extracted from the spice tumeric, possessing both anti-inflammatory antioxidant, and anti-carcinogenic effect, is a potent stimulator of the stress-induced expression of heat shock protein 70 kd (HSP70).	Curcumin	12-20	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	239-244
14723822-13	2003	The effect might be associated with antioxidant, inhibition of the activity of cytokines and inducing expression of HSP70 by curcumin.	Curcumin	125-133	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	116-121
14627502-8	2003	The abundance of p210bcr/abl as well as MEK-1 and c-JUN proteins were strongly down-regulated in curcumin-treated p210bcr/abl-positive K562 cells while c-JUN and MEK-1 proteins were only slightly down-regulated in p210bcr/abl-negative HL-60 cells.	Curcumin	97-105	mitogen-activated protein kinase kinase 1	Homo sapiens	40-45
14627502-8	2003	The abundance of p210bcr/abl as well as MEK-1 and c-JUN proteins were strongly down-regulated in curcumin-treated p210bcr/abl-positive K562 cells while c-JUN and MEK-1 proteins were only slightly down-regulated in p210bcr/abl-negative HL-60 cells.	Curcumin	97-105	mitogen-activated protein kinase kinase 1	Homo sapiens	162-167
14555224-3	2003	In the present study, we examined the inhibitory effect of curcumin on the expression of GSTP1-1 mRNA as well as protein, and we correlated this inhibition with the apoptotic effect of curcumin on K562 leukemia cells.	Curcumin	59-67	glutathione S-transferase pi 1	Homo sapiens	89-96
14555224-3	2003	In the present study, we examined the inhibitory effect of curcumin on the expression of GSTP1-1 mRNA as well as protein, and we correlated this inhibition with the apoptotic effect of curcumin on K562 leukemia cells.	Curcumin	185-193	glutathione S-transferase pi 1	Homo sapiens	89-96
14555224-4	2003	Curcumin efficiently inhibited the tumour necrosis factor alpha- and phorbol ester-induced binding of AP-1 and NF-kappaB transcription factors to sites located on the GSTP1-1 gene promoter.	Curcumin	0-8	glutathione S-transferase pi 1	Homo sapiens	167-174
14555224-5	2003	TNFalpha-induced GSTP1-1 promoter activity was also inhibited by curcumin as shown by reporter gene assay.	Curcumin	65-73	glutathione S-transferase pi 1	Homo sapiens	17-24
14555224-7	2003	Our results overall add a novel role for curcumin as this chemoprotective compound could contribute to induce apoptosis by its ability to inhibit the GSTP1-1 expression at the level of transcription.	Curcumin	41-49	glutathione S-transferase pi 1	Homo sapiens	150-157
14534529-4	2003	The amount of wee1 and c-Fos and the phosphorylation of cdc2 were decreased after treatment of the cells with an inhibitor of AP-1, curcumin.	Curcumin	132-140	cyclin dependent kinase 1	Homo sapiens	56-60
12844482-8	2003	Curcumin treatment attenuated TPA- stimulated NF-kappaB activation in mouse skin, which was associated with its blockade of degradation of the inhibitory protein IkappaBalpha and also of subsequent translocation of the p65 subunit to nucleus.	Curcumin	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	219-222
15015361-4	2003	RESULT: Curcumin (50 mg.kg-1, 100 mg.kg-1, 150 mg.kg-1), like biophenyldicarboxylate, were shown to significantly inhibit the increase of serum ALT, AST, NO and liver molondialdehyde (MDA) content induced by CCl4, D-Gal N, BCG + LPS.	Curcumin	8-16	glutamic pyruvic transaminase, soluble	Mus musculus	144-147
12570874-7	2003	From several lines of investigation we also report that curcumin (and, by inference, CAPE) stimulates ho-1 gene activity by promoting inactivation of the Nrf2-Keap1 complex, leading to increased Nrf2 binding to the resident ho-1 AREs.	Curcumin	56-64	heme oxygenase 1	Homo sapiens	224-228
12570874-8	2003	Moreover, using antibodies and specific inhibitors of the mitogen-activated protein kinase (MAPK) pathways, we provide data implicating p38 MAPK in curcumin-mediated ho-1 induction.	Curcumin	148-156	heme oxygenase 1	Homo sapiens	166-170
12570874-9	2003	Taken together, these results demonstrate that induction of HO-1 by curcumin and CAPE requires the activation of the Nrf2/ARE pathway.	Curcumin	68-76	heme oxygenase 1	Homo sapiens	60-64
12614893-3	2003	Relative quantification with reverse transcription real-time PCR (RT-rt-PCR) showed that low concentrations of curcumin significantly down-regulated mitogen-induced granulocyte macrophage colony stimulating factor (GM-CSF) mRNA (3- to 5-fold at 3 microM) in a dose- and time-dependent manner in both cell types.	Curcumin	111-119	colony stimulating factor 2	Homo sapiens	165-213
12614893-3	2003	Relative quantification with reverse transcription real-time PCR (RT-rt-PCR) showed that low concentrations of curcumin significantly down-regulated mitogen-induced granulocyte macrophage colony stimulating factor (GM-CSF) mRNA (3- to 5-fold at 3 microM) in a dose- and time-dependent manner in both cell types.	Curcumin	111-119	colony stimulating factor 2	Homo sapiens	215-221
12393461-8	2003	Curcumin also activated caspase-7 and caspase-9 and induced polyadenosine-5"-diphosphate-ribose polymerase (PARP) cleavage.	Curcumin	0-8	caspase 7	Homo sapiens	24-33
12393461-8	2003	Curcumin also activated caspase-7 and caspase-9 and induced polyadenosine-5"-diphosphate-ribose polymerase (PARP) cleavage.	Curcumin	0-8	caspase 9	Homo sapiens	38-47
12791505-7	2003	Similarly, a significant protection was provided by curcumin in the enzyme-deficient foci for the adenosine triphosphatase-, alkaline phosphatase-, and glucose-6-phosphatase-treated groups in comparison to the DEN-AAF-treated group.	Curcumin	52-60	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	98-173
12208119-6	2002	Intragastric administration of curcumin (80mg/kg body weight) and curcumin analog (80mg/kg body weight) to DMH-injected rats significantly reduced the number and size of tumour in the colon, lowered lipid peroxidation and enhanced the activities of GPx, GST, SOD and CAT in the liver.	Curcumin	31-39	hematopoietic prostaglandin D synthase	Rattus norvegicus	254-257
12208119-6	2002	Intragastric administration of curcumin (80mg/kg body weight) and curcumin analog (80mg/kg body weight) to DMH-injected rats significantly reduced the number and size of tumour in the colon, lowered lipid peroxidation and enhanced the activities of GPx, GST, SOD and CAT in the liver.	Curcumin	66-74	hematopoietic prostaglandin D synthase	Rattus norvegicus	254-257
12082030-0	2002	Membrane-type matrix metalloproteinases mediate curcumin-induced cell migration in non-tumorigenic colon epithelial cells differing in Apc genotype.	Curcumin	48-56	APC, WNT signaling pathway regulator	Mus musculus	135-138
12082030-13	2002	The data suggest a potential mechanism by which curcumin may induce cells heterozygous for Apc to overcome defective cell migration, a phenotype associated with cell differentiation and apoptosis.	Curcumin	48-56	APC, WNT signaling pathway regulator	Mus musculus	91-94
11854435-0	2002	Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers.	Curcumin	33-41	heme oxygenase 1	Homo sapiens	60-76
11854435-2	2002	Curcumin, a polyphenolic natural compound that possesses anti-tumor and anti-inflammatory properties, has been reported recently to induce potently HO-1 expression in vascular endothelial cells (Free Rad Biol Med 28:1303-1312, 2000).	Curcumin	0-8	heme oxygenase 1	Homo sapiens	148-152
11592943-5	2001	Surprisingly, curcumin by itself was a very potent inducer of HO-1.	Curcumin	14-22	heme oxygenase 1	Homo sapiens	62-66
11592943-7	2001	To evaluate the mechanism of curcumin-mediated induction of HO-1, confluent human renal proximal tubule cells were exposed to curcumin (1-8 microM).	Curcumin	29-37	heme oxygenase 1	Homo sapiens	60-64
11592943-9	2001	Coincubation of curcumin with actinomycin D completely blocked the upregulation of HO-1 mRNA.	Curcumin	16-24	heme oxygenase 1	Homo sapiens	83-87
11592943-10	2001	Blockade of nuclear factor-kappaB (NF-kappaB) with an IkappaBalpha phosphorylation inhibitor attenuated curcumin-mediated induction of HO-1 mRNA and protein.	Curcumin	104-112	heme oxygenase 1	Homo sapiens	135-139
11592943-11	2001	These data demonstrate that curcumin induces HO-1 mRNA and protein in renal proximal tubule cells.	Curcumin	28-36	heme oxygenase 1	Homo sapiens	45-49
11592943-12	2001	HO-1 induction by curcumin is mediated, at least in part, via transcriptional mechanisms and involves the NF-kappaB pathway.	Curcumin	18-26	heme oxygenase 1	Homo sapiens	0-4
11422736-14	2001	Curcumin, an inhibitor of AP-1, dose-dependently suppressed the induction of MCP-1 mRNA by high glucose.	Curcumin	0-8	C-C motif chemokine ligand 2	Homo sapiens	77-82
11396178-4	2001	Investigation of cyclin-dependent kinases, Cdk2 and Cdc2, showed activity of Cdc2, but not Cdk2, increased markedly in response to curcumin.	Curcumin	131-139	cyclin dependent kinase 1	Homo sapiens	52-56
11396178-4	2001	Investigation of cyclin-dependent kinases, Cdk2 and Cdc2, showed activity of Cdc2, but not Cdk2, increased markedly in response to curcumin.	Curcumin	131-139	cyclin dependent kinase 1	Homo sapiens	77-81
11207308-8	2001	Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.	Curcumin	11-19	Janus kinase 3	Homo sapiens	218-222
11207308-8	2001	Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.	Curcumin	21-38	Janus kinase 3	Homo sapiens	218-222
11207308-9	2001	Curcumin also inhibited OSM-induced MMP-1, MMP-3, MMP-13, and TIMP-3 gene expression.	Curcumin	0-8	matrix metallopeptidase 1	Homo sapiens	36-41
11231886-0	2001	Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin.	Curcumin	90-98	FBJ osteosarcoma oncogene	Mus musculus	46-51
11231886-4	2001	Topical application of curcumin was reported to inhibit TPA-induced c-fos, c-jun and c-myc gene expression in mouse skin.	Curcumin	23-31	FBJ osteosarcoma oncogene	Mus musculus	68-73
11231886-7	2001	Also, the dietary consumption of curcumin resulted in a significantly decreased expression of ras and fos proto-oncogenes in the tumorous skin, as measured by enhanced chemiluminesence Western blotting detection system (Amersham).	Curcumin	33-41	FBJ osteosarcoma oncogene	Mus musculus	102-105
11231886-8	2001	CONCLUSIONS: Whereas earlier work demonstrated that topical application of curcumin to mouse skin inhibited TPA-induced expression of c-fos, c-jun and c-myc oncogenes, our results are the first to show that orally consumed curcumin significantly inhibited DMBA- and TPA-induced ras and fos gene expression in mouse skin.	Curcumin	75-83	FBJ osteosarcoma oncogene	Mus musculus	134-139
11231886-8	2001	CONCLUSIONS: Whereas earlier work demonstrated that topical application of curcumin to mouse skin inhibited TPA-induced expression of c-fos, c-jun and c-myc oncogenes, our results are the first to show that orally consumed curcumin significantly inhibited DMBA- and TPA-induced ras and fos gene expression in mouse skin.	Curcumin	75-83	FBJ osteosarcoma oncogene	Mus musculus	136-139
10617637-10	2000	The mRNA up-regulation of MMPs was also inhibited by curcumin, an inhibitor of transcription factor AP-1, whereas interleukin-1 receptor antagonist, an IL-1 receptor antagonist, failed to inhibit the mRNA up-regulation.	Curcumin	53-61	matrix metallopeptidase 1	Homo sapiens	26-30
10965519-3	2000	Our results showed that genistein and curcumin blocked this response in a dose-dependent manner and also inhibited the TGF-beta 1-induced synthesis of fibronectin, an early responsive gene to the growth factor.	Curcumin	38-46	fibronectin 1	Mus musculus	151-162
10527691-0	1999	Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53.	Curcumin	0-8	early growth response 1	Homo sapiens	88-93
10527691-0	1999	Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53.	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	95-100
10527691-5	1999	Furthermore, curcumin downregulated the expression of survival genes egr-1, c-myc, and bcl-X(L) as well as the tumor suppressor gene p53 in B cells.	Curcumin	13-21	early growth response 1	Homo sapiens	69-74
10527691-5	1999	Furthermore, curcumin downregulated the expression of survival genes egr-1, c-myc, and bcl-X(L) as well as the tumor suppressor gene p53 in B cells.	Curcumin	13-21	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	76-81
10576620-2	1999	We demonstrate here that out of three compounds, viz diferuloylmethane, p-coumaroylferuloylmethane and di-p-coumaroylmethane, present in the ethyl acetate extract of Curcuma longa, diferuloylmethane is most potent in inhibiting TNF-alpha induced expression of ICAM-1, VCAM-1 and E-selectin on human umbilical vein endothelial cells.	Curcumin	181-198	selectin E	Homo sapiens	279-289
10557090-0	1999	Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex.	Curcumin	87-95	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	148-151
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Curcumin	0-8	C-C motif chemokine ligand 3	Homo sapiens	43-53
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Curcumin	0-8	C-C motif chemokine ligand 2	Homo sapiens	55-60
10051376-6	1999	These results show that curcumin exhibits an inhibitory effect on the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages.	Curcumin	24-32	C-C motif chemokine ligand 3	Homo sapiens	90-100
10051376-6	1999	These results show that curcumin exhibits an inhibitory effect on the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages.	Curcumin	24-32	C-C motif chemokine ligand 2	Homo sapiens	102-107
9674701-6	1998	In transfection assays, curcumin moderately suppressed MEKK1-induced JNK activation; however, it effectively blocked JNK activation caused by co-transfection of TAK1, GCK, or HPK1.	Curcumin	24-32	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	161-165
9674701-8	1998	Although curcumin suppressed TAK1 and GCK activities at high concentrations, this inhibition cannot fully account for the JNK inhibition by curcumin in vivo.	Curcumin	9-17	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	29-33
9674701-9	1998	Our data suggest that curcumin may affect the JNK pathway by interfering with the signaling molecule(s) at the same level or proximally upstream of the MAPKKK level.	Curcumin	22-30	mitogen-activated protein kinase kinase kinase 4	Homo sapiens	152-158
9586949-4	1998	Pretreatment of EC for 1 hr with curcumin completely blocked their adhesion to monocytes, as well as the cell surface expression of ICAM-1, VCAM-1, and ELAM-1 in EC.	Curcumin	33-41	selectin E	Homo sapiens	152-158
9437186-0	1997	Inhibition of tissue factor gene activation in cultured endothelial cells by curcumin.	Curcumin	77-85	coagulation factor III, tissue factor	Homo sapiens	14-27
9437186-6	1997	In the present study, we demonstrate that curcumin (diferulolylmethane), a known anticarcinogenic and anti-inflammatory agent, inhibited phorbol 12-myristate 13-acetate (PMA), LPS, TNF alpha, and thrombin-induced TF activity and TF gene transcription in human endothelial cells.	Curcumin	42-50	coagulation factor III, tissue factor	Homo sapiens	213-215
9437186-7	1997	The present data show that curcumin prevented the activation of c-Rel/p65, which is essential for TF gene activation in endothelial cells, by impairing the proteolytic degradation inhibitor protein, I kappa B alpha.	Curcumin	27-35	coagulation factor III, tissue factor	Homo sapiens	98-100
9437186-10	1997	Overall, the data suggest that the anticarcinogenic and anti-inflammatory properties of curcumin may be related to its ability to inhibit cellular gene expression regulated by transcription factors NF-kappa B, AP-1, and Egr-1.	Curcumin	88-96	early growth response 1	Homo sapiens	220-225
9353136-0	1997	Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics.	Curcumin	0-8	colony stimulating factor 2	Homo sapiens	81-129
9353136-0	1997	Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics.	Curcumin	0-8	colony stimulating factor 2	Homo sapiens	131-137
9353136-6	1997	Furthermore, curcumin inhibited IL-5, GM-CSF, and IL-4 production in a concentration-dependent manner.	Curcumin	13-21	colony stimulating factor 2	Homo sapiens	38-44
9168063-5	1997	A detailed analysis of the regulatory effects of curcumin on chemokine expression by IL-1alpha was performed.	Curcumin	49-57	interleukin 1 alpha	Mus musculus	85-94
9134658-0	1997	The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa B.	Curcumin	20-28	Jun proto-oncogene, AP-1 transcription factor subunit	Bos taurus	104-108
9134658-2	1997	It appears, that the pleiotropic effects of curcumin are at least partly due to inhibition of the transcription factors NF-kappa B and AP-1.	Curcumin	44-52	Jun proto-oncogene, AP-1 transcription factor subunit	Bos taurus	135-139
9134658-3	1997	This study investigates the effect of curcumin on the TNF alpha induced expression of endothelial Tissue Factor (TF), the central mediator of coagulation known to be controlled by AP-1 and NF-kappa B.	Curcumin	38-46	tumor necrosis factor	Bos taurus	54-63
9134658-3	1997	This study investigates the effect of curcumin on the TNF alpha induced expression of endothelial Tissue Factor (TF), the central mediator of coagulation known to be controlled by AP-1 and NF-kappa B.	Curcumin	38-46	Jun proto-oncogene, AP-1 transcription factor subunit	Bos taurus	180-184
9134658-4	1997	When bovine aortic endothelial cells (BAEC) were preincubated in the presence of curcumin, TNF alpha induced TF gene transcription and expression were reduced.	Curcumin	81-89	tumor necrosis factor	Bos taurus	91-100
9134658-5	1997	Transient transfection studies with TF-promoter plasmids revealed that both, NF-kappa B and AP-1 dependent TF expression, were reduced by curcumin action.	Curcumin	138-146	Jun proto-oncogene, AP-1 transcription factor subunit	Bos taurus	92-96
9134658-7	1997	Curcumin inhibited TNF alpha induced I kappa B alpha degradation and the nuclear import of NF-kappa B.	Curcumin	0-8	tumor necrosis factor	Bos taurus	19-28
9134658-8	1997	In contrast, inhibition of AP-1 was due to a direct interaction of curcumin with AP-1-binding to its DNA binding motif.	Curcumin	67-75	Jun proto-oncogene, AP-1 transcription factor subunit	Bos taurus	27-31
9134658-8	1997	In contrast, inhibition of AP-1 was due to a direct interaction of curcumin with AP-1-binding to its DNA binding motif.	Curcumin	67-75	Jun proto-oncogene, AP-1 transcription factor subunit	Bos taurus	81-85
9134658-9	1997	Thus, curcumin inhibits NF-kappa B and AP-1 by two different mechanisms and reduces expression of endothelial genes controlled by both transcription factors in vitro.	Curcumin	6-14	Jun proto-oncogene, AP-1 transcription factor subunit	Bos taurus	39-43
9439980-0	1997	Curcumin inhibits IL1 alpha and TNF-alpha induction of AP-1 and NF-kB DNA-binding activity in bone marrow stromal cells.	Curcumin	0-8	interleukin 1 alpha	Mus musculus	18-27
9439980-5	1997	These data suggest that inhibition of MCP-1/JE transcription by curcumin involves blocking of AP-1 and NF-kB activation by IL1 alpha or TNF-alpha.	Curcumin	64-72	interleukin 1 alpha	Mus musculus	123-132
8901798-7	1996	Curcumin treatment caused a significant induction of the glutathione S-transferase (GST) isozyme rGST8-8 in rat lens epithelium.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Rattus norvegicus	57-82
8901798-7	1996	Curcumin treatment caused a significant induction of the glutathione S-transferase (GST) isozyme rGST8-8 in rat lens epithelium.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Rattus norvegicus	84-87
8901798-7	1996	Curcumin treatment caused a significant induction of the glutathione S-transferase (GST) isozyme rGST8-8 in rat lens epithelium.	Curcumin	0-8	glutathione S-transferase alpha 4	Rattus norvegicus	97-104
8901798-8	1996	Because rGST8-8 utilizes 4-HNE as a preferred substrate, we suggest that the protective effect of curcumin may be mediated through the induction of this GST isozyme.	Curcumin	98-106	glutathione S-transferase alpha 4	Rattus norvegicus	8-15
8901798-8	1996	Because rGST8-8 utilizes 4-HNE as a preferred substrate, we suggest that the protective effect of curcumin may be mediated through the induction of this GST isozyme.	Curcumin	98-106	hematopoietic prostaglandin D synthase	Rattus norvegicus	9-12
8824830-1	1996	Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) inhibited noncompetitively rat liver microsomal delta 5 desaturase (Ki = 36 microM) and delta 6 desaturase (Ki = 28 microM).	Curcumin	0-8	fatty acid desaturase 2	Rattus norvegicus	159-177
8824830-6	1996	The following structural features of curcumin are necessary for the desaturase inhibition: (i) the aromatic ring conjugated with the double bond between the 1 and 2 (or 6 and 7) positions; (ii) both 4-hydroxy and 3-methoxy groups (for both desaturase inhibitions); and (iii) only a 4-hydroxy group (for delta 6 desaturase inhibition).	Curcumin	37-45	fatty acid desaturase 2	Rattus norvegicus	303-321
7602115-5	1995	Curcumin, a specific inhibitor of c-jun/AP-1, inhibited the cytokine-induced c-jun gene expression in a dose-dependent manner, though the c-fos gene expression was not affected.	Curcumin	0-8	FBJ osteosarcoma oncogene	Mus musculus	138-143
8538195-15	1995	Curcumin enhances glutathione content and glutathione-S-transferase activity in liver; and it inhibits lipid peroxidation and arachidonic acid metabolism in mouse skin, protein kinase C activity in TPA-treated NIH 3T3 cells, chemically induced ODC and tyrosine protein kinase activities in rat colon, and 8-hydroxyguanosine formation in mouse fibroblasts.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Mus musculus	42-67
7803521-2	1994	The short-term treatment of cells with Curcumin inhibited EGF receptor intrinsic kinase activity up to 90% in a dose- and time-dependent manner, and also inhibited EGF-induced tyrosine phosphorylation of EGF receptors.	Curcumin	39-47	epidermal growth factor	Homo sapiens	58-61
7803521-2	1994	The short-term treatment of cells with Curcumin inhibited EGF receptor intrinsic kinase activity up to 90% in a dose- and time-dependent manner, and also inhibited EGF-induced tyrosine phosphorylation of EGF receptors.	Curcumin	39-47	epidermal growth factor	Homo sapiens	164-167
7803521-2	1994	The short-term treatment of cells with Curcumin inhibited EGF receptor intrinsic kinase activity up to 90% in a dose- and time-dependent manner, and also inhibited EGF-induced tyrosine phosphorylation of EGF receptors.	Curcumin	39-47	epidermal growth factor	Homo sapiens	164-167
7954373-0	1994	Curcumin inhibits TPA induced expression of c-fos, c-jun and c-myc proto-oncogenes messenger RNAs in mouse skin.	Curcumin	0-8	FBJ osteosarcoma oncogene	Mus musculus	44-49
7954373-7	1994	In the present studies, we investigated the effect of curcumin on the expression of c-fos, c-jun and c-myc oncogenes in TPA-treated mouse skin in CD-1 mice.	Curcumin	54-62	FBJ osteosarcoma oncogene	Mus musculus	84-89
7954373-11	1994	A dose of 10 mumol of curcumin was found to inhibit 90% TPA-induced expression of c-fos and c-jun, and 60% of c-myc.	Curcumin	22-30	FBJ osteosarcoma oncogene	Mus musculus	82-87
7955078-14	1994	Application of 10 mumol curcumin to mouse skin twice a day for 5 days immediately after UVB exposure had only a small/variable inhibitory effect on UVB-induced increases in the expression of c-Fos and c-Jun and on epidermal hyperplasia.	Curcumin	24-32	FBJ osteosarcoma oncogene	Mus musculus	191-196
8242846-0	1993	Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon.	Curcumin	22-30	ornithine decarboxylase 1	Rattus norvegicus	55-78
8242846-7	1993	The results indicated that in saline-treated animals dietary curcumin significantly inhibited the ODC (P &lt; 0.001) and TPK (P &lt; 0.05) activities in the liver and colonic mucosa.	Curcumin	61-69	ornithine decarboxylase 1	Rattus norvegicus	98-101
8242846-8	1993	Dietary curcumin significantly decreased the levels of AOM-induced ODC activity in the liver and colon (P &lt; 0.0001) and TPK activity in the liver and colon (P &lt; 0.01-0.0001) and the formation of 5(S)-, 8(S)-, 12(S)- and 15(S)-hydroxyeicosatetraenoic acids (HETEs) in the liver and colon (P &lt; 0.0001).	Curcumin	8-16	ornithine decarboxylase 1	Rattus norvegicus	67-70
8510458-2	1993	Curcumine inhibited the 5-lipoxygenase activity in rat peritoneal neutrophils as well as the 12-lipoxygenase and the cyclooxygenase activities in human platelets.	Curcumin	0-9	arachidonate 5-lipoxygenase	Rattus norvegicus	24-38
35617284-0	2022	Extending the lore of curcumin as dipteran Butyrylcholine esterase (BChE) inhibitor: A holistic molecular interplay assessment.	Curcumin	22-30	butyrylcholinesterase	Homo sapiens	68-72
35617284-7	2022	Our research highlights that curcumin leads to inhibition of enzyme BChE of Ae.	Curcumin	29-37	butyrylcholinesterase	Homo sapiens	68-72
35617284-9	2022	The identified mode of action of curcumin as an insect BChE inhibitor indicates the possibility of its use as an environment friendly and natural futuristic insecticide.	Curcumin	33-41	butyrylcholinesterase	Homo sapiens	55-59
35606882-5	2022	The results of the present study showed that nano-curcumin can significantly reduce MCP-1 serum levels in the nano-curcumin supplemented group (P = 0.015, size effect = 13.4%).	Curcumin	50-58	C-C motif chemokine ligand 2	Homo sapiens	84-89
35606882-5	2022	The results of the present study showed that nano-curcumin can significantly reduce MCP-1 serum levels in the nano-curcumin supplemented group (P = 0.015, size effect = 13.4%).	Curcumin	115-123	C-C motif chemokine ligand 2	Homo sapiens	84-89
35507337-7	2022	Curcumin also significantly reduced the expression of GFAP (Glial fibrillary acidic protein) marker compared to untreated groups.	Curcumin	0-8	glial fibrillary acidic protein	Mus musculus	54-58
35507337-7	2022	Curcumin also significantly reduced the expression of GFAP (Glial fibrillary acidic protein) marker compared to untreated groups.	Curcumin	0-8	glial fibrillary acidic protein	Mus musculus	60-91
35179079-0	2022	Curcumin suppresses TGF-beta2-induced proliferation, migration, and invasion in lens epithelial cells by targeting KCNQ1OT1/miR-377-3p/COL1A2 axis in posterior capsule opacification.	Curcumin	0-8	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	115-123
35179079-9	2022	Curcumin-induced protective effects in TGF-beta2-induced SRA01/04 cells were largely overturned by KCNQ1OT1 overexpression.	Curcumin	0-8	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	99-107
35179079-15	2022	CONCLUSION: In conclusion, Curcumin suppressed TGF-beta2-induced malignant changes in lens epithelial cells by targeting KCNQ1OT1/miR-377-3p/COL1A2 axis.	Curcumin	27-35	KCNQ1 opposite strand/antisense transcript 1	Homo sapiens	121-129
35565795-6	2022	Furthermore, curcumin significantly down-regulated the expression of intestinal Niemann-Pick C1-like protein 1(NPC1L1) in hamsters and reduced cholesterol absorption in Caco-2 cells (p < 0.05).	Curcumin	13-21	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	111-117
35559378-7	2022	RESULTS: Network pharmacology suggested that curcumin treated EM through the HIF signaling pathway, of which IL-6, HIF-1alpha, and VEGFA are key targets.	Curcumin	45-53	hypoxia inducible factor 1, alpha subunit	Mus musculus	115-125
35421860-0	2022	Curcumin Attenuates Hydrocephalus via Activation of E2F Transcription Factor 4.	Curcumin	0-8	E2F transcription factor 4	Mus musculus	52-78
35421860-3	2022	Our previous studies demonstrated that E2F transcription factor 4 (E2F4) protein plays an important role in hydrocephalus; hence, we hypothesized that E2F4 may involve in curcumin mediated anti-hydrocephalus benefits.	Curcumin	171-179	E2F transcription factor 4	Mus musculus	39-65
35421860-3	2022	Our previous studies demonstrated that E2F transcription factor 4 (E2F4) protein plays an important role in hydrocephalus; hence, we hypothesized that E2F4 may involve in curcumin mediated anti-hydrocephalus benefits.	Curcumin	171-179	E2F transcription factor 4	Mus musculus	67-71
35450396-4	2022	During the research, the curcumin effect was evaluated by measuring cell survivability, expression of MMP1 gene, subcellular localization of P70S6K1 protein, and its phosphorylated form and amount of produced IL-6 and TNF-alpha.	Curcumin	25-33	matrix metallopeptidase 1	Homo sapiens	102-106
35450396-5	2022	Results of conducted experiments presented a positive impact of curcumin on synoviocytes in the RA model, by reducing SW982 cells" survivability, decreasing levels of MMP1 gene expression and TNF-alpha protein production, which altogether confirm beneficial effects of the curcumin therapy in a RA in vitro model.	Curcumin	64-72	matrix metallopeptidase 1	Homo sapiens	167-171
35453772-9	2022	CONCLUSIONS: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-alpha, INF, IL-6, and IL-10 1 h after the end of exercise.	Curcumin	13-21	cobalamin binding intrinsic factor	Homo sapiens	205-208
35400349-8	2022	Targeting MAPK/ERK, PI3k/AKT, Wnt/beta-catenin, Notch, and MircoRNA by curcumin has been evaluated to improve outcomes in patients with osteosarcoma.	Curcumin	71-79	catenin beta 1	Homo sapiens	34-46
34611905-4	2022	RESULTS: The encapsulation efficiency of curcumin was found to depend on LSP concentration and was highest (86.32%, w/w) at 50 mg mL-1 .	Curcumin	41-49	L1 cell adhesion molecule	Mus musculus	130-134
35409247-11	2022	CONCLUSIONS: The study first showed that Cur and DMC demonstrated antiangiogenic activity via the inhibition of endoglin/Smad1 signaling.	Curcumin	41-44	endoglin	Homo sapiens	112-120
35538036-0	2022	Curcumin ameliorates HO-induced injury through SIRT1-PERK-CHOP pathway in pancreatic beta cells.	Curcumin	0-8	sirtuin 1	Mus musculus	47-52
35538036-0	2022	Curcumin ameliorates HO-induced injury through SIRT1-PERK-CHOP pathway in pancreatic beta cells.	Curcumin	0-8	DNA-damage inducible transcript 3	Mus musculus	58-62
35538036-11	2022	Curcumin decreases ROS generation and inhibits protein kinase like ER kinase (PERK)-C/EBP homologous protein (CHOP) signaling axis, one of the critical branches of ER stress pathway.	Curcumin	0-8	DNA-damage inducible transcript 3	Mus musculus	110-114
35538036-12	2022	Moreover, incubation with curcumin activates silent information regulator 1 (SIRT1) expression and subsequently decreases the expression of CHOP.	Curcumin	26-34	sirtuin 1	Mus musculus	45-75
35538036-12	2022	Moreover, incubation with curcumin activates silent information regulator 1 (SIRT1) expression and subsequently decreases the expression of CHOP.	Curcumin	26-34	sirtuin 1	Mus musculus	77-82
35538036-12	2022	Moreover, incubation with curcumin activates silent information regulator 1 (SIRT1) expression and subsequently decreases the expression of CHOP.	Curcumin	26-34	DNA-damage inducible transcript 3	Mus musculus	140-144
35538036-13	2022	Additionally, EX527, a specific inhibitor of SIRT1, blocks the protective effect of curcumin on MIN6 cells exposed to HO.	Curcumin	84-92	sirtuin 1	Mus musculus	45-50
35538036-14	2022	In sum, curcumin inhibits the PERK-CHOP pathway of ER stress mediated by SIRT1 and thus ameliorates HO-induced MIN6 cell apoptosis, suggesting that curcumin and SIRT1 may provide a potential therapeutic approach for T1DM.	Curcumin	8-16	DNA-damage inducible transcript 3	Mus musculus	35-39
35538036-14	2022	In sum, curcumin inhibits the PERK-CHOP pathway of ER stress mediated by SIRT1 and thus ameliorates HO-induced MIN6 cell apoptosis, suggesting that curcumin and SIRT1 may provide a potential therapeutic approach for T1DM.	Curcumin	8-16	sirtuin 1	Mus musculus	73-78
35538036-14	2022	In sum, curcumin inhibits the PERK-CHOP pathway of ER stress mediated by SIRT1 and thus ameliorates HO-induced MIN6 cell apoptosis, suggesting that curcumin and SIRT1 may provide a potential therapeutic approach for T1DM.	Curcumin	148-156	DNA-damage inducible transcript 3	Mus musculus	35-39
35408502-6	2022	Interestingly, in contrast to the previously reported higher antioxidant- and NFkappaB-inhibitory activities of curcumin, DMC exhibited approximately two-fold stronger potency than curcumin against nanoparticle induced activation of NLRP3 inflammasome.	Curcumin	112-120	NLR family, pyrin domain containing 3	Mus musculus	233-238
35408502-6	2022	Interestingly, in contrast to the previously reported higher antioxidant- and NFkappaB-inhibitory activities of curcumin, DMC exhibited approximately two-fold stronger potency than curcumin against nanoparticle induced activation of NLRP3 inflammasome.	Curcumin	181-189	NLR family, pyrin domain containing 3	Mus musculus	233-238
35405942-0	2022	Investigation of the Effect of Curcumin on Protein Targets in NAFLD Using Bioinformatic Analysis.	Curcumin	31-39	TSC complex subunit 2	Mus musculus	62-67
35405942-5	2022	Here, bioinformatic tools, gene-drug and gene-disease databases were utilized to explore targets, interactions, and pathways through which curcumin could impact NAFLD.	Curcumin	139-147	TSC complex subunit 2	Mus musculus	161-166
35405942-15	2022	CONCLUSION: Curcumin may improve, or inhibit, progression of NAFLD through activation/inhibition of NAFLD-related genes.	Curcumin	12-20	TSC complex subunit 2	Mus musculus	61-66
35405942-15	2022	CONCLUSION: Curcumin may improve, or inhibit, progression of NAFLD through activation/inhibition of NAFLD-related genes.	Curcumin	12-20	TSC complex subunit 2	Mus musculus	100-105
35189522-0	2022	Protective role of curcumin on aflatoxin B1-induced TLR4/RIPK pathway mediated-necroptosis and inflammation in chicken liver.	Curcumin	19-27	toll like receptor 4	Gallus gallus	52-56
35189522-9	2022	Curcumin can regulate the TLR4/RIPK signaling pathway, reduced oxidative stress biomarkers and inflammatory cytokines levels and attenuated the expression of necroptosis and inflammation genes altered by AFB1 to reduce necroptosis of chicken liver tissue.	Curcumin	0-8	toll like receptor 4	Gallus gallus	26-30
35189522-10	2022	In conclusion, curcumin can protect against AFB1-induced necroptosis and inflammation by TLR4/RIPK pathway in chicken liver.	Curcumin	15-23	toll like receptor 4	Gallus gallus	89-93
35489078-11	2022	Additionaly, curcumin significantly decreased p-p38 MAPK positive cells and NFkB immunoreactivity, while significantly increasing Nrf2 immunoreactivity in the kidney tissue.	Curcumin	13-21	nuclear factor kappa B subunit 1	Rattus norvegicus	76-80
35489078-12	2022	CONCLUSION: We conclude that curcumin may attenuate gentamicininduced nephrotoxicity by supprresing the p38 MAPK and NFkB, and activating the Nrf2 signaling pathways.	Curcumin	29-37	nuclear factor kappa B subunit 1	Rattus norvegicus	117-121
35225298-9	2022	Curcumin-treated groups, with and without PZQ, resulted in higher significant Immunoreactivity score (IRS) for Bcl-2-associated X (BAX) and lower Interleukine- 17A (IL-17A), and Human epidermal growth factor (EGF), compared to the control.	Curcumin	0-8	epidermal growth factor	Homo sapiens	184-207
35225298-9	2022	Curcumin-treated groups, with and without PZQ, resulted in higher significant Immunoreactivity score (IRS) for Bcl-2-associated X (BAX) and lower Interleukine- 17A (IL-17A), and Human epidermal growth factor (EGF), compared to the control.	Curcumin	0-8	epidermal growth factor	Homo sapiens	209-212
35225298-11	2022	It was concluded that PZQ +curcumin treatment had a potent synergistic outcome through lessening the number of granulomas, the inflammatory events, and the expression of EGF, and amelioration of apoptosis in the periovulatory granulomas if compared with either PZQ or curcumin alone.	Curcumin	27-35	epidermal growth factor	Homo sapiens	170-173
35250410-11	2022	Moreover, Curc and Lip acid reduced the expression of alpha-smooth muscle actin and collagen III, upregulated by NHPA intoxication in response to oxidative stress and inflammation.	Curcumin	10-14	actin gamma 2, smooth muscle	Rattus norvegicus	54-79
35300350-11	2021	Curcumin can inhibit miR-21 expression and consequently activate apoptosis through caspase 3 and death receptor (DR) 4 and 5 activation.	Curcumin	0-8	microRNA 21	Homo sapiens	21-27
35015523-0	2022	Vitamin-H Channeled Self-Therapeutic P-gp Inhibitor Curcumin-Derived Nanomicelles for Targeting the Tumor Milieu by pH- and Enzyme-Triggered Hierarchical Disassembly.	Curcumin	52-60	phosphoglycolate phosphatase	Homo sapiens	37-41
35209134-0	2022	Mitochondrial ROS-Mediated Metabolic and Cytotoxic Effects of Isoproterenol on Cardiomyocytes Are p53-Dependent and Reversed by Curcumin.	Curcumin	128-136	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	98-101
35048742-1	2022	Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs).	Curcumin	22-30	sarcolipin	Mus musculus	84-87
35048742-4	2022	Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained.	Curcumin	35-43	sarcolipin	Mus musculus	16-19
35048742-7	2022	Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media.	Curcumin	72-80	sarcolipin	Mus musculus	40-43
35115932-0	2021	Curcumin Ameliorates Cardiac Fibrosis by Regulating Macrophage-Fibroblast Crosstalk via IL18-P-SMAD2/3 Signaling Pathway Inhibition.	Curcumin	0-8	interleukin 18	Rattus norvegicus	88-92
35115932-0	2021	Curcumin Ameliorates Cardiac Fibrosis by Regulating Macrophage-Fibroblast Crosstalk via IL18-P-SMAD2/3 Signaling Pathway Inhibition.	Curcumin	0-8	SMAD family member 2	Rattus norvegicus	95-102
35057429-8	2022	The significant therapeutic feature of curcumin is that it can affect the aging-related cellular proteins, i.e., amyloid and tau protein, preventing their aggregation and insolubility after ischemia.	Curcumin	39-47	microtubule associated protein tau	Homo sapiens	125-128
35057429-9	2022	Curcumin also decreases the neurotoxicity of amyloid and tau protein by affecting their structure.	Curcumin	0-8	microtubule associated protein tau	Homo sapiens	57-60
35264470-8	2022	Curcumin was found to decrease the number of T-helper 17 cells, downregulate T-helper-17 cell-related factors, reduce levels of T-helper-17 cell-related cytokines, yet increase the gene expression of Treg transcription factor forkhead box P3 (FOXP3), and decrease T-Box transcription factor 21 (TBX21).	Curcumin	0-8	T-box transcription factor 21	Homo sapiens	295-300
35549587-0	2022	Curcumin alleviated lipopolysaccharide-evoked H9c2 cells damage via suppression of intercellular adhesion molecule 1/CD40/NF-kappaB signaling.	Curcumin	0-8	CD40 molecule	Rattus norvegicus	117-121
35549587-10	2022	Inhibition of ICAM1 or CD40 strengthened the protective effect of curcumin on LPS-evoked H9c2 cells damage, accompanied by increased cell viability and decreased cell apoptosis and inflammation.	Curcumin	66-74	CD40 molecule	Rattus norvegicus	23-27
35549587-12	2022	CONCLUSIONS: Curcumin mitigated LPS-evoked H9c2 cells damage by suppression of ICAM1/CD40/NF-kappaB, providing a potential molecular mechanism for the clinical application of curcumin.	Curcumin	13-21	CD40 molecule	Rattus norvegicus	85-89
35549587-12	2022	CONCLUSIONS: Curcumin mitigated LPS-evoked H9c2 cells damage by suppression of ICAM1/CD40/NF-kappaB, providing a potential molecular mechanism for the clinical application of curcumin.	Curcumin	175-183	CD40 molecule	Rattus norvegicus	85-89
1418063-0	1992	Induction of glutathione S-transferase activity by curcumin in mice.	Curcumin	51-59	hematopoietic prostaglandin D synthase	Mus musculus	13-38
1418063-1	1992	Curcumin, a natural constituent of Curcuma longa (turmeric, CAS 458-37-7), has been studied for its induction of glutathione S-transferase activity in mice.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Mus musculus	113-138
33233354-9	2020	Further analysis identified a potential microRNA-mediated gene expression alteration in curcumin-treated IPF fibroblasts, namely, downregulated hsa-miR-6724-5p and upregulated KLF10.	Curcumin	88-96	Kruppel like factor 10	Homo sapiens	176-181
33233354-10	2020	Therefore, curcumin might decrease the level of hsa-miR-6724-5p, leading to increased KLF10 expression, resulting in cell cycle arrest in curcumin-treated IPF fibroblasts.	Curcumin	11-19	Kruppel like factor 10	Homo sapiens	86-91
33233354-10	2020	Therefore, curcumin might decrease the level of hsa-miR-6724-5p, leading to increased KLF10 expression, resulting in cell cycle arrest in curcumin-treated IPF fibroblasts.	Curcumin	138-146	Kruppel like factor 10	Homo sapiens	86-91
29058812-5	2018	Meanwhile, the impaction of Curcumin on miR-491, PEG10, and Wnt/beta-catenin signaling pathway were analyzed in HCT-116 cells.	Curcumin	28-36	catenin beta 1	Homo sapiens	64-76
29058812-10	2018	In addition, Curcumin could up-regulate miR-491, inhibit PEG10, and Wnt/beta-catenin signaling pathway.	Curcumin	13-21	catenin beta 1	Homo sapiens	72-84
29899871-9	2018	The KCC-1 type MSNs carrying curcumin displayed the highest anticancer activity.	Curcumin	29-37	solute carrier family 12 member 4	Homo sapiens	4-9
29570500-9	2018	Curcumin promoted PERK phosphorylation, and then Nrf2 dissociated from Keap1 and was translocated to the nucleus, which activated ATF4, an important bZIP transcription factor that maintains intracellular homeostasis, but inhibited the CHOP, a hallmark of ER stress and ER-associated programmed cell death.	Curcumin	0-8	DNA-damage inducible transcript 3	Rattus norvegicus	235-239
29453085-1	2018	In this study, a redox-sensitive glioma-targeting micelle system was designed to deliver curcumin (CUR) by conjugating it to hyaluronic acid (HA-s-s-CUR, HSC) via disulfide linkage.	Curcumin	89-97	fucosyltransferase 1 (H blood group)	Homo sapiens	154-157
26628981-0	2015	Curcumin protects against cerebral ischemia-reperfusion injury by activating JAK2/STAT3 signaling pathway in rats.	Curcumin	0-8	signal transducer and activator of transcription 3	Rattus norvegicus	82-87
34719837-0	2022	Inhibition of boldenone-induced aggression in rats by curcumin: Targeting TLR4/MyD88/TRAF-6/NF-kappaB pathway.	Curcumin	54-62	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	79-84
34719837-10	2022	Interestingly, curcumin mitigated boldenone-induced neurobehavioral disturbances in rats, normalized the oxidant/antioxidant balance, and suppressed TLR4/MyD88/TRAF-6/NF-kappaB pathway and its downstream proinflammatory signaling molecules TNF-alpha and IL-1beta.	Curcumin	15-23	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	154-159
34543634-0	2022	Curcumin improves angiogenesis in the heart of aged rats: Involvement of TSP1/NF-kappaB/VEGF-A signaling.	Curcumin	0-8	vascular endothelial growth factor A	Rattus norvegicus	88-94
34543634-6	2022	RESULTS: After 2 months, curcumin-age had significantly higher cardiac VEGF-A and NF-kappaB and lower cardiac TSP-1 expression levels in comparison with age and young.	Curcumin	25-33	vascular endothelial growth factor A	Rattus norvegicus	71-77
29453085-1	2018	In this study, a redox-sensitive glioma-targeting micelle system was designed to deliver curcumin (CUR) by conjugating it to hyaluronic acid (HA-s-s-CUR, HSC) via disulfide linkage.	Curcumin	99-102	fucosyltransferase 1 (H blood group)	Homo sapiens	154-157
29714206-0	2018	Curcumin Treatment is Associated with Increased Expression of the N-Methyl-D-Aspartate Receptor (NMDAR) Subunit, NR2A, in a Rat PC12 Cell Line Model of Alzheimer"s Disease Treated with the Acetyl Amyloid-beta Peptide, Abeta(25-35).	Curcumin	0-8	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	66-95
34945637-0	2021	Dietary Curcumin Alleviated Aflatoxin B1-Induced Acute Liver Damage in Ducks by Regulating NLRP3-Caspase-1 Signaling Pathways.	Curcumin	8-16	caspase-1	Anas platyrhynchos	97-106
29714206-0	2018	Curcumin Treatment is Associated with Increased Expression of the N-Methyl-D-Aspartate Receptor (NMDAR) Subunit, NR2A, in a Rat PC12 Cell Line Model of Alzheimer"s Disease Treated with the Acetyl Amyloid-beta Peptide, Abeta(25-35).	Curcumin	0-8	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	97-102
34945637-6	2021	Dietary curcumin significantly inhibited the generation of H2O2 and MDA in liver, activated the Nrf2-ARE signaling pathway, and suppressed the NLRP3-caspase-1 signaling pathway in the liver of ducks.	Curcumin	8-16	caspase-1	Anas platyrhynchos	149-158
34945637-7	2021	Conclusively, curcumin in diet could protect duck liver against the generation of AFB1-DNA adducts, toxicity, oxidation stress and inflammatory response induced by AFB1 through regulating the NLRP3-caspase-1 signaling pathways, demonstrating that curcumin is a potential feed additive agent to reduce the serious harmful effects of AFB1 on duck breeding.	Curcumin	14-22	caspase-1	Anas platyrhynchos	198-207
29714206-0	2018	Curcumin Treatment is Associated with Increased Expression of the N-Methyl-D-Aspartate Receptor (NMDAR) Subunit, NR2A, in a Rat PC12 Cell Line Model of Alzheimer"s Disease Treated with the Acetyl Amyloid-beta Peptide, Abeta(25-35).	Curcumin	0-8	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	113-117
34401962-11	2021	Additionally, curcumin attenuated memory deficits in Amyloid precursor protein transgenic (APPTG) mice.	Curcumin	14-22	amyloid beta (A4) precursor protein	Mus musculus	53-78
29714206-1	2018	BACKGROUND The aim of this study was to investigate the effect of curcumin treatment on the expression of the N-methyl-D-aspartate receptor (NMDAR) subunit, NR2A, in a rat PC12 cell line treated with the acetyl amyloid-beta peptide, Abeta(25-35), in an in vitro model of Alzheimer"s disease.	Curcumin	66-74	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	110-139
29714206-1	2018	BACKGROUND The aim of this study was to investigate the effect of curcumin treatment on the expression of the N-methyl-D-aspartate receptor (NMDAR) subunit, NR2A, in a rat PC12 cell line treated with the acetyl amyloid-beta peptide, Abeta(25-35), in an in vitro model of Alzheimer"s disease.	Curcumin	66-74	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	141-146
29714206-1	2018	BACKGROUND The aim of this study was to investigate the effect of curcumin treatment on the expression of the N-methyl-D-aspartate receptor (NMDAR) subunit, NR2A, in a rat PC12 cell line treated with the acetyl amyloid-beta peptide, Abeta(25-35), in an in vitro model of Alzheimer"s disease.	Curcumin	66-74	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	157-161
29714206-7	2018	Curcumin treatment of PC12 cells was associated with increased expression of the NMDAR subunit, NR2A.	Curcumin	0-8	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	81-86
29714206-8	2018	CONCLUSIONS The findings of this study showed a neuroprotective effect of curcumin treatment in an in vitro model of Alzheimer"s disease that was associated with the increased expression of the NMDAR subunit, NR2A.	Curcumin	74-82	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	194-199
34787055-6	2021	Considering the OMgp as the target protein, two flavonoid libraries (curcumin and piperine) were screened against it to get potential inhibitors.	Curcumin	69-77	oligodendrocyte myelin glycoprotein	Homo sapiens	16-20
34825004-13	2021	It was concluded that curcumin administered in combination with Glu-GNPs and X-ray irradiation could reduce the protein expression of VEGF, HSP90, HIF-1alpha, and MMP9 in tumor tissue when compared with the model group.	Curcumin	22-30	hypoxia inducible factor 1, alpha subunit	Mus musculus	147-157
29686295-0	2018	Curcumin interacts directly with the Cysteine 259 residue of STAT3 and induces apoptosis in H-Ras transformed human mammary epithelial cells.	Curcumin	0-8	HRas proto-oncogene, GTPase	Homo sapiens	92-97
29686295-4	2018	In the present study, we have found that curcumin inhibits STAT3 signaling that is persistently overactivated in H-Ras transformed breast epithelial cells (H-Ras MCF10A).	Curcumin	41-49	HRas proto-oncogene, GTPase	Homo sapiens	113-118
29686295-4	2018	In the present study, we have found that curcumin inhibits STAT3 signaling that is persistently overactivated in H-Ras transformed breast epithelial cells (H-Ras MCF10A).	Curcumin	41-49	HRas proto-oncogene, GTPase	Homo sapiens	156-161
29686295-7	2018	Site-directed mutation of this cysteine residue abolished curcumin-induced inactivation of STAT3 and apoptosis in H-Ras MCF10A cells.	Curcumin	58-66	HRas proto-oncogene, GTPase	Homo sapiens	114-119
29686295-8	2018	The alpha,beta-unsaturated carbonyl moiety of curcumin appears to be essential in its binding to STAT3 in H-Ras MCF10A cells.	Curcumin	46-54	HRas proto-oncogene, GTPase	Homo sapiens	106-111
34784955-0	2021	Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis.	Curcumin	0-8	pleckstrin homology domain containing M3	Homo sapiens	64-71
34784955-9	2021	Circ-PLEKHM3 was downregulated in ovarian cancer, and its expression could be promoted by curcumin treatment.	Curcumin	90-98	pleckstrin homology domain containing M3	Homo sapiens	5-12
27819521-0	2018	MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway.	Curcumin	52-60	sonic hedgehog signaling molecule	Homo sapiens	69-72
34784955-10	2021	Circ-PLEKHM3 overexpression exacerbated the effect of curcumin on ovarian cancer cell proliferation and apoptosis, as well as anti-tumor effect.	Curcumin	54-62	pleckstrin homology domain containing M3	Homo sapiens	5-12
34784955-15	2021	CONCLUSION: Curcumin restrained proliferation and facilitated apoptosis in ovarian cancer by regulating the circ-PLEKHM3/miR-320a/SMG1 axis.	Curcumin	12-20	pleckstrin homology domain containing M3	Homo sapiens	113-120
27819521-4	2018	Moreover, we found that combination treatment of miR-326 and curcumin caused significant inhibition of the SHH/GLI1 pathway in glioma cells compared with either treatment alone, independent of p53 status.	Curcumin	61-69	sonic hedgehog signaling molecule	Homo sapiens	107-110
34636389-5	2021	In addition, curcumin attenuated the increases in levels of miR-146a-5p and decreases in the expression of p-ERK signaling that would normally occur within CA1 regions of these depressed rats.	Curcumin	13-21	microRNA 146a	Rattus norvegicus	60-68
29219946-0	2018	C1206, a novel curcumin derivative, potently inhibits Hsp90 and human chronic myeloid leukemia cells in vitro.	Curcumin	15-23	heat shock protein 90 alpha family class A member 1	Homo sapiens	54-59
34636389-7	2021	One of the mechanisms for these beneficial effects of curcumin appears to involve the miR-146a-5p/ERK signaling pathway within the hippocampal CA1 region.	Curcumin	54-62	microRNA 146a	Rattus norvegicus	86-94
34812266-10	2021	Curcumin pretreatment strikingly increased the level of SOD, CAT, GPx, GSH, IL-10, IFN-gamma, and FRAP and significantly decreased MDA, Cr, BUN, IL-8, TNF-alpha, IL-6, and myeloperoxidase (MPO) expressions in tissues.	Curcumin	0-8	interleukin 10	Rattus norvegicus	76-81
34812266-10	2021	Curcumin pretreatment strikingly increased the level of SOD, CAT, GPx, GSH, IL-10, IFN-gamma, and FRAP and significantly decreased MDA, Cr, BUN, IL-8, TNF-alpha, IL-6, and myeloperoxidase (MPO) expressions in tissues.	Curcumin	0-8	interferon gamma	Rattus norvegicus	83-92
34812266-10	2021	Curcumin pretreatment strikingly increased the level of SOD, CAT, GPx, GSH, IL-10, IFN-gamma, and FRAP and significantly decreased MDA, Cr, BUN, IL-8, TNF-alpha, IL-6, and myeloperoxidase (MPO) expressions in tissues.	Curcumin	0-8	myeloperoxidase	Rattus norvegicus	172-187
34812266-10	2021	Curcumin pretreatment strikingly increased the level of SOD, CAT, GPx, GSH, IL-10, IFN-gamma, and FRAP and significantly decreased MDA, Cr, BUN, IL-8, TNF-alpha, IL-6, and myeloperoxidase (MPO) expressions in tissues.	Curcumin	0-8	myeloperoxidase	Rattus norvegicus	189-192
34758851-16	2021	Moreover, the inhibition of GSK-3beta reversed Nrf2 expression in curcumin-treated AsT, indicating that the decrease in Nrf2 is due to activation of the GSK-3beta/beta-TrCP ubiquitination pathway.	Curcumin	66-74	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	163-172
34758851-17	2021	Furthermore, in vitro and in vivo results showed that curcumin induced cell apoptosis, and had anti-angiogenesis and anti-tumorigenesis effects as a result of activating the GSK-3beta/beta-TrCP ubiquitination pathway and subsequent decrease in Nrf2.	Curcumin	54-62	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	184-193
29219946-1	2018	4-(4-Pyridinyl methylene) curcumin (C1206) is a new derivative of curcumin that is more active than curcumin in inhibition of heat shock protein 90 (Hsp90) and antitumor action.	Curcumin	26-34	heat shock protein 90 alpha family class A member 1	Homo sapiens	126-147
29219946-1	2018	4-(4-Pyridinyl methylene) curcumin (C1206) is a new derivative of curcumin that is more active than curcumin in inhibition of heat shock protein 90 (Hsp90) and antitumor action.	Curcumin	26-34	heat shock protein 90 alpha family class A member 1	Homo sapiens	149-154
29219946-1	2018	4-(4-Pyridinyl methylene) curcumin (C1206) is a new derivative of curcumin that is more active than curcumin in inhibition of heat shock protein 90 (Hsp90) and antitumor action.	Curcumin	66-74	heat shock protein 90 alpha family class A member 1	Homo sapiens	126-147
29219946-1	2018	4-(4-Pyridinyl methylene) curcumin (C1206) is a new derivative of curcumin that is more active than curcumin in inhibition of heat shock protein 90 (Hsp90) and antitumor action.	Curcumin	66-74	heat shock protein 90 alpha family class A member 1	Homo sapiens	149-154
28417445-0	2018	Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer.	Curcumin	28-36	erb-b2 receptor tyrosine kinase 2	Mus musculus	95-100
34795765-7	2021	Curcumin and BM-MSCs significantly (P < 0.05) improved the elevated TNF-alpha level and the lowered IL-10 level in the arthritic rats.	Curcumin	0-8	interleukin 10	Rattus norvegicus	100-105
28417445-1	2018	Curcumin has shown promising inhibitory activity against HER-2-positive tumor cells in vitro but suffers from poor oral bioavailability in vivo.	Curcumin	0-8	erb-b2 receptor tyrosine kinase 2	Mus musculus	57-62
34474346-0	2021	Curcumin analogue C66 attenuates obesity-induced myocardial injury by inhibiting JNK-mediated inflammation.	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	81-84
28417445-3	2018	The goal of this study was to examine the anticancer efficacy of curcumin-loaded polymeric microparticles in a transgenic mouse model of HER-2 cancer, Balb-neuT.	Curcumin	65-73	erb-b2 receptor tyrosine kinase 2	Mus musculus	137-142
34754622-18	2021	At a concentration of 20 muM curcumin cultured for 48 h, the expression of TGFB1 and GSTP1 in Hep3B cells was reduced significantly in qPCR analysis, and reduced TGFB1 protein expression was also found in Hep3B cells.	Curcumin	29-37	glutathione S-transferase pi 1	Homo sapiens	85-90
34657625-11	2021	PD98059 significantly attenuated the curcumin-stimulated TGF-betaRI, TGF-betaRII, and VEGF expression, whereas it had no effect on TGF-beta1 expression.	Curcumin	37-45	transforming growth factor beta receptor 1	Homo sapiens	57-67
34657625-12	2021	CONCLUSIONS: Curcumin upregulated TGF-beta1, TGF-betaRI, TGF-betaRII, and VEGF expression in an in vitro hGF wound healing model.	Curcumin	13-21	transforming growth factor beta receptor 1	Homo sapiens	45-55
34657625-13	2021	The ERK pathway is required for TGF-betaRI, TGF-betaRII, and VEGF induction by curcumin.	Curcumin	79-87	transforming growth factor beta receptor 1	Homo sapiens	32-42
34630845-0	2021	Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF-kappaB Suppression and NLRP3 Inflammasome Inhibition.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	143-148
34630845-6	2021	Furthermore, curcumin significantly reduced the number of gasdermin D+ (GSDMD+) Iba1+ and caspase-1+Iba1+ microglia/macrophage 21 days after stroke.	Curcumin	13-21	induction of brown adipocytes 1	Mus musculus	80-84
34630845-6	2021	Furthermore, curcumin significantly reduced the number of gasdermin D+ (GSDMD+) Iba1+ and caspase-1+Iba1+ microglia/macrophage 21 days after stroke.	Curcumin	13-21	induction of brown adipocytes 1	Mus musculus	100-104
34630845-8	2021	Western blot revealed a decrease in pyroptosis-related proteins, e.g., GSDMD-N, cleaved caspase-1, NLRP3, IL-1beta, and IL-18, following in vitro or in vivo curcumin treatment.	Curcumin	157-165	NLR family, pyrin domain containing 3	Mus musculus	99-104
34630845-8	2021	Western blot revealed a decrease in pyroptosis-related proteins, e.g., GSDMD-N, cleaved caspase-1, NLRP3, IL-1beta, and IL-18, following in vitro or in vivo curcumin treatment.	Curcumin	157-165	interleukin 1 alpha	Mus musculus	106-114
34630845-10	2021	NLRP3 knocked down by siRNA transfection markedly increased the inhibitory effects of curcumin on microglial pyroptosis and proinflammatory responses, both in vitro and in vivo.	Curcumin	86-94	NLR family, pyrin domain containing 3	Mus musculus	0-5
34630845-11	2021	Furthermore, stereotaxic microinjection of AAV-based NLRP3 shRNA significantly improved sensorimotor function and reduced WM lesion following curcumin treatment in MCAO mice.	Curcumin	142-150	NLR family, pyrin domain containing 3	Mus musculus	53-58
34630845-12	2021	Our study suggested that curcumin reduced stroke-induced WM damage, improved functional outcomes, and attenuated microglial pyroptosis, at least partially, through suppression of the NF-kappaB/NLRP3 signaling pathway, further supporting curcumin as a potential therapeutic drug for stroke.	Curcumin	25-33	NLR family, pyrin domain containing 3	Mus musculus	193-198
34641401-5	2021	When synergy was observed, for example with curcumin and irinotecan, this was unrelated to MET induction, as assessed by changes in E-cadherin and vimentin expression.	Curcumin	44-52	vimentin	Homo sapiens	147-155
34391121-1	2021	Amyloid beta (Abeta) aggregation inhibitor activity cliff involving a curcumin structure was predicted using the SAR Matrix method on the basis of 697 known Abeta inhibitors from ChEMBL (data set 2487).	Curcumin	70-78	amyloid beta (A4) precursor protein	Mus musculus	14-19
34391121-1	2021	Amyloid beta (Abeta) aggregation inhibitor activity cliff involving a curcumin structure was predicted using the SAR Matrix method on the basis of 697 known Abeta inhibitors from ChEMBL (data set 2487).	Curcumin	70-78	amyloid beta (A4) precursor protein	Mus musculus	157-162
34514978-13	2022	The binding energies were -7.8, -10, and -9.8 kcal/mol for curcumin, 2f and 3a with EGFR, respectively.	Curcumin	59-67	epidermal growth factor receptor	Mus musculus	84-88
34514978-15	2022	CONCLUSION: In summary, we found that fluorinated demethoxycurcumin and fluorinated curcumin induces cancer cell death and binds to EGFR with high affinity.	Curcumin	84-92	epidermal growth factor receptor	Mus musculus	132-136
34539332-9	2021	Moreover, in primary cultured rat dorsal root ganglion (DRG) neurons, curcumin significantly up-regulated the expression of proopiomelanocortin (Pomc) and promoted the release of beta-endorphin and enkephalin.	Curcumin	70-78	proenkephalin	Rattus norvegicus	198-208
34539332-10	2021	Furthermore, pretreatment with the antiserum of beta-endorphin or enkephalin markedly attenuated curcumin-induced analgesia in cancer-induced bone pain.	Curcumin	97-105	proenkephalin	Rattus norvegicus	66-76
34539332-12	2021	The results also suggested that stimulation of expression of DRG neurons beta-endorphin and enkephalin mediates the antinociceptive effect of curcumin in pain hypersensitivity conditions.	Curcumin	142-150	proenkephalin	Rattus norvegicus	92-102
34533799-1	2021	OBJECTIVE: To investigate the pharmacodynamic mechanism of curcumin against myocardial ischaemia-reperfusion injury by regulating the phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT)/rapamycin target protein (mTOR) signalling pathway.	Curcumin	59-67	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	134-163
34533799-7	2021	Curcumin can also down-regulate the expression of Bax and up-regulate the protein levels of Bcl2, p-mTOR and p-AKT (p < 0.05 or p < 0.01).	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	50-53
34405526-6	2021	Herein, we attempted to evaluate the anti-inflammatory effects of chronic oral administration of curcumin and HMGB1 expression in APP/PS1 transgenic mice AD model.	Curcumin	97-105	presenilin 1	Mus musculus	134-137
34405526-10	2021	In contrast, curcumin significantly decreased GFAP-positive cells, as assessed by immunofluorescence staining.	Curcumin	13-21	glial fibrillary acidic protein	Mus musculus	46-50
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Curcumin	44-52	microtubule associated protein tau	Homo sapiens	301-304
34225874-2	2021	Phosphatidylcholine (PC)-liposomes carrying curcumin (CURC), quercetin (QU), epigallocatechin gallate (EGCG) and rosmarinic acid (RA) with crosslinked glutathione (GSH) and apolipoprotein E (ApoE) were fabricated to recognize brain microvascular endothelial cells and amyloid beta (Abeta), and reduce tau protein hyperphosphorylation for AD management.	Curcumin	54-58	microtubule associated protein tau	Homo sapiens	301-304
34146894-4	2021	To this end, we detected transcription factor 6 (ATF6), the key factor of regulating lipid metabolism along with other related molecules (CHOP and GPR78) and found that curcumin significantly impaired the gene synthesis of ATF6, while CSFV infection promoted ATF6 expression.	Curcumin	169-177	activating transcription factor 6	Homo sapiens	49-53
34146894-4	2021	To this end, we detected transcription factor 6 (ATF6), the key factor of regulating lipid metabolism along with other related molecules (CHOP and GPR78) and found that curcumin significantly impaired the gene synthesis of ATF6, while CSFV infection promoted ATF6 expression.	Curcumin	169-177	activating transcription factor 6	Homo sapiens	223-227
34361702-2	2021	Over the last decade, many innovative curcumin-based compounds have been designed and synthesized, searching for new derivatives having anti-amyloidogenic, inhibitory of tau formation, as well as anti-neuroinflammation, antioxidative, and AChE inhibitory activities.	Curcumin	38-46	microtubule associated protein tau	Homo sapiens	170-173
34298639-6	2021	The current review has highlighted the anticancer activity of curcumin in hormone-independent breast cancer via focusing on its impact on key signaling pathways including the PI3K/Akt/mTOR pathway, JAK/STAT pathway, MAPK pathway, NF-kB pathway, p53 pathway, and Wnt/beta-catenin, as well as apoptotic and cell cycle pathways.	Curcumin	62-70	catenin beta 1	Homo sapiens	266-278
34145065-6	2021	RNase L inhibition with curcumin modulated and allogeneic hematopoietic cell transplantation cured the disorder.	Curcumin	24-32	ribonuclease L	Homo sapiens	0-7
34350255-0	2021	Curcumin exerts a protective effect on murine knee chondrocytes treated with IL-1beta through blocking the NF-kappaB/HIF-2alpha signaling pathway.	Curcumin	0-8	endothelial PAS domain protein 1	Mus musculus	117-127
34350255-9	2021	Results: Curcumin significantly inhibited the IL-1beta-induced reduction of cell viability, degradation of ECM, and the expression of SOX9, Col2alpha, and AGG (P<0.01).	Curcumin	9-17	interleukin 1 alpha	Mus musculus	46-54
34350255-10	2021	Western blotting, immunofluorescence and immunohistochemistry experiments demonstrated that curcumin dramatically inhibited the activation of NF-kappaB/HIF-2alpha in chondrocytes treated with IL-1beta (P<0.01).	Curcumin	92-100	endothelial PAS domain protein 1	Mus musculus	152-162
34350255-10	2021	Western blotting, immunofluorescence and immunohistochemistry experiments demonstrated that curcumin dramatically inhibited the activation of NF-kappaB/HIF-2alpha in chondrocytes treated with IL-1beta (P<0.01).	Curcumin	92-100	interleukin 1 alpha	Mus musculus	192-200
34350255-12	2021	Conclusions: Curcumin may have the potential to inhibit OA development, partly through suppressing the activation of the NF-kappaB/HIF-2alpha pathway.	Curcumin	13-21	endothelial PAS domain protein 1	Mus musculus	131-141
34103964-0	2021	Curcumin-Alleviated Osteoarthritic Progression in Rats Fed a High-Fat Diet by Inhibiting Apoptosis and Activating Autophagy via Modulation of MicroRNA-34a.	Curcumin	0-8	microRNA 34a	Rattus norvegicus	142-154
34103964-2	2021	This study aimed to determine whether curcumin exerts a chondroprotective effect by inhibiting apoptosis via upregulation of E2F1/PITX1 and activation of autophagy via the Akt/mTOR pathway by targeting microRNA-34a (miR-34a).	Curcumin	38-46	E2F transcription factor 1	Rattus norvegicus	125-129
34103964-2	2021	This study aimed to determine whether curcumin exerts a chondroprotective effect by inhibiting apoptosis via upregulation of E2F1/PITX1 and activation of autophagy via the Akt/mTOR pathway by targeting microRNA-34a (miR-34a).	Curcumin	38-46	microRNA 34a	Rattus norvegicus	202-214
34103964-2	2021	This study aimed to determine whether curcumin exerts a chondroprotective effect by inhibiting apoptosis via upregulation of E2F1/PITX1 and activation of autophagy via the Akt/mTOR pathway by targeting microRNA-34a (miR-34a).	Curcumin	38-46	microRNA 34a	Rattus norvegicus	216-223
34103964-12	2021	Greater numbers of apoptotic cells, lesser expression of p62, p-Akt, and p-mTOR, and greater expression of E2F1, PITX1, and LC3B were observed in the agomir-34a and high-dose curcumin-treated group than in agomir-34a and low-dose curcumin-treated group.	Curcumin	175-183	E2F transcription factor 1	Rattus norvegicus	107-111
34103964-13	2021	Conclusion: Curcumin"s chondroprotective effect was mediated by its suppression of miR-34a, apparently by reducing apoptosis, via upregulation of E2F1/PITX1, and by augmenting autophagy, likely via the Akt/mTOR pathway.	Curcumin	12-20	microRNA 34a	Rattus norvegicus	83-90
34103964-13	2021	Conclusion: Curcumin"s chondroprotective effect was mediated by its suppression of miR-34a, apparently by reducing apoptosis, via upregulation of E2F1/PITX1, and by augmenting autophagy, likely via the Akt/mTOR pathway.	Curcumin	12-20	E2F transcription factor 1	Rattus norvegicus	146-150
34065600-7	2021	Furthermore, curcumin-induced autophagy in human platelets via increased translocation of LC3I to LC3II, which was associated with activation of adenosine monophosphate (AMP) kinase and inhibition of protein kinase B activity.	Curcumin	13-21	protein tyrosine kinase 2 beta	Homo sapiens	200-216
34917292-8	2021	Conclusion: Different doses of curcumin adversely attenuated METH-induced apoptosis, oxidative stress, and inflammation but enhanced the concentrations of P-CREB and BDNF.	Curcumin	31-39	cAMP responsive element binding protein 1	Rattus norvegicus	157-161
34917292-9	2021	The neuroprotection caused by curcumin against METH-induced neurodegeneration is mediated through P-CREB-BDNF signaling pathway activation.	Curcumin	30-38	cAMP responsive element binding protein 1	Rattus norvegicus	100-104
34159091-0	2021	Curcumin plays a protective role against septic acute kidney injury by regulating the TLR9 signaling pathway.	Curcumin	0-8	toll-like receptor 9	Rattus norvegicus	86-90
34159091-5	2021	Results: The serum levels of UN, Cr, NF-kappaB, ALT, AST, amylase, CK, LDH, inflammatory factors TNF-alpha and IL-10, and markers of early diagnosis of SAKI (NGAL, CysC, KIM-1) were significantly lower in the curcumin group than those in the placebo group (P<0.05).	Curcumin	209-217	interleukin 10	Rattus norvegicus	111-116
34159091-5	2021	Results: The serum levels of UN, Cr, NF-kappaB, ALT, AST, amylase, CK, LDH, inflammatory factors TNF-alpha and IL-10, and markers of early diagnosis of SAKI (NGAL, CysC, KIM-1) were significantly lower in the curcumin group than those in the placebo group (P<0.05).	Curcumin	209-217	cystatin C	Rattus norvegicus	164-168
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Curcumin	169-177	interleukin 2	Rattus norvegicus	54-58
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Curcumin	341-349	interleukin 2	Rattus norvegicus	54-58
34148046-0	2021	Curcumin Affects Leptin-Induced Expression of Methionine Adenosyltransferase 2A in Hepatic Stellate Cells by Inhibition of JNK Signaling.	Curcumin	0-8	leptin	Homo sapiens	17-23
34148046-5	2021	Curcumin, an active polyphenol of the golden spice turmeric, inhibits leptin-induced HSC activation and liver fibrogenesis.	Curcumin	0-8	leptin	Mus musculus	70-76
34148046-9	2021	RESULTS: Curcumin reduced leptin-induced MAT2A expression.	Curcumin	9-17	leptin	Mus musculus	26-32
34148046-10	2021	JNK signaling contributed to leptin-induced increase in MAT2A level, which could be interrupted by curcumin treatment.	Curcumin	99-107	leptin	Mus musculus	29-35
34148046-12	2021	The effect of curcumin on leptin-induced MAT2A expression paralleled the reductions in leptin-induced activated HSCs and liver fibrosis.	Curcumin	14-22	leptin	Mus musculus	26-32
34148046-12	2021	The effect of curcumin on leptin-induced MAT2A expression paralleled the reductions in leptin-induced activated HSCs and liver fibrosis.	Curcumin	14-22	leptin	Mus musculus	87-93
35490921-9	2022	Curcumin prevented the change of expression of 13 proteins involved in oxidative phosphorylation (NDUFB8, NDUFB3, and ATP5L) in the cellular response to stress (PSMA5, HIST1H1D) and lipid metabolism (THRSP, DGAT1, ECI1, and ACOT13).	Curcumin	0-8	NADH:ubiquinone oxidoreductase subunit B3	Mus musculus	106-112
35490921-9	2022	Curcumin prevented the change of expression of 13 proteins involved in oxidative phosphorylation (NDUFB8, NDUFB3, and ATP5L) in the cellular response to stress (PSMA5, HIST1H1D) and lipid metabolism (THRSP, DGAT1, ECI1, and ACOT13).	Curcumin	0-8	diacylglycerol O-acyltransferase 1	Mus musculus	207-212
35490921-9	2022	Curcumin prevented the change of expression of 13 proteins involved in oxidative phosphorylation (NDUFB8, NDUFB3, and ATP5L) in the cellular response to stress (PSMA5, HIST1H1D) and lipid metabolism (THRSP, DGAT1, ECI1, and ACOT13).	Curcumin	0-8	enoyl-Coenzyme A delta isomerase 1	Mus musculus	214-218
35445729-8	2022	Some studies have previously demonstrated the possible advantage of the use of curcumin for the inhibition of Wnt/beta-catenin signaling.	Curcumin	79-87	catenin beta 1	Homo sapiens	114-126
35445729-9	2022	In the present review article, the different mechanisms of curcumin are described concerning its effects on oxidative stress, inflammation and angiogenesis in exudative AMD, by interacting with Wnt/beta-catenin signaling.	Curcumin	59-67	catenin beta 1	Homo sapiens	198-210
35487055-4	2022	MATERIAL AND METHODS: The human prostate cell lines (LNCaP and PC3) were treated with different concentrations of Curcumin and As2O3 alone and combined to find effective doses and IC50 values.	Curcumin	114-122	BTG anti-proliferation factor 2	Homo sapiens	63-66
35556131-3	2022	We evaluated the effects of curcumin supplementation on clinical scales and misfolded, phosphorylated alpha-synuclein (p-syn) accumulation in skin biopsies in 19 PD patients who received curcumin supplementation for 12 months and 14 PD patients to treated with curcumin.	Curcumin	28-36	synuclein alpha	Homo sapiens	102-117
35585935-0	2022	Curcumin Inhibits the Growth and Metastasis of Melanoma via miR-222-3p/SOX10/Notch Axis.	Curcumin	0-8	SRY-box transcription factor 10	Homo sapiens	71-76
35585935-5	2022	Immunofluorescence assay was used to demonstrate the effect of curcumin on SOX10 expression.	Curcumin	63-71	SRY-box transcription factor 10	Homo sapiens	75-80
35585935-11	2022	Furthermore, curcumin repress the expression of SOX10, Notch1, and HES-1, and increase the expression of miR-222-3p.	Curcumin	13-21	SRY-box transcription factor 10	Homo sapiens	48-53
35585935-14	2022	Conclusion: Curcumin enhances the miR-222-3p level to reduce SOX10 expression, and ultimately inactivates the Notch pathway in repressing melanoma proliferation, migration, and invasion.	Curcumin	12-20	SRY-box transcription factor 10	Homo sapiens	61-66
35564180-6	2022	In an in silico molecular docking study of the gallium-curcumin complex in PDI, calnexin, HSP60, PDK, caspase 9, Akt1 and PTEN were found to be strong binding.	Curcumin	55-63	caspase 9	Homo sapiens	102-111
35564180-6	2022	In an in silico molecular docking study of the gallium-curcumin complex in PDI, calnexin, HSP60, PDK, caspase 9, Akt1 and PTEN were found to be strong binding.	Curcumin	55-63	phosphatase and tensin homolog	Homo sapiens	122-126
35452417-0	2022	Therapeutic Effects of Curcumin on Osteoarthritis and Its Protection of Chondrocytes Through the Wnt/Beta-Catenin Signaling Pathway.	Curcumin	23-31	catenin beta 1	Homo sapiens	101-113
35421860-3	2022	Our previous studies demonstrated that E2F transcription factor 4 (E2F4) protein plays an important role in hydrocephalus; hence, we hypothesized that E2F4 may involve in curcumin mediated anti-hydrocephalus benefits.	Curcumin	171-179	E2F transcription factor 4	Mus musculus	151-155
35421860-9	2022	Upon curcumin administration, E2F4 expression level was increased, and the hydrocephalus severity score was significantly decreased in mouse model.	Curcumin	5-13	E2F transcription factor 4	Mus musculus	30-34
35421860-10	2022	Mechanistically, curcumin attenuated hydrocephalus through activating E2F4 signaling pathway.	Curcumin	17-25	E2F transcription factor 4	Mus musculus	70-74
35421860-11	2022	CONCLUSION: Curcumin suppresses hydrocephalus progression via activation of E2F4, which could be a target for hydrocephalus treatment.	Curcumin	12-20	E2F transcription factor 4	Mus musculus	76-80
35458704-7	2022	Although LPS increased AhR and its target gene CYP1B1, curcumin further enhanced LPS-induced CYP1B1 and indoleamine 2,3-dioxygenase (IDO), which metabolizes tryptophan to AhR ligands kynurenine (KYN) and kynurenic acid (KYNA).	Curcumin	55-63	indoleamine 2,3-dioxygenase 1	Homo sapiens	104-131
35458704-7	2022	Although LPS increased AhR and its target gene CYP1B1, curcumin further enhanced LPS-induced CYP1B1 and indoleamine 2,3-dioxygenase (IDO), which metabolizes tryptophan to AhR ligands kynurenine (KYN) and kynurenic acid (KYNA).	Curcumin	55-63	indoleamine 2,3-dioxygenase 1	Homo sapiens	133-136
35458704-12	2022	Curcumin may enhance the inflammation-induced IDO/KYN axis and allosterically regulate endogenous ligand binding to AhR, facilitating AhR activation to regulate inflammatory astrogliosis.	Curcumin	0-8	indoleamine 2,3-dioxygenase 1	Homo sapiens	46-49
35409397-7	2022	Interestingly, PDLSCs immunomodulation is significantly increased after curcumin treatment through activation of prostaglandin E2-Indoleamine 2,3 dioxygenase (PGE2-IDO) signaling, whereas inhibition of glycolysis activity by 2-deoxyglucose (2-DG) largely blocked immunomodulatory capacity of PDLSCs.	Curcumin	72-80	indoleamine 2,3-dioxygenase 1	Homo sapiens	164-167
35473503-0	2022	Curcumin relieved the rheumatoid arthritis progression via modulating the linc00052/miR-126-5p/PIAS2 axis.	Curcumin	0-8	microRNA 126	Homo sapiens	84-91
35473503-14	2022	These results reveal that curcumin protects against RA by regulating the inc00052/miR-126-5p/PIAS2 axis through JAK2/STAT3 signaling pathway.	Curcumin	26-34	microRNA 126	Homo sapiens	82-89
34994998-8	2022	Curcumin triggered apoptosis via reactive oxygen species (ROS) production, disruption of mitochondrial membrane potential (DeltaPsim), and intrinsic signaling (caspase-9/-3-dependent) pathways in A375.S2/VR cells.	Curcumin	0-8	caspase 9	Homo sapiens	160-169
35361044-0	2022	Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	34-38
35417322-9	2022	Using curcumin-loaded niosomes decreased immune cell influx and the inflammatory mediators (MIP-1alpha, TNF-alpha and IFN-gamma) production in the lung, resulting in alleviated lung pathology following RSV infection.	Curcumin	6-14	C-C motif chemokine ligand 3	Homo sapiens	92-102
35192145-7	2022	Curcumin attenuated TG-induced damage on cell viability and apoptosis and downregulated the protein levels of GRP78, pSer981-PERK, and pSer51-eIF2alpha.	Curcumin	0-8	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	125-129
35368919-6	2022	The impact of 10058-F4 and curcumin combination therapy on apoptosis and cell growth in SW1990 pancreatic cancer cells were determined in vitro using the CCK-8 assay and flow cytometry of Annexin V-FITC/PI, and the in vivo antitumor effect was determined utilizing SW1990-bearing pancreatic tumor mouse models induced by subcutaneous implantation.	Curcumin	27-35	annexin A5	Homo sapiens	188-197
35063475-0	2022	Curcumin mitigates aflatoxin B1-induced liver injury via regulating the NLRP3 inflammasome and Nrf2 signaling pathway.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	72-77
35184332-0	2022	Synergistic effect of curcumin and resveratrol on the prevention of contrast-induced nephropathy by suppressing inflammation via regulating signaling pathways of microRNA-17/TXNIP/NRLP3 and microRNA-30c/FOXO3/NRLP3.	Curcumin	22-30	microRNA 17	Rattus norvegicus	162-173
35189631-10	2022	Furthermore, curcumin positively regulated the expression of Nrf2, HO-1, and SOD1 mRNAs in cells treated with 0.1 and 0.5 muM doxazosin.	Curcumin	13-21	heme oxygenase 1	Homo sapiens	67-71
34998855-0	2022	Intranasal curcumin and dexamethasone combination ameliorates inflammasome (NLRP3) activation in lipopolysachharide exposed asthma exacerbations.	Curcumin	11-19	NLR family, pyrin domain containing 3	Mus musculus	76-81
34998855-2	2022	Present study is undertaken to investigate anti-inflammatory effects of a well known phytochemical, curcumin, which might regulate LPS exposed asthma exacerbations by modulating NLRP3 activation if given through intranasal route.	Curcumin	100-108	NLR family, pyrin domain containing 3	Mus musculus	178-183
35115932-12	2021	Mechanistically, we discovered that curcumin significantly downregulated pro-inflammatory cytokines in macrophages, which in turn inhibited IL18 expression in co-cultured cardiac fibroblasts using bulk RNA sequencing, and the TGF-beta1-p-SMAD2/3 signaling network was also discovered as the eventual target downstream of IL18 in curcumin-mediated anti-fibrosis signaling.	Curcumin	36-44	interleukin 18	Rattus norvegicus	140-144
35115932-12	2021	Mechanistically, we discovered that curcumin significantly downregulated pro-inflammatory cytokines in macrophages, which in turn inhibited IL18 expression in co-cultured cardiac fibroblasts using bulk RNA sequencing, and the TGF-beta1-p-SMAD2/3 signaling network was also discovered as the eventual target downstream of IL18 in curcumin-mediated anti-fibrosis signaling.	Curcumin	36-44	SMAD family member 2	Rattus norvegicus	238-245
35115932-12	2021	Mechanistically, we discovered that curcumin significantly downregulated pro-inflammatory cytokines in macrophages, which in turn inhibited IL18 expression in co-cultured cardiac fibroblasts using bulk RNA sequencing, and the TGF-beta1-p-SMAD2/3 signaling network was also discovered as the eventual target downstream of IL18 in curcumin-mediated anti-fibrosis signaling.	Curcumin	36-44	interleukin 18	Rattus norvegicus	321-325
34985280-3	2022	Here, we develop a self-oriented nanocarrier called PR-EXO/PP@Cur that combines therapeutic MSC-derived exosomes with curcumin.	Curcumin	118-126	5'-3' exoribonuclease 1	Mus musculus	55-58
34989253-0	2022	Curcumin improves atherosclerosis by inhibiting the epigenetic repression of lncRNA MIAT to miR-124.	Curcumin	0-8	myocardial infarction associated transcript (non-protein coding)	Mus musculus	84-88
34989253-11	2022	MIAT overexpression and miR-124 inhibition relieved the anti-inflammation effect of curcumin in ox-LDL-induced cell.	Curcumin	84-92	myocardial infarction associated transcript (non-protein coding)	Mus musculus	0-4
34989253-13	2022	Curcumin relieved ox-LDL-induced cell inflammation via regulating MIAT/miR-124 pathway.	Curcumin	0-8	myocardial infarction associated transcript (non-protein coding)	Mus musculus	66-70
34989253-14	2022	Conclusion: MIAT/miR-124 axis mediated the effect of curcumin on atherosclerosis and altered cell apoptosis and proliferation, both in vivo and in vitro.	Curcumin	53-61	myocardial infarction associated transcript (non-protein coding)	Mus musculus	12-16
29148846-7	2018	Caco-2 cells transport experiment exhibited that while soluplus and solutol HS15 were self-assembled into micelles, it could not only promote the permeability of curcumin across membrane for better absorption, but also could restrain the curcumin pumped outside due to the role of P-gp efflux mechanism of soluplus and solutol HS15.	Curcumin	162-170	phosphoglycolate phosphatase	Homo sapiens	281-285
29545895-0	2018	Curcumin inhibits the growth of liver cancer stem cells through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway.	Curcumin	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	68-97
29545895-0	2018	Curcumin inhibits the growth of liver cancer stem cells through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway.	Curcumin	0-8	protein tyrosine kinase 2 beta	Homo sapiens	98-114
29545895-6	2018	Further experiments revealed that treatment with curcumin inhibited that the activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway.	Curcumin	49-57	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	95-124
29545895-6	2018	Further experiments revealed that treatment with curcumin inhibited that the activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway.	Curcumin	49-57	protein tyrosine kinase 2 beta	Homo sapiens	132-148
29027056-8	2018	Curcumin supplementation prevented the LPS-induced upregulation in the protein activity of transcription factor NFkappaB, proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-1alpha), inducible nitric oxide synthase (iNOS) as well as the regulating molecules of the intrinsic apoptotic pathway (Bax, Bcl-2, Caspase 3 and Caspase 9) by ELISA.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	297-300
29162464-0	2018	Biochemical and Biophysical characterization of curcumin binding to human mitotic kinesin Eg5: Insights into the inhibitory mechanism of curcumin on Eg5.	Curcumin	48-56	kinesin family member 11	Homo sapiens	90-93
29162464-0	2018	Biochemical and Biophysical characterization of curcumin binding to human mitotic kinesin Eg5: Insights into the inhibitory mechanism of curcumin on Eg5.	Curcumin	48-56	kinesin family member 11	Homo sapiens	149-152
29162464-0	2018	Biochemical and Biophysical characterization of curcumin binding to human mitotic kinesin Eg5: Insights into the inhibitory mechanism of curcumin on Eg5.	Curcumin	137-145	kinesin family member 11	Homo sapiens	90-93
33388343-8	2021	This suggests that RBP on the surface of RBP-exo may interact with RAGE and increase the intracellular delivery efficiency of curcumin.	Curcumin	126-134	retinol binding protein 4	Homo sapiens	19-22
29162464-0	2018	Biochemical and Biophysical characterization of curcumin binding to human mitotic kinesin Eg5: Insights into the inhibitory mechanism of curcumin on Eg5.	Curcumin	137-145	kinesin family member 11	Homo sapiens	149-152
33388343-8	2021	This suggests that RBP on the surface of RBP-exo may interact with RAGE and increase the intracellular delivery efficiency of curcumin.	Curcumin	126-134	advanced glycosylation end-product specific receptor	Homo sapiens	67-71
29162464-1	2018	In this study we have characterized the biochemical and biophysical interactions of curcumin with the mitotic kinesin Eg5 which plays a pivotal role in the separation of centrosomes during cell division.	Curcumin	84-92	kinesin family member 11	Homo sapiens	118-121
33388343-9	2021	In addition, RBP-exo/Cur had higher anti-inflammatory effects than curcumin alone, a mixture of RBP and curcumin, and unmod-exo/Cur in vitro.	Curcumin	104-112	retinol binding protein 4	Homo sapiens	13-16
29162464-2	2018	Curcumin bound to the purified Eg5 (Eg5-437H) with a Kd value of 7.8muM.	Curcumin	0-8	kinesin family member 11	Homo sapiens	31-34
32780358-7	2021	Thus, based on the obtained results, the expression of c-kit, STRA8, and PCNA genes was significantly increased in treatment groups by curcumin-loaded iron particles compared with scrotal hyperthermia-induced mice.	Curcumin	135-143	proliferating cell nuclear antigen	Mus musculus	73-77
29455005-0	2018	Could curcumin protect the dendritic trees of the CA1 neurons from shortening and shedding induced by chronic sleep restriction in rats?	Curcumin	6-14	carbonic anhydrase 1	Rattus norvegicus	50-53
33531802-17	2021	Besides, CXCR 4 expression was detected about 30-fold less than curcumin alone.	Curcumin	64-72	C-X-C motif chemokine receptor 4	Homo sapiens	9-15
29393445-3	2018	The effects of JAK2/STAT3 inhibitor and curcumin on the expression of p-JAK2, p-STAT3, HMGB1, and inflammatory factors after cerebral ischemia were observed with ELISA, western blotting and immunohistochemical staining.	Curcumin	40-48	signal transducer and activator of transcription 3	Rattus norvegicus	80-85
29552196-10	2018	RT-qPCR demonstrated that treatment with curcumin was able to significantly increase the levels of CLTC and ITPR1 mRNA in curcumin-treated cells compared with control.	Curcumin	41-49	clathrin heavy chain	Homo sapiens	99-103
33520933-6	2020	By conjugation of CD44 cell-surface glycoprotein with poly(lactic-co-glycolic acid) (PLGA) nanoparticles that are loaded with curcumin and salinomycin, we investigated the cellular uptake of BCSCs, drug release, and therapeutic efficacy against BCSCs.	Curcumin	126-134	CD44 molecule (Indian blood group)	Homo sapiens	18-22
29552196-10	2018	RT-qPCR demonstrated that treatment with curcumin was able to significantly increase the levels of CLTC and ITPR1 mRNA in curcumin-treated cells compared with control.	Curcumin	122-130	clathrin heavy chain	Homo sapiens	99-103
29606874-8	2018	Results: The release kinetics showed that both Fab"-Cur-NPs and TMAB-Cur-NPs provided continuous, slow release of curcumin for 72 h, with no significant difference.	Curcumin	114-122	FA complementation group B	Homo sapiens	47-50
32767266-5	2021	The cell-permeant, 2-amino-ethoxy-diphenyl-borate (2-APB; 100 muM) and curcumin (50 muM) were used as the inhibitors of IP3R/s.	Curcumin	71-79	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	120-124
29356693-0	2018	Sonic hedgehog and Wnt/beta-catenin pathways mediate curcumin inhibition of breast cancer stem cells.	Curcumin	53-61	sonic hedgehog signaling molecule	Homo sapiens	0-14
33087639-0	2021	Preclinical pharmacokinetics, tissue distribution and primary safety evaluation of a novel curcumin analogue H10 suspension, a potential 17beta hydroxysteroid dehydrogenase type 3 inhibitor.	Curcumin	91-99	H1.0 linker histone	Homo sapiens	109-112
32392119-0	2021	Possible Protective Effects of Curcumin via Modulating of Androgen Receptor (AR) and Oct2 Gene Alterations in Cisplatin-Induced Testicular Toxicity in Rat.	Curcumin	31-39	androgen receptor	Rattus norvegicus	58-75
32392119-0	2021	Possible Protective Effects of Curcumin via Modulating of Androgen Receptor (AR) and Oct2 Gene Alterations in Cisplatin-Induced Testicular Toxicity in Rat.	Curcumin	31-39	androgen receptor	Rattus norvegicus	77-79
33017608-0	2021	Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKCbeta/p66Shc axis and activation of FOXO-3a.	Curcumin	0-8	protein kinase C, alpha	Rattus norvegicus	99-106
29356693-0	2018	Sonic hedgehog and Wnt/beta-catenin pathways mediate curcumin inhibition of breast cancer stem cells.	Curcumin	53-61	catenin beta 1	Homo sapiens	23-35
33017608-7	2021	In the kidneys of both control and diabetic rats, Curcumin reduced the levels of reactive oxygen species (ROS), increased mRNA levels of manganese superoxide dismutase (MnSOD) and gamma-glutamyl ligase (GCL-c), increased glutathione (GSH) and protein levels of Bcl-2 and MnSOD, and increased the nuclear levels of nuclear factor2 (Nrf2) and FOXO-3a.	Curcumin	50-58	superoxide dismutase 2	Rattus norvegicus	137-167
33017608-7	2021	In the kidneys of both control and diabetic rats, Curcumin reduced the levels of reactive oxygen species (ROS), increased mRNA levels of manganese superoxide dismutase (MnSOD) and gamma-glutamyl ligase (GCL-c), increased glutathione (GSH) and protein levels of Bcl-2 and MnSOD, and increased the nuclear levels of nuclear factor2 (Nrf2) and FOXO-3a.	Curcumin	50-58	superoxide dismutase 2	Rattus norvegicus	169-174
29356693-7	2018	We further illustrated that curcumin effectively decreased breast CSCs activity by inhibiting tumor sphere formation, decreasing breast CSCs markers (CD44, ALDH1A1, Nanog, and Oct4), as well as inhibiting proliferation and inducing apoptosis.	Curcumin	28-36	aldehyde dehydrogenase 1 family member A1	Homo sapiens	156-163
33017608-7	2021	In the kidneys of both control and diabetic rats, Curcumin reduced the levels of reactive oxygen species (ROS), increased mRNA levels of manganese superoxide dismutase (MnSOD) and gamma-glutamyl ligase (GCL-c), increased glutathione (GSH) and protein levels of Bcl-2 and MnSOD, and increased the nuclear levels of nuclear factor2 (Nrf2) and FOXO-3a.	Curcumin	50-58	superoxide dismutase 2	Rattus norvegicus	271-276
29356693-7	2018	We further illustrated that curcumin effectively decreased breast CSCs activity by inhibiting tumor sphere formation, decreasing breast CSCs markers (CD44, ALDH1A1, Nanog, and Oct4), as well as inhibiting proliferation and inducing apoptosis.	Curcumin	28-36	POU class 5 homeobox 1	Homo sapiens	176-180
29356693-8	2018	Moreover, we showed that downregulation of Shh and Wnt/beta-catenin activity resulted in breast CSCs inhibition; curcumin exerted an inhibitory effect on breast CSCs by suppressing both Shh and Wnt/beta-catenin pathways.	Curcumin	113-121	sonic hedgehog signaling molecule	Homo sapiens	186-189
29356693-8	2018	Moreover, we showed that downregulation of Shh and Wnt/beta-catenin activity resulted in breast CSCs inhibition; curcumin exerted an inhibitory effect on breast CSCs by suppressing both Shh and Wnt/beta-catenin pathways.	Curcumin	113-121	catenin beta 1	Homo sapiens	198-210
31162984-10	2021	Autophagy was enhanced and Akt/mTOR pathway was inhibited by curcumin.	Curcumin	61-69	mechanistic target of rapamycin kinase	Rattus norvegicus	31-35
31162984-12	2021	Conclusion: Curcumin may exert its therapeutic effect on SCI through the enhancement of autophagy, in which, inhibition of the Akt/mTOR signaling pathway may be also involved.	Curcumin	12-20	mechanistic target of rapamycin kinase	Rattus norvegicus	131-135
29356693-9	2018	Taken together, these results indicated curcumin inhibition of breast CSCs by downregulation of Shh and Wnt/beta-catenin pathways.	Curcumin	40-48	sonic hedgehog signaling molecule	Homo sapiens	96-99
33335121-0	2020	Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway.	Curcumin	0-8	brain derived neurotrophic factor	Homo sapiens	87-91
29356693-9	2018	Taken together, these results indicated curcumin inhibition of breast CSCs by downregulation of Shh and Wnt/beta-catenin pathways.	Curcumin	40-48	catenin beta 1	Homo sapiens	108-120
33335121-6	2020	Blocking the BDNF/TrkB pathway reversed the neuroprotective effects of curcumin, which were imparted by decreasing the PRV-induced upregulation of nitric oxide synthase expression, repressing the PRV-activated mitochondrial apoptotic pathway, and mitochondrial dysfunction.	Curcumin	71-79	brain derived neurotrophic factor	Homo sapiens	13-17
29139094-13	2018	CONCLUSION: Curcumin might have therapeutic potential in breast cancer through regulating breast cancer-related genes, including SERPINE1, PGAP3, MAP3K1, MAPK1, GSTO2, VIM, SPARC, and FGF2.	Curcumin	12-20	vimentin	Homo sapiens	168-171
33335121-7	2020	To conclude, curcumin exhibited a neuroprotective role against PRV infection by upregulating the BDNF/TrkB pathway.	Curcumin	13-21	brain derived neurotrophic factor	Homo sapiens	97-101
29139094-13	2018	CONCLUSION: Curcumin might have therapeutic potential in breast cancer through regulating breast cancer-related genes, including SERPINE1, PGAP3, MAP3K1, MAPK1, GSTO2, VIM, SPARC, and FGF2.	Curcumin	12-20	secreted protein acidic and cysteine rich	Homo sapiens	173-178
33058920-5	2020	Further reactivation of RB1 expression by curcumin could inhibit gastric cell viability and carcinogenesis both in vitro and in vivo.	Curcumin	42-50	RB transcriptional corepressor 1	Mus musculus	24-27
29405636-0	2018	Dietary Curcumin Intervention Targets Mouse White Adipose Tissue Inflammation and Brown Adipose Tissue UCP1 Expression.	Curcumin	8-16	WD and tetratricopeptide repeats 1	Mus musculus	50-57
29405636-0	2018	Dietary Curcumin Intervention Targets Mouse White Adipose Tissue Inflammation and Brown Adipose Tissue UCP1 Expression.	Curcumin	8-16	WD and tetratricopeptide repeats 1	Mus musculus	88-95
29405636-1	2018	OBJECTIVE: This study aimed to determine whether dietary curcumin intervention targets both white adipose tissue (WAT) inflammation and brown adipose tissue (BAT)-mediated energy expenditure.	Curcumin	57-65	WD and tetratricopeptide repeats 1	Mus musculus	98-105
29405636-1	2018	OBJECTIVE: This study aimed to determine whether dietary curcumin intervention targets both white adipose tissue (WAT) inflammation and brown adipose tissue (BAT)-mediated energy expenditure.	Curcumin	57-65	WD and tetratricopeptide repeats 1	Mus musculus	142-149
32597247-1	2020	The novel curcumin analog C086, previously identified as an oral novel heat shock protein 90 (Hsp90) inhibitor, was found to exhibit anti-hepatoma activity in vitro and in vivo.	Curcumin	10-18	heat shock protein, 2	Mus musculus	71-92
32597247-1	2020	The novel curcumin analog C086, previously identified as an oral novel heat shock protein 90 (Hsp90) inhibitor, was found to exhibit anti-hepatoma activity in vitro and in vivo.	Curcumin	10-18	heat shock protein, 2	Mus musculus	94-99
29353037-2	2018	Post oxygen and glucose deprivation/reoxygenation (OGD/R), primary mouse cortical neurons treated with curcumin exhibited a significant decrease in cell death, LDH release and enzyme caspase-3 activity under OGD/R circumstances, which were abolished by flotillin-1 downregulation or extracellular signal-regulated kinase (ERK) inhibitor.	Curcumin	103-111	flotillin 1	Mus musculus	253-264
29353037-3	2018	Moreover, flotillin-1 knockdown led to suppression of curcumin-mediated ERK phosphorylation under OGD/R condition.	Curcumin	54-62	flotillin 1	Mus musculus	10-21
29353037-4	2018	Based on these findings, we concluded that curcumin could confer neuroprotection against OGD/R injury through a novel flotillin-1 and ERK1/2 pathway.	Curcumin	43-51	flotillin 1	Mus musculus	118-129
28905939-6	2018	Curcumin administration significantly suppressed the deposition of type I and type III collagens in the heart tissues of diabetic rats, accompanied by markedly reduced TGF-beta1 production, suppressed TbetaR II levels and Smad2/3 phosphorylation, and increased Smad7 expression.	Curcumin	0-8	SMAD family member 2	Rattus norvegicus	222-229
32920425-4	2020	Compound 2 and curcumin were further investigated by preparing HSA-bound nanoparticles (NP-2 and NP-CCM) to surmount the difficulties mentioned above.	Curcumin	15-23	neuropilin 2	Homo sapiens	88-92
31854220-5	2020	The expression of MAPK, NF-kappaB, MMP9, MMP2 and vimentin were confirmed by RT-PCR, immunohistochemistry or western blotting.Results: Administration of curcumin significantly inhibited tumour growth, as the tumour weight decreased from 0.67 g (control) to 0.47 g (15 mg/kg) and 0.35 g (30 mg/kg).	Curcumin	153-161	matrix metallopeptidase 9	Homo sapiens	35-39
31854220-8	2020	Moreover, curcumin attenuated the mRNA transcription and protein expression of MMP2 and MMP9.	Curcumin	10-18	matrix metallopeptidase 9	Homo sapiens	88-92
28902433-14	2018	Curcumin also regulated the BLM and IL-17A mediated changes in p53-PAI-1 expression.	Curcumin	0-8	serpin family E member 1	Homo sapiens	67-72
32866059-9	2020	Moreover, curcumin reduced the levels of IL-6, IL-1beta and TNF-alpha by 22.5%, 30.3% and 26.7%, respectively, and suppressed vimentin expression in UUO mice.	Curcumin	10-18	vimentin	Mus musculus	126-134
28902433-15	2018	Curcumin has the ability to regulate inflammatory cytokines during BLM-induced injury and their effect on p53-PAI-1 expression.	Curcumin	0-8	serpin family E member 1	Homo sapiens	110-115
32866059-10	2020	In vitro, curcumin reduced the expression of vimentin and alpha-smooth muscle actin in TGF-beta1-induced HK-2 cells.	Curcumin	10-18	vimentin	Mus musculus	45-53
29034440-9	2018	Furthermore, curcumin repressed the capacity of risperidone to induce the hepatic over expression of enzymes involved in lipid metabolism (LXRalpha, FAS, ACC1, LPL, PPARgamma, ACO, SREBP2) and decreased risperidone-induced glucose intolerance and hypertriglyceridemia.	Curcumin	13-21	acetyl-Coenzyme A carboxylase alpha	Mus musculus	154-158
30608040-11	2018	Finally, we showed a good additive effect of MDA- 9/Syntenin siRNA when associated with Curcumin or Doxorubicin on cell growth inhibition.	Curcumin	88-96	syndecan binding protein	Homo sapiens	45-51
33011251-8	2020	Fourier transform infrared spectroscopy and X-ray diffraction characterizations of the fabricated fibrous materials exhibited the interaction of PCL/PEO, n-HA, and curcumin.	Curcumin	164-172	PHD finger protein 1	Homo sapiens	145-148
33473285-0	2021	Curcumin inhibits the proteolytic process of SREBP-2 by first inhibiting the expression of S1P rather than directly inhibiting SREBP-2 expression.	Curcumin	0-8	membrane bound transcription factor peptidase, site 1	Homo sapiens	91-94
30608040-11	2018	Finally, we showed a good additive effect of MDA- 9/Syntenin siRNA when associated with Curcumin or Doxorubicin on cell growth inhibition.	Curcumin	88-96	syndecan binding protein	Homo sapiens	52-60
33473285-2	2021	This study was designed to demonstrate that curcumin inhibits the proteolytic process of SREBP-2 by first inhibiting the expression of membrane-bound transcription factor site-1 protease (S1P) rather than directly inhibiting SREBP-2 expression.	Curcumin	44-52	membrane bound transcription factor peptidase, site 1	Homo sapiens	135-186
33473285-2	2021	This study was designed to demonstrate that curcumin inhibits the proteolytic process of SREBP-2 by first inhibiting the expression of membrane-bound transcription factor site-1 protease (S1P) rather than directly inhibiting SREBP-2 expression.	Curcumin	44-52	membrane bound transcription factor peptidase, site 1	Homo sapiens	188-191
30055545-0	2018	Modulatory Potential of Curcumin and Resveratrol on p53 Post-Translational Modifications during Gastric Cancer.	Curcumin	24-32	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	52-55
33473285-6	2021	Curcumin can inhibit the proteolytic process of SREBP-2, reduce the production of mature SREBP-2 (mSREBP-2), and change the cellular distribution of SREBP-2.	Curcumin	0-8	sterol regulatory element binding factor 2	Mus musculus	98-106
33473285-8	2021	Curcumin could downregulate the mRNA and protein expression of S1P, but has no obvious inhibitory effect on the mRNA and protein expression of S2P (site-2 protease).	Curcumin	0-8	membrane bound transcription factor peptidase, site 1	Homo sapiens	63-66
28780751-0	2018	Role of curcumin in PLD activation by Arf6-cytohesin1 signaling axis in U46619-stimulated pulmonary artery smooth muscle cells.	Curcumin	8-16	ADP ribosylation factor 6	Homo sapiens	38-42
33473285-9	2021	Curcumin can inhibit the SREBP-2 proteolytic process to reduce mSREBP-2 which functions as a transcription factor, affecting the regulation of cholesterol metabolism-related genes.	Curcumin	0-8	sterol regulatory element binding factor 2	Mus musculus	63-71
28780751-7	2018	Upon treatment of the cells with U46619, Arf-6 and cytohesin-1 were translocated and associated in the cell membrane, which were not inhibited upon pretreatment of the cells with curcumin.	Curcumin	179-187	ADP ribosylation factor 6	Homo sapiens	41-46
33473285-10	2021	Curcumin does not directly inhibit the expression of mSREBP-2 protein, and it has no such inhibitory effect for at least a short period of time, although curcumin does reduce the amount of mSREBP-2 protein.	Curcumin	154-162	sterol regulatory element binding factor 2	Mus musculus	189-197
33473285-12	2021	Therefore, curcumin may decrease the amount of mSREBP-2 by directly inhibiting the expression of S1P mRNA and protein.	Curcumin	11-19	sterol regulatory element binding factor 2	Mus musculus	47-55
28780751-8	2018	Cytohesin-1 appeared to be necessary for in vitro binding of GTPgammaS with Arf-6; however, addition of curcumin inhibited binding of GTPgammaS with Arf-6 even in the presence of cytohesin-1.	Curcumin	104-112	ADP ribosylation factor 6	Homo sapiens	149-154
33473285-12	2021	Therefore, curcumin may decrease the amount of mSREBP-2 by directly inhibiting the expression of S1P mRNA and protein.	Curcumin	11-19	membrane bound transcription factor peptidase, site 1	Homo sapiens	97-100
29115530-13	2018	The results of the present study suggest that the hepatic Notch-1 pathway can be suppressed via curcumin treatment, which may ameliorate fatty liver and insulin resistance in rats subjected to a high fat diet.	Curcumin	96-104	notch receptor 1	Rattus norvegicus	58-65
33204708-0	2020	Curcumin Improves the Renal Autophagy in Rat Experimental Membranous Nephropathy via Regulating the PI3K/AKT/mTOR and Nrf2/HO-1 Signaling Pathways.	Curcumin	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	109-113
33204708-0	2020	Curcumin Improves the Renal Autophagy in Rat Experimental Membranous Nephropathy via Regulating the PI3K/AKT/mTOR and Nrf2/HO-1 Signaling Pathways.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	123-127
33204708-14	2020	In addition, curcumin downregulated the expression of Bax, Caspase-3, p62, PI3K, p-AKT, and p-mTOR proteins and upregulated the Bcl-2, beclin1, LC3, Nrf2, and HO-1 levels in this animal model.	Curcumin	13-21	mechanistic target of rapamycin kinase	Rattus norvegicus	94-98
33204708-14	2020	In addition, curcumin downregulated the expression of Bax, Caspase-3, p62, PI3K, p-AKT, and p-mTOR proteins and upregulated the Bcl-2, beclin1, LC3, Nrf2, and HO-1 levels in this animal model.	Curcumin	13-21	heme oxygenase 1	Rattus norvegicus	159-163
33204708-15	2020	The results provide a scientific basis that curcumin could significantly alleviate the development of MN by inducing autophagy and alleviating renal oxidative stress through the PI3K/AKT/mTOR and Nrf2/HO-1 pathways.	Curcumin	44-52	mechanistic target of rapamycin kinase	Rattus norvegicus	187-191
33204708-15	2020	The results provide a scientific basis that curcumin could significantly alleviate the development of MN by inducing autophagy and alleviating renal oxidative stress through the PI3K/AKT/mTOR and Nrf2/HO-1 pathways.	Curcumin	44-52	heme oxygenase 1	Rattus norvegicus	201-205
33147541-1	2020	BACKGROUND: The present study was aimed to evaluate the nano-curcumin supplementation on Th1/Th17 balance by assessment of gene expression and serum level of interferon gamma (IFN-gamma) and interleukin-17 (IL-17) in migraine patients.	Curcumin	61-69	interleukin 17A	Homo sapiens	191-205
33147541-1	2020	BACKGROUND: The present study was aimed to evaluate the nano-curcumin supplementation on Th1/Th17 balance by assessment of gene expression and serum level of interferon gamma (IFN-gamma) and interleukin-17 (IL-17) in migraine patients.	Curcumin	61-69	interleukin 17A	Homo sapiens	207-212
29138815-0	2018	Curcumin reverses tobacco smoke-induced epithelial-mesenchymal transition by suppressing the MAPK pathway in the lungs of mice.	Curcumin	0-8	probable serine/threonine-protein kinase WNK4	Nicotiana tabacum	93-97
33147541-4	2020	RESULTS: Compared to placebo group, two month nano-curcumin supplementation led to a significant reduction in serum levels and expression of IL-17 mRNA (P = 0.006 & 0.04, respectively), while there was no statistical difference regarding serum levels and expression of IFN-gamma mRNA.	Curcumin	51-59	interleukin 17A	Homo sapiens	141-146
33147541-5	2020	CONCLUSION: Nano-curcumin supplementation in migraine patients led to a significant reduction in gene expression and plasma levels of IL-17 compared to control group.	Curcumin	17-25	interleukin 17A	Homo sapiens	134-139
33182071-0	2020	Curcumin may be a potential adjuvant treatment drug for colon cancer by targeting CD44.	Curcumin	0-8	CD44 molecule (Indian blood group)	Homo sapiens	82-86
33182071-4	2020	It has also been suggested that curcumin was effective against colon CSCs by coupling with CD44, a robust marker and functional important molecule for colorectal CSC.	Curcumin	32-40	CD44 molecule (Indian blood group)	Homo sapiens	91-95
33182071-6	2020	Results from real-time PCR and western blotting had suggested that curcumin could down-regulate the expression of CD44.	Curcumin	67-75	CD44 molecule (Indian blood group)	Homo sapiens	114-118
29138815-9	2018	Curcumin treatment inhibited tobacco smoke-induced MAPK/AP-1 activation, including ERK1/2, JNK and p38 MAPK pathways, and AP-1 proteins, and reversed EMT alterations in lung tissue.	Curcumin	0-8	probable serine/threonine-protein kinase WNK4	Nicotiana tabacum	51-55
33182071-7	2020	Moreover, results from flow cytometry had further revealed that curcumin could decrease the proportion of CD44+ colon cancer cells.	Curcumin	64-72	CD44 molecule (Indian blood group)	Homo sapiens	106-110
33182071-8	2020	After the expression of CD44 had been knocked down by using siRNA, the inhibition effects of curcumin against CD44+ colon cancer cells were observed to be reduced significantly.	Curcumin	93-101	CD44 molecule (Indian blood group)	Homo sapiens	24-28
29138815-9	2018	Curcumin treatment inhibited tobacco smoke-induced MAPK/AP-1 activation, including ERK1/2, JNK and p38 MAPK pathways, and AP-1 proteins, and reversed EMT alterations in lung tissue.	Curcumin	0-8	truncated transcription factor CAULIFLOWER A-like	Nicotiana tabacum	56-60
33182071-8	2020	After the expression of CD44 had been knocked down by using siRNA, the inhibition effects of curcumin against CD44+ colon cancer cells were observed to be reduced significantly.	Curcumin	93-101	CD44 molecule (Indian blood group)	Homo sapiens	110-114
33182071-9	2020	Moreover, it had been observed that the cellular uptake of curcumin was significantly higher in CD44+ colon cancer cells.	Curcumin	59-67	CD44 molecule (Indian blood group)	Homo sapiens	96-100
29138815-9	2018	Curcumin treatment inhibited tobacco smoke-induced MAPK/AP-1 activation, including ERK1/2, JNK and p38 MAPK pathways, and AP-1 proteins, and reversed EMT alterations in lung tissue.	Curcumin	0-8	probable serine/threonine-protein kinase WNK4	Nicotiana tabacum	103-107
33182071-10	2020	Results from flow cytometry had shown that curcumin could induce apoptosis in CD44+ colon cancer cells.	Curcumin	43-51	CD44 molecule (Indian blood group)	Homo sapiens	78-82
29138815-9	2018	Curcumin treatment inhibited tobacco smoke-induced MAPK/AP-1 activation, including ERK1/2, JNK and p38 MAPK pathways, and AP-1 proteins, and reversed EMT alterations in lung tissue.	Curcumin	0-8	truncated transcription factor CAULIFLOWER A-like	Nicotiana tabacum	122-126
33182071-11	2020	Altogether, our results suggested that curcumin might be an adjuvant drug for the treatment of colorectal cancer by targeting CD44.	Curcumin	39-47	CD44 molecule (Indian blood group)	Homo sapiens	126-130
29073609-6	2018	Both nano-curcumin and curcumin induced changes in proteasome-mediated proteolytic activity characterized by increased activity of the proteasome subunits beta2 and beta5i/beta1 and reduced activity of beta5/beta1i.	Curcumin	10-18	adaptor related protein complex 5 subunit beta 1	Homo sapiens	202-214
31983246-11	2020	In summary, Tq + Cur had protective effects on cisplatin-induced nephrotoxicity and renal injury, which could be mediated by up-regulation of survival signals like Akt, Nrf2/HO-1, and attenuation of KIM-1, NFkB.	Curcumin	17-20	hepatitis A virus cellular receptor 1	Homo sapiens	199-204
28980111-6	2017	In addition, Curcumin administration protects rats against acetamiprid-induced cerebellum toxicity such as increase in AChE and BChE activities, decrease on cells viability, oxidative stress, and an increase of intracellular calcium.	Curcumin	13-21	acetylcholinesterase	Rattus norvegicus	119-123
32735936-10	2020	In addition, oral administration of curcumin increased the expression of 15-PGDH and its regulators such as p-ERK1/2, p-JNK, and c-Jun in the mouse stomach.	Curcumin	36-44	mitogen-activated protein kinase 8	Mus musculus	120-123
33130987-9	2020	Autocrine GH-mediated IL-6, IL-8, IL-10 expressions were downregulated by curcumin treatment.	Curcumin	74-82	interleukin 10	Homo sapiens	34-39
32891672-5	2020	In addition, our results demonstrated that curcumin alone downregulates the hypoxia-induced expression of HIF-1, GFAP, and NF-H proteins in WMI, whereas riluzole alone and in combination with curcumin remained ineffective in changing the expression of these proteins.	Curcumin	43-51	glial fibrillary acidic protein	Homo sapiens	113-117
32891672-6	2020	Contrarily, after inhibiting Ca2+ influx with EGTA, riluzole alone and in combination with curcumin significantly downregulated hypoxia-induced expression of GFAP and NF-H.	Curcumin	91-99	glial fibrillary acidic protein	Homo sapiens	158-162
33178666-3	2020	Curcumin inhibits Bcl-2, Bcl-XL, VEGF, c-Myc, ICAM-1, EGFR, STAT3 phosphorylation, and cyclin D1 genes involved in the various stages of breast, prostate, and gastric cancer proliferation, angiogenesis, invasion, and metastasis.	Curcumin	0-8	intercellular adhesion molecule 1	Homo sapiens	46-52
32822714-0	2020	Effect of Atorvastatin, Curcumin, and Quercetin on miR-21 and miR-122 and their correlation with TGFbeta1 expression in experimental liver fibrosis.	Curcumin	24-32	microRNA 21	Rattus norvegicus	51-57
32822714-4	2020	In the present study, we investigate the effects of curcumin, quercetin, and atorvastatin on the expression levels of miR-21 and miR-122 and evaluated their correlation with TGFbeta1 expression in bile duct ligation (BDL)-induced fibrotic rats.	Curcumin	52-60	microRNA 21	Rattus norvegicus	118-124
29238464-0	2017	Curcumin enhances liver SIRT3 expression in the rat model of cirrhosis.	Curcumin	0-8	sirtuin 3	Rattus norvegicus	24-29
33335801-8	2021	Finally, a curcumin-induced increase in CELF2 expression resulted in increased ovarian cancer cell sensitivity to cisplatin.	Curcumin	11-19	CUGBP Elav-like family member 2	Homo sapiens	40-45
32535666-6	2020	Compared with the CLP group, the increased IL-35 expression in CLP with the curcumin pretreatment (CLP + Cur) group was consistent with the decreased severity of lung injury, IL-17A protein levels in lung tissue, and Treg-related cytokines levels.	Curcumin	76-84	interleukin 17A	Mus musculus	175-181
32535666-9	2020	In vitro, CD4+CD25+FOXP3+ Treg cells from naive CD4+ T cells, STAT5 proportion, and IL-35 expression increased after curcumin treatment.	Curcumin	117-125	CD4 antigen	Mus musculus	10-13
32535666-9	2020	In vitro, CD4+CD25+FOXP3+ Treg cells from naive CD4+ T cells, STAT5 proportion, and IL-35 expression increased after curcumin treatment.	Curcumin	117-125	interleukin 2 receptor, alpha chain	Mus musculus	14-18
32535666-9	2020	In vitro, CD4+CD25+FOXP3+ Treg cells from naive CD4+ T cells, STAT5 proportion, and IL-35 expression increased after curcumin treatment.	Curcumin	117-125	CD4 antigen	Mus musculus	48-51
29238464-6	2017	Results: It was identified that SIRT3, AMPK, CPT-1A, IDH2 and MnSOD expression significantly decreased in BDL rats compared to sham rats; however, in the curcumin treatment of BDL rats, the expression of these factors increased significantly compared to BDL (P&lt;0.05).	Curcumin	154-162	sirtuin 3	Rattus norvegicus	32-37
32399774-6	2020	Protein expressions of MMP-2, MMP-9 and VEGF in the WERI-Rb-1 cells were also significantly inhibited by curcumin in a concentration-dependent manner (0-40 microM).	Curcumin	105-113	matrix metallopeptidase 9	Homo sapiens	30-35
29238464-6	2017	Results: It was identified that SIRT3, AMPK, CPT-1A, IDH2 and MnSOD expression significantly decreased in BDL rats compared to sham rats; however, in the curcumin treatment of BDL rats, the expression of these factors increased significantly compared to BDL (P&lt;0.05).	Curcumin	154-162	carnitine palmitoyltransferase 1A	Rattus norvegicus	45-51
32399774-8	2020	CONCLUSION: Curcumin inhibited proliferation and migration of WERI-Rb-1 cells, a cell line of human retinoblastoma, which might be through modulating NF-kappaB and its downstream proteins including VEGF, MMP-2, and MMP-9.	Curcumin	12-20	matrix metallopeptidase 9	Homo sapiens	215-220
29238464-6	2017	Results: It was identified that SIRT3, AMPK, CPT-1A, IDH2 and MnSOD expression significantly decreased in BDL rats compared to sham rats; however, in the curcumin treatment of BDL rats, the expression of these factors increased significantly compared to BDL (P&lt;0.05).	Curcumin	154-162	isocitrate dehydrogenase (NADP(+)) 2	Rattus norvegicus	53-57
32814232-8	2020	RESULTS: We found that punicalagin and curcumin significantly supressed TNF-induced pro-inflammatory cytokine (IL1A, IL1B, and IL6) and chemokine (CCL2-4, CXCL1, CXCL5 and CXCL8) expression in human placenta, VAT and SAT.	Curcumin	39-47	C-X-C motif chemokine ligand 1	Homo sapiens	155-160
32814232-8	2020	RESULTS: We found that punicalagin and curcumin significantly supressed TNF-induced pro-inflammatory cytokine (IL1A, IL1B, and IL6) and chemokine (CCL2-4, CXCL1, CXCL5 and CXCL8) expression in human placenta, VAT and SAT.	Curcumin	39-47	C-X-C motif chemokine ligand 5	Homo sapiens	162-167
29238464-8	2017	Conclusion: Curcumin reduced liver damage and oxidative stress in the liver tissue of BDL rats through up-regulation of SIRT3, AMPK, CPT-1A, IDH2 and MnSOD as well as changing the level of serum lipid profile.	Curcumin	12-20	sirtuin 3	Rattus norvegicus	120-125
32718261-0	2020	Combination of pomegranate extract and curcumin ameliorates thioacetamide-induced liver fibrosis in rats: Impact on TGF-beta/Smad3 and NF-kappaB signaling pathways.	Curcumin	39-47	transforming growth factor alpha	Rattus norvegicus	116-124
29238464-8	2017	Conclusion: Curcumin reduced liver damage and oxidative stress in the liver tissue of BDL rats through up-regulation of SIRT3, AMPK, CPT-1A, IDH2 and MnSOD as well as changing the level of serum lipid profile.	Curcumin	12-20	carnitine palmitoyltransferase 1A	Rattus norvegicus	133-139
32718261-5	2020	The results indicated that PE and/or curcumin attenuated TAA-induced liver fibrogenesis, as evidenced by significant improvement in the liver function tests (AST, ALT, ALP, and albumin), oxidative stress biomarkers (MDA, SOD, and GSH), and inflammatory biomarkers (NF-kB, TNF-alpha, IL-1beta, iNOS, TGF-beta, and MPO), compared to TAA group.	Curcumin	37-45	PDZ and LIM domain 3	Rattus norvegicus	168-171
32718261-5	2020	The results indicated that PE and/or curcumin attenuated TAA-induced liver fibrogenesis, as evidenced by significant improvement in the liver function tests (AST, ALT, ALP, and albumin), oxidative stress biomarkers (MDA, SOD, and GSH), and inflammatory biomarkers (NF-kB, TNF-alpha, IL-1beta, iNOS, TGF-beta, and MPO), compared to TAA group.	Curcumin	37-45	albumin	Rattus norvegicus	177-184
29238464-8	2017	Conclusion: Curcumin reduced liver damage and oxidative stress in the liver tissue of BDL rats through up-regulation of SIRT3, AMPK, CPT-1A, IDH2 and MnSOD as well as changing the level of serum lipid profile.	Curcumin	12-20	isocitrate dehydrogenase (NADP(+)) 2	Rattus norvegicus	141-145
32718261-5	2020	The results indicated that PE and/or curcumin attenuated TAA-induced liver fibrogenesis, as evidenced by significant improvement in the liver function tests (AST, ALT, ALP, and albumin), oxidative stress biomarkers (MDA, SOD, and GSH), and inflammatory biomarkers (NF-kB, TNF-alpha, IL-1beta, iNOS, TGF-beta, and MPO), compared to TAA group.	Curcumin	37-45	transforming growth factor alpha	Rattus norvegicus	299-307
27927067-0	2017	Curcumin suppresses inflammatory cytokines and heat shock protein 70 release and improves metabolic parameters during experimental sepsis.	Curcumin	0-8	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	47-68
33073093-0	2020	Curcumin Allosterically Inhibits the Dengue NS2B-NS3 Protease by Disrupting Its Active Conformation.	Curcumin	0-8	KRAS proto-oncogene, GTPase	Homo sapiens	49-52
29052674-0	2017	EGFR-targeting PLGA-PEG nanoparticles as a curcumin delivery system for breast cancer therapy.	Curcumin	43-51	epidermal growth factor receptor	Mus musculus	0-4
32776418-0	2020	Curcumin reinforces MSC-derived exosomes in attenuating osteoarthritis via modulating the miR-124/NF-kB and miR-143/ROCK1/TLR9 signalling pathways.	Curcumin	0-8	toll-like receptor 9	Mus musculus	122-126
32009245-8	2020	Further, in vitro curcumin intervention inhibited M1-type polarization via the Janus kinase1/2-signal transducer and activator of transcription protein1 (JAK1/2-STAT1) pathway.	Curcumin	18-26	signal transducer and activator of transcription 1	Mus musculus	161-166
32009245-10	2020	Curcumin prevents inflammatory-mediated apoptosis of osteocytes in part through inhibition of M1 polarization through the JAK1/2-STAT1 pathway.	Curcumin	0-8	signal transducer and activator of transcription 1	Mus musculus	129-134
29052674-5	2017	Treatment of breast cancer cells and tumor-bearing mice with these curcumin-loaded nanoparticles gave rise to reduced phosphoinositide 3-kinase signaling, decreased cancer cell viability, attenuated drug clearance from the circulation, and suppressed tumor burden compared with free curcumin or non-EGFR targeting nanoparticles.	Curcumin	67-75	epidermal growth factor receptor	Mus musculus	299-303
32603817-13	2020	SIGNIFICANCE: The current study reveals the protective effects of Curcumin and LOXblock-1 on acute kidney injury by suppressing SEMA3A as a new biomarker.	Curcumin	66-74	semaphorin 3A	Rattus norvegicus	128-134
29067098-1	2017	The aim of the present study was to observe the dynamic changes of the growth arrest and DNA damage-inducible 153 (GADD153) gene and caspase-12 in the brain tissue of rats with cerebral ischemia-reperfusion injury (CIRI) and the impact of curcumin pretreatment.	Curcumin	239-247	DNA-damage inducible transcript 3	Rattus norvegicus	115-122
28736282-9	2017	Apart from this, curcumin significantly enhanced the skin-barrier function by up-regulation of involucrin (iNV) and filaggrin (FLG), the regulators of epidermal skin barrier.	Curcumin	17-25	filaggrin	Homo sapiens	116-125
32848804-8	2020	This review will examine compounds of natural origin recently found to upregulate SIRT1 activity, such as polyphenolic products in fruits, vegetables, and plants including resveratrol, fisetin, quercetin, and curcumin.	Curcumin	209-217	sirtuin 1	Homo sapiens	82-87
31972207-0	2020	Curcumin reduces LPS-induced septic acute kidney injury through suppression of lncRNA PVT1 in mice.	Curcumin	0-8	Pvt1 oncogene	Mus musculus	86-90
28736282-9	2017	Apart from this, curcumin significantly enhanced the skin-barrier function by up-regulation of involucrin (iNV) and filaggrin (FLG), the regulators of epidermal skin barrier.	Curcumin	17-25	filaggrin	Homo sapiens	127-130
31972207-7	2020	Moreover, NRK cells that overexpressed PVT1 had lower survival rates than WT NRK cells obtained from mice that received curcumin treatment after treating with LPS.	Curcumin	120-128	Pvt1 oncogene	Mus musculus	39-43
28843521-0	2017	Curcumin suppresses proliferation and in vitro invasion of human prostate cancer stem cells by ceRNA effect of miR-145 and lncRNA-ROR.	Curcumin	0-8	microRNA 145	Homo sapiens	111-118
31972207-8	2020	Additionally, curcumin reduced the LPS-induced increase in Bax, cleaved-caspase3/caspase 3, p-IkBalpha/IkBalpha, p-p65/p65, p-JNK/JNK, and p-c-JUN/c-JUN protein expression, and increased Bcl2 protein expression in NRK cells.	Curcumin	14-22	BCL2-associated X protein	Mus musculus	59-62
31972207-8	2020	Additionally, curcumin reduced the LPS-induced increase in Bax, cleaved-caspase3/caspase 3, p-IkBalpha/IkBalpha, p-p65/p65, p-JNK/JNK, and p-c-JUN/c-JUN protein expression, and increased Bcl2 protein expression in NRK cells.	Curcumin	14-22	caspase 3	Mus musculus	81-90
31972207-8	2020	Additionally, curcumin reduced the LPS-induced increase in Bax, cleaved-caspase3/caspase 3, p-IkBalpha/IkBalpha, p-p65/p65, p-JNK/JNK, and p-c-JUN/c-JUN protein expression, and increased Bcl2 protein expression in NRK cells.	Curcumin	14-22	mitogen-activated protein kinase 8	Mus musculus	126-129
28843521-4	2017	The expression levels of cell cycle proteins (Ccnd1 and Cdk4) and stem cell markers (Oct4, CD44, and CD133) were decreased in curcumin-treated HuPCaSCs.	Curcumin	126-134	POU class 5 homeobox 1	Homo sapiens	85-89
31972207-8	2020	Additionally, curcumin reduced the LPS-induced increase in Bax, cleaved-caspase3/caspase 3, p-IkBalpha/IkBalpha, p-p65/p65, p-JNK/JNK, and p-c-JUN/c-JUN protein expression, and increased Bcl2 protein expression in NRK cells.	Curcumin	14-22	mitogen-activated protein kinase 8	Mus musculus	130-133
31972207-10	2020	CONCLUSION: Curcumin decreased PVT1 expression in LPS-induced septic acute kidney tissues and reduced LPS-induced septic acute kidney injury in mice.	Curcumin	12-20	Pvt1 oncogene	Mus musculus	31-35
28843521-5	2017	Microarray analysis and northern blotting assays indicated that miR-145 was overexpressed in curcumin-treated HuPCaSCs.	Curcumin	93-101	microRNA 145	Homo sapiens	64-71
31972207-11	2020	This might be related to the inhibition of the JNK/NF-kappaB pathway by curcumin through suppression of lncRNA PVT1.	Curcumin	72-80	mitogen-activated protein kinase 8	Mus musculus	47-50
31972207-11	2020	This might be related to the inhibition of the JNK/NF-kappaB pathway by curcumin through suppression of lncRNA PVT1.	Curcumin	72-80	Pvt1 oncogene	Mus musculus	111-115
28843521-7	2017	Curcumin induced high miR-145 expression and inhibited the expression of lncRNA-ROR.	Curcumin	0-8	microRNA 145	Homo sapiens	22-29
28843521-11	2017	Thus, curcumin suppresses the proliferation, in vitro invasion, and tumorigenicity of HuPCaSCs through ceRNA effect of miR-145 and lncRNA-ROR caused.	Curcumin	6-14	microRNA 145	Homo sapiens	119-126
28719859-0	2017	"Curcumin-loaded Poly (d, l-lactide-co-glycolide) nanovesicles induce antinociceptive effects and reduce pronociceptive cytokine and BDNF release in spinal cord after acute administration in mice".	Curcumin	1-9	brain derived neurotrophic factor	Mus musculus	133-137
32848737-8	2020	For instance, ethosomes and microneedle delivery system such as curcumin-loaded HA-modified ethosomes were developed to enhance skin retention and delivery of curcumin to CD44-expressing psoriatic cells whereas methotrexate-loaded HA-based microneedle was shown to enhance skin penetration of methotrexate to alleviate psoriasis-like skin inflammation.	Curcumin	64-72	CD44 molecule (Indian blood group)	Homo sapiens	171-175
32848737-8	2020	For instance, ethosomes and microneedle delivery system such as curcumin-loaded HA-modified ethosomes were developed to enhance skin retention and delivery of curcumin to CD44-expressing psoriatic cells whereas methotrexate-loaded HA-based microneedle was shown to enhance skin penetration of methotrexate to alleviate psoriasis-like skin inflammation.	Curcumin	159-167	CD44 molecule (Indian blood group)	Homo sapiens	171-175
32724322-0	2020	Curcumin Inhibits Hepatocellular Carcinoma via Regulating miR-21/TIMP3 Axis.	Curcumin	0-8	TIMP metallopeptidase inhibitor 3	Homo sapiens	65-70
32724322-8	2020	Meanwhile, the curcumin treatment can downregulate miR-21 expression, upregulate TIMP3 expression, and inhibit the TGF-beta1/smad3 signaling pathway.	Curcumin	15-23	TIMP metallopeptidase inhibitor 3	Homo sapiens	81-86
32724322-11	2020	Interestingly, the effect of miR-21 inhibition on cell proliferation, apoptosis, and TGF-beta1/smad3 signaling pathway in HepG2 and HCCLM3 cells exposed to curcumin was attenuated by TIMP3 silencing.	Curcumin	156-164	TIMP metallopeptidase inhibitor 3	Homo sapiens	183-188
28608236-14	2017	In contrast, various doses of curcumin attenuated nicotine-induced apoptosis, oxidative stress and inflammation; while elevating P-CREB and BDNF levels.	Curcumin	30-38	cAMP responsive element binding protein 1	Rattus norvegicus	131-135
32724322-12	2020	Conclusion: Taken together, the present study suggests that miR-21 is involved in the anticancer activities of curcumin through targeting TIMP3, and the mechanism possibly refers to the inhibition of TGF-beta1/smad3 signaling pathway.	Curcumin	111-119	TIMP metallopeptidase inhibitor 3	Homo sapiens	138-143
32485495-9	2020	Further experiments showed that curcumin can upregulate the Nrf2-Keap1 signaling pathway at the transcriptional level, and this upregulation can induce downstream defense genes, including glutamate cysteine ligase catalytic subunit(GCLC) and glutamate cysteine ligase modifier subunit (GCLM), and thereby promote GSH synthesis and the expression of related antioxidases.	Curcumin	32-40	glutamate--cysteine ligase regulatory subunit	Oreochromis niloticus	242-284
32485495-9	2020	Further experiments showed that curcumin can upregulate the Nrf2-Keap1 signaling pathway at the transcriptional level, and this upregulation can induce downstream defense genes, including glutamate cysteine ligase catalytic subunit(GCLC) and glutamate cysteine ligase modifier subunit (GCLM), and thereby promote GSH synthesis and the expression of related antioxidases.	Curcumin	32-40	glutamate--cysteine ligase regulatory subunit	Oreochromis niloticus	286-290
31654258-8	2020	In addition, CUR and/or Se reduced serum C-reactive protein, liver pro-inflammatory cytokines, and the expression of TLR4, NF-kappaB, JNK, and p38, and upregulated heme oxygenase-1 (HO-1).	Curcumin	13-16	heme oxygenase 1	Rattus norvegicus	164-180
28608236-15	2017	Thus, curcumin via activation of P-CREB/BDNF signaling pathway, confers neuroprotection against nicotine-induced inflammation, apoptosis and oxidative stress.	Curcumin	6-14	cAMP responsive element binding protein 1	Rattus norvegicus	35-39
31654258-8	2020	In addition, CUR and/or Se reduced serum C-reactive protein, liver pro-inflammatory cytokines, and the expression of TLR4, NF-kappaB, JNK, and p38, and upregulated heme oxygenase-1 (HO-1).	Curcumin	13-16	heme oxygenase 1	Rattus norvegicus	182-186
29085504-2	2017	The aim of the present study was to investigate whether curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer through Bcl-2 and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), and by upregulating microRNA-15a (miR-15a).	Curcumin	56-64	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	154-179
32377752-16	2020	In addition, curcumin and IL-6-neutralizing antibody treatment suppressed PSC-CM-modulated pancreatic cancer invasion, EMT and the changes in the expression of E-cadherin, vimentin and matrix metallopeptidase-9.	Curcumin	13-21	matrix metallopeptidase 9	Homo sapiens	185-210
28952709-0	2017	OPN b and c Isoforms Doubtless Veto Anti-angiogenesis Effects of Curcumin in Combination with Conventional AML Regiment Osteopontin (OPN) is an extracellular structural protein that is secreted by osteoblasts and hematopoietic cells.It suppresses the proliferation of hematopoietic stem and also plays an important role in promoting survival anddrug resistance in leukemic stem cells (LSCs).	Curcumin	65-73	secreted phosphoprotein 1	Homo sapiens	0-3
32113849-0	2020	alpha-Synuclein fibrillation products trigger the release of hexokinase I from mitochondria: Protection by curcumin, and possible role in pathogenesis of Parkinson"s disease.	Curcumin	107-115	synuclein alpha	Rattus norvegicus	0-15
32113849-7	2020	Moreover, we found that curcumin was very effective in preventing mitochondrial HKI release and ROS enhancement induced by alpha-synuclein fibrillation products.	Curcumin	24-32	synuclein alpha	Rattus norvegicus	123-138
28952709-0	2017	OPN b and c Isoforms Doubtless Veto Anti-angiogenesis Effects of Curcumin in Combination with Conventional AML Regiment Osteopontin (OPN) is an extracellular structural protein that is secreted by osteoblasts and hematopoietic cells.It suppresses the proliferation of hematopoietic stem and also plays an important role in promoting survival anddrug resistance in leukemic stem cells (LSCs).	Curcumin	65-73	secreted phosphoprotein 1	Homo sapiens	120-131
28952709-0	2017	OPN b and c Isoforms Doubtless Veto Anti-angiogenesis Effects of Curcumin in Combination with Conventional AML Regiment Osteopontin (OPN) is an extracellular structural protein that is secreted by osteoblasts and hematopoietic cells.It suppresses the proliferation of hematopoietic stem and also plays an important role in promoting survival anddrug resistance in leukemic stem cells (LSCs).	Curcumin	65-73	secreted phosphoprotein 1	Homo sapiens	133-136
32325281-0	2020	Curcumin circumvent Lactate-induced Chemoresistance in Hepatic cancer cells through modulation of Hydroxycarboxylic acid receptor-1.	Curcumin	0-8	hydroxycarboxylic acid receptor 1	Homo sapiens	98-131
28952709-1	2017	Since the role of OPN isoforms in AML angiogenesis are remainingcontroversial, in the present study, we aimed to evaluate whether curcumin (CUR), as a known natural componentwith anti-angiogenesis effects, in a combination of AML conventional regiment has the potency to preclude inducedanti-angiogenesis effects of OPN isoforms or not?	Curcumin	130-138	secreted phosphoprotein 1	Homo sapiens	18-21
32325281-6	2020	Curcumin also diminished the lactate-induced chemoresistance against doxorubicin in hepatic cancer cells along with down regulation of lactate receptor (hydroxycarboxylic acid receptor-1; HCAR-1/GPR81).	Curcumin	0-8	hydroxycarboxylic acid receptor 1	Homo sapiens	153-186
32325281-6	2020	Curcumin also diminished the lactate-induced chemoresistance against doxorubicin in hepatic cancer cells along with down regulation of lactate receptor (hydroxycarboxylic acid receptor-1; HCAR-1/GPR81).	Curcumin	0-8	hydroxycarboxylic acid receptor 1	Homo sapiens	188-194
28535906-7	2017	Hence, in the present study we explore whether curcumin inhibits NEDD4, resulting in the suppression of cell growth, migration and invasion in PC cells.	Curcumin	47-55	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	65-70
32325281-6	2020	Curcumin also diminished the lactate-induced chemoresistance against doxorubicin in hepatic cancer cells along with down regulation of lactate receptor (hydroxycarboxylic acid receptor-1; HCAR-1/GPR81).	Curcumin	0-8	hydroxycarboxylic acid receptor 1	Homo sapiens	195-200
32596292-7	2020	There were significant decrements in IL-1beta, IL-6, and TNFalpha expression in both curcumin and Cur-CS nanoparticles.	Curcumin	85-93	interleukin 6	Felis catus	47-51
28535906-8	2017	We found that curcumin inhibited cell proliferation and triggered apoptosis in PC, which is associated with increased expression of PTEN and p73.	Curcumin	14-22	phosphatase and tensin homolog	Homo sapiens	132-136
28535906-9	2017	These results suggested that inhibition of NEDD4 might be beneficial to the antitumor properties of curcumin on PC treatments.	Curcumin	100-108	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	43-48
28883651-5	2017	Treatment with curcumin and inhibitors of HDACs, or infection with RSV prevented expression of p63 with an increase of claudin-4 and the number of microvilli.	Curcumin	15-23	tumor protein p63	Homo sapiens	95-98
32534511-8	2020	The levels of IL-6, IL-17, and IFN-gamma, as well as FBS, was significantly decreased in the treated group with curcumin compared to the diabetic group mice (p<0.05).	Curcumin	112-120	interleukin 17A	Mus musculus	20-25
28677733-10	2017	Importantly, the IFN-gamma-induced increase in the expression levels of MIG, IP-10 and I-TAC in the INS-1 cells was strongly inhibited by SFN, but not by other natural substances, such as curcumin, sanguinarine, resveratrol, triptolide and epigallocatechin gallate (EGCG), suggesting the specificity of SFN in downregulating the levels of these chemokines.	Curcumin	188-196	interferon gamma	Rattus norvegicus	17-26
32147428-7	2020	Furthermore, curcumin treatment following administration of the DHEA resulted in a significant decrease in BAX (p < 0.001) and levels of expression of Caspase3 (CASP3) protein, increased levels of B-cell lymphoma 2 (Bcl2) expression (p < 0.05), and moderated apoptosis in granulosa cells in comparison with the ones seen in the PCOS group.	Curcumin	13-21	BCL2-associated X protein	Mus musculus	107-110
32147428-7	2020	Furthermore, curcumin treatment following administration of the DHEA resulted in a significant decrease in BAX (p < 0.001) and levels of expression of Caspase3 (CASP3) protein, increased levels of B-cell lymphoma 2 (Bcl2) expression (p < 0.05), and moderated apoptosis in granulosa cells in comparison with the ones seen in the PCOS group.	Curcumin	13-21	caspase 3	Mus musculus	151-159
32147428-7	2020	Furthermore, curcumin treatment following administration of the DHEA resulted in a significant decrease in BAX (p < 0.001) and levels of expression of Caspase3 (CASP3) protein, increased levels of B-cell lymphoma 2 (Bcl2) expression (p < 0.05), and moderated apoptosis in granulosa cells in comparison with the ones seen in the PCOS group.	Curcumin	13-21	caspase 3	Mus musculus	161-166
33447259-4	2020	The present study was a clinical trial for investigating the effects of curcumin on activity and gene expression of MMP-2 and MMP-9 in patients with CAD.	Curcumin	72-80	matrix metallopeptidase 9	Homo sapiens	126-131
33447259-10	2020	RESULTS: After 3 months of medication, the expression of MMP-9 produced by PBMCs significantly decreased in the curcumin group (0.811 +- 0.25) in comparison with the placebo group (2.23 +- 0.94) (P < 0.0001).	Curcumin	112-120	matrix metallopeptidase 9	Homo sapiens	57-62
33447259-11	2020	Furthermore, the zymographic analysis showed that the administration of curcumin significantly inhibited the activity levels of MMP-2 (12469.7 +- 5308.64 pixels) and MMP-9 (14007.2 +- 5371.67 pixels) in comparison with that in patients receiving placebo (MMP-2: 17613.8 +- 5250.68 pixels; MMP-9: 20010.1 +- 3259.37 pixels) (P < 0.0500).	Curcumin	72-80	matrix metallopeptidase 9	Homo sapiens	166-171
28894373-0	2017	Curcumin inhibits apoptosis by modulating Bax/Bcl-2 expression and alleviates oxidative stress in testes of streptozotocin-induced diabetic rats.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	42-45
33447259-11	2020	Furthermore, the zymographic analysis showed that the administration of curcumin significantly inhibited the activity levels of MMP-2 (12469.7 +- 5308.64 pixels) and MMP-9 (14007.2 +- 5371.67 pixels) in comparison with that in patients receiving placebo (MMP-2: 17613.8 +- 5250.68 pixels; MMP-9: 20010.1 +- 3259.37 pixels) (P < 0.0500).	Curcumin	72-80	matrix metallopeptidase 9	Homo sapiens	289-294
33447259-12	2020	CONCLUSION: Our results show that curcumin can significantly reduce the expression and activity of MMP-2 and MMP-9.	Curcumin	34-42	matrix metallopeptidase 9	Homo sapiens	109-114
28894373-7	2017	Molecular analysis demonstrated that curcumin treatment significantly and simultaneously decreased Bax and increased Bcl-2 expressions, therefore elevating the ratio of Bcl-2/Bax.	Curcumin	37-45	BCL2 associated X, apoptosis regulator	Rattus norvegicus	99-102
28894373-7	2017	Molecular analysis demonstrated that curcumin treatment significantly and simultaneously decreased Bax and increased Bcl-2 expressions, therefore elevating the ratio of Bcl-2/Bax.	Curcumin	37-45	BCL2 associated X, apoptosis regulator	Rattus norvegicus	175-178
28894373-10	2017	The capability of curcumin in inhibiting oxidative stress and modulating the Bax/Bcl-2-mediated cell death pathway reveals its potential as a therapeutic agent against diabetes.	Curcumin	18-26	BCL2 associated X, apoptosis regulator	Rattus norvegicus	77-80
31952056-0	2020	GANT61 and Curcumin loaded PLGA Nanoparticles for GLI-1 and PI3K/Akt Mediated Inhibition in Breast Adenocarcinoma.	Curcumin	11-19	GLI family zinc finger 1	Homo sapiens	50-55
29245915-10	2017	Multiplex analyses of plasma taken after drug exposure at animal nadir indicated that the levels of M-CSF, CXCL-9, PDGF and G-CSF were significantly increased by [curcumin + sildenafil] and that expression of CXCL1 and CCL5 were significantly reduced.	Curcumin	163-171	colony stimulating factor 1	Homo sapiens	100-105
32037797-7	2020	Curcumin supplementation at 200 mg/kg up-regulated the levels of AKT, NGF, mTOR, Nrf2 and HO-1 mRNA, and concomitantly down-regulated Bax, caspases-3 and -9 mRNA; it also decreased caspase-3 and caspase-9 activity.	Curcumin	0-8	caspase 3	Mus musculus	139-156
32037797-7	2020	Curcumin supplementation at 200 mg/kg up-regulated the levels of AKT, NGF, mTOR, Nrf2 and HO-1 mRNA, and concomitantly down-regulated Bax, caspases-3 and -9 mRNA; it also decreased caspase-3 and caspase-9 activity.	Curcumin	0-8	caspase 3	Mus musculus	181-190
29245915-10	2017	Multiplex analyses of plasma taken after drug exposure at animal nadir indicated that the levels of M-CSF, CXCL-9, PDGF and G-CSF were significantly increased by [curcumin + sildenafil] and that expression of CXCL1 and CCL5 were significantly reduced.	Curcumin	163-171	colony stimulating factor 3	Homo sapiens	124-129
28948066-8	2017	Curcumin treatment reduced the expression of p53, caspase-3, and bax/bxl-2 ratio significantly.	Curcumin	0-8	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	45-48
28948066-8	2017	Curcumin treatment reduced the expression of p53, caspase-3, and bax/bxl-2 ratio significantly.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	65-68
28627598-0	2017	Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells.	Curcumin	0-8	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	65-70
32256716-13	2020	In addition, the results of the present study suggested that nano-curcumin supplementation significantly increases serum concentrations of BDNF, IL-10, and total antioxidant capacity (TAC) in subjects with metabolic syndrome.	Curcumin	66-74	brain derived neurotrophic factor	Homo sapiens	139-143
32256716-13	2020	In addition, the results of the present study suggested that nano-curcumin supplementation significantly increases serum concentrations of BDNF, IL-10, and total antioxidant capacity (TAC) in subjects with metabolic syndrome.	Curcumin	66-74	interleukin 10	Homo sapiens	145-150
28627598-6	2017	However, whether curcumin regulates NEDD4 expression has not been described in human cancers.	Curcumin	17-25	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	36-41
28627598-8	2017	We further investigated whether curcumin exerts its antitumor activities via suppressing NEDD4 expression.	Curcumin	32-40	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	89-94
32006622-6	2020	The anti-psoriatic efficacy of Cur-GA-silica was confirmed by Psoriasis Area and Severity Index (PASI) evaluation, histological evaluation and decreased IL-17A in the imiquimod-induced psoriasiform mouse skin analyzed by enzyme-linked immunosorbent assay.	Curcumin	31-34	interleukin 17A	Mus musculus	153-159
28627598-9	2017	We found that curcumin reduced the expression of NEDD4 and Notch1 and pAKT, leading to glioma cell growth inhibition, apoptosis, and suppression of migration and invasion.	Curcumin	14-22	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	49-54
28627598-10	2017	Moreover, deletion of NEDD4 expression enhanced the sensitivity of glioma cells to curcumin treatment.	Curcumin	83-91	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	22-27
28627598-11	2017	Thus, inactivation of NEDD4 by curcumin could be a promising approach for therapeutic intervention.	Curcumin	31-39	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	22-27
31952595-3	2020	Then, we combined curcumin (Cur) with HASF into nano-micelles (HASF@Cur micelles) by self-assembling method.	Curcumin	18-26	divergent protein kinase domain 2A	Mus musculus	63-67
28286973-5	2017	Moreover, introduction of constitutively active AKT1 abolished the inhibitory effect of curcumin on cell proliferation, migration, and restored the phosphorylation levels of 4E-BP1 and S6K1, suggesting that curcumin functions via suppressing IGF2-mediated AKT/mTOR signaling pathway.	Curcumin	207-215	ribosomal protein S6 kinase B1	Homo sapiens	185-189
31991125-9	2020	Inhibition of CSN5 kinase activity by curcumin decreased HK2 protein expression and glycolysis, repressed the metastasis of HCC cells in vitro and in vivo, and prolonged the survival time of tumor-bearing nude mice.	Curcumin	38-46	COP9 signalosome subunit 5	Mus musculus	14-18
31545905-10	2020	In MCF-7 cells, separate or combined incubations with somatostatin and quercetin, significantly decreased EGFR and incubation with curcumin decreased MAPK signaling.	Curcumin	131-139	somatostatin	Homo sapiens	54-66
31612257-9	2020	Cisplatin-activated Hh signaling which was blocked by both Ars and curcumin as demonstrated by decreased mRNA levels of Shh, Smo, and Ptch and suppressed renal Gli1 and Gli2 protein levels.	Curcumin	67-75	sonic hedgehog signaling molecule	Rattus norvegicus	120-123
31612257-9	2020	Cisplatin-activated Hh signaling which was blocked by both Ars and curcumin as demonstrated by decreased mRNA levels of Shh, Smo, and Ptch and suppressed renal Gli1 and Gli2 protein levels.	Curcumin	67-75	GLI family zinc finger 2	Rattus norvegicus	169-173
28286973-5	2017	Moreover, introduction of constitutively active AKT1 abolished the inhibitory effect of curcumin on cell proliferation, migration, and restored the phosphorylation levels of 4E-BP1 and S6K1, suggesting that curcumin functions via suppressing IGF2-mediated AKT/mTOR signaling pathway.	Curcumin	207-215	insulin like growth factor 2	Homo sapiens	242-246
32175381-0	2020	Protective effects of curcumin against neuroinflammation induced by Abeta25-35 in primary rat microglia: modulation of high-mobility group box 1, toll-like receptor 4 and receptor for advanced glycation end products expression.	Curcumin	22-30	high mobility group box 1	Rattus norvegicus	119-144
28286973-6	2017	In summary, our results reveal that suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway is one of the mechanisms of action of curcumin.	Curcumin	141-149	insulin like growth factor 2	Homo sapiens	48-52
32175381-11	2020	Results: Curcumin was found to significantly inhibit HMGB1 expression and release in Abeta25-35-stimulated microglia.	Curcumin	9-17	high mobility group box 1	Rattus norvegicus	53-58
28286973-6	2017	In summary, our results reveal that suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway is one of the mechanisms of action of curcumin.	Curcumin	141-149	insulin like growth factor 2	Homo sapiens	57-61
32175381-15	2020	Conclusions: Curcumin effectively inhibits Abeta25-35-induced neuroinflammation in microglia, partly by suppressing the expression of HMGB1, TLR4, and RAGE.	Curcumin	13-21	high mobility group box 1	Rattus norvegicus	134-139
28286973-7	2017	Our findings suggest a new therapeutic strategy against human bladder cancer caused by aberrant activation of IGF2, which are useful for translational application of curcumin.	Curcumin	166-174	insulin like growth factor 2	Homo sapiens	110-114
28391715-3	2017	In this study, we firstly assessed how curcumin affects the expression of miR-143/miR-145 cluster.	Curcumin	39-47	microRNA 145	Homo sapiens	82-89
32172947-6	2020	Although the level of LC3 was lower, that of curcumin-induced LC3 was higher, in A172 cells than in U87MG cells.	Curcumin	45-53	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	62-65
28391715-5	2017	Our data showed that PC3, DU145 and LNCaP cells treated with curcumin had significantly restored miR-143 and miR-145 expression.	Curcumin	61-69	proprotein convertase subtilisin/kexin type 1	Homo sapiens	21-24
28391715-5	2017	Our data showed that PC3, DU145 and LNCaP cells treated with curcumin had significantly restored miR-143 and miR-145 expression.	Curcumin	61-69	microRNA 145	Homo sapiens	109-116
31816386-12	2020	Taken together, these results unveil that curcumin ameliorates oxidative stress, enhances intestinal barrier function and mitochondrial function via the induction of Parkin dependent mitophagy through AMPK activation and subsequent TFEB nuclear translocation.	Curcumin	42-50	parkin RBR E3 ubiquitin protein ligase	Sus scrofa	166-172
28391715-7	2017	In addition, curcumin treatment reduced the expression of DNMT1 and DNMT3B, which contribute to promoter hypermethylation of the miR-143/miR-145 cluster.	Curcumin	13-21	DNA methyltransferase 3 beta	Homo sapiens	68-74
32036964-14	2020	The curcumin group had the lowest expression of FAS and PPARG mRNA (P &lt; 0.05) and the highest expression of NRF2 and HMOX1 mRNA.	Curcumin	4-12	peroxisome proliferator-activated receptor gamma	Anas platyrhynchos	56-61
28391715-7	2017	In addition, curcumin treatment reduced the expression of DNMT1 and DNMT3B, which contribute to promoter hypermethylation of the miR-143/miR-145 cluster.	Curcumin	13-21	microRNA 145	Homo sapiens	137-144
28391715-8	2017	Therefore, we infer that curcumin can restore miR-143 and miR-145 expression via hypomethylation.	Curcumin	25-33	microRNA 145	Homo sapiens	58-65
28391715-10	2017	MiR-143 and curcumin remarkably reduced radiation-induced autophagy in PC3 and DU145 cells.	Curcumin	12-20	proprotein convertase subtilisin/kexin type 1	Homo sapiens	71-74
28429187-9	2017	Moreover, curcumin increased the hepatic glycogen content by inhibiting glycogen synthase kinase (GSK)-3beta and prevented gluconeogenesis by inhibiting phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase).	Curcumin	10-18	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	199-220
31971911-4	2020	The aim of this study was to use the curcumin analogue synthetic products (AKS-k and AKS-m) from cullilawan oil in male mice (Mus musculus L.) liver damage treatment induced by carbon tetrachloride (CCl4).	Curcumin	37-45	chemokine (C-C motif) ligand 4	Mus musculus	199-203
32673649-10	2020	RESULTS AND CONCLUSIONS: Curcumin reduced liver damage, oxidative stress, fibrosis, and restored normal activity of MMP-9 and MMP-2.	Curcumin	25-33	matrix metallopeptidase 9	Rattus norvegicus	116-121
32673649-11	2020	Besides, curcumin restored NF-kappaB, IL-1, IL-10, TGF-beta, CTGF, Col-I, MMP-13, and Smad7 protein levels.	Curcumin	9-17	transforming growth factor alpha	Rattus norvegicus	51-59
32673649-11	2020	Besides, curcumin restored NF-kappaB, IL-1, IL-10, TGF-beta, CTGF, Col-I, MMP-13, and Smad7 protein levels.	Curcumin	9-17	matrix metallopeptidase 13	Rattus norvegicus	74-80
28429187-9	2017	Moreover, curcumin increased the hepatic glycogen content by inhibiting glycogen synthase kinase (GSK)-3beta and prevented gluconeogenesis by inhibiting phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase).	Curcumin	10-18	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	222-228
29147611-0	2017	Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice.	Curcumin	62-70	erb-b2 receptor tyrosine kinase 2	Mus musculus	79-87
33176649-0	2020	Curcumin Prevents Neuroinflammation by Inducing Microglia to Transform into the M2-phenotype via CaMKKbeta-dependent Activation of the AMP-Activated Protein Kinase Signal Pathway.	Curcumin	0-8	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	97-106
33176649-4	2020	OBJECTIVE: This study aimed to investigate whether curcumin changed microglia to an anti-inflammatory M2-phenotype by activating the AMP-activated protein kinase (AMPK) signaling pathway.	Curcumin	51-59	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	163-167
29147611-3	2017	In this study, we evaluated the in vitro and in vivo anti-cancer effect of curcumin (CUR) against Her2/neu overexpressing breast cancer cells (TUBO) in the presence or in the absence of the autophagy inhibitor chloroquine (CQ).	Curcumin	75-83	erb-b2 receptor tyrosine kinase 2	Mus musculus	98-106
33176649-10	2020	RESULTS: Curcumin enhanced AMPK activation in BV2 microglial cells in the presence and absence of LPS.	Curcumin	9-17	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	27-31
33176649-12	2020	The effects of curcumin were inhibited by an AMPK inhibitor or AMPK knockdown.	Curcumin	15-23	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	45-49
28187447-6	2017	When the acetylation of H3K9 in the Egr-1 binding site was significantly reduced by the histone acetyltransferase (HAT) inhibitor curcumin, binding of Egr-1 to GDNF promoter II, RNA POL II recruitment, and GDNF mRNA expression were significantly downregulated (P &lt; 0.01).	Curcumin	130-138	early growth response 1	Homo sapiens	36-41
33176649-12	2020	The effects of curcumin were inhibited by an AMPK inhibitor or AMPK knockdown.	Curcumin	15-23	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	63-67
33176649-14	2020	Curcumin can activate AMPK in Hela cells, which do not express LKB1.	Curcumin	0-8	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	22-26
33176649-15	2020	However, both the CaMKKbeta inhibitor and siRNA blocked curcumin activation of AMPK in LPS-stimulated BV2 cells.	Curcumin	56-64	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	18-27
33176649-15	2020	However, both the CaMKKbeta inhibitor and siRNA blocked curcumin activation of AMPK in LPS-stimulated BV2 cells.	Curcumin	56-64	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	79-83
33176649-16	2020	Moreover, the CaMKKbeta inhibitor and siRNA weaken the effect of curcumin suppression on M1 and enhancement of M2 protein and gene expression in LPSstimulated BV2 cells.	Curcumin	65-73	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	14-23
33176649-17	2020	Finally, curcumin enhanced AMPK activation in the brain area where microglia were over-activated upon LPS stimulation in an in vivo neuroinflammation model.	Curcumin	9-17	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	27-31
33176649-19	2020	CONCLUSION: Curcumin enhances microglia M2 polarization via the CaMKKbeta-dependent AMPK signaling pathway.	Curcumin	12-20	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	64-73
33176649-19	2020	CONCLUSION: Curcumin enhances microglia M2 polarization via the CaMKKbeta-dependent AMPK signaling pathway.	Curcumin	12-20	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	84-88
28187447-7	2017	Moreover, curcumin attenuated the effects of Egr-1 overexpression on Egr-1 binding, RNA POL II recruitment, and GDNF transcription (P &lt; 0.01).	Curcumin	10-18	early growth response 1	Homo sapiens	45-50
28187447-7	2017	Moreover, curcumin attenuated the effects of Egr-1 overexpression on Egr-1 binding, RNA POL II recruitment, and GDNF transcription (P &lt; 0.01).	Curcumin	10-18	early growth response 1	Homo sapiens	69-74
28235660-10	2017	Curcumin, another polyphenol, can suppress overexpression of inflammatory mediators via inhibiting the TLR4-MAPK/NF-kappaB pathway.	Curcumin	0-8	toll like receptor 4	Homo sapiens	103-107
31573354-8	2020	Consequently, curcumin based therapy could benefit in patients with TNBC particularly especially in women with a BRCA1 mutation.	Curcumin	14-22	BRCA1 DNA repair associated	Homo sapiens	113-118
31630418-7	2020	After blocking Act1/TRAF6/p38MAPK cascade and interfering AP-1 with Curcumin or c-Jun siRNA, CCL2 expression induced by IL-17 was significantly attenuated at both mRNA and protein levels.	Curcumin	68-76	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-62
31630418-7	2020	After blocking Act1/TRAF6/p38MAPK cascade and interfering AP-1 with Curcumin or c-Jun siRNA, CCL2 expression induced by IL-17 was significantly attenuated at both mRNA and protein levels.	Curcumin	68-76	interleukin 17A	Homo sapiens	120-125
28539160-3	2017	Jab1 stimulated phosphorylation of p53 at T155 was inhibited by curcumin, an inhibitor of COP9 signalosome (CSN)-associated kinases.	Curcumin	64-72	COP9 signalosome subunit 8	Homo sapiens	90-94
32270742-13	2020	Treatment with prednisolone, in combination with theophylline, curcumin or resveratrol increases SIRT1 expression, restores steroid sensitivity, and inhibits pro-inflammatory cytokine production from these cells and may reduce systemic inflammation in COPD.	Curcumin	63-71	sirtuin 1	Homo sapiens	97-102
29201078-0	2017	Anticancer Activity of Curcumin-Loaded PLGA Nanoparticles on PC3 Prostate Cancer Cells.	Curcumin	23-31	chromobox 8	Homo sapiens	61-64
31849448-0	2019	Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury.	Curcumin	37-45	mitogen-activated protein kinase 8	Mus musculus	14-17
31849448-4	2019	Curcumin analog C66, having reported as an inhibitor of c-Jun N-terminal kinase (JNK), exhibits anti-inflammatory property both in vitro and in vivo.	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	56-79
31849448-4	2019	Curcumin analog C66, having reported as an inhibitor of c-Jun N-terminal kinase (JNK), exhibits anti-inflammatory property both in vitro and in vivo.	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	81-84
28705118-0	2017	Curcumin inhibits bladder cancer progression via regulation of beta-catenin expression.	Curcumin	0-8	catenin beta 1	Homo sapiens	63-75
31027431-6	2019	RESULTS: Our study showed that the chrysin-curcumin-loaded nanofibres have anti-inflammatory properties in several stages of the wound-healing process by affecting the IL-6, MMP-2, TIMP-1, TIMP-2 and iNOS gene expression.	Curcumin	43-51	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	181-187
27137748-2	2017	In this study, nanocurcumin combined with 8 mT AC static magnetic field was used to enhance cellular uptake, bioavailability, and ultimate efficiency of curcumin against prostate cancer cell line (PC3), four bacteria strains (two Gram positive: Micrococcus luteus ATCC 9341, Staphylococcus aureus ATCC 29213 and two Gram negative: Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853), mammalian cell line (HEK) and human erythrocytes (RBC).	Curcumin	19-27	chromobox 8	Homo sapiens	197-200
31627991-0	2019	Design, synthesis and biological evaluation of curcumin analogues as novel LSD1 inhibitors.	Curcumin	47-55	lysine demethylase 1A	Homo sapiens	75-79
31627991-4	2019	Utilizing a structure-based drug design strategy, we designed and synthesized a series of curcumin analogues that were shown to be potent LSD1 inhibitors in the enzyme assay.	Curcumin	90-98	lysine demethylase 1A	Homo sapiens	138-142
31627991-8	2019	These findings suggested that compounds WA20 and WB07 are the first curcumin analogue-based LSD1 inhibitors with remarkable A549 suppressive activity, providing a novel scaffold for the development of LSD1 inhibitors.	Curcumin	68-76	lysine demethylase 1A	Homo sapiens	92-96
31627991-8	2019	These findings suggested that compounds WA20 and WB07 are the first curcumin analogue-based LSD1 inhibitors with remarkable A549 suppressive activity, providing a novel scaffold for the development of LSD1 inhibitors.	Curcumin	68-76	lysine demethylase 1A	Homo sapiens	201-205
27137748-3	2017	The efficiency (E%) between IC50 of nanocurcumin combined with magnetic field (NANOCUR-MF) and control against PC3 was 35.93%, which is three times higher compared to curcumin combined with magnetic field (CUR-MF); i.e., 10.77%.	Curcumin	40-48	chromobox 8	Homo sapiens	111-114
31751886-10	2019	Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation.	Curcumin	9-17	interleukin 10	Homo sapiens	155-160
28599484-0	2017	Anticancer effect of curcumin inhibits cell growth through miR-21/PTEN/Akt pathway in breast cancer cell.	Curcumin	21-29	microRNA 21	Homo sapiens	59-65
28599484-0	2017	Anticancer effect of curcumin inhibits cell growth through miR-21/PTEN/Akt pathway in breast cancer cell.	Curcumin	21-29	phosphatase and tensin homolog	Homo sapiens	66-70
28599484-9	2017	miR-21 was transfected into MCF-7 cells and the anticancer effect of curcumin on cell viability and the expression of PTEN and pAkt was analyzed.	Curcumin	69-77	microRNA 21	Homo sapiens	0-6
31571501-1	2019	In this study, novel multifunctional folic acid, biotin, and CD44 receptors targeted and pH-sensitive "nano-actiniaes" were fabricated with icariin (ICA) and curcumin (Cur) as loaded model drugs for breast cancer therapy.	Curcumin	158-166	CD44 molecule (Indian blood group)	Homo sapiens	61-65
31571501-1	2019	In this study, novel multifunctional folic acid, biotin, and CD44 receptors targeted and pH-sensitive "nano-actiniaes" were fabricated with icariin (ICA) and curcumin (Cur) as loaded model drugs for breast cancer therapy.	Curcumin	168-171	CD44 molecule (Indian blood group)	Homo sapiens	61-65
28599484-11	2017	In addition, curcumin downregulated miR-21 expression in MCF-7 cells by upregulating the PTEN/Akt signaling pathway.	Curcumin	13-21	microRNA 21	Homo sapiens	36-42
28599484-11	2017	In addition, curcumin downregulated miR-21 expression in MCF-7 cells by upregulating the PTEN/Akt signaling pathway.	Curcumin	13-21	phosphatase and tensin homolog	Homo sapiens	89-93
28599484-12	2017	The present study has for the first time, to the best of our knowledge, revealed the anticancer effect of curcumin in suppressing breast cancer cell growth, and has elucidated that the miR-21/PTEN/Akt signaling pathway is a key mechanism for the anticancer effects of curcumin.	Curcumin	106-114	microRNA 21	Homo sapiens	185-191
31841214-10	2019	The integrins alpha3, alpha5, and beta1 were involved in curcumin"s regulation of adhesion and migration.	Curcumin	57-65	integrin subunit alpha 3	Homo sapiens	4-39
28599484-12	2017	The present study has for the first time, to the best of our knowledge, revealed the anticancer effect of curcumin in suppressing breast cancer cell growth, and has elucidated that the miR-21/PTEN/Akt signaling pathway is a key mechanism for the anticancer effects of curcumin.	Curcumin	106-114	phosphatase and tensin homolog	Homo sapiens	192-196
28599484-12	2017	The present study has for the first time, to the best of our knowledge, revealed the anticancer effect of curcumin in suppressing breast cancer cell growth, and has elucidated that the miR-21/PTEN/Akt signaling pathway is a key mechanism for the anticancer effects of curcumin.	Curcumin	268-276	microRNA 21	Homo sapiens	185-191
28599484-12	2017	The present study has for the first time, to the best of our knowledge, revealed the anticancer effect of curcumin in suppressing breast cancer cell growth, and has elucidated that the miR-21/PTEN/Akt signaling pathway is a key mechanism for the anticancer effects of curcumin.	Curcumin	268-276	phosphatase and tensin homolog	Homo sapiens	192-196
28618934-7	2017	Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 and ITGA2B), collagen ( COL5A1), and laminin ( LAMA5) were significantly inhibited by curcumin at messenger RNA and protein levels.	Curcumin	191-199	integrin alpha 2b	Mus musculus	109-115
29088758-4	2017	In this report we show that miR-378, a glioblastoma multiforme down regulated miRNA, may enhance the inhibitory effect of curcumin on this cancer growth.	Curcumin	122-130	microRNA 378a	Homo sapiens	28-35
31675556-4	2019	Here, we reveal that curcumin significantly enhanced the growth inhibition of regorafenib in human colorectal cancer HCT 116 cells (KRAS mutant) to a greater extent than in human colorectal cancer HT-29 cells (KRAS wild-type), producing an additive or synergistic effect in HCT 116 cells and causing an antagonistic effect in HT-29 cells.	Curcumin	21-29	KRAS proto-oncogene, GTPase	Homo sapiens	132-136
31675556-7	2019	Our data suggest that curcumin may target one more gene other than mutant KRAS to enhance regorafenib-induced growth inhibition (synthetic lethality) in colorectal cancer HCT 116 cells, indicating a possible role of curcumin in regorafenib-treated KRAS mutant colorectal cancer.	Curcumin	22-30	KRAS proto-oncogene, GTPase	Homo sapiens	248-252
31710976-0	2019	Curcumin inhibits proliferation and soluble collagen synthesis of NIH/3T3 cell line by modulation of miR-29a and via ERK1/2 and beta-catenin pathways.	Curcumin	0-8	catenin (cadherin associated protein), beta 1	Mus musculus	128-140
31741405-8	2019	Furthermore, curcumin upregulated the expression of E-cadherin and LC3 proteins and downregulated the vimentin, TWIST1, p62, p-mTOR, p-Akt and P13K levels in DN rats and MPC5 cells.	Curcumin	13-21	mechanistic target of rapamycin kinase	Rattus norvegicus	127-131
31741405-9	2019	However, fumonisin B1 or 3BDO reversed the effects of curcumin on the expression of these proteins in cells.Discussion and conclusions: The protection against development of DN by curcumin treatment involved changes in inducing autophagy and alleviating podocyte EMT, through the PI3k/Akt/mTOR pathway, providing the scientific basis for further research and clinical applications of curcumin.	Curcumin	54-62	mechanistic target of rapamycin kinase	Rattus norvegicus	289-293
31741405-9	2019	However, fumonisin B1 or 3BDO reversed the effects of curcumin on the expression of these proteins in cells.Discussion and conclusions: The protection against development of DN by curcumin treatment involved changes in inducing autophagy and alleviating podocyte EMT, through the PI3k/Akt/mTOR pathway, providing the scientific basis for further research and clinical applications of curcumin.	Curcumin	180-188	mechanistic target of rapamycin kinase	Rattus norvegicus	289-293
31741405-9	2019	However, fumonisin B1 or 3BDO reversed the effects of curcumin on the expression of these proteins in cells.Discussion and conclusions: The protection against development of DN by curcumin treatment involved changes in inducing autophagy and alleviating podocyte EMT, through the PI3k/Akt/mTOR pathway, providing the scientific basis for further research and clinical applications of curcumin.	Curcumin	180-188	mechanistic target of rapamycin kinase	Rattus norvegicus	289-293
29088758-5	2017	Our results indicated that the inhibitory effect of curcumin was enhanced in miR-378-expressing stable U87 cells in vitro and in vivo, compared to control cells.	Curcumin	52-60	microRNA 378a	Homo sapiens	77-84
29088758-7	2017	Thus, we concluded that miR-378 enhances the response of glioblastoma multiforme to curcumin treatment, by targeting p38.	Curcumin	84-92	microRNA 378a	Homo sapiens	24-31
29926590-14	2017	CONCLUSIONS: Curcumin can promote the recovery of hindlimb motor function after spinal cord injury in rats.The mechanism is through inhibition of NF-K B to prevent inflammation; And inhibition the expression of Bax and Caspase-3, and promotion the expression of Bcl-2 to prevent apoptosis, so as to accelerate the recovery of motor function in the rats after spinal cord injury.	Curcumin	13-21	BCL2 associated X, apoptosis regulator	Rattus norvegicus	211-214
28391351-12	2017	Both miR-143 overexpression and curcumin treatment inhibited PGK1 expression and ectopic expression of PGK1 antagonized curcumin"s antitumor effects.	Curcumin	32-40	phosphoglycerate kinase 1	Homo sapiens	61-65
28391351-12	2017	Both miR-143 overexpression and curcumin treatment inhibited PGK1 expression and ectopic expression of PGK1 antagonized curcumin"s antitumor effects.	Curcumin	32-40	phosphoglycerate kinase 1	Homo sapiens	103-107
31780732-3	2019	We have investigated the stimulating role of curcumin (CURC) on CISP-induced human laryngeal squamous cancer (Hep2) cell death through TRPM2 channel activation, and its protective role against the adverse effects of CISP in normal kidney (MPK) cells.	Curcumin	55-59	transient receptor potential cation channel subfamily M member 2	Homo sapiens	135-140
28391351-12	2017	Both miR-143 overexpression and curcumin treatment inhibited PGK1 expression and ectopic expression of PGK1 antagonized curcumin"s antitumor effects.	Curcumin	120-128	phosphoglycerate kinase 1	Homo sapiens	103-107
31819422-0	2019	Co-Delivery of Prednisolone and Curcumin in Human Serum Albumin Nanoparticles for Effective Treatment of Rheumatoid Arthritis.	Curcumin	32-40	albumin	Rattus norvegicus	50-63
28391351-16	2017	PGK1 is downregulated by miR-143, and FOXD3 upregulation is essential for the antitumor effect of curcumin.	Curcumin	98-106	phosphoglycerate kinase 1	Homo sapiens	0-4
31754130-6	2019	The results showed that curcumin combined with 5 muM DAC may inhibit cancer cell colony formation, migration through EMT (epithelial-mesenchymal transition) process regulation, total DNMT activity, especially in DNMT3a protein expression, and may also regulate tumor suppressor gene SFRP5 expression involved in the Wnt/beta-catenin signaling pathway.	Curcumin	24-32	DNA methyltransferase 1	Homo sapiens	183-187
31788011-11	2019	Curcumin also markedly down-regulated the protein expression of hepatic TLR4 and myeloid differentiation factor 88 (MyD88), inhibited p65 nuclear translocation and DNA binding activity of nuclear factor-kappaB (NF-kappaB) in the liver.	Curcumin	0-8	myeloid differentiation primary response gene 88	Mus musculus	81-114
31788011-11	2019	Curcumin also markedly down-regulated the protein expression of hepatic TLR4 and myeloid differentiation factor 88 (MyD88), inhibited p65 nuclear translocation and DNA binding activity of nuclear factor-kappaB (NF-kappaB) in the liver.	Curcumin	0-8	myeloid differentiation primary response gene 88	Mus musculus	116-121
28188823-4	2017	Our previous researches have shown that the natural product curcumin could promote the senescence of activated HSC.	Curcumin	60-68	fucosyltransferase 1 (H blood group)	Homo sapiens	111-114
31436299-9	2019	The results demonstrated a significant decrease in EMT following exposure to 20 microM curcumin for 72 h. This finding was supported by a decrease in the protein expression levels of N-cadherin, Vimentin and Slug.	Curcumin	87-95	cadherin 2	Homo sapiens	183-193
31436299-9	2019	The results demonstrated a significant decrease in EMT following exposure to 20 microM curcumin for 72 h. This finding was supported by a decrease in the protein expression levels of N-cadherin, Vimentin and Slug.	Curcumin	87-95	snail family transcriptional repressor 2	Homo sapiens	208-212
32083122-0	2019	Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	22-27
32083122-6	2019	For molecular mechanism, curcumin reduced the mRNA expression levels of ERK2 and JUN genes and inhibited the phosphorylation of ERK and c-Jun.	Curcumin	25-33	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-141
32083122-7	2019	This suggests that curcumin inhibits the proliferation of endometrial carcinoma cells by downregulating ERK/c-Jun signaling pathway activity.	Curcumin	19-27	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	108-113
32002054-0	2019	Curcumin"s Effect on COX-2 and IL-10 Serum in Preeclampsia"s Patient Undergo Sectio Caesarea with Spinal Anesthesia.	Curcumin	0-8	interleukin 10	Homo sapiens	31-36
32002054-2	2019	Curcumin affects several biological markers that are thought to play a role in the pathogenesis of preeclampsia such as IL-10 and COX-2, resulting in an improvement in pregnant women with preeclampsia.	Curcumin	0-8	interleukin 10	Homo sapiens	120-125
28188823-6	2017	We found that senescent HSC induced by curcumin are susceptible to NK cells killing, due to the increased expression of NK cell activating ligand major histocompatibility complex class I chain-related genes A (MICA) and UL16-binding proteins 2 (ULBP2), but not Poliovirus Receptor (PVR).	Curcumin	39-47	fucosyltransferase 1 (H blood group)	Homo sapiens	24-27
32002054-3	2019	AIM: To see the effect of perioperative curcumin administration on IL-10 and COX-2 in preeclamptic patients undergoing caesarean section under spinal anaesthesia.	Curcumin	40-48	interleukin 10	Homo sapiens	67-72
28584445-0	2017	A comparative molecular docking study of curcumin and methotrexate to dihydrofolate reductase.	Curcumin	41-49	dihydrofolate reductase	Homo sapiens	70-93
31030375-10	2019	Curcumin or THC complexes in HP-CDs with improved bioavailability also induced anti-oxidant activity (SOD1, CAT1, and HMOX1) in higher levels in the ocular epithelial cells and showed oxidative protection effects in rabbit cornea tissues that will boost up their application in ocular medicine.	Curcumin	0-8	heme oxygenase 1	Oryctolagus cuniculus	118-123
31377611-0	2019	Mitochondrial targeting nano-curcumin for attenuation on PKM2 and FASN.	Curcumin	29-37	fatty acid synthase	Homo sapiens	66-70
31612395-5	2019	Now we showed that curcumin increased LD formation in activated HSCs and stimulated the expression of sterol regulatory element-binding protein and fatty acid synthase, and reduced the expression of adipose triglyceride lipase.	Curcumin	19-27	fatty acid synthase	Homo sapiens	148-167
31696502-17	2019	Flow cytometry results indicated that curcumin-induced remarkable apoptosis in TH1, TH17, and Treg cells.	Curcumin	38-46	negative elongation factor complex member C/D	Homo sapiens	79-82
28584445-1	2017	Interaction of curcumin (CUR) with the enzyme dihydrofolate reductase (DHFR) was studied by molecular docking using AutoDock 4.2 as the docking software application.	Curcumin	15-23	dihydrofolate reductase	Homo sapiens	46-69
28584445-1	2017	Interaction of curcumin (CUR) with the enzyme dihydrofolate reductase (DHFR) was studied by molecular docking using AutoDock 4.2 as the docking software application.	Curcumin	15-23	dihydrofolate reductase	Homo sapiens	71-75
31998463-4	2019	The present study aimed to compare cyclin D1 (CCN D1) gene expression in hepatocellular carcinoma cell line (HUH7) when it is treated with nanomicelle curcumin and sorafenib.	Curcumin	151-159	MIR7-3 host gene	Homo sapiens	109-113
31998463-6	2019	Materials and Methods: The toxic dose (IC50) of nanomicelle curcumin and sorafenib were detected after treatment of HUH7 cell lines with different dose of mentioned agents followed by MTT assay.	Curcumin	60-68	MIR7-3 host gene	Homo sapiens	116-120
28584445-3	2017	Interactions of curcumin with DHFR were compared to those of methotrexate (MTX), a known inhibitor of the enzyme.	Curcumin	16-24	dihydrofolate reductase	Homo sapiens	30-34
31998463-10	2019	The finding of this study revealed that, in comparison to sorafenib alone, the treatment of HUH7 with a nanomicelle curcumin IC50 dose, in combination with sorafenib, might down-regulate CCN D1 gene expression.	Curcumin	116-124	MIR7-3 host gene	Homo sapiens	92-96
28584445-8	2017	Thus, curcumin can be considered as a good lead compound in the development of new inhibitors of DHFR, which is a potential target of anti-cancer drugs.	Curcumin	6-14	dihydrofolate reductase	Homo sapiens	97-101
28377722-11	2017	Our results reveal that curcumin-activated autophagy could maintain proteostasis in ER leading to attenuation of ER stress and subsequent inhibition of JNK/IRS-1 pathway and improvement of insulin resistance.	Curcumin	24-32	insulin receptor substrate 1	Homo sapiens	156-161
28199187-5	2017	The PCa cell lines DU145 and PC3 were treated with curcumin and docetaxel alone or in combination.	Curcumin	51-59	chromobox 8	Homo sapiens	29-32
31089060-0	2019	miR-15b-5p targeting amyloid precursor protein is involved in the anti-amyloid eflect of curcumin in swAPP695-HEK293 cells.	Curcumin	89-97	microRNA 15b	Homo sapiens	0-7
27996348-7	2017	Moreover, compared with the control, FZD exposure activated the protein and mRNA expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1), which were further activated by curcumin treatment.	Curcumin	214-222	heme oxygenase 1	Homo sapiens	157-173
31089060-10	2019	Curcumin suppressed the expression of amyloid precursor protein and amyloid-beta and up-regulated the expression of miR-15b-5p in swAPP695-HEK293 cells.	Curcumin	0-8	microRNA 15b	Homo sapiens	116-123
31089060-11	2019	In addition, we found a negative association of miR-15b-5p expression with amyloid precursor protein and amyloid-beta levels in the curcumin-treated cells.	Curcumin	132-140	microRNA 15b	Homo sapiens	48-55
30869142-8	2019	In addition, dietary curcumin increased gene expression of GST, MRP6, and ABCB1 in jejunal mucosa.	Curcumin	21-29	ATP-dependent translocase ABCB1	Anas platyrhynchos	74-79
27996348-7	2017	Moreover, compared with the control, FZD exposure activated the protein and mRNA expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1), which were further activated by curcumin treatment.	Curcumin	214-222	heme oxygenase 1	Homo sapiens	175-179
31330227-6	2019	Moreover, curcumin pretreatment increased Nrf2 nuclear translocation and downstream enzyme expression, heme oxygenase-1 (HO-1) and NADPH quinone reductase-1 (NQO1).	Curcumin	10-18	heme oxygenase 1	Rattus norvegicus	103-119
27996348-8	2017	These results reveal that curcumin could prevent FZD induced cytotoxicity and S phase arrest, which may involve the activation of Nrf2/HO-1 pathway and the inhibition of p38 MAPK pathway and ER stress.	Curcumin	26-34	heme oxygenase 1	Homo sapiens	135-139
31472681-12	2019	Curcumin (20 muM) significantly suppressed PA- or TG-induced decrease in cell viability, caspase 3 activity, and the expression levels of BAX, CHOP, and GRP78.	Curcumin	0-8	BCL2-associated X protein	Mus musculus	138-141
28261097-0	2017	Curcumin Alleviates oxLDL Induced MMP-9 and EMMPRIN Expression through the Inhibition of NF-kappaB and MAPK Pathways in Macrophages.	Curcumin	0-8	basigin (Ok blood group)	Homo sapiens	44-51
31754658-6	2019	Moreover, the levels of phosphorylated tau at Ser396 (PHF13), Ser202/Thr205 (AT8), and Abeta40/42 (MOAB2) were decreased significantly in AD rats treated with curcumin.	Curcumin	159-167	PHD finger protein 13	Rattus norvegicus	54-59
31754658-8	2019	Furthermore, Cdk5 and its activators p35 and p25 were significantly decreased in curcumin-treated AD rats.	Curcumin	81-89	cyclin-dependent kinase 5 regulatory subunit 1	Rattus norvegicus	37-40
28261097-4	2017	Here we evaluated the impact of curcumin on the expression of MMP-9 and EMMPRIN in macrophages.	Curcumin	32-40	basigin (Ok blood group)	Homo sapiens	72-79
28261097-8	2017	Here we showed that curcumin attenuated the MMP-9 and EMMPRIN expression in oxLDL stimulated macrophages.	Curcumin	20-28	basigin (Ok blood group)	Homo sapiens	54-61
31754658-9	2019	The reduced levels of Cdk5, p35, p25, and GSK3beta in curcumin-treated AD rats may result decreased Abeta aggregation and tau hyperphosphorylation, thus ameliorating AD.	Curcumin	54-62	cyclin-dependent kinase 5 regulatory subunit 1	Rattus norvegicus	28-31
28261097-10	2017	These findings illustrated that curcumin can inhibit the expression of EMMPRIN and MMP-9 in oxLDL stimulated macrophages through down regulation of NF-kappaB and p38 MAPK signaling pathways, which might be the molecular mechanism for the anti-atherosclerotic effect of curcumin.	Curcumin	32-40	basigin (Ok blood group)	Homo sapiens	71-78
28261097-10	2017	These findings illustrated that curcumin can inhibit the expression of EMMPRIN and MMP-9 in oxLDL stimulated macrophages through down regulation of NF-kappaB and p38 MAPK signaling pathways, which might be the molecular mechanism for the anti-atherosclerotic effect of curcumin.	Curcumin	269-277	basigin (Ok blood group)	Homo sapiens	71-78
28120490-6	2017	Curcumin inhibited the survival and proliferation of PC3 and DU145 cells in a dose- and time-dependent manner and inhibited DU145 migration.	Curcumin	0-8	proprotein convertase subtilisin/kexin type 1	Homo sapiens	53-56
28272691-14	2017	In curcumin-treated rats, the expression of Bcl-2 and Survivin were significantly decreased while Bax protein expression was significantly elevated (p &lt; 0.05).	Curcumin	3-11	BCL2 associated X, apoptosis regulator	Rattus norvegicus	98-101
31399137-6	2019	IL-2 (+ 192%), IL-13 (+ 87%), IL-17A (+ 81%) and fractalkine (+ 121%) were higher while RANTES was lower (- 22%) with curcumin supplementation in the treatment arm (p < 0.05 for all).	Curcumin	118-126	C-C motif chemokine ligand 5	Rattus norvegicus	88-94
31399137-9	2019	Moreover, curcumin"s effect(s) on RANTES and its association with liver disease pathogenesis and progression may warrant further investigation.	Curcumin	10-18	C-C motif chemokine ligand 5	Rattus norvegicus	34-40
31392057-0	2019	A combined treatment of curcumin, piperine, and taurine alters the circulating levels of IL-10 and miR-21 in hepatocellular carcinoma patients: a pilot study.	Curcumin	24-32	interleukin 10	Homo sapiens	89-94
31392057-3	2019	Thus, this study was designed to assess the effect of a combined treatment consisted of curcumin, piperine, and taurine on circulating levels of interleukin-10 (IL-10), and microRNAs miR-141 and miR-21.	Curcumin	88-96	interleukin 10	Homo sapiens	145-159
27817102-10	2017	Of note, the expression of p-Akt increased by curcumin was accompanied by the decreased chemokines MCP-1 and MIP-1 levels and fewer CD68-positive macrophages in the placenta.	Curcumin	46-54	transportin 1	Mus musculus	109-114
31392057-3	2019	Thus, this study was designed to assess the effect of a combined treatment consisted of curcumin, piperine, and taurine on circulating levels of interleukin-10 (IL-10), and microRNAs miR-141 and miR-21.	Curcumin	88-96	interleukin 10	Homo sapiens	161-166
28146408-0	2017	The Antimalarial Effect of Curcumin Is Mediated by the Inhibition of Glycogen Synthase Kinase-3beta.	Curcumin	27-35	glycogen synthase kinase 3 beta	Mus musculus	69-99
31097226-5	2019	The transcription levels of cyp302a1 and cyp306a1 were significantly decreased in BmN cells after treatment with the double stranded RNA of BmCncC (dsBmCncC), whereas their transcription levels were significantly increased (2.15- and 1.31-fold, respectively) after treatment with the CncC agonist Curcumin.	Curcumin	297-305	cytochrome P450 302A1	Bombyx mori	28-36
31097226-5	2019	The transcription levels of cyp302a1 and cyp306a1 were significantly decreased in BmN cells after treatment with the double stranded RNA of BmCncC (dsBmCncC), whereas their transcription levels were significantly increased (2.15- and 1.31-fold, respectively) after treatment with the CncC agonist Curcumin.	Curcumin	297-305	cytochrome P450 monooxygenase	Bombyx mori	41-49
28146408-2	2017	In silico docking simulation studies suggest that curcumin possesses glycogen synthase kinase-3beta (GSK3beta)-inhibitory properties.	Curcumin	50-58	glycogen synthase kinase 3 beta	Mus musculus	69-99
30421467-17	2019	CXCL1 and TNF-alpha both represent potential biomarkers for the future study of curcumin chemoprevention.	Curcumin	80-88	C-X-C motif chemokine ligand 1	Homo sapiens	0-5
28146408-2	2017	In silico docking simulation studies suggest that curcumin possesses glycogen synthase kinase-3beta (GSK3beta)-inhibitory properties.	Curcumin	50-58	glycogen synthase kinase 3 beta	Mus musculus	101-109
30951849-9	2019	Like curcumin, anti-Abeta antibody (also reported to engage the Syk pathway, increase CD68, and decrease amyloid burden in human and mouse brain) increased TREM2 in APPsw mice and decreased amyloid in human AD sections ex vivo.	Curcumin	5-13	spleen associated tyrosine kinase	Homo sapiens	64-67
34055082-6	2021	Furthermore, curcumin pretreatment before stroke was shown to downregulate the phosphorylation of NF-kappaB and MMP-9, which are central mediators of inflammation.	Curcumin	13-21	matrix metallopeptidase 9	Rattus norvegicus	112-117
30951849-9	2019	Like curcumin, anti-Abeta antibody (also reported to engage the Syk pathway, increase CD68, and decrease amyloid burden in human and mouse brain) increased TREM2 in APPsw mice and decreased amyloid in human AD sections ex vivo.	Curcumin	5-13	CD68 molecule	Homo sapiens	86-90
28146408-4	2017	In this study, we aimed to evaluate whether the antimalarial effects of curcumin involve phosphorylation of host GSK3beta.	Curcumin	72-80	glycogen synthase kinase 3 beta	Mus musculus	113-121
30951849-9	2019	Like curcumin, anti-Abeta antibody (also reported to engage the Syk pathway, increase CD68, and decrease amyloid burden in human and mouse brain) increased TREM2 in APPsw mice and decreased amyloid in human AD sections ex vivo.	Curcumin	5-13	triggering receptor expressed on myeloid cells 2	Mus musculus	156-161
31252572-6	2019	Consistent with these data, curcumin stimulation upregulates the expression of Suppressors of cytokine signaling (SOCS)-1, whereas phosphorylation of the JAK2 and STAT3 was reduced.	Curcumin	28-36	suppressor of cytokine signaling 1	Mus musculus	79-121
31275848-9	2019	Curcumin treatment of B-Pre-ALL cell lines induced a dephosphorylation of the constitutive phosphorylated AKT/PKB and a down-regulation of the expression of cIAP1, and XIAP.	Curcumin	0-8	X-linked inhibitor of apoptosis	Homo sapiens	168-172
28146408-10	2017	Findings from the present study demonstrate for the first time that the antimalarial action of curcumin involved inhibition of GSK3beta.	Curcumin	95-103	glycogen synthase kinase 3 beta	Mus musculus	127-135
31196210-12	2019	Curcumin can be used as a sensitizer to enhance the efficacy of EGFR-TKIs and overcome the EGFR-TKI resistance in NSCLC patients with wild-type EGFR and/or KRAS mutation.	Curcumin	0-8	KRAS proto-oncogene, GTPase	Homo sapiens	156-160
27491636-0	2017	Curcumin improves episodic memory in cadmium induced memory impairment through inhibition of acetylcholinesterase and adenosine deaminase activities in a rat model.	Curcumin	0-8	acetylcholinesterase	Rattus norvegicus	93-113
30918132-0	2019	Curcumin Ameliorates Chronic Renal Failure in 5/6 Nephrectomized Rats by Regulation of the mTOR/HIF-1alpha/VEGF Signaling Pathway.	Curcumin	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	91-95
30918132-0	2019	Curcumin Ameliorates Chronic Renal Failure in 5/6 Nephrectomized Rats by Regulation of the mTOR/HIF-1alpha/VEGF Signaling Pathway.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	96-106
30918132-2	2019	Therefore, the aim of the present study was to investigate the therapeutic effects of curcumin against chronic renal failure (CRF) in a rat model induced by 5/6 nephrectomy through inhibition of mTOR/HIF-1alpha/VEGF signaling.	Curcumin	86-94	mechanistic target of rapamycin kinase	Rattus norvegicus	195-199
28145533-0	2017	Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells.	Curcumin	26-34	transformation related protein 53, pseudogene	Mus musculus	82-85
30918132-2	2019	Therefore, the aim of the present study was to investigate the therapeutic effects of curcumin against chronic renal failure (CRF) in a rat model induced by 5/6 nephrectomy through inhibition of mTOR/HIF-1alpha/VEGF signaling.	Curcumin	86-94	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	200-210
33631181-0	2021	Curcumin promotes venous thrombi resolve process in a mouse deep venous thrombosis model via regulating miR-499.	Curcumin	0-8	microRNA 499	Mus musculus	104-111
33631181-5	2021	Microarray analysis and RT-PCR were performed to examine the expression level of miR-499 in thrombosis after curcumin administration.	Curcumin	109-117	microRNA 499	Mus musculus	81-88
33631181-9	2021	The expression of miR-499 exhibited notably downregulated after curcumin administration.	Curcumin	64-72	microRNA 499	Mus musculus	18-25
33631181-10	2021	The proangiogenic effect of curcumin in HUVECs could be blocked by miR-499 overexpression.	Curcumin	28-36	microRNA 499	Mus musculus	67-74
33631181-13	2021	Mechanically, curcumin promotes therapeutic angiogenesis by regulating miR-499 mediated PTEN/VEGF/Ang-1 signaling pathway.	Curcumin	14-22	microRNA 499	Mus musculus	71-78
33631181-13	2021	Mechanically, curcumin promotes therapeutic angiogenesis by regulating miR-499 mediated PTEN/VEGF/Ang-1 signaling pathway.	Curcumin	14-22	vascular endothelial growth factor A	Mus musculus	93-97
28145533-6	2017	Wortmannin (PI-3Kinases inhibitor), SP600125 (JNK inhibitor) and pifithrin-alpha (p53 inhibitor) abrogated curcumin-mediated induction of Bex genes.	Curcumin	107-115	transformation related protein 53, pseudogene	Mus musculus	82-85
33684690-0	2021	Curcumin suppresses the malignancy of non-small cell lung cancer by modulating the circ-PRKCA/miR-384/ITGB1 pathway.	Curcumin	0-8	integrin subunit beta 1	Homo sapiens	102-107
30928100-0	2019	The effects of curcumin, mangiferin, resveratrol and other natural plant products on aminopeptidase B activity.	Curcumin	15-23	arginyl aminopeptidase	Homo sapiens	85-101
28145533-7	2017	Inhibition of curcumin-mediated induction of Bex genes by pifithrin-alpha also inhibited N2a cells apoptosis suggesting, a direct role of Bex genes in N2a cells apoptosis and involvement of p53 in Bex genes induction.	Curcumin	14-22	transformation related protein 53, pseudogene	Mus musculus	190-193
33684690-10	2021	After curcumin treatment, the expression tendency of circ-PRKCA, miR-384, and ITGB1 in NSCLC cells was overturned.	Curcumin	6-14	integrin subunit beta 1	Homo sapiens	78-83
33684690-11	2021	Furthermore, curcumin impeded viability, colony formation, migration, invasion, and accelerated apoptosis of NSCLC cells, but these impacts were partially reversed by circ-PRKCA elevation, miR-384 downregulation, or ITGB1 overexpression.	Curcumin	13-21	integrin subunit beta 1	Homo sapiens	216-221
28145533-8	2017	Curcumin treatment activated p53 through hyperphosphorylation at serine 15 before Bex genes induction indicating Bex genes are novel downstream targets of p53.	Curcumin	0-8	transformation related protein 53, pseudogene	Mus musculus	29-32
33684690-13	2021	Notably, circ-PRKCA regulated ITGB1 expression through sponging miR-384 in curcumin-treated NSCLC cells.	Curcumin	75-83	integrin subunit beta 1	Homo sapiens	30-35
28145533-8	2017	Curcumin treatment activated p53 through hyperphosphorylation at serine 15 before Bex genes induction indicating Bex genes are novel downstream targets of p53.	Curcumin	0-8	transformation related protein 53, pseudogene	Mus musculus	155-158
33684690-14	2021	CONCLUSIONS: Curcumin inhibited NSCLC growth through downregulating circ-PRKCA, which regulated ITGB1 expression by adsorbing miR-384.	Curcumin	13-21	integrin subunit beta 1	Homo sapiens	96-101
27355903-2	2017	In Ldlr-/- mice fed a high-fat diet (HFD), curcumin reduces plasma lipid levels, therefore contributing to a lower accumulation of lipids and to reduced expression of fatty acid transport proteins (CD36/FAT, FABP4/aP2) in peritoneal macrophages.	Curcumin	43-51	CD36 molecule	Mus musculus	27-30
33713277-0	2021	Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway.	Curcumin	0-8	transcription factor AP-2 alpha	Homo sapiens	98-104
33713277-9	2021	In addition, we also found that curcumin inhibited the extracellular matrix (ECM)-receptor interaction pathway via the downregulation of the following genes: GP1BB, COL9A3, COMP, AGRN, ITGB4, LAMA5, COL2A1, ITGB6, ITGA1, and TNC.	Curcumin	32-40	glycoprotein Ib platelet subunit beta	Homo sapiens	158-163
33713277-9	2021	In addition, we also found that curcumin inhibited the extracellular matrix (ECM)-receptor interaction pathway via the downregulation of the following genes: GP1BB, COL9A3, COMP, AGRN, ITGB4, LAMA5, COL2A1, ITGB6, ITGA1, and TNC.	Curcumin	32-40	collagen type IX alpha 3 chain	Homo sapiens	165-171
33713277-9	2021	In addition, we also found that curcumin inhibited the extracellular matrix (ECM)-receptor interaction pathway via the downregulation of the following genes: GP1BB, COL9A3, COMP, AGRN, ITGB4, LAMA5, COL2A1, ITGB6, ITGA1, and TNC.	Curcumin	32-40	agrin	Homo sapiens	179-183
33713277-9	2021	In addition, we also found that curcumin inhibited the extracellular matrix (ECM)-receptor interaction pathway via the downregulation of the following genes: GP1BB, COL9A3, COMP, AGRN, ITGB4, LAMA5, COL2A1, ITGB6, ITGA1, and TNC.	Curcumin	32-40	tenascin C	Homo sapiens	225-228
33713277-11	2021	In conclusion, curcumin suppressed LGR5(+) colorectal CSCs, potentially by inducing autophagy and repressing the oncogenic TFAP2A-mediated ECM pathway.	Curcumin	15-23	transcription factor AP-2 alpha	Homo sapiens	123-129
33211286-0	2021	Curcumin Attenuates Hypoxia-Induced Oxidative Neurotoxicity, Apoptosis, Calcium, and Zinc Ion Influxes in a Neuronal Cell Line: Involvement of TRPM2 Channel.	Curcumin	0-8	transient receptor potential cation channel subfamily M member 2	Homo sapiens	143-148
30679022-0	2019	Rutin and curcumin reduce inflammation, triglyceride levels and ADA activity in serum and immune cells in a model of hyperlipidemia.	Curcumin	10-18	adenosine deaminase	Rattus norvegicus	64-67
30988793-8	2019	The results revealed that curcumin-supplemented culture medium increased hLMP-3 osteogenic potency compared with that of MEFs cultured in the non-supplemented medium.	Curcumin	26-34	PDZ and LIM domain 7	Homo sapiens	73-79
30988793-9	2019	The present results demonstrate that enrichment of the osteogenic culture medium with curcumin, a natural osteogenic inducer, increased the osteogenic differentiation capacity of BMSCs as well as that of MEFs reprogrammed with hLMP-3.	Curcumin	86-94	PDZ and LIM domain 7	Homo sapiens	227-233
31005718-13	2019	Western blot analysis demonstrated that curcumin decreased the protein expression of stem cell genes including Oct4, Nanog and Sox2.	Curcumin	40-48	Nanog homeobox	Homo sapiens	117-122
31005718-13	2019	Western blot analysis demonstrated that curcumin decreased the protein expression of stem cell genes including Oct4, Nanog and Sox2.	Curcumin	40-48	SRY-box transcription factor 2	Homo sapiens	127-131
31061679-7	2019	Results: Treatment of diabetic rats with curcumin or metformin alone decreased the plasma levels of glucose, triacylglycerol, cholesterol, TBARS, and fluorescent AGEs, as well as increased the activity of PON 1.	Curcumin	41-49	paraoxonase 1	Rattus norvegicus	205-210
31061679-8	2019	The combination of metformin with curcumin further decreased dyslipidemia and TBARS levels in diabetic rats, indicating synergy, and maintained the high levels of PON 1.	Curcumin	34-42	paraoxonase 1	Rattus norvegicus	163-168
31061679-9	2019	Conclusion: These findings indicated that curcumin combined with metformin may act synergistically on dyslipidemia and oxidative stress, as well as increased PON 1 levels.	Curcumin	42-50	paraoxonase 1	Rattus norvegicus	158-163
31086728-0	2019	A combination of curcumin, vorinostat and silibinin reverses Abeta-induced nerve cell toxicity via activation of AKT-MDM2-p53 pathway.	Curcumin	17-25	MDM2 proto-oncogene	Rattus norvegicus	117-121
27355903-2	2017	In Ldlr-/- mice fed a high-fat diet (HFD), curcumin reduces plasma lipid levels, therefore contributing to a lower accumulation of lipids and to reduced expression of fatty acid transport proteins (CD36/FAT, FABP4/aP2) in peritoneal macrophages.	Curcumin	43-51	CD36 molecule	Mus musculus	203-206
30747999-7	2019	The percentage of recorded CA1 neurons displaying SLEs was lower in curcumin-treated slice cultures compared to vehicle-treated slices (25.8% vs 72.5%), whereas rapamycin did not reduce SLE occurrence significantly (52%).	Curcumin	68-76	carbonic anhydrase 1	Homo sapiens	27-30
28585209-3	2017	Interestingly, , food preservatives like sodium sulfite and sodium benzoate and also natural colorant and spice compounds such as curcumin were found to decrease the release of leptin in murine 3T3-L1 adipocytes, after co-incubation with LPS, which was added to mimic the pro-inflammatory status in obesity.	Curcumin	130-138	leptin	Mus musculus	177-183
33955148-5	2021	We found that GLUT1 was highly expressed and negatively associated with autophagy-related proteins in LC and that curcumin suppressed radiation-mediated GLUT1 overexpression in Tu212 cells.	Curcumin	114-122	solute carrier family 2 member 1	Homo sapiens	14-19
33955148-5	2021	We found that GLUT1 was highly expressed and negatively associated with autophagy-related proteins in LC and that curcumin suppressed radiation-mediated GLUT1 overexpression in Tu212 cells.	Curcumin	114-122	solute carrier family 2 member 1	Homo sapiens	153-158
33955148-10	2021	We also found that autophagy induction after curcumin or GLUT1 siRNA treatment implicated in the AMP-activated protein kinase-mTOR-serine/threonine-protein kinase-Beclin1 signalling pathway.	Curcumin	45-53	beclin 1	Homo sapiens	163-170
29132216-0	2017	Curcumin Decreases Hyperphosphorylation of Tau by Down-Regulating Caveolin-1/GSK-3beta in N2a/APP695swe Cells and APP/PS1 Double Transgenic Alzheimer"s Disease Mice.	Curcumin	0-8	caveolin 1, caveolae protein	Mus musculus	66-76
33662896-4	2021	Furthermore, among the series, L5, L12, L9, L10, L8 and L11 were identified as more potent inhibitors of alpha-Glu enzyme than curcumin and the compounds of L12, L4, L9, L5, L10, L8, L13, and L11 were the stronger inhibitors of the alpha-Amy enzyme in vitro.	Curcumin	127-135	immunoglobulin kappa variable 1-6	Homo sapiens	56-59
33791015-5	2021	Curcumin treatment resulted in a reduction of breast cancer cell proliferation and induction of apoptosis, an effect that may be mediated by manipulating Trx system components, mainly Trx expression, and to a lesser extent TrxR1 expression and concentration.	Curcumin	0-8	thioredoxin reductase 1	Homo sapiens	223-228
30934593-0	2019	Protective Effects of CISD2 and Influence of Curcumin on CISD2 Expression in Aged Animals and Inflammatory Cell Model.	Curcumin	45-53	CDGSH iron sulfur domain 2	Mus musculus	57-62
30934593-3	2019	We previously reported that curcumin attenuates the downregulation of CISD2 in animal models of spinal cord injury and lipopolysaccharide (LPS)-treated neuronal cells.	Curcumin	28-36	CDGSH iron sulfur domain 2	Mus musculus	70-75
30934593-4	2019	In this study, we investigate (1) the role of CISD2 and (2) how curcumin regulates CISD2 in the aging process.	Curcumin	64-72	CDGSH iron sulfur domain 2	Mus musculus	83-88
30934593-8	2019	Curcumin treatment in vivo and in vitro was shown to upregulate CISD2 expression; attenuate inflammatory response in neural cells.	Curcumin	0-8	CDGSH iron sulfur domain 2	Mus musculus	64-69
33791015-6	2021	Furthermore, curcumin increased the sensitivity of breast cancer cells to chemotherapy and radiotherapy by reducing Trx and TrxR1 expression levels.	Curcumin	13-21	thioredoxin reductase 1	Homo sapiens	124-129
30934593-9	2019	Moreover, curcumin treatment elevated CISD2 expression levels and prevented mitochondrial dysfunction in LPS-challenged neural cells.	Curcumin	10-18	CDGSH iron sulfur domain 2	Mus musculus	38-43
29132216-0	2017	Curcumin Decreases Hyperphosphorylation of Tau by Down-Regulating Caveolin-1/GSK-3beta in N2a/APP695swe Cells and APP/PS1 Double Transgenic Alzheimer"s Disease Mice.	Curcumin	0-8	presenilin 1	Mus musculus	118-121
30934593-11	2019	CONCLUSIONS: We hypothesize that the protective effects of curcumin treatment in reducing cellular inflammation associated trauma, degenerative, and aging processes can be partially attributed to elevated CISD2 expression.	Curcumin	59-67	CDGSH iron sulfur domain 2	Mus musculus	205-210
30934593-12	2019	We observed a reduction in the protective effects of curcumin against injury-induced inflammation and mitochondrial dysfunction in cells where CISD2 expression was reduced by siCISD2.	Curcumin	53-61	CDGSH iron sulfur domain 2	Mus musculus	143-148
33450459-15	2021	In a mouse-derived intestinal epithelial 3D organoid culture stimulated with IL-1beta, BLG-CUR and crosslinked BCEP nanoparticles reduced the production of inflammatory cytokines and chemokines such as Tnfalpha and Cxcl10 more than curcumin solution or suspension while these nanoparticles were non-toxic to organoids.	Curcumin	232-240	beta-lactoglobulin	Bos taurus	87-90
29132216-3	2017	In our previous studies, curcumin has been confirmed to play a neuroprotective role in Alzheimer"s disease (AD), but its effects on Caveolin-1, Tau and their correlation, and the mechanism is still unknown.	Curcumin	25-33	caveolin 1, caveolae protein	Mus musculus	132-142
33922657-3	2021	In this study, we demonstrated that curcumin, a plant polyphenol, sensitizes BRCA2-deficient cells to CPT-11 by impairing RAD52 recombinase in MCF7 cells.	Curcumin	36-44	BRCA2 DNA repair associated	Homo sapiens	77-82
33922657-6	2021	In vivo, xenograft model studies showed that curcumin combined with CPT-11 reduced the growth of BRCA2-knockout MCF7 tumors but not MCF7 tumors.	Curcumin	45-53	BRCA2 DNA repair associated	Homo sapiens	97-102
33922657-7	2021	In conclusion, our data indicate that curcumin, which has RAD52 inhibitor activity, is a promising candidate for sensitizing BRCA2-deficient cells to DNA damage-based cancer therapies.	Curcumin	38-46	BRCA2 DNA repair associated	Homo sapiens	125-130
33864298-8	2021	For the first time, the current study reveals that curcumin restores TGF-beta1 induced peroxisomes like PEX-13, PEX-14, PEX-19, and ACOX1.	Curcumin	51-59	acyl-CoA oxidase 1	Homo sapiens	132-137
33935747-0	2021	Curcumin Derivative Cur20 Attenuated Cerebral Ischemic Injury by Antioxidant Effect and HIF-1alpha/VEGF/TFEB-Activated Angiogenesis.	Curcumin	0-8	vascular endothelial growth factor A	Mus musculus	99-103
33411217-8	2021	Conversely, various doses of curcumin attenuated DCAA-induced oxidative stress, inflammation response and impaired synaptic plasticity, while elevating cAMP, PKA, p-CREB, BDNF, PSD-95, SYP levels.	Curcumin	29-37	brain-derived neurotrophic factor	Rattus norvegicus	171-175
33411217-8	2021	Conversely, various doses of curcumin attenuated DCAA-induced oxidative stress, inflammation response and impaired synaptic plasticity, while elevating cAMP, PKA, p-CREB, BDNF, PSD-95, SYP levels.	Curcumin	29-37	synaptophysin	Rattus norvegicus	185-188
33174301-7	2021	RESULTS: The results revealed a significant effect of curcumin supplementation on reducing creatine kinase (CK) (weighted mean difference [WMD] = -48.54 IU.L-1 ; 95% CI: -80.667, -16.420; p = .003) and muscle soreness index decrease (WMD = -0.476; 95% CI: -0.750, -0.202; p = .001).	Curcumin	54-62	cytidine/uridine monophosphate kinase 1	Homo sapiens	91-106
33174301-7	2021	RESULTS: The results revealed a significant effect of curcumin supplementation on reducing creatine kinase (CK) (weighted mean difference [WMD] = -48.54 IU.L-1 ; 95% CI: -80.667, -16.420; p = .003) and muscle soreness index decrease (WMD = -0.476; 95% CI: -0.750, -0.202; p = .001).	Curcumin	54-62	cytidine/uridine monophosphate kinase 1	Homo sapiens	108-110
33174301-8	2021	Moreover, a subgroup analysis resulted in a significant decrease in CK concentrations and muscle soreness index, according to follow-ups after exercise, dose of curcumin, duration of studies, exercise type, train status and study design.	Curcumin	161-169	cytidine/uridine monophosphate kinase 1	Homo sapiens	68-70
33174301-9	2021	CONCLUSIONS: The current evidence revealed a efficacy of curcumin in reducing CK serum levels and muscle soreness index among adults.	Curcumin	57-65	cytidine/uridine monophosphate kinase 1	Homo sapiens	78-80
33787509-0	2021	Correction for: Curcumin suppresses osteogenesis by inducing miR-126a-3p and subsequently suppressing the WNT/LRP6 pathway.	Curcumin	16-24	LDL receptor related protein 6	Homo sapiens	110-114
33730297-0	2021	Curcumin protects against inflammation and lung injury in rats with acute pulmonary embolism with the involvement of microRNA-21/PTEN/NF-kappaB axis.	Curcumin	0-8	microRNA 21	Rattus norvegicus	117-128
33730297-0	2021	Curcumin protects against inflammation and lung injury in rats with acute pulmonary embolism with the involvement of microRNA-21/PTEN/NF-kappaB axis.	Curcumin	0-8	phosphatase and tensin homolog	Rattus norvegicus	129-133
33730297-1	2021	This study was intended to investigate the effect of Curcumin on acute pulmonary embolism (APE) via microRNA-21 (miR-21)/PTEN/NF-kappaB axis.	Curcumin	53-61	microRNA 21	Rattus norvegicus	100-111
33730297-1	2021	This study was intended to investigate the effect of Curcumin on acute pulmonary embolism (APE) via microRNA-21 (miR-21)/PTEN/NF-kappaB axis.	Curcumin	53-61	microRNA 21	Rattus norvegicus	113-119
33730297-1	2021	This study was intended to investigate the effect of Curcumin on acute pulmonary embolism (APE) via microRNA-21 (miR-21)/PTEN/NF-kappaB axis.	Curcumin	53-61	phosphatase and tensin homolog	Rattus norvegicus	121-125
33730297-3	2021	Western blot analysis and RT-qPCR manifested the downregulation of Sp1, miR-21 and NF-kappaB, but the upregulation of PTEN in Curcumin-treated APE rats.	Curcumin	126-134	phosphatase and tensin homolog	Rattus norvegicus	118-122
33730297-8	2021	In summary, Curcumin decreased miR-21 expression by downregulating Sp1 to upregulate PTEN and to impair the NF-kappaB signaling pathway, thus suppressing lung injury and inflammation in APE rats.	Curcumin	12-20	microRNA 21	Rattus norvegicus	31-37
33730297-8	2021	In summary, Curcumin decreased miR-21 expression by downregulating Sp1 to upregulate PTEN and to impair the NF-kappaB signaling pathway, thus suppressing lung injury and inflammation in APE rats.	Curcumin	12-20	phosphatase and tensin homolog	Rattus norvegicus	85-89
33959308-11	2021	Moreover, curcumin markedly increased the mRNA and protein expressions of mitochondrial uncoupling protein 1 (UCP1), PPARgamma, peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) and PR domain protein 16 (PRDM16) in vivo and in vitro.	Curcumin	10-18	PR domain containing 16	Mus musculus	213-233
33959308-11	2021	Moreover, curcumin markedly increased the mRNA and protein expressions of mitochondrial uncoupling protein 1 (UCP1), PPARgamma, peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) and PR domain protein 16 (PRDM16) in vivo and in vitro.	Curcumin	10-18	PR domain containing 16	Mus musculus	235-241
33959308-12	2021	Collectively, the results demonstrate that curcumin promotes the adipogenic differentiation of preadipocytes and mitochondrial oxygen consumption in 3T3-L1 mature adipocytes by regulating UCP1, PRDM16, PPARgamma and PGC-1alpha expression.	Curcumin	43-51	PR domain containing 16	Mus musculus	194-200
32694760-0	2021	Oral administration of curcumin ameliorates pulmonary fibrosis in mice through 15d-PGJ2-mediated induction of hepatocyte growth factor in the colon.	Curcumin	23-31	hepatocyte growth factor	Mus musculus	110-134
32694760-5	2021	We showed that oral administration of curcumin indeed significantly increased the expression of gut-derived hepatocyte growth factor (HGF) in colon tissues.	Curcumin	38-46	hepatocyte growth factor	Mus musculus	108-132
32694760-5	2021	We showed that oral administration of curcumin indeed significantly increased the expression of gut-derived hepatocyte growth factor (HGF) in colon tissues.	Curcumin	38-46	hepatocyte growth factor	Mus musculus	134-137
32694760-6	2021	Furthermore, in bleomycin-treated mice, the upregulated protein level of HGF in lungs by oral curcumin was highly correlated with its anti-PF effect, which was further confirmed by coadministration of c-Met inhibitor SU11274.	Curcumin	94-102	hepatocyte growth factor	Mus musculus	73-76
32694760-7	2021	Curcumin (5-40 muM) dose-dependently increased HGF expression in primary mouse fibroblasts, macrophages, CCD-18Co cells (fibroblast cell line), and RAW264.7 cells (monocyte-macrophage cell line), but not in primary colonic epithelial cells.	Curcumin	0-8	hepatocyte growth factor	Mus musculus	47-50
33574907-0	2021	HSP60 participates in the anti-glioma effects of curcumin.	Curcumin	49-57	heat shock protein family D (Hsp60) member 1	Homo sapiens	0-5
33574907-4	2021	The present study assessed whether CCM exerted its anti-neuroglioma effects on U87 cells via inhibition of HSP60/TLR-4 signaling, similar to that in microglia.	Curcumin	35-38	heat shock protein family D (Hsp60) member 1	Homo sapiens	107-112
33574907-9	2021	Based on the results of the present study, CCM may exert its anti-tumor effects in U87 cells by inhibiting the HSP60/TLR-4/MYD88/NF-kappaB pathway and inducing tumor cell apoptosis.	Curcumin	43-46	heat shock protein family D (Hsp60) member 1	Homo sapiens	111-116
32648259-1	2021	The current work examined the outcome of curcumin (20 mg/kg body weight/day) administration on arginase and adenosine deaminase (ADA) activities and other kidney markers, as well as markers of oxidative stress, in Wistar rats exposed to sodium nitrite (NaNO2 ) (60 mg/kg of body weight, single dose) for 28 days.	Curcumin	41-49	adenosine deaminase	Rattus norvegicus	108-127
32648259-1	2021	The current work examined the outcome of curcumin (20 mg/kg body weight/day) administration on arginase and adenosine deaminase (ADA) activities and other kidney markers, as well as markers of oxidative stress, in Wistar rats exposed to sodium nitrite (NaNO2 ) (60 mg/kg of body weight, single dose) for 28 days.	Curcumin	41-49	adenosine deaminase	Rattus norvegicus	129-132
32648259-3	2021	However, pretreatment with curcumin significantly mitigated the altered activities ADA and arginase as well as other parameters.	Curcumin	27-35	adenosine deaminase	Rattus norvegicus	83-86
32648259-5	2021	Our findings suggest that the alteration in the activities of ADA and arginase could be involved in the mechanism of action employed by NaNO2 and curcumin in the respective induction and prevention of nephrotoxicity.	Curcumin	146-154	adenosine deaminase	Rattus norvegicus	62-65
32648259-6	2021	PRACTICAL APPLICATIONS: These results suggest that moderate exposure to the acceptable daily dose of curcumin can improve food-related kidney damage through regulations of ADA and arginase activities, enhancement in the antioxidant system, and suppression of lipid peroxidation.	Curcumin	101-109	adenosine deaminase	Rattus norvegicus	172-175
32985484-4	2021	Our results revealed that solid lipid nanoparticle loading with curcumin and dexanabinol increased the mRNA and protein expression levels of the mature neuronal markers neuronal nuclei, mitogen-activated protein 2, and neuron-specific beta-tubulin III, promoted the release of dopamine and norepinephrine, and increased the mRNA expression of CBR1 and the downstream genes Rasgef1c and Egr1, and simultaneously improved rat locomotor function.	Curcumin	64-72	RasGEF domain family, member 1C	Rattus norvegicus	373-381
33597887-5	2020	After 7 days of continuous curcumin (100 mg/kg/day) administration, the DSS-induced experimental colitis was effectively relieved, with significant decreases in the ratio of day weight to initial body weight, colonic weight, pathological injury score, levels of proinflammatory cytokines IL-7, IL-15, and IL-21, colonic mucosal ulceration, and amount of inflammatory infiltrate.	Curcumin	27-35	interleukin 15	Homo sapiens	294-299
33597887-5	2020	After 7 days of continuous curcumin (100 mg/kg/day) administration, the DSS-induced experimental colitis was effectively relieved, with significant decreases in the ratio of day weight to initial body weight, colonic weight, pathological injury score, levels of proinflammatory cytokines IL-7, IL-15, and IL-21, colonic mucosal ulceration, and amount of inflammatory infiltrate.	Curcumin	27-35	interleukin 21	Homo sapiens	305-310
33597887-6	2020	Importantly, curcumin significantly restored the percentages of naive, TCM, and TEM cells and their CD4+ and CD8+ subpopulations.	Curcumin	13-21	CD4 antigen	Mus musculus	100-103
33572685-4	2021	Curcumin was explored with potent antiherpetic actions against herpes simplex virus type 1 and type 2, human cytomegalovirus, Kaposi"s sarcoma-associated herpesvirus, Epstein-Barr virus, bovine herpesvirus 1, and pseudorabies virus.	Curcumin	0-8	type 1 and type 2	None	84-101
33160958-0	2021	Curcumin promotes neurogenesis of hippocampal dentate gyrus via Wnt/beta-catenin signal pathway following cerebral ischemia in mice.	Curcumin	0-8	catenin (cadherin associated protein), beta 1	Mus musculus	68-80
33160958-1	2021	OBJECTIVES: To investigate whether curcumin promotes hippocampal neurogenesis in the cerebral ischemia (CI) mice via Wnt/beta-catenin signaling pathway.	Curcumin	35-43	catenin (cadherin associated protein), beta 1	Mus musculus	121-133
33160958-10	2021	Curcumin also increased the expression of proteins involved in neurogenesis (including Ngn2, Pax6 and NeuroD 1) and the Wnt/beta-catenin signaling pathway.	Curcumin	0-8	catenin (cadherin associated protein), beta 1	Mus musculus	124-136
33160958-12	2021	CONCLUSION: Curcumin promotes hippocampal neurogenesis by activating Wnt/beta-catenin signaling pathway to ameliorate cognitive deficits after acute CI.	Curcumin	12-20	catenin (cadherin associated protein), beta 1	Mus musculus	73-85
32360175-12	2021	However, curcumin (20 muM) and SB203580 (20 muM) only down-regulated the stimulatory effects of GroEL on IL-6.	Curcumin	9-17	heat shock protein family D (Hsp60) member 1	Homo sapiens	96-101
33952798-0	2021	Curcumin promotes cholesterol efflux by regulating ABCA1 expression through miR-125a-5p/SIRT6 axis in THP-1 macrophage to prevent atherosclerosis.	Curcumin	0-8	ATP binding cassette subfamily A member 1	Homo sapiens	51-56
33179078-9	2021	IL-10 level in the colon was significantly increased, while inflammatory cytokines IL-6, IL-17 and IL-23 were significantly reduced following curcumin treatment.	Curcumin	142-150	interleukin 17A	Mus musculus	89-94
33368058-9	2020	Two molecules, curcumin and catechin, bind directly to the receptor-binding domain of the S-protein and the angiotensin-converting enzyme 2 receptor of the host cell, by which these molecules inhibit the entry of viruses in the host cell.	Curcumin	15-23	vitronectin	Homo sapiens	90-99
33350580-9	2020	In conclusion, oral administration of curcumin shows hepatoprotective effects against APAP-overdose induced hepatic damage in normal and gamma-irradiated rats through prospective regulation of the therapeutic targets CYP2E1, Nrf2, and NF-kappaB, via organizing the miR-122 and miR-802 gene expression.	Curcumin	38-46	microRNA 802	Rattus norvegicus	277-284
33058920-6	2020	Molecular docking and other studies confirmed that curcumin could bind to and upregulate the expression of TET2 and TET3 with hydrogen bonds and arene-H bonds, suggesting that demethylation of RB1 was attributed to reactivation of the demethylation enzymes TET2 and TET3 after curcumin treatment.	Curcumin	51-59	RB transcriptional corepressor 1	Mus musculus	193-196
33058920-6	2020	Molecular docking and other studies confirmed that curcumin could bind to and upregulate the expression of TET2 and TET3 with hydrogen bonds and arene-H bonds, suggesting that demethylation of RB1 was attributed to reactivation of the demethylation enzymes TET2 and TET3 after curcumin treatment.	Curcumin	277-285	RB transcriptional corepressor 1	Mus musculus	193-196
33308125-10	2021	A comet assay revealed that CCl4 challenge resulted in significant DNA damage as documented by a 70% increase in nuclear DNA tail-length; treatment with AgNPs-curcumin inhibited the CCL4-mediated increase in nuclear DNA tail-length by 34%.	Curcumin	159-167	chemokine (C-C motif) ligand 4	Mus musculus	28-32
33308125-10	2021	A comet assay revealed that CCl4 challenge resulted in significant DNA damage as documented by a 70% increase in nuclear DNA tail-length; treatment with AgNPs-curcumin inhibited the CCL4-mediated increase in nuclear DNA tail-length by 34%.	Curcumin	159-167	chemokine (C-C motif) ligand 4	Mus musculus	182-186
32893845-0	2020	Reduced Caudal Type Homeobox 2 (CDX2) Promoter Methylation Is Associated with Curcumin"s Suppressive Effects on Epithelial-Mesenchymal Transition in Colorectal Cancer Cells.	Curcumin	78-86	caudal type homeobox 2	Homo sapiens	8-30
32893845-0	2020	Reduced Caudal Type Homeobox 2 (CDX2) Promoter Methylation Is Associated with Curcumin"s Suppressive Effects on Epithelial-Mesenchymal Transition in Colorectal Cancer Cells.	Curcumin	78-86	caudal type homeobox 2	Homo sapiens	32-36
32893845-10	2020	Curcumin incubation significantly downregulated expression levels of DNA methyltransferase1 (DNMT1), DNMT3a, and the methylation levels of the cdx2 promoter in a concentration-dependent manner.	Curcumin	0-8	DNA methyltransferase 1	Homo sapiens	69-91
32893845-10	2020	Curcumin incubation significantly downregulated expression levels of DNA methyltransferase1 (DNMT1), DNMT3a, and the methylation levels of the cdx2 promoter in a concentration-dependent manner.	Curcumin	0-8	DNA methyltransferase 1	Homo sapiens	93-98
32893845-10	2020	Curcumin incubation significantly downregulated expression levels of DNA methyltransferase1 (DNMT1), DNMT3a, and the methylation levels of the cdx2 promoter in a concentration-dependent manner.	Curcumin	0-8	caudal type homeobox 2	Homo sapiens	143-147
32893845-11	2020	The expression levels of N-cadherin, Vimentin, Wnt3a, Snail1, and Twist, as well as the nuclear translocation levels of ss-catenin, were reduced in a curcumin concentration-dependent manner.	Curcumin	150-158	cadherin 2	Homo sapiens	25-35
32893845-13	2020	CONCLUSIONS Curcumin negatively regulated transcription factors promoting EMT in CRC cells by decreasing cdx2 promoter DNA methylation and consequently suppressing the CDX2/Wnt3a/ss-catenin signaling pathway.	Curcumin	12-20	caudal type homeobox 2	Homo sapiens	105-109
32893845-13	2020	CONCLUSIONS Curcumin negatively regulated transcription factors promoting EMT in CRC cells by decreasing cdx2 promoter DNA methylation and consequently suppressing the CDX2/Wnt3a/ss-catenin signaling pathway.	Curcumin	12-20	caudal type homeobox 2	Homo sapiens	168-172
32464442-9	2020	Furthermore, pretreatment of curcumin with arsenic expressively alleviated arsenic-induced toxicity and cell death by reversing the expressions of proteins; mTOR, Akt, Nrf2, ERK1, Bcl-x, Xiap, ULK, LC3, p53, Bax, cytochrome c, caspase 9 and cleaved caspase 3.	Curcumin	29-37	mechanistic target of rapamycin kinase	Rattus norvegicus	157-161
32765696-2	2020	The aim of the current study was to investigate the association between the anti-osteoporotic effect of curcumin (Cur) and the transforming growth factor (TGF)beta/Smads signaling pathway.	Curcumin	104-112	transforming growth factor alpha	Rattus norvegicus	127-163
32765696-2	2020	The aim of the current study was to investigate the association between the anti-osteoporotic effect of curcumin (Cur) and the transforming growth factor (TGF)beta/Smads signaling pathway.	Curcumin	114-117	transforming growth factor alpha	Rattus norvegicus	127-163
32782494-9	2020	However, pretreatment with curcumin increased the expression of ABCA1 and cholesterol efflux and suppressed secretion of TNF-alpha, MCP-1 and Il-6.	Curcumin	27-35	ATP binding cassette subfamily A member 1	Homo sapiens	64-69
32811563-12	2020	Curcumin administration especially at the dose of 100 mg/kg upregulated the TERT mRNA expression and enhanced the number of TERT-positive cells in ACR-intoxicated cortex tissues.	Curcumin	0-8	telomerase reverse transcriptase	Rattus norvegicus	76-80
32811563-12	2020	Curcumin administration especially at the dose of 100 mg/kg upregulated the TERT mRNA expression and enhanced the number of TERT-positive cells in ACR-intoxicated cortex tissues.	Curcumin	0-8	telomerase reverse transcriptase	Rattus norvegicus	124-128
32811563-15	2020	Maintaining TERT-related anti-apoptotic function might be one mechanism underlying the protective effect of curcumin on ACR-intoxicated brains.	Curcumin	108-116	telomerase reverse transcriptase	Rattus norvegicus	12-16
32770697-0	2020	Curcumin and Baicalin ameliorate ethanol-induced liver oxidative damage via the Nrf2/HO-1 pathway.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	85-89
32770697-8	2020	Combination treatment of Curcumin and Baicalin significantly reversed the ethanol-induced liver oxidative damage and further activate the Nrf2/HO-1 pathway, which was more effective than each drug alone.	Curcumin	25-33	heme oxygenase 1	Rattus norvegicus	143-147
32626932-10	2020	In addition, curcumin increased the expression levels of the voltage-gated potassium channels Kv2.1 and Kv3.2.	Curcumin	13-21	potassium voltage-gated channel subfamily B member 1	Homo sapiens	94-99
32141025-6	2020	RESULTS: Curcumin augments TRAIL-apoptotic signaling in leukemic cells by upregulating the expression of DR4 and DR5 along with suppression of cFLIP and anti-apoptotic proteins Mcl-1, Bcl-xl, and XIAP.	Curcumin	9-17	X-linked inhibitor of apoptosis	Homo sapiens	196-200
32703287-4	2020	METHODS: In this study, we investigated the role of curcumin in regulating the production of several chemokines (CCL2, CCL3 and CX3CL1) and the migration of OCPs by ELISA, Western blotting and Transwell assays.	Curcumin	52-60	chemokine (C-C motif) ligand 2	Mus musculus	113-117
32707771-0	2020	Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults.	Curcumin	45-53	brain derived neurotrophic factor	Homo sapiens	81-85
30875761-0	2019	Uncovering the Neuroprotective Mechanisms of Curcumin on Transthyretin Amyloidosis.	Curcumin	45-53	transthyretin	Homo sapiens	57-70
30875761-6	2019	The effects of curcumin on ATTR amyloidosis will be reviewed and discussed in the current work in order to contribute to knowledge of the molecular mechanisms involved in TTR amyloidosis and propose more efficient drugs for therapy.	Curcumin	15-23	transthyretin	Homo sapiens	28-31
30844765-6	2019	Mechanistically, Curcumin reduced CXCR4 expression in PGCs in vitro and in vivo, and thus likely inhibited metastasis of PGC through suppression of stromal cell -derived factor-1/CXCR4 signaling.	Curcumin	17-25	C-X-C motif chemokine receptor 4	Homo sapiens	34-39
30844765-6	2019	Mechanistically, Curcumin reduced CXCR4 expression in PGCs in vitro and in vivo, and thus likely inhibited metastasis of PGC through suppression of stromal cell -derived factor-1/CXCR4 signaling.	Curcumin	17-25	C-X-C motif chemokine receptor 4	Homo sapiens	179-184
30626802-8	2019	Finally, curcumin-dependent SP1 reduction was diminished by anti-oxidant N-acetylcystein (NAC) and proteasomal inhibitor MG-132, suggesting the crucial roles of oxidative and proteasomal degradation pathways.	Curcumin	9-17	X-linked Kx blood group	Homo sapiens	73-94
30881359-9	2019	Moreover, pharmacological inhibition of AMPK was found to reverse the observed reduction of DC maturation by carnosol and curcumin.	Curcumin	122-130	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	40-44
30881359-10	2019	This study therefore describes a novel relationship between metabolic signaling via AMPK and HO-1 induction by carnosol and curcumin in human DC, and characterizes the effects of these polyphenols on DC immunometabolism for the first time.	Curcumin	124-132	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	84-88
30860465-0	2019	One novel curcumin derivative ZYX01 induces autophagy of human non-small lung cancer cells A549 through AMPK/ULK1/Beclin-1 signaling pathway.	Curcumin	10-18	beclin 1	Homo sapiens	114-122
30467667-4	2019	This study aimed to investigate the role of NF-kappaB signaling and miR-182-96-183 cluster expression profile on autocrine GH-mediated curcumin resistance, which was prevented by time-dependent curcumin treatment in T47D breast cancer cells.	Curcumin	135-143	microRNA 182	Homo sapiens	68-75
30467667-4	2019	This study aimed to investigate the role of NF-kappaB signaling and miR-182-96-183 cluster expression profile on autocrine GH-mediated curcumin resistance, which was prevented by time-dependent curcumin treatment in T47D breast cancer cells.	Curcumin	194-202	microRNA 182	Homo sapiens	68-75
30679571-0	2019	Curcumin inhibits the TGF-beta1-dependent differentiation of lung fibroblasts via PPARgamma-driven upregulation of cathepsins B and L.	Curcumin	0-8	cathepsin B	Homo sapiens	115-133
30679571-4	2019	Curcumin induced a compelling upregulation of CatB and CatL.	Curcumin	0-8	cathepsin B	Homo sapiens	46-50
28799796-5	2019	Curcumin is a natural anti-inflammatory compound able to induce the expression and production of IL-10 and enhancing its action on a large number of tissues.	Curcumin	0-8	interleukin 10	Homo sapiens	97-102
28799796-6	2019	In vitro and in pre-clinical models curcumin is able to modulate the disease pathophysiology of conditions such as pain and neurodegenerative diseases, bowel inflammation, and allergy, but also of infections and cancer through its effect on IL-10 secretion.	Curcumin	36-44	interleukin 10	Homo sapiens	241-246
28799796-7	2019	In humans, at least one part of the positive effects of curcumin on health could be related to its ability to enhance IL-10 -mediated effects.	Curcumin	56-64	interleukin 10	Homo sapiens	118-123
30616418-1	2019	BACKGROUND: Curcumin, a natural herb that can be isolated from turmeric has been known for its therapeutic potential, including its chemopreventive potential, while heme oxygenase-1 (HO-1) is an antioxidant enzyme that can act as the biomarker for the progression of oral squamous cell carcinoma (OSCC).	Curcumin	12-20	heme oxygenase 1	Rattus norvegicus	183-187
30616418-2	2019	The current study investigated the efficacy of curcumin as a chemopreventive agent for OSCC by evaluating the immunoexpression of HO-1 at epithelial dysplasia stage.	Curcumin	47-55	heme oxygenase 1	Rattus norvegicus	130-134
31679307-8	2019	Curcumin efficiently inhibited HCC cell proliferation by blocking the Wnt/beta-catenin pathway and inhabited migration and invasion by blocking the TGF-p/EMT signal pathway.	Curcumin	0-8	catenin (cadherin associated protein), beta 1	Mus musculus	74-86
30501600-2	2019	Numerous derivatives of curcumin were synthesized, evaluated for their anti-oxidant and free-radical scavenging, SAR, ADME properties and tested in anticancer applications.	Curcumin	24-32	sarcosine dehydrogenase	Homo sapiens	113-116
30599909-7	2019	RESULTS: Our results showed that Curcumin markedly reduced the mRNA expression and secretion of IL-1beta, IL-6, TNFalpha and MCP-1 in LPS stimulated RAW264.7 cell and the supernatant.	Curcumin	33-41	chemokine (C-C motif) ligand 2	Mus musculus	125-130
30599909-9	2019	The data also demonstrated that Curcumin remarkably down-regulated mRNA expression and protein level of Mincle in cis-AKI kidney and also reduced expression of iNOS (M1 macrophage marker) as well as inhibited the activation of Syk and NF-kB.	Curcumin	32-40	spleen tyrosine kinase	Mus musculus	227-230
30599909-11	2019	Furthermore, flow cytometry results showed that Curcumin significantly decreased the iNOS positive macrophages and increased the CD206 (M2 macrophage marker) positive macrophages in vivo and in vitro.	Curcumin	48-56	mannose receptor, C type 1	Mus musculus	129-134
30526546-10	2018	The anti-tumor activities of curcumin on Rb cells appeared to be via up-regulation of miR-99a, and thereby inhibition of JAK/STAT pathway.	Curcumin	29-37	microRNA 99a	Homo sapiens	86-93
30584274-0	2018	Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats.	Curcumin	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	100-104
30584274-8	2018	Curcumin inhibited the CIA-induced mTOR pathway and the RA-induced infiltration of inflammatory cells into the synovium.	Curcumin	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	35-39
30584274-9	2018	Curcumin and rapamycin treatment inhibited the increased levels of proinflammatory cytokines including IL-1beta, TNF-alpha, MMP-1, and MMP-3 in CIA rats.	Curcumin	0-8	matrix metallopeptidase 3	Rattus norvegicus	135-140
30584274-10	2018	Conclusion: Our findings show that curcumin alleviates CIA-induced inflammation, synovial hyperplasia, and the other main features involved in the pathogenesis of CIA via the mTOR pathway.	Curcumin	35-43	mechanistic target of rapamycin kinase	Rattus norvegicus	175-179
29183161-0	2018	Macrophage repolarization using CD44-targeting hyaluronic acid-polylactide nanoparticles containing curcumin.	Curcumin	100-108	CD44 molecule (Indian blood group)	Homo sapiens	32-36
29183161-1	2018	The aim of this study was to evaluate the efficiency of using a natural substance, curcumin, encapsulated in CD44-targeting hyaluronate-polylactide (HA-PLA) nanoparticles (NPs) for the modulation of macrophage polarity from the pro-inflammatory M1 to anti-inflammatory M2 phenotype.	Curcumin	83-91	CD44 molecule (Indian blood group)	Homo sapiens	109-113
29183161-9	2018	Conclusively, the results suggested that the curcumin formulation with CD44-targeting HA-PLA NPs might be a promising platform for the treatment of inflammatory diseases.	Curcumin	45-53	CD44 molecule (Indian blood group)	Homo sapiens	71-75
30272283-6	2018	In addition, cell cycle progression was analyzed by propidium iodide (PI) staining and flow cytometry, and curcumin-induced apoptosis was measured by Annexin V/PI double staining.	Curcumin	107-115	annexin A5	Mus musculus	150-159
30143976-7	2018	Intriguingly, dietary curcumin supplementation modulated autophagy through the activation of beclin-1, ATG5, Dynein, LC3a, LC3b-I/II and downregulation of p53 &amp; mTOR expression level.	Curcumin	22-30	beclin 1	Homo sapiens	93-101
30143976-7	2018	Intriguingly, dietary curcumin supplementation modulated autophagy through the activation of beclin-1, ATG5, Dynein, LC3a, LC3b-I/II and downregulation of p53 &amp; mTOR expression level.	Curcumin	22-30	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	117-121
30466625-5	2018	Curcumin treatment had significantly decreased the phosphorylation of JNK, ERK1/2, and p38 and COX-2 expression thereby nuclear factor kappaB (NF-kappaB) activation and expression in lung tissues.	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	70-73
30546830-1	2018	Synthetic monocarbonyl analogs of curcumin (MACs) are cytotoxic against several cancers including head and neck cancer, pancreatic cancer, colon cancer, and breast cancer.	Curcumin	34-42	myristoylated alanine rich protein kinase C substrate	Mus musculus	44-48
29499209-0	2018	Curcumin restrains hepatic glucose production by blocking cAMP/PKA signaling and reducing acetyl CoA accumulation in high-fat diet (HFD)-fed mice.	Curcumin	0-8	cathelicidin antimicrobial peptide	Mus musculus	58-62
29529355-0	2018	Low-dose curcumin stimulates proliferation of rat embryonic neural stem cells through glucocorticoid receptor and STAT3.	Curcumin	9-17	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	86-109
29529355-6	2018	CONCLUSION: This study shows that low-dose curcumin stimulates the proliferation of NSCs, which is probably by inhibiting the mRNA and protein expressions of GR and directly or indirectly regulating the STAT3 via the synergistic effect of GR and STAT3 pathways and its related signal pathways.	Curcumin	43-51	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	158-160
29529355-6	2018	CONCLUSION: This study shows that low-dose curcumin stimulates the proliferation of NSCs, which is probably by inhibiting the mRNA and protein expressions of GR and directly or indirectly regulating the STAT3 via the synergistic effect of GR and STAT3 pathways and its related signal pathways.	Curcumin	43-51	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	239-241
30056019-6	2018	The cytotoxic and apoptotic effects of curcumin were assessed by sulforhodamine B (SRB) colorimetric assay, flow cytometric cell cycle analysis, and annexin V/propidium iodide (PI) double-labeling assays.	Curcumin	39-47	chaperonin containing TCP1 subunit 4	Homo sapiens	65-81
30056019-6	2018	The cytotoxic and apoptotic effects of curcumin were assessed by sulforhodamine B (SRB) colorimetric assay, flow cytometric cell cycle analysis, and annexin V/propidium iodide (PI) double-labeling assays.	Curcumin	39-47	chaperonin containing TCP1 subunit 4	Homo sapiens	83-86
30218018-6	2018	We validated genes belonging to these pathways, such as HSPA5, SEC61B, G6PD, HMOX1 and PDE3B to be cooperatively modulated by the OPCs-curcumin combination.	Curcumin	135-143	glucose-6-phosphate dehydrogenase	Homo sapiens	71-75
30218018-6	2018	We validated genes belonging to these pathways, such as HSPA5, SEC61B, G6PD, HMOX1 and PDE3B to be cooperatively modulated by the OPCs-curcumin combination.	Curcumin	135-143	phosphodiesterase 3B	Homo sapiens	87-92
29860219-4	2018	Curcumin effectively reversed the expression of CYP3A and CYP7A in fatty liver status to restore metabolism capability.	Curcumin	0-8	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	48-53
29860219-7	2018	In addition, LXRalpha antagonist GGPP pretreatment weakened the curcumin effects on CYP3A, CYP7A and SREBP-1c.	Curcumin	64-72	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	84-89
30150430-7	2018	RESULTS: Both FLJ and curcumin significantly reduced the proliferation and invasion of HSC-3 and SCC-25 cells.	Curcumin	22-30	DnaJ heat shock protein family (Hsp40) member B7	Homo sapiens	87-92
29751146-9	2018	Moreover, the anti-tumor immune response was remarkably improved after curcumin treatment through increasing CD8 positive T cells and decreasing Tregs and MDSCs.	Curcumin	71-79	CD8a molecule	Homo sapiens	109-112
29773381-0	2018	CD44-targeted hyaluronic acid-curcumin prodrug protects renal tubular epithelial cell survival from oxidative stress damage.	Curcumin	30-38	CD44 molecule (Indian blood group)	Homo sapiens	0-4
29901071-9	2018	Curcumin decreased the expression of Trop2 and its downstream target cyclin E1, and increased the level of p27.	Curcumin	0-8	cyclin E1	Homo sapiens	69-78
29901164-0	2018	Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling.	Curcumin	0-8	heat shock protein family A (Hsp70) member 4	Homo sapiens	59-64
29901164-1	2018	Curcumin has been revealed to inhibit liver cancer, however, no studies have reported that the mechanism of curcumin"s action on liver cancer is related to damage-associated molecular pattern (DAMP) molecules heat shock protein 70 (HSP70) and the toll-like receptor 4 (TLR4) signaling.	Curcumin	108-116	heat shock protein family A (Hsp70) member 4	Homo sapiens	209-230
29901164-1	2018	Curcumin has been revealed to inhibit liver cancer, however, no studies have reported that the mechanism of curcumin"s action on liver cancer is related to damage-associated molecular pattern (DAMP) molecules heat shock protein 70 (HSP70) and the toll-like receptor 4 (TLR4) signaling.	Curcumin	108-116	heat shock protein family A (Hsp70) member 4	Homo sapiens	232-237
29901164-2	2018	This study aimed to investigate whether the activation of TLR4 signaling by HSP70 could be inhibited by curcumin, thus investigating the possible mechanism of curcumin in the inhibition of liver cancer.	Curcumin	104-112	heat shock protein family A (Hsp70) member 4	Homo sapiens	76-81
29901164-2	2018	This study aimed to investigate whether the activation of TLR4 signaling by HSP70 could be inhibited by curcumin, thus investigating the possible mechanism of curcumin in the inhibition of liver cancer.	Curcumin	159-167	heat shock protein family A (Hsp70) member 4	Homo sapiens	76-81
29901164-5	2018	A certain concentration of curcumin was co-cultured with HepG2 and HepG2TT cells to observe the changes of HSP70 and TLR4.	Curcumin	27-35	heat shock protein family A (Hsp70) member 4	Homo sapiens	107-112
29901164-7	2018	Curcumin inhibited proliferation, invasion, and metastasis of HepG2 cells, caused cells to remain in the DNA S phase, promoted apoptosis, and significantly reduced intracellular HSP70, eHSP70 and TLR4 levels of HepG2TT cells.	Curcumin	0-8	heat shock protein family A (Hsp70) member 4	Homo sapiens	178-183
29901164-9	2018	In summary, our results demonstrated that the antitumor effect of curcumin was related to the inhibition HSP70-TLR4 signaling.	Curcumin	66-74	heat shock protein family A (Hsp70) member 4	Homo sapiens	105-110
30004453-2	2018	In the present study, we also confirmed by LC3 immunofluorescence and immunoblotting analyses that curcumin triggers autophagy in the human lung adenocarcinoma A549 cell line.	Curcumin	99-107	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	43-46
30004453-5	2018	Deletion analysis demonstrated that the -1146 to -646 region, which includes the putative c-Ets-1, CREB, AP-1, and NF-kappaB binding sites, functions as the curcumin-responsive promoter of hST8Sia I in A549 cells.	Curcumin	157-165	cAMP responsive element binding protein 1	Homo sapiens	99-103
29715758-10	2018	RESULTS: Curcumin significantly reduced the number of apoptotic cells induced by H2O2 and this effect was associated with upregulation of TrkA, Akt and downregulation of p17.	Curcumin	9-17	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	138-142
29715758-15	2018	CONCLUSION: Our findings revealed that curcumin exerts its protective effect against injured neurons through stimulating NGF release which further activates TrkA and PI3K/Akt cell survival signaling.	Curcumin	39-47	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	157-161
30009570-7	2018	Curcumin treatment (12WD vs. 12WD+C) reduced (P &lt; 0.05) hepatocellular inflammation, steatosis, NAFLD Activity Scores, and serum markers of liver injury (AST, ALP).	Curcumin	0-8	PDZ and LIM domain 3	Rattus norvegicus	162-165
29751106-8	2018	In the MCF-7/CLC co-culture, curcumin significantly down-regulated RC3H1, a repressor of inflammatory signaling.	Curcumin	29-37	Charcot-Leyden crystal galectin	Homo sapiens	13-16
29751106-9	2018	In the ZR-75-1/CLC co-culture, curcumin significantly down-regulated PEG10, an anti-apoptotic protein, and induced RRAGA, a pro-apoptotic protein involved in TNF-alpha signaling.	Curcumin	31-39	Charcot-Leyden crystal galectin	Homo sapiens	15-18
31032585-12	2018	Curcumin can up-regulate expression of Nrf2 and HO-1, effectively alleviates oxidative stress induced by overtraining, thereby increasing Bcl-2 expression, decreasing Bax expression, inhibiting renal apoptosis and protecting renal tissue structure and function properly.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	48-52
29604245-7	2018	In SNP-treated chondrocytes, curcumin downregulated the expression of Bax and cleaved caspase-3 but upregulated the expression of Bcl-2, as shown by western blot.	Curcumin	29-37	BCL-2	Oryctolagus cuniculus	130-135
28681665-7	2018	Furthermore, observed increase in the number of apoptotic cells by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), assay and increased activities of caspase 3 and 9 confirmed the induction of apoptosis by curcumin and quercetin.	Curcumin	227-235	caspase 3	Mus musculus	171-186
29693159-0	2018	Effect of curcumin on the cell surface markers CD44 and CD24 in breast cancer.	Curcumin	10-18	CD44 molecule (Indian blood group)	Homo sapiens	47-51
29693159-4	2018	The aim of the present study was to investigate the effects of curcumin on the surface expression of CD44 and CD24 in breast epithelial cell lines.	Curcumin	63-71	CD44 molecule (Indian blood group)	Homo sapiens	101-105
29693159-6	2018	The results revealed that curcumin decreased CD44 and CD24 gene and protein expression levels in MCF-10F (normal), Alpha5 (premalignant) and Tumor2 (malignant) cell lines compared with the levels in their counterpart control cells.	Curcumin	26-34	CD44 molecule (Indian blood group)	Homo sapiens	45-49
29693159-8	2018	Curcumin increased CD44+/CD24+ to a greater extent and decreased CD44+/CD24- subpopulations in the normal MCF-10F and the pre-tumorigenic Alpha5 cells, but had no significant effect on Tumor2 cells compared with the corresponding control cells.	Curcumin	0-8	CD44 molecule (Indian blood group)	Homo sapiens	19-23
29693159-8	2018	Curcumin increased CD44+/CD24+ to a greater extent and decreased CD44+/CD24- subpopulations in the normal MCF-10F and the pre-tumorigenic Alpha5 cells, but had no significant effect on Tumor2 cells compared with the corresponding control cells.	Curcumin	0-8	CD44 molecule (Indian blood group)	Homo sapiens	65-69
29693159-9	2018	Conversely, curcumin increased CD44 and decreased CD24 gene expression in MCF-7 breast cancer cells, and decreased CD44 gene expression in MDA-MB-231 cell line, while CD24 was not present in these cells.	Curcumin	12-20	CD44 molecule (Indian blood group)	Homo sapiens	31-35
29693159-9	2018	Conversely, curcumin increased CD44 and decreased CD24 gene expression in MCF-7 breast cancer cells, and decreased CD44 gene expression in MDA-MB-231 cell line, while CD24 was not present in these cells.	Curcumin	12-20	CD44 molecule (Indian blood group)	Homo sapiens	115-119
29693159-13	2018	In conclusion, these results indicated that curcumin may be used to improve the proportion of CD44+/CD24+ cells and decrease the proportion of CD44+/CD24- cells.	Curcumin	44-52	CD44 molecule (Indian blood group)	Homo sapiens	94-98
29693159-13	2018	In conclusion, these results indicated that curcumin may be used to improve the proportion of CD44+/CD24+ cells and decrease the proportion of CD44+/CD24- cells.	Curcumin	44-52	CD44 molecule (Indian blood group)	Homo sapiens	143-147
30693689-6	2018	RESULTS: Compared with MPTP model group, curcumin increased the number of surviving dopamine neurons(P<0.01), decreased both protein expression and mRNA expression of alpha-Syn (all P<0.01), and increased protein expression of TFEB, LAMP2A and LC3-II (all P<0.01).	Curcumin	41-49	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	244-247
30693689-7	2018	When curcumin and 3-MA were given concurrently, the number of surviving dopamine neurons, protein expression of TFEB, LAMP2A and LC3-II increased (P<0.05 or P<0.01), and both protein expression and mRNA expression of alpha-Syn decreased (P<0.05 or P<0.01) compared with MPTP model group; but the number of surviving dopamine neurons and protein expression of LAMP2A and LC3-II decreased compared with curcumin group (all P<0.05).	Curcumin	5-13	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	129-132
30693689-7	2018	When curcumin and 3-MA were given concurrently, the number of surviving dopamine neurons, protein expression of TFEB, LAMP2A and LC3-II increased (P<0.05 or P<0.01), and both protein expression and mRNA expression of alpha-Syn decreased (P<0.05 or P<0.01) compared with MPTP model group; but the number of surviving dopamine neurons and protein expression of LAMP2A and LC3-II decreased compared with curcumin group (all P<0.05).	Curcumin	5-13	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	370-373
29568962-12	2018	In summary, curcumin may exert cardioprotective effects by up-regulating DKK-3, which in turn may inhibit p38 and JNK signaling pathways in an ASK1-dependent way.	Curcumin	12-20	dickkopf-related protein 3	Oryctolagus cuniculus	73-78
29700289-5	2018	Interestingly, we observed for the first time that curcumin attenuates RCP-induced ovarian cancer cell invasion by blocking stabilization of beta1 integrin and consequently inhibiting FAK and EGFR activation, providing potential biomarkers for ovarian cancer and therapeutic approaches for this deadly disease.	Curcumin	51-59	integrin subunit beta 1	Homo sapiens	141-155
30344245-7	2018	Results: The analysis of the co-localization between Golgi complex and ATP7B revealed that both 5 microM and 25 microM doses of curcumin improve the ability of liver cells to transport copper to plasma membrane at 20 microM CuCl2, but not at 100 microM CuCl2 concentration.	Curcumin	128-136	ATPase copper transporting beta	Homo sapiens	71-76
29662310-4	2018	Results: Both curcumin and curcumin/P pretreatment alleviated pathological morphological damage of myocardium, increased H2S and [Ca2+]i levels, and upregulated the expression of CaSR, CSE, and CaM as compared to DCM group, while curcumin/P remarkably augmented this effect.	Curcumin	14-22	calcium-sensing receptor	Rattus norvegicus	179-183
29662310-4	2018	Results: Both curcumin and curcumin/P pretreatment alleviated pathological morphological damage of myocardium, increased H2S and [Ca2+]i levels, and upregulated the expression of CaSR, CSE, and CaM as compared to DCM group, while curcumin/P remarkably augmented this effect.	Curcumin	27-35	calcium-sensing receptor	Rattus norvegicus	179-183
29662310-4	2018	Results: Both curcumin and curcumin/P pretreatment alleviated pathological morphological damage of myocardium, increased H2S and [Ca2+]i levels, and upregulated the expression of CaSR, CSE, and CaM as compared to DCM group, while curcumin/P remarkably augmented this effect.	Curcumin	27-35	calcium-sensing receptor	Rattus norvegicus	179-183
29420338-9	2018	After curcumin treatment, drug-resistant cell proliferation was significantly inhibited; in the curcumin+irinotecan treatment group, E-cadherin expression was upregulated, whereas vimentin and N-cadherin expressions were downregulated.	Curcumin	6-14	cadherin 2	Homo sapiens	193-203
29242172-5	2018	Curcumin up-regulated mRNA expression of genes involved in cholesterol transport and metabolism as ATP-binding cassette (ABC) transporters ABCA1 and ABCG1, and the sterol response element binding protein 1c (SREBP1c).	Curcumin	0-8	ATP binding cassette subfamily A member 1	Homo sapiens	139-144
29393445-7	2018	Inhibition of the JAK2/STAT3 signaling pathway, such as curcumin can reduce the expression of HMGB1 in brain tissue after cerebral ischemia, which can significantly reduce the inflammatory response after cerebral ischemia.	Curcumin	56-64	Janus kinase 2	Rattus norvegicus	18-22
29393445-7	2018	Inhibition of the JAK2/STAT3 signaling pathway, such as curcumin can reduce the expression of HMGB1 in brain tissue after cerebral ischemia, which can significantly reduce the inflammatory response after cerebral ischemia.	Curcumin	56-64	high mobility group box 1	Rattus norvegicus	94-99
29436680-0	2018	Curcumin increases cholesterol efflux via heme oxygenase-1-mediated ABCA1 and SR-BI expression in macrophages.	Curcumin	0-8	ATP binding cassette subfamily A member 1	Homo sapiens	68-73
29436680-0	2018	Curcumin increases cholesterol efflux via heme oxygenase-1-mediated ABCA1 and SR-BI expression in macrophages.	Curcumin	0-8	scavenger receptor class B member 1	Homo sapiens	78-83
29436680-11	2018	Curcumin also promoted scavenger receptor class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) expression.	Curcumin	0-8	scavenger receptor class B member 1	Homo sapiens	23-56
29436680-11	2018	Curcumin also promoted scavenger receptor class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) expression.	Curcumin	0-8	scavenger receptor class B member 1	Homo sapiens	58-63
29436680-11	2018	Curcumin also promoted scavenger receptor class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) expression.	Curcumin	0-8	ATP binding cassette subfamily A member 1	Homo sapiens	69-104
29436680-11	2018	Curcumin also promoted scavenger receptor class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) expression.	Curcumin	0-8	ATP binding cassette subfamily A member 1	Homo sapiens	106-111
29436680-12	2018	HO-1 small interfering (si)RNA partly abolished the increased SR-BI and ABCA1 expression induced by curcumin.	Curcumin	100-108	scavenger receptor class B member 1	Homo sapiens	62-67
29436680-12	2018	HO-1 small interfering (si)RNA partly abolished the increased SR-BI and ABCA1 expression induced by curcumin.	Curcumin	100-108	ATP binding cassette subfamily A member 1	Homo sapiens	72-77
29436680-16	2018	Overall, these data indicated that curcumin activates the Nrf2-ARE signaling pathway and upregulates HO-1 expression, which mediates SR-BI and ABCA1 expression and thereby increases cholesterol efflux.	Curcumin	35-43	scavenger receptor class B member 1	Homo sapiens	133-138
29552121-0	2018	Curcumin inhibits hepatocellular carcinoma growth by targeting VEGF expression.	Curcumin	0-8	vascular endothelial growth factor A	Mus musculus	63-67
29552121-9	2018	Furthermore, curcumin treatment significantly decreased VEGF expression and PI3K/AKT signaling.	Curcumin	13-21	vascular endothelial growth factor A	Mus musculus	56-60
29552121-10	2018	The present findings demonstrated that curcumin inhibited HCC proliferation in vitro and in vivo by reducing VEGF expression.	Curcumin	39-47	vascular endothelial growth factor A	Mus musculus	109-113
29325994-0	2018	The effects of melatonin and curcumin on the expression of SIRT2, Bcl-2 and Bax in the hippocampus of adult rats.	Curcumin	29-37	sirtuin 2	Rattus norvegicus	59-64
29325994-9	2018	RESULTS: Melatonin and curcumin significantly decreased MDA and SIRT2 expression in the hippocampus (p &lt; 0.05).	Curcumin	23-31	sirtuin 2	Rattus norvegicus	64-69
29599831-8	2018	Additionally, curcumin significantly inhibited the expression of p-Akt, p-Erk1/2, HIF-1alpha and VEGF in hypoxia-induced IGF-1R knockout HepG2 cells.	Curcumin	14-22	insulin like growth factor 1 receptor	Homo sapiens	121-127
29599831-9	2018	In conclusion, the findings of the present study suggest that curcumin may serve a pivotal role in tumor suppression via the inhibition of IGF-1R-mediated angiogenesis under hypoxic conditions.	Curcumin	62-70	insulin like growth factor 1 receptor	Homo sapiens	139-145
29328421-9	2018	Moreover, obvious autophagy was induced after curcumin-treatment, characterized by the formation of fluorescent particles [autophagic vesicles (AVs)] and significant increase in ratio of LC3-II/LC3-I and Beclin1 as well as decreased p62 expression.	Curcumin	46-54	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	187-190
29328421-9	2018	Moreover, obvious autophagy was induced after curcumin-treatment, characterized by the formation of fluorescent particles [autophagic vesicles (AVs)] and significant increase in ratio of LC3-II/LC3-I and Beclin1 as well as decreased p62 expression.	Curcumin	46-54	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	194-197
29328421-9	2018	Moreover, obvious autophagy was induced after curcumin-treatment, characterized by the formation of fluorescent particles [autophagic vesicles (AVs)] and significant increase in ratio of LC3-II/LC3-I and Beclin1 as well as decreased p62 expression.	Curcumin	46-54	beclin 1	Homo sapiens	204-211
29328421-9	2018	Moreover, obvious autophagy was induced after curcumin-treatment, characterized by the formation of fluorescent particles [autophagic vesicles (AVs)] and significant increase in ratio of LC3-II/LC3-I and Beclin1 as well as decreased p62 expression.	Curcumin	46-54	nucleoporin 62	Homo sapiens	233-236
29241692-1	2018	This study aimed to investigate the liver microsomal inhibitory effects of silybin, silychristin, andrographolide, and curcumin by using morphine as an in vitro UGT2B7 probe substrate, and predict the magnitude of the herb-drug interaction arising from these herbal constituents" inhibition in vivo.	Curcumin	119-127	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	161-167
29197967-12	2018	Curcumin induced a strong and significant reduction of all miR analyzed, except for has-miR-204, in both cell lines.	Curcumin	0-8	membrane associated ring-CH-type finger 8	Homo sapiens	59-62
29484272-14	2018	Moreover, curcumin treatment improved cell viability, reduced cell apoptosis, increased Bcl-2 protein levels while decreased Bax and caspase-3 expressions in mouse N2a cells after OGD/R injury.	Curcumin	10-18	BCL2-associated X protein	Mus musculus	125-128
29484272-14	2018	Moreover, curcumin treatment improved cell viability, reduced cell apoptosis, increased Bcl-2 protein levels while decreased Bax and caspase-3 expressions in mouse N2a cells after OGD/R injury.	Curcumin	10-18	caspase 3	Mus musculus	133-142
29484272-15	2018	Besides, curcumin treatment inhibited Bax activation and maintained mitochondrial membrane integrity.	Curcumin	9-17	BCL2-associated X protein	Mus musculus	38-41
29484272-17	2018	Moreover, our results for the first time demonstrated curcumin inhibited ischemia-induced mitochondrial apoptosis via restricting Bax activation, which may be one of the possible mechanisms underlying the neuroprotective effects of curcumin.	Curcumin	54-62	BCL2-associated X protein	Mus musculus	130-133
29484272-17	2018	Moreover, our results for the first time demonstrated curcumin inhibited ischemia-induced mitochondrial apoptosis via restricting Bax activation, which may be one of the possible mechanisms underlying the neuroprotective effects of curcumin.	Curcumin	232-240	BCL2-associated X protein	Mus musculus	130-133
29351226-7	2018	Inhibition of HO-1 attenuated the protective effect of curcumin on CCl4-induced acute liver injury.	Curcumin	55-63	chemokine (C-C motif) ligand 4	Mus musculus	67-71
29351226-8	2018	Given these outcomes, curcumin could protect against CCl4-induced acute liver injury by inhibiting oxidative stress and inflammation, which may partly involve the activation of Nrf2/HO-1 and inhibition of TGF-beta1/Smad3 pathways.	Curcumin	22-30	chemokine (C-C motif) ligand 4	Mus musculus	53-57
29277765-13	2018	DNA repair-related genes CCNH and XRCC5 were upregulated and LIG4 and PNKP downregulated by the combination of curcumin and irradiation compared with irradiation alone (p&lt;0.05).	Curcumin	111-119	polynucleotide kinase 3'-phosphatase	Homo sapiens	70-74
29277765-16	2018	Downregulation of LIG4 and PNKP and upregulation of XRCC5 and CCNH DNA-repair-related genes were involved in the radio-sensitizing efficacy of curcumin in colon cancer.	Curcumin	143-151	polynucleotide kinase 3'-phosphatase	Homo sapiens	27-31
29080451-9	2018	We also found curcumin sensitized CH12F3 lymphoma cells to DNA-PK and PARP inhibitors.	Curcumin	14-22	poly (ADP-ribose) polymerase family, member 1	Mus musculus	70-74
29080451-10	2018	Flow cytometry analysis showed curcumin promoted apoptosis and western blot analysis confirmed curcumin activated caspase3-dependent apoptosis.	Curcumin	95-103	caspase 3	Mus musculus	114-122
29080451-11	2018	Taken together, these results demonstrate that curcumin induces DNA damage through regulating Rad51-dependant homologous recombination and triggers caspase3-dependent apoptosis, more importantly, curcumin sensitizes lymphoma cells to various DNA damage drugs.	Curcumin	47-55	caspase 3	Mus musculus	148-156
29080451-11	2018	Taken together, these results demonstrate that curcumin induces DNA damage through regulating Rad51-dependant homologous recombination and triggers caspase3-dependent apoptosis, more importantly, curcumin sensitizes lymphoma cells to various DNA damage drugs.	Curcumin	196-204	caspase 3	Mus musculus	148-156
29132216-8	2017	Taken together, our data suggest that curcumin may play an important role in AD via reducing Caveolin-1, inactivating GSK-3[Formula: see text] and inhibiting the abnormal excessive phosphorylation of Tau, which will provide a new theory for AD treatment with curcumin.	Curcumin	38-46	caveolin 1, caveolae protein	Mus musculus	93-103
30636578-9	2018	In addition, our data showed that induction of oxidative stress and inhibition of angiogenesis through modulation of VEGF signaling regulatory miRNAs might be underlying mechanisms by which phytosomal curcumin exerted its antitumor effect.	Curcumin	201-209	vascular endothelial growth factor A	Mus musculus	117-121
29132216-8	2017	Taken together, our data suggest that curcumin may play an important role in AD via reducing Caveolin-1, inactivating GSK-3[Formula: see text] and inhibiting the abnormal excessive phosphorylation of Tau, which will provide a new theory for AD treatment with curcumin.	Curcumin	38-46	glycogen synthase kinase 3 beta	Mus musculus	118-123
29542427-9	2018	Meanwhile, all individual biomarkers showed no, less or moderate inhibitory effect towards all the tested CYP450 except for curcumin that showed inhibition of CYP2C8 (91%), CYP2C9 (81%) and CYP2C19 (72%) at 10microM.	Curcumin	124-132	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	190-197
29542427-10	2018	CONCLUSION: Curcumin was found to be an active constituent that might contribute to the inhibition of SynacinnTM against CYP2C8, CYP2C9 and CYP2C19.	Curcumin	12-20	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	140-147
29578162-3	2018	We demonstrated that curcumin inhibited activation of Akt-mTOR, ABL/STAT5 pathways, inhibited cell proliferation, and induced apoptosis in Ph + ALL cells.	Curcumin	21-29	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	64-67
29243061-9	2018	Curcumin in MCAO rats significantly improved brain damage and neurological function by upregulating p-Akt and p-mTOR and downregulating LC3-II/LC3-I, IL-1, TLR4, p-38, and p-p38.	Curcumin	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	112-116
27829579-7	2017	When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin.	Curcumin	47-55	vimentin	Homo sapiens	164-172
29243061-11	2018	Curcumin exerts neuroprotective effects by attenuating autophagic activities through mediating the PI3K/Akt/mTOR pathway, while also suppressing an inflammatory reaction by regulating the TLR4/p38/MAPK pathway.	Curcumin	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	108-112
27829579-7	2017	When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin.	Curcumin	66-74	vimentin	Homo sapiens	164-172
27829579-8	2017	Importantly, we found that curcumin reduced Akt, mTOR and P70S6K phosphorylation, effectively suppressing the activity of the Akt/mTOR pathway in HKCs.	Curcumin	27-35	ribosomal protein S6 kinase B1	Homo sapiens	58-64
29257220-0	2018	Curcumin improves diabetes mellitus-associated cerebral infarction by increasing the expression of GLUT1 and GLUT3.	Curcumin	0-8	solute carrier family 2 member 1	Homo sapiens	99-104
29257220-0	2018	Curcumin improves diabetes mellitus-associated cerebral infarction by increasing the expression of GLUT1 and GLUT3.	Curcumin	0-8	solute carrier family 2 member 3	Homo sapiens	109-114
28605332-3	2017	Against carbofuran, curcumin restored the activities of acetylcholinesterase, LDH, CK and gamma- GT in animals.	Curcumin	20-28	acetylcholinesterase	Rattus norvegicus	56-76
29257220-5	2018	However, following curcumin treatment, the levels of GLUT1 and GLUT3 were markedly increased.	Curcumin	19-27	solute carrier family 2 member 1	Homo sapiens	53-58
29257220-5	2018	However, following curcumin treatment, the levels of GLUT1 and GLUT3 were markedly increased.	Curcumin	19-27	solute carrier family 2 member 3	Homo sapiens	63-68
29257220-7	2018	To further evaluate whether curcumin prevented cell apoptosis by modulating the expression of GLUT1 and GLUT3, small interfering RNAs targeting GLUT1 and GLUT3 were selected.	Curcumin	28-36	solute carrier family 2 member 1	Homo sapiens	94-99
29257220-7	2018	To further evaluate whether curcumin prevented cell apoptosis by modulating the expression of GLUT1 and GLUT3, small interfering RNAs targeting GLUT1 and GLUT3 were selected.	Curcumin	28-36	solute carrier family 2 member 3	Homo sapiens	104-109
29257220-8	2018	It was found that the knockdown of GLUT1 and GLUT3 inhibited the abundance of GLUT1, GLUT3 and B-cell lymphoma 2, even following incubation with curcumin.	Curcumin	145-153	solute carrier family 2 member 1	Homo sapiens	35-40
29257220-8	2018	It was found that the knockdown of GLUT1 and GLUT3 inhibited the abundance of GLUT1, GLUT3 and B-cell lymphoma 2, even following incubation with curcumin.	Curcumin	145-153	solute carrier family 2 member 3	Homo sapiens	45-50
29085185-0	2017	Curcumin Attenuation of Wear Particle-Induced Osteolysis via RANKL Signaling Pathway Suppression in Mouse Calvarial Model.	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	61-66
29257220-8	2018	It was found that the knockdown of GLUT1 and GLUT3 inhibited the abundance of GLUT1, GLUT3 and B-cell lymphoma 2, even following incubation with curcumin.	Curcumin	145-153	solute carrier family 2 member 1	Homo sapiens	78-83
29257220-8	2018	It was found that the knockdown of GLUT1 and GLUT3 inhibited the abundance of GLUT1, GLUT3 and B-cell lymphoma 2, even following incubation with curcumin.	Curcumin	145-153	solute carrier family 2 member 3	Homo sapiens	85-90
29257220-9	2018	These data showed that curcumin protected brain cells from apoptosis and cerebral infarction, predominantly by upregulating GLUT1 and GLUT3.	Curcumin	23-31	solute carrier family 2 member 1	Homo sapiens	124-129
29257220-9	2018	These data showed that curcumin protected brain cells from apoptosis and cerebral infarction, predominantly by upregulating GLUT1 and GLUT3.	Curcumin	23-31	solute carrier family 2 member 3	Homo sapiens	134-139
27966075-0	2018	Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus Striatum.	Curcumin	21-29	brain-derived neurotrophic factor	Rattus norvegicus	44-48
29491534-0	2017	Curcumin modulation of the activation of PYK2 in peripheral blood mononuclear cells from patients with lupus nephritis.	Curcumin	0-8	protein tyrosine kinase 2 beta	Homo sapiens	41-45
29115468-6	2018	In addition, curcumin treatment significantly increased the protein expression of Keap1 in the Diab-Cur group when compared with the DC group, decreased cytosolic concentrations of Nrf2 while increasing nuclear accumulation of Nrf2.	Curcumin	13-21	Kelch-like ECH-associated protein 1	Rattus norvegicus	82-87
29115468-7	2018	The results provide evidence that oxidative stress in the STZ-induced diabetic rat model may be attenuated by curcumin via the activation of the Keap1-Nrf2-ARE signaling pathway, as evidenced by a decrease in the blood glucose concentration and an increase in the transcription of several antioxidant genes.	Curcumin	110-118	Kelch-like ECH-associated protein 1	Rattus norvegicus	145-150
29255221-8	2017	Western blot analysis revealed that curcumin up-regulated BRCA1, BRCA2 and ERCC1 expression in bone marrow.	Curcumin	36-44	breast cancer 1, early onset	Mus musculus	58-63
29285138-0	2017	Curcumin modulates covalent histone modification and TIMP1 gene activation to protect against vascular injury in a hypertension rat model.	Curcumin	0-8	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	53-58
29285138-9	2017	Furthermore, chromatin immunoprecipitation results suggested that curcumin was capable of promoting the transcription activation of TIMP1 through suppressing HDAC1 expression and increasing histone H3 acetylation at the TIMP1 promoter region in SHRs.	Curcumin	66-74	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	132-137
29491534-5	2017	Our aim was to investigate the mechanism of curcumin for management of LN, specifically regarding the PYK2 pathways.	Curcumin	44-52	protein tyrosine kinase 2 beta	Homo sapiens	102-106
29285138-9	2017	Furthermore, chromatin immunoprecipitation results suggested that curcumin was capable of promoting the transcription activation of TIMP1 through suppressing HDAC1 expression and increasing histone H3 acetylation at the TIMP1 promoter region in SHRs.	Curcumin	66-74	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	220-225
29491534-9	2017	Results: Curcumin inhibited the expression and activation of PYK2 in PBMCs in patients with LN in vitro.	Curcumin	9-17	protein tyrosine kinase 2 beta	Homo sapiens	61-65
28224816-9	2017	DISCUSSION AND CONCLUSION: Curcumin intake might reduce the risk of coronary heart disease by stimulating JAK2/STAT3 signal pathway, decreasing oxidative damage and inhibiting myocardium apoptosis.	Curcumin	27-35	Janus kinase 2	Rattus norvegicus	106-110
28826090-7	2017	Curcumin increased Nrf2 expression and nuclear translocation, and its binding activity to DNA, which might be associated with suppression of Kelch-like ECH-associated protein 1 in HSCs.	Curcumin	0-8	kelch-like ECH-associated protein 1	Mus musculus	141-176
28951138-7	2017	Moreover, curcumin significantly decreased oxidative stress and inflammation by determining the levels of malondialdehyde, manganese superoxide dismutase, glutathione peroxidase, catalase, IL-6 and TNF-alpha in skeletal muscle of COPD rats.	Curcumin	10-18	superoxide dismutase 2	Rattus norvegicus	123-153
29491534-11	2017	Curcumin also suppressed the expression of costimulatory molecules CD40L and CTLA-4, as well as PBMC proliferation.	Curcumin	0-8	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	77-83
29078859-0	2017	Corrigendum to "Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down-regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells" [J Nutr Biochem 44 (2017) 60-70].	Curcumin	16-24	C-X-C motif chemokine receptor 4	Homo sapiens	135-140
28901458-0	2017	Neuroprotective effects of curcumin alleviate lumbar intervertebral disc degeneration through regulating the expression of iNOS, COX-2, TGF-beta1/2, MMP-9 and BDNF in a rat model.	Curcumin	27-35	matrix metallopeptidase 9	Rattus norvegicus	136-154
29491534-13	2017	Conclusions: The inhibition of PYK2 signalling protein may be one of the mechanisms underlying the action of curcumin in LN treatment.	Curcumin	109-117	protein tyrosine kinase 2 beta	Homo sapiens	31-35
28901458-0	2017	Neuroprotective effects of curcumin alleviate lumbar intervertebral disc degeneration through regulating the expression of iNOS, COX-2, TGF-beta1/2, MMP-9 and BDNF in a rat model.	Curcumin	27-35	brain-derived neurotrophic factor	Rattus norvegicus	159-163
28901458-3	2017	The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, transforming growth factor (TGF)-beta1/2, matrix metalloproteinase (MMP)-9 and brain-derived neurotrophic factor (BDNF) in a rat model of LIDD.	Curcumin	56-64	matrix metallopeptidase 9	Rattus norvegicus	227-259
28000198-0	2016	[Study of the effect of LIG4 on the radiosensitivity enhancement of rectal cancer cells by curcumin].	Curcumin	91-99	DNA ligase 4	Homo sapiens	24-28
28901458-3	2017	The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, transforming growth factor (TGF)-beta1/2, matrix metalloproteinase (MMP)-9 and brain-derived neurotrophic factor (BDNF) in a rat model of LIDD.	Curcumin	56-64	brain-derived neurotrophic factor	Rattus norvegicus	264-297
28901458-3	2017	The aim of the present study was to investigate whether curcumin can alleviate LIDD through regulating the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, transforming growth factor (TGF)-beta1/2, matrix metalloproteinase (MMP)-9 and brain-derived neurotrophic factor (BDNF) in a rat model of LIDD.	Curcumin	56-64	brain-derived neurotrophic factor	Rattus norvegicus	299-303
28901458-5	2017	It was revealed that treatment with curcumin significantly reduced interleukin (IL)-1beta and IL-6, iNOS, COX-2 and MMP-9 levels in rats with LIDD.	Curcumin	36-44	matrix metallopeptidase 9	Rattus norvegicus	116-121
28901458-6	2017	In addition, treatment with curcumin reduced the mRNA expression levels of TGF-beta1 and TGF-beta2, whereas it increased the mRNA expression levels of BDNF in rats with LIDD.	Curcumin	28-36	brain-derived neurotrophic factor	Rattus norvegicus	151-155
28000198-1	2016	OBJECTIVE: To investigate the function of repair gene LIG4 in radiosensitivity enhancement of rectal cancer cells by curcumin.	Curcumin	117-125	DNA ligase 4	Homo sapiens	54-58
29048653-4	2017	In order to elucidate the mechanisms responsible for the overexpression of the XIAP protein in breast cancer, we attempted to clarify the mechanisms by which the natural compound curcumin downregulates XIAP in breast cancer cells.	Curcumin	179-187	X-linked inhibitor of apoptosis	Homo sapiens	79-83
28000198-9	2016	CONCLUSION: Down-regulation of LIG4 is an important mechanism of radiosensitivity enhancement of rectal cancer cells by curcumin.	Curcumin	120-128	DNA ligase 4	Homo sapiens	31-35
29048653-4	2017	In order to elucidate the mechanisms responsible for the overexpression of the XIAP protein in breast cancer, we attempted to clarify the mechanisms by which the natural compound curcumin downregulates XIAP in breast cancer cells.	Curcumin	179-187	X-linked inhibitor of apoptosis	Homo sapiens	202-206
29292884-0	2016	[JAK2/STAT3 signal pathway mediating curcumin in cartilage cell metabolism of osteoarthritis].	Curcumin	37-45	signal transducer and activator of transcription 3	Rattus norvegicus	6-11
29048653-5	2017	In that process, we identified the ribosomal protein S3 (RPS3) as a curcumin-binding protein using curcumin-fixed magnetic FG beads.	Curcumin	68-76	ribosomal protein S3	Homo sapiens	35-55
29048653-5	2017	In that process, we identified the ribosomal protein S3 (RPS3) as a curcumin-binding protein using curcumin-fixed magnetic FG beads.	Curcumin	68-76	ribosomal protein S3	Homo sapiens	57-61
29048653-5	2017	In that process, we identified the ribosomal protein S3 (RPS3) as a curcumin-binding protein using curcumin-fixed magnetic FG beads.	Curcumin	99-107	ribosomal protein S3	Homo sapiens	35-55
29292884-1	2016	OBJECTIVE: To observe influence of JAK2/STAT3 signal pathway mediating curcumin in cartilage cell metabolism of osteoarthritis and mitochondria oxidative stress resistance;also explore the role of JAK2/STAT3 signal pathway and effect of curcumin in this process.	Curcumin	71-79	signal transducer and activator of transcription 3	Rattus norvegicus	40-45
29048653-5	2017	In that process, we identified the ribosomal protein S3 (RPS3) as a curcumin-binding protein using curcumin-fixed magnetic FG beads.	Curcumin	99-107	ribosomal protein S3	Homo sapiens	57-61
29292884-1	2016	OBJECTIVE: To observe influence of JAK2/STAT3 signal pathway mediating curcumin in cartilage cell metabolism of osteoarthritis and mitochondria oxidative stress resistance;also explore the role of JAK2/STAT3 signal pathway and effect of curcumin in this process.	Curcumin	71-79	signal transducer and activator of transcription 3	Rattus norvegicus	202-207
28848967-14	2017	The expression of DEC1, HIF-1alpha, STAT3 and VEGF in tumor tissues was down-regulated after curcumin treatment.	Curcumin	93-101	vascular endothelial growth factor A	Mus musculus	46-50
29292884-1	2016	OBJECTIVE: To observe influence of JAK2/STAT3 signal pathway mediating curcumin in cartilage cell metabolism of osteoarthritis and mitochondria oxidative stress resistance;also explore the role of JAK2/STAT3 signal pathway and effect of curcumin in this process.	Curcumin	237-245	signal transducer and activator of transcription 3	Rattus norvegicus	40-45
28848967-15	2017	Our results indicate that curcumin inhibits the proliferation of gastric carcinoma by inducing the apoptosis of tumor cells, activating immune cells to secrete a large amount of cytokines, and down-regulating the DEC1, HIF-1alpha, VEGF and STAT3 signal transduction pathways.	Curcumin	26-34	vascular endothelial growth factor A	Mus musculus	231-235
29292884-5	2016	Compared with control group, p-JAK2, p-STAT3 protein expression was decreased in OA and curcumin with OA group(P&lt;0.05), Bax protein expression was increased (P&lt;0.05), SDA and COX protein expression were reduced (P&lt;0.05).	Curcumin	88-96	signal transducer and activator of transcription 3	Rattus norvegicus	39-44
28887914-10	2017	In vitro experiments showed that curcumin treatment directly decreased the Th1/Th2/Th17 cytokine production of IFN-gamma, IL-4, and IL-17A in CD4+ T cells.	Curcumin	33-41	interleukin 17A	Mus musculus	132-138
29292884-6	2016	Compared with OA group, p-JAK2, p-STAT3 protein expression was increased in curcumin with OA, Bax protein expression was decreased (P&lt;0.05), SDA and COX protein expression were increased (P&lt;0.05), and had statistical differences among three groups.	Curcumin	76-84	signal transducer and activator of transcription 3	Rattus norvegicus	34-39
28855623-3	2017	Oral PLGA-curcumin was at least as effective as native curcumin at a 15-fold lower concentration in preventing the breakdown of blood-brain barrier and inhibition of brain mRNAs for inflammatory cytokines, chemokine receptor CXCR3 and its ligand CXCL10, with an increase in the anti-inflammatory cytokine IL-10.	Curcumin	10-18	C-X-C motif chemokine ligand 10	Homo sapiens	246-252
27993021-0	2016	Curcumin-Loaded Amine-Functionalized Mesoporous Silica Nanoparticles Inhibit alpha-Synuclein Fibrillation and Reduce Its Cytotoxicity-Associated Effects.	Curcumin	0-8	synuclein alpha	Homo sapiens	77-92
28855623-3	2017	Oral PLGA-curcumin was at least as effective as native curcumin at a 15-fold lower concentration in preventing the breakdown of blood-brain barrier and inhibition of brain mRNAs for inflammatory cytokines, chemokine receptor CXCR3 and its ligand CXCL10, with an increase in the anti-inflammatory cytokine IL-10.	Curcumin	10-18	interleukin 10	Homo sapiens	305-310
28855623-5	2017	At equivalent concentrations, a single oral dose of PLGA-curcumin was more effective in inhibiting serum IFNgamma levels and enhancing IL-10 levels than native curcumin.	Curcumin	57-65	interleukin 10	Homo sapiens	135-140
28894373-6	2017	The expression of proliferating cell nuclear antigen (PCNA) was restored in the testis tissues of diabetic rats at the end of curcumin treatment.	Curcumin	126-134	proliferating cell nuclear antigen	Rattus norvegicus	54-58
27764939-7	2016	Further, activated Nrf2 by curcumin inhibited p53 expression in both livers and cultured hepatocytes under alcohol stimulation.	Curcumin	27-35	transformation related protein 53, pseudogene	Mus musculus	46-49
28774328-12	2017	Quantitative PCR confirmed the overexpression of VEGF-A and Ang-1 in EPCs after curcumin treatment.	Curcumin	80-88	vascular endothelial growth factor A	Mus musculus	49-55
27764939-8	2016	The next in vitro experiments, similar to in vivo ones, revealed that although Nrf2 knockdown abolished the suppression of curcumin on necroptosis of hepatocytes exposed to ethanol, p53 siRNA could clearly rescued the relative effect of curcumin.	Curcumin	237-245	transformation related protein 53, pseudogene	Mus musculus	182-185
28529240-4	2017	Mn-induced mitochondria-related apoptotic characteristics, such as caspase-3 and -9 activation, cytochrome c release, Bax increase, and Bcl-2 decrease, were significantly suppressed by curcumin.	Curcumin	185-193	caspase 3	Mus musculus	67-83
28529240-4	2017	Mn-induced mitochondria-related apoptotic characteristics, such as caspase-3 and -9 activation, cytochrome c release, Bax increase, and Bcl-2 decrease, were significantly suppressed by curcumin.	Curcumin	185-193	BCL2-associated X protein	Mus musculus	118-121
27764939-9	2016	In summary, for the first time, we concluded that curcumin attenuated alcohol-induced hepatocyte necroptosis in a Nrf2/p53-dependent mechanism.	Curcumin	50-58	transformation related protein 53, pseudogene	Mus musculus	119-122
28810635-0	2017	Curcumin protects against acute renal injury by suppressing JAK2/STAT3 pathway in severe acute pancreatitis in rats.	Curcumin	0-8	Janus kinase 2	Rattus norvegicus	60-64
28810635-8	2017	Furthermore, curcumin markedly decreased serum TNF-alpha and IL-6 levels and downregulated renal protein levels of JAK2/STAT3 pathway components.	Curcumin	13-21	Janus kinase 2	Rattus norvegicus	115-119
28595079-6	2017	Furthermore, curcumin markedly decreased NAD(P)H oxidase subunits (p67phox, p47phox, p22phox), nitrotyrosine and CYP2E1 renal protein expression as well as reduced pro-inflammatory cytokine expression (TNFalpha, IL-1beta, IFNgamma).	Curcumin	13-21	neutrophil cytosolic factor 2	Mus musculus	67-74
28053624-13	2016	Cancer cells treated with DM-2-8 and curcumin showed activation of caspase-9 and caspase-3 as downstream molecular components of the apoptotic pathway.	Curcumin	37-45	caspase 9	Homo sapiens	67-76
28595079-6	2017	Furthermore, curcumin markedly decreased NAD(P)H oxidase subunits (p67phox, p47phox, p22phox), nitrotyrosine and CYP2E1 renal protein expression as well as reduced pro-inflammatory cytokine expression (TNFalpha, IL-1beta, IFNgamma).	Curcumin	13-21	cytochrome b-245, alpha polypeptide	Mus musculus	85-92
28448872-7	2017	Furthermore, we found that curcumin up-regulated the expression of nuclear Nrf2 and Nrf2-dependent antioxidant defense genes including heme oxygenase-1 (HO-1), glutamate-cysteine ligase (GCLC), NAD(P)H dehydrogenase, and quinone (NQO-1) in a dose-dependent manner.	Curcumin	27-35	heme oxygenase 1	Rattus norvegicus	135-151
32707771-2	2020	Iron and the antioxidant curcumin have been shown to influence BDNF homeostasis.	Curcumin	25-33	brain derived neurotrophic factor	Homo sapiens	63-67
32707771-6	2020	The addition of curcumin to iron supplementation may therefore provide a novel approach to further enhance the benefits associated with increased BDNF levels.	Curcumin	16-24	brain derived neurotrophic factor	Homo sapiens	146-150
27000932-0	2016	In vivo effects of curcumin on the paraoxonase, carbonic anhydrase, glucose-6-phosphate dehydrogenase and beta-glucosidase enzyme activities in dextran sulphate sodium-induced ulcerative colitis mice.	Curcumin	19-27	glucose-6-phosphate dehydrogenase 2	Mus musculus	68-101
32721183-11	2020	Curcumin downregulated BECN1 and microtubule-associated protein 1 light chain 3 beta-II/I expression and upregulated p62 expression.	Curcumin	0-8	beclin 1	Homo sapiens	23-28
32721183-11	2020	Curcumin downregulated BECN1 and microtubule-associated protein 1 light chain 3 beta-II/I expression and upregulated p62 expression.	Curcumin	0-8	nucleoporin 62	Homo sapiens	117-120
32572733-0	2020	Curcumin attenuates IL-17A mediated pulmonary SMAD dependent and non-dependent mechanism during acute lung injury in vivo.	Curcumin	0-8	interleukin 17A	Mus musculus	20-26
28463091-8	2017	Curcumin (CCM) could rescue EMT process induced by gamma-irradiation via the suppression of Gli1 and the upregulation of Sufu.	Curcumin	0-8	GLI family zinc finger 1	Homo sapiens	92-96
28587210-4	2017	Curcumin treatment enhanced the expression of miR-98 and reduced that of the miR-98 target gene LIN28A as well as matrix metalloproteinase (MMP) 2 and MMP9 in vitro and in vivo.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	151-155
28587210-7	2017	Induction of miR-98 by curcumin treatment suppressed MMP2 and MMP9 by targeting LIN28A.	Curcumin	23-31	matrix metallopeptidase 9	Homo sapiens	62-66
32572733-4	2020	C57BL/6 mice were exposed to IL-17A and curcumin was administered as an intervention to modulate the IL-17A-induced alveolar damage.	Curcumin	40-48	interleukin 17A	Mus musculus	101-107
32572733-7	2020	Curcumin intervention in vivo promoted the resolution of IL-17A-induced ALI and attenuated pulmonary damage.	Curcumin	0-8	interleukin 17A	Mus musculus	57-63
27608133-10	2017	The key disease targets of leukemia namely tyrosine kinase (ABL1), aurora-like kinase (AUKRB), and polo-like kinase (PLK-2) showed that they had the comparable binding affinities of -9.7 k cal/mol, -8.7 k cal/mol, and -8.6 k cal/mol, respectively with curcumin.	Curcumin	252-260	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	60-64
27608133-10	2017	The key disease targets of leukemia namely tyrosine kinase (ABL1), aurora-like kinase (AUKRB), and polo-like kinase (PLK-2) showed that they had the comparable binding affinities of -9.7 k cal/mol, -8.7 k cal/mol, and -8.6 k cal/mol, respectively with curcumin.	Curcumin	252-260	polo like kinase 1	Homo sapiens	99-115
32572733-9	2020	Curcumin was found to block mRNA expressions of non- SMAD genes EGFR, JNK-1, JAK1, JAK2, STAT-1, STAT-3, MAPK14, also of TGF-beta1 and SMAD genes like SMAD 2, SMAD 3.	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	70-75
32572733-9	2020	Curcumin was found to block mRNA expressions of non- SMAD genes EGFR, JNK-1, JAK1, JAK2, STAT-1, STAT-3, MAPK14, also of TGF-beta1 and SMAD genes like SMAD 2, SMAD 3.	Curcumin	0-8	signal transducer and activator of transcription 1	Mus musculus	89-95
32572733-11	2020	Our study indicates that IL-17A participates in the development of ALI in both SMAD dependent and independent manner and the IL-17A signaling components were effectively controlled by curcumin, suggesting probable anti-inflammatory use of curcumin during ALI.	Curcumin	184-192	interleukin 17A	Mus musculus	125-131
32572733-11	2020	Our study indicates that IL-17A participates in the development of ALI in both SMAD dependent and independent manner and the IL-17A signaling components were effectively controlled by curcumin, suggesting probable anti-inflammatory use of curcumin during ALI.	Curcumin	239-247	interleukin 17A	Mus musculus	125-131
28238768-6	2017	Natural products such as resveratrol, berberine, and curcumin that are present in our diet, can trigger autophagy via canonical (Beclin-1-dependent) and non-canonical (Beclin-1-independent) pathways.	Curcumin	53-61	beclin 1	Homo sapiens	129-137
28238768-6	2017	Natural products such as resveratrol, berberine, and curcumin that are present in our diet, can trigger autophagy via canonical (Beclin-1-dependent) and non-canonical (Beclin-1-independent) pathways.	Curcumin	53-61	beclin 1	Homo sapiens	168-176
27000932-2	2016	Here we investigate whether prophylactic and therapeutic application of the curcumin alters the enzyme activities of paraoxonase (PON), carbonic anhydrase (CA), glucose-6-phosphate dehydrogenase (G6PD) and cytosolic beta-glucosidase in dextran sulphate sodium (DSS)-induced ulcerative colitis mice.	Curcumin	76-84	glucose-6-phosphate dehydrogenase 2	Mus musculus	161-194
28496336-0	2017	Curcumin exerts its antitumor activity through regulation of miR-7/Skp2/p21 in nasopharyngeal carcinoma cells.	Curcumin	0-8	leukocyte immunoglobulin like receptor B1	Homo sapiens	61-66
28496336-4	2017	In the current study, we set out to determine whether curcumin regulates miR-7 expression in nasopharyngeal carcinoma cells.	Curcumin	54-62	leukocyte immunoglobulin like receptor B1	Homo sapiens	73-78
28496336-6	2017	Importantly, we observed that curcumin upregulated the expression of miR-7 and subsequently inhibited Skp2, a direct miR-7 target.	Curcumin	30-38	leukocyte immunoglobulin like receptor B1	Homo sapiens	69-74
32151947-10	2020	In silico docking studies suggested Notch pathway genes (Notch-1, Hes-1 and Mib-1) as potential targets of BPA and curcumin.	Curcumin	115-123	MIB E3 ubiquitin protein ligase 1	Homo sapiens	76-81
27000932-2	2016	Here we investigate whether prophylactic and therapeutic application of the curcumin alters the enzyme activities of paraoxonase (PON), carbonic anhydrase (CA), glucose-6-phosphate dehydrogenase (G6PD) and cytosolic beta-glucosidase in dextran sulphate sodium (DSS)-induced ulcerative colitis mice.	Curcumin	76-84	glucose-6-phosphate dehydrogenase 2	Mus musculus	196-200
28496336-6	2017	Importantly, we observed that curcumin upregulated the expression of miR-7 and subsequently inhibited Skp2, a direct miR-7 target.	Curcumin	30-38	leukocyte immunoglobulin like receptor B1	Homo sapiens	117-122
28496336-7	2017	Our results identified that upregulation of miR-7 by curcumin could benefit nasopharyngeal carcinoma patients.	Curcumin	53-61	leukocyte immunoglobulin like receptor B1	Homo sapiens	44-49
28105222-0	2016	Curcumin suppresses the proliferation of gastric cancer cells by downregulating H19.	Curcumin	0-8	H19 imprinted maternally expressed transcript	Homo sapiens	80-83
28216009-4	2017	A clear induction of glutathione (GSH)-related antioxidant defenses was observed at 96h in the gills of curcumin exposed animals (10 and 30muM), including GSH levels, and the activity of glutathione reductase (GR), glutathione peroxidase (GPx), and glutathione S-transferase (GST).	Curcumin	104-112	Glutathione S-transferase	Crassostrea gigas	249-274
28216009-4	2017	A clear induction of glutathione (GSH)-related antioxidant defenses was observed at 96h in the gills of curcumin exposed animals (10 and 30muM), including GSH levels, and the activity of glutathione reductase (GR), glutathione peroxidase (GPx), and glutathione S-transferase (GST).	Curcumin	104-112	Glutathione S-transferase	Crassostrea gigas	276-279
28105222-3	2016	The aim of this study was to assess the role of H19 in curcumin-induced proliferative inhibition of gastric cancer.	Curcumin	55-63	H19 imprinted maternally expressed transcript	Homo sapiens	48-51
28339005-0	2017	Curcumin inhibits angiotensin II-induced inflammation and proliferation of rat vascular smooth muscle cells by elevating PPAR-gamma activity and reducing oxidative stress.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	121-131
28339005-3	2017	Curcumin (Cur) inhibits inflammatory responses by enhancing PPAR-gamma activity and reducing oxidative stress in various tissues.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	60-70
32521810-4	2020	The antioxidant curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-2,5-dione], glycosinolate of sulforaphane (broccoli) or AFA (Aphanizomenon flos) extract promote beneficial effects in patients.	Curcumin	16-24	AFA	Homo sapiens	132-135
28105222-7	2016	The protein expression of p53, B-cell lymphoma (Bcl)-2, Bcl-2-associated X protein (Bax) and c-Myc in curcumin-treated cells was detected by western blotting.	Curcumin	102-110	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	93-98
32472767-3	2020	Moreover, curcumin prevents HG induced increase in expression of CHOP, decrease in PCG-1a and phosphorylation of ERK1/2 (pERK1/2) without any effect on the phosphorylation levels of p38 and JNK.	Curcumin	10-18	mitogen-activated protein kinase 8	Mus musculus	190-193
28105222-8	2016	The present study demonstrated that curcumin inhibited the proliferation of SGC7901 cells and suppressed H19 expression in a concentration-dependent manner, while p53 expression was enhanced.	Curcumin	36-44	H19 imprinted maternally expressed transcript	Homo sapiens	105-108
32472295-4	2020	Meanwhile, curcumin decreased the level of cleaved caspase-3 and the release of TNF-alpha, IL-1beta, IL-6, but increased IL-10 release in LPS-treated BV2 cells.	Curcumin	11-19	caspase 3	Mus musculus	51-60
28105222-9	2016	Ectopic expression of H19 in SGC7901 cells reversed curcumin-induced proliferative inhibition and downregulated p53 expression.	Curcumin	52-60	H19 imprinted maternally expressed transcript	Homo sapiens	22-25
32278045-7	2020	According to literature, curcumin inhibits insulin-like growth factor 1 (IGF-1)/phosphoinositide 3-kinase (PI3K)/Akt/mTORC1 pathway which leads to apoptosis and cell cycle arrest via suppression of erythroblastosis virus transcription factor 2 and murine double minute 2 oncoprotein.	Curcumin	25-33	HNF1 homeobox B	Mus musculus	221-243
27715343-0	2017	Curcumin reduces lung inflammation via Wnt/beta-catenin signaling in mouse model of asthma.	Curcumin	0-8	catenin (cadherin associated protein), beta 1	Mus musculus	43-55
27853364-13	2016	Curcumin downregulated the expression of MCP-1, IL-8, and MIP-2alpha, and the expression was further enhanced in the presence of corticosteroid.	Curcumin	0-8	C-C motif chemokine ligand 2	Rattus norvegicus	41-46
27715343-3	2017	Researchers reported that curcumin regulated Wnt/beta-catenin signaling in lots of cells.	Curcumin	26-34	catenin (cadherin associated protein), beta 1	Mus musculus	49-61
27715343-4	2017	However, whether curcumin regulates the levels of Wnt/beta-Catenin signaling in lung tissues and DCs (dendritic cells) remains unclear.	Curcumin	17-25	catenin (cadherin associated protein), beta 1	Mus musculus	54-66
27715343-14	2017	Curcumin activated Wnt/beta-catenin signaling pathway in DCs and asthmatic mouse lungs.	Curcumin	0-8	catenin (cadherin associated protein), beta 1	Mus musculus	23-35
27715343-15	2017	CONCLUSIONS: Curcumin could influence the morphology and function of DCs, ease asthma symptom and inflammatory reaction through the activation of Wnt/beta-catenin signaling.	Curcumin	13-21	catenin (cadherin associated protein), beta 1	Mus musculus	150-162
28387563-0	2017	Curcumin Upregulates Antioxidant Defense, Lon Protease, and Heat-Shock Protein 70 Under Hyperglycemic Conditions in Human Hepatoma Cells.	Curcumin	0-8	heat shock protein family A (Hsp70) member 4	Homo sapiens	60-81
32547215-0	2020	Curcumin Affects Gastric Cancer Cell Migration, Invasion and Cytoskeletal Remodeling Through Gli1-beta-Catenin.	Curcumin	0-8	GLI family zinc finger 1	Homo sapiens	93-97
32547215-5	2020	Results: We show that curcumin suppressed the expression of Shh, Gli1 and Foxm1 in the Shh signaling pathway, and the expression of beta-catenin in the Wnt signaling pathway in SGC-7901 cells, both in mRNA and protein.	Curcumin	22-30	GLI family zinc finger 1	Homo sapiens	65-69
32547215-5	2020	Results: We show that curcumin suppressed the expression of Shh, Gli1 and Foxm1 in the Shh signaling pathway, and the expression of beta-catenin in the Wnt signaling pathway in SGC-7901 cells, both in mRNA and protein.	Curcumin	22-30	forkhead box M1	Homo sapiens	74-79
32547215-11	2020	Conclusion: The present study indicated that curcumin plays an anti-tumor role through Gli1-beta-catenin pathway in gastric cancer SGC-7901 cells.	Curcumin	45-53	GLI family zinc finger 1	Homo sapiens	87-91
27645308-0	2016	Revealing the effect of 6-gingerol, 6-shogaol and curcumin on mPGES-1, GSK-3beta and beta-catenin pathway in A549 cell line.	Curcumin	50-58	prostaglandin E synthase	Mus musculus	62-69
32124251-4	2020	Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	150-155
32124251-4	2020	Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment.	Curcumin	0-8	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	179-187
32124251-4	2020	Curcumin treatment inhibited the expression of the inflammation mediators IL-6, iNOS, and COX-2 and of the matrix-degrading proteinases MMP-1, MMP-3, MMP-9, MMP-13, ADAMTS-4, and ADAMTS-5 and upregulated the mRNA levels of the cartilage anabolic factors COL2A1 and ACAN after IL-1beta treatment.	Curcumin	0-8	aggrecan	Homo sapiens	265-269
27003823-0	2017	Curcumin Rescues a PINK1 Knock Down SH-SY5Y Cellular Model of Parkinson"s Disease from Mitochondrial Dysfunction and Cell Death.	Curcumin	0-8	PTEN induced kinase 1	Homo sapiens	19-24
27003823-4	2017	The aim of the present study was to create a cellular model of PD using siRNA-mediated knock down of PINK1 in SH-SY5Y neuroblastoma cells The possible protective effects of curcumin, known for its many beneficial properties including antioxidant and anti-inflammatory effects, was tested on this model in the presence and absence of paraquat, an additional stressor.	Curcumin	173-181	PTEN induced kinase 1	Homo sapiens	101-106
31909882-0	2020	Blockade of high mobility group box 1 involved in the protective of curcumin on myocardial injury in diabetes in vivo and in vitro.	Curcumin	68-76	high mobility group box 1	Rattus norvegicus	12-37
27645308-20	2016	CONCLUSION: We saw that 6-shogaol is as effective as curcumin on this pathway and our study shows that 6-shogaol might show its anticancer properties via mPGES-1 and GSK3beta pathway.	Curcumin	53-61	prostaglandin E synthase	Mus musculus	154-161
31909882-9	2020	HMGB1 inhibitor or HMGB1 knockdown counteracted the effects of Cu on diabetic cardiomyopathy.	Curcumin	63-65	high mobility group box 1	Rattus norvegicus	0-5
31909882-9	2020	HMGB1 inhibitor or HMGB1 knockdown counteracted the effects of Cu on diabetic cardiomyopathy.	Curcumin	63-65	high mobility group box 1	Rattus norvegicus	19-24
28579878-8	2017	Compared with the model group, groups treated with the metformin and with different proportions of astragaloside and curcumin help lower the blood glucose levels and GSP levels, increase glycogen stores of model mice by different degrees, and avoid pathological changes of pancreas in the model mice.	Curcumin	117-125	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	166-169
27763524-9	2016	In conclusion, compared with curcumin, a solid dispersion formulation of curcumin with TPGS and mannitol could be a promising option for enhancing the oral bioavailability and efficacy of curcumin through increased solubility, dissolution rate, cell permeability, and P-gp modulation.	Curcumin	73-81	phosphoglycolate phosphatase	Homo sapiens	268-272
28579878-11	2017	The ratio of total astragaloside and curcumin can lower blood glucose levels, GSP levels, promote the formation of glycogen, and improve the pathological changes of pancreas in the model mice.	Curcumin	37-45	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	78-81
28439402-0	2017	Upregulation of heme oxygenase-1 expression by curcumin conferring protection from hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblasts.	Curcumin	47-55	heme oxygenase 1	Rattus norvegicus	16-32
31909882-10	2020	The present study showed the protective effects of Cu on myocardial injury via HMGB1 pathway in diabetic cardiomyopathy in vivo and in vitro.	Curcumin	51-53	high mobility group box 1	Rattus norvegicus	79-84
32627518-0	2020	Long noncoding RNA GAS5 enhanced by curcumin relieves poststroke depression by targeting miR-10b/BDNF in rats.	Curcumin	36-44	growth arrest specific 5	Rattus norvegicus	19-23
32627518-0	2020	Long noncoding RNA GAS5 enhanced by curcumin relieves poststroke depression by targeting miR-10b/BDNF in rats.	Curcumin	36-44	brain-derived neurotrophic factor	Rattus norvegicus	97-101
28439402-4	2017	Exposure of cells with curcumin caused a dose-dependent induction of heme oxygenase-1 (HO-1) protein expression.	Curcumin	23-31	heme oxygenase 1	Rattus norvegicus	69-85
27763524-9	2016	In conclusion, compared with curcumin, a solid dispersion formulation of curcumin with TPGS and mannitol could be a promising option for enhancing the oral bioavailability and efficacy of curcumin through increased solubility, dissolution rate, cell permeability, and P-gp modulation.	Curcumin	73-81	phosphoglycolate phosphatase	Homo sapiens	268-272
28439402-4	2017	Exposure of cells with curcumin caused a dose-dependent induction of heme oxygenase-1 (HO-1) protein expression.	Curcumin	23-31	heme oxygenase 1	Rattus norvegicus	87-91
28439402-6	2017	ZnPP-IX, a HO-1 inhibitor, partly reversed the anti-apoptotic effect of curcumin.	Curcumin	72-80	heme oxygenase 1	Rattus norvegicus	11-15
32627518-4	2020	Furthermore, long noncoding RNA growth arrest-specific transcript 5 (GAS5) enhanced by curcumin contributed to activation of the BDNF/Trkbeta signaling pathway to promote the expression of synaptic-related proteins.	Curcumin	87-95	growth arrest specific 5	Rattus norvegicus	32-67
32627518-4	2020	Furthermore, long noncoding RNA growth arrest-specific transcript 5 (GAS5) enhanced by curcumin contributed to activation of the BDNF/Trkbeta signaling pathway to promote the expression of synaptic-related proteins.	Curcumin	87-95	growth arrest specific 5	Rattus norvegicus	69-73
32627518-4	2020	Furthermore, long noncoding RNA growth arrest-specific transcript 5 (GAS5) enhanced by curcumin contributed to activation of the BDNF/Trkbeta signaling pathway to promote the expression of synaptic-related proteins.	Curcumin	87-95	brain-derived neurotrophic factor	Rattus norvegicus	129-133
32627518-4	2020	Furthermore, long noncoding RNA growth arrest-specific transcript 5 (GAS5) enhanced by curcumin contributed to activation of the BDNF/Trkbeta signaling pathway to promote the expression of synaptic-related proteins.	Curcumin	87-95	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	134-141
28439402-7	2017	Further, LY294002, an inhibitor of PI3K, partially reversed the effect of curcumin on HO-1 protein induction, leading to the attenuation of curcumin-mediated apoptosis resistance.	Curcumin	74-82	heme oxygenase 1	Rattus norvegicus	86-90
28439402-7	2017	Further, LY294002, an inhibitor of PI3K, partially reversed the effect of curcumin on HO-1 protein induction, leading to the attenuation of curcumin-mediated apoptosis resistance.	Curcumin	140-148	heme oxygenase 1	Rattus norvegicus	86-90
28439402-8	2017	CONCLUSION: These results demonstrated that the anti-apoptotic function of curcumin required the upregulation of HO-1 protein through the PI3K/Akt signaling pathway.	Curcumin	75-83	heme oxygenase 1	Rattus norvegicus	113-117
27777559-7	2016	Curcumin also markedly inhibited the upregulation of toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), phosphorylation level of IkappaB-alpha, and activation of NF-kappaB in PMA-induced macrophages.	Curcumin	0-8	toll like receptor 4	Homo sapiens	53-73
28336111-0	2017	Hepatoprotective effects of curcumin in rats after bile duct ligation via downregulation of Rac1 and NOX1.	Curcumin	28-36	NADPH oxidase 1	Rattus norvegicus	101-105
28336111-2	2017	The aim of this study was to investigate the protective effect of curcumin on hepatic damage by measuring the antioxidant capacity and expression level of Rho-related C3 botulinum toxin substrate (Rac1), Rac1-Guanosine triphosphate (Rac1-GTP), and NADPH oxidase 1(NOX1) in biliary duct-ligated (BDL)-fibrotic rat model.	Curcumin	66-74	NADPH oxidase 1	Rattus norvegicus	248-263
28336111-2	2017	The aim of this study was to investigate the protective effect of curcumin on hepatic damage by measuring the antioxidant capacity and expression level of Rho-related C3 botulinum toxin substrate (Rac1), Rac1-Guanosine triphosphate (Rac1-GTP), and NADPH oxidase 1(NOX1) in biliary duct-ligated (BDL)-fibrotic rat model.	Curcumin	66-74	NADPH oxidase 1	Rattus norvegicus	264-268
27777559-7	2016	Curcumin also markedly inhibited the upregulation of toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), phosphorylation level of IkappaB-alpha, and activation of NF-kappaB in PMA-induced macrophages.	Curcumin	0-8	toll like receptor 4	Homo sapiens	75-79
32627518-6	2020	GAS5 upregulation by curcumin could reduce miR-10b to compromise the BDNF mRNA levels.	Curcumin	21-29	growth arrest specific 5	Rattus norvegicus	0-4
32627518-6	2020	GAS5 upregulation by curcumin could reduce miR-10b to compromise the BDNF mRNA levels.	Curcumin	21-29	brain-derived neurotrophic factor	Rattus norvegicus	69-73
27777559-11	2016	Conclusion: Curcumin inhibited NLRP3 inflammasome through suppressing TLR4/MyD88/NF-kappaB and P2X7R pathways in PMA-induced macrophages.	Curcumin	12-20	toll like receptor 4	Homo sapiens	70-74
32627518-7	2020	Taken together, these results revealed a novel mechanism of curcumin on PSD through the GAS5/miR-10b/BDNF regulatory axis.	Curcumin	60-68	growth arrest specific 5	Rattus norvegicus	88-92
32627518-7	2020	Taken together, these results revealed a novel mechanism of curcumin on PSD through the GAS5/miR-10b/BDNF regulatory axis.	Curcumin	60-68	brain-derived neurotrophic factor	Rattus norvegicus	101-105
27580989-9	2016	The ERK1/2 and SAPK/JNK and their downstream molecules including P90RSK and c-Jun, respectively, were activated by curcumin.	Curcumin	115-123	ribosomal protein S6 kinase A1	Homo sapiens	65-71
32124937-7	2020	However, APE1 knockdown by siRNA transfection markedly abrogated the protective effects of curcumin against OGD/R-induced cytotoxicity, apoptosis and oxidative stress, as illustrated by the decreases in reactive oxygen species production and NADPH oxidase 2 expression, and the increase in superoxide dismutase activity and glutathione levels in SH-SY5Y cells.	Curcumin	91-99	cytochrome b-245 beta chain	Homo sapiens	242-257
28443468-0	2017	Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction.	Curcumin	0-8	metastasis associated 1	Homo sapiens	115-119
27423629-6	2016	Our data also showed that curcumin inhibits oxidative stress-induced cytoskeleton disarrangement, and impedes the activation of astrocytes by inhibiting upregulation of GFAP, vimentin and Prdx6.	Curcumin	26-34	vimentin	Homo sapiens	175-183
28443468-6	2017	Mechanically, the study revealed that Curcumin could reduce the expression of metastasis-associated gene 1 (MTA1) gene through upregulation of microRNA-30c in Paclitaxel-resistant non-small-cell lung cancer cells.	Curcumin	38-46	metastasis associated 1	Homo sapiens	78-112
28443468-8	2017	Taken together, our studies indicate that Curcumin increases the sensitivity of Paclitaxel-resistant non-small-cell lung cancer cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction.	Curcumin	42-50	metastasis associated 1	Homo sapiens	178-182
27297718-9	2016	Metaanalysis suggested that curcumin supplementation can increase adiponectin levels by 76.78% (95% CI: 6.14-147.42; P = 0.0330), and reduce leptin by 26.49% (95% CI: -70.44 to 17.46), however this latter effect size did not reach statistical significance (P = 0.238).	Curcumin	28-36	leptin	Homo sapiens	141-147
27297718-10	2016	CONCLUSIONS: Curcumin can improve serum levels of adiponectin and leptin in patients with metabolic syndrome.	Curcumin	13-21	leptin	Homo sapiens	66-72
28280340-1	2017	Curcumin (CRM) and nerve growth factor (NGF) were entrapped in liposomes (LIP) with surface wheat germ agglutinin (WGA) to downregulate the phosphorylation of kinases in Alzheimer"s disease (AD) therapy.	Curcumin	0-8	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	74-77
27572503-13	2016	In addition, the H2O2-induced elevation of p-ERK and p-NF-kappaB in BxPC-3 and Panc-1 cells were reduced by curcumin, NAC and PD 98059 (an ERK inhibitor).	Curcumin	108-116	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	43-48
28095363-0	2017	Curcumin confers neuroprotection against alcohol-induced hippocampal neurodegeneration via CREB-BDNF pathway in rats.	Curcumin	0-8	brain-derived neurotrophic factor	Rattus norvegicus	96-100
28095363-18	2017	CONCLUSION: Curcumin can act as a neuroprotective agent against neurodegenerative effects of alcohol abuse, probably via activation of CREB-BDNF signaling pathway.	Curcumin	12-20	brain-derived neurotrophic factor	Rattus norvegicus	140-144
27564099-6	2016	NAC(ROS scavenger) and U0126(ERK inhibitor) inhibited apoptosis induced by curcumin and cisplatin.	Curcumin	75-83	synuclein alpha	Homo sapiens	0-3
27677346-0	2017	Curcumin synergistically increases effects of beta-interferon and retinoic acid on breast cancer cells in vitro and in vivo by up-regulation of GRIM-19 through STAT3-dependent and STAT3-independent pathways.	Curcumin	0-8	NADH:ubiquinone oxidoreductase subunit A13	Homo sapiens	144-151
27677346-1	2017	OBJECTIVE: The study aimed to investigate the effects of combination treatment of curcumin and beta-interferon (IFN-beta)/retinoic acid (RA) on breast cancer cells, including cell viability, apoptosis and migration, and to determine the mechanisms related to GRIM-19 through STAT3-dependent and STAT3-independent pathways.	Curcumin	82-90	NADH:ubiquinone oxidoreductase subunit A13	Homo sapiens	259-266
27564099-7	2016	In addition, when 253J-Bv cells were co-treated with curcumin and cisplatin, p53 and p21 expression levels were markedly increased when compared to controls.	Curcumin	53-61	H3 histone pseudogene 16	Homo sapiens	85-88
28239299-12	2017	SIGNIFICANCE: DK1 was found to be more effective in inducing cell cycle arrest and apoptosis against MCF-7 cell with much higher selectivity index of MCF-10A/MCF-7 than curcumin, which might be contributed by the overexpression of p53 protein.	Curcumin	169-177	immunoglobulin heavy diversity 5-12	Homo sapiens	14-17
27381867-0	2016	Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: Possible involvement of ROS and thioredoxin reductase.	Curcumin	9-17	peroxiredoxin 5	Homo sapiens	142-163
28165402-6	2017	Moreover, we observed that curcumin significantly inhibited the expression of Cdc20 in pancreatic cancer cells.	Curcumin	27-35	cell division cycle 20	Homo sapiens	78-83
28165402-7	2017	Furthermore, our results demonstrated that overexpression of Cdc20 enhanced cell proliferation and invasion, and abrogated the cytotoxic effects induced by curcumin in pancreatic cancer cells.	Curcumin	156-164	cell division cycle 20	Homo sapiens	61-66
28165402-8	2017	Consistently, downregulation of Cdc20 promoted curcumin-mediated anti-tumor activity.	Curcumin	47-55	cell division cycle 20	Homo sapiens	32-37
27375190-8	2016	These results indicate that curcumin could effectively inhibit QCT induced apoptosis and inflammatory response in L02 cells, which may involve the activation of Nrf2/HO-1 and inhibition of NF-kB pathway.	Curcumin	28-36	heme oxygenase 1	Homo sapiens	166-170
28165402-9	2017	Therefore, our findings indicated that inhibition of Cdc20 by curcumin could be useful for the treatment of pancreatic cancer patients.	Curcumin	62-70	cell division cycle 20	Homo sapiens	53-58
28179291-9	2017	AS-IV and curcumin alone up-regulated expression of miR-122 and down-regulated that of miR-221.	Curcumin	10-18	microRNA 122	Homo sapiens	52-59
27573203-7	2016	Results showed that curcumin decreased E-cadherin, N-cadherin, beta-catenin, Slug, AXL, Twist1, Vimentin and Fibronectin protein expression, independently of the positivity of the markers in the cell lines.	Curcumin	20-28	AXL receptor tyrosine kinase	Mus musculus	83-86
28118809-8	2017	Additionally, our results revealed that curcumin alleviated INH/RFP-induced liver injury, declined PPIX levels and induced FECH expression in both L-02 cells and mice.	Curcumin	40-48	ferrochelatase	Homo sapiens	123-127
27573203-7	2016	Results showed that curcumin decreased E-cadherin, N-cadherin, beta-catenin, Slug, AXL, Twist1, Vimentin and Fibronectin protein expression, independently of the positivity of the markers in the cell lines.	Curcumin	20-28	fibronectin 1	Mus musculus	109-120
27556439-5	2016	In addition, curcumin pre-treatment significantly ameliorated the loss of mitochondrial membrane potential, the activations of caspase-9 and -3, and apoptosis caused by FZD.	Curcumin	13-21	caspase 9	Homo sapiens	127-143
27746419-5	2017	The outcome of this study might provide the first scientific basis for explaining why a wide variety of herbal PAK1-blockers such as CAPE (caffeic acid phenethyl ester), curcumin and shikonin in cosmetics are useful for skin-whitening.	Curcumin	170-178	p21 (RAC1) activated kinase 1	Mus musculus	111-115
27556439-7	2016	Curcumin pre-treatment consistently and markedly down-regulated the mRNA expression levels of p53, Bax, caspase-9 and -3 and up-regulated the mRNA expression level of Bcl-2.	Curcumin	0-8	caspase 9	Homo sapiens	104-120
28077837-7	2017	Curcumin significantly suppressed the levels of Wnt3a, LRP6, phospho-LRP6, beta-catenin, phospho-beta-catenin, C-myc, and survivin.	Curcumin	0-8	LDL receptor related protein 6	Homo sapiens	55-59
28077837-7	2017	Curcumin significantly suppressed the levels of Wnt3a, LRP6, phospho-LRP6, beta-catenin, phospho-beta-catenin, C-myc, and survivin.	Curcumin	0-8	LDL receptor related protein 6	Homo sapiens	69-73
27594837-4	2016	Here, using both APP/PS1 transgenic mice and beta-amyloid-induced neuroinflammation in mixed neuronal/glial cultures, we showed that curcumin significantly alleviated spatial memory deficits in APP/PS1 mice and promoted cholinergic neuronal function in vivo and in vitro.	Curcumin	133-141	presenilin 1	Mus musculus	21-24
28249909-6	2017	Data mining of the National Library of Medicine"s MEDLINE Database and Ingenuity Pathway analysis revealed agents of relatively low toxicity-melatonin, metformin, curcumin and sulforaphane-that are capable of inhibiting directly or pharmacogenomically one or both of the SIRT1 and EZH2 pathways and should, in a combinatorial fashion, remove the block in differentiation and decrease the proliferation of the B-cell ALL lymphoblasts.	Curcumin	163-171	sirtuin 1	Homo sapiens	271-276
28340987-0	2017	Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents.	Curcumin	19-27	xanthine dehydrogenase	Mus musculus	50-66
27594837-4	2016	Here, using both APP/PS1 transgenic mice and beta-amyloid-induced neuroinflammation in mixed neuronal/glial cultures, we showed that curcumin significantly alleviated spatial memory deficits in APP/PS1 mice and promoted cholinergic neuronal function in vivo and in vitro.	Curcumin	133-141	presenilin 1	Mus musculus	198-201
28340987-1	2017	A series of curcumin derivatives as potent dual inhibitors of xanthine oxidase (XOD) and urate transporter 1 (URAT1) was discovered as anti-hyperuricemic agents.	Curcumin	12-20	xanthine dehydrogenase	Mus musculus	62-78
27540290-0	2016	A dual brain-targeting curcumin-loaded polymersomes ameliorated cognitive dysfunction in intrahippocampal amyloid-beta1-42-injected mice.	Curcumin	23-31	hemoglobin, beta adult major chain	Mus musculus	114-119
28340987-1	2017	A series of curcumin derivatives as potent dual inhibitors of xanthine oxidase (XOD) and urate transporter 1 (URAT1) was discovered as anti-hyperuricemic agents.	Curcumin	12-20	xanthine dehydrogenase	Mus musculus	80-83
28478460-0	2017	Curcumin Inhibits Heat-Induced Apoptosis by Suppressing NADPH Oxidase 2 and Activating the Akt/mTOR Signaling Pathway in Bronchial Epithelial Cells.	Curcumin	0-8	cytochrome b-245 beta chain	Homo sapiens	56-71
28478460-12	2017	Administration of curcumin significantly inhibited apoptosis of 16HBE140 cells and suppressed the membrane translocation of NADPH oxidase 2 cytosolic components, as well as ROS production.	Curcumin	18-26	cytochrome b-245 beta chain	Homo sapiens	124-139
28478460-16	2017	CONCLUSION: This study demonstrates that one of the critical mechanisms underlying curcumin inhibiting heat-induced apoptosis is through suppressing NADPH Oxidase 2 and activating the Akt/mTOR signaling pathway in bronchial epithelial cells.	Curcumin	83-91	cytochrome b-245 beta chain	Homo sapiens	149-164
29065403-6	2017	RESULTS: Our results indicated that Curcumin-NP reversed oxidative stress, growth inhibition and cell apoptosis accompanied with down-regulation of apoptotic markers Caspase-3 and GRP-78 in vitro.	Curcumin	36-44	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	180-186
29065403-8	2017	In addition, kidney tissues from Curcumin-NP-treated AKI rats exhibited reduced oxidative stress, apoptosis, and cleaved Capase-3 and GRP-78 expression.	Curcumin	33-41	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	134-140
28067164-7	2017	Recent studies have documented that pharmacological effects of curcumin in lung cancer are also mediated by modulation of several miRNAs, such as downregulation of oncogenic miR-21 and upregulation of oncosuppressive miR-192-5p and miR-215.	Curcumin	63-71	microRNA 215	Homo sapiens	232-239
27540290-6	2016	The curcumin-encapsulated Tf/Tet-1-POs provided neuroprotection and ameliorated cognitive dysfunction in intrahippocampal amyloid-beta1-42-injected mice.	Curcumin	4-12	hemoglobin, beta adult major chain	Mus musculus	130-135
27403579-3	2016	Turbidity measurement reveals that the presence of curcumin increases the NaC concentration for the solubilization of phospholipid vesicles, which indicates that the bound curcumin tends to suppress the vesicle-to-micelle transition.	Curcumin	51-59	synuclein alpha	Homo sapiens	74-77
30645874-1	2017	The purpose of the study was to determine the effects of curcumin (CUR) and quercetin (QUER) on the expression of genes and activity of prototypical Nrf2/ARE- and AhR/ XRE-regulated enzymes.	Curcumin	57-65	aryl hydrocarbon receptor	Rattus norvegicus	154-166
29292884-7	2016	CONCLUSIONS: JAK2/STAT3 signal pathway is closely associated with pathology course of osteoarthritis, curcumin could stimulate JAK2/STAT3 signal pathway and promote mitochondria oxidative stress.	Curcumin	102-110	Janus kinase 2	Rattus norvegicus	13-17
29292884-7	2016	CONCLUSIONS: JAK2/STAT3 signal pathway is closely associated with pathology course of osteoarthritis, curcumin could stimulate JAK2/STAT3 signal pathway and promote mitochondria oxidative stress.	Curcumin	102-110	Janus kinase 2	Rattus norvegicus	127-131
27466310-7	2016	After the administration of curcumin for 6 months, the results showed that the expression of an insulin receptor (InR) and insulin receptor substrate (IRS)-1 decreased in the hippocampal CA1 area of the APPswe/PS1dE9 double transgenic mice, while the expression of phosphatidylinositol-3 kinase (PI3K), phosphorylated PI3K (p-PI3K), serine-threonine kinase (AKT) and phosphorylated AKT (p-AKT) increased.	Curcumin	28-36	mitogen-activated protein kinase kinase kinase 10	Mus musculus	333-356
27403579-3	2016	Turbidity measurement reveals that the presence of curcumin increases the NaC concentration for the solubilization of phospholipid vesicles, which indicates that the bound curcumin tends to suppress the vesicle-to-micelle transition.	Curcumin	172-180	synuclein alpha	Homo sapiens	74-77
27403579-4	2016	The pyrene polarity index and curcumin fluorescence anisotropy measurements suggest that phospholipid/NaC mixed micelles have a more compact structure than that of phospholipid vesicles and phospholipid/NaC mixed vesicles.	Curcumin	30-38	synuclein alpha	Homo sapiens	102-105
27403579-5	2016	Curcumin associated with phospholipid vesicles, phospholipid/NaC mixed vesicles, and phospholipid/NaC mixed micelles often results in higher intensities of absorption and fluorescence than those of free curcumin.	Curcumin	0-8	synuclein alpha	Homo sapiens	61-64
27403579-6	2016	However, phospholipid/NaC mixed vesicles lead to the highest values of absorption and fluorescence intensities, binding constant, and radical-scavenging capacity with curcumin.	Curcumin	167-175	synuclein alpha	Homo sapiens	22-25
27403579-7	2016	The different structures in the phospholipid bilayer of phospholipid/NaC mixed vesicles and the hydrophobic part of phospholipid/NaC mixed micelles where curcumin located are discussed to explain the interaction behaviors of phospholipid/NaC mixed systems with curcumin.	Curcumin	154-162	synuclein alpha	Homo sapiens	129-132
27860427-0	2016	The role of ADIPOQ methylation in curcumin-administrated experimental nonalcoholic fatty liver disease.	Curcumin	34-42	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	12-18
27403579-7	2016	The different structures in the phospholipid bilayer of phospholipid/NaC mixed vesicles and the hydrophobic part of phospholipid/NaC mixed micelles where curcumin located are discussed to explain the interaction behaviors of phospholipid/NaC mixed systems with curcumin.	Curcumin	154-162	synuclein alpha	Homo sapiens	129-132
27860427-7	2016	The ADIPOQ mRNA and protein expressions in the livers of the NAFLD rats was lower compared with the control and the curcumin-treated groups.	Curcumin	116-124	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	4-10
27446282-0	2016	HSP60 mediates the neuroprotective effects of curcumin by suppressing microglial activation.	Curcumin	46-54	heat shock protein 1 (chaperonin)	Mus musculus	0-5
27860427-8	2016	ADIPOQ methylation rate in the NAFLD group was significantly higher than in the control group, which was declined slightly following curcumin treatment.	Curcumin	133-141	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	0-6
27860427-10	2016	ALT, TC, TG and homeostatic model assessment insulin resistance index had a positive correlation with ADIPOQ DNA methylation, showing that curcumin might affect the gene expression involved in lipid and glucose metabolism by influencing ADIPOQ DNA methylation modifications, which contributed to alleviation of NAFLD.	Curcumin	139-147	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	102-108
27860427-10	2016	ALT, TC, TG and homeostatic model assessment insulin resistance index had a positive correlation with ADIPOQ DNA methylation, showing that curcumin might affect the gene expression involved in lipid and glucose metabolism by influencing ADIPOQ DNA methylation modifications, which contributed to alleviation of NAFLD.	Curcumin	139-147	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	237-243
27446282-4	2016	The results showed that curcumin significantly inhibited the LPS-induced expression and release of heat shock protein 60 (HSP60) in the BV2 cells.	Curcumin	24-32	heat shock protein 1 (chaperonin)	Mus musculus	99-120
27860427-11	2016	CONCLUSION: Altering the DNA methylation of ADIPOQ is one of the mechanisms by which curcumin executes its hepatoprotective function in NAFLD.	Curcumin	85-93	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	44-50
27446282-4	2016	The results showed that curcumin significantly inhibited the LPS-induced expression and release of heat shock protein 60 (HSP60) in the BV2 cells.	Curcumin	24-32	heat shock protein 1 (chaperonin)	Mus musculus	122-127
27916071-0	2016	[The effect of curcumin on the expression of miR-155 to apoptosis and invasion of extravillus trophoblast cells treated by lipopolysaccharide].	Curcumin	15-23	microRNA 155	Homo sapiens	45-52
27916071-1	2016	Objective: To investigate the effect of curcumin on the expression of miR-155, apoptosis and invasion of extravillus trophoblast cells treated by lipopolysaccharide (LPS).	Curcumin	40-48	microRNA 155	Homo sapiens	70-77
27446282-7	2016	Extracellular HSP60 is a ligand of Toll-like receptor 4 (TLR-4), and the level of the latter was increased in the LPS-activated BV2 microglia and inhibited by curcumin.	Curcumin	159-167	heat shock protein 1 (chaperonin)	Mus musculus	14-19
27446282-10	2016	These results indicate that curcumin may exert its neuroprotective and anti-inflammatory effects by inhibiting microglial activation through the HSP60/TLR-4/MyD88/NF-kappaB signaling wpathway.	Curcumin	28-36	heat shock protein 1 (chaperonin)	Mus musculus	145-150
32019426-7	2020	In the patch-clamp of SH-SY5Y cells and laser confocal microscopy experiments of optic nerve, CURCU and TRPM2 blocker treatments also decreased ADPR-induced TRPM2 currents and cytosolic free calcium ion (Ca2+) concentration, suggesting a suppression of Ca2+ influx and neuronal death.Conclusion: CURCU prevents CiSP-induced optic nerve oxidative injury and cell death by suppressing mitochondrial ROS production via regulating TRPM2 signaling pathways.	Curcumin	296-301	transient receptor potential cation channel subfamily M member 2	Homo sapiens	104-109
27982256-1	2016	PURPOSE:: To investigate the effect of curcumin on visfatin and zinc-alpha2-glycoprotein (ZAG) expression levels in rats with non-alcoholic fatty liver disease (NAFLD).	Curcumin	39-47	nicotinamide phosphoribosyltransferase	Rattus norvegicus	51-59
32213933-9	2020	Additionally, dietary curcumin enhanced protein (NQO1) and mRNA expression of genes (Nrf2, NQO1, gamma-glutamyltransferase 1 (GGT1), heme oxygenase-1 (HO-1), glutathione S-transferase (GST) and catalase (CAT)) as compared to the IUGR group (p < 0.05).	Curcumin	22-30	NAD(P)H quinone dehydrogenase 1	Sus scrofa	49-53
32213933-9	2020	Additionally, dietary curcumin enhanced protein (NQO1) and mRNA expression of genes (Nrf2, NQO1, gamma-glutamyltransferase 1 (GGT1), heme oxygenase-1 (HO-1), glutathione S-transferase (GST) and catalase (CAT)) as compared to the IUGR group (p < 0.05).	Curcumin	22-30	NAD(P)H quinone dehydrogenase 1	Sus scrofa	91-95
32213933-9	2020	Additionally, dietary curcumin enhanced protein (NQO1) and mRNA expression of genes (Nrf2, NQO1, gamma-glutamyltransferase 1 (GGT1), heme oxygenase-1 (HO-1), glutathione S-transferase (GST) and catalase (CAT)) as compared to the IUGR group (p < 0.05).	Curcumin	22-30	glutathione hydrolase 1 proenzyme	Sus scrofa	97-124
27982256-1	2016	PURPOSE:: To investigate the effect of curcumin on visfatin and zinc-alpha2-glycoprotein (ZAG) expression levels in rats with non-alcoholic fatty liver disease (NAFLD).	Curcumin	39-47	alpha-2-glycoprotein 1, zinc-binding	Rattus norvegicus	64-88
27982256-1	2016	PURPOSE:: To investigate the effect of curcumin on visfatin and zinc-alpha2-glycoprotein (ZAG) expression levels in rats with non-alcoholic fatty liver disease (NAFLD).	Curcumin	39-47	alpha-2-glycoprotein 1, zinc-binding	Rattus norvegicus	90-93
27982256-9	2016	Treatment of NAFLD in rats by curcumin may be mediated by the decrease of visfatin and the increase of non-alcoholic fatty liver disease.	Curcumin	30-38	nicotinamide phosphoribosyltransferase	Rattus norvegicus	74-82
26765996-0	2016	Up-regulated fractalkine (FKN) and its receptor CX3CR1 are involved in fructose-induced neuroinflammation: Suppression by curcumin.	Curcumin	122-130	chemokine (C-X3-C motif) receptor 1	Mus musculus	48-54
26134921-6	2016	Curcumin inhibited SHI-1 cell proliferation by arresting the cells in the S-phase, increasing the number of Annexin V-FITC(+)/PI(-) cells and promoting the loss of  Psim.	Curcumin	0-8	annexin A5	Homo sapiens	108-117
26765996-9	2016	Curcumin protected against neuronal damage in hippocampal DG of fructose-fed mice by inhibiting microglia activation and suppressed FKN/CX3CR1 up-regulation in the neuronal network.	Curcumin	0-8	chemokine (C-X3-C motif) receptor 1	Mus musculus	136-142
27514487-5	2016	Topical application of curcumin significantly inhibited acute UVB (540 mJ cm-2 , for 3 successive days)-induced inflammatory cells, collagen accrementition derangement and lipid peroxidation, and effectively induced NF-E2-related factor 2 (Nrf2) nuclear accumulation in uncovered (Uncv) hairless mice skin.	Curcumin	23-31	uncovered	Mus musculus	281-285
26134921-7	2016	The results of PCR and Western blotting showed that curcumin increased the FasL mRNA level; inhibited Bcl-2, NF-kappaB, and ERK expression; and activated P38 MAPK, JNK, and caspase-3.	Curcumin	52-60	Fas ligand	Homo sapiens	75-79
27629417-0	2016	Induction of Glucocorticoid-induced Leucine Zipper (GILZ) Contributes to Anti-inflammatory Effects of the Natural Product Curcumin in Macrophages.	Curcumin	122-130	TSC22 domain family, member 3	Mus musculus	13-50
32213933-9	2020	Additionally, dietary curcumin enhanced protein (NQO1) and mRNA expression of genes (Nrf2, NQO1, gamma-glutamyltransferase 1 (GGT1), heme oxygenase-1 (HO-1), glutathione S-transferase (GST) and catalase (CAT)) as compared to the IUGR group (p < 0.05).	Curcumin	22-30	glutathione hydrolase 1 proenzyme	Sus scrofa	126-130
32184643-11	2020	Besides, podocyte marker proteins (podocalyxin and nephrin) were markedly increased in DN mice by curcumin treatment.	Curcumin	98-106	podocalyxin-like	Mus musculus	35-46
27629417-0	2016	Induction of Glucocorticoid-induced Leucine Zipper (GILZ) Contributes to Anti-inflammatory Effects of the Natural Product Curcumin in Macrophages.	Curcumin	122-130	TSC22 domain family, member 3	Mus musculus	52-56
27306423-5	2016	We show that curcumin targets both stem cell populations by down-regulating expression of breast stem cell genes including ALDH1A3, CD49f, PROM1, and TP63.	Curcumin	13-21	aldehyde dehydrogenase 1 family member A3	Homo sapiens	123-130
27629417-11	2016	Our data employing siRNA in LPS-activated RAW264.7 macrophages show that curcumin facilitates its anti-inflammatory action by induction of GILZ in macrophages.	Curcumin	73-81	TSC22 domain family, member 3	Mus musculus	139-143
32184643-11	2020	Besides, podocyte marker proteins (podocalyxin and nephrin) were markedly increased in DN mice by curcumin treatment.	Curcumin	98-106	nephrosis 1, nephrin	Mus musculus	51-58
32184643-12	2020	The autophagy-related proteins LC3, p62, Beclin1, UVRAG and ATG5 were significantly affected in DN mice by curcumin, along with reducing expression of pro-apoptotic protein Bax and caspase-3 and increasing anti-apoptotic protein Bcl-2.	Curcumin	107-115	nucleoporin 62	Mus musculus	36-39
32184643-12	2020	The autophagy-related proteins LC3, p62, Beclin1, UVRAG and ATG5 were significantly affected in DN mice by curcumin, along with reducing expression of pro-apoptotic protein Bax and caspase-3 and increasing anti-apoptotic protein Bcl-2.	Curcumin	107-115	caspase 3	Mus musculus	181-190
27306423-5	2016	We show that curcumin targets both stem cell populations by down-regulating expression of breast stem cell genes including ALDH1A3, CD49f, PROM1, and TP63.	Curcumin	13-21	tumor protein p63	Homo sapiens	150-154
31972171-0	2020	Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.	Curcumin	0-8	kelch-like ECH-associated protein 1	Mus musculus	55-60
27278959-9	2016	Furthermore, curcumin increased the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), but AMPK inhibitor BML-275 significantly abolished the curcumin downregulation of HK, PFK2, and glut4.	Curcumin	167-175	solute carrier family 2 member 4	Rattus norvegicus	208-213
31972171-6	2020	Cells transfected with a mutant Keap1 protein in which cysteine 151 is replaced by serine exhibited marked reduction in curcumin-induced Nrf2 transactivation.	Curcumin	120-128	kelch-like ECH-associated protein 1	Mus musculus	32-37
31972171-7	2020	Mass spectrometric analysis revealed that curcumin binds to Keap1 Cys151, supporting that this amino acid is a critical target for curcumin modification of Keap1, which facilitates the liberation of Nrf2.	Curcumin	42-50	kelch-like ECH-associated protein 1	Mus musculus	60-65
27579532-4	2016	L-Ferritin internalization was exploited for the simultaneous delivery of Curcumin, a natural therapeutic molecule endowed with antineoplastic action, and the MRI contrast agent Gd-HPDO3A, both entrapped in the L-Ferritin cavity.	Curcumin	74-82	ferritin light polypeptide 1	Mus musculus	0-10
27579532-6	2016	In conclusion, here we show that Curcumin-loaded L-Ferritin has a strong therapeutic potential due to the specific targeting of CSC and the improved Curcumin bioavailability, opening up the possibility of its use in a clinical setting.	Curcumin	33-41	ferritin light polypeptide 1	Mus musculus	49-59
27579532-6	2016	In conclusion, here we show that Curcumin-loaded L-Ferritin has a strong therapeutic potential due to the specific targeting of CSC and the improved Curcumin bioavailability, opening up the possibility of its use in a clinical setting.	Curcumin	149-157	ferritin light polypeptide 1	Mus musculus	49-59
31972171-7	2020	Mass spectrometric analysis revealed that curcumin binds to Keap1 Cys151, supporting that this amino acid is a critical target for curcumin modification of Keap1, which facilitates the liberation of Nrf2.	Curcumin	42-50	kelch-like ECH-associated protein 1	Mus musculus	156-161
31972171-7	2020	Mass spectrometric analysis revealed that curcumin binds to Keap1 Cys151, supporting that this amino acid is a critical target for curcumin modification of Keap1, which facilitates the liberation of Nrf2.	Curcumin	131-139	kelch-like ECH-associated protein 1	Mus musculus	60-65
27278959-10	2016	In addition, curcumin inhibition of alpha-SMA and alpha1(I)procollagen was rescued by BML-275, and curcumin upregulation of C/EBPalpha and PPAR-gamma was abrogated by BML-275.	Curcumin	13-21	actin gamma 2, smooth muscle	Rattus norvegicus	36-45
31972171-7	2020	Mass spectrometric analysis revealed that curcumin binds to Keap1 Cys151, supporting that this amino acid is a critical target for curcumin modification of Keap1, which facilitates the liberation of Nrf2.	Curcumin	131-139	kelch-like ECH-associated protein 1	Mus musculus	156-161
31972171-8	2020	Thus, it is likely that the alpha,beta-unsaturated carbonyl moiety of curcumin is critical essential for its binding to Keap1 and stabilization of Nrf2 by hampering ubiquitination and proteasomal degradation.	Curcumin	70-78	kelch-like ECH-associated protein 1	Mus musculus	120-125
27777867-0	2016	Multivariate analysis and molecular interaction of curcumin with PPARgamma in high fructose diet induced insulin resistance in rats.	Curcumin	51-59	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	65-74
27777867-5	2016	Subsequently, molecular docking was carried out to determine the binding efficiency of curcumin as agonist of PPARgamma showed high affinity compared to pioglitazone.	Curcumin	87-95	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	110-119
27278959-10	2016	In addition, curcumin inhibition of alpha-SMA and alpha1(I)procollagen was rescued by BML-275, and curcumin upregulation of C/EBPalpha and PPAR-gamma was abrogated by BML-275.	Curcumin	99-107	CCAAT/enhancer binding protein alpha	Rattus norvegicus	124-134
27777867-7	2016	Overall, these results demonstrate the preventive role of curcumin on diet induced insulin resistant in rats by ameliorating the altered levels of metabolic changes and potential binding of curcumin with PPARgamma as agonist in the treatment of insulin resistance.	Curcumin	58-66	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	204-213
27777867-7	2016	Overall, these results demonstrate the preventive role of curcumin on diet induced insulin resistant in rats by ameliorating the altered levels of metabolic changes and potential binding of curcumin with PPARgamma as agonist in the treatment of insulin resistance.	Curcumin	190-198	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	204-213
32114280-3	2020	We hypothesized that curcumin could inhibit interferon (IFN)-gamma and interleukin (IL)-17 production in peripheral blood mononuclear cells from patients with psoriasis and psoriatic arthritis (PsA).	Curcumin	21-29	interleukin 17A	Homo sapiens	71-90
29336533-4	2016	The goal of this study was to validate the in vivo targeting potential and evaluate the combinatorial therapeutic potential of novel Annexin A2 (AnxA2) antibody-conjugated curcumin loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (AnxA2-CPNP) against metastatic breast cancer.	Curcumin	172-180	annexin A2	Homo sapiens	133-143
32114280-6	2020	Curcumin significantly decreased, in a dose dependent manner, IFNgamma-production by CD4(+) and CD8(+) T cells, and NK and NKT cells in patients with psoriatic disease and healthy controls.	Curcumin	0-8	CD8a molecule	Homo sapiens	96-99
32114280-9	2020	In conclusion, curcumin in vitro inhibits pro-inflammatory IFN-gamma and IL-17 production in psoriatic disease, and this may strengthen its role as a dietary immunosuppressant in patients with this disease.	Curcumin	15-23	interleukin 17A	Homo sapiens	73-78
31778793-7	2020	Curcumin pre-treatment both in vitro and in vivo showed significant changes in TJ protein integrity, attenuated NF-kappaB activity with reduced expression of its regulatory genes in lung tissues, serum and bronchoalveolar lavage fluid (BALF) along with stabilized HIF-1alpha levels under hypoxia.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	264-274
27451029-4	2016	We have recently enhanced solubility of curcumin via a novel dendrosomal nanoformulation (DNC).	Curcumin	40-48	solute carrier family 25 member 19	Homo sapiens	90-93
27451029-7	2016	Treatment by DNC, showing superiority to curcumin, effectively counteracted these effects and reduced DNA damage as determined via 8-OHdG levels and lipid peroxidation as measured by the level of TBARS (as well as lipid hydroperoxides and 8-isoprostane).	Curcumin	41-49	solute carrier family 25 member 19	Homo sapiens	13-16
29336533-4	2016	The goal of this study was to validate the in vivo targeting potential and evaluate the combinatorial therapeutic potential of novel Annexin A2 (AnxA2) antibody-conjugated curcumin loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (AnxA2-CPNP) against metastatic breast cancer.	Curcumin	172-180	annexin A2	Homo sapiens	145-150
27382986-0	2016	Impairment of autophagy by TTR V30M aggregates: in vivo reversal by TUDCA and curcumin.	Curcumin	78-86	transthyretin	Mus musculus	27-30
29336533-4	2016	The goal of this study was to validate the in vivo targeting potential and evaluate the combinatorial therapeutic potential of novel Annexin A2 (AnxA2) antibody-conjugated curcumin loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (AnxA2-CPNP) against metastatic breast cancer.	Curcumin	172-180	annexin A2	Homo sapiens	240-245
27382986-5	2016	Our studies performed in TTR V30M transgenic animals demonstrated that tauroursodeoxycholic acid (TUDCA) and curcumin effectively reverse p62 accumulation in the GI tract pointing to the ability of both compounds to modulate autophagy additionally to mitigate apoptosis.	Curcumin	109-117	transthyretin	Mus musculus	25-28
29336533-6	2016	This confirmed AnxA2 as an excellent target for targeting our curcumin nanoparticles.	Curcumin	62-70	annexin A2	Homo sapiens	15-20
27382986-5	2016	Our studies performed in TTR V30M transgenic animals demonstrated that tauroursodeoxycholic acid (TUDCA) and curcumin effectively reverse p62 accumulation in the GI tract pointing to the ability of both compounds to modulate autophagy additionally to mitigate apoptosis.	Curcumin	109-117	nucleoporin 62	Mus musculus	138-141
27482284-7	2016	All of the studies indicated that curcumin decreased glioblastoma cell viability through various pathways (i.e. decrease in prosurvival proteins such as nuclear factor kappaB, activator protein 1, and phosphoinositide 3 kinase, and upregulation of apoptotic pathways like p21, p53, and executor caspase 3).	Curcumin	34-42	H3 histone pseudogene 16	Homo sapiens	272-275
27146402-0	2016	Curcumin Exerts its Anti-hypertensive Effect by Down-regulating the AT1 Receptor in Vascular Smooth Muscle Cells.	Curcumin	0-8	angiotensin II, type I receptor-associated protein	Mus musculus	68-80
27544348-15	2016	CONCLUSION: The anti-inflammatory effect of curcumin is realized by enhancing SOCS-1 expression and inhibiting JAK/STAT pathways.	Curcumin	44-52	suppressor of cytokine signaling 1	Rattus norvegicus	78-84
27594837-0	2016	Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer"s Disease.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	77-125
27594837-2	2016	Curcumin is not only a potent PPARgamma agonist, but also has neuroprotective effects on cerebral ischemic injury.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	30-39
27146402-3	2016	We propose that curcumin prevents the development of hypertension by regulating AT1 receptor (AT1R) expression in arteries.	Curcumin	16-24	angiotensin II, type I receptor-associated protein	Mus musculus	80-92
27203664-7	2016	Furthermore, curcumin increased cluster of differentiation (CD)163 expression, and down-regulated renal expression of antigen II type I receptor (AT1R), endothelin (ET)1, ET receptor type A and B (ETAR and ETBR), CD68 and CD80.	Curcumin	13-21	Cd80 molecule	Rattus norvegicus	222-226
27146402-3	2016	We propose that curcumin prevents the development of hypertension by regulating AT1 receptor (AT1R) expression in arteries.	Curcumin	16-24	angiotensin II, type I receptor-associated protein	Mus musculus	94-98
27234697-9	2016	Annexin-V-PI test showed curcumin-induced apoptosis was enhanced in Huh7 as well as HepG2, compared to untreated cells.	Curcumin	25-33	MIR7-3 host gene	Homo sapiens	68-72
27283735-0	2016	Curcumin inhibits HIV-1 by promoting Tat protein degradation.	Curcumin	0-8	Tat	Human immunodeficiency virus 1	37-40
27258084-8	2016	In the present study, we performed in silico studies to quantitatively scrutinize the molecular interaction of curcumin and its structural analogs with COX-2, COX-1, FXa and integrin alphaIIbbetaIII to investigate their therapeutic potential as a cardiovascular-safe anti-inflammatory medicine (CVSAIM).	Curcumin	111-119	coagulation factor X	Homo sapiens	166-169
27146402-4	2016	The present study examined how curcumin regulates AT1R expression in vascular smooth muscle cells and investigated the physiological significance of this regulation in angiotensin (Ang) II-induced hypertension.	Curcumin	31-39	angiotensin II, type I receptor-associated protein	Mus musculus	50-54
27448781-0	2016	Curcumin protects against liver fibrosis by attenuating infiltration of Gr1hi monocytes through inhibition of monocyte chemoattractant protein-1.	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	110-144
27448781-2	2016	We aimed to investigate whether curcumin might protect the liver from carbon tetrachloride (CCl4)-induced fibrosis by attenuating the recruitment of Gr1hi monocytes through inhibition of monocyte chemoattractant protein-1 (MCP-1).	Curcumin	32-40	chemokine (C-C motif) ligand 4	Mus musculus	92-96
27146402-5	2016	The results showed that curcumin decreased AT1R expression in a concentration- and time-dependent manner in vascular smooth muscle cells.	Curcumin	24-32	angiotensin II, type I receptor-associated protein	Mus musculus	43-47
27448781-2	2016	We aimed to investigate whether curcumin might protect the liver from carbon tetrachloride (CCl4)-induced fibrosis by attenuating the recruitment of Gr1hi monocytes through inhibition of monocyte chemoattractant protein-1 (MCP-1).	Curcumin	32-40	chemokine (C-C motif) ligand 2	Mus musculus	187-221
27448781-2	2016	We aimed to investigate whether curcumin might protect the liver from carbon tetrachloride (CCl4)-induced fibrosis by attenuating the recruitment of Gr1hi monocytes through inhibition of monocyte chemoattractant protein-1 (MCP-1).	Curcumin	32-40	chemokine (C-C motif) ligand 2	Mus musculus	223-228
27146402-6	2016	Using luciferase reporters with an entire AT1 or a mutant AT1R in A10 cells, the AT1R promoter activity was inhibited by 10(-6 )M curcumin, and the proximal element (from -61 to +25 bp) of the AT1R promoter was crucial for curcumin-induced AT1R down-regulation.	Curcumin	130-138	angiotensin II, type I receptor-associated protein	Mus musculus	58-62
27448781-13	2016	Intrahepatic MCP-1 expression of CCl4-challenged mice was inhibited by curcumin.	Curcumin	71-79	chemokine (C-C motif) ligand 2	Mus musculus	13-18
27146402-6	2016	Using luciferase reporters with an entire AT1 or a mutant AT1R in A10 cells, the AT1R promoter activity was inhibited by 10(-6 )M curcumin, and the proximal element (from -61 to +25 bp) of the AT1R promoter was crucial for curcumin-induced AT1R down-regulation.	Curcumin	130-138	angiotensin II, type I receptor-associated protein	Mus musculus	81-85
27448781-13	2016	Intrahepatic MCP-1 expression of CCl4-challenged mice was inhibited by curcumin.	Curcumin	71-79	chemokine (C-C motif) ligand 4	Mus musculus	33-37
27448781-14	2016	CONCLUSIONS: The anti-inflammatory and antifibrotic effects of curcumin could be contributed to its prevention of Gr1hi monocyte infiltration into the injured livers through inhibition of MCP-1.	Curcumin	63-71	chemokine (C-C motif) ligand 2	Mus musculus	188-193
27146402-6	2016	Using luciferase reporters with an entire AT1 or a mutant AT1R in A10 cells, the AT1R promoter activity was inhibited by 10(-6 )M curcumin, and the proximal element (from -61 to +25 bp) of the AT1R promoter was crucial for curcumin-induced AT1R down-regulation.	Curcumin	130-138	angiotensin II, type I receptor-associated protein	Mus musculus	81-85
27146402-6	2016	Using luciferase reporters with an entire AT1 or a mutant AT1R in A10 cells, the AT1R promoter activity was inhibited by 10(-6 )M curcumin, and the proximal element (from -61 to +25 bp) of the AT1R promoter was crucial for curcumin-induced AT1R down-regulation.	Curcumin	130-138	angiotensin II, type I receptor-associated protein	Mus musculus	81-85
27146402-6	2016	Using luciferase reporters with an entire AT1 or a mutant AT1R in A10 cells, the AT1R promoter activity was inhibited by 10(-6 )M curcumin, and the proximal element (from -61 to +25 bp) of the AT1R promoter was crucial for curcumin-induced AT1R down-regulation.	Curcumin	223-231	angiotensin II, type I receptor-associated protein	Mus musculus	81-85
26957323-6	2016	Immunohistochemistry and western blot analyses revealed that the expressions of PSD95 and Shank1 were reduced in the hippocampal CA1 areas of the APPswe/PS1dE9 double transgenic mice, but curcumin treatment increased the expressions of these proteins.	Curcumin	188-196	discs large MAGUK scaffold protein 4	Mus musculus	80-85
27146402-6	2016	Using luciferase reporters with an entire AT1 or a mutant AT1R in A10 cells, the AT1R promoter activity was inhibited by 10(-6 )M curcumin, and the proximal element (from -61 to +25 bp) of the AT1R promoter was crucial for curcumin-induced AT1R down-regulation.	Curcumin	223-231	angiotensin II, type I receptor-associated protein	Mus musculus	81-85
26957323-7	2016	Our findings suggest that curcumin improved the structure and function of the synapses by regulating the synapse-related proteins PSD95 and Shank1.	Curcumin	26-34	discs large MAGUK scaffold protein 4	Mus musculus	130-135
26957323-7	2016	Our findings suggest that curcumin improved the structure and function of the synapses by regulating the synapse-related proteins PSD95 and Shank1.	Curcumin	26-34	SH3 and multiple ankyrin repeat domains 1	Mus musculus	140-146
27146402-6	2016	Using luciferase reporters with an entire AT1 or a mutant AT1R in A10 cells, the AT1R promoter activity was inhibited by 10(-6 )M curcumin, and the proximal element (from -61 to +25 bp) of the AT1R promoter was crucial for curcumin-induced AT1R down-regulation.	Curcumin	223-231	angiotensin II, type I receptor-associated protein	Mus musculus	81-85
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	cadherin 2	Homo sapiens	142-152
27146402-8	2016	Curcumin treatment reduced Ang II-induced hypertension in C57Bl/6J mice, which was accompanied by lower AT1R expression in the arteries and decreased Ang II-mediated vasoconstriction in the mesenteric artery.	Curcumin	0-8	angiotensin II, type I receptor-associated protein	Mus musculus	104-108
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	snail family transcriptional repressor 2	Homo sapiens	168-172
27146402-9	2016	These findings indicate that curcumin down-regulates AT1R expression in A10 cells by affecting SP1/AT1R DNA binding, thus reducing AT1R-mediated vasoconstriction and subsequently prevents the development of hypertension in an Ang II-induced hypertensive model.	Curcumin	29-37	angiotensin II, type I receptor-associated protein	Mus musculus	53-57
26872103-0	2016	Curcumin Ameliorates Reserpine-Induced Gastrointestinal Mucosal Lesions Through Inhibiting IkappaB-alpha/NF-kappaB Pathway and Regulating Expression of Vasoactive Intestinal Peptide and Gastrin in Rats.	Curcumin	0-8	gastrin	Rattus norvegicus	186-193
26872103-8	2016	Curcumin treatment prevented tissue damage and cell death in the reserpine-treated rats and effectively decreased inflammatory response and balanced the expression of VIP and gastrin in the reserpine-treated rats.	Curcumin	0-8	gastrin	Rattus norvegicus	175-182
26872103-10	2016	Curcumin can target the IkappaB-alpha/NF-kappaB pathway to inhibit inflammatory response and regulate the level of VIP and gastrin in reserpine-induced GML rats.	Curcumin	0-8	gastrin	Rattus norvegicus	123-130
27026405-0	2016	Curcumin downregulates p38 MAPK-dependent X-ray repair cross-complement group 1 (XRCC1) expression to enhance cisplatin-induced cytotoxicity in human lung cancer cells.	Curcumin	0-8	X-ray repair cross complementing 1	Homo sapiens	42-79
27146402-9	2016	These findings indicate that curcumin down-regulates AT1R expression in A10 cells by affecting SP1/AT1R DNA binding, thus reducing AT1R-mediated vasoconstriction and subsequently prevents the development of hypertension in an Ang II-induced hypertensive model.	Curcumin	29-37	angiotensin II, type I receptor-associated protein	Mus musculus	99-103
27026405-0	2016	Curcumin downregulates p38 MAPK-dependent X-ray repair cross-complement group 1 (XRCC1) expression to enhance cisplatin-induced cytotoxicity in human lung cancer cells.	Curcumin	0-8	X-ray repair cross complementing 1	Homo sapiens	81-86
27026405-4	2016	In this study, we characterize the role of curcumin in the cytotoxicity, p38 MAPK activation, and XRCC1 expression affected by cisplatin in NSCLC cells.	Curcumin	43-51	X-ray repair cross complementing 1	Homo sapiens	98-103
27146402-9	2016	These findings indicate that curcumin down-regulates AT1R expression in A10 cells by affecting SP1/AT1R DNA binding, thus reducing AT1R-mediated vasoconstriction and subsequently prevents the development of hypertension in an Ang II-induced hypertensive model.	Curcumin	29-37	angiotensin II, type I receptor-associated protein	Mus musculus	99-103
26108947-5	2016	The compounds were ranked based on Glide extra precision docking score and five hits (curcumin, quercetin, morin, naringin and silibinin) were selected on the basis of their interaction with active site amino acid residues of GLO-I.	Curcumin	86-94	glyoxalase I	Homo sapiens	226-231
27197872-0	2016	Curcumin: A multi-target disease-modifying agent for late-stage transthyretin amyloidosis.	Curcumin	0-8	transthyretin	Mus musculus	64-77
27197872-3	2016	In this study, we evaluate the protective effect of physiologically achievable doses of curcumin on the cytotoxicity induced by transthyretin oligomers in vitro by showing reduction of caspase-3 activity and the levels of endoplasmic reticulum-resident chaperone binding immunoglobulin protein.	Curcumin	88-96	transthyretin	Mus musculus	128-141
27077805-0	2016	Activation of PPARgamma/P53 signaling is required for curcumin to induce hepatic stellate cell senescence.	Curcumin	54-62	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	24-27
27197872-3	2016	In this study, we evaluate the protective effect of physiologically achievable doses of curcumin on the cytotoxicity induced by transthyretin oligomers in vitro by showing reduction of caspase-3 activity and the levels of endoplasmic reticulum-resident chaperone binding immunoglobulin protein.	Curcumin	88-96	caspase 3	Mus musculus	185-194
27197872-4	2016	When given to an aged Familial Amyloidotic Polyneuropathy mouse model, curcumin not only reduced transthyretin aggregates deposition and toxicity in both gastrointestinal tract and dorsal root ganglia but also remodeled congophilic amyloid material in tissues.	Curcumin	71-79	transthyretin	Mus musculus	97-110
27197872-5	2016	In addition, curcumin enhanced internalization, intracellular transport and degradation of transthyretin oligomers by primary macrophages from aged Familial Amyloidotic Polyneuropathy transgenic mice, suggesting an impaired activation of naive phagocytic cells exposed to transthyretin toxic intermediate species.	Curcumin	13-21	transthyretin	Mus musculus	91-104
27197872-5	2016	In addition, curcumin enhanced internalization, intracellular transport and degradation of transthyretin oligomers by primary macrophages from aged Familial Amyloidotic Polyneuropathy transgenic mice, suggesting an impaired activation of naive phagocytic cells exposed to transthyretin toxic intermediate species.	Curcumin	13-21	transthyretin	Mus musculus	272-285
27197872-6	2016	Overall, our results clearly support curcumin or optimized derivatives as promising multi-target disease-modifying agent for late-stage transthyretin amyloidosis.	Curcumin	37-45	transthyretin	Mus musculus	136-149
27026486-8	2016	Moreover, Western blot analysis and immunostaining indicated that treatment with curcumin significantly reduced the expression of a vascular cell adhesion molecule-1 (VCAM-1), interferon-gamma (INF-gamma) and interleukin-17 (IL-17) in the mouse brain at 72h post-ICH.	Curcumin	81-89	interleukin 17A	Mus musculus	209-223
27026486-8	2016	Moreover, Western blot analysis and immunostaining indicated that treatment with curcumin significantly reduced the expression of a vascular cell adhesion molecule-1 (VCAM-1), interferon-gamma (INF-gamma) and interleukin-17 (IL-17) in the mouse brain at 72h post-ICH.	Curcumin	81-89	interleukin 17A	Mus musculus	225-230
27077805-12	2016	Moreover, promoting PPARgamma transactivating activity by a PPARgamma agonist 15d-PGJ2 markedly enhanced curcumin induction of senescence of activated HSCs.	Curcumin	105-113	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	20-29
27077805-5	2016	In this study, curcumin promoted the expression of senescence marker Hmga1 in rat fibrotic liver.	Curcumin	15-23	high mobility group AT-hook 1	Rattus norvegicus	69-74
27077805-12	2016	Moreover, promoting PPARgamma transactivating activity by a PPARgamma agonist 15d-PGJ2 markedly enhanced curcumin induction of senescence of activated HSCs.	Curcumin	105-113	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	60-69
27077805-13	2016	However, the PPARgamma antagonist PD68235 eliminated curcumin induction of HSC senescence.	Curcumin	53-61	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	13-22
27077805-6	2016	In addition, curcumin increased the number of senescence-associated beta-galactosidase-positive HSCs in vitro.	Curcumin	13-21	galactosidase, beta 1	Rattus norvegicus	68-86
27077805-7	2016	At the same time, curcumin induced HSC senescence by elevating the expression of senescence markers P16, P21 and Hmga1, concomitant with reduced abundance of HSC activation markers alpha-smooth muscle actin and alpha1(I)-procollagen in cultured HSCs.	Curcumin	18-26	high mobility group AT-hook 1	Rattus norvegicus	113-118
27077805-9	2016	We further demonstrated that P53 pharmacological inhibitor pifithrin-alpha (PFT-alpha) or transfection with P53 siRNA abrogated the curcumin-induced HSC senescence in vitro.	Curcumin	132-140	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	29-32
27077805-9	2016	We further demonstrated that P53 pharmacological inhibitor pifithrin-alpha (PFT-alpha) or transfection with P53 siRNA abrogated the curcumin-induced HSC senescence in vitro.	Curcumin	132-140	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	108-111
26906122-0	2016	Curcumin Induces Apoptosis of Colorectal Cancer Stem Cells by Coupling with CD44 Marker.	Curcumin	0-8	CD44 molecule (Indian blood group)	Homo sapiens	76-80
27077805-10	2016	Meanwhile, curcumin disruption of P53 leading to increased senescence of activated HSCs was further verified in vivo.	Curcumin	11-19	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	34-37
26502886-0	2016	Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP.	Curcumin	0-8	ATP binding cassette subfamily C member 2	Homo sapiens	92-96
26502886-8	2016	In the presence of 50 nM curcumin, the clearance of resveratrol-3-O-glucuronide and resveratrol-3-O-sulfate reduced in both MRP2-overexpressing MDCKII-UGT1A1 cells and Human UGT1A9-overexpressing HeLa cells.	Curcumin	25-33	ATP binding cassette subfamily C member 2	Homo sapiens	124-128
26502886-8	2016	In the presence of 50 nM curcumin, the clearance of resveratrol-3-O-glucuronide and resveratrol-3-O-sulfate reduced in both MRP2-overexpressing MDCKII-UGT1A1 cells and Human UGT1A9-overexpressing HeLa cells.	Curcumin	25-33	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	151-157
26502886-9	2016	CONCLUSIONS: These results suggest that curcumin alters the phase II distribution of resveratrol through inhibiting efflux transporters including MRP2 and BCRP.	Curcumin	40-48	ATP binding cassette subfamily C member 2	Homo sapiens	146-150
27077805-11	2016	Further studies indicated that curcumin promoted the expression of P53 through a PPARgamma activation-dependent mechanism.	Curcumin	31-39	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	67-70
26850372-0	2016	Inhibition of NF-kappaB translocation by curcumin analogs induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer.	Curcumin	41-49	thymidylate synthetase	Homo sapiens	97-117
26761722-0	2016	Intranasal curcumin ameliorates airway inflammation and obstruction by regulating MAPKinase activation (p38, Erk and JNK) and prostaglandin D2 release in murine model of asthma.	Curcumin	11-19	mitogen-activated protein kinase 8	Mus musculus	117-120
26761722-5	2016	These investigations suggest that intranasal curcumin (2.5 and 5.0 mg/kg) regulates airway inflammation and airway obstruction mainly by modulating cytokine levels (IL-4, 5, IFN-y and TNF-alpha) and sPLA2 activity thereby inhibiting PGD2 release and COX-2 expression.	Curcumin	45-53	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	199-204
26850372-5	2016	We tested the hypothesis that inhibition of NF-kappaB translocation by curcumin and its analogs EF31 and UBS109 can inhibit cell cycle progression and downregulate TS levels in colorectal cancer (CRC) cell lines.	Curcumin	71-79	thymidylate synthetase	Homo sapiens	164-166
26335543-9	2016	Systemic administration of curcumin significantly decreased the production of TNF-alpha, MIP-2, and IL-6 as well as neutrophil accumulation in bronchoalveolar lavage fluid, and also decreased pulmonary myeloperoxidase levels and the wet/dry weight ratio in mice subjected to LPS treatment.	Curcumin	27-35	myeloperoxidase	Mus musculus	202-217
27190933-11	2016	Subtoxic concentrations of the curcumin-TRAIL combination induced strong apoptotic response in KCL-22 cells as demonstrated by the binding of Annexin V-FITC.	Curcumin	31-39	annexin A5	Homo sapiens	142-151
27222610-5	2016	Moreover, LPO, PCC, and GST activity were reduced and the GSH level was increased upon the administration of curcumin along with NDEA.	Curcumin	109-117	hematopoietic prostaglandin D synthase	Rattus norvegicus	24-27
26691217-12	2016	Curcumin significantly increased the effectiveness of GEM treatment in vitro via the CUGBP2-mediated post-transcriptional regulation pathway.	Curcumin	0-8	CUGBP Elav-like family member 2	Homo sapiens	85-91
26863117-5	2016	Our hypothesis is that functional differences of SP-B variants and treatment with curcumin (CMC2.24) modulate lung injury in bacterial pneumonia.	Curcumin	82-90	surfactant associated protein B	Mus musculus	49-53
27073364-0	2016	New insight into curcumin-based therapy in spinal cord injuries: CISD2 regulation.	Curcumin	17-25	CDGSH iron sulfur domain 2	Homo sapiens	65-70
27595397-10	2016	RESULTS: Curcumin and KN93 significantly inhibited the activation of CaMKII/NF-kappaB signaling induced by diabetes or elevated glucose, and subsequently decreased the expression of VEGF, iNOS and ICAM-1.	Curcumin	9-17	intercellular adhesion molecule 1	Rattus norvegicus	197-203
26974552-0	2016	Correction: Curcumin Significantly Enhances Dual PI3K/Akt and mTOR Inhibitor NVP-BEZ235-Induced Apoptosis in Human Renal Carcinoma Caki Cells through Down-Regulation of p53-Dependent Bcl-2 Expression and Inhibition of Mcl-1 Protein Stability.	Curcumin	12-20	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	218-223
26767865-4	2016	MCP-1 levels in HK-2 cell-conditioned media were measured after pre-treatment with the transcription factor inhibitors curcumin or pyrrolidine dithiocarbamate.	Curcumin	119-127	chemokine (C-C motif) ligand 2	Mus musculus	0-5
26612707-5	2016	Moreover, Curcumin/CMC-peptide treatment during hypertrophy significantly improved cardiac function by downregulating expression of hypertrophy marker genes (ANF, beta-MHC), apoptotic mediators (Bax, Cytochrome-c) and activity of apoptotic markers (Caspase 3 and PARP); whereas free Curcumin in much higher dose showed minimal improvement during compromised cardiac function.	Curcumin	10-18	natriuretic peptide A	Rattus norvegicus	158-161
32166124-2	2020	On the other hand, regular physical activity and curcumin consumption as non-invasive interventions can have liver protective effects through enhancing antioxidant defense, and improving PON-1 and NF-kbeta (nuclear factor kappa B) gene expression.	Curcumin	49-57	paraoxonase 1	Rattus norvegicus	187-192
26943907-0	2016	The Curcumin Analog C-150, Influencing NF-kappaB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo.	Curcumin	4-12	Akt1	Drosophila melanogaster	58-61
32166124-7	2020	Results: The interaction of SWT and curcumin caused an increase in PON-1 gene expression (p = 0.02).	Curcumin	36-44	paraoxonase 1	Rattus norvegicus	67-72
31896509-0	2020	AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis.	Curcumin	33-41	androgen receptor	Mus musculus	0-2
26630272-7	2015	In animal experiment, SCID mice with PC-3 xenograft tumors were treated with alpha-tomatine and curcumin.	Curcumin	96-104	proprotein convertase subtilisin/kexin type 1	Mus musculus	37-41
26997983-0	2016	Curcumin alleviates brain edema by lowering AQP4 expression levels in a rat model of hypoxia-hypercapnia-induced brain damage.	Curcumin	0-8	aquaporin 4	Rattus norvegicus	44-48
26698266-11	2015	PON1 levels were increased with ischemia-reperfusion (p = 0.21) and decreased with curcumin treatment (p = 0.53), however these changes were not statistically significant.	Curcumin	83-91	paraoxonase 1	Rattus norvegicus	0-4
31896509-6	2020	Herein, we observed that ALZ003, a curcumin analog, induces FBXL2-mediated AR ubiquitination, leading to degradation.	Curcumin	35-43	androgen receptor	Mus musculus	75-77
31963896-0	2020	Curcumin Affects HSP60 Folding Activity and Levels in Neuroblastoma Cells.	Curcumin	0-8	heat shock protein family D (Hsp60) member 1	Homo sapiens	17-22
31963896-5	2020	High HSP60 levels were correlated, in particular, with cancer development and progression, and for this reason, we investigated the ability of curcumin to affect HSP60 expression, localization, and post-translational modifications using a neuroblastoma cell line.	Curcumin	143-151	heat shock protein family D (Hsp60) member 1	Homo sapiens	162-167
31963896-6	2020	We have also looked at the ability of curcumin to interfere with the HSP60/HSP10 folding machinery.	Curcumin	38-46	heat shock protein family D (Hsp60) member 1	Homo sapiens	69-74
31963896-8	2020	This dose of curcumin-induced a decrease in HSP60 protein levels and an upregulation of HSP60 mRNA expression.	Curcumin	13-21	heat shock protein family D (Hsp60) member 1	Homo sapiens	44-49
31963896-8	2020	This dose of curcumin-induced a decrease in HSP60 protein levels and an upregulation of HSP60 mRNA expression.	Curcumin	13-21	heat shock protein family D (Hsp60) member 1	Homo sapiens	88-93
26997983-7	2016	Conversely, the rats treated with CU or GM1 exhibited attenuated HHBD-induced brain edema and tissue structure disruption, and decreased mRNA and protein expression levels of AQP4.	Curcumin	34-36	aquaporin 4	Rattus norvegicus	175-179
31963896-9	2020	Moreover, 25 microM of curcumin reduced HSP60 ubiquitination and nitration, and the chaperonin levels were higher in the culture media compared with the untreated cells.	Curcumin	23-31	heat shock protein family D (Hsp60) member 1	Homo sapiens	40-45
31963896-10	2020	Furthermore, curcumin at the same dose was able to favor HSP60 folding activity.	Curcumin	13-21	heat shock protein family D (Hsp60) member 1	Homo sapiens	57-62
31963896-11	2020	The reduction of HSP60 levels, together with the increase in its folding activity and the secretion in the media led to the supposition that curcumin might interfere with cancer progression with a protective mechanism involving the chaperonin.	Curcumin	141-149	heat shock protein family D (Hsp60) member 1	Homo sapiens	17-22
26387034-0	2015	CISD2 serves a novel role as a suppressor of nitric oxide signalling and curcumin increases CISD2 expression in spinal cord injuries.	Curcumin	73-81	CDGSH iron sulfur domain 2	Homo sapiens	92-97
26387034-4	2015	The authors previously demonstrated the neuroprotective effects of curcumin against RANTES-mediated neuroinflammation.	Curcumin	67-75	C-C motif chemokine ligand 5	Homo sapiens	84-90
26997983-8	2016	The results of the present study suggested that CU treatment was able to attenuate HHBD-induced brain edema by downregulating the expression levels of AQP4 in a rat model.	Curcumin	48-50	aquaporin 4	Rattus norvegicus	151-155
26387034-10	2015	RESULTS: The injuries were shown to reduce CISD2 mRNA and protein expression in vivo, and CISD2-positive cells were upregulated by the curcumin treatment.	Curcumin	135-143	CDGSH iron sulfur domain 2	Homo sapiens	90-95
26387034-11	2015	LPS led to a decrease in CISD2 expression in vitro; however, treatment with 1 muM curcumin attenuated the downregulation of CISD2.	Curcumin	82-90	CDGSH iron sulfur domain 2	Homo sapiens	25-30
26998027-0	2016	Curcumin suppresses transforming growth factor-beta1-induced cardiac fibroblast differentiation via inhibition of Smad-2 and p38 MAPK signaling pathways.	Curcumin	0-8	SMAD family member 2	Rattus norvegicus	114-120
26387034-11	2015	LPS led to a decrease in CISD2 expression in vitro; however, treatment with 1 muM curcumin attenuated the downregulation of CISD2.	Curcumin	82-90	CDGSH iron sulfur domain 2	Homo sapiens	124-129
26387034-13	2015	CONCLUSIONS: To the best of our knowledge, this is the first study to report the following: (1) CISD2 exerts anti-apoptotic and anti-inflammatory effects in neural cells; and (2) curcumin can attenuate the downregulation of CISD2 in SCI and LPS-treated astrocytes.	Curcumin	179-187	CDGSH iron sulfur domain 2	Homo sapiens	96-101
26998027-7	2016	The results demonstrated that the TGF-beta1-induced expression of alpha-SMA and ColI was suppressed by curcumin at the mRNA and protein levels, while SB431542 and SB203580 induced similar effects.	Curcumin	103-111	actin gamma 2, smooth muscle	Rattus norvegicus	72-75
26387034-13	2015	CONCLUSIONS: To the best of our knowledge, this is the first study to report the following: (1) CISD2 exerts anti-apoptotic and anti-inflammatory effects in neural cells; and (2) curcumin can attenuate the downregulation of CISD2 in SCI and LPS-treated astrocytes.	Curcumin	179-187	CDGSH iron sulfur domain 2	Homo sapiens	224-229
26998027-8	2016	Furthermore, phosphorylated Smad-2 and p38 were upregulated in TGF-beta1-induced CFs, and these effects were substantially inhibited by curcumin administration.	Curcumin	136-144	SMAD family member 2	Rattus norvegicus	28-34
26456836-11	2015	Curcumin also inhibited superoxide anion-induced leukocyte recruitment in the peritoneal cavity and in the paw skin inhibited myeloperoxidase activity, oxidative stress, IL-1beta and TNF-alpha production and NF-kappaB activation as well as enhanced IL-10 production, and HO-1 and Nrf2 mRNA expression.	Curcumin	0-8	interleukin 10	Homo sapiens	249-254
26998027-9	2016	In conclusion, the results of the present study demonstrated that treatment with curcumin effectively suppresses TGF-beta1-induced CF differentiation via Smad-2 and p38 signaling pathways.	Curcumin	81-89	SMAD family member 2	Rattus norvegicus	154-160
26499200-6	2015	However, curcumin abrogated CAF-induced invasion and EMT, and inhibited ROS production and CXCR4 and IL-6 receptor expression in prostate cancer cells through inhibiting MAOA/mTOR/HIF-1alpha signaling, thereby supporting the therapeutic effect of curcumin in prostate cancer.	Curcumin	9-17	C-X-C motif chemokine receptor 4	Homo sapiens	91-96
31678610-5	2020	Curcumin could also abate RANKL"s stimulatory effect on OCP autophagy and osteoclastogenesis.	Curcumin	0-8	TNF superfamily member 11	Homo sapiens	26-31
26985469-0	2016	Retraction notice to "Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines" [Biochem.	Curcumin	22-30	H3 histone pseudogene 16	Homo sapiens	166-169
32021440-0	2020	Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a.	Curcumin	10-18	forkhead box O3	Mus musculus	123-129
26375757-5	2015	Curcumin inhibited expressions of VEGF receptors (VEGFR2 and VEGFR3), as well as downstream signaling such as phosphorylation of ERK and FAK.	Curcumin	0-8	kinase insert domain receptor	Homo sapiens	50-56
26375757-5	2015	Curcumin inhibited expressions of VEGF receptors (VEGFR2 and VEGFR3), as well as downstream signaling such as phosphorylation of ERK and FAK.	Curcumin	0-8	fms related receptor tyrosine kinase 4	Homo sapiens	61-67
26985469-0	2016	Retraction notice to "Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines" [Biochem.	Curcumin	22-30	interferon alpha inducible protein 27	Homo sapiens	174-177
26515751-8	2016	In cultured primary osteoblasts, pretreatment with curcumin concentration-dependently decreased the number of Dex-induced apoptotic osteoblasts by down-regulating the ratio of Bax/Bcl-2 as well as the levels of cleaved caspase-3 and cleaved poly ADP-ribose polymerase (PARP).	Curcumin	51-59	BCL2 associated X, apoptosis regulator	Rattus norvegicus	176-179
26407474-10	2015	SIGNIFICANCE: The major finding of the study is that curcumin restored the core and associated symptoms of autistic phenotype by suppressing oxidative-nitrosative stress, mitochondrial dysfunction, TNF-alpha and MMP-9 in PPA-induced autism in rats.	Curcumin	53-61	matrix metallopeptidase 9	Rattus norvegicus	212-217
32096742-9	2020	Furthermore, curcumin enhanced the co-localization of LC3B and mitochondrial marker VDAC1, the ratio of LC3-II to LC3-I, improving cerebral I/R-induced mitophagy.	Curcumin	13-21	voltage-dependent anion channel 1	Rattus norvegicus	84-89
31441735-0	2020	Curcumin Suppresses Epithelial Growth Factor Receptor (EGFR) and Proliferative Protein (Ki 67) in Acute Lung Injury and Lung Fibrosis In Vitro and In Vivo.	Curcumin	0-8	antigen identified by monoclonal antibody Ki 67	Mus musculus	88-93
26515751-8	2016	In cultured primary osteoblasts, pretreatment with curcumin concentration-dependently decreased the number of Dex-induced apoptotic osteoblasts by down-regulating the ratio of Bax/Bcl-2 as well as the levels of cleaved caspase-3 and cleaved poly ADP-ribose polymerase (PARP).	Curcumin	51-59	poly (ADP-ribose) polymerase 1	Rattus norvegicus	241-267
31441735-3	2020	OBJECTIVE: The aim of the study was to evaluate effect of curcumin as an intervention on two prognostic markers EGFR and Ki67 in bleomycin induced basal alveolar epithelial cells and C57BL/6 mice.	Curcumin	58-66	antigen identified by monoclonal antibody Ki 67	Mus musculus	121-125
31441735-8	2020	KEY FINDINGS: The natural polyphenol curcumin could downregulate the expressions levels of Ki67 and EGFR both in vitro and in vivo.	Curcumin	37-45	antigen identified by monoclonal antibody Ki 67	Mus musculus	91-95
31441735-9	2020	Immunofluorescence analysis on proliferative marker Ki67 showed reduced expression on curcumin treatment in vitro.	Curcumin	86-94	antigen identified by monoclonal antibody Ki 67	Mus musculus	52-56
31441735-10	2020	The pathological sections from treated lungs showed significant decrease in EGFR and Ki67 levels when exposed to curcumin.	Curcumin	113-121	antigen identified by monoclonal antibody Ki 67	Mus musculus	85-89
31441735-11	2020	CONCLUSION: We conclude that curcumin, well-known natural bioactive compound holds strong anti-proliferative on Ki67 and EGFR expressions.We observed that, a clinical outcome in diagnosis of pulmonary fibrosis remains to be unconvincing so far.	Curcumin	29-37	antigen identified by monoclonal antibody Ki 67	Mus musculus	112-116
33124505-13	2020	Curcumin inhibited MMP9 expression, and silencing MMP9 suppressed sE-cad expression.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	19-23
32270742-4	2020	We hypothesized that SIRT1 is reduced in these cells in COPD, and that treatment with SIRT1 activators (resveratrol, curcumin) and agents preventing NAD depletion (theophylline) would upregulate SIRT1 and reduce pro-inflammatory cytokine expression in these steroid-resistant cells.	Curcumin	117-125	sirtuin 1	Homo sapiens	86-91
32270742-4	2020	We hypothesized that SIRT1 is reduced in these cells in COPD, and that treatment with SIRT1 activators (resveratrol, curcumin) and agents preventing NAD depletion (theophylline) would upregulate SIRT1 and reduce pro-inflammatory cytokine expression in these steroid-resistant cells.	Curcumin	117-125	sirtuin 1	Homo sapiens	86-91
32290922-1	2020	OBJECTIVE: To study the effect of curcumin on the expression of glucose regulated protein 78 kD(GRP78) and cysteinyl aspartate specific proteinase-12(caspase-12) of myocardial endoplasmic reticulum stress related factors in type 2 diabetes rats.	Curcumin	34-42	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	96-101
32290922-1	2020	OBJECTIVE: To study the effect of curcumin on the expression of glucose regulated protein 78 kD(GRP78) and cysteinyl aspartate specific proteinase-12(caspase-12) of myocardial endoplasmic reticulum stress related factors in type 2 diabetes rats.	Curcumin	34-42	caspase 12	Rattus norvegicus	150-160
32290922-11	2020	Compared with model group, FBG and LDH levels and HWI were reduced, the collagen fiber of intercellular space were decreased, the protein expression levels of GRP78 and caspase-12 were lowered in high dose of curcumin group(P<0.	Curcumin	209-217	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	159-164
32290922-11	2020	Compared with model group, FBG and LDH levels and HWI were reduced, the collagen fiber of intercellular space were decreased, the protein expression levels of GRP78 and caspase-12 were lowered in high dose of curcumin group(P<0.	Curcumin	209-217	caspase 12	Rattus norvegicus	169-179
31878265-5	2019	Western blot results showed that dietary supplementation with 200 mg/kg curcumin significantly increased the protein levels of Nrf2 and NQO1.	Curcumin	72-80	NAD(P)H quinone dehydrogenase 1	Sus scrofa	136-140
31654622-0	2019	Cytotoxicity of curcumin derivatives in ALK positive non-small cell lung cancer.	Curcumin	16-24	ALK receptor tyrosine kinase	Homo sapiens	40-43
31773117-7	2019	Furthermore, we also observed that the effect of curcumin on PPARgamma protein expression and NF-kappaB activation in CS-exposed rats was consistent with the results from experiments in vitro, and curcumin effectively attenuated pulmonary function decline and inflammatory responses in CS-exposed rats.	Curcumin	49-57	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	61-70
31773117-8	2019	In conclusion, all the results revealed that curcumin attenuated CS-induced inflammation both in vivo and in vitro, presumably by modulating the PPARgamma-NF-kappaB pathway.	Curcumin	45-53	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	145-154
31546365-7	2019	Optimized CUR nanoparticles with almost 70% drug entrapment, an average particle size of 58 nm, PDI &lt; 0.2, spherical nanostructures and sustained release profile were prepared.	Curcumin	10-13	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	96-99
31590042-0	2019	Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-kappaB pathways in BV2 cells.	Curcumin	0-8	triggering receptor expressed on myeloid cells 2	Mus musculus	92-97
31590042-14	2019	Curcumin treatment switched the M1 pro-inflammatory phenotype to the M2 anti-inflammatory phenotype by decreasing the expression of M1 markers (i.e., iNOS, IL-1beta, IL-6, and CD16/32) and elevating the expression of M2 markers (i.e., arginase 1, IL-4, IL-10, and CD206).	Curcumin	0-8	mannose receptor, C type 1	Mus musculus	264-269
31590042-15	2019	Interestingly, curcumin attenuated the activation of TLR4/NF-kappaB pathways and the downregulation of TREM2 expression in LPS-activated BV2 cells.	Curcumin	15-23	triggering receptor expressed on myeloid cells 2	Mus musculus	103-108
31590042-16	2019	Collectively, these results suggest that curcumin significantly alleviates LPS-induced inflammation by regulating microglial (M1/M2) polarization by reducing the imbalance of TREM2 and TLR4 and balancing the downstream NF-kappaB activation.	Curcumin	41-49	triggering receptor expressed on myeloid cells 2	Mus musculus	175-180
31247308-1	2019	This study aimed to evaluate nucleoside triphosphate diphosphohydrolase (NTPDase) and adenosine deaminase (ADA) activities in lymphocytes from rats supplemented or not with curcumin 30 days prior to experimental infection with Trypanosoma evansi.	Curcumin	173-181	adenosine deaminase	Rattus norvegicus	86-105
31247308-7	2019	The results showed that curcumin pre-treatment, with both doses, reduced (P &lt; .05) NTPDase and increased (P &lt; .05) ADA activity in lymphocytes of treated groups when compared to untreated and infected animals (control).	Curcumin	24-32	adenosine deaminase	Rattus norvegicus	121-124
31247308-8	2019	The results of this study support the evidence that the regulation of ATP and adenosine levels by NTPDase and ADA activities appear to be important to modulate the immune response in T. evansi infection, once the treatment with curcumin maintained the NTPDase activity reduced and enhanced ADA activity in lymphocytes.	Curcumin	228-236	adenosine deaminase	Rattus norvegicus	110-113
31247308-8	2019	The results of this study support the evidence that the regulation of ATP and adenosine levels by NTPDase and ADA activities appear to be important to modulate the immune response in T. evansi infection, once the treatment with curcumin maintained the NTPDase activity reduced and enhanced ADA activity in lymphocytes.	Curcumin	228-236	adenosine deaminase	Rattus norvegicus	290-293
31780732-0	2019	Curcumin enhances cisplatin-induced human laryngeal squamous cancer cell death through activation of TRPM2 channel and mitochondrial oxidative stress.	Curcumin	0-8	transient receptor potential cation channel subfamily M member 2	Homo sapiens	101-106
31819412-2	2019	The aim of this study was to assess the anti-inflammatory comparative effect of curcumin solution with liposomal curcumin formula, regarding the improvement of serum levels of TNF-alpha (tumor necrosis factor-alpha), IL-6 (interleukin), IL-1alpha, IL-1beta, MCP-1 (monocyte chemoattractant protein-1) and RANTES in experimental diabetes, induced by streptozotocin (STZ), in rats.	Curcumin	80-88	C-C motif chemokine ligand 5	Rattus norvegicus	305-311
31803007-10	2019	Meanwhile, curcumin treatment also decreased the expressions of TLR4, Myd88 and NF-kappaB at 24 h post SAH.	Curcumin	11-19	myeloid differentiation primary response gene 88	Mus musculus	70-75
31803007-13	2019	Our results indicated that curcumin treatment alleviated neuro-inflammation response through promoting microglia phenotype shift toward M2, and which might inhibiting TLR4/MyD88/NF-kappaB signaling pathway after SAH.	Curcumin	27-35	myeloid differentiation primary response gene 88	Mus musculus	172-177
31016760-7	2019	We found that curcumin treatment significantly reduced HMEC-1 cells viability, migration, and the protein levels of MMP-2, MMP-9, and vascular endothelial growth factor (VEGF) in the presence or absence of ox-LDL.	Curcumin	14-22	matrix metallopeptidase 9	Homo sapiens	123-128
31016760-8	2019	Meanwhile, the expression of VEGFR1 and VEGFR2 was repressed by curcumin.	Curcumin	64-72	kinase insert domain receptor	Homo sapiens	40-46
31665675-6	2019	Consistently, 2 weeks dietary intake of combined curcumin (500 mg/kg) and luteolin (500 mg/kg) in C57BL/6 mice synergistically prevented TNF-alpha-stimulated adhesion of mouse monocytes to aortic endothelium ex vivo as well as the TNF-alpha-increased aortic protein expression of MCP-1 and VCAM-1.	Curcumin	49-57	chemokine (C-C motif) ligand 2	Mus musculus	280-285
31340709-5	2019	Studying the mechanism of action indicated that OCT-modified curcumin plus docetaxel micelles downregulated MMP-2 and HIF-1alpha.	Curcumin	61-69	matrix metallopeptidase 2	Mus musculus	108-113
31872665-11	2019	The results of Western blot assay showed that the expression levels of i NOS and e NOS were decreased significantly in the model group,while the expression levels of i NOS and e NOS were increased significantly in the positive control group and curcumin groups.	Curcumin	245-253	nitric oxide synthase 3	Rattus norvegicus	176-181
31872665-12	2019	The results indicated that curcumin had a certain protective effect on the aorta of rats with metabolic syndrome and improves the aortic endothelial dysfunction,and its mechanism may be related to the fact that curcumin could reduce the production of oxygen free radicals and up-regulate the expression of i NOS and e NOS in aorta.	Curcumin	27-35	nitric oxide synthase 3	Rattus norvegicus	316-321
31872665-12	2019	The results indicated that curcumin had a certain protective effect on the aorta of rats with metabolic syndrome and improves the aortic endothelial dysfunction,and its mechanism may be related to the fact that curcumin could reduce the production of oxygen free radicals and up-regulate the expression of i NOS and e NOS in aorta.	Curcumin	211-219	nitric oxide synthase 3	Rattus norvegicus	316-321
31647008-0	2019	Curcumin ameliorates peritoneal fibrosis via inhibition of transforming growth factor-activated kinase 1 (TAK1) pathway in a rat model of peritoneal dialysis.	Curcumin	0-8	mitogen activated protein kinase kinase kinase 7	Rattus norvegicus	59-104
31647008-0	2019	Curcumin ameliorates peritoneal fibrosis via inhibition of transforming growth factor-activated kinase 1 (TAK1) pathway in a rat model of peritoneal dialysis.	Curcumin	0-8	mitogen activated protein kinase kinase kinase 7	Rattus norvegicus	106-110
31720046-7	2019	In addition, curcumin treatment in mice induced total Ab production as well as high affinity IgG1 and IgG2b Ab production.	Curcumin	13-21	LOC105243590	Mus musculus	93-97
31720046-7	2019	In addition, curcumin treatment in mice induced total Ab production as well as high affinity IgG1 and IgG2b Ab production.	Curcumin	13-21	immunoglobulin heavy constant gamma 2B	Mus musculus	102-107
31584928-0	2019	Curcumin Inhibits Cell Viability and Increases Apoptosis of SW620 Human Colon Adenocarcinoma Cells via the Caudal Type Homeobox-2 (CDX2)/Wnt/beta-Catenin Pathway.	Curcumin	0-8	caudal type homeobox 2	Homo sapiens	107-129
31584928-0	2019	Curcumin Inhibits Cell Viability and Increases Apoptosis of SW620 Human Colon Adenocarcinoma Cells via the Caudal Type Homeobox-2 (CDX2)/Wnt/beta-Catenin Pathway.	Curcumin	0-8	caudal type homeobox 2	Homo sapiens	131-135
31584928-9	2019	RESULTS Curcumin reduced cell viability and increased apoptosis of SW620 human colonic adenocarcinoma cells in a dose-dependent way, and increased the expression of CDX2 but decreased ss-catenin nuclear translocation and the expression of Wnt3a, c-Myc, survivin, and cyclin D1.	Curcumin	8-16	caudal type homeobox 2	Homo sapiens	165-169
31584928-10	2019	CDX2 silencing significantly reduced the effects of curcumin on SW620 human colonic adenocarcinoma cells.	Curcumin	52-60	caudal type homeobox 2	Homo sapiens	0-4
31584928-12	2019	CONCLUSIONS Curcumin reduced cell viability and increased apoptosis in SW620 human colonic adenocarcinoma cells by restoring CDX2, which inhibited the Wnt/ss-catenin signaling pathway.	Curcumin	12-20	caudal type homeobox 2	Homo sapiens	125-129
31454128-0	2019	Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro-inflammatory cytokines and Nrf2/Ho-1 pathway.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	173-177
31473513-10	2019	Intragastric administration of curcumin in SHR attenuated hypertension and reduced NFkappaB activation, NLRP3 and matrix metalloproteinase-9 expressions and aortic media thickness.	Curcumin	31-39	matrix metallopeptidase 9	Rattus norvegicus	114-140
31557970-6	2019	The exposure of neuroblastoma cells to curcumin induced: (a) up-regulation of GOLPH3+ cells; (b) augmentation of double-strand breaks; (c) Golgi fragmentation and dispersal throughout the cytoplasm; (d) increase of apoptosis and autophagy; (e) increased expression of TPX2 oncoprotein, able to repair DNA damage.	Curcumin	39-47	TPX2 microtubule nucleation factor	Homo sapiens	268-272
31554289-9	2019	Furthermore, dietary curcumin supplement linearly inhibited testicular apoptosis with increased testicular bcl-2 mRNA expression and decreased caspase-3 mRNA expression (p &lt; 0.05).	Curcumin	21-29	apoptosis regulator Bcl-2	Ovis aries	107-112
31514267-0	2019	The Therapeutic Effect of Curcumin in Quinolinic Acid-Induced Neurotoxicity in Rats is Associated with BDNF, ERK1/2, Nrf2, and Antioxidant Enzymes.	Curcumin	26-34	brain-derived neurotrophic factor	Rattus norvegicus	103-107
31514267-1	2019	In the present study we investigated the participation of brain-derived neurotropic factor (BDNF) on the activation of the mitogen activated protein kinase (MAPK) protein extracellular signal-regulated kinase-1/2 (ERK1/2) as a mechanism of curcumin (CUR) to provide an antioxidant defense system mediated by the nuclear factor erythroid 2-related factor 2 (Nrf2) in the neurotoxic model induced by quinolinic acid (QUIN).	Curcumin	240-248	brain-derived neurotrophic factor	Rattus norvegicus	58-90
31514267-1	2019	In the present study we investigated the participation of brain-derived neurotropic factor (BDNF) on the activation of the mitogen activated protein kinase (MAPK) protein extracellular signal-regulated kinase-1/2 (ERK1/2) as a mechanism of curcumin (CUR) to provide an antioxidant defense system mediated by the nuclear factor erythroid 2-related factor 2 (Nrf2) in the neurotoxic model induced by quinolinic acid (QUIN).	Curcumin	240-248	brain-derived neurotrophic factor	Rattus norvegicus	92-96
31480018-0	2019	Curcumin suppresses osteogenesis by inducing miR-126a-3p and subsequently suppressing the WNT/LRP6 pathway.	Curcumin	0-8	LDL receptor related protein 6	Homo sapiens	94-98
31516856-0	2019	Curcumin effects on myeloperoxidase, interleukin-18 and matrix metalloproteinase-9 inflammatory biomarkers in patients with unstable angina: A randomized clinical trial.	Curcumin	0-8	interleukin 18	Homo sapiens	37-51
31516856-0	2019	Curcumin effects on myeloperoxidase, interleukin-18 and matrix metalloproteinase-9 inflammatory biomarkers in patients with unstable angina: A randomized clinical trial.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	56-82
31705746-13	2019	Urinary NGAL test was significantly higher in patients with AKI (p=0.000), but there weren"t differences in its level in two groups (p=0.761)  Conclusion: It is appeared prophylactic oral Curcumin hasn"t protective effects on CIN in high risk patients who have undergone coronary procedure.	Curcumin	188-196	lipocalin 2	Homo sapiens	8-12
31592057-0	2019	Curcumin may induce lipolysis via proteo-stress in Huh7 human hepatoma cells.	Curcumin	0-8	MIR7-3 host gene	Homo sapiens	51-55
31592057-3	2019	In this study, we found that curcumin or heat shock treatment up-regulated the expression of adipose triglyceride lipase (ATGL) in Huh7 hepatoma cells, which resulted in acceleration of lipolysis.	Curcumin	29-37	MIR7-3 host gene	Homo sapiens	131-135
31592057-4	2019	Interestingly, perturbation of protein homeostasis was seen in curcumin-treated cells, as detected by formation of numerous ubiquitinated proteins and conjugated proteins with p62 (SQSTM).	Curcumin	63-71	nucleoporin 62	Homo sapiens	176-179
31592057-5	2019	Curcumin activated the protein expression of molecular chaperones, such as heat shock protein (HSP)40 and HSP70.	Curcumin	0-8	heat shock protein family A (Hsp70) member 4	Homo sapiens	106-111
31147008-0	2019	Targeting human brain cancer stem cells by curcumin-loaded nanoparticles grafted with anti-aldehyde dehydrogenase and sialic acid: Colocalization of ALDH and CD44.	Curcumin	43-51	CD44 molecule (Indian blood group)	Homo sapiens	158-162
31480578-5	2019	The Curcumin ASD demonstrated enhanced bioavailability by 11-fold and improved anti-inflammatory activities by the decrease in cytokine production (MMP-9, IL-1beta, IL-6, VEGF, MIP-2, and TNF-alpha) compared to the raw Curcumin.	Curcumin	4-12	matrix metallopeptidase 9	Homo sapiens	148-153
31472681-12	2019	Curcumin (20 muM) significantly suppressed PA- or TG-induced decrease in cell viability, caspase 3 activity, and the expression levels of BAX, CHOP, and GRP78.	Curcumin	0-8	caspase 3	Mus musculus	89-98
31497225-5	2019	In addition, FAS inhibitors, such as curcumin, ursolic acid, and resveratrol, have shown anti-cancer potential.	Curcumin	37-45	fatty acid synthase	Homo sapiens	13-16
30498979-10	2019	RESULTS: Curcumin and piperine increased the TGF-beta level, significantly improved the collagen repair, and decreased the cellularity and activation of NF-kB in the periodontal tissues, but only curcumin caused a significant increase in early bone repair.	Curcumin	9-17	transforming growth factor alpha	Rattus norvegicus	45-53
31034781-9	2019	In cultured renal tubular cells, myoglobin (Mb) induced ferroptosis-sensitive cell death that was also inhibited by curcumin.	Curcumin	116-124	myoglobin	Mus musculus	33-42
31034781-9	2019	In cultured renal tubular cells, myoglobin (Mb) induced ferroptosis-sensitive cell death that was also inhibited by curcumin.	Curcumin	116-124	myoglobin	Mus musculus	44-46
31034781-10	2019	Mechanistic in vitro studies showed that curcumin reduced Mb-mediated inflammation and oxidative stress by inhibiting the TLR4/NF-kappaB axis and activating the cytoprotective enzyme heme oxygenase 1.	Curcumin	41-49	myoglobin	Mus musculus	58-60
31011925-0	2019	Acute Lung Injury: IL-17A-Mediated Inflammatory Pathway and Its Regulation by Curcumin.	Curcumin	78-86	interleukin 17A	Homo sapiens	19-25
31028577-7	2019	Immunostaining studies have shown that curcumin pretreatment has significantly reduced matrix metalloproteinase-9 (MMP-9) expressions, which were elevated after PQ intoxication.	Curcumin	39-47	matrix metallopeptidase 9	Homo sapiens	87-113
31028577-7	2019	Immunostaining studies have shown that curcumin pretreatment has significantly reduced matrix metalloproteinase-9 (MMP-9) expressions, which were elevated after PQ intoxication.	Curcumin	39-47	matrix metallopeptidase 9	Homo sapiens	115-120
31466778-8	2019	The results of present study showed that heat stress curcumin treatment group had reduced inflammatory responses (IL-6, IL-1beta, TNF-alpha) as compared to HC and NC group.	Curcumin	53-61	interleukin 6	Gallus gallus	114-118
31257466-11	2019	Treatment with Jagged1 attenuated the effects of curcumin on cell viability, ROS levels and apoptosis; the Notch pathway was also reactivated.	Curcumin	49-57	jagged canonical Notch ligand 1	Rattus norvegicus	15-22
31029908-12	2019	Furthermore, the results revealed that both the total expression and nuclear accumulation of Nrf2, as well as its main downstream products such as HO-1, NQO1 and UGT, were decreased in the kidneys of mice in the crystal group, while treatment with curcumin could rescue this deterioration.	Curcumin	248-256	NAD(P)H dehydrogenase, quinone 1	Mus musculus	153-157
31206225-3	2019	Therefore, the aim of this study was to evaluate the effects of curcumin supplements on inflammation, oxidative stress, and chemerin levels in adolescent girls.	Curcumin	64-72	retinoic acid receptor responder 2	Homo sapiens	124-132
31534777-0	2019	Downregulation of RBBP6 variant 1 during arsenic trioxide-mediated cell cycle arrest and curcumin-induced apoptosis in MCF-7 breast cancer cells.	Curcumin	89-97	RB binding protein 6, ubiquitin ligase	Homo sapiens	18-23
31534777-1	2019	Aim: To determine the expression patterns of the RBBP6 spliced variants during arsenic trioxide-mediated cell cycle arrest and curcumin-induced apoptosis in MCF-7 cells.	Curcumin	127-135	RB binding protein 6, ubiquitin ligase	Homo sapiens	49-54
31534777-6	2019	Both As2O3 and curcumin significantly downregulated RBBP6 variant 1 (p &lt; 0.001).	Curcumin	15-23	RB binding protein 6, ubiquitin ligase	Homo sapiens	52-57
26455329-2	2015	Here, we fabricated a series of hyaluronic acid (HA)-functionalized camptothecin (CPT)/curcumin (CUR)-loaded polymeric NPs (HA-CPT/CUR-NPs) with various weight ratios of CPT to CUR (1 : 1, 2 : 1 and 4 : 1).	Curcumin	87-95	choline phosphotransferase 1	Homo sapiens	127-130
26464579-7	2015	Curcumin mediates several processes like restoration of CD4(+)/CD8(+) T cell populations, reversal of type-2 cytokine bias, reduction of Treg cell population and suppression of T cell apoptosis; all these help to resurrect tumor immune surveillance that leads to tumor regression.	Curcumin	0-8	CD8a molecule	Homo sapiens	63-66
27785305-5	2015	Since curcumin relaxed both cholecystokinin octapeptide- (CCK) and KCl-induced tension of guinea pig gallbladder strips in a concentration dependent manner, an in vitro technique was used to determine which second messenger system(s) mediated the observed relaxation.	Curcumin	6-14	cholecystokinin	Cavia porcellus	58-61
26300429-6	2015	The ability of curcumin and its conjugate to suppress the receptor activator of nuclear factor kappa B ligand-induced osteoclastogenesis was assessed by tartrate-resistant acid phosphatase (TRAP) staining and activity as well as real-time polymerase chain reaction.	Curcumin	15-23	TNF superfamily member 11	Homo sapiens	58-109
26220348-2	2015	We have previously reported that a natural product, curcumin, exhibited moderate inhibition and selectivity on 11beta-HSD1.	Curcumin	52-60	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	111-122
26220348-3	2015	By analyzing the models of protein, microsome, cells and GCs-induced mice in vitro and in vivo, this study presented a novel curcumin analog, LG13, as a potent selective 11beta-HSD1 inhibitor.	Curcumin	125-133	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	170-181
26190183-12	2015	In addition, curcumin also attenuated increased expression of GFAP and Iba-1 in animals with PTZ induced chronic epilepsy.	Curcumin	13-21	glial fibrillary acidic protein	Rattus norvegicus	62-66
26074474-8	2015	Treatment of curcumin effectively abrogated TS-triggered gastric activation of ERK1/2 and JNK MAPK pathways, AP-1 proteins, and EMT alterations.	Curcumin	13-21	mitogen-activated protein kinase 8	Mus musculus	90-93
26361331-5	2015	Flow cytometric analyses revealed that after intraperitoneal administration of the liposomes containing curcumin into mice, these were incorporated mainly by macrophages positive for F4/80, CD36, and CD11b antigens.	Curcumin	104-112	adhesion G protein-coupled receptor E1	Mus musculus	183-188
26361331-5	2015	Flow cytometric analyses revealed that after intraperitoneal administration of the liposomes containing curcumin into mice, these were incorporated mainly by macrophages positive for F4/80, CD36, and CD11b antigens.	Curcumin	104-112	integrin subunit alpha M	Homo sapiens	200-205
26617882-7	2015	The expression levels of CytC, Casp3 and Casp8 of the NASH livers were significantly higher than normal and NASH treated with curcumin rats livers.	Curcumin	126-134	caspase 8	Rattus norvegicus	41-46
26036622-5	2015	RESULTS: Our data showed that curcumin treatment not only decreased the expression of MMP-2 and MMP-9 to inhibit invasiveness in oral cancer but also modulated the expression of EMT markers, such as Snail, Twist, and E-cadherin, and induced p53 expression that is crucial to EMT repression.	Curcumin	30-38	matrix metallopeptidase 9	Homo sapiens	96-101
26317696-8	2015	Bnip3-TG mice underwent age-dependent ventricular dilation and heart failure that was partially prevented by p300 inhibition with curcumin.	Curcumin	130-138	E1A binding protein p300	Mus musculus	109-113
26066335-10	2015	Furthermore, curcumin decreases inflammatory cytokines interleukin 1beta and tumor necrosis factor alpha level, increases plasma brain-derived neurotrophic factor levels, and decreases salivary cortisol concentrations compared with placebo group.	Curcumin	13-21	brain derived neurotrophic factor	Homo sapiens	129-162
26059056-0	2015	Curcumin inhibits the invasion of lung cancer cells by modulating the PKCalpha/Nox-2/ROS/ATF-2/MMP-9 signaling pathway.	Curcumin	0-8	cytochrome b-245 beta chain	Homo sapiens	79-84
26059056-0	2015	Curcumin inhibits the invasion of lung cancer cells by modulating the PKCalpha/Nox-2/ROS/ATF-2/MMP-9 signaling pathway.	Curcumin	0-8	activating transcription factor 2	Homo sapiens	89-94
26059056-0	2015	Curcumin inhibits the invasion of lung cancer cells by modulating the PKCalpha/Nox-2/ROS/ATF-2/MMP-9 signaling pathway.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	95-100
26059056-12	2015	Finally, we also showed that curcumin dose-dependently reduced the expression of PKCalpha, P47phox, Nox-2 and phosphorylated ATF-2, as well as intracellular ROS generation, suggesting the inhibitory effect of curcumin on the activation of the PKCalpha/Nox-2/ROS/ATF-2 pathway.	Curcumin	29-37	neutrophil cytosolic factor 1	Homo sapiens	91-98
26059056-12	2015	Finally, we also showed that curcumin dose-dependently reduced the expression of PKCalpha, P47phox, Nox-2 and phosphorylated ATF-2, as well as intracellular ROS generation, suggesting the inhibitory effect of curcumin on the activation of the PKCalpha/Nox-2/ROS/ATF-2 pathway.	Curcumin	29-37	cytochrome b-245 beta chain	Homo sapiens	100-105
26059056-12	2015	Finally, we also showed that curcumin dose-dependently reduced the expression of PKCalpha, P47phox, Nox-2 and phosphorylated ATF-2, as well as intracellular ROS generation, suggesting the inhibitory effect of curcumin on the activation of the PKCalpha/Nox-2/ROS/ATF-2 pathway.	Curcumin	29-37	activating transcription factor 2	Homo sapiens	125-130
26059056-12	2015	Finally, we also showed that curcumin dose-dependently reduced the expression of PKCalpha, P47phox, Nox-2 and phosphorylated ATF-2, as well as intracellular ROS generation, suggesting the inhibitory effect of curcumin on the activation of the PKCalpha/Nox-2/ROS/ATF-2 pathway.	Curcumin	29-37	cytochrome b-245 beta chain	Homo sapiens	252-257
26059056-12	2015	Finally, we also showed that curcumin dose-dependently reduced the expression of PKCalpha, P47phox, Nox-2 and phosphorylated ATF-2, as well as intracellular ROS generation, suggesting the inhibitory effect of curcumin on the activation of the PKCalpha/Nox-2/ROS/ATF-2 pathway.	Curcumin	29-37	activating transcription factor 2	Homo sapiens	262-267
26059056-12	2015	Finally, we also showed that curcumin dose-dependently reduced the expression of PKCalpha, P47phox, Nox-2 and phosphorylated ATF-2, as well as intracellular ROS generation, suggesting the inhibitory effect of curcumin on the activation of the PKCalpha/Nox-2/ROS/ATF-2 pathway.	Curcumin	209-217	cytochrome b-245 beta chain	Homo sapiens	252-257
26059056-12	2015	Finally, we also showed that curcumin dose-dependently reduced the expression of PKCalpha, P47phox, Nox-2 and phosphorylated ATF-2, as well as intracellular ROS generation, suggesting the inhibitory effect of curcumin on the activation of the PKCalpha/Nox-2/ROS/ATF-2 pathway.	Curcumin	209-217	activating transcription factor 2	Homo sapiens	262-267
25744732-9	2015	Diclofenac and curcumin overcome these carcinogenic effects by downregulating telomerase activity, diminishing the expression of TERT, CDK4, CDK2, cyclin D1, and cyclin E.	Curcumin	15-23	telomerase reverse transcriptase	Rattus norvegicus	129-133
25744732-9	2015	Diclofenac and curcumin overcome these carcinogenic effects by downregulating telomerase activity, diminishing the expression of TERT, CDK4, CDK2, cyclin D1, and cyclin E.	Curcumin	15-23	cyclin dependent kinase 2	Rattus norvegicus	141-145
25744732-10	2015	The anticarcinogenic effects shown after the inhibition of telomerase activity by diclofenac and curcumin may be associated with upregulation of tumor suppressor proteins p51, Rb, and p21, whose activation induces the cells cycle arrest and apoptosis.	Curcumin	97-105	KRAS proto-oncogene, GTPase	Rattus norvegicus	184-187
26252085-0	2015	[Effect of curcumin on oligomer formation and mitochondrial ATP-sensitive potassium channels induced by overexpression or mutation of alpha-synuclein].	Curcumin	11-19	synuclein alpha	Rattus norvegicus	134-149
26252085-1	2015	OBJECTIVE: To investigate the effect of curcumin on oligomer formation and mitochondrial ATP-sensitive potassium channels (mitoKATP) induced by overexpression or mutation of alpha-synuclein.	Curcumin	40-48	synuclein alpha	Rattus norvegicus	174-189
26252085-6	2015	RESULTS: Curcumin has significantly reduced the oligomer formation induced by overexpression or mutation of alpha-synuclein in the cultured cells.	Curcumin	9-17	synuclein alpha	Rattus norvegicus	108-123
26252085-9	2015	CONCLUSION: Curcumin can inhibit alpha-synuclein gene overexpression or mutation induced alpha-synuclein oligomers formation.	Curcumin	12-20	synuclein alpha	Rattus norvegicus	33-48
26252085-9	2015	CONCLUSION: Curcumin can inhibit alpha-synuclein gene overexpression or mutation induced alpha-synuclein oligomers formation.	Curcumin	12-20	synuclein alpha	Rattus norvegicus	89-104
26227888-7	2015	Curcumin alone was able to reverse all the parameters investigated in this study that govern inflammatory responses, CD8(+) T cell and pRBC sequestration into the brain and blood brain barrier (BBB) breakdown.	Curcumin	0-8	CD8a molecule	Homo sapiens	117-120
26124332-6	2015	Curcumin reduced expression of DNA-repair proteins such as 14-3-3 protein sigma (14-3-3sigma), O6-methylguanine-DNA methyltransferase (MGMT), breast cancer susceptibility gene 1 (BRCA1), and mediator of DNA damage checkpoint 1 (MDC1).	Curcumin	0-8	O-6-methylguanine-DNA methyltransferase	Homo sapiens	95-133
26124332-6	2015	Curcumin reduced expression of DNA-repair proteins such as 14-3-3 protein sigma (14-3-3sigma), O6-methylguanine-DNA methyltransferase (MGMT), breast cancer susceptibility gene 1 (BRCA1), and mediator of DNA damage checkpoint 1 (MDC1).	Curcumin	0-8	O-6-methylguanine-DNA methyltransferase	Homo sapiens	135-139
26124332-6	2015	Curcumin reduced expression of DNA-repair proteins such as 14-3-3 protein sigma (14-3-3sigma), O6-methylguanine-DNA methyltransferase (MGMT), breast cancer susceptibility gene 1 (BRCA1), and mediator of DNA damage checkpoint 1 (MDC1).	Curcumin	0-8	BRCA1 DNA repair associated	Homo sapiens	179-184
26124332-6	2015	Curcumin reduced expression of DNA-repair proteins such as 14-3-3 protein sigma (14-3-3sigma), O6-methylguanine-DNA methyltransferase (MGMT), breast cancer susceptibility gene 1 (BRCA1), and mediator of DNA damage checkpoint 1 (MDC1).	Curcumin	0-8	mediator of DNA damage checkpoint 1	Homo sapiens	191-226
26124332-6	2015	Curcumin reduced expression of DNA-repair proteins such as 14-3-3 protein sigma (14-3-3sigma), O6-methylguanine-DNA methyltransferase (MGMT), breast cancer susceptibility gene 1 (BRCA1), and mediator of DNA damage checkpoint 1 (MDC1).	Curcumin	0-8	mediator of DNA damage checkpoint 1	Homo sapiens	228-232
25874494-6	2015	Downregulation of lymphatic vessel endothelial receptor 1 (LYVE-1), Prox-1, podoplanin, and VEGFR-3 mRNA expression by curcumin was also detected (all P &lt; 0.05).	Curcumin	119-127	fms related receptor tyrosine kinase 4	Homo sapiens	92-99
26114940-7	2015	In addition, the beneficial effect of curcumin is accompanied by increased BDNF levels and elevated levels of phosphorylated ERK in the hippocampus.	Curcumin	38-46	brain-derived neurotrophic factor	Rattus norvegicus	75-79
26114940-8	2015	Furthermore, the cognition enhancement effect of curcumin could be mimicked by the overexpression of BDNF in the hippocampus and blocked by either bilateral hippocampal injections with lentiviruses that express BDNF shRNA or a microinjection of ERK inhibitor.	Curcumin	49-57	brain-derived neurotrophic factor	Rattus norvegicus	101-105
26114940-8	2015	Furthermore, the cognition enhancement effect of curcumin could be mimicked by the overexpression of BDNF in the hippocampus and blocked by either bilateral hippocampal injections with lentiviruses that express BDNF shRNA or a microinjection of ERK inhibitor.	Curcumin	49-57	brain-derived neurotrophic factor	Rattus norvegicus	211-215
26114940-9	2015	These findings suggest that chronic curcumin ameliorates AD-related cognitive deficits and that upregulated BDNF-ERK signaling in the hippocampus may underlie the cognitive improvement produced by curcumin.	Curcumin	197-205	brain-derived neurotrophic factor	Rattus norvegicus	108-112
26309628-0	2015	Curcumin inhibits proliferation of interleukin-22-treated HaCaT cells.	Curcumin	0-8	interleukin 22	Homo sapiens	35-49
26309628-2	2015	In this study, we investigated effects of curcumin on IL-22-induced proliferation in a human keratinocyte cell line (HaCaT) in vitro experiment.	Curcumin	42-50	interleukin 22	Homo sapiens	54-59
26309628-6	2015	Our results show that curcumin exhibited a significant anti-proliferation effect on HaCaT cells, even in the presence of IL-22.	Curcumin	22-30	interleukin 22	Homo sapiens	121-126
26309628-8	2015	As expected, curcumin inhibited IL-22 induced phosphorylation of STAT3; furthermore, curcumin down regulated cyclin D1 and cyclin E. We can reach a conclusion that curcumin can suppress the proliferation of keratinocytes even with IL-22 treatment.	Curcumin	13-21	interleukin 22	Homo sapiens	32-37
26309628-8	2015	As expected, curcumin inhibited IL-22 induced phosphorylation of STAT3; furthermore, curcumin down regulated cyclin D1 and cyclin E. We can reach a conclusion that curcumin can suppress the proliferation of keratinocytes even with IL-22 treatment.	Curcumin	13-21	interleukin 22	Homo sapiens	231-236
26309628-8	2015	As expected, curcumin inhibited IL-22 induced phosphorylation of STAT3; furthermore, curcumin down regulated cyclin D1 and cyclin E. We can reach a conclusion that curcumin can suppress the proliferation of keratinocytes even with IL-22 treatment.	Curcumin	85-93	interleukin 22	Homo sapiens	32-37
26309628-8	2015	As expected, curcumin inhibited IL-22 induced phosphorylation of STAT3; furthermore, curcumin down regulated cyclin D1 and cyclin E. We can reach a conclusion that curcumin can suppress the proliferation of keratinocytes even with IL-22 treatment.	Curcumin	85-93	interleukin 22	Homo sapiens	231-236
26309628-8	2015	As expected, curcumin inhibited IL-22 induced phosphorylation of STAT3; furthermore, curcumin down regulated cyclin D1 and cyclin E. We can reach a conclusion that curcumin can suppress the proliferation of keratinocytes even with IL-22 treatment.	Curcumin	85-93	interleukin 22	Homo sapiens	32-37
26309628-8	2015	As expected, curcumin inhibited IL-22 induced phosphorylation of STAT3; furthermore, curcumin down regulated cyclin D1 and cyclin E. We can reach a conclusion that curcumin can suppress the proliferation of keratinocytes even with IL-22 treatment.	Curcumin	85-93	interleukin 22	Homo sapiens	231-236
26048285-5	2015	Curcumin prophylaxis significantly attenuated the upregulation of NF-kappaB (p &lt; 0.001), thereby leading to concomitant downregulation of pro-inflammatory cytokine levels ( IL-1, IL-2, IL-18 and TNF-alpha), cell adhesion molecules ( P-selectin and E-selectin) and increased anti-inflammatory cytokine ( IL-10).	Curcumin	0-8	selectin E	Rattus norvegicus	251-261
26048285-6	2015	Curcumin stabilized the brain HIF-1alpha levels followed by maintaining VEGF levels along with upregulated Na(+)/K(+)-ATPase and ENaC levels (p &lt; 0.001) under hypoxia.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	30-40
26048285-7	2015	Curcumin restored the brain ZO-1, JAMC, claudin 4 and claudin 5 levels (p &lt; 0.001) under hypoxia.	Curcumin	0-8	junctional adhesion molecule 3	Rattus norvegicus	34-38
26261622-12	2015	Application of curcumin can inhibit expression of MMP-9, CD40L, TNF-alpha and CRP to improve the permeability of coronary artery.	Curcumin	15-23	matrix metallopeptidase 9	Rattus norvegicus	50-55
25846484-6	2015	Nanocurcumin ameliorated hypoxia-induced hypertrophy and apoptosis in H9c2 cells significantly (p &lt;= 0.01), by downregulating atrial natriuretic factor expression, caspase-3/-7 activation, oxidative stress and stabilizing hypoxia-inducible factor-1alpha (HIF-1alpha) better than curcumin.	Curcumin	4-12	natriuretic peptide A	Rattus norvegicus	129-154
25846484-6	2015	Nanocurcumin ameliorated hypoxia-induced hypertrophy and apoptosis in H9c2 cells significantly (p &lt;= 0.01), by downregulating atrial natriuretic factor expression, caspase-3/-7 activation, oxidative stress and stabilizing hypoxia-inducible factor-1alpha (HIF-1alpha) better than curcumin.	Curcumin	4-12	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	225-256
25846484-6	2015	Nanocurcumin ameliorated hypoxia-induced hypertrophy and apoptosis in H9c2 cells significantly (p &lt;= 0.01), by downregulating atrial natriuretic factor expression, caspase-3/-7 activation, oxidative stress and stabilizing hypoxia-inducible factor-1alpha (HIF-1alpha) better than curcumin.	Curcumin	4-12	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	258-268
25673156-6	2015	However, curcumin significantly suppressed the levels of H/R-induced apoptosis (expression of annexin V) and autophagy (LC3B-II/LC3B-I ratio) in the H9c2 myocytes and promoted cell survival.	Curcumin	9-17	annexin A5	Rattus norvegicus	94-103
25673156-9	2015	These findings suggested that the protective effect of curcumin against H/R injury in the H9c2 myocytes was through the inhibition of apoptosis and autophagy by inducing the expression of Bcl-2 and inhibiting the expression levels of Bax, beclin-1, BNIP3 and SIRT1.	Curcumin	55-63	beclin 1	Homo sapiens	239-247
25673156-9	2015	These findings suggested that the protective effect of curcumin against H/R injury in the H9c2 myocytes was through the inhibition of apoptosis and autophagy by inducing the expression of Bcl-2 and inhibiting the expression levels of Bax, beclin-1, BNIP3 and SIRT1.	Curcumin	55-63	sirtuin 1	Homo sapiens	259-264
26108778-9	2015	CONCLUSION: Radiation sensitization effect of curcumin on colorectal cancer cells HT-29 may be associated with the regulation of genes of CCNH, LIG4, XRCC5, PNKP.	Curcumin	46-54	polynucleotide kinase 3'-phosphatase	Homo sapiens	157-161
26013662-8	2015	In addition, curcumin induced ER stress by triggering ROS generation, which was supported by the finding that treating cells with the antioxidant NAC alleviated curcumin-mediated ER stress and vacuolation-mediated death.	Curcumin	13-21	X-linked Kx blood group	Homo sapiens	146-149
26013662-8	2015	In addition, curcumin induced ER stress by triggering ROS generation, which was supported by the finding that treating cells with the antioxidant NAC alleviated curcumin-mediated ER stress and vacuolation-mediated death.	Curcumin	161-169	X-linked Kx blood group	Homo sapiens	146-149
25730179-11	2015	Curcumin treatment exerted anti-apoptosis and anti-oxidative effects by up-regulating Nrf2/HO-1 and Sirt1 expression.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	91-95
25682767-0	2015	Curcumin relieves TPA-induced Th1 inflammation in K14-VEGF transgenic mice.	Curcumin	0-8	vascular endothelial growth factor A	Mus musculus	54-58
25644785-10	2015	Diclofenac and Curcumin showed anti-neoplastic effects by downregulating PI3-K/Akt/PTEN pathway, inducing apoptosis, increasing ROS generation, and decreasing DeltaPsi M. The anti-neoplastic and apoptotic effects were found enhanced when both Diclofenac and Curcumin were administered together, rather than individually.	Curcumin	15-23	phosphatase and tensin homolog	Rattus norvegicus	83-87
26043573-0	2015	[Curcumin inhibited rat colorectal carcinogenesis by activating PPAR-gamma: an experimental study].	Curcumin	1-9	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	64-74
26043573-6	2015	The effect of curcumin on the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in rat colon mucosal tissues was observed using immunohistochemistry and Western blot.	Curcumin	14-22	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	44-92
26043573-6	2015	The effect of curcumin on the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in rat colon mucosal tissues was observed using immunohistochemistry and Western blot.	Curcumin	14-22	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	94-103
26043573-16	2015	Compared with the normal control group, the expression of PPARgamma protein was significantly increased in the curcumin group and the model group (P &lt;0.	Curcumin	111-119	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	58-67
26043573-23	2015	Compared with the GW9662 group, the expression of PPARgamma protein was significantly increased in the curcumin group (P &lt;0.	Curcumin	103-111	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	50-59
25786122-7	2015	Expression of downstream effectors of TGF-beta signaling pathway, cyclinD1, p21 and Pin1, was inhibited along with the down regulation of key mesenchymal markers (Snail and Slug) upon curcumin and emodin treatment.	Curcumin	184-192	snail family transcriptional repressor 2	Homo sapiens	173-177
25879655-10	2015	Furthermore, BRCA1 was found at the viral promoter and treatment with curcumin and ATM inhibitors decreased BRCA1 LTR occupancy.	Curcumin	70-78	BRCA1 DNA repair associated	Homo sapiens	13-18
25879655-10	2015	Furthermore, BRCA1 was found at the viral promoter and treatment with curcumin and ATM inhibitors decreased BRCA1 LTR occupancy.	Curcumin	70-78	BRCA1 DNA repair associated	Homo sapiens	108-113
25526088-2	2015	Here we show that this applies to anacardic acid, curcumin, garcinol and spermidine, all of which reduce the acetylation level of cultured human cells as they induce signs of increased autophagic flux (such as the formation of green fluorescent protein-microtubule-associated protein 1A/1B-light chain 3 (GFP-LC3) puncta and the depletion of sequestosome-1, p62/SQSTM1) coupled to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).	Curcumin	50-58	sequestosome 1	Homo sapiens	342-356
25526088-2	2015	Here we show that this applies to anacardic acid, curcumin, garcinol and spermidine, all of which reduce the acetylation level of cultured human cells as they induce signs of increased autophagic flux (such as the formation of green fluorescent protein-microtubule-associated protein 1A/1B-light chain 3 (GFP-LC3) puncta and the depletion of sequestosome-1, p62/SQSTM1) coupled to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).	Curcumin	50-58	sequestosome 1	Homo sapiens	358-361
25526088-2	2015	Here we show that this applies to anacardic acid, curcumin, garcinol and spermidine, all of which reduce the acetylation level of cultured human cells as they induce signs of increased autophagic flux (such as the formation of green fluorescent protein-microtubule-associated protein 1A/1B-light chain 3 (GFP-LC3) puncta and the depletion of sequestosome-1, p62/SQSTM1) coupled to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).	Curcumin	50-58	sequestosome 1	Homo sapiens	362-368
25868812-3	2015	The docking results demonstrated that curcumin has good binding affinity towards CD28 and CD45 receptors as compared to piperine but in vitro studies revealed that piperine is more effective.	Curcumin	38-46	protein tyrosine phosphatase receptor type C	Homo sapiens	90-94
25602852-3	2015	Further research on its underlying mechanism showed that curcumin suppressed transition of the cells from G1 to S phase and enhanced the expression of Sox4, Sox2, and Oct4, which were essential to retain the stemness properties of glioma-initiating cells.	Curcumin	57-65	SRY-box transcription factor 4	Homo sapiens	151-155
25602852-3	2015	Further research on its underlying mechanism showed that curcumin suppressed transition of the cells from G1 to S phase and enhanced the expression of Sox4, Sox2, and Oct4, which were essential to retain the stemness properties of glioma-initiating cells.	Curcumin	57-65	SRY-box transcription factor 2	Homo sapiens	157-161
25444916-12	2015	Taken together, this study highlights that the proapoptotic effects of curcumin depend on miR-192-5p/215 induction and the p53-miR-192-5p/215-XIAP pathway is an important therapeutic target for non-small cell lung cancer.	Curcumin	71-79	X-linked inhibitor of apoptosis	Homo sapiens	142-146
25359171-4	2015	Interestingly, separate as well as combined supplementation of curcumin (60 mg/kg body weight) and quercetin (40 mg/kg body weight) to BP-treated animals resulted in a significant decrease in the protein expression of Bcl-2 but caused a significant increase in the protein expression of Bax along with a noticeable improvement in the number of apoptotic cells.	Curcumin	63-71	BCL2-associated X protein	Mus musculus	287-290
25359171-5	2015	Also, supplementation with curcumin and quercetin separately to BP-treated mice brought a significant improvement in the enzyme activities of caspase 9 as well as caspase 3 but the improvement was more pronounced following combined treatment.	Curcumin	27-35	caspase 3	Mus musculus	163-172
25451013-7	2015	Through comprehensive proteomic analysis, three of the tested compounds, oxaliplatin, ginsenoside 20(S)-Rg3 and curcumin, were revealed to have a suppressive effect on FASN and histone H4 expression.	Curcumin	112-120	fatty acid synthase	Homo sapiens	168-172
25451013-7	2015	Through comprehensive proteomic analysis, three of the tested compounds, oxaliplatin, ginsenoside 20(S)-Rg3 and curcumin, were revealed to have a suppressive effect on FASN and histone H4 expression.	Curcumin	112-120	H4 clustered histone 9	Homo sapiens	177-187
25451013-12	2015	Three tested drugs, namely, oxaliplatin, ginsenoside 20(S)-Rg3 and curcumin were revealed to possess suppressive effects on fatty acid synthase and histone H4 and reduce metastasis as determined by cell migration assay.	Curcumin	67-75	H4 clustered histone 9	Homo sapiens	148-158
25991545-11	2015	Tc-99m-HYNIC-VEGF-c-SPECT imaging showed decreased uptake to the tumor, which may indicate a lower expression of VEGFR2/3 in curcumin treated tumors; however, a statistically significant difference was not achieved (p&gt;0.05).	Curcumin	125-133	kinase insert domain receptor	Homo sapiens	113-119
25824783-0	2015	Dendrosomal curcumin inhibits metastatic potential of human SW480 colon cancer cells through Down-regulation of Claudin1, Zeb1 and Hef1-1 gene expression.	Curcumin	12-20	claudin 1	Homo sapiens	112-120
25824783-0	2015	Dendrosomal curcumin inhibits metastatic potential of human SW480 colon cancer cells through Down-regulation of Claudin1, Zeb1 and Hef1-1 gene expression.	Curcumin	12-20	zinc finger E-box binding homeobox 1	Homo sapiens	122-126
25446993-0	2015	Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation.	Curcumin	6-14	mitogen-activated protein kinase 8	Mus musculus	60-63
25446993-0	2015	Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation.	Curcumin	6-14	E1A binding protein p300	Mus musculus	96-100
25446993-0	2015	Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation.	Curcumin	6-14	CREB binding protein	Mus musculus	101-104
25446993-2	2015	To investigate whether the plant metabolite curcumin, which exerts epigenetic modulatory properties when applied as a pharmacological agent, may prevent DN via inhibition of the JNK pathway and epigenetic histone acetylation, diabetic and age-matched non-diabetic control mice were administered a 3-month course of curcumin analogue (C66), c-Jun N-terminal kinase inhibitor (JNKi, sp600125), or vehicle alone.	Curcumin	44-52	mitogen-activated protein kinase 8	Mus musculus	178-181
26235577-0	2015	Curcumin Attenuates Hydrogen Peroxide-Induced Premature Senescence via the Activation of SIRT1 in Human Umbilical Vein Endothelial Cells.	Curcumin	0-8	sirtuin 1	Homo sapiens	89-94
26235577-9	2015	Treatment with curcumin alone enhanced the enzymatic activity of SIRT1, but didn"t affect cellular senescence, cell growth or apoptosis compared to the Control.	Curcumin	15-23	sirtuin 1	Homo sapiens	65-70
26235577-10	2015	The inhibition of SIRT1 using SIRT1 short interfering RNA (siRNA) could decrease the expression and phosphorylation of eNOS and abrogate the protective effect of curcumin on H2O2-induced premature senescence.	Curcumin	162-170	sirtuin 1	Homo sapiens	18-23
26235577-10	2015	The inhibition of SIRT1 using SIRT1 short interfering RNA (siRNA) could decrease the expression and phosphorylation of eNOS and abrogate the protective effect of curcumin on H2O2-induced premature senescence.	Curcumin	162-170	sirtuin 1	Homo sapiens	30-35
26235577-11	2015	These findings suggest that curcumin could attenuate oxidative stress-induced HUVECs" premature senescence via the activation of SIRT1.	Curcumin	28-36	sirtuin 1	Homo sapiens	129-134
25333322-0	2015	Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells.	Curcumin	0-8	elastin	Homo sapiens	83-90
25333322-2	2015	In this presented study, we found that curcumin can enhance the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells via increasing ELN and FBN1 promoters" activities.	Curcumin	39-47	elastin	Homo sapiens	125-132
25333322-2	2015	In this presented study, we found that curcumin can enhance the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells via increasing ELN and FBN1 promoters" activities.	Curcumin	39-47	elastin	Homo sapiens	199-202
25333322-3	2015	With 2 muM curcumin treatment, the enhanced tropoelastin and fibrillin-1 protein amounts in Detroit 551 cells were approximately 134 and 130% of control, respectively.	Curcumin	11-19	elastin	Homo sapiens	44-56
26862311-8	2015	RESULTS: Administration of low doses of curcumin (0.1 and 1 microg/ml) could decrease Th17 percentages (p = 0.000 and p = 0.000 compared to control), reduce IL-17A productions (p = 0.000 and p = 0.000 compared to control), increase Treg percentages (p = 0.001 and p = 0.000 compared to control), and increase TGF-beta1 productions (p = 0.001 and p = 0.000 compared to control) on CD4+ T cells of SLE patients.	Curcumin	40-48	interleukin 17A	Homo sapiens	157-163
26626244-6	2015	The pretreatment by curcumin not only negated the accelerated cell death and apoptosis caused by TNF and CHX, but also diminished TNF-induced cell activation, as assessed by reduced surface expression of intercellular adhesion molecule 1, and adhesion of monocytes to endothelial monolayers.	Curcumin	20-28	intercellular adhesion molecule 1	Homo sapiens	204-237
25435978-1	2015	The aim of the present study was to explore the effects of curcumin in combination with bevacizumab on the vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)/K-ras pathway in hepatocellular carcinoma.	Curcumin	59-67	KRAS proto-oncogene, GTPase	Rattus norvegicus	171-176
25431425-12	2014	Furthermore, curcumin treatment greatly reduced phosphorylation of CREB, followed by a concomitant reduction of NF-kappaB (p50 and p65) subunit activation.	Curcumin	13-21	cAMP responsive element binding protein 1	Homo sapiens	67-71
25256401-0	2014	Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells.	Curcumin	0-8	leukocyte immunoglobulin like receptor B1	Homo sapiens	68-73
25256401-4	2014	In this study, we explored whether curcumin regulates miR-7, leading to the inhibition of cell growth, migration and invasion in pancreatic cancer cells.	Curcumin	35-43	leukocyte immunoglobulin like receptor B1	Homo sapiens	54-59
25256401-5	2014	We observed that curcumin suppressed cell growth, migration and invasion, and induced cell apoptosis, which is associated with increased expression of miR-7 and subsequently decreased expression of SET8, one of the miR-7 targets.	Curcumin	17-25	leukocyte immunoglobulin like receptor B1	Homo sapiens	151-156
25256401-5	2014	We observed that curcumin suppressed cell growth, migration and invasion, and induced cell apoptosis, which is associated with increased expression of miR-7 and subsequently decreased expression of SET8, one of the miR-7 targets.	Curcumin	17-25	leukocyte immunoglobulin like receptor B1	Homo sapiens	215-220
25256401-6	2014	These findings demonstrated that targeting miR-7 by curcumin could be a novel strategy for the treatment of pancreatic cancer.	Curcumin	52-60	leukocyte immunoglobulin like receptor B1	Homo sapiens	43-48
25172633-7	2014	In studies of the mechanism of curcumin-induced apoptosis in SF-767 cells, its effect on the subcellular location of p14(ARF) was determined.	Curcumin	31-39	ribonuclease P/MRP subunit p14	Homo sapiens	117-120
25172633-8	2014	Whereas p14(ARF) was confined to the nucleolus in untreated cells, 2 h following incubation with curcumin, it displayed a diffuse nuclear distribution.	Curcumin	97-105	ribonuclease P/MRP subunit p14	Homo sapiens	8-11
25172633-10	2014	Between 2 and 4 h following curcumin treatment, p53 levels increased with maximum levels reached by 8 h. Thus, curcumin homing to the nucleolus induces redistribution of p14(ARF) to the nucleoplasm where interaction with MDM2 leads to stabilization of p53, with subsequent initiation of apoptosis.	Curcumin	28-36	ribonuclease P/MRP subunit p14	Homo sapiens	170-173
25172633-10	2014	Between 2 and 4 h following curcumin treatment, p53 levels increased with maximum levels reached by 8 h. Thus, curcumin homing to the nucleolus induces redistribution of p14(ARF) to the nucleoplasm where interaction with MDM2 leads to stabilization of p53, with subsequent initiation of apoptosis.	Curcumin	28-36	MDM2 proto-oncogene	Homo sapiens	221-225
25172633-10	2014	Between 2 and 4 h following curcumin treatment, p53 levels increased with maximum levels reached by 8 h. Thus, curcumin homing to the nucleolus induces redistribution of p14(ARF) to the nucleoplasm where interaction with MDM2 leads to stabilization of p53, with subsequent initiation of apoptosis.	Curcumin	111-119	ribonuclease P/MRP subunit p14	Homo sapiens	170-173
25172633-10	2014	Between 2 and 4 h following curcumin treatment, p53 levels increased with maximum levels reached by 8 h. Thus, curcumin homing to the nucleolus induces redistribution of p14(ARF) to the nucleoplasm where interaction with MDM2 leads to stabilization of p53, with subsequent initiation of apoptosis.	Curcumin	111-119	MDM2 proto-oncogene	Homo sapiens	221-225
25282128-9	2014	Curcumin reduced the mRNA and protein expression of intracellular adhesion molecule-1, vascular cell adhesion molecule-1, P-selectin, and monocyte chemotactic protein-1, and it inhibited HCD-induced up-regulation of MMP-1, MMP-2, and MMP-9.	Curcumin	0-8	C-C motif chemokine 2	Oryctolagus cuniculus	138-168
30478904-5	2019	We detected that quercetin and curcumin dose-dependently enhanced the BRCA1 expression.	Curcumin	31-39	BRCA1 DNA repair associated	Homo sapiens	70-75
30478904-6	2019	Further, a synergistic action of quercetin and curcumin was observed in modulating the BRCA1 level and in inhibiting the cell survival and migration of TNBC cell lines.	Curcumin	47-55	BRCA1 DNA repair associated	Homo sapiens	87-92
30478904-7	2019	Quercetin and curcumin appeared to induce BRCA1 promoter histone acetylation.	Curcumin	14-22	BRCA1 DNA repair associated	Homo sapiens	42-47
30478904-8	2019	Furthermore, BRCA1 knockdown induced cell survival and cell migration in ER + cells were significantly decreased by the combined treatment of quercetin and curcumin.	Curcumin	156-164	BRCA1 DNA repair associated	Homo sapiens	13-18
30951849-10	2019	We conclude that curcumin is an immunomodulatory treatment capable of emulating anti-Abeta vaccine in stimulating phagocytic clearance of amyloid by reducing CD33 and increasing TREM2 and TyroBP, while restoring neuroinflammatory networks implicated in neurodegenerative diseases.	Curcumin	17-25	TYRO protein tyrosine kinase binding protein	Mus musculus	188-194
31602860-7	2019	Moreover,curcumin could inhibit the migration and invasion of MKN45 cells,downregulate the expression of N-cadherin,snail1,Wnt3 a,p-beta-catenin,p-LRP6 and Bcl-2,and upregulate the expression of E-cadherin and Bax,it could increase the activity of caspase-3,caspase-8,caspase-9 and induce apoptosis as well.	Curcumin	9-17	cadherin 2	Homo sapiens	105-115
31602860-7	2019	Moreover,curcumin could inhibit the migration and invasion of MKN45 cells,downregulate the expression of N-cadherin,snail1,Wnt3 a,p-beta-catenin,p-LRP6 and Bcl-2,and upregulate the expression of E-cadherin and Bax,it could increase the activity of caspase-3,caspase-8,caspase-9 and induce apoptosis as well.	Curcumin	9-17	LDL receptor related protein 6	Homo sapiens	147-151
31145652-7	2019	Then, we identified that curcumin upregulated the expression of self-renewal genes, Notch1 and Hes1, and augmentation of CDK4, Cyclin D1, NICD, and Hes1 protein.	Curcumin	25-33	cyclin D1	Mus musculus	127-136
30875026-11	2019	A curcumin nanoformulation sized 77 nm and containing of 3% ethanol was more effective in increasing beta1-integrin gene over-expression, anti-apoptosis of fibroblast cells (Bcl2/Bax ratio), and in decreasing Bax and NFkappaB gene expression than that with a particle size of 50 nm.	Curcumin	2-10	integrin subunit beta 1	Homo sapiens	101-115
30946834-0	2019	Curcumin analogues attenuate Abeta25-35-induced oxidative stress in PC12 cells via Keap1/Nrf2/HO-1 signaling pathways.	Curcumin	0-8	Kelch-like ECH-associated protein 1	Rattus norvegicus	83-88
30946834-0	2019	Curcumin analogues attenuate Abeta25-35-induced oxidative stress in PC12 cells via Keap1/Nrf2/HO-1 signaling pathways.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	94-98
31223428-0	2019	Curcumin Inhibits the PERK-eIF2alpha-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model.	Curcumin	0-8	eukaryotic translation initiation factor 2A	Rattus norvegicus	27-36
31223428-5	2019	Curcumin inhibited the expression of cleaved caspase3, cleaved poly (ADP-ribose) polymerase (PARP), C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the chondroprotective protein Bcl2 in TBHP-treated chondrocytes.	Curcumin	0-8	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	137-164
31223428-5	2019	Curcumin inhibited the expression of cleaved caspase3, cleaved poly (ADP-ribose) polymerase (PARP), C/EBP homologous protein (CHOP), and glucose-regulated protein78 (GRP78) and upregulated the chondroprotective protein Bcl2 in TBHP-treated chondrocytes.	Curcumin	0-8	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	166-171
31223428-6	2019	In addition, curcumin promoted the expression of silent information regulator factor 2-related enzyme 1 (SIRT1) and suppressed the expression of activating transcription factor 4 (ATF4), the ratio of p-PERK/PERK, p-eIF2alpha/eIF2alpha.	Curcumin	13-21	eukaryotic translation initiation factor 2A	Rattus norvegicus	215-224
31223428-6	2019	In addition, curcumin promoted the expression of silent information regulator factor 2-related enzyme 1 (SIRT1) and suppressed the expression of activating transcription factor 4 (ATF4), the ratio of p-PERK/PERK, p-eIF2alpha/eIF2alpha.	Curcumin	13-21	eukaryotic translation initiation factor 2A	Rattus norvegicus	225-234
31223428-9	2019	Taken together, our present findings firstly indicate that curcumin could inhibit the PERK-eIF2alpha-CHOP axis of the ER stress response through the activation of SIRT1 in tert-Butyl hydroperoxide- (TBHP-) treated rat chondrocytes and ameliorated osteoarthritis development in vivo.	Curcumin	59-67	eukaryotic translation initiation factor 2A	Rattus norvegicus	91-100
30392062-0	2019	Curcumin ameliorates PRMT5-MEP50 arginine methyltransferase expression by decreasing the Sp1 and NF-YA transcription factors in the A549 and MCF-7 cells.	Curcumin	0-8	nuclear transcription factor Y subunit alpha	Homo sapiens	97-102
30392062-6	2019	We also found that curcumin significantly reduced the level and enrichment of the transcription factors Sp1 and NF-YA which shares their binding sites within the GC-rich region of the PRMT5 proximal promoter.	Curcumin	19-27	nuclear transcription factor Y subunit alpha	Homo sapiens	112-117
30392062-7	2019	Furthermore, the involvement of both PKC-p38-ERK-cFos and AKT-mTOR signalling was observed in reducing the Sp1 and NF-YA expression by curcumin.	Curcumin	135-143	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-53
30392062-7	2019	Furthermore, the involvement of both PKC-p38-ERK-cFos and AKT-mTOR signalling was observed in reducing the Sp1 and NF-YA expression by curcumin.	Curcumin	135-143	nuclear transcription factor Y subunit alpha	Homo sapiens	115-120
25241044-0	2014	Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	30-35
25241044-4	2014	The purpose of our study was to investigate the molecular mechanisms by which curcumin affects MMP-9, MMP13 and EMMPRIN in PMA (phorbol 12-myristate 13-acetate) induced macrophages.	Curcumin	78-86	matrix metallopeptidase 9	Homo sapiens	95-100
25241044-6	2014	In the present study, the exposure to curcumin resulted in attenuated JNK, p38, and ERK activation and decreased expression of MMP-9, MMP-13 and EMMPRIN in PMA induced macrophages.	Curcumin	38-46	matrix metallopeptidase 9	Homo sapiens	127-132
25241044-8	2014	Furthermore, curcumin reversed PMA stimulated PKC activation and suppressed the chronic activation of AMPK, which in turn reduced the expression of MMP-9, MMP-13 and EMMPRIN.	Curcumin	13-21	matrix metallopeptidase 9	Homo sapiens	148-153
25241044-9	2014	Therefore, it is suggested that curcumin by inhibiting AMPK-MAPK (mitogen activated protein kinase) and PKC pathway may led to down-regulated EMMPRIN, MMP-9 and MMP-13 expression in PMA-induced THP-1 cells.	Curcumin	32-40	matrix metallopeptidase 9	Homo sapiens	151-156
25400722-8	2014	Curcumin also inhibited SCC-25 cells invasion and downregulated MMP-2, MMP-9, uPA and uPAR expression.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	71-76
30843426-3	2019	MATERIALS &amp; METHODS: The effects of various concentrations of curcumin on the NSCLC cell lines A549 and SPC-A1 were evaluated by MTT assay, colony-forming assay and flow cytometry.	Curcumin	66-74	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	108-114
30968152-13	2019	Treatment with curcumin also increased the expression of P4HB and PRDX4 in the tissue of the small intestine.	Curcumin	15-23	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	57-61
25088002-8	2014	Pretreatment with curcumin, an inhibitor of JAK2 and p300, blocked Ang II-induced effects.	Curcumin	18-26	Janus kinase 2	Rattus norvegicus	44-48
26515751-8	2016	In cultured primary osteoblasts, pretreatment with curcumin concentration-dependently decreased the number of Dex-induced apoptotic osteoblasts by down-regulating the ratio of Bax/Bcl-2 as well as the levels of cleaved caspase-3 and cleaved poly ADP-ribose polymerase (PARP).	Curcumin	51-59	poly (ADP-ribose) polymerase 1	Rattus norvegicus	269-273
26677102-12	2016	In addition, curcumin upregulated the mRNA expression levels of transcription factors that favor osteoblast differentiation and increased the ratio of OPG to RANKL.	Curcumin	13-21	TNF receptor superfamily member 11B	Rattus norvegicus	151-154
24998635-7	2014	We found that curcumin decreased the release of IL-6 and reduced MMP-9 enzyme activity.	Curcumin	14-22	matrix metallopeptidase 9	Homo sapiens	65-70
30968152-16	2019	Furthermore, curcumin abolished NF-kappaB signal transduction and protected the cells from CPT-11-induced apoptosis by upregulating the expression of molecular chaperones, such as GRP78, P4HB and PRDX4, and suppressing the levels of the apoptosis-related proteins, CHOP and cleaved caspase-3.	Curcumin	13-21	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	180-185
26677102-15	2016	Immunofluorescence staining revealed that curcumin restored the intranuclear staining of beta-catenin in the DXM-stimulated osteoblasts.	Curcumin	42-50	catenin beta 1	Rattus norvegicus	89-101
30968152-16	2019	Furthermore, curcumin abolished NF-kappaB signal transduction and protected the cells from CPT-11-induced apoptosis by upregulating the expression of molecular chaperones, such as GRP78, P4HB and PRDX4, and suppressing the levels of the apoptosis-related proteins, CHOP and cleaved caspase-3.	Curcumin	13-21	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	187-191
26773315-5	2016	Curcumin (100 mg/kg) attenuated PCM-induced liver histological damage (damaged hepatocytes from 28.3 +- 7.7 to 8.3 +- 0.7%) and increment in plasma ALT (from 2300 +- 150 to 690 +- 28 U/l) and AST (from 1603 +- 43 to 379 +- 22 U/l) activity.	Curcumin	0-8	glutamic pyruvic transaminase, soluble	Mus musculus	148-151
30849141-0	2019	Half-curcumin analogues as PET imaging probes for amyloid beta species.	Curcumin	5-13	thyroid stimulating hormone receptor	Mus musculus	27-30
26773315-5	2016	Curcumin (100 mg/kg) attenuated PCM-induced liver histological damage (damaged hepatocytes from 28.3 +- 7.7 to 8.3 +- 0.7%) and increment in plasma ALT (from 2300 +- 150 to 690 +- 28 U/l) and AST (from 1603 +- 43 to 379 +- 22 U/l) activity.	Curcumin	0-8	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	192-195
31025030-11	2019	Moreover, GLUT3 and GLUT4 levels were significantly increased in Curcumin-treated AD rats.	Curcumin	65-73	solute carrier family 2 member 3	Rattus norvegicus	10-15
26691217-9	2016	Induction of CUGBP2 expression by curcumin resulted in the downregulation of HO-1 and COX-2 and strongly sensitized tumor cells to GEM treatment.	Curcumin	34-42	heme oxygenase 1	Homo sapiens	77-81
26713546-7	2016	In addition, inhibitor kappaB alpha (IkappaBalpha) degradation was prevented by curcumin supplementation.	Curcumin	80-88	NFKB inhibitor alpha	Rattus norvegicus	37-49
26278546-3	2016	These cells were then exposed to different concentration of cytarabine and curcumin to find out IC50 values and also its effect on MDR genes like MDR1, BCRP, LRP and FLT3 by RT-PCR method.	Curcumin	75-83	BCR pseudogene 1	Homo sapiens	152-156
27644631-4	2016	It was found that curcumin induced a dose dependent decrease in cell viability because of apoptosis induction as visualized by annexin V-FITC/ PI staining.	Curcumin	18-26	annexin A5	Homo sapiens	127-136
26531053-0	2016	Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines.	Curcumin	0-8	H3 histone pseudogene 16	Homo sapiens	88-91
26729105-6	2015	Furthermore, curcumin treatment decreased glial scar formation by decreasing the levels of MIP1alpha, IL-2, and RANTES production and by decreasing NF-kappaB activity.	Curcumin	13-21	interleukin 2	Rattus norvegicus	102-106
26656720-8	2015	Curcumin inhibited the migratory and invasive ability of A549 cells via the inhibition of adiponectin expression by blocking the adiponectin receptor 1.	Curcumin	0-8	adiponectin receptor 1	Homo sapiens	129-151
26734640-0	2015	The critical roles of miR-21 in anti-cancer effects of curcumin.	Curcumin	55-63	microRNA 21	Homo sapiens	22-28
26734640-4	2015	In this review, we focus on the roles of microRNA-21 (miR-21) in the anti-cancer effects of curcumin and regulatory mechanisms for the effects of curcumin on miR-21.	Curcumin	92-100	microRNA 21	Homo sapiens	41-52
26734640-4	2015	In this review, we focus on the roles of microRNA-21 (miR-21) in the anti-cancer effects of curcumin and regulatory mechanisms for the effects of curcumin on miR-21.	Curcumin	92-100	microRNA 21	Homo sapiens	54-60
26734640-4	2015	In this review, we focus on the roles of microRNA-21 (miR-21) in the anti-cancer effects of curcumin and regulatory mechanisms for the effects of curcumin on miR-21.	Curcumin	146-154	microRNA 21	Homo sapiens	158-164
26734640-5	2015	MiR-21 mediates various effects of curcumin on cancer cells including proliferation, apoptosis, metastasis and anti-cancer drug resistance.	Curcumin	35-43	microRNA 21	Homo sapiens	0-6
26734640-7	2015	Curcumin decreases miR-21 levels through both increasing miR-21 exosome exclusion from the cells and inhibiting the transcription of the miR-21 gene in the cells by binding to its promoter.	Curcumin	0-8	microRNA 21	Homo sapiens	19-25
26734640-7	2015	Curcumin decreases miR-21 levels through both increasing miR-21 exosome exclusion from the cells and inhibiting the transcription of the miR-21 gene in the cells by binding to its promoter.	Curcumin	0-8	microRNA 21	Homo sapiens	57-63
26734640-7	2015	Curcumin decreases miR-21 levels through both increasing miR-21 exosome exclusion from the cells and inhibiting the transcription of the miR-21 gene in the cells by binding to its promoter.	Curcumin	0-8	microRNA 21	Homo sapiens	57-63
27259310-5	2015	The cells treated with curcumin increasingly went into cell cycle arrest, which was likely mediated by diminished expression of cyclin B1, as seen in curcumin-treated cells.	Curcumin	23-31	cyclin B1	Homo sapiens	128-137
27259310-5	2015	The cells treated with curcumin increasingly went into cell cycle arrest, which was likely mediated by diminished expression of cyclin B1, as seen in curcumin-treated cells.	Curcumin	150-158	cyclin B1	Homo sapiens	128-137
26498137-0	2015	Curcumin-induced downregulation of Axl receptor tyrosine kinase inhibits cell proliferation and circumvents chemoresistance in non-small lung cancer cells.	Curcumin	0-8	AXL receptor tyrosine kinase	Homo sapiens	35-38
26498137-0	2015	Curcumin-induced downregulation of Axl receptor tyrosine kinase inhibits cell proliferation and circumvents chemoresistance in non-small lung cancer cells.	Curcumin	0-8	ret proto-oncogene	Homo sapiens	39-63
26498137-2	2015	In the present study, we demonstrated the effect of curcumin, a phytochemical of the plant Curcuma longa, on expression and activation of Axl receptor tyrosine kinase (RTK) which plays an important role in cell survival, proliferation and anti-apoptosis.	Curcumin	52-60	AXL receptor tyrosine kinase	Homo sapiens	138-141
26498137-2	2015	In the present study, we demonstrated the effect of curcumin, a phytochemical of the plant Curcuma longa, on expression and activation of Axl receptor tyrosine kinase (RTK) which plays an important role in cell survival, proliferation and anti-apoptosis.	Curcumin	52-60	ret proto-oncogene	Homo sapiens	142-166
26498137-2	2015	In the present study, we demonstrated the effect of curcumin, a phytochemical of the plant Curcuma longa, on expression and activation of Axl receptor tyrosine kinase (RTK) which plays an important role in cell survival, proliferation and anti-apoptosis.	Curcumin	52-60	ret proto-oncogene	Homo sapiens	168-171
26498137-3	2015	Curcumin treatment of non-small cell lung cancer (NSCLC) A549 and H460 cells, was found to decrease Axl protein as well as mRNA levels in a dose- and time-dependent manner.	Curcumin	0-8	AXL receptor tyrosine kinase	Homo sapiens	100-103
26498137-4	2015	Axl promoter activity was also reduced by curcumin, indicating that curcumin downregulates Axl expression at the transcriptional level.	Curcumin	42-50	AXL receptor tyrosine kinase	Homo sapiens	0-3
26498137-4	2015	Axl promoter activity was also reduced by curcumin, indicating that curcumin downregulates Axl expression at the transcriptional level.	Curcumin	42-50	AXL receptor tyrosine kinase	Homo sapiens	91-94
26498137-4	2015	Axl promoter activity was also reduced by curcumin, indicating that curcumin downregulates Axl expression at the transcriptional level.	Curcumin	68-76	AXL receptor tyrosine kinase	Homo sapiens	0-3
26330141-0	2015	Curcumin attenuates palmitate-induced apoptosis in MIN6 pancreatic beta-cells through PI3K/Akt/FoxO1 and mitochondrial survival pathways.	Curcumin	0-8	forkhead box O1	Mus musculus	95-100
26330141-9	2015	Moreover, curcumin could promote rapid phosphorylation of Akt and nuclear exclusion of FoxO1 in MIN6 cells under lipotoxic condition.	Curcumin	10-18	forkhead box O1	Mus musculus	87-92
26330141-11	2015	These findings suggested that curcumin protected MIN6 pancreatic beta-Cells against apoptosis through activation of Akt, inhibition of nuclear translocation of FoxO1 and mitochondrial survival pathway.	Curcumin	30-38	forkhead box O1	Mus musculus	160-165
25716014-8	2015	mRNA and protein expression of caspase-3 and caspase-9 and proapoptotic genes was increased in cells treated with a combination of curcumin and carboplatin, whereas expression of the antiapoptotic Bcl-2 gene was suppressed.	Curcumin	131-139	caspase 9	Homo sapiens	45-54
26300394-9	2015	Treatment of SCI rats with curcumin enhanced mRNA levels of Wnt3a, Lrp5, and ctnnb1 and upregulated protein expression of beta-catenin in distal femurs.	Curcumin	27-35	catenin beta 1	Rattus norvegicus	122-134
26300394-10	2015	In conclusions, treatment with curcumin abated oxidative stress, activated VDR, and enhanced Wnt/beta-catenin pathway, which might explain its beneficial effect against sublesional bone loss following SCI in rats, at least in part.	Curcumin	31-39	vitamin D receptor	Rattus norvegicus	75-78
26300394-10	2015	In conclusions, treatment with curcumin abated oxidative stress, activated VDR, and enhanced Wnt/beta-catenin pathway, which might explain its beneficial effect against sublesional bone loss following SCI in rats, at least in part.	Curcumin	31-39	Wnt family member 2	Rattus norvegicus	93-96
26300394-10	2015	In conclusions, treatment with curcumin abated oxidative stress, activated VDR, and enhanced Wnt/beta-catenin pathway, which might explain its beneficial effect against sublesional bone loss following SCI in rats, at least in part.	Curcumin	31-39	catenin beta 1	Rattus norvegicus	97-109
25331984-6	2015	METHODS: Using a transgenic mouse model of gastric cancer in which beta-catenin, cyclooxygenase 2, and microsomal prostaglandin E synthase 1 activation is induced, we examined a curcumin analog with the most enhanced potential for treating gastric cancer through oral administration.	Curcumin	178-186	prostaglandin E synthase	Mus musculus	103-140
26239619-2	2015	The present study was undertaken to determine whether the cytotoxicity of curcumin (diferuloylmethane), a natural polyphenolic compound isolated from turmeric (Curcuma longa Linn), in glioblastoma cells is mediated through upregulation of miR-146a.	Curcumin	84-101	microRNA 146a	Homo sapiens	239-247
26239619-5	2015	Curcumin exposure led to upregulation of miR-146a in U-87 MG cells.	Curcumin	0-8	microRNA 146a	Homo sapiens	41-49
26239619-7	2015	Notably, curcumin-mediated enhancement of TMZ-induced apoptosis was blocked by depletion of miR-146a.	Curcumin	9-17	microRNA 146a	Homo sapiens	92-100
26239619-10	2015	To the best of our knowledge, the present study provides the first evidence that upregulation of miR-146a and inactivation of NF-kappaB signaling mediates the sensitization of human glioblastoma cells to TMZ-induced apoptosis by curcumin.	Curcumin	229-237	microRNA 146a	Homo sapiens	97-105
26677679-9	2015	mRNA expressions of PDGF-beta was lower in TGF-beta2 (10 ng/mL) plus curcumin groups than in the TGF-beta2 group (P &lt; 0.05).	Curcumin	69-77	platelet derived growth factor, B polypeptide	Mus musculus	20-29
26677679-10	2015	Besides, PDGF-beta mRNA expressions were lower in the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group than in the TGF-beta2 (10 ng/mL) plus curcumin 5 mumol/L group and the TGF-beta2 (10 ng/mL) plus curcumin 25 mumol/L group (P &lt; 0.05).	Curcumin	80-88	platelet derived growth factor, B polypeptide	Mus musculus	9-18
26677679-10	2015	Besides, PDGF-beta mRNA expressions were lower in the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group than in the TGF-beta2 (10 ng/mL) plus curcumin 5 mumol/L group and the TGF-beta2 (10 ng/mL) plus curcumin 25 mumol/L group (P &lt; 0.05).	Curcumin	144-152	platelet derived growth factor, B polypeptide	Mus musculus	9-18
26677679-10	2015	Besides, PDGF-beta mRNA expressions were lower in the TGF-beta2 (10 ng/mL) plus curcumin 50 mumol/L group than in the TGF-beta2 (10 ng/mL) plus curcumin 5 mumol/L group and the TGF-beta2 (10 ng/mL) plus curcumin 25 mumol/L group (P &lt; 0.05).	Curcumin	144-152	platelet derived growth factor, B polypeptide	Mus musculus	9-18
26677679-15	2015	Therefore, curcumin might inhibit the occurrence and developing of lung fibrosis through blocking PPAR-gamma/PDGF-beta signaling pathway.	Curcumin	11-19	platelet derived growth factor, B polypeptide	Mus musculus	109-118
26451117-9	2015	RESULTS: The levels of HIF-1alpha and VEGF, and MVD in tumors of liposomal curcumin TAE-treated group were significantly decreased compared to the TAE-treated group (P&lt;0.05).	Curcumin	75-83	hypoxia-inducible factor 1-alpha	Oryctolagus cuniculus	23-33
26451117-13	2015	CONCLUSION: Liposomal curcumin downregulates HIF-1alpha protein levels and inhibits hypoxia-induced angiogenesis after embolization in VX2 rabbit liver tumors.	Curcumin	22-30	hypoxia-inducible factor 1-alpha	Oryctolagus cuniculus	45-55
26116834-0	2015	Curcumin inhibits in vitro and in vivo chronic myelogenous leukemia cells growth: a possible role for exosomal disposal of miR-21.	Curcumin	0-8	microRNA 21	Homo sapiens	123-129
26116834-3	2015	The addition of Curcumin, to Chronic Myelogenous Leukemia (CML) cells, caused a dose-dependent increase of PTEN, target of miR-21.	Curcumin	16-24	phosphatase and tensin homolog	Homo sapiens	107-111
26116834-3	2015	The addition of Curcumin, to Chronic Myelogenous Leukemia (CML) cells, caused a dose-dependent increase of PTEN, target of miR-21.	Curcumin	16-24	microRNA 21	Homo sapiens	123-129
23821378-0	2014	Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase.	Curcumin	0-8	fatty acid synthase	Homo sapiens	57-76
26116834-7	2015	To elucidate if Curcumin caused a decrease of miR-21 in CML cells and its packaging in exosomes, we analyzed miR-21 content in K562 and LAMA84 cells and exosomes, after treatment with Curcumin.	Curcumin	16-24	microRNA 21	Homo sapiens	46-52
23821378-3	2014	In the present study, we investigated the potential use of curcumin as a kind of FAS inhibitor for chemoprevention of liver cancer.	Curcumin	59-67	fatty acid synthase	Homo sapiens	81-84
23821378-7	2014	Further studies reviewed that siRNA of FAS showed similar results as curcumin.	Curcumin	69-77	fatty acid synthase	Homo sapiens	39-42
24835302-8	2014	Western blot analysis showed that the expressions of IkB, nuclear p65, cyclooxygenase 2 (COX-2) and p-ERK1/2 were down-regulated by curcumin in vitro.	Curcumin	132-140	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta	Mus musculus	53-56
30711953-3	2019	The aim of this study was to investigate the effect of curcumin in comparison to cinnamaldehyde on the enzymatic activity of PTP1B and the viability of MCF-7 cancer cells.	Curcumin	55-63	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	125-130
30711953-6	2019	RESULTS: Curcumin and cinnamaldehyde decreased the activity of PTP1B, and had inhibitory effects on the viability of MCF-7 cancer cells.	Curcumin	9-17	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	63-68
26116834-11	2015	Taken together, our results suggested that a selective packaging of miR-21 in exosomes may contribute to the antileukemic effect of Curcumin in CML.	Curcumin	132-140	microRNA 21	Homo sapiens	68-74
25998196-15	2015	Gene expressions of muscle-specific ubiquitin E3 ligase atrogin-1/MAFbx and MuRF1 were increased in DM and inhibited in DM+Curcumin mice.	Curcumin	123-131	F-box protein 32	Mus musculus	66-71
30467667-11	2019	Moreover, 48 h curcumin treatment prevented the autocrine GH-mediated miR-182-96-183 cluster expression stimulation in T47D cells.	Curcumin	15-23	microRNA 182	Homo sapiens	70-77
30467667-12	2019	In consequence, curcumin treatment for 48 h, prevented autocrine GH-triggered invasion-metastasis, EMT activation through inhibiting NF-kappaB signaling and miR-182-96-183 cluster expression and induced apoptotic cell death by modulating Bcl-2 family members in T47D breast cancer cells.	Curcumin	16-24	microRNA 182	Homo sapiens	157-164
24628444-8	2014	Curcumin modulates the T lymphocyte response impairing proliferation and interferon (IFN)-gamma production through modulation of T-box expressed in T cells (T-bet), a key transcription factor for proinflammatory T helper type 1 (Th1) lymphocyte differentiation, both at the transcriptional and translational levels.	Curcumin	0-8	T-box 21	Mus musculus	157-162
24944632-6	2014	In conclusion, these results indicated that co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression of ApoAI, CYP7A1, LCAT and LDLR, providing a promising combination for the treatment of HLP.	Curcumin	65-73	lecithin cholesterol acyltransferase	Rattus norvegicus	209-213
24944632-6	2014	In conclusion, these results indicated that co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression of ApoAI, CYP7A1, LCAT and LDLR, providing a promising combination for the treatment of HLP.	Curcumin	135-143	lecithin cholesterol acyltransferase	Rattus norvegicus	209-213
24566270-8	2014	FROM THE CLINICAL EDITOR: In this novel study, lipid nanoparticles encapsulating curcumin were able to prevent metastasis formation and limited the progression of the disease by modulating vascular inflammation and impairing the circulating tumor cells" arrest as a result of down-regulation of ICAM1 and MUC1 in a highly metastatic breast cancer cell line model.	Curcumin	81-89	intercellular adhesion molecule 1	Homo sapiens	295-300
30800669-7	2019	Importantly, curcumin activated neurogenesis of NTERA2 cells via the activation of autophagy, since autophagy-related genes, such as LC3, LAMP1, and ATG5, were upregulated along with the expression of neural genes.	Curcumin	13-21	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	133-136
24777807-8	2014	Accordingly, the index of mitochondrial biogenesis including nuclear respiratory factor-1, mitochondrial transcription factor A and mitochondrial number significantly down-regulated in I/R rats were reversed by curcumin pretreatment in a dose-dependent manner, and the mitochondrial uncoupling protein 2 presented the similar change.	Curcumin	211-219	uncoupling protein 2	Rattus norvegicus	269-303
26299580-5	2015	Mechanistic studies showed that anticancer activity of curcumin is associated with decrease in migration of HNSCC and associated angiogenesis through activating of intrinsic apoptotic pathway (caspase-9) and extrinsic apoptotic pathway (caspase-8).	Curcumin	55-63	caspase 9	Homo sapiens	193-202
24780320-8	2014	KEY FINDINGS: Exosomes derived from curcumin-treated (primed) cells (CUR-EXO) alleviated oxidative stress, tight junctions (ZO-1, claudin-5, occludin), adherent junction (VE-cadherin) proteins and EC layer permeability induced during EC damage due to high homocysteine levels (hyperhomocysteinemia).	Curcumin	36-44	claudin 5	Mus musculus	130-139
26299580-6	2015	Our data demonstrating that anticancer activity of curcumin is linked to the activation of the ATM/CHK2 pathway and the inhibition of nuclear factor-kappaB.	Curcumin	51-59	ATM serine/threonine kinase	Homo sapiens	95-98
30788007-0	2019	Therapeutic ultrasound potentiates the anti-nociceptive and anti-inflammatory effects of curcumin to postoperative pain via Sirt1/NF-kappaB signaling pathway [Retraction].	Curcumin	89-97	sirtuin 1	Homo sapiens	124-129
26299580-7	2015	Finally, increasing SIRT1 through small molecule activator curcumin has shown beneficial effects in xenograft mouse model, indicating that SIRT1 may represent an attractive therapeutic target.	Curcumin	59-67	sirtuin 1	Mus musculus	20-25
26299580-7	2015	Finally, increasing SIRT1 through small molecule activator curcumin has shown beneficial effects in xenograft mouse model, indicating that SIRT1 may represent an attractive therapeutic target.	Curcumin	59-67	sirtuin 1	Mus musculus	139-144
24982601-2	2014	Curcumin, a powerful promoter of anti-oxidant response, is one of the best-investigated natural products, and is now commercially available as a lecithin delivery system (Meriva , Indena SpA, Milan) with improved bio-availability.	Curcumin	0-8	surfactant protein A2	Homo sapiens	187-190
25893520-0	2015	Curcumin/melatonin hybrid 5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide ameliorates AD-like pathology in the APP/PS1 mouse model.	Curcumin	0-8	presenilin 1	Mus musculus	151-154
24608370-0	2014	Curcuma longa (curcumin) decreases in vivo cisplatin-induced ototoxicity through heme oxygenase-1 induction.	Curcumin	15-23	heme oxygenase 1	Rattus norvegicus	81-97
24608370-1	2014	HYPOTHESIS: To investigate whether curcumin may have in vivo protective effects against cisplatin ototoxicity by its direct scavenger activity and/or by curcumin-mediated upregulation of HO-1.	Curcumin	153-161	heme oxygenase 1	Rattus norvegicus	187-191
24608370-10	2014	RESULTS: Curcumin treatment attenuated hearing loss induced by cisplatin, increased OHC survival, decreased 4-HNE expression, and increased HO-1 expression.	Curcumin	9-17	heme oxygenase 1	Rattus norvegicus	140-144
30788258-0	2019	Preparation and characterization of biocomposite films of carrageenan/locust bean gum/montmorrillonite for transdermal delivery of curcumin.	Curcumin	131-139	brain expressed associated with NEDD4 1	Homo sapiens	77-81
30788258-4	2019	Curcumin was incorporated into biocomposite films of carrageenan (kappaC)/locust bean gum (LBG)/ montmorillonite (MMT) prepared by a solvent casting method.	Curcumin	0-8	brain expressed associated with NEDD4 1	Homo sapiens	81-85
30551377-0	2019	Curcumin pretreatment protects against hypoxia/reoxgenation injury via improvement of mitochondrial function, destabilization of HIF-1alpha and activation of Epac1-Akt pathway in rat bone marrow mesenchymal stem cells.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	129-139
30551377-7	2019	In addition, curcumin pretreatment notably induced HIF-1alpha destabilization, Epac1 and Akt activation, and Erk1/2 and p38 deactivation.	Curcumin	13-21	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	51-61
30551377-9	2019	Taken together, these results demonstrated that curcumin pretreatment conferred BMSCs the ability to survive from H/R injury, which might attribute to its protection on mitochondrial function, destabilization of HIF-1alpha and activation of Epac1-Akt signaling pathway.	Curcumin	48-56	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	212-222
30367912-0	2019	Curcumin restores hepatic epigenetic changes in propylthiouracil(PTU)Induced hypothyroid male rats: A study on DNMTs, MBDs, GADD45a, C/EBP-beta and PCNA.	Curcumin	0-8	proliferating cell nuclear antigen	Rattus norvegicus	148-152
30762443-10	2019	The expression of CD31 was reduced while NG2 was increased significantly by the combination of APS and curcumin.	Curcumin	103-111	chondroitin sulfate proteoglycan 4	Mus musculus	41-44
24508537-6	2014	The results showed that curcumin attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in a dose-dependent manner.	Curcumin	24-32	myeloperoxidase	Mus musculus	100-115
24508537-6	2014	The results showed that curcumin attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in a dose-dependent manner.	Curcumin	24-32	myeloperoxidase	Mus musculus	117-120
24484937-2	2014	We have previously reported that the chemopreventive polyphenol Curcumin inhibits the expression of the proinflammatory cytokines CXCL1 and -2 leading to diminished formation of breast and prostate cancer metastases.	Curcumin	64-72	C-X-C motif chemokine ligand 1	Homo sapiens	130-142
26711214-0	2015	[Relationship of GSTP1 lower expression and multidrug resistance reversing of curcumin on human colon carcinoma cells].	Curcumin	78-86	glutathione S-transferase pi 1	Homo sapiens	17-22
24484937-9	2014	Finally, we demonstrated that Curcumin up-regulates miR181b and down-regulates CXCL1 and -2 in cells isolated from several primary human breast cancers.	Curcumin	30-38	C-X-C motif chemokine ligand 1	Homo sapiens	79-91
25169090-12	2014	CONCLUSION: Oxidative stress plays an important role in paraquat-induced acute liver damage in rats, and curcumin can exert a hepatoprotective effect against oxidative stress by increasing the expression of Nrf2 and the activities of HO-1, NQO-1, SOD, and CAT and reducing the content of MDA.	Curcumin	105-113	heme oxygenase 1	Rattus norvegicus	234-238
24705375-10	2014	However, the enzyme activities of caspase 3 and caspase 9 showed a significant increase upon treatment with curcumin and resveratrol.	Curcumin	108-116	caspase 3	Mus musculus	34-43
24313805-0	2014	Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	0-8	Phosphatidylinositol 3-kinase age-1	Caenorhabditis elegans	88-93
24313805-0	2014	Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	0-8	3-phosphoinositide-dependent protein kinase 1	Caenorhabditis elegans	102-107
24313805-6	2014	Lastly, our findings from the mechanistic study in this investigation suggest that the antioxidative effect of curcumin is mediated via regulation of age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	111-119	Phosphatidylinositol 3-kinase age-1	Caenorhabditis elegans	150-155
24313805-6	2014	Lastly, our findings from the mechanistic study in this investigation suggest that the antioxidative effect of curcumin is mediated via regulation of age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1.	Curcumin	111-119	3-phosphoinositide-dependent protein kinase 1	Caenorhabditis elegans	164-169
30145810-0	2019	Curcumin-mediated demethylation of the proximal promoter CpG island enhances the KLF4 recruitment that leads to increased expression of p21Cip1 in vitro.	Curcumin	0-8	Kruppel like factor 4	Homo sapiens	81-85
30145810-7	2019	The curcumin significantly raised the level KLF4 and enhanced the p21 promoter occupancy by KLF4.	Curcumin	4-12	Kruppel like factor 4	Homo sapiens	44-48
30145810-7	2019	The curcumin significantly raised the level KLF4 and enhanced the p21 promoter occupancy by KLF4.	Curcumin	4-12	Kruppel like factor 4	Homo sapiens	92-96
30145810-8	2019	From our results we hypothesize that curcumin-mediated demethylation of the p21 proximal promoter and increased KLF4 expression as well as its binding to its proximal promoter could serve as a mechanism that could be hypothesized to cause upregulation of p21 in presence of curcumin and thus its therapeutic implications could further be investigated.	Curcumin	37-45	Kruppel like factor 4	Homo sapiens	112-116
30145810-8	2019	From our results we hypothesize that curcumin-mediated demethylation of the p21 proximal promoter and increased KLF4 expression as well as its binding to its proximal promoter could serve as a mechanism that could be hypothesized to cause upregulation of p21 in presence of curcumin and thus its therapeutic implications could further be investigated.	Curcumin	274-282	Kruppel like factor 4	Homo sapiens	112-116
24606473-3	2014	It was further intended to investigate whether curcumin could sensitize the cells towards cisplatin induced cell killing by modulation of multi drug resistant proteins like MRP1 and Pgp1.	Curcumin	47-55	CD44 molecule (Indian blood group)	Homo sapiens	182-186
24606473-6	2014	Cisplatin resistance in SiHaR due to over-expression of MRP1 and Pgp1 was overcome by curcumin.	Curcumin	86-94	CD44 molecule (Indian blood group)	Homo sapiens	65-69
30655747-0	2019	Apoptosis of mouse myeloma cells induced by curcumin via the Notch3-p53 signaling axis.	Curcumin	44-52	notch 3	Mus musculus	61-67
26711214-9	2015	RT-PCR and Western blotting results showed that the expressions of GSTP1 mRNA (0.49+-0.09) and protein (0.29+-0.07) in curcumin-treated group were significantly lower than in control group (GSTP1 mRNA 1.19+-0.21 and protein 0.70+-0.13, both P&lt;0.05), indicating that curcumin down regulated these expressions.	Curcumin	119-127	glutathione S-transferase pi 1	Homo sapiens	67-72
30655747-4	2019	The present study was designed to investigate the antitumor effect of curcumin by the Notch3-p53 axis in mouse myeloma P3X63Ag8 cells.	Curcumin	70-78	notch 3	Mus musculus	86-92
30655747-11	2019	Curcumin inhibited the expression of Notch3, while the middle- and high-dose groups promoted p53.	Curcumin	0-8	notch 3	Mus musculus	37-43
30655747-14	2019	These data indicated that curcumin exhibited antitumor effects in mouse myeloma cells with induction of apoptosis by affecting the Notch3-p53 signaling axis.	Curcumin	26-34	notch 3	Mus musculus	131-137
24606473-9	2014	Suppression of MRP1 and Pgp1 by curcumin resulted in sensitization of cervical cancer cells, lowering the chemotherapeutic dose of the drug cisplatin.	Curcumin	32-40	CD44 molecule (Indian blood group)	Homo sapiens	24-28
24606484-0	2014	Curcumin inhibits expression of inhibitor of DNA binding 1 in PC3 cells and xenografts.	Curcumin	0-8	inhibitor of DNA binding 1, HLH protein	Mus musculus	32-58
24606484-0	2014	Curcumin inhibits expression of inhibitor of DNA binding 1 in PC3 cells and xenografts.	Curcumin	0-8	proprotein convertase subtilisin/kexin type 1	Mus musculus	62-65
24606484-4	2014	Here we investigated whether Id1 might be involved in the anti-cancer effects of curcumin in vivo and in vitro.	Curcumin	81-89	inhibitor of DNA binding 1, HLH protein	Mus musculus	29-32
24606484-5	2014	We firstly confirmed that curcumin inhibited cell viability in a dose-dependent fashion, and induced apoptosis in PC3 cells, associated with significant decrease in the mRNA and protein expression of Id1.	Curcumin	26-34	proprotein convertase subtilisin/kexin type 1	Mus musculus	114-117
24606484-5	2014	We firstly confirmed that curcumin inhibited cell viability in a dose-dependent fashion, and induced apoptosis in PC3 cells, associated with significant decrease in the mRNA and protein expression of Id1.	Curcumin	26-34	inhibitor of DNA binding 1, HLH protein	Mus musculus	200-203
24606484-6	2014	Similar effects of curcumin were observed in tumors of the PC3 xenografted mouse model with introperitoneal injection of curcumin once a day for one month.	Curcumin	19-27	proprotein convertase subtilisin/kexin type 1	Mus musculus	59-62
24606484-10	2014	Curcumin may be used as an Id1 inhibitor to modulate Id1 expression.	Curcumin	0-8	inhibitor of DNA binding 1, HLH protein	Mus musculus	27-30
24606484-10	2014	Curcumin may be used as an Id1 inhibitor to modulate Id1 expression.	Curcumin	0-8	inhibitor of DNA binding 1, HLH protein	Mus musculus	53-56
30567342-8	2018	Moreover, our inverse docking results showed that curcumin potentially binds also to the proteins cAMP-specific 3",5"-cyclic phosphodiesterase 4D and 17-beta-hydroxysteroid dehydrogenase type 10, which provides a new explanation for its efficiency in the treatment of Alzheimer"s disease.	Curcumin	50-58	phosphodiesterase 4D	Homo sapiens	98-194
30526546-0	2018	Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway.	Curcumin	0-8	microRNA 99a	Homo sapiens	127-134
26711214-9	2015	RT-PCR and Western blotting results showed that the expressions of GSTP1 mRNA (0.49+-0.09) and protein (0.29+-0.07) in curcumin-treated group were significantly lower than in control group (GSTP1 mRNA 1.19+-0.21 and protein 0.70+-0.13, both P&lt;0.05), indicating that curcumin down regulated these expressions.	Curcumin	119-127	glutathione S-transferase pi 1	Homo sapiens	190-195
26711214-9	2015	RT-PCR and Western blotting results showed that the expressions of GSTP1 mRNA (0.49+-0.09) and protein (0.29+-0.07) in curcumin-treated group were significantly lower than in control group (GSTP1 mRNA 1.19+-0.21 and protein 0.70+-0.13, both P&lt;0.05), indicating that curcumin down regulated these expressions.	Curcumin	269-277	glutathione S-transferase pi 1	Homo sapiens	67-72
25452269-9	2014	Curcumin treatment upregulated the expression of PPAR-gamma and downregulated the expression of p-Smad2/3.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	49-59
26711214-10	2015	CONCLUSIONS: The suppression of GSTP1 by curcumin could enhance the vincristine chemosensitivity in HCT-8/VCR.	Curcumin	41-49	glutathione S-transferase pi 1	Homo sapiens	32-37
25452269-10	2014	These results suggest that curcumin treatment ameliorates renal fibrosis by reducing fibroblast proliferation and ECM accumulation mediated by PPAR-gamma and Smad-dependent TGF-beta1 signaling.	Curcumin	27-35	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	143-153
30526546-7	2018	Up-regulation of miR-99a was observed in curcumin-treated cells.	Curcumin	41-49	microRNA 99a	Homo sapiens	17-24
30526546-8	2018	Curcumin suppressed the phosphorylation levels of JAK1, STAT1, and STAT3, while curcumin did not inhibit the activation of JAK/STAT pathway when miR-99a was knocked down.	Curcumin	0-8	signal transducer and activator of transcription 1	Homo sapiens	56-61
30268739-0	2018	Intonation of Nrf2 and Hif1-alpha pathway by curcumin prophylaxis: A potential strategy to augment survival signaling under hypoxia.	Curcumin	45-53	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	23-33
25979368-6	2015	Here, we reported that curcumin induced apoptosis by inhibition of AKT/mTOR and ABL/STAT5 signaling, down-regulation of BCR/ABL expression, and induction of the BCL2/BAX imbalance.	Curcumin	23-31	signal transducer and activator of transcription 5A	Homo sapiens	84-89
30268739-8	2018	However, the curcumin supplementation both in-vitro and in-vivo resulted into increased expressions of HO-1 and Nrf2 significantly (p &lt; 0.001), which enabled the cells in balanced expression of SPs with reduced levels of oxidants.	Curcumin	13-21	heme oxygenase 1	Rattus norvegicus	103-107
30268739-9	2018	Further curcumin significantly enhanced the levels of antioxidant enzymes in BALF along with stabilized expression of hypoxia inducible factor 1(HIF-1alpha) followed by reduced expression of vascular endothelial growth factor (VEGF) in lungs of rats.	Curcumin	8-16	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	145-155
24036260-6	2013	Findings in the Annexin V/Propidium iodide (PI) binding based flow cytometric assays showed significant apoptosis inducing properties of the present curcumin formulation in both endothelial (HUVEC) and tumor (B16F10) cells.	Curcumin	149-157	annexin A5	Mus musculus	16-25
24036260-9	2013	Findings in both in vitro and in vivo mechanistic studies are consistent with the supposition that the presently described liposomal formulation of curcumin inhibits tumor growth by blocking VEGF-induced STAT3 phosphorylation in tumor endothelium.	Curcumin	148-156	vascular endothelial growth factor A	Mus musculus	191-195
24157330-6	2013	Using an antibody array approach, curcumin was found to inhibit LPS-induced cytokine production, including MIP-1alpha, MIP-1beta, IL-6, IL-8 (CXCL-8) and GRO-alpha.	Curcumin	34-42	C-X-C motif chemokine ligand 1	Homo sapiens	154-163
30534177-4	2018	Promoter deletion analysis demonstrated that the -177 to -83 region, which includes putative binding sites for transcription factors NFY, CREB/ATF, SP1, EGR3, and MZF1, acts as the curcumin-responsive promoter of the hST3Gal V gene.	Curcumin	181-189	cAMP responsive element binding protein 1	Homo sapiens	138-142
30534177-5	2018	Site-directed mutagenesis and chromatin immunoprecipitation analysis demonstrated that the CREB/ATF binding site at -143 is pivotal for curcumin-induced downregulation of hST3Gal V gene in HCT116 cells.	Curcumin	136-144	cAMP responsive element binding protein 1	Homo sapiens	91-95
26464670-1	2015	OBJECTIVE: This study aimed to investigate the effect of curcumin on the retinal structure and the expressions of interleukin-23 (IL-23) and IL-17 in the rat retina after retinal ischemia-reperfusion injury (RIRI).	Curcumin	57-65	interleukin 17A	Rattus norvegicus	141-146
30137697-0	2018	Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice.	Curcumin	10-18	interleukin 4 receptor, alpha	Mus musculus	141-151
30248460-0	2018	Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome inhibition.	Curcumin	0-8	thioredoxin interacting protein	Rattus norvegicus	104-109
30248460-9	2018	Curcumin, as well as allopurinol, notably up-regulated miR-200a expression, accordingly, down-regulated TXNIP and inhibited NLRP3 inflammasome activation in fructose-fed rat livers and fructose-exposed BRL-3 A and HepG2 cells.	Curcumin	0-8	thioredoxin interacting protein	Rattus norvegicus	104-109
30248460-10	2018	Taken together, this study firstly identified miR-200a as a biomarker of fructose-induced hepatic inflammation, and revealed the hepatoprotection of curcumin and allopurinol via up-regulating miR-200a-mediated TXNIP/NLRP3 inflammasome pathway.	Curcumin	149-157	thioredoxin interacting protein	Rattus norvegicus	210-215
23790945-0	2013	Binding of curcumin to beta-lactoglobulin and its effect on antioxidant characteristics of curcumin.	Curcumin	11-19	beta-lactoglobulin	Bos taurus	23-41
23790945-0	2013	Binding of curcumin to beta-lactoglobulin and its effect on antioxidant characteristics of curcumin.	Curcumin	91-99	beta-lactoglobulin	Bos taurus	23-41
23790945-1	2013	The binding of curcumin (CCM) to bovine beta-lactoglobulin (beta-Lg) was investigated by Fourier transform infrared and fluorescence.	Curcumin	15-23	beta-lactoglobulin	Bos taurus	40-58
23790945-1	2013	The binding of curcumin (CCM) to bovine beta-lactoglobulin (beta-Lg) was investigated by Fourier transform infrared and fluorescence.	Curcumin	15-23	beta-lactoglobulin	Bos taurus	60-67
23790945-1	2013	The binding of curcumin (CCM) to bovine beta-lactoglobulin (beta-Lg) was investigated by Fourier transform infrared and fluorescence.	Curcumin	25-28	beta-lactoglobulin	Bos taurus	40-58
23790945-1	2013	The binding of curcumin (CCM) to bovine beta-lactoglobulin (beta-Lg) was investigated by Fourier transform infrared and fluorescence.	Curcumin	25-28	beta-lactoglobulin	Bos taurus	60-67
30741618-6	2018	The result displayed that Curcumin pretreatment can significantly increase the expression of p-JAK2 and p-STAT3 and reduce the expression of Cr, BUN, IL-8, TNF-alpha, IL-6, and p-p65.	Curcumin	26-34	Janus kinase 2	Rattus norvegicus	95-99
29499209-1	2018	OBJECTIVE: This study is designed to investigate whether curcumin reduces excessive hepatic glucose production (HGP) via regulation of second messenger cAMP.	Curcumin	57-65	cathelicidin antimicrobial peptide	Mus musculus	152-156
26464670-11	2015	Curcumin reduced IL-23 and IL-17 expressions significantly in a dose-dependent manner (vs. MG, P&lt;0.01).	Curcumin	0-8	interleukin 17A	Rattus norvegicus	27-32
26464670-12	2015	CONCLUSION: The IL-23 and IL-17 expressions increase after RIRI and curcumin significantly reduces retinal IL-23 and IL-17 expressions in a dose-dependent manner and is able to prevent the RIRI induced damage to the retina.	Curcumin	68-76	interleukin 17A	Rattus norvegicus	26-31
23175174-10	2013	BAY 117085 and curcumin, which are two NF-kappaB inhibitors, led to a decrease in the ratio of ADAMTS9/beta-actin.	Curcumin	15-23	ADAM metallopeptidase with thrombospondin type 1 motif 9	Homo sapiens	95-102
26464670-12	2015	CONCLUSION: The IL-23 and IL-17 expressions increase after RIRI and curcumin significantly reduces retinal IL-23 and IL-17 expressions in a dose-dependent manner and is able to prevent the RIRI induced damage to the retina.	Curcumin	68-76	interleukin 17A	Rattus norvegicus	117-122
23175174-10	2013	BAY 117085 and curcumin, which are two NF-kappaB inhibitors, led to a decrease in the ratio of ADAMTS9/beta-actin.	Curcumin	15-23	POTE ankyrin domain family member F	Homo sapiens	103-113
29499209-4	2018	RESULTS: Curcumin reduced hepatic cAMP accumulation by preserving PDE4B induction, thereby suppressing gluconeogenesis via blocking cAMP/PKA activation.	Curcumin	9-17	cathelicidin antimicrobial peptide	Mus musculus	34-38
29499209-4	2018	RESULTS: Curcumin reduced hepatic cAMP accumulation by preserving PDE4B induction, thereby suppressing gluconeogenesis via blocking cAMP/PKA activation.	Curcumin	9-17	phosphodiesterase 4B, cAMP specific	Mus musculus	66-71
24142602-9	2013	Also, curcumin decreased hepatic lipogenesis such as SREBP-1, and FAS.	Curcumin	6-14	fatty acid synthase	Homo sapiens	66-69
26218133-4	2015	Following DNA damage, the Mec1-dependent DNA damage checkpoint is inactivated and Rad52 recombinase is degraded by curcumin, which results in deficiencies in double-stand break repair.	Curcumin	115-123	recombinase RAD52	Saccharomyces cerevisiae S288C	82-87
24142602-12	2013	CONCLUSIONS: These results indicated that curcumin has the same ability to activate AMPK and then reduce SREBP-1, and FAS expression, finally leading to inhibit hepatic lipogenesis and hepatic antioxidative ability.	Curcumin	42-50	fatty acid synthase	Homo sapiens	118-121
23616010-7	2013	Suppression of c-Jun/AP-1 activation using a natural inhibitor curcumin decreased the expression of caspase-3, MMP-9, and TF, as well as the proliferation and migration of SW620 cells induced by PAR2-AP or FVIIa.	Curcumin	63-71	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-20
23616010-7	2013	Suppression of c-Jun/AP-1 activation using a natural inhibitor curcumin decreased the expression of caspase-3, MMP-9, and TF, as well as the proliferation and migration of SW620 cells induced by PAR2-AP or FVIIa.	Curcumin	63-71	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	21-25
23616010-7	2013	Suppression of c-Jun/AP-1 activation using a natural inhibitor curcumin decreased the expression of caspase-3, MMP-9, and TF, as well as the proliferation and migration of SW620 cells induced by PAR2-AP or FVIIa.	Curcumin	63-71	matrix metallopeptidase 9	Homo sapiens	111-116
29499209-4	2018	RESULTS: Curcumin reduced hepatic cAMP accumulation by preserving PDE4B induction, thereby suppressing gluconeogenesis via blocking cAMP/PKA activation.	Curcumin	9-17	cathelicidin antimicrobial peptide	Mus musculus	132-136
29499209-7	2018	CONCLUSION: Curcumin reduced cAMP accumulation by preserving PDE4B activity and inhibited acetyl CoA production by reducing mitochondrial fatty acid oxidation, thereby restraining pyruvate-driven hepatic glucose production.	Curcumin	12-20	cathelicidin antimicrobial peptide	Mus musculus	29-33
29499209-7	2018	CONCLUSION: Curcumin reduced cAMP accumulation by preserving PDE4B activity and inhibited acetyl CoA production by reducing mitochondrial fatty acid oxidation, thereby restraining pyruvate-driven hepatic glucose production.	Curcumin	12-20	phosphodiesterase 4B, cAMP specific	Mus musculus	61-66
30243647-11	2018	The 5-HT1A, 5-HT2C and 5-HT4 antagonists diminished but 5-HT7 antagonist strengthened the anticonvulsant effect of curcumin.	Curcumin	115-123	basigin	Mus musculus	58-61
30243647-12	2018	Evaluation of gene expression using real-time PCR confirmed that only 5-HT7 gene expression was reduced after curcumin injection.	Curcumin	110-118	basigin	Mus musculus	72-75
30243647-13	2018	SIGNIFICANCE: According to these results, it may be suggested that curcumin exerts anticonvulsive effects by increasing the serotonin levels in the brain that influence receptors, including 5-HT1A, 5-HT2C, and 5-HT4 and likely through the reduction of 5-HT7 gene expression.	Curcumin	67-75	basigin	Mus musculus	254-257
24058438-7	2013	Curcumin also has wide pharmacokinetic effects as an inhibitor of NF-kappaB, eIF-2alpha dephosphorylation, proteasome and COX2.	Curcumin	0-8	eukaryotic translation initiation factor 2A	Homo sapiens	77-87
26218133-7	2015	In contrast, hat1 mutants were resistant to DNA damage, and Rad52 degradation was impaired following curcumin treatment.	Curcumin	101-109	histone acetyltransferase catalytic subunit HAT1	Saccharomyces cerevisiae S288C	13-17
23845850-7	2013	The intrahepatic gene or protein expression of hypoxia-inducible factor-1alpha, VEGFR-1, placental growth factor, and cyclooxygenase-2 decreased with treatment with curcumin in fibrotic rats.	Curcumin	165-173	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	47-78
23845850-7	2013	The intrahepatic gene or protein expression of hypoxia-inducible factor-1alpha, VEGFR-1, placental growth factor, and cyclooxygenase-2 decreased with treatment with curcumin in fibrotic rats.	Curcumin	165-173	placental growth factor	Rattus norvegicus	89-112
30402507-3	2018	The aim of this study was to investigate the role of curcumin in modulating the expression of IL-17 and IDO in H. pylori-infected human gastric mucosa.	Curcumin	53-61	interleukin 17A	Homo sapiens	94-99
30402507-5	2018	In H. pylori-infected patients (n = 21), IL-17 was significantly lower, both in gastric biopsies (p = 0.0003) and culture supernatant (p = 0.0001) while IDO significantly increased (p &lt; 0.00001) in curcumin-treated sample compared with untreated samples.	Curcumin	201-209	interleukin 17A	Homo sapiens	41-46
30402507-6	2018	In a subgroup of H. pylori-infected patients (n = 15), samples treated with curcumin in addition to IDO inhibitor 1-methyl-L-tryptophan (1-MT) showed a higher expression of IL-17 compared with untreated samples and curcumin-treated alone (p &lt; 0.00001).	Curcumin	76-84	interleukin 17A	Homo sapiens	173-178
30402507-6	2018	In a subgroup of H. pylori-infected patients (n = 15), samples treated with curcumin in addition to IDO inhibitor 1-methyl-L-tryptophan (1-MT) showed a higher expression of IL-17 compared with untreated samples and curcumin-treated alone (p &lt; 0.00001).	Curcumin	215-223	interleukin 17A	Homo sapiens	173-178
30402507-7	2018	Curcumin downregulates IL-17 production through the induction of IDO in H. pylori-infected human gastric mucosa, suggesting its role in dampening H. pylori-induced immune-mediated inflammatory changes.	Curcumin	0-8	interleukin 17A	Homo sapiens	23-28
23181951-7	2013	Curcumin decreased the proteinuria level and serum levels of IgG1, IgG2a and anti-dsDNA IgG antibodies in NZB/W F1 female mice.	Curcumin	0-8	LOC105243590	Mus musculus	61-65
23181951-10	2013	Interestingly, these therapeutic effects of curcumin disappeared after Treg depletion by anti-CD25 antibody injection.	Curcumin	44-52	interleukin 2 receptor, alpha chain	Mus musculus	94-98
26218133-7	2015	In contrast, hat1 mutants were resistant to DNA damage, and Rad52 degradation was impaired following curcumin treatment.	Curcumin	101-109	recombinase RAD52	Saccharomyces cerevisiae S288C	60-65
25352650-5	2015	On the other hand, curcumin co-treatment improvised enzyme activity of erythrocyte ALAD as well as Hb values.	Curcumin	19-27	aminolevulinate, delta-, dehydratase	Mus musculus	83-87
24511364-0	2013	Curcumin Regulates Colon Cancer by Inhibiting P-Glycoprotein in In-situ Cancerous Colon Perfusion Rat Model.	Curcumin	0-8	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	46-60
24511364-2	2013	In the present study curcumin inhibitory action on p-glycoprotein increased permeability of irinotecan, so in the colon cancer it would be beneficial if curcumin used as add on therapy.	Curcumin	21-29	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	51-65
24511364-2	2013	In the present study curcumin inhibitory action on p-glycoprotein increased permeability of irinotecan, so in the colon cancer it would be beneficial if curcumin used as add on therapy.	Curcumin	153-161	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	51-65
24511364-9	2013	RESULTS: Our qRT-PCR and Western blot results confirmed that about 15-fold decreases in the expression of p-glycoprotein (P-gp) in curcumin treated colon cancer cells.	Curcumin	131-139	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	106-120
24511364-9	2013	RESULTS: Our qRT-PCR and Western blot results confirmed that about 15-fold decreases in the expression of p-glycoprotein (P-gp) in curcumin treated colon cancer cells.	Curcumin	131-139	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	122-126
30119257-0	2018	Curcumin reduces Ly6Chi monocyte infiltration to protect against liver fibrosis by inhibiting Kupffer cells activation to reduce chemokines secretion.	Curcumin	0-8	lymphocyte antigen 6 complex	Mus musculus	17-20
30119257-7	2018	Compared to CCl4 group, mice in the curcumin group showed significantly less intrahepatic infiltration of Ly6Chi monocytes, but no difference of other leucocyte subtypes.	Curcumin	36-44	chemokine (C-C motif) ligand 4	Mus musculus	12-16
25938627-8	2015	However, curcumin"s effects on cell fate and fibrogenic properties of HSCs were abolished by the Hh pathway agonist SAG.	Curcumin	9-17	S-antigen visual arrestin	Rattus norvegicus	116-119
29902578-5	2018	Inducing and silencing of GATA3 were done by exposure MCF-7 cell line to nicotine or curcumin, respectively.	Curcumin	85-93	GATA binding protein 3	Homo sapiens	26-31
29644554-0	2018	Curcumin ameliorates palmitate-induced inflammation in skeletal muscle cells by regulating JNK/NF-kB pathway and ROS production.	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	91-94
25938627-10	2015	However, SAG abrogated the curcumin effects on these parameters of glycolysis.	Curcumin	27-35	S-antigen visual arrestin	Rattus norvegicus	9-12
30144665-10	2018	The findings also suggested curcumin"s potential in protecting HT22 cells against acrolein through regulating the BDNF/TrkB signaling.	Curcumin	28-36	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	119-123
23474829-0	2013	Curcumin inhibits the metastasis of K1 papillary thyroid cancer cells via modulating E-cadherin and matrix metalloproteinase-9 expression.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	100-126
25823828-7	2015	The present study revealed that curcumin was able to prevent events associated with EMT, including the downregulation of E-cadherin and the increased expression of alpha-smooth muscle actin.	Curcumin	32-40	cadherin 1	Rattus norvegicus	121-131
23347386-10	2013	Curcumin treatment reduced mRNA expression of inflammatory proteins monocyte chemoattractant protein-1 and transforming growth factor-beta and matrix proteins, fibronectin, laminin and collagen.	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	68-102
23840617-3	2013	Treatment with curcumin attenuated alloreactive T cell proliferation and inhibited the production of interferon (IFN)-gamma and interleukin (IL)-17.	Curcumin	15-23	interleukin 17A	Mus musculus	128-147
30327711-0	2018	Curcumin Inhibits Acute Vascular Inflammation through the Activation of Heme Oxygenase-1.	Curcumin	0-8	heme oxygenase 1	Oryctolagus cuniculus	72-88
30327711-4	2018	In this study, we investigate whether the anti-inflammatory effect of curcumin in vascular may be involved in the activation of HO-1.	Curcumin	70-78	heme oxygenase 1	Oryctolagus cuniculus	128-132
23840617-7	2013	The IFN-gamma-expressing CD4(+) splenocytes and IFN-gamma-expressing lymph node cells were dramatically decreased in curcumin-treated mice.	Curcumin	117-125	CD4 antigen	Mus musculus	25-28
30327711-7	2018	HO-1 inhibitor and siRNA were used to investigate the role of HO-1 in the anti-inflammatory effect of curcumin in collared vascular.	Curcumin	102-110	heme oxygenase 1	Oryctolagus cuniculus	62-66
23840617-8	2013	In contrast, CD4(+)Foxp3(+) splenocytes were increased in the curcumin-treated acute GVHD animals.	Curcumin	62-70	CD4 antigen	Mus musculus	13-16
25823828-7	2015	The present study revealed that curcumin was able to prevent events associated with EMT, including the downregulation of E-cadherin and the increased expression of alpha-smooth muscle actin.	Curcumin	32-40	actin gamma 2, smooth muscle	Rattus norvegicus	164-189
23840617-9	2013	Flow cytometric analysis revealed that animals transplanted with curcumin-treated allogeneic splenocytes showed increased populations of CD4(+) regulatory T cells (Tregs) as well as CD8(+) Treg cells, compared to animals administered vehicle-treated splenocytes.	Curcumin	65-73	CD4 antigen	Mus musculus	137-140
30327711-8	2018	We also explored the mechanism of curcumin-induced activation of HO-1 in vitro.	Curcumin	34-42	heme oxygenase 1	Oryctolagus cuniculus	65-69
23840617-13	2013	Curcumin exerted in vivo preventive effects on acute GVHD by reciprocal regulation of T helper 1 (Th1) and Treg (both CD4(+) and CD8(+) Treg) cell lineages as well as B cell homeostasis.	Curcumin	0-8	CD4 antigen	Mus musculus	118-121
25791922-4	2015	Curcumin treatment in the hippocampus or SH-SY5Y cells inhibited IRE1alpha and PERK phosphorylation with suppression of intracellular ROS production.	Curcumin	0-8	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	79-83
25791922-5	2015	Curcumin increased AMPK activity and knockdown of AMPKalpha with specific siRNA abrogated its inhibitory effects on IRE1alpha and PERK phosphorylation, indicating that AMPK activity was essential for the suppression of ER stress.	Curcumin	0-8	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	130-134
23686430-0	2013	Curcumin induces apoptosis in human colorectal carcinoma (HCT-15) cells by regulating expression of Prp4 and p53.	Curcumin	0-8	pre-mRNA processing factor 4B	Homo sapiens	100-104
23686430-6	2013	Western blot analysis revealed that curcumin treatment activated caspase-3 and decreased expression of p53 and Prp4B in a time-dependent manner.	Curcumin	36-44	pre-mRNA processing factor 4B	Homo sapiens	111-116
23686430-7	2013	Transfection of HCT-15 cells with Prp4B clone perturbed the growth inhibition induced by 30 muM curcumin.	Curcumin	96-104	pre-mRNA processing factor 4B	Homo sapiens	34-39
23686430-10	2013	Knockdown of Prp4B with siRNA diminished the protective effects of Prp4B against curcumin-induced apoptosis.	Curcumin	81-89	pre-mRNA processing factor 4B	Homo sapiens	13-18
23686430-10	2013	Knockdown of Prp4B with siRNA diminished the protective effects of Prp4B against curcumin-induced apoptosis.	Curcumin	81-89	pre-mRNA processing factor 4B	Homo sapiens	67-72
25791922-9	2015	Immunohistochemistry showed that curcumin inhibited p-IRE1alpha, p-PERK and NLRP3 expression in hippocampus CA1 region.	Curcumin	33-41	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	67-71
26170618-8	2015	The results indicated that curcumin and salvianolic acid C can effectively inhibit hHMGR, with IC50 (half maximal inhibitory concentration) values of 4.3 microM and 8 microM, respectively.	Curcumin	27-35	high mobility group AT-hook 1	Homo sapiens	83-88
23560895-0	2013	Long-term ethanol exposure-induced hepatocellular carcinoma cell migration and invasion through lysyl oxidase activation are attenuated by combined treatment with pterostilbene and curcumin analogues.	Curcumin	181-189	lysyl oxidase	Homo sapiens	96-109
29807115-0	2018	Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1.	Curcumin	0-8	sirtuin 1	Homo sapiens	112-117
29807115-5	2018	In the present study, we found that curcumin reduced the expression of SIRT1 protein without influencing its mRNA expression in human colon cancer cells, suggesting posttranslational regulation of SIRT1 by this phytochemical.	Curcumin	36-44	sirtuin 1	Homo sapiens	71-76
29807115-5	2018	In the present study, we found that curcumin reduced the expression of SIRT1 protein without influencing its mRNA expression in human colon cancer cells, suggesting posttranslational regulation of SIRT1 by this phytochemical.	Curcumin	36-44	sirtuin 1	Homo sapiens	197-202
29807115-6	2018	Notably, ubiquitination and subsequent proteasomal degradation of SIRT1 were induced by curcumin treatment.	Curcumin	88-96	sirtuin 1	Homo sapiens	66-71
29807115-7	2018	Results of nano-LC-ESI-MS/MS revealed the direct binding of curcumin to cysteine 67 of SIRT1.	Curcumin	60-68	sirtuin 1	Homo sapiens	87-92
26309547-0	2015	Curcumin inhibits lung cancer invasion and metastasis by attenuating GLUT1/MT1-MMP/MMP2 pathway.	Curcumin	0-8	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	69-74
29807115-9	2018	Taken together, these observations suggest that curcumin facilitates the proteasomal degradation of oncogenic SIRT1 through covalent modification of SIRT1 at the cysteine 67 residue.	Curcumin	48-56	sirtuin 1	Homo sapiens	110-115
29807115-9	2018	Taken together, these observations suggest that curcumin facilitates the proteasomal degradation of oncogenic SIRT1 through covalent modification of SIRT1 at the cysteine 67 residue.	Curcumin	48-56	sirtuin 1	Homo sapiens	149-154
23313051-4	2013	CCN4-induced VCAM-1 expression was attenuated by alphavbeta5 or alpha6beta1 integrin antibody, Syk inhibitor, PKCdelta inhibitor (rottlerin), JNK inhibitor (SP600125), and AP-1 inhibitors (curcumin and tanshinone).	Curcumin	189-197	cellular communication network factor 4	Homo sapiens	0-4
30130550-0	2018	Upregulation of klotho and erythropoietin contributes to the neuroprotection induced by curcumin-loaded nanoparticles in experimental model of chronic epilepsy.	Curcumin	88-96	klotho	Mus musculus	16-22
26309547-3	2015	This study aimed at evaluating whether attenuating GLUT1 was involved in curcumin"s anti-invasion and metastasis effects.	Curcumin	73-81	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	51-56
30130550-2	2018	The present study is an attempt to examine the potential role of klotho and EPO in therapeutic effect of curcumin-loaded nanoparticles (NPs) in pentylenetetrazol (PTZ)-induced kindling model.	Curcumin	105-113	klotho	Mus musculus	65-71
23467542-5	2013	Both NF-kappaB inhibitor PDTC (20 muM) and AP-1 inhibitor curcumin (25 mM) could attenuate TF expression induced by anti-beta2GPI/beta2GPI or APS-IgG/beta2GPI complex.	Curcumin	58-66	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	43-47
23333261-9	2013	Moreover, curcumin alleviated Sim2 expression, and reversely raised Drebrin expression in neurons treated with hyperglycaemia.	Curcumin	10-18	drebrin 1	Rattus norvegicus	68-75
30130550-10	2018	Curcumin-loaded NPs effectively upregulated the levels of EPO and klotho in PTZ receiving animals.	Curcumin	0-8	klotho	Mus musculus	66-72
26309547-7	2015	Real-time PCR and Western-blotting were employed to examine the expression levels of GLUT1, membrane type 1-MMP (MT1-MMP) and matrix metalloproteinase (MMP) 2 in curcumin- incubated A549 cells.	Curcumin	162-170	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	85-90
30130550-12	2018	Overall, the results of this study suggest that downregulation of TNF-alpha and consequent upregulation of klotho and EPO might contribute to the neuroprotective effect of curcumin-loaded NPs in experimental model of epilepsy.	Curcumin	172-180	klotho	Mus musculus	107-113
26309547-10	2015	Curcumin inhibited invasion and expressions of GLUT1, MT1-MMP and MMP2 untransfected A549 cells in a concentration-dependent manner.	Curcumin	0-8	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	47-52
26309547-11	2015	pcDNA3.1-GLUT1 transfected A549 cells exhibited resistance to curcumin"s anti-invasion effect by up-regulating expressions of GLUT2, MT1-MMP and MMP2.	Curcumin	62-70	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	9-14
26309547-13	2015	These results suggested that curcumin inhibit lung cancer invasion and metastasis by attenuating GLUT1/MT1-MMP/MMP2 pathway.	Curcumin	29-37	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	97-102
23147641-5	2013	After the treatment with equimolar concentration of curcumin, 7T cells exhibited lower intracellular accumulation of curcumin which coincided with reduced formation of reactive oxygen species (ROS), diminished lipid and DNA damage followed by reduced induction of apoptosis and expression of heat shock protein 70 (Hsp70), as compared to parental HEp-2 cells.	Curcumin	52-60	heat shock protein family A (Hsp70) member 4	Homo sapiens	292-313
25862641-0	2015	Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2.	Curcumin	0-8	toll like receptor 4	Homo sapiens	59-63
23147641-5	2013	After the treatment with equimolar concentration of curcumin, 7T cells exhibited lower intracellular accumulation of curcumin which coincided with reduced formation of reactive oxygen species (ROS), diminished lipid and DNA damage followed by reduced induction of apoptosis and expression of heat shock protein 70 (Hsp70), as compared to parental HEp-2 cells.	Curcumin	52-60	heat shock protein family A (Hsp70) member 4	Homo sapiens	315-320
29775223-0	2018	Curcumin down-regulates IL-17A mediated p53-fibrinolytic system in bleomycin induced acute lung injury in vivo.	Curcumin	0-8	interleukin 17A	Mus musculus	24-30
23380686-9	2013	The present study indicates beneficial effect of curcumin in diabetic rats by regulating the cholinergic, insulin receptor and GLUT-3 in the brainstem similar to the responses obtained with insulin therapy.	Curcumin	49-57	solute carrier family 2 member 3	Rattus norvegicus	127-133
23294827-2	2013	Curcumin up-regulates heat shock protein 70 (hsp70) mRNA in several different cancer cell lines.	Curcumin	0-8	heat shock protein family A (Hsp70) member 4	Homo sapiens	45-50
23294827-3	2013	Hsp70 contributes to an escape from the apoptotic effects of curcumin by several different mechanisms including prevention of the release of apoptosis inducing factor from the mitochondria and inhibition of caspases 3 and 9.	Curcumin	61-69	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
30018000-6	2018	The curcumin treatment increased expression of compact myelin proteins (MPZ and PMP22), myelin sheath thickness and, correspondingly, increased motor and sensitive nerve conduction velocity.	Curcumin	4-12	peripheral myelin protein 22	Rattus norvegicus	80-85
23294827-4	2013	Previously we showed that the combination of curcumin plus a heat shock protein inhibitor was synergistic in its down-regulation of the proliferation of a human schwannoma cell line (HEI-193) harboring an NF2 mutation, possibly because curcumin up-regulated hsp70, which also binds merlin, the NF2 gene product.	Curcumin	45-53	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	205-208
26199609-1	2015	Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown.	Curcumin	0-8	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	92-97
23294827-4	2013	Previously we showed that the combination of curcumin plus a heat shock protein inhibitor was synergistic in its down-regulation of the proliferation of a human schwannoma cell line (HEI-193) harboring an NF2 mutation, possibly because curcumin up-regulated hsp70, which also binds merlin, the NF2 gene product.	Curcumin	45-53	heat shock protein family A (Hsp70) member 4	Homo sapiens	258-263
23294827-4	2013	Previously we showed that the combination of curcumin plus a heat shock protein inhibitor was synergistic in its down-regulation of the proliferation of a human schwannoma cell line (HEI-193) harboring an NF2 mutation, possibly because curcumin up-regulated hsp70, which also binds merlin, the NF2 gene product.	Curcumin	45-53	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	282-288
23294827-4	2013	Previously we showed that the combination of curcumin plus a heat shock protein inhibitor was synergistic in its down-regulation of the proliferation of a human schwannoma cell line (HEI-193) harboring an NF2 mutation, possibly because curcumin up-regulated hsp70, which also binds merlin, the NF2 gene product.	Curcumin	45-53	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	294-297
23294827-7	2013	Peptides pulled down from this reaction were sequenced and it was determined that biotinylated curcumin bound hsp70, hsp90, 3-phosphoglycerate dehydrogenase, and a beta-actin variant.	Curcumin	95-103	heat shock protein family A (Hsp70) member 4	Homo sapiens	110-115
23134146-0	2013	Continuous exercise training and curcumin attenuate changes in brain-derived neurotrophic factor and oxidative stress induced by lead acetate in the hippocampus of male rats.	Curcumin	33-41	brain-derived neurotrophic factor	Rattus norvegicus	63-96
23134146-10	2013	Treadmill running, curcumin supplementation or both resulted in a significant decrease in hippocampus MDA (17, 20, 31%, respectively) and plasma MDA (60, 22, 71%) and also, significantly increased brain-derived neurotrophic factor (76, 45, 94%) and total antioxidant capacity (47.13, 47.11, 61%) levels, as compared to lead acetate group.	Curcumin	19-27	brain-derived neurotrophic factor	Rattus norvegicus	197-230
23710741-0	2013	[Curcumin attenuates contrast-induced nephropathy by upregulating heme oxygenase-1 expression in rat].	Curcumin	1-9	heme oxygenase 1	Rattus norvegicus	66-82
24117066-0	2013	Curcumin induces ABCA1 expression and apolipoprotein A-I-mediated cholesterol transmembrane in the chronic cerebral hypoperfusion aging rats.	Curcumin	0-8	ATP binding cassette subfamily A member 1	Rattus norvegicus	17-22
24117066-5	2013	In this study, we evaluated the effects of curcumin on the cholesterol level in brain, vascular cognitive impairment and explored whether the mechanisms for those effects are through activating LXR-beta/RXR-alpha and ABCA1 expression and apoA-I.	Curcumin	43-51	ATP binding cassette subfamily A member 1	Rattus norvegicus	217-222
24117066-8	2013	Meanwhile, the expression of LXR-beta, RXR-alpha, ABCA1 and apoA-I mRNA and protein were increased in a dose-dependent manner after curcumin treatment.	Curcumin	132-140	ATP binding cassette subfamily A member 1	Rattus norvegicus	50-55
24117066-10	2013	We conclude that curcumin has the ability to activate permissive LXR-beta/RXR-alpha signaling and thereby modulate ABCA1 and apoA-I-mediated cholesterol transmembrane transportation, which is a new preventive and therapeutic strategy for cerevascular diseases.	Curcumin	17-25	ATP binding cassette subfamily A member 1	Rattus norvegicus	115-120
23325575-7	2013	Curcumin up-regulated expression of SOD genes and down-regulated expression of several age-related genes, such as dInR, ATTD, Def, CecB, and DptB.	Curcumin	0-8	Insulin-like receptor	Drosophila melanogaster	114-118
23325575-7	2013	Curcumin up-regulated expression of SOD genes and down-regulated expression of several age-related genes, such as dInR, ATTD, Def, CecB, and DptB.	Curcumin	0-8	Cecropin B	Drosophila melanogaster	131-135
23762140-9	2013	All the above protective effects of curcumin on cerebral ischemic injury were markedly attenuated by GW9662, an inhibitor of PPAR gamma .	Curcumin	36-44	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	125-135
23762140-10	2013	Our results as described above suggested that PPAR gamma induced by curcumin may play a critical role in protecting against brain injury through suppression of inflammatory response.	Curcumin	68-76	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	46-56
24453411-3	2013	Molecular mechanisms of cytokine activities were controlled by NF-kappaB and JAK/STAT signaling pathways, as metabolic inhibitors, curcumin and AG490, inhibited some of TNF-alpha and IFNalpha/IFNgamma effects.	Curcumin	131-139	interferon alpha	Mus musculus	183-191
23124098-9	2013	The results presented in our study suggest that curcumin enhances the expression of HO-1 to reduce the LPS-induced production of ROS, which leads to the inhibition of MCP-1 expression in RAW264.7 macrophages.	Curcumin	48-56	chemokine (C-C motif) ligand 2	Mus musculus	167-172
23533564-6	2013	RESULTS AND CONCLUSIONS: Curcumin exhibited inhibitory potency against human and rat 11beta-HSD1 in intact cells with IC50 values of 2.29 and 5.79 microM, respectively, with selectivity against 11beta-HSD2 (IC50, 14.56 and 11.92 microM).	Curcumin	25-33	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	194-205
23457487-0	2013	Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.	Curcumin	0-8	DNA methyltransferase 1	Homo sapiens	24-47
23042094-0	2012	Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2.	Curcumin	0-8	C-X-C motif chemokine ligand 1	Homo sapiens	93-105
23042094-3	2012	We previously reported that the chemopreventive polyphenol curcumin inhibits the expression of the proinflammatory cytokines CXCL1 and -2 leading to diminished formation of breast cancer metastases.	Curcumin	59-67	C-X-C motif chemokine ligand 1	Homo sapiens	125-137
23042094-8	2012	Treatment of the cells with curcumin and siRNA-based knockdown of CXCL1 and -2 induce apoptosis, inhibit proliferation and downregulate several important metastasis-promoting factors like COX2, SPARC and EFEMP.	Curcumin	28-36	C-X-C motif chemokine ligand 1	Homo sapiens	66-78
22492920-3	2012	We aimed to investigate whether curcumin upregulates heme oxygenase 1 (HO-1) expression and ameliorates lung injury in a rat CPB model.	Curcumin	32-40	heme oxygenase 1	Rattus norvegicus	53-69
22492920-3	2012	We aimed to investigate whether curcumin upregulates heme oxygenase 1 (HO-1) expression and ameliorates lung injury in a rat CPB model.	Curcumin	32-40	heme oxygenase 1	Rattus norvegicus	71-75
22492920-10	2012	Furthermore, HO-1 gene transcription and protein expression were elevated to a greater extent in the lungs after curcumin pretreatment compared with the vehicle pretreatment.	Curcumin	113-121	heme oxygenase 1	Rattus norvegicus	13-17
22492920-12	2012	The antioxidant effect of curcumin may be partly related to upregulation of HO-1.	Curcumin	26-34	heme oxygenase 1	Rattus norvegicus	76-80
23194063-9	2012	CONCLUSIONS: These results identify a new and highly potent curcumin derivative and demonstrate that in cells where curcumin and RL197 induce ROS, an important underlying mechanism of action involves perturbation of miR-ZBTB10/ZBTB4, resulting in the induction of these repressors which downregulate Sp transcription factors and Sp-regulated genes.	Curcumin	60-68	zinc finger and BTB domain containing 4	Homo sapiens	227-232
23194063-9	2012	CONCLUSIONS: These results identify a new and highly potent curcumin derivative and demonstrate that in cells where curcumin and RL197 induce ROS, an important underlying mechanism of action involves perturbation of miR-ZBTB10/ZBTB4, resulting in the induction of these repressors which downregulate Sp transcription factors and Sp-regulated genes.	Curcumin	116-124	zinc finger and BTB domain containing 4	Homo sapiens	227-232
23058916-5	2012	We investigated the sensitivity of cysteine mutated Orai1 to curcumin and CAPE to delineate their inhibitory mechanism.	Curcumin	61-69	ORAI calcium release-activated calcium modulator 1	Homo sapiens	52-57
23058916-7	2012	Tetrahydrocurcumin, a curcumin metabolite, showed a less potent inhibitory effect on I(CRAC), and this effect was abolished in C195S Orai1.	Curcumin	10-18	ORAI calcium release-activated calcium modulator 1	Homo sapiens	133-138
23058916-9	2012	These results indicate that the electrophilic addition to the Orai1 195Cys was responsible for the inhibitory effect of I(CRAC) by curcumin and CAPE.	Curcumin	131-139	ORAI calcium release-activated calcium modulator 1	Homo sapiens	62-67
22402368-7	2012	Ex vivo and in vitro treatment with curcumin resulted in a dose-dependent decrease in the secretion of IFNgamma, IL-17, IL-12 and IL-23 in culture.	Curcumin	36-44	interleukin 17A	Mus musculus	113-118
22402368-8	2012	The inhibition of EAE by curcumin was also associated with an up-regulation of IL-10, peroxisome proliferator activated receptor gamma and CD4(+)CD25(+-)Foxp3(+) Treg cells in the CNS and lymphoid organs.	Curcumin	25-33	CD4 antigen	Mus musculus	139-142
22402368-9	2012	These findings highlight that curcumin differentially regulates CD4(+) T helper cell responses in EAE.	Curcumin	30-38	CD4 antigen	Mus musculus	64-67
22564708-2	2012	Curcumin is a naturally occurring compound which is known to inhibit PKC activity.	Curcumin	0-8	protein kinase C, alpha	Rattus norvegicus	69-72
22564708-4	2012	We evaluated whether curcumin treatment is associated with the modulation of PKC-alpha and -beta2-mitogen-activated protein kinase (MAPK) pathway in experimental diabetic cardiomyopathy.	Curcumin	21-29	protein kinase C, alpha	Rattus norvegicus	77-86
22564708-7	2012	We demonstrate that curcumin significantly prevented diabetes-induced translocation of PKC-alpha and -beta2 to membranous fraction and diabetes-induced increased phosphorylation of p38MAPK and extracellular regulated-signal kinase (ERK)1/2 in left ventricular tissues of diabetic rats.	Curcumin	20-28	protein kinase C, alpha	Rattus norvegicus	87-96
22564708-8	2012	Curcumin treatment also markedly decreased NAD(P)H oxidase subunits (p67phox, p22phox, gp91phox), growth factors (transforming growth factor-beta, osteopontin) and myocyte enhancer factor-2 protein expression as well as inhibited NF-kappaB activity at nuclear level.	Curcumin	0-8	cytochrome b-245 beta chain	Rattus norvegicus	87-95
22564708-11	2012	Taken together, it is suggested that curcumin by inhibiting PKC-alpha and -beta2-MAPK pathway may be useful as an adjuvant therapy for the prevention of diabetic cardiomyopathy.	Curcumin	37-45	protein kinase C, alpha	Rattus norvegicus	60-69
22765290-3	2012	In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53.	Curcumin	96-104	beclin 1	Homo sapiens	288-296
22765290-3	2012	In this review, we focus on highlighting several representative plant natural compounds such as curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin - that may lead to cancer cell death - for regulation of some core autophagic pathways, involved in Ras-Raf signalling, Beclin-1 interactome, BCR-ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53.	Curcumin	96-104	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	310-317
22954786-8	2012	Knocking down both p300/CBP by RNAi or by chemical inhibition with curcumin greatly reduced XPG acetylation, and a concomitant accumulation of the protein at DNA damage sites was observed.	Curcumin	67-75	ERCC excision repair 5, endonuclease	Homo sapiens	92-95
23435139-8	2012	In contrast, the levels of HO-1 protein in the curcumin group were high at the preoperative phase, and thereafter remained at high levels until day 7 following surgery.	Curcumin	47-55	heme oxygenase 1	Rattus norvegicus	27-31
22156994-10	2012	In the preclinical trial with rodent models, curcumin reduced Stat3-P and the proliferative markers CycD1 and Mcm2 in mice lung tissues in vivo.	Curcumin	45-53	cyclin D1	Mus musculus	100-105
22683883-0	2012	Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression.	Curcumin	22-30	high mobility group box 1	Rattus norvegicus	103-128
22683883-7	2012	Moreover, curcumin significantly inhibited extracellular matrix deposition, reduced the number of activated stellate cells, and decreased the levels of HMGB1, TLR4 and TLR2 expression in the rat model of fibrogenesis.	Curcumin	10-18	high mobility group box 1	Rattus norvegicus	152-157
22683883-8	2012	These results suggest that curcumin could be an effective agent for preventing liver fibrosis and its mechanism may in part be a consequence of the reduction TLR2, TLR4 and HMGB1 expression.	Curcumin	27-35	high mobility group box 1	Rattus norvegicus	173-178
22692588-5	2012	We demonstrate that curcumin effectively suppressed HFFA-induced production of phosphoenol pyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) in hepatocytes.	Curcumin	20-28	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	79-113
22692588-5	2012	We demonstrate that curcumin effectively suppressed HFFA-induced production of phosphoenol pyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) in hepatocytes.	Curcumin	20-28	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	115-120
22352842-0	2012	Curcumin inhibits gene expression of receptor for advanced glycation end-products (RAGE) in hepatic stellate cells in vitro by elevating PPARgamma activity and attenuating oxidative stress.	Curcumin	0-8	advanced glycosylation end-product specific receptor	Homo sapiens	83-87
22352842-6	2012	We hypothesize that curcumin eliminates the effects of AGEs by suppressing gene expression of RAGE.	Curcumin	20-28	advanced glycosylation end-product specific receptor	Homo sapiens	94-98
22352842-13	2012	In addition, curcumin attenuated AGEs-induced oxidative stress in HSCs by elevating the activity of glutamate-cysteine ligase and by stimulating de novo synthesis of glutathione, leading to the suppression of gene expression of RAGE.	Curcumin	13-21	advanced glycosylation end-product specific receptor	Homo sapiens	228-232
22352842-14	2012	CONCLUSION AND IMPLICATIONS: Curcumin suppressed gene expression of RAGE by elevating the activity of PPARgamma and attenuating oxidative stress, leading to the elimination of the AGE effects on the activation of HSCs.	Curcumin	29-37	advanced glycosylation end-product specific receptor	Homo sapiens	68-72
22620965-2	2012	We found that epigallocatechin-3-gallate (EGCG), curcumin and nordihydroguaiaretic acid (NDGA) bind to TTR and modulate its amyloidogenicity, in vitro, although through different mechanisms of action.	Curcumin	49-57	transthyretin	Mus musculus	103-106
21932059-0	2012	ICAM-1 and IL-8 are expressed by DEHP and suppressed by curcumin through ERK and p38 MAPK in human umbilical vein endothelial cells.	Curcumin	56-64	intercellular adhesion molecule 1	Homo sapiens	0-6
21932059-5	2012	Pretreatment with curcumin dose-dependently decreased DEHP-induced expression of ICAM-1 and IL-8 as well as phosphorylation of ERK1/2 and p38.	Curcumin	18-26	intercellular adhesion molecule 1	Homo sapiens	81-87
21932059-7	2012	We suggest that curcumin inhibits DEHP-induced expression of ICAM-1 and IL-8 through ERK and p38 MAPK signaling pathways in HUVECs and may contribute to ameliorate pathologies of DEHP-related allergic disorders.	Curcumin	16-24	intercellular adhesion molecule 1	Homo sapiens	61-67
22297615-0	2012	Curcumin causes promoter hypomethylation and increased  expression of FANCF gene in SiHa cell line.	Curcumin	0-8	FA complementation group F	Homo sapiens	70-75
22297615-1	2012	Curcumin and resveratrol were evaluated for their potential to cause reversal of promoter hypermethylation and associated gene expression of FANCF in SiHa cell line.	Curcumin	0-8	FA complementation group F	Homo sapiens	141-146
22297615-2	2012	Methylation specific PCR along with bisulphite sequencing revealed the demethylation of 12 CpG sites out of 15 CpG sites spanning ?280 to ?432 region of FANCF promoter after treatment with curcumin and fivefold up regulation of FANCF gene expression as shown by qRT-PCR.	Curcumin	189-197	FA complementation group F	Homo sapiens	153-158
22297615-2	2012	Methylation specific PCR along with bisulphite sequencing revealed the demethylation of 12 CpG sites out of 15 CpG sites spanning ?280 to ?432 region of FANCF promoter after treatment with curcumin and fivefold up regulation of FANCF gene expression as shown by qRT-PCR.	Curcumin	189-197	FA complementation group F	Homo sapiens	228-233
22297615-3	2012	In vitro methylation assay also showed that M.SssI an analogue of DNMT1 was effectively inhibited at 50 lM concentration of curcumin.	Curcumin	124-132	DNA methyltransferase 1	Homo sapiens	66-71
22466958-0	2012	The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway.	Curcumin	15-23	Janus kinase 2	Rattus norvegicus	104-108
29987021-0	2018	Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2.	Curcumin	13-21	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	Mus musculus	78-122
29987021-3	2018	Here we identify dual-specificity tyrosine-regulated kinase 2 (DYRK2), a positive regulator of the 26S proteasome, as a direct target of curcumin.	Curcumin	137-145	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	Mus musculus	17-61
29987021-3	2018	Here we identify dual-specificity tyrosine-regulated kinase 2 (DYRK2), a positive regulator of the 26S proteasome, as a direct target of curcumin.	Curcumin	137-145	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	Mus musculus	63-68
29987021-4	2018	Curcumin occupies the ATP-binding pocket of DYRK2 in the cocrystal structure, and it potently and specifically inhibits DYRK2 over 139 other kinases tested in vitro.	Curcumin	0-8	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	Mus musculus	44-49
29987021-4	2018	Curcumin occupies the ATP-binding pocket of DYRK2 in the cocrystal structure, and it potently and specifically inhibits DYRK2 over 139 other kinases tested in vitro.	Curcumin	0-8	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	Mus musculus	120-125
29987021-5	2018	As a result, curcumin diminishes DYRK2-mediated 26S proteasome phosphorylation in cells, leading to reduced proteasome activity and impaired cell proliferation.	Curcumin	13-21	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	Mus musculus	33-38
29987021-7	2018	In a breast cancer xenograft model, curcumin treatment significantly reduces tumor burden in immunocompromised mice, showing a similar antitumor effect as CRISPR/Cas9-mediated DYRK2 depletion.	Curcumin	36-44	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	Mus musculus	176-181
29987021-8	2018	These results reveal an unexpected role of curcumin in DYRK2-proteasome inhibition and provide a proof-of-concept that pharmacological manipulation of proteasome regulators may offer new opportunities for anticancer treatment.	Curcumin	43-51	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	Mus musculus	55-60
29869202-7	2018	The phosphorylation of JNK (c-Jun NH2 terminal kinase) and HLJ1 expression levels in the lung metastatic nodules of the melanoma were significantly increased by pulmonary curcumin administration.	Curcumin	171-179	mitogen-activated protein kinase 8	Mus musculus	23-26
29869202-7	2018	The phosphorylation of JNK (c-Jun NH2 terminal kinase) and HLJ1 expression levels in the lung metastatic nodules of the melanoma were significantly increased by pulmonary curcumin administration.	Curcumin	171-179	mitogen-activated protein kinase 8	Mus musculus	28-53
29808357-7	2018	Administrations of BLM and IL-17A to the alveolar basal epithelial cells showed significant down-regulation of Akt expression which was reversed by treatment with curcumin.	Curcumin	163-171	interleukin 17A	Homo sapiens	27-33
29808357-8	2018	BLM and IL-17A mediated inflammation was intervened effectively with curcumin.	Curcumin	69-77	interleukin 17A	Homo sapiens	8-14
29938313-0	2018	The Effect of BSA-Based Curcumin Nanoparticles on Memory and Hippocampal MMP-2, MMP-9, and MAPKs in Adult Mice.	Curcumin	24-32	matrix metallopeptidase 2	Mus musculus	73-78
29938313-11	2018	This study indicates that breaking curcumin to nanosize produces improved effects on passive avoidance memory in adult mice accompanied with MMP-2, MMP-9, p-ERK, and p-JNK changes in the hippocampus.	Curcumin	35-43	matrix metallopeptidase 2	Mus musculus	141-146
29938313-11	2018	This study indicates that breaking curcumin to nanosize produces improved effects on passive avoidance memory in adult mice accompanied with MMP-2, MMP-9, p-ERK, and p-JNK changes in the hippocampus.	Curcumin	35-43	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	155-160
29938313-11	2018	This study indicates that breaking curcumin to nanosize produces improved effects on passive avoidance memory in adult mice accompanied with MMP-2, MMP-9, p-ERK, and p-JNK changes in the hippocampus.	Curcumin	35-43	mitogen-activated protein kinase 8	Mus musculus	168-171
29800814-8	2018	Mechanistically, curcumin may repress mTORC1 by preventing TSC2 degradation, the conserved inhibitor of mTORC1.	Curcumin	17-25	TSC complex subunit 2	Homo sapiens	59-63
29723552-6	2018	Decreased levels of BDNF, pAkt, pERK1/2, pGSK3beta and pCREB on sodium arsenite exposure were also protected by curcumin.	Curcumin	112-120	brain-derived neurotrophic factor	Rattus norvegicus	20-24
29723552-10	2018	The results provide evidence that curcumin exercises its neuroprotective effect involving PI3K/Akt pathway which may affect NMDA receptors and downstream signalling through TrKbeta and BDNF in arsenic induced cognitive deficits in hippocampus.	Curcumin	34-42	brain-derived neurotrophic factor	Rattus norvegicus	185-189
30058275-3	2018	Furthermore, oral supplementation with curcumin that increased IAP activity improved intestinal barrier function as well as glucose tolerance.	Curcumin	39-47	alkaline phosphatase 3, intestine, not Mn requiring	Mus musculus	63-66
29642292-5	2018	We found that curcumin had an immune-stimulatory effect on NK-92 by increasing the surface expression of the CD16+ and CD56dim population of NK-92.	Curcumin	14-22	Fc gamma receptor IIIa	Homo sapiens	109-113
29642292-6	2018	We confirmed that the cytotoxic effect of NK-92 on MDA-MB-231 was significantly enhanced in the presence of curcumin, which was highly associated with the activation of Stat4 and Stat5 proteins in NK-92.	Curcumin	108-116	signal transducer and activator of transcription 4	Homo sapiens	169-174
29804421-5	2018	Both DAPT and curcumin-PDT can inhibit the protein expression of Notch1, NF-kappaB and VEGF, and two of them have synergistic effect after combined use.	Curcumin	14-22	vascular endothelial growth factor A	Mus musculus	87-91
29432829-12	2018	VDR promoter methylation by (MS-qPCR) was decreased and the relative expression of VDR by (qRT-PCR) was markedly increased in a dose-dependent fashion in cells grown in Curcumin-adequate medium.	Curcumin	169-177	vitamin D receptor	Homo sapiens	0-3
29432829-12	2018	VDR promoter methylation by (MS-qPCR) was decreased and the relative expression of VDR by (qRT-PCR) was markedly increased in a dose-dependent fashion in cells grown in Curcumin-adequate medium.	Curcumin	169-177	vitamin D receptor	Homo sapiens	83-86
28965778-0	2018	The effects of curcumin on brain-derived neurotrophic factor and cognition in schizophrenia: A randomized controlled study.	Curcumin	15-23	brain derived neurotrophic factor	Homo sapiens	27-60
29657313-12	2018	Moreover, the phosphorylation levels of mitogen-activated protein kinase (MAPK) kinase 4 (MKK4), MKK7, and c-Jun NH(2)-terminal protein kinase (JNK) were reduced by curcumin pre-treatment.	Curcumin	165-173	mitogen activated protein kinase kinase 4	Rattus norvegicus	90-94
29657313-12	2018	Moreover, the phosphorylation levels of mitogen-activated protein kinase (MAPK) kinase 4 (MKK4), MKK7, and c-Jun NH(2)-terminal protein kinase (JNK) were reduced by curcumin pre-treatment.	Curcumin	165-173	mitogen activated protein kinase kinase 7	Rattus norvegicus	97-101
29615146-1	2018	The aim of this study is to investigate the pharmacological effect of curcumin on hepatocellular carcinoma (HCC) Huh7 and PLC cells and to explore its mechanism in the pathological process by screening possible target genes.	Curcumin	70-78	MIR7-3 host gene	Homo sapiens	113-117
29615146-2	2018	MTT assay was used to detect the effect of curcumin on the growth of Huh7 and PLC cells.	Curcumin	43-51	MIR7-3 host gene	Homo sapiens	69-73
29615146-4	2018	Flow cytometry indicated that curcumin could significantly accelerate apoptosis of Huh7 and PLC cells, showing an obvious dosage effect.	Curcumin	30-38	MIR7-3 host gene	Homo sapiens	83-87
29420338-9	2018	After curcumin treatment, drug-resistant cell proliferation was significantly inhibited; in the curcumin+irinotecan treatment group, E-cadherin expression was upregulated, whereas vimentin and N-cadherin expressions were downregulated.	Curcumin	96-104	cadherin 2	Homo sapiens	193-203
29485312-3	2018	Most of the beneficial effects of Curcumin are possibly due to activation of the nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARgamma).	Curcumin	34-42	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	99-147
29466778-0	2018	New MD2 inhibitors derived from curcumin with improved anti-inflammatory activity.	Curcumin	32-40	lymphocyte antigen 96	Homo sapiens	4-7
29466778-2	2018	The natural product curcumin is reported to inhibit the TLR4 co-receptor, MD2 (myeloid differentiation protein 2), but its low in vivo bioavailability limits its therapeutic potential.	Curcumin	20-28	lymphocyte antigen 96	Homo sapiens	74-77
29466778-2	2018	The natural product curcumin is reported to inhibit the TLR4 co-receptor, MD2 (myeloid differentiation protein 2), but its low in vivo bioavailability limits its therapeutic potential.	Curcumin	20-28	lymphocyte antigen 96	Homo sapiens	79-112
29466778-3	2018	We developed new curcumin analogs (MACs) with removal of the beta-diketone moiety and substituted residues in benzene rings, and identify these as potential MD2 inhibitors with improved inhibition potency and stability over that of curcumin.	Curcumin	17-25	lymphocyte antigen 96	Homo sapiens	157-160
29655698-0	2018	Down-regulation of lncRNA, GAS5 decreases chemotherapeutic effect of dendrosomal curcumin (DNC) in breast cancer cells.	Curcumin	81-89	growth arrest specific 5	Homo sapiens	27-31
22509079-10	2012	Pretreatment with curcumin significantly decreased the elevation of ICAM-1 and TNF-alpha levels compared to treatment with indomethacin alone (413.66 +- 147.74 pg/mL vs 1106.50 +- 504.22 pg/mL, P = 0.019 and 58.27 +- 67.74 pg/mL vs 230.92 +- 114.47 pg/mL, P = 0.013 respectively).	Curcumin	18-26	intercellular adhesion molecule 1	Rattus norvegicus	68-74
22509079-15	2012	CONCLUSION: The results indicate that curcumin prevents indomethacin-induced gastropathy through the improvement of gastric microcirculation by attenuating the level of ICAM-1 and TNF-alpha.	Curcumin	38-46	intercellular adhesion molecule 1	Rattus norvegicus	169-175
22696871-0	2012	The protective effect of curcumin on Abeta induced aberrant cell cycle reentry on primary cultured rat cortical neurons.	Curcumin	25-33	amyloid beta precursor protein	Rattus norvegicus	37-42
22696871-5	2012	In this study, we first observed the protective action of curcumin on Abeta-induced neuron damage, and then investigated whether this protective effect was a result of the inhibition of cell cycle advance.	Curcumin	58-66	amyloid beta precursor protein	Rattus norvegicus	70-75
22696871-6	2012	MATERIALS AND METHODS: We used MTT assay and TUNEL assay to observe the effect of curcumin on Abeta-induced neuron death, and then examined the activated caspase-3 protein level to further confirm the protective effect of curcumin against Abeta-induced neuron toxicity.	Curcumin	82-90	amyloid beta precursor protein	Rattus norvegicus	94-99
22696871-7	2012	Next, we further investigate whether the inhibition of cell cycle reentry was mediated by the therapeutic effect of curcumin on Abeta induced primary cultured neuron damage by Brdu label assay and western blot assay.	Curcumin	116-124	amyloid beta precursor protein	Rattus norvegicus	128-133
22696871-10	2012	CONCLUSIONS: All the results suggest that curcumin has a protective effect against Abeta-induced toxicity in cultured rat cortical neurons, the inhibition of cell cycle re-entry at least partly mediating the therapeutic effect of curcumin in the AD model in vitro.	Curcumin	42-50	amyloid beta precursor protein	Rattus norvegicus	83-88
22696871-10	2012	CONCLUSIONS: All the results suggest that curcumin has a protective effect against Abeta-induced toxicity in cultured rat cortical neurons, the inhibition of cell cycle re-entry at least partly mediating the therapeutic effect of curcumin in the AD model in vitro.	Curcumin	230-238	amyloid beta precursor protein	Rattus norvegicus	83-88
21497497-11	2012	Curcumin reduced the increased protein levels of Smac/DIABLO induced by immobilization and enhanced the elevation of X-linked inhibitory apoptotic protein levels at R10.	Curcumin	0-8	diablo, IAP-binding mitochondrial protein	Rattus norvegicus	49-53
21497497-11	2012	Curcumin reduced the increased protein levels of Smac/DIABLO induced by immobilization and enhanced the elevation of X-linked inhibitory apoptotic protein levels at R10.	Curcumin	0-8	diablo, IAP-binding mitochondrial protein	Rattus norvegicus	54-60
22144489-8	2012	Dietary administration of 6% pectin or 4% curcumin in C. rodentium-infected mice also inhibited NF-kappaB activity and blocked CD3, F4/80, IL-1alpha/beta, G-CSF/MCP-1/KC, and MPO activity in the CLP while not affecting NF-kappaB activity in the crypts.	Curcumin	42-50	adhesion G protein-coupled receptor E1	Mus musculus	132-137
22144489-8	2012	Dietary administration of 6% pectin or 4% curcumin in C. rodentium-infected mice also inhibited NF-kappaB activity and blocked CD3, F4/80, IL-1alpha/beta, G-CSF/MCP-1/KC, and MPO activity in the CLP while not affecting NF-kappaB activity in the crypts.	Curcumin	42-50	chemokine (C-C motif) ligand 2	Mus musculus	161-169
22144489-8	2012	Dietary administration of 6% pectin or 4% curcumin in C. rodentium-infected mice also inhibited NF-kappaB activity and blocked CD3, F4/80, IL-1alpha/beta, G-CSF/MCP-1/KC, and MPO activity in the CLP while not affecting NF-kappaB activity in the crypts.	Curcumin	42-50	myeloperoxidase	Mus musculus	175-178
21993423-6	2012	Then curcumin decrease RasGRF1 protein expression in malignant cell lines.	Curcumin	5-13	Ras protein specific guanine nucleotide releasing factor 1	Homo sapiens	23-30
26199609-3	2015	Using a Fura-2/AM calcium ion probe, we found that curcumin resisted the effects of the gp120 V3 loop on hippocampal synaptosomes and decreased Ca(2+) concentration in synaptosomes.	Curcumin	51-59	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	88-93
21584871-6	2012	The results showed that the melanin content and tyrosinase activity, as well as the expression of melanogenesis-related proteins in human melanocytes, were significantly inhibited by curcumin in a dose dependent manner.	Curcumin	183-191	tyrosinase	Homo sapiens	48-58
22038826-6	2012	Acutely, curcumin inhibited Stat1 binding to the GAS cis-element, prevented Stat1 nuclear translocation, and reduced Jak1 phosphorylation and phosphorylation of Stat1 at Tyr(701).	Curcumin	9-17	signal transducer and activator of transcription 1	Homo sapiens	28-33
22038826-6	2012	Acutely, curcumin inhibited Stat1 binding to the GAS cis-element, prevented Stat1 nuclear translocation, and reduced Jak1 phosphorylation and phosphorylation of Stat1 at Tyr(701).	Curcumin	9-17	signal transducer and activator of transcription 1	Homo sapiens	76-81
26199609-4	2015	This effect of curcumin was identical to nimodipine, suggesting that curcumin improved the inhibitory effects of gp120 on synaptic plasticity, ameliorated damage caused to the central nervous system, and might be a potential neuroprotective drug.	Curcumin	15-23	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	113-118
22038826-6	2012	Acutely, curcumin inhibited Stat1 binding to the GAS cis-element, prevented Stat1 nuclear translocation, and reduced Jak1 phosphorylation and phosphorylation of Stat1 at Tyr(701).	Curcumin	9-17	signal transducer and activator of transcription 1	Homo sapiens	76-81
26199609-4	2015	This effect of curcumin was identical to nimodipine, suggesting that curcumin improved the inhibitory effects of gp120 on synaptic plasticity, ameliorated damage caused to the central nervous system, and might be a potential neuroprotective drug.	Curcumin	69-77	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	113-118
25839235-9	2015	Pharmacological inhibition of JNK (SP600125) or curcumin reduced transcriptional up-regulation of acid ceramidase.	Curcumin	48-56	N-acylsphingosine amidohydrolase 1	Homo sapiens	98-113
22687416-0	2012	Biliary excretion of curcumin is mediated by multidrug resistance-associated protein 2.	Curcumin	21-29	ATP binding cassette subfamily C member 2	Rattus norvegicus	45-86
22687416-3	2012	The purpose of the present study was to investigate the contribution of multidrug resistance-associated protein 2 (Mrp2) to the biliary excretion of curcumin using Sprague-Dawley rats (SDR) and Eisai hyperbilirubinemic rats (EHBR).	Curcumin	149-157	ATP binding cassette subfamily C member 2	Rattus norvegicus	72-113
22687416-3	2012	The purpose of the present study was to investigate the contribution of multidrug resistance-associated protein 2 (Mrp2) to the biliary excretion of curcumin using Sprague-Dawley rats (SDR) and Eisai hyperbilirubinemic rats (EHBR).	Curcumin	149-157	ATP binding cassette subfamily C member 2	Rattus norvegicus	115-119
22687416-7	2012	These results provide the first evidence that Mrp2 mediates the biliary excretion of curcumin and thus may be a major factor in the control of exposure of curcumin to the bile duct.	Curcumin	85-93	ATP binding cassette subfamily C member 2	Rattus norvegicus	46-50
22687416-7	2012	These results provide the first evidence that Mrp2 mediates the biliary excretion of curcumin and thus may be a major factor in the control of exposure of curcumin to the bile duct.	Curcumin	155-163	ATP binding cassette subfamily C member 2	Rattus norvegicus	46-50
22687416-8	2012	This study may be helpful to the potential use of curcumin as a treatment for bile duct cancer, and to understanding the genetic polymorphism of Mrp2 for clinical trials of curcumin.	Curcumin	173-181	ATP binding cassette subfamily C member 2	Rattus norvegicus	145-149
25996685-0	2015	Gelsolin Amyloidogenesis Is Effectively Modulated by Curcumin and Emetine Conjugated PLGA Nanoparticles.	Curcumin	53-61	gelsolin	Homo sapiens	0-8
23275729-8	2012	The natural molecules curcumin, epigallocatechin gallate (EGCG), barrigtozenol and finasteride were showing reliable interaction with VEGFR and their pharmacokinetics parameters were comparatively good than the pazopanib.	Curcumin	22-30	kinase insert domain receptor	Homo sapiens	134-139
22138522-0	2012	Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression.	Curcumin	0-8	toll-like receptor 9	Mus musculus	118-122
22138522-7	2012	Furthermore, the expression levels of Toll-like receptor (TLR) 2, TLR4 and TLR9 mRNA or protein in liver tissues were significantly lowered by curcumin treatment.	Curcumin	143-151	toll-like receptor 9	Mus musculus	75-79
25938910-6	2015	Rather, curcumin blocked autoacylation of the palmitoyl acyltransferase DHHC3 that is responsible for ITG beta4 palmitoylation.	Curcumin	8-16	zinc finger DHHC-type palmitoyltransferase 3	Homo sapiens	72-77
22138522-10	2012	The beneficial effect of curcumin may be partly mediated by inhibiting the expression levels of TLR2, TLR4 and TLR9 in the liver.	Curcumin	25-33	toll-like receptor 9	Mus musculus	111-115
25374685-0	2012	In Silico Inhibition Studies of Jun-Fos-DNA Complex Formation by Curcumin Derivatives.	Curcumin	65-73	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	36-39
25891083-13	2015	CONCLUSION: Curcumin inhibits appoptosin-induced apoptosis in SH-SY5Y cells by upregulating the expression of HO-1, reducing the production of intracellular heme and ROS, and preventing the DeltaPsim loss.	Curcumin	12-20	heme oxygenase 1	Homo sapiens	110-114
25374685-6	2012	The present in silico study provides insights into the inhibition of Jun-Fos-DNA complex formation by curcumin derivatives.	Curcumin	102-110	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-76
22888245-0	2012	Preparation and in vivo pharmacokinetics of curcumin-loaded PCL-PEG-PCL triblock copolymeric nanoparticles.	Curcumin	44-52	PHD finger protein 1	Homo sapiens	60-63
25583641-7	2015	Further, the expression of two important cell cycle inhibitory proteins, p21 and p53, in the curcumin- and culture medium-treated cells without curcumin was evaluated by intracellular flow cytometry.	Curcumin	93-101	H3 histone pseudogene 16	Homo sapiens	73-76
22888245-0	2012	Preparation and in vivo pharmacokinetics of curcumin-loaded PCL-PEG-PCL triblock copolymeric nanoparticles.	Curcumin	44-52	PHD finger protein 1	Homo sapiens	68-71
29490624-10	2018	In the presence of UCP2 inhibitor genipin, both curcumin-mediated decrease of ROS and increase of NO production were blocked.	Curcumin	48-56	uncoupling protein 2	Rattus norvegicus	19-23
29490624-11	2018	CONCLUSION: Our study suggests that curcumin exerts a stroke preventive effect by attenuating oxidative stress to improve vascular endothelial function, which might be associated with UCP2 signaling.	Curcumin	36-44	uncoupling protein 2	Rattus norvegicus	184-188
29599831-0	2018	Effect of curcumin on vascular endothelial growth factor in hypoxic HepG2 cells via the insulin-like growth factor 1 receptor signaling pathway.	Curcumin	10-18	insulin like growth factor 1 receptor	Homo sapiens	88-125
22942754-6	2012	These results show that curcumin-mediated inhibition of glutamate release involves modulating downstream events by controlling synaptic vesicle recruitment and exocytosis, possibly through a decrease of MAPK/ERK activation and synapsin I phosphorylation, thereby decreasing synaptic vesicle availability for exocytosis.	Curcumin	24-32	synapsin I	Rattus norvegicus	227-237
25583641-10	2015	Flow cytometry analysis showed a twofold increase in the expression of both p21 and p53 in curcumin-treated cells as compared to the medium-treated cells, suggesting that curcumin inhibits EPC growth by mainly inhibiting the G1 to S phase transition in the cell cycle.	Curcumin	91-99	H3 histone pseudogene 16	Homo sapiens	76-79
25583641-10	2015	Flow cytometry analysis showed a twofold increase in the expression of both p21 and p53 in curcumin-treated cells as compared to the medium-treated cells, suggesting that curcumin inhibits EPC growth by mainly inhibiting the G1 to S phase transition in the cell cycle.	Curcumin	171-179	H3 histone pseudogene 16	Homo sapiens	76-79
21891973-9	2012	In the AD brain, NFTs positive for PHF-tau and Gallyas silver were moderately stained with curcumin.	Curcumin	91-99	microtubule-associated protein tau	Mus musculus	35-42
25510836-9	2015	The administration of curcumin at 100 mg/kg during the 12 weeks markedly decreased the expression of PCNA, Bcl-2, SOCS1 e -3, and STAT3.	Curcumin	22-30	signal transducer and activator of transcription 3	Rattus norvegicus	130-135
21874542-3	2012	We found that curcumin caused lysosomal membrane permeabilization (LMP) and cytosolic relocation of cathepsin B (cath B) and cathepsin D (cath D).	Curcumin	14-22	cathepsin B	Homo sapiens	100-111
21874542-3	2012	We found that curcumin caused lysosomal membrane permeabilization (LMP) and cytosolic relocation of cathepsin B (cath B) and cathepsin D (cath D).	Curcumin	14-22	cathepsin B	Homo sapiens	113-119
29440765-8	2018	In addition to baicalin treatment, we found that the hypoxia-response protein DEPP functions as a positive regulator involving the regulations of Ras/Raf/MEK/ERK signaling pathway and inhibition of human colon cancer by other anti-oxidative drugs, such as curcumin and sulforaphane, resulting in tumor cellular senescence.	Curcumin	256-264	DEPP1 autophagy regulator	Homo sapiens	78-82
28902433-0	2018	Curcumin alleviates IL-17A-mediated p53-PAI-1 expression in bleomycin-induced alveolar basal epithelial cells.	Curcumin	0-8	interleukin 17A	Homo sapiens	20-26
29303982-0	2018	Curcumin Analog DK1 Induces Apoptosis in Human Osteosarcoma Cells In Vitro through Mitochondria-Dependent Signaling Pathway.	Curcumin	0-8	immunoglobulin heavy diversity 5-12	Homo sapiens	16-19
25746281-0	2015	Study on the interactions of trans-resveratrol and curcumin with bovine alpha-lactalbumin by spectroscopic analysis and molecular docking.	Curcumin	51-59	lactalbumin alpha	Bos taurus	72-89
29303982-5	2018	In this study, the cytotoxic effects of the curcumin analog DK1 was investigated in both U-2OS and MG-63 osteosarcoma cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and cell death was microscopically examined via acridine orange/propidium iodide (AO/PI) double staining.	Curcumin	44-52	immunoglobulin heavy diversity 5-12	Homo sapiens	60-63
29301315-9	2018	Curcumin inhibits cytochrome P450 isoenzymes, particularly CYP2A6 isoform; thereby reducing the formation of AFB1-8, 9-epoxide and other toxic metabolites causing aflatoxicosis.	Curcumin	0-8	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	59-65
25746281-1	2015	The ability of bovine alpha-lactalbumin (BLA) as a whey protein to carry curcumin and trans-resveratrol as two natural polyphenolic compounds was investigated by fluorescence quenching measurements and docking studies.	Curcumin	73-81	lactalbumin alpha	Bos taurus	22-39
25786779-5	2015	By entrapping in apoferritin both Gd-HPDO3A and curcumin, it was possible to deliver a therapeutic dose of 167 mug ml(-1) (as calculated by MRI) of this natural drug to MCF-7 cells, thus obtaining a significant reduction of cell proliferation.	Curcumin	48-56	ferritin heavy chain 1	Homo sapiens	17-28
29239219-0	2018	Multifunctional redox-responsive and CD44 receptor targeting polymer-drug nanomedicine based curcumin and alendronate: synthesis, characterization and in vitro evaluation.	Curcumin	93-101	CD44 molecule (Indian blood group)	Homo sapiens	37-41
28561324-7	2018	Curcumin further reduced adenine-induced hypertension, urinary albumin, the inflammatory cytokines IL-1beta, IL-6 and TNF-alpha, cystatin C and adiponectin.	Curcumin	0-8	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	144-155
29089332-7	2018	Sequencing of the Ras family genes (KRAS, NRAS, and HRAS) revealed less frequent KRAS and HRAS mutations in ovarian tumors in the curcumin-fed animals.	Curcumin	130-138	neuroblastoma RAS viral oncogene homolog	Gallus gallus	42-46
25860911-0	2015	Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of inflammation in prevention of cancer.	Curcumin	20-28	transformation related protein 53, pseudogene	Mus musculus	65-68
25860911-3	2015	Present study was designed to investigate long term effect of curcumin in regulation of Nrf2 mediated phase-II antioxidant enzymes, tumour suppressor p53 and inflammation under oxidative tumour microenvironment in liver of T-cell lymphoma bearing mice.	Curcumin	62-70	transformation related protein 53, pseudogene	Mus musculus	150-153
25860911-8	2015	The study suggests that during long term effect, curcumin leads to prevention of cancer by inducing phase-II antioxidant enzymes via activation of Nrf2 signalling, restoration of tumour suppressor p53 and modulation of inflammatory mediators like iNOS and COX2 in liver of lymphoma bearing mice.	Curcumin	49-57	transformation related protein 53, pseudogene	Mus musculus	197-200
29788875-4	2018	In fact, it has been found that curcumin can sensitize NPC cells to radiation through different mechanisms, including modulation of ROS generation, Jab1/CSN5 and non-coding RNAs.	Curcumin	32-40	COP9 signalosome subunit 5	Homo sapiens	148-157
24517573-0	2015	Inhibitory effects of curcumin on activity of cytochrome P450 2C9 enzyme in human and 2C11 in rat liver microsomes.	Curcumin	22-30	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	46-65
29463371-1	2018	In this paper, a novel pH and redox dual-sensitive nanocarrier loaded with curcumin (Cur) and anticancer polypeptide (AP) was developed for dual targeting mitochondrial and CD44 receptor.	Curcumin	75-83	CD44 molecule (Indian blood group)	Homo sapiens	173-177
24517573-3	2015	The objective of this work was to investigate the effects of curcumin on CYP2C9 in human and cytochrome P450 2C11 (CYP2C11) in rat liver microsomes.	Curcumin	61-69	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	73-79
24517573-4	2015	The results showed that curcumin inhibited CYP2C9 activity (10 micromol L(-1) diclofenac) with half-maximal inhibition or a half-maximal inhibitory concentration (IC50) of 15.25 micromol L(-1) and Ki = 4.473 micromol L(-1) in human liver microsomes.	Curcumin	24-32	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	43-49
29354231-8	2018	The GFAP immunoreactivity of the SCI-curcumin group was remarkably lower than that of the SCI-vehicle group 4 weeks after surgery (p&lt;0.05).	Curcumin	37-45	glial fibrillary acidic protein	Rattus norvegicus	4-8
27966075-10	2018	Modulation in the expression of BDNF and pGSK3beta in corpus striatum by curcumin exhibits the importance of neuronal survival pathway in arsenic-induced dopaminergic dysfunctions.	Curcumin	73-81	brain-derived neurotrophic factor	Rattus norvegicus	32-36
27966075-12	2018	The results exhibit that curcumin modulates BDNF/DARPP32/CREB in arsenic-induced alterations in dopaminergic signaling in rat corpus striatum.	Curcumin	25-33	brain-derived neurotrophic factor	Rattus norvegicus	44-48
24517573-5	2015	Curcumin"s mode of action on CYP2C9 activity was noncompetitive for the substrate diclofenanc and uncompetitive for the cofactor NADPH.	Curcumin	0-8	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	29-35
24517573-7	2015	The observations imply that curcumin has the inhibitory effects on CYP2C9 activity in human.	Curcumin	28-36	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	67-73
25644785-6	2015	Diclofenac and Curcumin administration significantly increased the expression of pro-apoptotic Bcl-2 family members (Bad and Bax) while decreasing the anti-apoptotic Bcl-2 protein.	Curcumin	15-23	BCL2 associated X, apoptosis regulator	Rattus norvegicus	125-128
25712644-9	2015	Various dosage of Curcumin attenuated these effects by significantly lowering lipid peroxidation, GSSG level, Bax concentration, caspase-3 and caspase-9 activities, while increasing superoxide dismutase and glutathione peroxidase activity, GSH level and Bcl-2 concentration.	Curcumin	18-26	BCL2 associated X, apoptosis regulator	Rattus norvegicus	110-113
25742310-0	2015	Curcumin analog DM-1 in monotherapy or combinatory treatment with dacarbazine as a strategy to inhibit in vivo melanoma progression.	Curcumin	0-8	immunoglobulin heavy diversity 1-7	Homo sapiens	16-20
29285195-0	2018	14-3-3epsilon is a nuclear matrix protein, and its altered expression and localization are associated with curcumin-induced apoptosis of MG-63 cells.	Curcumin	107-115	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	0-13
29285195-5	2018	Analysis of nuclear matrix proteins (NMPs), using two-dimensional gel electrophoresis with matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry, revealed that 14-3-3epsilon existed on the nuclear matrix of MG-63 cells, and its expression was decreased compared with that in control cells following curcumin treatment.	Curcumin	322-330	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	183-196
29285195-6	2018	In addition, western blot analysis validated that the expression level of 14-3-3epsilon was downregulated during curcumin-induced apoptosis of MG-63 cells compared with that in control cells.	Curcumin	113-121	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	74-87
29285195-7	2018	Using immunofluorescence labeling, it was observed that 14-3-3epsilon was located on the nuclear matrix of MG-63 cells and the distribution of 14-3-3epsilon on the nuclear matrix was decreased following treatment with curcumin, compared with that in control cells.	Curcumin	218-226	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	56-69
29285195-7	2018	Using immunofluorescence labeling, it was observed that 14-3-3epsilon was located on the nuclear matrix of MG-63 cells and the distribution of 14-3-3epsilon on the nuclear matrix was decreased following treatment with curcumin, compared with that in control cells.	Curcumin	218-226	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	143-156
25742310-3	2015	DM-1 is a sodium phenolate and curcumin analog with proven anticancer, anti-proliferative and anti-metastatic properties.	Curcumin	31-39	immunoglobulin heavy diversity 1-7	Homo sapiens	0-4
29273065-10	2017	The chemosensitizing role of curcumin might attribute to the autophagy turnover from being activated in 5-Fu mono-treatment to being inhibited in the pre-Cur treatment as indicated by the changes in expression of beclin-1, p62 and LC3II/LC3I and the intensity of Cyto-ID Green staining.	Curcumin	29-37	beclin 1	Homo sapiens	213-221
25573684-6	2015	SCC cell lines are treated with curcumin to regulate PIAS3 expression and cell growth.	Curcumin	32-40	serpin family B member 3	Homo sapiens	0-3
29273065-10	2017	The chemosensitizing role of curcumin might attribute to the autophagy turnover from being activated in 5-Fu mono-treatment to being inhibited in the pre-Cur treatment as indicated by the changes in expression of beclin-1, p62 and LC3II/LC3I and the intensity of Cyto-ID Green staining.	Curcumin	29-37	nucleoporin 62	Homo sapiens	223-226
29162665-18	2017	Curcumin also attenuated splanchnic hyperdynamic circulation by inducing vasoconstriction through inhibition of eNOS activation and by decreasing mesenteric angiogenesis via VEGF pathway blockade.	Curcumin	0-8	nitric oxide synthase 3	Rattus norvegicus	112-116
29180881-7	2017	Further, curcumin and ACNU acted synergistically in their antitumor effects by targeting N-cadherin/MMP2/9, PI3K/AKT, and NF-kappaB/COX-2 signaling.	Curcumin	9-17	cadherin 2	Homo sapiens	89-99
25573684-9	2015	Curcumin treatment increased endogenous PIAS3 expression and decreased cell growth and viability in Calu-1 cells, a model of SCC.	Curcumin	0-8	serpin family B member 3	Homo sapiens	125-128
25578635-0	2015	Curcumin inhibits proliferation-migration of NSCLC by steering crosstalk between a Wnt signaling pathway and an adherens junction via EGR-1.	Curcumin	0-8	early growth response 1	Homo sapiens	134-139
29039788-10	2017	Several of these compounds (e.g., reseveratol and curcumin) act by inhibiting the activity or expression of DNA methyltransferases and reactive RASSF1A in cancer.	Curcumin	50-58	Ras association domain family member 1	Homo sapiens	144-151
28849007-0	2017	Curcumin prevents reperfusion injury following ischemic stroke in rats via inhibition of NF-kappaB, ICAM-1, MMP-9 and caspase-3 expression.	Curcumin	0-8	intercellular adhesion molecule 1	Rattus norvegicus	100-106
28849007-0	2017	Curcumin prevents reperfusion injury following ischemic stroke in rats via inhibition of NF-kappaB, ICAM-1, MMP-9 and caspase-3 expression.	Curcumin	0-8	matrix metallopeptidase 9	Rattus norvegicus	108-113
25578635-10	2015	This hypothesis was validated by in vitro experiments: EGR-1 was decreased after curcumin treatment.	Curcumin	81-89	early growth response 1	Homo sapiens	55-60
28849007-8	2017	The findings revealed that inflammation (NF-kappaB, ICAM-1 and MMP-9) and apoptosis (caspase-3)-related markers were significantly downregulated in the curcumin-treated MCAO group compared with the vehicle-treated MCAO group.	Curcumin	152-160	intercellular adhesion molecule 1	Rattus norvegicus	52-58
28849007-8	2017	The findings revealed that inflammation (NF-kappaB, ICAM-1 and MMP-9) and apoptosis (caspase-3)-related markers were significantly downregulated in the curcumin-treated MCAO group compared with the vehicle-treated MCAO group.	Curcumin	152-160	matrix metallopeptidase 9	Rattus norvegicus	63-68
25578635-11	2015	Curcumin exhibited a significant anti-proliferation and anti-migration activity in NSCLC 95D cells, possibly by steering the crosstalk between the Wnt signaling pathway and adherens junction via EGR-1.	Curcumin	0-8	early growth response 1	Homo sapiens	195-200
28608236-0	2017	The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB-BDNF Signaling Pathway.	Curcumin	30-38	brain-derived neurotrophic factor	Rattus norvegicus	98-102
25497868-7	2015	Treatment with UBS109, EF31 or curcumin inhibited HSP90, NF-kappaB, and HIF-1alpha transcription in PC cell lines.	Curcumin	31-39	heat shock protein 90 alpha family class A member 1	Homo sapiens	50-55
28608236-3	2017	The current study was designed to evaluate the role of CREB-BDNF signaling in mediating the neuroprotective effects of curcumin against nicotine-induced apoptosis, oxidative stress and inflammation in rats.	Curcumin	119-127	brain-derived neurotrophic factor	Rattus norvegicus	60-64
28806703-7	2017	Augmentation of proteasome activity was related to the up-regulation of proteasome subunit alpha 5 (PSMA5) expression in curcumin plus thioridazine-treated cells.	Curcumin	121-129	proteasome 20S subunit alpha 5	Homo sapiens	72-98
25497868-9	2015	Finally, we demonstrate for the first time that curcumin analogues EF31 and UBS109 induce the downregulation of HIF-1alpha, Hsp90, COX-2 and VEGF in tumor samples from xenograft models compared to untreated xenografts.	Curcumin	48-56	heat shock protein 90 alpha family class A member 1	Homo sapiens	124-129
25474544-5	2015	Curcumin increased the expression of glucose transporter 2 (GLUT2) and phosphorylation of insulin receptor (IR), insulin receptor substrate-1 (IRS1), phosphatidylinositol-3-kinase (PI3K) and AKT in the INS-1 cells.	Curcumin	0-8	solute carrier family 2 member 2	Rattus norvegicus	37-58
28806703-7	2017	Augmentation of proteasome activity was related to the up-regulation of proteasome subunit alpha 5 (PSMA5) expression in curcumin plus thioridazine-treated cells.	Curcumin	121-129	proteasome 20S subunit alpha 5	Homo sapiens	100-105
25474544-5	2015	Curcumin increased the expression of glucose transporter 2 (GLUT2) and phosphorylation of insulin receptor (IR), insulin receptor substrate-1 (IRS1), phosphatidylinositol-3-kinase (PI3K) and AKT in the INS-1 cells.	Curcumin	0-8	solute carrier family 2 member 2	Rattus norvegicus	60-65
28806703-8	2017	Combined treatment with curcumin and thioridazine produced intracellular ROS in a NOX4-dependent manner, and ROS-mediated activation of Nrf2/ARE signaling played a critical role in the up-regulation of PSMA5 expression.	Curcumin	24-32	proteasome 20S subunit alpha 5	Homo sapiens	202-207
21964250-7	2012	Our data have suggested that 17-AAG and curcumin are effective in vitro in both rescuing the nuclear localization and transactivation activity of PHOX2B carrying the largest expansion of polyAla and promoting the clearance of aggregates of these mutant proteins inducing molecular mechanisms such as ubiquitin-proteasome (UPS), autophagy and heat shock protein (HSP) systems.	Curcumin	40-48	paired like homeobox 2B	Homo sapiens	146-152
28806703-10	2017	Therefore, we demonstrated that thioridazine plus curcumin induces proteasome activity by up-regulating PSMA5 expression via NOX4-mediated ROS production and that down-regulation of c-FLIP and Mcl-1 expression post-translationally is involved in apoptosis.	Curcumin	50-58	proteasome 20S subunit alpha 5	Homo sapiens	104-109
21964250-7	2012	Our data have suggested that 17-AAG and curcumin are effective in vitro in both rescuing the nuclear localization and transactivation activity of PHOX2B carrying the largest expansion of polyAla and promoting the clearance of aggregates of these mutant proteins inducing molecular mechanisms such as ubiquitin-proteasome (UPS), autophagy and heat shock protein (HSP) systems.	Curcumin	40-48	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	342-360
25474544-7	2015	This investigation suggests that curcumin prevented high glucose-reduced insulin expression and secretion through activation of the PI3K/Akt/GLUT2 pathway in INS-1 cells.	Curcumin	33-41	solute carrier family 2 member 2	Rattus norvegicus	141-146
21964250-7	2012	Our data have suggested that 17-AAG and curcumin are effective in vitro in both rescuing the nuclear localization and transactivation activity of PHOX2B carrying the largest expansion of polyAla and promoting the clearance of aggregates of these mutant proteins inducing molecular mechanisms such as ubiquitin-proteasome (UPS), autophagy and heat shock protein (HSP) systems.	Curcumin	40-48	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	362-365
24807589-11	2015	These results suggested that curcumin exerts the effects on IBS through regulating neurotransmitters, BDNF and CREB signaling both in the brain and peripheral intestinal system.	Curcumin	29-37	cAMP responsive element binding protein 1	Rattus norvegicus	111-115
23285282-11	2012	VEGF mainly expressed in F4/80 positive macrophages in laser injury sites, which was suppressed by curcumin treatment (P&lt;0.01).	Curcumin	99-107	adhesion G protein-coupled receptor E1	Mus musculus	25-30
23285282-12	2012	Curcumin inhibited the RPE-choroid levels of TNF-alpha (P&lt;0.05), MCP-1 (P&lt;0.05) and ICAM-1 (P&lt;0.05), and suppressed the activation of NF-kappaB in nuclear extracts (P&lt;0.05) and the activation of HIF-1alpha (P&lt;0.05).	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	68-73
21887696-6	2011	Curcumin also promoted the releases of AIF and Endo G from the mitochondria in SCC-4 cells by using confocal laser microscope.	Curcumin	0-8	endonuclease G	Homo sapiens	47-53
21748336-0	2011	Curcumin promotes cholesterol efflux from adipocytes related to PPARgamma-LXRalpha-ABCA1 passway.	Curcumin	0-8	oxysterols receptor LXR-alpha	Oryctolagus cuniculus	74-82
21748336-0	2011	Curcumin promotes cholesterol efflux from adipocytes related to PPARgamma-LXRalpha-ABCA1 passway.	Curcumin	0-8	ATP-binding cassette sub-family A member 1	Oryctolagus cuniculus	83-88
29072221-0	2017	Comparative evaluation of inhibitory effect of curcumin and doxycycline on matrix metalloproteinase-9 activity in chronic periodontitis.	Curcumin	47-55	matrix metallopeptidase 9	Homo sapiens	75-101
29072221-3	2017	Curcumin has anti-inflammatory effect and also downregulates MMP activity.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	61-64
29072221-4	2017	Thus, a study was conducted to evaluate the anti-inflammatory effect of curcumin by its inhibition of MMP-9 activity and compare the same with doxcycline, which has known anticollagenase activity.	Curcumin	72-80	matrix metallopeptidase 9	Homo sapiens	102-107
29072221-10	2017	Curcumin showed 61.01% reduction in the MMP-9 activity at 1500 mug/ml concentration and doxycycline showed 59.58% reduction in the MMP-9 activity at 300 mug/ml concentration.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	40-45
29072221-11	2017	CONCLUSION: The current study showed that curcumin has inhibitory effect on polymorphonuclear leukocyte-type MMP-9 involved in matrix degradation in periodontitis.	Curcumin	42-50	matrix metallopeptidase 9	Homo sapiens	109-114
21748336-5	2011	The increased expression of PPARgamma, LXRalpha and ABCA1 caused by curcumin were parallel.	Curcumin	68-76	oxysterols receptor LXR-alpha	Oryctolagus cuniculus	39-47
21748336-5	2011	The increased expression of PPARgamma, LXRalpha and ABCA1 caused by curcumin were parallel.	Curcumin	68-76	ATP-binding cassette sub-family A member 1	Oryctolagus cuniculus	52-57
26163620-6	2015	On the contrary, HCC groups treated with either curcumin or carvacrol showed significant downregulation in AR and ERalpha gene expression levels in the liver tissue.	Curcumin	48-56	estrogen receptor 1	Rattus norvegicus	114-121
21748336-6	2011	When the adipocytes were pre-treated by GW9662, the increased expression of PPARgamma induced by curcumin was partially prevented, subsequent to the down-regulation of LXRalpha and ABCA1.	Curcumin	97-105	ATP-binding cassette sub-family A member 1	Oryctolagus cuniculus	181-186
21748336-7	2011	Curcumin can affect the cholesterol efflux from adipocytes by regulating the PPARgamma-LXR-ABCA1 passway.	Curcumin	0-8	ATP-binding cassette sub-family A member 1	Oryctolagus cuniculus	91-96
22058071-9	2011	Hepatic complement factor D (Cfd) and systemic CRP levels, markers of immune complement pathway activation, were significantly reduced by curcumin treatment.	Curcumin	138-146	C-reactive protein, pentraxin-related	Mus musculus	47-50
21821729-2	2011	Curcumin has potent antioxidant and anti-inflammatory properties, and it modulates signaling of peroxisome proliferator-activated receptor-gamma (PPARgamma), an important molecule in the pathobiology of BPD.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	96-144
21821729-2	2011	Curcumin has potent antioxidant and anti-inflammatory properties, and it modulates signaling of peroxisome proliferator-activated receptor-gamma (PPARgamma), an important molecule in the pathobiology of BPD.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	146-155
21821729-6	2011	Curcumin dose dependently accelerated e19 fibroblast differentiation [increased parathyroid hormone-related protein (PTHrP) receptor, PPARgamma, and adipocyte differentiation-related protein (ADRP) levels and triolein uptake] and proliferation (increased thymidine incorporation).	Curcumin	0-8	parathyroid hormone-like hormone	Rattus norvegicus	80-115
21821729-6	2011	Curcumin dose dependently accelerated e19 fibroblast differentiation [increased parathyroid hormone-related protein (PTHrP) receptor, PPARgamma, and adipocyte differentiation-related protein (ADRP) levels and triolein uptake] and proliferation (increased thymidine incorporation).	Curcumin	0-8	parathyroid hormone-like hormone	Rattus norvegicus	117-122
21821729-6	2011	Curcumin dose dependently accelerated e19 fibroblast differentiation [increased parathyroid hormone-related protein (PTHrP) receptor, PPARgamma, and adipocyte differentiation-related protein (ADRP) levels and triolein uptake] and proliferation (increased thymidine incorporation).	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	134-143
21821729-7	2011	Pretreatment with curcumin blocked the hyperoxia-induced decrease (PPARgamma and ADRP) and increase (alpha-smooth muscle actin and fibronectin) in markers of lung injury/repair, as well as the activation of TGF-beta signaling.	Curcumin	18-26	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	67-76
28860665-9	2017	The results showed that curcumin exerts renoprotective effects by inhibiting oxidative stress in rhabdomyolysis-induced AKI through regulation of the AMPK and Nrf2/HO-1 signaling pathways, and also ameliorated RM-associated renal injury and cell apoptosis by activating the PI3K/Akt pathway.	Curcumin	24-32	heme oxygenase 1	Rattus norvegicus	164-168
29245915-4	2017	Sildenafil and curcumin reduced mTORC1 and mTORC2 activity and increased Beclin1 levels and the numbers of autophagosomes and autolysosomes in cells in a PERK-eIF2alpha-dependent fashion.	Curcumin	15-23	beclin 1	Homo sapiens	73-80
29245915-4	2017	Sildenafil and curcumin reduced mTORC1 and mTORC2 activity and increased Beclin1 levels and the numbers of autophagosomes and autolysosomes in cells in a PERK-eIF2alpha-dependent fashion.	Curcumin	15-23	eukaryotic translation initiation factor 2A	Homo sapiens	159-168
29245915-7	2017	Curcumin and sildenafil exposure reduced the expression of MCL-1, BCL-XL, thioredoxin and superoxide dismutase 2 (SOD2) in an eIF2alpha-dependent fashion.	Curcumin	0-8	eukaryotic translation initiation factor 2A	Homo sapiens	126-135
28622711-11	2017	In vitro, curcumin could accelerate cell autophagy through regulating autophagy related Erk1/2 and Akt pathway, prevent cell apoptosis and promote expression of PMP22 and S100, and reduced deposition of Fibrin in cultured RSC96 SCs.	Curcumin	10-18	peripheral myelin protein 22	Rattus norvegicus	161-166
21903608-3	2011	We investigated the effect of curcumin (diferuloylmethane), a molecule with anti-inflammatory and antitumorigenic properties, on human schwannoma cell growth and the regulation of merlin by curcumin in both NF2 cells and neuroblastoma (non-NF2) cells.	Curcumin	190-198	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	180-186
21903608-3	2011	We investigated the effect of curcumin (diferuloylmethane), a molecule with anti-inflammatory and antitumorigenic properties, on human schwannoma cell growth and the regulation of merlin by curcumin in both NF2 cells and neuroblastoma (non-NF2) cells.	Curcumin	190-198	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	207-210
25517601-10	2015	We found that down-regulation of Mcl-1, an essential MM survival factor, was associated with curcumin-induced cell death and its knockdown sensitized myeloma cells to curcumin, highlighting Mcl-1 as an important target for curcumin-induced apoptosis.	Curcumin	93-101	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	33-38
21903608-5	2011	Curcumin also activated MYPT1-pp1delta (a merlin phosphatase), which was associated with dephosphorylation of merlin on serine 518, an event that results in the folding of merlin to its active conformation.	Curcumin	0-8	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	42-48
21903608-5	2011	Curcumin also activated MYPT1-pp1delta (a merlin phosphatase), which was associated with dephosphorylation of merlin on serine 518, an event that results in the folding of merlin to its active conformation.	Curcumin	0-8	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	110-116
21903608-7	2011	Consequently, hsp70 was upregulated at the mRNA and protein levels, possibly serving as a mechanism of escape from curcumin-induced apoptosis and growth inhibition.	Curcumin	115-123	heat shock protein family A (Hsp70) member 4	Homo sapiens	14-19
28781627-0	2017	Curcumin attenuates hypoxic-ischemic brain injury in neonatal rats through induction of nuclear factor erythroid-2-related factor 2 and heme oxygenase-1.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	136-152
28781627-2	2017	In the present study, whether the attenuating effects of curcumin against hypoxic-ischemic brain injury in neonatal rats are mediated via nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) was investigated.	Curcumin	57-65	heme oxygenase 1	Rattus norvegicus	193-209
28781627-2	2017	In the present study, whether the attenuating effects of curcumin against hypoxic-ischemic brain injury in neonatal rats are mediated via nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) was investigated.	Curcumin	57-65	heme oxygenase 1	Rattus norvegicus	211-215
28781627-6	2017	Treatment with curcumin effectively reduced the brain injury score, increased myelin basic protein (MBP) expression and increased the quantity of neuronal cells in neonatal rats with hypoxic-ischemic brain injury.	Curcumin	15-23	myelin basic protein	Rattus norvegicus	78-98
21903608-10	2011	Our results provide a rationale for combining curcumin and KNK437 in the treatment of NF2.	Curcumin	46-54	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	86-89
22045654-0	2011	Curcumin attenuates diabetic nephropathy by inhibiting PKC-alpha and PKC-beta1 activity in streptozotocin-induced type I diabetic rats.	Curcumin	0-8	protein kinase C, alpha	Rattus norvegicus	55-64
28781627-6	2017	Treatment with curcumin effectively reduced the brain injury score, increased myelin basic protein (MBP) expression and increased the quantity of neuronal cells in neonatal rats with hypoxic-ischemic brain injury.	Curcumin	15-23	myelin basic protein	Rattus norvegicus	100-103
25517601-10	2015	We found that down-regulation of Mcl-1, an essential MM survival factor, was associated with curcumin-induced cell death and its knockdown sensitized myeloma cells to curcumin, highlighting Mcl-1 as an important target for curcumin-induced apoptosis.	Curcumin	167-175	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	33-38
28781627-8	2017	Treatment with curcumin significantly increased Nrf2 and HO-1 expression in the neonatal rats with hypoxic-ischemic brain injury.	Curcumin	15-23	heme oxygenase 1	Rattus norvegicus	57-61
22045654-1	2011	SCOPE: We hypothesized that curcumin, a potent anti-oxidant, might be beneficial in ameliorating the development of diabetic nephropathy through inhibition of PKC-alpha and PKC-beta1 activity-ERK1/2 pathway.	Curcumin	28-36	protein kinase C, alpha	Rattus norvegicus	159-168
22045654-6	2011	Furthermore, the high-glucose-induced PKC-alpha and PKC-beta1 activities and phosphorylated ERK1/2 was significantly diminished by curcumin.	Curcumin	131-139	protein kinase C, alpha	Rattus norvegicus	38-47
22045654-9	2011	CONCLUSION: These results prove that curcumin produces dual blockade of both PKC-alpha and PKC-beta1 activities, which suggests that curcumin is a potential adjuvant therapy for the prevention and treatment of diabetic nephropathy.	Curcumin	37-45	protein kinase C, alpha	Rattus norvegicus	77-86
22045654-9	2011	CONCLUSION: These results prove that curcumin produces dual blockade of both PKC-alpha and PKC-beta1 activities, which suggests that curcumin is a potential adjuvant therapy for the prevention and treatment of diabetic nephropathy.	Curcumin	133-141	protein kinase C, alpha	Rattus norvegicus	77-86
22045655-0	2011	Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1.	Curcumin	29-37	phosphodiesterase 1A, calmodulin-dependent	Mus musculus	71-76
22045655-9	2011	Interestingly, PDE1A overexpression increased UHRF1 and DNMT1 expressions and rescued the B16F10 cells from curcumin anti-proliferative effects.	Curcumin	108-116	phosphodiesterase 1A, calmodulin-dependent	Mus musculus	15-20
22045655-11	2011	CONCLUSION: Curcumin exerts its anti-cancer property by targeting PDE1 that inhibits melanoma cell proliferation via UHRF1, DNMT1, cyclin A, p21 and p27 regulations.	Curcumin	12-20	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	141-144
28405735-0	2017	Curcumin inhibits epigen and amphiregulin upregulated by 2,4,6-trinitrochlorobenzene associated with attenuation of skin swelling.	Curcumin	0-8	epithelial mitogen	Mus musculus	18-24
28405735-13	2017	Curcumin also attenuated TNCB-induced ERK phosphorylation and expression of EPGN and AREG genes.	Curcumin	0-8	epithelial mitogen	Mus musculus	76-80
25517601-10	2015	We found that down-regulation of Mcl-1, an essential MM survival factor, was associated with curcumin-induced cell death and its knockdown sensitized myeloma cells to curcumin, highlighting Mcl-1 as an important target for curcumin-induced apoptosis.	Curcumin	167-175	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	33-38
21855605-6	2011	In addition, 7 out of 11 vagal sensory neurons from wild type mice responded to curcumin (30muM) with inward currents (11.6+-5.4pA/pF) that were largely reversed by TRPA1 blockers.	Curcumin	80-88	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	165-170
26053510-7	2015	Curcumin inhibits Abeta-induced increase of cellular Ca(2+) and depresses Abeta-induced phosphorylations of both NMDA receptor and cyclic AMP response element-binding protein (CREB) and activating transcription factor 1 (ATF-1).	Curcumin	0-8	activating transcription factor 1	Homo sapiens	186-219
21519785-6	2011	In addition, curcumin significantly inactivated p38 mitogen-activated protein kinases (MAPK) and stress-activated protein kinase/c-Jun N-terminal kinases (SARK/JNK), coupled with inhibition of p53 and p21 tumor suppressor gene products.	Curcumin	13-21	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	201-204
22362715-7	2011	Curcumin down-regulated the expression of cluster of differntiation (CD)147, matrix metalloproteinase 2, and matrix metalloproteinase 9 and inhibited the phosphorylation of epidermal growth factor receptor (EGFR), the phosphoinositilde 3-kinase (PI3K)/protein kinase B (Akt), p38 mitogen-activated protein kinase (MAPK), and p44/42MAPK in Hca-F cells.	Curcumin	0-8	matrix metallopeptidase 2	Mus musculus	77-103
28286973-3	2017	Curcumin inhibits IGF2 expression at the transcriptional level and decreases the phosphorylation levels of IGF1R and IRS-1 in bladder cancer cells and N-methyl-N-nitrosourea (MNU)-induced urothelial tumor tissue.	Curcumin	0-8	insulin like growth factor 1 receptor	Homo sapiens	107-112
28286973-4	2017	Ectopic expression of IGF2 and IGF1R, but not IGF1, in bladder cancer cells restored this process, suggesting that IGF2 is a target of curcumin.	Curcumin	135-143	insulin like growth factor 1 receptor	Homo sapiens	31-36
26053510-7	2015	Curcumin inhibits Abeta-induced increase of cellular Ca(2+) and depresses Abeta-induced phosphorylations of both NMDA receptor and cyclic AMP response element-binding protein (CREB) and activating transcription factor 1 (ATF-1).	Curcumin	0-8	activating transcription factor 1	Homo sapiens	221-226
28627596-0	2017	Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1beta is mediated by curcumin via inhibition of NF-kappaB signaling in rat chondrocytes.	Curcumin	119-127	matrix metallopeptidase 13	Rattus norvegicus	32-59
25179227-0	2015	Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice.	Curcumin	0-8	presenilin 1	Mus musculus	123-126
28789415-0	2017	Curcumin induces apoptotic cell death in human pancreatic cancer cells via the miR-340/XIAP signaling pathway.	Curcumin	0-8	X-linked inhibitor of apoptosis	Homo sapiens	87-91
28789415-3	2017	Results from the present study demonstrate that the miR-340/X-linked inhibitor of apoptosis (XIAP) signaling pathway mediates curcumin-induced pancreatic cancer cell apoptosis.	Curcumin	126-134	X-linked inhibitor of apoptosis	Homo sapiens	60-91
28789415-3	2017	Results from the present study demonstrate that the miR-340/X-linked inhibitor of apoptosis (XIAP) signaling pathway mediates curcumin-induced pancreatic cancer cell apoptosis.	Curcumin	126-134	X-linked inhibitor of apoptosis	Homo sapiens	93-97
28789415-7	2017	Furthermore, curcumin treatment significantly reduced XIAP expression, an effect that was rescued by treatment with anti-miR-340.	Curcumin	13-21	X-linked inhibitor of apoptosis	Homo sapiens	54-58
28789415-8	2017	The results of the present study suggest that the miR-340/XIAP signaling pathway is a downstream target of curcumin that mediates its proapoptotic effects on pancreatic cancer cells.	Curcumin	107-115	X-linked inhibitor of apoptosis	Homo sapiens	58-62
22256765-0	2011	[Curcumin down-regulates CX3CR1 expression in spinal cord dorsal horn and DRG in neuropathic pain rats].	Curcumin	1-9	C-X3-C motif chemokine receptor 1	Rattus norvegicus	25-31
22256765-8	2011	The administration of curcumin could significantly attenuate the activation of CX3CR1 induced by CCI.	Curcumin	22-30	C-X3-C motif chemokine receptor 1	Rattus norvegicus	79-85
22256765-9	2011	CONCLUSION: The study suggests that curcumin ameliorates the CCI-induced neuropathic pain, probably by attenuating the expression of CX3CR1 in spinal cord dorsal horn and dorsal root ganglia.	Curcumin	36-44	C-X3-C motif chemokine receptor 1	Rattus norvegicus	133-139
28684765-7	2017	Interestingly, CaCxSLCs treated with curcumin prior to UV-irradiation abolished AP-1 activity and a concomitant reduction in SP cells leading to abrogation of sphere forming ability, loss of proliferation, induction of apoptosis and the cells were poorly tumorigenic.	Curcumin	37-45	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-84
25179227-6	2015	Both curcumin and FMeC1 modulated the formation of Abeta aggregates; however, only FMeC1 significantly attenuated the cell toxicity of Abeta.	Curcumin	5-13	amyloid beta (A4) precursor protein	Mus musculus	51-56
28684765-8	2017	The curcumin pre-treatment abolished the expression of c-Fos and c-Jun but upregulated Fra-1 expression in UV-irradiated CaCxSLCs.	Curcumin	4-12	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-60
28684765-8	2017	The curcumin pre-treatment abolished the expression of c-Fos and c-Jun but upregulated Fra-1 expression in UV-irradiated CaCxSLCs.	Curcumin	4-12	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-70
21740906-3	2011	We demonstrate that both curcumin and nordihydroguaiaretic acid (NDGA) bind to TTR and stabilize the TTR tetramer.	Curcumin	25-33	transthyretin	Homo sapiens	79-82
21740906-3	2011	We demonstrate that both curcumin and nordihydroguaiaretic acid (NDGA) bind to TTR and stabilize the TTR tetramer.	Curcumin	25-33	transthyretin	Homo sapiens	101-104
21740906-4	2011	However, while NDGA slightly reduced TTR aggregation, curcumin strongly suppressed TTR amyloid fibril formation by generating small "off-pathway" oligomers and EGCG maintained most of the protein in a non-aggregated soluble form.	Curcumin	54-62	transthyretin	Homo sapiens	83-86
21740906-6	2011	Moreover, EGCG and curcumin efficiently disaggregated pre-formed TTR amyloid fibrils.	Curcumin	19-27	transthyretin	Homo sapiens	65-68
28448872-7	2017	Furthermore, we found that curcumin up-regulated the expression of nuclear Nrf2 and Nrf2-dependent antioxidant defense genes including heme oxygenase-1 (HO-1), glutamate-cysteine ligase (GCLC), NAD(P)H dehydrogenase, and quinone (NQO-1) in a dose-dependent manner.	Curcumin	27-35	heme oxygenase 1	Rattus norvegicus	153-157
25435978-9	2015	Curcumin and the VEGF blocker are each capable of inhibiting hepatocellular carcinoma progression by regulating the VEGF/VEGFR/K-ras pathway.	Curcumin	0-8	vascular endothelial growth factor A	Rattus norvegicus	116-120
25539644-8	2014	Pharmacological intervention of STAT3 using specific inhibitors like curcumin and Stattic that abrogated STAT3 activation resulted in loss of cellular miR-21 pool.	Curcumin	69-77	microRNA 21	Homo sapiens	151-157
25240837-11	2014	These data indicate that the early ceramide generation by nSMase2 induced by curcumin intensifies the later ceramide accumulation via inhibition of sphingomyelin synthase, and controls pro-apoptotic signaling.	Curcumin	77-85	sphingomyelin phosphodiesterase 3	Homo sapiens	58-65
28781948-5	2017	Western blot analysis was used to analyze caspase-3 expression in response to curcumin treatment.	Curcumin	78-86	caspase 3	Mus musculus	42-51
28781948-9	2017	Caspase-3 was upregulated by curcumin treatment.	Curcumin	29-37	caspase 3	Mus musculus	0-9
21659475-2	2011	Flexible VDR + ligand docking calculations predict that the major blood metabolite, 25(OH)-vitamin D(3) (25D3), and curcumin (CM) bind more selectively to the VDR-AP when compared with the seco-steroid hormone 1alpha,25(OH)(2)-vitamin D(3) (1,25D3).	Curcumin	116-124	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	9-12
21659475-2	2011	Flexible VDR + ligand docking calculations predict that the major blood metabolite, 25(OH)-vitamin D(3) (25D3), and curcumin (CM) bind more selectively to the VDR-AP when compared with the seco-steroid hormone 1alpha,25(OH)(2)-vitamin D(3) (1,25D3).	Curcumin	116-124	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	159-162
25033705-7	2014	RESULTS: Western-blotting: after the third generation of cells had been treated for 72 h, we observed that wnt3a and beta-catenin expression was significantly increased in the group receiving 500 nmol/L curcumin but not in the other groups.	Curcumin	203-211	catenin beta 1	Rattus norvegicus	117-129
21774804-9	2011	The residual tumors from APCMin +/- mice treated with dasatinib and/or curcumin showed 80-90% decrease in the expression of the CSC markers ALDH, CD44, CD133, CD166.	Curcumin	71-79	CD44 antigen	Mus musculus	146-150
21774804-9	2011	The residual tumors from APCMin +/- mice treated with dasatinib and/or curcumin showed 80-90% decrease in the expression of the CSC markers ALDH, CD44, CD133, CD166.	Curcumin	71-79	prominin 1	Mus musculus	152-157
28289922-10	2017	Significant inhibition in mRNA expression of iNOS, TGF-beta1 and TNF-alpha level was noted after curcumin treatment along with lowered MPO activity, inflammatory cell count, ROS, nitrite levels and collagen deposition in lungs.	Curcumin	97-105	myeloperoxidase	Mus musculus	135-138
28402926-0	2017	Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down-regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells.	Curcumin	0-8	C-X-C motif chemokine receptor 4	Homo sapiens	119-124
28402926-7	2017	Curcumin significantly up-regulated the expression of Slit-2 in Ishikawa, Hec-1B and primary endometrial cancer cells while it down-regulated the expression of stromal cell-derived factor-1 (SDF-1) and CXCR4 which in turn, suppressed the expression of matrix metallopeptidases (MMP) 2 and 9, thus attenuating the migration of endometrial cancer cells.	Curcumin	0-8	C-X-C motif chemokine receptor 4	Homo sapiens	202-207
25530715-8	2014	RESULTS: We demonstrated MCF-7 and MDA-MB-231 cells exhibited differential responses to curcumin by WST-1 and clonogenic assay (MDA-MB-231 cells was sensitive, and MCF-7 cells was resistant), which were found to be related to the differential curcumin-mediated regulation of SKP2-Cip/Kips (p21 and p27 but not p57) signaling.	Curcumin	88-96	H3 histone pseudogene 16	Homo sapiens	290-293
28402926-8	2017	In summary, we have demonstrated that curcumin has inhibitory effect on cellular migration via Slit-2 mediated down-regulation of CXCR4, SDF-1, and MMP2/MMP9 in endometrial carcinoma cells.	Curcumin	38-46	C-X-C motif chemokine receptor 4	Homo sapiens	130-135
28402926-8	2017	In summary, we have demonstrated that curcumin has inhibitory effect on cellular migration via Slit-2 mediated down-regulation of CXCR4, SDF-1, and MMP2/MMP9 in endometrial carcinoma cells.	Curcumin	38-46	matrix metallopeptidase 9	Homo sapiens	153-157
25530715-8	2014	RESULTS: We demonstrated MCF-7 and MDA-MB-231 cells exhibited differential responses to curcumin by WST-1 and clonogenic assay (MDA-MB-231 cells was sensitive, and MCF-7 cells was resistant), which were found to be related to the differential curcumin-mediated regulation of SKP2-Cip/Kips (p21 and p27 but not p57) signaling.	Curcumin	88-96	interferon alpha inducible protein 27	Homo sapiens	298-301
21545828-0	2011	Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: relationship to HO-1/CO antioxidant system.	Curcumin	27-35	heme oxygenase 1	Rattus norvegicus	120-124
26027129-6	2014	After the treatment with different concentrations of curcumin, Nuclear Nrf2 was decreased but Keapl was increased, and GSTP1 and NQO1 were decreased.	Curcumin	53-61	glutathione S-transferase pi 1	Homo sapiens	119-124
21545828-6	2011	Furthermore, curcumin pretreatment increased liver HO-1 (2.4-fold, p=0.001), but reduced NOS-2 (4.1-fold, p=0.01) expressions.	Curcumin	13-21	heme oxygenase 1	Rattus norvegicus	51-55
28489348-0	2017	Novel Curcumin Liposome Modified with Hyaluronan Targeting CD44 Plays an Anti-Leukemic Role in Acute Myeloid Leukemia in Vitro and in Vivo.	Curcumin	6-14	CD44 molecule (Indian blood group)	Homo sapiens	59-63
26027129-9	2014	The expression of typical phase I enzymes (GSTP1 and NQO1) mediated by Nrf2 are decreased by curcumin.	Curcumin	93-101	glutathione S-transferase pi 1	Homo sapiens	43-48
28489348-3	2017	To address these issues, we developed a novel curcumin liposome modified with hyaluronan (HA-Cur-LPs) to specifically deliver curcumin to AML by targeting CD44 on AML cell surface.	Curcumin	46-54	CD44 molecule (Indian blood group)	Homo sapiens	155-159
28489348-3	2017	To address these issues, we developed a novel curcumin liposome modified with hyaluronan (HA-Cur-LPs) to specifically deliver curcumin to AML by targeting CD44 on AML cell surface.	Curcumin	126-134	CD44 molecule (Indian blood group)	Homo sapiens	155-159
25118567-3	2014	In the present study, we show that two natural compounds, curcumin and emetine, bind tightly (Kd &lt; 1.6 muM) to the core amyloidogenic stretch (182-192) of gelsolin (AGel).	Curcumin	58-66	gelsolin	Homo sapiens	158-166
28573069-0	2017	Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice.	Curcumin	12-20	homeostatic iron regulator	Mus musculus	82-85
21529317-0	2011	Curcumin attenuates the expression and secretion of RANTES after spinal cord injury in vivo and lipopolysaccharide-induced astrocyte reactivation in vitro.	Curcumin	0-8	C-C motif chemokine ligand 5	Rattus norvegicus	52-58
21663638-11	2011	In addition, curcumin treatment also markedly decreased ICAM-1, MCP-1 and TGF-beta1 protein expression.	Curcumin	13-21	intercellular adhesion molecule 1	Rattus norvegicus	56-62
21332948-2	2011	Resveratrol, catechin, silymarin, dobutamin, and curcumin showed K(I) values in the range of 4.47-9.47 mm for hCA I and of 2.86-7.44 mum against hCA II, respectively.	Curcumin	49-57	carbonic anhydrase 1	Homo sapiens	110-115
21332948-2	2011	Resveratrol, catechin, silymarin, dobutamin, and curcumin showed K(I) values in the range of 4.47-9.47 mm for hCA I and of 2.86-7.44 mum against hCA II, respectively.	Curcumin	49-57	carbonic anhydrase 2	Homo sapiens	145-151
25118567-3	2014	In the present study, we show that two natural compounds, curcumin and emetine, bind tightly (Kd &lt; 1.6 muM) to the core amyloidogenic stretch (182-192) of gelsolin (AGel).	Curcumin	58-66	gelsolin	Homo sapiens	168-172
22053378-9	2011	The degrees of fibrosis were significantly alleviated; Compared with curcumin group, liver index and serum ALT, AST of curcumin derivative group were also significantly decreased [(4.88 +/- 0.62) vs (5.16 +/- 0.61); (69.20 +/- 27.58) vs (82.5 +/- 33.23); (158.00 +/- 39.15) vs (211.75 +/- 106.30), P &lt; 0.05]; The liver steatosis and inflammation grade were also significantly improved .The gene transcriptions of TNF alpha, NF-kappa B and HMG-CoA reductase in curcumin derivative group were significantly lower than those in curcumin and saline group (P &lt; 0.05).	Curcumin	119-127	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	442-459
22053378-9	2011	The degrees of fibrosis were significantly alleviated; Compared with curcumin group, liver index and serum ALT, AST of curcumin derivative group were also significantly decreased [(4.88 +/- 0.62) vs (5.16 +/- 0.61); (69.20 +/- 27.58) vs (82.5 +/- 33.23); (158.00 +/- 39.15) vs (211.75 +/- 106.30), P &lt; 0.05]; The liver steatosis and inflammation grade were also significantly improved .The gene transcriptions of TNF alpha, NF-kappa B and HMG-CoA reductase in curcumin derivative group were significantly lower than those in curcumin and saline group (P &lt; 0.05).	Curcumin	119-127	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	442-459
25315241-0	2014	Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/beta-catenin negative feedback loop.	Curcumin	0-8	catenin beta 1	Homo sapiens	81-93
22053378-9	2011	The degrees of fibrosis were significantly alleviated; Compared with curcumin group, liver index and serum ALT, AST of curcumin derivative group were also significantly decreased [(4.88 +/- 0.62) vs (5.16 +/- 0.61); (69.20 +/- 27.58) vs (82.5 +/- 33.23); (158.00 +/- 39.15) vs (211.75 +/- 106.30), P &lt; 0.05]; The liver steatosis and inflammation grade were also significantly improved .The gene transcriptions of TNF alpha, NF-kappa B and HMG-CoA reductase in curcumin derivative group were significantly lower than those in curcumin and saline group (P &lt; 0.05).	Curcumin	119-127	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	442-459
21589925-9	2011	Inhibitors for MEK1/2 (PD98059), JNK (SP600125) or AP1 (curcumin) significantly inhibited MCP-1-induced amylin mRNA expression.	Curcumin	56-64	chemokine (C-C motif) ligand 2	Mus musculus	90-95
25315241-10	2014	In contrast, curcumin inhibits beta-catenin nuclear translocation, thus impeding trans-activation of Slug.	Curcumin	13-21	catenin beta 1	Homo sapiens	31-43
21343524-8	2011	The post-TBI dietary supplementation of the curcumin derivative normalized levels of BDNF, and its downstream effectors on synaptic plasticity (CREB, synapsin I) and neuronal signaling (CaMKII), as well as levels of oxidative stress-related molecules (SOD, Sir2).	Curcumin	44-52	brain-derived neurotrophic factor	Rattus norvegicus	85-89
28469096-9	2017	Furthermore, the Western blotting of ovarian tissues showed that the p66Shc expression upregulated under oxidative stress would be lowered by curcumin.	Curcumin	142-150	src homology 2 domain-containing transforming protein C1	Mus musculus	69-75
25315241-12	2014	CONCLUSIONS: Cumulatively, our findings disclose that curcumin inhibits bCSC migration by amplifying E-cadherin/beta-catenin negative feedback loop.	Curcumin	54-62	catenin beta 1	Homo sapiens	112-124
26956464-0	2017	Curcumin reduces cardiac fibrosis by inhibiting myofibroblast differentiation and decreasing transforming growth factor beta1 and matrix metalloproteinase 9 / tissue inhibitor of metalloproteinase 1.	Curcumin	0-8	matrix metallopeptidase 9	Rattus norvegicus	130-156
21343524-8	2011	The post-TBI dietary supplementation of the curcumin derivative normalized levels of BDNF, and its downstream effectors on synaptic plasticity (CREB, synapsin I) and neuronal signaling (CaMKII), as well as levels of oxidative stress-related molecules (SOD, Sir2).	Curcumin	44-52	synapsin I	Rattus norvegicus	150-160
21237271-0	2011	Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism.	Curcumin	0-8	synuclein alpha	Rattus norvegicus	31-46
26956464-0	2017	Curcumin reduces cardiac fibrosis by inhibiting myofibroblast differentiation and decreasing transforming growth factor beta1 and matrix metalloproteinase 9 / tissue inhibitor of metalloproteinase 1.	Curcumin	0-8	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	159-198
21237271-5	2011	Here we test whether curcumin, a potent antioxidant compound, derived from the curry spice turmeric, can protect against mutant A53T alpha-synuclein-induced cell death.	Curcumin	21-29	synuclein alpha	Rattus norvegicus	133-148
25201116-6	2014	Furthermore, curcumin also inhibited the SCI-associated aquaporin - 4 (AQP4) overexpression and glial fibrillary acidic protein (GFAP) and repressed the unusual activation of the JAK/STAT signaling pathway.	Curcumin	13-21	aquaporin 4	Rattus norvegicus	71-75
21237271-7	2011	We found that curcumin protected against A53T alpha-synuclein-induced cell death in a dose-dependent manner.	Curcumin	14-22	synuclein alpha	Rattus norvegicus	46-61
21237271-8	2011	We further found that curcumin can reduce mutant alpha- synuclein-induced intracellular reactive oxygen species (ROS) levels, mitochondrial depolarization, cytochrome c release, and caspase-9 and caspase-3 activation.	Curcumin	22-30	synuclein alpha	Rattus norvegicus	49-65
21237271-9	2011	This study demonstrate that curcumin protected against A53T mutant alpha-synuclein-induced cell death via inhibition of oxidative stress and the mitochondrial cell death pathway, suggesting that curcumin may be a candidate neuroprotective agent for A53T alpha-synuclein-linked Parkinsonism, and possibly for other genetic or sporadic forms of PD.	Curcumin	28-36	synuclein alpha	Rattus norvegicus	67-82
21237271-9	2011	This study demonstrate that curcumin protected against A53T mutant alpha-synuclein-induced cell death via inhibition of oxidative stress and the mitochondrial cell death pathway, suggesting that curcumin may be a candidate neuroprotective agent for A53T alpha-synuclein-linked Parkinsonism, and possibly for other genetic or sporadic forms of PD.	Curcumin	28-36	synuclein alpha	Rattus norvegicus	254-269
21237271-9	2011	This study demonstrate that curcumin protected against A53T mutant alpha-synuclein-induced cell death via inhibition of oxidative stress and the mitochondrial cell death pathway, suggesting that curcumin may be a candidate neuroprotective agent for A53T alpha-synuclein-linked Parkinsonism, and possibly for other genetic or sporadic forms of PD.	Curcumin	195-203	synuclein alpha	Rattus norvegicus	67-82
26956464-10	2017	Curcumin also inhibited fibrosis by inhibiting myofibroblast differentiation, decreased TGF-beta1, MMP-9 and TIMP-1 expression (P&lt;0.05) but had no effects on Smad3 in Ang II incubated cardiac fibroblasts.	Curcumin	0-8	matrix metallopeptidase 9	Rattus norvegicus	99-104
26956464-10	2017	Curcumin also inhibited fibrosis by inhibiting myofibroblast differentiation, decreased TGF-beta1, MMP-9 and TIMP-1 expression (P&lt;0.05) but had no effects on Smad3 in Ang II incubated cardiac fibroblasts.	Curcumin	0-8	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	109-115
26956464-11	2017	CONCLUSIONS: Curcumin reduces cardiac fibrosis in rats and Ang II-induced fibroblast proliferation by inhibiting myofibroblast differentiation, decreasing collagen synthesis and accelerating collagen degradation through reduction of TGF-beta1, MMPs/TIMPs.	Curcumin	13-21	matrix metallopeptidase 9	Rattus norvegicus	244-248
28102474-2	2017	Hence, this study sought to assess the combined pretreatment effect of curcumin, the major polyphenolic compound of turmeric (Curcuma longa) rhizomes, with donepezil, a cholinesterase inhibitor, on cognitive function in scopolamine-induced memory impairment in rats.	Curcumin	71-79	butyrylcholinesterase	Rattus norvegicus	169-183
28102474-9	2017	However, combination of curcumin and donepezil improves learning and memory activity associated with inhibitory effect on AChE, BuChE, and ADA activities as compared to control.	Curcumin	24-32	adenosine deaminase	Rattus norvegicus	139-142
28430129-9	2017	Curcumin can increase the expression of phosphorylated extracellular signal-regulated kinases 1/2 (ERK1/2), autophagy marker light chain 3 (LC3)-II, and Beclin-1 in chondrocytes.	Curcumin	0-8	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	140-143
28430129-9	2017	Curcumin can increase the expression of phosphorylated extracellular signal-regulated kinases 1/2 (ERK1/2), autophagy marker light chain 3 (LC3)-II, and Beclin-1 in chondrocytes.	Curcumin	0-8	beclin 1	Homo sapiens	153-161
22291761-4	2011	The aim of this study was to investigate whether SMN2 expression can be increased by caffeic acid, chlorogenic acid and curcumin, which are designed by modifications of the carboxylic acid class of histone deacetylase (HDAC) inhibitors.	Curcumin	120-128	histone deacetylase 9	Homo sapiens	198-217
22291761-4	2011	The aim of this study was to investigate whether SMN2 expression can be increased by caffeic acid, chlorogenic acid and curcumin, which are designed by modifications of the carboxylic acid class of histone deacetylase (HDAC) inhibitors.	Curcumin	120-128	histone deacetylase 9	Homo sapiens	219-223
21485083-10	2011	CONCLUSION: Curcumin could improve learning and memory Ca2+/capacities of SAM by lowering hippocampal [Ca2+] overload, increase the hippocampal CaM mRNA level and CaMK II expression in the hippocampal dose-dependently.	Curcumin	12-20	calmodulin 2	Mus musculus	144-147
21347286-7	2011	Curcumin increased the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) mRNA, but protein levels were lower.	Curcumin	0-8	vascular endothelial growth factor A	Mus musculus	66-100
21347286-7	2011	Curcumin increased the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) mRNA, but protein levels were lower.	Curcumin	0-8	vascular endothelial growth factor A	Mus musculus	102-106
21347286-8	2011	Furthermore, curcumin increased the expression of RNA binding proteins CUGBP2/CELF2 and TIA-1.	Curcumin	13-21	cytotoxic granule-associated RNA binding protein 1	Mus musculus	88-93
25201116-7	2014	In conclusion, our data demonstrate that curcumin exhibits a moderately protective effect on spinal cord injury, and this effect might be related to the inhibition of overexpressed AQP4 and GFAP and the activated JAK/STAT signaling pathway.	Curcumin	41-49	aquaporin 4	Rattus norvegicus	181-185
21347286-11	2011	CONCLUSION/SIGNIFICANCE: Curcumin inhibits pancreatic tumor growth through mitotic catastrophe by increasing the expression of RNA binding protein CUGBP2, thereby inhibiting the translation of COX-2 and VEGF mRNA.	Curcumin	25-33	vascular endothelial growth factor A	Mus musculus	203-207
28336111-6	2017	Moreover, the increase in the expression of Rac1, Rac1-GTP, and NOX1 observed in BDL rats was precluded and reversed back toward normalcy by curcumin treatment (P &lt; 0.05).	Curcumin	141-149	NADPH oxidase 1	Rattus norvegicus	64-68
28336111-8	2017	CONCLUSIONS: Curcumin attenuated liver damage through the downregulation of Rac1, Rac1-GTP, and NOX1 as well as reduced oxidative stress in the serum and liver tissue of BDL rats.	Curcumin	13-21	NADPH oxidase 1	Rattus norvegicus	96-100
24848068-0	2014	Inhibition of JNK phosphorylation by a novel curcumin analog prevents high glucose-induced inflammation and apoptosis in cardiomyocytes and the development of diabetic cardiomyopathy.	Curcumin	45-53	mitogen-activated protein kinase 8	Rattus norvegicus	14-17
28350049-0	2017	Activation of the CRABPII/RAR pathway by curcumin induces retinoic acid mediated apoptosis in retinoic acid resistant breast cancer cells.	Curcumin	41-49	cellular retinoic acid binding protein 2	Homo sapiens	18-25
28350049-6	2017	We provide evidence that curcumin upregulates the expression of CRABPII, RARbeta and RARgamma in two different TNBC cell lines.	Curcumin	25-33	cellular retinoic acid binding protein 2	Homo sapiens	64-71
28350049-8	2017	Additionally, silencing CRABPII reverses curcumin sensitization of TNBC cells to the apoptotic inducing effects of RA.	Curcumin	41-49	cellular retinoic acid binding protein 2	Homo sapiens	24-31
28350049-9	2017	These findings provide mechanistic insights into sensitizing TNBC cells to RA-mediated cell death by curcumin-induced upregulation of the CRABPII/RAR pathway.	Curcumin	101-109	cellular retinoic acid binding protein 2	Homo sapiens	138-145
28377720-4	2017	Moreover, the effect of curcumin on CYP2A6 is illustrated.	Curcumin	24-32	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	36-42
28377720-13	2017	However, curcumin treatment inhibited CYP2A6 at mRNA and protein levels in AFB1 treated AA broiler in a dose-dependent manner.	Curcumin	9-17	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	38-44
28377720-14	2017	Maximum inhibition of liver CYP2A6 enzyme activity in AA broiler has been achieved at a dose of 450 mg/kg curcumin.	Curcumin	106-114	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	28-34
28377720-15	2017	This is the first study identifying and confirming the role of CYP2A6 enzyme in AFB1 bioactivation in AA broiler liver (in vivo), and the hepatoprotective role of curcumin via inhibiting CYP2A6 expression and enzyme activity.	Curcumin	163-171	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	187-193
21461234-2	2011	In HCT116 human colon cancer cells, we found that curcumin, a polyphenolic phytochemical extracted from the plant Curcuma longa, markedly induced the conversion of microtubule-associated protein 1 light chain 3 (LC3)-I to LC3-II and degradation of sequestome-1 (SQSTM1) which is a marker of autophagosome degradation.	Curcumin	50-58	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	212-215
21461234-2	2011	In HCT116 human colon cancer cells, we found that curcumin, a polyphenolic phytochemical extracted from the plant Curcuma longa, markedly induced the conversion of microtubule-associated protein 1 light chain 3 (LC3)-I to LC3-II and degradation of sequestome-1 (SQSTM1) which is a marker of autophagosome degradation.	Curcumin	50-58	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	222-225
21461234-3	2011	Moreover, we found that curcumin caused GFP-LC3 formation puncta, a marker of autophagosome, and decrease of GFP-LC3 and SQSTM1 protein level in GFP-LC3 expressing HCT116 cells.	Curcumin	24-32	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	44-47
21461234-3	2011	Moreover, we found that curcumin caused GFP-LC3 formation puncta, a marker of autophagosome, and decrease of GFP-LC3 and SQSTM1 protein level in GFP-LC3 expressing HCT116 cells.	Curcumin	24-32	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	113-116
21461234-3	2011	Moreover, we found that curcumin caused GFP-LC3 formation puncta, a marker of autophagosome, and decrease of GFP-LC3 and SQSTM1 protein level in GFP-LC3 expressing HCT116 cells.	Curcumin	24-32	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	113-116
21461234-4	2011	It was further confirmed that treatment of cells with hydrogen peroxide induced increase of LC3 conversion and decrease of GFP-LC3 and SQSTM1 levels, but these changes by curcumin were almost completely blocked in the presence of antioxidant, N-acetylcystein (NAC), indicating that curcumin leads to reactive oxygen species (ROS) production, which results in autophagosome development and autolysosomal degradation.	Curcumin	171-179	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	92-95
21461234-4	2011	It was further confirmed that treatment of cells with hydrogen peroxide induced increase of LC3 conversion and decrease of GFP-LC3 and SQSTM1 levels, but these changes by curcumin were almost completely blocked in the presence of antioxidant, N-acetylcystein (NAC), indicating that curcumin leads to reactive oxygen species (ROS) production, which results in autophagosome development and autolysosomal degradation.	Curcumin	171-179	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	127-130
20574713-6	2011	The elevated translated product of Cu/Zn-SOD, Mn-SOD and catalase in T(4)-treated rats were differentially reduced by the administration of vitamin E and curcumin independently or in combination.	Curcumin	154-162	superoxide dismutase 2	Rattus norvegicus	46-52
20574713-7	2011	Cu/Zn-SOD expression was ameliorated by both vitamin E and curcumin independently or in combination, whereas Mn-SOD expression was ameliorated by the supplementation of vitamin E or curcumin independently.	Curcumin	182-190	superoxide dismutase 2	Rattus norvegicus	109-115
21183341-4	2011	2-Hydroxycurcuminoid (HCC-7) strongly inhibited the growth of SW620 colon tumor cells with a GI(50) value of 7muM, while the parent compounds, HCA and curcumin, displayed GI(50) values of 12 and 30muM, respectively.	Curcumin	9-17	hexosaminidase subunit beta	Homo sapiens	22-27
28198625-4	2017	According to the histopathological examination of liver tissues and biomarker detection in serum and livers, it was demonstrated that curcumin attenuated DEN-induced hepatocarcinogenesis through parts of regulating the oxidant stress enzymes (T-SOD and CAT), liver function (ALT and AST) and LDHA, AFP level, and COX-2/PGE2 pathway.	Curcumin	134-142	alpha fetoprotein	Mus musculus	298-301
24706026-12	2014	The results of the present study suggested that Notch1 and Notch2 receptor, major Notch1 receptor, played an important role in the development of allergic airway inflammation and the inhibition of Notch1-GATA3 signaling pathway by curcumin can prevent the development and deterioration of the allergic airway inflammation.	Curcumin	231-239	notch 1	Mus musculus	48-54
24706026-12	2014	The results of the present study suggested that Notch1 and Notch2 receptor, major Notch1 receptor, played an important role in the development of allergic airway inflammation and the inhibition of Notch1-GATA3 signaling pathway by curcumin can prevent the development and deterioration of the allergic airway inflammation.	Curcumin	231-239	notch 1	Mus musculus	82-88
21130735-6	2011	Importantly, we demonstrate a marked decrease in synphilin-1 aggregation when the cell line is previously incubated with 3,5-bis(2-flurobenzylidene) piperidin-4-one (EF-24), a curcumin analogue, prior to rotenone insult.	Curcumin	176-184	synuclein alpha interacting protein	Homo sapiens	49-60
24706026-12	2014	The results of the present study suggested that Notch1 and Notch2 receptor, major Notch1 receptor, played an important role in the development of allergic airway inflammation and the inhibition of Notch1-GATA3 signaling pathway by curcumin can prevent the development and deterioration of the allergic airway inflammation.	Curcumin	231-239	notch 1	Mus musculus	82-88
21078213-2	2011	Using a luciferase reporter gene assay, we tested curcumin for its ability to induce PON1 in Huh7 hepatocytes in culture.	Curcumin	50-58	MIR7-3 host gene	Homo sapiens	93-97
28257515-5	2017	Conversely, oral administration of curcumin prevented HFD-induced liver injury, metabolic alterations, intrahepatic CD4+ cell accumulation and the linoleic acid- and leptin- induced pro-inflammatory and pro-oxidant effects on mouse liver macrophages.	Curcumin	35-43	CD4 antigen	Mus musculus	116-119
21078213-3	2011	Curcumin ( &gt;= 10 mumol/l) dose-dependently induced PON1 transactivation in Huh7 cells.	Curcumin	0-8	MIR7-3 host gene	Homo sapiens	78-82
24706026-12	2014	The results of the present study suggested that Notch1 and Notch2 receptor, major Notch1 receptor, played an important role in the development of allergic airway inflammation and the inhibition of Notch1-GATA3 signaling pathway by curcumin can prevent the development and deterioration of the allergic airway inflammation.	Curcumin	231-239	GATA binding protein 3	Mus musculus	204-209
28196290-0	2017	Curcumin Protects Against Intestinal Origin Endotoxemia in Rat Liver Cirrhosis by Targeting PCSK9.	Curcumin	0-8	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	92-97
20851953-7	2010	Curcumin was highly effective at suppressing growth of SCC40 xenografts and its activity is associated with modulation of MTOR"s downstream target pS6.	Curcumin	0-8	taste 2 receptor member 63 pseudogene	Homo sapiens	147-150
28196290-9	2017	The results showed that PCSK9 significantly decreased both gene and protein levels in the rat liver tissues of curcumin treatment.	Curcumin	111-119	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	24-29
24723245-11	2014	Curcumin significantly reduced neurological deficit scores, cerebral infarct size, neuronal damage, cerebral water content, and MPO activity.	Curcumin	0-8	myeloperoxidase	Rattus norvegicus	128-131
28196290-10	2017	Thus, we concluded that curcumin could function to protect against intestinal origin endotoxemia by inhibiting PCSK9 to promote LDLR expression, thereby enhancing LPS detoxification as one pathogen lipid through LDLR in the liver.	Curcumin	24-32	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	111-116
20851953-9	2010	A major cause of lethal progression of HNSCC is local regional migration and invasion of malignant cells, and curcumin significantly inhibited cancer cell migration and invasion in vitro and in vivo where downregulation of pS6 was associated with a significant decrease in MMP-9.	Curcumin	110-118	taste 2 receptor member 63 pseudogene	Homo sapiens	223-226
20851953-9	2010	A major cause of lethal progression of HNSCC is local regional migration and invasion of malignant cells, and curcumin significantly inhibited cancer cell migration and invasion in vitro and in vivo where downregulation of pS6 was associated with a significant decrease in MMP-9.	Curcumin	110-118	matrix metallopeptidase 9	Homo sapiens	273-278
28239299-0	2017	Synthetic curcumin derivative DK1 possessed G2/M arrest and induced apoptosis through accumulation of intracellular ROS in MCF-7 breast cancer cells.	Curcumin	10-18	immunoglobulin heavy diversity 5-12	Homo sapiens	30-33
21073732-0	2010	Curcumin activates the p38MPAK-HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC.	Curcumin	0-8	heat shock protein 1	Mus musculus	23-36
24970744-5	2014	Curcumin promoted post-ischemic blood recirculation and suppressed lung cancer progression in inbred C57BL/6 mice via regulation of the HIF1alpha/mTOR/VEGF/VEGFR cascade oppositely.	Curcumin	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	136-145
21073732-7	2010	RESULTS: Curcumin enhanced the phosphorylation of both p38MAPK and downstream HSP25; inhibited COX-2; induced a trend towards attenuation of F- to G-actin cleavage; and dramatically inhibited the activation of caspase-3 in vitro.	Curcumin	9-17	heat shock protein 1	Mus musculus	78-83
21073732-7	2010	RESULTS: Curcumin enhanced the phosphorylation of both p38MAPK and downstream HSP25; inhibited COX-2; induced a trend towards attenuation of F- to G-actin cleavage; and dramatically inhibited the activation of caspase-3 in vitro.	Curcumin	9-17	caspase 3	Mus musculus	210-219
20977462-0	2010	Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase.	Curcumin	0-8	glucokinase	Homo sapiens	140-151
20977462-11	2010	Furthermore, curcumin stimulated glucokinase activity, increasing conversion of glucose to G-6-P.	Curcumin	13-21	glucokinase	Homo sapiens	33-44
28239299-4	2017	MAIN METHODS: A curcumin derivative (Z)-3-hydroxy-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one (DK1) was synthesized and its cytotoxicity was tested on breast cancer cell MCF-7 and normal cell MCF-10A using MTT assay.	Curcumin	16-24	immunoglobulin heavy diversity 5-12	Homo sapiens	95-98
28165402-0	2017	Inhibition of Cell Survival by Curcumin Is Associated with Downregulation of Cell Division Cycle 20 (Cdc20) in Pancreatic Cancer Cells.	Curcumin	31-39	cell division cycle 20	Homo sapiens	77-99
28165402-0	2017	Inhibition of Cell Survival by Curcumin Is Associated with Downregulation of Cell Division Cycle 20 (Cdc20) in Pancreatic Cancer Cells.	Curcumin	31-39	cell division cycle 20	Homo sapiens	101-106
28165402-4	2017	In the current study, we explore whether curcumin exhibits its anti-cancer function through inhibition of oncoprotein cell division cycle 20 (Cdc20) in pancreatic cancer cells.	Curcumin	41-49	cell division cycle 20	Homo sapiens	118-140
28165402-4	2017	In the current study, we explore whether curcumin exhibits its anti-cancer function through inhibition of oncoprotein cell division cycle 20 (Cdc20) in pancreatic cancer cells.	Curcumin	41-49	cell division cycle 20	Homo sapiens	142-147
27743775-6	2017	In vitro studies have shown that curcumin can decrease MCP-1 production in various cell lines.	Curcumin	33-41	chemokine (C-C motif) ligand 2	Mus musculus	55-60
24970744-5	2014	Curcumin promoted post-ischemic blood recirculation and suppressed lung cancer progression in inbred C57BL/6 mice via regulation of the HIF1alpha/mTOR/VEGF/VEGFR cascade oppositely.	Curcumin	0-8	mechanistic target of rapamycin kinase	Mus musculus	146-150
20087857-4	2010	While investigating the mechanism of its action in vivo, we observed that curcumin decreased the gelatinolytic activities of matrix metalloproteinase-9.	Curcumin	74-82	matrix metallopeptidase 9	Homo sapiens	125-151
24970744-6	2014	Inflammatory stimulation induced by neutrophil elastase (NE) promoted angiogenesis in lung cancer tissues, but these changes were reversed by curcumin through directly reducing NE secretion and stimulating alpha1-antitrypsin (alpha1-AT) and insulin receptor substrate-1 (IRS-1) production.	Curcumin	142-150	insulin receptor substrate 1	Mus musculus	241-269
24970744-6	2014	Inflammatory stimulation induced by neutrophil elastase (NE) promoted angiogenesis in lung cancer tissues, but these changes were reversed by curcumin through directly reducing NE secretion and stimulating alpha1-antitrypsin (alpha1-AT) and insulin receptor substrate-1 (IRS-1) production.	Curcumin	142-150	insulin receptor substrate 1	Mus musculus	271-276
24970744-8	2014	Curcumin had opposite effects on blood vessel regeneration under physiological and pathological angiogenesis, which was effected through negative or positive regulation of the HIF1alpha/mTOR/VEGF/VEGFR cascade.	Curcumin	0-8	hypoxia inducible factor 1, alpha subunit	Mus musculus	176-185
24970744-8	2014	Curcumin had opposite effects on blood vessel regeneration under physiological and pathological angiogenesis, which was effected through negative or positive regulation of the HIF1alpha/mTOR/VEGF/VEGFR cascade.	Curcumin	0-8	mechanistic target of rapamycin kinase	Mus musculus	186-190
24651933-7	2014	The increased phosphorylation of p38 and JNK induced by OGD was decreased under the treatment of curcumin, whereas the p38 inhibitor, SB203580, significantly inhibited OGD-induced IL-1beta production, but the JNK inhibitor, SP600125, failed to do so.	Curcumin	97-105	mitogen-activated protein kinase 8	Rattus norvegicus	41-44
28045549-5	2017	RESULTS: As indicated by BrdU and MTT, curcumin significantly decreased the cell proliferation of five cell lines (HT1080, SW872, SYO1, 1273, and U2197) and the viability of two cell lines (SW872 and SW982).	Curcumin	39-47	HEAT repeat containing 3	Homo sapiens	130-134
24651933-7	2014	The increased phosphorylation of p38 and JNK induced by OGD was decreased under the treatment of curcumin, whereas the p38 inhibitor, SB203580, significantly inhibited OGD-induced IL-1beta production, but the JNK inhibitor, SP600125, failed to do so.	Curcumin	97-105	mitogen-activated protein kinase 8	Rattus norvegicus	209-212
27995523-7	2017	CONCLUSION: Over time, dual drug formulations (curcumin and docosahexaenoic acid (DHA)) promoted the neuronal survival and repair processes through enhanced BDNF secretion and increased phosphorylation of CREB as compared to untreated degenerating cells.	Curcumin	47-55	brain derived neurotrophic factor	Homo sapiens	157-161
25176384-7	2014	MTT assay was performed on the optimized formulation and the results are indicative that curcumin SLN showed better cytotoxicity in low dose while compared to plain curcumin.	Curcumin	89-97	sarcolipin	Homo sapiens	98-101
27995523-7	2017	CONCLUSION: Over time, dual drug formulations (curcumin and docosahexaenoic acid (DHA)) promoted the neuronal survival and repair processes through enhanced BDNF secretion and increased phosphorylation of CREB as compared to untreated degenerating cells.	Curcumin	47-55	cAMP responsive element binding protein 1	Homo sapiens	205-209
25230870-16	2014	Mechanism of effect of curcumin on MPT may be related to reduction of intracellular calcium concentration, promotion of anti-apoptotic Bcl-2 gene expression, inhibition of caspase-3 activation and Bax gene.	Curcumin	23-31	BCL2 associated X, apoptosis regulator	Rattus norvegicus	197-200
27882569-6	2017	Also observed was a time-dependent inhibition of the hepatic expression of UGT1A6, 1A8, SULT1A1, 1A3, and the colonic expression of UGT1A6 that occurred within 6 h of piperine pre-treatment but was reversed at 8 h, which correlated with the changes in curcumin exposure.	Curcumin	252-260	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	132-138
24960549-1	2014	Curcumin is known to trigger ER-stress induced cell death of acute promyelocytic leukemic (APL) cells by intercepting the degradation of nuclear co-repressor (N-CoR) protein which has a key role in the pathogenesis of APL.	Curcumin	0-8	nuclear receptor corepressor 1	Homo sapiens	137-157
28848078-0	2017	Targeting the Endocannabinoid/CB1 Receptor System For Treating Major Depression Through Antidepressant Activities of Curcumin and Dexanabinol-Loaded Solid Lipid Nanoparticles.	Curcumin	117-125	cannabinoid receptor 1	Rattus norvegicus	30-33
27592626-9	2017	CONCLUSION: This study shows that curcumin inhibits tumor growth by inhibiting VEGF/Ang-2/TSP-1- mediated angiogenesis in a xenograft glioma mouse model.	Curcumin	34-42	vascular endothelial growth factor A	Mus musculus	79-83
24960549-1	2014	Curcumin is known to trigger ER-stress induced cell death of acute promyelocytic leukemic (APL) cells by intercepting the degradation of nuclear co-repressor (N-CoR) protein which has a key role in the pathogenesis of APL.	Curcumin	0-8	nuclear receptor corepressor 1	Homo sapiens	159-164
25051175-8	2014	Furthermore, curcumin, a natural selective inhibitor of p300 in HATs, significantly suppressed the expression of PS1 and BACE1 through inhibition of H3 acetylation in their promoter regions in N2a/APPswe cells.	Curcumin	13-21	presenilin 1	Mus musculus	113-116
27719648-9	2017	Statins, telmisartan, and curcumin have been used for suppression of RAGE.	Curcumin	26-34	long intergenic non-protein coding RNA 914	Homo sapiens	69-73
27774900-7	2017	Therefore, in this review, we focus on 4 phytochemicals (quercetin, sulforaphane, iridoids, and curcumin) and summarize their effects on AGE formation as well as RAGE-mediated signaling pathway in various cell types and organs, including endothelial cells, vessels, and heart.	Curcumin	96-104	long intergenic non-protein coding RNA 914	Homo sapiens	162-166
28228072-7	2017	Specifically, curcumin"s anti-inflammatory effects are thought to be caused by reducing trans-endothelial monocyte migration by reduction of mRNA and protein expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and P-selectin and by modulating NFkappaB, JNK, p38 and STAT-3 in endothelial cells.	Curcumin	14-22	intercellular adhesion molecule 1	Homo sapiens	172-205
25051175-8	2014	Furthermore, curcumin, a natural selective inhibitor of p300 in HATs, significantly suppressed the expression of PS1 and BACE1 through inhibition of H3 acetylation in their promoter regions in N2a/APPswe cells.	Curcumin	13-21	beta-site APP cleaving enzyme 1	Mus musculus	121-126
25187683-4	2014	Therefore, the predicted structure of HBx using threading in LOMET was used for docking against plant derived natural compounds (curcumin, oleanolic acid, resveratrol, bilobetin, luteoline, ellagic acid, betulinic acid and rutin) by Molegro Virtual Docker.	Curcumin	129-137	X protein	Hepatitis B virus	38-41
28228072-8	2017	Dietary curcumin supplementation can also increase antioxidant activity through the induction of heme oxygenase-1, a scavenger of free radicals, and by reduction of reactive oxygen species and Nox-2.	Curcumin	8-16	cytochrome b-245 beta chain	Homo sapiens	193-198
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	Curcumin	79-87	apolipoprotein A1	Rattus norvegicus	180-197
28203261-0	2017	Curcumin Suppresses Intestinal Fibrosis by Inhibition of PPARgamma-Mediated Epithelial-Mesenchymal Transition.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	57-66
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	Curcumin	79-87	apolipoprotein A1	Rattus norvegicus	199-204
28203261-4	2017	Here we found that curcumin pretreatment significantly represses TGF-beta1-induced Smad pathway and decreases its downstream alpha-smooth muscle actin (alpha-SMA) gene expression in intestinal epithelial cells (IEC-6); in contrast, curcumin increases expression of E-cadherin and peroxisome proliferator-activated receptor gamma (PPARgamma) in IEC-6.	Curcumin	19-27	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	280-328
28203261-4	2017	Here we found that curcumin pretreatment significantly represses TGF-beta1-induced Smad pathway and decreases its downstream alpha-smooth muscle actin (alpha-SMA) gene expression in intestinal epithelial cells (IEC-6); in contrast, curcumin increases expression of E-cadherin and peroxisome proliferator-activated receptor gamma (PPARgamma) in IEC-6.	Curcumin	19-27	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	330-339
24746751-4	2014	Intranasal curcumin (5mg/kg) was administered from days 21 to 55, an hour before every nebulization and inflammatory cells recruitment, levels of IgE, EPO, IL-4 and IL-5 were found suppressed in bronchoalveolar lavage fluid (BALF).	Curcumin	11-19	erythropoietin	Mus musculus	151-154
28203261-5	2017	Moreover, curcumin promotes nuclear translocation of PPARgamma and the inhibitory effect of curcumin on EMT could be reversed by PPARgamma antagonist GW9662.	Curcumin	10-18	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	53-62
28203261-5	2017	Moreover, curcumin promotes nuclear translocation of PPARgamma and the inhibitory effect of curcumin on EMT could be reversed by PPARgamma antagonist GW9662.	Curcumin	10-18	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	129-138
28203261-5	2017	Moreover, curcumin promotes nuclear translocation of PPARgamma and the inhibitory effect of curcumin on EMT could be reversed by PPARgamma antagonist GW9662.	Curcumin	92-100	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	129-138
28203261-6	2017	Consistently, in the rat model of intestinal fibrosis induced by 2,4,5-trinitrobenzene sulphonic acid (TNBS), oral curcumin attenuates intestinal fibrosis by increasing the expression of PPARgamma and E-cadherin and decreasing the expression of alpha-SMA, FN, and CTGF in colon tissue.	Curcumin	115-123	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	187-196
28203261-7	2017	Collectively, these results indicated that curcumin is able to prevent EMT progress in intestinal fibrosis by PPARgamma-mediated repression of TGF-beta1/Smad pathway.	Curcumin	43-51	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	110-119
24746751-4	2014	Intranasal curcumin (5mg/kg) was administered from days 21 to 55, an hour before every nebulization and inflammatory cells recruitment, levels of IgE, EPO, IL-4 and IL-5 were found suppressed in bronchoalveolar lavage fluid (BALF).	Curcumin	11-19	interleukin 4	Mus musculus	156-160
29975823-3	2017	After combined use of doxorubicin and curcumin the content of TBARS and H(2)0(2) increased by 14 and 26%, respectively, the enzymatic activity of catalase decreased by 28%, and mitochondrial Mn-SOD activity intensified by 9%.	Curcumin	38-46	superoxide dismutase 2	Rattus norvegicus	191-197
24746751-4	2014	Intranasal curcumin (5mg/kg) was administered from days 21 to 55, an hour before every nebulization and inflammatory cells recruitment, levels of IgE, EPO, IL-4 and IL-5 were found suppressed in bronchoalveolar lavage fluid (BALF).	Curcumin	11-19	interleukin 5	Mus musculus	165-169
28167853-10	2017	These findings indicate that curcumin can enhance postsynaptic electrical reactivity and cell viability in intact neural circuits with antidepressant-like effects, possibly through the upregulation of BDNF and reduction of inflammatory factors in the brain.	Curcumin	29-37	brain-derived neurotrophic factor	Rattus norvegicus	201-205
27830358-8	2017	Curcumin inhibited DNA methyltransferase 1 expression through down-regulation of transcription factor Sp1.	Curcumin	0-8	DNA methyltransferase 1	Homo sapiens	19-42
24779927-7	2014	Further investigations showed that curcumin inhibited VEGF expression in HSCs associated with disrupting platelet-derived growth factor-beta receptor (PDGF-betaR)/ERK and mTOR pathways.	Curcumin	35-43	vascular endothelial growth factor A	Rattus norvegicus	54-58
27830358-10	2017	In MDA-MB-361 cells, curcumin down-regulates the expression of Sp1 to inhibit the expression of DNA methyltransferase 1, thus subsequently reducing hypermethylation of DLC1 promoter to induce DLC1 expression.	Curcumin	21-29	DNA methyltransferase 1	Homo sapiens	96-119
27894084-3	2016	Previous evidences indicated that, the methylating transferase DNMT1 is downregulated by curcumin, and the transcription factor 21 (TCF21) is suppressed by DNMT1.	Curcumin	89-97	DNA methyltransferase 1	Homo sapiens	63-68
24983737-7	2014	Curcumin and Cur1 both protected SK-N-SH cells from Abeta1-42 and up-regulated the expression of hTERT.	Curcumin	0-8	telomerase reverse transcriptase	Homo sapiens	97-102
27894084-9	2016	We also demonstrated that DNMT1 expression was downregulated by curcumin.	Curcumin	64-72	DNA methyltransferase 1	Homo sapiens	26-31
24712702-0	2014	Effects of curcumin (Curcuma longa) on learning and spatial memory as well as cell proliferation and neuroblast differentiation in adult and aged mice by upregulating brain-derived neurotrophic factor and CREB signaling.	Curcumin	11-19	brain derived neurotrophic factor	Mus musculus	167-200
27894084-10	2016	Therefore, curcumin exerts its anti-cancer function by downregulating DNMT1, thereby upregulating TCF21.	Curcumin	11-19	DNA methyltransferase 1	Homo sapiens	70-75
27866850-5	2016	Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy.	Curcumin	22-30	COP9 signalosome subunit 5	Homo sapiens	14-18
27625050-7	2016	RESULTS: MiR-1275 and miR-1246 expression levels were up-regulated by curcumin.	Curcumin	70-78	microRNA 1275	Homo sapiens	9-17
27625050-11	2016	CONCLUSION: Collectively, our findings demonstrate that curcumin inhibited HUVEC proliferation by up-regulation of miR-1275 and miR-1246.	Curcumin	56-64	microRNA 1275	Homo sapiens	115-123
28105120-0	2016	Effects of curcumin on the apoptosis of cardiomyocytes and the expression of NF-kappaB, PPAR-gamma and Bcl-2 in rats with myocardial infarction injury.	Curcumin	11-19	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	88-98
24735534-2	2014	In cultured WM-115 melanoma cells, curcumin induced mitochondrial membrane potential (MPP) decrease, cyclophilin-D (CyPD)-adenine nucleotide translocator 1 (ANT-1) (two mPTP components) mitochondrial association and cytochrome C release, indicating mPTP opening.	Curcumin	35-43	solute carrier family 25 member 4	Homo sapiens	157-162
24735534-3	2014	The mPTP blocker sanglifehrin A (SfA) and ANT-1 siRNA-depletion dramatically inhibited curcumin-induced cytochrome C release and WM-115 cell death.	Curcumin	87-95	solute carrier family 25 member 4	Homo sapiens	42-47
23943298-7	2014	Expression of ikappaB was elevated in PC9 cells by curcumin administration, and pretreatment with siRNAs for ikappaB significantly attenuated the reduction in cell viability after coadministration of erlotinib and curcumin.	Curcumin	51-59	proprotein convertase subtilisin/kexin type 9	Homo sapiens	38-41
28105120-7	2016	The immunohistochemical assay demonstrated that curcumin treatment inhibited the expression of NF-kappaB, but increased the expression of PPAR-gamma.	Curcumin	48-56	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	138-148
28105120-9	2016	Therefore, curcumin antagonizes cardiomyocyte apoptosis and inhibits inflammatory cell infiltration following myocardial infarction, which may be associated with its inhibitory effects on the expression of NF-kappaB, and activating effects on the expression of PPAR-gamma and Bcl-2 in myocardial cells.	Curcumin	11-19	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	261-271
24599958-2	2014	Curcumin, a common ingredient of Asian spices, is known to disrupt Abeta fibril formation and to reduce AD pathology in mouse models.	Curcumin	0-8	amyloid beta (A4) precursor protein	Mus musculus	67-72
27697644-6	2016	A subset of these compounds, such as curcumin and resveratrol, affect multiple epigenetic processes, including DNMT inhibition, HDAC inactivation, MBP suppression, HAT activation, and microRNA modulation.	Curcumin	37-45	DNA methyltransferase 1	Homo sapiens	111-115
27831561-4	2016	Therefore, we examined the effect of n-3 PUFA and polyphenol (curcumin) combination on Lgr5+ stem cells during tumor initiation and progression in the colon compared with an n-6 PUFA-enriched control diet.	Curcumin	62-70	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	87-91
27831561-7	2016	Only n-3 PUFA+curcumin feeding reduced nuclear beta-catenin in aberrant crypt foci (by threefold) compared with control at the progression time point.	Curcumin	14-22	catenin (cadherin associated protein), beta 1	Mus musculus	47-59
27831561-8	2016	n-3 PUFA+curcumin synergistically increased targeted apoptosis in DNA-damaged Lgr5+ stem cells by 4.5-fold compared with control at 12 h and maximally reduced damaged Lgr5+ stem cells at 24 h, down to the level observed in saline-treated mice.	Curcumin	9-17	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	78-82
27831561-8	2016	n-3 PUFA+curcumin synergistically increased targeted apoptosis in DNA-damaged Lgr5+ stem cells by 4.5-fold compared with control at 12 h and maximally reduced damaged Lgr5+ stem cells at 24 h, down to the level observed in saline-treated mice.	Curcumin	9-17	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	167-171
27831561-9	2016	Finally, RNAseq analysis indicated that p53 signaling in Lgr5+ stem cells from mice exposed to AOM was uniquely upregulated only following n-3 PUFA+curcumin cotreatment.	Curcumin	148-156	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	57-61
27629417-12	2016	Experiments with LPS-activated bone marrow-derived macrophages from wild-type and GILZ knock-out mice demonstrated that curcumin inhibits the activity of inflammatory regulators, such as NF-kappaB or ERK, and subsequent TNF-alpha production via GILZ.	Curcumin	120-128	TSC22 domain family, member 3	Mus musculus	82-86
24743574-0	2014	Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability.	Curcumin	0-8	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	206-211
27629417-12	2016	Experiments with LPS-activated bone marrow-derived macrophages from wild-type and GILZ knock-out mice demonstrated that curcumin inhibits the activity of inflammatory regulators, such as NF-kappaB or ERK, and subsequent TNF-alpha production via GILZ.	Curcumin	120-128	TSC22 domain family, member 3	Mus musculus	245-249
27629417-13	2016	In summary, our data indicate that HuR-dependent GILZ induction contributes to the anti-inflammatory properties of curcumin.	Curcumin	115-123	TSC22 domain family, member 3	Mus musculus	49-53
27626169-0	2016	The putative oncotarget CSN5 controls a transcription-uncorrelated p53-mediated autophagy implicated in cancer cell survival under curcumin treatment.	Curcumin	131-139	COP9 signalosome subunit 5	Homo sapiens	24-28
27626169-2	2016	The COP9 signalosome (CSN) component CSN5, a known specific target for curcumin, can control p53 stability by increasing its degradation through ubiquitin system.	Curcumin	71-79	COP9 signalosome subunit 5	Homo sapiens	37-41
27626169-3	2016	But the correlation of CSN5-controlled p53 to anticancer therapeutic effect of curcumin is currently unknown.	Curcumin	79-87	COP9 signalosome subunit 5	Homo sapiens	23-27
24743574-7	2014	Co-treatment with curcumin and NVP-BEZ235 led to the down-regulation of Mcl-1 protein expression but not mRNA expression.	Curcumin	18-26	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	72-77
27626169-4	2016	Here we showed that CSN5-controlled p53 was transcriptional inactive and responsible for autophagy in human normal BJ cells and cancer HepG2 cells under curcumin treatment.	Curcumin	153-161	COP9 signalosome subunit 5	Homo sapiens	20-24
27626169-5	2016	Of note, CSN5-initiated cellular autophagy by curcumin treatment was abolished in p53-null HCT116p53-/- cancer cells, which could be rescued by reconstitution with wild-type p53 or transcription inactive p53 mutant p53R273H.	Curcumin	46-54	COP9 signalosome subunit 5	Homo sapiens	9-13
24743574-8	2014	Ectopic expression of Mcl-1 completely inhibited curcumin plus NVP-NEZ235-induced apoptosis.	Curcumin	49-57	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	22-27
27626169-6	2016	Furthermore, CSN5-controlled p53 conferred a pro-survival autophagy in diverse cancer cells response to curcumin.	Curcumin	104-112	COP9 signalosome subunit 5	Homo sapiens	13-17
20818711-3	2010	The conjugation potential was inhibited dose dependently with curcumin, an inhibitor of GSTs.	Curcumin	62-70	glutathione S-transferase, alpha 3	Mus musculus	88-92
20403340-10	2010	Treatment with curcumin either 1h before or immediately after LPS injection significantly ameliorated white matter injury and loss of preOLs, decreased activated microglia, and inhibited microglial expression of iNOS and translocation of p67phox and gp91phox to the microglial cell membranes in neonatal rat brains following LPS injection.	Curcumin	15-23	cytochrome b-245 beta chain	Rattus norvegicus	250-258
24316375-0	2014	Evaluation of (arene)Ru(II) complexes of curcumin as inhibitors of dipeptidyl peptidase IV.	Curcumin	41-49	dipeptidyl peptidase 4	Homo sapiens	67-90
24316375-8	2014	Collectively, our results demonstrate that the complexation of curcumin with ruthenium(II) could be a promising starting point for the development of curcumin-based DPPIV inhibitors.	Curcumin	63-71	dipeptidyl peptidase 4	Homo sapiens	165-170
20484172-10	2010	RESULTS: In the curcumin-treated group, CYP1A2 activity was decreased by 28.6% (95% CI 15.6 to 41.8; p &lt; 0.000), while increases were observed in CYP2A6 (by 48.9%; 95% CI 25.3 to 72.4; p &lt; 0.000).	Curcumin	16-24	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	149-155
20484172-15	2010	CONCLUSIONS: The results indicated that curcumin inhibits CYP1A2 function but enhances CYP2A6 activity.	Curcumin	40-48	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	87-93
27318975-4	2016	According to results of SAR study, it was found that 3,4-dihydropyrimidines of curcumin, 2c, 2d, 2j and 2n exhibited better antioxidant activity than curcumin.	Curcumin	79-87	sarcosine dehydrogenase	Homo sapiens	24-27
24316375-8	2014	Collectively, our results demonstrate that the complexation of curcumin with ruthenium(II) could be a promising starting point for the development of curcumin-based DPPIV inhibitors.	Curcumin	150-158	dipeptidyl peptidase 4	Homo sapiens	165-170
27318975-4	2016	According to results of SAR study, it was found that 3,4-dihydropyrimidines of curcumin, 2c, 2d, 2j and 2n exhibited better antioxidant activity than curcumin.	Curcumin	150-158	sarcosine dehydrogenase	Homo sapiens	24-27
20132469-0	2010	Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4?	Curcumin	0-8	aquaporin 4	Mus musculus	97-108
20132469-5	2010	Curcumin also reversed the induction of aquaporin-4, an astrocytic water channel implicated in the development of cellular edema following head trauma.	Curcumin	0-8	aquaporin 4	Mus musculus	40-51
23666561-10	2014	RESULTS: Compared with the control, curcumin reduced uterine leiomyosarcoma tumor volume and mass significantly with a concordant decrease in mTOR and S6 phosphorylation.	Curcumin	36-44	mechanistic target of rapamycin kinase	Mus musculus	142-146
20132469-6	2010	Notably, curcumin blocked IL-1beta-induced aquaporin-4 expression in cultured astrocytes, an effect mediated, at least in part, by reduced activation of the p50 and p65 subunits of nuclear factor kappaB.	Curcumin	9-17	aquaporin 4	Mus musculus	43-54
23666561-14	2014	CONCLUSION: Curcumin inhibited uterine leiomyosarcoma tumor growth in vivo by targeting the AKT-mTOR pathway for inhibition.	Curcumin	12-20	mechanistic target of rapamycin kinase	Mus musculus	96-100
20407012-4	2010	BA, curcumin, and iSp also decreased phosphorylation of Akt in these cells, and downregulation of EGFR by BA, curcumin, and iSp was accompanied by induction of LC3 and autophagy, which is consistent with recent studies showing that EGFR suppresses autophagic cell death.	Curcumin	110-118	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	160-163
27424491-6	2016	Treatment with curcumin, a c-Jun inhibitor, or stable knockdown of c-Jun abrogates TGF-beta-induced Claudin-4 expression suggesting an involvement of the c-Jun pathway.	Curcumin	15-23	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-32
24460581-11	2014	The curcumin treatment significantly prevented the ischemia-reperfusion-induced elevation of nitrite/nitrate and TNF-alpha.	Curcumin	4-12	tumor necrosis factor	Oryctolagus cuniculus	113-122
27456358-4	2016	The first stage of our studies showed that curcumin affected the expression of miR-33b, which, in turn, affected the expression of the X-linked inhibitor of apoptosis protein (XIAP) messenger RNA (mRNA).	Curcumin	43-51	X-linked inhibitor of apoptosis	Homo sapiens	135-174
27456358-4	2016	The first stage of our studies showed that curcumin affected the expression of miR-33b, which, in turn, affected the expression of the X-linked inhibitor of apoptosis protein (XIAP) messenger RNA (mRNA).	Curcumin	43-51	X-linked inhibitor of apoptosis	Homo sapiens	176-180
27456358-8	2016	The results showed that curcumin had similar effects on cell growth and apoptosis as the upregulation of miR-33b and the upregulation of the siRNA of XIAP.	Curcumin	24-32	X-linked inhibitor of apoptosis	Homo sapiens	150-154
27456358-9	2016	The results that followed from the restore experiments showed that curcumin affected cell growth and apoptosis presumably by upregulating the XIAP targeting in gastric cancer.	Curcumin	67-75	X-linked inhibitor of apoptosis	Homo sapiens	142-146
27456358-10	2016	Collectively, our results indicate that curcumin-miR-33b-XIAP coupling might be an important mechanism by which curcumin induces the apoptosis of SGC-7901 and BGC-823 cells.	Curcumin	40-48	X-linked inhibitor of apoptosis	Homo sapiens	57-61
27456358-10	2016	Collectively, our results indicate that curcumin-miR-33b-XIAP coupling might be an important mechanism by which curcumin induces the apoptosis of SGC-7901 and BGC-823 cells.	Curcumin	112-120	X-linked inhibitor of apoptosis	Homo sapiens	57-61
27502306-7	2016	Similarly, ALP activity and expression of bone-related molecules including Runx2, BMP2, and Osterix were also decreased in VSMCs treated with curcumin.	Curcumin	142-150	PDZ and LIM domain 3	Rattus norvegicus	11-14
27502306-7	2016	Similarly, ALP activity and expression of bone-related molecules including Runx2, BMP2, and Osterix were also decreased in VSMCs treated with curcumin.	Curcumin	142-150	Sp7 transcription factor	Rattus norvegicus	92-99
20346917-0	2010	Curcumin dramatically enhances retinoic acid-induced superoxide generating activity via accumulation of p47-phox and p67-phox proteins in U937 cells.	Curcumin	0-8	neutrophil cytosolic factor 1	Homo sapiens	104-112
20056776-6	2010	The animals that received curcumin alone orally or in combination with augmentin, 15 days prior to bacterial instillation into the lungs via the intranasal route, showed a significant (P &lt;0.05) decrease in neutrophil influx into the lungs and a significant (P &lt;0.05) decrease in the production of MDA, NO, MPO activity and TNF-alpha levels.	Curcumin	26-34	myeloperoxidase	Mus musculus	312-315
19878610-0	2010	Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease.	Curcumin	0-8	interleukin 10	Homo sapiens	130-135
19878610-9	2010	Our aim was to assess the effect of curcumin on key disease mediators p38 mitogen-activated protein kinase (MAPK), IL-1beta, IL-10 and matrix metalloproteinase-3 (MMP-3) in the gut of children and adults with IBD.	Curcumin	36-44	interleukin 10	Homo sapiens	125-130
27551266-11	2016	Curcumin-resveratrol co-treatment prevented B(a)P induced nuclear translocation of AhR and CYP1A1 (Cytochrome P4501A1) expression.	Curcumin	0-8	aryl hydrocarbon receptor	Rattus norvegicus	83-86
24288129-5	2014	Curcumin stimulated the release of cholesterol and the lysosomal beta-hexosaminidase enzyme, as well as the exosome markers, flotillin-2 and CD63.	Curcumin	0-8	CD63 molecule	Homo sapiens	141-145
27525306-9	2016	Finally, in the experimental mouse model, we showed that curcumin inhibited HGF-stimulated tumor growth and induced an increase in E-cadherin expression and a decrease in vimentin, CD34, and vascular endothelial growth factor (VEGF) expression.	Curcumin	57-65	hepatocyte growth factor	Mus musculus	76-79
27525306-9	2016	Finally, in the experimental mouse model, we showed that curcumin inhibited HGF-stimulated tumor growth and induced an increase in E-cadherin expression and a decrease in vimentin, CD34, and vascular endothelial growth factor (VEGF) expression.	Curcumin	57-65	vimentin	Mus musculus	171-179
27525306-9	2016	Finally, in the experimental mouse model, we showed that curcumin inhibited HGF-stimulated tumor growth and induced an increase in E-cadherin expression and a decrease in vimentin, CD34, and vascular endothelial growth factor (VEGF) expression.	Curcumin	57-65	vascular endothelial growth factor A	Mus musculus	191-225
27525306-9	2016	Finally, in the experimental mouse model, we showed that curcumin inhibited HGF-stimulated tumor growth and induced an increase in E-cadherin expression and a decrease in vimentin, CD34, and vascular endothelial growth factor (VEGF) expression.	Curcumin	57-65	vascular endothelial growth factor A	Mus musculus	227-231
20160040-3	2010	Here we report that an inhibitory activity of curcumin on the antioxidant enzyme thioredoxin reductase-1 (TxnRd1) is required for curcumin-mediated radiosensitization of squamous carcinoma cells.	Curcumin	130-138	thioredoxin reductase 1	Homo sapiens	81-104
20160040-3	2010	Here we report that an inhibitory activity of curcumin on the antioxidant enzyme thioredoxin reductase-1 (TxnRd1) is required for curcumin-mediated radiosensitization of squamous carcinoma cells.	Curcumin	130-138	thioredoxin reductase 1	Homo sapiens	106-112
20160040-4	2010	Stable knockdown of TxnRd1 in both HeLa and FaDu cells nearly abolished curcumin-mediated radiosensitization.	Curcumin	72-80	thioredoxin reductase 1	Homo sapiens	20-26
20160040-5	2010	TxnRd1 knockdown cells showed decreased radiation-induced reactive oxygen species and sustained extracellular signal-regulated kinase 1/2 activation, which we previously showed was required for curcumin-mediated radiosensitization.	Curcumin	194-202	thioredoxin reductase 1	Homo sapiens	0-6
20160040-6	2010	Conversely, overexpressing catalytically active TxnRd1 in HEK293 cells, with low basal levels of TxnRd1, increased their sensitivity to curcumin alone and to the combination of curcumin and ionizing radiation.	Curcumin	136-144	thioredoxin reductase 1	Homo sapiens	48-54
24503718-7	2014	Curcumin enhanced SAS/luc radiosensitivity through the inhibition of radiation-induced NF-kappaB activity and expression of effector proteins both in vitro and in vivo.	Curcumin	0-8	tetraspanin 31	Homo sapiens	18-21
20160040-6	2010	Conversely, overexpressing catalytically active TxnRd1 in HEK293 cells, with low basal levels of TxnRd1, increased their sensitivity to curcumin alone and to the combination of curcumin and ionizing radiation.	Curcumin	136-144	thioredoxin reductase 1	Homo sapiens	97-103
20160040-6	2010	Conversely, overexpressing catalytically active TxnRd1 in HEK293 cells, with low basal levels of TxnRd1, increased their sensitivity to curcumin alone and to the combination of curcumin and ionizing radiation.	Curcumin	177-185	thioredoxin reductase 1	Homo sapiens	48-54
20160040-7	2010	These results show the critical role of TxnRd1 in curcumin-mediated radiosensitization and suggest that TxnRd1 levels in tumors could have clinical value as a predictor of response to curcumin and radiotherapy.	Curcumin	50-58	thioredoxin reductase 1	Homo sapiens	40-46
20160040-7	2010	These results show the critical role of TxnRd1 in curcumin-mediated radiosensitization and suggest that TxnRd1 levels in tumors could have clinical value as a predictor of response to curcumin and radiotherapy.	Curcumin	184-192	thioredoxin reductase 1	Homo sapiens	104-110
19788403-12	2010	It is thought that this effect may have occurred via curcumin and TCDD were binding aryl hydrocarbon receptor (AhR) competitively.	Curcumin	53-61	aryl hydrocarbon receptor	Rattus norvegicus	84-109
19788403-12	2010	It is thought that this effect may have occurred via curcumin and TCDD were binding aryl hydrocarbon receptor (AhR) competitively.	Curcumin	53-61	aryl hydrocarbon receptor	Rattus norvegicus	111-114
20127004-7	2010	Results from Western blotting showed that curcumin inhibited the protein levels of PKC, FAK, NF-kappaB p65 and Rho A leading to the inhibition of ERK1/2, MKK7, COX-2 and ROCK1, respectively, finally causing the inhibition of MMP-2 and -9 for the inhibition of migration and invasion of N18 cells.	Curcumin	42-50	ras homolog family member A	Rattus norvegicus	111-116
27124646-2	2016	Curcumin is a potential anticancer agent with p-glycoprotein (p-gp) inhibiting activity may be co-administered with docetaxel as a nanosuspension to enhance its anticancer effect by increasing the oral bioavailability and decreasing drug efflux.	Curcumin	0-8	phosphoglycolate phosphatase	Mus musculus	46-60
24342046-9	2014	Curcumin treatment greatly decreased the levels of c-Jun, c-Fos, SphK1, and FN in the kidney tissues of diabetic rats.	Curcumin	0-8	fibronectin 1	Rattus norvegicus	76-78
27124646-2	2016	Curcumin is a potential anticancer agent with p-glycoprotein (p-gp) inhibiting activity may be co-administered with docetaxel as a nanosuspension to enhance its anticancer effect by increasing the oral bioavailability and decreasing drug efflux.	Curcumin	0-8	phosphoglycolate phosphatase	Mus musculus	62-66
27124646-10	2016	CONCLUSIONS: The in vitro and in vivo study of the nanosuspensions has shown that Co-administration of Curcumin as a p-gp inhibitor with docetaxel may have the potential to increase the anti-breast cancer efficacy of both drugs.	Curcumin	103-111	phosphoglycolate phosphatase	Mus musculus	117-121
27260322-9	2016	RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta.	Curcumin	14-22	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)	Mus musculus	180-187
27260322-9	2016	RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta.	Curcumin	55-63	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)	Mus musculus	180-187
27026405-9	2016	Curcumin inhibited the expression of XRCC1 in cisplatin-exposed NSCLC cells.	Curcumin	0-8	X-ray repair cross complementing 1	Homo sapiens	37-42
27026405-10	2016	Furthermore, transfection with constitutive active MKK6 or HA-p38 MAPK vectors rescued the XRCC1 protein level and also the cell survival suppressed by cisplatin and curcumin combination in A549 and H1703 cells.	Curcumin	166-174	X-ray repair cross complementing 1	Homo sapiens	91-96
27026405-11	2016	These findings suggested that the downregulation of XRCC1 expression by curcumin can enhance the chemosensitivity of cisplatin in NSCLC cells.	Curcumin	72-80	X-ray repair cross complementing 1	Homo sapiens	52-57
26985708-10	2016	Curcumin also inhibited tumor metastasis by downregulating the expression of CXCR4 significantly.	Curcumin	0-8	C-X-C motif chemokine receptor 4	Homo sapiens	77-82
27012210-0	2016	Curcumin suppresses 4-hydroxytamoxifen resistance in breast cancer cells by targeting SLUG/Hexokinase 2 pathway.	Curcumin	0-8	snail family transcriptional repressor 2	Homo sapiens	86-90
27012210-3	2016	4-hydroxytamoxifen (4-OHT) promoted SLUG expression, which was blocked by curcumin.	Curcumin	74-82	snail family transcriptional repressor 2	Homo sapiens	36-40
27012210-7	2016	Combination of curcumin and 4-OHT suppressed SLUG and HK2 expression, leading to mitochondrion-mediated apoptosis.	Curcumin	15-23	snail family transcriptional repressor 2	Homo sapiens	45-49
20127004-7	2010	Results from Western blotting showed that curcumin inhibited the protein levels of PKC, FAK, NF-kappaB p65 and Rho A leading to the inhibition of ERK1/2, MKK7, COX-2 and ROCK1, respectively, finally causing the inhibition of MMP-2 and -9 for the inhibition of migration and invasion of N18 cells.	Curcumin	42-50	mitogen activated protein kinase kinase 7	Rattus norvegicus	154-158
20127004-7	2010	Results from Western blotting showed that curcumin inhibited the protein levels of PKC, FAK, NF-kappaB p65 and Rho A leading to the inhibition of ERK1/2, MKK7, COX-2 and ROCK1, respectively, finally causing the inhibition of MMP-2 and -9 for the inhibition of migration and invasion of N18 cells.	Curcumin	42-50	Rho-associated coiled-coil containing protein kinase 1	Rattus norvegicus	170-175
20697527-2	2010	A recent paper by Rowe et al described that curcumin induced DNA damage in triple negative breast cancer cells and regulated BRCA1 protein expression and modification.1 Related research and potential use of curcumin will be discussed in this article.	Curcumin	44-52	BRCA1 DNA repair associated	Homo sapiens	125-130
20697527-2	2010	A recent paper by Rowe et al described that curcumin induced DNA damage in triple negative breast cancer cells and regulated BRCA1 protein expression and modification.1 Related research and potential use of curcumin will be discussed in this article.	Curcumin	207-215	BRCA1 DNA repair associated	Homo sapiens	125-130
20332435-0	2010	Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R.	Curcumin	0-8	insulin like growth factor 1 receptor	Homo sapiens	81-87
20332435-5	2010	However, inclusion of curcumin to continued FOLFOX treatment for another 48 h greatly reduced the survival of these cells, accompanied by a concomitant reduction in activation of EGFR, HER-2, IGF-1R and AKT, as well as expression of COX-2 and cyclin-D1.	Curcumin	22-30	insulin like growth factor 1 receptor	Homo sapiens	192-198
20121547-0	2010	Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and downregulation of survivin/BIRC5 gene expression.	Curcumin	0-8	baculoviral IAP repeat containing 5	Homo sapiens	122-127
24741455-10	2014	Annexin V staining followed by flow cytometric analysis demonstrated that curcumin treatment enhanced the docetaxel-induced apoptosis of ATC cells.	Curcumin	74-82	annexin A5	Homo sapiens	0-9
19447587-0	2010	Curcumin prevents human aortic smooth muscle cells migration by inhibiting of MMP-9 expression.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	78-83
19447587-6	2010	The results indicated that curcumin inhibited MMP-9 activity and expression.	Curcumin	27-35	matrix metallopeptidase 9	Homo sapiens	46-51
19447587-8	2010	CONCLUSION: These results indicate that curcumin has anti-inflammatory properties and may prevent the migration of HASMCs by suppressing MMP-9 expression through down-regulation of NF-kappaB.	Curcumin	40-48	matrix metallopeptidase 9	Homo sapiens	137-142
26991801-0	2016	Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1.	Curcumin	63-71	translocating chain-associating membrane protein 1	Mus musculus	45-50
26991801-1	2016	It has previously been shown that curcumin can effectively inhibit prostate cancer proliferation and progression in TRAMP mice, potentially acting through the hypomethylation of the Nrf2 gene promoter and hence activation of the Nrf2 pathway to enhance cell antioxidative defense.	Curcumin	34-42	translocating chain-associating membrane protein 1	Mus musculus	116-121
24380633-5	2014	In addition, cell cycle assays on a KHOS cell line after treatment revealed that curcumin only liposomes induced G2/M arrest by upregulation of cyclin B1, while C6 only liposomes induced G1 arrest by downregulation of cyclin D1.	Curcumin	81-89	cyclin B1	Homo sapiens	144-153
27091625-5	2016	Transcriptomic profiling revealed the up-regulation of three NF-kappaB-regulated CXC-chemokines, CXCL8, CXCL1 and CXCL2, in the resistant cells that were more efficiently down-regulated after OXA + Curcumin treatment as compared to the sensitive cells.	Curcumin	198-206	C-X-C motif chemokine ligand 1	Homo sapiens	104-109
27091625-7	2016	High expression of CXCL1 in FFPE samples from explant cultures of CRC patients-derived liver metastases was associated with response to OXA + Curcumin.	Curcumin	142-150	C-X-C motif chemokine ligand 1	Homo sapiens	19-24
27091625-8	2016	In conclusion, we suggest that combination of OXA + Curcumin could be an effective treatment, for which CXCL1 could be used as a predictive marker, in CRC patients.	Curcumin	52-60	C-X-C motif chemokine ligand 1	Homo sapiens	104-109
24380633-6	2014	C6-curcumin liposomes induced G2/M arrest and showed a combined effect in the expression levels of cyclin D1 and cyclin B1.	Curcumin	3-11	cyclin B1	Homo sapiens	113-122
26978516-6	2016	Furthermore, curcumin significantly increased key mRNA levels of HK2, PKM2, LDHA, CES, Cpt1, Cpt2, FASN, and ATP5b and decreased levels of GLUT2 and ACC1 to enhance glycolysis and inhibit lipid metabolism and TCA cycle.	Curcumin	13-21	hexokinase 2	Rattus norvegicus	65-68
24415068-8	2014	The analysis on anion transport markers (OAT1 and OAT3) showed a similar trend (CDF &gt; curcumin).	Curcumin	89-97	solute carrier family 22 member 8	Rattus norvegicus	50-54
26978516-6	2016	Furthermore, curcumin significantly increased key mRNA levels of HK2, PKM2, LDHA, CES, Cpt1, Cpt2, FASN, and ATP5b and decreased levels of GLUT2 and ACC1 to enhance glycolysis and inhibit lipid metabolism and TCA cycle.	Curcumin	13-21	carnitine palmitoyltransferase 2	Rattus norvegicus	93-97
26796656-0	2016	A new crystal form of human transthyretin obtained with a curcumin derived ligand.	Curcumin	58-66	transthyretin	Homo sapiens	28-41
24291100-7	2014	Treatment with leflunomide, perindopril or curcumin alone abrogated the DEN-induced increased MVD as well as the elevated expression of VEGF, while only curcumin inhibited HIF-1alpha hepatic expression.	Curcumin	153-161	hypoxia inducible factor 1, alpha subunit	Mus musculus	172-182
26608718-0	2016	Effect of curcumin on serum brain-derived neurotrophic factor levels in women with premenstrual syndrome: A randomized, double-blind, placebo-controlled trial.	Curcumin	10-18	brain derived neurotrophic factor	Homo sapiens	28-61
26608718-4	2016	Studies of last decade revealed neuroprotective effects of curcumin and its ability to increase BDNF levels.	Curcumin	59-67	brain derived neurotrophic factor	Homo sapiens	96-100
26608718-5	2016	In the present study, we evaluated the effect of curcumin on serum BDNF level and PMS symptoms severity in women with PMS.	Curcumin	49-57	brain derived neurotrophic factor	Homo sapiens	67-71
26608718-14	2016	But in curcumin group first, second and third cycles after interventions BDNF levels were significantly higher and mean scores of PMS symptoms were significantly less than placebo group.	Curcumin	7-15	brain derived neurotrophic factor	Homo sapiens	73-77
26608718-15	2016	Based on our results part of these beneficial effects of curcumin may be mediated through enhancing serum BDNF levels in women with PMS.	Curcumin	57-65	brain derived neurotrophic factor	Homo sapiens	106-110
24422903-2	2014	This study aims to investigate the effects of a novel curcumin derivative (NCD) on JNK signaling pathway on insulin synthesis and secretion in streptozotocin (STZ)-treated rat pancreatic islets in vitro.	Curcumin	54-62	mitogen-activated protein kinase 8	Rattus norvegicus	83-86
26732833-10	2016	RESULTS: Administration of curcumin decreased TNF-alpha, TNFR2, and caspase 8 without affecting TNFR1 levels.	Curcumin	27-35	caspase 8	Rattus norvegicus	68-77
26732833-12	2016	CONCLUSIONS: The cytoprotective role of curcumin relies on its ability to decrease the TNFR2 mRNA and enhance the antiapoptotic molecules RIP and TRAF2 to decrease the apoptotic pathway via decreasing the caspase 8.	Curcumin	40-48	receptor interacting serine/threonine kinase 1	Rattus norvegicus	138-141
26732833-12	2016	CONCLUSIONS: The cytoprotective role of curcumin relies on its ability to decrease the TNFR2 mRNA and enhance the antiapoptotic molecules RIP and TRAF2 to decrease the apoptotic pathway via decreasing the caspase 8.	Curcumin	40-48	caspase 8	Rattus norvegicus	205-214
26833194-0	2016	GADD45alpha modulates curcumin sensitivity through c-Abl- and JNK-dependent signaling pathways in a mismatch repair-dependent manner.	Curcumin	22-30	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	51-65
26833194-9	2016	Moreover, inhibition of Abl through ST571 treatment and its downstream effector JNK through SP600125 treatment blocked GADD45alpha upregulation and cell death triggered by curcumin.	Curcumin	172-180	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	24-27
26833194-10	2016	Collective results lead us to conclude that GADD45alpha modulates curcumin sensitivity through activation of c-Abl &gt; JNK signaling in a mismatch repair-dependent manner.	Curcumin	66-74	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	109-114
24184218-8	2014	The in vitro permeation of curcumin through gastric mucin gel layer affirmed the capability of microsponges to deliver drug across mucin r and reach the target site to treat gastric cancer.	Curcumin	27-35	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	44-57
26893544-8	2016	Curcumin modified the cytotoxic action of etoposide in HL-60 cells through intensification of free radical production because preincubation with N-acetyl-l-cysteine (NAC) significantly reduced the cytotoxic effect of curcumin itself and a combination of two compounds.	Curcumin	0-8	X-linked Kx blood group	Homo sapiens	166-169
26893544-8	2016	Curcumin modified the cytotoxic action of etoposide in HL-60 cells through intensification of free radical production because preincubation with N-acetyl-l-cysteine (NAC) significantly reduced the cytotoxic effect of curcumin itself and a combination of two compounds.	Curcumin	217-225	X-linked Kx blood group	Homo sapiens	166-169
24401215-3	2014	Our earlier observations suggest that curcumin"s suppression of atherogenesis might be mediated through changes in aP2 and CD36 expression in macrophages.	Curcumin	38-46	fatty acid binding protein 4, adipocyte	Mus musculus	115-118
26607901-0	2016	Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum Ca2+ ATPase activity in ovarian cancer cells.	Curcumin	0-8	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	41-80
24401215-19	2014	One of the mechanisms by which low dose curcumin modulates atherogenesis is through suppression of aP2 and CD36 expression in macrophages, which are the key players in atherogenesis.	Curcumin	40-48	fatty acid binding protein 4, adipocyte	Mus musculus	99-102
24211897-0	2014	Effect of curcumin on down-expression of thrombospondin-4 induced by oxidized low-density lipoprotein in mouse macrophages.	Curcumin	10-18	thrombospondin 4	Mus musculus	41-57
25596714-16	2016	Concurrently, RhoA and ROCK activities and expression levels of RhoA, ROCK1, ROCK2, MMP2 and MMP9 were down-regulated by curcumin in a concentration-dependent manner.	Curcumin	121-129	matrix metallopeptidase 9	Homo sapiens	93-97
25385666-6	2016	In contrast, higher hepatic contents of glutathione, heme oxygenase-1 and superoxide dismutase were observed in rats with curcumin.	Curcumin	122-130	heme oxygenase 1	Rattus norvegicus	53-69
26648392-7	2016	Mechanistic studies demonstrated that curcumin significantly restored the expression levels of heme oxygenase-1 and NAD(P)H: quinone oxidoreductase 1, thus ameliorating ROT-induced damage in vivo, via the phosphorylation of Akt and nuclear factor erythroid 2-related factor 2 (Nrf2).	Curcumin	38-46	heme oxygenase 1	Rattus norvegicus	95-111
24211897-1	2014	This study was designed to investigate the effect of curcumin on the expression of thrombospondin-4 (THBS-4) in mouse macrophages treated with oxidized low-density lipoprotein (oxLDL).	Curcumin	53-61	thrombospondin 4	Mus musculus	83-99
24211897-1	2014	This study was designed to investigate the effect of curcumin on the expression of thrombospondin-4 (THBS-4) in mouse macrophages treated with oxidized low-density lipoprotein (oxLDL).	Curcumin	53-61	thrombospondin 4	Mus musculus	101-107
26623679-5	2016	Moreover, our findings demonstrate that relatively low concentrations of either sulforaphane or curcumin significantly (P &lt; .05) increase NQO1 protein expression and activity without triggering G2/M cell cycle arrest or mitotic catastrophe.	Curcumin	96-104	NAD(P)H dehydrogenase, quinone 1	Mus musculus	141-145
24211897-6	2014	MTT assay showed that curcumin concentrations up to 25 muM and oxLDL concentrations up to 20 mug/ml had no significant cytotoxic effects on macrophages at 24 h. Real-time quantitative PCR revealed that THBS-4 mRNA expression was markedly reduced by stimulation with oxLDL, but subsequently significantly increased by treatment with curcumin.	Curcumin	332-340	thrombospondin 4	Mus musculus	202-208
24211897-7	2014	Western blotting confirmed that curcumin (5, 15, and 25 muM) significantly prevented the decrease in THBS-4 expression induced by oxLDL (20 mug/ml) in macrophages.	Curcumin	32-40	thrombospondin 4	Mus musculus	101-107
24211897-8	2014	Curcumin prevents the decrease in THBS-4 expression induced by oxLDL, which may represent one of the anti-atherosclerotic mechanisms of curcumin.	Curcumin	0-8	thrombospondin 4	Mus musculus	34-40
24211897-8	2014	Curcumin prevents the decrease in THBS-4 expression induced by oxLDL, which may represent one of the anti-atherosclerotic mechanisms of curcumin.	Curcumin	136-144	thrombospondin 4	Mus musculus	34-40
24138392-7	2014	Only DNA methyltransferase 3b (DNMT3b) was reduced in vivo and in vitro after curcumin treatment.	Curcumin	78-86	DNA methyltransferase 3 beta	Homo sapiens	31-37
28569571-0	2016	Curcumin inhibits oxidative stress-induced TRPM2 channel activation, calcium ion entry and apoptosis values in SH-SY5Y neuroblastoma cells: Involvement of transfection procedure.	Curcumin	0-8	transient receptor potential cation channel subfamily M member 2	Homo sapiens	43-48
28569571-11	2016	In conclusion, curcumin strongly induces modulator effects on TRPM2-mediated Ca2+ influx caused by ROS and caspase 3 and 9 processes in SH-SY5Y neuroblastoma cells.	Curcumin	15-23	transient receptor potential cation channel subfamily M member 2	Homo sapiens	62-67
24138392-8	2014	Further studies were performed aiming to confirm that the knockdown of DNMT3b enhanced the loss of PTEN methylation by curcumin.	Curcumin	119-127	DNA methyltransferase 3 beta	Homo sapiens	71-77
26884838-6	2015	The further evidence showed that curcumin supplement significantly decreased the TRAP-positive stained area and inhibited the activity of OPG/RANKL/RANK signaling in the GIOP mice.	Curcumin	33-41	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	138-141
24138392-8	2014	Further studies were performed aiming to confirm that the knockdown of DNMT3b enhanced the loss of PTEN methylation by curcumin.	Curcumin	119-127	phosphatase and tensin homolog	Homo sapiens	99-103
26498137-9	2015	In addition, curcumin was found to cause the induction of p21, a cyclin-dependent kinase inhibitor, and reduction of X-linked inhibitor of apoptosis protein (XIAP), an anti-apoptotic molecule, in parental H460 cells as well as chemoresistant cells, H460/CisR and H460/TR.	Curcumin	13-21	X-linked inhibitor of apoptosis	Homo sapiens	117-156
24138392-9	2014	In addition, miR-29b was involved in the hypomethylation of PTEN by curcumin.	Curcumin	68-76	phosphatase and tensin homolog	Homo sapiens	60-64
26498137-9	2015	In addition, curcumin was found to cause the induction of p21, a cyclin-dependent kinase inhibitor, and reduction of X-linked inhibitor of apoptosis protein (XIAP), an anti-apoptotic molecule, in parental H460 cells as well as chemoresistant cells, H460/CisR and H460/TR.	Curcumin	13-21	X-linked inhibitor of apoptosis	Homo sapiens	158-162
24138392-11	2014	Curcumin-mediated PTEN up-regulation, DNMT3b down-regulation and PTEN hypomethylation were all attenuated by miR-29b inhibitor.	Curcumin	0-8	phosphatase and tensin homolog	Homo sapiens	18-22
24138392-12	2014	Collectively, it is demonstrated that curcumin can up-regulate miR-29b expression, resulting in DNMT3b down-regulation in HSCs and epigenetically-regulated PTEN involved in the suppression of activated HSCs.	Curcumin	38-46	DNA methyltransferase 3 beta	Homo sapiens	96-102
24138392-12	2014	Collectively, it is demonstrated that curcumin can up-regulate miR-29b expression, resulting in DNMT3b down-regulation in HSCs and epigenetically-regulated PTEN involved in the suppression of activated HSCs.	Curcumin	38-46	phosphatase and tensin homolog	Homo sapiens	156-160
23959480-5	2014	In addition, Western blotting detection suggested that curcumin of high concentrations can induce the release of Cyto-C and the activation of Caspase-3, and that ROS scavenger NAC apparently inhibits apoptosis protein release and activation, consequently slowing the curcumin-induced apoptosis.	Curcumin	55-63	synuclein alpha	Homo sapiens	176-179
26350251-4	2015	Here, we demonstrate that curcumin inhibits a critical step in HR pathway, Rad51 foci formation, and accumulates gamma-H2AX levels in MDA-MB-231 breast cancer cells.	Curcumin	26-34	RAD51 recombinase	Homo sapiens	75-80
23959480-5	2014	In addition, Western blotting detection suggested that curcumin of high concentrations can induce the release of Cyto-C and the activation of Caspase-3, and that ROS scavenger NAC apparently inhibits apoptosis protein release and activation, consequently slowing the curcumin-induced apoptosis.	Curcumin	267-275	synuclein alpha	Homo sapiens	176-179
26496980-8	2015	Numerous pathways, including p53, c-Jun N-terminal kinases (JNK), Akt and extracellular signal-regulated kinases (ERK)1/2 pathways were markedly altered following treatment of THP-1 cells with curcumin and naringenin.	Curcumin	193-201	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-39
24165291-0	2013	Curcumin suppresses malignant glioma cells growth and induces apoptosis by inhibition of SHH/GLI1 signaling pathway in vitro and vivo.	Curcumin	0-8	sonic hedgehog	Mus musculus	89-92
26515460-9	2015	Using a mouse xenograft model we could show a significant decrease of alpha-fetoprotein after combination therapy of oral micellar curcumin and cisplatin.	Curcumin	131-139	alpha fetoprotein	Mus musculus	70-87
24165291-1	2013	AIMS: To study the role of curcumin on glioma cells via the SHH/GLI1 pathway in vitro and vivo.	Curcumin	27-35	sonic hedgehog	Mus musculus	60-63
26648693-0	2015	Attenuation of myocardial fibrosis with curcumin is mediated by modulating expression of angiotensin II AT1/AT2 receptors and ACE2 in rats.	Curcumin	40-48	angiotensin I converting enzyme 2	Rattus norvegicus	126-130
26648693-2	2015	This study tested the hypothesis that inhibition of myocardial fibrosis by curcumin is associated with modulating expression of angiotensin II (Ang II) receptors and angiotensin-converting enzyme 2 (ACE2).	Curcumin	75-83	angiotensin I converting enzyme 2	Rattus norvegicus	166-197
24259976-6	2013	RESULTS: Both pre- and post-treatment with curcumin resulted in a significant decrease in serum ALT compared with APAP treatment group (10 mg/kg: 801.46 +- 661.34 U/L; 20 mg/kg: 99.68 +- 86.48 U/L vs 5406.80 +- 1785.75 U/L, P &lt; 0.001, respectively).	Curcumin	43-51	glutamic pyruvic transaminase, soluble	Mus musculus	96-99
26648693-2	2015	This study tested the hypothesis that inhibition of myocardial fibrosis by curcumin is associated with modulating expression of angiotensin II (Ang II) receptors and angiotensin-converting enzyme 2 (ACE2).	Curcumin	75-83	angiotensin I converting enzyme 2	Rattus norvegicus	199-203
26648693-9	2015	Furthermore, curcumin increased protein level of ACE2 and enhanced its expression in the intermyocardium relative to the Ang II group.	Curcumin	13-21	angiotensin I converting enzyme 2	Rattus norvegicus	49-53
26094731-3	2015	Curcumin and calphostin C suppressed the activity and phosphorylation of recombinant UGT1A3 expressed in Sf9 cells.	Curcumin	0-8	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	85-91
26386842-5	2015	Examination of the potential splicing factors showed that curcumin specifically increased the protein and transcript levels of SRSF1.	Curcumin	58-66	serine and arginine rich splicing factor 1	Homo sapiens	127-132
26386842-7	2015	Interestingly, the curcumin effects on the SMN2 and SRSF1 transcripts were inhibited by a protein deacetylase inhibitor, trichostatin A.	Curcumin	19-27	serine and arginine rich splicing factor 1	Homo sapiens	52-57
25963235-0	2015	Attenuation of hind-limb suspension-induced bone loss by curcumin is associated with reduced oxidative stress and increased vitamin D receptor expression.	Curcumin	57-65	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	124-142
25963235-1	2015	UNLABELLED: Treatment with curcumin attenuated modeled microgravity-induced bone loss, possibly through abating oxidative stress and activating vitamin D receptor.	Curcumin	27-35	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	144-162
20450049-0	2010	[Anticancer activities of curcumin on human hepatocarcinoma cell line Sk-hep-1].	Curcumin	26-34	DNL-type zinc finger	Homo sapiens	73-78
20450049-1	2010	To study the anticancer activities of curcumin on human hepatocarcinoma cell line Sk-hep-1 and its related molecular mechanism which has not been elucidated.	Curcumin	38-46	DNL-type zinc finger	Homo sapiens	85-90
26517556-5	2015	RESULTS: Curcumin treatment reduced the number of heterolysosomes and shifted their subcellular localization to the periphery, as revealed by electron microscopy, and stimulated the release of lysosomal beta-hexosaminidase and exosome markers flotillin-2 and CD63 into the media.	Curcumin	9-17	flotillin 2	Homo sapiens	243-254
23376509-7	2013	Curcumin significantly reduced malondialdehyde and nitric oxide levels, and enchanced reduced glutathione levels and catalase, superoxide dismutase, and glutathione S-transferase enzymes activities in the livers and kidneys of BDL group.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Rattus norvegicus	153-178
26393568-7	2015	The data suggested that, in turmeric, demethoxycurcumin specifically contributed to GLUT2-mediated fructose uptake inhibition, and curcumin did the same to GLUT5-mediated fructose uptake inhibition, but GLUT2 inhibition was more potent.	Curcumin	47-55	solute carrier family 2 member 2	Homo sapiens	84-89
26393568-10	2015	Quercetin, curcumin and bisdemethoxycurcumin contributed to both GLUT5- and GLUT2-mediated fructose uptake inhibition, but the contribution to GLUT5 inhibition was higher than the contribution to GLUT2 inhibition.	Curcumin	11-19	solute carrier family 2 member 2	Homo sapiens	76-81
22711297-9	2013	Further mechanistic investigations revealed that curcumin treatment alone caused a concentration dependent upregulation of Mcl-1, which can be overcome by combining it with MSeA.	Curcumin	49-57	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	123-128
26321746-7	2015	Bioactive nutrients including curcumin offer great potential in altering DNA methylation status which is catalyzed via DNMT1, DNMT3A and 3B.	Curcumin	30-38	DNA methyltransferase 1	Homo sapiens	119-124
26335572-9	2015	RESULT: Combining with piperine can significantly enhance the effect of curcumin, thus preventing the development of gallbladder stones, lowering the saturation of blood lipids and cholesterol in bile, as well as decreasing the expression of NPC1L1 and SREBP2 in both mRNA and protein levels.	Curcumin	72-80	NPC1 like intracellular cholesterol transporter 1	Mus musculus	242-248
26335572-9	2015	RESULT: Combining with piperine can significantly enhance the effect of curcumin, thus preventing the development of gallbladder stones, lowering the saturation of blood lipids and cholesterol in bile, as well as decreasing the expression of NPC1L1 and SREBP2 in both mRNA and protein levels.	Curcumin	72-80	sterol regulatory element binding factor 2	Mus musculus	253-259
26102194-0	2015	Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells.	Curcumin	0-8	ATP binding cassette subfamily A member 1	Homo sapiens	53-58
26212257-0	2015	Resveratrol and curcumin synergistically induces apoptosis in cigarette smoke condensate transformed breast epithelial cells through a p21(Waf1/Cip1) mediated inhibition of Hh-Gli signaling.	Curcumin	16-24	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	135-138
26212257-0	2015	Resveratrol and curcumin synergistically induces apoptosis in cigarette smoke condensate transformed breast epithelial cells through a p21(Waf1/Cip1) mediated inhibition of Hh-Gli signaling.	Curcumin	16-24	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	139-143
26212257-0	2015	Resveratrol and curcumin synergistically induces apoptosis in cigarette smoke condensate transformed breast epithelial cells through a p21(Waf1/Cip1) mediated inhibition of Hh-Gli signaling.	Curcumin	16-24	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	144-148
26212257-5	2015	Resveratrol+curcumin combination caused apoptosis by increasing Bax/Bcl-xL ratio, Cytochrome C release, cleaved product of PARP and caspase 3 in cells.	Curcumin	12-20	BCL2-associated X protein	Mus musculus	64-67
26212257-5	2015	Resveratrol+curcumin combination caused apoptosis by increasing Bax/Bcl-xL ratio, Cytochrome C release, cleaved product of PARP and caspase 3 in cells.	Curcumin	12-20	poly (ADP-ribose) polymerase family, member 1	Mus musculus	123-127
26212257-5	2015	Resveratrol+curcumin combination caused apoptosis by increasing Bax/Bcl-xL ratio, Cytochrome C release, cleaved product of PARP and caspase 3 in cells.	Curcumin	12-20	caspase 3	Mus musculus	132-141
26212257-11	2015	Thus, our findings revealed resveratrol and curcumin synergistically caused apoptosis in cigarette smoke induced breast cancer cells through p2(Waf/Cip1) mediated inhibition of Hedgehog-Gli cascade.	Curcumin	44-52	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	148-152
26094054-0	2015	The inhibitory mechanism by curcumin on the Zac1-enhanced cyclin D1 expression in human keratinocytes.	Curcumin	28-36	PLAG1 like zinc finger 1	Homo sapiens	44-48
26094054-7	2015	RESULTS: Zac1 enhances the expression of cyclin D1, but curcumin decreases both the expression of Zac1 and cyclin D1.	Curcumin	56-64	PLAG1 like zinc finger 1	Homo sapiens	98-102
26094054-8	2015	Interestingly, Zac1-induced cyclin D1 promoter activity is abolished by curcumin.	Curcumin	72-80	PLAG1 like zinc finger 1	Homo sapiens	15-19
26094054-11	2015	The experimental results implied that curcumin may inhibit the expression of ZAC, consequently down-regulate the cyclin D1 expression and decelerate cell-cycle progression of psoriatic keratinocytes.	Curcumin	38-46	PLAG1 like zinc finger 1	Homo sapiens	77-80
26254223-0	2015	Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway.	Curcumin	0-8	vascular endothelial growth factor A	Mus musculus	93-97
26254223-0	2015	Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway.	Curcumin	0-8	vascular endothelial growth factor A	Mus musculus	132-136
26254223-2	2015	Here, we aim to test whether curcumin affects VEGF-VEGFR2 signaling pathway and attenuates defective hematopoiesis induced by VEGF in tumor model.	Curcumin	29-37	vascular endothelial growth factor A	Mus musculus	46-50
26254223-2	2015	Here, we aim to test whether curcumin affects VEGF-VEGFR2 signaling pathway and attenuates defective hematopoiesis induced by VEGF in tumor model.	Curcumin	29-37	vascular endothelial growth factor A	Mus musculus	51-55
26254223-3	2015	We demonstrated that curcumin inhibited proliferation, migration of HUVEC under VEGF stimulation and caused HUVEC apoptosis, and blocked VEGFR2 activation and its downstream signaling pathways in vitro.	Curcumin	21-29	vascular endothelial growth factor A	Mus musculus	80-84
26254223-4	2015	Furthermore, in VEGF over-expressing tumor model, curcumin significantly inhibited the tumor growth accelerated by VEGF in a dose-dependent manner and improved anemia and extramedullary hematopoiesis in livers and spleens of tumor-bearing mice induced by tumor-derived VEGF.	Curcumin	50-58	vascular endothelial growth factor A	Mus musculus	16-20
26254223-4	2015	Furthermore, in VEGF over-expressing tumor model, curcumin significantly inhibited the tumor growth accelerated by VEGF in a dose-dependent manner and improved anemia and extramedullary hematopoiesis in livers and spleens of tumor-bearing mice induced by tumor-derived VEGF.	Curcumin	50-58	vascular endothelial growth factor A	Mus musculus	115-119
26254223-4	2015	Furthermore, in VEGF over-expressing tumor model, curcumin significantly inhibited the tumor growth accelerated by VEGF in a dose-dependent manner and improved anemia and extramedullary hematopoiesis in livers and spleens of tumor-bearing mice induced by tumor-derived VEGF.	Curcumin	50-58	vascular endothelial growth factor A	Mus musculus	115-119
26254223-6	2015	ELISA revealed that curcumin suppressed VEGF secretion from tumor cells both in vitro and in vivo.	Curcumin	20-28	vascular endothelial growth factor A	Mus musculus	40-44
26254223-7	2015	Survival analysis showed that curcumin significantly improved survival ability of VEGF tumor-bearing mice.	Curcumin	30-38	vascular endothelial growth factor A	Mus musculus	82-86
26254223-8	2015	Taken together, these findings establish curcumin as a modulator of VEGF and VEGF-VEGFR2 signaling pathway, with potential implication for improving the quality of life of cancer patients.	Curcumin	41-49	kinase insert domain receptor	Homo sapiens	82-88
26119880-0	2015	Curcumin attenuates brain edema in mice with intracerebral hemorrhage through inhibition of AQP4 and AQP9 expression.	Curcumin	0-8	aquaporin 4	Mus musculus	92-96
26119880-9	2015	Furthermore, curcumin dose-dependently decreased the gene and protein expression of AQP4 and AQP9, but not AQP1 post ICH.	Curcumin	13-21	aquaporin 4	Mus musculus	84-88
26119880-11	2015	CONCLUSION: Curcumin effectively attenuates brain edema in mice with ICH through inhibition of the NF-kappaB pathway and subsequently the expression of AQP4 and AQP9.	Curcumin	12-20	aquaporin 4	Mus musculus	152-156
25934542-4	2015	We have found that several PTC+ transcripts including that of serine/arginine-rich splicing factor 1 (SRSF1) were specifically increased in cells by curcumin.	Curcumin	149-157	serine and arginine rich splicing factor 1	Homo sapiens	62-100
25934542-4	2015	We have found that several PTC+ transcripts including that of serine/arginine-rich splicing factor 1 (SRSF1) were specifically increased in cells by curcumin.	Curcumin	149-157	serine and arginine rich splicing factor 1	Homo sapiens	102-107
25882494-5	2015	Curcumin, SAHA and trichostatin A showed to down-regulate the PHOX2B promoter activity which resulted in a decrease of both protein and mRNA expressions.	Curcumin	0-8	paired like homeobox 2B	Homo sapiens	62-68
25882494-6	2015	In addition, we have observed that curcumin acts by interfering with PBX-1/MEIS-1, NF-kappaB and AP-1 complexes, in this work demonstrated for the first time to regulate the transcription of the PHOX2B gene.	Curcumin	35-43	Meis homeobox 1	Homo sapiens	75-81
25882494-6	2015	In addition, we have observed that curcumin acts by interfering with PBX-1/MEIS-1, NF-kappaB and AP-1 complexes, in this work demonstrated for the first time to regulate the transcription of the PHOX2B gene.	Curcumin	35-43	paired like homeobox 2B	Homo sapiens	195-201
26305715-7	2015	Moreover, curcumin alleviated the symptom of hyperlipidemia and hepatic steatosis via modulating the expression of sterol regulatory element-binding protein-1c, fatty acid synthase, and peroxisome proliferator-activated receptor-alpha as well as the activity of carnitine palmitoyltransferase 1.	Curcumin	10-18	fatty acid synthase	Homo sapiens	161-180
25944087-2	2015	METHODS AND RESULTS: The expression of classic M2 markers, including macrophage mannose receptor (MMR), arginase-1 (Arg-1) and peroxisome proliferator-activated receptor-gamma (PPAR-gamma) was upregulated in curcumin-treated Raw264.7 macrophages.	Curcumin	208-216	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	127-175
25944087-4	2015	Curcumin notably increased STAT6 phosphorylation.	Curcumin	0-8	signal transducer and activator of transcription 6	Rattus norvegicus	27-32
25944087-6	2015	In vivo, 6-week old male Lewis rats were used to induce EAM and orally administrated with curcumin or corn oil for 3weeks after myosin injection.	Curcumin	90-98	myosin-6-like	Zea mays	128-134
25923908-0	2015	Insights into the binding mode of curcumin to MD-2: studies from molecular docking, molecular dynamics simulations and experimental assessments.	Curcumin	34-42	lymphocyte antigen 96	Homo sapiens	46-50
25923908-2	2015	Recently, several reports mentioned that myeloid differentiation protein 2 (MD-2) may be the direct target of curcumin in the inhibition of lipopolysaccharide (LPS) signaling.	Curcumin	110-118	lymphocyte antigen 96	Homo sapiens	41-74
25923908-2	2015	Recently, several reports mentioned that myeloid differentiation protein 2 (MD-2) may be the direct target of curcumin in the inhibition of lipopolysaccharide (LPS) signaling.	Curcumin	110-118	lymphocyte antigen 96	Homo sapiens	76-80
25923908-3	2015	However, the exact interaction between curcumin and MD-2 is still incompletely understood.	Curcumin	39-47	lymphocyte antigen 96	Homo sapiens	52-56
25923908-4	2015	In the present study, computational and experimental methods were employed to explore the underlying structural mechanism of curcumin binding to the MD-2 protein.	Curcumin	125-133	lymphocyte antigen 96	Homo sapiens	149-153
25923908-5	2015	Molecular docking and molecular dynamics (MD) simulation studies showed that curcumin could be embedded into the hydrophobic pocket of MD-2 and form stable hydrogen bonding interactions with residues R90 and Y102 of MD-2.	Curcumin	77-85	lymphocyte antigen 96	Homo sapiens	135-139
25923908-5	2015	Molecular docking and molecular dynamics (MD) simulation studies showed that curcumin could be embedded into the hydrophobic pocket of MD-2 and form stable hydrogen bonding interactions with residues R90 and Y102 of MD-2.	Curcumin	77-85	lymphocyte antigen 96	Homo sapiens	216-220
25923908-6	2015	Moreover, experimental results of curcumin binding to the MD-2(R90A/Y102A) mutant further confirmed that residues ARG-90 and TYR-102 contribute to the recognition process of curcumin binding to the MD-2 protein.	Curcumin	34-42	lymphocyte antigen 96	Homo sapiens	58-62
25923908-6	2015	Moreover, experimental results of curcumin binding to the MD-2(R90A/Y102A) mutant further confirmed that residues ARG-90 and TYR-102 contribute to the recognition process of curcumin binding to the MD-2 protein.	Curcumin	34-42	lymphocyte antigen 96	Homo sapiens	198-202
25923908-6	2015	Moreover, experimental results of curcumin binding to the MD-2(R90A/Y102A) mutant further confirmed that residues ARG-90 and TYR-102 contribute to the recognition process of curcumin binding to the MD-2 protein.	Curcumin	174-182	lymphocyte antigen 96	Homo sapiens	58-62
25923908-6	2015	Moreover, experimental results of curcumin binding to the MD-2(R90A/Y102A) mutant further confirmed that residues ARG-90 and TYR-102 contribute to the recognition process of curcumin binding to the MD-2 protein.	Curcumin	174-182	lymphocyte antigen 96	Homo sapiens	198-202
25923908-7	2015	In conclusion, we have explored the binding mechanism of curcumin to MD-2; more importantly, this work could offer useful references for designing novel analogs of curcumin as potential anti-inflammatory agents targeting the MD-2 protein.	Curcumin	57-65	lymphocyte antigen 96	Homo sapiens	69-73
25923908-7	2015	In conclusion, we have explored the binding mechanism of curcumin to MD-2; more importantly, this work could offer useful references for designing novel analogs of curcumin as potential anti-inflammatory agents targeting the MD-2 protein.	Curcumin	57-65	lymphocyte antigen 96	Homo sapiens	225-229
25923908-7	2015	In conclusion, we have explored the binding mechanism of curcumin to MD-2; more importantly, this work could offer useful references for designing novel analogs of curcumin as potential anti-inflammatory agents targeting the MD-2 protein.	Curcumin	164-172	lymphocyte antigen 96	Homo sapiens	69-73
25923908-7	2015	In conclusion, we have explored the binding mechanism of curcumin to MD-2; more importantly, this work could offer useful references for designing novel analogs of curcumin as potential anti-inflammatory agents targeting the MD-2 protein.	Curcumin	164-172	lymphocyte antigen 96	Homo sapiens	225-229
26261481-10	2015	Meanwhile, down-regulation of MMP-9 gene expression quantity and NF-kappaB activity could promote the anti-cancer effect of curcumin on cell viability of GCT cells.	Curcumin	124-132	matrix metallopeptidase 9	Homo sapiens	30-35
26261481-12	2015	Taken together, our results suggest that curcumin inhibits cell proliferation and promotes apoptosis in osteoclastoma cell through suppression of MMP-9 and NF-kappaB, and activation JNK signaling pathways.	Curcumin	41-49	matrix metallopeptidase 9	Homo sapiens	146-151
25985292-6	2015	Employing biochemical, biophysical and cell based assays we discovered that curcumin pyrazole (3) and its derivative N-(3-Nitrophenylpyrazole) curcumin (15) exhibit remarkable potency in not only arresting fibrillization and disrupting preformed fibrils but also preventing formation of A11 conformation in the protein that imparts toxic effects.	Curcumin	76-84	immunoglobulin kappa variable 3D-20	Homo sapiens	287-290
25712055-0	2015	Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer.	Curcumin	19-27	microRNA 27a	Mus musculus	105-112
25761397-10	2015	After treatment with curcumin, the levels of sera MDA were significantly reduced, the TAC, TP53, and Ass (1-40) levels were significantly increased (P &lt; 0.05).	Curcumin	21-29	tumor protein p53	Rattus norvegicus	91-95
25542235-0	2015	Curcumin reverses cisplatin resistance in cisplatin-resistant lung caner cells by inhibiting FA/BRCA pathway.	Curcumin	0-8	BRCA1 DNA repair associated	Homo sapiens	96-100
25542235-8	2015	Moreover, we observed that FA/BRCA pathway DNA damage repair processes, such as DDP-induced FANCD2 monoubiquitination and nuclear foci formation were downregulated in the presence of curcumin, suggesting that curcumin enhanced sensitivity to DDP in A549/DDP cells through the inhibition of FA/BRCA pathway.	Curcumin	183-191	BRCA1 DNA repair associated	Homo sapiens	30-34
25542235-8	2015	Moreover, we observed that FA/BRCA pathway DNA damage repair processes, such as DDP-induced FANCD2 monoubiquitination and nuclear foci formation were downregulated in the presence of curcumin, suggesting that curcumin enhanced sensitivity to DDP in A549/DDP cells through the inhibition of FA/BRCA pathway.	Curcumin	183-191	FA complementation group D2	Homo sapiens	92-98
25542235-8	2015	Moreover, we observed that FA/BRCA pathway DNA damage repair processes, such as DDP-induced FANCD2 monoubiquitination and nuclear foci formation were downregulated in the presence of curcumin, suggesting that curcumin enhanced sensitivity to DDP in A549/DDP cells through the inhibition of FA/BRCA pathway.	Curcumin	183-191	BRCA1 DNA repair associated	Homo sapiens	293-297
25542235-8	2015	Moreover, we observed that FA/BRCA pathway DNA damage repair processes, such as DDP-induced FANCD2 monoubiquitination and nuclear foci formation were downregulated in the presence of curcumin, suggesting that curcumin enhanced sensitivity to DDP in A549/DDP cells through the inhibition of FA/BRCA pathway.	Curcumin	209-217	BRCA1 DNA repair associated	Homo sapiens	30-34
25542235-8	2015	Moreover, we observed that FA/BRCA pathway DNA damage repair processes, such as DDP-induced FANCD2 monoubiquitination and nuclear foci formation were downregulated in the presence of curcumin, suggesting that curcumin enhanced sensitivity to DDP in A549/DDP cells through the inhibition of FA/BRCA pathway.	Curcumin	209-217	FA complementation group D2	Homo sapiens	92-98
25542235-8	2015	Moreover, we observed that FA/BRCA pathway DNA damage repair processes, such as DDP-induced FANCD2 monoubiquitination and nuclear foci formation were downregulated in the presence of curcumin, suggesting that curcumin enhanced sensitivity to DDP in A549/DDP cells through the inhibition of FA/BRCA pathway.	Curcumin	209-217	BRCA1 DNA repair associated	Homo sapiens	293-297
25542235-10	2015	In conclusion, by suppressing the FA/BRCA pathway DNA repair, curcumin potentiates DDP-induced proliferation inhibitory effect and apoptosis in A549/DDP cell, indicating that curcumin may serve as a chemosensitizer to cross-link-inducing anticancer drugs DDP.	Curcumin	175-183	BRCA1 DNA repair associated	Homo sapiens	37-41
24793792-6	2015	Curcumin, an AP-1 inhibitor, was also found to regulate PGRN promoter activity and expression including its downstream effectors aforementioned.	Curcumin	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-17
24793792-11	2015	Our data suggest that a new strategy combining current regimens with compounds targeting PGRN/AP-1 loop like curcumin may significantly improve the therapeutic outcome of GBM.	Curcumin	109-117	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	94-98
25960232-5	2015	Forced overexpression of Bcl-2 also blocked curcumin-induced autophagy in MCF-7 cells, through its inhibitory interactions with Beclin-1.	Curcumin	44-52	beclin 1	Homo sapiens	128-136
25676631-6	2015	SULT1A3 is a major isoform catalyzing sulfonation of curcumin and demethoxycurcumin, but not for bisdemethoxycurcumin.	Curcumin	53-61	sulfotransferase family 1A member 3	Homo sapiens	0-7
25789029-7	2015	In the MM RPMI 8226 cells treated with curcumin, the expression of the p53 and Bax genes was upregulated, while the expression of the MDM2 gene was downregulated.	Curcumin	39-47	MDM2 proto-oncogene	Homo sapiens	134-138
25644192-0	2015	Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells.	Curcumin	0-8	sirtuin 7	Homo sapiens	67-72
25644192-7	2015	Curcumin caused inhibition of rDNA transcription, which could be due to SIRT7 downregulation, site-specific methylation of RNA18S5 gene promoter or both.	Curcumin	0-8	sirtuin 7	Homo sapiens	72-77
25644192-7	2015	Curcumin caused inhibition of rDNA transcription, which could be due to SIRT7 downregulation, site-specific methylation of RNA18S5 gene promoter or both.	Curcumin	0-8	RNA, 18S ribosomal N5	Homo sapiens	123-130
25594614-9	2015	Conversely, the curcumin increased the levels of the NAMPT and SIRT proteins in the cisplatin-treated rats (p&lt;0.05).	Curcumin	16-24	nicotinamide phosphoribosyltransferase	Rattus norvegicus	53-58
25574201-12	2015	The serum level of E-selectin and the expression levels of TSP-1 and TGF-beta1 significantly increased in the sepsis rats when compared with the control group rats; however, the levels decreased significantly following treatment with curcumin (10 or 20 mg/kg).	Curcumin	234-242	selectin E	Rattus norvegicus	19-29
20450049-2	2010	In the present study,we showed that curcumin inhibited proliferation of Sk-hep-1 cells in a dose-dependent manner through MTF assay.	Curcumin	36-44	DNL-type zinc finger	Homo sapiens	75-80
20450049-3	2010	The effect of curcumin on apoptosis in Sk-hep-1 cells was investigated by DAPI staining and the various apoptosis was observed in hepatocarcinoma cell lines Sk-hep-1, HepG2 and Hep3B, but not in normal liver cell line Chang"s liver with curcumin treatment.	Curcumin	14-22	DNL-type zinc finger	Homo sapiens	42-47
20450049-4	2010	Cell cycle analysis results showed that curcumin treatment resulted in dramatic accumulation of Sk-hep-1 cells at the G0/G1 or G2/M phase.	Curcumin	40-48	DNL-type zinc finger	Homo sapiens	99-104
20450049-5	2010	The effect of curcumin on the expression of anti-apoptosis genes (Survivin and BCl-xL) and drug resistance genes (DRG2 and MDR1) was studied by reverse transcription-polymerase chain reaction (RT-PCR).	Curcumin	14-22	developmentally regulated GTP binding protein 2	Homo sapiens	114-118
20450049-7	2010	These results indicate that curcumin is able to inhibit proliferation and induce apoptosis in Sk-hep-1 cells and it may cause by down-regulating the expression of MDR1 mRNA.	Curcumin	28-36	DNL-type zinc finger	Homo sapiens	97-102
21364631-5	2010	The pivotal role of the JNK/c-Jun/AP-1 pathway for gal-1-induced apoptosis was documented by reduction of DNA fragmentation after inhibition JNK by SP600125 (20 muM) or inhibition of AP-1 activation by curcumin (2 muM).	Curcumin	202-210	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-33
19800021-6	2010	The IL-1-mediated induction of C/EBPdelta expression was attenuated in the presence of pharmacological inhibitors against c-Jun N-terminal kinase (JNK) (curcumin and SP600125), casein kinase 2 (CK2) (apigenin) and nuclear factor-kappaB (NF-kappaB) (NF-kappaB activation inhibitor).	Curcumin	153-161	CCAAT enhancer binding protein delta	Homo sapiens	31-41
19901911-14	2010	Curcumin decreased the intrahepatic gene expression of monocyte chemoattractant protein-1, CD11b, procollagen type I and tissue inhibitor of metalloprotease (TIMP)-1, together with protein levels of alpha-smooth muscle-actin, a marker of fibrogenic cells.	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	55-89
20160430-4	2010	Fluorescence-activated cell-sorting (FACS) analysis demonstrated curcumin-induced cell cycle arrest at G(2)/M accompanied by inhibition of cyclin D(1) protein expression.	Curcumin	65-73	cyclin D1	Mus musculus	139-150
20160430-5	2010	Curcumin had a small effect on necrosis of TtT/GF cells, but it mainly stimulated apoptosis as demonstrated by FACS analysis (Annexin V-fluorescein isothiocyannate/7-aminoactinomycin D staining).	Curcumin	0-8	annexin A5	Mus musculus	126-135
20160430-7	2010	Functional studies on FS cell-derived compounds showed that curcumin inhibited mRNA synthesis and release of angiogenic vascular endothelial growth factor-A (VEGF-A).	Curcumin	60-68	vascular endothelial growth factor A	Mus musculus	120-156
20160430-7	2010	Functional studies on FS cell-derived compounds showed that curcumin inhibited mRNA synthesis and release of angiogenic vascular endothelial growth factor-A (VEGF-A).	Curcumin	60-68	vascular endothelial growth factor A	Mus musculus	158-164
19937698-0	2009	Reduced expression of ATP7B affected by Wilson disease-causing mutations is rescued by pharmacological folding chaperones 4-phenylbutyrate and curcumin.	Curcumin	143-151	ATPase copper transporting beta	Homo sapiens	22-27
19937698-10	2009	Treatment with pharmacological chaperones 4-phenylbutyrate (4-PBA) and curcumin, a clinically approved compound, partially restored protein expression of most ATP7B mutants.	Curcumin	71-79	ATPase copper transporting beta	Homo sapiens	159-164
19854518-9	2009	A chimeric high affinity and specific recombinant antibody against hCGbeta linked to curcumin kills hCGbeta expressing T lymphoblastic leukemia cells without any deleterious effect.	Curcumin	85-93	chorionic gonadotropin subunit beta 3	Homo sapiens	67-74
19854518-9	2009	A chimeric high affinity and specific recombinant antibody against hCGbeta linked to curcumin kills hCGbeta expressing T lymphoblastic leukemia cells without any deleterious effect.	Curcumin	85-93	chorionic gonadotropin subunit beta 3	Homo sapiens	100-107
19804785-7	2009	Curcumin and insulin inhibited diabetes-induced elevation in the gene expression of acetylcholine esterase, Glut3, insulin and cholinergic receptors in the cerebellum of diabetic rats.	Curcumin	0-8	solute carrier family 2 member 3	Rattus norvegicus	108-113
19804785-8	2009	SIGNIFICANCE: Our studies suggest that curcumin plays a vital role in regulating the activity of cholinergic and insulin receptors and mechanism of glucose transportation through Glut3, which results in normalizing the diabetes-mediated cerebellar disorders.	Curcumin	39-47	solute carrier family 2 member 3	Rattus norvegicus	179-184
19699734-9	2009	These results suggested that curcumin suppressed the increased bone resorptive activity through the prevention of osteoclastogenesis associated with inhibition of the expression of c-fos and c-jun in the diabetic rats.	Curcumin	29-37	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	181-186
19723881-5	2009	Despite its proapoptotic effects, curcumin pretreatment of human melanoma cell lines inhibited the phosphorylation of STAT1 protein and downstream gene transcription following IFN-alpha and IFN-gamma as determined by immunoblot analysis and real time PCR, respectively.	Curcumin	34-42	signal transducer and activator of transcription 1	Homo sapiens	118-123
19723881-6	2009	Pretreatment of peripheral blood mononuclear cells from healthy donors with curcumin also inhibited the ability of IFN-alpha, IFN-gamma, and interleukin-2 to phosphorylate STAT proteins critical for their antitumor activity (STAT1 and STAT5, respectively) and their respective downstream gene expression as measured by real time PCR.	Curcumin	76-84	signal transducer and activator of transcription 1	Homo sapiens	172-176
19723881-6	2009	Pretreatment of peripheral blood mononuclear cells from healthy donors with curcumin also inhibited the ability of IFN-alpha, IFN-gamma, and interleukin-2 to phosphorylate STAT proteins critical for their antitumor activity (STAT1 and STAT5, respectively) and their respective downstream gene expression as measured by real time PCR.	Curcumin	76-84	signal transducer and activator of transcription 1	Homo sapiens	225-230
19445907-0	2009	Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	48-52
19445907-12	2009	Curcumin high dose (100 mg/kg) upregulated Nrf2 and HO-1 in MCAO-affected brain tissue and reduced infarct volume (P&lt;0.05), brain water content (P&lt;0.05) and behavioral deficits (P&lt;0.05) caused by MCAO.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	52-56
19393301-7	2009	The curcumin diet counteracted the effects of FPI and elevated the levels of AMPK, uMtCK, COX-II in Cur/FPI rats as compared to RD/sham rats.	Curcumin	4-12	creatine kinase, mitochondrial 1	Rattus norvegicus	83-88
19605645-8	2009	Treatment of the 3xTg-AD mice on high-fat diet with fish oil or curcumin or a combination of both for 4 months reduced phosphorylated JNK, IRS-1, and tau and prevented the degradation of total IRS-1.	Curcumin	64-72	mitogen-activated protein kinase 8	Mus musculus	134-137
19594013-0	2009	[Inhibitory effect of curcumin on MMP-2 and MMP-9 expression induced by polyethylene wear particles and its mechanism].	Curcumin	22-30	matrix metallopeptidase 2	Mus musculus	34-39
19445025-11	2009	Degradation of accumulated beta-catenin with curcumin is one of the major mechanisms of chemoprevention in colorectal carcinogenesis.	Curcumin	45-53	catenin (cadherin associated protein), beta 1	Mus musculus	27-39
19321585-0	2009	Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice.	Curcumin	8-16	CD4 antigen	Mus musculus	38-41
22009832-8	2009	This curcumin-induced apoptosis in U2OS cells was accompanied by up-regulation of Bax, Bak, and p-Bad and down-regulation of Bcl-2, but no effect on the levels of Bcl-X(L) or Bad proteins was noted.	Curcumin	5-13	BCL2 antagonist/killer 1	Homo sapiens	87-90
19189206-0	2009	Interaction of curcumin and diacetylcurcumin with the lipocalin member beta-lactoglobulin.	Curcumin	15-23	beta-lactoglobulin	Bos taurus	71-89
19189206-1	2009	The binding of curcumin (CUR) and diacetylcurcumin (DAC) to bovine beta-lactoglobulin (BLG) genetic variant B was investigated by fluorescence and circular dichroism techniques.	Curcumin	15-23	beta-lactoglobulin	Bos taurus	67-85
19189206-1	2009	The binding of curcumin (CUR) and diacetylcurcumin (DAC) to bovine beta-lactoglobulin (BLG) genetic variant B was investigated by fluorescence and circular dichroism techniques.	Curcumin	15-23	beta-lactoglobulin	Bos taurus	87-90
18410527-6	2009	NAC-mediated inhibition of 25-microM curcumin-induced apoptosis was demonstrated to act in part via restored HO-1-induction, since the rescuing effect of NAC could be reduced by inhibiting HO-activity.	Curcumin	37-45	X-linked Kx blood group	Homo sapiens	0-3
18410527-6	2009	NAC-mediated inhibition of 25-microM curcumin-induced apoptosis was demonstrated to act in part via restored HO-1-induction, since the rescuing effect of NAC could be reduced by inhibiting HO-activity.	Curcumin	37-45	X-linked Kx blood group	Homo sapiens	154-157
18410527-8	2009	On a functional level, fibroblast-mediated collagen gel contraction, an in vitro wound contraction model, was completely prevented by 25-microM curcumin, while this could be reversed by co-incubation with NAC, an effect that was also partially HO-mediated.	Curcumin	144-152	X-linked Kx blood group	Homo sapiens	205-208
19372569-4	2009	Curcumin also potentiated the apoptotic effects of thalidomide and bortezomib by down-regulating the constitutive activation of NF-kappaB and Akt, and this correlated with the suppression of NF-kappaB-regulated gene products, including cyclin D1, Bcl-xL, Bcl-2, TRAF1, cIAP-1, XIAP, survivin, and vascular endothelial growth factor.	Curcumin	0-8	X-linked inhibitor of apoptosis	Homo sapiens	277-281
19112019-1	2009	Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect.	Curcumin	40-48	DNA methyltransferase 1	Homo sapiens	136-141
19112019-1	2009	Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect.	Curcumin	74-82	DNA methyltransferase 1	Homo sapiens	53-58
19112019-1	2009	Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect.	Curcumin	74-82	DNA methyltransferase 1	Homo sapiens	136-141
18495463-6	2009	Zymography analysis exhibited that curcumin, DMC and BDMC significantly decreased uPA, active-MMP-2 and MMP-9 but not pro-MMP-2 secretion from the cells in a dose-dependent manner, in which BDMC and DMC show higher potency than curcumin.	Curcumin	35-43	matrix metallopeptidase 9	Homo sapiens	104-109
19889203-8	2009	RESULTS: Treatment with curcumin and resveratrol suppressed NF-kappaB-regulated gene products involved in inflammation (cyclooxygenase-2, matrix metalloproteinase (MMP)-3, MMP-9, vascular endothelial growth factor), inhibited apoptosis (Bcl-2, Bcl-xL, and TNF-alpha receptor-associated factor 1) and prevented activation of caspase-3.	Curcumin	24-32	matrix metallopeptidase 9	Homo sapiens	172-177
18762247-3	2008	We show for the first time that curcumin-induced rapid ROS generation causes the release of apoptosis inducing factor (AIF) from the mitochondria to the cytosol and nucleus, hence, leading to caspase 3-independent apoptosis.	Curcumin	32-40	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	92-117
18762247-3	2008	We show for the first time that curcumin-induced rapid ROS generation causes the release of apoptosis inducing factor (AIF) from the mitochondria to the cytosol and nucleus, hence, leading to caspase 3-independent apoptosis.	Curcumin	32-40	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	119-122
18762247-3	2008	We show for the first time that curcumin-induced rapid ROS generation causes the release of apoptosis inducing factor (AIF) from the mitochondria to the cytosol and nucleus, hence, leading to caspase 3-independent apoptosis.	Curcumin	32-40	caspase 3	Mus musculus	192-201
18762247-4	2008	However, our studies also show that curcumin induces the release of cytochrome c from mitochondria, causing activation of caspase 3, and concomitant PARP cleavage, which is the hallmark of caspase-dependent apoptosis.	Curcumin	36-44	caspase 3	Mus musculus	122-131
18762247-4	2008	However, our studies also show that curcumin induces the release of cytochrome c from mitochondria, causing activation of caspase 3, and concomitant PARP cleavage, which is the hallmark of caspase-dependent apoptosis.	Curcumin	36-44	poly (ADP-ribose) polymerase family, member 1	Mus musculus	149-153
18762247-5	2008	Furthermore, curcumin-induced ROS generation leads to the induction of the proapoptotic protein p53 and its effector protein p21 and down-regulation of cell cycle regulatory proteins such as Rb and cyclin D1 and D3.	Curcumin	13-21	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	125-128
18762247-5	2008	Furthermore, curcumin-induced ROS generation leads to the induction of the proapoptotic protein p53 and its effector protein p21 and down-regulation of cell cycle regulatory proteins such as Rb and cyclin D1 and D3.	Curcumin	13-21	cyclin D1	Mus musculus	198-207
18762247-6	2008	Both glutathione (GSH) and N-acetylcysteine (NAC) pretreatment resulted in the complete inhibition of curcumin-induced ROS generation, AIF release from mitochondria, and caspase activation.	Curcumin	102-110	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	135-138
18762247-8	2008	In conclusion, our data show that in addition to caspase 3 activation, curcumin-induced rapid ROS generation leads to AIF release, and the activation of the caspase-independent apoptotic pathway.	Curcumin	71-79	caspase 3	Mus musculus	49-58
18762247-8	2008	In conclusion, our data show that in addition to caspase 3 activation, curcumin-induced rapid ROS generation leads to AIF release, and the activation of the caspase-independent apoptotic pathway.	Curcumin	71-79	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	118-121
18818316-2	2008	Although it has been demonstrated effective in reducing relapse rate in ulcerative colitis patients, curcumin"s effectiveness in Crohn"s disease (CD) or in Th-1/Th-17 mediated immune models of CD has not been evaluated.	Curcumin	101-109	negative elongation factor complex member C/D	Homo sapiens	156-160
18818316-9	2008	In conclusion, curcumin demonstrates limited effectiveness on Th-1 mediated colitis in IL-10(-/-) mice, with moderately improved colonic morphology, but with no significant effect on pathogenic T cell responses and in situ NF-kappaB activity.	Curcumin	15-23	negative elongation factor complex member C/D	Homo sapiens	62-66
25224922-0	2015	Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures.	Curcumin	29-37	transthyretin	Homo sapiens	0-13
25224922-5	2015	This strategy is applied to the crystallization of TTR complexes with curcumin and 16alpha-bromo-estradiol.	Curcumin	70-78	transthyretin	Homo sapiens	51-54
26214199-5	2015	Curcumin was incorporated into the self-assembled onion-type micelle by physical encapsulation into the PCL core with an entrapment capacity of 6 wt%.	Curcumin	0-8	PHD finger protein 1	Homo sapiens	104-107
26090395-0	2015	Oral Curcumin (Meriva) Is Effective as an Adjuvant Treatment and Is Able to Reduce IL-22 Serum Levels in Patients with Psoriasis Vulgaris.	Curcumin	5-13	interleukin 22	Homo sapiens	83-88
26090395-6	2015	Moreover, IL-22 serum levels were significantly reduced in patients treated with oral curcumin.	Curcumin	86-94	interleukin 22	Homo sapiens	10-15
23846485-6	2013	Curcumin-induced production of reactive oxygen species did not affect total expression of DR5 but it enhanced mobilization of DR5 to the plasma membrane.	Curcumin	0-8	TNF receptor superfamily member 10b	Homo sapiens	126-129
26090395-7	2015	In conclusion, curcumin was demonstrated to be effective as an adjuvant therapy for the treatment of psoriasis vulgaris and to significantly reduce serum levels of IL-22.	Curcumin	15-23	interleukin 22	Homo sapiens	164-169
25998190-9	2015	RESULTS: Curcumin dose-dependently inhibited M1 macrophage polarization and the production of TNF-alpha, IL-6, and IL-12B (p40).	Curcumin	9-17	interleukin 12B	Homo sapiens	115-121
18703151-11	2008	Interestingly, curcumin prevented the decrease in DK4 expression, but not in cyclin D1.	Curcumin	15-23	immunoglobulin heavy diversity 5-5	Homo sapiens	50-53
24065177-5	2013	Osteopontin (OPN) mRNA and protein expression were significantly reduced in curcumin and BPS-treated SKOV3 cells and curcumin-treated DCs.	Curcumin	76-84	secreted phosphoprotein 1	Homo sapiens	0-11
18829502-1	2008	PURPOSE: The purpose of this study was to determine whether a liposomal formulation of curcumin would suppress the growth of head and neck squamous cell carcinoma (HNSCC) cell lines CAL27 and UM-SCC1 in vitro and in vivo.	Curcumin	87-95	RAD21 cohesin complex component	Mus musculus	195-199
26539236-0	2015	The Protective Effects of Curcumin on Obesity-Related Glomerulopathy Are Associated with Inhibition of Wnt/beta-Catenin Signaling Activation in Podocytes.	Curcumin	26-34	catenin (cadherin associated protein), beta 1	Mus musculus	107-119
26539236-2	2015	Cellular experiments in vitro showed that curcumin significantly antagonized leptin-induced downregulation of the mRNA and protein expression of podocyte-associated molecules including nephrin, podocin, podoplanin, and podocalyxin.	Curcumin	42-50	nephrosis 1, nephrin	Mus musculus	185-192
26539236-2	2015	Cellular experiments in vitro showed that curcumin significantly antagonized leptin-induced downregulation of the mRNA and protein expression of podocyte-associated molecules including nephrin, podocin, podoplanin, and podocalyxin.	Curcumin	42-50	nephrosis 2, podocin	Mus musculus	194-201
26539236-2	2015	Cellular experiments in vitro showed that curcumin significantly antagonized leptin-induced downregulation of the mRNA and protein expression of podocyte-associated molecules including nephrin, podocin, podoplanin, and podocalyxin.	Curcumin	42-50	podocalyxin-like	Mus musculus	219-230
26539236-4	2015	Furthermore, the experiments in vitro and in vivo both displayed that curcumin could downregulate the mRNA and protein expressions of Wnt1, Wnt2b, Wnt6, and beta-catenin and upregulate the phosphorylation level of beta-catenin protein in podocytes and renal tissue.	Curcumin	70-78	wingless-type MMTV integration site family, member 6	Mus musculus	147-151
26539236-4	2015	Furthermore, the experiments in vitro and in vivo both displayed that curcumin could downregulate the mRNA and protein expressions of Wnt1, Wnt2b, Wnt6, and beta-catenin and upregulate the phosphorylation level of beta-catenin protein in podocytes and renal tissue.	Curcumin	70-78	catenin (cadherin associated protein), beta 1	Mus musculus	157-169
26539236-4	2015	Furthermore, the experiments in vitro and in vivo both displayed that curcumin could downregulate the mRNA and protein expressions of Wnt1, Wnt2b, Wnt6, and beta-catenin and upregulate the phosphorylation level of beta-catenin protein in podocytes and renal tissue.	Curcumin	70-78	catenin (cadherin associated protein), beta 1	Mus musculus	214-226
18844852-4	2008	We report novel dietary ligands for VDR including curcumin, gamma-tocotrienol, and essential fatty acid derivatives that likely play a role in the bioactions of VDR.	Curcumin	50-58	vitamin D receptor	Homo sapiens	36-39
18844852-4	2008	We report novel dietary ligands for VDR including curcumin, gamma-tocotrienol, and essential fatty acid derivatives that likely play a role in the bioactions of VDR.	Curcumin	50-58	vitamin D receptor	Homo sapiens	161-164
18794131-7	2008	Knockdown of JunD expression could partially reduce the curcumin-induced HLJ1 activation and diminish the anti-invasive effect of curcumin, indicating that JunD would seem to be involved in curcumin-induced HLJ1 expression.	Curcumin	130-138	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	73-77
18794131-7	2008	Knockdown of JunD expression could partially reduce the curcumin-induced HLJ1 activation and diminish the anti-invasive effect of curcumin, indicating that JunD would seem to be involved in curcumin-induced HLJ1 expression.	Curcumin	130-138	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	207-211
18794131-7	2008	Knockdown of JunD expression could partially reduce the curcumin-induced HLJ1 activation and diminish the anti-invasive effect of curcumin, indicating that JunD would seem to be involved in curcumin-induced HLJ1 expression.	Curcumin	130-138	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	73-77
18794131-7	2008	Knockdown of JunD expression could partially reduce the curcumin-induced HLJ1 activation and diminish the anti-invasive effect of curcumin, indicating that JunD would seem to be involved in curcumin-induced HLJ1 expression.	Curcumin	130-138	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	207-211
18794131-8	2008	Curcumin was able to induce c-Jun NH(2)-kinase (JNK) phosphorylation, whereas the JNK inhibitor (SP-600125) could attenuate curcumin-induced JunD and HLJ1 expression.	Curcumin	124-132	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	150-154
18794131-9	2008	Activation of HLJ1 by curcumin further leads to up-regulation of E-cadherin and a suppression of cancer cell invasion.	Curcumin	22-30	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	14-18
24065177-5	2013	Osteopontin (OPN) mRNA and protein expression were significantly reduced in curcumin and BPS-treated SKOV3 cells and curcumin-treated DCs.	Curcumin	76-84	secreted phosphoprotein 1	Homo sapiens	13-16
18794131-10	2008	Our results show that curcumin induces HLJ1, through activation of the JNK/JunD pathway, and inhibits lung cancer cell invasion and metastasis by modulating E-cadherin expression.	Curcumin	22-30	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	39-43
24065177-5	2013	Osteopontin (OPN) mRNA and protein expression were significantly reduced in curcumin and BPS-treated SKOV3 cells and curcumin-treated DCs.	Curcumin	117-125	secreted phosphoprotein 1	Homo sapiens	0-11
18628248-3	2008	A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin).	Curcumin	405-413	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	181-185
26845849-8	2015	Adding of curcumin to the cardiomyocyte cell culture contributed to increasing of the Mn-SOD activity by 14%, catalase--by 23%.	Curcumin	10-18	superoxide dismutase 2	Rattus norvegicus	86-92
24065177-5	2013	Osteopontin (OPN) mRNA and protein expression were significantly reduced in curcumin and BPS-treated SKOV3 cells and curcumin-treated DCs.	Curcumin	117-125	secreted phosphoprotein 1	Homo sapiens	13-16
26074974-7	2015	Curcumin pretreatment significantly increased cell viability and VEGF secretion, and decreased cell injury and apoptosis via regulation of PTEN/Akt/p53 and HO-1 signal proteins expression.	Curcumin	0-8	phosphatase and tensin homolog	Rattus norvegicus	139-143
24065177-8	2013	The results indicated that curcumin and BPS regulated invasion of SKOV3 cells and DCs by distinctly downregulating OPN, CD44 and MMP-9 expression.	Curcumin	27-35	secreted phosphoprotein 1	Homo sapiens	115-118
25530715-0	2014	The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway.	Curcumin	92-100	muscular LMNA interacting protein	Homo sapiens	139-142
24187456-0	2013	Curcumin cytotoxicity is enhanced by PTEN disruption in colorectal cancer cells.	Curcumin	0-8	phosphatase and tensin homolog	Homo sapiens	37-41
25407718-0	2014	Curcumin protects against CCl4-induced liver fibrosis in rats by inhibiting HIF-1alpha through an ERK-dependent pathway.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	76-86
25407718-9	2014	The alleviation with curcumin treatment was associated with inhibition of HIF-1alpha and phosphor-ERK.	Curcumin	21-29	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	74-84
25407718-10	2014	This study indicates that curcumin alleviates fibrosis by reducing the expression of HIF-1alpha partly through the ERK pathway.	Curcumin	26-34	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	85-95
18463970-6	2008	It is interesting to note that in vivo treatment with 15d-PGJ2 or curcumin results in a significant decrease in TLR4 and TLR9 expression in CD4(+) and CD8(+) T cells in association with the amelioration of EAE.	Curcumin	66-74	toll-like receptor 9	Mus musculus	121-125
18463970-6	2008	It is interesting to note that in vivo treatment with 15d-PGJ2 or curcumin results in a significant decrease in TLR4 and TLR9 expression in CD4(+) and CD8(+) T cells in association with the amelioration of EAE.	Curcumin	66-74	CD4 antigen	Mus musculus	140-143
18573304-2	2008	Curcumin, the major and most active antioxidant of Curcuma longa, protects neuronal cells against Abeta-induced toxicity.	Curcumin	0-8	amyloid beta precursor protein	Rattus norvegicus	98-103
24187456-8	2013	Using this set of cell lines, we found that disruption of the PTEN gene had no effect on the sensitivity of CRC cells to 5-FU, CPT-11, DHA, or OXA, whereas PTEN disruption increased the sensitivity of CRC cells to curcumin.	Curcumin	214-222	phosphatase and tensin homolog	Homo sapiens	156-160
18573304-3	2008	Therefore, in this study, we investigated the neuroprotective mechanisms by which curcumin acts against Abeta (25-35)-induced toxicity in PC12 cells.	Curcumin	82-90	amyloid beta precursor protein	Rattus norvegicus	104-109
18573304-5	2008	In addition, pretreatment of PC12 cells with 10 microg/ml curcumin for 1h significantly reversed the effect of Abeta, by decreasing the oxidative stress, and DNA damage induced by Abeta, as well as attenuating the elevation of intracellular calcium levels and tau hyperphosphorylation induced by Abeta.	Curcumin	58-66	amyloid beta precursor protein	Rattus norvegicus	111-116
25375374-5	2014	Natural polyphenolic compounds that are present in our diet, such as rottlerin, genistein, quercetin, curcumin, and resveratrol, can trigger type II PCD via various mechanisms through the canonical (Beclin-1 dependent) and non-canonical (Beclin-1 independent) routes of autophagy.	Curcumin	102-110	beclin 1	Homo sapiens	199-207
18573304-5	2008	In addition, pretreatment of PC12 cells with 10 microg/ml curcumin for 1h significantly reversed the effect of Abeta, by decreasing the oxidative stress, and DNA damage induced by Abeta, as well as attenuating the elevation of intracellular calcium levels and tau hyperphosphorylation induced by Abeta.	Curcumin	58-66	amyloid beta precursor protein	Rattus norvegicus	180-185
18573304-5	2008	In addition, pretreatment of PC12 cells with 10 microg/ml curcumin for 1h significantly reversed the effect of Abeta, by decreasing the oxidative stress, and DNA damage induced by Abeta, as well as attenuating the elevation of intracellular calcium levels and tau hyperphosphorylation induced by Abeta.	Curcumin	58-66	amyloid beta precursor protein	Rattus norvegicus	180-185
18660423-0	2008	Curcumin modulates SDF-1alpha/CXCR4-induced migration of human retinal endothelial cells (HRECs).	Curcumin	0-8	C-X-C motif chemokine receptor 4	Homo sapiens	30-35
18660423-2	2008	The purpose of this study was to assess whether curcumin inhibits human retinal endothelial cell (HREC) migration by interfering with SDF-1alpha/CXCR4 signaling.	Curcumin	48-56	C-X-C motif chemokine receptor 4	Homo sapiens	145-150
25375374-5	2014	Natural polyphenolic compounds that are present in our diet, such as rottlerin, genistein, quercetin, curcumin, and resveratrol, can trigger type II PCD via various mechanisms through the canonical (Beclin-1 dependent) and non-canonical (Beclin-1 independent) routes of autophagy.	Curcumin	102-110	beclin 1	Homo sapiens	238-246
24975470-0	2014	Curcumin protects neurons against oxygen-glucose deprivation/reoxygenation-induced injury through activation of peroxisome proliferator-activated receptor-gamma function.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	112-160
18660423-12	2008	In addition, curcumin significantly (P &lt; 0.001) decreased SDF-1alpha-induced HRECs migration and downregulated SDF-1alpha-induced expression of CXCR4, phospho-AKT, phospho-phosphatidylinositol-3-kinase (PI3-K), and eNOS.	Curcumin	13-21	C-X-C motif chemokine receptor 4	Homo sapiens	147-152
24187456-11	2013	In HCT116 PTEN (+/+) cells, curcumin caused a G2/M phase arrest, whereas it caused a G0/G1 phase arrest in HCT116 PTEN (-/-) cells.	Curcumin	28-36	phosphatase and tensin homolog	Homo sapiens	10-14
18565277-9	2008	Curcumin also inhibited the increase of the GPIIb/GPIIIa expression of thrombinactivated platelets in a concentration-dependent manner.	Curcumin	0-8	integrin subunit alpha 2b	Homo sapiens	44-49
24187456-13	2013	CONCLUSION: Curcumin shows enhanced cytotoxicity toward PTEN-deficient cancer cells, suggesting that it might be a potential chemotherapeutic agent for cancers harboring PTEN mutations.	Curcumin	12-20	phosphatase and tensin homolog	Homo sapiens	56-60
18386790-4	2008	Curcumin is incorporated into H-RS cells and acts inhibiting both NF-kappaB and STAT3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1, survivin, c-myc and cyclin D1.	Curcumin	0-8	X-linked inhibitor of apoptosis	Homo sapiens	217-221
24228095-11	2013	The expression of Bax and Caspase-3 were dramatically increased after 5-FU treatment (p&lt;0.01) and Curcumin treatment significantly reduced Bax expression (p&lt;0.05) but had only a moderate effect on reducing caspase-3 expression (p&gt;0.05).	Curcumin	101-109	BCL2 associated X, apoptosis regulator	Rattus norvegicus	142-145
18200517-10	2008	Secretion of IL-4 and IL-5 by CD4(+) lymphocytes of BALB/c mice but not SJL/J mice was significantly augmented by ConA and reduced to control levels by curcumin.	Curcumin	152-160	CD4 antigen	Mus musculus	30-33
24975470-2	2014	We previously demonstrated that curcumin activates peroxisome proliferator-activated receptor-gamma (PPARgamma), a ligand-activated transcription factor involved in both neuroprotective and anti-inflammatory signaling pathways.	Curcumin	32-40	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	51-99
24975470-2	2014	We previously demonstrated that curcumin activates peroxisome proliferator-activated receptor-gamma (PPARgamma), a ligand-activated transcription factor involved in both neuroprotective and anti-inflammatory signaling pathways.	Curcumin	32-40	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	101-110
24228095-14	2013	Curcumin also reduced the expression of pro-apoptotic Bax but stimulated anti-apoptotic Bcl-2 to attenuate 5-FU-induced apoptosis of intestinal epithelial cells.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	54-57
24975470-3	2014	This study tested whether the neuroprotective effects of curcumin against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced injury of rat cortical neurons are mediated (at least in part) by PPARgamma.	Curcumin	57-65	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	197-206
24975470-4	2014	Curcumin (10 muM) potently enhanced PPARgamma expression and transcriptional activity following OGD/R.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	36-45
24220325-0	2013	A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells.	Curcumin	14-22	transformation related protein 53, pseudogene	Mus musculus	81-84
24975470-8	2014	Again, GW9662 or PPARgamma siRNA transfection mitigated the protective effects of curcumin on mitochondrial function.	Curcumin	82-90	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	17-26
24975470-9	2014	Curcumin suppressed IkappaB kinase phosphorylation and IkappaB degradation, thereby inhibiting nuclear factor-kappa B (NF-kappaB) nuclear translocation, effects also blocked by GW9662 or PPARgamma siRNA.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	187-196
24975470-11	2014	The present study provides strong evidence that at least some of the neuroprotective effects of curcumin against OGD/R are mediated by PPARgamma activation.	Curcumin	96-104	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	135-144
25123790-5	2014	Moreover, curcumin was shown to induce phase II detoxifying/antioxidant enzymes HO-1 and NQO1 through the activation of nuclear factor erythroid-derived 2-like 2 (Nrf2).	Curcumin	10-18	NAD(P)H dehydrogenase, quinone 1	Mus musculus	89-93
18420184-0	2008	Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB.	Curcumin	0-8	brain-derived neurotrophic factor	Rattus norvegicus	98-131
18420184-4	2008	In the present study, we explored the effect of curcumin against glutamate excitotoxicity, mainly focusing on the neuroprotective effects of curcumin on the expression of Brain-Derived Neurotrophic Factor (BDNF), which is deeply involved in the etiology and treatment of depression.	Curcumin	141-149	brain-derived neurotrophic factor	Rattus norvegicus	171-204
18420184-4	2008	In the present study, we explored the effect of curcumin against glutamate excitotoxicity, mainly focusing on the neuroprotective effects of curcumin on the expression of Brain-Derived Neurotrophic Factor (BDNF), which is deeply involved in the etiology and treatment of depression.	Curcumin	141-149	brain-derived neurotrophic factor	Rattus norvegicus	206-210
18420184-6	2008	Pretreatment of neurons with curcumin reversed the BDNF expression and cell viability in a dose- and time-dependent manner.	Curcumin	29-37	brain-derived neurotrophic factor	Rattus norvegicus	51-55
18420184-7	2008	However, K252a, a Trk receptor inhibitor which is known to inhibit the activity of BDNF, could block the survival-promoting effect of curcumin.	Curcumin	134-142	brain-derived neurotrophic factor	Rattus norvegicus	83-87
18420184-8	2008	In addition, the up-regulation of BDNF levels by curcumin was also suppressed by K252a.	Curcumin	49-57	brain-derived neurotrophic factor	Rattus norvegicus	34-38
18420184-9	2008	Taken together, these results suggest that the neuroprotective effect of curcumin might be mediated via BDNF/TrkB signaling pathway.	Curcumin	73-81	brain-derived neurotrophic factor	Rattus norvegicus	104-108
18098290-6	2008	Tumor volume in the EGCG + curcumin treated mice decreased 49% compared to vehicle control mice (p &lt; 0.05), which correlated with a 78 +/- 6% decrease in levels of VEGFR-1 protein expression in the tumors.	Curcumin	27-35	FMS-like tyrosine kinase 1	Mus musculus	167-174
18394691-0	2008	Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk.	Curcumin	0-8	spleen tyrosine kinase	Mus musculus	117-120
18394691-8	2008	Similar concentrations of curcumin suppressed Syk-dependent phosphorylations of the adaptor proteins linker of activated T cells and Grb2-associated binder 2, which are critical for mast cell activation.	Curcumin	26-34	spleen tyrosine kinase	Mus musculus	46-49
25300360-10	2014	Mechanism studies revealed that CYP3A4 was markedly activated by curcumin metabolites, which apparently overrode the inhibition effects of curcumin on P-gp.	Curcumin	65-73	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	151-155
18394691-9	2008	Although curcumin did not inhibit the phosphorylation of Syk itself, it directly inhibited Syk kinase activity in vitro.	Curcumin	9-17	spleen tyrosine kinase	Mus musculus	91-94
24011306-7	2013	In conclusion, curcumin potently inhibits expression of LPS-induced inflammatory cytokines in macrophages via mechanisms that involve modulation of expression and activity of SOCS-1 and SOCS-3 and of p38 MAPK.	Curcumin	15-23	suppressor of cytokine signaling 3	Mus musculus	186-192
18394691-11	2008	CONCLUSIONS: Curcumin inhibits Syk kinase-dependent signaling events in mast cells and might thus contribute to its antiallergic activity.	Curcumin	13-21	spleen tyrosine kinase	Mus musculus	31-34
17902169-8	2008	Moreover, S1P-induced EGFR expression was inhibited by an AP-1 inhibitor curcumin and tanshinone IIA.	Curcumin	73-81	epidermal growth factor receptor	Rattus norvegicus	22-26
24422402-0	2013	[Effect of curcumin on expression of AKT and p-AKT in hippocampus CA1 area of App/PS1 double transgenic mice].	Curcumin	11-19	carbonic anhydrase 1	Mus musculus	66-69
18191976-2	2008	Curcumin is known to inhibit the histone acetyltransferase activity of the transcriptional coactivator proteins p300 and CBP, which are recruited to the immediate early (IE) gene promoters of herpes simplex virus type 1 (HSV-1) by the viral transactivator protein VP16.	Curcumin	0-8	host cell factor C1	Homo sapiens	264-268
18191976-10	2008	These results suggest that curcumin affects VP16-mediated recruitment of RNA polymerase II to IE gene promoters by a mechanism independent of p300/CBP histone acetyltransferase activity.	Curcumin	27-35	host cell factor C1	Homo sapiens	44-48
25300360-10	2014	Mechanism studies revealed that CYP3A4 was markedly activated by curcumin metabolites, which apparently overrode the inhibition effects of curcumin on P-gp.	Curcumin	139-147	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	151-155
25300360-11	2014	In conclusion, oral intake of curcumin significantly decreased the bioavailability of EVL, a probe substrate of P-gp/CYP 3A4, mainly through marked activation on CYP 3A4.	Curcumin	30-38	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	112-116
24422402-0	2013	[Effect of curcumin on expression of AKT and p-AKT in hippocampus CA1 area of App/PS1 double transgenic mice].	Curcumin	11-19	presenilin 1	Mus musculus	82-85
25299597-0	2014	Mass-spectrometric identification of T-kininogen I/thiostatin as an acute-phase inflammatory protein suppressed by curcumin and capsaicin.	Curcumin	115-123	kininogen 2	Rattus norvegicus	37-50
24422402-1	2013	OBJECTIVE: To observe the effect of curcumin on the expressions of AKT (serine-threonine kinase, AKT, also known as PKB) and p-AKT (phosphated serine-threonine kinase, p-AKT) in APP/PS1 double transgenic mice of the AD model.	Curcumin	36-44	presenilin 1	Mus musculus	182-185
25299597-0	2014	Mass-spectrometric identification of T-kininogen I/thiostatin as an acute-phase inflammatory protein suppressed by curcumin and capsaicin.	Curcumin	115-123	kininogen 2	Rattus norvegicus	51-61
25299597-8	2014	The results demonstrate that curcumin and capsaicin lower the acute-phase inflammatory response, the molecular mechanism for which is, in part, mediated by pathways associated with the lowering of T-kininogen I.	Curcumin	29-37	kininogen 2	Rattus norvegicus	197-210
17594054-0	2007	Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma.	Curcumin	0-8	inhibitor of growth family member 4	Homo sapiens	82-86
24422402-11	2013	Compared with the model group, AKT and p-AKT positive cells of hippocampus CA1 area increased obviously in the rosiglitazone group and high and medium dose curcumin group (P &lt;0.05 or P &lt;0.01) ,especially the medium dose group (P &lt;0.01).	Curcumin	156-164	carbonic anhydrase 1	Mus musculus	75-78
17594054-11	2007	Results of Western blot analysis demonstrated that ING4 expression was almost undetectable in U251 cells, but significantly up-regulated during cell cycle arrest induced by curcumin, and p53 expression was up-regulated followed by induction of p21 WAF-1/CIP-1 and ING4.	Curcumin	173-181	inhibitor of growth family member 4	Homo sapiens	51-55
23685326-9	2013	Curcumin also inhibited astrocyte activation as evidenced by decreased GFAP expression.	Curcumin	0-8	glial fibrillary acidic protein	Mus musculus	71-75
25211173-3	2014	In this study, we investigated the effect of curcumin treatment on hepatic heme oxygenase-1 (HO-1) expression along with pro-oxidant-antioxidant status and lipid accumulation in rats fed an HFD.	Curcumin	45-53	heme oxygenase 1	Rattus norvegicus	93-97
25211173-9	2014	These findings suggest that increased HO-1 expression, along with suppressed oxidative stress as well as reduced hepatic fat accumulation and fibrotic changes, contribute to the beneficial effects of curcumin in attenuating the pathogenesis of fatty liver induced metabolic diseases.	Curcumin	200-208	heme oxygenase 1	Rattus norvegicus	38-42
23685957-0	2013	Curcumin inhibits AP-2gamma-induced apoptosis in the human malignant testicular germ cells in vitro.	Curcumin	0-8	transcription factor AP-2 gamma	Homo sapiens	18-27
24938356-0	2014	Curcumin suppresses proliferation and invasion in non-small cell lung cancer by modulation of MTA1-mediated Wnt/beta-catenin pathway.	Curcumin	0-8	metastasis associated 1	Homo sapiens	94-98
24938356-2	2014	It has been previously demonstrated that curcumin can inhibit the invasion and metastasis of tumors through activation of the tumor suppressor DnaJ-like heat shock protein 40 (HLJ1).	Curcumin	41-49	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	143-174
24938356-2	2014	It has been previously demonstrated that curcumin can inhibit the invasion and metastasis of tumors through activation of the tumor suppressor DnaJ-like heat shock protein 40 (HLJ1).	Curcumin	41-49	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	176-180
17586469-4	2007	Expressed in COS-1 cells, mouse GI-distributed Ugt1a1 glucuronidates curcumin and MPA and undergoes irreversibly and reversibly dephosphorylation by PKC-specific inhibitor calphostin-C and general-kinase inhibitor curcumin, respectively, with parallel effects on activity.	Curcumin	69-77	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	47-53
17586469-4	2007	Expressed in COS-1 cells, mouse GI-distributed Ugt1a1 glucuronidates curcumin and MPA and undergoes irreversibly and reversibly dephosphorylation by PKC-specific inhibitor calphostin-C and general-kinase inhibitor curcumin, respectively, with parallel effects on activity.	Curcumin	214-222	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	47-53
17617388-0	2007	Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats.	Curcumin	0-8	brain-derived neurotrophic factor	Rattus norvegicus	97-130
17617388-10	2007	In addition, curcumin significantly prevented the stress-induced decrease in 5-HT(1A) mRNA and BDNF protein levels in the hippocampal subfields, two molecules involved in hippocampal neurogenesis.	Curcumin	13-21	brain-derived neurotrophic factor	Rattus norvegicus	95-99
17617388-12	2007	Moreover, curcumin treatment, via up-regulation of 5-HT(1A) receptors and BDNF, may reverse or protect hippocampal neurons from further damage in response to chronic stress, which may underlie the therapeutic actions of curcumin.	Curcumin	10-18	brain-derived neurotrophic factor	Rattus norvegicus	74-78
17617388-12	2007	Moreover, curcumin treatment, via up-regulation of 5-HT(1A) receptors and BDNF, may reverse or protect hippocampal neurons from further damage in response to chronic stress, which may underlie the therapeutic actions of curcumin.	Curcumin	220-228	brain-derived neurotrophic factor	Rattus norvegicus	74-78
24938356-6	2014	Our results showed that curcumin could effectively inhibit the MTA1 expression of NSCLC cells.	Curcumin	24-32	metastasis associated 1	Homo sapiens	63-67
24938356-7	2014	Further research on the subsequent mechanism showed that curcumin inhibited the proliferation and invasion of NSCLC cells through MTA1-mediated inactivation of Wnt/beta-catenin pathway.	Curcumin	57-65	metastasis associated 1	Homo sapiens	130-134
23685957-8	2013	Curcumin dose-dependently induced apoptosis of NTera-2 cells by reducing FasL expression and Bcl-2-to-Bax ratio, and activating caspase-9, -8 and -3.	Curcumin	0-8	Fas ligand	Homo sapiens	73-77
17603281-0	2007	Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells.	Curcumin	29-37	heme oxygenase 1	Rattus norvegicus	9-25
17603281-2	2007	In the present study, we investigated whether the phytochemical curcumin and its metabolite tetrahydrocurcumin could induce HO-1 expression and growth inhibition in rat VSMCs and, if so, whether their antiproliferative effect could be mediated via HO-1 expression.	Curcumin	64-72	heme oxygenase 1	Rattus norvegicus	124-128
23685957-8	2013	Curcumin dose-dependently induced apoptosis of NTera-2 cells by reducing FasL expression and Bcl-2-to-Bax ratio, and activating caspase-9, -8 and -3.	Curcumin	0-8	caspase 9	Homo sapiens	128-148
17603281-2	2007	In the present study, we investigated whether the phytochemical curcumin and its metabolite tetrahydrocurcumin could induce HO-1 expression and growth inhibition in rat VSMCs and, if so, whether their antiproliferative effect could be mediated via HO-1 expression.	Curcumin	64-72	heme oxygenase 1	Rattus norvegicus	248-252
17603281-3	2007	At non-toxic concentrations, curcumin possessing two Michael-reaction acceptors induced HO-1 expression by activating antioxidant response element (ARE) through translocation of the nuclear transcription factor E2-related factor-2 (Nrf2) into the nucleus and also inhibited VSMC growth triggered by 5% FBS in a dose-dependent manner.	Curcumin	29-37	heme oxygenase 1	Rattus norvegicus	88-92
25027711-6	2014	TPA-induced phosphorylation of Akt, S6 kinase (S6K), and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) in mouse skin was lower in the curcumin group than in the control group.	Curcumin	158-166	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	36-45
17603281-5	2007	The antiproliferative effect of curcumin in VSMCs was accompanied by the increased expression of p21(WAF1/CIP1).	Curcumin	32-40	KRAS proto-oncogene, GTPase	Rattus norvegicus	97-100
23685957-9	2013	Furthermore, curcumin dose-dependently reduced the expression of AP transcription factor AP-2gamma in NTera-2 cells, whereas the pretreatment with the proteasome inhibitor MG132 blocked both the curcumin-induced reduction of AP-2gamma and antiproliferative effect.	Curcumin	13-21	transcription factor AP-2 gamma	Homo sapiens	89-98
17603281-6	2007	Inhibition of VSMC growth and expression of p21(WAF1/CIP1) by curcumin were partially, but not completely, abolished when the cells were co- incubated with the HO inhibitor tin protoporphyrin.	Curcumin	62-70	KRAS proto-oncogene, GTPase	Rattus norvegicus	44-47
25027711-6	2014	TPA-induced phosphorylation of Akt, S6 kinase (S6K), and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) in mouse skin was lower in the curcumin group than in the control group.	Curcumin	158-166	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	47-50
25027711-7	2014	Curcumin treatment inhibited IGF-1-induced phosphorylation of the IGF-1 receptor, insulin receptor substrate-1, Akt, S6K, and 4EBP1 in the mouse keratinocyte cell line, C50 in a dose-dependent manner.	Curcumin	0-8	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	117-131
17603281-8	2007	Our findings suggest that curcumin has an ability to induce HO-1 expression, presumably through Nrf2-dependent ARE activation, in rat VSMCs and HASMCs, and provide evidence that the antiproliferative effect of curcumin is considerably linked to its ability to induce HO-1 expression.	Curcumin	26-34	heme oxygenase 1	Rattus norvegicus	60-64
17603281-8	2007	Our findings suggest that curcumin has an ability to induce HO-1 expression, presumably through Nrf2-dependent ARE activation, in rat VSMCs and HASMCs, and provide evidence that the antiproliferative effect of curcumin is considerably linked to its ability to induce HO-1 expression.	Curcumin	26-34	heme oxygenase 1	Rattus norvegicus	267-271
25064633-9	2014	Curcumin also enhanced RCT via up-regulating the expression of liver X receptor alpha (LXRalpha), ATP-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type I (SR-BI).	Curcumin	0-8	ATP binding cassette subfamily A member 1	Homo sapiens	98-133
23685957-9	2013	Furthermore, curcumin dose-dependently reduced the expression of AP transcription factor AP-2gamma in NTera-2 cells, whereas the pretreatment with the proteasome inhibitor MG132 blocked both the curcumin-induced reduction of AP-2gamma and antiproliferative effect.	Curcumin	195-203	transcription factor AP-2 gamma	Homo sapiens	89-98
25064633-9	2014	Curcumin also enhanced RCT via up-regulating the expression of liver X receptor alpha (LXRalpha), ATP-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type I (SR-BI).	Curcumin	0-8	ATP binding cassette subfamily A member 1	Homo sapiens	135-140
25064633-9	2014	Curcumin also enhanced RCT via up-regulating the expression of liver X receptor alpha (LXRalpha), ATP-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type I (SR-BI).	Curcumin	0-8	scavenger receptor class B member 1	Homo sapiens	146-179
17603281-8	2007	Our findings suggest that curcumin has an ability to induce HO-1 expression, presumably through Nrf2-dependent ARE activation, in rat VSMCs and HASMCs, and provide evidence that the antiproliferative effect of curcumin is considerably linked to its ability to induce HO-1 expression.	Curcumin	210-218	heme oxygenase 1	Rattus norvegicus	60-64
17603281-8	2007	Our findings suggest that curcumin has an ability to induce HO-1 expression, presumably through Nrf2-dependent ARE activation, in rat VSMCs and HASMCs, and provide evidence that the antiproliferative effect of curcumin is considerably linked to its ability to induce HO-1 expression.	Curcumin	210-218	heme oxygenase 1	Rattus norvegicus	267-271
25064633-9	2014	Curcumin also enhanced RCT via up-regulating the expression of liver X receptor alpha (LXRalpha), ATP-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type I (SR-BI).	Curcumin	0-8	scavenger receptor class B member 1	Homo sapiens	181-186
17289836-9	2007	Because expression of antiapoptotic Bcl-2, Bcl-xL, and X-chromosome-linked inhibitor of apoptosis protein (XIAP) is regulated by NF-kappaB, both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB.	Curcumin	145-153	X-linked inhibitor of apoptosis	Homo sapiens	55-105
17289836-9	2007	Because expression of antiapoptotic Bcl-2, Bcl-xL, and X-chromosome-linked inhibitor of apoptosis protein (XIAP) is regulated by NF-kappaB, both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB.	Curcumin	145-153	X-linked inhibitor of apoptosis	Homo sapiens	107-111
17289836-11	2007	Collectively, these data define a pathway whereby curcumin sensitizes prostate cancer cells to TRAIL by inhibiting Akt-regulated NF-kappaB and NF-kappaB-dependent antiapoptotic Bcl-2, Bcl-xL, and XIAP.	Curcumin	50-58	X-linked inhibitor of apoptosis	Homo sapiens	196-200
17372590-7	2007	Curcumin interrupts PDGF and EGF signaling demonstrated by inhibiting tyrosine phosphorylation of PDGF-betaR and EGFR and by reducing the levels of phosphorylated phosphatidylinositol-3 kinase (PI-3K/AKT), extracellular signal-regulated kinase (ERK) and the Jun N-terminal kinase (JNK).	Curcumin	0-8	epidermal growth factor receptor	Rattus norvegicus	113-117
25064633-11	2014	CONCLUSION: Curcumin suppresses MCP-1 production induced by ox-LDL via the JNK pathway and NK-kappaB pathway, while enhances cholesterol efflux in macrophage via suppressing the JNK pathway and activating the LXR-ABCA1/SR-BI pathway, which indicate that the vascular protective effect of curcumin is related to anti-inflammation and anti-atherosclerosis.	Curcumin	12-20	ATP binding cassette subfamily A member 1	Homo sapiens	213-218
25064633-11	2014	CONCLUSION: Curcumin suppresses MCP-1 production induced by ox-LDL via the JNK pathway and NK-kappaB pathway, while enhances cholesterol efflux in macrophage via suppressing the JNK pathway and activating the LXR-ABCA1/SR-BI pathway, which indicate that the vascular protective effect of curcumin is related to anti-inflammation and anti-atherosclerosis.	Curcumin	12-20	scavenger receptor class B member 1	Homo sapiens	219-224
17372590-9	2007	Our results collectively demonstrate that the interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in activated HSC.	Curcumin	101-109	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	140-149
23685957-9	2013	Furthermore, curcumin dose-dependently reduced the expression of AP transcription factor AP-2gamma in NTera-2 cells, whereas the pretreatment with the proteasome inhibitor MG132 blocked both the curcumin-induced reduction of AP-2gamma and antiproliferative effect.	Curcumin	195-203	transcription factor AP-2 gamma	Homo sapiens	225-234
17372590-10	2007	These results provide novel insights into the mechanisms of curcumin in the induction of PPARgamma gene expression in activated HSC.	Curcumin	60-68	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	89-98
23685957-11	2013	CONCLUSION: Curcumin induces apoptosis and inhibits proliferation in NTera-2 cells via the inhibition of AP-2gamma-mediated downstream cell survival signaling pathways.	Curcumin	12-20	transcription factor AP-2 gamma	Homo sapiens	105-114
17650800-0	2007	[Effect of curcumin on activity of matrix metalloproteinase 2, 9 and nuclear expression of RelA in rat hepatic stellate cells by activating peroxisome proliferator-activated receptor gamma signal].	Curcumin	11-19	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	140-188
17650800-1	2007	OBJECTIVE: To study the effect of curcumin on the activity of matrix metalloproteinases (MMPs) and nuclear expression of RelA in rat hepatic stellate cells (HSCs) by activating peroxisome proliferator-activated receptor gamma (PPARgamma) signal in vitro.	Curcumin	34-42	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	177-225
17650800-4	2007	RESULTS: The PPARgamma expression decreased gradually with increasing of HSC activation, which was up-regulated by curcumin (P &lt; 0.01); curcumin inhibited the expression of aSMA, the production of collagen type I, and the nuclear expression of activated RelA (P &lt; 0.01), and elevated the activity of MMP2 and MMP9 significantly (P &lt; 0.01).	Curcumin	115-123	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	13-22
17650800-4	2007	RESULTS: The PPARgamma expression decreased gradually with increasing of HSC activation, which was up-regulated by curcumin (P &lt; 0.01); curcumin inhibited the expression of aSMA, the production of collagen type I, and the nuclear expression of activated RelA (P &lt; 0.01), and elevated the activity of MMP2 and MMP9 significantly (P &lt; 0.01).	Curcumin	139-147	matrix metallopeptidase 9	Rattus norvegicus	315-319
23812632-8	2013	Curcumin effectively blocked hyperoxia-induced lung injury based on systematic analysis of markers for lung injury (apoptosis, Bcl-2/Bax, collagen III, fibronectin, vimentin, calponin, and elastin-related genes) and lung morphology (radial alveolar count and alveolar septal thickness).	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	133-136
17650800-6	2007	CONCLUSION: By activating PPARgamma signal transduction pathway curcumin treatment can inhibit HSC activation, increase the activity of MMP2 and MMP9 and inhibit/ interfere nuclear translocation of NFkappaB.	Curcumin	64-72	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	26-35
17650800-6	2007	CONCLUSION: By activating PPARgamma signal transduction pathway curcumin treatment can inhibit HSC activation, increase the activity of MMP2 and MMP9 and inhibit/ interfere nuclear translocation of NFkappaB.	Curcumin	64-72	matrix metallopeptidase 9	Rattus norvegicus	145-149
24914461-9	2014	Taken together, our results indicate that the antidepressant-like effects of curcumin in CUS rats are related to its aptitude to promote BDNF and ERK in the hippocampus.	Curcumin	77-85	brain-derived neurotrophic factor	Rattus norvegicus	137-141
25136316-7	2014	In addition, curcumin with its versatile activities modulated the expression of many oxidative stress-regulating genes such as PDGF, VEGF, IGFBP-2, HO1, SOD2, and GPX1.	Curcumin	13-21	glutathione peroxidase 1	Homo sapiens	163-167
21179765-0	2007	[The relationship between the effects of curcumin on cerebral ischemia/reperfusion injury and immediately genic expressions of fos, Jun and NF-kappaB in hippocampal CA1 area and its significance in gerbils].	Curcumin	41-49	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	127-130
21179765-0	2007	[The relationship between the effects of curcumin on cerebral ischemia/reperfusion injury and immediately genic expressions of fos, Jun and NF-kappaB in hippocampal CA1 area and its significance in gerbils].	Curcumin	41-49	carbonic anhydrase 1	Homo sapiens	165-168
23812632-8	2013	Curcumin effectively blocked hyperoxia-induced lung injury based on systematic analysis of markers for lung injury (apoptosis, Bcl-2/Bax, collagen III, fibronectin, vimentin, calponin, and elastin-related genes) and lung morphology (radial alveolar count and alveolar septal thickness).	Curcumin	0-8	fibronectin 1	Rattus norvegicus	152-163
21179765-1	2007	AIM: To explore the relationship between the effects of curcumin on cerebral ischemic/reperfusion injury and immediately genic expressions of Fos, Jun and NF-kappaB in hippocampal CA1 area.	Curcumin	56-64	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	142-145
21179765-1	2007	AIM: To explore the relationship between the effects of curcumin on cerebral ischemic/reperfusion injury and immediately genic expressions of Fos, Jun and NF-kappaB in hippocampal CA1 area.	Curcumin	56-64	carbonic anhydrase 1	Homo sapiens	180-183
23977989-0	2013	Curcumin ameliorates TNF-alpha-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	112-128
21179765-6	2007	CONCLUSION: Curcumin can significantly protect neurons against cerebral ischemia, increasing the expression Fos and decreasing the expression of Jun and NF-kappaB may be the protective mechanisms.	Curcumin	12-20	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	108-111
17569214-3	2007	Subsequently, curcumin inhibits the activation of NF-KB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs, and iNOS.	Curcumin	14-22	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	99-104
17569214-3	2007	Subsequently, curcumin inhibits the activation of NF-KB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs, and iNOS.	Curcumin	14-22	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-111
17050652-0	2007	Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in rats.	Curcumin	10-18	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	38-52
24702912-4	2014	PL9 and PL6 were used for loading model drug curcumin.	Curcumin	45-53	transmembrane protein 115	Homo sapiens	8-11
24920381-0	2014	SAR studies on curcumin"s pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.	Curcumin	15-23	arachidonate 5-lipoxygenase	Mus musculus	141-155
24920381-1	2014	The anticarcinogenic and anti-inflammatory properties of curcumin have been extensively investigated, identifying prostaglandin E2 synthase (mPGES)-1 and 5-lipoxygenase (5-LO), key enzymes linking inflammation with cancer, as high affinity targets.	Curcumin	57-65	arachidonate 5-lipoxygenase	Mus musculus	154-168
17050652-1	2007	The aim of this study was to evaluate whether curcumin could modulate P-glycoprotein (P-gp) and CYP3A expression, and in turn modify the pharmacokinetic profiles of P-gp and CYP3A substrates in male Sprague-Dawley rats.	Curcumin	46-54	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	70-84
17050652-1	2007	The aim of this study was to evaluate whether curcumin could modulate P-glycoprotein (P-gp) and CYP3A expression, and in turn modify the pharmacokinetic profiles of P-gp and CYP3A substrates in male Sprague-Dawley rats.	Curcumin	46-54	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	86-90
23977989-3	2013	Curcumin induced expression of heme oxygenase-1 (HO-1) in the human keratinocyte cell line HaCaT.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	31-47
17050652-1	2007	The aim of this study was to evaluate whether curcumin could modulate P-glycoprotein (P-gp) and CYP3A expression, and in turn modify the pharmacokinetic profiles of P-gp and CYP3A substrates in male Sprague-Dawley rats.	Curcumin	46-54	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	165-169
17050652-2	2007	Intragastric gavage of the rats with 60 mg/kg curcumin for 4 consecutive days led to a down-regulation of the intestinal P-gp level.	Curcumin	46-54	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	121-125
23977989-3	2013	Curcumin induced expression of heme oxygenase-1 (HO-1) in the human keratinocyte cell line HaCaT.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	49-53
17050652-5	2007	Regular curcumin consumption also caused the C(max) and area under the concentration-time curve (AUC(0-8) and total AUC) of peroral celiprolol (a P-gp substrate with negligible cytochrome P450 metabolism) at 30 mg/kg to increase, but the apparent oral clearance (CL(oral)) of the drug was reduced.	Curcumin	8-16	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	146-150
17050652-6	2007	Similarly, rats treated with curcumin for 4 consecutive days showed higher AUC (AUC(0-4) and total AUC) and lower CL(oral) for peroral midazolam (a CYP3A substrate that does not interact with the P-gp) at 20 mg/kg in comparison with vehicle-treated rats.	Curcumin	29-37	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	196-200
23977989-5	2013	Curcumin suppressed TNF-alpha- induced ICAM-1 expression and subsequent monocyte adhesion, which were reversed by the addition of tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, or HO-1 knockdown using siRNA.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	184-188
24901506-0	2014	Biological activity and molecular docking studies of curcumin-related alpha,beta-unsaturated carbonyl-based synthetic compounds as anticancer agents and mushroom tyrosinase inhibitors.	Curcumin	53-61	tyrosinase	Homo sapiens	162-172
23977989-5	2013	Curcumin suppressed TNF-alpha- induced ICAM-1 expression and subsequent monocyte adhesion, which were reversed by the addition of tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, or HO-1 knockdown using siRNA.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	193-197
17050652-8	2007	Analysis of the data suggests that the changes in the pharmacokinetic profiles of peroral celiprolol and midazolam in the rat model were contributed mainly by the curcumin-mediated down-regulation of intestinal P-gp and CYP3A protein levels, respectively.	Curcumin	163-171	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	211-215
23977989-7	2013	These results suggest that curcumin may exert its anti-inflammatory activity by suppressing the TNF-alpha-induced ICAM-1 expression and subsequent monocyte adhesion via expression of HO-1 in the keratinocytes.	Curcumin	27-35	heme oxygenase 1	Homo sapiens	183-187
23946685-5	2013	Radiation-induced transforming growth factor-beta1 (TGF-beta1), connective tissue growth factor (CTGF) expression, and collagen accumulation were also inhibited by curcumin.	Curcumin	164-172	cellular communication network factor 2	Rattus norvegicus	64-95
24714399-0	2014	Inhibition of JNK by novel curcumin analog C66 prevents diabetic cardiomyopathy with a preservation of cardiac metallothionein expression.	Curcumin	27-35	mitogen-activated protein kinase 8	Mus musculus	14-17
23946685-5	2013	Radiation-induced transforming growth factor-beta1 (TGF-beta1), connective tissue growth factor (CTGF) expression, and collagen accumulation were also inhibited by curcumin.	Curcumin	164-172	cellular communication network factor 2	Rattus norvegicus	97-101
24714399-2	2014	The present study tested a hypothesis whether the curcumin analog C66 [(2E,6E)-2,6-bis(2-(trifluoromethyl)benzylidene) cyclohexanone] as a potent antioxidant can protect diabetes-induced cardiac functional and pathogenic changes via inhibition of JNK function.	Curcumin	50-58	mitogen-activated protein kinase 8	Mus musculus	247-250
16978906-5	2007	Moreover, this effect was suppressed by curcumin, a c-Jun N terminal kinase inhibitor, and was absent when the Activator protein-1 cis-regulatory element was deleted.	Curcumin	40-48	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-57
24325063-7	2013	Intervention by curcumin significantly inhibited the proliferation and migration of hypoxic HepG2 cells, and expressions of HIF-1alpha and vimentin decreased, and the expression of E-cadherin was up-regulated, showing statistical difference when compared with those of the CoCl2 group (P &lt; 0.05).	Curcumin	16-24	vimentin	Homo sapiens	139-147
16978906-5	2007	Moreover, this effect was suppressed by curcumin, a c-Jun N terminal kinase inhibitor, and was absent when the Activator protein-1 cis-regulatory element was deleted.	Curcumin	40-48	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	111-130
24675438-5	2014	Curcumin application increased the wound contraction and decreased the expressions of inflammatory cytokines/enzymes i.e. tumor necrosis factor-alpha, interleukin (IL)-1beta and matrix metalloproteinase-9.	Curcumin	0-8	matrix metallopeptidase 9	Rattus norvegicus	178-204
24482305-6	2014	Furthermore, curcumin treatment significantly decreased the percentage of CD4(+) T helper cells in EAN spleen and suppressed concanavalin A-induced lymphocyte proliferation in vitro.	Curcumin	13-21	Cd4 molecule	Rattus norvegicus	74-77
24482305-7	2014	In addition, curcumin altered helper T cell differentiation by decreasing IFN-gamma(+) CD4(+) Th1 cells in EAN lymph node and spleen.	Curcumin	13-21	Cd4 molecule	Rattus norvegicus	87-90
17182546-0	2007	Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth.	Curcumin	48-56	spleen tyrosine kinase	Mus musculus	24-27
17182546-6	2007	We identified a novel target for curcumin in B lymphoma viz spleen tyrosine kinase (Syk).	Curcumin	33-41	spleen tyrosine kinase	Mus musculus	84-87
17182546-7	2007	Syk is constitutively activated in primary tumors and B lymphoma cell lines and curcumin down-modulates Syk activity accompanied by down-regulation of Akt activation.	Curcumin	80-88	spleen tyrosine kinase	Mus musculus	0-3
17182546-7	2007	Syk is constitutively activated in primary tumors and B lymphoma cell lines and curcumin down-modulates Syk activity accompanied by down-regulation of Akt activation.	Curcumin	80-88	spleen tyrosine kinase	Mus musculus	104-107
23580183-0	2013	Comparative in silico-in vivo evaluation of ASGP-R ligands for hepatic targeting of curcumin Gantrez nanoparticles.	Curcumin	84-92	mucin 4, cell surface associated	Rattus norvegicus	44-48
23549752-6	2013	Using fluorescence measurements and flow cytometry in mouse lung microvascular endothelial cell culture homogenates, we determined that NLC rendered fluorescent by curcumin labeling are taken up by endothelial cells from mice expressing caveolin-1, the coat protein of caveolar endocytic vesicles, but not from caveolin-1 gene-disrupted mice, which lack caveolae.	Curcumin	164-172	caveolin 1, caveolae protein	Mus musculus	237-247
16782535-0	2006	Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	90-138
16782535-11	2006	The expression levels of PPARgamma, 15-deoxy-D12,14-prostaglandin J(2) (15d-PGJ(2)) and prostaglandin E(2) (PGE(2)) were all increased, but the expression level of cyclooxygenase-2 (COX-2) was decreased in rats after administration of curcumin.	Curcumin	235-243	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	25-34
16782535-14	2006	In summary, curcumin showed therapeutic effects on TNBS-induced colitis and the mechanisms by which curcumin exerts its effects may involve activation of PPARgamma and its ligands.	Curcumin	12-20	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	154-163
16782535-14	2006	In summary, curcumin showed therapeutic effects on TNBS-induced colitis and the mechanisms by which curcumin exerts its effects may involve activation of PPARgamma and its ligands.	Curcumin	100-108	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	154-163
16715036-0	2006	The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma.	Curcumin	32-40	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	108-156
16715036-14	2006	Moreover, the down-regulated PPAR-gamma in the liver at 20 hrs after CLP was significantly improved by curcumin treatment.	Curcumin	103-111	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	29-39
16715036-15	2006	Concurrent administration of curcumin and GW9662, a specific PPAR-gamma antagonist, completely abolished the beneficial effects of curcumin under such conditions.	Curcumin	29-37	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	61-71
16715036-15	2006	Concurrent administration of curcumin and GW9662, a specific PPAR-gamma antagonist, completely abolished the beneficial effects of curcumin under such conditions.	Curcumin	131-139	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	61-71
16715036-19	2006	The beneficial effect of curcumin appears to be mediated by up-regulation of nuclear receptor PPAR-gamma.	Curcumin	25-33	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	94-104
24936217-8	2014	Lastly, we identified derivatives of curcumin as in vitro inhibitors of JMJD2 enzymes, suggesting that these curcuminoids could be useful for decreasing JMJD2 activity in vivo.	Curcumin	37-45	lysine demethylase 4A	Homo sapiens	72-77
24936217-8	2014	Lastly, we identified derivatives of curcumin as in vitro inhibitors of JMJD2 enzymes, suggesting that these curcuminoids could be useful for decreasing JMJD2 activity in vivo.	Curcumin	37-45	lysine demethylase 4A	Homo sapiens	153-158
24438326-7	2014	The addition of curcumin suppressed nuclear AIF and EndoG and reversed anti-cancer drugs-induced NF-kappaB expression, suggesting the association of EndoG and NF-kappaB in curcumin-enhanced chemosensitivity.	Curcumin	16-24	apoptosis inducing factor mitochondria associated 1	Homo sapiens	44-47
24438326-7	2014	The addition of curcumin suppressed nuclear AIF and EndoG and reversed anti-cancer drugs-induced NF-kappaB expression, suggesting the association of EndoG and NF-kappaB in curcumin-enhanced chemosensitivity.	Curcumin	16-24	endonuclease G	Homo sapiens	52-57
24438326-7	2014	The addition of curcumin suppressed nuclear AIF and EndoG and reversed anti-cancer drugs-induced NF-kappaB expression, suggesting the association of EndoG and NF-kappaB in curcumin-enhanced chemosensitivity.	Curcumin	16-24	endonuclease G	Homo sapiens	149-154
24438326-7	2014	The addition of curcumin suppressed nuclear AIF and EndoG and reversed anti-cancer drugs-induced NF-kappaB expression, suggesting the association of EndoG and NF-kappaB in curcumin-enhanced chemosensitivity.	Curcumin	172-180	endonuclease G	Homo sapiens	149-154
24614199-7	2014	We recently reported that AGEs stimulated HSC activation likely by inhibiting gene expression of AGE-R1 and inducing gene expression of RAGE in HSC, which were eliminated by the antioxidant curcumin.	Curcumin	190-198	advanced glycosylation end-product specific receptor	Homo sapiens	136-140
24614199-12	2014	In conclusions, curcumin eliminated the effects of AGEs on the divergent regulation of gene expression of RAGE and AGE-R1 in HSC by interrupting the AGE-caused activation of leptin signaling, leading to the inhibition of HSC activation.	Curcumin	16-24	advanced glycosylation end-product specific receptor	Homo sapiens	106-110
23192861-0	2014	Suppressing the formation of lipid raft-associated Rac1/PI3K/Akt signaling complexes by curcumin inhibits SDF-1alpha-induced invasion of human esophageal carcinoma cells.	Curcumin	88-96	Rac family small GTPase 1	Homo sapiens	51-55
23192861-4	2014	Curcumin suppressed SDF-1alpha-induced cell invasion and matrix metalloproteinase-2 (MMP-2) promoter activity, cell surface localization of CXCR4 at lipid rafts, and lipid raft-associated ras-related C3 botulinum toxin substrate 1 (Rac1)/phosphatidylinositol 3-kinase (PI3K) p85alpha/Akt signaling.	Curcumin	0-8	C-X-C motif chemokine receptor 4	Homo sapiens	140-145
23192861-4	2014	Curcumin suppressed SDF-1alpha-induced cell invasion and matrix metalloproteinase-2 (MMP-2) promoter activity, cell surface localization of CXCR4 at lipid rafts, and lipid raft-associated ras-related C3 botulinum toxin substrate 1 (Rac1)/phosphatidylinositol 3-kinase (PI3K) p85alpha/Akt signaling.	Curcumin	0-8	Rac family small GTPase 1	Homo sapiens	232-236
23549752-6	2013	Using fluorescence measurements and flow cytometry in mouse lung microvascular endothelial cell culture homogenates, we determined that NLC rendered fluorescent by curcumin labeling are taken up by endothelial cells from mice expressing caveolin-1, the coat protein of caveolar endocytic vesicles, but not from caveolin-1 gene-disrupted mice, which lack caveolae.	Curcumin	164-172	caveolin 1, caveolae protein	Mus musculus	311-321
23192861-5	2014	Curcumin inhibited SDF-1alpha-induced cell invasion by suppressing the Rac1-PI3K signaling complex at lipid rafts but did not abrogate lipid raft formation.	Curcumin	0-8	Rac family small GTPase 1	Homo sapiens	71-75
23192861-6	2014	We further demonstrate that the attenuation of lipid raft-associated Rac1 activity by curcumin was critical for the inhibition of SDF-1alpha-induced PI3K/Akt/NF-kappaB activation, cell surface localization of CXCR4 at lipid rafts, MMP-2 promoter activity, and cell invasion.	Curcumin	86-94	Rac family small GTPase 1	Homo sapiens	69-73
23192861-6	2014	We further demonstrate that the attenuation of lipid raft-associated Rac1 activity by curcumin was critical for the inhibition of SDF-1alpha-induced PI3K/Akt/NF-kappaB activation, cell surface localization of CXCR4 at lipid rafts, MMP-2 promoter activity, and cell invasion.	Curcumin	86-94	C-X-C motif chemokine receptor 4	Homo sapiens	209-214
23192861-7	2014	Collectively, our results indicate that curcumin inhibits SDF-1alpha-induced EC cell invasion by suppressing the formation of the lipid raft-associated Rac1-PI3K-Akt signaling complex, the localization of CXCR4 with lipid rafts at the cell surface, and MMP-2 promoter activity, likely through the inhibition of Rac1 activity.	Curcumin	40-48	Rac family small GTPase 1	Homo sapiens	152-156
16551633-5	2006	The nuclear residence of RXRalpha is maintained by inhibiting c-jun N-terminal kinase (JNK, curcumin or SP600125) or CRM-1-mediated nuclear export (Leptomycin B).	Curcumin	92-100	retinoid X receptor alpha	Homo sapiens	25-33
16630125-6	2006	Curcumin reduced phosphorylation of PDK1 and inhibited constitutive activation of Akt.	Curcumin	0-8	pyruvate dehydrogenase kinase 1	Homo sapiens	36-40
23825622-6	2013	Real-time PCR showed that mRNA levels of IL-17A, IL-17F, IL-22, IL-1beta, IL-6 and TNF-alpha cytokines were decreased significantly by curcumin in ear skin, an effect similar to that of clobetasol.	Curcumin	135-143	interleukin 17F	Mus musculus	49-55
23825622-6	2013	Real-time PCR showed that mRNA levels of IL-17A, IL-17F, IL-22, IL-1beta, IL-6 and TNF-alpha cytokines were decreased significantly by curcumin in ear skin, an effect similar to that of clobetasol.	Curcumin	135-143	interleukin 22	Mus musculus	57-62
16648566-3	2006	We identified four inhibitors, including three protein kinase inhibitors (wortmannin, H-9, and alsterpaullone) and one natural compound (curcumin) that inhibit the FA/BRCA pathway.	Curcumin	137-145	BRCA1 DNA repair associated	Homo sapiens	167-171
26770672-2	2013	Herein, we confirmed that curcumin induces human neutrophil apoptosis as assessed by cytology and by increase in the cell surface expression of annexin-V and CD16 shedding.	Curcumin	26-34	annexin A5	Homo sapiens	144-153
16648566-4	2006	We show that curcumin, a compound that is generally regarded as safe, inhibits the monoubiquitination of the FANCD2 protein as predicted by the screen and consequently sensitizes ovarian and breast tumor cell lines to cisplatin through apoptotic cell death.	Curcumin	13-21	FA complementation group D2	Homo sapiens	109-115
16677086-2	2006	We had previously shown that curcumin, the yellow pigment in curry, strongly induced HO-1 expression and activity in rat astrocytes.	Curcumin	29-37	heme oxygenase 1	Rattus norvegicus	85-89
16677086-4	2006	Treatment of astrocytes with curcumin upregulated expression of HO-1 protein at both cytoplasmic and nuclear levels, as shown by immunofluorescence analysis under laser-scanning confocal microscopy.	Curcumin	29-37	heme oxygenase 1	Rattus norvegicus	64-68
16677086-6	2006	Moreover, the effects of curcumin on HO-1 activity were explored in cultured hippocampal neurons.	Curcumin	25-33	heme oxygenase 1	Rattus norvegicus	37-41
23192861-7	2014	Collectively, our results indicate that curcumin inhibits SDF-1alpha-induced EC cell invasion by suppressing the formation of the lipid raft-associated Rac1-PI3K-Akt signaling complex, the localization of CXCR4 with lipid rafts at the cell surface, and MMP-2 promoter activity, likely through the inhibition of Rac1 activity.	Curcumin	40-48	C-X-C motif chemokine receptor 4	Homo sapiens	205-210
23192861-7	2014	Collectively, our results indicate that curcumin inhibits SDF-1alpha-induced EC cell invasion by suppressing the formation of the lipid raft-associated Rac1-PI3K-Akt signaling complex, the localization of CXCR4 with lipid rafts at the cell surface, and MMP-2 promoter activity, likely through the inhibition of Rac1 activity.	Curcumin	40-48	Rac family small GTPase 1	Homo sapiens	311-315
24692720-5	2014	RESULTS: At non-cytotoxic concentrations, curcumin inhibited VM, reduced cell migration and MMP9 production of the HCC cells.	Curcumin	42-50	matrix metallopeptidase 9	Homo sapiens	92-96
24501322-8	2014	Dietary curcumin increased hepatic CYP1A and CYP1B1 activities without any effect on CYP3A4 activity, whereas curcumin implants increased both CYP1A and CYP3A4 activities but decreased CYP1B1 activity in the presence of E2.	Curcumin	8-16	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	45-51
24501322-8	2014	Dietary curcumin increased hepatic CYP1A and CYP1B1 activities without any effect on CYP3A4 activity, whereas curcumin implants increased both CYP1A and CYP3A4 activities but decreased CYP1B1 activity in the presence of E2.	Curcumin	110-118	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	185-191
16677086-7	2006	Elevated expression of HO-1 mRNA and protein were detected after 6 h incubation with 5-25 microM curcumin.	Curcumin	97-105	heme oxygenase 1	Rattus norvegicus	23-27
26770672-3	2013	Curcumin activated caspase-3 and the cleavage of the two cytoskeletal proteins lamin B1 and vimentin.	Curcumin	0-8	vimentin	Homo sapiens	92-100
24501322-9	2014	Because CYP1A and CYP3A4 metabolize most of the E2 to its noncarcinogenic 2-OH metabolite, and CYP1B1 produces potentially carcinogenic 4-OH metabolite, favorable modulation of these CYPs via systemically delivered curcumin could be one of the potential mechanisms.	Curcumin	215-223	cytochrome P450, family 1, subfamily b, polypeptide 1	Rattus norvegicus	95-101
23548270-10	2013	We found that curcumin administration increased miR-145 promoter activity, thereby decreasing SOX9/ADAM17 expression and eliminating TICs in HNC cell populations.	Curcumin	14-22	microRNA 145	Homo sapiens	48-55
24669820-0	2014	Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-kappaB signaling pathway in experimental traumatic brain injury.	Curcumin	0-8	myeloid differentiation primary response gene 88	Mus musculus	69-74
24669820-11	2014	Furthermore, Western blot analysis indicated that the levels of TLR4 and its known downstream effectors (MyD88, and NF-kappaB) were also decreased after curcumin treatment.	Curcumin	153-161	myeloid differentiation primary response gene 88	Mus musculus	105-110
24669820-14	2014	The increased protein levels of TLR4, MyD88 and NF-kappaB in microglia were attenuated by curcumin treatment.	Curcumin	90-98	myeloid differentiation primary response gene 88	Mus musculus	38-43
23548270-13	2013	Collectively, our results show how miR-145 targets the SOX9/ADAM17 axis to regulate TIC properties in HNC, and how altering this pathway may partly explain the anticancer effects of curcumin.	Curcumin	182-190	microRNA 145	Homo sapiens	35-42
16483311-0	2006	Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda.	Curcumin	27-35	DNA polymerase lambda	Homo sapiens	84-105
23192708-10	2013	Besides these effects, we found curcumin to be inhibiting telomerase activity and down-regulating hTERT mRNA expression leading to telomere shortening.	Curcumin	32-40	telomerase reverse transcriptase	Homo sapiens	98-103
16483311-1	2006	We previously reported that phenolic compounds, petasiphenol and curcumin (diferuloylmethane), were a selective inhibitor of DNA polymerase lambda (pol lambda) in vitro.	Curcumin	65-73	DNA polymerase lambda	Homo sapiens	125-146
16483311-1	2006	We previously reported that phenolic compounds, petasiphenol and curcumin (diferuloylmethane), were a selective inhibitor of DNA polymerase lambda (pol lambda) in vitro.	Curcumin	75-92	DNA polymerase lambda	Homo sapiens	125-146
16483311-3	2006	The inhibitory effect on pol lambda (full-length, i.e. intact pol lambda including the BRCA1 C- terminal [BRCT] domain) by some derivatives was stronger than that by curcumin, and monoacetylcurcumin (compound 13) was the strongest pol lambda inhibitor of all the compounds tested, achieving 50% inhibition at a concentration of 3.9 microm.	Curcumin	166-174	BRCA1 DNA repair associated	Homo sapiens	87-92
16951739-0	2006	Curcumin induces cell death without oligonucleosomal DNA fragmentation in quiescent and proliferating human CD8+ cells.	Curcumin	0-8	CD8a molecule	Homo sapiens	108-111
16951739-2	2006	The purpose of this study was to elucidate the propensity of quiescent and proliferating human CD8+ cells to undergo cell death upon treatment with curcumin, a natural dye in Phase I of clinical trials as a prospective chemopreventive agent.	Curcumin	148-156	CD8a molecule	Homo sapiens	95-98
26417261-7	2014	Interestingly, curcumin exhibited high efficiency of antimalarial activity (IC50 ~10 microM) and decreased bEnd.3 apoptosis down to 60.0 % and 79.6 % upon pre-treatment and co-treatment, respectively, with Pf-IRBC, platelets and PBMC.	Curcumin	15-23	BEN domain containing 3	Mus musculus	107-113
23730211-8	2013	Therefore, using different markers of senescence [senescence-associated beta-galactosidase (SA-beta-gal) activity, Ki-67 and Lamin B1 levels, and bromodeoxyuridine incorporation], we have shown that curcumin markedly suppresses Lamin B1 and triggers DNA damage-independent senescence in proliferating but not quiescent breast stromal fibroblasts.	Curcumin	199-207	lamin B1	Homo sapiens	125-133
16951739-3	2006	METHODS: We treated human quiescent or proliferating CD8+ cells with 50 microM curcumin or irradiated them with UVC.	Curcumin	79-87	CD8a molecule	Homo sapiens	53-56
23730211-8	2013	Therefore, using different markers of senescence [senescence-associated beta-galactosidase (SA-beta-gal) activity, Ki-67 and Lamin B1 levels, and bromodeoxyuridine incorporation], we have shown that curcumin markedly suppresses Lamin B1 and triggers DNA damage-independent senescence in proliferating but not quiescent breast stromal fibroblasts.	Curcumin	199-207	lamin B1	Homo sapiens	228-236
24790981-6	2014	More importantly, we show that histone acetyltransferase (HAT) activity is important for GATA4 gene expression with the use of curcumin, a HAT inhibitor.	Curcumin	127-135	GATA binding protein 4	Homo sapiens	89-94
23563640-8	2013	The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P&lt;0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P&lt;0.01, respectively).	Curcumin	93-101	sonic hedgehog signaling molecule	Homo sapiens	265-268
24603592-0	2014	Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model.	Curcumin	0-8	CREB binding protein	Rattus norvegicus	56-59
16507510-7	2006	Caffeic acid, ferulic acid, gallic acid and EGCG inhibited NAT1 but not NAT2, whereas scopuletin and curcumin inhibited NAT2 but not NAT1.	Curcumin	101-109	N-acetyltransferase 2	Homo sapiens	120-124
24603592-0	2014	Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model.	Curcumin	0-8	brain-derived neurotrophic factor	Rattus norvegicus	119-123
16507510-9	2006	The kinetics of inhibition of NAT1 by caffeic acid, EGCG and quercetin were of the non-competitive type, whereas that of NAT2 by quercetin, curcumin and kaemferol was also of the non-competitive type.	Curcumin	140-148	N-acetyltransferase 2	Homo sapiens	121-125
24603592-3	2014	Curcumin has long been recognized as a p300/CREB-binding protein (CBP) inhibitor of histone acetyltransferase (HAT) activity.	Curcumin	0-8	CREB binding protein	Rattus norvegicus	39-64
23563640-8	2013	The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P&lt;0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P&lt;0.01, respectively).	Curcumin	93-101	vimentin	Homo sapiens	279-287
24603592-3	2014	Curcumin has long been recognized as a p300/CREB-binding protein (CBP) inhibitor of histone acetyltransferase (HAT) activity.	Curcumin	0-8	CREB binding protein	Rattus norvegicus	66-69
23563640-8	2013	The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P&lt;0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P&lt;0.01, respectively).	Curcumin	93-101	sonic hedgehog signaling molecule	Homo sapiens	265-268
24603592-6	2014	Furthermore, with this model we investigated the effect of curcumin on P300/CBP HAT activity-regulated release of the pro-nociceptive molecules, brain-derived neurotrophic factor (BDNF) and cyclooxygenase-2 (Cox-2).	Curcumin	59-67	CREB binding protein	Rattus norvegicus	76-79
24603592-8	2014	Chromatin immunoprecipitation analysis revealed that curcumin dose-dependently reduced the recruitment of p300/CBP and acetyl-Histone H3/acetyl-Histone H4 to the promoter of BDNF and Cox-2 genes.	Curcumin	53-61	CREB binding protein	Rattus norvegicus	111-114
16391419-3	2005	We hypothesized that curcumin could inhibit the development of atherosclerosis in the apoE/LDLR-double knockout mice fed with Western diet (21% fat, 0.15% cholesterol w/w, without cholic acid).	Curcumin	21-29	low density lipoprotein receptor	Mus musculus	91-95
24603592-8	2014	Chromatin immunoprecipitation analysis revealed that curcumin dose-dependently reduced the recruitment of p300/CBP and acetyl-Histone H3/acetyl-Histone H4 to the promoter of BDNF and Cox-2 genes.	Curcumin	53-61	brain-derived neurotrophic factor	Rattus norvegicus	174-178
23563640-8	2013	The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P&lt;0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P&lt;0.01, respectively).	Curcumin	93-101	vimentin	Homo sapiens	279-287
24603592-9	2014	A similar dose-dependent decrease of BDNF and Cox-2 in the spinal cord was also observed after curcumin treatment.	Curcumin	95-103	brain-derived neurotrophic factor	Rattus norvegicus	37-41
24603592-10	2014	These results indicated that curcumin exerted a therapeutic role in neuropathic pain by down-regulating p300/CBP HAT activity-mediated gene expression of BDNF and Cox-2.	Curcumin	29-37	CREB binding protein	Rattus norvegicus	109-112
16391419-7	2005	To our knowledge, this is the first report that shows the anti-atherogenic effect of low dose of curcumin in fine model of atherosclerosis: gene-targeted apoE/LDLR-double knockout mice.	Curcumin	97-105	low density lipoprotein receptor	Mus musculus	159-163
16358608-10	2005	Curcumin (AP-1 inhibitor) markedly suppressed the TNF-alpha-induced CCL2 expression.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	10-14
24603592-10	2014	These results indicated that curcumin exerted a therapeutic role in neuropathic pain by down-regulating p300/CBP HAT activity-mediated gene expression of BDNF and Cox-2.	Curcumin	29-37	brain-derived neurotrophic factor	Rattus norvegicus	154-158
24216994-7	2013	Conditioned media from PC3 cells treated with curcumin or MEK inhibitor inhibited tube formation in vitro in human microvascular endothelial cells.	Curcumin	46-54	proprotein convertase subtilisin/kexin type 1	Homo sapiens	23-26
16309195-10	2005	ROS generation by curcumin was suppressed by antioxidants such as N-acetyl-L-cysteine (NAC) and glutathione (GSH) and by scavengers of hydroxy radicals such as mannitol, but, conversely, was promoted by prooxidants such as the transition metal ions Cu(II) and Zn(II).	Curcumin	18-26	X-linked Kx blood group	Homo sapiens	87-90
23466486-3	2013	In this study, we have shown that curcumin can suppress epidermal growth factor (EGF)- stimulated and heregulin-stimulated PC-3 cell invasion, as well as androgen-induced LNCaP cell invasion.	Curcumin	34-42	epidermal growth factor	Homo sapiens	56-79
16221204-0	2005	Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis through up-regulation of heme oxygenase 1.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	83-99
16221204-2	2005	Curcumin, a polyphenolic compound, has antifibrotic effects in lung models of fibrosis, and is known to induce HO-1 in renal tubular cells.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	111-115
16221204-4	2005	METHODS: Curcumin effects on HO-1 expression in cultured mesangial cells and in glomeruli in vivo were analyzed by Northern and Western blotting.	Curcumin	9-17	heme oxygenase 1	Rattus norvegicus	29-33
16221204-9	2005	RESULTS: Curcumin potently induced mesangial cell HO-1 expression in vitro and up-regulated glomerular HO-1 expression in nephritic animals in vivo.	Curcumin	9-17	heme oxygenase 1	Rattus norvegicus	50-54
24487968-0	2014	Curcumin derivative C817 inhibits proliferation of imatinib-resistant chronic myeloid leukemia cells with wild-type or mutant Bcr-Abl in vitro.	Curcumin	0-8	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	126-133
24431405-5	2014	Using in vitro models with mouse and human malignant mesothelioma cells, curcumin is shown to induce pyroptosis through activation of caspase-1 and increased release of high-mobility group box 1 (HMGB1) without processing of IL-1beta and IL-18.	Curcumin	73-81	interleukin 18	Homo sapiens	238-243
24648190-1	2014	The purpose of this work was to synthesize a series of symmetrical analogs (CA2-CA7) of curcumin and determine their efficacy as antioxidant and anticancer agents in vitro.	Curcumin	88-96	carbonic anhydrase 2	Homo sapiens	76-83
24648190-4	2014	Two analogs, CA2 and CA3, had lower potencies as anticancer agents compared with curcumin, while CA6 had a slightly higher IC50 value.	Curcumin	81-89	carbonic anhydrase 2	Homo sapiens	13-16
16221204-9	2005	RESULTS: Curcumin potently induced mesangial cell HO-1 expression in vitro and up-regulated glomerular HO-1 expression in nephritic animals in vivo.	Curcumin	9-17	heme oxygenase 1	Rattus norvegicus	103-107
16221204-11	2005	Beneficial effects of curcumin on markers of fibrosis and proteinuria were lost after HO-1 inhibition.	Curcumin	22-30	heme oxygenase 1	Rattus norvegicus	86-90
16221204-12	2005	CONCLUSION: Curcumin has antifibrotic effects in glomerular disease, which are mediated through an induction of HO-1.	Curcumin	12-20	heme oxygenase 1	Rattus norvegicus	112-116
16102725-0	2005	Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	42-68
16102725-2	2005	This study has investigated the effects of curcumin on MMP-9 expression in human astroglioma cell lines.	Curcumin	43-51	matrix metallopeptidase 9	Homo sapiens	55-60
16102725-3	2005	Curcumin significantly inhibited the MMP-9 enzymatic activity and protein expression that was induced by PMA.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	37-42
23466486-3	2013	In this study, we have shown that curcumin can suppress epidermal growth factor (EGF)- stimulated and heregulin-stimulated PC-3 cell invasion, as well as androgen-induced LNCaP cell invasion.	Curcumin	34-42	epidermal growth factor	Homo sapiens	81-84
16102725-4	2005	The inhibitory effect of curcumin on MMP-9 expression correlates with the decreased MMP-9 mRNA level and the suppression of MMP-9 promoter activity.	Curcumin	25-33	matrix metallopeptidase 9	Homo sapiens	37-42
23466486-5	2013	Our data further show that curcumin is able to inhibit the induction effects of androgens and EGF on matriptase activation, as well as to reduce the activated levels of matriptase after its overexpression, thus suggesting that curcumin may interrupt diverse signal pathways to block the protease.	Curcumin	27-35	epidermal growth factor	Homo sapiens	94-97
16102725-4	2005	The inhibitory effect of curcumin on MMP-9 expression correlates with the decreased MMP-9 mRNA level and the suppression of MMP-9 promoter activity.	Curcumin	25-33	matrix metallopeptidase 9	Homo sapiens	84-89
24634837-4	2014	Compared to non-supplemented control mice, we observed a significant reduction in iron, but not zinc and copper stores, in the liver and the spleen, as well as strongly suppressed liver hepcidin and ferritin expression in the curcumin-supplemented mice.	Curcumin	226-234	hepcidin antimicrobial peptide	Mus musculus	186-194
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	15-23	DNA-damage inducible transcript 3	Mus musculus	201-225
16193380-6	2005	Alteration of NF-kappaB activity in NP-2 human malignant astrocytoma cell line after treatment with curcumin was examined using electrophoretic mobility shift assay.	Curcumin	100-108	neuropilin 2	Homo sapiens	36-40
16193380-8	2005	Induction of apoptosis by curcumin in NP-2 and NP-3 human malignant astrocytoma cell lines was examined by DNA-fragmentation analysis and morphological observation.	Curcumin	26-34	neuropilin 2	Homo sapiens	38-42
16193380-8	2005	Induction of apoptosis by curcumin in NP-2 and NP-3 human malignant astrocytoma cell lines was examined by DNA-fragmentation analysis and morphological observation.	Curcumin	26-34	leukemia NUP98 fusion partner 1	Homo sapiens	47-51
16193380-9	2005	We found that the NF-kappaB activity in NP-2 was significantly reduced by curcumin.	Curcumin	74-82	neuropilin 2	Homo sapiens	40-44
24570592-0	2014	Synergism from the combination of ulinastatin and curcumin offers greater inhibition against colorectal cancer liver metastases via modulating matrix metalloproteinase-9 and E-cadherin expression.	Curcumin	50-58	matrix metallopeptidase 9	Homo sapiens	143-169
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	15-23	DNA-damage inducible transcript 3	Mus musculus	227-231
24570592-2	2014	The current study was to investigate the ability of ulinastatin (UTI) and curcumin (CUR) to inhibit CRC liver metastases via modulating matrix metalloproteinase-9 (MMP-9) and E-cadherin expression.	Curcumin	74-82	matrix metallopeptidase 9	Homo sapiens	136-162
24570592-2	2014	The current study was to investigate the ability of ulinastatin (UTI) and curcumin (CUR) to inhibit CRC liver metastases via modulating matrix metalloproteinase-9 (MMP-9) and E-cadherin expression.	Curcumin	74-82	matrix metallopeptidase 9	Homo sapiens	164-169
16193380-11	2005	Nuclear condensation and fragmentation, and DNA fragmentation were observed in both NP-2 and NP-3 after the treatment with curcumin.	Curcumin	123-131	neuropilin 2	Homo sapiens	84-88
16193380-11	2005	Nuclear condensation and fragmentation, and DNA fragmentation were observed in both NP-2 and NP-3 after the treatment with curcumin.	Curcumin	123-131	leukemia NUP98 fusion partner 1	Homo sapiens	93-97
16083495-1	2005	BACKGROUND: Inhibition of the COP9 signalosome (CSN) associated kinases CK2 and PKD by curcumin causes stabilization of the tumor suppressor p53.	Curcumin	87-95	protein kinase D1	Homo sapiens	80-83
16083495-3	2005	Curcumin and emodin block the CSN-directed c-Jun signaling pathway, which results in diminished c-Jun steady state levels in HeLa cells.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	43-48
16083495-3	2005	Curcumin and emodin block the CSN-directed c-Jun signaling pathway, which results in diminished c-Jun steady state levels in HeLa cells.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	96-101
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	15-23	endoplasmic reticulum (ER) to nucleus signalling 2	Mus musculus	277-304
16036795-7	2005	Up-regulation of COX-2 and the above ER signaling factors was reversed by treatment of the infected cells with curcumin which specifically inhibits the JNK/c-Jun pathway.	Curcumin	111-119	mitogen-activated protein kinase 8	Mus musculus	152-155
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	15-23	endoplasmic reticulum (ER) to nucleus signalling 2	Mus musculus	306-310
15256484-6	2004	Curcumin treatment also induced JNK-dependent sustained phosphorylation of c-jun and stimulation of AP-1 transcriptional activity.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-80
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	100-108	DNA-damage inducible transcript 3	Mus musculus	201-225
15256484-7	2004	Curcumin-mediated c-jun phosphorylation and apoptosis were reduced by treatment with the JNK-specific inhibitor SP600125.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-23
21793155-7	2013	Interestingly, curcumin enhanced the level of the antiapoptotic protein Bcl-2 which might show that curcumin-induced apoptosis is done through the ER stress signaling pathways based on the increase of CIEBP homologous protein (CHOP), activating transcription factor 6 (ATF-6), inositol-requiring enzyme 1 (IRE1), and caspase-12 in WEHI-3 cells.	Curcumin	100-108	DNA-damage inducible transcript 3	Mus musculus	227-231
24476477-9	2014	Present results suggest a therapeutic potential of curcumin to decrease oxidation caused by obesity in humans and also show that curcumin restores BDNF levels in DM.	Curcumin	129-137	brain derived neurotrophic factor	Homo sapiens	147-151
22898567-7	2013	We also demonstrate that curcumin significantly suppressed the increased expression of transforming growth factor beta, vascular endothelial growth factor and extracellular matrix proteins such as type IV collagen and fibronectin.	Curcumin	25-33	fibronectin 1	Rattus norvegicus	218-229
24531649-15	2014	Dendrosomal curcumin significantly decreased the relative expression of OCT4A, OCT4B1, SOX-2, and Nanog along with noticeable overexpression of miR-145 as the upstream regulator.	Curcumin	12-20	SRY-box transcription factor 2	Homo sapiens	87-92
22898567-8	2013	In addition, curcumin treatment increased nephrin expression to near-normal levels in diabetic rats.	Curcumin	13-21	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	42-49
24531649-15	2014	Dendrosomal curcumin significantly decreased the relative expression of OCT4A, OCT4B1, SOX-2, and Nanog along with noticeable overexpression of miR-145 as the upstream regulator.	Curcumin	12-20	Nanog homeobox	Homo sapiens	98-103
24531649-16	2014	This suggests that dendrosomal curcumin reduces the proliferation of U87MG cells through the downregulation of OCT4 (octamer binding protein 4) variants and SOX-2 (SRY [sex determining region Y]-box 2) in an miR-145-dependent manner.	Curcumin	31-39	SRY-box transcription factor 2	Homo sapiens	157-162
15280357-0	2004	Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.	Curcumin	79-87	cystic fibrosis transmembrane conductance regulator	Mus musculus	51-55
23944054-0	2013	[Effect of curcumin on hippocampal IRS-1 and p-IRS-1 expressions in APP/PS1 double transgenic mice].	Curcumin	11-19	insulin receptor substrate 1	Mus musculus	47-52
15073046-0	2004	Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase.	Curcumin	45-53	phospholipase A2 group IVA	Homo sapiens	104-168
15073046-5	2004	Inhibition of phosphorylation of cPLA(2), the activation process of this enzyme, rather than direct inhibition of cPLA(2) activity appears to be involved in the effect of curcumin.	Curcumin	171-179	phospholipase A2 group IVA	Homo sapiens	33-40
15073046-11	2004	The results suggest that curcumin affects arachidonic acid metabolism by blocking the phosphorylation of cPLA(2), decreasing the expression of COX-2 and inhibiting the catalytic activities of 5-LOX.	Curcumin	25-33	phospholipase A2 group IVA	Homo sapiens	105-112
24275249-8	2014	Using transwell assays, we also found that these compounds were more potent than 1a (curcumin) in impeding the invasion of osteosarcoma cells, possibly through suppressing MMP-9 activity.	Curcumin	85-93	matrix metallopeptidase 9	Homo sapiens	172-177
23944054-1	2013	OBJECTIVE: To observe the effect of curcumin on the expressions of insulin receptor substrate-1 (IRS-1) and phosphated insulin receptor substrate-1 (p-IRS-1I) in APP/PS1 double transgenic mice of the AD model.	Curcumin	36-44	insulin receptor substrate 1	Mus musculus	67-95
23944054-1	2013	OBJECTIVE: To observe the effect of curcumin on the expressions of insulin receptor substrate-1 (IRS-1) and phosphated insulin receptor substrate-1 (p-IRS-1I) in APP/PS1 double transgenic mice of the AD model.	Curcumin	36-44	insulin receptor substrate 1	Mus musculus	97-102
23911971-7	2014	The combination of curcumin and DHA was also efficient in counteracting reductions in the plasticity markers, brain-derived neurotrophic factor and its receptor p-trkB, and learning ability, which had been lessened after TBI.	Curcumin	19-27	brain-derived neurotrophic factor	Rattus norvegicus	110-143
15358181-0	2004	Synthetic curcumin analogs inhibit activator protein-1 transcription and tumor-induced angiogenesis.	Curcumin	10-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-54
23944054-1	2013	OBJECTIVE: To observe the effect of curcumin on the expressions of insulin receptor substrate-1 (IRS-1) and phosphated insulin receptor substrate-1 (p-IRS-1I) in APP/PS1 double transgenic mice of the AD model.	Curcumin	36-44	insulin receptor substrate 1	Mus musculus	119-147
24349037-14	2013	Western Blot analyses revealed that of these targets anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and proliferating cell nuclear antigen (PCNA) were significantly down-regulated in curcumin-treated tumors.	Curcumin	181-189	proliferating cell nuclear antigen	Mus musculus	102-136
24349037-14	2013	Western Blot analyses revealed that of these targets anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and proliferating cell nuclear antigen (PCNA) were significantly down-regulated in curcumin-treated tumors.	Curcumin	181-189	proliferating cell nuclear antigen	Mus musculus	138-142
15126503-6	2004	Depleting Jab1/CSN5 by antisense oligonucleotide and treating cells with the CSN-associated kinase inhibitor, curcumin, inhibited topo IIalpha degradation induced by glucose starvation.	Curcumin	110-118	COP9 signalosome subunit 5	Homo sapiens	10-14
23944054-1	2013	OBJECTIVE: To observe the effect of curcumin on the expressions of insulin receptor substrate-1 (IRS-1) and phosphated insulin receptor substrate-1 (p-IRS-1I) in APP/PS1 double transgenic mice of the AD model.	Curcumin	36-44	presenilin 1	Mus musculus	166-169
15126503-6	2004	Depleting Jab1/CSN5 by antisense oligonucleotide and treating cells with the CSN-associated kinase inhibitor, curcumin, inhibited topo IIalpha degradation induced by glucose starvation.	Curcumin	110-118	COP9 signalosome subunit 5	Homo sapiens	15-19
15356994-5	2004	Subsequently, curcumin inhibits the activation of NF(nucleor factor)kappaB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs and iNOS.	Curcumin	14-22	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	118-123
23944054-15	2013	01) and the number of p-IRS-1 positive cells in hippocampus CA1 area increased in all of curcumin intervention groups.	Curcumin	89-97	insulin receptor substrate 1	Mus musculus	24-29
15356994-5	2004	Subsequently, curcumin inhibits the activation of NF(nucleor factor)kappaB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs and iNOS.	Curcumin	14-22	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	125-130
23944054-15	2013	01) and the number of p-IRS-1 positive cells in hippocampus CA1 area increased in all of curcumin intervention groups.	Curcumin	89-97	carbonic anhydrase 1	Mus musculus	60-63
23632743-6	2013	Quantitative real-time RT-PCR analysis showed that curcumin substantially inhibited both AdBMP2-induced and basal expression levels of cardiac transcription factors GATA4 and MEF2C, but not Tbx5.	Curcumin	51-59	myocyte enhancer factor 2C	Rattus norvegicus	175-180
15142674-9	2004	Bak and Caspase genes remained unchanged up to 60 microM curcumin but showed decrease in expression levels at 80-160 microM.	Curcumin	57-65	BCL2 antagonist/killer 1	Homo sapiens	0-3
23944054-18	2013	CONCLUSION: Curcumin can recover increased IRS-1 and decreased p-IRS-1 in hippocampus of APP/PS1 double transgenic mice, increase IRS-1 mRNA expression, and improve the insulin-signaling transduction in APP/PS1 double transgenic mice.	Curcumin	12-20	insulin receptor substrate 1	Mus musculus	43-48
23632743-7	2013	Similarly, chromatin immunoprecipitation (ChIP) analysis showed that curcumin inhibited both AdBMP2-induced and basal histone H3 acetylation levels in the promoter regions of GATA4 and MEF2C, but not of Tbx5.	Curcumin	69-77	myocyte enhancer factor 2C	Rattus norvegicus	185-190
23944054-18	2013	CONCLUSION: Curcumin can recover increased IRS-1 and decreased p-IRS-1 in hippocampus of APP/PS1 double transgenic mice, increase IRS-1 mRNA expression, and improve the insulin-signaling transduction in APP/PS1 double transgenic mice.	Curcumin	12-20	insulin receptor substrate 1	Mus musculus	65-70
24064724-4	2013	Our results from molecular simulation of curcumin binding to Dvl2 protein and from binding free energy calculations suggest that curcumin may prevent axin recruitment to cellular membrane in order to maintain the functional beta-catenin destruction complex in normal cells.	Curcumin	41-49	dishevelled segment polarity protein 2	Homo sapiens	61-65
24064724-4	2013	Our results from molecular simulation of curcumin binding to Dvl2 protein and from binding free energy calculations suggest that curcumin may prevent axin recruitment to cellular membrane in order to maintain the functional beta-catenin destruction complex in normal cells.	Curcumin	129-137	dishevelled segment polarity protein 2	Homo sapiens	61-65
23944054-18	2013	CONCLUSION: Curcumin can recover increased IRS-1 and decreased p-IRS-1 in hippocampus of APP/PS1 double transgenic mice, increase IRS-1 mRNA expression, and improve the insulin-signaling transduction in APP/PS1 double transgenic mice.	Curcumin	12-20	presenilin 1	Mus musculus	93-96
24064724-4	2013	Our results from molecular simulation of curcumin binding to Dvl2 protein and from binding free energy calculations suggest that curcumin may prevent axin recruitment to cellular membrane in order to maintain the functional beta-catenin destruction complex in normal cells.	Curcumin	129-137	axin 1	Homo sapiens	150-154
15100369-12	2004	As compared with MCP-1, MIP-2 mRNA expression was inhibited by a high dose of curcumin but not by NF-kappaB decoy oligodeoxynucleotide and individual inhibitions of MAP kinase, suggesting that the additional signaling pathway with NF-kappaB might be involved in mRNA expression of MIP-2.	Curcumin	78-86	chemokine (C-C motif) ligand 2	Mus musculus	17-22
23944054-18	2013	CONCLUSION: Curcumin can recover increased IRS-1 and decreased p-IRS-1 in hippocampus of APP/PS1 double transgenic mice, increase IRS-1 mRNA expression, and improve the insulin-signaling transduction in APP/PS1 double transgenic mice.	Curcumin	12-20	insulin receptor substrate 1	Mus musculus	65-70
23794119-13	2013	Curcumin effect was mediated through activation of TNFR, CASP 8, CASP3, BID, BAX, and down-regulation of NFkappaB, NDRG 1, and BCL2L10 genes.	Curcumin	0-8	N-myc downstream regulated 1	Homo sapiens	115-121
23944054-18	2013	CONCLUSION: Curcumin can recover increased IRS-1 and decreased p-IRS-1 in hippocampus of APP/PS1 double transgenic mice, increase IRS-1 mRNA expression, and improve the insulin-signaling transduction in APP/PS1 double transgenic mice.	Curcumin	12-20	presenilin 1	Mus musculus	207-210
23566056-6	2013	Curcumin treatment was associated with amelioration of macroscopic and microscopic colitis sores, decreased MPO activity, and decreased MDA levels in acetic acid-induced colitis.	Curcumin	0-8	myeloperoxidase	Rattus norvegicus	108-111
15105504-4	2004	Oral administration of curcumin to homozygous DeltaF508 CFTR mice in doses comparable, on a weight-per-weight basis, to those well tolerated by humans corrected these animals" characteristic nasal potential difference defect.	Curcumin	23-31	cystic fibrosis transmembrane conductance regulator	Mus musculus	56-60
23566056-8	2013	The results of this study suggest that oral curcumin treatment decreases colon injury and is associated with decreased inflammatory reactions, lipid peroxidation, apoptotic cell death, and modulating p38- and JNK-MAPK pathways.	Curcumin	44-52	mitogen-activated protein kinase 8	Rattus norvegicus	209-212
23359272-0	2013	The curcumin analog DM-1 induces apoptotic cell death in melanoma.	Curcumin	4-12	immunoglobulin heavy diversity 1-7	Homo sapiens	20-24
15160995-4	2004	The cytotoxicity of, and ROS generation by, curcumin were reduced by the addition of N-acetyl-L-cysteine (NAC) and glutathione, suggesting a possible link between cytotoxicity and ROS.	Curcumin	44-52	X-linked Kx blood group	Homo sapiens	106-109
24098980-0	2013	Anti-cancer activity of anti-GLUT1 antibody-targeted polymeric micelles co-loaded with curcumin and doxorubicin.	Curcumin	87-95	solute carrier family 2 member 1	Homo sapiens	29-34
24369238-6	2013	Curcumin inhibited the invasion and migration of HeLa cells by increasing E-cad expression and decreasing MMP-9 expression, and also decreased the expression level of iNOS and NO production in the cells.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	106-111
24369247-5	2013	Treatment of Jurkat cells with 25, 50, and 75 micromol/L curcumin resulted in a concentration-dependent increase of JNK and p-JNK expressions (P&lt;0.01) without significantly affecting the expressions of ERK1/2 and P38 MAPK or the activity of MMP-2 and MMP-9.	Curcumin	57-65	matrix metallopeptidase 9	Homo sapiens	254-259
15022320-13	2004	PD 98059, fludarabine, piceatannol, and curcumin (AP-1 inhibitor) inhibited the OSM-induced expression of CCL2.	Curcumin	40-48	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-54
23359272-3	2013	The DM-1 compound is a curcumin analog that possesses several curcumin characteristics, such as antiproliferative, antitumor, and antimetastatic properties.	Curcumin	23-31	immunoglobulin heavy diversity 1-7	Homo sapiens	4-8
23359272-3	2013	The DM-1 compound is a curcumin analog that possesses several curcumin characteristics, such as antiproliferative, antitumor, and antimetastatic properties.	Curcumin	62-70	immunoglobulin heavy diversity 1-7	Homo sapiens	4-8
14715692-5	2004	We report that the activity of a genomic-integrated 2.2 kb MMP-9 promoter sequence mirrors expression of the endogenous MMP-9 gene in response to both physiological and pharmacological (curcumin) cues.	Curcumin	186-194	matrix metallopeptidase 9	Homo sapiens	59-64
23352975-0	2013	Curcumin induces FasL-related apoptosis through p38 activation in human hepatocellular carcinoma Huh7 cells.	Curcumin	0-8	Fas ligand	Homo sapiens	17-21
14715692-5	2004	We report that the activity of a genomic-integrated 2.2 kb MMP-9 promoter sequence mirrors expression of the endogenous MMP-9 gene in response to both physiological and pharmacological (curcumin) cues.	Curcumin	186-194	matrix metallopeptidase 9	Homo sapiens	120-125
14634121-6	2003	Curcumin consistently suppressed not only NF binding to IFN-gamma-activated sequence/IFN-stimulated regulatory element, but also the expression of inflammation-associated genes, including ICAM-1 and monocyte chemoattractant protein 1, whose promoters contain STAT-binding elements.	Curcumin	0-8	intercellular adhesion molecule 1	Rattus norvegicus	188-194
24134851-8	2013	Curcumin-mediated attenuation of Abeta-induced synaptic dysfunction involved regulation of synaptic proteins, namely phospho-CaMKII and phospho-synapsin I.	Curcumin	0-8	synapsin I	Homo sapiens	144-154
23954730-0	2013	Free and nanoencapsulated curcumin suppress beta-amyloid-induced cognitive impairments in rats: involvement of BDNF and Akt/GSK-3beta signaling pathway.	Curcumin	26-34	brain-derived neurotrophic factor	Rattus norvegicus	111-115
23352975-5	2013	KEY FINDINGS: Curcumin treatment resulted in a fast and significant increase of Fas and Fas ligand (FasL) along with activation of caspase-3 and cleavage of PARP in Huh7 cells.	Curcumin	14-22	Fas ligand	Homo sapiens	88-98
23352975-5	2013	KEY FINDINGS: Curcumin treatment resulted in a fast and significant increase of Fas and Fas ligand (FasL) along with activation of caspase-3 and cleavage of PARP in Huh7 cells.	Curcumin	14-22	Fas ligand	Homo sapiens	100-104
24236240-8	2013	This study suggests that the probable mechanism of action of curcumin is via the reduction of p300 HAT activity.	Curcumin	61-69	E1A binding protein p300	Mus musculus	94-98
23352975-7	2013	Neutralization of FasL significantly protected the cells from curcumin-induced caspase-3 activation and apoptosis in a dose-dependent manner.	Curcumin	62-70	Fas ligand	Homo sapiens	18-22
12869420-9	2003	alpha-Angelicalactone, coumarin and curcumin showed enhanced UGT enzyme activities at all five sites.	Curcumin	36-44	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	61-64
23175174-6	2013	BAY117085 and different concentrations of curcumin were applied to the cells just after the first experiment to determine their concentration effect on ADAMTS9 gene expression.	Curcumin	42-50	ADAM metallopeptidase with thrombospondin type 1 motif 9	Homo sapiens	152-159
12869420-10	2003	Both small and large intestinal UGT enzyme activities were increased by quercetin, alpha-angelicalactone, coumarin, curcumin and flavone.	Curcumin	116-124	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	32-35
23352975-8	2013	Moreover, p38 was rapidly activated in response to curcumin, and inactivation of p38 by pharmacologic inhibitor SB203580 dramatically suppressed curcumin-induced FasL expression and apoptosis.	Curcumin	51-59	Fas ligand	Homo sapiens	162-166
14500688-4	2003	Curcumin had no effect on STAT5 phosphorylation, but inhibited the IFN-alpha-induced STAT1 phosphorylation.	Curcumin	0-8	signal transducer and activator of transcription 1	Homo sapiens	85-90
23352975-8	2013	Moreover, p38 was rapidly activated in response to curcumin, and inactivation of p38 by pharmacologic inhibitor SB203580 dramatically suppressed curcumin-induced FasL expression and apoptosis.	Curcumin	145-153	Fas ligand	Homo sapiens	162-166
12853969-7	2003	TGF-beta1 activated c-Jun phosphorylation, and IL-6 induction by TGF-beta1 was severely impeded by DN-c-Jun and DN-JNK or AP-1 inhibitor curcumin, showing that the JNK-c-Jun-AP-1 signaling plays a pivotal role in TGF-beta1 stimulation of IL-6.	Curcumin	137-145	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	122-126
23352975-9	2013	SIGNIFICANCE: Our results demonstrated that curcumin induces apoptosis through p38-denpendent up-regulation of FasL in Huh7 cells.	Curcumin	44-52	Fas ligand	Homo sapiens	111-115
12807725-0	2003	Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.	Curcumin	10-27	matrix metallopeptidase 9	Homo sapiens	202-207
23325107-0	2013	Curcumin ameliorates the neurodegenerative pathology in A53T alpha-synuclein cell model of Parkinson"s disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.	Curcumin	0-8	synuclein alpha	Homo sapiens	61-76
12818219-6	2003	Addition of curcumin (an inhibitor of nuclear transcription for the inflammatory cascade) abrogated expression of adhesion molecules at a statistically significant level for ICAM-1 in 8/10 PVE, and for E-selectin in all 10 PVE.	Curcumin	12-20	intercellular adhesion molecule 1	Homo sapiens	174-180
23933360-6	2013	In conclusion, these results confirm that the Zn(II)-curcumin complex possesses an enhanced mucosal barrier defense activity compared to curcumin alone, due to its synergistic ability to decrease oxidative stress and attenuate MMP-9-mediated inflammation.	Curcumin	53-61	matrix metallopeptidase 9	Rattus norvegicus	227-232
23816368-1	2013	OBJECTIVE: Accumulating evidence indicates that curcumin potently protects against beta-amyloid (Abeta) due to its oxygen free radicals scavenging and anti-inflammatory properties.	Curcumin	48-56	amyloid beta precursor protein	Rattus norvegicus	83-103
23328441-7	2013	Furthermore, curcumin decreased expression of receptor interacting protein 1 in a dose- and time-dependent manner.	Curcumin	13-21	receptor interacting serine/threonine kinase 1	Homo sapiens	46-76
23816368-2	2013	However, cellular mechanisms that may underlie the neuroprotective effect of curcumin in Abeta-induced toxicity are not fully understood yet.	Curcumin	77-85	amyloid beta precursor protein	Rattus norvegicus	89-94
23816368-6	2013	RESULTS: Curcumin significantly attenuated Abeta-induced cell death, loss of synaptophysin, and ROS generation.	Curcumin	9-17	amyloid beta precursor protein	Rattus norvegicus	43-48
23816368-6	2013	RESULTS: Curcumin significantly attenuated Abeta-induced cell death, loss of synaptophysin, and ROS generation.	Curcumin	9-17	synaptophysin	Rattus norvegicus	77-90
23816368-8	2013	The phosphorylation of beta-catenin was avoided and the levels of free beta-catenin were increased by curcumin to promote cell survival upon treatment with Abeta.	Curcumin	102-110	amyloid beta precursor protein	Rattus norvegicus	156-161
23816368-9	2013	Curcumin, in the presence of Abeta, activated Akt which in turn phosphorylates GSK-3beta, and resulted in the inhibition of GSK-3beta.	Curcumin	0-8	amyloid beta precursor protein	Rattus norvegicus	29-34
12527553-11	2003	Interestingly, pretreatment with hemin as well as curcumin (inducers of HO-1) inhibited the ANG II-induced tubular cell apoptosis; conversely, pretreatment with zinc protoporphyrin, an inhibitor of HO-1 expression, promoted the effect of ANG II.	Curcumin	50-58	heme oxygenase 1	Rattus norvegicus	72-76
12527553-11	2003	Interestingly, pretreatment with hemin as well as curcumin (inducers of HO-1) inhibited the ANG II-induced tubular cell apoptosis; conversely, pretreatment with zinc protoporphyrin, an inhibitor of HO-1 expression, promoted the effect of ANG II.	Curcumin	50-58	heme oxygenase 1	Rattus norvegicus	198-202
12929584-0	2003	Curcumin decreases the DNA adduct formation, arylamines N-acetyltransferase activity and gene expression in human colon tumor cells (colo 205).	Curcumin	0-8	bromodomain containing 2	Homo sapiens	56-75
12929584-4	2003	The NAT activity in the human colon tumor cells and cytosols was suppressed by curcumin in a dose-dependent manner.	Curcumin	79-87	bromodomain containing 2	Homo sapiens	4-7
23264626-0	2013	Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice.	Curcumin	0-8	microtubule associated protein tau	Homo sapiens	28-31
12929584-6	2003	The apparent values of Km and Vmax of NAT of human colon tumor cells were also decreased by curcumin in cytosols.	Curcumin	92-100	bromodomain containing 2	Homo sapiens	38-41
23264626-0	2013	Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice.	Curcumin	0-8	microtubule associated protein tau	Homo sapiens	121-124
12806293-9	2003	Treatment of oxidative-stressed cultures with either curcumin, a MAPKKK pathway inhibitor, or PD-098059, a MEK1 inhibitor, blocked loss of neurons via the JNK/c-Jun apoptotic pathway.	Curcumin	53-61	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	159-164
23264626-3	2013	We also examined how these interrelationships changed with an intervention by feeding mice either a control diet or one containing the brain permeable beta-amyloid and Tau aggregate binding molecule curcumin.	Curcumin	199-207	microtubule associated protein tau	Homo sapiens	168-171
12473670-5	2003	We also investigated the mechanism of action of curcumin (diferulolylmethane) on OPN-induced NF kappa B-mediated activation of pro-MMP-2 in B16F10 cells.	Curcumin	48-56	matrix metallopeptidase 2	Mus musculus	131-136
12473670-10	2003	The OPN-induced pro-MMP-2 activation and MT1-MMP expression were also drastically reduced by curcumin.	Curcumin	93-101	matrix metallopeptidase 2	Mus musculus	20-25
23264626-7	2013	Curcumin selectively suppressed levels of soluble Tau dimers, but not of insoluble and monomeric phospho-Tau, while correcting behavioral, synaptic, and HSP deficits.	Curcumin	0-8	microtubule associated protein tau	Homo sapiens	50-53
12473670-10	2003	The OPN-induced pro-MMP-2 activation and MT1-MMP expression were also drastically reduced by curcumin.	Curcumin	93-101	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	41-48
23264626-11	2013	In summary, curcumin reduced soluble Tau and elevated HSPs involved in Tau clearance, showing that even after tangles have formed, Tau-dependent behavioral and synaptic deficits can be corrected.	Curcumin	12-20	microtubule associated protein tau	Homo sapiens	37-40
23264626-11	2013	In summary, curcumin reduced soluble Tau and elevated HSPs involved in Tau clearance, showing that even after tangles have formed, Tau-dependent behavioral and synaptic deficits can be corrected.	Curcumin	12-20	microtubule associated protein tau	Homo sapiens	71-74
12745871-11	2003	Curcumin inhibited human SULT1A3, and the inhibition was studied in five liver specimens with an IC(50) of 4324 +/- 1026 nM.	Curcumin	0-8	sulfotransferase family 1A member 3	Homo sapiens	25-32
23264626-11	2013	In summary, curcumin reduced soluble Tau and elevated HSPs involved in Tau clearance, showing that even after tangles have formed, Tau-dependent behavioral and synaptic deficits can be corrected.	Curcumin	12-20	microtubule associated protein tau	Homo sapiens	71-74
12514113-6	2003	Curcumin exposure increased JunD and c-Jun content in AP-1 complexes and increased JunD while decreasing MafG/MafK in EpRE complexes.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-42
23276449-10	2013	These studies may lead to the discovery of novel curcumin analogs that activate nuclear receptors, including RXR, RAR and VDR, resulting in similar health benefits as those for vitamins A and D, such as lowering the risk of epithelial and colon cancers.	Curcumin	49-57	retinoic acid receptor alpha	Homo sapiens	114-117
12631113-14	2003	In contrast, curcumin, an activating protein (AP)-1 inhibitor, attenuated TNF-alpha-stimulated phospho-c-Jun levels and fractalkine expression without discernible effects on TNF-alpha-induced degradation of I-kappaBalpha or NF-kappaB nuclear translocation.	Curcumin	13-21	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-108
12825130-7	2003	A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the IL-17-, IL-1beta-, and TNF-alpha-induced MMP-3 mRNA expression, and mitogen-activated protein (MAP) kinase inhibitors (U0126, PD098059, and SB203580) also blocked MMP-3 secretion.	Curcumin	47-55	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	2-28
12825130-7	2003	A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the IL-17-, IL-1beta-, and TNF-alpha-induced MMP-3 mRNA expression, and mitogen-activated protein (MAP) kinase inhibitors (U0126, PD098059, and SB203580) also blocked MMP-3 secretion.	Curcumin	47-55	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-34
12825130-7	2003	A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the IL-17-, IL-1beta-, and TNF-alpha-induced MMP-3 mRNA expression, and mitogen-activated protein (MAP) kinase inhibitors (U0126, PD098059, and SB203580) also blocked MMP-3 secretion.	Curcumin	47-55	interleukin 17A	Homo sapiens	69-74
12239622-4	2002	Our results show that curcumin down-regulates transactivation and expression of AR, activator protein-1 (AP-1), nuclear factor-kappaB (NF-kappaB), and CREB (cAMP response element-binding protein)-binding protein (CBP).	Curcumin	22-30	cAMP responsive element binding protein 1	Homo sapiens	151-155
22960607-0	2013	NMDA GluN2B receptors involved in the antidepressant effects of curcumin in the forced swim test.	Curcumin	64-72	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	5-11
12408761-2	2002	METHODS: The effect of curcumin on the growth of CA46 cells and apoptosis were studied through Trypan blue exclusion, MTT assay, cell cycle, DNA fragmentation analysis and detection of TdT-mediated dUTP nick end labeling (TUNEL).	Curcumin	23-31	DNA nucleotidylexotransferase	Homo sapiens	185-188
12126654-6	2002	In parallel, curcumin decreased, in a dose-dependent manner, the UVB-mediated overexpression of all three pro-inflammatory cytokines and only exhibited a moderate enhancing influence on IL-10 expression.	Curcumin	13-21	interleukin 10	Homo sapiens	186-191
24312824-0	2013	Comparison of inhibitory effect of curcumin nanoparticles and free curcumin in human telomerase reverse transcriptase gene expression in breast cancer.	Curcumin	35-43	telomerase reverse transcriptase	Homo sapiens	85-117
11676493-5	2001	Probing further into the molecular signals leading to apoptosis of EAC cells, we observed that curcumin is causing tumor cell death by the up-regulation of the proto-oncoprotein Bax, release of cytochrome c from the mitochondria, and activation of caspase-3.	Curcumin	95-103	BCL2-associated X protein	Mus musculus	178-181
11676493-5	2001	Probing further into the molecular signals leading to apoptosis of EAC cells, we observed that curcumin is causing tumor cell death by the up-regulation of the proto-oncoprotein Bax, release of cytochrome c from the mitochondria, and activation of caspase-3.	Curcumin	95-103	caspase 3	Mus musculus	248-257
11322764-11	2001	Instead, curcumin enhanced expression of heat shock protein 70 (HSP70) in HK-2 cells under control conditions and after exposure to Stx1 or Stx2.	Curcumin	9-17	heat shock protein family A (Hsp70) member 4	Homo sapiens	41-62
11322764-11	2001	Instead, curcumin enhanced expression of heat shock protein 70 (HSP70) in HK-2 cells under control conditions and after exposure to Stx1 or Stx2.	Curcumin	9-17	heat shock protein family A (Hsp70) member 4	Homo sapiens	64-69
11322764-11	2001	Instead, curcumin enhanced expression of heat shock protein 70 (HSP70) in HK-2 cells under control conditions and after exposure to Stx1 or Stx2.	Curcumin	9-17	syntaxin 2	Homo sapiens	140-144
11322764-14	2001	The cytoprotective effect of curcumin against Stx-induced injury in cultured human proximal tubule epithelial cells may be a consequence of increased expression of HSP70.	Curcumin	29-37	heat shock protein family A (Hsp70) member 4	Homo sapiens	164-169
24312824-0	2013	Comparison of inhibitory effect of curcumin nanoparticles and free curcumin in human telomerase reverse transcriptase gene expression in breast cancer.	Curcumin	67-75	telomerase reverse transcriptase	Homo sapiens	85-117
24191253-0	2013	Antidiabetic potential of the heme oxygenase-1 inducer curcumin analogues.	Curcumin	55-63	heme oxygenase 1	Homo sapiens	30-46
11322385-2	2001	Our data show that chemical treatments including sodium arsenite and curcumin, induced significant synthesis of HSP70 and its mRNA.	Curcumin	69-77	heat shock protein family A (Hsp70) member 4	Homo sapiens	112-117
11678207-3	2001	The tyrosine kinase inhibitor genistein and AP-1 inhibitor curcumin significantly blocked TGF-beta induction of VEGF expression while SP-1 and MKK1 inhibitors did not.	Curcumin	59-67	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	44-48
22957757-9	2013	TLR4 inhibitors, curcumine and resveratrol, reduced PAR(2) AP-induced vasorelaxation and PAR(2) AP-induced hypotension in both naive and endotoxaemic rats.	Curcumin	17-26	F2R like trypsin receptor 1	Rattus norvegicus	52-58
11057875-10	2000	Pretreatment of HUVECs with curcumin, an inhibitor of NF-kappaB/Rel activation, synthesis of c-Jun mRNA and binding of activated AP- I with AP-binding oligonucleotide, prevented the VT-1 induced increase in TF mRNA and activity in VT-1-stimulated HUVECs.	Curcumin	28-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	93-98
11057875-11	2000	Curcumin also inhibited NF-kappaB and AP-1 binding to TF-kappaB and proximal TF-AP-1 oligonucleotides, respectively, in a dose-dependent manner.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-42
22957757-9	2013	TLR4 inhibitors, curcumine and resveratrol, reduced PAR(2) AP-induced vasorelaxation and PAR(2) AP-induced hypotension in both naive and endotoxaemic rats.	Curcumin	17-26	F2R like trypsin receptor 1	Rattus norvegicus	89-95
11057875-11	2000	Curcumin also inhibited NF-kappaB and AP-1 binding to TF-kappaB and proximal TF-AP-1 oligonucleotides, respectively, in a dose-dependent manner.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-84
23085457-3	2013	TRAIL-induced activation of Akt catalytic activity and phosphorylation were highly correlated with p38/HSP27 phosphorylation, whereas the phosphorylation of p38/HSP27 increased further during incubation with curcumin and TRAIL, which caused significant apoptotic cell death.	Curcumin	208-216	heat shock protein family B (small) member 1	Homo sapiens	161-166
10918449-6	2000	Requirement of AP-1 for Gal-1-induced apoptosis was confirmed by the dose-dependent reduction on the level of DNA fragmentation observed when cells were pre-treated with curcumin (an inhibitor of AP-1 activation) before exposure to Gal-1.	Curcumin	170-178	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-19
10918449-6	2000	Requirement of AP-1 for Gal-1-induced apoptosis was confirmed by the dose-dependent reduction on the level of DNA fragmentation observed when cells were pre-treated with curcumin (an inhibitor of AP-1 activation) before exposure to Gal-1.	Curcumin	170-178	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	196-200
23085457-6	2013	However, further increases in p38/HSP27 phosphorylation induced by cotreatment with curcumin and TRAIL converted cell fate to death.	Curcumin	84-92	heat shock protein family B (small) member 1	Homo sapiens	34-39
23235109-7	2013	Treatment with the histone acetyltransferase (HAT) inhibitor curcumin reduces H3K9Ac levels in the NKG2D gene, downregulates NKG2D transcription and leads to a marked reduction in the lytic capacity of NKG2D-mediated NKL cells.	Curcumin	61-69	killer cell lectin like receptor C1	Homo sapiens	99-103
23970932-6	2013	We found that curcumin suppresses Sp-1 transcriptional activity and Sp-1 regulated genes including ADEM10, calmodulin, EPHB2, HDAC4, and SEPP1 in CRC cells.	Curcumin	14-22	EPH receptor B2	Homo sapiens	119-124
11023281-8	2000	The AP-1 inhibitor curcumin strongly inhibited VEGF-induced alkaline phosphatase production in human dental pulp cells.	Curcumin	19-27	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-8
23970932-6	2013	We found that curcumin suppresses Sp-1 transcriptional activity and Sp-1 regulated genes including ADEM10, calmodulin, EPHB2, HDAC4, and SEPP1 in CRC cells.	Curcumin	14-22	histone deacetylase 4	Homo sapiens	126-131
22572473-6	2013	In vivo, the ability of curcumin to counteract hippocampus-dependent spatial memory deficits, to stimulate neuroprotective mechanisms such as upregulation of BDNF, to decrease glutaminase levels, and to modulate N-methyl-D-aspartate receptor levels was absent in mice lacking functional TNFRs.	Curcumin	24-32	brain derived neurotrophic factor	Mus musculus	158-162
11360674-6	2000	Hirudin, curcumin, and c-fos antisense oligonucleotides could block thrombin-induced expression of MMP-9 mRNA as well as AP-1 binding activity.	Curcumin	9-17	matrix metallopeptidase 9	Homo sapiens	99-104
11360674-6	2000	Hirudin, curcumin, and c-fos antisense oligonucleotides could block thrombin-induced expression of MMP-9 mRNA as well as AP-1 binding activity.	Curcumin	9-17	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	121-125
11775869-7	2000	Curcumin (AP-1 inhibitor), staurosporine (PKC inhibitor), and genistein (PTK inhibitor) all reduced AP-1-mediated PAI-1 mRNA expression induced by thrombin in cultured MCs.	Curcumin	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	10-14
11775869-7	2000	Curcumin (AP-1 inhibitor), staurosporine (PKC inhibitor), and genistein (PTK inhibitor) all reduced AP-1-mediated PAI-1 mRNA expression induced by thrombin in cultured MCs.	Curcumin	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	100-104
23744438-0	2013	Down-regulation of thymic stromal lymphopoietin by curcumin.	Curcumin	51-59	thymic stromal lymphopoietin	Homo sapiens	19-47
23744438-3	2013	However, the effect of curcumin on the production of TSLP has not been clarified.	Curcumin	23-31	thymic stromal lymphopoietin	Homo sapiens	53-57
23744438-4	2013	Thus, we investigated how curcumin inhibits the expression and production of TSLP in the human mast cell line, HMC-1 cells.	Curcumin	26-34	thymic stromal lymphopoietin	Homo sapiens	77-81
10729246-6	2000	RESULTS/CONCLUSION: These results show that mucosal CD4(+) T cells and B cells increase in animals treated with curcumin, suggesting that curcumin modulates lymphocyte-mediated immune functions.	Curcumin	112-120	CD4 antigen	Mus musculus	52-55
10729246-6	2000	RESULTS/CONCLUSION: These results show that mucosal CD4(+) T cells and B cells increase in animals treated with curcumin, suggesting that curcumin modulates lymphocyte-mediated immune functions.	Curcumin	138-146	CD4 antigen	Mus musculus	52-55
10713700-12	2000	Moreover, we found that the induction of the endogenous c-met gene by HGF is inhibited by the addition of Curcumin.	Curcumin	106-114	hepatocyte growth factor	Mus musculus	70-73
23744438-6	2013	RESULTS: The results show that curcumin inhibited the production and mRNA expression of TSLP in HMC-1 cells: the maximal inhibition rate of TSLP production by curcumin (50 muM) was 59.16 +- 4.20%.	Curcumin	31-39	thymic stromal lymphopoietin	Homo sapiens	88-92
23744438-6	2013	RESULTS: The results show that curcumin inhibited the production and mRNA expression of TSLP in HMC-1 cells: the maximal inhibition rate of TSLP production by curcumin (50 muM) was 59.16 +- 4.20%.	Curcumin	31-39	thymic stromal lymphopoietin	Homo sapiens	140-144
23744438-6	2013	RESULTS: The results show that curcumin inhibited the production and mRNA expression of TSLP in HMC-1 cells: the maximal inhibition rate of TSLP production by curcumin (50 muM) was 59.16 +- 4.20%.	Curcumin	159-167	thymic stromal lymphopoietin	Homo sapiens	88-92
10611441-4	1999	The effect of curcumin on interleukin-12 p40 promoter activation was analyzed by transfecting RAW264.7 monocytic cells with p40 promoter/reporter constructs.	Curcumin	14-22	interleukin 12b	Mus musculus	41-44
23744438-6	2013	RESULTS: The results show that curcumin inhibited the production and mRNA expression of TSLP in HMC-1 cells: the maximal inhibition rate of TSLP production by curcumin (50 muM) was 59.16 +- 4.20%.	Curcumin	159-167	thymic stromal lymphopoietin	Homo sapiens	140-144
10611441-4	1999	The effect of curcumin on interleukin-12 p40 promoter activation was analyzed by transfecting RAW264.7 monocytic cells with p40 promoter/reporter constructs.	Curcumin	14-22	interleukin 12b	Mus musculus	124-127
23744438-9	2013	CONCLUSION: These results suggest that curcumin can be used to treat inflammatory and atopic diseases through the suppression of TSLP.	Curcumin	39-47	thymic stromal lymphopoietin	Homo sapiens	129-133
23544048-4	2013	We found that curcumin inhibited the EMT as assessed by reduced expression of alpha-SMA and PAI-1, and increased E-cadherin in TGF-beta1 treated proximal tubular epithelial cell HK-2 cells.	Curcumin	14-22	serpin family E member 1	Homo sapiens	92-97
24360183-1	2013	OBJECTIVE: To explore the effects of curcumin on the expression of high mobility group box1 (HMGB1) , cell viability and morphology in a cellular model of Alzheimer"s disease (AD).	Curcumin	37-45	high mobility group box 1	Rattus norvegicus	67-91
23544048-6	2013	Curcumin reduced TGF-beta receptor type I (TbetaR-I) and TGF-beta receptor type II (TbetaR II), but had no effect on phosphorylation of Smad2 and Smad3.	Curcumin	0-8	transforming growth factor beta receptor 1	Homo sapiens	17-41
24360183-1	2013	OBJECTIVE: To explore the effects of curcumin on the expression of high mobility group box1 (HMGB1) , cell viability and morphology in a cellular model of Alzheimer"s disease (AD).	Curcumin	37-45	high mobility group box 1	Rattus norvegicus	93-98
24360183-9	2013	CONCLUSION: Curcumin may reduce Abeta25-35-induced cytotoxicity through a down-regulated expression of HMGB1 and an inhibition of extracellular release of HMGB1 in PC12 cell.	Curcumin	12-20	high mobility group box 1	Rattus norvegicus	103-108
24360183-9	2013	CONCLUSION: Curcumin may reduce Abeta25-35-induced cytotoxicity through a down-regulated expression of HMGB1 and an inhibition of extracellular release of HMGB1 in PC12 cell.	Curcumin	12-20	high mobility group box 1	Rattus norvegicus	155-160
23544048-6	2013	Curcumin reduced TGF-beta receptor type I (TbetaR-I) and TGF-beta receptor type II (TbetaR II), but had no effect on phosphorylation of Smad2 and Smad3.	Curcumin	0-8	transforming growth factor beta receptor 1	Homo sapiens	43-51
10200579-8	1999	Inhibition of AP-1 factor activity caused by either anti-caspase/anti-acidotic agent Zn2+ or curcumin, an inhibitor of AP-1 binding to DNA and c-jun synthesis, protects cells from genome destruction.	Curcumin	93-101	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	143-148
23544048-8	2013	Further, the effect of curcumin on alpha-SMA, PAI-1, E-cadherin, TbetaR I and TbetaR II were reversed by ERK inhibitor U0126 or PPARgamma inhibitor BADGE, or PPARgamma shRNA.	Curcumin	23-31	serpin family E member 1	Homo sapiens	46-51
23258338-6	2012	In addition, curcumin and sphingosine-phosphate take part in the regulation of NPC1L1 expression.	Curcumin	13-21	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	79-85
23952237-5	2013	Our results show that RsTSPO behaves as a dimer in the purified state and binds with low micromolar affinity to many of these ligands, including retinoic acid, curcumin, and a known Bcl-2 inhibitor, gossypol, suggesting a possible direct role for TSPO in their regulation of apoptosis.	Curcumin	160-168	translocator protein	Homo sapiens	24-28
22445325-7	2012	Finally, additional results demonstrated that SNCA inducing both mitochondrial dynamic disorders and neurotoxicity could be ameliorated by curcumin through ERK inhibition, which implied that the agent could be used to prevent and treat PD in the future.	Curcumin	139-147	synuclein alpha	Homo sapiens	46-50
23983610-0	2013	B19, a novel monocarbonyl analogue of curcumin, induces human ovarian cancer cell apoptosis via activation of endoplasmic reticulum stress and the autophagy signaling pathway.	Curcumin	38-46	hormonally up-regulated Neu-associated kinase	Homo sapiens	0-3
23983610-11	2013	CONCLUSIONS: Our data indicate that ER stress and autophagy may play a role in the apoptosis that is induced by the curcumin analogue B19 in an epithelial ovarian cancer cell line and that autophagy inhibition can increase curcumin analogue-induced apoptosis by inducing severe ER stress.	Curcumin	116-124	hormonally up-regulated Neu-associated kinase	Homo sapiens	134-137
23194063-8	2012	The mechanism of curcumin-/RL197-induced repression of Sp transcription factors was ROS-dependent and due to induction of the Sp repressors ZBTB10 and ZBTB4 and downregulation of microRNAs (miR)-27a, miR-20a and miR-17-5p that regulate these repressors.	Curcumin	17-25	zinc finger and BTB domain containing 10	Homo sapiens	140-146
23983610-11	2013	CONCLUSIONS: Our data indicate that ER stress and autophagy may play a role in the apoptosis that is induced by the curcumin analogue B19 in an epithelial ovarian cancer cell line and that autophagy inhibition can increase curcumin analogue-induced apoptosis by inducing severe ER stress.	Curcumin	223-231	hormonally up-regulated Neu-associated kinase	Homo sapiens	134-137
22890222-4	2012	Chromatin immunoprecipitation assay confirmed that curcumin inhibits the binding of p65 to TREM-1 promoter in response to LPS.	Curcumin	51-59	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	84-87
23936448-5	2013	Curcumin exerted a powerful inhibitory effect against HIV-1 gp120-induced neuronal damage, reducing the production of ROS, TNF-alpha and MCP-1 by N9 cells and inhibiting apoptosis of primary rat cortical neurons.	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	137-142
23079001-8	2012	Single and multiple cocaine treatment regimens inhibited histone deacetylase activity, and pre-treatment with curcumin prevented cocaine-induced up-regulation of MOR protein expression.	Curcumin	110-118	opioid receptor mu 1	Homo sapiens	162-165
22653297-8	2013	Lifespan extension of curcumin in Drosophila was associated with the up-regulation of Mn-SOD and CuZn-SOD genes, and the down-regulation of dInR, ATTD, Def, CecB, and DptB genes.	Curcumin	22-30	Insulin-like receptor	Drosophila melanogaster	140-144
22653297-8	2013	Lifespan extension of curcumin in Drosophila was associated with the up-regulation of Mn-SOD and CuZn-SOD genes, and the down-regulation of dInR, ATTD, Def, CecB, and DptB genes.	Curcumin	22-30	Cecropin B	Drosophila melanogaster	157-161
23825622-8	2013	We inferred that curcumin was capable of impacting the IL-23/IL-17A axis by inhibiting IL-1beta/IL-6 and then indirectly down-regulating IL-17A/IL-22 production.	Curcumin	17-25	interleukin 17A	Mus musculus	61-67
23825622-8	2013	We inferred that curcumin was capable of impacting the IL-23/IL-17A axis by inhibiting IL-1beta/IL-6 and then indirectly down-regulating IL-17A/IL-22 production.	Curcumin	17-25	interleukin 17A	Mus musculus	137-143
23532091-8	2013	RESULTS: Both rapamycin and curcumin potently inhibited SKN and SK-UT-1 cell proliferation in a dose-dependent manner.	Curcumin	28-36	hedgehog acyltransferase	Homo sapiens	56-59
23532091-9	2013	Curcumin induced autophagy and apoptosis in SKN and SK-UT-1 cells, whereas rapamycin, a specific mTOR inhibitor, did not.	Curcumin	0-8	hedgehog acyltransferase	Homo sapiens	44-47
22221674-5	2012	Using the thioacetamide (TAA)-induced hepatic fibrosis animal model, we found that curcumin treatment up-regulated P53 protein expression and Bax messenger RNA (mRNA) expression and down-regulated Bcl-2 mRNA expression.	Curcumin	83-91	transformation related protein 53, pseudogene	Mus musculus	115-118
23532091-10	2013	Curcumin increased extracellular signal-regulated kinase 1/2 activity in both SKN and SK-UT-1 cells, whereas PD98059, an MEK1 inhibitor, inhibited both the extracellular signal-regulated kinase 1/2 pathway and curcumin-induced autophagy.	Curcumin	0-8	hedgehog acyltransferase	Homo sapiens	78-81
22978413-7	2012	RESULTS: Rats treated with curcumin improved liver necro-inflammation, and reduced liver fibrosis in association with decreased alpha-smooth muscle actin expression, and decreased collagen deposition.	Curcumin	27-35	actin gamma 2, smooth muscle	Rattus norvegicus	128-153
22978413-8	2012	Furthermore, curcumin significantly attenuated expressions of TGFbeta1, Smad2, phosphorylated Smad2, Smad3, and CTGF and induced expression of the Smad7.	Curcumin	13-21	SMAD family member 2	Rattus norvegicus	72-77
23875250-0	2013	Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha, c-Jun and androgen receptor.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	120-125
22978413-8	2012	Furthermore, curcumin significantly attenuated expressions of TGFbeta1, Smad2, phosphorylated Smad2, Smad3, and CTGF and induced expression of the Smad7.	Curcumin	13-21	SMAD family member 2	Rattus norvegicus	94-99
23875250-6	2013	Mechanistically, we found that curcumin upregulated the protein level of NF-kappaB inhibitor IkappaBalpha and downregulated protein levels of c-Jun and AR.	Curcumin	31-39	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	142-147
22978413-8	2012	Furthermore, curcumin significantly attenuated expressions of TGFbeta1, Smad2, phosphorylated Smad2, Smad3, and CTGF and induced expression of the Smad7.	Curcumin	13-21	cellular communication network factor 2	Rattus norvegicus	112-116
23660191-6	2013	Also, concerning the secretory mechanism, the significant increase in GLP-1 secretion by curcumin involved the Ca(2+)-Ca(2+)/calmodulin-dependent kinase II pathway, and was independent of extracellular signal-regulated kinase, PKC, and the cAMP/PKA-related pathway.	Curcumin	89-97	cathelicidin antimicrobial peptide	Mus musculus	240-244
22978413-9	2012	CONCLUSIONS: Curcumin significantly attenuated the severity of CCl4-induced liver inflammation and fibrosis through inhibition of TGF-beta1/Smad signalling pathway and CTGF expression.	Curcumin	13-21	cellular communication network factor 2	Rattus norvegicus	168-172
23671702-0	2013	Curcumin nanoparticles ameliorate ICAM-1 expression in TNF-alpha-treated lung epithelial cells through p47 (phox) and MAPKs/AP-1 pathways.	Curcumin	0-8	intercellular adhesion molecule 1	Homo sapiens	34-40
22949588-3	2012	The TdT-mediated dUTP-biotin nick end-labeling (TUNEL) method demonstrated that both capsaicin and curcumin induced apoptosis, with the apoptotic effect of capsaicin appearing at an early stage of application.	Curcumin	99-107	deoxynucleotidyltransferase, terminal	Mus musculus	4-7
23299930-8	2013	EF24, a molecule having structural similarity to curcumin, could synergistically enhance the antitumor effects of sorafenib and overcome sorafenib resistance through inhibiting HIF-1alpha by sequestering it in cytoplasm and promoting degradation by way of up-regulating Von Hippel-Lindau tumor suppressor (VHL).	Curcumin	49-57	von Hippel-Lindau tumor suppressor	Mus musculus	270-304
23299930-8	2013	EF24, a molecule having structural similarity to curcumin, could synergistically enhance the antitumor effects of sorafenib and overcome sorafenib resistance through inhibiting HIF-1alpha by sequestering it in cytoplasm and promoting degradation by way of up-regulating Von Hippel-Lindau tumor suppressor (VHL).	Curcumin	49-57	von Hippel-Lindau tumor suppressor	Mus musculus	306-309
22841393-0	2013	Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway.	Curcumin	0-8	vitamin D receptor	Homo sapiens	84-102
22841393-2	2013	Recent in vitro studies suggested that curcumin and polyunsaturated fatty acids (PUFAs) also bind to VDR with low affinity.	Curcumin	39-47	vitamin D receptor	Homo sapiens	101-104
23446753-9	2013	The apoptosis of Hepa1-6 cells induced by the combination treatment with curcumin and resveratrol was accompanied by caspase-3, -8 and -9 activation, which was completely abrogated by a pan caspase inhibitor, Z-VAD-FMK.	Curcumin	73-81	caspase 3	Mus musculus	117-137
22909087-7	2012	The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1beta, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-alpha.	Curcumin	27-35	matrix metallopeptidase 1	Homo sapiens	143-147
23446753-11	2013	The ROS scavenger, NAC, partially attenuated the apoptosis and caspase activation induced by the combination treatment of curcumin and resveratrol.	Curcumin	122-130	NLR family, pyrin domain containing 1A	Mus musculus	19-22
22594559-4	2012	Inhibition of SphK1 by SKI-II or by RNA interference (RNAi) knockdown dramatically enhanced curcumin-induced apoptosis and growth inhibition in ovarian cancer cells.	Curcumin	92-100	sphingosine kinase 1	Homo sapiens	14-19
22507634-8	2012	Knockdown of alpha1-antitrypsin by siRNA further enhanced the tumor cell proliferation induced by neutrophil elastase and significantly blocked the anti-proliferation effect of curcumin against neutrophil elastase.	Curcumin	177-185	elastase, neutrophil expressed	Mus musculus	194-213
22507634-10	2012	We further showed that curcumin upregulated the level of alpha1-antitrypsin in primary tumor tissue by promoting its local expression, and the protein level of neutrophil elastase in tumor tissue was obviously decreased in mice treated with curcumin.	Curcumin	241-249	elastase, neutrophil expressed	Mus musculus	160-179
23410788-13	2013	The increase in the matrix proteins, glial fibrillary acidic protein and vimentin in lupus mice in the hippocampus was prevented by curcumin.	Curcumin	132-140	vimentin	Mus musculus	73-81
22507634-11	2012	Overall, our results suggest that neutrophil elastase and alpha1-antitrypsin play important roles in modulating lung tumor proliferation in inflammatory microenvironment and curcumin inhibits neutrophil elastase-induced tumor proliferation via upregulating alpha1-antitrypsin expression in vitro and in vivo.	Curcumin	174-182	elastase, neutrophil expressed	Mus musculus	192-211
22830632-7	2012	An inducing effect of curcumin and quercetin on GST or UGT was seen in Caco-2, LT97, and HuTu 80 cells.	Curcumin	22-30	glutathione S-transferase kappa 1	Homo sapiens	48-51
22551677-1	2012	Sixty-one curcumin-related compounds were synthesized and evaluated for their anticancer activity toward cultured prostate cancer PC-3 cells, pancreas cancer Panc-1 cells and colon cancer HT-29 cells.	Curcumin	10-18	proprotein convertase subtilisin/kexin type 1	Homo sapiens	130-134
23497378-1	2013	BACKGROUND: Curcumin exhibits anti-diabetic activities, induces heme-oxygenase-1 (HO-1) and is an inhibitor of transcriptional co-activator p300.	Curcumin	12-20	heme oxygenase 1	Rattus norvegicus	64-80
23497378-1	2013	BACKGROUND: Curcumin exhibits anti-diabetic activities, induces heme-oxygenase-1 (HO-1) and is an inhibitor of transcriptional co-activator p300.	Curcumin	12-20	heme oxygenase 1	Rattus norvegicus	82-86
23506591-13	2013	Curcumin reduced the injury-induced thermal and mechanical hyperalgesia, the increase in the fluorescence intensity of GFAP and the hypertrophy of astrocytic soma, activation of GFAP and phosphorylation of ERK in the spinal dorsal horn.	Curcumin	0-8	glial fibrillary acidic protein	Rattus norvegicus	119-123
23506591-13	2013	Curcumin reduced the injury-induced thermal and mechanical hyperalgesia, the increase in the fluorescence intensity of GFAP and the hypertrophy of astrocytic soma, activation of GFAP and phosphorylation of ERK in the spinal dorsal horn.	Curcumin	0-8	glial fibrillary acidic protein	Rattus norvegicus	178-182
23662249-4	2013	Here, we studied the effect of natural polyphenols resveratrol, curcumin, quercetin and analogs on LSD1.	Curcumin	64-72	lysine demethylase 1A	Homo sapiens	99-103
23662249-5	2013	Using in vitro LSD1 enzymatic assays, we show that resveratrol, curcumin and quercetin displayed a potent inhibitory effect on the LSD1 activity and were more potent than the known LSD1 inhibitor trans-2-phenylcyclopropylamine (TCP).	Curcumin	64-72	lysine demethylase 1A	Homo sapiens	15-19
23662249-5	2013	Using in vitro LSD1 enzymatic assays, we show that resveratrol, curcumin and quercetin displayed a potent inhibitory effect on the LSD1 activity and were more potent than the known LSD1 inhibitor trans-2-phenylcyclopropylamine (TCP).	Curcumin	64-72	lysine demethylase 1A	Homo sapiens	131-135
23662249-5	2013	Using in vitro LSD1 enzymatic assays, we show that resveratrol, curcumin and quercetin displayed a potent inhibitory effect on the LSD1 activity and were more potent than the known LSD1 inhibitor trans-2-phenylcyclopropylamine (TCP).	Curcumin	64-72	lysine demethylase 1A	Homo sapiens	131-135
9663426-0	1998	Curcumin inhibits SK-Hep-1 hepatocellular carcinoma cell invasion in vitro and suppresses matrix metalloproteinase-9 secretion.	Curcumin	0-8	DNL-type zinc finger	Homo sapiens	21-26
9663426-0	1998	Curcumin inhibits SK-Hep-1 hepatocellular carcinoma cell invasion in vitro and suppresses matrix metalloproteinase-9 secretion.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	90-116
9663426-7	1998	We found that curcumin, at 10 microM, inhibited 17.4 and 70.6% of cellular migration and invasion of SK-Hep-1, respectively.	Curcumin	14-22	DNL-type zinc finger	Homo sapiens	104-109
9663426-9	1998	Further, and parallel with its anti-invasion activity, curcumin inhibited MMP-9 secretion in SK-Hep-1 in a dose-dependent fashion.	Curcumin	55-63	matrix metallopeptidase 9	Homo sapiens	74-79
9663426-9	1998	Further, and parallel with its anti-invasion activity, curcumin inhibited MMP-9 secretion in SK-Hep-1 in a dose-dependent fashion.	Curcumin	55-63	DNL-type zinc finger	Homo sapiens	96-101
9663426-10	1998	We conclude that curcumin has a significant anti-invasion activity in SK-Hep-1 cells, and that this effect is associated with its inhibitory action on MMP-9 secretion.	Curcumin	17-25	DNL-type zinc finger	Homo sapiens	73-78
9663426-10	1998	We conclude that curcumin has a significant anti-invasion activity in SK-Hep-1 cells, and that this effect is associated with its inhibitory action on MMP-9 secretion.	Curcumin	17-25	matrix metallopeptidase 9	Homo sapiens	151-156
9242631-4	1997	The Sp1 inhibitor mithramycin blocked stimulation of alpha2(I) collagen mRNA accumulation by TGF-beta, whereas the AP1 inhibitor curcumin had no effect.	Curcumin	129-137	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	115-118
9049662-6	1997	In vitro incubation of YAC-1 and EL4 tumor cells and normal splenocytes in varying concentrations of curcumin for varying times revealed differences between cell types in curcumin"s effects on cell proliferation and viability.	Curcumin	101-109	epilepsy 4	Mus musculus	33-36
9049662-6	1997	In vitro incubation of YAC-1 and EL4 tumor cells and normal splenocytes in varying concentrations of curcumin for varying times revealed differences between cell types in curcumin"s effects on cell proliferation and viability.	Curcumin	171-179	epilepsy 4	Mus musculus	33-36
9112257-1	1997	Treatment of human promyelocytic leukemia HL-60 cells with 10 muM curcumin for 48 h inhibited cellular proliferation and induced small increases in differentiation (100-200%) as measured by the proportion of cells that reduced nitroblue tetrazolium (NBT) and expressed Mac-1.	Curcumin	66-74	integrin subunit alpha M	Homo sapiens	269-274
8950193-7	1996	The antioxidants, N-acetyl-L-cysteine (NAC), L-ascorbic acid, alpha-tocopherol, catalase and superoxide dismutase, all effectively prevented curcumin-induced apoptosis.	Curcumin	141-149	X-linked Kx blood group	Homo sapiens	39-42
8993955-8	1996	Pretreatment of mice with curcumin significantly abrogated the TPA-induced changes in ODC activity and the dermal infiltrating inflammatory cells as well as the TPA plus UVA-mediated enhancement of these changes.	Curcumin	26-34	ornithine decarboxylase, structural 1	Mus musculus	86-89
7592995-5	1995	Ceramide-induced growth inhibition and DNA fragmentation were both prevented by treatment with curcumin, 1,7-bis[4-hydroxy-3-methoxy-phenyl]-1,6-heptadiene-3,5-dione (an inhibitor of AP-1 activation), or antisense oligonucleotides for c-jun.	Curcumin	95-103	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	183-187
7592995-5	1995	Ceramide-induced growth inhibition and DNA fragmentation were both prevented by treatment with curcumin, 1,7-bis[4-hydroxy-3-methoxy-phenyl]-1,6-heptadiene-3,5-dione (an inhibitor of AP-1 activation), or antisense oligonucleotides for c-jun.	Curcumin	95-103	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	235-240
8941755-4	1995	However apoptosis is inhibited by curcumin, a specific inhibitor of c-jun/AP-1.	Curcumin	34-42	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-73
8941755-4	1995	However apoptosis is inhibited by curcumin, a specific inhibitor of c-jun/AP-1.	Curcumin	34-42	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-78
1314741-0	1992	Curcumin inhibits nitrite-induced methemoglobin formation.	Curcumin	0-8	hemoglobin subunit gamma 2	Homo sapiens	34-47
1314741-1	1992	Curcumin protects hemoglobin from nitrite-induced oxidation to methemoglobin.	Curcumin	0-8	hemoglobin subunit gamma 2	Homo sapiens	63-76
1908616-3	1991	Curcumin is a potent inhibitor of TPA-induced ornithine decarboxylase activity and inflammation in mouse skin whereas chlorogenic acid, caffeic acid and ferulic acid are only weakly active or inactive.	Curcumin	0-8	ornithine decarboxylase, structural 1	Mus musculus	46-69
33798807-4	2021	In in vivo experiments, curcumin significantly alleviated lung inflammation, histopathological injury and MPO activity, serum concentrations of CCL7, IL-6 and TNF-alpha, and mortality in mice compared to the model group.	Curcumin	24-32	myeloperoxidase	Mus musculus	106-109
33798807-4	2021	In in vivo experiments, curcumin significantly alleviated lung inflammation, histopathological injury and MPO activity, serum concentrations of CCL7, IL-6 and TNF-alpha, and mortality in mice compared to the model group.	Curcumin	24-32	chemokine (C-C motif) ligand 7	Mus musculus	144-148
33804820-0	2021	Beneficial Impacts of Alpha-Eleostearic Acid from Wild Bitter Melon and Curcumin on Promotion of CDGSH Iron-Sulfur Domain 2: Therapeutic Roles in CNS Injuries and Diseases.	Curcumin	72-80	CDGSH iron sulfur domain 2	Homo sapiens	97-123
33804820-10	2021	), and curcumin, a polyphenol derived from rhizomes of Curcuma longa L. In this review, the unique function of the CISD2-elevating effect of alpha-ESA and curcumin are particularly emphasized, and these natural compounds are expected to serve as a potential therapeutic target for CNS injuries and diseases.	Curcumin	155-163	CDGSH iron sulfur domain 2	Homo sapiens	115-120
33237490-8	2021	Curcumin and BA + curcumin combination showed an enhancement in synaptophysin levels of Abeta1-42-induced synaptosomes (P < 0.01).	Curcumin	0-8	synaptophysin	Rattus norvegicus	64-77
30227240-10	2018	Curcumin LPMPs remarkably attenuated lung injuries, decreased hydroxyproline contents, reduced the synthesis of collagen I, and inhibited the expressions of TNF-alpha, TGF-beta1, NF-kappaB p65 and MMP9.	Curcumin	0-8	matrix metallopeptidase 9	Rattus norvegicus	197-201
34894517-7	2022	Furthermore, The genes encoding Col1a1, Fasn, Pck1, Bmp10, IL33 and Figf were pivotal and possible key genes for the therapeutic mechanisms of curcumin.Curcumin can reduce the degree of left atrial fibrosis of AF and the secretion of inflammatory factors.	Curcumin	143-151	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	46-50
34894517-7	2022	Furthermore, The genes encoding Col1a1, Fasn, Pck1, Bmp10, IL33 and Figf were pivotal and possible key genes for the therapeutic mechanisms of curcumin.Curcumin can reduce the degree of left atrial fibrosis of AF and the secretion of inflammatory factors.	Curcumin	152-160	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	46-50
34894517-9	2022	Besides, COL1A1, FASN, PCK1, BMP10, IL33 and FIGF were the pivotal genes associated with mechanisms of action of curcumin on AF.	Curcumin	113-121	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	23-27
34894518-10	2022	CM supplementation (25 mg/kg) significantly decreased serum p53, TNF-alpha, CRP and IL-6 compared with MF.	Curcumin	0-2	C-reactive protein, pentraxin-related	Mus musculus	76-79
34894518-12	2022	MF activated caspase-3 while supplementation with CM significantly decreased this effect.	Curcumin	50-52	caspase 3	Mus musculus	13-22
34865233-0	2022	Curcumin plays a local anti-inflammatory and antioxidant role via the HMGB1/TLR4/NF-KappaB pathway in rat masseter muscle under psychological stress.	Curcumin	0-8	high mobility group box 1	Rattus norvegicus	70-75
34865233-12	2022	Mechanistically, increased levels of phosphorylated NF-kappaB, toll-like receptor 4, and HMGB1 were observed, which were also ameliorated by curcumin treatment.	Curcumin	141-149	high mobility group box 1	Rattus norvegicus	89-94
34865233-14	2022	Psychological stress activates HMGB1 expression and increases the expression of downstream TLR4 and p-NF-kappaB, which could be reduced by curcumin.	Curcumin	139-147	high mobility group box 1	Rattus norvegicus	31-36
34865233-15	2022	Thus, curcumin might exert anti-inflammatory and antioxidant effects in masseter muscles via the HMGB1/TLR4/NF-kappaB pathway.	Curcumin	6-14	high mobility group box 1	Rattus norvegicus	97-102
34634291-6	2022	Autophagy was markedly induced by curcumin treatment as evidenced by an increase in LC3-II conversion, beclin-1 accumulation, p62 degradation as well as the increased formation of acidic vesicular organelles (AVOs).	Curcumin	34-42	beclin 1	Homo sapiens	103-111
34634291-6	2022	Autophagy was markedly induced by curcumin treatment as evidenced by an increase in LC3-II conversion, beclin-1 accumulation, p62 degradation as well as the increased formation of acidic vesicular organelles (AVOs).	Curcumin	34-42	nucleoporin 62	Homo sapiens	126-129
34939316-9	2022	Curcumin reduced the expression of the genes analysed, especially MMP-9, TGF-beta and collagen I.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	66-71
34939316-10	2022	Moreover, curcumin inhibited the HRV-induced expression of MMP-9, TGF-beta, collagen I and LTC4S (p < 0.05).	Curcumin	10-18	matrix metallopeptidase 9	Homo sapiens	59-64
34357837-7	2021	RESULTS: In vivo, curcumin reduced the size of the prostate, suppressed the expression of vimentin and TLR4, and increased the expression of E-cadherin and BAMBI in the LPS-induced BPH mouse model.	Curcumin	18-26	vimentin	Mus musculus	90-98
34789266-4	2021	RESULTS: By combining nerve growth factor (NGF) and curcumin (Cur), we prepared stable engineered extracellular vesicles of approximately 120 nm from primary M2 macrophages with anti-inflammatory and neuroprotective properties (Cur@EVs-cl-NGF).	Curcumin	52-60	nerve growth factor	Mus musculus	239-242
34789266-7	2021	Subsequently, Cur@EVs-cl-NGF reached the injured site and could effectively inhibit the uncontrollable inflammatory response to protect the spinal cord from secondary damage; in addition, Cur@EVs-cl-NGF could release NGF into the microenvironment in time to exert a neuroprotective effect against nerve cell damage.	Curcumin	14-18	nerve growth factor	Mus musculus	25-28
34789266-7	2021	Subsequently, Cur@EVs-cl-NGF reached the injured site and could effectively inhibit the uncontrollable inflammatory response to protect the spinal cord from secondary damage; in addition, Cur@EVs-cl-NGF could release NGF into the microenvironment in time to exert a neuroprotective effect against nerve cell damage.	Curcumin	14-18	nerve growth factor	Mus musculus	199-202
34789266-7	2021	Subsequently, Cur@EVs-cl-NGF reached the injured site and could effectively inhibit the uncontrollable inflammatory response to protect the spinal cord from secondary damage; in addition, Cur@EVs-cl-NGF could release NGF into the microenvironment in time to exert a neuroprotective effect against nerve cell damage.	Curcumin	14-18	nerve growth factor	Mus musculus	217-220
34555398-0	2021	Cardio-protective effect of tetrahydrocurcumin, the primary hydrogenated metabolite of curcumin in vivo and in vitro: Induction of apoptosis and autophagy via PI3K/AKT/mTOR pathways.	Curcumin	87-95	mechanistic target of rapamycin kinase	Rattus norvegicus	168-172
34592487-12	2021	In addition, Curcumin inhibited expression of CD4+CD25+FoxP3+ Treg cells as well as PD-1 and TIM-3.	Curcumin	13-21	CD4 antigen	Mus musculus	46-49
23356851-7	2013	These results may be attributed to the dual inhibitory effects of probenecid, to a greater extent, on metabolism via glucuronidation, and to a lesser extent, on the biliary excretion of curcumin via the multidrug resistance-associated protein 2.	Curcumin	186-194	ATP binding cassette subfamily C member 2	Rattus norvegicus	203-244
23254361-5	2013	HO-1 inducers, hemin and curcumin, were daily administrated in the last 6 weeks in the treated groups after 2 weeks of induction.	Curcumin	25-33	heme oxygenase 1	Rattus norvegicus	0-4
23254361-7	2013	While not affected by diabetes, HO-1 protein expression was strongly induced by hemin or curcumin administration.	Curcumin	89-97	heme oxygenase 1	Rattus norvegicus	32-36
23254361-9	2013	Induction of HO-1 by hemin or curcumin significantly reduced elevated systolic BP and abolished elevated pulse BP without affecting the developed hyperglycemia or AGEs level.	Curcumin	30-38	heme oxygenase 1	Rattus norvegicus	13-17
23254361-11	2013	Diabetes increased contractile response of the aorta to PE and KCl, while HO-1 induction by curcumin or hemin prevented aorta-exaggerated response to PE and KCl.	Curcumin	92-100	heme oxygenase 1	Rattus norvegicus	74-78
34592487-13	2021	CONCLUSIONS: These results show that Curcumin reinvigorates defective T cells via multiple (PD-1 and TIM-3) and multi-level (IC receptors and its ligands) IC axis suppression, thus providing a rationale to combine Curcumin with conventional targeted therapy or ICB as a multi-faceted approach for treating patients with HNSCC.	Curcumin	37-45	hepatitis A virus cellular receptor 2	Homo sapiens	101-106
23556332-5	2013	The stabilizing effect of the Pluronics against hydrolytic degradation of curcumin was only detectable at pH 8.0-8.8, and it was highest for F127 and lowest for P85, in phosphate buffer pH 8.8.	Curcumin	74-82	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	161-164
22551677-5	2012	E10 was 72-, 46- and 117-fold more active than curcumin for inhibiting the growth of PC-3, Panc-1 and HT-29 cells, respectively.	Curcumin	47-55	proprotein convertase subtilisin/kexin type 1	Homo sapiens	85-89
23142609-0	2013	Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF.	Curcumin	31-39	brain-derived neurotrophic factor	Rattus norvegicus	117-121
22551677-6	2012	F10 was 69-, 34- and 72-fold more active than curcumin for inhibiting the growth of PC-3, Panc-1 and HT-29 cells, respectively.	Curcumin	46-54	proprotein convertase subtilisin/kexin type 1	Homo sapiens	84-88
23142609-4	2013	Moreover, since brain derived neurotrophic factor (BDNF) has been implicated in antidepressant effects of many drugs, we also evaluated the effects of curcumin on BDNF in the hippocampus.	Curcumin	151-159	brain-derived neurotrophic factor	Rattus norvegicus	163-167
23142609-9	2013	Chronic curcumin also resulted in a dose-dependent increase in hippocampal BDNF.	Curcumin	8-16	brain-derived neurotrophic factor	Rattus norvegicus	75-79
34428436-5	2021	Furthermore, curcumin treatment (50 mg/kg and 200 mg/kg, intragastrically) for 21 consecutive days suppressed the IMQ exposure-induced increase in PGRN expression.	Curcumin	13-21	granulin	Mus musculus	147-151
22552693-6	2012	Both p65 siRNA and curcumin mediated suppression of activation of the NF-kappaB signaling pathway via inhibition of the expression of p65 or IkappaBalpha phosphorylation in ESCC cell lines.	Curcumin	19-27	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	134-137
34664820-8	2021	However, a major increase in the repairer fusion gene (Mfn1, 6-fold) and complete suppression of the ASC gene were the outcomes of using the curcumin.	Curcumin	141-149	mitofusin 1	Homo sapiens	55-59
23294827-2	2013	Curcumin up-regulates heat shock protein 70 (hsp70) mRNA in several different cancer cell lines.	Curcumin	0-8	heat shock protein family A (Hsp70) member 4	Homo sapiens	22-43
23276449-2	2013	Curcumin (CM), a turmeric-derived bioactive polyphenol found in curry, has recently been identified as a ligand for the vitamin D receptor (VDR), and it is possible that CM exerts some of its bioeffects via direct binding to VDR and/or other proteins in the nuclear receptor superfamily.	Curcumin	0-8	vitamin D receptor	Homo sapiens	140-143
23276449-2	2013	Curcumin (CM), a turmeric-derived bioactive polyphenol found in curry, has recently been identified as a ligand for the vitamin D receptor (VDR), and it is possible that CM exerts some of its bioeffects via direct binding to VDR and/or other proteins in the nuclear receptor superfamily.	Curcumin	0-8	vitamin D receptor	Homo sapiens	225-228
22183741-7	2012	In addition, treatment of endometriotic stromal cells with curcumin markedly inhibited TNF-alpha-induced secretion of IL-6, IL-8 and MCP-1.	Curcumin	59-67	C-C motif chemokine ligand 2	Homo sapiens	133-138
34589382-0	2021	Curcumin Alleviates Oxygen-Glucose-Deprivation/Reperfusion-Induced Oxidative Damage by Regulating miR-1287-5p/LONP2 Axis in SH-SY5Y Cells.	Curcumin	0-8	lon peptidase 2, peroxisomal	Homo sapiens	110-115
34567209-6	2021	Additionally, curcumin significantly downregulated CD11b+F4/80+TLR4+ macrophages and the protein levels of TLR2, TLR4, MyD88, NF-kappaBp65, p38MAPK, and AP-1 in colitis mice.	Curcumin	14-22	adhesion G protein-coupled receptor E1	Mus musculus	57-62
22782502-6	2013	Finally, alternative, low-affinity, non-vitamin D VDR ligands, e.g., lithocholic acid, docosahexaenoic acid, and curcumin, have been reported.	Curcumin	113-121	vitamin D receptor	Homo sapiens	50-53
34567209-6	2021	Additionally, curcumin significantly downregulated CD11b+F4/80+TLR4+ macrophages and the protein levels of TLR2, TLR4, MyD88, NF-kappaBp65, p38MAPK, and AP-1 in colitis mice.	Curcumin	14-22	myeloid differentiation primary response gene 88	Mus musculus	119-124
22591841-8	2012	The activity of CURCUMIN was also evidenced from the inhibition of macrophages proliferation (HBEGF), related to a strong down regulation of TNFalpha and to activation of fibrinolysis (SERPINE1).	Curcumin	16-24	tumor necrosis factor	Canis lupus familiaris	141-149
34448459-0	2021	Curcumin attenuates renal ischemia reperfusion injury via JNK pathway with the involvement of p300/CBP-mediated histone acetylation.	Curcumin	0-8	CREB binding protein	Rattus norvegicus	99-102
22483553-9	2012	Expression of HIF-1alpha-dependent P-gp also seemed to decrease as response to curcumin in a dose-dependent manner.	Curcumin	79-87	phosphoglycolate phosphatase	Homo sapiens	35-39
34448459-6	2021	Treatment with curcumin in IRI rats also led to the decrease in expression of p300/cyclic AMP response element-binding protein (CBP) and activity of histone acetyltransferases (HATs).	Curcumin	15-23	CREB binding protein	Rattus norvegicus	128-131
34448459-9	2021	In addition, SP600125 suppressed the binding level of p300/CBP and H3K9 acetylation near the promoter region of caspase-3/-9, and curcumin could inhibit JNK phosphorylation like SP600125.	Curcumin	130-138	CREB binding protein	Rattus norvegicus	59-62
34448459-10	2021	These results indicate that curcumin could attenuate renal IRI via JNK/p300/CBP-mediated anti-apoptosis signaling.	Curcumin	28-36	CREB binding protein	Rattus norvegicus	76-79
22522053-6	2012	Curcumin induced upregulation of Fas, FasL, and DR5 expression in chondrosarcoma cells.	Curcumin	0-8	Fas ligand	Homo sapiens	38-42
34462629-6	2021	In vitro, curcumin decreased LPS/IFNgamma-elevated M1 macrophage marker (iNOS and CD86) expression and the proportion of M1 macrophages (iNOS+F4/80+ cells) but increased LPS/IFNgamma-suppressed M2 macrophage marker (Arg1 and CD206) expression and the proportion of M2 macrophages (Arg1+F4/80+ cells).	Curcumin	10-18	mannose receptor, C type 1	Mus musculus	225-230
34323067-0	2021	Regulation on Citrate Influx and Metabolism through Inhibiting SLC13A5 and ACLY: A Novel Mechanism Mediating the Therapeutic Effects of Curcumin on NAFLD.	Curcumin	136-144	ATP citrate lyase	Homo sapiens	75-79
34323067-7	2021	In OPA-stimulated HepG2 cells, curcumin rectified the dysregulated expression of SLC13A5/ACLY possibly via the AMPK-mTOR signaling pathway.	Curcumin	31-39	ATP citrate lyase	Homo sapiens	89-93
34323067-8	2021	Besides, curcumin also functionally inhibited both citrate transport and metabolism mediated by SLC13A5 and ACLY, respectively.	Curcumin	9-17	ATP citrate lyase	Homo sapiens	108-112
23127801-0	2013	Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway.	Curcumin	0-8	sphingosine kinase 1	Rattus norvegicus	78-83
23127801-4	2013	This study aims to investigate whether the renoprotective effects of curcumin on DN are associated with its inhibitory effects on the SphK1-S1P signaling pathway.	Curcumin	69-77	sphingosine kinase 1	Rattus norvegicus	134-139
23127801-5	2013	Our results demonstrated that the expression and activity of SphK1 and the production of S1P were significantly down-regulated by curcumin in diabetic rat kidneys and glomerular mesangial cells (GMCs) exposed to high glucose (HG).	Curcumin	130-138	sphingosine kinase 1	Rattus norvegicus	61-66
23127801-7	2013	In addition, curcumin dose dependently reduced SphK1 expression and activity in GMCs transfected with SphK(WT) and significantly suppressed the increase in SphK1-mediated FN levels.	Curcumin	13-21	sphingosine kinase 1	Rattus norvegicus	47-52
23127801-7	2013	In addition, curcumin dose dependently reduced SphK1 expression and activity in GMCs transfected with SphK(WT) and significantly suppressed the increase in SphK1-mediated FN levels.	Curcumin	13-21	sphingosine kinase 1	Rattus norvegicus	156-161
23127801-8	2013	Furthermore, curcumin inhibited the DNA-binding activity of activator protein 1 (AP-1), and c-Jun small interference RNA (c-Jun-siRNA) reversed the HG-induced up-regulation of SphK1.	Curcumin	13-21	sphingosine kinase 1	Rattus norvegicus	176-181
23127801-9	2013	These findings suggested that down-regulation of the SphK1-S1P pathway is probably a novel mechanism by which curcumin improves the progression of DN.	Curcumin	110-118	sphingosine kinase 1	Rattus norvegicus	53-58
23127801-10	2013	Inhibiting AP-1 activation is one of the therapeutic targets of curcumin to modulate the SphK1-S1P signaling pathway, thereby preventing diabetic renal fibrosis.	Curcumin	64-72	sphingosine kinase 1	Rattus norvegicus	89-94
34439491-8	2021	Inhibition of TRPM2 by curcumin and other "natural" compounds offers an attractive strategy for inhibiting ROS-induced liver cell injury.	Curcumin	23-31	transient receptor potential cation channel subfamily M member 2	Homo sapiens	14-19
34355287-5	2021	METHODS: The effect of curcumin and BDMC-A on transcription factors (NF-kappaB, p65, c-Jun, c-Fos, STAT3, 5, PPAR-gamma, beta-catenin, COX-2, MMP-9, VEGF, TIMP-2) involved in signal transduction cascade, invasion, and angiogenesis in Hep-2 cells were quantified using Western blotting and RT-PCR technique.	Curcumin	23-31	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	92-97
34355287-5	2021	METHODS: The effect of curcumin and BDMC-A on transcription factors (NF-kappaB, p65, c-Jun, c-Fos, STAT3, 5, PPAR-gamma, beta-catenin, COX-2, MMP-9, VEGF, TIMP-2) involved in signal transduction cascade, invasion, and angiogenesis in Hep-2 cells were quantified using Western blotting and RT-PCR technique.	Curcumin	23-31	matrix metallopeptidase 9	Homo sapiens	142-147
22522053-6	2012	Curcumin induced upregulation of Fas, FasL, and DR5 expression in chondrosarcoma cells.	Curcumin	0-8	TNF receptor superfamily member 10b	Homo sapiens	48-51
34355287-5	2021	METHODS: The effect of curcumin and BDMC-A on transcription factors (NF-kappaB, p65, c-Jun, c-Fos, STAT3, 5, PPAR-gamma, beta-catenin, COX-2, MMP-9, VEGF, TIMP-2) involved in signal transduction cascade, invasion, and angiogenesis in Hep-2 cells were quantified using Western blotting and RT-PCR technique.	Curcumin	23-31	TIMP metallopeptidase inhibitor 2	Homo sapiens	155-161
22522053-7	2012	Transfection of cells with Fas, FasL, or DR5 siRNA reduced curcumin-induced cell death.	Curcumin	59-67	Fas ligand	Homo sapiens	32-36
34257809-17	2021	Besides, in vivo studies also showed that when applied in combination, curcumin and probucol could block the PI3K-AKT-mTOR signaling pathway; promote COL-II expression; suppress P62, MMP-3, and MMP-13 expression; and inhibit TNF-alpha-stimulated cartilage degradation.	Curcumin	71-79	nucleoporin 62	Homo sapiens	178-181
22522053-7	2012	Transfection of cells with Fas, FasL, or DR5 siRNA reduced curcumin-induced cell death.	Curcumin	59-67	TNF receptor superfamily member 10b	Homo sapiens	41-44
34981488-10	2021	Therefore, prolonged use or the use of curcumin with antiviral agents in addition to clinical signs and symptoms can reduce the HTLV-1 proviral load and the expression of functional viral factors such as Tax and HBZ.	Curcumin	39-47	hemoglobin subunit zeta	Homo sapiens	212-215
22729592-6	2013	Curcumin supplementation increased plasma concentrations of angiogenic factors angiogenin (p &lt; 0.05), basic fibroblast growth factor (p &lt; 0.05) and vascular endothelial growth factor (p &lt; 0.05), as well as inflammatory cytokines interleukin-1beta (p &lt; 0.05) and monocyte chemotactic protein-1 (p &lt; 0.05), compared to the controls.	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	274-304
22522053-8	2012	In addition, p53 involved in curcumin-mediated Fas, FasL, and DR5 expression and cell apoptosis in chondrosarcoma cells.	Curcumin	29-37	Fas ligand	Homo sapiens	52-56
23991988-6	2013	RESULTS: We showed that the combination of curcumin and triptolide could synergistically inhibit ovarian cancer cell growth, and induce apoptosis, which is accompanied by HSP27 and HSP70, indicating that HSP27 and HSP70 play the important role in the synergic effect.	Curcumin	43-51	heat shock protein family A (Hsp70) member 4	Homo sapiens	181-186
34109908-6	2021	The results of western blotting showed that curcumin down-regulated the expression of nucleotide-binding oligomerization domain-containing protein-, leucine-rich repeats-, and pyrin domain-containing protein 1 (NLRP1), cysteinyl aspartate-specific protease 1 (caspase-1), gasdermin D (GSDMD), IL-1beta, IL-6, TNF-alpha, and iNOS proteins in OGD and MCAO models.	Curcumin	44-52	caspase 1	Rattus norvegicus	219-258
34109908-6	2021	The results of western blotting showed that curcumin down-regulated the expression of nucleotide-binding oligomerization domain-containing protein-, leucine-rich repeats-, and pyrin domain-containing protein 1 (NLRP1), cysteinyl aspartate-specific protease 1 (caspase-1), gasdermin D (GSDMD), IL-1beta, IL-6, TNF-alpha, and iNOS proteins in OGD and MCAO models.	Curcumin	44-52	caspase 1	Rattus norvegicus	260-269
23991988-6	2013	RESULTS: We showed that the combination of curcumin and triptolide could synergistically inhibit ovarian cancer cell growth, and induce apoptosis, which is accompanied by HSP27 and HSP70, indicating that HSP27 and HSP70 play the important role in the synergic effect.	Curcumin	43-51	heat shock protein family A (Hsp70) member 4	Homo sapiens	214-219
22522053-8	2012	In addition, p53 involved in curcumin-mediated Fas, FasL, and DR5 expression and cell apoptosis in chondrosarcoma cells.	Curcumin	29-37	TNF receptor superfamily member 10b	Homo sapiens	62-65
34284543-0	2021	Curcumin promotes the proliferation, invasion of neural stem cells and formation of neurospheres via activating SDF-1/CXCR4 axis.	Curcumin	0-8	C-X-C motif chemokine receptor 4	Rattus norvegicus	118-123
22475723-4	2012	This study was designed to identify proteins involved in the anticancer activity of curcumin in androgen-dependent (22Rv1) and -independent (PC-3) human prostate cancer cell lines using two-dimensional difference in gel electrophoresis (2D-DIGE).	Curcumin	84-92	proprotein convertase subtilisin/kexin type 1	Homo sapiens	141-145
34284543-7	2021	In addition, Curcumin up-regulated the expression of SDF-1 and promoted the formation of SDF-1/CXCR4 complex in NSCs.	Curcumin	13-21	C-X-C motif chemokine receptor 4	Rattus norvegicus	95-100
34284543-10	2021	These results suggested that curcumin promoted the NSCs proliferation, migration and formation of neurospheres via SDF-1/CXCR4 in NSCs.	Curcumin	29-37	C-X-C motif chemokine receptor 4	Rattus norvegicus	121-126
22237476-5	2012	RESULTS: Curcumin and BDMC inhibited LPS-induced barrier permeability, monocyte adhesion and migration; inhibitory effects were significantly correlated with inhibitory functions of curcumin and BDMC on LPS-induced cell adhesion molecules (vascular cell adhesion molecules, intracellular cell adhesion molecule, E-selectin).	Curcumin	9-17	selectin E	Homo sapiens	312-322
35487055-9	2022	Generally, both cell lines treated with the combination of Curcumin and As2O3 displayed decreased angiogenesis genes (VEGFA and VEGFC), apoptosis genes (BAX and Bcl2), and prostate cancer marker (KLK2), the zinc-finger protein (SNAIL); and an increase in expression (P < 0.05) of cell-cell adhesion molecule (E-cadherin) and tumor suppressor gene (P53) genes.	Curcumin	59-67	kallikrein related peptidase 2	Homo sapiens	196-200
35574627-1	2022	To quantify the effects of curcumin supplementation on exercise-induced muscle damage, muscle soreness, inflammatory biomarkers, muscle strength, and joint flexibility via assessment of creatine kinase (CK), visual analogue scale (VAS) score, maximal voluntary contraction (MVC), and range of motion (ROM), respectively.	Curcumin	27-35	cytidine/uridine monophosphate kinase 1	Homo sapiens	186-201
35574627-1	2022	To quantify the effects of curcumin supplementation on exercise-induced muscle damage, muscle soreness, inflammatory biomarkers, muscle strength, and joint flexibility via assessment of creatine kinase (CK), visual analogue scale (VAS) score, maximal voluntary contraction (MVC), and range of motion (ROM), respectively.	Curcumin	27-35	cytidine/uridine monophosphate kinase 1	Homo sapiens	203-205
35574627-7	2022	Meta-analysis showed that curcumin supplementation significantly reduced serum CK activity (WMD = -65.98 IU/L, 95% CI (-99.53 to -32.44)), muscle soreness (WMD = -0.56, 95% CI (-0.84 to -0.27)), and TNF-alpha concentration (WMD = -0.22 pg/ml, 95% CI (-0.33 to -0.10)).	Curcumin	26-34	cytidine/uridine monophosphate kinase 1	Homo sapiens	79-81
35179079-0	2022	Curcumin suppresses TGF-beta2-induced proliferation, migration, and invasion in lens epithelial cells by targeting KCNQ1OT1/miR-377-3p/COL1A2 axis in posterior capsule opacification.	Curcumin	0-8	transforming growth factor beta 2	Homo sapiens	20-29
35179079-7	2022	RESULTS: Curcumin dose-dependently alleviated transforming growth factor-beta2 (TGF-beta2)-induced proliferation, migration, and invasion in SRA01/04 cells.	Curcumin	9-17	transforming growth factor beta 2	Homo sapiens	46-78
35179079-7	2022	RESULTS: Curcumin dose-dependently alleviated transforming growth factor-beta2 (TGF-beta2)-induced proliferation, migration, and invasion in SRA01/04 cells.	Curcumin	9-17	transforming growth factor beta 2	Homo sapiens	80-89
35179079-9	2022	Curcumin-induced protective effects in TGF-beta2-induced SRA01/04 cells were largely overturned by KCNQ1OT1 overexpression.	Curcumin	0-8	transforming growth factor beta 2	Homo sapiens	39-48
35179079-11	2022	miR-377-3p silencing overturned Curcumin-mediated protective effects in SRA01/04 cells upon TGF-beta2 treatment.	Curcumin	32-40	transforming growth factor beta 2	Homo sapiens	92-101
22986049-9	2013	Furthermore, profound EMT features were observed in LPS-treated rat prostates, and the natural HIF-1alpha inhibitors ascorbate and curcumin were found to attenuate EMT and prostate hyperplasia both in vivo and in vitro.	Curcumin	131-139	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	95-105
23069388-0	2013	Dietary curcumin counteracts extracellular transthyretin deposition: insights on the mechanism of amyloid inhibition.	Curcumin	8-16	transthyretin	Mus musculus	43-56
23069388-2	2013	We have recently shown that curcumin (diferuloylmethane), the major bioactive polyphenol of turmeric, strongly suppresses TTR fibril formation in vitro, either by stabilization of TTR tetramer or by generating nonfibrillar small intermediates that are innocuous to cultured neuronal cells.	Curcumin	28-36	transthyretin	Mus musculus	122-125
23069388-2	2013	We have recently shown that curcumin (diferuloylmethane), the major bioactive polyphenol of turmeric, strongly suppresses TTR fibril formation in vitro, either by stabilization of TTR tetramer or by generating nonfibrillar small intermediates that are innocuous to cultured neuronal cells.	Curcumin	28-36	transthyretin	Mus musculus	180-183
23069388-2	2013	We have recently shown that curcumin (diferuloylmethane), the major bioactive polyphenol of turmeric, strongly suppresses TTR fibril formation in vitro, either by stabilization of TTR tetramer or by generating nonfibrillar small intermediates that are innocuous to cultured neuronal cells.	Curcumin	38-55	transthyretin	Mus musculus	122-125
23069388-2	2013	We have recently shown that curcumin (diferuloylmethane), the major bioactive polyphenol of turmeric, strongly suppresses TTR fibril formation in vitro, either by stabilization of TTR tetramer or by generating nonfibrillar small intermediates that are innocuous to cultured neuronal cells.	Curcumin	38-55	transthyretin	Mus musculus	180-183
35179079-15	2022	CONCLUSION: In conclusion, Curcumin suppressed TGF-beta2-induced malignant changes in lens epithelial cells by targeting KCNQ1OT1/miR-377-3p/COL1A2 axis.	Curcumin	27-35	transforming growth factor beta 2	Homo sapiens	47-56
35122926-5	2022	In vivo, curcumin (50 mg/kg) reduced the accumulation of a-synuclein and led to higher parkinsonian disability scores in 6-OHDA-lesioned PD rats, contributing to induction of autophagy through inhibiting AKT/mTOR signal pathway.	Curcumin	9-17	mechanistic target of rapamycin kinase	Rattus norvegicus	208-212
23069388-3	2013	In the present study, we aim to assess the effect of curcumin on TTR amyloidogenesis in vivo, using a well characterized mouse model for familial amyloidotic polyneuropathy (FAP).	Curcumin	53-61	transthyretin	Mus musculus	65-68
22237476-5	2012	RESULTS: Curcumin and BDMC inhibited LPS-induced barrier permeability, monocyte adhesion and migration; inhibitory effects were significantly correlated with inhibitory functions of curcumin and BDMC on LPS-induced cell adhesion molecules (vascular cell adhesion molecules, intracellular cell adhesion molecule, E-selectin).	Curcumin	182-190	selectin E	Homo sapiens	312-322
23069388-6	2013	We show that curcumin binds selectively to the TTR thyroxine-binding sites of the tetramer over all the other plasma proteins.	Curcumin	13-21	transthyretin	Mus musculus	47-50
23069388-7	2013	The effect on plasma TTR stability was determined by isoelectric focusing (IEF) and curcumin was found to significantly increase TTR tetramer resistance to dissociation.	Curcumin	84-92	transthyretin	Mus musculus	129-132
35122926-7	2022	In conclusion, the present study demonstrated that curcumin repressed PC12 cell death in vitro and improved parkinsonian disability scores in vivo by inhibiting AKT/mTOR signaling pathway which mediated by autophagy, indicating a potential value of curcumin in the therapeutic intervention of Parkinson"s disease.	Curcumin	51-59	mechanistic target of rapamycin kinase	Rattus norvegicus	165-169
35122926-7	2022	In conclusion, the present study demonstrated that curcumin repressed PC12 cell death in vitro and improved parkinsonian disability scores in vivo by inhibiting AKT/mTOR signaling pathway which mediated by autophagy, indicating a potential value of curcumin in the therapeutic intervention of Parkinson"s disease.	Curcumin	249-257	mechanistic target of rapamycin kinase	Rattus norvegicus	165-169
35559378-7	2022	RESULTS: Network pharmacology suggested that curcumin treated EM through the HIF signaling pathway, of which IL-6, HIF-1alpha, and VEGFA are key targets.	Curcumin	45-53	vascular endothelial growth factor A	Mus musculus	131-136
23069388-8	2013	Most importantly, immunohistochemistry (IHC) analysis of mice tissues demonstrated that curcumin reduced TTR load in as much as 70% and lowered cytotoxicity associated with TTR aggregation by decreasing activation of death receptor Fas/CD95, endoplasmic reticulum (ER) chaperone BiP and 3-nitrotyrosine in tissues.	Curcumin	88-96	transthyretin	Mus musculus	105-108
23069388-8	2013	Most importantly, immunohistochemistry (IHC) analysis of mice tissues demonstrated that curcumin reduced TTR load in as much as 70% and lowered cytotoxicity associated with TTR aggregation by decreasing activation of death receptor Fas/CD95, endoplasmic reticulum (ER) chaperone BiP and 3-nitrotyrosine in tissues.	Curcumin	88-96	transthyretin	Mus musculus	173-176
22366174-1	2012	Curcumin influences the transition point, the concentration of denaturant required to effect 50% of the total change, of myoglobin denaturation.	Curcumin	0-8	myoglobin	Homo sapiens	121-130
23069388-9	2013	Taken together, our results highlight the potential use of curcumin as a lead molecule for the prevention and treatment of TTR amyloidosis.	Curcumin	59-67	transthyretin	Mus musculus	123-126
24335167-0	2013	Dietary curcumin ameliorates aging-related cerebrovascular dysfunction through the AMPK/uncoupling protein 2 pathway.	Curcumin	8-16	uncoupling protein 2	Rattus norvegicus	88-108
24335167-5	2013	In this study, we tested the hypothesis that dietary curcumin, which has an antioxidant effect, can improve aging-related cerebrovascular dysfunction via UCP2 up-regulation.	Curcumin	53-61	uncoupling protein 2	Rattus norvegicus	154-158
24335167-11	2013	In cerebral arteries from aging SD rats and cultured endothelial cells, curcumin promoted eNOS and AMPK phosphorylation, up-regulated UCP2 and reduced ROS production.	Curcumin	72-80	uncoupling protein 2	Rattus norvegicus	134-138
24335167-12	2013	These effects of curcumin were abolished by either AMPK or UCP2 inhibition.	Curcumin	17-25	uncoupling protein 2	Rattus norvegicus	59-63
24335167-14	2013	CONCLUSIONS: Curcumin improves aging-related cerebrovascular dysfunction via the AMPK/UCP2 pathway.	Curcumin	13-21	uncoupling protein 2	Rattus norvegicus	86-90
35458704-7	2022	Although LPS increased AhR and its target gene CYP1B1, curcumin further enhanced LPS-induced CYP1B1 and indoleamine 2,3-dioxygenase (IDO), which metabolizes tryptophan to AhR ligands kynurenine (KYN) and kynurenic acid (KYNA).	Curcumin	55-63	aryl hydrocarbon receptor	Rattus norvegicus	23-26
22366174-2	2012	Curcumin enhances absorbance of myoglobin at 280 nm with a binding constant K=3.0x10(4) M(-1) whereas fluorescence of curcumin is quenched by myoglobin with a Stern-Volmer association constant of 2.5x10(5) M(-1).	Curcumin	0-8	myoglobin	Homo sapiens	32-41
22366174-2	2012	Curcumin enhances absorbance of myoglobin at 280 nm with a binding constant K=3.0x10(4) M(-1) whereas fluorescence of curcumin is quenched by myoglobin with a Stern-Volmer association constant of 2.5x10(5) M(-1).	Curcumin	118-126	myoglobin	Homo sapiens	142-151
22366174-3	2012	Unfolding process of myoglobin-curcumin induces a recovery in fluorescence lifetime loss.	Curcumin	31-39	myoglobin	Homo sapiens	21-30
23762140-0	2013	Curcumin Protects Neuron against Cerebral Ischemia-Induced Inflammation through Improving PPAR-Gamma Function.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	90-100
22366174-4	2012	The gain in time-resolved fluorescence lifetime during unfolding has been again lost during refolding of curcumin-myoglobin complex by dilution process suggesting partial reversibility of unfolding process for both myoglobin and curcumin-myoglobin complex.	Curcumin	105-113	myoglobin	Homo sapiens	114-123
23762140-4	2013	In the present study, using rat middle cerebral artery occlusion model, we found that curcumin was a potent PPAR gamma agonist in that it upregulated PPAR gamma expression and PPAR gamma -PPRE binding activity.	Curcumin	86-94	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	108-118
22366174-4	2012	The gain in time-resolved fluorescence lifetime during unfolding has been again lost during refolding of curcumin-myoglobin complex by dilution process suggesting partial reversibility of unfolding process for both myoglobin and curcumin-myoglobin complex.	Curcumin	105-113	myoglobin	Homo sapiens	215-224
23762140-4	2013	In the present study, using rat middle cerebral artery occlusion model, we found that curcumin was a potent PPAR gamma agonist in that it upregulated PPAR gamma expression and PPAR gamma -PPRE binding activity.	Curcumin	86-94	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	150-160
23762140-4	2013	In the present study, using rat middle cerebral artery occlusion model, we found that curcumin was a potent PPAR gamma agonist in that it upregulated PPAR gamma expression and PPAR gamma -PPRE binding activity.	Curcumin	86-94	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	150-160
22366174-4	2012	The gain in time-resolved fluorescence lifetime during unfolding has been again lost during refolding of curcumin-myoglobin complex by dilution process suggesting partial reversibility of unfolding process for both myoglobin and curcumin-myoglobin complex.	Curcumin	105-113	myoglobin	Homo sapiens	215-224
24454990-4	2013	Pretreatment of CGNs with 5-30 muM curcumin effectively increased by 2.3-4.9 fold heme oxygenase-1 (HO-1) expression and by 5.6-14.3-fold glutathione (GSH) levels.	Curcumin	35-43	heme oxygenase 1	Rattus norvegicus	82-98
22366174-4	2012	The gain in time-resolved fluorescence lifetime during unfolding has been again lost during refolding of curcumin-myoglobin complex by dilution process suggesting partial reversibility of unfolding process for both myoglobin and curcumin-myoglobin complex.	Curcumin	229-237	myoglobin	Homo sapiens	114-123
24454990-7	2013	These data strongly suggest that HO-1 and GSH play a major role in the protective effect of curcumin.	Curcumin	92-100	heme oxygenase 1	Rattus norvegicus	33-45
21324484-10	2012	Curcumin had effective inhibitory effects on the expression of TLR4, MyD88, and NF-kappaB in lung tissues 24 h post-CPB (P &lt; 0.05 versus vehicle group).	Curcumin	0-8	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	69-74
23183190-0	2013	Inhibition effect of curcumin on TNF-alpha and MMP-13 expression induced by advanced glycation end products in chondrocytes.	Curcumin	21-29	collagenase 3	Oryctolagus cuniculus	47-53
23183190-2	2013	In the present study, we examined the effect of curcumin, a pharmacologically safe phytochemical agent, on AGE-induced tumor necrosis factor-alpha (TNF-alpha) and matrix metalloproteinase-13 (MMP-13) in rabbit chondrocytes.	Curcumin	48-56	collagenase 3	Oryctolagus cuniculus	163-190
23183190-8	2013	RESULTS: Curcumin significantly decreased AGE-stimulated TNF-alpha and MMP-13 mRNA and suppressed the NF-kB activation via inhibition of kBalpha (I-kBalpha) phosphorylation, I-kBalpha degradation and p65 nuclear translocation.	Curcumin	9-17	collagenase 3	Oryctolagus cuniculus	71-77
23457487-4	2013	Here we show that curcumin down-regulates DNMT1 expression in AML cell lines, both in vitro and in vivo, and in primary AML cells ex vivo.	Curcumin	18-26	DNA methyltransferase 1	Homo sapiens	42-47
23457487-5	2013	Mechanistically, curcumin reduced the expression of positive regulators of DNMT1, p65 and Sp1, which correlated with a reduction in binding of these transcription factors to the DNMT1 promoter in AML cell lines.	Curcumin	17-25	DNA methyltransferase 1	Homo sapiens	75-80
23457487-5	2013	Mechanistically, curcumin reduced the expression of positive regulators of DNMT1, p65 and Sp1, which correlated with a reduction in binding of these transcription factors to the DNMT1 promoter in AML cell lines.	Curcumin	17-25	DNA methyltransferase 1	Homo sapiens	178-183
23457487-6	2013	This curcumin-mediated down-regulation of DNMT1 expression was concomitant with p15(INK4B) tumor suppressor gene reactivation, hypomethylation of the p15(INK4B) promoter, G1 cell cycle arrest, and induction of tumor cell apoptosis in vitro.	Curcumin	5-13	DNA methyltransferase 1	Homo sapiens	42-47
21324484-13	2012	This anti-inflammatory effect of curcumin is partly related to the inhibition of TLR4, MyD88, and NF-kappaB.	Curcumin	33-41	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	87-92
22883304-1	2012	In this study, curcumin derivatives salicylidenecurcumin (CD1) and benzalidenecurcumin (CD2)] were prepared, and their biological activity was compared in in vitro selenite-induced cataract model.	Curcumin	15-23	Cd2 molecule	Rattus norvegicus	88-91
22475209-5	2012	RESULTS: KI mice fed a curcumin-containing diet since conception showed decreased huntingtin aggregates and increased striatal DARPP-32 and D1 receptor mRNAs, as well as an amelioration of rearing deficits.	Curcumin	23-31	huntingtin	Mus musculus	82-92
22883304-6	2012	These results indicated that curcumin and its derivatives--CD1 and CD2--are beneficial against selenite-induced cataract in vitro.	Curcumin	29-37	Cd2 molecule	Rattus norvegicus	67-70
21801469-0	2012	Food additives such as sodium sulphite, sodium benzoate and curcumin inhibit leptin release in lipopolysaccharide-treated murine adipocytes in vitro.	Curcumin	60-68	leptin	Mus musculus	77-83
23058916-0	2012	Inhibition of Ca(2+) release-activated Ca(2+) channel (CRAC) by curcumin and caffeic acid phenethyl ester (CAPE) via electrophilic addition to a cysteine residue of Orai1.	Curcumin	64-72	ORAI calcium release-activated calcium modulator 1	Homo sapiens	165-170
23058916-3	2012	We previously observed that curcumin and caffeic acid phenethyl ester (CAPE) inhibit CRAC current in Orai1/STIM1-co-expressing HEK293 cells (Nam et al., 2009; Shin et al., 2011) [1,2].	Curcumin	28-36	ORAI calcium release-activated calcium modulator 1	Homo sapiens	101-106
22252298-10	2012	Together, CoQ10, selenite, and curcumin act as inhibitors of RANKL-induced NFATc1 which is a downstream event of NF-kappaB signal pathway through suppression of ROS generation, thereby suggesting their potential usefulness for the treatment of bone disease associated with excessive bone resorption.	Curcumin	31-39	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	61-66
22038833-2	2012	This is associated with increased colocalization of CFTR and K18 in the vicinity of the endoplasmic reticulum, although this is reversed by treating cells with curcumin, resulting in the rescue of F508del-CFTR.	Curcumin	160-168	keratin 18	Homo sapiens	61-64
22776359-4	2012	RESULTS: There were significant increases in the levels of cell density, gamma-IFN, and CD8, accompanied with significant decrease in the level of CD4, when comparing cultured cells treated with curcumin and taurine with control cultured cells.	Curcumin	195-203	CD8a molecule	Homo sapiens	88-91
22776359-6	2012	Moreover, curcumin/taurine combined therapy enhances immunity by stimulating the CD4(+) T-helper cells with consequent induction of CD8 T-cell responses to lyse tumor cells.	Curcumin	10-18	CD8a molecule	Homo sapiens	132-135
21945716-6	2012	The anti-allodynic action of curcumin on mechanical stimuli was totally blocked by chronic co-treatment with the beta(2)-adrenoceptor antagonist ICI 118,551, or by acute co-treatment with the delta-opioid receptor antagonist naltrindole.	Curcumin	29-37	adrenergic receptor, beta 2	Mus musculus	113-133
22402368-0	2012	Differential regulation of CD4(+) T helper cell responses by curcumin in experimental autoimmune encephalomyelitis.	Curcumin	61-69	CD4 antigen	Mus musculus	27-30
22402368-5	2012	In this study, we show that C57BL/6 mice induced to develop EAE express elevated levels of interferon (IFN) gamma and interleukin (IL)-17 in the central nervous system (CNS) and lymphoid organs that decreased significantly following in vivo treatment with curcumin.	Curcumin	256-264	interleukin 17A	Mus musculus	118-137
22733496-9	2012	Similarly the increased SOD2, GPx1 and decreased CAT activities in MF were also normalized by vitamin E and curcumin supplementation.	Curcumin	108-116	superoxide dismutase 2	Rattus norvegicus	24-28
23095512-16	2012	The curcumin-surviving lines showed a significant loss in the high staining ALDH1A1 and CD44 cell populations.	Curcumin	4-12	CD44 molecule (Indian blood group)	Homo sapiens	88-92
21945716-8	2012	Collectively, these findings indicate that the descending monoamine system (coupled with spinal beta(2)-adrenoceptor and 5-HT(1A) receptor) is critical for the modality-specific antinociceptive effect of curcumin in neuropathic pain.	Curcumin	204-212	adrenergic receptor, beta 2	Mus musculus	96-116
23442673-3	2012	Moreover, curcumin regulated urate transport-related proteins and inhibited activation of the JAK2-STAT3 cascade and overexpression of SOCS3 and TGF-beta1 in the kidneys of fructose-fed rats.	Curcumin	10-18	Janus kinase 2	Rattus norvegicus	94-98
23442673-4	2012	These results suggested that the anti-hyperuricaemic and renal protective actions of curcumin might be the result of renal NO-mediated JAK2-STAT3 signalling and TGF-beta1 normality, which ameliorated renal endothelial dysfunction to improve renal urate transporter system in this model.	Curcumin	85-93	Janus kinase 2	Rattus norvegicus	135-139
22005927-0	2012	Curcumin inhibits ox-LDL-induced MCP-1 expression by suppressing the p38MAPK and NF-kappaB pathways in rat vascular smooth muscle cells.	Curcumin	0-8	C-C motif chemokine ligand 2	Rattus norvegicus	33-38
23259320-0	2012	Curcumin delays endometriosis development by inhibiting MMP-2 activity.	Curcumin	0-8	matrix metallopeptidase 2	Mus musculus	56-61
22005927-1	2012	OBJECTIVE: This study was designed to identify the inhibitory effect of curcumin on ox-LDL-induced monocyte chemoattractant protein-1 (MCP-1) production and investigated whether the effects are mediated by mitogen-activated protein kinase (MAPK) and NF-kappaB pathways in rat vascular smooth muscle cells (VSMCs).	Curcumin	72-80	C-C motif chemokine ligand 2	Rattus norvegicus	99-133
23259320-10	2012	In addition, curcumin inhibited production of active MMP-2 by down-regulating MT1MMP expression.	Curcumin	13-21	matrix metallopeptidase 2	Mus musculus	53-58
23259320-10	2012	In addition, curcumin inhibited production of active MMP-2 by down-regulating MT1MMP expression.	Curcumin	13-21	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	78-84
22005927-1	2012	OBJECTIVE: This study was designed to identify the inhibitory effect of curcumin on ox-LDL-induced monocyte chemoattractant protein-1 (MCP-1) production and investigated whether the effects are mediated by mitogen-activated protein kinase (MAPK) and NF-kappaB pathways in rat vascular smooth muscle cells (VSMCs).	Curcumin	72-80	C-C motif chemokine ligand 2	Rattus norvegicus	135-140
23259320-11	2012	Moreover, endometriotic progression was directly linked with increased MMP-2/TIMP-2 ratio which was delayed by curcumin pretreatment.	Curcumin	111-119	matrix metallopeptidase 2	Mus musculus	71-76
22005927-6	2012	Additionally, curcumin decreased the expression of MCP-1 in a dose-dependent manner under treatment with ox-LDL (100 mug/ml).	Curcumin	14-22	C-C motif chemokine ligand 2	Rattus norvegicus	51-56
22921746-4	2012	In this study, we investigated the inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion and the molecular mechanisms involved in MCF-7 cells.	Curcumin	56-64	matrix metallopeptidase 9	Homo sapiens	119-124
22539869-0	2012	Curcumin protects retinal pigment epithelial cells against oxidative stress via induction of heme oxygenase-1 expression and reduction of reactive oxygen.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	93-109
22921746-5	2012	Our results showed that curcumin inhibits TPA-induced MMP-9 expression and cell invasion through suppressing NF-kappaB and AP-1 activation.	Curcumin	24-32	matrix metallopeptidase 9	Homo sapiens	54-59
22921746-7	2012	These results indicate that curcumin-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the PKCalpha, MAPK and NF-kappaB/AP-1 pathway in MCF-7 cells.	Curcumin	28-36	matrix metallopeptidase 9	Homo sapiens	72-77
22705585-0	2012	Beneficial effects of curcumin on GFAP filament organization and down-regulation of GFAP expression in an in vitro model of Alexander disease.	Curcumin	22-30	glial fibrillary acidic protein	Homo sapiens	34-38
22705585-0	2012	Beneficial effects of curcumin on GFAP filament organization and down-regulation of GFAP expression in an in vitro model of Alexander disease.	Curcumin	22-30	glial fibrillary acidic protein	Homo sapiens	84-88
22705585-5	2012	In particular, depending on the dose used, we have observed that curcumin is able to induce both HSP27 and alphaB-crystallin, to reduce expression of both RNA and protein of endogenous GFAP, to induce autophagy and, finally, to rescue the filamentous organization of the GFAP mutant protein, thus suggesting a role of this spice in counteracting the pathogenic effects of GFAP mutations.	Curcumin	65-73	glial fibrillary acidic protein	Homo sapiens	185-189
22749847-0	2012	Curcumin inhibits suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro.	Curcumin	0-8	CD4 antigen	Mus musculus	62-65
22749847-0	2012	Curcumin inhibits suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro.	Curcumin	0-8	interleukin 2 receptor, alpha chain	Mus musculus	66-70
22749847-4	2012	In the present study, curcumin inhibition of the suppressive activity of CD4(+)CD25(+) regulatory T cells appears to be dependent on three categories: inhibiting cell-cell contact by down-regulation of CTLA-4, suppressing inhibitory cytokine secretion and decreasing the ability to consume IL-2 and/or suppress IL-2 production.	Curcumin	22-30	CD4 antigen	Mus musculus	73-76
22539869-1	2012	PURPOSE: To determine whether curcumin induces expression of the defensive enzyme heme oxygenase-1 (HO-1) and protects cells against oxidative stress in cultured human retinal pigment epithelial cells.	Curcumin	30-38	heme oxygenase 1	Homo sapiens	82-98
22539869-1	2012	PURPOSE: To determine whether curcumin induces expression of the defensive enzyme heme oxygenase-1 (HO-1) and protects cells against oxidative stress in cultured human retinal pigment epithelial cells.	Curcumin	30-38	heme oxygenase 1	Homo sapiens	100-104
22539869-5	2012	To confirm the protective role of HO-1 in oxidative stress, small interfering RNA (siRNA) against HO-1 or inhibitor of HO-1 was treated with curcumin in retinal pigment epithelium cells.	Curcumin	141-149	heme oxygenase 1	Homo sapiens	98-123
22539869-10	2012	Curcumin"s effect on the reduction of ROS was mediated by the increase in HO-1 expression.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	74-78
22749847-4	2012	In the present study, curcumin inhibition of the suppressive activity of CD4(+)CD25(+) regulatory T cells appears to be dependent on three categories: inhibiting cell-cell contact by down-regulation of CTLA-4, suppressing inhibitory cytokine secretion and decreasing the ability to consume IL-2 and/or suppress IL-2 production.	Curcumin	22-30	interleukin 2 receptor, alpha chain	Mus musculus	79-83
22539869-11	2012	CONCLUSIONS: Curcumin upregulated the oxidative stress defense enzyme HO-1 and may protect human retinal pigment epithelial cells against oxidative stress by reducing ROS levels.	Curcumin	13-21	heme oxygenase 1	Homo sapiens	70-74
22749847-4	2012	In the present study, curcumin inhibition of the suppressive activity of CD4(+)CD25(+) regulatory T cells appears to be dependent on three categories: inhibiting cell-cell contact by down-regulation of CTLA-4, suppressing inhibitory cytokine secretion and decreasing the ability to consume IL-2 and/or suppress IL-2 production.	Curcumin	22-30	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	202-208
22749847-6	2012	Moreover, we found that nuclear translocation of p65 and c-Rel, which is critical for Foxp3 and CD25 expressions, was markedly decreased in Tregs with curcumin stimulation.	Curcumin	151-159	interleukin 2 receptor, alpha chain	Mus musculus	96-100
22876123-8	2012	In addition, mice administered curcumin had less interleukin-4 (IL-4) and interleukin-5 (IL-5) (Th2 type cytokine) production in conjunctiva, spleen, and cervical lymph nodes than mice in the non-curcumin-administered group.	Curcumin	31-39	interleukin 4	Mus musculus	49-62
22653966-4	2012	Curcumin also downregulates the expression of antiapoptotic proteins c-FLIP, Bcl-xL, cellular inhibitor of apoptosis protein, and X-linked IAP in a ROS-dependent manner.	Curcumin	0-8	X-linked inhibitor of apoptosis	Homo sapiens	130-142
22653966-5	2012	Curcumin disrupts the integrity of IKK and beclin-1 by degrading Hsp90.	Curcumin	0-8	beclin 1	Homo sapiens	43-51
22876123-8	2012	In addition, mice administered curcumin had less interleukin-4 (IL-4) and interleukin-5 (IL-5) (Th2 type cytokine) production in conjunctiva, spleen, and cervical lymph nodes than mice in the non-curcumin-administered group.	Curcumin	31-39	interleukin 4	Mus musculus	64-68
22653966-7	2012	Degradation of beclin-1 by curcumin leads to the accumulation of autophagy-specific marker, microtubule-associated protein-I light chain 3 (LC3), LC3-I.	Curcumin	27-35	beclin 1	Homo sapiens	15-23
22876123-8	2012	In addition, mice administered curcumin had less interleukin-4 (IL-4) and interleukin-5 (IL-5) (Th2 type cytokine) production in conjunctiva, spleen, and cervical lymph nodes than mice in the non-curcumin-administered group.	Curcumin	31-39	interleukin 5	Mus musculus	74-87
22876123-8	2012	In addition, mice administered curcumin had less interleukin-4 (IL-4) and interleukin-5 (IL-5) (Th2 type cytokine) production in conjunctiva, spleen, and cervical lymph nodes than mice in the non-curcumin-administered group.	Curcumin	31-39	interleukin 5	Mus musculus	89-93
21964250-6	2012	In particular, we tested 17-AAG, ibuprofen, 4-PBA, curcumin, trehalose, congo red and chrysamine G for their ability to i) recover the nuclear localisation of polyAla expanded PHOX2B, ii) rescue of PHOX2B mediated transactivation of the DBH promoter, and iii) clearance of PHOX2B (+13 Ala) aggregates.	Curcumin	51-59	dopamine beta-hydroxylase	Homo sapiens	237-240
22076484-4	2012	The decreased translated products (SOD1 and SOD2) and the unchanged activity of SOD in cerebral cortex of PTU-treated rats were increased on supplementation of curcumin to the hypothyroid rats.	Curcumin	160-168	superoxide dismutase 2	Rattus norvegicus	44-48
22076484-5	2012	Declined translated products of SOD1 and SOD2 in cerebellum of PTU-treated rats were alleviated on administration of curcumin to hypothyroid rats.	Curcumin	117-125	superoxide dismutase 2	Rattus norvegicus	41-45
22634334-6	2012	Our previous work has demonstrated the way by which curcumin interacts with recombinant TrxR1 and alters the antioxidant enzyme into a reactive oxygen species (ROS) generator in vitro.	Curcumin	52-60	thioredoxin reductase 1	Homo sapiens	88-93
22634334-8	2012	Curcumin-modified TrxR1 dose-dependently and quantitatively transfers electrons from NADPH to oxygen with the production of ROS.	Curcumin	0-8	thioredoxin reductase 1	Homo sapiens	18-23
22634334-11	2012	Knockdown of TrxR1 sensitizes HeLa cells to curcumin cytotoxicity, highlighting the physiological significance of targeting TrxR1 by curcumin.	Curcumin	44-52	thioredoxin reductase 1	Homo sapiens	13-18
22634334-11	2012	Knockdown of TrxR1 sensitizes HeLa cells to curcumin cytotoxicity, highlighting the physiological significance of targeting TrxR1 by curcumin.	Curcumin	133-141	thioredoxin reductase 1	Homo sapiens	13-18
22634334-11	2012	Knockdown of TrxR1 sensitizes HeLa cells to curcumin cytotoxicity, highlighting the physiological significance of targeting TrxR1 by curcumin.	Curcumin	133-141	thioredoxin reductase 1	Homo sapiens	124-129
22762693-2	2012	Curcumin has been identified as a potent inducer of heme-oxygenase-1 (HO-1), a redoxsensitive inducible protein that provides protection against various forms of stress.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	52-68
22762693-2	2012	Curcumin has been identified as a potent inducer of heme-oxygenase-1 (HO-1), a redoxsensitive inducible protein that provides protection against various forms of stress.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	70-74
22997831-1	2012	OBJECTIVE: To observe the effect of curcumin on the expression of synapse-related proteins PSD-95 and Shank1 in APP/PS1 double transgenic mice.	Curcumin	36-44	discs large MAGUK scaffold protein 4	Mus musculus	91-97
22997831-1	2012	OBJECTIVE: To observe the effect of curcumin on the expression of synapse-related proteins PSD-95 and Shank1 in APP/PS1 double transgenic mice.	Curcumin	36-44	SH3 and multiple ankyrin repeat domains 1	Mus musculus	102-108
22997831-5	2012	The expression of PSD-95 and Shank1-positive cells of hippocampus CA1 region significantly decreased in model mice compared with normal control group (P &lt; 0.01); while the curcumin intervention group showed recovery to some extend.	Curcumin	175-183	discs large MAGUK scaffold protein 4	Mus musculus	18-24
22997831-5	2012	The expression of PSD-95 and Shank1-positive cells of hippocampus CA1 region significantly decreased in model mice compared with normal control group (P &lt; 0.01); while the curcumin intervention group showed recovery to some extend.	Curcumin	175-183	SH3 and multiple ankyrin repeat domains 1	Mus musculus	29-35
22997831-6	2012	Western blot results showed that the strap of PSD-95 protein expression became significantly thinner and lighter in the model group compared with the normal control group (P &lt; 0.01); while the curcumin intervention group showed notably thicker and darker straps of PSD-95 protein expression (P &lt; 0.05).	Curcumin	196-204	discs large MAGUK scaffold protein 4	Mus musculus	46-52
22997831-6	2012	Western blot results showed that the strap of PSD-95 protein expression became significantly thinner and lighter in the model group compared with the normal control group (P &lt; 0.01); while the curcumin intervention group showed notably thicker and darker straps of PSD-95 protein expression (P &lt; 0.05).	Curcumin	196-204	discs large MAGUK scaffold protein 4	Mus musculus	268-274
22997831-7	2012	CONCLUSION: Curcumin can increase the expression of synapse-related proteins PSD95 and Shank1 in APP/PS1 double transgenic mice, improve structure and plasticity of synapse in APP/PS1 double transgenic mice and enhance their learning and memory abilities.	Curcumin	12-20	discs large MAGUK scaffold protein 4	Mus musculus	77-82
22997831-7	2012	CONCLUSION: Curcumin can increase the expression of synapse-related proteins PSD95 and Shank1 in APP/PS1 double transgenic mice, improve structure and plasticity of synapse in APP/PS1 double transgenic mice and enhance their learning and memory abilities.	Curcumin	12-20	SH3 and multiple ankyrin repeat domains 1	Mus musculus	87-93
22387197-6	2012	Curcumin suppresses the growth of human leukemic cells via ROS-independent GSH depletion, which leads to caspase activation, inhibition of sphingomyelin synthase (SMS) activity, and induction of ceramide (Cer) generation.	Curcumin	0-8	spermine synthase	Homo sapiens	139-161
22387197-6	2012	Curcumin suppresses the growth of human leukemic cells via ROS-independent GSH depletion, which leads to caspase activation, inhibition of sphingomyelin synthase (SMS) activity, and induction of ceramide (Cer) generation.	Curcumin	0-8	spermine synthase	Homo sapiens	163-166
22387197-10	2012	Taken together, our findings provide evidence suggesting for the first time that GSH regulates caspase-dependent inhibition of SMS activity, Cer generation, and apoptosis induced by curcumin in human leukemic cells.	Curcumin	182-190	spermine synthase	Homo sapiens	127-130
22648616-6	2012	Furthermore, the curcumin-induced upregulation of ABCA1 was mainly through calmodulin-liver X receptor alpha (LXRalpha)-dependent transcriptional regulation.	Curcumin	17-25	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	50-55
22648616-7	2012	Curcumin administration modulated the expression of SR-A, ABCA1, ABCG1, and SR-BI in aortas and retarded atherosclerosis in apoE-/- mice.	Curcumin	0-8	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	58-63
22648616-8	2012	CONCLUSION: Our findings suggest that inhibition of SR-A-mediated oxLDL uptake and promotion of ABCA1-dependent cholesterol efflux are two crucial events in suppression of cholesterol accumulation by curcumin in the transformation of macrophage foam cells.	Curcumin	200-208	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	96-101
22298641-6	2012	Similarly, expression of dominant negative c-Jun or downregulation of Erk1/2 in part attenuated curcumin-induced cell death.	Curcumin	96-104	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	43-48
22443687-11	2012	CONCLUSIONS: This study demonstrates that curcumin can induce the THP-1 cell apoptosis through the activation of JNK/ERK/AP1 pathways.	Curcumin	42-50	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	121-124
22568037-0	2012	Identification of curcumin targets in neuroinflammatory pathways: molecular docking scores with GSK-3beta, p38 MAPK, COX, ICE and TACE enzymes.	Curcumin	18-26	ADAM metallopeptidase domain 17	Homo sapiens	130-134
22568037-2	2012	The anti-inflammatory pathway of curcumin was identified through docking with of curcumin with various inflammation inducing enzymes like glycogen synthase kinase (GSK-3beta), p38 mitogen activated protein kinase (MAPK), COX, interleukin-1beta converting enzyme (ICE) and tumor necrosis factor-alpha converting enzyme (TACE).	Curcumin	33-41	ADAM metallopeptidase domain 17	Homo sapiens	272-317
22568037-2	2012	The anti-inflammatory pathway of curcumin was identified through docking with of curcumin with various inflammation inducing enzymes like glycogen synthase kinase (GSK-3beta), p38 mitogen activated protein kinase (MAPK), COX, interleukin-1beta converting enzyme (ICE) and tumor necrosis factor-alpha converting enzyme (TACE).	Curcumin	33-41	ADAM metallopeptidase domain 17	Homo sapiens	319-323
22568037-2	2012	The anti-inflammatory pathway of curcumin was identified through docking with of curcumin with various inflammation inducing enzymes like glycogen synthase kinase (GSK-3beta), p38 mitogen activated protein kinase (MAPK), COX, interleukin-1beta converting enzyme (ICE) and tumor necrosis factor-alpha converting enzyme (TACE).	Curcumin	81-89	ADAM metallopeptidase domain 17	Homo sapiens	272-317
22568037-2	2012	The anti-inflammatory pathway of curcumin was identified through docking with of curcumin with various inflammation inducing enzymes like glycogen synthase kinase (GSK-3beta), p38 mitogen activated protein kinase (MAPK), COX, interleukin-1beta converting enzyme (ICE) and tumor necrosis factor-alpha converting enzyme (TACE).	Curcumin	81-89	ADAM metallopeptidase domain 17	Homo sapiens	319-323
22568037-5	2012	The binding target GSK-3beta (-6.44) was found to be more selective for curcumin binding when compared with MAPK (-4.08), COX (-7.35), ICE (-4.02), TACE (-6.38) and their respective native ligand.	Curcumin	72-80	ADAM metallopeptidase domain 17	Homo sapiens	148-152
22021079-5	2012	Curcumin increased FOXO3a-mediated gene expression by twofold (P &lt; 0.05), possibly as a result of influencing FOXO3a phosphorylation and nuclear translocation.	Curcumin	0-8	forkhead box O3	Mus musculus	19-25
22021079-5	2012	Curcumin increased FOXO3a-mediated gene expression by twofold (P &lt; 0.05), possibly as a result of influencing FOXO3a phosphorylation and nuclear translocation.	Curcumin	0-8	forkhead box O3	Mus musculus	113-119
22021079-7	2012	In contrast to the in vitro results, curcumin showed a trend for reduction of lipid levels in peritoneal macrophages in LDL receptor knockout mice fed a high fat diet for 4 months, suggesting additional regulatory mechanisms in vivo.	Curcumin	37-45	low density lipoprotein receptor	Mus musculus	120-132
22021079-8	2012	Thus, the up-regulation of FOXO3a activity by curcumin could be a mechanism to protect against oxidant- and lipid-induced damage in the inflammatory cells of the vascular system.	Curcumin	46-54	forkhead box O3	Mus musculus	27-33
21986891-5	2012	In conclusion, curcumin, alpha-lipoic acid, and N-acetylcysteine protect rats against CCl(4)-induced liver fibrosis most possibly through their antioxidant activities and their capacities to induce MMP-13 and to inhibit TGF-alpha levels.	Curcumin	15-23	matrix metallopeptidase 13	Rattus norvegicus	198-204
21986891-5	2012	In conclusion, curcumin, alpha-lipoic acid, and N-acetylcysteine protect rats against CCl(4)-induced liver fibrosis most possibly through their antioxidant activities and their capacities to induce MMP-13 and to inhibit TGF-alpha levels.	Curcumin	15-23	transforming growth factor alpha	Rattus norvegicus	220-229
22174410-6	2012	Nfe2 modulates JunD binding to the Gcm1 promoter via acetylation, as reducing JunD acetylation using the histone acetyltransferase inhibitor curcumin reverses the increased JunD DNA-binding activity observed in the absence of Nfe2.	Curcumin	141-149	glial cells missing transcription factor 1	Homo sapiens	35-39
21780253-8	2012	These results suggest that curcumin and catechin in combination can inhibit the proliferation of HCT 15, HCT 116, as well as Hep G-2 cells efficiently through induction of apoptosis.	Curcumin	27-35	DNL-type zinc finger	Homo sapiens	125-128
22512082-0	2012	Effects of curcumin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen, in rats: possible role of CYP3A4 and P-glycoprotein inhibition by curcumin.	Curcumin	170-178	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	141-155
22512082-2	2012	Tamoxifen and curcumin interact with cytochrom P450 (CYP) enzymes and P-glycoprotein, and the increase in the use of health supplements may result in curcumin being taken concomitantly with tamoxifen as a combination therapy to treat or prevent cancer.	Curcumin	14-22	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	70-84
22512082-7	2012	This result suggested that curcumin significantly inhibited P-gp activity.	Curcumin	27-35	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	60-64
22512082-12	2012	The enhanced bioavailability of tamoxifen by curcumin may be mainly due to inhibition of the CYP3A4-mediated metabolism of tamoxifen in the small intestine and/or in the liver and to inhibition of the P-gp efflux transporter in the small intestine rather than to reduction of renal elimination of tamoxifen, suggesting that curcumin may reduce the first-pass metabolism of tamoxifen in the small intestine and/or in the liver by inhibition of P-gp or CYP3A4 subfamily.	Curcumin	45-53	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	201-205
22512082-12	2012	The enhanced bioavailability of tamoxifen by curcumin may be mainly due to inhibition of the CYP3A4-mediated metabolism of tamoxifen in the small intestine and/or in the liver and to inhibition of the P-gp efflux transporter in the small intestine rather than to reduction of renal elimination of tamoxifen, suggesting that curcumin may reduce the first-pass metabolism of tamoxifen in the small intestine and/or in the liver by inhibition of P-gp or CYP3A4 subfamily.	Curcumin	45-53	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	443-447
22512082-12	2012	The enhanced bioavailability of tamoxifen by curcumin may be mainly due to inhibition of the CYP3A4-mediated metabolism of tamoxifen in the small intestine and/or in the liver and to inhibition of the P-gp efflux transporter in the small intestine rather than to reduction of renal elimination of tamoxifen, suggesting that curcumin may reduce the first-pass metabolism of tamoxifen in the small intestine and/or in the liver by inhibition of P-gp or CYP3A4 subfamily.	Curcumin	324-332	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	201-205
22253518-6	2012	The nude mouse xenograft assay showed that EGCG and the combinations of curcumin, EGCG and lovastatin suppressed esophageal cancer cell growth and reduced the expression of Ki67, phosphorylated Erk1/2 and COX-2.	Curcumin	72-80	antigen identified by monoclonal antibody Ki 67	Mus musculus	173-177
22830350-3	2012	Because the C-11/ C-12 diketonic moiety of the tetracyclines is primarily responsible, through zinc-binding, for MMP inhibition, we have uniquely modified curcumin as a "core" molecule, since it contains a similar enolic system and is known to have beneficial effects in diseases where connective-tissue loss occurs.	Curcumin	155-163	RNA polymerase III subunit K	Homo sapiens	12-16
22830351-4	2012	CMC 2.24 binds more strongly to BSA than curcumin, with a dissociation constant of 0.56+-0.08 muM compared to 1.32+-0.17 muM.	Curcumin	41-49	C-X9-C motif containing 2	Homo sapiens	0-5
22927762-8	2012	Most importantly, curcumin-loaded CSO-SA micelles were effective for inhibiting subpopulations of CD44(+)/CD24(+) cells (putative colorectal cancer stem cell markers) both in vitro and in vivo.	Curcumin	18-26	CD44 antigen	Mus musculus	98-102
22942754-5	2012	Western blot analyses showed that curcumin decreased the ionomycin-induced phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and synaptic vesicle-associated protein synapsin I, the main presynaptic target of ERK.	Curcumin	34-42	synapsin I	Rattus norvegicus	189-199
22426019-0	2012	Neuronal uptake and neuroprotective effect of curcumin-loaded PLGA nanoparticles on the human SK-N-SH cell line.	Curcumin	46-54	hedgehog acyltransferase	Homo sapiens	94-98
21964250-6	2012	In particular, we tested 17-AAG, ibuprofen, 4-PBA, curcumin, trehalose, congo red and chrysamine G for their ability to i) recover the nuclear localisation of polyAla expanded PHOX2B, ii) rescue of PHOX2B mediated transactivation of the DBH promoter, and iii) clearance of PHOX2B (+13 Ala) aggregates.	Curcumin	51-59	paired like homeobox 2B	Homo sapiens	176-182
21964250-6	2012	In particular, we tested 17-AAG, ibuprofen, 4-PBA, curcumin, trehalose, congo red and chrysamine G for their ability to i) recover the nuclear localisation of polyAla expanded PHOX2B, ii) rescue of PHOX2B mediated transactivation of the DBH promoter, and iii) clearance of PHOX2B (+13 Ala) aggregates.	Curcumin	51-59	paired like homeobox 2B	Homo sapiens	198-204
21964250-6	2012	In particular, we tested 17-AAG, ibuprofen, 4-PBA, curcumin, trehalose, congo red and chrysamine G for their ability to i) recover the nuclear localisation of polyAla expanded PHOX2B, ii) rescue of PHOX2B mediated transactivation of the DBH promoter, and iii) clearance of PHOX2B (+13 Ala) aggregates.	Curcumin	51-59	paired like homeobox 2B	Homo sapiens	198-204
22156608-3	2012	Curcumins restore Abeta phagocytosis by peripheral blood mononuclear cells (PBMCs) from AD patients and Abeta clearance with upregulation of key genes including MGAT3, vitamin D receptor (VDR) and Toll-like receptors (TLRs).	Curcumin	0-9	vitamin D receptor	Homo sapiens	168-186
22156608-3	2012	Curcumins restore Abeta phagocytosis by peripheral blood mononuclear cells (PBMCs) from AD patients and Abeta clearance with upregulation of key genes including MGAT3, vitamin D receptor (VDR) and Toll-like receptors (TLRs).	Curcumin	0-9	vitamin D receptor	Homo sapiens	188-191
22899991-9	2012	In contrast to FLLL32, curcumin and FLLL62 reduced downstream STAT1-mediated gene expression of IRF1 as determined by Real Time PCR.	Curcumin	23-31	signal transducer and activator of transcription 1	Homo sapiens	62-67
22745783-10	2012	Likewise, curcumin prevented the increase of SBP, CRP, TNF alpha, D-dimer and PAI-1.	Curcumin	10-18	C-reactive protein, pentraxin-related	Mus musculus	50-53
22101335-7	2011	Cytochrome c release from mitochondria to the cytosol in curcumin-treated cells was associated with upregulation of proapoptotic proteins such as Bax, Bak, Bid, and Bim.	Curcumin	57-65	BCL2 antagonist/killer 1	Homo sapiens	151-154
21344388-4	2011	As we shown, curcumin inhibited Tat-induced LTR transcativation, while knockdown of histone deacetylase 1 (HDAC1) by siRNA potentiated Tat-induced HIV-1 transcativation.	Curcumin	13-21	Tat	Human immunodeficiency virus 1	32-35
22060292-4	2011	KEY FINDINGS: Curcumin at a concentration of 8 microm was found to suppress the increase in cell size, protein content and enhanced marker gene expression (ANF) caused by noradrenaline.	Curcumin	14-22	natriuretic peptide A	Rattus norvegicus	156-159
21695461-6	2011	The reduced severity of hepatitis in curcumin pretreated mice correlated with decrease in numbers of liver CD4(+) T cells but not CD8(+) T cells by immunohistochemical analysis.	Curcumin	37-45	CD4 antigen	Mus musculus	107-110
35366771-2	2022	Methods- In this research, we developed the amphiphilic Heparin-Poloxamer P403 (HSP) nanogel that can load curcumin (CUR) and Paclitaxel (PTX) through the hydrophobic core of Poloxamer P403.	Curcumin	107-115	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	80-83
35538036-0	2022	Curcumin ameliorates HO-induced injury through SIRT1-PERK-CHOP pathway in pancreatic beta cells.	Curcumin	0-8	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	53-57
35538036-11	2022	Curcumin decreases ROS generation and inhibits protein kinase like ER kinase (PERK)-C/EBP homologous protein (CHOP) signaling axis, one of the critical branches of ER stress pathway.	Curcumin	0-8	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	47-76
35538036-11	2022	Curcumin decreases ROS generation and inhibits protein kinase like ER kinase (PERK)-C/EBP homologous protein (CHOP) signaling axis, one of the critical branches of ER stress pathway.	Curcumin	0-8	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	78-82
35538036-14	2022	In sum, curcumin inhibits the PERK-CHOP pathway of ER stress mediated by SIRT1 and thus ameliorates HO-induced MIN6 cell apoptosis, suggesting that curcumin and SIRT1 may provide a potential therapeutic approach for T1DM.	Curcumin	8-16	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	30-34
35538036-14	2022	In sum, curcumin inhibits the PERK-CHOP pathway of ER stress mediated by SIRT1 and thus ameliorates HO-induced MIN6 cell apoptosis, suggesting that curcumin and SIRT1 may provide a potential therapeutic approach for T1DM.	Curcumin	148-156	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	30-34
35225298-9	2022	Curcumin-treated groups, with and without PZQ, resulted in higher significant Immunoreactivity score (IRS) for Bcl-2-associated X (BAX) and lower Interleukine- 17A (IL-17A), and Human epidermal growth factor (EGF), compared to the control.	Curcumin	0-8	interleukin 17A	Homo sapiens	146-163
35225298-9	2022	Curcumin-treated groups, with and without PZQ, resulted in higher significant Immunoreactivity score (IRS) for Bcl-2-associated X (BAX) and lower Interleukine- 17A (IL-17A), and Human epidermal growth factor (EGF), compared to the control.	Curcumin	0-8	interleukin 17A	Homo sapiens	165-171
35256924-0	2022	Curcumin Inhibits Papillary Thyroid Cancer Cell Proliferation by Regulating lncRNA LINC00691.	Curcumin	0-8	long intergenic non-protein coding RNA 691	Homo sapiens	83-92
35256924-6	2022	Curcumin inhibited LINC00691 expression in B-CPAP cells.	Curcumin	0-8	long intergenic non-protein coding RNA 691	Homo sapiens	19-28
35210750-0	2022	Erratum: Curcumin Protects Against Myocardial Infarction-Induced Cardiac Fibrosis via SIRT1 Activation in vivo and in vitro (Corrigendum).	Curcumin	9-17	sirtuin 1	Homo sapiens	86-91
35120520-11	2022	The docking scores toward proteins 3ODU of CXCR4 and 6K3F of CXCR7 were - 7.71 and - 7.17 for curcumin, - 5.97 and - 6.03 for quercetin, - 5.68 and - 5.49 for trans-resveratrol, and - 4.88 and - 4.70 for (1 s,4 s)-eucalyptol respectively indicating that all compounds, except quercetin, have more interactions with CXCR4 than with CXCR7.	Curcumin	94-102	C-X-C motif chemokine receptor 4	Homo sapiens	315-320
35120520-11	2022	The docking scores toward proteins 3ODU of CXCR4 and 6K3F of CXCR7 were - 7.71 and - 7.17 for curcumin, - 5.97 and - 6.03 for quercetin, - 5.68 and - 5.49 for trans-resveratrol, and - 4.88 and - 4.70 for (1 s,4 s)-eucalyptol respectively indicating that all compounds, except quercetin, have more interactions with CXCR4 than with CXCR7.	Curcumin	94-102	atypical chemokine receptor 3	Homo sapiens	331-336
35120520-16	2022	CONCLUSIONS: Curcumin showed the top binding interaction against active sites of CXCR4 and CXCR7 receptors, with the best safety profile, followed by quercetin, resveratrol, and eucalyptol.	Curcumin	13-21	C-X-C motif chemokine receptor 4	Homo sapiens	81-86
35120520-16	2022	CONCLUSIONS: Curcumin showed the top binding interaction against active sites of CXCR4 and CXCR7 receptors, with the best safety profile, followed by quercetin, resveratrol, and eucalyptol.	Curcumin	13-21	atypical chemokine receptor 3	Homo sapiens	91-96
35066694-9	2022	Further study proved that Curcumin treatment resulted in inhibition of SQLE, a key enzyme of cholesterol biosynthesis, to increase sensitivity to Ara-C.	Curcumin	26-34	squalene epoxidase	Mus musculus	71-75
34980778-9	2022	Mechanistically, curcumin + HH suppressed protein expression of stromal cell-derived factor-1 (SDF-1), CXC chemokine receptor 4 (CXCR4), p-Akt, and c-fos while enhancing protein expression of nerve growth factor (NGF) in the dorsal root ganglia (DRG) of model rats.	Curcumin	17-25	C-X-C motif chemokine receptor 4	Rattus norvegicus	103-127
34980778-9	2022	Mechanistically, curcumin + HH suppressed protein expression of stromal cell-derived factor-1 (SDF-1), CXC chemokine receptor 4 (CXCR4), p-Akt, and c-fos while enhancing protein expression of nerve growth factor (NGF) in the dorsal root ganglia (DRG) of model rats.	Curcumin	17-25	C-X-C motif chemokine receptor 4	Rattus norvegicus	129-134
34980778-9	2022	Mechanistically, curcumin + HH suppressed protein expression of stromal cell-derived factor-1 (SDF-1), CXC chemokine receptor 4 (CXCR4), p-Akt, and c-fos while enhancing protein expression of nerve growth factor (NGF) in the dorsal root ganglia (DRG) of model rats.	Curcumin	17-25	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	148-153
34980778-11	2022	Coadministration of curcumin and HH alleviates incision + formaldehyde-induced pain in rats, possibly by suppressing the SDF-1/CXCR4 pathway and the production of proinflammatory mediators.	Curcumin	20-28	C-X-C motif chemokine receptor 4	Rattus norvegicus	127-132
35549587-0	2022	Curcumin alleviated lipopolysaccharide-evoked H9c2 cells damage via suppression of intercellular adhesion molecule 1/CD40/NF-kappaB signaling.	Curcumin	0-8	intercellular adhesion molecule 1	Rattus norvegicus	83-116
35549587-9	2022	ICAM1 and CD40, which highly expressed in myocarditis patients, were identified as targets of curcumin and negatively regulated by curcumin.	Curcumin	94-102	intercellular adhesion molecule 1	Homo sapiens	0-5
35549587-9	2022	ICAM1 and CD40, which highly expressed in myocarditis patients, were identified as targets of curcumin and negatively regulated by curcumin.	Curcumin	131-139	intercellular adhesion molecule 1	Homo sapiens	0-5
35549587-10	2022	Inhibition of ICAM1 or CD40 strengthened the protective effect of curcumin on LPS-evoked H9c2 cells damage, accompanied by increased cell viability and decreased cell apoptosis and inflammation.	Curcumin	66-74	intercellular adhesion molecule 1	Rattus norvegicus	14-19
35549587-12	2022	CONCLUSIONS: Curcumin mitigated LPS-evoked H9c2 cells damage by suppression of ICAM1/CD40/NF-kappaB, providing a potential molecular mechanism for the clinical application of curcumin.	Curcumin	13-21	intercellular adhesion molecule 1	Rattus norvegicus	79-84
35549587-12	2022	CONCLUSIONS: Curcumin mitigated LPS-evoked H9c2 cells damage by suppression of ICAM1/CD40/NF-kappaB, providing a potential molecular mechanism for the clinical application of curcumin.	Curcumin	175-183	intercellular adhesion molecule 1	Rattus norvegicus	79-84
35012734-0	2022	Expression of Concern "Curcumin inhibits proliferation and soluble collagen synthesis of NIH/3T3 cell line by modulation of miR-29a and via ERK1/2 and beta-catenin pathways" (Mol.	Curcumin	23-31	catenin (cadherin associated protein), beta 1	Mus musculus	151-163
21787756-5	2011	The aim of this study is to investigate the potential of curcumin (CUR), a dietary compound that we have reported to be able to prevent the development of prostate cancer in TRAMP mice, as a DNA hypomethylation agent.	Curcumin	57-65	translocating chain-associating membrane protein 1	Mus musculus	174-179
22045655-11	2011	CONCLUSION: Curcumin exerts its anti-cancer property by targeting PDE1 that inhibits melanoma cell proliferation via UHRF1, DNMT1, cyclin A, p21 and p27 regulations.	Curcumin	12-20	cyclin-dependent kinase inhibitor 1B	Mus musculus	149-152
21627988-9	2011	The treatment of curcumin, the anticancer drug along with HABP1, inhibited the migration, expression of MT1-MMP and activation of MMP-2 and finally tumor growth supports the involvement of HABP1 in tumor formation.	Curcumin	17-25	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	104-111
21627988-9	2011	The treatment of curcumin, the anticancer drug along with HABP1, inhibited the migration, expression of MT1-MMP and activation of MMP-2 and finally tumor growth supports the involvement of HABP1 in tumor formation.	Curcumin	17-25	matrix metallopeptidase 2	Mus musculus	130-135
21810436-4	2011	Therefore, in the current study, we will examine whether curcumin could enhance the effects of mitomycin C (MMC), a DNA interstrand cross-linking agent, to induce cytotoxicity by decreasing Rad51 expression.	Curcumin	57-65	RAD51 recombinase	Homo sapiens	190-195
21810436-5	2011	Exposure of two human non-small lung cancer (NSCLC) cell lines (A549 and H1975) to curcumin could suppress MMC-induced MKK1/2-ERK1/2 signal activation and Rad51 protein expression.	Curcumin	83-91	RAD51 recombinase	Homo sapiens	155-160
21810436-6	2011	Enhancement of ERK1/2 activation by constitutively active MKK1/2 (MKK1/2-CA) increased Rad51 protein levels in curcumin and MMC co-treated human lung cells.	Curcumin	111-119	RAD51 recombinase	Homo sapiens	87-92
22973975-7	2012	Preincubation of Detroit cells with 200 muM curcumin for 5 to 60 min resulted in complete suppression of the release of tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, monocyte chemoattractant protein 1, granulocyte macrophage-colony stimulating factor, and vascular endothelial growth factor.	Curcumin	44-52	C-C motif chemokine ligand 2	Homo sapiens	175-209
22973975-7	2012	Preincubation of Detroit cells with 200 muM curcumin for 5 to 60 min resulted in complete suppression of the release of tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, monocyte chemoattractant protein 1, granulocyte macrophage-colony stimulating factor, and vascular endothelial growth factor.	Curcumin	44-52	colony stimulating factor 2	Homo sapiens	211-259
22403681-0	2012	Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer"s disease.	Curcumin	0-8	tet methylcytosine dioxygenase 1	Homo sapiens	51-56
21810436-8	2011	In contrast, MKK1/2 inhibitor, U0126 was shown to augment the cytotoxicity of curcumin and MMC through downregulation of ERK1/2 activation and Rad51 expression.	Curcumin	78-86	RAD51 recombinase	Homo sapiens	143-148
21810436-9	2011	Depletion of endogenous Rad51 expression by siRad51 RNA transfection significantly enhanced MMC and/or curcumin induced cell death and cell growth inhibition.	Curcumin	103-111	RAD51 recombinase	Homo sapiens	24-29
21810436-10	2011	In contrast, an overexpression of Rad51 protected lung cancer cells from synergistic cytotoxic effects induced by curcumin and MMC.	Curcumin	114-122	RAD51 recombinase	Homo sapiens	34-39
21810436-11	2011	We concluded that Rad51 inhibition may be an additional action mechanism for enhancing the chemosensitization of MMC by curcumin in NSCLC.	Curcumin	120-128	RAD51 recombinase	Homo sapiens	18-23
21633290-0	2011	Curcumin and resveratrol synergistically stimulate p21 and regulate cox-2 by maintaining adequate zinc levels during lung carcinogenesis.	Curcumin	0-8	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	51-54
21633290-1	2011	This study explored the efficacy of curcumin and resveratrol in maintaining adequate zinc levels to regulate p21 and cyclooxygenase-2 (cox-2) during benzo[a]pyrene (BP)-induced lung carcinogenesis.	Curcumin	36-44	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	109-112
21442673-0	2011	Curcumin and a Morus alba extract reduce pro-inflammatory effects of resistin in human endothelial cells.	Curcumin	0-8	resistin	Homo sapiens	69-77
21633290-5	2011	Interestingly, combined supplementation of curcumin and resveratrol to BP-treated mice resulted in an appreciable improvement in the zinc levels and protein expression of p21.	Curcumin	43-51	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	171-174
21633290-7	2011	This study, therefore, concludes that combined treatment with curcumin and resveratrol maintains adequate zinc levels and regulates inflammation by cox-2 and cell cycle arrest by p21 during lung carcinogenesis in mice.	Curcumin	62-70	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	179-182
21689105-7	2011	Curcumin was also found to regulate corticosterone-induced morphological changes such as increases in soma size, dendritic branching and dendritic spine density, as well as elevate synaptophysin expression in cortical neurons.	Curcumin	0-8	synaptophysin	Homo sapiens	181-194
21689105-8	2011	p-MPPI and RS 39604 reversed the effect of curcumin-induced change in neuronal morphology and synaptophysin expression of corticosterone-treated neurons.	Curcumin	43-51	synaptophysin	Homo sapiens	94-107
21689105-11	2011	These findings suggest that the neuroprotection and modulation of neuroplasticity exhibited by curcumin might be mediated, at least in part, via the 5-HT receptor-cAMP-PKA-CREB signal pathway.	Curcumin	95-103	cAMP responsive element binding protein 1	Homo sapiens	172-176
21442673-8	2011	The results indicate that MA and curcumin target resistin-induced human endothelial activation partly via antioxidant mechanisms and suggest that they may represent therapeutic agents in vascular disease mediated by resistin.	Curcumin	33-41	resistin	Homo sapiens	49-57
21906467-0	2011	[Effect of curcumin on IL-17-induced nitric oxide production and expression of iNOS in human keratinocytes].	Curcumin	11-19	interleukin 17A	Homo sapiens	23-28
21442673-8	2011	The results indicate that MA and curcumin target resistin-induced human endothelial activation partly via antioxidant mechanisms and suggest that they may represent therapeutic agents in vascular disease mediated by resistin.	Curcumin	33-41	resistin	Homo sapiens	216-224
21906467-1	2011	AIM: To investigate the effect of curcumin on IL-17-induced NO production, mRNA and protein expression of iNOS in human keratinocyte cell lines(HaCaT cells).	Curcumin	34-42	interleukin 17A	Homo sapiens	46-51
21906467-5	2011	Curcumin decreased IL-17 induced NO production and the iNOS expression at mRNA (P&lt;0.01) and protein (P&lt;0.01) levels significantly.	Curcumin	0-8	interleukin 17A	Homo sapiens	19-24
21827816-1	2011	The present study was planned to investigate the antigenotoxic effects of curcumin and piperine separately and in combination against benzo(a)pyrene (BaP) induced DNA damage in lungs and livers of mice.	Curcumin	74-82	prohibitin 2	Mus musculus	150-153
21906467-6	2011	CONCLUSION: Curcumin down-regulates IL-17-induced NO secretions and iNOS expression in HaCaT cells, thus provides a theoretical basis for the treatment of inflammatory diseases of skin related to keratinocytes.	Curcumin	12-20	interleukin 17A	Homo sapiens	36-41
21593220-0	2011	Rescue of ATP7B function in hepatocyte-like cells from Wilson"s disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin.	Curcumin	144-152	ATPase copper transporting beta	Homo sapiens	10-15
21827816-4	2011	Pretreatments of curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of 8-oxo-dG content and % DNA in the comet tail in both the tissues.	Curcumin	17-25	prohibitin 2	Mus musculus	93-96
21827816-4	2011	Pretreatments of curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of 8-oxo-dG content and % DNA in the comet tail in both the tissues.	Curcumin	30-38	prohibitin 2	Mus musculus	93-96
21827816-5	2011	Moreover, the genoprotective potential of curcumin plus piperine was significantly higher as compared to curcumin alone against BaP induced DNA damage.	Curcumin	42-50	prohibitin 2	Mus musculus	128-131
21741425-7	2011	Furthermore, the inhibitory effect of curcumin on evoked glutamate release was prevented by blocking the Ca(v)2.2 (N-type) and Ca(v)2.1 (P/Q-type) channels, but not by blocking intracellular Ca(2+) release or Na(+)/Ca(2+) exchange.	Curcumin	38-46	calcium voltage-gated channel subunit alpha1 A	Rattus norvegicus	127-135
21741425-8	2011	These results suggest that curcumin inhibits evoked glutamate release from rat prefrontocortical synaptosomes by the suppression of presynaptic Ca(v)2.2 and Ca(v)2.1 channels.	Curcumin	27-35	calcium voltage-gated channel subunit alpha1 A	Rattus norvegicus	157-165
21669872-11	2011	Curcumin suppressed IL-1beta-induced PI-3K p85/Akt activation and its association with IKK.	Curcumin	0-8	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	43-46
21827816-5	2011	Moreover, the genoprotective potential of curcumin plus piperine was significantly higher as compared to curcumin alone against BaP induced DNA damage.	Curcumin	105-113	prohibitin 2	Mus musculus	128-131
21732406-6	2011	Curcumin generated an aberrant RANKL signal characterized by reduced expression of nuclear factor of activated T cells 2 (NFAT2) and attenuated activation of mitogen-activated protein kinases (ERK, JNK, and p38).	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	31-36
21732406-7	2011	Curcumin thus inhibited OVX-induced bone loss, at least in part by reducing osteoclastogenesis as a result of increased antioxidant activity and impaired RANKL signaling.	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	154-159
21936051-0	2011	Curcumin provides potential protection against the activation of hypoxia and prolyl 4-hydroxylase inhibitors on prostate-specific antigen expression in human prostate carcinoma cells.	Curcumin	0-8	kallikrein related peptidase 3	Homo sapiens	112-137
21936051-3	2011	We examined the effects of curcumin on increasing PSA expression by hypoxia and prolyl hydroxylase inhibitors, L-mimosine and dimethyloxalylglycine (DMOG), in human prostate carcinoma LNCaP cells.	Curcumin	27-35	kallikrein related peptidase 3	Homo sapiens	50-53
21380847-6	2011	Furthermore, our results show that the hormetic effects of low levels of curcumin are achieved by virtue of it being a hormetin in terms of the induction of stress response pathways, including Nrf2 and HO-1 in human cells.	Curcumin	73-81	heme oxygenase 1	Homo sapiens	202-206
21641422-0	2011	Curcumin induced nanoscale CD44 molecular redistribution and antigen-antibody interaction on HepG2 cell surface.	Curcumin	0-8	CD44 molecule (Indian blood group)	Homo sapiens	27-31
21314641-7	2011	Moreover, pretreatment of cells with curcumin, an activation of AP-1 (activator protein-1) inhibitor, inhibited silica-induced cell cycle alteration, the decreased expression of E2F-4 and overexpression of cyclin D1 and CDK4.	Curcumin	37-45	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	64-68
21314641-7	2011	Moreover, pretreatment of cells with curcumin, an activation of AP-1 (activator protein-1) inhibitor, inhibited silica-induced cell cycle alteration, the decreased expression of E2F-4 and overexpression of cyclin D1 and CDK4.	Curcumin	37-45	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	70-89
21570847-2	2011	A tartarate-resistant acid phosphatase (TRAP) activity assay was carried out with RANKL-induced osteoclastogenesis of mouse monocyte/macrophage RAW264.7 cells; the results indicated that the curcumin mimics derived from intermediate 10 exhibited stronger inhibitory activity than 9.	Curcumin	191-199	acid phosphatase 5, tartrate resistant	Mus musculus	2-38
21958395-9	2011	Curcumin effectively triggered anti-inflammatory signals as shown by induced expression of Interleukin 4 and Peroxisome proliferator activated receptor alpha.	Curcumin	0-8	interleukin 4	Mus musculus	91-157
21570847-2	2011	A tartarate-resistant acid phosphatase (TRAP) activity assay was carried out with RANKL-induced osteoclastogenesis of mouse monocyte/macrophage RAW264.7 cells; the results indicated that the curcumin mimics derived from intermediate 10 exhibited stronger inhibitory activity than 9.	Curcumin	191-199	acid phosphatase 5, tartrate resistant	Mus musculus	40-44
21958395-10	2011	Several novel curcumin-induced genes including Netrin G1, Delta-like 1, Platelet endothelial cell adhesion molecule 1, and Plasma cell endoplasmic reticulum protein 1, have been previously associated with adhesion and cell migration.	Curcumin	14-22	netrin G1	Mus musculus	47-70
21419841-6	2011	Curcumin at 5-10 muM increased the populations of shrunken cells and the cells positive to annexin V, phenomena for early stage of apoptosis.	Curcumin	0-8	annexin A5	Rattus norvegicus	91-100
21810436-0	2011	Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells.	Curcumin	0-8	mitogen-activated protein kinase kinase 1	Homo sapiens	77-81
21506134-0	2011	Effects of oral curcumin on the pharmacokinetics of intravenous and oral etoposide in rats: possible role of intestinal CYP3A and P-gp inhibition by curcumin.	Curcumin	149-157	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	130-134
21325634-9	2011	Fourth, curcumin upregulated death receptors, DR4 and DR5.	Curcumin	8-16	TNF receptor superfamily member 10b	Homo sapiens	54-57
21506134-9	2011	Therefore, the enhanced oral bioavailability of etoposide in the presence of curcumin might be due mainly to inhibition of the P-gp efflux pump in the small intestine and possibly by reduced first-pass metabolism of etoposide in the small intestine by inhibition of CYP3A activity in rats.	Curcumin	77-85	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	127-131
21325634-11	2011	Sixth, curcumin inhibited expression of cell survival proteins such as B-cell lymphoma-2, B-cell leukemia protein xL, X-linked inhibitor of apoptosis protein, c-FLIP, cellular inhibitor of apoptosis protein (cIAP)-1, cIAP-2 and survivin and proteins linked to cell proliferation, such as cyclin D1 and c-Myc.	Curcumin	7-15	baculoviral IAP repeat containing 3	Homo sapiens	217-223
21295102-7	2011	Pretreatment with curcumin significantly increased DOX-induced apoptosis of cardiac muscle cells through down regulation of Bcl-2, up-regulation of caspase-8 and caspase-9.	Curcumin	18-26	caspase 8	Rattus norvegicus	148-157
21325634-11	2011	Sixth, curcumin inhibited expression of cell survival proteins such as B-cell lymphoma-2, B-cell leukemia protein xL, X-linked inhibitor of apoptosis protein, c-FLIP, cellular inhibitor of apoptosis protein (cIAP)-1, cIAP-2 and survivin and proteins linked to cell proliferation, such as cyclin D1 and c-Myc.	Curcumin	7-15	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	302-307
21237271-9	2011	This study demonstrate that curcumin protected against A53T mutant alpha-synuclein-induced cell death via inhibition of oxidative stress and the mitochondrial cell death pathway, suggesting that curcumin may be a candidate neuroprotective agent for A53T alpha-synuclein-linked Parkinsonism, and possibly for other genetic or sporadic forms of PD.	Curcumin	195-203	synuclein alpha	Rattus norvegicus	254-269
21859497-4	2011	The oncogenic pathways inhibited by curcumin encompass the members of epidermal growth factor receptors (EGFR and erbB2), sonic hedgehog (SHH)/GLIs and Wnt/beta-catenin and downstream signaling elements such as Akt, nuclear factor-kappa B (NF-kappaB) and signal transducers and activators of transcription (STATs).	Curcumin	36-44	sonic hedgehog signaling molecule	Homo sapiens	122-136
21842651-6	2011	RESULT: The expression of ATP synthesis H+ transporting, MHC class II, non-muscle myosin alkali light chain and cytochrome b5 increased in the RAW264.7 cell treated with 25 micromol x L(-1) curcumin, while the expression of phosphodiesterase 4D, elF-3, Hnrpf protein, vimentin, nucleophosminl and Ranbp 1 decreased.	Curcumin	190-198	E74-like factor 3	Mus musculus	246-251
21842651-6	2011	RESULT: The expression of ATP synthesis H+ transporting, MHC class II, non-muscle myosin alkali light chain and cytochrome b5 increased in the RAW264.7 cell treated with 25 micromol x L(-1) curcumin, while the expression of phosphodiesterase 4D, elF-3, Hnrpf protein, vimentin, nucleophosminl and Ranbp 1 decreased.	Curcumin	190-198	heterogeneous nuclear ribonucleoprotein F	Mus musculus	253-258
21842651-6	2011	RESULT: The expression of ATP synthesis H+ transporting, MHC class II, non-muscle myosin alkali light chain and cytochrome b5 increased in the RAW264.7 cell treated with 25 micromol x L(-1) curcumin, while the expression of phosphodiesterase 4D, elF-3, Hnrpf protein, vimentin, nucleophosminl and Ranbp 1 decreased.	Curcumin	190-198	vimentin	Mus musculus	268-276
21859497-4	2011	The oncogenic pathways inhibited by curcumin encompass the members of epidermal growth factor receptors (EGFR and erbB2), sonic hedgehog (SHH)/GLIs and Wnt/beta-catenin and downstream signaling elements such as Akt, nuclear factor-kappa B (NF-kappaB) and signal transducers and activators of transcription (STATs).	Curcumin	36-44	sonic hedgehog signaling molecule	Homo sapiens	138-141
21859497-4	2011	The oncogenic pathways inhibited by curcumin encompass the members of epidermal growth factor receptors (EGFR and erbB2), sonic hedgehog (SHH)/GLIs and Wnt/beta-catenin and downstream signaling elements such as Akt, nuclear factor-kappa B (NF-kappaB) and signal transducers and activators of transcription (STATs).	Curcumin	36-44	catenin beta 1	Homo sapiens	156-168
21354353-7	2011	Treatment with curcumin also resulted in significant reduction in serum and tissue level of TNF-alpha, IL-1beta, IL-12, IL-18 and INF-gamma that were increased by renal I/R injury (p&lt;0.05).	Curcumin	15-23	interleukin 12B	Rattus norvegicus	113-118
21443863-0	2011	Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling.	Curcumin	0-8	interleukin 2 receptor, alpha chain	Mus musculus	92-96
21354353-7	2011	Treatment with curcumin also resulted in significant reduction in serum and tissue level of TNF-alpha, IL-1beta, IL-12, IL-18 and INF-gamma that were increased by renal I/R injury (p&lt;0.05).	Curcumin	15-23	interleukin 18	Rattus norvegicus	120-125
21443863-0	2011	Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling.	Curcumin	0-8	interleukin 2 receptor, alpha chain	Mus musculus	113-126
21443863-2	2011	Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4(+) T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 (alpha chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28.	Curcumin	47-55	CD4 antigen	Mus musculus	89-92
21538854-4	2011	In addition, we demonstrated a relationship between curcumin treatment and the expression of VEGF, EGFR, ERK2, and Cyclin A at the transcriptional and translational levels.	Curcumin	52-60	epidermal growth factor receptor	Mus musculus	99-103
21443863-2	2011	Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4(+) T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 (alpha chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28.	Curcumin	47-55	interleukin 2 receptor, alpha chain	Mus musculus	147-151
21443863-2	2011	Here we show that micromolar concentrations of curcumin inhibited DNA synthesis by mouse CD4(+) T-lymphocytes, as well as interleukin-2 (IL-2) and CD25 (alpha chain of the high affinity IL-2 receptor) expression in response to antibody-mediated cross-linking of CD3 and CD28.	Curcumin	47-55	interleukin 2 receptor, alpha chain	Mus musculus	186-199
21443863-4	2011	In addition, IL-2-dependent DNA synthesis by mouse CTLL-2 cells, but not constitutive CD25 expression, was impaired in the presence of curcumin, which demonstrated an inhibitory effect on IL-2 receptor (IL-2R) signaling.	Curcumin	135-143	interleukin 2 receptor, alpha chain	Mus musculus	188-201
20227862-9	2011	The effects of curcumin on these enzymes except for GS were suppressed by AMPK inhibitor, Compound C. LKB1, an upstream kinase of AMPK, was activated by curcumin and inhibited by radicicol, an LKB1 destabilizer.	Curcumin	15-23	serine/threonine kinase 11	Rattus norvegicus	102-106
21443863-4	2011	In addition, IL-2-dependent DNA synthesis by mouse CTLL-2 cells, but not constitutive CD25 expression, was impaired in the presence of curcumin, which demonstrated an inhibitory effect on IL-2 receptor (IL-2R) signaling.	Curcumin	135-143	interleukin 2 receptor, alpha chain	Mus musculus	203-208
21443863-5	2011	IL-2-induced phosphorylation of STAT5A and JAK3, but not JAK1, was diminished in the presence of curcumin, indicating inhibition of critical proximal events in IL-2R signaling.	Curcumin	97-105	interleukin 2 receptor, alpha chain	Mus musculus	160-165
20227862-9	2011	The effects of curcumin on these enzymes except for GS were suppressed by AMPK inhibitor, Compound C. LKB1, an upstream kinase of AMPK, was activated by curcumin and inhibited by radicicol, an LKB1 destabilizer.	Curcumin	15-23	serine/threonine kinase 11	Rattus norvegicus	193-197
21443863-6	2011	In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4(+)CD25(+) regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression.	Curcumin	38-46	interleukin 2 receptor, alpha chain	Mus musculus	50-55
21443863-6	2011	In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4(+)CD25(+) regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression.	Curcumin	38-46	CD4 antigen	Mus musculus	83-86
20227862-9	2011	The effects of curcumin on these enzymes except for GS were suppressed by AMPK inhibitor, Compound C. LKB1, an upstream kinase of AMPK, was activated by curcumin and inhibited by radicicol, an LKB1 destabilizer.	Curcumin	153-161	serine/threonine kinase 11	Rattus norvegicus	102-106
21443863-6	2011	In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4(+)CD25(+) regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression.	Curcumin	38-46	interleukin 2 receptor, alpha chain	Mus musculus	89-93
21443863-6	2011	In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4(+)CD25(+) regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression.	Curcumin	121-129	interleukin 2 receptor, alpha chain	Mus musculus	50-55
20227862-9	2011	The effects of curcumin on these enzymes except for GS were suppressed by AMPK inhibitor, Compound C. LKB1, an upstream kinase of AMPK, was activated by curcumin and inhibited by radicicol, an LKB1 destabilizer.	Curcumin	153-161	serine/threonine kinase 11	Rattus norvegicus	193-197
21443863-6	2011	In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4(+)CD25(+) regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression.	Curcumin	121-129	CD4 antigen	Mus musculus	83-86
21443863-6	2011	In line with the inhibitory action of curcumin on IL-2R signaling, pretreatment of CD4(+)CD25(+) regulatory T-cells with curcumin downregulated suppressor function, as well as forkhead box p3 (Foxp3) expression.	Curcumin	121-129	interleukin 2 receptor, alpha chain	Mus musculus	89-93
20227862-10	2011	CONCLUSION: Curcumin improves muscular insulin resistance by increasing oxidation of fatty acid and glucose, which is, at least in part, mediated through LKB1-AMPK pathway.	Curcumin	12-20	serine/threonine kinase 11	Rattus norvegicus	154-158
21443863-7	2011	We conclude that curcumin inhibits IL-2 signaling by reducing available IL-2 and high affinity IL-2R, as well as interfering with IL-2R signaling.	Curcumin	17-25	interleukin 2 receptor, alpha chain	Mus musculus	95-100
21443863-7	2011	We conclude that curcumin inhibits IL-2 signaling by reducing available IL-2 and high affinity IL-2R, as well as interfering with IL-2R signaling.	Curcumin	17-25	interleukin 2 receptor, alpha chain	Mus musculus	130-135
21811692-11	2011	Curcumin also attenuated DNA binding activity of p50 and p65 subunits and suppressed STAT1 phosphorylation.	Curcumin	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	57-60
21631512-4	2011	Curcumin, helenalin, and cinnamaldehyde with alpha, beta-unsaturated carbonyl groups, or sulforaphane with an isothiocyanate group, inhibit TLR4 activation by interfering with cysteine residue-mediated receptor dimerization, while resveratrol, with no unsaturated carbonyl group, did not.	Curcumin	0-8	toll like receptor 4	Homo sapiens	140-144
29147235-0	2011	Curcumin Induces Apoptosis in EJ Bladder Cancer Cells via Modulating C-Myc and PI3K/Akt Signaling Pathway.	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	69-74
21236354-3	2011	Furthermore, exposure of cells to 10-50 muM curcumin for 24h induced HSP30 and HSP70 accumulation.	Curcumin	44-52	heat shock protein 30E L homeolog	Xenopus laevis	69-74
21236354-5	2011	Additionally, elevation of the incubation temperature from 22 to 30  C greatly enhanced the curcumin-induced accumulation of HSP30 and HSP70.	Curcumin	92-100	heat shock protein 30E L homeolog	Xenopus laevis	125-130
21236354-6	2011	Immunocytochemical analysis revealed that curcumin-induced HSP30 was detectable primarily in the cytoplasm in a punctate pattern with minimal detrimental effects on the actin cytoskeleton.	Curcumin	42-50	heat shock protein 30E L homeolog	Xenopus laevis	59-64
29147235-6	2011	Immunoblot showed that curcumin increased expression levels of c-myc and inhibited the activation of PI3K/Akt pathway in a time-dependent manner in EJ cells.	Curcumin	23-31	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	63-68
29147235-8	2011	Conclusions: These findings establish a mechanistic linkup or interaction between c-myc, Bax, Bad, Bcl-2, caspase cascades, PI3K/Akt pathway and curcumin- induced apoptosis of EJ cells, suggesting that c-myc and PI3K/Akt signaling pathway play important roles in curcumin-induced apoptosis of EJ bladder cancer cells.	Curcumin	145-153	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	82-87
29147235-8	2011	Conclusions: These findings establish a mechanistic linkup or interaction between c-myc, Bax, Bad, Bcl-2, caspase cascades, PI3K/Akt pathway and curcumin- induced apoptosis of EJ cells, suggesting that c-myc and PI3K/Akt signaling pathway play important roles in curcumin-induced apoptosis of EJ bladder cancer cells.	Curcumin	145-153	caspase 9	Homo sapiens	106-113
21070853-5	2011	The expression of ApoE and ABCA1 induced by synthetic or natural LXR ligands [TO901317, GW3965, and 22-(R)-hydroxycholesterol (22-(R)-HC), respectively] was attenuated by inhibitors of c-Jun N-terminal kinase (JNK) (curcumin and SP600125) and phosphoinositide 3-kinase (PI3K) (LY294002).	Curcumin	216-224	ATP binding cassette subfamily A member 1	Homo sapiens	27-32
29147235-8	2011	Conclusions: These findings establish a mechanistic linkup or interaction between c-myc, Bax, Bad, Bcl-2, caspase cascades, PI3K/Akt pathway and curcumin- induced apoptosis of EJ cells, suggesting that c-myc and PI3K/Akt signaling pathway play important roles in curcumin-induced apoptosis of EJ bladder cancer cells.	Curcumin	145-153	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	202-207
21272158-0	2011	Curcumin analog GO-Y030 is a novel inhibitor of IKKbeta that suppresses NF-kappaB signaling and induces apoptosis.	Curcumin	0-8	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	48-55
21114990-8	2011	Plasma levels of VEGF were significantly reduced in groups treated with resveratrol or curcumin and their combination with carboplatin on day 7 post-inoculation.	Curcumin	87-95	vascular endothelial growth factor A	Mus musculus	17-21
21084858-8	2011	In conclusion, curcumin has the ability to inhibit the growth of engrafted melanoma VM channels through the regulation of vasculogenic factors that could be related to the down-regulation of the EphA2/PI3K/MMPs signaling pathway.	Curcumin	15-23	matrix metallopeptidase 2	Mus musculus	206-210
21352912-10	2011	Curcumin could activate the Wnt/beta-catenin signaling pathway through inhibiting the expression of GSK-3beta and inducing the expression of beta-catenin and CyclinD1, which will provide a new theory for treatment of neurodegenerative diseases by Curcumin.	Curcumin	247-255	catenin beta 1	Homo sapiens	141-166
21415532-10	2011	The results demonstrated that curcumin could inhibit LPS-induced renal MCP-1 mRNA expression.	Curcumin	30-38	chemokine (C-C motif) ligand 2	Mus musculus	71-76
21415532-11	2011	Curcumin also significantly inhibited the expression of MCP-1 and IL-2 mRNA in HK-2 cells, and partially inhibited the secretion of MCP-1 and IL-8.	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	56-61
21415532-11	2011	Curcumin also significantly inhibited the expression of MCP-1 and IL-2 mRNA in HK-2 cells, and partially inhibited the secretion of MCP-1 and IL-8.	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	132-137
21415532-13	2011	The present study demonstrated that curcumin has a protective effect on LPS-induced experimental renal inflammation, and this effect might be attributed to its inhibitory effects on MCP-1 mRNA expression and DNA-binding activity of NF-kappaB.	Curcumin	36-44	chemokine (C-C motif) ligand 2	Mus musculus	182-187
21393628-9	2011	By contrast, the pan-JAK inhibitor curcumin inhibited the activity of this reporter following treatment with either IL-2 or IL-3.	Curcumin	35-43	interleukin 2	Mus musculus	116-120
22179005-0	2011	Curcumin blocks Kv11.1 (erg) potassium current and slows proliferation in the infant acute monocytic leukemia cell line THP-1.	Curcumin	0-8	potassium voltage-gated channel modifier subfamily V member 2	Homo sapiens	16-22
22179005-5	2011	In addition, curcumin, a natural polyphenol derived from the plant Curcuma longa, effectively blocked Kv11.1 activity and also inhibited the proliferation of these cells.	Curcumin	13-21	potassium voltage-gated channel modifier subfamily V member 2	Homo sapiens	102-108
22179005-8	2011	We propose that the inhibition of Kv11.1 activity by curcumin may lead to interference with leukemic cell physiology and consequently the suppression of survival and proliferation of AML cells.	Curcumin	53-61	potassium voltage-gated channel modifier subfamily V member 2	Homo sapiens	34-40
21809590-0	2011	[Effect of curcumin on expression of Abeta42 and Abeta-degrading enzyme NEP in APPswe/PS1dE9 double transgenic mice].	Curcumin	11-19	tensin 2	Mus musculus	72-75
21343666-5	2011	Consistently, dose-dependent inhibition of I(CRAC) by curcumin was confirmed in Jurkat-T (IC(50), 5.9 microM) and the HEK293 cells overexpressing Orai1 and STIM1 (IC(50), 0.6 microM).	Curcumin	54-62	ORAI calcium release-activated calcium modulator 1	Homo sapiens	146-151
21858220-5	2011	In addition, the anti-tumor activity of gefitinib was potentiated via curcumin through blocking EGFR activation and inducing apoptosis in gefitinib-resistant NSCLC cell lines; also the combined treatment with curcumin and gefitinib exhibited significant inhibition in the CL1-5, A549 and H1975 xenografts tumor growth in SCID mice through reducing EGFR, c-MET, cyclin D1 expression, and inducing apoptosis activation through caspases-8, 9 and PARP.	Curcumin	70-78	cyclin D1	Mus musculus	361-370
21858220-5	2011	In addition, the anti-tumor activity of gefitinib was potentiated via curcumin through blocking EGFR activation and inducing apoptosis in gefitinib-resistant NSCLC cell lines; also the combined treatment with curcumin and gefitinib exhibited significant inhibition in the CL1-5, A549 and H1975 xenografts tumor growth in SCID mice through reducing EGFR, c-MET, cyclin D1 expression, and inducing apoptosis activation through caspases-8, 9 and PARP.	Curcumin	70-78	poly (ADP-ribose) polymerase family, member 1	Mus musculus	443-447
21138870-7	2010	Real-time RT-PCR revealed that curcumin downregulated transcription of the STAT3 target genes c-Myc, MMP-9, Snail, and Twist, and of the proliferation marker Ki67.	Curcumin	31-39	snail family zinc finger 1	Mus musculus	108-113
19730790-7	2010	Gelatin zymography and Western blotting showed that reduced cell invasion with curcumin and PKF118-310 treatment correlated with the activity and protein level of matrix metalloproteinase-9 under conditions of intrinsic or extrinsic Wnt/beta-catenin activation.	Curcumin	79-87	matrix metallopeptidase 9	Homo sapiens	163-189
21809590-1	2011	OBJECTIVE: To observe the effect of curcumin on the expression of Abeta42 and its degrading enzyme NEP in APP/PS1 double transgenic mice.	Curcumin	36-44	tensin 2	Mus musculus	99-102
21809590-1	2011	OBJECTIVE: To observe the effect of curcumin on the expression of Abeta42 and its degrading enzyme NEP in APP/PS1 double transgenic mice.	Curcumin	36-44	presenilin 1	Mus musculus	110-113
21809590-6	2011	CONCLUSION: Curcumin can improve learning and memory ability of APP/PS1 double transgenic mice through increasing the expression of Abeta-degrading enzyme NEP and decreasing the expression of Abeta42.	Curcumin	12-20	presenilin 1	Mus musculus	68-71
21809590-6	2011	CONCLUSION: Curcumin can improve learning and memory ability of APP/PS1 double transgenic mice through increasing the expression of Abeta-degrading enzyme NEP and decreasing the expression of Abeta42.	Curcumin	12-20	tensin 2	Mus musculus	155-158
21187084-11	2011	Furthermore, curcumin reduced the intracellular signaling proteins Ras, B-raf, p-MEK, p-ERK, c-fos, Egr-1, but increased Raf-1 and NAB2 in MDCK cells exposed to forskolin.	Curcumin	13-21	NGFI-A binding protein 2	Canis lupus familiaris	131-135
20938987-0	2011	Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: relevance for anti-aging intervention.	Curcumin	0-8	heme oxygenase 1	Homo sapiens	17-33
20153625-0	2010	Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention.	Curcumin	0-8	vitamin D receptor	Homo sapiens	54-72
20938987-2	2011	METHODS AND RESULTS: Early passage young human skin fibroblasts treated with low doses of curcumin (below 20 muM) showed a time- and concentration-dependent induction of heme oxygenase-1 (HO-1), followed by compensatory increase in glutathione-S-transferase activity, GSH levels and GSH/GSSG ratio.	Curcumin	90-98	heme oxygenase 1	Homo sapiens	170-186
20153625-3	2010	Using reporter gene and mammalian two-hybrid systems, immunoblotting, competitive ligand displacement and quantitative real-time PCR, we identified curcumin (CM), a turmeric-derived bioactive polyphenol, as a likely additional novel ligand for VDR.	Curcumin	148-156	vitamin D receptor	Homo sapiens	244-247
20938987-2	2011	METHODS AND RESULTS: Early passage young human skin fibroblasts treated with low doses of curcumin (below 20 muM) showed a time- and concentration-dependent induction of heme oxygenase-1 (HO-1), followed by compensatory increase in glutathione-S-transferase activity, GSH levels and GSH/GSSG ratio.	Curcumin	90-98	heme oxygenase 1	Homo sapiens	188-192
20938987-5	2011	The use of the antioxidant N-acetyl cysteine prevented the induction of HO-1 by curcumin.	Curcumin	80-88	heme oxygenase 1	Homo sapiens	72-76
20938987-6	2011	Pharmacological inhibition of phosphatidylinositol 3-kinase, but not other kinases, significantly prevented curcumin-induced HO-1 levels, which was corroborated by the induction of phospho-Akt levels by curcumin.	Curcumin	108-116	heme oxygenase 1	Homo sapiens	125-129
20840842-3	2010	We hypothesized whether altered neurite morphologies resulting from Abeta production had anything to do with the changes of expression of microtubule-associated protein 2 (MAP2), but curcumin could reverse damaged neurites by upregulation of MAP2 expression.	Curcumin	183-191	microtubule associated protein 2	Homo sapiens	242-246
20840842-5	2010	After screening the protective effect of curcumin and derivatives, we found that the viability of SK-N-SH cell model induced by Abeta1-42 was significantly increased by curcumin and Cur1, and the expression of MAP-2 protein was obviously up-regulated in immunocytochemical staining and Western blot.	Curcumin	41-49	microtubule associated protein 2	Homo sapiens	210-215
20938987-7	2011	Late passage senescent cells already had higher HO-1 levels, and further induction of HO-1 by curcumin was considerably impaired.	Curcumin	94-102	heme oxygenase 1	Homo sapiens	86-90
20840842-8	2010	Our study revealed for the first time that the neuroprotective effect of curcumin and curcumin derivatives not only directly depends on their special chemical constitution, but they can resist to Abeta damage by up-regulation of MAP-2 expression.	Curcumin	73-81	microtubule associated protein 2	Homo sapiens	229-234
21195127-11	2011	In conclusion, hyperglycemia stimulated HSC activation in vitro by increasing intracellular glucose, which was eliminated by curcumin by blocking the membrane translocation of GLUT2 and suppressing glut2 expression.	Curcumin	125-133	fucosyltransferase 1 (H blood group)	Homo sapiens	40-43
20840842-8	2010	Our study revealed for the first time that the neuroprotective effect of curcumin and curcumin derivatives not only directly depends on their special chemical constitution, but they can resist to Abeta damage by up-regulation of MAP-2 expression.	Curcumin	86-94	microtubule associated protein 2	Homo sapiens	229-234
20878089-10	2010	Curcumin induced the unfolding protein response by down-regulating the protein expressions of Calnexin, PDI and Ero1-Lalpha and up-regulating the Calreticulin expression.	Curcumin	0-8	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	112-123
21195127-13	2011	Our results presented evidence to impacts of hyperglycemia on stimulating HSC activation and hepatic fibrogenesis, and provided novel insights into the mechanisms by which curcumin eliminated the hyperglycemia-caused HSC activation and potential therapeutic strategies for treatment of diabetes-associated hepatic fibrogenesis.	Curcumin	172-180	fucosyltransferase 1 (H blood group)	Homo sapiens	74-77
19826913-4	2010	The objective of this study was to exam the curcumin cytotoxic effect and modulation of two major rate-limiting translation initiation factors, including eIF2alpha and eIF4E protein expression levels in lung adenocarcinoma epithelial cell line A549.	Curcumin	44-52	eukaryotic translation initiation factor 2A	Homo sapiens	154-163
21195127-13	2011	Our results presented evidence to impacts of hyperglycemia on stimulating HSC activation and hepatic fibrogenesis, and provided novel insights into the mechanisms by which curcumin eliminated the hyperglycemia-caused HSC activation and potential therapeutic strategies for treatment of diabetes-associated hepatic fibrogenesis.	Curcumin	172-180	fucosyltransferase 1 (H blood group)	Homo sapiens	217-220
19826913-9	2010	These findings suggest that curcumin could reduce cell viability through prohibiting the initiation of protein synthesis by modulating eIF2alpha and eIF4E.	Curcumin	28-36	eukaryotic translation initiation factor 2A	Homo sapiens	135-144
21427908-7	2011	And the dosage of 30 micromol x L(-1) curcumin could lead to the recruitment of alpha-tubulin.	Curcumin	38-46	tubulin alpha 1b	Homo sapiens	80-93
20885979-8	2010	We found Curcumin decreased the levels of D-lactate, DAO, MPO, ICAM-1, IL-1beta and TNF-alpha, but increased the levels of IL-10 and SOD in rat models.	Curcumin	9-17	intercellular adhesion molecule 1	Rattus norvegicus	63-69
20538607-3	2010	In addition, curcumin decreased expression of p50 and p65 proteins and NFkappaB-dependent transactivation and also decreased Sp1, Sp3, and Sp4 transcription factors that are overexpressed in pancreatic cancer cells.	Curcumin	13-21	Sp4 transcription factor	Homo sapiens	139-142
20538607-5	2010	Results of Sp1, Sp3, and Sp4 knockdown by RNA interference demonstrate that both p50 and p65 are Sp-regulated genes and that inhibition of constitutive or tumor necrosis factor-induced NFkappaB by curcumin is dependent on down-regulation of Sp1, Sp3, and Sp4 proteins by this compound.	Curcumin	197-205	Sp4 transcription factor	Homo sapiens	255-258
20848615-9	2011	CONCLUSION: We demonstrate the protective/preventive effect of curcumin in the progression of colorectal cancer associated to colitis, which was correlated with a lowered immunoreactivity of ss-catenin, a non-modification of p53 expression, a reduction of proinflammatory cytokine levels and a decrease of inflammatory protein overexpression.	Curcumin	63-71	transformation related protein 53, pseudogene	Mus musculus	225-228
20971552-6	2011	We show that Wnt inhibitors curcumin and quercetin target downstream beta-catenin activity and effectively repress HBx-mediated regulation of c-MYC and E-cadherin.	Curcumin	28-36	catenin beta 1	Homo sapiens	69-81
20395228-1	2010	Curcumin exerts a hypoglycemic action and induces heme-oxygenase-1 (HO-1).	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	50-66
20395228-1	2010	Curcumin exerts a hypoglycemic action and induces heme-oxygenase-1 (HO-1).	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	68-72
20395228-5	2010	Insulin secretion, HO-1 gene expression and HO activity were significantly increased in islets incubated in curcumin, hemin, and glucose compared with controls.	Curcumin	108-116	heme oxygenase 1	Rattus norvegicus	19-23
20971552-6	2011	We show that Wnt inhibitors curcumin and quercetin target downstream beta-catenin activity and effectively repress HBx-mediated regulation of c-MYC and E-cadherin.	Curcumin	28-36	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	142-147
20395228-7	2010	The action of curcumin on insulin secretion from the isolated islets may be, in part, mediated through increased HO-1 gene expression.	Curcumin	14-22	heme oxygenase 1	Rattus norvegicus	113-117
22146732-0	2011	Antioxidation and tyrosinase inhibition of polyphenolic curcumin analogs.	Curcumin	56-64	tyrosinase	Mus musculus	18-28
20561944-6	2010	From this, curcumin treatment strongly induced glucose uptake and the phosphorylation of AMPK (AMP-activated protein kinase)/ACC (acetyl-CoA carboxylase), but not PI3-kinase (phosphoinositide 3-kinase)/Akt.	Curcumin	11-19	anterior capsular cataract	Mus musculus	125-128
20561944-7	2010	Interestingly, the co-treatment of insulin and curcumin produced a mutual synergistic activation of both AMPK/ACC and PI3-kinase/Akt pathways.	Curcumin	47-55	anterior capsular cataract	Mus musculus	110-113
22146732-1	2011	A series of polyphenolic curcumin analogs were synthesized and their inhibitory effects on mushroom tyrosinase and the inhibition of 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical formation were evaluated.	Curcumin	25-33	tyrosinase	Mus musculus	100-110
22146732-4	2011	These results suggest that such polyphenolic curcumin analogs might serve as lead compounds for further design of new potential tyrosinase inhibitors.	Curcumin	45-53	tyrosinase	Mus musculus	128-138
20305684-10	2010	Curcumin, however, inhibited the suppressive activity of Treg cells by downregulating the production of TGF-beta and IL-10 in these cells.	Curcumin	0-8	interleukin 10	Homo sapiens	117-122
21069258-1	2011	The aim of this study was to observe the inhibitory effect of curcumin on endometriosis (EMS) and to determine its influence on vascular endothelial growth factor (VEGF) and microvessel density (MVD) in eutopic and ectopic endometrium of experimental rats, thus exploring the pathogenesis of EMS offering more experimental evidence for the clinical use of curcumin.	Curcumin	62-70	vascular endothelial growth factor A	Rattus norvegicus	164-168
20514428-4	2010	In addition, the expression of melanogenesis-related proteins such as microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein 1 and 2 was suppressed by curcumin in the alpha-MSH-stimulated B16F10 cells.	Curcumin	194-202	tyrosinase-related protein 1	Mus musculus	141-175
20302927-9	2010	Treatment with the AP1 inhibitor curcumin prevented H(2)O(2)-mediated reductions in PPAR gamma expression.	Curcumin	33-41	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	19-22
21069258-8	2011	There was an increase in MVD and VEGF in the ectopic endometrium, which was decreased significantly after treatment with curcumin (P&lt;0.05); the effects being dose-dependent.	Curcumin	121-129	vascular endothelial growth factor A	Rattus norvegicus	33-37
21069258-11	2011	Curcumin decreased the quantity of microvessels and VEGF protein expression in the heterotopic endometrium of rats with EMS.	Curcumin	0-8	vascular endothelial growth factor A	Rattus norvegicus	52-56
20484172-3	2010	OBJECTIVE: To investigate the effect of curcumin on the activities of CYP1A2, CYP2A6, N-acetyltransferase (NAT2), and xanthine oxidase (XO) in vivo, using caffeine as a probe drug.	Curcumin	40-48	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	78-84
20484172-3	2010	OBJECTIVE: To investigate the effect of curcumin on the activities of CYP1A2, CYP2A6, N-acetyltransferase (NAT2), and xanthine oxidase (XO) in vivo, using caffeine as a probe drug.	Curcumin	40-48	N-acetyltransferase 2	Homo sapiens	107-111
21857083-8	2011	In addition, curcumin significantly decreased p38MAPK and phospho-CDC-2 protein expression and increased phospho-p38MAPK, p42/44MAPK, and phospho-p42/44MAPK protein expression.	Curcumin	13-21	cyclin dependent kinase 1	Homo sapiens	66-71
20651361-6	2010	After curcumin treatment, BAX and BAD were up-regulated, BCL-2, BCL-X(L) and XIAP were down-regulated.	Curcumin	6-14	X-linked inhibitor of apoptosis	Homo sapiens	77-81
21858029-9	2011	0.05% curcumin pre-treatment inhibited I/R-induced degeneration of retinal capillaries, TUNEL-positive apoptotic cell death in the GCL, brn3a stained cell loss, the I/R-induced up-regulation of MCP-1, IKKalpha, p-IkappaBalpha and p-STAT3 (Tyr), and down-regulation of beta-tubulin III.	Curcumin	6-14	POU class 4 homeobox 1	Rattus norvegicus	136-141
21858029-9	2011	0.05% curcumin pre-treatment inhibited I/R-induced degeneration of retinal capillaries, TUNEL-positive apoptotic cell death in the GCL, brn3a stained cell loss, the I/R-induced up-regulation of MCP-1, IKKalpha, p-IkappaBalpha and p-STAT3 (Tyr), and down-regulation of beta-tubulin III.	Curcumin	6-14	component of inhibitor of nuclear factor kappa B kinase complex	Rattus norvegicus	201-209
20565374-1	2010	OBJECTIVES: In this study, we assessed the immunosuppressive potential of curcumin, a pharmacologically safe and cost-effective naturally occurring polyphenolic phytochemical, on the induction of Th1 cytokines that are frequently overexpressed in patients experiencing rejection after renal transplant.	Curcumin	74-82	negative elongation factor complex member C/D	Homo sapiens	196-199
21858029-9	2011	0.05% curcumin pre-treatment inhibited I/R-induced degeneration of retinal capillaries, TUNEL-positive apoptotic cell death in the GCL, brn3a stained cell loss, the I/R-induced up-regulation of MCP-1, IKKalpha, p-IkappaBalpha and p-STAT3 (Tyr), and down-regulation of beta-tubulin III.	Curcumin	6-14	signal transducer and activator of transcription 3	Rattus norvegicus	232-237
20565374-8	2010	CONCLUSIONS: These data provide a rationale for the use of curcumin as an affordable, pharmacologically safe, adjuvant immunosuppressant when used with cyclosporine and suggest that curcumin can effectively suppress Th1 cytokine induction after renal transplant.	Curcumin	59-67	negative elongation factor complex member C/D	Homo sapiens	216-219
20565374-8	2010	CONCLUSIONS: These data provide a rationale for the use of curcumin as an affordable, pharmacologically safe, adjuvant immunosuppressant when used with cyclosporine and suggest that curcumin can effectively suppress Th1 cytokine induction after renal transplant.	Curcumin	182-190	negative elongation factor complex member C/D	Homo sapiens	216-219
20205235-4	2010	In addition, curcumin activated the mitogen-activated protein kinase kinase (MEK)3/6-p38 mitogen-activated protein kinase (MAPK) signaling pathways in the downstream of the AMPK cascade.	Curcumin	13-21	mitogen-activated protein kinase kinase 3	Homo sapiens	77-82
21858029-13	2011	The beneficial effects of curcumin on neurovascular degeneration may occur through its inhibitory effects on injury-induced activation of NF-kappaB and STAT3, and on over-expression of MCP-1.	Curcumin	26-34	signal transducer and activator of transcription 3	Rattus norvegicus	152-157
20937840-7	2010	The NF-kappaB inhibitors curcumin, pyrrolidine dithiocarbamate or CAY10512 abrogated both IRAK-2 and miRNA-146a expression, whereas IRAK-1 was up-regulated.	Curcumin	25-33	microRNA 146a	Homo sapiens	101-111
21311680-6	2010	Expression of several genes, cyclin A, p21, and p27, which has been shown to be regulated in E2F4-dependent manner and involved in the cell cycle progression was also affected by curcumin.	Curcumin	179-187	H3 histone pseudogene 16	Homo sapiens	39-42
21311680-6	2010	Expression of several genes, cyclin A, p21, and p27, which has been shown to be regulated in E2F4-dependent manner and involved in the cell cycle progression was also affected by curcumin.	Curcumin	179-187	interferon alpha inducible protein 27	Homo sapiens	48-51
20346917-7	2010	These results suggested that curcumin dramatically enhances RA-induced O(2)(-)-generating activity via accumulation of cytosolic p47-phox and p67-phox proteins in U937 cells.	Curcumin	29-37	neutrophil cytosolic factor 1	Homo sapiens	129-137
21311680-7	2010	Moreover, decreased (cyclin A) and increased (p21 and p27) expression of these E2F4 downstream genes by curcumin was restored by pretreatment of cells with NAC and E2F4 overexpression which is induced by doxycycline.	Curcumin	104-112	H3 histone pseudogene 16	Homo sapiens	46-49
20133951-10	2010	Significant differences in inhibitory potency of curcumin against PG- vs. IGF-II-stimulated growth of IEC-18 cells were not reflected by differences in curcumin-mediated inhibition of activated (phosphorylated) ERKs/IKK(alpha/beta)/p65NF-kappaB and c-Src in wild-type (wt)IEC-18 cells, in response to the two growth factors.	Curcumin	49-57	insulin-like growth factor 2	Rattus norvegicus	74-80
21311680-7	2010	Moreover, decreased (cyclin A) and increased (p21 and p27) expression of these E2F4 downstream genes by curcumin was restored by pretreatment of cells with NAC and E2F4 overexpression which is induced by doxycycline.	Curcumin	104-112	interferon alpha inducible protein 27	Homo sapiens	54-57
20145189-7	2010	In the immortalized, leukoplakia, and cancer cells, curcumin inhibited cap-dependent translation by suppressing the phosphorylation of 4E-BP1, eIF4G, eIF4B, and Mnk1, and also reduced the total levels of eIF4E and Mnk1.	Curcumin	52-60	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	143-148
20145189-7	2010	In the immortalized, leukoplakia, and cancer cells, curcumin inhibited cap-dependent translation by suppressing the phosphorylation of 4E-BP1, eIF4G, eIF4B, and Mnk1, and also reduced the total levels of eIF4E and Mnk1.	Curcumin	52-60	MAPK interacting serine/threonine kinase 1	Homo sapiens	161-165
21328975-0	2010	[Effect of curcumine on the nuclear pathway of JNK during hippocampal ischemia/reperfusion injury in SHR].	Curcumin	11-20	mitogen-activated protein kinase 8	Rattus norvegicus	47-50
20145189-7	2010	In the immortalized, leukoplakia, and cancer cells, curcumin inhibited cap-dependent translation by suppressing the phosphorylation of 4E-BP1, eIF4G, eIF4B, and Mnk1, and also reduced the total levels of eIF4E and Mnk1.	Curcumin	52-60	MAPK interacting serine/threonine kinase 1	Homo sapiens	214-218
21302394-0	2010	Effect of curcumin on vascular endothelial growth factor expression in diabetic mice kidney induced by streptozotocin.	Curcumin	10-18	vascular endothelial growth factor A	Mus musculus	22-56
21302394-1	2010	OBJECTIVE: To localize and demonstrate the effect of curcumin on vascular endothelial growth factor in diabetic mice kidney induced by streptozotocin.	Curcumin	53-61	vascular endothelial growth factor A	Mus musculus	65-99
21328975-1	2010	OBJECTIVE: To investigate the diversify of the nuclear pathway of c-Jun NH2-terminal kinases (JNK) during transient brain ischemia/reperfusion injury in hippocampal neuron apoptosis in spontaneously hypertensive rats (SHR) and to test whether the neuroprotection of curcumine on transient brain ischemia/reperfusion injury in SHR is related to the nuclear pathway of JNK.	Curcumin	266-275	mitogen-activated protein kinase 8	Rattus norvegicus	66-92
21302394-9	2010	Treatment with curcumin significantly inhibited the expression of VEGF in the kidney tissue of diabetic mice in both 4 and 8 weeks.	Curcumin	15-23	vascular endothelial growth factor A	Mus musculus	66-70
21328975-1	2010	OBJECTIVE: To investigate the diversify of the nuclear pathway of c-Jun NH2-terminal kinases (JNK) during transient brain ischemia/reperfusion injury in hippocampal neuron apoptosis in spontaneously hypertensive rats (SHR) and to test whether the neuroprotection of curcumine on transient brain ischemia/reperfusion injury in SHR is related to the nuclear pathway of JNK.	Curcumin	266-275	mitogen-activated protein kinase 8	Rattus norvegicus	94-97
20406252-6	2010	In in vivo studies, oral administration of curcumin has resulted in the inhibition of Abeta deposition, Abeta oligomerization, and tau phosphorylation in the brains of AD animal models, and improvements in behavioral impairment in animal models.	Curcumin	43-51	microtubule associated protein tau	Homo sapiens	131-134
20605902-4	2010	Curcumin plus ATO or lonidamine stimulates typical events of the mitochondrial executioner pathway (Bax and Bid activation, cytochrome c release, X-linked inhibitor of apoptosis down-regulation, and caspase-9/-3 activation) and causes mitochondrial transmembrane potential dissipation, which nevertheless represents a late event in the apoptotic response.	Curcumin	0-8	caspase 9	Homo sapiens	199-208
20043100-10	2010	GSH and NAC, an anti-oxidant agent, blocked the curcumin-induced ROS production, MMP loss and rescued cells from curcumin-induced apoptosis.	Curcumin	113-121	X-linked Kx blood group	Homo sapiens	8-11
20937593-0	2010	Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma via inhibition of IKKbeta protein of the NFkappaB pathway.	Curcumin	0-8	inhibitor of kappaB kinase beta	Mus musculus	116-123
20230279-0	2010	Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway.	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	72-95
20937593-5	2010	Reduced expression of cyclin D1, IkappaBalpha, phospho-IkappaBalpha, and IKKbeta occurred in cisplatin- and curcumin-treated cell lines.	Curcumin	108-116	inhibitor of kappaB kinase beta	Mus musculus	73-80
20230279-5	2010	Most importantly, curcumin treatment significantly inhibited MPTP/MPP(+)-induced phosphorylation of JNK1/2 and c-Jun, and cleaved caspase-3.	Curcumin	18-26	mitogen-activated protein kinase 8	Mus musculus	100-106
20937593-8	2010	Curcumin inhibited IKKbeta in the cytoplasm and nucleus, leading to reduced NFkappaB activity, with no effect on phospho-AKT.	Curcumin	0-8	inhibitor of kappaB kinase beta	Mus musculus	19-26
20230279-6	2010	Our study suggests that the neuroprotective effect of curcumin is not related simply to its antiinflammatory and antioxidant properties, but involves other mechanisms, particularly by targeting the JNK pathways.	Curcumin	54-62	mitogen-activated protein kinase 8	Mus musculus	198-201
20937593-10	2010	The suppressive effect of curcumin was mediated through inhibition of cytoplasmic and nuclear IKKbeta, resulting in inhibition of NFkappaB activity.	Curcumin	26-34	inhibitor of kappaB kinase beta	Mus musculus	94-101
20885979-0	2010	Curcumin protects intestinal mucosal barrier function of rat enteritis via activation of MKP-1 and attenuation of p38 and NF-kappaB activation.	Curcumin	0-8	dual specificity phosphatase 1	Rattus norvegicus	89-94
20622013-0	2010	Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.	Curcumin	0-8	amyloid beta (A4) precursor protein	Mus musculus	80-110
20224684-0	2010	Investigation of interaction of vaccinia virus complement control protein and curcumin with complement components c3 and c3b using quartz crystal microbalance with dissipation monitoring technology.	Curcumin	78-86	complement C3	Homo sapiens	121-124
20594343-9	2010	In IL-1beta stimulated co-cultures, four-hour pre-treatment with curcumin significantly enhanced the production of collagen type II, cartilage specific proteoglycans (CSPGs), beta1-integrin, as well as activating MAPKinase signaling and suppressing caspase-3 and cyclooxygenase-2.	Curcumin	65-73	integrin subunit beta 1	Homo sapiens	175-189
20513444-8	2010	Both Tyrphostin AG1478, an EGFR tyrosine kinase inhibitor, and curcumin, an inhibitor of both STAT3 and EGFR, attenuated STAT3 activation/nuclear translocation, reduced skin thickening, and partially suppressed the barrier abnormalities.	Curcumin	63-71	epidermal growth factor receptor	Mus musculus	104-108
20646066-5	2010	Curcumin also perturbed the localization of the kinesin protein Eg5 and induced monopolar spindle formation.	Curcumin	0-8	kinesin family member 11	Homo sapiens	64-67
20646066-6	2010	Further, curcumin increased the accumulation of Mad2 and BubR1 at the kinetochores, indicating that it activated the mitotic checkpoint.	Curcumin	9-17	mitotic arrest deficient 2 like 1	Homo sapiens	48-52
20646066-6	2010	Further, curcumin increased the accumulation of Mad2 and BubR1 at the kinetochores, indicating that it activated the mitotic checkpoint.	Curcumin	9-17	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	57-62
20399909-0	2010	COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone marrow-derived dendritic cells.	Curcumin	78-86	indoleamine 2,3-dioxygenase 1	Mus musculus	60-63
20399909-2	2010	In this study we show that curcumin inhibits IDO expression in vitro and in vivo in DCs, leading to the suppression of LPS-induced DC maturation.	Curcumin	27-35	indoleamine 2,3-dioxygenase 1	Mus musculus	45-48
20399909-5	2010	Under our experimental conditions, curcumin plays an immunomodulatory role by downregulating IDO expression via a COX-2/PGE2-dependant pathway, thus impacting DC maturation in vitro and in vivo.	Curcumin	35-43	indoleamine 2,3-dioxygenase 1	Mus musculus	93-96
19744483-6	2010	Additional small-molecule inhibitors, including polyphenolic compounds such as curcumin, (-)-epigallocatechin gallate (EGCG), and grape seed extract have been shown to attenuate Abeta aggregation through distinct mechanisms, and have shown effectiveness at reducing amyloid levels when administered to transgenic mouse models of AD.	Curcumin	79-87	amyloid beta (A4) precursor protein	Mus musculus	178-183
20363232-6	2010	Using Western blot and RT-PCR, human telomerase reverse transcriptase (hTERT) decreased in the presence of curcumin.	Curcumin	107-115	telomerase reverse transcriptase	Homo sapiens	71-76
20363232-9	2010	In addition, NAC blunted the Sp1 reduction and hTERT downregulation by curcumin.	Curcumin	71-79	telomerase reverse transcriptase	Homo sapiens	47-52
20363232-10	2010	Further, reporter assay and DNA affinity precipitation assay confirmed the influence of curcumin on Sp1 in hTERT regulation.	Curcumin	88-96	telomerase reverse transcriptase	Homo sapiens	107-112
20363232-11	2010	This is the first study to demonstrate that curcumin induces ROS production resulting in Sp1 binding activity inhibition and hTERT downregulation.	Curcumin	44-52	telomerase reverse transcriptase	Homo sapiens	125-130
20188213-8	2010	The results showed that compared with untreated CIA mice, curcumin-treated mice downregulated clinical arthritis score, the proliferation of splenic T cells, expression levels of TNF-alpha and IL-1beta in the ankle joint, and expression levels of IgG2a in serum.	Curcumin	58-66	immunoglobulin heavy variable V1-9	Mus musculus	247-252
20372842-9	2010	Caspases activation during the course of curcumin-induced apoptosis was additionally confirmed by using a broad-spectrum caspases inhibitor, Z-VAD-fmk.	Curcumin	41-49	caspase 9	Homo sapiens	0-8
20403165-0	2010	Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression.	Curcumin	0-8	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	75-81
20403165-3	2010	Previous in vivo studies showed that administration of curcumin also decreased cholesterol levels in the blood, and the effects were considered to be related to upregulation of LDL receptor.	Curcumin	55-63	low density lipoprotein receptor	Homo sapiens	177-189
20403165-4	2010	However, since plasma cholesterol levels are also influenced by the uptake of cholesterol in the gut, which is mediated by a specific transporter Niemann-Pick Cl-like 1 (NPC1L1) protein, the present study is to investigate whether curcumin affects cholesterol uptake in the intestinal Caco-2 cells.	Curcumin	231-239	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	170-176
20403165-9	2010	Finally we determined whether curcumin affects the expression of NPC1L1 by both Western blot analysis and qPCR quantification.	Curcumin	30-38	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	65-71
20403165-13	2010	In addition, we found that the curcumin-induced inhibition of cholesterol uptake was associated with significant decrease in the levels of NPC1L1 protein and NPC1L1 mRNA, as analyzed by Western blot and qPCR, respectively.	Curcumin	31-39	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	139-145
20403165-13	2010	In addition, we found that the curcumin-induced inhibition of cholesterol uptake was associated with significant decrease in the levels of NPC1L1 protein and NPC1L1 mRNA, as analyzed by Western blot and qPCR, respectively.	Curcumin	31-39	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	158-164
20403165-14	2010	CONCLUSION: Curcumin inhibits cholesterol uptake through suppression of NPC1L1 expression in the intestinal cells.	Curcumin	12-20	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	72-78
19751963-0	2010	Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT.	Curcumin	0-8	heat shock protein 90 alpha family class A member 1	Homo sapiens	73-78
19751963-0	2010	Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT.	Curcumin	0-8	prostaglandin E synthase 3	Homo sapiens	92-95
19751963-0	2010	Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT.	Curcumin	0-8	telomerase reverse transcriptase	Homo sapiens	101-106
19751963-3	2010	Here we demonstrate that curcumin inhibits telomerase activity in a time- and dose-dependent manner by decreasing the level of hTERT expression.	Curcumin	25-33	telomerase reverse transcriptase	Homo sapiens	127-132
19751963-4	2010	Following curcumin treatment, we observed a clear accumulation of hTERT in the cytoplasmic compartment of the cell.	Curcumin	10-18	telomerase reverse transcriptase	Homo sapiens	66-71
19751963-5	2010	The curcumin-induced cytoplasmic retention of hTERT could be due to failure of nuclear import, and the resulting cytoplasmic hTERT protein was rapidly ubiquitinated and degraded by the proteasome.	Curcumin	4-12	telomerase reverse transcriptase	Homo sapiens	46-51
19751963-5	2010	The curcumin-induced cytoplasmic retention of hTERT could be due to failure of nuclear import, and the resulting cytoplasmic hTERT protein was rapidly ubiquitinated and degraded by the proteasome.	Curcumin	4-12	telomerase reverse transcriptase	Homo sapiens	125-130
19751963-6	2010	We also report that curcumin treatment results in a substantial decrease in association of p23 and hTERT but does not affect the Hsp90 binding to hTERT.	Curcumin	20-28	prostaglandin E synthase 3	Homo sapiens	91-94
19751963-6	2010	We also report that curcumin treatment results in a substantial decrease in association of p23 and hTERT but does not affect the Hsp90 binding to hTERT.	Curcumin	20-28	telomerase reverse transcriptase	Homo sapiens	99-104
19751963-8	2010	Taken together, these results demonstrate that the interaction of the Hsp90-p23 complex with hTERT is critical for regulation of the nuclear localization of telomerase, and that down-regulation of hTERT by curcumin involves dissociating the binding of hTERT with p23.	Curcumin	206-214	telomerase reverse transcriptase	Homo sapiens	197-202
19751963-8	2010	Taken together, these results demonstrate that the interaction of the Hsp90-p23 complex with hTERT is critical for regulation of the nuclear localization of telomerase, and that down-regulation of hTERT by curcumin involves dissociating the binding of hTERT with p23.	Curcumin	206-214	telomerase reverse transcriptase	Homo sapiens	197-202
19751963-8	2010	Taken together, these results demonstrate that the interaction of the Hsp90-p23 complex with hTERT is critical for regulation of the nuclear localization of telomerase, and that down-regulation of hTERT by curcumin involves dissociating the binding of hTERT with p23.	Curcumin	206-214	prostaglandin E synthase 3	Homo sapiens	263-266
19751963-9	2010	Thus, inhibition of nuclear translocation of hTERT by curcumin may provide new perspectives for regulation of telomerase activity during tumorigenic progression.	Curcumin	54-62	telomerase reverse transcriptase	Homo sapiens	45-50
20054649-4	2010	Curcumin supplementation to MNU treated mice was able to reduce significantly the activities of the G6P, G6I, hexokinase, LDH, SDH and increased the glycogen contents in both the regions of brain which were altered following MNU treatment.	Curcumin	0-8	aminoadipate-semialdehyde synthase	Mus musculus	127-130
20071421-9	2010	Interestingly, the lead-induced upregulation of GRP78 and GRP94 was almost completely blocked by the JNK inhibitor SP600125 or activator protein-1 (AP-1) inhibitor curcumin.	Curcumin	164-172	Jun proto-oncogene, AP-1 transcription factor subunit	Bos taurus	127-146
20071421-9	2010	Interestingly, the lead-induced upregulation of GRP78 and GRP94 was almost completely blocked by the JNK inhibitor SP600125 or activator protein-1 (AP-1) inhibitor curcumin.	Curcumin	164-172	Jun proto-oncogene, AP-1 transcription factor subunit	Bos taurus	148-152
20071071-0	2010	Binding of curcumin with glyoxalase I: Molecular docking, molecular dynamics simulations, and kinetics analysis.	Curcumin	11-19	glyoxalase I	Homo sapiens	25-37
20071071-2	2010	Recent studies demonstrate that the nature product curcumin is an efficient inhibitor of GLOI, but its binding mechanism towards GLOI is still unclear.	Curcumin	51-59	glyoxalase I	Homo sapiens	89-93
20071071-2	2010	Recent studies demonstrate that the nature product curcumin is an efficient inhibitor of GLOI, but its binding mechanism towards GLOI is still unclear.	Curcumin	51-59	glyoxalase I	Homo sapiens	129-133
20071071-3	2010	In the present study, molecular docking and molecular dynamics (MD) simulations were performed to better understand the inhibitory mechanism of curcumin towards GLOI.	Curcumin	144-152	glyoxalase I	Homo sapiens	161-165
20071071-4	2010	The enol form of curcumin coordinates with the catalytic zinc ion of GLOI and forms a strong hydrogen bond with Glu 172, whereas its keto tautomer displays unfavorable electrostatic interactions with Glu 172 and Glu 99.	Curcumin	17-25	glyoxalase I	Homo sapiens	69-73
20734924-0	2010	Anti-breast cancer activity of curcumin on the human oxidation-resistant cells ZR-75-1 with gamma-glutamyltranspeptidase inhibition.	Curcumin	31-39	inactive glutathione hydrolase 2	Homo sapiens	92-120
20734924-5	2010	The GGTP activity was decreased in a dose-dependent manner by curcumin, with the changes in this parameter accounting for neoplastic inhibition (direct relation between the enzyme activity and cellular viability).	Curcumin	62-70	inactive glutathione hydrolase 2	Homo sapiens	4-8
20036734-4	2010	The levels of AIP-1/Alix protein, a known inhibitor protein of paraptosis, were progressively downregulated in curcumin-treated malignant breast cancer cells, and AIP-1/Alix overexpression attenuated curcumin-induced death in these cells.	Curcumin	111-119	programmed cell death 6 interacting protein	Homo sapiens	14-19
20734924-6	2010	Summing up, our results suggest that curcumin induced apoptosis in ZR-75-1 with an antioxidant activity performed on those treated with copper(II) sulphate, which should be explored more thoroughly with the involvement of the GGTP enzyme activity as biomarker of their malignancy.	Curcumin	37-45	inactive glutathione hydrolase 2	Homo sapiens	226-230
20036734-4	2010	The levels of AIP-1/Alix protein, a known inhibitor protein of paraptosis, were progressively downregulated in curcumin-treated malignant breast cancer cells, and AIP-1/Alix overexpression attenuated curcumin-induced death in these cells.	Curcumin	111-119	programmed cell death 6 interacting protein	Homo sapiens	20-24
20036734-4	2010	The levels of AIP-1/Alix protein, a known inhibitor protein of paraptosis, were progressively downregulated in curcumin-treated malignant breast cancer cells, and AIP-1/Alix overexpression attenuated curcumin-induced death in these cells.	Curcumin	111-119	programmed cell death 6 interacting protein	Homo sapiens	169-173
20036734-4	2010	The levels of AIP-1/Alix protein, a known inhibitor protein of paraptosis, were progressively downregulated in curcumin-treated malignant breast cancer cells, and AIP-1/Alix overexpression attenuated curcumin-induced death in these cells.	Curcumin	200-208	programmed cell death 6 interacting protein	Homo sapiens	14-19
20036734-4	2010	The levels of AIP-1/Alix protein, a known inhibitor protein of paraptosis, were progressively downregulated in curcumin-treated malignant breast cancer cells, and AIP-1/Alix overexpression attenuated curcumin-induced death in these cells.	Curcumin	200-208	programmed cell death 6 interacting protein	Homo sapiens	20-24
20036734-4	2010	The levels of AIP-1/Alix protein, a known inhibitor protein of paraptosis, were progressively downregulated in curcumin-treated malignant breast cancer cells, and AIP-1/Alix overexpression attenuated curcumin-induced death in these cells.	Curcumin	200-208	programmed cell death 6 interacting protein	Homo sapiens	163-168
20036734-4	2010	The levels of AIP-1/Alix protein, a known inhibitor protein of paraptosis, were progressively downregulated in curcumin-treated malignant breast cancer cells, and AIP-1/Alix overexpression attenuated curcumin-induced death in these cells.	Curcumin	200-208	programmed cell death 6 interacting protein	Homo sapiens	169-173
20025076-0	2010	Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells.	Curcumin	0-8	sonic hedgehog signaling molecule	Homo sapiens	22-36
20025076-5	2010	Moreover, curcumin inhibited the Shh-Gli1 signaling pathway by downregulating the Shh protein and its most important downstream targets GLI1 and PTCH1.	Curcumin	10-18	sonic hedgehog signaling molecule	Homo sapiens	33-36
20025076-5	2010	Moreover, curcumin inhibited the Shh-Gli1 signaling pathway by downregulating the Shh protein and its most important downstream targets GLI1 and PTCH1.	Curcumin	10-18	sonic hedgehog signaling molecule	Homo sapiens	82-85
20025076-6	2010	Furthermore, curcumin reduced the levels of beta-catenin, the activate/phosphorylated form of Akt and NF-kappaB, which led to downregulating the three common key effectors, namely C-myc, N-myc, and Cyclin D1.	Curcumin	13-21	catenin beta 1	Homo sapiens	44-56
20025076-6	2010	Furthermore, curcumin reduced the levels of beta-catenin, the activate/phosphorylated form of Akt and NF-kappaB, which led to downregulating the three common key effectors, namely C-myc, N-myc, and Cyclin D1.	Curcumin	13-21	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	180-185
20025076-6	2010	Furthermore, curcumin reduced the levels of beta-catenin, the activate/phosphorylated form of Akt and NF-kappaB, which led to downregulating the three common key effectors, namely C-myc, N-myc, and Cyclin D1.	Curcumin	13-21	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	187-192
20025076-7	2010	Consequently, apoptosis was triggered by curcumin through the mitochondrial pathway via downregulation of Bcl-2, a downstream anti-apoptotic effector of the Shh signaling.	Curcumin	41-49	sonic hedgehog signaling molecule	Homo sapiens	157-160
20025076-8	2010	Importantly, the resistant cells that exhibited no decrease in the levels of Shh and Bcl-2, were sensitized to curcumin by the addition of the Shh antagonist, cyclopamine.	Curcumin	111-119	sonic hedgehog signaling molecule	Homo sapiens	143-146
20025076-12	2010	These results indicate that curcumin, a natural nontoxic compound, represents great promise as Shh-targeted therapy for medulloblastomas.	Curcumin	28-36	sonic hedgehog signaling molecule	Homo sapiens	95-98
20127004-0	2010	Curcumin blocks migration and invasion of mouse-rat hybrid retina ganglion cells (N18) through the inhibition of MMP-2, -9, FAK, Rho A and Rock-1 gene expression.	Curcumin	0-8	protein tyrosine kinase 2	Rattus norvegicus	124-127
20015472-6	2010	RESULTS: Dietary curcumin enhanced GSHT (p&lt;0.001) and UGT1A1 (p&lt;0.05) activity and significantly reduced the activity of CYP1A1 (p&lt;0.001), in rats exposed to aflatoxin B(1).	Curcumin	17-25	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	127-133
19944674-0	2010	Expression analysis of maspin in invasive ductal carcinoma of breast and modulation of its expression by curcumin in breast cancer cell lines.	Curcumin	105-113	serpin family B member 5	Homo sapiens	23-29
19944674-7	2010	Curcumin inhibited cell growth, induced apoptosis and upregulated maspin gene expression in MCF-7 cells and these findings were further correlated with the upregulation of p53 protein and downregulation of Bcl-2, suggesting maspin mediated apoptosis in MCF-7 cells.	Curcumin	0-8	serpin family B member 5	Homo sapiens	66-72
21086748-7	2010	Our results thus demonstrated the protective role of curcumin and ferulic acid on DMBA-induced abnormal expression of p53 and bcl-2 proteins in the buccal mucosa of golden Syrian hamsters.	Curcumin	53-61	cellular tumor antigen p53	Mesocricetus auratus	118-121
20199731-6	2010	TNF-alpha and IL-10 concentrations in the NEC model and the curcumin intervention groups increased significantly compared with those in the normal and solvent control groups (p&lt;0.05).	Curcumin	60-68	interleukin 10	Rattus norvegicus	14-19
20199731-7	2010	The concentration of TNF-alpha decreased (p&lt;0.05), while the concentration of IL-10 increased significantly in the curcumin intervention group in comparison with the NEC model group (p&lt;0.05).	Curcumin	118-126	interleukin 10	Rattus norvegicus	81-86
20199731-9	2010	CONCLUSIONS: Curcumin has protective effects against NEC in neonatal rats, possibly through inhibiting COX-2 expression, reducing TNF-alpha content, and increasing IL-10 content.	Curcumin	13-21	interleukin 10	Rattus norvegicus	164-169
19879924-0	2010	Curcumin exposure induces expression of the Parkinson"s disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells.	Curcumin	0-8	leucine-rich repeat kinase 2	Rattus norvegicus	75-103
19879924-0	2010	Curcumin exposure induces expression of the Parkinson"s disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells.	Curcumin	0-8	leucine-rich repeat kinase 2	Rattus norvegicus	105-110
19879924-7	2010	Here, we report that exposure of rat mesencephalic cells to curcumin induces the expression of LRRK2 mRNA and protein in a time-dependent manner.	Curcumin	60-68	leucine-rich repeat kinase 2	Rattus norvegicus	95-100
19879924-9	2010	As LRRK2 overexpression is strongly associated with the pathological inclusions found in several neurodegenerative disorders, further studies are needed to evaluate the effects of curcumin as a therapeutic agent for neurodegenerative diseases.	Curcumin	180-188	leucine-rich repeat kinase 2	Rattus norvegicus	3-8
20387230-7	2010	The cytotoxic effect of curcumin on SAS/luc cells was mainly at G2/M phase and a significant dose dependent increase of the apoptotic SAS/luc cells as represented by sub-G1 phase was shown.	Curcumin	24-32	tetraspanin 31	Homo sapiens	36-39
20387230-7	2010	The cytotoxic effect of curcumin on SAS/luc cells was mainly at G2/M phase and a significant dose dependent increase of the apoptotic SAS/luc cells as represented by sub-G1 phase was shown.	Curcumin	24-32	tetraspanin 31	Homo sapiens	134-137
20160437-5	2010	RESULTS: Curcumin inhibited TGF-beta(1)-induced plasminogen activator inhibitor-1 (PAI-1), alpha-smooth muscle actin (alpha-SMA) mRNA and protein expression.	Curcumin	9-17	serpin family E member 1	Homo sapiens	83-88
20686221-9	2010	Moreover, curcumin induced the expression of cyclin dependent kinase inhibitor genes p21 and p27, while it inhibited the expression of numerous genes, including Bcl-2, cyclin D1, CDK2, CDK4 and CDK6.	Curcumin	10-18	interferon alpha inducible protein 27	Homo sapiens	93-96
19629015-3	2010	We furthermore showed that curcumin, an Indian spice derived from the turmeric root, specifically inhibits MPA-induced VEGF secretion from breast cancer cells in vitro.	Curcumin	27-35	vascular endothelial growth factor A	Rattus norvegicus	119-123
19629015-10	2010	Immunohistochemical analyses of mammary tumors showed that curcumin decreased MPA-induced VEGF induction in hyperplastic lesions, although it did not affect the levels of estrogen and progesterone receptors.	Curcumin	59-67	vascular endothelial growth factor A	Rattus norvegicus	90-94
20358476-2	2010	To determine the mechanism of curcumin-induced cytotoxicity in prostate cancer cells, we exposed PC3 prostate carcinoma cells to 25 to 100 microM curcumin for 24 to 72 h. Curcumin treatment of PC3 cells caused time- and dose-dependent induction of apoptosis and depletion of cellular reduced glutathione (GSH).	Curcumin	30-38	chromobox 8	Homo sapiens	193-196
20358476-2	2010	To determine the mechanism of curcumin-induced cytotoxicity in prostate cancer cells, we exposed PC3 prostate carcinoma cells to 25 to 100 microM curcumin for 24 to 72 h. Curcumin treatment of PC3 cells caused time- and dose-dependent induction of apoptosis and depletion of cellular reduced glutathione (GSH).	Curcumin	171-179	chromobox 8	Homo sapiens	193-196
20358476-3	2010	Exogenous GSH and its precursor N-acetyl-cysteine, but not ascorbic acid (AA) or ebselen, decreased curcumin accumulation in PC3 cells and also prevented curcumin-induced DNA fragmentation.	Curcumin	100-108	chromobox 8	Homo sapiens	125-128
20358476-5	2010	Curcumin-treated PC3 cells showed apoptosis-inducing cellular ceramide accumulation and activation of p38 mitogen-activated protein kinase (MAPK) and c-jun N-terminal kinase (JNK).	Curcumin	0-8	chromobox 8	Homo sapiens	17-20
20661831-5	2010	Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak).	Curcumin	15-23	caspase 9	Homo sapiens	112-121
20661831-5	2010	Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak).	Curcumin	15-23	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	266-271
20661831-7	2010	Caspase-8 inhibition abrogated Bid cleavage and strongly reduced caspase-9 activation, suggesting that the cross-talk mechanism mediated by caspase-8-dependent Bid cleavage can contribute to the activation of the intrinsic apoptotic pathway by curcumin + carnosic acid.	Curcumin	244-252	caspase 9	Homo sapiens	65-74
19955845-0	2010	Curcumin attenuates glucose-induced monocyte chemoattractant protein-1 synthesis in aortic endothelial cells by modulating the nuclear factor-kappaB pathway.	Curcumin	0-8	C-C motif chemokine ligand 2	Rattus norvegicus	36-70
19955845-7	2010	Curcumin (30 micromol/l) significantly decreased HG-induced MCP-1 protein (74%) and mRNA (53%) synthesis.	Curcumin	0-8	C-C motif chemokine ligand 2	Rattus norvegicus	60-65
19955845-10	2010	CONCLUSION: Curcumin blocks HG-induced MCP-1 synthesis in RAECs partly via the NFkappaB pathway.	Curcumin	12-20	C-C motif chemokine ligand 2	Rattus norvegicus	39-44
19893028-8	2009	In the curcumin- and myricetin-treated groups, changes in the Abeta profile were similar to those in the RA-treated group, but Abeta plaque deposition was not significantly decreased.	Curcumin	7-15	amyloid beta (A4) precursor protein	Mus musculus	62-67
20043851-4	2009	Curcumin was previously identified as a weak inhibitor of FANCD2-Ub.	Curcumin	0-8	FA complementation group D2	Homo sapiens	58-64
20043851-6	2009	RESULTS: Using a replication-free assay in Xenopus extracts, we screened monoketone analogs of curcumin for inhibition of FANCD2-Ub and identified analog EF24 as a strong inhibitor.	Curcumin	95-103	FA complementation group D2 L homeolog	Xenopus laevis	122-128
19715544-8	2009	However, only HSS-888, curcumin and demethoxycurcumin significantly decreased A beta secretion (approximately 20%) in SweAPP N2A cells.	Curcumin	23-31	amyloid beta (A4) precursor protein	Mus musculus	78-84
19726538-6	2009	FACS analysis with Annexin V-FITC/7-aminoactinomycin D staining demonstrated curcumin-induced early apoptosis after 3, 6, 12 and 24 h treatment and nearly no necrosis.	Curcumin	77-85	annexin A5	Mus musculus	19-28
19715674-2	2009	Recent reports have shown curcumin to have antioxidant, anti-inflammatory and anti-tumor properties as well as affecting the 5"-AMP activated protein kinase (AMPK), mTOR and STAT-3 signaling pathways.	Curcumin	26-34	mechanistic target of rapamycin kinase	Rattus norvegicus	165-169
19839007-7	2009	These curcumin-treated DC induced differentiation of naive CD4(+) T cells into Treg resembling Treg in the intestine, including both CD4(+)CD25(+) Foxp3(+) Treg and IL-10-producing Tr1 cells.	Curcumin	6-14	forkhead box P3	Mus musculus	147-152
19845678-8	2009	KEY RESULTS: Haem oxygenase-1 protein expression was strongly induced in pulmonary artery after 24-h incubation with either haemin (5 microM) or curcumin (2 microM), accompanied by a significant increase in HO activity.	Curcumin	145-153	heme oxygenase 1	Rattus norvegicus	13-29
19845678-10	2009	Induction of HO-1 by curcumin or haemin protected against TNFalpha-induced hyporesponsiveness to ACh.	Curcumin	21-29	heme oxygenase 1	Rattus norvegicus	13-17
19393114-8	2009	Furthermore, curcumin inhibited proteasome complex activity and variably reduced expression of muscle-specific ubiquitin ligases: atrogin-1/muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MURF-1).	Curcumin	13-21	F-box protein 32	Mus musculus	130-160
20183254-8	2009	Curcumin also increased the protein levels of beclin 1 and membrane form LC3 (LC3-II).	Curcumin	0-8	beclin 1	Homo sapiens	46-54
20183254-8	2009	Curcumin also increased the protein levels of beclin 1 and membrane form LC3 (LC3-II).	Curcumin	0-8	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	73-76
20183254-8	2009	Curcumin also increased the protein levels of beclin 1 and membrane form LC3 (LC3-II).	Curcumin	0-8	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	78-84
19573523-6	2009	Curcumin was found to effectively inhibit the expression of several Wnt/beta-catenin pathway components-disheveled, beta-catenin, cyclin D1 and slug in both MCF-7 and MDA-MB-231.	Curcumin	0-8	snail family transcriptional repressor 2	Homo sapiens	144-148
19393114-8	2009	Furthermore, curcumin inhibited proteasome complex activity and variably reduced expression of muscle-specific ubiquitin ligases: atrogin-1/muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MURF-1).	Curcumin	13-21	F-box protein 32	Mus musculus	162-167
19573523-8	2009	Further, the protein levels of the positively regulated beta-catenin targets-cyclin D1 and slug, were downregulated by curcumin treatment.	Curcumin	119-127	snail family transcriptional repressor 2	Homo sapiens	91-95
19288529-3	2009	The results were as follows: (1) genistein and curcumin inhibited the production of MUC5AC mucin protein induced by EGF, dose-dependently; (2) genistein and curcumin also inhibited the expression of MUC5AC mucin gene induced by EGF.	Curcumin	47-55	epidermal growth factor	Homo sapiens	228-231
19702951-7	2009	The effect of the Wnt canonical pathway on OPG production was evaluated using small interfering (si) RNA for beta-catenin and the effect of AP-1 on OPG production was evaluated using the AP-1 inhibitor curcumin.	Curcumin	202-210	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	187-191
19702951-10	2009	The siRNA for beta-catenin suppressed the IL-1alpha-induced OPG production in both PDL cells and hGFs, whereas the AP-1 inhibitor curcumin augmented the IL-1alpha-induced OPG production in PDL cells, but not in hGFs.	Curcumin	130-138	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	115-119
19288529-3	2009	The results were as follows: (1) genistein and curcumin inhibited the production of MUC5AC mucin protein induced by EGF, dose-dependently; (2) genistein and curcumin also inhibited the expression of MUC5AC mucin gene induced by EGF.	Curcumin	157-165	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	84-90
19288529-3	2009	The results were as follows: (1) genistein and curcumin inhibited the production of MUC5AC mucin protein induced by EGF, dose-dependently; (2) genistein and curcumin also inhibited the expression of MUC5AC mucin gene induced by EGF.	Curcumin	157-165	epidermal growth factor	Homo sapiens	116-119
19288529-3	2009	The results were as follows: (1) genistein and curcumin inhibited the production of MUC5AC mucin protein induced by EGF, dose-dependently; (2) genistein and curcumin also inhibited the expression of MUC5AC mucin gene induced by EGF.	Curcumin	157-165	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	199-205
19809577-0	2009	Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin.	Curcumin	132-140	BRCA1 DNA repair associated	Homo sapiens	18-23
19288529-3	2009	The results were as follows: (1) genistein and curcumin inhibited the production of MUC5AC mucin protein induced by EGF, dose-dependently; (2) genistein and curcumin also inhibited the expression of MUC5AC mucin gene induced by EGF.	Curcumin	157-165	epidermal growth factor	Homo sapiens	228-231
19809577-4	2009	We demonstrate here that the bioactive food compound curcumin induces DNA damage in triple negative breast cancer cells in association with phosphorylation, increased expression, and cytoplasmic retention of the BRCA1 protein.	Curcumin	53-61	BRCA1 DNA repair associated	Homo sapiens	212-217
19288529-4	2009	This result suggests that genistein and curcumin can regulate mucin gene expression and production of mucin protein induced by EGF, by directly acting on airway epithelial cells.	Curcumin	40-48	epidermal growth factor	Homo sapiens	127-130
20055131-0	2009	[Effect of p21-targeted shRNA on curcumin-induced apoptosis of human hepatoma Huh7 cells].	Curcumin	33-41	H3 histone pseudogene 16	Homo sapiens	11-14
20055131-1	2009	In the present study, shRNA plasmid of pSi-p21 targeting p21 mRNA was constructed and the effect of p21 shRNA on curcumin-induced apoptosis of human hepatoma Huh7 cells was investigated.	Curcumin	113-121	H3 histone pseudogene 16	Homo sapiens	57-60
20055131-1	2009	In the present study, shRNA plasmid of pSi-p21 targeting p21 mRNA was constructed and the effect of p21 shRNA on curcumin-induced apoptosis of human hepatoma Huh7 cells was investigated.	Curcumin	113-121	H3 histone pseudogene 16	Homo sapiens	57-60
19674910-1	2009	Recent reports show that the natural beta-diketone curcumin displays important biological properties regarding the intercellular adhesion molecule-1 (ICAM-1), which plays a critical role in the immune responses and inflammation.	Curcumin	51-59	intercellular adhesion molecule 1	Homo sapiens	115-148
20055131-2	2009	The effect of curcumin on the expression of p21 mRNA and protein and the silence efficiency of pSi-p21 were detected with RT-PCR and Western blotting.	Curcumin	14-22	H3 histone pseudogene 16	Homo sapiens	44-47
19674910-1	2009	Recent reports show that the natural beta-diketone curcumin displays important biological properties regarding the intercellular adhesion molecule-1 (ICAM-1), which plays a critical role in the immune responses and inflammation.	Curcumin	51-59	intercellular adhesion molecule 1	Homo sapiens	150-156
20055131-3	2009	The effect of pSi-p21 on curcumin-induced apoptosis of Huh7 cells was evaluated with DAPI staining.	Curcumin	25-33	H3 histone pseudogene 16	Homo sapiens	18-21
19674910-2	2009	In this study the ICAM-1 inhibitory activity of beta-diketone compounds, which are curcumin models lacking aromatic peripheral hydroxyl and methoxy groups, along with some metal derivatives is investigated.	Curcumin	83-91	intercellular adhesion molecule 1	Homo sapiens	18-24
20055131-4	2009	The results showed that curcumin significantly upregulated p21 mRNA and protein expression, which was knocked down by pSi-p21 of Huh7 cells.	Curcumin	24-32	H3 histone pseudogene 16	Homo sapiens	59-62
19763044-0	2009	Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway.	Curcumin	23-31	protein kinase C, delta	Mus musculus	160-168
20055131-4	2009	The results showed that curcumin significantly upregulated p21 mRNA and protein expression, which was knocked down by pSi-p21 of Huh7 cells.	Curcumin	24-32	H3 histone pseudogene 16	Homo sapiens	122-125
19763044-0	2009	Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway.	Curcumin	23-31	mitogen-activated protein kinase 8	Mus musculus	169-172
19763044-7	2009	As for the mechanism, curcumin inhibited activating phosphorylation of protein kinase Cdelta (PKCdelta) in CIA, FLS, and chondrocytes.	Curcumin	22-30	protein kinase C, delta	Mus musculus	71-92
20055131-5	2009	DAPI staining results showed that pSi-p21 significantly decreased curcumin-induced apoptosis of Huh7 cells.	Curcumin	66-74	H3 histone pseudogene 16	Homo sapiens	38-41
19763044-7	2009	As for the mechanism, curcumin inhibited activating phosphorylation of protein kinase Cdelta (PKCdelta) in CIA, FLS, and chondrocytes.	Curcumin	22-30	protein kinase C, delta	Mus musculus	94-102
19763044-8	2009	Curcumin also suppressed the JNK and c-Jun activation in those cells.	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	29-32
20055131-6	2009	The data suggested that curcumin induced apoptosis of Huh7 cells via upregulation of p21 expression.	Curcumin	24-32	H3 histone pseudogene 16	Homo sapiens	85-88
19763044-9	2009	This study suggests that the suppression of MMP-1 and MMP-3 production by curcumin in CIA is mediated through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway.	Curcumin	74-82	protein kinase C, delta	Mus musculus	128-136
19681867-3	2009	These paradoxical findings are extended in this issue: Kang and Chen demonstrate that while low-density lipoproteins (LDL) can activate HSCs, curcumin can inhibit this process by activation of PPARgamma, which not only represses gene expression of SREBP-2 and LDLR, but via induction of expression of SREBP-1c, restores the lipid storage capacity characteristic of quiescent HSCs, suggesting that curcumin may be of therapeutic usage in protecting against liver steatosis and fibrosis.	Curcumin	142-150	low density lipoprotein receptor	Homo sapiens	260-264
19763044-9	2009	This study suggests that the suppression of MMP-1 and MMP-3 production by curcumin in CIA is mediated through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway.	Curcumin	74-82	mitogen-activated protein kinase 8	Mus musculus	145-148
19501152-7	2009	In PCC4 cells, piplartine inhibited the cell cycle progression by inactivating cdk2 and destabilizing cyclin D1, whereas diferuloylmethane combination inhibited the ERK1/2 and Raf-1 signaling in addition to the inhibition of cell cycle progression.	Curcumin	121-138	v-raf-leukemia viral oncogene 1	Mus musculus	176-181
19681867-3	2009	These paradoxical findings are extended in this issue: Kang and Chen demonstrate that while low-density lipoproteins (LDL) can activate HSCs, curcumin can inhibit this process by activation of PPARgamma, which not only represses gene expression of SREBP-2 and LDLR, but via induction of expression of SREBP-1c, restores the lipid storage capacity characteristic of quiescent HSCs, suggesting that curcumin may be of therapeutic usage in protecting against liver steatosis and fibrosis.	Curcumin	142-150	sterol regulatory element binding transcription factor 1	Homo sapiens	301-309
19693275-0	2009	Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis.	Curcumin	85-93	apoptosis inducing factor mitochondria associated 1	Homo sapiens	56-59
19513510-0	2009	Curcumin induces apoptosis through FAS and FADD, in caspase-3-dependent and -independent pathways in the N18 mouse-rat hybrid retina ganglion cells.	Curcumin	0-8	Fas (TNFRSF6)-associated via death domain	Mus musculus	43-47
19693275-7	2009	Indeed, curcumin caused nuclear translocation of AIF, which could be blocked by the antioxidant N-acetyl cysteine.	Curcumin	8-16	apoptosis inducing factor mitochondria associated 1	Homo sapiens	49-52
19693275-15	2009	CONCLUSIONS: Curcumin-induced fibroblast apoptosis is totally caspase-independent and relies on the mitochondrial formation of ROS and the subsequent nuclear translocation of AIF, which is released from a mitochondrial pore that involves VDAC, Bax and possibly ceramides.	Curcumin	13-21	apoptosis inducing factor mitochondria associated 1	Homo sapiens	175-178
19020987-0	2009	Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, Na+, K+ ATPase and protein kinase C in adult and old rat brain regions.	Curcumin	0-8	protein kinase C, gamma	Rattus norvegicus	110-126
19513510-9	2009	Curcumin also promoted the levels of Fas and FADD, Bax, cytochrome c release, but decreased the levels of Bcl-2 causing changes of DeltaPsim.	Curcumin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	51-54
19020987-4	2009	In animals co-administered with curcumin and aluminium, the levels of lipid peroxidation, activities of PKC and AChE were significantly lowered while the activities of SOD, GPx, GST and Na(+), K(+)-ATPase were significantly enhanced in the two brain regions studied indicating curcumin"s protective effects against aluminium toxicity.	Curcumin	32-40	protein kinase C, gamma	Rattus norvegicus	104-107
19020987-5	2009	Though the magnitudes of curcumin-induced alterations varied in young and old animals, the results of the present study also demonstrated that curcumin exerts a protective effect against aluminium-induced elevation of ageing-related changes by modulating the extent of oxidative stress (by upregulating the activities of antioxidant enzymes) and by regulating the activities of Na(+), K(+) ATPase, PKC and AChE.	Curcumin	143-151	protein kinase C, gamma	Rattus norvegicus	398-401
19513510-10	2009	Curcumin also induced endoplasmic reticulum stress in N18 cells which was based on the changes of GADD153 and GRP78 and caused Ca2+ release.	Curcumin	0-8	DNA-damage inducible transcript 3	Rattus norvegicus	98-105
19401701-0	2009	Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells.	Curcumin	26-34	ATM serine/threonine kinase	Homo sapiens	14-17
19191010-4	2009	Curcumin causes distinct inhibition of human telomerase reverse transcriptase (hTERT) the catalytic core of telomerase thereby reducing proliferation of cancer cells.	Curcumin	0-8	telomerase reverse transcriptase	Homo sapiens	79-84
19594758-9	2009	Curcumin-dependent activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) differentially regulated the expression of the transcription factors, sterol regulatory element-binding proteins (SREBPs), in activated HSCs, resulting in the suppression of LDLR gene expression.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	33-81
19191010-7	2009	Curcumin acts as an anti-inflammatory and anti-proliferative agent by causing down regulation of COX-2, iNOS and cyclin D1 in all the three cell lines but to different extent.	Curcumin	0-8	inositol-3-phosphate synthase 1	Homo sapiens	104-108
19594758-9	2009	Curcumin-dependent activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) differentially regulated the expression of the transcription factors, sterol regulatory element-binding proteins (SREBPs), in activated HSCs, resulting in the suppression of LDLR gene expression.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	83-92
19288022-9	2009	Our results show that one molecular mechanism of curcumin inhibits the proliferation of MDA-MB-231 cells either through up-regulating p21 expression and then inducing apoptosis, or through up-regulating the Bax to Bcl-2 ratio and then inducing apoptosis.	Curcumin	49-57	H3 histone pseudogene 16	Homo sapiens	134-137
19594758-10	2009	CONCLUSIONS AND IMPLICATIONS: Curcumin suppressed LDLR gene expression in activated HSCs in vitro by activating PPARgamma and differentially regulating gene expression of SREBPs, reducing cellular cholesterol and attenuating the stimulatory effects of LDL on HSC activation.	Curcumin	30-38	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	112-121
19326074-6	2009	Biochemical analysis showed that the expression of Bax, Bid and cytochrome C were up-regulated, while the expression of oncogene c-Myc was down regulated after curcumin treatment.	Curcumin	160-168	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	129-134
20141610-6	2009	Pre-treatment with the activator protein-1 (AP-1) inhibitor curcumin attenuated TNF-alpha induced transcription of the TGF-beta(1) gene.	Curcumin	60-68	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	23-42
19183254-5	2009	In neurons, curcumin and to a lesser extent tBHQ increased GCL activity and GSH levels, while quercetin decreased GSH and led to cell death.	Curcumin	12-20	glutamate-cysteine ligase, modifier subunit	Mus musculus	59-62
20141610-6	2009	Pre-treatment with the activator protein-1 (AP-1) inhibitor curcumin attenuated TNF-alpha induced transcription of the TGF-beta(1) gene.	Curcumin	60-68	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	44-48
19263217-5	2009	The real time PCR analysis showed that 20 microM of curcumin for 48 h treatment decreased ATM, ATR, BRCA1, 14-3-3sigma, DNA-PK and MGMT mRNA, and ATM and MGMT mRNA expression were inhibited in a time-dependent manner.	Curcumin	52-60	ATM serine/threonine kinase	Rattus norvegicus	90-93
19263217-5	2009	The real time PCR analysis showed that 20 microM of curcumin for 48 h treatment decreased ATM, ATR, BRCA1, 14-3-3sigma, DNA-PK and MGMT mRNA, and ATM and MGMT mRNA expression were inhibited in a time-dependent manner.	Curcumin	52-60	ATM serine/threonine kinase	Rattus norvegicus	146-149
19183254-9	2009	Our results indicate that GCLM is essential for the up-regulation of GCL activity induced by curcumin, quercetin and tBHQ.	Curcumin	93-101	glutamate-cysteine ligase, modifier subunit	Mus musculus	26-30
21155252-11	2009	CONCLUSION: Curcumin could attenuate the activation of p-ERK, p-CREB, c-fos in dorsal root ganglion to ameliorate the CCI-induced neuropathic pain.	Curcumin	12-20	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	70-75
19183254-9	2009	Our results indicate that GCLM is essential for the up-regulation of GCL activity induced by curcumin, quercetin and tBHQ.	Curcumin	93-101	glutamate-cysteine ligase, modifier subunit	Mus musculus	26-29
19605645-0	2009	Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.	Curcumin	178-186	mitogen-activated protein kinase 8	Mus musculus	104-127
19027755-1	2009	The study set out to determine (a) whether DNA damage is elevated in mice that carry mutations in the amyloid precursor protein (APP695swe) and presenilin 1 (PSEN1-dE9) that predispose to Alzheimer"s disease (AD) relative to non-transgenic control mice, and (b) whether increasing the intake of dietary polyphenols from curcumin or grape seed extract could reduce genomic instability events in a transgenic mouse model for AD.	Curcumin	320-328	presenilin 1	Mus musculus	158-163
19395473-0	2009	Polyethylene glycosylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1.	Curcumin	26-34	COP9 signalosome subunit 5	Homo sapiens	108-112
19395473-2	2009	Curcumin, an inhibitor of Jab1/CSN-associated kinase(s), has been reported to suppress tumor growth; however, curcumin is highly hydrophobic, and this feature prevents its usage as an antitumor drug.	Curcumin	0-8	COP9 signalosome subunit 5	Homo sapiens	26-30
19395473-2	2009	Curcumin, an inhibitor of Jab1/CSN-associated kinase(s), has been reported to suppress tumor growth; however, curcumin is highly hydrophobic, and this feature prevents its usage as an antitumor drug.	Curcumin	110-118	COP9 signalosome subunit 5	Homo sapiens	26-30
19176385-3	2009	Recently, we have shown that curcumin inhibits phosphorylation of p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), two downstream effector molecules of the mammalian target of rapamycin complex 1 (mTORC1) in numerous cancer cell lines.	Curcumin	29-37	ribosomal protein S6 kinase B1	Homo sapiens	83-87
19395473-7	2009	PEGylated curcumin increased protein stability of these proteins in pancreatic cancer cells and directly inhibited the activity of Jab1/CSN-associated kinases.	Curcumin	10-18	COP9 signalosome subunit 5	Homo sapiens	131-135
19395473-8	2009	Moreover, the inhibitory effect of PEGylated curcumin on cell proliferation was blunted in pancreatic cancer cells with Jab1 knockdown.	Curcumin	45-53	COP9 signalosome subunit 5	Homo sapiens	120-124
19176385-3	2009	Recently, we have shown that curcumin inhibits phosphorylation of p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), two downstream effector molecules of the mammalian target of rapamycin complex 1 (mTORC1) in numerous cancer cell lines.	Curcumin	29-37	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	126-150
19176385-3	2009	Recently, we have shown that curcumin inhibits phosphorylation of p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), two downstream effector molecules of the mammalian target of rapamycin complex 1 (mTORC1) in numerous cancer cell lines.	Curcumin	29-37	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	152-158
19176385-7	2009	This is evidenced by the findings that curcumin was able to inhibit phosphorylation of S6K1 and 4E-BP1 in the cells pretreated with PP2A inhibitor (okadaic acid) or AMPK inhibitor (compound C), or in the cells expressing dominant-negative (dn) PP2A, shRNA to PP2A-A subunit, or dn-AMPKalpha.	Curcumin	39-47	ribosomal protein S6 kinase B1	Homo sapiens	87-102
19176385-7	2009	This is evidenced by the findings that curcumin was able to inhibit phosphorylation of S6K1 and 4E-BP1 in the cells pretreated with PP2A inhibitor (okadaic acid) or AMPK inhibitor (compound C), or in the cells expressing dominant-negative (dn) PP2A, shRNA to PP2A-A subunit, or dn-AMPKalpha.	Curcumin	39-47	protein phosphatase 2 phosphatase activator	Homo sapiens	132-136
19176385-7	2009	This is evidenced by the findings that curcumin was able to inhibit phosphorylation of S6K1 and 4E-BP1 in the cells pretreated with PP2A inhibitor (okadaic acid) or AMPK inhibitor (compound C), or in the cells expressing dominant-negative (dn) PP2A, shRNA to PP2A-A subunit, or dn-AMPKalpha.	Curcumin	39-47	protein phosphatase 2 phosphatase activator	Homo sapiens	244-248
19176385-7	2009	This is evidenced by the findings that curcumin was able to inhibit phosphorylation of S6K1 and 4E-BP1 in the cells pretreated with PP2A inhibitor (okadaic acid) or AMPK inhibitor (compound C), or in the cells expressing dominant-negative (dn) PP2A, shRNA to PP2A-A subunit, or dn-AMPKalpha.	Curcumin	39-47	protein phosphatase 2 phosphatase activator	Homo sapiens	244-248
18841445-3	2009	In addition, the inhibitory effect of curcumin on ABCG2 was evaluated in brain capillaries from rats.	Curcumin	38-46	ATP binding cassette subfamily G member 2	Rattus norvegicus	50-55
18930076-4	2009	Curcuminoids inhibited AChE in the in-vitro assay with IC(50) value of 19.67, bisdemethoxycurcumin 16.84, demethoxycurcumin 33.14 and curcumin 67.69 microM.	Curcumin	90-98	acetylcholinesterase	Rattus norvegicus	23-27
18930076-5	2009	In the ex-vivo AChE assay, curcuminoids and its individual components except curcumin showed dose-dependent (3-10 mg/kg) inhibition in frontal cortex and hippocampus.	Curcumin	27-35	acetylcholinesterase	Rattus norvegicus	15-19
18930076-7	2009	These data indicate that curcuminoids and all individual components except curcumin possess pronounced AChE inhibitory activity.	Curcumin	25-33	acetylcholinesterase	Rattus norvegicus	103-107
19093868-0	2009	Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells.	Curcumin	0-8	peroxisome proliferator activated receptor alpha	Homo sapiens	61-65
19093868-4	2009	Stimulation of AMPK by curcumin resulted in the down-regulation of PPAR (peroxisome proliferator-activated receptor)-gamma in 3T3-L1 adipocytes and the decrease in COX-2 in MCF-7 cells.	Curcumin	23-31	peroxisome proliferator activated receptor alpha	Homo sapiens	67-71
19018768-0	2008	Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT.	Curcumin	0-8	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	134-138
19018768-5	2008	Curcumin inhibited CYP1A1 and 1B1 induction by TCDD at the mRNA and protein levels.	Curcumin	0-8	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	19-33
19018768-6	2008	Notably, the nuclear levels of arylhydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) were decreased by curcumin, but those in the cytoplasm were not.	Curcumin	116-124	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	66-90
19018768-6	2008	Notably, the nuclear levels of arylhydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) were decreased by curcumin, but those in the cytoplasm were not.	Curcumin	116-124	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	92-96
19018768-7	2008	It was also found that oxidative stress mediated the curcumin-induced degradations of AhR and ARNT.	Curcumin	53-61	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	94-98
19018768-9	2008	In conclusion, curcumin attenuates AhR/ARNT-mediated CYP induction by dioxin and presumably this mode-of-action may be responsible for the curcumin prevention of malignant transformation.	Curcumin	15-23	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	39-43
19018768-9	2008	In conclusion, curcumin attenuates AhR/ARNT-mediated CYP induction by dioxin and presumably this mode-of-action may be responsible for the curcumin prevention of malignant transformation.	Curcumin	139-147	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	39-43
18809455-9	2008	Moreover, curcumin induced Sa-reduced liver transaminases and phosphatases, plasma and brain AChE, and the levels of TP and Alb.	Curcumin	10-18	acetylcholinesterase	Rattus norvegicus	93-97
18664365-9	2008	Both the febrile response and overproduction of both glutamate and hydroxyl radicals in the hypothalamus caused by central administration of TNF-alpha, IL-1beta, or IL-6 could be suppressed by Curcumin.	Curcumin	193-201	tumor necrosis factor	Oryctolagus cuniculus	141-150
18664365-10	2008	These results indicate that systemic injection of Curcumin may exert its antipyresis by inhibiting the glutamate-hydroxyl radicals-PGE(2) pathways in the hypothalamus and circulating TNF-alpha, IL-1beta, and IL-6 accumulation during LPS fever.	Curcumin	50-58	tumor necrosis factor	Oryctolagus cuniculus	183-192
18678491-0	2008	Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors.	Curcumin	28-36	peroxiredoxin 5	Homo sapiens	60-81
18678491-1	2008	Series of curcumin derivatives were synthesized; the inhibitory activities on thioredoxin reductase (TrxR) of all analogues were evaluated by DTNB assay in vitro.	Curcumin	10-18	peroxiredoxin 5	Homo sapiens	78-99
18678491-1	2008	Series of curcumin derivatives were synthesized; the inhibitory activities on thioredoxin reductase (TrxR) of all analogues were evaluated by DTNB assay in vitro.	Curcumin	10-18	peroxiredoxin 5	Homo sapiens	101-105
18678491-2	2008	It is found that most of the analogues can inhibit TrxR in the low micromolar range; Structure-activity relationship analysis reveals that analogues with furan moiety have excellent inhibitory effect on TrxR in an irreversible manner, indicating that the furan moiety may serve as a possible pharmacophore during the interaction of curcumin analogues with TrxR.	Curcumin	332-340	peroxiredoxin 5	Homo sapiens	51-55
18678491-2	2008	It is found that most of the analogues can inhibit TrxR in the low micromolar range; Structure-activity relationship analysis reveals that analogues with furan moiety have excellent inhibitory effect on TrxR in an irreversible manner, indicating that the furan moiety may serve as a possible pharmacophore during the interaction of curcumin analogues with TrxR.	Curcumin	332-340	peroxiredoxin 5	Homo sapiens	203-207
18678491-2	2008	It is found that most of the analogues can inhibit TrxR in the low micromolar range; Structure-activity relationship analysis reveals that analogues with furan moiety have excellent inhibitory effect on TrxR in an irreversible manner, indicating that the furan moiety may serve as a possible pharmacophore during the interaction of curcumin analogues with TrxR.	Curcumin	332-340	peroxiredoxin 5	Homo sapiens	203-207
18641050-8	2008	Interestingly, pretreatment of animals with curcumin (NFkB blocker) attenuated hypoxia-induced vascular leakage in lungs with concomitant reduction of NFkB levels.	Curcumin	44-52	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	54-58
18641050-8	2008	Interestingly, pretreatment of animals with curcumin (NFkB blocker) attenuated hypoxia-induced vascular leakage in lungs with concomitant reduction of NFkB levels.	Curcumin	44-52	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	151-155
21479462-0	2008	Curcumin suppresses breast tumor angiogenesis by abrogating osteopontin-induced VEGF expression.	Curcumin	0-8	secreted phosphoprotein 1	Homo sapiens	60-71
18556656-3	2008	Time- and concentration-dependent inhibition of immunodetectable [(33)P]orthophosphate in UGTs and protein kinase Cepsilon (PKCepsilon), following treatment of LS180 cells with curcumin or the PKC inhibitor calphostin-C, suggested UGT phosphorylation is supported by active PKC(s).	Curcumin	177-185	protein kinase C epsilon	Homo sapiens	99-122
18556656-3	2008	Time- and concentration-dependent inhibition of immunodetectable [(33)P]orthophosphate in UGTs and protein kinase Cepsilon (PKCepsilon), following treatment of LS180 cells with curcumin or the PKC inhibitor calphostin-C, suggested UGT phosphorylation is supported by active PKC(s).	Curcumin	177-185	protein kinase C epsilon	Homo sapiens	124-134
18685195-2	2008	Most of them were more potent TrxR inhibitors than natural curcumin.	Curcumin	59-67	peroxiredoxin 5	Homo sapiens	30-34
18685195-3	2008	The structure-activity relationship was summarized, and the curcumin analog was found to inhibit TrxR irreversibly in a time-dependent manner.	Curcumin	60-68	peroxiredoxin 5	Homo sapiens	97-101
18348204-0	2008	Curcumin downregulates H19 gene transcription in tumor cells.	Curcumin	0-8	H19 imprinted maternally expressed transcript	Homo sapiens	23-26
18348204-2	2008	It has been shown that low doses of curcumin downregulate DNA topoisomerase II alpha (TOP2A) which is upregulated in many malignances.	Curcumin	36-44	DNA topoisomerase II alpha	Homo sapiens	86-91
18348204-6	2008	As expression of imprinted genes is often altered in tumors, we investigated the potential effect of curcumin treatment on transcription of the imprinted H19 gene, located distally from the CTCF binding site, in human tumor cell lines HCT 116, SW 620, HeLa, Cal 27, Hep-2 and Detroit 562.	Curcumin	101-109	H19 imprinted maternally expressed transcript	Homo sapiens	154-157
18348204-8	2008	Monoallelic IGF2 expression was maintained in curcumin-treated cancer cells, indicating the involvement of mechanism/s other than disturbance of CTCF insulator function at the IGF2/H19 locus.	Curcumin	46-54	insulin like growth factor 2	Homo sapiens	12-16
19051581-0	2008	Curcumin ameliorates aflatoxin-induced changes in SDH and ATPase activities in liver and kidney of mice.	Curcumin	0-8	aminoadipate-semialdehyde synthase	Mus musculus	50-53
19395473-9	2009	The results suggest that PEGylated curcumin inhibits cell proliferation through suppression of Jab1/CSN activity.	Curcumin	35-43	COP9 signalosome subunit 5	Homo sapiens	95-99
19051581-1	2008	The present investigation was an attempt to evaluate the ameliorative effect of curcumin on aflatoxin-induced changes in activities of succinate dehydrogenase (SDH) and adenosine triphosphatase (ATPase) in liver and kidney of mice.	Curcumin	80-88	aminoadipate-semialdehyde synthase	Mus musculus	135-158
19051581-1	2008	The present investigation was an attempt to evaluate the ameliorative effect of curcumin on aflatoxin-induced changes in activities of succinate dehydrogenase (SDH) and adenosine triphosphatase (ATPase) in liver and kidney of mice.	Curcumin	80-88	aminoadipate-semialdehyde synthase	Mus musculus	160-163
19726347-0	2009	[Effects of curcumin on the expression of nuclear factor-kappaB and intercellular adhesion molecular 1 in rats with cerebral ischemia-reperfusion injury].	Curcumin	12-20	intercellular adhesion molecule 1	Rattus norvegicus	68-102
19051581-7	2008	The results showed that in liver and kidney of mice activities of both the enzymes succinate dehydrogenase and adenosine triphosphatase were found to be reduced in the groups treated with low dose and high dose of aflatoxin, which were ameliorated by the treatment of curcumin along with aflatoxin in other groups.	Curcumin	268-276	aminoadipate-semialdehyde synthase	Mus musculus	83-106
19726347-1	2009	OBJECTIVE: To investigate the effects of curcumin on the expression of nuclear factor-kappaB (NF-kappaB) and intercellular adhesion molecular 1 (ICAM-1) in rats with cerebral ischemia-reperfusion (IR) injury.	Curcumin	41-49	intercellular adhesion molecule 1	Rattus norvegicus	109-143
19726347-1	2009	OBJECTIVE: To investigate the effects of curcumin on the expression of nuclear factor-kappaB (NF-kappaB) and intercellular adhesion molecular 1 (ICAM-1) in rats with cerebral ischemia-reperfusion (IR) injury.	Curcumin	41-49	intercellular adhesion molecule 1	Rattus norvegicus	145-151
19051581-8	2008	Thus, curcumin along with aflatoxin ameliorates aflatoxin-induced changes in succinate dehydrogenase and adenosine triphosphatase activities in liver and kidney of mice.	Curcumin	6-14	aminoadipate-semialdehyde synthase	Mus musculus	77-100
19726347-6	2009	At 6 h and 1, 3, and 7 days after the IR injury, the expression of NF-kappaB in curcumin treatment group showed significantly reduction in comparison with that in the IR model and solvent control groups (P&lt;0.05), and the content of ICAM-1 protein was also reduced, which was especially obvious at 1 and 3 days (P&lt;0.05).	Curcumin	80-88	intercellular adhesion molecule 1	Rattus norvegicus	235-241
19726347-7	2009	CONCLUSION: Curcumin can ameliorate cerebral pathological changes in the event of IR injury by suppressing the expressions of NF-kappaB and ICAM-1.	Curcumin	12-20	intercellular adhesion molecule 1	Rattus norvegicus	140-146
19594013-1	2009	OBJECTIVE: To observe the effect of different dosage of curcumin on expression of MMP-2 and MMP-9 in the tissue of cystiform in air-pouch mouse models after the injection of polyethylene wear particles, and to investigate its mechanism of intervening inflammatory response induced by wear particles.	Curcumin	56-64	matrix metallopeptidase 2	Mus musculus	82-87
18493855-7	2008	Our studies demonstrate that curcumin triggers ER stress and the activation of specific cell death pathways that feature caspase cleavage and activation, p23 cleavage, and downregulation of the anti-apoptotic Mcl-1 protein.	Curcumin	29-37	prostaglandin E synthase 3	Mus musculus	154-157
19594013-16	2009	Curcumin can restrain expression of MMP-2 and MMP-9 in cystiform tissue of air-pouch animal models, and expression of MMP-2 and MMP-9 may be regulated by the activation of NF-kappaB.	Curcumin	0-8	matrix metallopeptidase 2	Mus musculus	36-41
18357586-4	2008	Further, Curcumin inhibited LPS-induced IL-1 and IL-6 secretion and blockage of HO-1 expression/activity by HO-1 siRNA or HO-1 inhibitor, SnPP reversed the inhibitory effects of Curcumin on cytokines secretion.	Curcumin	178-186	heme oxygenase 1	Homo sapiens	80-84
19225048-12	2009	The decline in the anti-inflammatory peroxisome proliferator-activated receptor gamma (PPARgamma) seen in Nx animals was also counteracted by curcumin and enalapril.	Curcumin	142-150	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	37-85
19225048-12	2009	The decline in the anti-inflammatory peroxisome proliferator-activated receptor gamma (PPARgamma) seen in Nx animals was also counteracted by curcumin and enalapril.	Curcumin	142-150	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	87-96
19225048-14	2009	Curcumin dose dependently antagonized the TNF-alpha-mediated decrease in PPARgamma and blocked transactivation of NF-kappaB and repression of PPARgamma, indicating that the anti-inflamatory property of curcumin may be responsible for alleviating CRF in Nx animals.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	73-82
19225048-14	2009	Curcumin dose dependently antagonized the TNF-alpha-mediated decrease in PPARgamma and blocked transactivation of NF-kappaB and repression of PPARgamma, indicating that the anti-inflamatory property of curcumin may be responsible for alleviating CRF in Nx animals.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	142-151
19539560-7	2009	The proliferation of the MBP-reaction lymphocyte also was reduced in a curcumin dose-dependent manner.	Curcumin	71-79	myelin basic protein	Rattus norvegicus	25-28
19297423-5	2009	Supplementing the high-fat diet of mice with curcumin did not affect food intake but reduced body weight gain, adiposity, and microvessel density in adipose tissue, which coincided with reduced expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2.	Curcumin	45-53	vascular endothelial growth factor A	Mus musculus	208-242
18357586-4	2008	Further, Curcumin inhibited LPS-induced IL-1 and IL-6 secretion and blockage of HO-1 expression/activity by HO-1 siRNA or HO-1 inhibitor, SnPP reversed the inhibitory effects of Curcumin on cytokines secretion.	Curcumin	178-186	heme oxygenase 1	Homo sapiens	108-112
18357586-4	2008	Further, Curcumin inhibited LPS-induced IL-1 and IL-6 secretion and blockage of HO-1 expression/activity by HO-1 siRNA or HO-1 inhibitor, SnPP reversed the inhibitory effects of Curcumin on cytokines secretion.	Curcumin	178-186	heme oxygenase 1	Homo sapiens	108-112
18357586-5	2008	HO-1 over-expression produced the same inhibitory effects of Curcumin on IL-1 secretion.	Curcumin	61-69	heme oxygenase 1	Homo sapiens	0-4
19297423-5	2009	Supplementing the high-fat diet of mice with curcumin did not affect food intake but reduced body weight gain, adiposity, and microvessel density in adipose tissue, which coincided with reduced expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2.	Curcumin	45-53	vascular endothelial growth factor A	Mus musculus	244-248
19393026-9	2009	Inhibition of AP-1 with curcumin also inhibited 14-3-3gamma up-regulation indicating that ischemia-induced up-regulation of 14-3-3gamma in astrocyte involves activation of the JNK/p-c-Jun/AP-1 pathway.	Curcumin	24-32	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	182-187
19771848-0	2009	[Study on effects of curcumin on expressions of PDGF-BB, PDGFRbeta and ERK1 of HSC].	Curcumin	21-29	platelet derived growth factor receptor beta	Rattus norvegicus	57-66
19771848-1	2009	OBJECTIVE: To observe the effects of curcumin on expression of PDGF-BB, PDGFRbeta and ERK1 of rat Hepatic stellate cell (HSC-T6).	Curcumin	37-45	platelet derived growth factor receptor beta	Rattus norvegicus	72-81
19771848-4	2009	The protein levels of PDGF-BB, PDGFRbeta and ERK1 was detected by immunhistochemical examination; The influence of curcumin on expression of PDGF-BB, PDGFRbeta and ERK1 mRNA was detected by RT-PCR.	Curcumin	115-123	platelet derived growth factor receptor beta	Rattus norvegicus	150-159
19771848-6	2009	After the intervention of different concentration of curcumin,the masculine degrees of PDGF-BB, PDGFRbeta and ERK1 and the masculine cell population decreased obviously.	Curcumin	53-61	platelet derived growth factor receptor beta	Rattus norvegicus	96-105
19771848-8	2009	After the intervention of different concentration of curcumin, the expression of PDGF-BB, PDGFRbeta and ERK1 mRNA decreased in a dose-dependent manner.	Curcumin	53-61	platelet derived growth factor receptor beta	Rattus norvegicus	90-99
19771848-9	2009	CONCLUSION: Curcumin could inhibit the expression of PDGF-BB, PDGFRbeta and ERK1 which might be the mechanism of action curcumin on anti-fibrosis.	Curcumin	12-20	platelet derived growth factor receptor beta	Rattus norvegicus	62-71
19771848-9	2009	CONCLUSION: Curcumin could inhibit the expression of PDGF-BB, PDGFRbeta and ERK1 which might be the mechanism of action curcumin on anti-fibrosis.	Curcumin	120-128	platelet derived growth factor receptor beta	Rattus norvegicus	62-71
19302828-7	2009	Moreover, curcumin enhanced AC activity and cAMP levels in platelet and various brain regions, and up-regulated mRNA expressions of AC subtypes AC 2, AC 8 and cAMP response element binding protein (CREB) in the hippocampus, cortex and hypothalamus of the CUMS rats.	Curcumin	10-18	adenylate cyclase 2	Rattus norvegicus	144-148
19429032-0	2009	Curcumin attenuates ethanol-induced toxicity in HT22 hippocampal cells by activating mitogen-activated protein kinase phosphatase-1.	Curcumin	0-8	dual specificity phosphatase 1	Mus musculus	85-131
19429032-3	2009	In this report, we examined the potential involvement of MKP-1 in cytoprotective effects of the well-known antioxidant curcumin.	Curcumin	119-127	dual specificity phosphatase 1	Mus musculus	57-62
19429032-6	2009	Curcumin attenuated ethanol-induced cell death, inhibited activation of p38 MAPK, and activated MKP-1.	Curcumin	0-8	dual specificity phosphatase 1	Mus musculus	96-101
19429032-8	2009	Our results suggest that curcumin can attenuate ethanol-induced neurotoxicity by activating MKP-1 which acts as the negative regulator of p38 MAPK.	Curcumin	25-33	dual specificity phosphatase 1	Mus musculus	92-97
19161989-4	2009	Curcumin increased NCAM PSA expression in cultured neuro-2A neuroblastoma cells and this was inversely related to PKCdelta protein expression.	Curcumin	0-8	protein kinase C, delta	Mus musculus	114-122
18410527-2	2009	We show that 25-microM curcumin causes fibroblast apoptosis and that this could be inhibited by co-administration of antioxidants N-acetyl-l-cysteine (NAC), biliverdin or bilirubin, suggesting that reactive oxygen species (ROS) are involved.	Curcumin	23-31	X-linked Kx blood group	Homo sapiens	151-154
18410527-3	2009	This is supported by our observation that 25-microM curcumin caused the generation of ROS, which could be completely blocked by addition of NAC or bilirubin.	Curcumin	52-60	X-linked Kx blood group	Homo sapiens	140-143
19294764-0	2009	Curcumin suppresses PPARdelta expression and related genes in HT-29 cells.	Curcumin	0-8	peroxisome proliferator activated receptor delta	Homo sapiens	20-29
19294764-1	2009	AIM: To investigate the effects of curcumin on the expression of peroxisome proliferator-activated receptordelta (PPARdelta) and related genes in HT-29 cells.	Curcumin	35-43	peroxisome proliferator activated receptor delta	Homo sapiens	65-112
19294764-1	2009	AIM: To investigate the effects of curcumin on the expression of peroxisome proliferator-activated receptordelta (PPARdelta) and related genes in HT-29 cells.	Curcumin	35-43	peroxisome proliferator activated receptor delta	Homo sapiens	114-123
19294764-6	2009	The expression of PPARdelta, 14-3-3epsilon and VEGF was reduced and the activity of beta-catenin/Tcf-4 signaling was inhibited by curcumin treatment.	Curcumin	130-138	peroxisome proliferator activated receptor delta	Homo sapiens	18-27
19294764-7	2009	CONCLUSION: Curcumin can induce apoptosis of HT-29 cells and down-regulate the expression of PPARdelta, 14-3-3epsilon and VEGF in HT-29.	Curcumin	12-20	peroxisome proliferator activated receptor delta	Homo sapiens	93-102
19294764-7	2009	CONCLUSION: Curcumin can induce apoptosis of HT-29 cells and down-regulate the expression of PPARdelta, 14-3-3epsilon and VEGF in HT-29.	Curcumin	12-20	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	104-117
19228728-8	2009	Moreover, curcumin suppressed expression of the anti-apoptotic proteins Mcl-1 and X-linked inhibitor of apoptosis protein (XIAP), and up-regulated the pro-apoptotic protein BIM.	Curcumin	10-18	X-linked inhibitor of apoptosis	Homo sapiens	82-121
19228728-8	2009	Moreover, curcumin suppressed expression of the anti-apoptotic proteins Mcl-1 and X-linked inhibitor of apoptosis protein (XIAP), and up-regulated the pro-apoptotic protein BIM.	Curcumin	10-18	X-linked inhibitor of apoptosis	Homo sapiens	123-127
19075017-0	2009	Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase Cdelta-STAT1 signaling pathway in interferon-gamma-stimulated murine dendritic cells.	Curcumin	0-8	signal transducer and activator of transcription 1	Mus musculus	126-131
19075017-6	2009	We found that curcumin suppressed STAT1 activation by directly inhibiting Janus-activated kinase 1/2 and protein kinase Cdelta phosphorylation in bone marrow-derived DCs, suppressing the subsequent translocation and binding of STAT1 to the GAS element of the IRF-1 promoter.	Curcumin	14-22	signal transducer and activator of transcription 1	Mus musculus	34-39
19075017-6	2009	We found that curcumin suppressed STAT1 activation by directly inhibiting Janus-activated kinase 1/2 and protein kinase Cdelta phosphorylation in bone marrow-derived DCs, suppressing the subsequent translocation and binding of STAT1 to the GAS element of the IRF-1 promoter.	Curcumin	14-22	signal transducer and activator of transcription 1	Mus musculus	227-232
19114310-4	2009	These bisubstrate analogs exhibit stronger potency in the inhibition of Esa1 and Tip60 compared to the small molecules curcumin and anacardic acid.	Curcumin	119-127	lysine acetyltransferase 5	Homo sapiens	72-76
19114310-4	2009	These bisubstrate analogs exhibit stronger potency in the inhibition of Esa1 and Tip60 compared to the small molecules curcumin and anacardic acid.	Curcumin	119-127	lysine acetyltransferase 5	Homo sapiens	81-86
19118501-3	2009	The effective dose that produced 50% growth inhibition (GI50) was calculated from the log dose-response curve of fixed-combinations of xanthorrhizol and curcumin generated from the sulforhodamine B (SRB) assay.	Curcumin	153-161	chaperonin containing TCP1 subunit 4	Homo sapiens	199-202
19255645-8	2009	Curcumin shows good and optimal binding to both HAT and SERCA enzymes; therefore it might be a good inhibitor of these key enzymes in Plasmodium.	Curcumin	0-8	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	56-61
19255645-9	2009	Curcumin is reported to act synergistically with artemisinin which forms covalent adducts with the transmembrane proteins (SERCA enzyme) and inactivates them, thus inhibiting the activity of Plasmodium parasite.	Curcumin	0-8	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	123-128
18761777-8	2009	Microarray and pathway analyses suggested that the effect of dietary curcumin on colon inflammation could be via an up-regulation of xenobiotic metabolism and a down-regulation of pro-inflammatory pathways, probably mediated by pregnane X receptor (Pxr) and peroxisome proliferator-activated receptor alpha (Ppara) activation of retinoid X receptor (Rxr).	Curcumin	69-77	nuclear receptor subfamily 1, group I, member 2	Mus musculus	228-247
18761777-8	2009	Microarray and pathway analyses suggested that the effect of dietary curcumin on colon inflammation could be via an up-regulation of xenobiotic metabolism and a down-regulation of pro-inflammatory pathways, probably mediated by pregnane X receptor (Pxr) and peroxisome proliferator-activated receptor alpha (Ppara) activation of retinoid X receptor (Rxr).	Curcumin	69-77	nuclear receptor subfamily 1, group I, member 2	Mus musculus	249-252
19249123-10	2009	Specific IgG and IgG1 responses against both soluble worm antigen (SWAP) and soluble egg antigen (SEA) were augmented with curcumin treatment, but IgM and IgG2a responses were not significantly changed.	Curcumin	123-131	LOC105243590	Mus musculus	17-21
19484960-16	2009	CONCLUSIONS: Curcumin can induce apoptosis of pulmonary fibroblasts in rats with bleomycin-induced pulmonary fibrosis and the mechanism may be related to the activation of Caspase-3, Caspase-8, and Caspase-9.	Curcumin	13-21	caspase 8	Rattus norvegicus	183-192
19055861-11	2008	Curcumin decreased c-Abl levels in cells expressing the wild, but not the mutant, BCR-ABL oncogene.	Curcumin	0-8	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	19-24
19055861-13	2008	CONCLUSIONS: Curcumin is effective against leukemic cells expressing p210 BCR-ABL and T315I BCR-ABL and holds promise in treating BCR-ABL-induced B-ALL.	Curcumin	13-21	envoplakin	Mus musculus	69-73
18784349-3	2008	In addition, curcumin is a potent inducer of the cytoprotective enzyme heme oxygenase-1 (HO-1) in other cell types.	Curcumin	13-21	heme oxygenase 1	Rattus norvegicus	71-87
18784349-3	2008	In addition, curcumin is a potent inducer of the cytoprotective enzyme heme oxygenase-1 (HO-1) in other cell types.	Curcumin	13-21	heme oxygenase 1	Rattus norvegicus	89-93
18784349-4	2008	Therefore, the aims of this study were to 1) characterize the effect of curcumin on HO-1 gene expression in PSCs, 2) explore whether HO-1 induction contributes to the inhibitory effect of curcumin on PSC proliferation, and 3) clarify the involvement of the mitogen-activated protein kinase (MAPK) family in this context.	Curcumin	72-80	heme oxygenase 1	Rattus norvegicus	84-88
18784349-7	2008	Curcumin induced HO-1 gene expression in PSCs in a time- and dose-dependent manner and inhibited PDGF-mediated ERK1/2 phosphorylation and PSC proliferation.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	17-21
18784349-9	2008	Our data provide evidence that HO-1 induction contributes to the inhibitory effect of curcumin on PSC proliferation.	Curcumin	86-94	heme oxygenase 1	Rattus norvegicus	31-35
18719352-0	2008	Curcumin inhibits osteoclastogenesis by decreasing receptor activator of nuclear factor-kappaB ligand (RANKL) in bone marrow stromal cells.	Curcumin	0-8	TNF superfamily member 11	Homo sapiens	51-101
18719352-0	2008	Curcumin inhibits osteoclastogenesis by decreasing receptor activator of nuclear factor-kappaB ligand (RANKL) in bone marrow stromal cells.	Curcumin	0-8	TNF superfamily member 11	Homo sapiens	103-108
18719352-5	2008	Exposure to curcumin led to dose-dependent suppression of osteoclastogenesis in the coculture system, and to reduced expression of RANKL in IL-1alpha-stimulated BMSCs.	Curcumin	12-20	TNF superfamily member 11	Homo sapiens	131-136
18719352-6	2008	Addition of RANKL abolished the inhibition of osteoclastogenesis by curcumin, whereas the addition of prostaglandin E2(PGE2) did not.	Curcumin	68-76	TNF superfamily member 11	Homo sapiens	12-17
18594769-5	2008	Our results demonstrated that 5-FC/CD-UPRT-mediated apoptotic cell death was more than 5-FC/CD, which could be further potentiated with anticancer compound curcumin.	Curcumin	156-164	uracil phosphoribosyltransferase homolog	Homo sapiens	38-42
18299980-5	2008	The identification of several new cell cycle control genes, including the apoptosis-related protein (pirin) and insulin-like growth factor (IGF), and of the neurofilament M protein involved in neurogenesis suggests that curcumin may have applicability in the treatment of a spectrum of neurodegenerative diseases.	Curcumin	220-228	pirin	Rattus norvegicus	101-106
18234541-12	2008	The addition of NAC, curcumin, PD98059, and staurosporine markedly inhibited the arecoline-induced HSP70 expression (p&lt;0.05).	Curcumin	21-29	heat shock protein family A (Hsp70) member 4	Homo sapiens	99-104
18234541-15	2008	In addition, arecoline-induced HSP70 expression was downregulated by NAC, curcumin, PD98059, and staurosporine.	Curcumin	74-82	heat shock protein family A (Hsp70) member 4	Homo sapiens	31-36
18583042-0	2008	Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.	Curcumin	89-97	beta-secretase 1	Rattus norvegicus	56-61
18357586-6	2008	Collectively, our results suggest that Curcumin inhibits cytokines secretion within LPS-stimulated monocytes through a mechanism that involves the action of HO-1.	Curcumin	39-47	heme oxygenase 1	Homo sapiens	157-161
18718065-6	2008	The curcumin could enhance toxicity of CTX on HT/CTX cells through inhibition of FA/BRCA pathway which was realized by suppression of FANCD2 monoubiquitination.	Curcumin	4-12	FA complementation group D2	Homo sapiens	134-140
18332871-4	2008	We hypothesized that the enhancement of PPARgamma activity by curcumin might result in the interruption of PDGF and EGF signaling.	Curcumin	62-70	epidermal growth factor	Homo sapiens	116-119
18332871-5	2008	Our experiments demonstrated that curcumin, with different treatment strategies, showed different efficiencies in the inhibition of PDGF- or EGF-stimulated HSC proliferation.	Curcumin	34-42	epidermal growth factor	Homo sapiens	141-144
18332871-5	2008	Our experiments demonstrated that curcumin, with different treatment strategies, showed different efficiencies in the inhibition of PDGF- or EGF-stimulated HSC proliferation.	Curcumin	34-42	fucosyltransferase 1 (H blood group)	Homo sapiens	156-159
18332871-6	2008	Further experiments observed that curcumin dose dependently reduced gene expression of PDGF and EGF receptors (ie, PDGF-betaR and EGFR), which required PPARgamma activation.	Curcumin	34-42	epidermal growth factor	Homo sapiens	96-99
18332871-11	2008	Our results collectively demonstrated that enhancement of PPARgamma activity by curcumin interrupted PDGF and EGF signaling in activated HSCs by reducing the phosphorylation levels of PDGF-betaR and EGFR, and by suppressing the receptor gene expression.	Curcumin	80-88	epidermal growth factor	Homo sapiens	110-113
18178166-1	2008	Using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from Curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and NIH3T3 and two tumor cell lines: EL4 and MCF7.	Curcumin	89-97	epilepsy 4	Mus musculus	257-260
18332871-12	2008	These results provide novel insights into the mechanisms of curcumin in the inhibition of HSC activation and the suppression of hepatic fibrogenesis.	Curcumin	60-68	fucosyltransferase 1 (H blood group)	Homo sapiens	90-93
18316600-4	2008	Here, we report that transcription of the p21(Waf1/Cip1) gene is activated by early growth response-1 (Egr-1) independently of p53 in response to curcumin treatment in U-87MG human glioblastoma cells.	Curcumin	146-154	early growth response 1	Homo sapiens	78-101
17999991-0	2008	Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB.	Curcumin	0-8	C-X-C motif chemokine ligand 1	Homo sapiens	50-62
17999991-6	2008	Further validation of the microarray results by quantitative real-time reverse transcription-polymerase chain reaction, western blots and enzyme-linked immunosorbent assay revealed that Curcumin impairs transcription of CXCL1 and -2 &gt;24 h and reduces the corresponding proteins.	Curcumin	186-194	C-X-C motif chemokine ligand 1	Homo sapiens	220-232
17999991-9	2008	We therefore suggest that the decrease of CXCL1 and -2 mediated by Curcumin is involved in the inhibition of metastasis.	Curcumin	67-75	C-X-C motif chemokine ligand 1	Homo sapiens	42-54
18316600-4	2008	Here, we report that transcription of the p21(Waf1/Cip1) gene is activated by early growth response-1 (Egr-1) independently of p53 in response to curcumin treatment in U-87MG human glioblastoma cells.	Curcumin	146-154	early growth response 1	Homo sapiens	103-108
18381954-8	2008	Moreover, curcumin suppressed NF-kappaB activity and the expression of NF-kappaB-regulated gene products (cyclin D1, c-myc, Bcl-2, Bcl-xL, cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase-9, and vascular endothelial growth factor), many of which were induced by radiation therapy and mediate radioresistance.	Curcumin	10-18	cyclin D1	Mus musculus	106-115
18316600-6	2008	Egr-1 expression is induced by curcumin through extracellular signal-regulated kinase (ERK) and c-Jun NH(2)-terminal kinase (JNK), but not the p38, mitogen-activated protein kinase (MAPK) pathways, which mediate the transactivation of Elk-1.	Curcumin	31-39	early growth response 1	Homo sapiens	0-5
18316600-7	2008	Transient expression of Egr-1 enhanced curcumin-induced p21(Waf1/Cip1) promoter activity, whereas suppression of Egr-1 expression by small interfering RNA abrogated the ability of curcumin to induce p21(Waf1/Cip1) promoter activity.	Curcumin	39-47	early growth response 1	Homo sapiens	24-29
18292803-2	2008	We hypothesized that curcumin, a natural polyphenolic compound abundant in the spice turmeric and a known suppressor of histone acetylation, would suppress cardiac hypertrophy through the disruption of p300 histone acetyltransferase-dependent (p300-HAT-dependent) transcriptional activation.	Curcumin	21-29	E1A binding protein p300	Mus musculus	202-206
18292803-2	2008	We hypothesized that curcumin, a natural polyphenolic compound abundant in the spice turmeric and a known suppressor of histone acetylation, would suppress cardiac hypertrophy through the disruption of p300 histone acetyltransferase-dependent (p300-HAT-dependent) transcriptional activation.	Curcumin	21-29	E1A binding protein p300	Mus musculus	244-248
18316600-7	2008	Transient expression of Egr-1 enhanced curcumin-induced p21(Waf1/Cip1) promoter activity, whereas suppression of Egr-1 expression by small interfering RNA abrogated the ability of curcumin to induce p21(Waf1/Cip1) promoter activity.	Curcumin	180-188	early growth response 1	Homo sapiens	113-118
18292803-6	2008	Further investigation demonstrated that curcumin abrogated histone acetylation, GATA4 acetylation, and DNA-binding activity through blocking p300-HAT activity.	Curcumin	40-48	E1A binding protein p300	Mus musculus	141-145
18292803-7	2008	Curcumin also blocked AB-induced inflammation and fibrosis through disrupting p300-HAT-dependent signaling pathways.	Curcumin	0-8	E1A binding protein p300	Mus musculus	78-82
18316600-8	2008	In addition, stable knockdown of Egr-1 expression in U-87MG cells suppressed curcumin-induced p21 expression.	Curcumin	77-85	early growth response 1	Homo sapiens	33-38
18292803-8	2008	Our results indicate that curcumin has the potential to protect against cardiac hypertrophy, inflammation, and fibrosis through suppression of p300-HAT activity and downstream GATA4, NF-kappaB, and TGF-beta-Smad signaling pathways.	Curcumin	26-34	E1A binding protein p300	Mus musculus	143-147
18316600-9	2008	Our results indicate that ERK and JNK MAPK/Elk-1/Egr-1 signal cascade is required for p53-independent transcriptional activation of p21(Waf1/Cip1) in response to curcumin in U-87MG human glioblastoma cells.	Curcumin	162-170	early growth response 1	Homo sapiens	49-54
18683733-6	2008	RESULTS: Curcumin reduced the activities of MMP-2 and MMP-9 on a dose-dependent manner.	Curcumin	9-17	matrix metallopeptidase 9	Homo sapiens	54-59
18006644-6	2008	Curcumin dramatically suppresses inflammation by reducing levels of inflammatory cytokines, including interferon-gamma, tumor necrosis factor-alpha, and interleukin-6.	Curcumin	0-8	interferon gamma	Rattus norvegicus	102-147
18683733-8	2008	CONCLUSIONS: Curcumin can suppress Tca8113 invasion and migration by reducing the activities of MMP-2 and MMP-9.	Curcumin	13-21	matrix metallopeptidase 9	Homo sapiens	106-111
18006147-3	2008	Here, we demonstrate that curcumin down-regulates P-gp expression in multidrug-resistant L1210/Adr cells.	Curcumin	26-34	phosphoglycolate phosphatase	Mus musculus	50-54
18006147-7	2008	Thus, curcumin can contribute to the reversal of the MDR phenotype, probably due to the suppression of P-gp expression via the inhibition of the PI3K/Akt/NF-kappa B signaling pathway.	Curcumin	6-14	phosphoglycolate phosphatase	Mus musculus	103-107
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	BCL2-antagonist/killer 1	Mus musculus	95-98
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	proline-rich acidic protein 1	Mus musculus	212-215
18389075-8	2008	When muscles from septic rats were treated with curcumin in vitro, proteasome-, calpain-, and cathepsin L-dependent protein breakdown rates were reduced, and nuclear NF-kappaB/p65 expression and activity as well as levels of phosphorylated (activated) p38 were decreased.	Curcumin	48-56	cathepsin L	Rattus norvegicus	94-105
18497527-11	2008	The expression of VEGF in the corneal tissues was inhibited by curcumin on days 7 and 14 after alkaline burn.	Curcumin	63-71	vascular endothelial growth factor A	Rattus norvegicus	18-22
17918158-0	2008	Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R.	Curcumin	0-8	insulin like growth factor 1 receptor	Homo sapiens	140-146
17918158-8	2008	We conclude that the superior effects of the combination therapy of curcumin and FOLFOX are due to attenuation of EGFRs and IGF-1R signaling pathways.	Curcumin	68-76	insulin like growth factor 1 receptor	Homo sapiens	124-130
18156803-5	2007	Curcumin induced the expression of cyclin-dependent kinase (CDK) inhibitors p16(/INK4a), p21(/WAF1/CIP1) and p27(/KIP1), and inhibited the expression of cyclin E and cyclin D1, and hyperphosphorylation of retinoblastoma (Rb) protein.	Curcumin	0-8	interferon alpha inducible protein 27	Homo sapiens	109-112
18379992-0	2008	CD147 regulates vascular endothelial growth factor-A expression, tumorigenicity, and chemosensitivity to curcumin in hepatocellular carcinoma.	Curcumin	105-113	basigin	Mus musculus	0-5
18379992-7	2008	Furthermore, the downregulation of CD147 expression also sensitized cells to be more sensitive to curcumin.	Curcumin	98-106	basigin	Mus musculus	35-40
18156803-5	2007	Curcumin induced the expression of cyclin-dependent kinase (CDK) inhibitors p16(/INK4a), p21(/WAF1/CIP1) and p27(/KIP1), and inhibited the expression of cyclin E and cyclin D1, and hyperphosphorylation of retinoblastoma (Rb) protein.	Curcumin	0-8	cyclin dependent kinase inhibitor 1B	Homo sapiens	114-118
18227041-7	2008	Curcumin treatment resulted in significantly decreased DAI, CMDI, HS and lowered activities of D-lactate, ICAM-1 and MPO in comparison with the model group (P&lt;0.01).	Curcumin	0-8	intercellular adhesion molecule 1	Rattus norvegicus	106-112
17880909-3	2007	In the nucleus, curcumin inhibited the TCDD-induced heterodimerization of the AhR with an AhR nuclear translocator (Arnt), an essential partner for the transformation, and also dose-dependently inhibited the TCDD-evoked phosphorylation of both the AhR and Arnt.	Curcumin	16-24	aryl hydrocarbon receptor nuclear translocator	Mus musculus	90-114
17975885-8	2007	GSTT1-1 hardly catalyzes the glutathione conjugation of curcumin.	Curcumin	56-64	glutathione S-transferase theta 1	Homo sapiens	0-7
17880909-3	2007	In the nucleus, curcumin inhibited the TCDD-induced heterodimerization of the AhR with an AhR nuclear translocator (Arnt), an essential partner for the transformation, and also dose-dependently inhibited the TCDD-evoked phosphorylation of both the AhR and Arnt.	Curcumin	16-24	aryl hydrocarbon receptor nuclear translocator	Mus musculus	116-120
17880909-3	2007	In the nucleus, curcumin inhibited the TCDD-induced heterodimerization of the AhR with an AhR nuclear translocator (Arnt), an essential partner for the transformation, and also dose-dependently inhibited the TCDD-evoked phosphorylation of both the AhR and Arnt.	Curcumin	16-24	aryl hydrocarbon receptor nuclear translocator	Mus musculus	256-260
18290715-12	2007	Activation of VDR by PUFAs and curcumin may elicit unique, 1,25(OH)(2)D(3)-independent signaling pathways to orchestrate the bioeffects of these lipids in intestine, bone, skin/hair follicle, and other VDR-containing tissues.	Curcumin	31-39	vitamin D receptor	Homo sapiens	14-17
17880909-4	2007	Moreover, curcumin significantly inhibited the TCDD-induced activation of protein kinase C (PKC), which is involved in the transformation, decreased the TCDD-induced DNA-binding activity of the AhR/Arnt heterodimer, and downregulated CYP1A1 expression.	Curcumin	10-18	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	198-202
18290715-12	2007	Activation of VDR by PUFAs and curcumin may elicit unique, 1,25(OH)(2)D(3)-independent signaling pathways to orchestrate the bioeffects of these lipids in intestine, bone, skin/hair follicle, and other VDR-containing tissues.	Curcumin	31-39	vitamin D receptor	Homo sapiens	202-205
17880909-4	2007	Moreover, curcumin significantly inhibited the TCDD-induced activation of protein kinase C (PKC), which is involved in the transformation, decreased the TCDD-induced DNA-binding activity of the AhR/Arnt heterodimer, and downregulated CYP1A1 expression.	Curcumin	10-18	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	234-240
17885582-9	2007	Curcumin induced melanoma cells to undergo apoptosis, as shown by caspase-3 activation, inversion of membrane phosphatidyl serine, and increases in cells in the sub-G1 phase.	Curcumin	0-8	caspase 3	Mus musculus	66-75
17885582-10	2007	A curcumin dose-dependent inhibition of NF-kappaB-driven reporter activity correlated with decreased levels of phospho-IkappaBalpha, and decreased expression of NF-kappaB-target genes COX-2 and cyclin D1.	Curcumin	2-10	cyclin D1	Mus musculus	194-203
17880909-6	2007	These results indicate that curcumin is able to bind to the AhR as a ligand, but suppresses its transformation by inhibiting the phosphorylation of AhR and Arnt, probably by PKC.	Curcumin	28-36	aryl hydrocarbon receptor nuclear translocator	Mus musculus	156-160
17979888-3	2007	Curcumin has been shown to exhibit an inhibitory effect on the production of inflammatory cytokines by human monocytes and has inhibited the animal model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE) in association with a decrease in interleukin 12 (IL-12) production and signal transducer and activator of transcription 4 (STAT4) activation.	Curcumin	0-8	signal transducer and activator of transcription 4	Homo sapiens	302-352
17916240-5	2007	Overexpression of dominant negative FADD inhibited the interactive effects of curcumin and TRAIL on apoptosis.	Curcumin	78-86	Fas associated via death domain	Homo sapiens	36-40
17979888-3	2007	Curcumin has been shown to exhibit an inhibitory effect on the production of inflammatory cytokines by human monocytes and has inhibited the animal model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE) in association with a decrease in interleukin 12 (IL-12) production and signal transducer and activator of transcription 4 (STAT4) activation.	Curcumin	0-8	signal transducer and activator of transcription 4	Homo sapiens	354-359
17979888-7	2007	We report that curcumin decreases IL-12-induced STAT4 phosphorylation, IFN-gamma production, and IL-12 Rbeta1 and beta2 expression.	Curcumin	15-23	signal transducer and activator of transcription 4	Homo sapiens	48-53
17979888-8	2007	IFN-beta-induced STAT4 phosphorylation, IL-10 production and IFN receptor (IFNAR) subunits 1 and 2 expression were enhanced by curcumin.	Curcumin	127-135	signal transducer and activator of transcription 4	Homo sapiens	17-22
17916240-6	2007	Treatment of these cells with curcumin resulted in activation of caspase-3, and caspase-9, and drop in mitochondrial membrane potential, and these events were further enhanced when combined with TRAIL.	Curcumin	30-38	caspase 9	Homo sapiens	80-89
17979888-8	2007	IFN-beta-induced STAT4 phosphorylation, IL-10 production and IFN receptor (IFNAR) subunits 1 and 2 expression were enhanced by curcumin.	Curcumin	127-135	interleukin 10	Homo sapiens	40-45
17979888-9	2007	Curcumin increased IFN-alpha-induced IL-10 and IFNAR1 expression.	Curcumin	0-8	interleukin 10	Homo sapiens	37-42
17979888-10	2007	Prior exposure to curcumin decreased IFN-alpha-induced IFNAR2 expression and did not modify the level of IFN-alpha-induced pSTAT4 generation.	Curcumin	18-26	interferon alpha and beta receptor subunit 2	Homo sapiens	55-61
17916240-7	2007	Curcumin inhibited capillary tube formation and migration of HUVEC cells and these effects were further enhanced in the presence of MEK1/2 inhibitor PD98059.	Curcumin	0-8	mitogen-activated protein kinase kinase 1	Homo sapiens	132-138
17590421-0	2007	Curcumin down-regulates Ets-1 and Bcl-2 expression in human endometrial carcinoma HEC-1-A cells.	Curcumin	0-8	ETS proto-oncogene 1, transcription factor	Homo sapiens	24-29
17590421-2	2007	The present study was undertaken to determine the effect of curcumin on the expression of the proto-oncogene Ets-1 and the anti-apoptotic molecule Bcl-2 in human endometrial adenocarcinoma HEC-1-A cells.	Curcumin	60-68	ETS proto-oncogene 1, transcription factor	Homo sapiens	109-114
17979888-11	2007	Thus, the effect of curcumin on STAT4 activation in T cells is dependent upon the stimulus to which the T cells have been exposed.	Curcumin	20-28	signal transducer and activator of transcription 4	Homo sapiens	32-37
17590421-5	2007	As an initial step towards understanding whether Ets-1 was a possible up-stream regulator of Bcl-2 expression in HEC-1-A cells and if so, whether curcumin could attenuate the Ets-1-induced up-regulation of Bcl-2 expression, cells were transiently transfected with an Ets-1/GFP (Green Fluorescence Protein) fusion construct and the transfectants were treated with 60 microM curcumin for 16 h, followed by whole cell lysate preparation for Western blot analysis of Bcl-2 protein contents.	Curcumin	146-154	ETS proto-oncogene 1, transcription factor	Homo sapiens	175-180
17590421-5	2007	As an initial step towards understanding whether Ets-1 was a possible up-stream regulator of Bcl-2 expression in HEC-1-A cells and if so, whether curcumin could attenuate the Ets-1-induced up-regulation of Bcl-2 expression, cells were transiently transfected with an Ets-1/GFP (Green Fluorescence Protein) fusion construct and the transfectants were treated with 60 microM curcumin for 16 h, followed by whole cell lysate preparation for Western blot analysis of Bcl-2 protein contents.	Curcumin	146-154	ETS proto-oncogene 1, transcription factor	Homo sapiens	175-180
17640182-5	2007	Macroscopic damage score, histological damage score and colonic myeloperoxidase (MPO) activity were significantly lower (by 71%, 65% and 73%, respectively; P &lt; 0.01), in animals treated with curcumin compared with untreated animals.	Curcumin	194-202	myeloperoxidase	Mus musculus	64-79
17640182-5	2007	Macroscopic damage score, histological damage score and colonic myeloperoxidase (MPO) activity were significantly lower (by 71%, 65% and 73%, respectively; P &lt; 0.01), in animals treated with curcumin compared with untreated animals.	Curcumin	194-202	myeloperoxidase	Mus musculus	81-84
17590421-6	2007	RESULTS: Curcumin induced apoptosis-like morphological changes and DNA degradation and decreased basal levels of Ets-1 and Bcl-2 protein contents in HEC-1-A cells in a time- and dose-dependent manner.	Curcumin	9-17	ETS proto-oncogene 1, transcription factor	Homo sapiens	113-118
17666914-6	2007	The expression of intracellular cell adhesion molecule (ICAM)-1, monocyte chemoattractant protein (MCP)-1, and interleukin (IL)-8 were attenuated by curcumin at both mRNA and protein level.	Curcumin	149-157	intercellular adhesion molecule 1	Homo sapiens	18-63
17590421-7	2007	Overexpression of Ets-1 in the cell resulted in an increase in Bcl-2 protein contents and that increase was attenuated by curcumin treatment.	Curcumin	122-130	ETS proto-oncogene 1, transcription factor	Homo sapiens	18-23
17596214-7	2007	Curcumin-sensitized glioma cells to several clinically utilized chemotherapeutic agents (cisplatin, etoposide, camptothecin, and doxorubicin) and radiation, effects correlated with reduced expression of bcl-2 and IAP family members as well as DNA repair enzymes (MGMT, DNA-PK, Ku70, Ku80, and ERCC-1).	Curcumin	0-8	O-6-methylguanine-DNA methyltransferase	Homo sapiens	263-267
17590421-8	2007	CONCLUSIONS: Curcumin down-regulates Ets-1 and Bcl-2 expression and induces apoptosis in HEC-1-A cells, suggesting a novel molecular mechanism for the anti-tumor activity of curcumin.	Curcumin	13-21	ETS proto-oncogene 1, transcription factor	Homo sapiens	37-42
17596214-7	2007	Curcumin-sensitized glioma cells to several clinically utilized chemotherapeutic agents (cisplatin, etoposide, camptothecin, and doxorubicin) and radiation, effects correlated with reduced expression of bcl-2 and IAP family members as well as DNA repair enzymes (MGMT, DNA-PK, Ku70, Ku80, and ERCC-1).	Curcumin	0-8	X-ray repair cross complementing 6	Homo sapiens	277-281
17590421-8	2007	CONCLUSIONS: Curcumin down-regulates Ets-1 and Bcl-2 expression and induces apoptosis in HEC-1-A cells, suggesting a novel molecular mechanism for the anti-tumor activity of curcumin.	Curcumin	174-182	ETS proto-oncogene 1, transcription factor	Homo sapiens	37-42
17277231-0	2007	Bax and Bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, Curcuma longa.	Curcumin	66-74	BCL2-associated X protein	Mus musculus	0-3
17640567-5	2007	The reducing agent also counteracted the inhibitory effects of curcumin on TNF-induced NF-kappaB-regulated antiapoptotic (Bcl-2, Bcl-xL, IAP1), proliferative (cyclin D1), and proinflammatory (COX-2, iNOS, and MMP-9) gene products.	Curcumin	63-71	baculoviral IAP repeat containing 3	Homo sapiens	137-141
17277231-2	2007	The objective of this study was to examine the molecular mechanisms by which multidomain pro-apoptotic Bcl-2 family members Bax and Bak regulate curcumin-induced apoptosis using mouse embryonic fibroblasts (MEFs) deficient in Bax, Bak or both genes.	Curcumin	145-153	BCL2-associated X protein	Mus musculus	124-127
17277231-3	2007	Curcumin treatment resulted an increase in the protein levels of both Bax and Bak, and mitochondrial translocation and activation of Bax in MEFs to trigger drop in mitochondrial membrane potential, cytosolic release of apoptogenic molecules [cytochrome c and second mitochondria-derived activator of caspases (Smac)/direct inhibitor of apoptosis protein-binding protein with low isoelectric point], activation of caspase-9 and caspase-3 and ultimately apoptosis.	Curcumin	0-8	BCL2-associated X protein	Mus musculus	70-73
17640567-5	2007	The reducing agent also counteracted the inhibitory effects of curcumin on TNF-induced NF-kappaB-regulated antiapoptotic (Bcl-2, Bcl-xL, IAP1), proliferative (cyclin D1), and proinflammatory (COX-2, iNOS, and MMP-9) gene products.	Curcumin	63-71	inositol-3-phosphate synthase 1	Homo sapiens	199-203
17277231-3	2007	Curcumin treatment resulted an increase in the protein levels of both Bax and Bak, and mitochondrial translocation and activation of Bax in MEFs to trigger drop in mitochondrial membrane potential, cytosolic release of apoptogenic molecules [cytochrome c and second mitochondria-derived activator of caspases (Smac)/direct inhibitor of apoptosis protein-binding protein with low isoelectric point], activation of caspase-9 and caspase-3 and ultimately apoptosis.	Curcumin	0-8	BCL2-associated X protein	Mus musculus	133-136
17277231-3	2007	Curcumin treatment resulted an increase in the protein levels of both Bax and Bak, and mitochondrial translocation and activation of Bax in MEFs to trigger drop in mitochondrial membrane potential, cytosolic release of apoptogenic molecules [cytochrome c and second mitochondria-derived activator of caspases (Smac)/direct inhibitor of apoptosis protein-binding protein with low isoelectric point], activation of caspase-9 and caspase-3 and ultimately apoptosis.	Curcumin	0-8	caspase 3	Mus musculus	427-436
17277231-4	2007	Furthermore, MEFs derived from Bax and Bak double-knockout (DKO) mice exhibited even greater protection against curcumin-induced release of cytochrome c and Smac, activation of caspase-3 and caspase-9 and induction of apoptosis compared with wild-type MEFs or single-knockout Bax(-/-) or Bak(-/-) MEFs.	Curcumin	112-120	BCL2-associated X protein	Mus musculus	31-34
17277231-4	2007	Furthermore, MEFs derived from Bax and Bak double-knockout (DKO) mice exhibited even greater protection against curcumin-induced release of cytochrome c and Smac, activation of caspase-3 and caspase-9 and induction of apoptosis compared with wild-type MEFs or single-knockout Bax(-/-) or Bak(-/-) MEFs.	Curcumin	112-120	caspase 3	Mus musculus	177-186
17555831-6	2007	Furthermore, exosomes isolated from tumor cells pretreated with curcumin have a much attenuated inhibition of IL-2 stimulated NK cell activation.	Curcumin	64-72	interleukin 2	Mus musculus	110-114
17277231-4	2007	Furthermore, MEFs derived from Bax and Bak double-knockout (DKO) mice exhibited even greater protection against curcumin-induced release of cytochrome c and Smac, activation of caspase-3 and caspase-9 and induction of apoptosis compared with wild-type MEFs or single-knockout Bax(-/-) or Bak(-/-) MEFs.	Curcumin	112-120	BCL2-associated X protein	Mus musculus	276-279
17555831-8	2007	TS/A tumor exosomes strongly inhibit activation of Stat5, whereas the tumor exosomes isolated from curcumin-pretreated tumor cells have a lowered potency for inhibition of IL-2 stimulated NK cell cytotoxicity.	Curcumin	99-107	interleukin 2	Mus musculus	172-176
17299794-7	2007	Moreover, pretreatment with p300 inhibitor (curcumin) also blocked ICAM-1 expression.	Curcumin	44-52	intercellular adhesion molecule 1	Homo sapiens	67-73
17171638-7	2007	Curcumin increased the expression of the phosphorylated forms of PTK, PDK1, and PKC-delta, which was attenuated by either GSH or NAC and potentiated by BSO.	Curcumin	0-8	pyruvate dehydrogenase kinase 1	Homo sapiens	70-74
17277231-8	2007	The present study demonstrates the role of Bax and Bak as a critical regulator of curcumin-induced apoptosis and over-expression of Smac as interventional approaches to deal with Bax- and/or Bak-deficient chemoresistant cancers for curcumin-based therapy.	Curcumin	82-90	BCL2-antagonist/killer 1	Mus musculus	51-54
17291458-0	2007	Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis.	Curcumin	39-47	matrix metallopeptidase 9	Homo sapiens	107-133
17291458-11	2007	Curcumin also reversed the IL-1beta-induced down-regulation of collagen type II and beta1-integrin receptor expression.	Curcumin	0-8	integrin subunit beta 1	Homo sapiens	84-98
17277231-8	2007	The present study demonstrates the role of Bax and Bak as a critical regulator of curcumin-induced apoptosis and over-expression of Smac as interventional approaches to deal with Bax- and/or Bak-deficient chemoresistant cancers for curcumin-based therapy.	Curcumin	232-240	BCL2-antagonist/killer 1	Mus musculus	51-54
17499312-8	2007	Curcumin decreased the secretion of IGF-1 with a concomitant increase of IGFBP-3 in a dose-dependent manner.	Curcumin	0-8	insulin like growth factor binding protein 3	Homo sapiens	73-80
17499312-9	2007	Receptor tyrosine kinase assays revealed that IGF-1-stimulated IGF-1R tyrosine kinase activation was also abrogated by curcumin in a dose-dependent manner.	Curcumin	119-127	ret proto-oncogene	Homo sapiens	0-24
17300872-7	2007	In addition, curcumin treatment reduced the KA-induced immunoreactivity of caspase-3.	Curcumin	13-21	caspase 3	Mus musculus	75-84
17449203-0	2007	Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element.	Curcumin	0-8	glutathione S-transferase pi 1	Homo sapiens	25-53
17131042-6	2007	Curcumin, a natural inhibitor of JNK signaling, protected the HT22 cells from glutamate-induced death at nanomolar concentrations more efficiently than SP600125.	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	33-36
17131042-7	2007	These doses of curcumin affected neither the level of intracellular glutathione nor the level of reactive oxygen species, but inactivated JNK and p38 significantly.	Curcumin	15-23	mitogen-activated protein kinase 8	Mus musculus	138-141
17131042-8	2007	Moreover, curcumin markedly upregulated a cell-cycle inhibitory protein, p21cip1, and downregulated cyclin D1 levels, which might help the cell death prevention.	Curcumin	10-18	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	73-80
17131042-8	2007	Moreover, curcumin markedly upregulated a cell-cycle inhibitory protein, p21cip1, and downregulated cyclin D1 levels, which might help the cell death prevention.	Curcumin	10-18	cyclin D1	Mus musculus	100-109
17449203-4	2007	In this study, we demonstrated that curcumin could induce the expression of human glutathione S-transferase P1 (GSTP1).	Curcumin	36-44	glutathione S-transferase pi 1	Homo sapiens	82-110
17303007-0	2007	Curcumin downregulates homeobox gene NKX3.1 in prostate cancer cell LNCaP.	Curcumin	0-8	NK3 homeobox 1	Homo sapiens	37-43
17449203-4	2007	In this study, we demonstrated that curcumin could induce the expression of human glutathione S-transferase P1 (GSTP1).	Curcumin	36-44	glutathione S-transferase pi 1	Homo sapiens	112-117
17303007-1	2007	AIM: To elucidate the effect and the mechanisms of curcumin on the expression of the human homeobox gene NKX3.1 in the prostate cancer cell LNCaP.	Curcumin	51-59	NK3 homeobox 1	Homo sapiens	105-111
17449203-5	2007	In HepG2 cells treated with 20muM curcumin, the level of GSTP1 mRNA was significantly increased.	Curcumin	34-42	glutathione S-transferase pi 1	Homo sapiens	57-62
17303007-2	2007	METHODS: The expression change of NKX3.1 in cells incubated with varying concentrations of curcumin was observed by Western blotting and RT-PCR.	Curcumin	91-99	NK3 homeobox 1	Homo sapiens	34-40
17303007-3	2007	A dual luciferase reporter assay was used to test the effect of curcumin on the activity of the NKX3.1 1040 bp promoter.	Curcumin	64-72	NK3 homeobox 1	Homo sapiens	96-102
17303007-4	2007	Curcumin-treated cells disposed to a designated amount of androgen analog R1881 and the androgen receptor (AR) antagonist flutamide, then the expression of NKX3.1 or the activity of the NKX3.1 promoter were investigated by Western blotting or reporter gene assay, respectively.	Curcumin	0-8	NK3 homeobox 1	Homo sapiens	156-162
17449203-10	2007	In a gel mobility shift assay with an oligonucleotide with GSTP1 ARE, an increase in the amount of the binding complex was observed in the nuclear extracts of curcumin-treated HepG2 cells.	Curcumin	159-167	glutathione S-transferase pi 1	Homo sapiens	59-64
17303007-4	2007	Curcumin-treated cells disposed to a designated amount of androgen analog R1881 and the androgen receptor (AR) antagonist flutamide, then the expression of NKX3.1 or the activity of the NKX3.1 promoter were investigated by Western blotting or reporter gene assay, respectively.	Curcumin	0-8	NK3 homeobox 1	Homo sapiens	186-192
17449203-11	2007	These results suggested that ARE is the primary sequence for the curcumin-induced transactivation of the GSTP1 gene.	Curcumin	65-73	glutathione S-transferase pi 1	Homo sapiens	105-110
17332326-0	2007	Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway.	Curcumin	0-8	MDM2 proto-oncogene	Homo sapiens	121-125
17332326-2	2007	We have identified curcumin, which has previously been shown to have anticancer activity, as an inhibitor of MDM2 expression.	Curcumin	19-27	MDM2 proto-oncogene	Homo sapiens	109-113
17449203-12	2007	The induction of GSTP1 may be one of the mechanisms underlying the multiple actions of curcumin.	Curcumin	87-95	glutathione S-transferase pi 1	Homo sapiens	17-22
17531121-17	2007	Hoechst 33258 staining showed that curcumin induced the apoptosis of culture-activated HSCs and significantly increased pro-apoptotic Bax expression and reduced anti-apoptotic Bcl-2 expression.	Curcumin	35-43	BCL2 associated X, apoptosis regulator	Rattus norvegicus	134-137
17372590-0	2007	The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro.	Curcumin	59-67	epidermal growth factor	Rattus norvegicus	33-36
17372590-5	2007	It is hypothesized that the interruption of the PDGF and EGF signaling pathways by curcumin might stimulate gene expression of PPARgamma in activated HSC.	Curcumin	83-91	epidermal growth factor	Rattus norvegicus	57-60
17437639-9	2007	Curcumin also inhibited diabetes-induced elevation in the levels of IL-1beta, VEGF and NF-kB.	Curcumin	0-8	vascular endothelial growth factor A	Rattus norvegicus	78-82
17437639-9	2007	Curcumin also inhibited diabetes-induced elevation in the levels of IL-1beta, VEGF and NF-kB.	Curcumin	0-8	nuclear factor kappa B subunit 1	Rattus norvegicus	87-92
17240359-0	2007	Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.	Curcumin	0-8	interferon alpha inducible protein 27	Homo sapiens	152-155
17240359-6	2007	We found that curcumin enhanced the expression of tumor cyclin-dependent kinase (CDK) inhibitors p21 and p27 as well as tumor suppressor protein p53 but suppressed the expression of retinoblastoma protein.	Curcumin	14-22	interferon alpha inducible protein 27	Homo sapiens	105-108
17332930-7	2007	Treatment of LNCaP cells with curcumin resulted in translocation of Bax and p53 to mitochondria, production of reactive oxygen species, drop in mitochondrial membrane potential, release of mitochondrial proteins (cytochrome c, Smac/DIABLO and Omi/HtrA2), activation of caspase-3 and induction of apoptosis.	Curcumin	30-38	diablo IAP-binding mitochondrial protein	Homo sapiens	227-231
17332930-7	2007	Treatment of LNCaP cells with curcumin resulted in translocation of Bax and p53 to mitochondria, production of reactive oxygen species, drop in mitochondrial membrane potential, release of mitochondrial proteins (cytochrome c, Smac/DIABLO and Omi/HtrA2), activation of caspase-3 and induction of apoptosis.	Curcumin	30-38	diablo IAP-binding mitochondrial protein	Homo sapiens	232-238
17332930-7	2007	Treatment of LNCaP cells with curcumin resulted in translocation of Bax and p53 to mitochondria, production of reactive oxygen species, drop in mitochondrial membrane potential, release of mitochondrial proteins (cytochrome c, Smac/DIABLO and Omi/HtrA2), activation of caspase-3 and induction of apoptosis.	Curcumin	30-38	HtrA serine peptidase 2	Homo sapiens	247-252
17332326-4	2007	In a human prostate cancer cell lines PC3 (p53(null)), curcumin reduced MDM2 protein and mRNA in a dose- and time-dependent manner, and enhanced the expression of the tumor suppressor p21(Waf1/CIP1).	Curcumin	55-63	proprotein convertase subtilisin/kexin type 1	Homo sapiens	38-41
17332326-6	2007	Curcumin induced apoptosis and inhibited proliferation of PC3 cells in culture, but both MDM2 overexpression and knockdown reduced these effects.	Curcumin	0-8	proprotein convertase subtilisin/kexin type 1	Homo sapiens	58-61
17273730-6	2007	Furthermore, combination of UVB irradiation with curcumin synergistically induces apoptotic cell death in HaCaT cells through activation of caspase-8, and -3 as well as caspase-9 activation followed by release of cytochrome c.	Curcumin	49-57	caspase 9	Homo sapiens	169-178
17572999-15	2007	(6) The concentrations of IFN-gamma in BALF in the curcumin group and the bleomycin group were 0.49 +/- 0.17, 0.50 +/- 0.08 at day 21, and 0.52 +/- 0.15, 0.52 +/- 0.11 at day 28, all being not statistically different between the two groups (q = 1.85, 2.03, all P &gt; 0.05).	Curcumin	51-59	interferon gamma	Rattus norvegicus	26-35
17572999-16	2007	(7) The expression of IFN-gamma mRNA in the curcumin group and the bleomycin group were (28 +/- 5) ng/L, (35 +/- 13) ng/L at day 21, and (30 +/- 11) ng/L, (39 +/- 13) ng/L at day 28, no significant difference between the two groups (q = 0.17, 0.00, all P &gt; 0.05).	Curcumin	44-52	interferon gamma	Rattus norvegicus	22-31
17178109-0	2007	Curcumin enhances cystic fibrosis transmembrane regulator expression by down-regulating calreticulin.	Curcumin	0-8	calreticulin	Cricetulus griseus	88-100
17178109-1	2007	Curcumin has been reported to correct cystic fibrosis caused by the DeltaF508 mutation of the cystic fibrosis transmembrane regulator (CFTR) but its mechanistic action remains unclear.	Curcumin	0-8	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	135-139
17178109-3	2007	Thus, we aimed at determining whether CRT mediates the effect of curcumin on CFTR.	Curcumin	65-73	calreticulin	Cricetulus griseus	38-41
17178109-3	2007	Thus, we aimed at determining whether CRT mediates the effect of curcumin on CFTR.	Curcumin	65-73	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	77-81
17178109-4	2007	We show here that the treatment with curcumin of Chinese hamster ovary cells suppressed CRT expression and increased wild-type CFTR but did not affect DeltaF508 CFTR expression.	Curcumin	37-45	calreticulin	Cricetulus griseus	88-91
17178109-4	2007	We show here that the treatment with curcumin of Chinese hamster ovary cells suppressed CRT expression and increased wild-type CFTR but did not affect DeltaF508 CFTR expression.	Curcumin	37-45	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	127-131
17178109-5	2007	However, we determined that although curcumin did not augment DeltaF508 CFTR expression, it enhanced the functional competence of DeltaF508 CFTR induced by 26 degrees C incubation.	Curcumin	37-45	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	140-144
17178109-7	2007	Our findings suggest that the positive effect of curcumin on CFTR expression is mediated through the down-regulation of CRT, a negative regulator of CFTR.	Curcumin	49-57	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	61-65
17178109-7	2007	Our findings suggest that the positive effect of curcumin on CFTR expression is mediated through the down-regulation of CRT, a negative regulator of CFTR.	Curcumin	49-57	calreticulin	Cricetulus griseus	120-123
17178109-7	2007	Our findings suggest that the positive effect of curcumin on CFTR expression is mediated through the down-regulation of CRT, a negative regulator of CFTR.	Curcumin	49-57	cystic fibrosis transmembrane conductance regulator	Cricetulus griseus	149-153
17046132-4	2007	Using 1-chloro-2,4 dinitrobenzene (CDNB) as a substrate, ellagic acid and curcumin were shown to inhibit GSTs A1-1, A2-2, M1-1, M2-2 and P1-1 with IC(50) values ranging from 0.04 to 5 microM whilst genistein, kaempferol and quercetin inhibited GSTs M1-1 and M2-2 only.	Curcumin	74-82	glutathione S-transferase kappa 1	Homo sapiens	244-248
17046132-7	2007	Ellagic acid and curcumin also showed time- and concentration-dependent inactivation of GSTs M1-1, M2-2 and P1-1 with curcumin being a more potent inactivator than ellagic acid.	Curcumin	17-25	glutathione S-transferase kappa 1	Homo sapiens	88-92
17046132-7	2007	Ellagic acid and curcumin also showed time- and concentration-dependent inactivation of GSTs M1-1, M2-2 and P1-1 with curcumin being a more potent inactivator than ellagic acid.	Curcumin	118-126	glutathione S-transferase kappa 1	Homo sapiens	88-92
16947318-3	2007	As curcumin has been reported to inhibit the NIK/IKK complex, an activity that would be expected to induce apoptosis in B cell malignancies, we sought to determine whether curcumin induces apoptosis in vitro in primary chronic lymphocytic leukemia (B-CLL) cells.	Curcumin	3-11	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	45-48
16959952-10	2007	Promoter deletion assays, site-directed mutageneses, and gel shift assays localize two Smad binding elements (SBEs) in the PPAR-gamma gene promoter, acting as curcumin response elements and negatively regulating the promoter activity in passaged HSC.	Curcumin	159-167	SMAD family member 4	Rattus norvegicus	87-91
16959952-12	2007	Overexpression of Smad4 dose dependently eliminates the inhibitory effects of curcumin on the PPAR-gamma gene promoter and TGF-beta signaling.	Curcumin	78-86	SMAD family member 4	Rattus norvegicus	18-23
17217587-1	2006	The chemical degradation of curcumin (CU) in aqueous solution and on silver nanoparticles was studied by means of ultraviolet (UV)-visible absorption and surface-enhanced Raman (SERS) spectroscopy at different pH levels and upon light irradiation.	Curcumin	28-36	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	178-182
17217587-1	2006	The chemical degradation of curcumin (CU) in aqueous solution and on silver nanoparticles was studied by means of ultraviolet (UV)-visible absorption and surface-enhanced Raman (SERS) spectroscopy at different pH levels and upon light irradiation.	Curcumin	38-40	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	178-182
16959222-4	2006	Most interestingly, the decrease of nuclear STAT5a and -5b after curcumin treatment was accompanied by an increase of truncated STAT5 isoforms, indicating that curcumin is able to induce the cleavage of STAT5 into its dominant negative variants lacking the STAT5 C-terminal region.	Curcumin	65-73	signal transducer and activator of transcription 5A	Homo sapiens	44-58
16959222-4	2006	Most interestingly, the decrease of nuclear STAT5a and -5b after curcumin treatment was accompanied by an increase of truncated STAT5 isoforms, indicating that curcumin is able to induce the cleavage of STAT5 into its dominant negative variants lacking the STAT5 C-terminal region.	Curcumin	65-73	signal transducer and activator of transcription 5A	Homo sapiens	44-49
16959222-4	2006	Most interestingly, the decrease of nuclear STAT5a and -5b after curcumin treatment was accompanied by an increase of truncated STAT5 isoforms, indicating that curcumin is able to induce the cleavage of STAT5 into its dominant negative variants lacking the STAT5 C-terminal region.	Curcumin	160-168	signal transducer and activator of transcription 5A	Homo sapiens	44-58
16959222-4	2006	Most interestingly, the decrease of nuclear STAT5a and -5b after curcumin treatment was accompanied by an increase of truncated STAT5 isoforms, indicating that curcumin is able to induce the cleavage of STAT5 into its dominant negative variants lacking the STAT5 C-terminal region.	Curcumin	160-168	signal transducer and activator of transcription 5A	Homo sapiens	44-49
16959222-4	2006	Most interestingly, the decrease of nuclear STAT5a and -5b after curcumin treatment was accompanied by an increase of truncated STAT5 isoforms, indicating that curcumin is able to induce the cleavage of STAT5 into its dominant negative variants lacking the STAT5 C-terminal region.	Curcumin	160-168	signal transducer and activator of transcription 5A	Homo sapiens	128-133
16959222-4	2006	Most interestingly, the decrease of nuclear STAT5a and -5b after curcumin treatment was accompanied by an increase of truncated STAT5 isoforms, indicating that curcumin is able to induce the cleavage of STAT5 into its dominant negative variants lacking the STAT5 C-terminal region.	Curcumin	160-168	signal transducer and activator of transcription 5A	Homo sapiens	128-133
17022948-0	2006	Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB.	Curcumin	0-8	cAMP responsive element binding protein 1	Rattus norvegicus	114-118
17022948-9	2006	Furthermore, these stress-induced decreases in BDNF and pCREB/CREB were also blocked by chronic curcumin administration (5 or 10 mg/kg, p.o.).	Curcumin	96-104	cAMP responsive element binding protein 1	Rattus norvegicus	57-61
16956363-8	2006	Dietary curcumin and capsaicin significantly decreased the activity of 5"-lipoxygenase activity in the polymorphonuclear lymphocytes in carrageenan-injected rats, the decrease being even higher in the case of combination of these two spice principles.	Curcumin	8-16	arachidonate 5-lipoxygenase	Rattus norvegicus	71-86
17399992-4	2007	The relationship between these transcription factors and IL-18 expression was confirmed using curcumin and PDTC, two inhibitors of NF-kappaB.	Curcumin	94-102	interleukin 18	Homo sapiens	57-62
17041101-7	2006	Analysis of the effects of the analogues on the expression of cancer-related genes usually affected by curcumin indicated that some induced the down-regulation of beta-catenin, Ki-ras, cyclin D1, c-Myc, and ErbB-2 at as low as one eighth the concentration at which curcumin normally has an effect.	Curcumin	265-273	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	196-201
17399992-5	2007	Our results show that UVB and curcumin or PDTC co-treatment led to a down-regulation of IL-18 expression associated with an inhibition of NF-kappaB DNA binding.	Curcumin	30-38	interleukin 18	Homo sapiens	88-93
16550606-3	2006	Here we show that curcumin inhibited growth of rhabdomyosarcoma cells (Rh1 and Rh30) (IC50 = 2-5 microM) and arrested cells in G1 phase of the cell cycle.	Curcumin	18-26	Rh blood group D antigen	Homo sapiens	79-83
17198877-0	2007	Gene-expression profiling during curcumin-induced apoptosis reveals downregulation of CXCR4.	Curcumin	33-41	C-X-C motif chemokine receptor 4	Homo sapiens	86-91
16550606-5	2006	At physiological concentrations (2.5 microM), curcumin rapidly inhibited phosphorylation of the mammalian target of rapamycin (mTOR) and its downstream effector molecules, p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), in a panel of cell lines (Rh1, Rh30, DU145, MCF-7 and Hela).	Curcumin	46-54	ribosomal protein S6 kinase B1	Homo sapiens	189-193
17198877-6	2007	RESULTS: Comprehensive transcriptional response is associated with curcumin treatment in HF4.9 cells, including differential expression of genes encoding apoptotic signaling proteins, tumor and metastasis suppressors, transcription and splicing factors, proteins involved in regulation of cell adhesion, migration (e.g., CXCR4), lymphoid development, or B-cell activation (e.g. CD20), and others.	Curcumin	67-75	C-X-C motif chemokine receptor 4	Homo sapiens	321-326
16550606-5	2006	At physiological concentrations (2.5 microM), curcumin rapidly inhibited phosphorylation of the mammalian target of rapamycin (mTOR) and its downstream effector molecules, p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), in a panel of cell lines (Rh1, Rh30, DU145, MCF-7 and Hela).	Curcumin	46-54	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	232-256
17198877-8	2007	Importantly, curcumin induced downregulation of CXCR4 protein also in other FL cell lines, and similar effect was observed upon prolonged incubation with low concentration of curcumin.	Curcumin	13-21	C-X-C motif chemokine receptor 4	Homo sapiens	48-53
17198877-8	2007	Importantly, curcumin induced downregulation of CXCR4 protein also in other FL cell lines, and similar effect was observed upon prolonged incubation with low concentration of curcumin.	Curcumin	175-183	C-X-C motif chemokine receptor 4	Homo sapiens	48-53
16550606-5	2006	At physiological concentrations (2.5 microM), curcumin rapidly inhibited phosphorylation of the mammalian target of rapamycin (mTOR) and its downstream effector molecules, p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), in a panel of cell lines (Rh1, Rh30, DU145, MCF-7 and Hela).	Curcumin	46-54	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	258-264
17198877-10	2007	CONCLUSIONS: To our knowledge this is the first study showing curcumin-induced downregulation of CXCR4, and at attainable in vivo concentration of the polyphenol.	Curcumin	62-70	C-X-C motif chemokine receptor 4	Homo sapiens	97-102
16550606-5	2006	At physiological concentrations (2.5 microM), curcumin rapidly inhibited phosphorylation of the mammalian target of rapamycin (mTOR) and its downstream effector molecules, p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), in a panel of cell lines (Rh1, Rh30, DU145, MCF-7 and Hela).	Curcumin	46-54	Rh blood group D antigen	Homo sapiens	298-302
16819191-5	2006	Curcumin significantly inhibited the binding of Stx and the production of Gb3 synthase (GalT6) mRNA in HT29 IECs stimulated with TNF-alpha and IL-1beta.	Curcumin	0-8	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	74-86
16819191-7	2006	Furthermore, curcumin significantly attenuated Stx-1 induced cell death and IL-8 expression.	Curcumin	13-21	syntaxin 1A	Homo sapiens	47-52
16819191-8	2006	In summary, these data link Gb3 expression in HT29 cells stimulated with TNF-alpha and IL-1beta and suggest that blocking of Stx-binding by curcumin may prevent the Stx-associated HUS.	Curcumin	140-148	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	28-31
16751071-6	2006	Additionally, curcumin significantly decreased mRNA expression of early responding cytokines (IL-1 IL-6, IL-18, TNF-alpha, and lymphotoxin-beta) and the fibrogenic cytokine, TGF-beta, in cutaneous tissues at 21 days postradiation.	Curcumin	14-22	lymphotoxin B	Mus musculus	127-143
17112893-0	2006	Curcumin inhibits in vitro MCP-1 release from mouse pancreatic islets.	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	27-32
16963807-0	2006	Regulation of LDL receptor expression by the effect of curcumin on sterol regulatory element pathway.	Curcumin	55-63	low density lipoprotein receptor	Homo sapiens	14-26
17112893-4	2006	The aim of this study was to examine the effect of curcumin on in vitro MCP-1 release from pancreatic islets.	Curcumin	51-59	chemokine (C-C motif) ligand 2	Mus musculus	72-77
17112893-6	2006	MCP-1 levels in culture supernates of islets with versus without curcumin treatment were measured by an ELISA assay.	Curcumin	65-73	chemokine (C-C motif) ligand 2	Mus musculus	0-5
17112893-7	2006	RESULTS: We observed that curcumin at the concentration of 20 micromol/L significantly decreased MCP-1 release from mouse islets compared to the control group (P = .005).	Curcumin	26-34	chemokine (C-C motif) ligand 2	Mus musculus	97-102
17112893-8	2006	In addition at both of 10 micromol/L and 20 micromol/L curcumin concentrations there was a decreased level of MCP-1 released from LPS-treated versus control islets (P = .01).	Curcumin	55-63	chemokine (C-C motif) ligand 2	Mus musculus	110-115
16934760-0	2006	TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin.	Curcumin	112-120	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-48
16934760-2	2006	A number of plant polyphenols including curcumin, a yellow compound in the spice turmeric, have been shown to inhibit the activation of AP-1.	Curcumin	40-48	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-140
16934760-4	2006	Multiple activities reported for curcumin, including inhibition of the stress-induced activation of AP-1, have been suggested to involve the anti-oxidant properties of curcumin.	Curcumin	33-41	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	100-104
16934760-4	2006	Multiple activities reported for curcumin, including inhibition of the stress-induced activation of AP-1, have been suggested to involve the anti-oxidant properties of curcumin.	Curcumin	168-176	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	100-104
16963807-1	2006	To investigate the molecular mechanisms of the effect of curcumin on up-regulation of LDL receptor expression, a sterol regulatory report system was established in Xenopus laevis oocytes by microinjection of a plasmid pLXRN-4SRE-fPA, in which green fluorescence protein (GFP) gene was constructed downstream from the sterol regulatory element-1 (SRE-1), in the nucleus of the oocytes.	Curcumin	57-65	low density lipoprotein receptor	Homo sapiens	86-98
16934760-5	2006	In the present study, a library of analogs of curcumin was screened for activity against the TPA-induced activation of AP-1 using the Panomics AP-1 Reporter 293 stable cell line which is designed for screening potential inhibitors.	Curcumin	46-54	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	119-123
16963807-5	2006	In conclusion, curcumin may up-regulate the expression of LDL receptor by its effect on SRE pathway.	Curcumin	15-23	low density lipoprotein receptor	Homo sapiens	58-70
16904830-7	2006	The fluorescence of curcumin in EL4 lymphoma cells was found to be significantly higher as compared to the lymphocytes.	Curcumin	20-28	epilepsy 4	Mus musculus	32-35
16678799-7	2006	These results imply that curcumin inhibits both MyD88- and TRIF-dependent pathways in LPS-induced TLR4 signaling.	Curcumin	25-33	toll like receptor 4	Homo sapiens	98-102
17041101-7	2006	Analysis of the effects of the analogues on the expression of cancer-related genes usually affected by curcumin indicated that some induced the down-regulation of beta-catenin, Ki-ras, cyclin D1, c-Myc, and ErbB-2 at as low as one eighth the concentration at which curcumin normally has an effect.	Curcumin	103-111	KRAS proto-oncogene, GTPase	Homo sapiens	177-183
16678799-9	2006	These results suggest that TLR4 receptor complex is the molecular target of curcumin in addition to IKKbeta.	Curcumin	76-84	toll like receptor 4	Homo sapiens	27-31
16678799-10	2006	Here, we report biochemical evidence that phytochemicals (curcumin and sesquiterpene lactone) inhibit both ligand-induced and ligand-independent dimerization of TLR4.	Curcumin	58-66	toll like receptor 4	Homo sapiens	161-165
16779518-6	2006	Although aortic wall inflammation was similar between the groups, the structural integrity of medial elastin was significantly greater in curcumin-treated mice.	Curcumin	138-146	elastin	Mus musculus	101-108
16779518-8	2006	These data demonstrate for the first time that oral administration of curcumin can suppress the development of experimental AAAs, along with structural preservation of medial elastin fibers and reduced aortic wall expression of several cytokines, chemokines, and proteinases known to mediate aneurysmal degeneration.	Curcumin	70-78	elastin	Mus musculus	175-182
16354769-9	2006	Curcumin and hemin also induced nuclear Nrf2 and HO-1 effectively in wild-type mouse embryo fibroblasts (wt MEFs) and in B-Raf(-/-) MEFs but not in Nrf2(-/-) MEFs.	Curcumin	0-8	Braf transforming gene	Mus musculus	121-126
16495813-5	2006	Pretreatment with curcumin protected hepatocytes in a model of oxidative injury and this protection was mediated through HO-1.	Curcumin	18-26	heme oxygenase 1	Homo sapiens	121-125
16495813-6	2006	In a model of cold preservation injury, curcumin pretreatment resulted in elevation of HO-1 throughout the cold storage and rewarming period, and was cytoprotective against oxidative injury.	Curcumin	40-48	heme oxygenase 1	Homo sapiens	87-91
16495813-7	2006	This is the first study to demonstrate that curcumin induces HO-1 in human hepatocytes, and that the protective effects of curcumin pretreatment may have clinical potential in hepatic transplantation.	Curcumin	44-52	heme oxygenase 1	Homo sapiens	61-65
16364299-7	2006	Supplementation of curcumin in the diet dramatically reduced oxidative damage and normalized levels of BDNF, synapsin I, and CREB that had been altered after TBI.	Curcumin	19-27	cAMP responsive element binding protein 1	Rattus norvegicus	125-129
31394642-6	2006	Futhermore, curcumin induced Wee1 expression and decreased the Cdc25c, cyclin B1 and CDK1 expressions, resulting in the induction of G2/M cell cycle arrest in the colo 205 cells.	Curcumin	12-20	cell division cycle 25C	Homo sapiens	63-69
31394642-6	2006	Futhermore, curcumin induced Wee1 expression and decreased the Cdc25c, cyclin B1 and CDK1 expressions, resulting in the induction of G2/M cell cycle arrest in the colo 205 cells.	Curcumin	12-20	cyclin B1	Homo sapiens	71-80
31394642-6	2006	Futhermore, curcumin induced Wee1 expression and decreased the Cdc25c, cyclin B1 and CDK1 expressions, resulting in the induction of G2/M cell cycle arrest in the colo 205 cells.	Curcumin	12-20	cyclin dependent kinase 1	Homo sapiens	85-89
31394642-8	2006	CONCLUSION: The results indicate that curcumin promoted the gene expression of Wee1 and inhibited that of Cdc25c, CDK1 and cyclin B1.	Curcumin	38-46	cell division cycle 25C	Homo sapiens	106-112
31394642-8	2006	CONCLUSION: The results indicate that curcumin promoted the gene expression of Wee1 and inhibited that of Cdc25c, CDK1 and cyclin B1.	Curcumin	38-46	cyclin dependent kinase 1	Homo sapiens	114-118
31394642-8	2006	CONCLUSION: The results indicate that curcumin promoted the gene expression of Wee1 and inhibited that of Cdc25c, CDK1 and cyclin B1.	Curcumin	38-46	cyclin B1	Homo sapiens	123-132
17105432-4	2006	Recently, various compounds such as curcumin, nicotine and wine-related polyphenols have been reported to inhibit the formation, extension of fAbeta, as well as destabilize preformed fAbeta at pH 7.5 at 37 degrees C in vitro.	Curcumin	36-44	fumarylacetoacetate hydrolase	Mus musculus	142-148
17105432-4	2006	Recently, various compounds such as curcumin, nicotine and wine-related polyphenols have been reported to inhibit the formation, extension of fAbeta, as well as destabilize preformed fAbeta at pH 7.5 at 37 degrees C in vitro.	Curcumin	36-44	fumarylacetoacetate hydrolase	Mus musculus	183-189
17180870-9	2006	Treatment with the curry spice extract curcumin, a polyphenolic antioxidant that inhibits AP aggregation, has been strongly protective in the same mouse model.	Curcumin	39-47	LIM homeobox protein 2	Mus musculus	90-92
16409968-0	2006	[Signal transduction mechanism of curcumin in inhibiting the proliferation of bovine lens epithelial cell induced by recombinant human epidermal growth factor].	Curcumin	34-42	epidermal growth factor	Homo sapiens	135-158
16409968-1	2006	OBJECTIVE: To investigate the signal transduction mechanism of curcumin in inhibiting the proliferation of bovine lens epithelial cell (LEC) induced by recombinant human epidermal growth factor (rhEGF).	Curcumin	63-71	epidermal growth factor	Homo sapiens	170-193
15987718-0	2005	Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through reactive oxygen species-mediated upregulation of death receptor 5 (DR5).	Curcumin	0-8	TNF receptor superfamily member 10b	Homo sapiens	159-175
16243823-5	2005	Curcumin also suppressed the paclitaxel-induced expression of antiapoptotic (XIAP, IAP-1, IAP-2, Bcl-2, and Bcl-xL), proliferative (cyclooxygenase 2, c-Myc, and cyclin D1), and metastatic proteins (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1).	Curcumin	0-8	baculoviral IAP repeat containing 3	Homo sapiens	83-88
16243823-5	2005	Curcumin also suppressed the paclitaxel-induced expression of antiapoptotic (XIAP, IAP-1, IAP-2, Bcl-2, and Bcl-xL), proliferative (cyclooxygenase 2, c-Myc, and cyclin D1), and metastatic proteins (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1).	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	150-155
16342680-0	2005	[Inhibition of the expression of prostate specific antigen by curcumin].	Curcumin	62-70	kallikrein related peptidase 3	Homo sapiens	33-58
16342680-1	2005	AIM: To study the effect of curcumin on the expression of prostate specific antigen (PSA).	Curcumin	28-36	kallikrein related peptidase 3	Homo sapiens	58-89
16342680-2	2005	METHODS: AXSYM system-chemical luciferase method was used to examine the content of PSA in prostate cancer cell lines, LNCap after treated with different doses of curcumin.	Curcumin	163-171	kallikrein related peptidase 3	Homo sapiens	84-87
16342680-4	2005	Through detecting the activity of luciferase, the effect of curcumin on the promoter of PSA was studied.	Curcumin	60-68	kallikrein related peptidase 3	Homo sapiens	88-91
16342680-6	2005	RESULTS: The expression of PSA was inhibited and activity of luciferase was reduced by curcumin.	Curcumin	87-95	kallikrein related peptidase 3	Homo sapiens	27-30
16342680-8	2005	CONCLUSION: Through inhibiting AR expression, curcumin reduced the function of PSA promoter and inhibited PSA protein expression.	Curcumin	46-54	kallikrein related peptidase 3	Homo sapiens	79-82
16342680-8	2005	CONCLUSION: Through inhibiting AR expression, curcumin reduced the function of PSA promoter and inhibited PSA protein expression.	Curcumin	46-54	kallikrein related peptidase 3	Homo sapiens	106-109
15999103-6	2005	Inhibitors of glutathione synthesis (BSO), GSTs (curcumin, ethacrynic acid), and also of MRPs (MK571, sulphinpyrazone) improved the sensitising effect of GSTP1 AS RNA.	Curcumin	49-57	glutathione S-transferase pi 1	Homo sapiens	154-159
15893313-0	2005	The inhibitory mechanism of curcumin and its derivative against beta-catenin/Tcf signaling.	Curcumin	28-36	catenin beta 1	Homo sapiens	64-76
15893313-2	2005	Curcumin is known to inhibit beta-catenin/Tcf transcriptional activity in HCT116 cells but not in SW620 cells.	Curcumin	0-8	catenin beta 1	Homo sapiens	29-41
15893313-3	2005	To clarify the inhibitory effect of curcumin against beta-catenin/Tcf signaling, we tested several cancer cell lines.	Curcumin	36-44	catenin beta 1	Homo sapiens	53-65
15893313-7	2005	In the present study, we demonstrate that curcumin and its derivative are excellent inhibitors of beta-catenin/Tcf signaling in all tested cancer cell lines and the reduced beta-catenin/Tcf transcriptional activity is due to the decreased nuclear beta-catenin and Tcf-4.	Curcumin	42-50	catenin beta 1	Homo sapiens	98-110
15893313-7	2005	In the present study, we demonstrate that curcumin and its derivative are excellent inhibitors of beta-catenin/Tcf signaling in all tested cancer cell lines and the reduced beta-catenin/Tcf transcriptional activity is due to the decreased nuclear beta-catenin and Tcf-4.	Curcumin	42-50	catenin beta 1	Homo sapiens	173-185
15893313-7	2005	In the present study, we demonstrate that curcumin and its derivative are excellent inhibitors of beta-catenin/Tcf signaling in all tested cancer cell lines and the reduced beta-catenin/Tcf transcriptional activity is due to the decreased nuclear beta-catenin and Tcf-4.	Curcumin	42-50	catenin beta 1	Homo sapiens	173-185
15957838-0	2005	[Effect of curcumin on expression of human low density lipoprotein receptors in Xenopus Laevis oocytes].	Curcumin	11-19	low density lipoprotein receptor	Homo sapiens	43-76
15957838-1	2005	OBJECTIVE: To investigate the molecular mechanism of curcumin in reducing blood lipids by establishing gene expression system of human low density lipoprotein receptors (LDL-R) in Xenopus Laevis oocytes (XLO).	Curcumin	53-61	low density lipoprotein receptor	Homo sapiens	135-168
15957838-1	2005	OBJECTIVE: To investigate the molecular mechanism of curcumin in reducing blood lipids by establishing gene expression system of human low density lipoprotein receptors (LDL-R) in Xenopus Laevis oocytes (XLO).	Curcumin	53-61	low density lipoprotein receptor	Homo sapiens	170-175
16116955-4	2005	Curcumin could suppress the expression of NFkappaB p65.	Curcumin	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	51-54
16921870-3	2006	The SIEFED technique was applied to study active MPO in horse biological fluids and the effects of 2 polyphenolic molecules, curcumin and resveratrol, on MPO activity.	Curcumin	125-133	myeloperoxidase	Equus caballus	154-157
16921870-7	2006	Curcumin and resveratrol exerted a dose-dependent inhibition on MPO activity and, as they were removed before the enzymatic detection of MPO, the results suggest a direct drug-nzyme interaction or an enzyme structure modification by the drug.	Curcumin	0-8	myeloperoxidase	Equus caballus	64-67
16921870-7	2006	Curcumin and resveratrol exerted a dose-dependent inhibition on MPO activity and, as they were removed before the enzymatic detection of MPO, the results suggest a direct drug-nzyme interaction or an enzyme structure modification by the drug.	Curcumin	0-8	myeloperoxidase	Equus caballus	137-140
16685393-2	2006	The IFN-alpha-induced COX-2 expression and STAT1 activation were markedly inhibited by the addition of curcumin to the IFN-alpha-pretreated cells.	Curcumin	103-111	signal transducer and activator of transcription 1	Homo sapiens	43-48
15733976-0	2005	Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells.	Curcumin	25-33	thrombomodulin	Homo sapiens	55-69
15733976-1	2005	The objective of this study was to elucidate the effects of tumor necrosis factor-alpha (TNF-alpha) on the expression of thrombomodulin (TM) and endothelial protein C receptor (EPCR) in human endothelial cells as well as the effect of curcumin, a spice and coloring food compound, as a potential therapeutic agent.	Curcumin	235-243	thrombomodulin	Homo sapiens	121-135
15733976-1	2005	The objective of this study was to elucidate the effects of tumor necrosis factor-alpha (TNF-alpha) on the expression of thrombomodulin (TM) and endothelial protein C receptor (EPCR) in human endothelial cells as well as the effect of curcumin, a spice and coloring food compound, as a potential therapeutic agent.	Curcumin	235-243	thrombomodulin	Homo sapiens	137-139
16804017-6	2006	Furthermore, the preincubation of human keratinocytes at 43 degrees C for 1 h, followed by 24-h treatment with 3 microM curcumin, led to an increase in heat-shock protein (hsp70 and hsp90) levels by 24% and 19%, respectively, and the effect was sustained at concentrations up to 10 microM.	Curcumin	120-128	heat shock protein family A (Hsp70) member 4	Homo sapiens	172-177
15569263-6	2004	Curcumin abrogated Abeta1-40-induced expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in both peripheral blood monocytes and THP-1 cells.	Curcumin	0-8	C-C motif chemokine ligand 4	Homo sapiens	102-111
15569263-6	2004	Curcumin abrogated Abeta1-40-induced expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in both peripheral blood monocytes and THP-1 cells.	Curcumin	0-8	C-C motif chemokine ligand 2	Homo sapiens	113-118
15569263-9	2004	This involved abrogation of Egr-1 DNA binding in the promoter of CCR5 by curcumin as determined by: (i) electrophoretic mobility shift assay, (ii) transfection studies with truncated CCR5 gene promoter constructs, and (iii) chromatin immunoprecipitation analysis.	Curcumin	73-81	early growth response 1	Homo sapiens	28-33
16553789-8	2006	Pretreatment with curcumin, which has a HAT inhibitory activity specific for CBP/p300, attenuated histone modifications, IEGs expression and also the severity of status epilepticus after kainate treatment.	Curcumin	18-26	CREB binding protein	Mus musculus	77-85
15569263-11	2004	The inhibition of Egr-1 by curcumin may represent a potential therapeutic approach to ameliorate the inflammation and progression of AD.	Curcumin	27-35	early growth response 1	Homo sapiens	18-23
15807244-8	2004	When curcumin concentration reached 40 micromol/L, PI and Annexin V-FITC double positive cell (secondary apoptosis necrosis cell) became major part of cells, and the cell showed G2 phase block.	Curcumin	5-13	annexin A5	Homo sapiens	58-67
16470247-5	2006	Curcumin treatment in deltaF508-CFTR mice partially reversed the defect in ATP sensitivity.	Curcumin	0-8	cystic fibrosis transmembrane conductance regulator	Mus musculus	32-36
15252141-5	2004	Subtoxic concentrations of the curcumin-TRAIL combination induced strong apoptotic response in LNCaP cells as demonstrated by the binding of Annexin V-FITC and cleavage of procaspase-3.	Curcumin	31-39	annexin A5	Homo sapiens	141-150
14701837-5	2004	Curcumin exposure also decreases the turnover of the destabilized enhanced green fluorescence protein, a model substrate for proteasome and cellular p53 protein.	Curcumin	0-8	transformation related protein 53, pseudogene	Mus musculus	149-152
16380075-7	2006	Curcumin, an AP-1 inhibitor, dose-dependently reduced (1-25 microM) or completely abolished (50 microM) the apoptotic effect of GCDCA.	Curcumin	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-17
16106398-5	2006	Curcumin induced cell cycle arrest by reducing the expression of cyclin D1, Cdk1 and Cdc25C and apoptosis by reducing the expression of XIAP and survivin.	Curcumin	0-8	X-linked inhibitor of apoptosis	Homo sapiens	136-140
14680379-2	2003	In the present study, the interaction of the dietary polyphenol curcumin with MRP1 and MRP2 and the interplay between curcumin-dependent MRP inhibition and its glutathione-dependent metabolism were investigated using two transport model systems.	Curcumin	64-72	ATP binding cassette subfamily C member 1	Canis lupus familiaris	78-82
16584595-0	2006	[Inhibitory effect of curcumin on angiogenesis induced by brain derived neurotrophic factor from multiple myeloma cells].	Curcumin	22-30	brain derived neurotrophic factor	Homo sapiens	58-91
16584595-3	2006	The results showed that exogenous BDNF significantly induced endothelial cell tubule formation and endothelial cell migration, these two effects were inhibited by curcumin.	Curcumin	163-171	brain derived neurotrophic factor	Homo sapiens	34-38
14680379-3	2003	In isolated membrane vesicles of MRP1- and MRP2-expressing Sf9 cells, curcumin clearly inhibited both MRP1- and MRP2-mediated transport with IC(50) values of 15 and 5 microM, respectively.	Curcumin	70-78	ATP binding cassette subfamily C member 1	Canis lupus familiaris	33-37
16584595-4	2006	Furthermore, BDNF was detected in the MM cell and TrkB was detected in the endothelial cell and curcumin depressed the mRNA expression of BDNF and TrkB in the dose- and time-dependent manners.	Curcumin	96-104	brain derived neurotrophic factor	Homo sapiens	13-17
14680379-3	2003	In isolated membrane vesicles of MRP1- and MRP2-expressing Sf9 cells, curcumin clearly inhibited both MRP1- and MRP2-mediated transport with IC(50) values of 15 and 5 microM, respectively.	Curcumin	70-78	ATP binding cassette subfamily C member 1	Canis lupus familiaris	102-106
16584595-4	2006	Furthermore, BDNF was detected in the MM cell and TrkB was detected in the endothelial cell and curcumin depressed the mRNA expression of BDNF and TrkB in the dose- and time-dependent manners.	Curcumin	96-104	brain derived neurotrophic factor	Homo sapiens	138-142
14680379-4	2003	In intact monolayers of MRP1 overexpressing Madin-Darby canine kidney (MDCKII-MRP1) cells, curcumin also inhibited MRP1-mediated activity, although with a 3-fold higher IC(50) value than the one observed in the vesicle model.	Curcumin	91-99	ATP binding cassette subfamily C member 1	Canis lupus familiaris	24-28
16584595-6	2006	Curcumin interrupts the interaction between multiple myeloma cells and endothelial cells by reducing TrkB expression in endothelial cells and inhibiting BDNF production in multiple myeloma cells, eventually, resulting in inhibition of angiogenesis.	Curcumin	0-8	brain derived neurotrophic factor	Homo sapiens	153-157
14680379-4	2003	In intact monolayers of MRP1 overexpressing Madin-Darby canine kidney (MDCKII-MRP1) cells, curcumin also inhibited MRP1-mediated activity, although with a 3-fold higher IC(50) value than the one observed in the vesicle model.	Curcumin	91-99	ATP binding cassette subfamily C member 1	Canis lupus familiaris	78-82
16125882-8	2006	Inhibition of ERKs activation by AG126, JNK by SP600125, and AP-1 by curcumin could reduced the induction of cyclin D1 and CDK4.	Curcumin	69-77	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	61-65
16170359-9	2006	In addition, curcumin reduced the trans-activation activity of Egr-1 by suppressing egr-1 gene expression, which required interruption of the ERK signal pathway and reduction of the level of phosphorylation of Elk-1 and its activity.	Curcumin	13-21	ETS transcription factor ELK1	Homo sapiens	210-215
16543625-6	2006	The increased NCD on day 7 and 14 were attenuated significantly by daily treatment of curcumin solution (3000 mg/kg BW).The curcumin treatment reduced the tumor-induced over-expression of COX-2 and serum VEGF in HepG2 groups significantly (p&lt;0.001), indicating that curcumin could inhibit tumor angiogenesis.	Curcumin	86-94	vascular endothelial growth factor A	Mus musculus	204-208
16543625-6	2006	The increased NCD on day 7 and 14 were attenuated significantly by daily treatment of curcumin solution (3000 mg/kg BW).The curcumin treatment reduced the tumor-induced over-expression of COX-2 and serum VEGF in HepG2 groups significantly (p&lt;0.001), indicating that curcumin could inhibit tumor angiogenesis.	Curcumin	124-132	vascular endothelial growth factor A	Mus musculus	204-208
16543625-6	2006	The increased NCD on day 7 and 14 were attenuated significantly by daily treatment of curcumin solution (3000 mg/kg BW).The curcumin treatment reduced the tumor-induced over-expression of COX-2 and serum VEGF in HepG2 groups significantly (p&lt;0.001), indicating that curcumin could inhibit tumor angiogenesis.	Curcumin	124-132	vascular endothelial growth factor A	Mus musculus	204-208
16267275-3	2006	Of these nine, only V2R-V206D showed improved maturation and plasma membrane rescue with glycerol, dimethyl sulfoxide (DMSO), thapsigargin/curcumin, and ionomycin but not with other osmolytes or growth at 27 degrees C. This revealed that rescue is mutant specific and that this mutant is prone to rescue by multiple compounds.	Curcumin	139-147	arginine vasopressin receptor 2	Canis lupus familiaris	20-23
16267275-6	2006	Calcium measurements showed that rescue of V2R-V206D by thapsigargin, curcumin, and ionomycin was because of increased cytosolic calcium level, rather than decreased endoplasmic reticulum calcium level.	Curcumin	70-78	arginine vasopressin receptor 2	Canis lupus familiaris	43-46
17044774-7	2006	Whereas curcumin inhibited constitutive activation of both EGFR and IGF-1R, ERRP decreased activation of EGFR, ErbB-2, and ErbB-3 but had no effect on IGF-1R.	Curcumin	8-16	insulin like growth factor 1 receptor	Homo sapiens	68-74
15887245-6	2005	Curcumin inhibited the MG-induced DNA fragmentation, caspase-3 activation, cleavage of PARP, mitochondrial cytochrome c release, and JNK activation.	Curcumin	0-8	caspase 3	Mus musculus	53-62
15887245-6	2005	Curcumin inhibited the MG-induced DNA fragmentation, caspase-3 activation, cleavage of PARP, mitochondrial cytochrome c release, and JNK activation.	Curcumin	0-8	poly (ADP-ribose) polymerase family, member 1	Mus musculus	87-91
15887245-6	2005	Curcumin inhibited the MG-induced DNA fragmentation, caspase-3 activation, cleavage of PARP, mitochondrial cytochrome c release, and JNK activation.	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	133-136
16320828-0	2005	Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study.	Curcumin	0-8	integrin subunit beta 1	Homo sapiens	95-109
16320828-9	2005	The suppression of collagen type II and beta1-integrin synthesis by IL-1beta was inhibited by curcumin.	Curcumin	94-102	integrin subunit beta 1	Homo sapiens	40-54
16081677-0	2005	Curcumin suppresses interleukin 1beta-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways.	Curcumin	0-8	prostaglandin E synthase	Homo sapiens	47-84
16081677-4	2005	Interleukin-1beta-induced microsomal prostaglandin E synthase 1 (mPGES-1) and cyclooxygenase-2 were attenuated by curcumin at the protein and mRNA levels, but a more dramatic inhibition of mPGES-1 expression was observed at lower concentrations of curcumin in A549 human lung epithelial cells.	Curcumin	114-122	prostaglandin E synthase	Homo sapiens	26-63
16081677-4	2005	Interleukin-1beta-induced microsomal prostaglandin E synthase 1 (mPGES-1) and cyclooxygenase-2 were attenuated by curcumin at the protein and mRNA levels, but a more dramatic inhibition of mPGES-1 expression was observed at lower concentrations of curcumin in A549 human lung epithelial cells.	Curcumin	248-256	prostaglandin E synthase	Homo sapiens	26-63
16181535-3	2005	RESULTS: It was found for the first time that 10 micromol/L-50 micromol/L curcumin could obviously up-regulate the expression of LDL receptor in macrophages in mice, and a dose-effect relationship was demonstrated.	Curcumin	74-82	low density lipoprotein receptor	Mus musculus	129-141
16181535-4	2005	CONCLUSION: One of the lipid-lowering mechanisms of traditional Chinese medicine, Rhizoma Curcumae Longae, was completed by the effect of curcumin through the up-regulation of the expression of LDL receptor.	Curcumin	138-146	low density lipoprotein receptor	Mus musculus	194-206
15879598-6	2005	In this study we report that rat TrxR1 activity in Trx-dependent disulfide reduction was inhibited by curcumin.	Curcumin	102-110	thioredoxin reductase 1	Homo sapiens	33-38
15857825-5	2005	These CFTR agonists include 1) an uncharged NPPB analog that stimulates channel opening at submicromolar concentrations without blocking the pore and 2) curcumin, a dietary compound recently reported to augment deltaF508-CFTR function in mice by an unknown mechanism.	Curcumin	153-161	cystic fibrosis transmembrane conductance regulator	Mus musculus	6-10
15857825-5	2005	These CFTR agonists include 1) an uncharged NPPB analog that stimulates channel opening at submicromolar concentrations without blocking the pore and 2) curcumin, a dietary compound recently reported to augment deltaF508-CFTR function in mice by an unknown mechanism.	Curcumin	153-161	cystic fibrosis transmembrane conductance regulator	Mus musculus	221-225
16013440-5	2005	Curcumin-induced apoptosis is mediated through activation of caspase-3, which is specifically inhibited by the caspase-3 inhibitor, Ac-DEVD-CHO.	Curcumin	0-8	caspase 3	Mus musculus	61-70
16013440-5	2005	Curcumin-induced apoptosis is mediated through activation of caspase-3, which is specifically inhibited by the caspase-3 inhibitor, Ac-DEVD-CHO.	Curcumin	0-8	caspase 3	Mus musculus	111-120
16013440-6	2005	On the other hand, the decreased secretion of ascites by EAT cells is corroborated by reduction in VEGF secretion upon curcumin treatment.	Curcumin	119-127	vascular endothelial growth factor A	Mus musculus	99-103
16013440-8	2005	However, immunoflurescence studies of NF-kB revealed that the inhibition of nuclear translocation of NF-kB p65, a transcription factor required for VEGF gene expression, in curcumin-treated EAT cells.	Curcumin	173-181	vascular endothelial growth factor A	Mus musculus	148-152
15661804-6	2005	Curcumin-induced release of cytochrome c, Second mitochondria derived activator of caspase (Smac) and apoptosis inducing factor (AIF) was also blocked in Bax-/- cells and reintroduction of Bax, downregulation of the antiapoptotic protein Bcl-XL by antisense DNA as well as the overexpression of Smac, highly sensitized the Bax-/- cells toward curcumin-induced apoptosis.	Curcumin	0-8	apoptosis inducing factor mitochondria associated 1	Homo sapiens	102-127
15661804-6	2005	Curcumin-induced release of cytochrome c, Second mitochondria derived activator of caspase (Smac) and apoptosis inducing factor (AIF) was also blocked in Bax-/- cells and reintroduction of Bax, downregulation of the antiapoptotic protein Bcl-XL by antisense DNA as well as the overexpression of Smac, highly sensitized the Bax-/- cells toward curcumin-induced apoptosis.	Curcumin	0-8	apoptosis inducing factor mitochondria associated 1	Homo sapiens	129-132
15661804-6	2005	Curcumin-induced release of cytochrome c, Second mitochondria derived activator of caspase (Smac) and apoptosis inducing factor (AIF) was also blocked in Bax-/- cells and reintroduction of Bax, downregulation of the antiapoptotic protein Bcl-XL by antisense DNA as well as the overexpression of Smac, highly sensitized the Bax-/- cells toward curcumin-induced apoptosis.	Curcumin	343-351	apoptosis inducing factor mitochondria associated 1	Homo sapiens	129-132
15772517-7	2005	Postoperative expression of myocardial mRNA levels of interleukin 6, monocyte chemoattractant protein-1, and tumor necrosis factor-alpha, postreperfusion plasma level of troponin I, and cardiac mechanical dysfunction were significantly decreased in the curcumin groups.	Curcumin	253-261	C-C motif chemokine 2	Oryctolagus cuniculus	69-103
15615723-0	2005	Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer.	Curcumin	0-8	matrix metallopeptidase 9	Rattus norvegicus	46-79
15615723-12	2005	We conclude that antiulcer activity of curcumin is primarily attributed to MMP-9 inhibition, one of the major path-ways of ulcer healing.	Curcumin	39-47	matrix metallopeptidase 9	Rattus norvegicus	75-80
15514944-0	2005	Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin.	Curcumin	167-175	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-140
15514944-9	2005	Since a redox regulatory pathway is involved in the expression of HPV that can be modulated by an antioxidant-induced reconstitution of the AP-1 transcription complex, we have used curcumin (diferuloylmethane), an active component of the perennial herb turmeric, which is a potent antioxidant and is well-known for its antiinflammatory and anticarcinogenic activity, to modulate the transcription of AP-1 and HPV.	Curcumin	181-189	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	400-404
15514944-9	2005	Since a redox regulatory pathway is involved in the expression of HPV that can be modulated by an antioxidant-induced reconstitution of the AP-1 transcription complex, we have used curcumin (diferuloylmethane), an active component of the perennial herb turmeric, which is a potent antioxidant and is well-known for its antiinflammatory and anticarcinogenic activity, to modulate the transcription of AP-1 and HPV.	Curcumin	191-208	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-144
15514944-9	2005	Since a redox regulatory pathway is involved in the expression of HPV that can be modulated by an antioxidant-induced reconstitution of the AP-1 transcription complex, we have used curcumin (diferuloylmethane), an active component of the perennial herb turmeric, which is a potent antioxidant and is well-known for its antiinflammatory and anticarcinogenic activity, to modulate the transcription of AP-1 and HPV.	Curcumin	191-208	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	400-404
15514944-10	2005	We demonstrate for the first time that curcumin can selectively downregulate HPV18 transcription as well as the AP-1 binding activity in HeLa cells.	Curcumin	39-47	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	112-116
15514944-11	2005	Most interestingly, curcumin can reverse the expression dynamics of c-fos and fra-1 in this tumorigenic cell line, mimicking the expression pattern observed in normal controls or precancerous lesions.	Curcumin	20-28	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-73
15514944-12	2005	Observation of curcumin-mediated complete downregulation of AP-1 binding activity and reversal of c-fos/fra-1 transcription to a normal state in tumorigenic HeLa cells represents a novel mechanism that can control transcription of pathogenic HPVs during keratinocyte differentiation and progression of cervical cancer.	Curcumin	15-23	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	60-64
15514944-12	2005	Observation of curcumin-mediated complete downregulation of AP-1 binding activity and reversal of c-fos/fra-1 transcription to a normal state in tumorigenic HeLa cells represents a novel mechanism that can control transcription of pathogenic HPVs during keratinocyte differentiation and progression of cervical cancer.	Curcumin	15-23	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-103
15569263-0	2004	Curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and CCR5-mediated chemotaxis of THP-1 monocytes by modulating early growth response-1 transcription factor.	Curcumin	0-8	C-C motif chemokine receptor 5	Homo sapiens	113-117
15501252-8	2004	Topical application of curcumin, 10, 13, 21, and 6, a methoxy derivative of curcumin, showed strong inhibition of 12-O-tetradecanoyl-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in mouse skin.	Curcumin	23-31	ornithine decarboxylase, structural 1	Mus musculus	158-181
15501252-8	2004	Topical application of curcumin, 10, 13, 21, and 6, a methoxy derivative of curcumin, showed strong inhibition of 12-O-tetradecanoyl-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in mouse skin.	Curcumin	23-31	ornithine decarboxylase, structural 1	Mus musculus	183-186
15501252-8	2004	Topical application of curcumin, 10, 13, 21, and 6, a methoxy derivative of curcumin, showed strong inhibition of 12-O-tetradecanoyl-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in mouse skin.	Curcumin	76-84	ornithine decarboxylase, structural 1	Mus musculus	158-181
15501252-8	2004	Topical application of curcumin, 10, 13, 21, and 6, a methoxy derivative of curcumin, showed strong inhibition of 12-O-tetradecanoyl-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in mouse skin.	Curcumin	76-84	ornithine decarboxylase, structural 1	Mus musculus	183-186
15205359-0	2004	Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it.	Curcumin	87-95	X-ray repair cross complementing 6	Homo sapiens	32-36
15205359-5	2004	Curcumin-induced cell death and nuclear condensation was more in AsBcl-XL and AsKu70 cells that under-express Bcl-XL and Ku70, respectively, compared with the vector-transfected cells.	Curcumin	0-8	X-ray repair cross complementing 6	Homo sapiens	80-84
15205359-6	2004	Bcl-XL and Ku70 protected the cells by inhibiting the release of cytochrome c, Smac (second mitochondria derived activator of caspase) and apoptosis inducing factor (AIF), and the activation of caspases 9, 8 and 3 triggered by curcumin.	Curcumin	227-235	X-ray repair cross complementing 6	Homo sapiens	11-15
15205359-7	2004	AsBcl-XL and AsKu70 cells were more sensitive to curcumin through enhanced activation of caspases 9 and 3 and release of cytochrome c, Smac and AIF.	Curcumin	49-57	apoptosis inducing factor mitochondria associated 1	Homo sapiens	144-147
15205359-8	2004	Curcumin-induced activation of caspase 8 was blocked by Ku70 but not by Bcl-XL.	Curcumin	0-8	X-ray repair cross complementing 6	Homo sapiens	56-60
15219947-0	2004	Effect of curcumin on gelatinase A (MMP-2) activity in B16F10 melanoma cells.	Curcumin	10-18	matrix metallopeptidase 2	Mus musculus	22-34
15139522-8	2004	Phenethyl isothiocyanate, sulforaphane, curcumin, and resveratrol increased AP-1-luciferase activity dose-dependently and then decreased at higher doses in the presence or absence of TPA.	Curcumin	40-48	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-80
14604899-0	2004	Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosis.	Curcumin	115-123	heat shock protein family A (Hsp70) member 4	Homo sapiens	22-27
14604899-4	2004	The cells were protected from curcumin-induced cell death by hsp70 while cells harboring antisense hsp70 (Ashsp70) were highly sensitive to curcumin.	Curcumin	30-38	heat shock protein family A (Hsp70) member 4	Homo sapiens	61-66
14604899-4	2004	The cells were protected from curcumin-induced cell death by hsp70 while cells harboring antisense hsp70 (Ashsp70) were highly sensitive to curcumin.	Curcumin	140-148	heat shock protein family A (Hsp70) member 4	Homo sapiens	99-104
14604899-5	2004	Curcumin-induced nuclear condensation was less in hsp70 but more in Ashsp70 cells when compared with control vector-transfected cells.	Curcumin	0-8	heat shock protein family A (Hsp70) member 4	Homo sapiens	50-55
14604899-6	2004	Loss of mitochondrial transmembrane potential induced by curcumin was further accelerated by antisense hsp70 expression and hsp70 restored it partly.	Curcumin	57-65	heat shock protein family A (Hsp70) member 4	Homo sapiens	103-108
14604899-7	2004	Ashsp70 cells released more cytochrome c, AIF and Smac from mitochondria upon curcumin treatment than control cells.	Curcumin	78-86	apoptosis inducing factor mitochondria associated 1	Homo sapiens	42-45
14604899-9	2004	Activation of caspases 3 and 9 induced by curcumin was also inhibited by hsp70, whereas more activation could be seen in Ashsp70 cells, although caspase 8 activation was unaffected by changes in hsp70 expression.	Curcumin	42-50	heat shock protein family A (Hsp70) member 4	Homo sapiens	73-78
14604899-10	2004	Curcumin-induced cleavage of PARP and DFF45 was inhibited by hsp70 but enhanced in Ashsp70 cells.	Curcumin	0-8	heat shock protein family A (Hsp70) member 4	Homo sapiens	61-66
14604899-11	2004	The present study demonstrates the potential of hsp70 in protecting SW480 cells from curcumin-induced apoptosis and highlights that silencing the expression of hsp70 is an effective approach to augment curcumin-based therapy in cancers that are resistant due to hsp70 expression.	Curcumin	85-93	heat shock protein family A (Hsp70) member 4	Homo sapiens	48-53
14604899-11	2004	The present study demonstrates the potential of hsp70 in protecting SW480 cells from curcumin-induced apoptosis and highlights that silencing the expression of hsp70 is an effective approach to augment curcumin-based therapy in cancers that are resistant due to hsp70 expression.	Curcumin	202-210	heat shock protein family A (Hsp70) member 4	Homo sapiens	160-165
14604899-11	2004	The present study demonstrates the potential of hsp70 in protecting SW480 cells from curcumin-induced apoptosis and highlights that silencing the expression of hsp70 is an effective approach to augment curcumin-based therapy in cancers that are resistant due to hsp70 expression.	Curcumin	202-210	heat shock protein family A (Hsp70) member 4	Homo sapiens	160-165
14755151-8	2004	FGF-2 induced AP-1-DNA binding activity, and the c-Jun/AP-1 inhibitor curcumin attenuated the FGF-2-induced MMP-1, -3 and TIMP-1 mRNA expression.	Curcumin	70-78	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-54
14755151-8	2004	FGF-2 induced AP-1-DNA binding activity, and the c-Jun/AP-1 inhibitor curcumin attenuated the FGF-2-induced MMP-1, -3 and TIMP-1 mRNA expression.	Curcumin	70-78	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-59
14627502-8	2003	The abundance of p210bcr/abl as well as MEK-1 and c-JUN proteins were strongly down-regulated in curcumin-treated p210bcr/abl-positive K562 cells while c-JUN and MEK-1 proteins were only slightly down-regulated in p210bcr/abl-negative HL-60 cells.	Curcumin	97-105	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-55
14627502-8	2003	The abundance of p210bcr/abl as well as MEK-1 and c-JUN proteins were strongly down-regulated in curcumin-treated p210bcr/abl-positive K562 cells while c-JUN and MEK-1 proteins were only slightly down-regulated in p210bcr/abl-negative HL-60 cells.	Curcumin	97-105	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	152-157
14534529-4	2003	The amount of wee1 and c-Fos and the phosphorylation of cdc2 were decreased after treatment of the cells with an inhibitor of AP-1, curcumin.	Curcumin	132-140	WEE1 G2 checkpoint kinase	Homo sapiens	14-18
14534529-4	2003	The amount of wee1 and c-Fos and the phosphorylation of cdc2 were decreased after treatment of the cells with an inhibitor of AP-1, curcumin.	Curcumin	132-140	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	23-28
14534529-4	2003	The amount of wee1 and c-Fos and the phosphorylation of cdc2 were decreased after treatment of the cells with an inhibitor of AP-1, curcumin.	Curcumin	132-140	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	126-130
12660143-0	2003	Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth.	Curcumin	104-112	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	14-62
12660143-9	2003	It was hypothesized that curcumin might inhibit the proliferation of activated HSC by inducing PPAR-gamma gene expression and reviving PPAR-gamma activation.	Curcumin	25-33	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	95-105
12660143-9	2003	It was hypothesized that curcumin might inhibit the proliferation of activated HSC by inducing PPAR-gamma gene expression and reviving PPAR-gamma activation.	Curcumin	25-33	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	135-145
12660143-11	2003	We demonstrated, for the first time, that curcumin dramatically induced the gene expression of PPAR-gamma and activated PPAR-gamma in activated HSC.	Curcumin	42-50	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	95-105
12660143-11	2003	We demonstrated, for the first time, that curcumin dramatically induced the gene expression of PPAR-gamma and activated PPAR-gamma in activated HSC.	Curcumin	42-50	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	120-130
12660143-12	2003	Blocking its trans-activating activity by a PPAR-gamma antagonist markedly abrogated the effects of curcumin on inhibition of cell proliferation.	Curcumin	100-108	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	44-54
12770926-7	2003	4 In curcumin-pretreated mice, there was a significant reduction in the degree of both neutrophil infiltration (measured as decrease in myeloperoxidase activity) and lipid peroxidation (measured as decrease in malondialdehyde activity) in the inflamed colon as well as decreased serine protease activity.	Curcumin	5-13	myeloperoxidase	Mus musculus	136-151
12770926-7	2003	4 In curcumin-pretreated mice, there was a significant reduction in the degree of both neutrophil infiltration (measured as decrease in myeloperoxidase activity) and lipid peroxidation (measured as decrease in malondialdehyde activity) in the inflamed colon as well as decreased serine protease activity.	Curcumin	5-13	complement component 1, s subcomponent 1	Mus musculus	279-294
12628923-10	2003	Curcumin, emodin, DRB and resveratrol block CSN-associated kinases and induce degradation of c-Jun in HeLa cells.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	93-98
12628923-11	2003	Curcumin treatment results in elevated amounts of c-Jun-Ub conjugates.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-55
14657599-5	2003	Curcumin inhibited the invasion of tumor cells through Matrigel-coated filters and the production of MMP-9.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	101-106
12454848-10	2002	Consistent with these findings, CD4(+) T-cell infiltration and NF-kappaB activation in colonic mucosa were suppressed in the curcumin-treated group.	Curcumin	125-133	CD4 antigen	Mus musculus	32-35
12130649-9	2002	Specific inhibitors of ERK1/2 activation (PD98059 and U0126), as well as JNK inhibitors (curcumin and dicumarol) antagonized the inhibitory effects of TGF-beta on ALP activity and mineralization, whereas the specific inhibitor of p38 MAPK (SB203580) did not affect them.	Curcumin	89-97	mitogen-activated protein kinase 8	Mus musculus	73-76
12216086-9	2002	The investigation of expression in IL-8 receptors, CXCR1 and CXCR2, revealed that the expression of both receptors was enhanced remarkably by curcumin.	Curcumin	142-150	C-X-C motif chemokine receptor 1	Homo sapiens	51-56
12128007-5	2002	MPP(+) treatment caused the upregulation of c-Jun amino-terminal kinase (JNK) and dopaminergic neuronal death, the latter being blocked by curcumin, an inhibitor of the c-Jun/AP-1 cascade.	Curcumin	139-147	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	44-49
12128007-5	2002	MPP(+) treatment caused the upregulation of c-Jun amino-terminal kinase (JNK) and dopaminergic neuronal death, the latter being blocked by curcumin, an inhibitor of the c-Jun/AP-1 cascade.	Curcumin	139-147	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	169-174
12128007-5	2002	MPP(+) treatment caused the upregulation of c-Jun amino-terminal kinase (JNK) and dopaminergic neuronal death, the latter being blocked by curcumin, an inhibitor of the c-Jun/AP-1 cascade.	Curcumin	139-147	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	175-179
11854435-2	2002	Curcumin, a polyphenolic natural compound that possesses anti-tumor and anti-inflammatory properties, has been reported recently to induce potently HO-1 expression in vascular endothelial cells (Free Rad Biol Med 28:1303-1312, 2000).	Curcumin	0-8	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	200-203
11815407-12	2002	Curcumin was sulfated by human phenol sulfotransferase isoenzymes SULT1A1 and SULT1A3.	Curcumin	0-8	sulfotransferase family 1A member 3	Homo sapiens	78-85
11731421-6	2001	Inhibition of CSN kinase activity by 50 microM curcumin for 2 h decreases the cellular c-Jun concentration, resulting in a reduction of the VEGF production by approximately 75%.	Curcumin	47-55	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	87-92
11755008-3	2001	We used 22 month Sprague-Dawley (SD) rats to compare the effects of the conventional NSAID, ibuprofen, and curcumin for their ability to protect against amyloid beta-protein (Abeta)-induced damage.	Curcumin	107-115	amyloid beta precursor protein	Rattus norvegicus	175-180
11755008-5	2001	Dietary curcumin (2000 ppm), but not ibuprofen, suppressed oxidative damage (isoprostane levels) and synaptophysin loss.	Curcumin	8-16	synaptophysin	Rattus norvegicus	101-114
11755008-6	2001	Both ibuprofen and curcumin reduced microgliosis in cortical layers, but curcumin increased microglial labeling within and adjacent to Abeta-ir deposits.	Curcumin	73-81	amyloid beta precursor protein	Rattus norvegicus	135-140
11755008-7	2001	In a second group of middle-aged female SD rats, 500 ppm dietary curcumin prevented Abeta-infusion induced spatial memory deficits in the Morris Water Maze and post-synaptic density (PSD)-95 loss and reduced Abeta deposits.	Curcumin	65-73	amyloid beta precursor protein	Rattus norvegicus	84-89
11338405-14	2001	Curcumin, a plant pigment, dramatically inhibited both TPA- and TPA + UVA-induced expression of ODC and MT genes.	Curcumin	0-8	ornithine decarboxylase, structural 1	Mus musculus	96-99
11207308-8	2001	Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.	Curcumin	11-19	signal transducer and activator of transcription 1	Homo sapiens	95-100
11207308-8	2001	Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.	Curcumin	11-19	signal transducer and activator of transcription 1	Homo sapiens	142-147
11207308-8	2001	Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.	Curcumin	21-38	signal transducer and activator of transcription 1	Homo sapiens	95-100
11207308-8	2001	Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.	Curcumin	21-38	signal transducer and activator of transcription 1	Homo sapiens	142-147
11207308-9	2001	Curcumin also inhibited OSM-induced MMP-1, MMP-3, MMP-13, and TIMP-3 gene expression.	Curcumin	0-8	TIMP metallopeptidase inhibitor 3	Homo sapiens	62-68
11231886-0	2001	Inhibition of carcinogen induced c-Ha-ras and c-fos proto-oncogenes expression by dietary curcumin.	Curcumin	90-98	Harvey rat sarcoma virus oncogene	Mus musculus	33-41
11029517-0	2000	Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence.	Curcumin	0-8	linoleate 9S-lipoxygenase-4	Glycine max	18-30
11029517-1	2000	Many lipoxygenase inhibitors including curcumin are currently being studied for their anti-carcinogenic properties.	Curcumin	39-47	linoleate 9S-lipoxygenase-4	Glycine max	5-17
11029517-3	2000	Recently it was shown that the soybean lipoxygenase L1 catalyzed the oxygenation of curcumin and that curcumin can act as a lipoxygenase substrate.	Curcumin	84-92	linoleate 9S-lipoxygenase-4	Glycine max	39-51
11029517-3	2000	Recently it was shown that the soybean lipoxygenase L1 catalyzed the oxygenation of curcumin and that curcumin can act as a lipoxygenase substrate.	Curcumin	102-110	linoleate 9S-lipoxygenase-4	Glycine max	39-51
11029517-6	2000	Understanding how curcumin inhibits lipoxygenase may help in the development of novel anti-cancer drugs used for treatment where lipoxygenases are involved.	Curcumin	18-26	linoleate 9S-lipoxygenase-4	Glycine max	36-48
10942386-7	2000	Coexpression of dominant negative versions of kinases of the JNK pathway, such as catalytically inactive forms of MEKK1, MKK7, and JNKK, and of cytoplasmic JNK-inhibitor JIP-1, as well as treatment of cells with curcumin (which blocks JNK activation by MNNG), inhibited MNNG-induced uPA transcriptional activity.	Curcumin	212-220	mitogen-activated protein kinase 8	Mus musculus	61-64
10657978-11	2000	While hepatic tissues obtained from the DEN-treated mice showed a remarkable increase in the levels of p21(ras), PCNA and CDC2 proteins, eating a curcumin-containing diet reversed the levels to normal values.	Curcumin	146-154	proliferating cell nuclear antigen	Mus musculus	113-117
10617637-10	2000	The mRNA up-regulation of MMPs was also inhibited by curcumin, an inhibitor of transcription factor AP-1, whereas interleukin-1 receptor antagonist, an IL-1 receptor antagonist, failed to inhibit the mRNA up-regulation.	Curcumin	53-61	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	100-104
10576620-2	1999	We demonstrate here that out of three compounds, viz diferuloylmethane, p-coumaroylferuloylmethane and di-p-coumaroylmethane, present in the ethyl acetate extract of Curcuma longa, diferuloylmethane is most potent in inhibiting TNF-alpha induced expression of ICAM-1, VCAM-1 and E-selectin on human umbilical vein endothelial cells.	Curcumin	181-198	intercellular adhesion molecule 1	Homo sapiens	260-266
10477620-5	1999	Curcumin inhibited IL-1 beta-mediated ICAM-1 and IL-8 gene expression in IEC-6, HT-29, and Caco-2 cells.	Curcumin	0-8	intercellular adhesion molecule 1	Rattus norvegicus	38-44
9674701-6	1998	In transfection assays, curcumin moderately suppressed MEKK1-induced JNK activation; however, it effectively blocked JNK activation caused by co-transfection of TAK1, GCK, or HPK1.	Curcumin	24-32	glucokinase	Homo sapiens	167-170
9674701-6	1998	In transfection assays, curcumin moderately suppressed MEKK1-induced JNK activation; however, it effectively blocked JNK activation caused by co-transfection of TAK1, GCK, or HPK1.	Curcumin	24-32	mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens	175-179
9674701-8	1998	Although curcumin suppressed TAK1 and GCK activities at high concentrations, this inhibition cannot fully account for the JNK inhibition by curcumin in vivo.	Curcumin	9-17	glucokinase	Homo sapiens	38-41
10780880-7	1998	Finally, curcumin was tested for its ability to inhibit phorbol ester-stimulated vascular endothelial growth factor (VEGF) mRNA production.	Curcumin	9-17	vascular endothelial growth factor A	Mus musculus	81-115
10780880-7	1998	Finally, curcumin was tested for its ability to inhibit phorbol ester-stimulated vascular endothelial growth factor (VEGF) mRNA production.	Curcumin	9-17	vascular endothelial growth factor A	Mus musculus	117-121
9586949-4	1998	Pretreatment of EC for 1 hr with curcumin completely blocked their adhesion to monocytes, as well as the cell surface expression of ICAM-1, VCAM-1, and ELAM-1 in EC.	Curcumin	33-41	intercellular adhesion molecule 1	Homo sapiens	132-138
9600699-6	1998	Linoleic acid, curcumin and butylated hydroxytoluene (BHT) also significantly inhibited DBP DNA adduction (26-46%) while N-acetylcysteine (NAC) had no effect.	Curcumin	15-23	D-box binding PAR bZIP transcription factor	Rattus norvegicus	88-91
9651124-2	1998	In this study curcumin was tested for its potential ability to interact in vitro with hepatic P-glycoprotein (Pgp), in a model system represented by primary cultures of rat hepatocytes, in which spontaneous overexpression of multidrug resistance (mdr) genes occurs.	Curcumin	14-22	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	94-108
9651124-2	1998	In this study curcumin was tested for its potential ability to interact in vitro with hepatic P-glycoprotein (Pgp), in a model system represented by primary cultures of rat hepatocytes, in which spontaneous overexpression of multidrug resistance (mdr) genes occurs.	Curcumin	14-22	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	110-113
9651124-3	1998	In both freshly-plated hepatocytes, containing low levels of Pgp, and 72 hour-cultured hepatocytes, containing high levels of Pgp, the Rhodamine-123 (R-123) efflux, which represents a specific functional test for Pgp-mediated transport, was inhibited by curcumin in a dose-dependent manner.	Curcumin	254-262	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	126-129
9651124-3	1998	In both freshly-plated hepatocytes, containing low levels of Pgp, and 72 hour-cultured hepatocytes, containing high levels of Pgp, the Rhodamine-123 (R-123) efflux, which represents a specific functional test for Pgp-mediated transport, was inhibited by curcumin in a dose-dependent manner.	Curcumin	254-262	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	126-129
9651124-6	1998	The resistance to curcumin, progressively acquired by cells during culture, was significantly reduced by high concentrations of dexamethasone (DEX) or dimethyl-sulfoxide (DMSO), culture conditions known to inhibit the spontaneous overexpression of Pgp.	Curcumin	18-26	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	248-251
9651124-7	1998	In addition, in a concentration-dependent manner, verapamil reverted curcumin resistance in Pgp overexpressing hepatocytes.	Curcumin	69-77	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	92-95
9651124-8	1998	In photoaffinity labeling studies, curcumin competed with azidopine for binding to Pgp, suggesting a direct interaction with glycoprotein.	Curcumin	35-43	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	83-86
9651124-9	1998	These results suggest that curcumin is able to modulate in vitro both expression and function of hepatic Pgp and support the hypothesis that curcumin, a chemopreventive phytochemical, could reveal itself also as a compound endowed with chemosensitizing properties on mdr phenotype.	Curcumin	27-35	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	105-108
9651124-9	1998	These results suggest that curcumin is able to modulate in vitro both expression and function of hepatic Pgp and support the hypothesis that curcumin, a chemopreventive phytochemical, could reveal itself also as a compound endowed with chemosensitizing properties on mdr phenotype.	Curcumin	141-149	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	105-108
9437186-7	1997	The present data show that curcumin prevented the activation of c-Rel/p65, which is essential for TF gene activation in endothelial cells, by impairing the proteolytic degradation inhibitor protein, I kappa B alpha.	Curcumin	27-35	REL proto-oncogene, NF-kB subunit	Homo sapiens	64-69
14680379-4	2003	In intact monolayers of MRP1 overexpressing Madin-Darby canine kidney (MDCKII-MRP1) cells, curcumin also inhibited MRP1-mediated activity, although with a 3-fold higher IC(50) value than the one observed in the vesicle model.	Curcumin	91-99	ATP binding cassette subfamily C member 1	Canis lupus familiaris	78-82
14680379-9	2003	From dose-response curves with Sf9 membrane vesicles, glutathionylcurcumin conjugates appeared to be less potent inhibitors of MRP1 and MRP2 than their parent compound curcumin.	Curcumin	66-74	ATP binding cassette subfamily C member 1	Canis lupus familiaris	127-131
14728887-13	2003	CONCLUSION: Curcumin could inhibit the human mesangial cell proliferation and alter the extracellular matrix turnover, meanwhile it could down-regulate the IL-1 beta and MCP-1 mRNA expression induced by LPS, which may be valuable in decreasing the progression of glomerulosclerosis.	Curcumin	12-20	C-C motif chemokine ligand 2	Homo sapiens	170-175
9388508-5	1997	Downregulation of c-Jun/AP-1 using a transdominant negative mutant of c-jun, an antisense c-jun, or a pharmacologic inhibitor curcumin inhibited the H2O2-initiated apoptosis.	Curcumin	126-134	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-23
9388508-5	1997	Downregulation of c-Jun/AP-1 using a transdominant negative mutant of c-jun, an antisense c-jun, or a pharmacologic inhibitor curcumin inhibited the H2O2-initiated apoptosis.	Curcumin	126-134	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	24-28
14511674-6	2003	Co-treatment with isoflavones, curcumin and tetrahydrocurcumin, increased [3H]EGCG accumulation significantly in MDCKII/MRP1 and HT-29 cells.	Curcumin	31-39	ATP binding cassette subfamily C member 1	Canis lupus familiaris	120-124
9168063-4	1997	Curcumin attenuates the levels of MCP-1/JE and IP-10 mRNA expression by all of these stimulatory agents.	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	34-39
9134658-7	1997	Curcumin inhibited TNF alpha induced I kappa B alpha degradation and the nuclear import of NF-kappa B.	Curcumin	0-8	NFKB inhibitor alpha	Bos taurus	37-52
9439980-1	1997	We have previously demonstrated that anti-inflammatory and antioxidant compound curcumin (diferuloyl-methane) inhibits the expression of monocyte chemoattractant protein-1 (MCP-1/JE) in bone marrow stromal cells by suppressing the transcriptional activity of the MCP-1/JE gene.	Curcumin	80-88	chemokine (C-C motif) ligand 2	Mus musculus	137-171
9439980-1	1997	We have previously demonstrated that anti-inflammatory and antioxidant compound curcumin (diferuloyl-methane) inhibits the expression of monocyte chemoattractant protein-1 (MCP-1/JE) in bone marrow stromal cells by suppressing the transcriptional activity of the MCP-1/JE gene.	Curcumin	80-88	chemokine (C-C motif) ligand 2	Mus musculus	173-178
9439980-1	1997	We have previously demonstrated that anti-inflammatory and antioxidant compound curcumin (diferuloyl-methane) inhibits the expression of monocyte chemoattractant protein-1 (MCP-1/JE) in bone marrow stromal cells by suppressing the transcriptional activity of the MCP-1/JE gene.	Curcumin	80-88	chemokine (C-C motif) ligand 2	Mus musculus	263-268
9439980-1	1997	We have previously demonstrated that anti-inflammatory and antioxidant compound curcumin (diferuloyl-methane) inhibits the expression of monocyte chemoattractant protein-1 (MCP-1/JE) in bone marrow stromal cells by suppressing the transcriptional activity of the MCP-1/JE gene.	Curcumin	90-108	chemokine (C-C motif) ligand 2	Mus musculus	137-171
9439980-1	1997	We have previously demonstrated that anti-inflammatory and antioxidant compound curcumin (diferuloyl-methane) inhibits the expression of monocyte chemoattractant protein-1 (MCP-1/JE) in bone marrow stromal cells by suppressing the transcriptional activity of the MCP-1/JE gene.	Curcumin	90-108	chemokine (C-C motif) ligand 2	Mus musculus	173-178
9439980-1	1997	We have previously demonstrated that anti-inflammatory and antioxidant compound curcumin (diferuloyl-methane) inhibits the expression of monocyte chemoattractant protein-1 (MCP-1/JE) in bone marrow stromal cells by suppressing the transcriptional activity of the MCP-1/JE gene.	Curcumin	90-108	chemokine (C-C motif) ligand 2	Mus musculus	263-268
9439980-5	1997	These data suggest that inhibition of MCP-1/JE transcription by curcumin involves blocking of AP-1 and NF-kB activation by IL1 alpha or TNF-alpha.	Curcumin	64-72	chemokine (C-C motif) ligand 2	Mus musculus	38-43
14577663-5	2003	Curcumin was more active than nicardipine in inhibiting LA and DHGLA conversion: 20 microM curcumin, alone or with simvastatin, totally inhibited delta6 and delta5 desaturation steps; 10 microM nicardipine only partially inhibited the enzymes, being more active on delta5 desaturase.	Curcumin	0-8	fatty acid desaturase 1	Homo sapiens	265-282
8989916-0	1996	Induction of HSP70 gene expression by modulation of Ca(+2) ion and cellular p53 protein by curcumin in colorectal carcinoma cells.	Curcumin	91-99	heat shock protein family A (Hsp70) member 4	Homo sapiens	13-18
8989916-5	1996	The reduction of p53 gene expression was accompanied by the induction of HSP70 gene expression in the curcumin-treated cells.	Curcumin	102-110	heat shock protein family A (Hsp70) member 4	Homo sapiens	73-78
8989916-6	1996	These findings suggest that curcumin may induce the expression of the HSP70 gene through the initial depletion of intracellular Ca(+2), followed by the suppression of p53 gene function in the target cells.	Curcumin	28-36	heat shock protein family A (Hsp70) member 4	Homo sapiens	70-75
8663179-9	1996	Because curcumin (20 microM), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta-stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase-dependent signal transduction pathways.	Curcumin	8-16	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	46-51
14577663-5	2003	Curcumin was more active than nicardipine in inhibiting LA and DHGLA conversion: 20 microM curcumin, alone or with simvastatin, totally inhibited delta6 and delta5 desaturation steps; 10 microM nicardipine only partially inhibited the enzymes, being more active on delta5 desaturase.	Curcumin	91-99	fatty acid desaturase 1	Homo sapiens	265-282
8663179-9	1996	Because curcumin (20 microM), an inhibitor of c-jun/AP-1 and protein kinases, also blocked IL-1beta-stimulated IL-8 gene expression implicating c-JUN/AP-1 and protein phosphorylation in the induction of IL-8 gene expression by IL-1beta, we conclude that the regulation of IL-8 mRNA by IL-1beta is mediated via protein kinase-dependent signal transduction pathways.	Curcumin	8-16	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	144-149
12781211-5	2003	The results also demonstrated that gene expression (NAT1 mRNA) in human lung A549 tumor cells was inhibited and decreased by curcumin.	Curcumin	125-133	N-acetyltransferase 1	Homo sapiens	52-56
8769830-10	1996	Transfection of mesangial cells with a c-jun antisense cDNA and treatment with a pharmacological inhibitor of c-Jun/ AP-1, curcumin, revealed that the induction of c-Jun/AP-1 is essential for the expression of MMP-9 by IL-1 beta.	Curcumin	123-131	matrix metallopeptidase 9	Rattus norvegicus	210-215
7602115-6	1995	TGF-beta 1 stimulated transcriptionally the JE/MCP-1 gene expression, and this stimulation was inhibited significantly by curcumin.	Curcumin	122-130	chemokine (C-C motif) ligand 2	Mus musculus	47-52
7602115-7	1995	Curcumin-induced inhibition of the JE/MCP-1 gene product was also evidenced by both an assay involving immunoprecipitation with antiserum specific for JE/MCP-1 and an assay for monocyte chemotaxis.	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	38-43
7602115-7	1995	Curcumin-induced inhibition of the JE/MCP-1 gene product was also evidenced by both an assay involving immunoprecipitation with antiserum specific for JE/MCP-1 and an assay for monocyte chemotaxis.	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	154-159
8538195-15	1995	Curcumin enhances glutathione content and glutathione-S-transferase activity in liver; and it inhibits lipid peroxidation and arachidonic acid metabolism in mouse skin, protein kinase C activity in TPA-treated NIH 3T3 cells, chemically induced ODC and tyrosine protein kinase activities in rat colon, and 8-hydroxyguanosine formation in mouse fibroblasts.	Curcumin	0-8	ornithine decarboxylase, structural 1	Mus musculus	244-247
12778080-0	2003	Age-related difference in susceptibility of Apc(Min/+) mice towards the chemopreventive efficacy of dietary aspirin and curcumin.	Curcumin	120-128	APC, WNT signaling pathway regulator	Mus musculus	44-47
7955078-0	1994	Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis.	Curcumin	10-18	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-111
7955078-0	1994	Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis.	Curcumin	10-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-121
7955078-6	1994	The increased expression of c-Jun and morphological changes observed at 24 h after treatment of JB6 cells with TPA (10 ng/ml) was inhibited by curcumin (10 nmol/ml).	Curcumin	143-151	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-33
12778080-1	2003	The nonsteroidal anti-inflammatory drug aspirin and the spice curcumin retard adenoma formation when administered long-term to Apc(Min/+) mice, a model of human familial adenomatous polyposis coli.	Curcumin	62-70	APC, WNT signaling pathway regulator	Mus musculus	127-130
7955078-11	1994	Topical application of 10 mumol curcumin together with 5 nmol TPA once a day for 5 days strongly inhibited TPA-induced epidermal hyperplasia and c-Jun and c-Fos expression.	Curcumin	32-40	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	145-150
7955078-11	1994	Topical application of 10 mumol curcumin together with 5 nmol TPA once a day for 5 days strongly inhibited TPA-induced epidermal hyperplasia and c-Jun and c-Fos expression.	Curcumin	32-40	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	155-160
12778080-4	2003	Here the hypothesis was tested that dietary aspirin (0.05%) or curcumin (0.2%) prevent or delay adenoma formation in offsprings when administered to Apc(Min/+) mothers and up to the end of weaning, but not afterwards.	Curcumin	63-71	APC, WNT signaling pathway regulator	Mus musculus	149-152
12678405-5	2003	The binding to fibronectin, vitronectin, and collagen IV decreased by over 50% in 24 hours, and by 100% after 48 hours of curcumin treatment, it persisted at this level even after 15 days of cultivating cells in curcumin-free medium.	Curcumin	122-130	fibronectin 1	Mus musculus	15-26
12678405-5	2003	The binding to fibronectin, vitronectin, and collagen IV decreased by over 50% in 24 hours, and by 100% after 48 hours of curcumin treatment, it persisted at this level even after 15 days of cultivating cells in curcumin-free medium.	Curcumin	212-220	fibronectin 1	Mus musculus	15-26
12678405-7	2003	In addition, curcumin treatment inhibited pp125 focal adhesion kinase (FAK), tyrosine phosphorylation of a 120 kD protein, and collagenase activity.	Curcumin	13-21	PTK2 protein tyrosine kinase 2	Mus musculus	71-74
12973926-0	2003	The effect of curcumin on mismatch repair (MMR) proteins hMSH2 and hMLH1 after ultraviolet (UV) irradiation on HL-60 cells.	Curcumin	14-22	mutL homolog 1	Homo sapiens	67-72
8055654-0	1994	Inhibitory effect of curcumin on xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NIH3T3 cells.	Curcumin	21-29	xanthine dehydrogenase	Mus musculus	33-63
8055654-2	1994	Simultaneous administration of 2 and 10 microM curcumin with 100 ng/ml PMA inhibits PMA-induced increases in XO activity measured 30 min later by 22.7% and 36.5%, respectively.	Curcumin	47-55	xanthine dehydrogenase	Mus musculus	109-111
8055654-3	1994	The PMA-induced conversion of xanthine dehydrogenase (XD) to XO is reduced by curcumin to the basal level noted in untreated cells.	Curcumin	78-86	xanthine dehydrogenase	Mus musculus	30-52
12558151-6	2003	Diferuloylmethane blocks the induced expression of ICAM-1 and VCAM-1 in liver and lungs.	Curcumin	0-17	vascular cell adhesion molecule 1	Mus musculus	62-68
8055654-3	1994	The PMA-induced conversion of xanthine dehydrogenase (XD) to XO is reduced by curcumin to the basal level noted in untreated cells.	Curcumin	78-86	xanthine dehydrogenase	Mus musculus	61-63
8055654-4	1994	Activity of XO is remarkably inhibited by curcumin in vitro, but not by its structurally related compounds caffeic acid, chlorogenic acid and ferulic acid.	Curcumin	42-50	xanthine dehydrogenase	Mus musculus	12-14
12105223-7	2002	Curcumin, but not PD98059 or SB203580, inhibited IL-1 beta-mediated suppression of nuclear RXR:RAR binding activity, which correlated with inhibition of JNK phosphorylation and phospho-JNK-mediated phosphorylation of RXR.	Curcumin	0-8	retinoic acid receptor alpha	Homo sapiens	95-98
12055272-7	2002	In vitro treatment of activated T cells with curcumin inhibited IL-12-induced tyrosine phosphorylation of Janus kinase 2, tyrosine kinase 2, and STAT3 and STAT4 transcription factors.	Curcumin	45-53	Janus kinase 2	Mus musculus	106-120
11981161-10	2002	Curcumin, an inhibitor of JNK pathway, attenuated the cell death.	Curcumin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	26-29
8435870-0	1993	Inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced increase in ornithine decarboxylase mRNA in mouse epidermis.	Curcumin	21-29	ornithine decarboxylase, structural 1	Mus musculus	90-113
12171541-10	2002	Curcumin inhibits the initiation of carcinogenesis by inhibiting the cytochrome P-450 enzyme activity and increasing the levels of glutathione-S-transferase.	Curcumin	0-8	glutathione S-transferase kappa 1	Homo sapiens	131-156
12674762-4	2002	It was found that when HL-60 cells were treated with 25 mumol/L curcumin for 24 h, the expression level of Mcl-1 was down-regulated, but that of Bax and Bak up-regulated time-dependently.	Curcumin	64-72	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	107-112
12674762-5	2002	There was significant difference in the expression level of Mcl-1, Bax and Bak between the curcumin-treated groups and control group (P &lt; 0.05-0.01).	Curcumin	91-99	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	60-65
12674762-6	2002	At the same time, curcumin had no effect on progress of cell cycle in primaty acute myelogenous leukemia at newly diagnosis, but could increase the peak of Sub-G1 (P &lt; 0.05), and down-regulate the expression of Mcl-1 and up-regulate the expression of Bax and Bak with the difference being statistically significant.	Curcumin	18-26	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	214-219
11716543-7	2001	To further support our hypothesis that curcumin induces activation of a death receptor pathway, we show that curcumin induces Fas receptor aggregation in a FasL-independent manner and that low-temperature incubation, previously shown to inhibit receptor aggregation, prevented curcumin-induced cell death.	Curcumin	109-117	Fas ligand	Homo sapiens	156-160
11716543-7	2001	To further support our hypothesis that curcumin induces activation of a death receptor pathway, we show that curcumin induces Fas receptor aggregation in a FasL-independent manner and that low-temperature incubation, previously shown to inhibit receptor aggregation, prevented curcumin-induced cell death.	Curcumin	109-117	Fas ligand	Homo sapiens	156-160
11716543-8	2001	Moreover, we demonstrate that expression of dominant negative FADD significantly inhibited curcumin-induced cell death.	Curcumin	91-99	Fas associated via death domain	Homo sapiens	62-66
11544338-5	2001	The results showed that curcumin levels &gt; or =30 microM profoundly inhibited isopentenyl pyrophosphate-induced release of the chemokines macrophage inflammatory protein-1alpha and -1beta and RANTES.	Curcumin	24-32	C-C motif chemokine ligand 3	Homo sapiens	140-189
11322764-1	2001	We conducted the following experiments to determine whether curcumin, an antioxidant compound extracted from the spice tumeric, inhibits cell death induced by Shiga toxin (Stx) 1 and 2 in HK-2 cells, a human proximal tubule cell line.	Curcumin	60-68	syntaxin 1A	Homo sapiens	159-184
11322764-8	2001	Addition of 20 microM curcumin decreased the extent of apoptosis and necrosis to 2.9 +/- 2.0 and 3.8 +/- 0.2%, respectively in the presence of Stx1 and to 3.0 +/- 2.1 and 3.9 +/- 0.3%, respectively, for Stx2 (P &lt; 0.01).	Curcumin	22-30	syntaxin 1A	Homo sapiens	143-147
11322764-10	2001	The protective effect of curcumin against Stx1 and Stx2-induced injury to HK-2 was not related to its antioxidant properties.	Curcumin	25-33	syntaxin 1A	Homo sapiens	42-46
11053056-6	2000	Furthermore, treatment with either PD098059, SB203580, or the JNK-AP-1 inhibitor curcumin diminished the expression of MCP-1 and stromelysin.	Curcumin	81-89	C-C motif chemokine ligand 2	Homo sapiens	119-124
11038236-3	2000	Immunoblotting analysis showed that CCM strongly inhibited DEN-mediated the increased expression of oncogenic p21(ras) and p53 proteins in liver tissues of rats.	Curcumin	36-39	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	123-126
10988260-9	2000	This increase of c-fos mRNA expression was blocked by PD98059; in addition, curcumin, a blocker of the transcriptional factor AP-1, canceled the effect of Ang II on the collagen I gene.	Curcumin	76-84	FBJ osteosarcoma oncogene	Mus musculus	17-22
10996298-5	2000	The presence of GSTP1-1 significantly accelerated the initial rate of GSH-mediated consumption of curcumin in 10 mM potassium phosphate, pH 7.0, and 1 mM GSH.	Curcumin	98-106	glutathione S-transferase pi 1	Homo sapiens	16-23
10996298-6	2000	GSTP1-1 kinetics determined using HPLC indicated substrate inhibition (apparent K(m) for curcumin of 25+/-11 microM, and apparent K(i) for curcumin of 8+/-3 microM).	Curcumin	89-97	glutathione S-transferase pi 1	Homo sapiens	0-7
10996298-6	2000	GSTP1-1 kinetics determined using HPLC indicated substrate inhibition (apparent K(m) for curcumin of 25+/-11 microM, and apparent K(i) for curcumin of 8+/-3 microM).	Curcumin	139-147	glutathione S-transferase pi 1	Homo sapiens	0-7
10996298-7	2000	GSTP1-1 was also shown to catalyze the reverse reaction leading to the formation of curcumin from GSH adducts of FMK and FAL.	Curcumin	84-92	glutathione S-transferase pi 1	Homo sapiens	0-7
10747850-0	2000	L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis.	Curcumin	56-64	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	44-48
10783313-10	2000	These data place the plant phenolics CAPE and curcumin among a growing list of anti-inflammatory agents that suppress Apc-associated intestinal carcinogenesis.	Curcumin	46-54	APC, WNT signaling pathway regulator	Mus musculus	118-121
10674404-0	2000	Suppression of transcription factor Egr-1 by curcumin.	Curcumin	45-53	early growth response 1	Homo sapiens	36-41
10674404-2	2000	In the present study, we investigated the effect of curcumin, a natural plant phenolic compound known to exhibit anticarcinogenic, antioxidant, and antiinflammatory properties, on Egr-1 expression in endothelial cells and fibroblasts.	Curcumin	52-60	early growth response 1	Homo sapiens	180-185
10674404-3	2000	Gel mobility shift assays showed that pretreatment of endothelial cells and fibroblasts with curcumin suppressed phorbol 12-myristate 13-acetate and serum-induced Egr-1 binding activity to the consensus Egr-1 binding site and also to the Egr-1 binding site present in the promoter of tissue factor gene.	Curcumin	93-101	early growth response 1	Homo sapiens	163-168
10674404-3	2000	Gel mobility shift assays showed that pretreatment of endothelial cells and fibroblasts with curcumin suppressed phorbol 12-myristate 13-acetate and serum-induced Egr-1 binding activity to the consensus Egr-1 binding site and also to the Egr-1 binding site present in the promoter of tissue factor gene.	Curcumin	93-101	early growth response 1	Homo sapiens	203-208
10674404-3	2000	Gel mobility shift assays showed that pretreatment of endothelial cells and fibroblasts with curcumin suppressed phorbol 12-myristate 13-acetate and serum-induced Egr-1 binding activity to the consensus Egr-1 binding site and also to the Egr-1 binding site present in the promoter of tissue factor gene.	Curcumin	93-101	early growth response 1	Homo sapiens	203-208
10674404-3	2000	Gel mobility shift assays showed that pretreatment of endothelial cells and fibroblasts with curcumin suppressed phorbol 12-myristate 13-acetate and serum-induced Egr-1 binding activity to the consensus Egr-1 binding site and also to the Egr-1 binding site present in the promoter of tissue factor gene.	Curcumin	93-101	coagulation factor III, tissue factor	Homo sapiens	284-297
10674404-4	2000	Western blot analysis revealed that curcumin inhibited phorbol 12-myristate 13-acetate-induced de novo synthesis of Egr-1 protein in endothelial cells.	Curcumin	36-44	early growth response 1	Homo sapiens	116-121
10674404-5	2000	Suppression of Egr-1 protein expression in curcumin-treated cells stemmed from the suppression of Egr-1 mRNA.	Curcumin	43-51	early growth response 1	Homo sapiens	15-20
10674404-5	2000	Suppression of Egr-1 protein expression in curcumin-treated cells stemmed from the suppression of Egr-1 mRNA.	Curcumin	43-51	early growth response 1	Homo sapiens	98-103
10674404-6	2000	Northern blot analysis showed that curcumin inhibited serum and phorbol 12-myristate 13-acetate induced expression of tissue factor and urokinase-type plasminogen activator receptor mRNA in fibroblasts.	Curcumin	35-43	coagulation factor III, tissue factor	Homo sapiens	118-131
10674404-7	2000	Cumulatively, the data show that curcumin suppresses the induction of transcription factor Egr-1 and thereby modulates the expression of Egr-1-regulated genes in endothelial cells and fibroblasts.	Curcumin	33-41	early growth response 1	Homo sapiens	91-96
10965519-0	2000	Genistein and curcumin block TGF-beta 1-induced u-PA expression and migratory and invasive phenotype in mouse epidermal keratinocytes.	Curcumin	14-22	plasminogen activator, urokinase	Mus musculus	48-52
10965519-2	2000	In this report, we analyzed the biological behavior of two naturally occurring inhibitors of protein tyrosine kinases, genistein and curcumin, that could abrogate the enhancement of u-PA levels induced by TGF-beta 1 in transformed keratinocytes.	Curcumin	133-141	plasminogen activator, urokinase	Mus musculus	182-186
10456330-0	1999	Curcumin mediated apoptosis in AK-5 tumor cells involves the production of reactive oxygen intermediates.	Curcumin	0-8	adenylate kinase isoenzyme 5	Rattus norvegicus	31-35
10456330-3	1999	Curcumin was shown to be responsible for the inhibition of AK-5 tumor (a rat histiocytoma) growth by inducing apoptosis in AK-5 tumor cells via caspase activation.	Curcumin	0-8	adenylate kinase isoenzyme 5	Rattus norvegicus	59-63
10456330-3	1999	Curcumin was shown to be responsible for the inhibition of AK-5 tumor (a rat histiocytoma) growth by inducing apoptosis in AK-5 tumor cells via caspase activation.	Curcumin	0-8	adenylate kinase isoenzyme 5	Rattus norvegicus	123-127
10456330-6	1999	This study suggests redox signalling and caspase activation as the mechanisms responsible for the induction of curcumin mediated apoptosis in AK-5 tumor cells.	Curcumin	111-119	adenylate kinase isoenzyme 5	Rattus norvegicus	142-146
10445426-6	1999	Curcumin treatment caused a reduction in the expression of Ki67, PCNA, and p53 mRNAs in breast cancer cells.	Curcumin	0-8	proliferating cell nuclear antigen	Homo sapiens	65-69
8435870-3	1993	Topical administration of 1, 3 or 10 mumol curcumin together with 5 nmol TPA inhibited by 66, 81 and 91% respectively TPA-induced increases in epidermal ODC enzyme activity measured 5 h later.	Curcumin	43-51	ornithine decarboxylase, structural 1	Mus musculus	153-156
9744529-5	1998	of 2% curcumin in the diet to female A/J mice for 14 days, which has been shown to cause a significant inhibition in BaP-induced forestomach tumorigenesis, resulted in a modest but statistically significant reduction in hepatic ethoxyresorufin O-deethylase (EROD) activity, a reaction preferentially catalyzed by CYP1A1.	Curcumin	6-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	313-319
33761621-2	2021	C66 is a curcumin derivative that exerts anti-inflammatory effects by inhibiting the JNK pathway and prevents diabetic nephropathy.	Curcumin	9-17	mitogen-activated protein kinase 8	Mus musculus	85-88
33761621-9	2021	In all, we demonstrated that curcumin analogue C66 attenuates obesity-induced renal injury by inhibiting chronic inflammation and apoptosis via targeting NF-kappaB and JNK.	Curcumin	29-37	mitogen-activated protein kinase 8	Mus musculus	168-171
33000266-13	2020	By contrast, the expression of migration-associated proteins, including MMP-9, NF-kappaB and claudin-3, was downregulated with increasing curcumin concentrations.	Curcumin	138-146	matrix metallopeptidase 9	Homo sapiens	72-77
33000266-13	2020	By contrast, the expression of migration-associated proteins, including MMP-9, NF-kappaB and claudin-3, was downregulated with increasing curcumin concentrations.	Curcumin	138-146	claudin 3	Homo sapiens	93-102
26628981-0	2015	Curcumin protects against cerebral ischemia-reperfusion injury by activating JAK2/STAT3 signaling pathway in rats.	Curcumin	0-8	Janus kinase 2	Rattus norvegicus	77-81
9744529-8	1998	Even though the levels of various hepatic GST isoenzymes were significantly increased upon curcumin feeding, maximum induction was noticed for the pi class isoenzyme (mGSTP1-1), which among murine hepatic GSTs is highly efficient in the detoxification of (+)-anti-BaPDE.	Curcumin	91-99	glutathione S-transferase, pi 1	Mus musculus	167-175
9667742-3	1998	Of the beta-diketone compounds initially screened for their capacity to induce quinone-reductase (QR) activity in wild-type Hepa1c1c7 cells and a mutant subclone, curcumin (diferuloylmethane) and dibenzoylmethane were most effective.	Curcumin	163-171	crystallin, zeta	Mus musculus	79-96
25132338-0	2014	Curcumin attenuates cardiac fibrosis in spontaneously hypertensive rats through PPAR-gamma activation.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	80-90
34592340-0	2022	Curcumin inhibits the invasion and metastasis of triple negative breast cancer via Hedgehog/Gli1 signaling pathway.	Curcumin	0-8	GLI family zinc finger 1	Homo sapiens	92-96
34592340-6	2022	AIM OF THE STUDY: To explore the mechanism of curcumin and Glioma-associated oncogene homolod-1 (Gli1) on invasion and metastasis of triple negative breast cancer (TNBC) cells through the Hedgehog (Hh)/Gli signaling pathway.	Curcumin	46-54	GLI family zinc finger 1	Homo sapiens	97-101
34592340-6	2022	AIM OF THE STUDY: To explore the mechanism of curcumin and Glioma-associated oncogene homolod-1 (Gli1) on invasion and metastasis of triple negative breast cancer (TNBC) cells through the Hedgehog (Hh)/Gli signaling pathway.	Curcumin	46-54	GLI family zinc finger 1	Homo sapiens	202-205
34592340-15	2022	Furthermore, curcumin reduced the invasion and migration abilities in stable Gli1-overexpressing MDA-MB-231 cell.	Curcumin	13-21	GLI family zinc finger 1	Homo sapiens	77-81
9667742-3	1998	Of the beta-diketone compounds initially screened for their capacity to induce quinone-reductase (QR) activity in wild-type Hepa1c1c7 cells and a mutant subclone, curcumin (diferuloylmethane) and dibenzoylmethane were most effective.	Curcumin	163-171	crystallin, zeta	Mus musculus	98-100
9667742-3	1998	Of the beta-diketone compounds initially screened for their capacity to induce quinone-reductase (QR) activity in wild-type Hepa1c1c7 cells and a mutant subclone, curcumin (diferuloylmethane) and dibenzoylmethane were most effective.	Curcumin	173-190	crystallin, zeta	Mus musculus	98-100
9530200-8	1998	Inhibition of the AP-1 transcription factor with curcumin decreased the cytokine induction of HO-1 mRNA, suggesting the involvement of this transcription factor in cytokine signaling of HO-1.	Curcumin	49-57	heme oxygenase 1	Homo sapiens	94-98
34592340-17	2022	Observation of laser confocal microscope showed that Gli1 were expressed mainly in nucleus in MDA-MB-231 adherent cells and completely in nucleus in BCSCs, which was significantly reduced in the nucleus and cytoplasm after curcumin treatment.	Curcumin	223-231	GLI family zinc finger 1	Homo sapiens	53-57
34592340-19	2022	CONCLUSIONS: Curcumin can inhibit the proliferation and metastasis of TNBC cells, EMT and characteristics of BCSC by Hedgehog/Gli1 pathway.	Curcumin	13-21	GLI family zinc finger 1	Homo sapiens	126-130
34902518-5	2022	Curcumin promoted the myelination of SCs (Schwann cells) by increasing the expression of peripheral myelin protein 22 (PMP22), fibrin, S100, and proliferating cell nuclear antige (PCNA).	Curcumin	0-8	peripheral myelin protein 22	Rattus norvegicus	89-117
34902518-5	2022	Curcumin promoted the myelination of SCs (Schwann cells) by increasing the expression of peripheral myelin protein 22 (PMP22), fibrin, S100, and proliferating cell nuclear antige (PCNA).	Curcumin	0-8	peripheral myelin protein 22	Rattus norvegicus	119-124
34902518-5	2022	Curcumin promoted the myelination of SCs (Schwann cells) by increasing the expression of peripheral myelin protein 22 (PMP22), fibrin, S100, and proliferating cell nuclear antige (PCNA).	Curcumin	0-8	proliferating cell nuclear antigen	Rattus norvegicus	180-184
34719837-0	2022	Inhibition of boldenone-induced aggression in rats by curcumin: Targeting TLR4/MyD88/TRAF-6/NF-kappaB pathway.	Curcumin	54-62	TNF receptor associated factor 6	Rattus norvegicus	85-91
9530200-8	1998	Inhibition of the AP-1 transcription factor with curcumin decreased the cytokine induction of HO-1 mRNA, suggesting the involvement of this transcription factor in cytokine signaling of HO-1.	Curcumin	49-57	heme oxygenase 1	Homo sapiens	186-190
34719837-10	2022	Interestingly, curcumin mitigated boldenone-induced neurobehavioral disturbances in rats, normalized the oxidant/antioxidant balance, and suppressed TLR4/MyD88/TRAF-6/NF-kappaB pathway and its downstream proinflammatory signaling molecules TNF-alpha and IL-1beta.	Curcumin	15-23	TNF receptor associated factor 6	Rattus norvegicus	160-166
9463521-2	1997	When GSTP1-1 was incubated with a 50-fold molar excess of the aldehydes acrolein (ACR) and 4-hydroxy-2-nonenal (HNE) and the ketones curcumin (CUR) and ethacrynic acid (EA) at 22 degrees C, all of them inactivated GSTP1-1.	Curcumin	133-141	glutathione S-transferase pi 1	Homo sapiens	5-12
8534266-8	1996	In liver cytosol from rats treated with phenobarbital (PB), curcumin inhibited GST activity in a mixed-type manner with a Ki of 5.75 microM and Ki of 12.5 microM.	Curcumin	60-68	hematopoietic prostaglandin D synthase	Rattus norvegicus	79-82
7553596-0	1995	A labile hyperphosphorylated c-Fos protein is induced in mouse fibroblast cells treated with a combination of phorbol ester and anti-tumor promoter curcumin.	Curcumin	148-156	FBJ osteosarcoma oncogene	Mus musculus	29-34
7553596-3	1995	We therefore hypothesized that c-Fos may be one of the targets of curcumin action.	Curcumin	66-74	FBJ osteosarcoma oncogene	Mus musculus	31-36
7553596-4	1995	In the present study, the effects of curcumin on TPA-induced c-fos mRNA and protein levels were determined by RNA hybridization and western blot analysis, respectively.	Curcumin	37-45	FBJ osteosarcoma oncogene	Mus musculus	61-66
7553596-5	1995	Curcumin decreases the TPA-induced nuclear abundance of c-Fos protein in spite of the slight super-induction of c-fos mRNA.	Curcumin	0-8	FBJ osteosarcoma oncogene	Mus musculus	56-61
7553596-7	1995	However, the c-Fos protein seems susceptible to rapid degradation by 45 min if NIH 3T3 cells were treated with TPA in the presence of curcumin.	Curcumin	134-142	FBJ osteosarcoma oncogene	Mus musculus	13-18
7553596-8	1995	The curcumin-induced hyperphosphorylated forms of c-Fos proteins are significantly more unstable; they entirely disappeared within 40 min after incubation at 37 degrees C. These findings prompted us to suggest that the decrease of c-Fos protein could account for the repressed in vitro DNA binding probably by reducing the Jun/Fos complex formation.	Curcumin	4-12	FBJ osteosarcoma oncogene	Mus musculus	50-55
7553596-8	1995	The curcumin-induced hyperphosphorylated forms of c-Fos proteins are significantly more unstable; they entirely disappeared within 40 min after incubation at 37 degrees C. These findings prompted us to suggest that the decrease of c-Fos protein could account for the repressed in vitro DNA binding probably by reducing the Jun/Fos complex formation.	Curcumin	4-12	FBJ osteosarcoma oncogene	Mus musculus	231-236
7553596-8	1995	The curcumin-induced hyperphosphorylated forms of c-Fos proteins are significantly more unstable; they entirely disappeared within 40 min after incubation at 37 degrees C. These findings prompted us to suggest that the decrease of c-Fos protein could account for the repressed in vitro DNA binding probably by reducing the Jun/Fos complex formation.	Curcumin	4-12	FBJ osteosarcoma oncogene	Mus musculus	52-55
33812170-10	2021	The results showed that curcumin significantly inhibited pERK signaling and downregulated L1 expression in SW620 cells.	Curcumin	24-32	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	57-61
33817806-0	2022	Identification of curcumin as a potential alpha-glucosidase and dipeptidyl-peptidase 4 inhibitor: Molecular docking study, in vitro and in vivo biological evaluation.	Curcumin	18-26	sucrase-isomaltase	Homo sapiens	42-59
33817806-0	2022	Identification of curcumin as a potential alpha-glucosidase and dipeptidyl-peptidase 4 inhibitor: Molecular docking study, in vitro and in vivo biological evaluation.	Curcumin	18-26	dipeptidyl peptidase 4	Homo sapiens	64-86
33817806-3	2022	The results indicated that curcumin is an inhibitor of both alpha-glucosidase and dipeptidyl-peptidase 4 (DPP-4), which are important for glycemic control.	Curcumin	27-35	sucrase-isomaltase	Homo sapiens	60-77
33817806-3	2022	The results indicated that curcumin is an inhibitor of both alpha-glucosidase and dipeptidyl-peptidase 4 (DPP-4), which are important for glycemic control.	Curcumin	27-35	dipeptidyl peptidase 4	Homo sapiens	82-104
33817806-3	2022	The results indicated that curcumin is an inhibitor of both alpha-glucosidase and dipeptidyl-peptidase 4 (DPP-4), which are important for glycemic control.	Curcumin	27-35	dipeptidyl peptidase 4	Homo sapiens	106-111
33817806-7	2022	Curcumin also upregulated the expression of genes (e.g., glucagon-like peptide 1) related to DPP-4 activity in the small intestine.	Curcumin	0-8	dipeptidyl peptidase 4	Homo sapiens	93-98
33809462-8	2021	This review discusses curcumin"s anticancer mechanism through modulation of Rb, p53, MAPK, P13K/Akt, JAK/STAT, Shh, and NF-kappaB pathways, which are commonly involved and dysregulated in preclinical and clinical GBM models.	Curcumin	22-30	sonic hedgehog signaling molecule	Homo sapiens	111-114
33589661-9	2021	This was further confirmed by western blot analysis that showed overexpression of caspase 9 indicating curcumin role in apoptosis.	Curcumin	103-111	caspase 9	Homo sapiens	82-91
33234350-0	2021	Curcumin represses mTORC1 signaling in Caco-2 cells by a two-sided mechanism involving the loss of IRS-1 and activation of AMPK.	Curcumin	0-8	insulin receptor substrate 1	Homo sapiens	99-104
34634654-10	2022	Protein expressions of MMP-9, HDAC 1, H3acK9 and NF-kB p65 were modulated in intranasal curcumin and SoB pretreatment groups.	Curcumin	88-96	histone deacetylase 1	Mus musculus	30-36
34634654-11	2022	CONCLUSION: This is the first report where intranasal curcumin inhibited asthma severity via affecting HDAC 1 (H3acK9) leading to NF-kB suppression in mouse model of allergic asthma.	Curcumin	54-62	histone deacetylase 1	Mus musculus	103-109
34950248-0	2021	Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1alpha/FNDC5/BDNF Pathway.	Curcumin	0-8	fibronectin type III domain containing 5	Rattus norvegicus	108-113
34957997-6	2021	Furthermore, curcumin treatment suppressed the expression of DNA methylation-related enzymes, including DNMT1, DNMT3A, and DNMT3B, in NSCLC cells.	Curcumin	13-21	DNA methyltransferase 3 alpha	Homo sapiens	111-117
34957997-6	2021	Furthermore, curcumin treatment suppressed the expression of DNA methylation-related enzymes, including DNMT1, DNMT3A, and DNMT3B, in NSCLC cells.	Curcumin	13-21	DNA methyltransferase 3 beta	Homo sapiens	123-129
34105152-1	2021	Retraction: "Curcumin ameliorates atherosclerosis through upregulation of miR-126," by Yezhou Li, Leilei Tian, Dajun Sun, Dexin Yin, J Cell Physiol.	Curcumin	13-21	microRNA 126	Homo sapiens	74-81
34837026-0	2021	Curcumin derivative ST09 modulates the miR-199a-5p/DDR1 axis and regulates proliferation and migration in ovarian cancer cells.	Curcumin	0-8	discoidin domain receptor tyrosine kinase 1	Homo sapiens	51-55
34749565-7	2022	CONCLUSIONS: Ustekinumab inhibits the inflammatory cytokines IL-12P40 and IL-23, while curcumin has antioxidant effects (increasing SOD, GPx, and CAT levels) with anti-inflammatory effects (decreasing the proinflammatory cytokine TNF-alpha and IL-17).	Curcumin	87-95	interleukin 17A	Rattus norvegicus	244-249
34887767-1	2021	The therapeutic use of curcumin and chemically modified curcumin (CMC) for suppressing melanogenesis and tyrosinase activity have been recognized.	Curcumin	23-31	tyrosinase	Cavia porcellus	105-115
34887767-1	2021	The therapeutic use of curcumin and chemically modified curcumin (CMC) for suppressing melanogenesis and tyrosinase activity have been recognized.	Curcumin	56-64	tyrosinase	Cavia porcellus	105-115
34828017-6	2021	The expression levels of apoptotic genes or proteins in either pro-apoptosis (CASP3 and FAS) or anti-apoptosis (BCL2, BCL2L1, and CFLAR) were significantly manipulated by the effects of either quercetin or curcumin.	Curcumin	206-214	BCL2 apoptosis regulator	Bos taurus	112-116
34828017-6	2021	The expression levels of apoptotic genes or proteins in either pro-apoptosis (CASP3 and FAS) or anti-apoptosis (BCL2, BCL2L1, and CFLAR) were significantly manipulated by the effects of either quercetin or curcumin.	Curcumin	206-214	BCL2 like 1	Bos taurus	118-124
34833991-12	2021	Finally, the pro-inflammatory cytokines (IL-1beta, IL-6, and IL-8) released by PBMCs triggered by SARS-CoV-2 were decreased after treatment with curcumin.	Curcumin	145-153	interleukin 1 alpha	Homo sapiens	41-49
34758851-15	2021	Co-IP assay results showed that curcumin promoted the interaction of Nrf2 with the GSK-3beta/beta-TrCP axis and ubiquitin.	Curcumin	32-40	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	93-102
34487706-0	2021	LncRNA H19 abrogates the protective effects of curcumin on rat carotid balloon injury via activating Wnt/beta-catenin signaling pathway.	Curcumin	47-55	catenin beta 1	Rattus norvegicus	105-117
34688163-4	2022	Besides, we probed the association of naturally occurring polyphenols: EGCG (a proven anti TTR aggregation agent as positive control), resveratrol and curcumin in mitigating the pathogenic repercussions of mutant TTR.	Curcumin	151-159	transthyretin	Homo sapiens	213-216
34931590-7	2022	In addition, curcumin inhibited the expression of Tfh-related transcription factors BCL-6, p-STAT3, Foxp1, Roquin-1, Roquin-2 and SAP, and significantly upregulated the protein levels of Blimp-1 and STAT3 in colon tissue.	Curcumin	13-21	B cell leukemia/lymphoma 6	Mus musculus	84-89
34931590-7	2022	In addition, curcumin inhibited the expression of Tfh-related transcription factors BCL-6, p-STAT3, Foxp1, Roquin-1, Roquin-2 and SAP, and significantly upregulated the protein levels of Blimp-1 and STAT3 in colon tissue.	Curcumin	13-21	forkhead box P1	Mus musculus	100-105
34955862-11	2021	Transcriptomic analyses revealed that curcumin either alone, or combined with insulin, inhibited the AGE-RAGE signaling pathway and the extracellular matrix (ECM)-receptor interaction in the diabetic retina.	Curcumin	38-46	renin binding protein	Rattus norvegicus	101-104
34487706-6	2021	Furthermore, the inhibition of the expression of H19 by curcumin resulted in the inactivation of the Wnt/beta-catenin signaling.	Curcumin	56-64	catenin beta 1	Rattus norvegicus	105-117
34487706-7	2021	Overall, we show that curcumin suppresses intimal hyperplasia via the H19/Wnt/beta-catenin pathway, implying that H19 is a critical molecule in the suppression of intimal hyperplasia after balloon injury by curcumin.	Curcumin	22-30	catenin beta 1	Rattus norvegicus	78-90
34487706-7	2021	Overall, we show that curcumin suppresses intimal hyperplasia via the H19/Wnt/beta-catenin pathway, implying that H19 is a critical molecule in the suppression of intimal hyperplasia after balloon injury by curcumin.	Curcumin	207-215	catenin beta 1	Rattus norvegicus	78-90
34628227-13	2021	Moreover, AMPARs appear to have a potential influence on cancer development, and the curcumin-based compounds might provide insight into the nature of this relationship.	Curcumin	85-93	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	10-16
34687286-5	2021	Curcumin, an effective natural anti-inflammatory compound, is encapsulated into CXCR4-CMVs through physical entrapment (CXCR4/Cur-CMVs), with the membrane integrity of CXCR4/Cur-CMVs being well-preserved.	Curcumin	0-8	chemokine (C-X-C motif) receptor 4	Mus musculus	80-85
34687286-5	2021	Curcumin, an effective natural anti-inflammatory compound, is encapsulated into CXCR4-CMVs through physical entrapment (CXCR4/Cur-CMVs), with the membrane integrity of CXCR4/Cur-CMVs being well-preserved.	Curcumin	0-8	chemokine (C-X-C motif) receptor 4	Mus musculus	120-125
34944613-0	2021	Cadmium-Induced Kidney Injury in Mice Is Counteracted by a Flavonoid-Rich Extract of Bergamot Juice, Alone or in Association with Curcumin and Resveratrol, via the Enhancement of Different Defense Mechanisms.	Curcumin	130-138	cathepsin D	Mus musculus	0-7
34825004-13	2021	It was concluded that curcumin administered in combination with Glu-GNPs and X-ray irradiation could reduce the protein expression of VEGF, HSP90, HIF-1alpha, and MMP9 in tumor tissue when compared with the model group.	Curcumin	22-30	vascular endothelial growth factor A	Mus musculus	134-138
34272803-4	2021	Curcumin treatment (200 mg/kg) not only decreased the deposition of arsenic in liver and kidney, but also relieved the hepatic and nephritic biochemical indexes (Glutamic oxaloacetic transaminase (AST), Alanine aminotransferase (ALT), albumin, and creatinine) altered by arsenic at doses of 10 and 25 mg/L via drinking water.	Curcumin	0-8	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	197-200
34272803-4	2021	Curcumin treatment (200 mg/kg) not only decreased the deposition of arsenic in liver and kidney, but also relieved the hepatic and nephritic biochemical indexes (Glutamic oxaloacetic transaminase (AST), Alanine aminotransferase (ALT), albumin, and creatinine) altered by arsenic at doses of 10 and 25 mg/L via drinking water.	Curcumin	0-8	glutamic pyruvic transaminase, soluble	Mus musculus	203-227
34272803-4	2021	Curcumin treatment (200 mg/kg) not only decreased the deposition of arsenic in liver and kidney, but also relieved the hepatic and nephritic biochemical indexes (Glutamic oxaloacetic transaminase (AST), Alanine aminotransferase (ALT), albumin, and creatinine) altered by arsenic at doses of 10 and 25 mg/L via drinking water.	Curcumin	0-8	glutamic pyruvic transaminase, soluble	Mus musculus	229-232
34510720-6	2021	Moreover, curcumin supplementation reduced expression of other key pro-inflammatory genes, such as NF-kappaB p65 subunit (p65), Stat1, Tlr4, and Il6, in WAT (p<0.05).	Curcumin	10-18	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	99-126
34592487-6	2021	Flow cytometry were used to analyze the effects of Curcumin on the expression of programmed cell death protein 1 (PD-1) and T-cell immunoglobulin and mucin-domain3 (TIM-3) on CD4, CD8 and Treg.	Curcumin	51-59	hepatitis A virus cellular receptor 2	Homo sapiens	165-170
34592487-6	2021	Flow cytometry were used to analyze the effects of Curcumin on the expression of programmed cell death protein 1 (PD-1) and T-cell immunoglobulin and mucin-domain3 (TIM-3) on CD4, CD8 and Treg.	Curcumin	51-59	CD4 molecule	Sus scrofa	175-178
34802538-0	2021	The ameliorative effect of curcumin on hepatic CYP1A1 and CYP1A2 genes dysregulation and hepatorenal damage induced by fenitrothion oral intoxication in male rats.	Curcumin	27-35	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	47-53
34829791-7	2021	Treatment with curcumin and radiation significantly reduced cell viability in both U87 and T98 cell lines.	Curcumin	15-23	small nucleolar RNA, C/D box 87	Homo sapiens	83-86
34541720-8	2021	Moreover, gene expressions of TBX21 (p = .02) and FOXP3 (p = .005) genes were significantly decreased and increased between nano-curcumin and placebo groups on day 7, respectively.	Curcumin	129-137	T-box transcription factor 21	Homo sapiens	30-35
34679721-7	2021	Compared with curcumin, compound 18 better reduced lipid peroxidation levels, malondialdehyde (MDA), in SH-SY5Y cells under oxidative stress pressure and recovered intracellular glutathione synthetase (GSH) levels.	Curcumin	14-22	glutathione synthetase	Homo sapiens	178-200
34829581-0	2021	Curcumin Ameliorates the Cd-Induced Anxiety-like Behavior in Mice by Regulating Oxidative Stress and Neuro-Inflammatory Proteins in the Prefrontal Cortex Region of the Brain.	Curcumin	0-8	cathepsin D	Mus musculus	25-27
34829581-4	2021	In our previous research paper, we have reported the ameliorative effect of curcumin in Cd-induced hippocampal neurodegeneration.	Curcumin	76-84	cathepsin D	Mus musculus	88-90
34659400-7	2021	Curcumin administration significantly upregulated ZO-1 and claudin-1 protein levels and reduced Caco-2 cell apoptosis.	Curcumin	0-8	claudin 1	Homo sapiens	59-68
34679721-7	2021	Compared with curcumin, compound 18 better reduced lipid peroxidation levels, malondialdehyde (MDA), in SH-SY5Y cells under oxidative stress pressure and recovered intracellular glutathione synthetase (GSH) levels.	Curcumin	14-22	glutathione synthetase	Homo sapiens	202-205
34519485-0	2021	Curcumin Complex Analogues as Near-Infrared Fluorescent Probes for Monitoring all Abeta Species in the Early Alzheimer"s Disease Model.	Curcumin	0-8	amyloid beta (A4) precursor protein	Mus musculus	82-87
34659400-9	2021	Furthermore, curcumin administration greatly blocked the protein kinase-like endoplasmic reticulum kinase- (PERK-) eukaryotic translation initiation factor 2alpha- (eIF2alpha-) activating transcription factor 4- (ATF4-) CHOP signaling pathway.	Curcumin	13-21	eukaryotic translation initiation factor 2A	Homo sapiens	165-174
34659400-9	2021	Furthermore, curcumin administration greatly blocked the protein kinase-like endoplasmic reticulum kinase- (PERK-) eukaryotic translation initiation factor 2alpha- (eIF2alpha-) activating transcription factor 4- (ATF4-) CHOP signaling pathway.	Curcumin	13-21	activating transcription factor 4	Homo sapiens	177-210
34659400-9	2021	Furthermore, curcumin administration greatly blocked the protein kinase-like endoplasmic reticulum kinase- (PERK-) eukaryotic translation initiation factor 2alpha- (eIF2alpha-) activating transcription factor 4- (ATF4-) CHOP signaling pathway.	Curcumin	13-21	activating transcription factor 4	Homo sapiens	213-217
34630845-6	2021	Furthermore, curcumin significantly reduced the number of gasdermin D+ (GSDMD+) Iba1+ and caspase-1+Iba1+ microglia/macrophage 21 days after stroke.	Curcumin	13-21	gasdermin D	Mus musculus	58-69
34630845-6	2021	Furthermore, curcumin significantly reduced the number of gasdermin D+ (GSDMD+) Iba1+ and caspase-1+Iba1+ microglia/macrophage 21 days after stroke.	Curcumin	13-21	gasdermin D	Mus musculus	72-77
34519485-6	2021	Here, we describe a near-infrared fluorescent chemical probe, termed AD-1, developed through complexation of curcumin analogues with a stabilizer, which has good photophysical properties and shows high binding to all Abeta species in solution tests.	Curcumin	109-117	amyloid beta (A4) precursor protein	Mus musculus	217-222
34323243-5	2021	In the present study, curcumin, a natural polyphenolic compound, was found to re-induce cell differentiation and increase the expression of thyroid-specific transcription factors, TTF-1, TTF-2 and transcriptional factor paired box 8 (PAX8), and iodide-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase (TPO) and sodium iodide symporter (NIS) in dedifferentiated thyroid cancer cell lines, BCPAP and KTC-1.	Curcumin	22-30	transcription termination factor 2	Homo sapiens	187-192
34323243-5	2021	In the present study, curcumin, a natural polyphenolic compound, was found to re-induce cell differentiation and increase the expression of thyroid-specific transcription factors, TTF-1, TTF-2 and transcriptional factor paired box 8 (PAX8), and iodide-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase (TPO) and sodium iodide symporter (NIS) in dedifferentiated thyroid cancer cell lines, BCPAP and KTC-1.	Curcumin	22-30	thyroid stimulating hormone receptor	Homo sapiens	285-321
34282279-0	2021	Curcumin attenuates Adriamycin-resistance of acute myeloid leukemia by inhibiting the lncRNA HOTAIR/miR-20a-5p/WT1 axis.	Curcumin	0-8	HOX transcript antisense RNA	Homo sapiens	93-99
34323243-5	2021	In the present study, curcumin, a natural polyphenolic compound, was found to re-induce cell differentiation and increase the expression of thyroid-specific transcription factors, TTF-1, TTF-2 and transcriptional factor paired box 8 (PAX8), and iodide-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase (TPO) and sodium iodide symporter (NIS) in dedifferentiated thyroid cancer cell lines, BCPAP and KTC-1.	Curcumin	22-30	thyroid stimulating hormone receptor	Homo sapiens	323-327
34323243-5	2021	In the present study, curcumin, a natural polyphenolic compound, was found to re-induce cell differentiation and increase the expression of thyroid-specific transcription factors, TTF-1, TTF-2 and transcriptional factor paired box 8 (PAX8), and iodide-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase (TPO) and sodium iodide symporter (NIS) in dedifferentiated thyroid cancer cell lines, BCPAP and KTC-1.	Curcumin	22-30	thyroid peroxidase	Homo sapiens	350-353
34539332-9	2021	Moreover, in primary cultured rat dorsal root ganglion (DRG) neurons, curcumin significantly up-regulated the expression of proopiomelanocortin (Pomc) and promoted the release of beta-endorphin and enkephalin.	Curcumin	70-78	proopiomelanocortin	Rattus norvegicus	124-143
34539332-9	2021	Moreover, in primary cultured rat dorsal root ganglion (DRG) neurons, curcumin significantly up-regulated the expression of proopiomelanocortin (Pomc) and promoted the release of beta-endorphin and enkephalin.	Curcumin	70-78	proopiomelanocortin	Rattus norvegicus	145-149
34282279-3	2021	This study aimed to investigate the mechanism by which curcumin affects the resistance of AML to Adriamycin by regulating HOX transcript antisense RNA (HOTAIR) expression.	Curcumin	55-63	HOX transcript antisense RNA	Homo sapiens	122-150
34282279-3	2021	This study aimed to investigate the mechanism by which curcumin affects the resistance of AML to Adriamycin by regulating HOX transcript antisense RNA (HOTAIR) expression.	Curcumin	55-63	HOX transcript antisense RNA	Homo sapiens	152-158
34282279-7	2021	The results showed that curcumin suppressed the resistance to Adriamycin, inhibited the expression of HOTAIR and WT1, and promoted the expression of miR-20a-5p in human acute leukemia cells (HL-60) or Adriamycin-resistant HL-60 cells (HL-60/ADR).	Curcumin	24-32	HOX transcript antisense RNA	Homo sapiens	102-108
34282279-9	2021	Overexpression of HOTAIR reversed the regulatory effect of curcumin on apoptosis and migration and restored the effect of curcumin on inducing the expression of cleaved caspase3, Bax, and P27.	Curcumin	59-67	HOX transcript antisense RNA	Homo sapiens	18-24
34282279-9	2021	Overexpression of HOTAIR reversed the regulatory effect of curcumin on apoptosis and migration and restored the effect of curcumin on inducing the expression of cleaved caspase3, Bax, and P27.	Curcumin	122-130	HOX transcript antisense RNA	Homo sapiens	18-24
34159801-4	2021	OBJECTIVES: Investigate the effects of nebulized curcumin, a natural PPARg agonist, to prevent IUGR-related abnormal lung development.	Curcumin	49-57	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	69-74
34282279-10	2021	In addition, HOTAIR upregulated WT1 expression by targeting miR-20a-5p, and inhibition of miR-20a-5p reversed the regulation of Adriamycin resistance by curcumin in AML cells.	Curcumin	153-161	HOX transcript antisense RNA	Homo sapiens	13-19
34159801-10	2021	Immunohistochemistry for FABP4, a major regulator of PPARg pathway showed a decreased FABP4+ alveolar cell density in LPD-exposed animals treated by curcumin.	Curcumin	149-157	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	53-58
34159801-10	2021	Immunohistochemistry for FABP4, a major regulator of PPARg pathway showed a decreased FABP4+ alveolar cell density in LPD-exposed animals treated by curcumin.	Curcumin	149-157	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	118-121
34282279-11	2021	Finally, curcumin inhibited Adriamycin resistance by suppressing the HOTAIR/miR-20a-5p/WT1 pathway in vivo.	Curcumin	9-17	HOX transcript antisense RNA	Homo sapiens	69-75
34533799-0	2021	Mechanism of curcumin against myocardial ischaemia-reperfusion injury based on the P13K/Akt/mTOR signalling pathway.	Curcumin	13-21	mechanistic target of rapamycin kinase	Rattus norvegicus	92-96
34282279-12	2021	In short, curcumin suppressed the proliferation and migration, blocked the cell cycle progression of AML cells, and sensitized AML cells to Adriamycin by regulating the HOTAIR/miR-20a-5p/WT1 axis.	Curcumin	10-18	HOX transcript antisense RNA	Homo sapiens	169-175
34533799-1	2021	OBJECTIVE: To investigate the pharmacodynamic mechanism of curcumin against myocardial ischaemia-reperfusion injury by regulating the phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT)/rapamycin target protein (mTOR) signalling pathway.	Curcumin	59-67	mechanistic target of rapamycin kinase	Rattus norvegicus	220-224
34533799-7	2021	Curcumin can also down-regulate the expression of Bax and up-regulate the protein levels of Bcl2, p-mTOR and p-AKT (p < 0.05 or p < 0.01).	Curcumin	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	100-104
34390063-5	2021	Experimental and clinical trial evidence supports that some natural products such as curcumin, resveratrol, and quercetin have potential effects on IL-1beta suppression.	Curcumin	85-93	interleukin 1 alpha	Homo sapiens	148-156
34533799-8	2021	CONCLUSIONS: This study shows that curcumin has a significant protective effect on myocardial ischaemia-reperfusion, and its mechanism may be related to the activation of PI3K/AKT/mTOR signalling pathway and inhibition of inflammation, apoptosis and oxidative stress.	Curcumin	35-43	mechanistic target of rapamycin kinase	Rattus norvegicus	180-184
34408780-6	2021	Furthermore, we found that curcumin inhibited tumor growth and HGF-induced EMT in mice subjected to subcutaneous xenotransplantation.	Curcumin	27-35	hepatocyte growth factor	Mus musculus	63-66
34355287-5	2021	METHODS: The effect of curcumin and BDMC-A on transcription factors (NF-kappaB, p65, c-Jun, c-Fos, STAT3, 5, PPAR-gamma, beta-catenin, COX-2, MMP-9, VEGF, TIMP-2) involved in signal transduction cascade, invasion, and angiogenesis in Hep-2 cells were quantified using Western blotting and RT-PCR technique.	Curcumin	23-31	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	85-90
34517264-0	2021	Combination of curcumin with N-n-butyl haloperidol iodide inhibits hepatocellular carcinoma malignant proliferation by downregulating enhancer of zeste homolog 2 (EZH2) - lncRNA H19 to silence Wnt/beta-catenin signaling.	Curcumin	15-23	H19 imprinted maternally expressed transcript	Homo sapiens	178-181
34146894-3	2021	Furthermore, the results showed that curcumin inhibited the expression of FASN, one of the key enzymes of fatty acid synthesis pathway, thereby, causing the reduction of the production of LDs upon infection.	Curcumin	37-45	fatty acid synthase	Homo sapiens	74-78
34517264-0	2021	Combination of curcumin with N-n-butyl haloperidol iodide inhibits hepatocellular carcinoma malignant proliferation by downregulating enhancer of zeste homolog 2 (EZH2) - lncRNA H19 to silence Wnt/beta-catenin signaling.	Curcumin	15-23	catenin beta 1	Homo sapiens	197-209
34146894-4	2021	To this end, we detected transcription factor 6 (ATF6), the key factor of regulating lipid metabolism along with other related molecules (CHOP and GPR78) and found that curcumin significantly impaired the gene synthesis of ATF6, while CSFV infection promoted ATF6 expression.	Curcumin	169-177	G protein-coupled receptor 78	Homo sapiens	147-152
34198046-0	2021	Comparative protein profiling reveals the inhibitory role of curcumin on IL-17A mediated minichromosome maintenance (MCM) proteins as novel putative markers for acute lung injury in vivo.	Curcumin	61-69	minichromosome maintenance complex component 2	Mus musculus	117-120
34198046-7	2021	Several trends were identified from the proteomic subset which revealed that IL-17A induces expressions of proteins like MCM2, MCM3, and MCM6 along with other proteins involved in DR. Interestingly, curcumin was found in suppressing the expression levels of these proteins.	Curcumin	199-207	minichromosome maintenance complex component 2	Mus musculus	121-125
34336653-5	2021	We authenticated the pivotal role of thymidylate synthase (TS) in regulating the 5-FU-curcumin synergism using the TNBC pre-clinical model.	Curcumin	86-94	thymidylate synthase	Mus musculus	37-57
34198046-7	2021	Several trends were identified from the proteomic subset which revealed that IL-17A induces expressions of proteins like MCM2, MCM3, and MCM6 along with other proteins involved in DR. Interestingly, curcumin was found in suppressing the expression levels of these proteins.	Curcumin	199-207	minichromosome maintenance complex component 6	Mus musculus	137-141
34198046-10	2021	Apart from this, the present study also reports the unique contribution of curcumin in suppressing the mRNA levels of other MCMs like MCM4, MCM5, and MCM7 as well as of ORC1 and ORC2.	Curcumin	75-83	minichromosome maintenance complex component 7	Mus musculus	150-154
34462629-5	2021	And flow cytometry analysis indicated that curcumin suppressed M1 (CD45+Gr-1-CD11b+iNOS+ cells) but enhanced M2 macrophage (CD45+Gr-1-CD11b+Arg+ cells) expansion in the myocardium of MI mice during the first 7 days post-MI.	Curcumin	43-51	protein tyrosine phosphatase, receptor type, C	Mus musculus	67-71
34462629-5	2021	And flow cytometry analysis indicated that curcumin suppressed M1 (CD45+Gr-1-CD11b+iNOS+ cells) but enhanced M2 macrophage (CD45+Gr-1-CD11b+Arg+ cells) expansion in the myocardium of MI mice during the first 7 days post-MI.	Curcumin	43-51	protein tyrosine phosphatase, receptor type, C	Mus musculus	124-128
34443492-6	2021	Curcumin and resveratrol elicited beneficial effects on fast- and slow-twitch limb muscle phenotypes in cachectic mice through sirtuin-1 activation, attenuation of atrophy signaling pathways, and proteolysis in cancer cachectic mice.	Curcumin	0-8	sirtuin 1	Mus musculus	127-136
34139933-0	2021	Curcumin restrains hepatocellular carcinoma progression depending on the regulation of the circ_0078710/miR-378b/PRIM2 axis.	Curcumin	0-8	microRNA 378b	Homo sapiens	104-112
34139933-0	2021	Curcumin restrains hepatocellular carcinoma progression depending on the regulation of the circ_0078710/miR-378b/PRIM2 axis.	Curcumin	0-8	DNA primase subunit 2	Homo sapiens	113-118
34139933-11	2021	Circ_0078710 interference-induced effects in curcumin-stimulated HCC cells were partly abolished by the silence of miR-378b.	Curcumin	45-53	microRNA 378b	Homo sapiens	115-123
34139933-15	2021	CONCLUSIONS: Circ_0078710 silencing aggravated curcumin-mediated anti-tumor effects through mediating the miR-378b/PRIM2 signaling in HCC cells.	Curcumin	47-55	microRNA 378b	Homo sapiens	106-114
34139933-15	2021	CONCLUSIONS: Circ_0078710 silencing aggravated curcumin-mediated anti-tumor effects through mediating the miR-378b/PRIM2 signaling in HCC cells.	Curcumin	47-55	DNA primase subunit 2	Homo sapiens	115-120
34135585-7	2021	Significantly, the mechanism analysis revealed that curcumin and combretastatin A-4 phosphate could inhibit tumor angiogenesis and metastasis via down-regulation of VEGF and VEGFR2 expression, respectively, and that GA&Gal-Lip could improve antitumor effect by GA/Gal-mediated active-targeting delivery.	Curcumin	52-60	kinase insert domain receptor	Homo sapiens	174-180
34103964-2	2021	This study aimed to determine whether curcumin exerts a chondroprotective effect by inhibiting apoptosis via upregulation of E2F1/PITX1 and activation of autophagy via the Akt/mTOR pathway by targeting microRNA-34a (miR-34a).	Curcumin	38-46	paired-like homeodomain 1	Rattus norvegicus	130-135
34103964-2	2021	This study aimed to determine whether curcumin exerts a chondroprotective effect by inhibiting apoptosis via upregulation of E2F1/PITX1 and activation of autophagy via the Akt/mTOR pathway by targeting microRNA-34a (miR-34a).	Curcumin	38-46	mechanistic target of rapamycin kinase	Rattus norvegicus	176-180
34103964-12	2021	Greater numbers of apoptotic cells, lesser expression of p62, p-Akt, and p-mTOR, and greater expression of E2F1, PITX1, and LC3B were observed in the agomir-34a and high-dose curcumin-treated group than in agomir-34a and low-dose curcumin-treated group.	Curcumin	175-183	mechanistic target of rapamycin kinase	Rattus norvegicus	75-79
34103964-12	2021	Greater numbers of apoptotic cells, lesser expression of p62, p-Akt, and p-mTOR, and greater expression of E2F1, PITX1, and LC3B were observed in the agomir-34a and high-dose curcumin-treated group than in agomir-34a and low-dose curcumin-treated group.	Curcumin	175-183	paired-like homeodomain 1	Rattus norvegicus	113-118
34103964-13	2021	Conclusion: Curcumin"s chondroprotective effect was mediated by its suppression of miR-34a, apparently by reducing apoptosis, via upregulation of E2F1/PITX1, and by augmenting autophagy, likely via the Akt/mTOR pathway.	Curcumin	12-20	paired-like homeodomain 1	Rattus norvegicus	151-156
34103964-13	2021	Conclusion: Curcumin"s chondroprotective effect was mediated by its suppression of miR-34a, apparently by reducing apoptosis, via upregulation of E2F1/PITX1, and by augmenting autophagy, likely via the Akt/mTOR pathway.	Curcumin	12-20	mechanistic target of rapamycin kinase	Rattus norvegicus	206-210
34917292-0	2021	Pharmacological and Molecular Evidence of Neuroprotective Curcumin Effects Against Biochemical and Behavioral Sequels Caused by Methamphetamine: Possible Function of CREB-BDNF Signaling Pathway.	Curcumin	58-66	brain-derived neurotrophic factor	Rattus norvegicus	171-175
34917292-8	2021	Conclusion: Different doses of curcumin adversely attenuated METH-induced apoptosis, oxidative stress, and inflammation but enhanced the concentrations of P-CREB and BDNF.	Curcumin	31-39	brain-derived neurotrophic factor	Rattus norvegicus	166-170
34917292-9	2021	The neuroprotection caused by curcumin against METH-induced neurodegeneration is mediated through P-CREB-BDNF signaling pathway activation.	Curcumin	30-38	brain-derived neurotrophic factor	Rattus norvegicus	105-109
34272350-0	2021	Curcumin improves experimentally induced colitis in mice by regulating follicular helper T cells and follicular regulatory T cells by inhibiting interleukin-21.	Curcumin	0-8	interleukin 21	Mus musculus	145-159
34272350-1	2021	To determine whether curcumin (Cur) can treat mice with experimentally-induced colitis by regulating follicular helper T cells (Tfh) and follicular regulatory T cells (Tfr) by inhibiting interleukin (IL)-21.	Curcumin	21-29	interleukin 21	Mus musculus	187-206
34272350-9	2021	Curcumin may have a potential therapeutic effect on mice with colitis treated experimentally through regulation of the balance of Tfh and Tfr cells via inhibiting the synthesis of IL-21.	Curcumin	0-8	interleukin 21	Mus musculus	180-185
35490921-9	2022	Curcumin prevented the change of expression of 13 proteins involved in oxidative phosphorylation (NDUFB8, NDUFB3, and ATP5L) in the cellular response to stress (PSMA5, HIST1H1D) and lipid metabolism (THRSP, DGAT1, ECI1, and ACOT13).	Curcumin	0-8	proteasome subunit alpha 5	Mus musculus	161-166
35490921-9	2022	Curcumin prevented the change of expression of 13 proteins involved in oxidative phosphorylation (NDUFB8, NDUFB3, and ATP5L) in the cellular response to stress (PSMA5, HIST1H1D) and lipid metabolism (THRSP, DGAT1, ECI1, and ACOT13).	Curcumin	0-8	H1.3 linker histone, cluster member	Mus musculus	168-176
35490921-9	2022	Curcumin prevented the change of expression of 13 proteins involved in oxidative phosphorylation (NDUFB8, NDUFB3, and ATP5L) in the cellular response to stress (PSMA5, HIST1H1D) and lipid metabolism (THRSP, DGAT1, ECI1, and ACOT13).	Curcumin	0-8	thyroid hormone responsive	Mus musculus	200-205
35490921-9	2022	Curcumin prevented the change of expression of 13 proteins involved in oxidative phosphorylation (NDUFB8, NDUFB3, and ATP5L) in the cellular response to stress (PSMA5, HIST1H1D) and lipid metabolism (THRSP, DGAT1, ECI1, and ACOT13).	Curcumin	0-8	acyl-CoA thioesterase 13	Mus musculus	224-230
35550528-0	2022	Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy.	Curcumin	0-8	PTEN induced kinase 1	Rattus norvegicus	83-88
35550528-11	2022	The chondroprotective effects of curcumin against OA are mediated by the AMPK/PINK1/Parkin pathway, and curcumin may serve as a potential novel drug for OA management.	Curcumin	33-41	PTEN induced kinase 1	Rattus norvegicus	78-83
35490494-14	2022	In addition, the active ingredients of herbs (resveratrol, thujaplicins, huperzine, and curcumin) could activate the activity of SIRT1 or SIRT3, thereby improving AKI.	Curcumin	88-96	sirtuin 1	Homo sapiens	129-134
35556131-8	2022	Multiple regression models showed a significant effect of curcumin supplementation in decreasing the worsening of the clinical parameters and p-syn load at after curcumin treatment.	Curcumin	58-66	synemin	Homo sapiens	144-147
35556131-8	2022	Multiple regression models showed a significant effect of curcumin supplementation in decreasing the worsening of the clinical parameters and p-syn load at after curcumin treatment.	Curcumin	162-170	synemin	Homo sapiens	144-147
35556131-9	2022	These data suggest that curcumin can cross the blood-brain barrier, that it is effective in ameliorating clinical parameters and that it shows a tendency to decrease skin p-syn accumulation in PD patients.	Curcumin	24-32	synemin	Homo sapiens	173-176
35609329-10	2022	Moreover, curcumin suppressed the inflammatory response by reducing TNF-alpha, IL-6, and IL-17 secretion in CIA-stimulated mice.	Curcumin	10-18	interleukin 17A	Mus musculus	89-94
35609329-11	2022	Curcumin has an excellent anti-RA effect in vivo and in vitro, which is exerted by inhibiting the expression of pro-inflammatory factors TNF-a, IL-6 and IL-17 and inhibiting the activation of PI3K/AKT signaling pathway.	Curcumin	0-8	interleukin 17A	Mus musculus	153-158
35122926-4	2022	With the incubation of curcumin (1 muM), 6-OHDA-induced apoptosis was suppressed, increasing the autophagy markers (LC3-II/LC3-I, Beclin-1) and inhibiting phosphor-AKT/AKT, phosphor-mTOR/mTOR.	Curcumin	23-31	mechanistic target of rapamycin kinase	Rattus norvegicus	182-186
35122926-4	2022	With the incubation of curcumin (1 muM), 6-OHDA-induced apoptosis was suppressed, increasing the autophagy markers (LC3-II/LC3-I, Beclin-1) and inhibiting phosphor-AKT/AKT, phosphor-mTOR/mTOR.	Curcumin	23-31	mechanistic target of rapamycin kinase	Rattus norvegicus	187-191
35572136-7	2022	In addition, PTAFR was a putative target of anti-AD compounds, including EGCG, donepezil, curcumin, memantine, and Huperzine A.	Curcumin	90-98	platelet-activating factor receptor	Mus musculus	13-18
35564180-6	2022	In an in silico molecular docking study of the gallium-curcumin complex in PDI, calnexin, HSP60, PDK, caspase 9, Akt1 and PTEN were found to be strong binding.	Curcumin	55-63	heat shock protein family D (Hsp60) member 1	Homo sapiens	90-95
35458704-7	2022	Although LPS increased AhR and its target gene CYP1B1, curcumin further enhanced LPS-induced CYP1B1 and indoleamine 2,3-dioxygenase (IDO), which metabolizes tryptophan to AhR ligands kynurenine (KYN) and kynurenic acid (KYNA).	Curcumin	55-63	aryl hydrocarbon receptor	Rattus norvegicus	171-174
35473503-0	2022	Curcumin relieved the rheumatoid arthritis progression via modulating the linc00052/miR-126-5p/PIAS2 axis.	Curcumin	0-8	long intergenic non-protein coding RNA 52	Homo sapiens	74-83
35473503-10	2022	Moreover, curcumin increased linc00052 levels, and linc00052 knockdown reversed the effects of curcumin.	Curcumin	10-18	long intergenic non-protein coding RNA 52	Homo sapiens	29-38
35473503-10	2022	Moreover, curcumin increased linc00052 levels, and linc00052 knockdown reversed the effects of curcumin.	Curcumin	95-103	long intergenic non-protein coding RNA 52	Homo sapiens	51-60
35361044-0	2022	Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity.	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	138-142
35192145-0	2022	Curcumin Inhibits Cell Damage and Apoptosis Caused by Thapsigargin-Induced Endoplasmic Reticulum Stress Involving the Recovery of Mitochondrial Function Mediated by Mitofusin-2.	Curcumin	0-8	mitofusin 2	Homo sapiens	165-176
35192145-7	2022	Curcumin attenuated TG-induced damage on cell viability and apoptosis and downregulated the protein levels of GRP78, pSer981-PERK, and pSer51-eIF2alpha.	Curcumin	0-8	eukaryotic translation initiation factor 2A	Homo sapiens	142-151
35192145-11	2022	Curcumin attenuated the TG-induced Mfn2 expression and mitochondrial stress.	Curcumin	0-8	mitofusin 2	Homo sapiens	35-39
35192145-12	2022	When Mfn2 was silenced by shRNA interference, curcumin failed to recovery the TG-damaged mitochondrial function.	Curcumin	46-54	mitofusin 2	Homo sapiens	5-9
35192145-15	2022	Mfn2 is required for curcumin"s protection against the TG-induced damage on mitochondrial functions.	Curcumin	21-29	mitofusin 2	Homo sapiens	0-4
35303193-6	2022	Foam cells were treated with pre-degraded PLLA powder, curcumin and PPARgamma inhibitor GW9662, and the expression of IL-6, IL-10, TNF-alpha, NF-kappab, PLA2 and PPARgamma were investigated by ELISA or RT-qPCR.	Curcumin	55-63	interleukin 10	Homo sapiens	124-129
35256924-10	2022	In conclusion, our findings indicate that curcumin promotes apoptosis and suppresses proliferation and the Warburg effect by inhibiting LINC00691 in B-CPAP cells.	Curcumin	42-50	long intergenic non-protein coding RNA 691	Homo sapiens	136-145
35184332-0	2022	Synergistic effect of curcumin and resveratrol on the prevention of contrast-induced nephropathy by suppressing inflammation via regulating signaling pathways of microRNA-17/TXNIP/NRLP3 and microRNA-30c/FOXO3/NRLP3.	Curcumin	22-30	thioredoxin interacting protein	Rattus norvegicus	174-179
35041678-9	2022	Further studies revealed that curcumin facilitated solute carrier family 1 member 5 (SLC1A5)-mediated ferroptosis in both MDA-MB-453 and MCF-7 cells by enhancing lipid ROS levels, lipid peroxidation end-product MDA accumulation, and intracellular Fe2+ levels.	Curcumin	30-38	solute carrier family 1 member 5	Homo sapiens	51-83
35041678-9	2022	Further studies revealed that curcumin facilitated solute carrier family 1 member 5 (SLC1A5)-mediated ferroptosis in both MDA-MB-453 and MCF-7 cells by enhancing lipid ROS levels, lipid peroxidation end-product MDA accumulation, and intracellular Fe2+ levels.	Curcumin	30-38	solute carrier family 1 member 5	Homo sapiens	85-91
35041678-11	2022	Collectively, the results demonstrated that curcumin exhibited antitumorigenic activity in BC by promoting SLC1A5-mediated ferroptosis, which suggests its use as a potential therapeutic agent for the treatment of BC.	Curcumin	44-52	solute carrier family 1 member 5	Homo sapiens	107-113
34491302-9	2022	This has led to the introduction of several first-in-class pharmaceuticals with actions targeted at inhibiting the various phases of amyloidosis: TTR stabilizers include diflunisal and first-in-class, Food and Drug Administration (FDA)-approved tafamidis; TTR silencers include patisiran and inotersen; fibril disrupters include doxycycline with tauroursodeoxycholic acid; and alternative agents include green tea extract and curcumin.	Curcumin	426-434	transthyretin	Homo sapiens	146-149
35181615-8	2022	CONCLUSION: By targeting the Sirt1, EZH2 and CXCR4 pathways using relatively non-toxic adjuvant therapeutic agents such as metformin, melatonin, curcumin, sulforaphane, vitamin D3 and plerixafor, we should be able to target the biology of DLBCL.	Curcumin	145-153	sirtuin 1	Homo sapiens	29-34
34109436-0	2021	Curcumin induces apoptosis by inhibiting BCAT1 expression and mTOR signaling in cytarabine-resistant myeloid leukemia cells.	Curcumin	0-8	branched chain amino acid transaminase 1	Homo sapiens	41-46
34109436-7	2021	The present study aimed to investigate whether curcumin induces apoptosis by regulating BCAT1 expression and mTOR signaling in cytarabine-resistant myeloid leukemia cells.	Curcumin	47-55	branched chain amino acid transaminase 1	Homo sapiens	88-93
34109436-8	2021	Four leukemia cell lines and three primary myeloid leukemia cells were treated with curcumin, and the expression and activity of BCAT1 and mTOR were investigated by reverse transcription-quantitative PCR, western blotting and alpha-KG quantification assay.	Curcumin	84-92	branched chain amino acid transaminase 1	Homo sapiens	129-134
34109436-9	2021	The results demonstrated that curcumin inhibited BCAT1 expression in Kasumi-1, KG-1, HL60, cytarabine-resistant HL60, and cytarabine-resistant primary myeloid leukemia cells.	Curcumin	30-38	branched chain amino acid transaminase 1	Homo sapiens	49-54
34109436-12	2021	The present results indicated that curcumin may induce apoptosis by inhibiting the BCAT1 and mTOR pathways.	Curcumin	35-43	branched chain amino acid transaminase 1	Homo sapiens	83-88
34337082-0	2021	RNA-seq and In Vitro Experiments Reveal the Protective Effect of Curcumin against 5-Fluorouracil-Induced Intestinal Mucositis via IL-6/STAT3 Signaling Pathway.	Curcumin	65-73	signal transducer and activator of transcription 3	Rattus norvegicus	135-140
34337082-7	2021	Further RNA-sequencing analysis and experiment validation found that curcumin displays its protective effect against 5-FU-induced IM in intestinal epithelial cells by the inhibition of IL-6/STAT3 signaling pathway.	Curcumin	69-77	signal transducer and activator of transcription 3	Rattus norvegicus	190-195
34305950-4	2021	We found that, in apolipoprotein E deficient mice, sc treatment with curcumin following the REMID strategy induced atheroprotection that was not consequence of its direct systemic lipid-modifying or antioxidant activity, but instead paralleled immunomodulatory effects, such as reduced proatherogenic IFNgamma/TNFalpha-producing cells and increased atheroprotective FOXP3+ Tregs and IL-10-producing dendritic and B cells.	Curcumin	69-77	forkhead box P3	Mus musculus	366-371
34192476-0	2021	Curcumin arrests G-quadruplex in the nuclear hyper-sensitive III1 element of c-MYC oncogene leading to apoptosis in metastatic breast cancer cells.	Curcumin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	77-82
34192476-5	2021	We have investigated the selective binding-interaction profile of a natural phytophenolic compound Curcumin with native MYC G-quadruplex by conducting an array of biophysical experiments and in silico based Molecular Docking and Molecular Dynamic (MDs) simulation studies.	Curcumin	99-107	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	120-123
34192476-7	2021	We have observed significantly increased stability of MYC-G Quadruplex and thermodynamic spontaneity of Curcumin-MYC GQ binding with negative DeltaG value.	Curcumin	104-112	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	113-116
34192476-9	2021	We have used Curcumin as a model drug to understand the innate mechanism of controlling deregulated MYC back to its basal expression level.	Curcumin	13-21	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	100-103
34192476-10	2021	We have checked MYC-expression at transcriptional and translational level and proceeded for Chromatin Immuno-Precipitation assay (ChIP) to study the occupancy level of SP1, Heterogeneous nuclear ribonucleoprotein K (hnRNPK), Nucleoside Diphosphate Kinase 2 (NM23-H2) and Nucleolin at NHEIII1 upon Curcumin treatment of MDA-MB-231 cells.	Curcumin	297-305	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	258-265
34192476-11	2021	We have concluded that Curcumin binding tends to drive the equilibrium towards stable G-quadruplex formation repressing MYC back to its threshold-level.	Curcumin	23-31	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	120-123
34192476-12	2021	On retrospection of the synergistic effect of upregulated c-MYC and BCL-2 in cancer, we have also reported a new pathway (MYC-E2F-1-BCL-2-axis) through which Curcumin trigger apoptosis in cancer cells.Communicated by Ramaswamy H. Sarma.	Curcumin	158-166	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	58-63
34234410-9	2021	Results: A total of 16 target genes of curcumin and GBM were obtained, among which ENO1, MMP2, and PRKD2 significantly affected the prognosis (P < 0.05).	Curcumin	39-47	enolase 1	Homo sapiens	83-87
34234410-12	2021	Conclusion: ENO1 could be a possible target for curcumin in the suppression of GBM cells.	Curcumin	48-56	enolase 1	Homo sapiens	12-16
34207376-0	2021	Single-Oocyte Gene Expression Suggests That Curcumin Can Protect the Ovarian Reserve by Regulating the PTEN-AKT-FOXO3a Pathway.	Curcumin	44-52	phosphatase and tensin homolog	Homo sapiens	103-107
34207376-6	2021	Mechanistic studies show that curcumin can affect the translocation of FOXO3, thereby inhibiting the PTEN-AKT-FOXO3a pathway and protecting primordial follicles from overactivation.	Curcumin	30-38	phosphatase and tensin homolog	Homo sapiens	101-105
34078082-5	2021	The anticancer drug nanoparticles with docetaxel (DTX) and curcumin (CCM) were prepared by coassembly with Lig/Chi NPs in a microreactor, which had good drug loading efficiency, biocompatibility, and can release drugs in response to pH in the weakly acidic environment of the tumor.	Curcumin	59-67	ubiquitin conjugating enzyme E2 K	Homo sapiens	107-110
34078082-5	2021	The anticancer drug nanoparticles with docetaxel (DTX) and curcumin (CCM) were prepared by coassembly with Lig/Chi NPs in a microreactor, which had good drug loading efficiency, biocompatibility, and can release drugs in response to pH in the weakly acidic environment of the tumor.	Curcumin	69-72	ubiquitin conjugating enzyme E2 K	Homo sapiens	107-110
34311526-5	2021	Following LPS/PS treatment, curcumin (oral, 100 mg/kg; a potent NLRP3 modulator) was administered for 2 weeks in the curcumin treatment group, and normal saline was used for the sham group.	Curcumin	28-36	NLR family, pyrin domain containing 3	Mus musculus	64-69
34311526-9	2021	The downregulation of the NLRP3 inflammasome/IL-1beta-related TGF-beta/Smad pathway in bladder tissues through curcumin effectively mitigated bladder injury in the LPS/PS model.	Curcumin	111-119	NLR family, pyrin domain containing 3	Mus musculus	26-31
34311526-9	2021	The downregulation of the NLRP3 inflammasome/IL-1beta-related TGF-beta/Smad pathway in bladder tissues through curcumin effectively mitigated bladder injury in the LPS/PS model.	Curcumin	111-119	interleukin 1 alpha	Mus musculus	45-53
34311526-9	2021	The downregulation of the NLRP3 inflammasome/IL-1beta-related TGF-beta/Smad pathway in bladder tissues through curcumin effectively mitigated bladder injury in the LPS/PS model.	Curcumin	111-119	transforming growth factor alpha	Mus musculus	62-70
34311526-10	2021	In conclusion, the NLRP3 inflammasome/IL-1beta-related TGF-beta/Smad pathway plays a crucial role in bladder injury in the LPS/PS model, and modulation of this pathway, such as by using curcumin, can effectively mitigate the sequelae of chronic inflammation-induced IC/BPS.	Curcumin	186-194	NLR family, pyrin domain containing 3	Mus musculus	19-24
34311526-10	2021	In conclusion, the NLRP3 inflammasome/IL-1beta-related TGF-beta/Smad pathway plays a crucial role in bladder injury in the LPS/PS model, and modulation of this pathway, such as by using curcumin, can effectively mitigate the sequelae of chronic inflammation-induced IC/BPS.	Curcumin	186-194	interleukin 1 alpha	Mus musculus	38-46
34311526-10	2021	In conclusion, the NLRP3 inflammasome/IL-1beta-related TGF-beta/Smad pathway plays a crucial role in bladder injury in the LPS/PS model, and modulation of this pathway, such as by using curcumin, can effectively mitigate the sequelae of chronic inflammation-induced IC/BPS.	Curcumin	186-194	transforming growth factor alpha	Mus musculus	55-63
34141179-0	2021	Curcumin nicotinate suppresses abdominal aortic aneurysm pyroptosis via lncRNA PVT1/miR-26a/KLF4 axis through regulating the PI3K/AKT signaling pathway.	Curcumin	0-8	microRNA 26a-1	Mus musculus	84-91
34095313-4	2021	Results: At nontoxic concentrations in normal prostate epithelial RWPE-1 and HPrEC cells, curcumin led to strong cytotoxicity in PC-3AcT cells, including increases in sub-G0/G1 peak, annexin V-PE-positive cells, and ROS levels; loss of mitochondrial membrane potential; reduction of cellular ATP content; DNA damage; and concurrent induction of apoptosis and necroptosis.	Curcumin	90-98	annexin A5	Homo sapiens	183-192
34095313-7	2021	Treatment of 3D spheroids with curcumin decreased cell viability, accompanied by an increase in mediators of apoptosis and necroptosis, including cleaved caspase-3 and cleaved PARP, phospho (p)-RIP3, and p-MLKL proteins.	Curcumin	31-39	myosin phosphatase Rho interacting protein	Homo sapiens	194-198
34095619-3	2021	By encapsulating nanotechnologically-modified curcumin (CNP) and epidermal growth factor (EGF) into the hydrogel, OHA-CMC/CNP/EGF exhibited extraordinary antioxidant, anti-inflammatory, and migration-promoting effects in vitro.	Curcumin	46-54	epidermal growth factor	Homo sapiens	126-129
34981469-9	2021	The expression levels of all tested genes were altered in all treatment groups compared to the control, with that of WNT1, CTNNB1, TCF, MTOR, AKT1, BIRC5, and CCND1 showing the most robust changes in the combined curcumin/berberine/5-FU treatment.	Curcumin	213-221	catenin beta 1	Homo sapiens	123-129
34331689-4	2021	Additionally, curcumin may regulate novel signaling molecules and enzymes involved in the pathophysiology of diabetes, including glucagon-like peptide-1, dipeptidyl peptidase-4, glucose transporters, alpha-glycosidase, alpha-amylase, and peroxisome proliferator-activated receptor gamma (PPARgamma).	Curcumin	14-22	dipeptidyl peptidase 4	Homo sapiens	154-176
34060984-9	2021	Nanoliposomal curcumin inhibitory concentration (IC50) at hours 24, 48, and 72 were 6.41, 3.8, and 2.33 microg mL-1, respectively.	Curcumin	14-22	L1 cell adhesion molecule	Mus musculus	111-115
35579152-0	2022	Synthesis and Potential Antidiabetic Properties of Curcumin-Based Derivatives: An In Vitro and In Silico Study of alpha-Glucosidase and alpha-Amylase Inhibition.	Curcumin	51-59	sucrase-isomaltase	Homo sapiens	114-131
35532254-7	2022	Importantly is to mention that Curcumin, Proanthocyanidin B2, Oleocanthal, Oleuropein Aglycone, Thionine, Resveratrol had been reported as direct inhibitors of tau.	Curcumin	31-39	microtubule associated protein tau	Homo sapiens	160-163
35313339-10	2022	Induction of autophagy by curcumin, an autophagic stimulator, inhibited the expression of PD-L1 and enhanced cytolytic activity of NCL-specific T cells.	Curcumin	26-34	CD274 molecule	Homo sapiens	90-95
35015114-3	2022	RESULTS: In experimental models, curcumin showed its pleiotropic effects in retinal diseases like diabetic retinopathy by increasing anti-oxidant enzymes, upregulating HO-1, nrf2 and reducing or inhibiting inflammatory mediators, growth factors and by inhibiting proliferation and migration of retinal endothelial cells in a dose-dependent manner in HRPC, HREC and ARPE-19 cells.	Curcumin	33-41	heme oxygenase 1	Homo sapiens	168-172
35015114-4	2022	In age-related macular degeneration, curcumin acts by reducing ROS and inhibiting apoptosis inducing proteins and cellular inflammatory genes and upregulating HO-1, thioredoxin and NQO1.	Curcumin	37-45	heme oxygenase 1	Homo sapiens	159-163
35015114-4	2022	In age-related macular degeneration, curcumin acts by reducing ROS and inhibiting apoptosis inducing proteins and cellular inflammatory genes and upregulating HO-1, thioredoxin and NQO1.	Curcumin	37-45	thioredoxin	Homo sapiens	165-176
35015114-5	2022	In retinitis pigmentosa, curcumin has been shown to delay structural defects of P23H gene in P23H-rhodopsin transgenic rats.	Curcumin	25-33	rhodopsin	Rattus norvegicus	98-107
35015114-6	2022	In proliferative vitreoretinopathy, curcumin inhibited the action of EGF in a dose- and time-dependent manner.	Curcumin	36-44	epidermal growth factor	Homo sapiens	69-72
35015114-7	2022	In retinal ischemia reperfusion injury, curcumin downregulates IL-17, IL-23, NFKB, STAT-3, MCP-1 and JNK.	Curcumin	40-48	interleukin 23 subunit alpha	Homo sapiens	70-75
35015114-7	2022	In retinal ischemia reperfusion injury, curcumin downregulates IL-17, IL-23, NFKB, STAT-3, MCP-1 and JNK.	Curcumin	40-48	C-C motif chemokine ligand 2	Homo sapiens	91-96
35437774-2	2022	ATZ challenge diminished luteinizing hormone, follicular stimulating hormone, testosterone and myeloperoxidase enzyme activity, but these effects were attenuated on co-treatment with CUR and QUE.	Curcumin	183-186	myeloperoxidase	Rattus norvegicus	95-110
35431006-8	2022	Curcumin led to an increase in the caspase-9 expression and no effect on caspase-8.	Curcumin	0-8	caspase 9	Homo sapiens	35-44
35431006-10	2022	The induction of the mitochondria-dependent apoptosis pathway of curcumin happened by the modulation in the expression of Bcl2 and Bax genes, resulting in the caspase-9 activation, also curcumin causes the decreasing the expression of the Stat3 in HN-5 cells.	Curcumin	65-73	caspase 9	Homo sapiens	159-168
35431006-10	2022	The induction of the mitochondria-dependent apoptosis pathway of curcumin happened by the modulation in the expression of Bcl2 and Bax genes, resulting in the caspase-9 activation, also curcumin causes the decreasing the expression of the Stat3 in HN-5 cells.	Curcumin	186-194	caspase 9	Homo sapiens	159-168
35453603-2	2022	To this end, the cytotoxic potential of raloxifene and the synthetic curcumin derivative 2,6-bis (pyridin-4-ylmethylene)-cyclohexanone (RL91) was examined in AR-(PC3 and DU145) cells and AR+ (LnCaP) CRPC cells.	Curcumin	69-77	chromobox 8	Homo sapiens	162-165
35229255-8	2022	In addition, curcumin increased the expression of Toll-like receptor 4 (TLR4) in LPS treated VSMCs.	Curcumin	13-21	toll like receptor 4	Homo sapiens	50-70
35229255-8	2022	In addition, curcumin increased the expression of Toll-like receptor 4 (TLR4) in LPS treated VSMCs.	Curcumin	13-21	toll like receptor 4	Homo sapiens	72-76
35454103-5	2022	Using a refined method for obtaining enriched Schwann cell cultures, we evaluated the neurotherapeutic action of low dose curcumin treatment on the PMP22 expression, and on the chaperones and autophagy/mammalian target of rapamycin (mTOR) pathways in Trembler-J and wild-type genotypes.	Curcumin	122-130	peripheral myelin protein 22	Homo sapiens	148-153
35063475-9	2022	Curcumin reduced the accumulation of AFB1-DNA adducts in the liver and alleviated hepatotoxicity by inhibiting AFB1-induced oxidative stress and potentiating glutathione S-transferase (GST)-mediated phase II detoxification.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Mus musculus	158-183
35063475-9	2022	Curcumin reduced the accumulation of AFB1-DNA adducts in the liver and alleviated hepatotoxicity by inhibiting AFB1-induced oxidative stress and potentiating glutathione S-transferase (GST)-mediated phase II detoxification.	Curcumin	0-8	hematopoietic prostaglandin D synthase	Mus musculus	185-188
35063475-10	2022	In addition, curcumin significantly reduced the characteristic indices of AFB1-induced pyroptosis, such as the expression of mRNAs for genes related to NOD-like receptor protein 3 (NLRP3) inflammasome assembly and activation, the expression of key proteins (NLRP3, Caspase-1 and GSDMD).	Curcumin	13-21	NLR family, pyrin domain containing 3	Mus musculus	152-179
35063475-10	2022	In addition, curcumin significantly reduced the characteristic indices of AFB1-induced pyroptosis, such as the expression of mRNAs for genes related to NOD-like receptor protein 3 (NLRP3) inflammasome assembly and activation, the expression of key proteins (NLRP3, Caspase-1 and GSDMD).	Curcumin	13-21	NLR family, pyrin domain containing 3	Mus musculus	181-186
35063475-10	2022	In addition, curcumin significantly reduced the characteristic indices of AFB1-induced pyroptosis, such as the expression of mRNAs for genes related to NOD-like receptor protein 3 (NLRP3) inflammasome assembly and activation, the expression of key proteins (NLRP3, Caspase-1 and GSDMD).	Curcumin	13-21	NLR family, pyrin domain containing 3	Mus musculus	258-263
35063475-12	2022	Notably, administration of curcumin upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its related downstream antioxidant molecules (SOD, CAT, HO-1, NQO1) and phase II detoxification enzyme-related molecules (GST, GSH, GSS, GCLC, GCLM) in the presence of AFB1 exposure.	Curcumin	27-35	hematopoietic prostaglandin D synthase	Mus musculus	243-246
35063475-12	2022	Notably, administration of curcumin upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its related downstream antioxidant molecules (SOD, CAT, HO-1, NQO1) and phase II detoxification enzyme-related molecules (GST, GSH, GSS, GCLC, GCLM) in the presence of AFB1 exposure.	Curcumin	27-35	glutamate-cysteine ligase, modifier subunit	Mus musculus	264-268
35063475-13	2022	To summarize, our results indicated that curcumin could modulate the NLRP3 inflammasome and Nrf2 signaling pathways to attenuate AFB1-induced liver pyroptotic damage and oxidative stress.	Curcumin	41-49	NLR family, pyrin domain containing 3	Mus musculus	69-74
35166283-6	2022	Furthermore, the antioxidant and acetylcholinesterase (AChE) inhibitory activities of the recovered curcumin were evaluated, with IC50 values of 25.58 +- 0.51 and 19.12 +- 0.83 mug mL-1, respectively.	Curcumin	100-108	L1 cell adhesion molecule	Mus musculus	181-185
35107458-1	2022	Curcumin derivatives B and N were developed as disaggregation agents of amyloid beta (Abeta) fibrils.	Curcumin	0-8	beta amyloid protein precursor-like	Drosophila melanogaster	86-91
35151347-0	2022	Curcumin assists anti-EV71 activity of IFN-alpha by inhibiting IFNAR1 reduction in SH-SY5Y cells.	Curcumin	0-8	interferon alpha and beta receptor subunit 1	Homo sapiens	63-69
35151347-13	2022	Furthermore, EV71 also reduced IFNAR1 protein with proteasome-dependence in SH-SY5Y cells, which can be reversed by Curcumin addition with the evidence that it lowered proteasome activity.	Curcumin	116-124	interferon alpha and beta receptor subunit 1	Homo sapiens	31-37
35151347-14	2022	CONCLUSION: These data demonstrate that Curcumin assists anti-EV71 activity of IFN-alpha by inhibiting IFNAR1 reduction via ubiquitin-proteasome disruption in SH-SY5Y cells.	Curcumin	40-48	interferon alpha and beta receptor subunit 1	Homo sapiens	103-109
35040210-6	2022	Besides, a considerable difference was observed between the nano-curcumin and control groups in the expression of IFN-gamma (p = 0.001), IL-1beta (p = 0.0002), and IL-6 (p = 0.008).	Curcumin	65-73	interleukin 1 alpha	Homo sapiens	137-145
35040210-7	2022	In addition, there was a significant difference between the nano-curcumin and control groups in the serum levels of IL-1beta (p = 0.042).	Curcumin	65-73	interleukin 1 alpha	Homo sapiens	116-124
35078445-12	2022	In vitro, we further confirmed that curcumin significantly downregulated the expression of AURKA, CDK1, and TOP2A genes, while significantly upregulated the expression of CYP2B6, CYP2C9, and CYP3A4 genes.	Curcumin	36-44	cyclin dependent kinase 1	Homo sapiens	98-102
35078445-12	2022	In vitro, we further confirmed that curcumin significantly downregulated the expression of AURKA, CDK1, and TOP2A genes, while significantly upregulated the expression of CYP2B6, CYP2C9, and CYP3A4 genes.	Curcumin	36-44	DNA topoisomerase II alpha	Homo sapiens	108-113
35078445-12	2022	In vitro, we further confirmed that curcumin significantly downregulated the expression of AURKA, CDK1, and TOP2A genes, while significantly upregulated the expression of CYP2B6, CYP2C9, and CYP3A4 genes.	Curcumin	36-44	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	179-185
35078445-13	2022	CONCLUSIONS: Our results provided a novel panel of AURKA, CDK1, TOP2A, CYP2C9, and CYP3A4 candidate genes for curcumin related chemotherapy of hepatocellular carcinoma.	Curcumin	110-118	cyclin dependent kinase 1	Homo sapiens	58-62
35078445-13	2022	CONCLUSIONS: Our results provided a novel panel of AURKA, CDK1, TOP2A, CYP2C9, and CYP3A4 candidate genes for curcumin related chemotherapy of hepatocellular carcinoma.	Curcumin	110-118	DNA topoisomerase II alpha	Homo sapiens	64-69
35078445-13	2022	CONCLUSIONS: Our results provided a novel panel of AURKA, CDK1, TOP2A, CYP2C9, and CYP3A4 candidate genes for curcumin related chemotherapy of hepatocellular carcinoma.	Curcumin	110-118	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	71-77
35011106-8	2022	Curcumin significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-gamma, and IL-4) and lipid peroxidation.	Curcumin	0-8	C-C motif chemokine ligand 2	Homo sapiens	66-71
3139287-2	1988	Topical application of 0.5, 1, 3, or 10 mumol of curcumin inhibited by 31, 46, 84, or 98%, respectively, the induction of epidermal ornithine decarboxylase activity by 5 nmol of TPA.	Curcumin	49-57	ornithine decarboxylase, structural 1	Mus musculus	132-155
3139287-3	1988	In an additional study, the topical application of 10 mumol of curcumin, chlorogenic acid, caffeic acid, or ferulic acid inhibited by 91, 25, 42, or 46%, respectively, the induction of ornithine decarboxylase activity by 5 nmol of TPA.	Curcumin	63-71	ornithine decarboxylase, structural 1	Mus musculus	185-208
33910718-6	2021	The applicability for drug delivery was evaluated by the addition of curcumin to printable A-CNF formulations.	Curcumin	69-77	NPHS1 adhesion molecule, nephrin	Homo sapiens	93-96
33910718-7	2021	The curcumin loaded bioinks were successfully 3D printed in patches and the in vitro release tests showed that alginate and CNF played an important role in curcumin stabilization, whereas the CNF content and the disintegration of the scaffold were essential in the release kinetics.	Curcumin	4-12	NPHS1 adhesion molecule, nephrin	Homo sapiens	124-127
33910718-7	2021	The curcumin loaded bioinks were successfully 3D printed in patches and the in vitro release tests showed that alginate and CNF played an important role in curcumin stabilization, whereas the CNF content and the disintegration of the scaffold were essential in the release kinetics.	Curcumin	4-12	NPHS1 adhesion molecule, nephrin	Homo sapiens	192-195
33910718-7	2021	The curcumin loaded bioinks were successfully 3D printed in patches and the in vitro release tests showed that alginate and CNF played an important role in curcumin stabilization, whereas the CNF content and the disintegration of the scaffold were essential in the release kinetics.	Curcumin	156-164	NPHS1 adhesion molecule, nephrin	Homo sapiens	124-127
34051214-4	2021	Immunoblot analysis demonstrated that among the 21 different polyphenols tested, curcumin most potently increased HSP70 levels in Caco-2 cells without affecting cell viability.	Curcumin	81-89	heat shock protein family A (Hsp70) member 4	Homo sapiens	114-119
34051214-5	2021	Curcumin also increased the phosphorylation of heat shock factor 1 (HSF1), a well-known transcription factor of HSP70.	Curcumin	0-8	heat shock protein family A (Hsp70) member 4	Homo sapiens	112-117
34051214-7	2021	Pharmacological inhibition of MEK, a mechanistic target of rapamycin, p38 mitogen-activated protein kinase, and phosphatidyl 3-inositol kinase suppressed curcumin-mediated HSP70 expression, whereas HSF1 phosphorylation was sensitive only to MEK inhibition.	Curcumin	154-162	heat shock protein family A (Hsp70) member 4	Homo sapiens	172-177
34051214-8	2021	Taken together, curcumin increases the expression of HSP70 in intestinal Caco-2 cells via transcriptional activation, possibly enhancing cell integrity.	Curcumin	16-24	heat shock protein family A (Hsp70) member 4	Homo sapiens	53-58
34002390-0	2021	Development of Cress Seed Gum Hydrogel and Investigation of its Potential Application in the Delivery of Curcumin.	Curcumin	105-113	OTU deubiquitinase with linear linkage specificity	Homo sapiens	26-29
34002390-2	2021	Cress Seed Gum (CSG) with high thermal stability can be a promising polysaccharide to prepare physically cross-linked hydrogel as a curcumin delivery system.	Curcumin	132-140	OTU deubiquitinase with linear linkage specificity	Homo sapiens	11-14
34002390-7	2021	CONCLUSION: As a result, cress seed gum hydrogel can protect curcumin during food thermal processing and digestion time.	Curcumin	61-69	OTU deubiquitinase with linear linkage specificity	Homo sapiens	36-39
33880847-0	2021	Curcumin prevents obesity by targeting TRAF4-induced ubiquitylation in m6 A-dependent manner.	Curcumin	0-8	TNF receptor associated factor 4	Mus musculus	39-44
33880847-5	2021	Mechanistically, curcumin inhibits adipogenesis by reducing the expression of AlkB homolog 5 (ALKHB5), an m6 A demethylase, which leads to higher m6 A-modified TNF receptor-associated factor 4 (TRAF4) mRNA.	Curcumin	17-25	TNF receptor associated factor 4	Mus musculus	160-192
33880847-5	2021	Mechanistically, curcumin inhibits adipogenesis by reducing the expression of AlkB homolog 5 (ALKHB5), an m6 A demethylase, which leads to higher m6 A-modified TNF receptor-associated factor 4 (TRAF4) mRNA.	Curcumin	17-25	TNF receptor associated factor 4	Mus musculus	194-199
33880847-8	2021	Thus, m6 A-dependent TRAF4 expression upregulation by ALKBH5 and YTHDF1 contributes to curcumin-induced obesity prevention.	Curcumin	87-95	TNF receptor associated factor 4	Mus musculus	21-26
33880847-8	2021	Thus, m6 A-dependent TRAF4 expression upregulation by ALKBH5 and YTHDF1 contributes to curcumin-induced obesity prevention.	Curcumin	87-95	YTH N6-methyladenosine RNA binding protein 1	Mus musculus	65-71
33673981-0	2021	Wound healing performance of PCL/chitosan based electrospun nanofiber electrosprayed with curcumin loaded chitosan nanoparticles.	Curcumin	90-98	PHD finger protein 1	Homo sapiens	29-32
33673981-1	2021	In this study, the electrospun poly(epsilon-caprolactone) (PCL)/Chitosan (CS)/curcumin (CUR) nanofiber was fabricated successfully with curcumin loaded chitosan nano-encapsulated particles (CURCSNPs).	Curcumin	136-144	PHD finger protein 1	Homo sapiens	59-62
33450459-4	2021	BLG) cross-linked with epsilon poly l-lysine (BCEP and BCP), and found to possess high loading capacity, high aqueous solubility and site-specific oral delivery of a poorly soluble nutraceutical (curcumin), improving its physicochemical properties and biological activity in-vitro and ex-vivo.	Curcumin	196-204	beta-lactoglobulin	Bos taurus	0-3
33450459-6	2021	By forming nanocomplexes of curcumin with BLG and succ.	Curcumin	28-36	beta-lactoglobulin	Bos taurus	42-45
33450459-7	2021	BLG, the aqueous solubility of curcumin was markedly increased by ~160-fold and ~86-fold, respectively.	Curcumin	31-39	beta-lactoglobulin	Bos taurus	0-3
33450459-9	2021	BLG prevent release of encapsulated curcumin when subjected to gastric fluids as it is resistant to breakdown on exposure to pepsin at acidic pH.	Curcumin	36-44	beta-lactoglobulin	Bos taurus	0-3
33450459-13	2021	BLG with E-PLL significantly enhanced curcumin"s permeability in an in-vitro Caco-2 cell monolayer model compared to curcumin solution (dissolved in 1% DMSO), or non-crosslinked BLG/succ.	Curcumin	38-46	beta-lactoglobulin	Bos taurus	0-3
33907454-9	2021	Moreover, curcumin treatment increased the number of newly born immature (BrdU/NeuN) and newly generated mature neurons (BrdU/DCX).	Curcumin	10-18	doublecortin	Rattus norvegicus	126-129
33875681-0	2021	Curcumin activates Nrf2 through PKCdelta-mediated p62 phosphorylation at Ser351.	Curcumin	0-8	nucleoporin 62	Homo sapiens	50-53
33875681-4	2021	Notably, the level of p62 phosphorylation at S351 (S349 in human) was significantly increased in cells treated with curcumin.	Curcumin	116-124	nucleoporin 62	Homo sapiens	22-25
33875681-5	2021	Additionally, curcumin-induced Nrf2 activation was abrogated in p62 knockout (-/-) MEFs, indicating that p62 phosphorylation at S351 played a crucial role in curcumin-induced Nrf2 activation.	Curcumin	14-22	nucleoporin 62	Homo sapiens	64-67
33875681-5	2021	Additionally, curcumin-induced Nrf2 activation was abrogated in p62 knockout (-/-) MEFs, indicating that p62 phosphorylation at S351 played a crucial role in curcumin-induced Nrf2 activation.	Curcumin	14-22	nucleoporin 62	Homo sapiens	105-108
33875681-5	2021	Additionally, curcumin-induced Nrf2 activation was abrogated in p62 knockout (-/-) MEFs, indicating that p62 phosphorylation at S351 played a crucial role in curcumin-induced Nrf2 activation.	Curcumin	158-166	nucleoporin 62	Homo sapiens	64-67
33875681-5	2021	Additionally, curcumin-induced Nrf2 activation was abrogated in p62 knockout (-/-) MEFs, indicating that p62 phosphorylation at S351 played a crucial role in curcumin-induced Nrf2 activation.	Curcumin	158-166	nucleoporin 62	Homo sapiens	105-108
33875681-6	2021	Among the kinases involved in p62 phosphorylation at S351, PKCdelta was activated in curcumin-treated cells.	Curcumin	85-93	nucleoporin 62	Homo sapiens	30-33
33875681-8	2021	Together, these results suggest that PKCdelta is mainly involved in curcumin-induced p62 phosphorylation and Nrf2 activation.	Curcumin	68-76	nucleoporin 62	Homo sapiens	85-88
33875681-9	2021	Accordingly, we demonstrate for the first time that curcumin activates Nrf2 through PKCdelta-mediated p62 phosphorylation at S351.	Curcumin	52-60	nucleoporin 62	Homo sapiens	102-105
33866462-2	2021	Importantly, recent data indicated a protective action of curcumin (CRC) via inhibition of TRPM2 on the inflammation factors, ROS, and apoptosis in hypoxia-induced SH-SY5Y neuronal cells.	Curcumin	58-66	transient receptor potential cation channel subfamily M member 2	Homo sapiens	91-96
33866462-2	2021	Importantly, recent data indicated a protective action of curcumin (CRC) via inhibition of TRPM2 on the inflammation factors, ROS, and apoptosis in hypoxia-induced SH-SY5Y neuronal cells.	Curcumin	68-71	transient receptor potential cation channel subfamily M member 2	Homo sapiens	91-96
33508284-7	2021	The most effective compound oxindole-curcumin hybrid GIF-2165X-G1 increased GCLC mRNA levels in HT22 mouse hippocampal cells, PC12 rat pheochromocytoma cells, and C6 rat glioma cells.	Curcumin	37-45	glutamate-cysteine ligase, catalytic subunit	Mus musculus	76-80
33354908-10	2021	Additionally, curcumin inhibited the PI3K/AKT/mTOR pathway.	Curcumin	14-22	mechanistic target of rapamycin kinase	Rattus norvegicus	46-50
33373686-0	2021	PARP inhibitor Veliparib (ABT-888) enhances the anti-angiogenic potentiality of Curcumin through deregulation of NECTIN-4 in oral cancer: Role of nitric oxide (NO).	Curcumin	80-88	nectin cell adhesion molecule 4	Homo sapiens	113-121
33373686-6	2021	We observed that the soluble NECTIN-4 secreted from H357 oral cancer cells enhanced the angiogenesis of endothelial cells (HUVECs) and this was inhibited by Curcumin-Veliparib combination.	Curcumin	157-165	nectin cell adhesion molecule 4	Homo sapiens	29-37
33373686-11	2021	Curcumin antagonised the NECTIN-4-induced angiogenesis through inhibition of PI3K-AKT mediated eNOS pathway and Veliparib synergized the effect of Curcumin.	Curcumin	0-8	nectin cell adhesion molecule 4	Homo sapiens	25-33
33184809-9	2021	Both the molecules curcumin and catechin get bound directly to receptors binding domain of S-protein and ACE-2 receptors of host cell, due to which these molecules inhibit the entry of virus in host cell i. e. animal survives from being infected.	Curcumin	19-27	vitronectin	Homo sapiens	91-100
33517224-0	2021	Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation.	Curcumin	0-8	cathepsin B	Mus musculus	86-97
33581265-10	2021	Curcumin helps to regulate the balance of antioxidant and reactive oxygen species by targeting various molecules (NF-kappaB, STAT3, MAPK, Mfn2, Nrf2, pro-inflammatory cytokines).	Curcumin	0-8	mitofusin 2	Homo sapiens	138-142
33732362-10	2021	Furthermore, curcumin suppressed the secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte-colony stimulating factor (G-CSF), which are essential factors for MDSCs modulation, in tumor tissues.	Curcumin	13-21	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	50-98
33732362-10	2021	Furthermore, curcumin suppressed the secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte-colony stimulating factor (G-CSF), which are essential factors for MDSCs modulation, in tumor tissues.	Curcumin	13-21	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	100-106
33656766-13	2021	Further investigation suggested that curcumin induced mitochondrial membrane rupture and mitochondrial cristae decrease, increased autolysosome, increased the level of Beclin1 and LC3, and decreased the level of P62.	Curcumin	37-45	beclin 1	Homo sapiens	168-175
33656766-13	2021	Further investigation suggested that curcumin induced mitochondrial membrane rupture and mitochondrial cristae decrease, increased autolysosome, increased the level of Beclin1 and LC3, and decreased the level of P62.	Curcumin	37-45	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	180-183
33656766-13	2021	Further investigation suggested that curcumin induced mitochondrial membrane rupture and mitochondrial cristae decrease, increased autolysosome, increased the level of Beclin1 and LC3, and decreased the level of P62.	Curcumin	37-45	nucleoporin 62	Homo sapiens	212-215
32694760-8	2021	In CCD-18Co cells and RAW264.7 cells, curcumin dose-dependently activated PPARgamma and CREB, whereas PPARgamma antagonist GW9662 (1 muM) or cAMP response element (CREB) inhibitor KG-501 (10 muM) significantly decreased the boosting effect of curcumin on HGF expression.	Curcumin	38-46	hepatocyte growth factor	Mus musculus	255-258
32694760-11	2021	Together, curcumin promotes the expression of HGF in colonic fibroblasts and macrophages by activating PPARgamma and CREB via an induction of 15d-PGJ2, and the HGF enters the lungs giving rise to an anti-PF effect.	Curcumin	10-18	hepatocyte growth factor	Mus musculus	46-49
34014157-15	2021	Nevertheless, curcumin could reverse the HSP65-induced CCL2 upregulation through restraining JAK2/AKT/STAT3 pathway.	Curcumin	14-22	heat shock protein family D (Hsp60) member 1	Homo sapiens	41-46
33669070-0	2021	P62/SQSTM1/Keap1/NRF2 Axis Reduces Cancer Cells Death-Sensitivity in Response to Zn(II)-Curcumin Complex.	Curcumin	88-96	sequestosome 1	Homo sapiens	0-3
33669070-0	2021	P62/SQSTM1/Keap1/NRF2 Axis Reduces Cancer Cells Death-Sensitivity in Response to Zn(II)-Curcumin Complex.	Curcumin	88-96	sequestosome 1	Homo sapiens	4-10
33316116-0	2021	Curcumin analog B14 has high bioavailability and enhances the effect of anti-breast cancer cells in vitro and in vivo.	Curcumin	0-8	NADH:ubiquinone oxidoreductase subunit A6	Homo sapiens	16-19
33316116-2	2021	To address this problem, we tested the efficacy of the synthetic curcumin analog B14 in breast cancer cells and explored the mechanism by which B14 inhibits proliferation and metastasis of breast cancer cells.	Curcumin	65-73	NADH:ubiquinone oxidoreductase subunit A6	Homo sapiens	81-84
33316116-11	2021	Our data reveal the therapeutic potential of the curcumin analogue B14 and the underlying mechanisms to fight breast cancer cells.	Curcumin	49-57	NADH:ubiquinone oxidoreductase subunit A6	Homo sapiens	67-70
33220404-4	2021	Curcumin or its combination with piperine, but not piperine alone, suppressed mTORC1 kinase activity, curtailed lipopolysaccharide-mediated inflammatory response of THP-1 macrophages, and repressed macrophage activation by inhibiting signaling pathways involved in M1 (mTORC1) and M2 (mTORC2, CREB) polarization.	Curcumin	0-8	cAMP responsive element binding protein 1	Homo sapiens	293-297
32686020-6	2021	Curcumin administration could also expand the expression level of Aire from mRNA level and protein level.	Curcumin	0-8	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	Mus musculus	66-70
32686020-7	2021	The current study demonstrated that curcumin could ameliorate senescence-related thymus involution via upregulating Aire expression, suggesting that curcumin can rejuvenate senescence-associated alterations of thymus induced by D-gal accumulation.	Curcumin	36-44	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	Mus musculus	116-120
32686020-7	2021	The current study demonstrated that curcumin could ameliorate senescence-related thymus involution via upregulating Aire expression, suggesting that curcumin can rejuvenate senescence-associated alterations of thymus induced by D-gal accumulation.	Curcumin	149-157	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	Mus musculus	116-120
33747866-9	2021	Regarding cancer metastasis, curcumin and PGV-1 showed inhibitory activities against cell migration and inhibited MMP-2 and MMP-9 protein expression.	Curcumin	29-37	matrix metallopeptidase 2	Mus musculus	114-119
33099890-9	2021	Curcumin regulates several molecules in the intracellular signal transduction pathways involved in inflammation, including IBB, NF-kBERK1,2, AP-1, TGF-beta, TXNIP, STAT3, PPARgamma, JAK2-STAT3, NLRP3, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 and MyD-88.	Curcumin	0-8	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	225-229
33087639-2	2021	H10, a novel curcumin analogue, was identified as a potential 17beta-HSD3 inhibitor.	Curcumin	13-21	H1.0 linker histone	Homo sapiens	0-3
33129903-10	2021	Therefore, nC/R hydrogel could effectively deliver both curcumin and arginine and therapeutically reduce the effect of hypoxia induced endothelial dysfunction.	Curcumin	56-64	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	11-15
33179087-8	2021	Furthermore, curcumin notably decreased the expression levels of epithelial marker E-cadherin and markedly increased the expression levels of mesenchymal marker N-cadherin in MCF-7/TAMR cells compared with the control group.	Curcumin	13-21	cadherin 2	Homo sapiens	161-171
33179087-10	2021	Moreover, curcumin treatment for 48 h significantly attenuated H19-induced alterations in N-cadherin and E-cadherin expression levels.	Curcumin	10-18	cadherin 2	Homo sapiens	90-100
33184252-7	2020	RESULTS The rpS6-phosphorylation was suppressed and light chain 3 (LC3II) expression elevated in the curcumin treated group of the fracture rat model.	Curcumin	101-109	ribosomal protein S6	Rattus norvegicus	12-16
33184252-10	2020	Treatment of rats with curcumin significantly (P<0.05) promoted expression of PCNA and VEGF.	Curcumin	23-31	proliferating cell nuclear antigen	Rattus norvegicus	78-82
33184252-11	2020	The decrease in CD11b+/Gr-1+ cell expansion in rats with bone trauma was alleviated significantly by curcumin treatment.	Curcumin	101-109	integrin subunit alpha M	Homo sapiens	16-21
33184252-13	2020	CONCLUSIONS In summary, curcumin activates autophagy and inhibits mTOR activation in bone tissues of rats with trauma.	Curcumin	24-32	mechanistic target of rapamycin kinase	Rattus norvegicus	66-70
32745765-5	2020	Meanwhile, hypoxic preconditioning combined with curcumin altered mitochondrial cristae shape and strongly inhibited mitochondrial cytochrome c release, which consequently suppressed an apoptosis signal as revealed by reduced caspase-3 cleavage in BMSCs.	Curcumin	49-57	caspase 3	Mus musculus	226-235
32745765-9	2020	MG132 also increased mitochondrial superoxide and intracellular hydrogen peroxide (H2O2) production and caspase-3 activation in hypoxia combined with curcumin-treated BMSCs.	Curcumin	150-158	caspase 3	Mus musculus	104-113
32745765-10	2020	Furthermore, knockdown of SIRT3 and PGC-1alpha by RNAi both led to caspase-3 activation in BMSCs after hypoxia and curcumin treatment.	Curcumin	115-123	caspase 3	Mus musculus	67-76
31983246-0	2020	Thymoquinone and Curcumin combination protects cisplatin-induced Kidney Injury, Nephrotoxicity by attenuating NFkB, KIM-1 and ameliorating Nrf2/HO-1 signaling.	Curcumin	17-25	hepatitis A virus cellular receptor 1	Homo sapiens	116-121
33238792-0	2020	The mechanism of curcumin post-treatment relieving lung injuries by regulating miR-21/TLR4/NF-kappaB signalling pathway.	Curcumin	17-25	microRNA 21	Rattus norvegicus	79-85
33238792-10	2020	An inhibitor of miR-21 (antagomir-21) reversed the protective effects of curcumin.	Curcumin	73-81	microRNA 21	Rattus norvegicus	16-22
33238792-11	2020	CONCLUSION: Curcumin post-treatment can alleviate the lung injuries induced by limb ischaemia-reperfusion via downregulating the levels of miR-21 mRNA.	Curcumin	12-20	microRNA 21	Rattus norvegicus	139-145
32866906-0	2020	Curcumin inhibits proteasome activity in triple-negative breast cancer cells through regulating p300/miR-142-3p/PSMB5 axis.	Curcumin	0-8	proteasome 20S subunit beta 5	Homo sapiens	112-117
32866906-10	2020	RESULTS: Curcumin significantly reduced PSMB5 protein levels, accompanied with a reduction in the chymotrypsin-like (CT-l) activity of proteasome 20S core.	Curcumin	9-17	proteasome 20S subunit beta 5	Homo sapiens	40-45
32866906-19	2020	These curcumin-induced changes on p300, miR-142-3p, PSMB5, and 20S proteasome activity were further confirmed in in vivo solid tumor model.	Curcumin	6-14	proteasome 20S subunit beta 5	Homo sapiens	52-57
32866906-20	2020	CONCLUSION: These findings demonstrated that curcumin suppressed p300/miR-142-3p/PSMB5 axis leading to the inhibition of the CT-l activity of 20S proteasome.	Curcumin	45-53	proteasome 20S subunit beta 5	Homo sapiens	81-86
32822714-8	2020	Curcumin, quercetin, and atorvastatin treatment lead to down-regulation of miR-21 and TGFbeta1 and up-regulation of miR-122 in the BDL groups.	Curcumin	0-8	microRNA 21	Rattus norvegicus	75-81
33061628-0	2020	Curcumin Modifies Epithelial-Mesenchymal Transition in Colorectal Cancer Through Regulation of miR-200c/EPM5.	Curcumin	0-8	prickle planar cell polarity protein 2	Homo sapiens	104-108
33061628-13	2020	Downregulation of EPM5 was necessary for curcumin-repressed EMT, migration, and invasion.	Curcumin	41-49	prickle planar cell polarity protein 2	Homo sapiens	18-22
33061628-15	2020	Conclusion: Our data provide the first evidence that the curcumin inhibits EMT in CRC by upregulation of miR-200c and downregulation of EPM5, and the use of curcumin might be able to prevent or delay CRC progression.	Curcumin	57-65	prickle planar cell polarity protein 2	Homo sapiens	136-140
31900255-10	2020	In this study, we identified that curcumin-O-glucuronide, a major metabolite of curcumin present in plasma and faeces, is a typical substrate of Mrp3 in mice and in humans.	Curcumin	34-42	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	145-149
32860098-0	2020	Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-kappaB/HIF-2alpha axis.	Curcumin	20-28	endothelial PAS domain protein 1	Rattus norvegicus	167-177
32718261-6	2020	Moreover, treatment with PE and/or curcumin exerted a significant upregulation of Nrf2/HO-1 gene expressions along with significant downregulation of NF-kB, TGF-beta, and phospho-Smad3 protein expressions, as well as alpha-SMA and collagen-1 gene expressions.	Curcumin	35-43	heme oxygenase 1	Rattus norvegicus	87-91
32718261-6	2020	Moreover, treatment with PE and/or curcumin exerted a significant upregulation of Nrf2/HO-1 gene expressions along with significant downregulation of NF-kB, TGF-beta, and phospho-Smad3 protein expressions, as well as alpha-SMA and collagen-1 gene expressions.	Curcumin	35-43	transforming growth factor alpha	Rattus norvegicus	157-165
32718261-8	2020	In conclusion, hepatoprotective activities of PE and/or curcumin could be linked to their abilities to modulate Nrf2/HO-1, NF-kappaB, and TGF-beta/Smad3 signaling pathways.	Curcumin	56-64	heme oxygenase 1	Rattus norvegicus	117-121
32718261-8	2020	In conclusion, hepatoprotective activities of PE and/or curcumin could be linked to their abilities to modulate Nrf2/HO-1, NF-kappaB, and TGF-beta/Smad3 signaling pathways.	Curcumin	56-64	transforming growth factor alpha	Rattus norvegicus	138-146
33014113-12	2020	Conclusion: Curcumin can overcome L-OHP resistance in colorectal cancer cells through its effects on miR-409-3p mediated ERCC1 expression.	Curcumin	12-20	microRNA 409	Homo sapiens	101-108
32618472-12	2020	Therapeutic efficacy of curcumin exhibited a protective role against the progression of pulmonary fibrosis, which promises the potent therapeutic modality to target IL-17A mediated p53-fibrinolytic system during pulmonary fibrosis.	Curcumin	24-32	interleukin 17A	Mus musculus	165-171
32757994-10	2020	miR-21-5p level was decreased in curcumin-treated cells, and miR-21-5p overexpression reversed curcumin-mediated inhibition of HCC progression.	Curcumin	33-41	microRNA 215	Homo sapiens	0-9
32757994-10	2020	miR-21-5p level was decreased in curcumin-treated cells, and miR-21-5p overexpression reversed curcumin-mediated inhibition of HCC progression.	Curcumin	95-103	microRNA 215	Homo sapiens	61-70
32757994-12	2020	Moreover, curcumin exposure increased SOX6 expression through regulating miR-21-5p, and knockdown of SOX6 overturned curcumin-modulated suppression of HCC progression.	Curcumin	10-18	microRNA 215	Homo sapiens	73-82
32757994-13	2020	Conclusions: Curcumin repressed proliferation, migration, and invasion of HCC cells by regulating miR-21-5p and SOX6, indicating the promisingly pharmacological effect of curcumin in HCC.	Curcumin	13-21	microRNA 215	Homo sapiens	98-107
32757994-13	2020	Conclusions: Curcumin repressed proliferation, migration, and invasion of HCC cells by regulating miR-21-5p and SOX6, indicating the promisingly pharmacological effect of curcumin in HCC.	Curcumin	171-179	microRNA 215	Homo sapiens	98-107
32535538-0	2020	Effect of curcumin on IL-17A mediated pulmonary AMPK kinase/cyclooxygenase-2 expressions via activation of NFkappaB in bleomycin-induced acute lung injury in vivo.	Curcumin	10-18	interleukin 17A	Mus musculus	22-28
32535538-5	2020	Curcumin could also suppress the expressions of NF-kappaB-p105 in BLM/IL-17A exposed mice.	Curcumin	0-8	interleukin 17A	Mus musculus	70-76
32535538-6	2020	mRNA expressions showed reduced expressions of PDGFA, PDGFB, CTGF, IGF1, NFkappaB1, NFkappaB2, MMP-3, MMP-9, and MMP-14 on curcumin treatment.	Curcumin	123-131	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100	Mus musculus	84-93
32535538-6	2020	mRNA expressions showed reduced expressions of PDGFA, PDGFB, CTGF, IGF1, NFkappaB1, NFkappaB2, MMP-3, MMP-9, and MMP-14 on curcumin treatment.	Curcumin	123-131	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	113-119
32803504-0	2020	Ameliorative effect of curcumin on altered expression of CACNA1A and GABRD in the pathogenesis of FeCl3-induced epilepsy.	Curcumin	23-31	calcium voltage-gated channel subunit alpha1 A	Rattus norvegicus	57-64
32803504-13	2020	Results also demonstrated that curcumin administration ameliorated epilepsy-associated change in expression of both CACNA1A and GABRD proteins.	Curcumin	31-39	calcium voltage-gated channel subunit alpha1 A	Rattus norvegicus	116-123
32576716-5	2020	Curcumin induced cell death through the production of ROS and decreased the activation of survival signals, but PRP4 overexpression reversed the curcumin-induced oxidative stress and apoptosis.	Curcumin	145-153	pre-mRNA processing factor 4B	Homo sapiens	112-116
32576716-11	2020	Collectively, our investigations suggest that the PRP4 kinase domain is responsible for promoting drug resistance to curcumin by inducing EMT.	Curcumin	117-125	pre-mRNA processing factor 4B	Homo sapiens	50-54
32753918-8	2020	Results: Insulin resistance and serum levels of FBS, Apelin, cholesterol, triglycerides, LDL, and VLDL were significantly decreased in diabetic rats treated with curcumin and nano-curcumin (p<0.05) so that nano-curcumin in reducing lipid profile is more effective than curcumin (P<0.05).	Curcumin	162-170	apelin	Rattus norvegicus	53-59
32753918-11	2020	Conclusion: The therapeutic effects of curcumin and nano-curcumin were effective in decreasing insulin resistance, serum levels of FBS, apelin and lipid profile.	Curcumin	39-47	apelin	Rattus norvegicus	136-142
32753918-11	2020	Conclusion: The therapeutic effects of curcumin and nano-curcumin were effective in decreasing insulin resistance, serum levels of FBS, apelin and lipid profile.	Curcumin	57-65	apelin	Rattus norvegicus	136-142
31654258-9	2020	In conclusion, CUR and/or Se mitigated LPS/DCL-induced liver injury in rats by suppressing TLR4 signaling, inflammation, and oxidative stress and boosting HO-1 and other antioxidants.	Curcumin	15-18	heme oxygenase 1	Rattus norvegicus	155-159
32020664-9	2020	In addition, ADMA treatment resulted in similar results to those of TGF-beta1, and Cur significantly attenuated the effect of TGF-beta1, accompanied by increased VE-cadherin, DDAH1 and NRF-2 and decreased matrix metalloproteinase-9 (MMP-9) and extracellular regulated protein kinases 1/2 (ERK1/2) phosphorylation.	Curcumin	83-86	matrix metallopeptidase 9	Homo sapiens	205-231
32020664-9	2020	In addition, ADMA treatment resulted in similar results to those of TGF-beta1, and Cur significantly attenuated the effect of TGF-beta1, accompanied by increased VE-cadherin, DDAH1 and NRF-2 and decreased matrix metalloproteinase-9 (MMP-9) and extracellular regulated protein kinases 1/2 (ERK1/2) phosphorylation.	Curcumin	83-86	matrix metallopeptidase 9	Homo sapiens	233-238
32802291-9	2020	CU+LLLT decreases Bax/Bcl2 ratio which is an indicator of apoptosis and it also rescued a decrease in LC3 and ATG10 expression in comparison with 6-OHDA group.	Curcumin	0-2	autophagy related 10	Rattus norvegicus	110-115
32636613-0	2020	Erratum: Attenuation of Myocardial Fibrosis with Curcumin Is Mediated by Modulating Expression of Angiotensin II AT1/AT2 Receptors and ACE2 in Rats [Corrigendum].	Curcumin	49-57	angiotensin I converting enzyme 2	Rattus norvegicus	135-139
32617134-8	2020	Further, curcumin-induced DNA demethylation of hGCCs was mediated by the damaged DNA repair-p53-p21/GADD45A-cyclin/CDK-Rb/E2F-DNMT1 axis.	Curcumin	9-17	DNA methyltransferase 1	Homo sapiens	126-131
32566072-6	2020	The treatments with curcumin and/or aminoguanidine increased the activities of the antioxidant enzymes (paraoxonase 1, superoxide dismutase, and catalase) and the levels of AGE detoxification system components (AGE-R1 receptor and glyoxalase 1).	Curcumin	20-28	paraoxonase 1	Rattus norvegicus	104-117
31914858-7	2020	Our data shows that Cur inhibited hypoxia-induced HIF1alpha expression and tissue damage by demonstrating the improved morphology of astrocytes and remarkable reduction in vacuolation.	Curcumin	20-23	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	50-59
31914858-8	2020	Cur also inhibited the hypoxia-induced upregulation of glial fibrillary acidic protein (GFAP) and neurofilament-H (NF-H) after hypoxia and downregulated the expression of pro-inflammatory cytokines like TNF-alpha and IL-1.	Curcumin	0-3	neurofilament heavy chain	Rattus norvegicus	98-113
31914858-8	2020	Cur also inhibited the hypoxia-induced upregulation of glial fibrillary acidic protein (GFAP) and neurofilament-H (NF-H) after hypoxia and downregulated the expression of pro-inflammatory cytokines like TNF-alpha and IL-1.	Curcumin	0-3	neurofilament heavy chain	Rattus norvegicus	115-119
32004976-0	2020	Curcumin regulates the differentiation of naive CD4+T cells and activates IL-10 immune modulation against acute lung injury in mice.	Curcumin	0-8	CD4 antigen	Mus musculus	48-51
32004976-13	2020	IL-17A, MPO-producing neutrophils, and NF-kappaB p65 expression in lungs of CLP mice decreased significantly after pretreatment with curcumin.	Curcumin	133-141	interleukin 17A	Mus musculus	0-6
32004976-13	2020	IL-17A, MPO-producing neutrophils, and NF-kappaB p65 expression in lungs of CLP mice decreased significantly after pretreatment with curcumin.	Curcumin	133-141	myeloperoxidase	Mus musculus	8-11
32004976-19	2020	CONCLUSIONS: Curcumin can reduce the degree of severity of ALI and uncontrolled inflammation through promoting the differentiation of naive CD4 + T cells to CD4+ CD25+ FOXP3+ Tregs.	Curcumin	13-21	CD4 antigen	Mus musculus	140-143
32004976-19	2020	CONCLUSIONS: Curcumin can reduce the degree of severity of ALI and uncontrolled inflammation through promoting the differentiation of naive CD4 + T cells to CD4+ CD25+ FOXP3+ Tregs.	Curcumin	13-21	CD4 antigen	Mus musculus	157-160
32004976-19	2020	CONCLUSIONS: Curcumin can reduce the degree of severity of ALI and uncontrolled inflammation through promoting the differentiation of naive CD4 + T cells to CD4+ CD25+ FOXP3+ Tregs.	Curcumin	13-21	interleukin 2 receptor, alpha chain	Mus musculus	162-166
32073198-8	2020	Curcumin-stimulated tube formation was associated with an increased expression of VEGFR2 and FABP4.	Curcumin	0-8	kinase insert domain receptor	Homo sapiens	82-88
32073198-9	2020	The stimulatory effects of curcumin were inhibited by VEGFR2 (SU5416) and FABP4 (BMS309403) inhibitors.	Curcumin	27-35	kinase insert domain receptor	Homo sapiens	54-60
32346115-1	2020	Curcumin is a naturally occurring p300-histone acetyltransferase (p300-HAT) inhibitor that suppresses cardiomyocyte hypertrophy and the development of heart failure in experimental animal models.	Curcumin	0-8	E1A binding protein p300	Mus musculus	34-64
32346115-1	2020	Curcumin is a naturally occurring p300-histone acetyltransferase (p300-HAT) inhibitor that suppresses cardiomyocyte hypertrophy and the development of heart failure in experimental animal models.	Curcumin	0-8	E1A binding protein p300	Mus musculus	34-38
32346115-4	2020	We synthesised five synthetic curcumin analogues and found that a compound we have named GO-Y030 most strongly inhibited p300-HAT activity.	Curcumin	30-38	E1A binding protein p300	Mus musculus	121-129
32346115-8	2020	A low dose of the synthetic curcumin analogue GO-Y030 effectively inhibits p300-HAT activity and markedly suppresses the development of heart failure in mice.	Curcumin	28-36	E1A binding protein p300	Mus musculus	75-79
32368050-7	2020	Results: The strength of binding interactions between protein ligand complexes gave scores with NS3 protease, NS5A polymerase, and NS5B polymerase of -124.91, -159.02, and -129.16, for curcumin respectively, and -68.51, -54.52, and -157.63 for CuCs nanocomposite, respectively.	Curcumin	185-193	KRAS proto-oncogene, GTPase	Homo sapiens	96-99
32069075-2	2020	In this study, we established hypoxia-reoxygenation in neonate rat myocardial cells and employed gamma-secretase inhibitor and curcumin to inhibit and activate the Notch1 and Keap1-Nrf2 signaling pathways, respectively.	Curcumin	127-135	Kelch-like ECH-associated protein 1	Rattus norvegicus	175-180
32019426-0	2020	Curcumin diminishes cisplatin-induced apoptosis and mitochondrial oxidative stress through inhibition of TRPM2 channel signaling pathway in mouse optic nerve.	Curcumin	0-8	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	105-110
32019426-7	2020	In the patch-clamp of SH-SY5Y cells and laser confocal microscopy experiments of optic nerve, CURCU and TRPM2 blocker treatments also decreased ADPR-induced TRPM2 currents and cytosolic free calcium ion (Ca2+) concentration, suggesting a suppression of Ca2+ influx and neuronal death.Conclusion: CURCU prevents CiSP-induced optic nerve oxidative injury and cell death by suppressing mitochondrial ROS production via regulating TRPM2 signaling pathways.	Curcumin	94-99	transient receptor potential cation channel subfamily M member 2	Homo sapiens	157-162
32019426-7	2020	In the patch-clamp of SH-SY5Y cells and laser confocal microscopy experiments of optic nerve, CURCU and TRPM2 blocker treatments also decreased ADPR-induced TRPM2 currents and cytosolic free calcium ion (Ca2+) concentration, suggesting a suppression of Ca2+ influx and neuronal death.Conclusion: CURCU prevents CiSP-induced optic nerve oxidative injury and cell death by suppressing mitochondrial ROS production via regulating TRPM2 signaling pathways.	Curcumin	94-99	transient receptor potential cation channel subfamily M member 2	Homo sapiens	157-162
32163510-11	2020	Based on the results of this study, the curcumin treatment appeared to exert a protective effect on cartilage, as it did not result in an increase in cartilage thickness or in MMP-8 and MMP-13 expression but led to increased IHH, Col2, and SOX-5 expression and the number of chondrocytes.	Curcumin	40-48	Indian hedgehog signaling molecule	Rattus norvegicus	225-228
32163510-11	2020	Based on the results of this study, the curcumin treatment appeared to exert a protective effect on cartilage, as it did not result in an increase in cartilage thickness or in MMP-8 and MMP-13 expression but led to increased IHH, Col2, and SOX-5 expression and the number of chondrocytes.	Curcumin	40-48	SRY-box transcription factor 5	Rattus norvegicus	240-245
31545905-7	2020	In MCF-7 cells, the following changes were observed: an increase of omega6 linoleic acid in the cells incubated with somatostatin + quercetin and quercetin and a decrease of omega3 acids in the cells incubated with somatostatin + curcumin compared to somatostatin and significant increases of monounsaturated fatty acid (MUFA), mono-trans arachidonic acid levels and docosapentaenoic acid for the cells incubated with somatostatin + quercetin compared to the control cells.	Curcumin	230-238	somatostatin	Homo sapiens	117-129
31981960-0	2020	Dimethyl fumarate and curcumin attenuate hepatic ischemia/reperfusion injury via Nrf2/HO-1 activation and anti-inflammatory properties.	Curcumin	22-30	heme oxygenase 1	Rattus norvegicus	86-90
30345819-1	2020	Licochalcone B (LCB), an extract from the root of Glycyrrhiza inflate, has the same caffeic acid scaffold as curcumin (Cur), which is known as an anti-Alzheimer"s disease (AD) agent.	Curcumin	109-117	clathrin light chain B	Homo sapiens	16-19
30345819-1	2020	Licochalcone B (LCB), an extract from the root of Glycyrrhiza inflate, has the same caffeic acid scaffold as curcumin (Cur), which is known as an anti-Alzheimer"s disease (AD) agent.	Curcumin	119-122	clathrin light chain B	Homo sapiens	16-19
32020216-0	2020	Curcumin induces re-expression of BRCA1 and suppression of gamma synuclein by modulating DNA promoter methylation in breast cancer cell lines.	Curcumin	0-8	BRCA1 DNA repair associated	Homo sapiens	34-39
32020216-4	2020	In the present study, we evaluated the potential of curcumin to re-express hypermethylated BRCA1 and to suppress hypomethylated SNCG in triple-negative breast cancer (TNBC) cell line HCC-38, the estrogen receptor-negative/progesterone receptor-negative (ER-/PR-) cell line UACC-3199, and the ER+/PR+ cell line T47D.	Curcumin	52-60	BRCA1 DNA repair associated	Homo sapiens	91-96
32020216-6	2020	We found that curcumin treatment restored BRCA1 gene expression by reducing the DNA promoter methylation level in HCC-38 and UACC-3199 cells and that it suppressed the expression of SNCG by inducing DNA promoter methylation in T47D cells.	Curcumin	14-22	BRCA1 DNA repair associated	Homo sapiens	42-47
32020216-8	2020	Curcumin-induced hypomethylation of the BRCA1 promoter appears to be realized through the upregulation of the ten-eleven translocation 1 (TET1) gene, whereas curcumin-induced hypermethylation of SNCG may be realized through the upregulation of the DNA methyltransferase 3 (DNMT3) and the downregulation of TET1.	Curcumin	0-8	BRCA1 DNA repair associated	Homo sapiens	40-45
32020216-8	2020	Curcumin-induced hypomethylation of the BRCA1 promoter appears to be realized through the upregulation of the ten-eleven translocation 1 (TET1) gene, whereas curcumin-induced hypermethylation of SNCG may be realized through the upregulation of the DNA methyltransferase 3 (DNMT3) and the downregulation of TET1.	Curcumin	158-166	BRCA1 DNA repair associated	Homo sapiens	40-45
32020216-11	2020	We believe that curcumin may be considered a promising therapeutic option for treating TNBC patients in addition to preventing breast and ovarian cancer, particularly in cancer-free females harboring methylated BRCA1.	Curcumin	16-24	BRCA1 DNA repair associated	Homo sapiens	211-216
32027482-3	2020	The curcumin analog-based nanoscavenger (NanoCA) is engineered capable of controlled-release property to stimulate nuclear translocation of the major autophagy regulator, transcription factor EB (TFEB), triggering both autophagy and calcium-dependent exosome secretion for the clearance of alpha-syn.	Curcumin	4-12	transcription factor EB	Mus musculus	196-200
31858697-3	2020	Previously, we identified a novel TFEB activator named curcumin analog C1 which directly binds to and activates TFEB.	Curcumin	55-63	transcription factor EB	Mus musculus	34-38
31858697-3	2020	Previously, we identified a novel TFEB activator named curcumin analog C1 which directly binds to and activates TFEB.	Curcumin	55-63	transcription factor EB	Mus musculus	112-116
31858697-7	2020	In summary, curcumin analog C1 is a potent TFEB activator with promise for the prevention or treatment of AD.	Curcumin	12-20	transcription factor EB	Mus musculus	43-47
31659616-5	2020	We have been able to demonstrate that curcumin significantly increases oxidative stress and accelerates replicative and chronological aging of yeast cells devoid of anti-oxidative protection (with SOD1 and SOD2 gene deletion) and deprived of DNA repair mechanisms (RAD52).	Curcumin	38-46	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	206-210
31816386-0	2020	Curcumin ameliorates oxidative stress-induced intestinal barrier injury and mitochondrial damage by promoting Parkin dependent mitophagy through AMPK-TFEB signal pathway.	Curcumin	0-8	parkin RBR E3 ubiquitin protein ligase	Sus scrofa	110-116
31816386-6	2020	In this study, we found that curcumin can effectively ameliorate hydrogen peroxide (H2O2)-induced oxidative stress, intestinal epithelial barrier injury and mitochondrial damage in porcine intestinal epithelial cells (IPEC-J2 cells) in a PTEN-induced putative kinase (PINK1)-Parkin mitophagy dependent way.	Curcumin	29-37	parkin RBR E3 ubiquitin protein ligase	Sus scrofa	275-281
31816386-7	2020	Mechanistically, depletion of Parkin (a mitophagy related protein) abolished curcumin"s protective action on anti-oxidative stress, improving intestinal barrier and mitochondrial function in porcine intestinal epithelial cells (IPEC-J2) induced by H2O2.	Curcumin	77-85	parkin RBR E3 ubiquitin protein ligase	Sus scrofa	30-36
31816386-8	2020	Consistently, the protective effect of curcumin was not found in cells transfected with GFP-ParkinDeltaUBL, which encodes a mutant Parkin protein without the ubiquitin E3 ligase activity, indicating that the ubiquitin E3 ligase of Parkin is required for curcumin"s protective effects.	Curcumin	39-47	parkin RBR E3 ubiquitin protein ligase	Sus scrofa	131-137
31656219-8	2020	Also, the expression of GDF-9, BMP-15, SIRT-1 and SIRT-3 genes was increased in the curcumin group.	Curcumin	84-92	bone morphogenetic protein 15	Mus musculus	31-37
32021440-0	2020	Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a.	Curcumin	10-18	thioredoxin reductase 1	Mus musculus	39-44
32673649-14	2020	Curcumin normalized GSH, and NF-kappaB, JNK-Smad3, and TGF-beta-Smad3 pathways, leading to a decrement in activated hepatic stellate cells, thereby producing its antifibrotic effects.	Curcumin	0-8	transforming growth factor alpha	Rattus norvegicus	55-63
30332967-3	2020	MATERIALS AND METHOD: Curcumin and its analogues were subjected to docking using PDE4A, PDE4B, PDE4C and PDE4D as the target.	Curcumin	22-30	phosphodiesterase 4D	Homo sapiens	105-110
31991296-0	2020	The effects of curcumin supplementation on oxidative stress, Sirtuin-1 and peroxisome proliferator activated receptor gamma coactivator 1alpha gene expression in polycystic ovarian syndrome (PCOS) patients: A randomized placebo-controlled clinical trial.	Curcumin	15-23	sirtuin 1	Homo sapiens	61-142
31991296-2	2020	The aim in this trial was to evaluate the efficacy of curcumin supplementation on oxidative stress enzymes, sirtuin-1 (SIRT1) and Peroxisome proliferator activated receptor gamma coactivator 1alpha (PGC1alpha) gene expression in PCOS patients.	Curcumin	54-62	sirtuin 1	Homo sapiens	108-117
31991296-2	2020	The aim in this trial was to evaluate the efficacy of curcumin supplementation on oxidative stress enzymes, sirtuin-1 (SIRT1) and Peroxisome proliferator activated receptor gamma coactivator 1alpha (PGC1alpha) gene expression in PCOS patients.	Curcumin	54-62	sirtuin 1	Homo sapiens	119-124
31991296-8	2020	Curcumin also non-significantly increased gene expression of SIRT1 and activity of the SOD enzyme.	Curcumin	0-8	sirtuin 1	Homo sapiens	61-66
31025894-8	2020	After supplementation, curcumin significantly blunted CK levels (199.62 U/L) compared to the placebo (287.03 U/L), overall (p < 0.0001).	Curcumin	23-31	cytidine/uridine monophosphate kinase 1	Homo sapiens	54-56
31526948-7	2020	The cytotoxic effect of curcumin in cervical cancer cells was related to the complex p53-NQO1 that avoids the interaction between p53 and its negative regulator ubiquitin ligase E6-associated protein (E6AP).	Curcumin	24-32	ubiquitin protein ligase E3A	Homo sapiens	178-199
31526948-7	2020	The cytotoxic effect of curcumin in cervical cancer cells was related to the complex p53-NQO1 that avoids the interaction between p53 and its negative regulator ubiquitin ligase E6-associated protein (E6AP).	Curcumin	24-32	ubiquitin protein ligase E3A	Homo sapiens	201-205
33124505-15	2020	Curcumin inhibits NSCLC migration and invasion by suppressing radiation-induced EMT and sE-cad expression by decreasing MMP9 expression.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	120-124
31888111-4	2019	Most importantly, the role of natural antioxidants, i.e., curcumin, melatonin and Mg2+, in preventing detrimental oxidant effects on B3p is considered.	Curcumin	58-66	immunoglobulin kappa variable 4-1	Homo sapiens	133-136
31773117-0	2019	Curcumin inhibits cigarette smoke-induced inflammation via modulating the PPARgamma-NF-kappaB signaling pathway.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	74-83
31773117-4	2019	The purpose of this study was to validate the relationship between PPARgamma and NF-kappaB in cigarette smoke (CS)-induced COPD models, and then to investigate whether the therapeutic effect of curcumin on COPD is achieved through modulating the PPARgamma-NF-kappaB signaling pathway.	Curcumin	194-202	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	246-255
31773117-6	2019	Importantly, we found that the inhibitory effect on NF-kappaB by curcumin was dependent on PPARgamma in T0070907-treated or PPARgamma shRNA-transfected Beas-2B cells, indicating that curcumin inhibited CSE-induced inflammation partially through modulating the PPARgamma-NF-kappaB pathway.	Curcumin	65-73	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	124-133
31675556-0	2019	Curcumin functions as a MEK inhibitor to induce a synthetic lethal effect on KRAS mutant colorectal cancer cells receiving targeted drug regorafenib.	Curcumin	0-8	KRAS proto-oncogene, GTPase	Homo sapiens	77-81
31789237-12	2019	Hens in all curcumin treatment groups had slightly (but non-significantly) higher activities of CAT, SOD, GSH-Px, and T-AOC in liver, heart, and lung tissues, compared to heat stressed control group.	Curcumin	12-20	catalase	Gallus gallus	96-99
31485636-10	2019	It was also observed that curcumin treatment downregulated the expression levels of TXNIP, NLRP3, interleukin (IL)-1beta and IL-18, and downstream caspase-1 compared with PQ treatment alone.	Curcumin	26-34	interleukin 18	Homo sapiens	125-130
31421247-14	2019	The SCI-hyperglycemia-curcumin group showed a decrease in glial fibrillary acidic protein expression after SCI compared with the SCI-hyperglycemia group.	Curcumin	22-30	glial fibrillary acidic protein	Rattus norvegicus	58-89
31451010-7	2019	Moreover, curcumin (AP-1 inhibitor) restrained M.tb-induced CTGF expression.	Curcumin	10-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-24
31762728-12	2019	Curcumin upregulated the expression of PGC-1alpha, NRF1, and Mn-SOD, and downregulated the expression of GRP78, PERK, and IRE1alpha in hepatic tissue.	Curcumin	0-8	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	112-116
31564569-9	2019	Curcumin, Quercetin and Withaferin A are known to inhibit multiple molecular pathways that are involved in RAGE signaling.	Curcumin	0-8	advanced glycosylation end-product specific receptor	Homo sapiens	107-111
31651733-3	2019	We hypothesized that SIRT1 expression is decreased in proinflammatory lymphocytes following lung transplant and that treatment with SIRT1 activators (resveratrol, curcumin) and agents that prevent NAD depletion (theophylline) upregulate SIRT1 and reduce proinflammatory cytokine expression in these cells.	Curcumin	163-171	sirtuin 1	Homo sapiens	21-26
31651733-3	2019	We hypothesized that SIRT1 expression is decreased in proinflammatory lymphocytes following lung transplant and that treatment with SIRT1 activators (resveratrol, curcumin) and agents that prevent NAD depletion (theophylline) upregulate SIRT1 and reduce proinflammatory cytokine expression in these cells.	Curcumin	163-171	sirtuin 1	Homo sapiens	132-137
31651733-3	2019	We hypothesized that SIRT1 expression is decreased in proinflammatory lymphocytes following lung transplant and that treatment with SIRT1 activators (resveratrol, curcumin) and agents that prevent NAD depletion (theophylline) upregulate SIRT1 and reduce proinflammatory cytokine expression in these cells.	Curcumin	163-171	sirtuin 1	Homo sapiens	132-137
32239852-1	2019	OBJECTIVE: To study the mechanisms of curcumin alleviating oxidative stress and spleen apoptosis induced by overtraining in rats by regulating Kelch-like ECH-associated protein-1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) signaling pathway.	Curcumin	38-46	Kelch-like ECH-associated protein 1	Rattus norvegicus	143-178
32239852-1	2019	OBJECTIVE: To study the mechanisms of curcumin alleviating oxidative stress and spleen apoptosis induced by overtraining in rats by regulating Kelch-like ECH-associated protein-1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) signaling pathway.	Curcumin	38-46	Kelch-like ECH-associated protein 1	Rattus norvegicus	180-185
32239852-12	2019	Curcumin can up-regulate expression of Nrf2 and HO-1, alleviate oxidative stress induced by overtraining, enhance Bcl-2 expression and attenuate Bax expression, thereby inhibiting excessive spleen apoptosis of rats, protecting the structure and function of spleen.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	48-52
31666589-9	2019	Additionally, curcumin attenuated blood sugar in S961-treated C57BL/6 mice and in diet-induced diabetic ICR mice and long-term regulate HbA1c in diabetic mice.	Curcumin	14-22	hemoglobin alpha, adult chain 1	Mus musculus	136-140
31656916-0	2019	Resveratrol and Curcumin Improve Intestinal Mucosal Integrity and Decrease m6A RNA Methylation in the Intestine of Weaning Piglets.	Curcumin	16-24	glycoprotein M6A	Homo sapiens	75-78
31656916-2	2019	Resveratrol and curcumin, which can exert many health-protective effects, may have a relationship with m6A RNA methylation.	Curcumin	16-24	glycoprotein M6A	Homo sapiens	103-106
31656916-3	2019	We hypothesized that the combination of resveratrol and curcumin could affect growth performance, intestinal mucosal integrity, m6A RNA methylation, and gene expression in weaning piglets.	Curcumin	56-64	glycoprotein M6A	Homo sapiens	128-131
31656916-7	2019	Furthermore, resveratrol and curcumin decreased the content of m6A and decreased the enrichment of m6A on the transcripts of tight junction proteins and on heme oxygenase-1 in the intestine.	Curcumin	29-37	glycoprotein M6A	Homo sapiens	63-66
31656916-7	2019	Furthermore, resveratrol and curcumin decreased the content of m6A and decreased the enrichment of m6A on the transcripts of tight junction proteins and on heme oxygenase-1 in the intestine.	Curcumin	29-37	glycoprotein M6A	Homo sapiens	99-102
31656916-8	2019	Our findings indicated that the combination of resveratrol and curcumin increased growth performance, enhanced intestine function, and protected piglet health, which may be associated with changes in m6A methylation and gene expression, suggesting that curcumin and resveratrol may be a potential natural alternative to antibiotics.	Curcumin	63-71	glycoprotein M6A	Homo sapiens	200-203
31656916-8	2019	Our findings indicated that the combination of resveratrol and curcumin increased growth performance, enhanced intestine function, and protected piglet health, which may be associated with changes in m6A methylation and gene expression, suggesting that curcumin and resveratrol may be a potential natural alternative to antibiotics.	Curcumin	253-261	glycoprotein M6A	Homo sapiens	200-203
31593984-5	2019	Results: Treatment with curcumin resulted in a dose- and time-dependent decrease in IL-1beta-induced synthesis of inflammatory cytokines, including IL-6, IL-8, MCP-1, and ICAM-1 at both mRNA and protein levels.	Curcumin	24-32	intercellular adhesion molecule 1	Homo sapiens	171-177
31539917-5	2019	Under the same experimental conditions, the reference MAO inhibitor, curcumin, displays IC50 values of 5.01 microM and 2.55 microM for the inhibition of MAO-A and MAO-B, respectively.	Curcumin	69-77	monoamine oxidase B	Homo sapiens	163-168
31136038-4	2019	Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer.	Curcumin	0-8	heat shock protein family D (Hsp60) member 1	Homo sapiens	86-91
31136038-4	2019	Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer.	Curcumin	0-8	heat shock protein family A (Hsp70) member 4	Homo sapiens	93-98
31405268-9	2019	Cell death was decreased by inhibiting curcumin-induced autophagy using small interference RNA (siRNA) of Atg5 or Beclin1.	Curcumin	39-47	beclin 1	Homo sapiens	114-121
31279955-0	2019	Short-term curcumin supplementation enhances serum brain-derived neurotrophic factor in adult men and women: a systematic review and dose-response meta-analysis of randomized controlled trials.	Curcumin	11-19	brain derived neurotrophic factor	Homo sapiens	51-84
31279955-2	2019	Several randomized controlled trials have examined the neuroprotective effects of curcumin and its ability to increase BDNF levels, with inconclusive results.	Curcumin	82-90	brain derived neurotrophic factor	Homo sapiens	119-123
31279955-3	2019	The aim of this systematic review was to evaluate the impact of curcumin supplementation on serum BDNF levels.	Curcumin	64-72	brain derived neurotrophic factor	Homo sapiens	98-102
31279955-5	2019	The studies included were randomized control trials of curcumin supplementation that reported the serum BDNF level as a primary outcome.	Curcumin	55-63	brain derived neurotrophic factor	Homo sapiens	104-108
31279955-9	2019	Curcumin supplementation significantly increased serum BDNF levels (weighted mean difference: 1789.38 pg/mL, 95% confidence interval: 722.04-2856.71, P < .01) with significant heterogeneity among the studies (I2 = 83.5%, P < .001).	Curcumin	0-8	brain derived neurotrophic factor	Homo sapiens	55-59
31279955-11	2019	The significant positive impact of curcumin supplementation on BDNF levels indicates its potential use for neurological disorders that are associated with low BDNF levels.	Curcumin	35-43	brain derived neurotrophic factor	Homo sapiens	63-67
31279955-11	2019	The significant positive impact of curcumin supplementation on BDNF levels indicates its potential use for neurological disorders that are associated with low BDNF levels.	Curcumin	35-43	brain derived neurotrophic factor	Homo sapiens	159-163
31511210-6	2019	In the two glioma cell lines, curcumin significantly suppressed the invasion and migration of the cells (P &amp;lt; 0.05) and lowered the expressions of hepatoma-derived growth factor (HDGF), Ncadherin, vimentin, Snail and Slug, but increased the expression of E-cadherin.	Curcumin	30-38	cadherin 2	Homo sapiens	192-201
31511210-6	2019	In the two glioma cell lines, curcumin significantly suppressed the invasion and migration of the cells (P &amp;lt; 0.05) and lowered the expressions of hepatoma-derived growth factor (HDGF), Ncadherin, vimentin, Snail and Slug, but increased the expression of E-cadherin.	Curcumin	30-38	snail family transcriptional repressor 2	Homo sapiens	223-227
31455356-9	2019	Intraperitoneal administration of curcumin alleviated MSU crystal-induced paw and ankle joint swelling, inflammatory cell infiltration, and MPO activity in mouse models of acute gout.	Curcumin	34-42	myeloperoxidase	Mus musculus	140-143
31455864-0	2019	Albumin evokes Ca2+-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin.	Curcumin	128-136	transient receptor potential cation channel subfamily M member 2	Homo sapiens	72-77
31455864-7	2019	Curcumin accumulates in plasma membrane and intracellular vesicles, where it interferes with TRPM2 and decreases the influx of Ca2+.	Curcumin	0-8	transient receptor potential cation channel subfamily M member 2	Homo sapiens	93-98
31455864-9	2019	Albumin-induced cell stress is diminished by the inhibition of TRPM2 after administration of curcumin and ADPR (PARP1) inhibitors.	Curcumin	93-101	transient receptor potential cation channel subfamily M member 2	Homo sapiens	63-68
31497553-4	2019	Methods: To evaluate their putative activity, curcumin and resveratrol compounds were administered alone or in combination on the media culture of cAMP EPAC (exchange protein directly activated by cAMP) bioluminescence resonance energy transfer (BRET) biosensor.	Curcumin	46-54	Rap guanine nucleotide exchange factor 3	Homo sapiens	152-156
30859861-5	2019	Curcumin attenuated PA-induced reduction in cell viability and activation of apoptosis, Caspase 3 activity, BAX, CHOP, and GRP78 expression.	Curcumin	0-8	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	123-128
30859861-7	2019	Both curcumin and 4-PBA also attenuated PA-induced increase in ER stress protein (CHOP and GRP78) expression.	Curcumin	5-13	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	91-96
31059026-0	2019	Curcumin reverses doxorubicin resistance via inhibition the efflux function of ABCB4 in doxorubicin-resistant breast cancer cells.	Curcumin	0-8	ATP binding cassette subfamily B member 4	Homo sapiens	79-84
31059026-7	2019	The intracellular accumulation of doxorubicin was substantially increased following curcumin treatment in doxorubicin-resistant breast cancer cells, in a manner that was inversely dependent on the activity of ATP binding cassette subfamily B member 4 (ABCB4).	Curcumin	84-92	ATP binding cassette subfamily B member 4	Homo sapiens	209-250
31059026-7	2019	The intracellular accumulation of doxorubicin was substantially increased following curcumin treatment in doxorubicin-resistant breast cancer cells, in a manner that was inversely dependent on the activity of ATP binding cassette subfamily B member 4 (ABCB4).	Curcumin	84-92	ATP binding cassette subfamily B member 4	Homo sapiens	252-257
31059026-8	2019	Treatment with a combination of curcumin and doxorubicin decreases the efflux of doxorubicin in ABCB4-overexpressing cells.	Curcumin	32-40	ATP binding cassette subfamily B member 4	Homo sapiens	96-101
31059026-9	2019	Furthermore, curcumin inhibited the ATPase activity of ABCB4 without altering its protein expression.	Curcumin	13-21	ATP binding cassette subfamily B member 4	Homo sapiens	55-60
31059026-10	2019	In conclusion, curcumin reversed doxorubicin resistance in human breast cancer MCF-7/DOX and MDA-MB-231/DOX cells by inhibiting the ATPase activity of ABCB4.	Curcumin	15-23	ATP binding cassette subfamily B member 4	Homo sapiens	151-156
32454710-0	2019	Decreased Protein Kinase C Expression in the Cochlear Fibroblasts of Diabetic Rat Models Induced by Curcumin.	Curcumin	100-108	protein kinase C, gamma	Rattus norvegicus	10-26
32454710-4	2019	Curcumin as an antioxidant also affects the regulation of PKC and Ca2+.	Curcumin	0-8	protein kinase C, gamma	Rattus norvegicus	58-61
32454710-5	2019	The aim of this study was to determine the role of curcumin in decreasing PKC expression in the cochlear fibroblasts of diabetic rats.	Curcumin	51-59	protein kinase C, gamma	Rattus norvegicus	74-77
32454710-10	2019	Conclusion: Curcumin can reduce PKC expression in the cochlear fibroblasts of diabetic rats.	Curcumin	12-20	protein kinase C, gamma	Rattus norvegicus	32-35
31141941-3	2019	We examined the effects of natural bioactive materials including Resveratrol (RSV), thymoquinone (TQ) and curcumin on the expression of TTP in cancer cell.	Curcumin	106-114	zinc finger protein 36	Mus musculus	136-139
31112588-0	2019	Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway.	Curcumin	0-8	kelch-like ECH-associated protein 1	Mus musculus	129-134
31112588-8	2019	The effect of curcumin on Nrf2-Keap1 signaling pathway-related genes was analyzed by qRT-PCR.	Curcumin	14-22	kelch-like ECH-associated protein 1	Mus musculus	31-36
31112588-15	2019	The middle-dose curcumin-treated group also exhibited enhanced expression of glutamate-cysteine ligase, a modifier subunit (GLCM), but inhibited transcription of glutamate-cysteine ligase, a catalytic subunit (GCLC).	Curcumin	16-24	glutamate-cysteine ligase, catalytic subunit	Mus musculus	210-214
31112588-16	2019	Curcumin resisted oxidants by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway, which could potentially promote cell survival.	Curcumin	0-8	kelch-like ECH-associated protein 1	Mus musculus	101-106
31092832-0	2019	Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFkB/AKT/mTOR/KEAP1 signalling in rat heart.	Curcumin	41-49	mechanistic target of rapamycin kinase	Rattus norvegicus	120-124
31092832-0	2019	Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFkB/AKT/mTOR/KEAP1 signalling in rat heart.	Curcumin	41-49	Kelch-like ECH-associated protein 1	Rattus norvegicus	125-130
31092832-7	2019	Co-administration of vitamin E and curcumin showed better result in attenuating expression of mammalian target for rapamycin (mTOR), restoration of total protein content and biological activity of Ca2+ ATPase in hyperthyroid rats, whereas, their individual treatment showed partial restoration.	Curcumin	35-43	carbonic anhydrase 2	Homo sapiens	197-208
31092832-10	2019	Further, curcumin and vitamin E complex showed in silico interaction with KEAP1.	Curcumin	9-17	Kelch-like ECH-associated protein 1	Rattus norvegicus	74-79
31092832-11	2019	Reduction of oxidative stress by curcumin and/or vitamin E may be due to modulation of NRF2 and KEAP1 function in rat heart under altered thyroid states.	Curcumin	33-41	Kelch-like ECH-associated protein 1	Rattus norvegicus	96-101
31091659-10	2019	Modeling of mTOR protein revealed structural changes upon treatments, and curcumin plus GR decreased binding of Raptor and GbetaL to mTOR, as well as of Rag A and Rag B to Raptor.	Curcumin	74-82	Ras related GTP binding B	Homo sapiens	163-168
30394523-1	2019	BACKGROUND: CMC2.24, a novel tri-ketonic chemically modified compound based on natural di-ketonic curcumin, has been shown to reduce bone loss and inflammatory mediators in experimental periodontitis, however, a potential dose-response relationship was not determined.	Curcumin	98-106	C-X9-C motif containing 2	Homo sapiens	12-16
31080349-6	2019	Moreover, the increased apoB RNA editing by 50 microM curcumin was significantly reduced by siRNA-mediated APOBEC-1, ACF, and RBM47 knockdown.	Curcumin	54-62	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	Mus musculus	107-115
31080349-6	2019	Moreover, the increased apoB RNA editing by 50 microM curcumin was significantly reduced by siRNA-mediated APOBEC-1, ACF, and RBM47 knockdown.	Curcumin	54-62	RNA binding motif protein 47	Mus musculus	126-131
31551208-6	2019	The expression levels of COX-2 and MMP-9 were both down-regulated by curcumin.	Curcumin	69-77	matrix metallopeptidase 9	Homo sapiens	35-40
31061679-3	2019	The purpose of this study was to investigate if yoghurt enriched with curcumin and metformin, individually or as mixtures, ameliorates physiometabolic parameters, glycoxidative stress biomarkers, and paraoxonase 1 (PON 1) activity in diabetic rats.	Curcumin	70-78	paraoxonase 1	Rattus norvegicus	200-213
31061679-3	2019	The purpose of this study was to investigate if yoghurt enriched with curcumin and metformin, individually or as mixtures, ameliorates physiometabolic parameters, glycoxidative stress biomarkers, and paraoxonase 1 (PON 1) activity in diabetic rats.	Curcumin	70-78	paraoxonase 1	Rattus norvegicus	215-220
31040648-2	2019	In the present study, whether curcumin exerts neuroprotective effects associated with the inhibition of autophagy and hypoxia inducible factor-1alpha (HIF-1alpha) was investigated.	Curcumin	30-38	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	118-149
31040648-10	2019	Results: In this study, curcumin decreased the death and apoptosis of cells, and inhibited autophagy and HIF-1alpha under OGD/R conditions, consistent with 3-MA treatment or HIF-1alpha downregulation.	Curcumin	24-32	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	105-115
31040648-10	2019	Results: In this study, curcumin decreased the death and apoptosis of cells, and inhibited autophagy and HIF-1alpha under OGD/R conditions, consistent with 3-MA treatment or HIF-1alpha downregulation.	Curcumin	24-32	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	174-184
31040648-12	2019	Conclusion: The results of this study showed that curcumin exerts neuroprotective effects against ischemia-reperfusion, which is associated with the regulation of the reciprocal function between autophagy and HIF-1alpha.	Curcumin	50-58	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	209-219
30798129-4	2019	A curcumin (CUR) and U11-DOX co-encapsulated NPs system (U11-DOX/CUR NPs) was constructed to treat lung cancer.	Curcumin	2-10	RNA, U11 small nuclear	Homo sapiens	57-60
30592318-9	2019	Western blot analysis and QPCR results revealed that curcumin regulated the production of these cytokines by suppressing the expression of inflammasome key components, including NLRP3, caspase-1.	Curcumin	53-61	caspase 1	Rattus norvegicus	185-194
30592318-12	2019	Western blot analysis revealed that the levels of NLRP3, procaspase-1, caspase-1, pro-IL-1beta, and IL-1beta were downregulated by curcumin in vivo.	Curcumin	131-139	caspase 1	Rattus norvegicus	60-69
30717973-7	2019	Moreover, we found that curcumin could regulate XIST/miR-106b-5p/P21 axis in RCC cells.	Curcumin	24-32	microRNA 106b	Homo sapiens	53-61
30668434-9	2019	Our results also supported the involvement of p53-p21 axis in the anticancer effects of curcumin and PTX.	Curcumin	88-96	KRAS proto-oncogene, GTPase	Rattus norvegicus	50-53
30346064-4	2019	In short-term experiments, the combination of UA + Curc given topically prior to 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited activation of epidermal EGFR, p70S6K, NF-kappaB p50, Src, c-Jun, Rb, and IkappaBalpha.	Curcumin	51-55	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	178-184
30551471-0	2019	Curcumin augments the cardioprotective effect of metformin in an experimental model of type I diabetes mellitus; Impact of Nrf2/HO-1 and JAK/STAT pathways.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	128-140
30551471-10	2019	Inhibition of JAK/STAT pathway and activation of Nrf2/HO-1 pathway seems to be among the mechanisms mediating the effects of curcumin and metformin.	Curcumin	125-133	heme oxygenase 1	Rattus norvegicus	54-58
30621501-13	2019	Curcumin liposome decreased the expressions of MVD and VEGF and increased the apoptosis of liver tissues.	Curcumin	0-8	vascular endothelial growth factor A	Oryctolagus cuniculus	55-59
30395942-4	2019	The non-cytotoxic dose (IC20 values) of curcumin (WT1 and AP-1 inhibitors) was employed to examine its effect on WT1 gene-mediated WT1 and AP-1 protein expression.	Curcumin	40-48	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-62
30395942-4	2019	The non-cytotoxic dose (IC20 values) of curcumin (WT1 and AP-1 inhibitors) was employed to examine its effect on WT1 gene-mediated WT1 and AP-1 protein expression.	Curcumin	40-48	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	139-143
30395942-7	2019	A ChIP assay showed that curcumin and tanshinone IIA inhibited AP-1 and WT1 binding to the proximal WT1 promoter (-301 bp), and a luciferase reporter assay showed that the WT1 luciferase gene reporter activity was decreased after curcumin, tanshinone IIA, and SP600126 treatments.	Curcumin	25-33	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-67
30747066-7	2019	Curcumin also showed anti-cancer effects in a xenograft mouse model and reduced EZH2, H3K4me3 and H3K27me3 in vivo.	Curcumin	0-8	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	80-84
30747066-8	2019	EZH2 knockdown can reduce the H3K27me3 levels and induce curcumin resistance in vitro but attenuates leukemic transformation in vivo.	Curcumin	57-65	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-4
31266378-0	2019	Curcumin inhibits the lymphangiogenesis of gastric cancer cells by inhibiton of HMGB1/VEGF-D signaling.	Curcumin	0-8	vascular endothelial growth factor D	Homo sapiens	86-92
31266378-5	2019	The effects of curcumin on HMGB1 and VEGF-D expression were examined by reverse transcription polymerase chain reaction (RT-PCR) and western blot analysis.	Curcumin	15-23	vascular endothelial growth factor D	Homo sapiens	37-43
31266378-7	2019	The mRNA and protein expression levels of HMGB1 and VEGF-D were significantly eliminated by curcumin administration.	Curcumin	92-100	vascular endothelial growth factor D	Homo sapiens	52-58
31266378-8	2019	Pre-treatment with the recombinant HMGB1 (rHMGB1) markedly abolished curcumin-reduced VEGF-D expression.	Curcumin	69-77	high mobility group box 1	Rattus norvegicus	42-48
31266378-8	2019	Pre-treatment with the recombinant HMGB1 (rHMGB1) markedly abolished curcumin-reduced VEGF-D expression.	Curcumin	69-77	vascular endothelial growth factor D	Homo sapiens	86-92
31266378-9	2019	Our findings suggested that curcumin might exert anti-lymphangiogenesis in gastric cancer by inhibition of HMGB1/VEGF-D signaling.	Curcumin	28-36	vascular endothelial growth factor D	Homo sapiens	113-119
30276838-2	2019	Curcumin, is a compound isolated from Curcuma longa, has been reported to inhibit drug efflux in several human cell lines and nonpathogenic budding yeast Saccharomyces cerevisiae cells that overexpresses the ATP-binding cassette (ABC) transporters S. cerevisiae Pdr5p and pathogenic Candida albicans Cdr1p and Cdr2p.	Curcumin	0-8	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	262-267
30276838-6	2019	Reverse transcription-polymerase chain reaction analysis revealed that curcumin reduced the dodecanol-induced overexpression of the ABC transporter-related genes PDR1, PDR3 and PDR5 to their control levels in untreated cells.	Curcumin	71-79	drug-responsive transcription factor PDR3	Saccharomyces cerevisiae S288C	168-172
30276838-6	2019	Reverse transcription-polymerase chain reaction analysis revealed that curcumin reduced the dodecanol-induced overexpression of the ABC transporter-related genes PDR1, PDR3 and PDR5 to their control levels in untreated cells.	Curcumin	71-79	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	177-181
30276838-7	2019	Curcumin can directly restrict the glucose-induced drug efflux and inhibits the expression of the ABC transporter gene PDR5, and can thereby inhibit the efflux of dodecanol from S. cerevisiae cells.	Curcumin	0-8	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	119-123
30276838-10	2019	Curcumin, isolated from Curcuma longa, inhibits drug efflux in nonpathogenic budding yeast Saccharomyces cerevisiae cells overexpressing ABC transporters S. cerevisiae Pdr5p and pathogenic Candida albicans Cdr1p and Cdr2p.	Curcumin	0-8	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	168-173
30276838-12	2019	Curcumin directly inhibited drug efflux and also suppressed the PDR5 expression, thereby enhancing the antifungal effects.	Curcumin	0-8	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	64-68
30599093-9	2019	Additionally, the cholesterol transmembrane regulators ABCA1, ABCG1, and CAV1 were enhanced by curcumin in vivo.	Curcumin	95-103	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	55-60
30943499-11	2019	The protein levels of c-Fos and NGF were decreased by treatment with curcumin compared with the corresponding protein levels in the BPA group.	Curcumin	69-77	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	22-27
30943499-12	2019	Besides, curcumin reduced the number of GFAP positive cells and GFAP expression.	Curcumin	9-17	glial fibrillary acidic protein	Rattus norvegicus	40-44
30943499-12	2019	Besides, curcumin reduced the number of GFAP positive cells and GFAP expression.	Curcumin	9-17	glial fibrillary acidic protein	Rattus norvegicus	64-68
30172816-0	2018	Effective suppression of the modified PHF6 peptide/1N4R Tau amyloid aggregation by intact curcumin, not its degradation products: Another evidence for the pigment as preventive/therapeutic "functional food".	Curcumin	90-98	PHD finger protein 6	Homo sapiens	38-42
30172816-2	2018	In present study, the influence of curcumin and its degradation products (DPs) on the amyloid aggregation of Tau protein and the related PHF6 peptide were investigated.	Curcumin	35-43	PHD finger protein 6	Homo sapiens	137-141
30145851-3	2018	Curcumin possesses both antioxidant and anti-inflammatory properties and has been shown to increase sirtuin-1 (SIRT1) by activating small molecules.	Curcumin	0-8	sirtuin 1	Homo sapiens	100-109
30145851-3	2018	Curcumin possesses both antioxidant and anti-inflammatory properties and has been shown to increase sirtuin-1 (SIRT1) by activating small molecules.	Curcumin	0-8	sirtuin 1	Homo sapiens	111-116
30145851-4	2018	Upregulation of SIRT1 by curcumin has been reported to confer protective effects against a range of neurological disorders including glutamate excitotoxicity, beta-amyloid-induced cell death in cortical neurons, cerebral ischemic damage, and stroke.	Curcumin	25-33	sirtuin 1	Homo sapiens	16-21
30145851-5	2018	Activation of AMPK and SIRT1 by curcumin has also been noted to mediate the protective effects of curcumin against ischemia/reperfusion injury, cardiac fibrosis, diabetes, and lipid metabolism abnormalities.	Curcumin	32-40	sirtuin 1	Homo sapiens	23-28
30145851-5	2018	Activation of AMPK and SIRT1 by curcumin has also been noted to mediate the protective effects of curcumin against ischemia/reperfusion injury, cardiac fibrosis, diabetes, and lipid metabolism abnormalities.	Curcumin	98-106	sirtuin 1	Homo sapiens	23-28
30145851-7	2018	In this review, we summarize the role of SIRT1 in mediating the pharmacological effects of curcumin in several diseases.	Curcumin	91-99	sirtuin 1	Homo sapiens	41-46
30396035-10	2018	Mechanistically, curcumin prevented DSS-induced K+ efflux, intracellular ROS formation and cathepsin B release, three major cellular events mediating NLRP3 inflammasome activation.	Curcumin	17-25	cathepsin B	Mus musculus	91-102
30396035-12	2018	Meanwhile, curcumin significantly decreased the expression of multiple inflammatory cytokines (including mature IL-1beta, IL-6, MCP-1), MPO activity, caspase-1 activity as well as histopathological damage.	Curcumin	11-19	myeloperoxidase	Mus musculus	136-139
30371703-2	2018	An MMP-2-responsive peptide, PVGLIG, was used to endow the polymeric prodrug with the ability to rapidly release the anti-inflammatory drug, curcumin (CUR), after the targeted site is reached and to improve the drug concentration in the target tissue.	Curcumin	141-149	matrix metallopeptidase 2	Mus musculus	3-8
30468499-0	2018	Curcumin alleviates isoproterenol-induced cardiac hypertrophy and fibrosis through inhibition of autophagy and activation of mTOR.	Curcumin	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	125-129
30468499-13	2018	Curcumin abolished these isoprenaline-mediated changes in mTOR/autophagy signaling pathway.	Curcumin	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	58-62
30468499-14	2018	CONCLUSIONS: Our data demonstrated that curcumin targeted mTOR/autophagy axis could attenuate cardiac hypertrophy and fibrosis in a rat model.	Curcumin	40-48	mechanistic target of rapamycin kinase	Rattus norvegicus	58-62
30292723-6	2018	Curcumin activated AMPK and JNK1, which phosphorylated Bcl-2 and Bim and subsequently disrupted their interactions with Beclin1, thereby promoting autophagy and alleviating apoptosis respectively.	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	28-32
30405819-6	2018	It was determined that curcumin decreased the tumor weight and size, downregulated the expression of Notch and HIF-1 mRNA and suppressed the VEGF and NF-kappaB expression.	Curcumin	23-31	vascular endothelial growth factor A	Mus musculus	141-145
30405819-7	2018	These results indicated that curcumin inhibited lung cancer growth through the regulation of angiogenesis mediated by VEGF signaling.	Curcumin	29-37	vascular endothelial growth factor A	Mus musculus	118-122
30741618-8	2018	Our findings showed the protective effect of Curcumin in I/R injury is associated with suppressing NF-kappaB mediating inflammation by activating JAK2/STAT3 signal pathway.	Curcumin	45-53	Janus kinase 2	Rattus norvegicus	146-150
30356017-0	2018	HSP70 Acetylation Prevents Combined mTORC1/2 Inhibitor and Curcumin Treatment-Induced Apoptosis.	Curcumin	59-67	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
30356017-6	2018	Furthermore, overexpression of HSP70 significantly inhibited PP242 plus curcumin-induced LMP and apoptosis, but the protective effect was abolished by K77R mutation of acetylation site of HSP70.	Curcumin	72-80	heat shock protein family A (Hsp70) member 4	Homo sapiens	31-36
30356017-6	2018	Furthermore, overexpression of HSP70 significantly inhibited PP242 plus curcumin-induced LMP and apoptosis, but the protective effect was abolished by K77R mutation of acetylation site of HSP70.	Curcumin	72-80	heat shock protein family A (Hsp70) member 4	Homo sapiens	188-193
30356017-7	2018	Taken together, our results reveal that regulation of HSP70 through K77 acetylation plays role in combined PP242 and curcumin treatment-induced apoptosis.	Curcumin	117-125	heat shock protein family A (Hsp70) member 4	Homo sapiens	54-59
30356017-7	2018	Taken together, our results reveal that regulation of HSP70 through K77 acetylation plays role in combined PP242 and curcumin treatment-induced apoptosis.	Curcumin	117-125	keratin 77	Homo sapiens	68-71
30304866-9	2018	The complex paradigm will be discussed within the context of if/how dietary components, nutrients including fatty acids and non-nutrient food components, such as resveratrol, berberine, curcumin and the flavonoid genistein, modulate AMPK dependent processes relating to inflammation and metabolism.	Curcumin	186-194	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	233-237
30327711-9	2018	The serum bilirubin and vascular, liver, and spleen HO-1 mRNA levels were significantly increased in curcumin-treated rabbits.	Curcumin	101-109	heme oxygenase 1	Oryctolagus cuniculus	52-56
30327711-11	2018	Treatment of the rabbits with an inhibitor of HO or HO-1 siRNA to knock down the carotid artery HO-1 abolished the ability of curcumin to inhibit vascular inflammation.	Curcumin	126-134	heme oxygenase 1	Oryctolagus cuniculus	52-56
30327711-11	2018	Treatment of the rabbits with an inhibitor of HO or HO-1 siRNA to knock down the carotid artery HO-1 abolished the ability of curcumin to inhibit vascular inflammation.	Curcumin	126-134	heme oxygenase 1	Oryctolagus cuniculus	96-100
30327711-13	2018	In conclusion, curcumin inhibits vascular inflammation in vivo and in vitro through the activation of HO-1.	Curcumin	15-23	heme oxygenase 1	Oryctolagus cuniculus	102-106
32002947-10	2018	The findings also suggested curcumin"s potential in protecting HT22 cells against acrolein through regulating the BDNF/TrkB signaling.	Curcumin	28-36	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	119-123
30193614-3	2018	Also,curcumin regulates autophagy in tumor cells via signaling pathways including AMP-activated protein kinase,mammalian target of rapamycin,transcription factor EB,Beclin-1,B-cell lymphoma 2,and endoplasmic reticulum stress.	Curcumin	5-13	beclin 1	Homo sapiens	165-173
29887570-6	2018	On the contrary, the real-time PCR results showed that curcumin suppressed 8-br-cAMP-induced expression of Nr5a1 and Fos, which are crucial for cAMP-stimulated StAR and Cyp11a1 expression in Leydig cells.	Curcumin	55-63	nuclear receptor subfamily 5, group A, member 1	Mus musculus	107-112
29887570-7	2018	Collectively, our data demonstrated that curcumin may suppress cAMP-induced steroidogenesis in mouse Leydig cells by down-regulating Nr5a1/Fos-controlled StAR and Cyp11a1 expression independently of the PKA-CREB signaling pathway.	Curcumin	41-49	nuclear receptor subfamily 5, group A, member 1	Mus musculus	133-138
29880071-7	2018	Curcumin significantly attenuated liver injury and fibrosis, including amelioration of liver histological changes, reduction of hepatic enzymes, as well as decreased expression of liver fibrogenesis-associated variables, including Rac1, Rac1-GTP, NOX1, ERK1, HIF-1alpha and Sp1.	Curcumin	0-8	NADPH oxidase 1	Rattus norvegicus	247-251
29880071-7	2018	Curcumin significantly attenuated liver injury and fibrosis, including amelioration of liver histological changes, reduction of hepatic enzymes, as well as decreased expression of liver fibrogenesis-associated variables, including Rac1, Rac1-GTP, NOX1, ERK1, HIF-1alpha and Sp1.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	259-269
29980703-5	2018	We also characterised their effects in ex-vivo psoriasis PBMC and report that curcumin, but not carnosol, strongly reduces T cell proliferation and cytokine poly-functionality, with reduced expression of psoriatic cytokines IFNgamma, IL-17, GM-CSF and IL-22.	Curcumin	78-86	interleukin 17A	Homo sapiens	234-239
29980703-5	2018	We also characterised their effects in ex-vivo psoriasis PBMC and report that curcumin, but not carnosol, strongly reduces T cell proliferation and cytokine poly-functionality, with reduced expression of psoriatic cytokines IFNgamma, IL-17, GM-CSF and IL-22.	Curcumin	78-86	interleukin 22	Homo sapiens	252-257
30057672-5	2018	Curcumin has been reported to have neuroprotective properties in PD models induced by neurotoxins or genetic factors such as alpha-synuclein, PINK1, DJ-1, and LRRK2.	Curcumin	0-8	Leucine-rich repeat kinase	Drosophila melanogaster	159-164
29723613-0	2018	CD44 targeting biocompatible and biodegradable hyaluronic acid cross-linked zein nanogels for curcumin delivery to cancer cells: In vitro and in vivo evaluation.	Curcumin	94-102	CD44 antigen	Mus musculus	0-4
30480167-0	2018	Effects of PCL, PEG and PLGA polymers on curcumin release from calcium phosphate matrix for in vitro and in vivo bone regeneration.	Curcumin	41-49	PHD finger protein 1	Homo sapiens	11-14
30480167-8	2018	Finally, 3D printed interconnected macro porous beta-TCP scaffolds were prepared and curcumin-PCL-PEG was loaded to assess the effects of curcumin on in vivo bone regeneration.	Curcumin	85-93	PHD finger protein 1	Homo sapiens	94-97
29804421-1	2018	Objective: Curcumin was used as photosensitizers in photodynamic therapy on cervical cancer xenografts in nude mice.Analysis the expression changes of Notch and downstream gene as NF-kappaB and VEGF before and after DAPT inhibition of Notch signaling pathway in vivo experiments.Our aim was to investigate the possible mechanism of Notch signaling pathway in the treatment of cervical cancer with PDT.	Curcumin	11-19	vascular endothelial growth factor A	Mus musculus	194-198
29518606-0	2018	Curcumin protects against hepatic stellate cells activation and migration by inhibiting the CXCL12/CXCR4 biological axis in liver fibrosis:A study in vitro and in vivo.	Curcumin	0-8	C-X-C motif chemokine receptor 4	Rattus norvegicus	99-104
29518606-4	2018	Here, we investigated the contribution of curcumin on CXCL12/ CXCR4 biological axis in liver fibrosis.	Curcumin	42-50	C-X-C motif chemokine receptor 4	Rattus norvegicus	62-67
29518606-6	2018	The alleviation of liver fibrosis with curcumin treatment was associated with a reduction of CXCL12, CXCR4, alpha-SMA and RhoA.	Curcumin	39-47	C-X-C motif chemokine receptor 4	Rattus norvegicus	101-106
29518606-6	2018	The alleviation of liver fibrosis with curcumin treatment was associated with a reduction of CXCL12, CXCR4, alpha-SMA and RhoA.	Curcumin	39-47	ras homolog family member A	Rattus norvegicus	122-126
29518606-8	2018	This study indicates that curcumin could protect against hepatic stellate cells activation and migration by inhibiting the CXCL12/CXCR4 biological axis in liver fibrosis.	Curcumin	26-34	C-X-C motif chemokine receptor 4	Rattus norvegicus	130-135
28856444-4	2018	RESULTS: Curcumin, in a dose-dependent manner, reduced ethanol-induced gastric lesions and significantly increased GBF and plasma gastrin levels.	Curcumin	9-17	gastrin	Rattus norvegicus	130-137
28856444-6	2018	Curcumin downregulated Cdx-2 and Hif-1alpha mRNA expression and upregulated HO-1 and SOD 2, and these effects were reversed by L-NNA and further restored by co-treatment of L-NNA with L-arginine.	Curcumin	0-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	33-43
28856444-6	2018	Curcumin downregulated Cdx-2 and Hif-1alpha mRNA expression and upregulated HO-1 and SOD 2, and these effects were reversed by L-NNA and further restored by co-treatment of L-NNA with L-arginine.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	76-80
28856444-6	2018	Curcumin downregulated Cdx-2 and Hif-1alpha mRNA expression and upregulated HO-1 and SOD 2, and these effects were reversed by L-NNA and further restored by co-treatment of L-NNA with L-arginine.	Curcumin	0-8	superoxide dismutase 2	Rattus norvegicus	85-90
28856444-7	2018	CONCLUSIONS: Curcumin-induced protection against ethanol damage involves endogenous PG, NO, gastrin and CGRP released from sensory nerves due to activation of the vanilloid TRPV1 receptor.	Curcumin	13-21	gastrin	Rattus norvegicus	92-99
27819521-0	2018	MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway.	Curcumin	52-60	GLI family zinc finger 1	Homo sapiens	73-77
27819521-4	2018	Moreover, we found that combination treatment of miR-326 and curcumin caused significant inhibition of the SHH/GLI1 pathway in glioma cells compared with either treatment alone, independent of p53 status.	Curcumin	61-69	GLI family zinc finger 1	Homo sapiens	111-115
28417445-7	2018	Curcumin treatment decreased mammary VEGF levels significantly, which likely contributed to slower tumor formation.	Curcumin	0-8	vascular endothelial growth factor A	Mus musculus	37-41
29017189-0	2018	Curcumin Affects Adipose Tissue-Derived Mesenchymal Stem Cell Aging Through TERT Gene Expression.	Curcumin	0-8	telomerase reverse transcriptase	Rattus norvegicus	76-80
29017189-4	2018	The aim of this study is to evaluate the effects of curcumin on proliferation, aging and TERT expression of rat adipose tissue-derived stem cells (rADSC).	Curcumin	52-60	telomerase reverse transcriptase	Rattus norvegicus	89-93
29017189-12	2018	Moreover, expression levels of TERT increased in the presence of 1 and 5 microM curcumin than control group (P&lt;0.001).	Curcumin	80-88	telomerase reverse transcriptase	Rattus norvegicus	31-35
29017189-13	2018	As a conclusion, curcumin may be a good candidate to improve lifespan of rADSCs through promoting TERT gene expression.	Curcumin	17-25	telomerase reverse transcriptase	Rattus norvegicus	98-102
29432842-7	2018	Interestingly, CU or GA co-treatment normalized the levels of circulatory pro- and anti-inflammatory cytokines, chemokines, N-eCML, CRP and HbA1c levels.	Curcumin	15-17	C-reactive protein, pentraxin-related	Mus musculus	132-135
29027056-0	2018	Curcumin affords neuroprotection and inhibits alpha-synuclein aggregation in lipopolysaccharide-induced Parkinson"s disease model.	Curcumin	0-8	synuclein alpha	Rattus norvegicus	46-61
29027056-2	2018	Curcumin, which plays a neuroprotective role in various animal models of PD, was found to directly modulate the aggregation of alpha-synuclein in in vitro as well as in in vivo studies.	Curcumin	0-8	synuclein alpha	Rattus norvegicus	127-142
29027056-3	2018	While curcumin has been shown to exhibit strong anti-oxidant and anti-inflammatory properties, there are a number of other possible mechanisms by which curcumin may alter alpha-synuclein aggregation which still remains obscure.	Curcumin	152-160	synuclein alpha	Rattus norvegicus	171-186
29027056-7	2018	Modulatory functions of curcumin were evident from the inhibition of astrocytic activation (GFAP) by immunofluorescence and NADPH oxidase complex activation by RT-PCR.	Curcumin	24-32	glial fibrillary acidic protein	Rattus norvegicus	92-96
29027056-10	2018	Curcumin also prevented alpha-synuclein aggregates in the dopaminergic neurons as observed from gene as well as protein activity of alpha-synuclein using RT-PCR and IHC.	Curcumin	0-8	synuclein alpha	Rattus norvegicus	24-39
29027056-10	2018	Curcumin also prevented alpha-synuclein aggregates in the dopaminergic neurons as observed from gene as well as protein activity of alpha-synuclein using RT-PCR and IHC.	Curcumin	0-8	synuclein alpha	Rattus norvegicus	132-147
29485312-3	2018	Most of the beneficial effects of Curcumin are possibly due to activation of the nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARgamma).	Curcumin	34-42	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	149-158
29485312-4	2018	The present study investigates molecular interactions of curcumin with PPARgamma protein through molecular docking and molecular dynamics (MD) simulation studies.	Curcumin	57-65	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	71-80
29485312-6	2018	Computational studies presented several significant molecular interactions of curcumin including Ser289, His323, His449 and Tyr473 of PPARgamma.	Curcumin	78-86	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	134-143
29485312-7	2018	The in vivo results further confirmed that curcumin was able to ameliorate the abnormal changes and also, increased PPARgamma expressions.	Curcumin	43-51	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	116-125
29485312-8	2018	The results confirm our hypothesis that activation of PPARgamma by curcumin possesses the therapeutic potential to ameliorate the altered levels of metabolic changes in rats in the treatment of CMetS.	Curcumin	67-75	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	54-63
29393445-3	2018	The effects of JAK2/STAT3 inhibitor and curcumin on the expression of p-JAK2, p-STAT3, HMGB1, and inflammatory factors after cerebral ischemia were observed with ELISA, western blotting and immunohistochemical staining.	Curcumin	40-48	Janus kinase 2	Rattus norvegicus	72-76
29393445-3	2018	The effects of JAK2/STAT3 inhibitor and curcumin on the expression of p-JAK2, p-STAT3, HMGB1, and inflammatory factors after cerebral ischemia were observed with ELISA, western blotting and immunohistochemical staining.	Curcumin	40-48	high mobility group box 1	Rattus norvegicus	87-92
29436680-16	2018	Overall, these data indicated that curcumin activates the Nrf2-ARE signaling pathway and upregulates HO-1 expression, which mediates SR-BI and ABCA1 expression and thereby increases cholesterol efflux.	Curcumin	35-43	ATP binding cassette subfamily A member 1	Homo sapiens	143-148
29747745-10	2018	The transcript quantity of manganese-superoxide dismutase gene (Mn-SOD) was highly accumulated (3.25 and 3.87-fold) in the heart tissue sample of the induced diabetic rats in response to both nano-Curcumin and AGE suspension respectively.	Curcumin	197-205	superoxide dismutase 2	Rattus norvegicus	27-62
29747745-10	2018	The transcript quantity of manganese-superoxide dismutase gene (Mn-SOD) was highly accumulated (3.25 and 3.87-fold) in the heart tissue sample of the induced diabetic rats in response to both nano-Curcumin and AGE suspension respectively.	Curcumin	197-205	superoxide dismutase 2	Rattus norvegicus	64-70
29466778-3	2018	We developed new curcumin analogs (MACs) with removal of the beta-diketone moiety and substituted residues in benzene rings, and identify these as potential MD2 inhibitors with improved inhibition potency and stability over that of curcumin.	Curcumin	232-240	lymphocyte antigen 96	Homo sapiens	157-160
29237386-0	2018	The Combined Effects of omega -3 Fatty Acids and Nano-Curcumin Supplementation on Intercellular Adhesion Molecule-1 (ICAM-1) Gene Expression and Serum Levels in Migraine Patients.	Curcumin	54-62	intercellular adhesion molecule 1	Homo sapiens	82-115
29237386-0	2018	The Combined Effects of omega -3 Fatty Acids and Nano-Curcumin Supplementation on Intercellular Adhesion Molecule-1 (ICAM-1) Gene Expression and Serum Levels in Migraine Patients.	Curcumin	54-62	intercellular adhesion molecule 1	Homo sapiens	117-123
29237386-3	2018	Curcumin and omega-3 fatty acids, by affecting transcription factors, can regulate the gene expression and serum levels of ICAM-1.	Curcumin	0-8	intercellular adhesion molecule 1	Homo sapiens	123-129
29237386-4	2018	Thus, this study aimed to evaluate the synergistic effects of omega-3 fatty acids and nano-curcumin on ICAM-1 gene expression and serum levels in migraine patients.	Curcumin	91-99	intercellular adhesion molecule 1	Homo sapiens	103-109
29237386-10	2018	CONCLUSION: Considering the results of supplementation with omega-3 fatty acids plus curcumin led to reductions of both attack frequency and ICAM-1 serum level in patients, it seems that supplementation with these two nutrients not only can lead to improvements in the function of metabolic pathways, but can also be used effectively as a treatment or prevention of migraine complications.	Curcumin	85-93	intercellular adhesion molecule 1	Homo sapiens	141-147
29356693-7	2018	We further illustrated that curcumin effectively decreased breast CSCs activity by inhibiting tumor sphere formation, decreasing breast CSCs markers (CD44, ALDH1A1, Nanog, and Oct4), as well as inhibiting proliferation and inducing apoptosis.	Curcumin	28-36	CD44 molecule (Indian blood group)	Homo sapiens	150-154
29139094-13	2018	CONCLUSION: Curcumin might have therapeutic potential in breast cancer through regulating breast cancer-related genes, including SERPINE1, PGAP3, MAP3K1, MAPK1, GSTO2, VIM, SPARC, and FGF2.	Curcumin	12-20	glutathione S-transferase omega 2	Homo sapiens	161-166
29480285-0	2018	Curcumin Attenuates Pulmonary Inflammation in Lipopolysaccharide Induced Acute Lung Injury in Neonatal Rat Model by Activating Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) Pathway.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	127-175
29480285-0	2018	Curcumin Attenuates Pulmonary Inflammation in Lipopolysaccharide Induced Acute Lung Injury in Neonatal Rat Model by Activating Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) Pathway.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	177-186
29480285-9	2018	Curcumin treatment upregulated the PPARgamma activity and expression level of HO1 which were suppressed in lung tissue of neonatal ALI rats.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	35-44
29480285-9	2018	Curcumin treatment upregulated the PPARgamma activity and expression level of HO1 which were suppressed in lung tissue of neonatal ALI rats.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	78-81
29480285-10	2018	Elevated levels of HMGB1, RAGE, TNFalpha, IL6, and TGFbeta1 in both lung tissue and BALF from neonatal ALI rats were decreased dramatically by curcumin treatment.	Curcumin	143-151	high mobility group box 1	Rattus norvegicus	19-24
29480285-11	2018	PPARgamma inhibitor BADGE administration impaired curcumin"s alleviation on lung edema, inhibitory effects on inflammatory cytokine expression and recovery of PPARg/HO1 signaling activation.	Curcumin	50-58	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	0-9
29480285-11	2018	PPARgamma inhibitor BADGE administration impaired curcumin"s alleviation on lung edema, inhibitory effects on inflammatory cytokine expression and recovery of PPARg/HO1 signaling activation.	Curcumin	50-58	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	0-5
29480285-12	2018	CONCLUSIONS Curcumin alleviated lung edema in LPS-induced ALI by inhibiting inflammation which was induced by PPARgamma/HO1 regulated-HMGB1/RAGE pro-inflammatory pathway.	Curcumin	12-20	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	110-119
29480285-12	2018	CONCLUSIONS Curcumin alleviated lung edema in LPS-induced ALI by inhibiting inflammation which was induced by PPARgamma/HO1 regulated-HMGB1/RAGE pro-inflammatory pathway.	Curcumin	12-20	heme oxygenase 1	Rattus norvegicus	120-123
29480285-12	2018	CONCLUSIONS Curcumin alleviated lung edema in LPS-induced ALI by inhibiting inflammation which was induced by PPARgamma/HO1 regulated-HMGB1/RAGE pro-inflammatory pathway.	Curcumin	12-20	high mobility group box 1	Rattus norvegicus	134-139
29228771-0	2018	Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells.	Curcumin	0-8	translocating chain-associating membrane protein 1	Mus musculus	108-113
29228308-9	2018	Via inhibition of RXRalpha, curcumin suppressed CSC-like phenotypes induced by CDDP.	Curcumin	28-36	retinoid X receptor alpha	Homo sapiens	18-26
29353037-2	2018	Post oxygen and glucose deprivation/reoxygenation (OGD/R), primary mouse cortical neurons treated with curcumin exhibited a significant decrease in cell death, LDH release and enzyme caspase-3 activity under OGD/R circumstances, which were abolished by flotillin-1 downregulation or extracellular signal-regulated kinase (ERK) inhibitor.	Curcumin	103-111	caspase 3	Mus musculus	183-192
29401702-4	2018	DHA and curcumin induce the expression of LCE3A/LCE3D/LCE3E mRNAs at concentrations corresponding to their affinity for VDR.	Curcumin	8-16	late cornified envelope 3D	Homo sapiens	48-53
29401702-4	2018	DHA and curcumin induce the expression of LCE3A/LCE3D/LCE3E mRNAs at concentrations corresponding to their affinity for VDR.	Curcumin	8-16	vitamin D receptor	Homo sapiens	120-123
29401702-6	2018	Finally, DHA and curcumin modulate two transcription factors relevant to psoriatic inflammation, the activator protein-1 factor Jun B and the nuclear receptor NR4A2/NURR1, that is implicated as a mediator of VDR ligand-triggered gene control.	Curcumin	17-25	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	101-120
29401702-6	2018	Finally, DHA and curcumin modulate two transcription factors relevant to psoriatic inflammation, the activator protein-1 factor Jun B and the nuclear receptor NR4A2/NURR1, that is implicated as a mediator of VDR ligand-triggered gene control.	Curcumin	17-25	nuclear receptor subfamily 4 group A member 2	Homo sapiens	159-164
29401702-6	2018	Finally, DHA and curcumin modulate two transcription factors relevant to psoriatic inflammation, the activator protein-1 factor Jun B and the nuclear receptor NR4A2/NURR1, that is implicated as a mediator of VDR ligand-triggered gene control.	Curcumin	17-25	nuclear receptor subfamily 4 group A member 2	Homo sapiens	165-170
29401702-6	2018	Finally, DHA and curcumin modulate two transcription factors relevant to psoriatic inflammation, the activator protein-1 factor Jun B and the nuclear receptor NR4A2/NURR1, that is implicated as a mediator of VDR ligand-triggered gene control.	Curcumin	17-25	vitamin D receptor	Homo sapiens	208-211
29479379-5	2018	IL-6, tumor necrosis factor (TNF)-alpha, and intercellular adhesion molecule (ICAM)-1 concentrations were lower in curcumin pretreated animals when compared to control animals.	Curcumin	115-123	intercellular adhesion molecule 1	Sus scrofa	45-85
29479379-7	2018	Conclusions: This project may provide information for the development of a translational study in humans as we noted that curcumin pretreatment in a large animal model of cardiopulmonary bypass (CPB) and extracorporeal support resulted in a decrease in TNF-alpha and ICAM-1 expression compared to control animals.	Curcumin	122-130	intercellular adhesion molecule 1	Homo sapiens	267-273
28902433-14	2018	Curcumin also regulated the BLM and IL-17A mediated changes in p53-PAI-1 expression.	Curcumin	0-8	interleukin 17A	Homo sapiens	36-42
29034440-9	2018	Furthermore, curcumin repressed the capacity of risperidone to induce the hepatic over expression of enzymes involved in lipid metabolism (LXRalpha, FAS, ACC1, LPL, PPARgamma, ACO, SREBP2) and decreased risperidone-induced glucose intolerance and hypertriglyceridemia.	Curcumin	13-21	lipoprotein lipase	Mus musculus	160-163
29034440-9	2018	Furthermore, curcumin repressed the capacity of risperidone to induce the hepatic over expression of enzymes involved in lipid metabolism (LXRalpha, FAS, ACC1, LPL, PPARgamma, ACO, SREBP2) and decreased risperidone-induced glucose intolerance and hypertriglyceridemia.	Curcumin	13-21	sterol regulatory element binding factor 2	Mus musculus	181-187
29351226-1	2018	This study aimed to investigate the protective effect of curcumin against carbon tetrachloride (CCl4)-induced acute liver injury in a mouse model, and to explain the underlying mechanism.	Curcumin	57-65	chemokine (C-C motif) ligand 4	Mus musculus	96-100
29351226-2	2018	Curcumin at doses of 50, 100 and 200 mg/kg/day were administered orally once daily for seven days prior to CCl4 exposure.	Curcumin	0-8	chemokine (C-C motif) ligand 4	Mus musculus	107-111
29351226-3	2018	At 24 h, curcumin-attenuated CCl4 induced elevated serum transaminase activities and histopathological damage in the mouse"s liver.	Curcumin	9-17	chemokine (C-C motif) ligand 4	Mus musculus	29-33
29351226-4	2018	Curcumin pre-treatment at 50, 100 and 200 mg/kg significantly ameliorated CCl4-induced oxidative stress, characterized by decreased malondialdehyde (MDA) formations, and increased superoxide dismutase (SOD), catalase (CAT) activities and glutathione (GSH) content, followed by a decrease in caspase-9 and -3 activities.	Curcumin	0-8	chemokine (C-C motif) ligand 4	Mus musculus	74-78
29351226-5	2018	Curcumin pre-treatment significantly decreased CCl4-induced inflammation.	Curcumin	0-8	chemokine (C-C motif) ligand 4	Mus musculus	47-51
29607740-0	2018	Effects of nano-encapsulated curcumin-chrysin on telomerase, MMPs and TIMPs gene expression in mouse B16F10 melanoma tumour model.	Curcumin	29-37	matrix metallopeptidase 2	Mus musculus	61-65
30580635-7	2018	Curcumin-loaded chitosan nanoparticles were also fabricated to augment the apoptotic effect of TRAIL.	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	95-100
29172709-6	2018	The miR-770-5p and miR-1247 expression levels in the DLK1-DIO3 imprinted gene cluster were significantly different between the curcumin-treated and control HuPCaSCs.	Curcumin	127-135	membrane associated ring-CH-type finger 8	Homo sapiens	4-7
29268977-0	2017	Reverse effect of curcumin on CDDP-induced drug-resistance via Keap1/p62-Nrf2 signaling in A549/CDDP cell.	Curcumin	18-26	nucleoporin 62	Homo sapiens	69-72
28980111-6	2017	In addition, Curcumin administration protects rats against acetamiprid-induced cerebellum toxicity such as increase in AChE and BChE activities, decrease on cells viability, oxidative stress, and an increase of intracellular calcium.	Curcumin	13-21	butyrylcholinesterase	Rattus norvegicus	128-132
29238464-6	2017	Results: It was identified that SIRT3, AMPK, CPT-1A, IDH2 and MnSOD expression significantly decreased in BDL rats compared to sham rats; however, in the curcumin treatment of BDL rats, the expression of these factors increased significantly compared to BDL (P&lt;0.05).	Curcumin	154-162	superoxide dismutase 2	Rattus norvegicus	62-67
29238464-8	2017	Conclusion: Curcumin reduced liver damage and oxidative stress in the liver tissue of BDL rats through up-regulation of SIRT3, AMPK, CPT-1A, IDH2 and MnSOD as well as changing the level of serum lipid profile.	Curcumin	12-20	superoxide dismutase 2	Rattus norvegicus	150-155
28901458-7	2017	In conclusion, the present findings indicate that curcumin may exert protective effects on LIDD development, exerting its action through the regulation of iNOS, COX-2, TGF-beta1/2, MMP-9 and BDNF.	Curcumin	50-58	matrix metallopeptidase 9	Rattus norvegicus	168-186
28901458-7	2017	In conclusion, the present findings indicate that curcumin may exert protective effects on LIDD development, exerting its action through the regulation of iNOS, COX-2, TGF-beta1/2, MMP-9 and BDNF.	Curcumin	50-58	brain-derived neurotrophic factor	Rattus norvegicus	191-195
28843521-4	2017	The expression levels of cell cycle proteins (Ccnd1 and Cdk4) and stem cell markers (Oct4, CD44, and CD133) were decreased in curcumin-treated HuPCaSCs.	Curcumin	126-134	CD44 molecule (Indian blood group)	Homo sapiens	91-95
28992163-0	2017	Pak1 mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression.	Curcumin	52-60	p21 (RAC1) activated kinase 1	Mus musculus	0-4
28992163-6	2017	We found that both insulin and curcumin-stimulated ChREBP expression in Akt-independent but MEK/ERK-dependent manner, involving the inactivation of the transcriptional repressor Oct-1.	Curcumin	31-39	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	178-183
28992163-8	2017	Pak1 inhibition or its genetic deletion attenuated the stimulatory effect of insulin or curcumin on ChREBP expression.	Curcumin	88-96	p21 (RAC1) activated kinase 1	Mus musculus	0-4
28992163-9	2017	Our study hence suggests the existence of a novel signaling cascade Pak1/MEK/ERK/Oct-1 for both insulin and curcumin in exerting their glucose-lowering effect via promoting hepatic ChREBP production, supports the recognition of beneficial functions of ChREBP, and brings us a new overview on dietary polyphenols.	Curcumin	108-116	p21 (RAC1) activated kinase 1	Mus musculus	68-72
28992163-9	2017	Our study hence suggests the existence of a novel signaling cascade Pak1/MEK/ERK/Oct-1 for both insulin and curcumin in exerting their glucose-lowering effect via promoting hepatic ChREBP production, supports the recognition of beneficial functions of ChREBP, and brings us a new overview on dietary polyphenols.	Curcumin	108-116	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	81-86
28608236-14	2017	In contrast, various doses of curcumin attenuated nicotine-induced apoptosis, oxidative stress and inflammation; while elevating P-CREB and BDNF levels.	Curcumin	30-38	brain-derived neurotrophic factor	Rattus norvegicus	140-144
28608236-15	2017	Thus, curcumin via activation of P-CREB/BDNF signaling pathway, confers neuroprotection against nicotine-induced inflammation, apoptosis and oxidative stress.	Curcumin	6-14	brain-derived neurotrophic factor	Rattus norvegicus	40-44
28894373-6	2017	The expression of proliferating cell nuclear antigen (PCNA) was restored in the testis tissues of diabetic rats at the end of curcumin treatment.	Curcumin	126-134	proliferating cell nuclear antigen	Rattus norvegicus	18-52
28894373-9	2017	CONCLUSION: Curcumin treatment preserved the morphology of testes; restored the expression of PCNA, MDA, and SOD; and inhibited testicular cell death in diabetic rats.	Curcumin	12-20	proliferating cell nuclear antigen	Rattus norvegicus	94-98
29245915-10	2017	Multiplex analyses of plasma taken after drug exposure at animal nadir indicated that the levels of M-CSF, CXCL-9, PDGF and G-CSF were significantly increased by [curcumin + sildenafil] and that expression of CXCL1 and CCL5 were significantly reduced.	Curcumin	163-171	C-C motif chemokine ligand 5	Homo sapiens	219-223
28781627-9	2017	The present study indicated that curcumin attenuates hypoxic-ischemic brain injury in neonatal rats through the induction of Nrf2 and HO-1.	Curcumin	33-41	heme oxygenase 1	Rattus norvegicus	134-138
28391715-7	2017	In addition, curcumin treatment reduced the expression of DNMT1 and DNMT3B, which contribute to promoter hypermethylation of the miR-143/miR-145 cluster.	Curcumin	13-21	DNA methyltransferase 1	Homo sapiens	58-63
28429187-9	2017	Moreover, curcumin increased the hepatic glycogen content by inhibiting glycogen synthase kinase (GSK)-3beta and prevented gluconeogenesis by inhibiting phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase).	Curcumin	10-18	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	153-186
28429187-9	2017	Moreover, curcumin increased the hepatic glycogen content by inhibiting glycogen synthase kinase (GSK)-3beta and prevented gluconeogenesis by inhibiting phosphoenolpyruvate carboxykinase (PEPCK) and glucose 6-phosphatase (G6Pase).	Curcumin	10-18	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	188-193
28728293-11	2017	In addition, the formation of acidic vesicular organelles in cytoplasm, conversion of LC3-I to LC3-II and increased levels of autophagy-related proteins Beclin1, Atg7 and Atg5-Atg12 were observed in curcumin-treated cells.	Curcumin	199-207	beclin 1	Homo sapiens	153-160
28611265-11	2017	In vitro, curcumin (50 microM) decreased HepG2 cells viabilityand the concentration of SQSTM1.	Curcumin	10-18	sequestosome 1	Homo sapiens	87-93
28539160-3	2017	Jab1 stimulated phosphorylation of p53 at T155 was inhibited by curcumin, an inhibitor of COP9 signalosome (CSN)-associated kinases.	Curcumin	64-72	COP9 signalosome subunit 5	Homo sapiens	0-4
26651837-8	2017	Immunoblot and immunohistochemical analyses were performed to analyze c-Jun levels in hippocampal neurons treated with either ET-1 or a combination of ET-1 and curcumin.	Curcumin	160-168	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	70-75
26651837-11	2017	Co-treatment with curcumin significantly attenuated the ET-1 mediated increase in c-Jun levels.	Curcumin	18-26	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	82-87
26651837-14	2017	DISCUSSION: Our data suggests that one mechanism by which curcumin protects against ET-1-mediated cell death is through blocking an increase in c-Jun levels.	Curcumin	58-66	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	144-149
28618934-7	2017	Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 and ITGA2B), collagen ( COL5A1), and laminin ( LAMA5) were significantly inhibited by curcumin at messenger RNA and protein levels.	Curcumin	191-199	integrin alpha 3	Mus musculus	99-104
28618934-7	2017	Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 and ITGA2B), collagen ( COL5A1), and laminin ( LAMA5) were significantly inhibited by curcumin at messenger RNA and protein levels.	Curcumin	191-199	collagen, type V, alpha 1	Mus musculus	129-135
28273557-8	2017	Furthermore, expression of the Th17 cells related cytokine profiles (IL-17A and RORgammat) was dramatically decreased in curcumin-treated groups.	Curcumin	121-129	interleukin 17A	Mus musculus	69-75
27003823-9	2017	Curcumin pre-treatment followed by paraquat exposure rescued cell viability and increased MMP and mitochondrial respiration in control cells, and significantly decreased apoptosis and increased MMP and maximal respiration in PINK1 siRNA cells.	Curcumin	0-8	PTEN induced kinase 1	Homo sapiens	225-230
27003823-10	2017	These results highlight a protective effect of curcumin against mitochondrial dysfunction and apoptosis in PINK1-deficient and paraquat-exposed cells.	Curcumin	47-55	PTEN induced kinase 1	Homo sapiens	107-112
28302511-0	2017	Design, synthesis and biological evaluation of multifunctional tacrine-curcumin hybrids as new cholinesterase inhibitors with metal ions-chelating and neuroprotective property.	Curcumin	71-79	butyrylcholinesterase	Rattus norvegicus	95-109
28359291-9	2017	Furthermore, curcumin dramatically decreased mtDNA content and DNA polymerase gamma (POLG) which contributed to reduced mitochondrial oxygen consumption and aerobic glycolysis.	Curcumin	13-21	polymerase (DNA directed), gamma	Mus musculus	85-89
28359291-10	2017	We found that curcumin induced POLG depletion via ROS generation, and POLG knockdown also reduced oxidative phosphorylation (OXPHOS) activity and cellular glycolytic rate which was partially rescued by ROS scavenger NAC, indiating POLG plays an important role in the treatment of gastric cancer.	Curcumin	14-22	polymerase (DNA directed), gamma	Mus musculus	31-35
28359291-10	2017	We found that curcumin induced POLG depletion via ROS generation, and POLG knockdown also reduced oxidative phosphorylation (OXPHOS) activity and cellular glycolytic rate which was partially rescued by ROS scavenger NAC, indiating POLG plays an important role in the treatment of gastric cancer.	Curcumin	14-22	NLR family, pyrin domain containing 1A	Mus musculus	216-219
28359291-13	2017	CONCLUSIONS: Together, our data suggest a novel mechanism by which curcumin inhibited gastric tumor growth through excessive ROS generation, resulting in depletion of POLG and mtDNA, and the subsequent disruption of cellular bioenergetics.	Curcumin	67-75	polymerase (DNA directed), gamma	Mus musculus	167-171
28348486-0	2017	Therapeutic effect of curcumin on experimental colitis mediated by inhibiting CD8+CD11c+ cells.	Curcumin	22-30	CD8a molecule	Homo sapiens	78-81
28348486-1	2017	AIM: To verify whether curcumin (Cur) can treat inflammatory bowel disease by regulating CD8+CD11c+ cells.	Curcumin	23-31	CD8a molecule	Homo sapiens	89-92
27990751-5	2017	METHODS AND RESULTS: Glucose tolerance was significantly improved in rats after pre-administered curcumin (1.5 mg/kg) followed by intraperitoneal glucose injections via the stimulation of GLP-1 secretion and the induction of insulin secretion.	Curcumin	97-105	glucagon	Rattus norvegicus	188-193
27990751-7	2017	Furthermore, the glucose-lowering effect induced by curcumin was significantly reduced after the administration of a GPR40/120 antagonist in rats.	Curcumin	52-60	free fatty acid receptor 1	Rattus norvegicus	117-122
27996348-5	2017	Compared with FZD alone group, curcumin pretreatment significantly reduced the expression of phospho (p)-p38, cyclin D1, p-checkpoint kinase 1 (ChK1) and breast cancer associated gene 1 (BRCA1) protein, followed to attenuate S phase arrest.	Curcumin	31-39	BRCA1 DNA repair associated	Homo sapiens	154-185
27996348-5	2017	Compared with FZD alone group, curcumin pretreatment significantly reduced the expression of phospho (p)-p38, cyclin D1, p-checkpoint kinase 1 (ChK1) and breast cancer associated gene 1 (BRCA1) protein, followed to attenuate S phase arrest.	Curcumin	31-39	BRCA1 DNA repair associated	Homo sapiens	187-192
28261097-0	2017	Curcumin Alleviates oxLDL Induced MMP-9 and EMMPRIN Expression through the Inhibition of NF-kappaB and MAPK Pathways in Macrophages.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	34-39
28261097-4	2017	Here we evaluated the impact of curcumin on the expression of MMP-9 and EMMPRIN in macrophages.	Curcumin	32-40	matrix metallopeptidase 9	Homo sapiens	62-67
28261097-8	2017	Here we showed that curcumin attenuated the MMP-9 and EMMPRIN expression in oxLDL stimulated macrophages.	Curcumin	20-28	matrix metallopeptidase 9	Homo sapiens	44-49
28261097-10	2017	These findings illustrated that curcumin can inhibit the expression of EMMPRIN and MMP-9 in oxLDL stimulated macrophages through down regulation of NF-kappaB and p38 MAPK signaling pathways, which might be the molecular mechanism for the anti-atherosclerotic effect of curcumin.	Curcumin	32-40	matrix metallopeptidase 9	Homo sapiens	83-88
27491636-0	2017	Curcumin improves episodic memory in cadmium induced memory impairment through inhibition of acetylcholinesterase and adenosine deaminase activities in a rat model.	Curcumin	0-8	adenosine deaminase	Rattus norvegicus	118-137
27721157-5	2017	Studies indicate that IP-13 and IP-15 showed better AChE inhibitory activity than the standard drug donepezil and IP-9, IP-13 as well as IP-15 exhibited better Abeta aggregation inhibitory activity than curcumin.	Curcumin	203-211	C-X-C motif chemokine ligand 11	Homo sapiens	114-118
27355903-2	2017	In Ldlr-/- mice fed a high-fat diet (HFD), curcumin reduces plasma lipid levels, therefore contributing to a lower accumulation of lipids and to reduced expression of fatty acid transport proteins (CD36/FAT, FABP4/aP2) in peritoneal macrophages.	Curcumin	43-51	low density lipoprotein receptor	Mus musculus	3-7
27355903-3	2017	In this study, we analyzed the molecular mechanisms by which curcumin (500, 1000, 1500 mg/kg diet, for 4 months) may influence plasma and tissue lipid levels in Ldlr-/- mice fed an HFD.	Curcumin	61-69	low density lipoprotein receptor	Mus musculus	161-165
27355903-6	2017	Treatment with curcumin increased phosphorylation of CREB in liver, what may play a role in regulatory effects of curcumin in lipid homeostasis.	Curcumin	15-23	cAMP responsive element binding protein 1	Homo sapiens	53-57
27355903-6	2017	Treatment with curcumin increased phosphorylation of CREB in liver, what may play a role in regulatory effects of curcumin in lipid homeostasis.	Curcumin	114-122	cAMP responsive element binding protein 1	Homo sapiens	53-57
27355903-7	2017	In cell lines, curcumin increased the level of cAMP, activated the transcription factor CREB and the human CD36 promoter via a sequence containing a consensus CREB response element.	Curcumin	15-23	cAMP responsive element binding protein 1	Homo sapiens	88-92
27355903-7	2017	In cell lines, curcumin increased the level of cAMP, activated the transcription factor CREB and the human CD36 promoter via a sequence containing a consensus CREB response element.	Curcumin	15-23	cAMP responsive element binding protein 1	Homo sapiens	159-163
27355903-9	2017	Since the cAMP/protein kinase A (PKA)/CREB pathway plays an important role in lipid homeostasis, energy expenditure, and thermogenesis by increasing lipolysis and fatty acid beta-oxidation, an increase in cAMP levels induced by curcumin may contribute to its hypolipidemic and anti-atherosclerotic effects.	Curcumin	228-236	cAMP responsive element binding protein 1	Homo sapiens	38-42
27829579-7	2017	When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin.	Curcumin	47-55	S100 calcium binding protein A4	Homo sapiens	188-192
27829579-7	2017	When HKCs were co-incubated with TGF-beta1 and curcumin for 72 h, curcumin maintained the epithelial morphology in a dose-dependent manner, decreased expression of vimentin, alpha-SMA and FSP1 normally induced by TGF-beta1, and increased expression of E-cadherin, cytokeratin.	Curcumin	66-74	S100 calcium binding protein A4	Homo sapiens	188-192
29292884-0	2016	[JAK2/STAT3 signal pathway mediating curcumin in cartilage cell metabolism of osteoarthritis].	Curcumin	37-45	Janus kinase 2	Rattus norvegicus	1-5
29292884-1	2016	OBJECTIVE: To observe influence of JAK2/STAT3 signal pathway mediating curcumin in cartilage cell metabolism of osteoarthritis and mitochondria oxidative stress resistance;also explore the role of JAK2/STAT3 signal pathway and effect of curcumin in this process.	Curcumin	71-79	Janus kinase 2	Rattus norvegicus	35-39
29292884-1	2016	OBJECTIVE: To observe influence of JAK2/STAT3 signal pathway mediating curcumin in cartilage cell metabolism of osteoarthritis and mitochondria oxidative stress resistance;also explore the role of JAK2/STAT3 signal pathway and effect of curcumin in this process.	Curcumin	237-245	Janus kinase 2	Rattus norvegicus	35-39
29292884-5	2016	Compared with control group, p-JAK2, p-STAT3 protein expression was decreased in OA and curcumin with OA group(P&lt;0.05), Bax protein expression was increased (P&lt;0.05), SDA and COX protein expression were reduced (P&lt;0.05).	Curcumin	88-96	Janus kinase 2	Rattus norvegicus	31-35
29292884-6	2016	Compared with OA group, p-JAK2, p-STAT3 protein expression was increased in curcumin with OA, Bax protein expression was decreased (P&lt;0.05), SDA and COX protein expression were increased (P&lt;0.05), and had statistical differences among three groups.	Curcumin	76-84	Janus kinase 2	Rattus norvegicus	26-30
27789120-8	2016	Curcumin was found to exert diverse immunomodulatory effects, including suppression of IL-4, IL-8, and tumor necrosis factor alpha and increased production of IL-10 and soluble intercellular adhesion molecule.	Curcumin	0-8	interleukin 10	Homo sapiens	159-164
27916071-6	2016	Results: (1) The intracellular expression of miR-155 in the LPS group was (2.13+-0.22) times of the control group (P&lt;0.01); and the expressions of miR-155 in 12.5, 25, 50 mumol/L curcumin+LPS groups were (0.37+-0.08) , (0.68+-0.14) , (0.49+-0.09) times as the LPS group, with statistically significant difference (P&lt;0.05).	Curcumin	182-190	microRNA 155	Homo sapiens	45-52
27916071-6	2016	Results: (1) The intracellular expression of miR-155 in the LPS group was (2.13+-0.22) times of the control group (P&lt;0.01); and the expressions of miR-155 in 12.5, 25, 50 mumol/L curcumin+LPS groups were (0.37+-0.08) , (0.68+-0.14) , (0.49+-0.09) times as the LPS group, with statistically significant difference (P&lt;0.05).	Curcumin	182-190	microRNA 155	Homo sapiens	150-157
27916071-19	2016	Conclusion: The treatment of curcumin could downregulate the expression of NF-kappaB/miR-155, thus inhibit NF-kappaB signal pathway and the apoptosis of extravillus trophoblast cells, and protect their invasive ability.	Curcumin	29-37	microRNA 155	Homo sapiens	85-92
27832139-8	2016	In summary, curcumin treatment might produce a P73-dependent apoptotic cell death in chronic myelogenous leukemia cells (K562), which was triggered by mitotic catastrophe, due to sustained BAX and survivin expression and impairment of the anti-apoptotic proteins BCL-2 and XIAP.	Curcumin	12-20	X-linked inhibitor of apoptosis	Homo sapiens	273-277
27895783-0	2016	Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF-kappaB, uPA activator and MMP9.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	107-111
27895783-3	2016	The present study investigated the hypothesis that curcumin inhibits colon cancer cell invasion by modulating NF-kappaB-mediated expression and activation of uPA and MMP9.	Curcumin	51-59	matrix metallopeptidase 9	Homo sapiens	166-170
27895783-7	2016	Compound C, a potent AMPK inhibitor, abolished curcumin-induced inhibition of NF-kappaB, uPA and MMP9, suggesting that AMPK activation is responsible for curcumin-mediated NF-kappaB, uPA and MMP9 inhibition.	Curcumin	47-55	matrix metallopeptidase 9	Homo sapiens	97-101
27895783-7	2016	Compound C, a potent AMPK inhibitor, abolished curcumin-induced inhibition of NF-kappaB, uPA and MMP9, suggesting that AMPK activation is responsible for curcumin-mediated NF-kappaB, uPA and MMP9 inhibition.	Curcumin	47-55	matrix metallopeptidase 9	Homo sapiens	191-195
27895783-7	2016	Compound C, a potent AMPK inhibitor, abolished curcumin-induced inhibition of NF-kappaB, uPA and MMP9, suggesting that AMPK activation is responsible for curcumin-mediated NF-kappaB, uPA and MMP9 inhibition.	Curcumin	154-162	matrix metallopeptidase 9	Homo sapiens	191-195
27895783-8	2016	The binding activity of NF-kappaB to DNA was examined and western blotting and quantitative polymerase reaction was performed to detect the effect of curcumin on the expression of uPA and MMP9.	Curcumin	150-158	matrix metallopeptidase 9	Homo sapiens	188-192
27895783-9	2016	The present results revealed that curcumin significantly decreased the expression of uPA and MMP9 and NF-kappaB DNA binding activity.	Curcumin	34-42	matrix metallopeptidase 9	Homo sapiens	93-97
27895783-10	2016	Furthermore, curcumin decreased the level of the p65 subunit of NF-kappaB binding to the promoter of the gene encoding uPA and MMP9, which suppressed transcriptional activation of uPA and MMP9.	Curcumin	13-21	matrix metallopeptidase 9	Homo sapiens	127-131
27895783-10	2016	Furthermore, curcumin decreased the level of the p65 subunit of NF-kappaB binding to the promoter of the gene encoding uPA and MMP9, which suppressed transcriptional activation of uPA and MMP9.	Curcumin	13-21	matrix metallopeptidase 9	Homo sapiens	188-192
27895783-11	2016	Overall, the present data suggest that curcumin inhibits colon cancer cell invasion via AMPK activation and subsequent inhibition of p65 NF-kappaB, uPA and MMP9.	Curcumin	39-47	matrix metallopeptidase 9	Homo sapiens	156-160
27242185-3	2016	We have previously synthesized several curcumin analogues, of which four compounds were selective inhibitors of 11beta-HSD1.	Curcumin	39-47	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	112-123
27580989-9	2016	The ERK1/2 and SAPK/JNK and their downstream molecules including P90RSK and c-Jun, respectively, were activated by curcumin.	Curcumin	115-123	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-81
27572279-0	2016	Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathways.	Curcumin	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	122-127
27572279-0	2016	Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathways.	Curcumin	0-8	nuclear factor of activated T cells 1	Homo sapiens	128-134
27572279-7	2016	Curcumin inhibited the osteoclastogenic potential of PBMCs, potentially by suppressing activation of extracellular signal-regulated kinases 1 and 2, p38 and c-Jun N-terminal kinase, and inhibiting receptor activator of nuclear factor kappaB (RANK), c-Fos and nuclear factor of activated T cells (NFATc1) expression.	Curcumin	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	249-254
27572279-7	2016	Curcumin inhibited the osteoclastogenic potential of PBMCs, potentially by suppressing activation of extracellular signal-regulated kinases 1 and 2, p38 and c-Jun N-terminal kinase, and inhibiting receptor activator of nuclear factor kappaB (RANK), c-Fos and nuclear factor of activated T cells (NFATc1) expression.	Curcumin	0-8	nuclear factor of activated T cells 1	Homo sapiens	296-302
27572279-8	2016	The results of the present study demonstrated that curcumin may inhibit the osteoclastogenic potential of PBMCs from patients with RA through the suppression of the mitogen-activated protein kinase/RANK/c-Fos/NFATc1 signaling pathways, and that curcumin may be a potential novel therapeutic agent for the treatment of bone deterioration in inflammatory diseases such as RA.	Curcumin	51-59	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	203-208
27572279-8	2016	The results of the present study demonstrated that curcumin may inhibit the osteoclastogenic potential of PBMCs from patients with RA through the suppression of the mitogen-activated protein kinase/RANK/c-Fos/NFATc1 signaling pathways, and that curcumin may be a potential novel therapeutic agent for the treatment of bone deterioration in inflammatory diseases such as RA.	Curcumin	51-59	nuclear factor of activated T cells 1	Homo sapiens	209-215
27423629-6	2016	Our data also showed that curcumin inhibits oxidative stress-induced cytoskeleton disarrangement, and impedes the activation of astrocytes by inhibiting upregulation of GFAP, vimentin and Prdx6.	Curcumin	26-34	glial fibrillary acidic protein	Homo sapiens	169-173
27499229-6	2016	We found that curcumin at 13 microM increased the protein levels associated with DNA damage and repair, such as O6-methylguanine-DNA methyltransferase, early-onset breast cancer 1 (BRCA1), mediator of DNA damage checkpoint 1, p-p53 and p-H2A.XSer140 in HeLa cells.	Curcumin	14-22	O-6-methylguanine-DNA methyltransferase	Homo sapiens	112-150
27499229-6	2016	We found that curcumin at 13 microM increased the protein levels associated with DNA damage and repair, such as O6-methylguanine-DNA methyltransferase, early-onset breast cancer 1 (BRCA1), mediator of DNA damage checkpoint 1, p-p53 and p-H2A.XSer140 in HeLa cells.	Curcumin	14-22	BRCA1 DNA repair associated	Homo sapiens	164-179
27499229-6	2016	We found that curcumin at 13 microM increased the protein levels associated with DNA damage and repair, such as O6-methylguanine-DNA methyltransferase, early-onset breast cancer 1 (BRCA1), mediator of DNA damage checkpoint 1, p-p53 and p-H2A.XSer140 in HeLa cells.	Curcumin	14-22	BRCA1 DNA repair associated	Homo sapiens	181-186
27572503-12	2016	Curcumin and NAC were able to inhibit H2O2-induced ROS production, reduce the migration and invasion, and decrease the expression of MMP-2 and MMP-9 in pancreatic cancer cells.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	143-148
27568287-0	2016	SIRT1-mediated deacetylation of PGC1alpha attributes to the protection of curcumin against glutamate excitotoxicity in cortical neurons.	Curcumin	74-82	sirtuin 1	Homo sapiens	0-5
27568287-4	2016	In this study, we explored whether the silent information regulator 1 (SIRT1)-peroxisome proliferator-activated receptor-coactivator 1alpha (PGC1alpha) pathway participated in the protection of curcumin against glutamate excitotoxicity.	Curcumin	194-202	sirtuin 1	Homo sapiens	39-69
27568287-4	2016	In this study, we explored whether the silent information regulator 1 (SIRT1)-peroxisome proliferator-activated receptor-coactivator 1alpha (PGC1alpha) pathway participated in the protection of curcumin against glutamate excitotoxicity.	Curcumin	194-202	sirtuin 1	Homo sapiens	71-76
27568287-9	2016	Meanwhile, curcumin preserved mitochondrial function, increased the expression level of SIRT1 and reduced the level of ac-PGC1alpha in the presence of glutamate.	Curcumin	11-19	sirtuin 1	Homo sapiens	88-93
27568287-10	2016	These results suggest that SIRT1-mediated deacetylation of PGC1alpha attributes to the neuroprotection of curcumin against glutamate excitotoxicity.	Curcumin	106-114	sirtuin 1	Homo sapiens	27-32
27194344-10	2016	Both TNF-alpha and PIF significantly reduced myotube diameter from 17 to 13 mum for TNF-alpha (23.5%) and 15 mum (11.8%) for PIF However the triple combination of EPA, curcumin and GTE returned diameters to values not significantly different from the control.	Curcumin	168-176	dermcidin	Homo sapiens	19-22
27573203-7	2016	Results showed that curcumin decreased E-cadherin, N-cadherin, beta-catenin, Slug, AXL, Twist1, Vimentin and Fibronectin protein expression, independently of the positivity of the markers in the cell lines.	Curcumin	20-28	cadherin 2	Mus musculus	51-61
27573203-7	2016	Results showed that curcumin decreased E-cadherin, N-cadherin, beta-catenin, Slug, AXL, Twist1, Vimentin and Fibronectin protein expression, independently of the positivity of the markers in the cell lines.	Curcumin	20-28	catenin (cadherin associated protein), beta 1	Mus musculus	63-75
27573203-7	2016	Results showed that curcumin decreased E-cadherin, N-cadherin, beta-catenin, Slug, AXL, Twist1, Vimentin and Fibronectin protein expression, independently of the positivity of the markers in the cell lines.	Curcumin	20-28	twist basic helix-loop-helix transcription factor 1	Mus musculus	88-94
27573203-7	2016	Results showed that curcumin decreased E-cadherin, N-cadherin, beta-catenin, Slug, AXL, Twist1, Vimentin and Fibronectin protein expression, independently of the positivity of the markers in the cell lines.	Curcumin	20-28	vimentin	Mus musculus	96-104
27350366-0	2016	Silencing of ZRF1 impedes survival of estrogen receptor positive MCF-7 cells and potentiates the effect of curcumin.	Curcumin	107-115	DnaJ heat shock protein family (Hsp40) member C2	Homo sapiens	13-17
27350366-8	2016	Furthermore, we also explored that knockdown of ZRF1 sensitises the effect of curcumin, observed with decrease in cell viability and dropping of IC50 value from 25 to 15 muM.	Curcumin	78-86	DnaJ heat shock protein family (Hsp40) member C2	Homo sapiens	48-52
27594837-3	2016	However, whether PPARgamma activated by curcumin is responsible for the anti-neuroinflammation and neuroprotection on AD remains unclear, and needs to be further investigated.	Curcumin	40-48	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	17-26
27594837-7	2016	Circular dichroism and co-immunoprecipitation analysis showed that curcumin directly bound to PPARgamma and increased the transcriptional activity and protein levels of PPARgamma.	Curcumin	67-75	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	94-103
27594837-7	2016	Circular dichroism and co-immunoprecipitation analysis showed that curcumin directly bound to PPARgamma and increased the transcriptional activity and protein levels of PPARgamma.	Curcumin	67-75	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	169-178
27594837-8	2016	Taking together, these data suggested that PPARgamma might be a potential target of curcumin, acting to alleviate neuroinflammation and improve neuronal function in AD.	Curcumin	84-92	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	43-52
27540290-2	2016	In this study, dual brain-targeting polymersomes (POs) functionalized by transferrin and Tet-1 peptide (Tf/Tet-1-POs) promoted the transportation of curcumin into the brain and provided neuroprotection.	Curcumin	149-157	transferrin	Mus musculus	73-84
27540290-2	2016	In this study, dual brain-targeting polymersomes (POs) functionalized by transferrin and Tet-1 peptide (Tf/Tet-1-POs) promoted the transportation of curcumin into the brain and provided neuroprotection.	Curcumin	149-157	tet methylcytosine dioxygenase 1	Mus musculus	89-94
27540290-2	2016	In this study, dual brain-targeting polymersomes (POs) functionalized by transferrin and Tet-1 peptide (Tf/Tet-1-POs) promoted the transportation of curcumin into the brain and provided neuroprotection.	Curcumin	149-157	tet methylcytosine dioxygenase 1	Mus musculus	107-112
27540290-6	2016	The curcumin-encapsulated Tf/Tet-1-POs provided neuroprotection and ameliorated cognitive dysfunction in intrahippocampal amyloid-beta1-42-injected mice.	Curcumin	4-12	tet methylcytosine dioxygenase 1	Mus musculus	29-34
26081871-0	2016	Promoter methylation-independent reactivation of PAX1 by curcumin and resveratrol is mediated by UHRF1.	Curcumin	57-65	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	97-102
26081871-5	2016	However, a striking correlation between PAX1 reactivation and Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) downregulation after treatment with curcumin and resveratrol in HeLa, SiHa and Caski cell lines was observed which was further confirmed after transient silencing of UHRF1 expression.	Curcumin	156-164	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	62-111
26081871-5	2016	However, a striking correlation between PAX1 reactivation and Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) downregulation after treatment with curcumin and resveratrol in HeLa, SiHa and Caski cell lines was observed which was further confirmed after transient silencing of UHRF1 expression.	Curcumin	156-164	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	113-118
26081871-5	2016	However, a striking correlation between PAX1 reactivation and Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) downregulation after treatment with curcumin and resveratrol in HeLa, SiHa and Caski cell lines was observed which was further confirmed after transient silencing of UHRF1 expression.	Curcumin	156-164	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	286-291
26081871-6	2016	PAX1 reexpression was also obtained in Caski and SiHa cell lines after treatment with sodium butyrate, a histone deacetylase inhibitor, suggesting that PAX1 reactivation by curcumin and resveratrol may be due to their effect on histone deacetylase mediated through downregulation of UHRF1 which can regulate both DNA methylation and histone acetylation.	Curcumin	173-181	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	283-288
27446282-9	2016	In the present study, curcumin demonstrated marked suppression of the LPS-induced expression of MyD88, NF-kappaB, caspase-3, inducible nitric oxide synthase, tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 in the microglia.	Curcumin	22-30	myeloid differentiation primary response gene 88	Mus musculus	96-101
27446282-9	2016	In the present study, curcumin demonstrated marked suppression of the LPS-induced expression of MyD88, NF-kappaB, caspase-3, inducible nitric oxide synthase, tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 in the microglia.	Curcumin	22-30	caspase 3	Mus musculus	114-185
27446282-10	2016	These results indicate that curcumin may exert its neuroprotective and anti-inflammatory effects by inhibiting microglial activation through the HSP60/TLR-4/MyD88/NF-kappaB signaling wpathway.	Curcumin	28-36	myeloid differentiation primary response gene 88	Mus musculus	157-162
26134921-8	2016	Additionally, curcumin partially suppressed SHI-1 cell invasion and attenuated the mRNA transcription and secretion of MMP-2 and MMP-9.	Curcumin	14-22	matrix metallopeptidase 9	Homo sapiens	129-134
26134921-9	2016	DISCUSSION AND CONCLUSION: This study demonstrates that curcumin not only induces SHI-1 cell apoptosis, possibly via both intrinsic and extrinsic pathways triggered by JNK, P38 MAPK and ERK signaling, but also partially suppresses SHI-1 cell invasion, likely by reducing the levels of transcription and secretion of MMP-2 and MMP-9.	Curcumin	56-64	matrix metallopeptidase 9	Homo sapiens	326-331
27306423-0	2016	Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in breast cancer prevention.	Curcumin	28-36	stearoyl-CoA desaturase	Homo sapiens	91-114
27306423-5	2016	We show that curcumin targets both stem cell populations by down-regulating expression of breast stem cell genes including ALDH1A3, CD49f, PROM1, and TP63.	Curcumin	13-21	integrin subunit alpha 6	Homo sapiens	132-137
27278959-10	2016	In addition, curcumin inhibition of alpha-SMA and alpha1(I)procollagen was rescued by BML-275, and curcumin upregulation of C/EBPalpha and PPAR-gamma was abrogated by BML-275.	Curcumin	99-107	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	139-149
27283735-10	2016	Curcumin also decreased Tat mediated LTR promoter transactivation and inhibited virus production from HIV-1 infected cells.	Curcumin	0-8	Tat	Human immunodeficiency virus 1	24-27
27320251-7	2016	Tissue sections from curcumin-treated animals contained significantly greater numbers of BrdU-positive cells (p &lt; 0.05) and BrdU/DCX-positive cells (p &lt; 0.01), as well as significantly higher NICD levels (p &lt; 0.01).	Curcumin	21-29	doublecortin	Rattus norvegicus	132-135
28087906-12	2016	Conclusion: Curcumin could promote the apoptosis of smooth muscle cells in rats with COPD, and improve the mean pulmonary artery pressure and RVMI through stimulating SOCS-3/JAK2/STAT signaling pathway.	Curcumin	12-20	Janus kinase 2	Rattus norvegicus	174-178
26985864-0	2016	Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells.	Curcumin	0-8	fatty acid synthase	Homo sapiens	32-51
26985864-3	2016	In the present study, we investigated the potential activity of curcumin as a FAS inhibitor for chemoprevention of breast cancer.	Curcumin	64-72	fatty acid synthase	Homo sapiens	78-81
26985864-4	2016	As a result, curcumin induced human breast cancer MDA-MB-231 cell apoptosis with the half-inhibitory concentration value of 3.63 +- 0.26 microg/ml, and blocked FAS activity, expression and mRNA level in a dose-dependent manner.	Curcumin	13-21	fatty acid synthase	Homo sapiens	160-163
26985864-6	2016	Moreover, FAS knockdown showed similar effect as curcumin.	Curcumin	49-57	fatty acid synthase	Homo sapiens	10-13
26985864-7	2016	All these results suggested that curcumin may induce cell apoptosis via inhibiting FAS.	Curcumin	33-41	fatty acid synthase	Homo sapiens	83-86
27279695-7	2016	RESULTS: MAO activity was inhibited by curcumin and ellagic acid; however, higher half maximal inhibitory concentrations of curcumin (500.46 nM) and ellagic acid (412.24 nM) were required compared to the known MAO-B inhibitor selegiline.	Curcumin	124-132	monoamine oxidase B	Rattus norvegicus	210-215
27077805-0	2016	Activation of PPARgamma/P53 signaling is required for curcumin to induce hepatic stellate cell senescence.	Curcumin	54-62	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	14-23
27077805-7	2016	At the same time, curcumin induced HSC senescence by elevating the expression of senescence markers P16, P21 and Hmga1, concomitant with reduced abundance of HSC activation markers alpha-smooth muscle actin and alpha1(I)-procollagen in cultured HSCs.	Curcumin	18-26	KRAS proto-oncogene, GTPase	Rattus norvegicus	105-108
27077805-11	2016	Further studies indicated that curcumin promoted the expression of P53 through a PPARgamma activation-dependent mechanism.	Curcumin	31-39	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	81-90
26983836-0	2016	Selective Modulation of Protein Kinase C alpha over Protein Kinase C epsilon by Curcumin and Its Derivatives in CHO-K1 Cells.	Curcumin	80-88	protein kinase C alpha type	Cricetulus griseus	24-46
26915100-8	2016	Our results suggest that curcumin increased HSL levels and other browning-specific markers, suggesting its possible role in augmentation of lipolysis and suppression of lipogenesis by trans-differentiation from white adipocytes into brown adipocytes (beige).	Curcumin	25-33	lipase E, hormone sensitive type	Homo sapiens	44-47
26906122-3	2016	Our cell culture model study found that curcumin treatment (50 muM for 48 h) did indeed increase apoptosis of CRC cells as well as of CCSCs, but at a significant level only in CD44(+) cells.	Curcumin	40-48	CD44 molecule (Indian blood group)	Homo sapiens	176-180
26906122-4	2016	Further metabolic profile studies of the CRC, CD44(+), and CD44(-) cells indicated that curcumin treatment increased glyceraldehyde and hydroxypropionic acid in CD44(-) cells but decreased glutamine content in both curcumin-treated CRC and CD44(+) cells.	Curcumin	88-96	CD44 molecule (Indian blood group)	Homo sapiens	46-50
26906122-4	2016	Further metabolic profile studies of the CRC, CD44(+), and CD44(-) cells indicated that curcumin treatment increased glyceraldehyde and hydroxypropionic acid in CD44(-) cells but decreased glutamine content in both curcumin-treated CRC and CD44(+) cells.	Curcumin	88-96	CD44 molecule (Indian blood group)	Homo sapiens	59-63
26906122-4	2016	Further metabolic profile studies of the CRC, CD44(+), and CD44(-) cells indicated that curcumin treatment increased glyceraldehyde and hydroxypropionic acid in CD44(-) cells but decreased glutamine content in both curcumin-treated CRC and CD44(+) cells.	Curcumin	88-96	CD44 molecule (Indian blood group)	Homo sapiens	59-63
26906122-4	2016	Further metabolic profile studies of the CRC, CD44(+), and CD44(-) cells indicated that curcumin treatment increased glyceraldehyde and hydroxypropionic acid in CD44(-) cells but decreased glutamine content in both curcumin-treated CRC and CD44(+) cells.	Curcumin	88-96	CD44 molecule (Indian blood group)	Homo sapiens	59-63
26906122-5	2016	Based on our comparison of the metabolic profiles of human tissues and cancer cells, we suggest that curcumin might couple with CD44 and that curcumin-CD44(+) coupling at the cell membrane might have some blocking effect on the transport of glutamine into the cells, thus decreasing the glutamine content in the CD44(+) cells and inducing apoptosis.	Curcumin	101-109	CD44 molecule (Indian blood group)	Homo sapiens	128-132
26906122-5	2016	Based on our comparison of the metabolic profiles of human tissues and cancer cells, we suggest that curcumin might couple with CD44 and that curcumin-CD44(+) coupling at the cell membrane might have some blocking effect on the transport of glutamine into the cells, thus decreasing the glutamine content in the CD44(+) cells and inducing apoptosis.	Curcumin	142-150	CD44 molecule (Indian blood group)	Homo sapiens	151-155
26906122-5	2016	Based on our comparison of the metabolic profiles of human tissues and cancer cells, we suggest that curcumin might couple with CD44 and that curcumin-CD44(+) coupling at the cell membrane might have some blocking effect on the transport of glutamine into the cells, thus decreasing the glutamine content in the CD44(+) cells and inducing apoptosis.	Curcumin	142-150	CD44 molecule (Indian blood group)	Homo sapiens	151-155
26900700-4	2016	In the present study, we tested the ability of two compounds with chaperone-like activity, 4-phenylbutyrate and curcumin, to rescue these ABCB4 mutants by assessing their effects on subcellular localization, protein maturation, and phospholipid efflux capability.	Curcumin	112-120	ATP binding cassette subfamily B member 4	Homo sapiens	138-143
26810315-5	2016	According to results of SAR study, it was found that 4H-pyrimido[2,1-b]benzothiazole derivatives (2e and 2f), pyrazoles (3a, 3b, 3c and 3d) benzylidenes (4d) exhibited better antioxidant activity than curcumin.	Curcumin	201-209	sarcosine dehydrogenase	Homo sapiens	24-27
26691217-9	2016	Induction of CUGBP2 expression by curcumin resulted in the downregulation of HO-1 and COX-2 and strongly sensitized tumor cells to GEM treatment.	Curcumin	34-42	CUGBP Elav-like family member 2	Homo sapiens	13-19
27644631-6	2016	An increased level of caspase-3, apoptosis inducing factor (AIF), cleaved PARP-1 and decreased level of Bcl2 was observed in leukemia cells after 24h of curcumin treatment.	Curcumin	153-161	apoptosis inducing factor mitochondria associated 1	Homo sapiens	33-58
27644631-6	2016	An increased level of caspase-3, apoptosis inducing factor (AIF), cleaved PARP-1 and decreased level of Bcl2 was observed in leukemia cells after 24h of curcumin treatment.	Curcumin	153-161	apoptosis inducing factor mitochondria associated 1	Homo sapiens	60-63
26540017-6	2016	In this tendon injury model, curcumin significantly improved the healing properties as evidenced by extensive deposition of well-organized collagen fibers, decreased MDA levels, and increase in the biomechanical properties and MnSOD activity of the regenerated tendon tissues.	Curcumin	29-37	superoxide dismutase 2	Rattus norvegicus	227-232
26475620-0	2016	Curcumin and hemopressin treatment attenuates cholestasis-induced liver fibrosis in rats: role of CB1 receptors.	Curcumin	0-8	cannabinoid receptor 1	Rattus norvegicus	98-101
26475620-3	2016	The current study aimed to investigate whether CB1 antagonist, hemopressin, could potentiate the hepatoprotective effect of curcumin, in comparison with silymarin in bile duct-ligated (BDL) rats.	Curcumin	124-132	cannabinoid receptor 1	Rattus norvegicus	47-50
26475620-6	2016	However, the combination of hemopressin and curcumin reduced the expression of CB1 in fibrotic liver.	Curcumin	44-52	cannabinoid receptor 1	Rattus norvegicus	79-82
26881029-3	2016	Curcumin upregulated paraoxonase 1 (PON1) mRNA and caused significant increase in serum PON1 and homocysteine thiolactonase activities as compared to high omega-3 PUFA and ethanol group.	Curcumin	0-8	paraoxonase 1	Rattus norvegicus	21-34
26881029-3	2016	Curcumin upregulated paraoxonase 1 (PON1) mRNA and caused significant increase in serum PON1 and homocysteine thiolactonase activities as compared to high omega-3 PUFA and ethanol group.	Curcumin	0-8	paraoxonase 1	Rattus norvegicus	36-40
26881029-3	2016	Curcumin upregulated paraoxonase 1 (PON1) mRNA and caused significant increase in serum PON1 and homocysteine thiolactonase activities as compared to high omega-3 PUFA and ethanol group.	Curcumin	0-8	paraoxonase 1	Rattus norvegicus	88-92
26827953-6	2016	In addition to the high-affinity 1,25D hormone, low-affinity nutritional VDR ligands including curcumin, polyunsaturated fatty acids, and anthocyanidins initiate VDR signaling, whereas the longevity principles resveratrol and SIRT1 potentiate VDR signaling.	Curcumin	95-103	vitamin D receptor	Homo sapiens	73-76
26827953-6	2016	In addition to the high-affinity 1,25D hormone, low-affinity nutritional VDR ligands including curcumin, polyunsaturated fatty acids, and anthocyanidins initiate VDR signaling, whereas the longevity principles resveratrol and SIRT1 potentiate VDR signaling.	Curcumin	95-103	vitamin D receptor	Homo sapiens	162-165
26827953-6	2016	In addition to the high-affinity 1,25D hormone, low-affinity nutritional VDR ligands including curcumin, polyunsaturated fatty acids, and anthocyanidins initiate VDR signaling, whereas the longevity principles resveratrol and SIRT1 potentiate VDR signaling.	Curcumin	95-103	vitamin D receptor	Homo sapiens	162-165
26729105-6	2015	Furthermore, curcumin treatment decreased glial scar formation by decreasing the levels of MIP1alpha, IL-2, and RANTES production and by decreasing NF-kappaB activity.	Curcumin	13-21	C-C motif chemokine ligand 5	Rattus norvegicus	112-118
26633653-4	2015	However, the mZac1-enhanced AP-1 transcriptional activity was suppressed by curcumin, indicating the anti-inflammatory property of this botanical agent and is exhibited by blocking the AP-1-mediated cross-talk between PSORS1 and PSORS4.	Curcumin	76-84	major histocompatibility complex, class I, C	Homo sapiens	218-224
26481552-0	2015	Modulation of Kv2.1 channels inactivation by curcumin.	Curcumin	45-53	potassium voltage-gated channel subfamily B member 1	Homo sapiens	14-19
26481552-1	2015	BACKGROUND: The aim of the present study was to assess the effects of curcumin on the voltage-dependent Kv2.1 potassium channel.	Curcumin	70-78	potassium voltage-gated channel subfamily B member 1	Homo sapiens	104-109
26481552-2	2015	METHODS: The whole-cell patch-clamp technique was used to explore the regulation of Kv2.1 channels expressed in HEK293 cells by curcumin.	Curcumin	128-136	potassium voltage-gated channel subfamily B member 1	Homo sapiens	84-89
26481552-3	2015	RESULTS: Curcumin reduced the Kv2.1 currents; the inhibition occurred with a slow time course and was partially reversible.	Curcumin	9-17	potassium voltage-gated channel subfamily B member 1	Homo sapiens	30-35
26481552-5	2015	Curcumin inhibition of Kv2.1 current was not use-dependent.	Curcumin	0-8	potassium voltage-gated channel subfamily B member 1	Homo sapiens	23-28
26481552-6	2015	CONCLUSIONS: Overall, our data suggest that curcumin inhibits Kv2.1 channels by modulating the inactivation gating, which would be expected to impact cellular physiology.	Curcumin	44-52	potassium voltage-gated channel subfamily B member 1	Homo sapiens	62-67
26130461-8	2015	Profiling MEST and RXRgamma for curcumin and CBB1007, respectively, indicated an inability of curcumin and CBB1007 in restricting residual tumor regenerative capabilities.	Curcumin	32-40	mesoderm specific transcript	Homo sapiens	10-14
26330141-7	2015	Curcumin treatment inhibited palmitate-induced apoptosis, relieved mitochondrial depolarization and up-regulated Bcl-2/Bax ratio.	Curcumin	0-8	BCL2-associated X protein	Mus musculus	119-122
25716014-11	2015	Our study demonstrated that the synergistic antitumor activity of curcumin combined with carboplatin is mediated by multiple mechanisms involving suppression of NF-kappaB via inhibition of the Akt/IKKalpha pathway and enhanced ERK1/2 activity.	Curcumin	66-74	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	197-205
26460892-7	2015	In conclusion, the present study suggested that curcumin-induced necrotic cell death was mediated via a p53-independent molecular pathway, which was associated with Bax and Bak translocation, caspase activation and cytochrome c release.	Curcumin	48-56	BCL2 antagonist/killer 1	Homo sapiens	173-176
26414495-7	2015	Production of reactive oxygen species (ROS) induced by PMA (126.7 +- 2.1%) was markedly attenuated by curcumin, DMC, and BDMC to 99.5 +- 7.8%, 87.8 +- 8.2%, and 89.8 +- 7.6%, respectively, resulting in the down-regulation of CD11b and MMP-9 expression.	Curcumin	102-110	integrin subunit alpha M	Homo sapiens	225-230
26414495-7	2015	Production of reactive oxygen species (ROS) induced by PMA (126.7 +- 2.1%) was markedly attenuated by curcumin, DMC, and BDMC to 99.5 +- 7.8%, 87.8 +- 8.2%, and 89.8 +- 7.6%, respectively, resulting in the down-regulation of CD11b and MMP-9 expression.	Curcumin	102-110	matrix metallopeptidase 9	Homo sapiens	235-240
25331984-0	2015	Inhibition of beta-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo.	Curcumin	44-52	catenin (cadherin associated protein), beta 1	Mus musculus	14-26
25331984-5	2015	A newly synthesized curcumin analog has inhibitory potential against beta-catenin and STAT3.	Curcumin	20-28	catenin (cadherin associated protein), beta 1	Mus musculus	69-81
25331984-11	2015	CONCLUSION: beta-Catenin and STAT3 can be pharmacologically inhibited in vivo with a curcumin analog, which effectively inhibits beta-catenin and STAT3.	Curcumin	85-93	catenin (cadherin associated protein), beta 1	Mus musculus	12-24
25331984-11	2015	CONCLUSION: beta-Catenin and STAT3 can be pharmacologically inhibited in vivo with a curcumin analog, which effectively inhibits beta-catenin and STAT3.	Curcumin	85-93	catenin (cadherin associated protein), beta 1	Mus musculus	129-141
26600714-9	2015	In addition, curcumin increased Nrf2 activation and anti-oxidative genes expressions such as NQO1, HO-1, and SOD through inducing extracellular signal-regulated kinase (ERK) and p38 phosphorylation.	Curcumin	13-21	NAD(P)H dehydrogenase, quinone 1	Mus musculus	93-97
26451117-9	2015	RESULTS: The levels of HIF-1alpha and VEGF, and MVD in tumors of liposomal curcumin TAE-treated group were significantly decreased compared to the TAE-treated group (P&lt;0.05).	Curcumin	75-83	vascular endothelial growth factor A	Oryctolagus cuniculus	38-42
26116834-8	2015	Furthermore, we showed that addition of Curcumin to CML cells caused a downregulation of Bcr-Abl expression through the cellular increase of miR-196b.The effects of Curcumin was then investigated on a CML xenograft in SCID mice.	Curcumin	40-48	microRNA 196b	Mus musculus	141-149
26102194-0	2015	Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells.	Curcumin	0-8	sirtuin 1	Homo sapiens	83-88
26102194-3	2015	In this study, results showed that curcumin dramatically increased the expression of ATP-binding cassette transporter 1 (ABCA1), promoted cholesterol efflux from THP-1 macrophage-derived foam cells, and reduced cellular cholesterol levels.	Curcumin	35-43	ATP binding cassette subfamily A member 1	Homo sapiens	85-119
26102194-3	2015	In this study, results showed that curcumin dramatically increased the expression of ATP-binding cassette transporter 1 (ABCA1), promoted cholesterol efflux from THP-1 macrophage-derived foam cells, and reduced cellular cholesterol levels.	Curcumin	35-43	ATP binding cassette subfamily A member 1	Homo sapiens	121-126
26102194-4	2015	Curcumin activated AMP-activated protein kinase (AMPK) and SIRT1, and then activated LXRalpha in THP-1 macrophage-derived foam cells.	Curcumin	0-8	sirtuin 1	Homo sapiens	59-64
26102194-5	2015	Inhibiting AMPK/SIRT1 activity by its specific inhibitor or by small interfering RNA could inhibit LXRalpha activation and abolish curcumin-induced ABCA1 expression and cholesterol efflux.	Curcumin	131-139	sirtuin 1	Homo sapiens	16-21
26102194-5	2015	Inhibiting AMPK/SIRT1 activity by its specific inhibitor or by small interfering RNA could inhibit LXRalpha activation and abolish curcumin-induced ABCA1 expression and cholesterol efflux.	Curcumin	131-139	ATP binding cassette subfamily A member 1	Homo sapiens	148-153
26102194-6	2015	Thus, curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through activating AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells.	Curcumin	6-14	ATP binding cassette subfamily A member 1	Homo sapiens	59-64
26102194-6	2015	Thus, curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through activating AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells.	Curcumin	6-14	sirtuin 1	Homo sapiens	100-105
25998196-15	2015	Gene expressions of muscle-specific ubiquitin E3 ligase atrogin-1/MAFbx and MuRF1 were increased in DM and inhibited in DM+Curcumin mice.	Curcumin	123-131	tripartite motif-containing 63	Mus musculus	76-81
26299580-0	2015	Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1.	Curcumin	0-8	sirtuin 1	Homo sapiens	98-103
25979368-0	2015	Curcumin potentiates the anti-leukemia effects of imatinib by downregulation of the AKT/mTOR pathway and BCR/ABL gene expression in Ph+ acute lymphoblastic leukemia.	Curcumin	0-8	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	105-112
25979368-6	2015	Here, we reported that curcumin induced apoptosis by inhibition of AKT/mTOR and ABL/STAT5 signaling, down-regulation of BCR/ABL expression, and induction of the BCL2/BAX imbalance.	Curcumin	23-31	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	80-83
25979368-6	2015	Here, we reported that curcumin induced apoptosis by inhibition of AKT/mTOR and ABL/STAT5 signaling, down-regulation of BCR/ABL expression, and induction of the BCL2/BAX imbalance.	Curcumin	23-31	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	120-127
25979368-7	2015	Curcumin exerted synergetic anti-leukemia effects with imatinib by inhibition of the imatinib-mediated overactivation of AKT/mTOR signaling and down-regulation of BCR/ABL gene expression.	Curcumin	0-8	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	163-170
26464676-0	2015	Effect of curcumin on Bcl-2 and Bax expression in nude mice prostate cancer.	Curcumin	10-18	BCL2-associated X protein	Mus musculus	32-35
26464676-3	2015	This study aimed to explore the curcumin induced prostate cancer cell apoptosis and apoptosis related proteins Bcl-2 and Bax expression.	Curcumin	32-40	BCL2-associated X protein	Mus musculus	121-124
26464676-13	2015	Curcumin could inhibit PC-3 growth, decrease tumor volume, reduce tumor weight, and induce cell apoptosis under the skin of nude mice by up-regulating Bax and down-regulating Bcl-2.	Curcumin	0-8	BCL2-associated X protein	Mus musculus	151-154
26059056-13	2015	In conclusion, the PKCalpha/Nox-2/ROS/ATF-2/MMP-9 signaling pathway is activated in lung cancer A549 cells, which could be modulated by curcumin to inhibit cell invasiveness.	Curcumin	136-144	cytochrome b-245 beta chain	Homo sapiens	28-33
26059056-13	2015	In conclusion, the PKCalpha/Nox-2/ROS/ATF-2/MMP-9 signaling pathway is activated in lung cancer A549 cells, which could be modulated by curcumin to inhibit cell invasiveness.	Curcumin	136-144	activating transcription factor 2	Homo sapiens	38-43
26059056-13	2015	In conclusion, the PKCalpha/Nox-2/ROS/ATF-2/MMP-9 signaling pathway is activated in lung cancer A549 cells, which could be modulated by curcumin to inhibit cell invasiveness.	Curcumin	136-144	matrix metallopeptidase 9	Homo sapiens	44-49
25744732-4	2015	We studied the regulation of telomerase and telomerase reverse transcriptase catalytic subunit (TERT) by diclofenac and curcumin, alone and also in combination, in 1, 2-dimethylhydrazine dihydrochloride-induced colorectal cancer in rats.	Curcumin	120-128	telomerase reverse transcriptase	Rattus norvegicus	44-94
25744732-4	2015	We studied the regulation of telomerase and telomerase reverse transcriptase catalytic subunit (TERT) by diclofenac and curcumin, alone and also in combination, in 1, 2-dimethylhydrazine dihydrochloride-induced colorectal cancer in rats.	Curcumin	120-128	telomerase reverse transcriptase	Rattus norvegicus	96-100
26218133-4	2015	Following DNA damage, the Mec1-dependent DNA damage checkpoint is inactivated and Rad52 recombinase is degraded by curcumin, which results in deficiencies in double-stand break repair.	Curcumin	115-123	protein kinase MEC1	Saccharomyces cerevisiae S288C	26-30
25349216-6	2015	Furthermore, curcumin enhances E-cadherin expression, inhibits metalloproteinase-9 (MMP-9) enzyme activity, and weakens K1 cells migration under hypoxic conditions.	Curcumin	13-21	matrix metallopeptidase 9	Homo sapiens	84-89
25060836-6	2015	Curcumin treatment further reduced the blood glucose level (near normal); and accelerated the organ regeneration, enhanced VEGF/PECAM expression and decreased caspase expression level in the organs.	Curcumin	0-8	vascular endothelial growth factor A	Mus musculus	123-127
25060836-8	2015	CONCLUSION: This study suggests that bone marrow transplantation and curcumin administration is an effective treatment in reversing the early onset effects of diabetes via the VEGF/PECAM signaling pathway.	Curcumin	69-77	vascular endothelial growth factor A	Mus musculus	176-180
25823828-0	2015	Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase-1.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	150-166
25823828-8	2015	Further analysis revealed that the expression levels of Nrf2 and HO-1 protein were elevated to a greater extent in the curcumin pretreated NRK-52E cells compared with those of the control.	Curcumin	119-127	heme oxygenase 1	Rattus norvegicus	65-69
25823828-9	2015	Notably, knockdown of Nrf2 with small interfering RNA prevented the curcumin-induced elevation in expression of HO-1 and the associated anti-fibrotic effects.	Curcumin	68-76	heme oxygenase 1	Rattus norvegicus	112-116
25823828-10	2015	In conclusion, the present findings suggested that curcumin may be significant in cellular antioxidant defense, through the activation of Nrf2 and HO-1, thereby protecting the NRK-52E cells from HG-induced EMT.	Curcumin	51-59	heme oxygenase 1	Rattus norvegicus	147-151
25791922-9	2015	Immunohistochemistry showed that curcumin inhibited p-IRE1alpha, p-PERK and NLRP3 expression in hippocampus CA1 region.	Curcumin	33-41	carbonic anhydrase 1	Homo sapiens	108-111
26114940-0	2015	Curcumin Improves Amyloid beta-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway.	Curcumin	0-8	brain-derived neurotrophic factor	Rattus norvegicus	86-90
26309547-0	2015	Curcumin inhibits lung cancer invasion and metastasis by attenuating GLUT1/MT1-MMP/MMP2 pathway.	Curcumin	0-8	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	75-82
26309547-0	2015	Curcumin inhibits lung cancer invasion and metastasis by attenuating GLUT1/MT1-MMP/MMP2 pathway.	Curcumin	0-8	matrix metallopeptidase 2	Mus musculus	83-87
26309547-7	2015	Real-time PCR and Western-blotting were employed to examine the expression levels of GLUT1, membrane type 1-MMP (MT1-MMP) and matrix metalloproteinase (MMP) 2 in curcumin- incubated A549 cells.	Curcumin	162-170	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	92-111
26309547-7	2015	Real-time PCR and Western-blotting were employed to examine the expression levels of GLUT1, membrane type 1-MMP (MT1-MMP) and matrix metalloproteinase (MMP) 2 in curcumin- incubated A549 cells.	Curcumin	162-170	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	113-120
26309547-7	2015	Real-time PCR and Western-blotting were employed to examine the expression levels of GLUT1, membrane type 1-MMP (MT1-MMP) and matrix metalloproteinase (MMP) 2 in curcumin- incubated A549 cells.	Curcumin	162-170	matrix metallopeptidase 2	Mus musculus	126-158
26309547-10	2015	Curcumin inhibited invasion and expressions of GLUT1, MT1-MMP and MMP2 untransfected A549 cells in a concentration-dependent manner.	Curcumin	0-8	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	54-61
26309547-10	2015	Curcumin inhibited invasion and expressions of GLUT1, MT1-MMP and MMP2 untransfected A549 cells in a concentration-dependent manner.	Curcumin	0-8	matrix metallopeptidase 2	Mus musculus	66-70
26309547-11	2015	pcDNA3.1-GLUT1 transfected A549 cells exhibited resistance to curcumin"s anti-invasion effect by up-regulating expressions of GLUT2, MT1-MMP and MMP2.	Curcumin	62-70	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	133-140
26309547-11	2015	pcDNA3.1-GLUT1 transfected A549 cells exhibited resistance to curcumin"s anti-invasion effect by up-regulating expressions of GLUT2, MT1-MMP and MMP2.	Curcumin	62-70	matrix metallopeptidase 2	Mus musculus	145-149
26309547-13	2015	These results suggested that curcumin inhibit lung cancer invasion and metastasis by attenuating GLUT1/MT1-MMP/MMP2 pathway.	Curcumin	29-37	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	103-110
26309547-13	2015	These results suggested that curcumin inhibit lung cancer invasion and metastasis by attenuating GLUT1/MT1-MMP/MMP2 pathway.	Curcumin	29-37	matrix metallopeptidase 2	Mus musculus	111-115
25541467-0	2015	Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase--Carbonyl reductase 1.	Curcumin	0-8	carbonyl reductase 1	Homo sapiens	90-110
25541467-3	2015	In the present study, we report that curcumin is a potent tight-binding inhibitor of human carbonyl reductase 1 (CBR1, Ki=223 nM).	Curcumin	37-45	carbonyl reductase 1	Homo sapiens	91-111
25541467-3	2015	In the present study, we report that curcumin is a potent tight-binding inhibitor of human carbonyl reductase 1 (CBR1, Ki=223 nM).	Curcumin	37-45	carbonyl reductase 1	Homo sapiens	113-117
25541467-5	2015	Molecular modeling supports the finding that curcumin occupies the cofactor binding site of CBR1.	Curcumin	45-53	carbonyl reductase 1	Homo sapiens	92-96
26261481-0	2015	Curcumin inhibits cell proliferation and promotes apoptosis in human osteoclastoma cell through MMP-9, NF-kappaB and JNK signaling pathways.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	96-101
26261481-7	2015	Firstly, MMP-9, NF-kappaB and JNK inhibitors were added into GCT cells and which was researched the mechanism of curcumin on human GCT cells.	Curcumin	113-121	matrix metallopeptidase 9	Homo sapiens	9-14
26261481-9	2015	Furthermore, curcumin inhibited the MMP-9 gene expression quantity and NF-kappaB activity, and activated JNK protein expression in GCT cells.	Curcumin	13-21	matrix metallopeptidase 9	Homo sapiens	36-41
25862641-0	2015	Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2.	Curcumin	0-8	lymphocyte antigen 96	Homo sapiens	118-121
25712055-8	2015	We discovered that curcumin and AKBA induced upregulation of tumor-suppressive miR-34a and downregulation of miR-27a in colorectal cancer cells.	Curcumin	19-27	microRNA 27a	Mus musculus	109-116
25712055-9	2015	Furthermore, we demonstrated in a mouse xenograft model that both curcumin and AKBA treatments suppressed tumor growth, which corresponded with alterations in the expression of miR-34a and miR-27a, consistent with our in vitro findings.	Curcumin	66-74	microRNA 27a	Mus musculus	189-196
26191140-8	2015	Curcumin treatment effectively attenuated TS-triggered activation of ERK1/2, JNK and p38 MAPK pathways, AP-1 proteins and EMT alterations in bladder tissue.	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	77-80
25510836-9	2015	The administration of curcumin at 100 mg/kg during the 12 weeks markedly decreased the expression of PCNA, Bcl-2, SOCS1 e -3, and STAT3.	Curcumin	22-30	proliferating cell nuclear antigen	Rattus norvegicus	101-105
25510836-9	2015	The administration of curcumin at 100 mg/kg during the 12 weeks markedly decreased the expression of PCNA, Bcl-2, SOCS1 e -3, and STAT3.	Curcumin	22-30	suppressor of cytokine signaling 1	Rattus norvegicus	114-119
25856395-5	2015	Curcumin pre-treatment also abrogated the gp120-mediated upregulation of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin (IL)-6, which mediate barrier disruption, as well as the chemokines IL-8, RANTES and interferon gamma-induced protein-10 (IP-10), which are capable of recruiting HIV target cells to the FGT.	Curcumin	0-8	C-C motif chemokine ligand 5	Homo sapiens	221-227
25856395-5	2015	Curcumin pre-treatment also abrogated the gp120-mediated upregulation of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin (IL)-6, which mediate barrier disruption, as well as the chemokines IL-8, RANTES and interferon gamma-induced protein-10 (IP-10), which are capable of recruiting HIV target cells to the FGT.	Curcumin	0-8	C-X-C motif chemokine ligand 10	Homo sapiens	269-274
25682767-3	2015	Here, we report that topical use of a curcumin gel formulation inhibited TPA-induced Th1 inflammation in K14-VEGF transgenic mice ears but not Th17 inflammation as expected.	Curcumin	38-46	vascular endothelial growth factor A	Mus musculus	109-113
25682767-7	2015	In conclusion, curcumin inhibits TPA-induced Th1 inflammation in K14-VEGF transgenic mice which has not been previously described.	Curcumin	15-23	vascular endothelial growth factor A	Mus musculus	69-73
25622075-2	2015	Herein, we first reported the codelivery of sorafenib and curcumin by directed self-assembled nanoparticles (SCN) to enhance the therapeutic effect on HCC.	Curcumin	58-66	sorcin	Homo sapiens	109-112
25622075-3	2015	SCN was formed by employing the hydrophobic interactions among the lipophilic structure in sorafenib, curcumin, and similar hydrophobic segments of polyethylene glycol derivative of vitamin E succinate (PEG-VES), which comprised uniform spherical particles with particle size of 84.97 +- 6.03 nm.	Curcumin	102-110	sorcin	Homo sapiens	0-3
25622075-5	2015	Moreover, the tissue concentration of sorafenib and curcumin in gastrointestinal tract and major organs were significantly improved after their coassembly into SCN.	Curcumin	52-60	sorcin	Homo sapiens	160-163
25444916-0	2015	Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer.	Curcumin	0-8	X-linked inhibitor of apoptosis	Homo sapiens	65-69
25444916-5	2015	miRNA microarray and qPCR indicated that miR-192-5p and miR-215 were the most responsive miRNAs upon curcumin treatment in H460 and A427 cells.	Curcumin	101-109	microRNA 215	Homo sapiens	56-63
24807589-9	2015	Moreover, curcumin increased serotonin, BDNF and pCREB levels in the hippocampus, but they were decreased in the colonic of CAS rats.	Curcumin	10-18	brain-derived neurotrophic factor	Rattus norvegicus	40-44
24807589-11	2015	These results suggested that curcumin exerts the effects on IBS through regulating neurotransmitters, BDNF and CREB signaling both in the brain and peripheral intestinal system.	Curcumin	29-37	brain-derived neurotrophic factor	Rattus norvegicus	102-106
26415414-7	2015	CONCLUSION: Curcumin can decrease cerebral ischemia reperfusion pathological damage significantly and suppressed the expression of MMP-9 and TNF-alpha, and Evans blue dye, brain tissue damage, leukocyte infiltration, which may be involved in protective mechanisms of curcumin.	Curcumin	12-20	matrix metallopeptidase 9	Rattus norvegicus	131-136
26163620-6	2015	On the contrary, HCC groups treated with either curcumin or carvacrol showed significant downregulation in AR and ERalpha gene expression levels in the liver tissue.	Curcumin	48-56	androgen receptor	Rattus norvegicus	107-109
26415702-8	2015	Some polyphenols (e.g. luteolin, apigenin and curcumin) have been shown to be very potent CBR1 inhibitors.	Curcumin	46-54	carbonyl reductase 1	Homo sapiens	90-94
26170881-0	2015	Curcumin Protects Neurons from Glutamate-Induced Excitotoxicity by Membrane Anchored AKAP79-PKA Interaction Network.	Curcumin	0-8	A-kinase anchoring protein 5	Homo sapiens	85-91
26170881-5	2015	In this study, we found that curcumin protected neurons from glutamate insult by reducing Ca(2+) influx and blocking the translocation of AKAP79 from cytomembrane to cytoplasm.	Curcumin	29-37	A-kinase anchoring protein 5	Homo sapiens	138-144
26170881-8	2015	In conclusion, our results show that AKAP79-anchored PKA facilitated the signal relay from AMPA receptor to AKT and ERK cascades, which may be crucial for curcumin-mediated antiexcitotoxicity.	Curcumin	155-163	A-kinase anchoring protein 5	Homo sapiens	37-43
26333125-7	2015	Hypomethylation of p15 was further found to be favoured by downregulation of DNA methyltransferase 1 after 10 muM curcumin treatment for six days.	Curcumin	114-122	DNA methyltransferase 1	Homo sapiens	77-100
26333125-10	2015	Reverse-transcription PCR demonstrated that treatment with curcumin (10 muM) for six days led to the up-regulation of p15 and down-regulation of DNA methyltransferase 1.	Curcumin	59-67	DNA methyltransferase 1	Homo sapiens	145-168
26333125-11	2015	Furthermore, curcumin- mediated reversal of p15 promoter methylation might be potentiated by down-regulation of DNA methyltransferase 1 expression, which was supported by cell cycle analysis.	Curcumin	13-21	DNA methyltransferase 1	Homo sapiens	112-135
25526714-6	2015	After 24 h of intranasal LPS instillation, a marked increase in neutrophil recruitment and myeloperoxidase (MPO) activity was noted which were significantly ameliorated in curcumin treatment group.	Curcumin	172-180	myeloperoxidase	Mus musculus	91-106
25526714-6	2015	After 24 h of intranasal LPS instillation, a marked increase in neutrophil recruitment and myeloperoxidase (MPO) activity was noted which were significantly ameliorated in curcumin treatment group.	Curcumin	172-180	myeloperoxidase	Mus musculus	108-111
26328442-9	2015	Therefore, chitosan-coated PCL nanoparticles may be considered a promising strategy to deliver curcumin directly into the oral cavity for the treatment of oral cancer.	Curcumin	95-103	PHD finger protein 1	Homo sapiens	27-30
26053510-7	2015	Curcumin inhibits Abeta-induced increase of cellular Ca(2+) and depresses Abeta-induced phosphorylations of both NMDA receptor and cyclic AMP response element-binding protein (CREB) and activating transcription factor 1 (ATF-1).	Curcumin	0-8	cAMP responsive element binding protein 1	Homo sapiens	131-174
26053510-7	2015	Curcumin inhibits Abeta-induced increase of cellular Ca(2+) and depresses Abeta-induced phosphorylations of both NMDA receptor and cyclic AMP response element-binding protein (CREB) and activating transcription factor 1 (ATF-1).	Curcumin	0-8	cAMP responsive element binding protein 1	Homo sapiens	176-180
25435978-9	2015	Curcumin and the VEGF blocker are each capable of inhibiting hepatocellular carcinoma progression by regulating the VEGF/VEGFR/K-ras pathway.	Curcumin	0-8	KRAS proto-oncogene, GTPase	Rattus norvegicus	127-132
25179440-6	2014	Furthermore, curcumin induces decrease in haet shock protein (Hsp)60 and hexokinase II mitochondrial protein levels and increase in the pro-apoptotic protein, bcl-2 associated death promoter (BAD).	Curcumin	13-21	heat shock protein family D (Hsp60) member 1	Homo sapiens	62-68
25179295-0	2014	Inactivation of FoxM1 transcription factor contributes to curcumin-induced inhibition of survival, angiogenesis, and chemosensitivity in acute myeloid leukemia cells.	Curcumin	58-66	forkhead box M1	Homo sapiens	16-21
25179295-5	2014	We also found that specific downregulation of FoxM1 by siRNA prior to curcumin treatment resulted in enhanced cell survival inhibition and induction of apoptosis.	Curcumin	70-78	forkhead box M1	Homo sapiens	46-51
25179295-7	2014	More importantly, curcumin suppressed FoxM1 expression, selectively inhibited cell survival as well as the combination of curcumin and doxorubicin exhibited a more inhibitory effect in primary CD34(+) AML cells, while showing limited lethality in normal CD34(+) hematopoietic progenitors.	Curcumin	18-26	forkhead box M1	Homo sapiens	38-43
25179295-8	2014	These results identify a novel role for FoxM1 in mediating the biological effects of curcumin in human AML cells.	Curcumin	85-93	forkhead box M1	Homo sapiens	40-45
25179295-12	2014	Inactivation of FoxM1 contributes to curcumin-induced anti-leukemic effects.	Curcumin	37-45	forkhead box M1	Homo sapiens	16-21
25530715-8	2014	RESULTS: We demonstrated MCF-7 and MDA-MB-231 cells exhibited differential responses to curcumin by WST-1 and clonogenic assay (MDA-MB-231 cells was sensitive, and MCF-7 cells was resistant), which were found to be related to the differential curcumin-mediated regulation of SKP2-Cip/Kips (p21 and p27 but not p57) signaling.	Curcumin	88-96	muscular LMNA interacting protein	Homo sapiens	280-283
25530715-12	2014	CONCLUSIONS: Our study established PI3K/Akt-SKP2-Cip/Kips signaling pathway is involved in the mechanism of action of curcumin and revealed that the discrepant modulation of this pathway by curcumin is responsible for the differential susceptibilities of these two cell types to curcumin.	Curcumin	118-126	muscular LMNA interacting protein	Homo sapiens	49-52
25406541-6	2014	FINDINGS: Here we report that curcumin (CUR), a naturally occurring compound endowed with p300/CREB-binding protein HAT inhibitory activity, is able to induce a drastic down-regulation of the mGlu2 receptor in the mouse spinal cord after systemic administration together with a marked hypoacetylation of histones H3 and H4 in dorsal root ganglia (DRG).	Curcumin	30-38	E1A binding protein p300	Mus musculus	90-94
25406541-6	2014	FINDINGS: Here we report that curcumin (CUR), a naturally occurring compound endowed with p300/CREB-binding protein HAT inhibitory activity, is able to induce a drastic down-regulation of the mGlu2 receptor in the mouse spinal cord after systemic administration together with a marked hypoacetylation of histones H3 and H4 in dorsal root ganglia (DRG).	Curcumin	30-38	CREB binding protein	Mus musculus	95-115
25268984-3	2014	MetS was induced in rats by fructose drinking for 12weeks while HO-1 was induced by hemin or curcumin administration in the last 6weeks.	Curcumin	93-101	heme oxygenase 1	Rattus norvegicus	64-68
25268984-8	2014	While not affected by MetS, HO-1 expression was significantly increased by hemin and curcumin treatment.	Curcumin	85-93	heme oxygenase 1	Rattus norvegicus	28-32
24474673-9	2014	In addition, the administration of curcumin significantly decreased the positive expressions of NF-kappa B p65 and CX3CR1 in spinal cord and DRG (P&lt;0.05).	Curcumin	35-43	C-X3-C motif chemokine receptor 1	Rattus norvegicus	115-121
24474673-10	2014	CONCLUSION: Our study suggests that curcumin could ameliorate the CCI-induced neuropathic pain, probably through inhibiting CX3CR1 expression by the activation of NF-kappa B p65 in spinal cord and DRG.	Curcumin	36-44	C-X3-C motif chemokine receptor 1	Rattus norvegicus	124-130
25195681-5	2014	Curcumin also decreased the expression and activity of matrix metalloproteinases (MMP)-2 and MMP-9, and reduced p38 phosphorylation.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	93-98
25195681-6	2014	Combination treatment of HCC cells with curcumin and SB203580 (a p38 signaling pathway inhibitor), generated a synergistic effect on the expression of MMP-2 and MMP-9, suggesting that the anti-metastatic effect of curcumin on HCC may involve a p38 signaling pathway.	Curcumin	40-48	matrix metallopeptidase 9	Homo sapiens	161-166
25195681-6	2014	Combination treatment of HCC cells with curcumin and SB203580 (a p38 signaling pathway inhibitor), generated a synergistic effect on the expression of MMP-2 and MMP-9, suggesting that the anti-metastatic effect of curcumin on HCC may involve a p38 signaling pathway.	Curcumin	214-222	matrix metallopeptidase 9	Homo sapiens	161-166
25382970-0	2014	Curcumin could reduce the monomer of TTR with Tyr114Cys mutation via autophagy in cell model of familial amyloid polyneuropathy.	Curcumin	0-8	transthyretin	Homo sapiens	37-40
25382970-4	2014	Treatment with curcumin resulted in a significant decrease of monomeric TTR by recovering autophagy.	Curcumin	15-23	transthyretin	Homo sapiens	72-75
25315241-10	2014	In contrast, curcumin inhibits beta-catenin nuclear translocation, thus impeding trans-activation of Slug.	Curcumin	13-21	snail family transcriptional repressor 2	Homo sapiens	101-105
25201116-6	2014	Furthermore, curcumin also inhibited the SCI-associated aquaporin - 4 (AQP4) overexpression and glial fibrillary acidic protein (GFAP) and repressed the unusual activation of the JAK/STAT signaling pathway.	Curcumin	13-21	glial fibrillary acidic protein	Rattus norvegicus	96-127
25201116-6	2014	Furthermore, curcumin also inhibited the SCI-associated aquaporin - 4 (AQP4) overexpression and glial fibrillary acidic protein (GFAP) and repressed the unusual activation of the JAK/STAT signaling pathway.	Curcumin	13-21	glial fibrillary acidic protein	Rattus norvegicus	129-133
25201116-7	2014	In conclusion, our data demonstrate that curcumin exhibits a moderately protective effect on spinal cord injury, and this effect might be related to the inhibition of overexpressed AQP4 and GFAP and the activated JAK/STAT signaling pathway.	Curcumin	41-49	glial fibrillary acidic protein	Rattus norvegicus	190-194
25211173-0	2014	Effect of curcumin on hepatic heme oxygenase 1 expression in high fat diet fed rats: is there a triangular relationship?	Curcumin	10-18	heme oxygenase 1	Rattus norvegicus	30-46
25211173-3	2014	In this study, we investigated the effect of curcumin treatment on hepatic heme oxygenase-1 (HO-1) expression along with pro-oxidant-antioxidant status and lipid accumulation in rats fed an HFD.	Curcumin	45-53	heme oxygenase 1	Rattus norvegicus	75-91
25251395-0	2014	Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet-induced atherosclerosis and glucose intolerance in LDLR-/- mice--role of intestinal permeability and macrophage activation.	Curcumin	56-64	low density lipoprotein receptor	Mus musculus	140-144
25251395-6	2014	Selective gut decontamination and supplementation with curcumin significantly attenuated the WD-induced increase in plasma LPS levels (3.32 vs 1.90 or 1.51 EU/ml, respectively) and improved intestinal barrier function at multiple levels (restoring intestinal alkaline phosphatase activity and expression of tight junction proteins, ZO-1 and Claudin-1).	Curcumin	55-63	claudin 1	Mus musculus	341-350
25072100-4	2014	Curcumin was conjugated as an ester to cholesteryl-hyaluronic acid (CHA) nanogel that is capable of targeted delivery to CD44-expressing drug-resistant cancer cells.	Curcumin	0-8	CD44 molecule (Indian blood group)	Homo sapiens	121-125
25202058-7	2014	Curcumin induced a strong increase in caspase-3/7 activity at 30-40 muM.	Curcumin	0-8	caspase 3	Mus musculus	38-47
24970744-5	2014	Curcumin promoted post-ischemic blood recirculation and suppressed lung cancer progression in inbred C57BL/6 mice via regulation of the HIF1alpha/mTOR/VEGF/VEGFR cascade oppositely.	Curcumin	0-8	vascular endothelial growth factor A	Mus musculus	151-155
24970744-8	2014	Curcumin had opposite effects on blood vessel regeneration under physiological and pathological angiogenesis, which was effected through negative or positive regulation of the HIF1alpha/mTOR/VEGF/VEGFR cascade.	Curcumin	0-8	vascular endothelial growth factor A	Mus musculus	191-195
24984268-2	2014	In this study, we developed folate-modified curcumin (Cur) loaded micelles (Cur-FPPs) for cancer chemotherapy.	Curcumin	44-52	farnesyl diphosphate synthase	Homo sapiens	80-84
25170806-3	2014	We also demonstrated that lentivirus-based knockdown of KLF5 inhibited cancer cell growth, while over-expression of a Flag-tagged KLF5 could partially reverse the effects of curcumin on cell growth and cyclin D1 expression.	Curcumin	174-182	cyclin D1	Mus musculus	202-211
25016646-8	2014	Western blotting study revealed that the induction apoptosis of S-65 cancer cells by curcumin micelles was mainly due to the down-regulation of p-Rb, Blc-2, p-AKT expression and caspase-9 activation.	Curcumin	85-93	RB transcriptional corepressor 1	Mus musculus	144-148
25051175-8	2014	Furthermore, curcumin, a natural selective inhibitor of p300 in HATs, significantly suppressed the expression of PS1 and BACE1 through inhibition of H3 acetylation in their promoter regions in N2a/APPswe cells.	Curcumin	13-21	E1A binding protein p300	Mus musculus	56-60
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	Curcumin	79-87	lecithin cholesterol acyltransferase	Rattus norvegicus	207-243
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	Curcumin	79-87	lecithin cholesterol acyltransferase	Rattus norvegicus	245-249
24779927-7	2014	Further investigations showed that curcumin inhibited VEGF expression in HSCs associated with disrupting platelet-derived growth factor-beta receptor (PDGF-betaR)/ERK and mTOR pathways.	Curcumin	35-43	mechanistic target of rapamycin kinase	Rattus norvegicus	171-175
24779927-8	2014	HSC motility and vascularization were also suppressed by curcumin associated with blocking PDGF-betaR/focal adhesion kinase/RhoA cascade.	Curcumin	57-65	ras homolog family member A	Rattus norvegicus	124-128
24779927-9	2014	Gain- or loss-of-function analyses revealed that activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) was required for curcumin to inhibit angiogenic properties of HSCs.	Curcumin	142-150	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	63-111
24779927-9	2014	Gain- or loss-of-function analyses revealed that activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) was required for curcumin to inhibit angiogenic properties of HSCs.	Curcumin	142-150	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	113-123
24779927-10	2014	We concluded that curcumin attenuated sinusoidal angiogenesis in liver fibrosis possibly by targeting HSCs via a PPAR-gamma activation-dependent mechanism.	Curcumin	18-26	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	113-123
23024111-11	2014	Accordingly, this study suggests that the reduction in oxidative stress and modulation of HO-1 mRNA expression and TNF-alpha release by curcumin and quercetin may contribute to the synergistic anti-inflammatory effects of these two flavonoids upon combination.	Curcumin	136-144	heme oxygenase 1	Rattus norvegicus	90-94
24642369-7	2014	Furthermore, curcumin obviously up-regulated hippocampal brain derived neurotrophic factor (BDNF), TrkB, phosphatidylinositide 3-kinases (PI3K) protein expressions, respectively as shown in Western blot analysis.	Curcumin	13-21	brain-derived neurotrophic factor	Rattus norvegicus	57-90
24642369-7	2014	Furthermore, curcumin obviously up-regulated hippocampal brain derived neurotrophic factor (BDNF), TrkB, phosphatidylinositide 3-kinases (PI3K) protein expressions, respectively as shown in Western blot analysis.	Curcumin	13-21	brain-derived neurotrophic factor	Rattus norvegicus	92-96
24642369-8	2014	These findings demonstrated that curcumin mediated the neuroprotection against 6-OHDA-induced hippocampus neurons in rats, which the underlying mechanism is involved in activating BDNF/TrkB-dependent pathway for promoting neural regeneration of hippocampal tissue.	Curcumin	33-41	brain-derived neurotrophic factor	Rattus norvegicus	180-184
24793851-1	2014	A cold column trapping-cloud point extraction (CCT-CPE) method coupled to high performance liquid chromatography (HPLC) was developed for preconcentration and determination of curcumin in human urine.	Curcumin	176-184	CCT	Homo sapiens	47-50
24626093-0	2014	Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA.	Curcumin	0-8	doublecortin like kinase 1	Homo sapiens	99-104
24626093-2	2014	Here, we report that curcumin promotes the survival of DCLK1-positive colon CSCs, potentially confounding application of its anticancer properties.	Curcumin	21-29	doublecortin like kinase 1	Homo sapiens	55-60
24626093-3	2014	At optimal concentrations, curcumin greatly reduced expression levels of stem cell markers (DCLK1/CD44/ALDHA1/Lgr5/Nanog) in three-dimensional spheroid cultures and tumor xenografts derived from colon cancer cells.	Curcumin	27-35	doublecortin like kinase 1	Homo sapiens	92-97
24626093-3	2014	At optimal concentrations, curcumin greatly reduced expression levels of stem cell markers (DCLK1/CD44/ALDHA1/Lgr5/Nanog) in three-dimensional spheroid cultures and tumor xenografts derived from colon cancer cells.	Curcumin	27-35	CD44 molecule (Indian blood group)	Homo sapiens	98-102
24626093-3	2014	At optimal concentrations, curcumin greatly reduced expression levels of stem cell markers (DCLK1/CD44/ALDHA1/Lgr5/Nanog) in three-dimensional spheroid cultures and tumor xenografts derived from colon cancer cells.	Curcumin	27-35	Nanog homeobox	Homo sapiens	115-120
24626093-4	2014	However, curcumin unexpectedly induced proliferation and autophagic survival of a subset of DCLK1-positive CSCs.	Curcumin	9-17	doublecortin like kinase 1	Homo sapiens	92-97
24626093-6	2014	Notably, RNA interference-mediated silencing of DCLK1 triggered apoptotic cell death of colon cancer cells in vitro and in vivo, and abolished colorectal cancer survival in response to curcumin; combination of DCLK1-siRNA and curcumin dramatically reversed CSC phenotype, contributing to attenuation of the growth of spheroid cultures and tumor xenografts.	Curcumin	185-193	doublecortin like kinase 1	Homo sapiens	48-53
24626093-6	2014	Notably, RNA interference-mediated silencing of DCLK1 triggered apoptotic cell death of colon cancer cells in vitro and in vivo, and abolished colorectal cancer survival in response to curcumin; combination of DCLK1-siRNA and curcumin dramatically reversed CSC phenotype, contributing to attenuation of the growth of spheroid cultures and tumor xenografts.	Curcumin	226-234	doublecortin like kinase 1	Homo sapiens	48-53
24626093-7	2014	Taken together, our findings confirm a role of DCLK1 in colon CSCs and highlight DCLK1 as a target to enhance antitumor properties of curcumin.	Curcumin	134-142	doublecortin like kinase 1	Homo sapiens	81-86
24297305-0	2014	Chronic curcumin treatment normalizes depression-like behaviors in mice with mononeuropathy: involvement of supraspinal serotonergic system and GABAA receptor.	Curcumin	8-16	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	144-149
24297305-10	2014	CONCLUSION: Curcumin can normalize the depressive-like behaviors of neuropathic mice, which may be independent of the concurrent analgesic action and possibly mediated via the supraspinal serotonergic system and downstream GABAA receptor.	Curcumin	12-20	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	223-228
24815146-0	2014	Curcumin attenuates liver warm ischemia and reperfusion-induced combined restrictive and obstructive lung disease by reducing matrix metalloprotease 9 activity.	Curcumin	0-8	matrix metallopeptidase 9	Rattus norvegicus	126-150
24815146-11	2014	In addition, curcumin treatment reduced serum ALT level and degrees of TNF-alpha level and MMP-9 activity in the lungs.	Curcumin	13-21	matrix metallopeptidase 9	Rattus norvegicus	91-96
24815146-12	2014	CONCLUSIONS: Curcumin attenuated hepatic I/R-induced combined restrictive and obstructive lung disease by reducing lung inflammation and MMP-9 activity.	Curcumin	13-21	matrix metallopeptidase 9	Rattus norvegicus	137-142
25169090-9	2014	Both paraquat group and curcumin intervention group showed increase in MDA content, decreases in SOD and CAT activities, increases in HO-1 and NQO-1 activities, and increases in the protein and mRNA levels of Nrf2, in comparison with the control group (P &lt; 0.05 for all except HO-1 activity in paraquat group on day 7).	Curcumin	24-32	heme oxygenase 1	Rattus norvegicus	134-138
25169090-9	2014	Both paraquat group and curcumin intervention group showed increase in MDA content, decreases in SOD and CAT activities, increases in HO-1 and NQO-1 activities, and increases in the protein and mRNA levels of Nrf2, in comparison with the control group (P &lt; 0.05 for all except HO-1 activity in paraquat group on day 7).	Curcumin	24-32	heme oxygenase 1	Rattus norvegicus	280-284
25169090-10	2014	In comparison with the parquet group on the same day, the curcumin intervention group showed decrease in MDA content, increases in the activities of SOD, CAT, HO-1, and NQO-1, and increases in the mRNA and protein levels of Nrf2 on days 1, 3, and 7 (P &lt; 0.05).	Curcumin	58-66	heme oxygenase 1	Rattus norvegicus	159-163
24534491-6	2014	The inhibitory effect of curcumin on DLK1 expression may be mediated in part by interruption of Shh signaling pathway, which contributes to the promotion effect of curcumin on the expression of PPAR-gamma, a key factor in inhibiting HSC activation.	Curcumin	25-33	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	194-204
24534491-6	2014	The inhibitory effect of curcumin on DLK1 expression may be mediated in part by interruption of Shh signaling pathway, which contributes to the promotion effect of curcumin on the expression of PPAR-gamma, a key factor in inhibiting HSC activation.	Curcumin	164-172	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	194-204
23666561-12	2014	Cleaved PARP and TUNEL staining increased significantly with curcumin administration, indicating the induction of apoptosis.	Curcumin	61-69	poly (ADP-ribose) polymerase family, member 1	Mus musculus	8-12
24949215-0	2014	Curcumin Inhibits Prostate Cancer Bone Metastasis by Up-Regulating Bone Morphogenic Protein-7 in Vivo.	Curcumin	0-8	bone morphogenetic protein 7	Homo sapiens	67-93
24949215-7	2014	Our results strongly suggest that curcumin modulates the TGF-beta signaling that occurs due to bone matrix degradation by up-regulating the metastasis inhibitory bone morphogenic protein-7 (BMP- 7).	Curcumin	34-42	bone morphogenetic protein 7	Homo sapiens	162-188
24949215-7	2014	Our results strongly suggest that curcumin modulates the TGF-beta signaling that occurs due to bone matrix degradation by up-regulating the metastasis inhibitory bone morphogenic protein-7 (BMP- 7).	Curcumin	34-42	bone morphogenetic protein 7	Homo sapiens	190-196
24288129-5	2014	Curcumin stimulated the release of cholesterol and the lysosomal beta-hexosaminidase enzyme, as well as the exosome markers, flotillin-2 and CD63.	Curcumin	0-8	flotillin 2	Homo sapiens	125-136
24737429-0	2014	Effects of curcumin on hippocampal expression of NgR and axonal regeneration in Abeta-induced cognitive disorder rats.	Curcumin	11-19	amyloid beta precursor protein	Rattus norvegicus	80-85
24431405-8	2014	We also demonstrate that curcumin-mediated caspase-1 activation is oxidant dependent by using N-acetyl-L-cysteine (NAC) to inhibit pyroptosis.	Curcumin	25-33	X-linked Kx blood group	Homo sapiens	115-118
24342046-9	2014	Curcumin treatment greatly decreased the levels of c-Jun, c-Fos, SphK1, and FN in the kidney tissues of diabetic rats.	Curcumin	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-63
24342046-9	2014	Curcumin treatment greatly decreased the levels of c-Jun, c-Fos, SphK1, and FN in the kidney tissues of diabetic rats.	Curcumin	0-8	sphingosine kinase 1	Rattus norvegicus	65-70
24476477-0	2014	Effects of curcumin on brain-derived neurotrophic factor levels and oxidative damage in obesity and diabetes.	Curcumin	11-19	brain derived neurotrophic factor	Homo sapiens	23-56
24476477-5	2014	Curcumin improved or restored BDNF levels to normal levels in DM, but curcumin did not have any effect on BDNF levels in sera of obese humans.	Curcumin	0-8	brain derived neurotrophic factor	Homo sapiens	30-34
24415068-8	2014	The analysis on anion transport markers (OAT1 and OAT3) showed a similar trend (CDF &gt; curcumin).	Curcumin	89-97	solute carrier family 22 member 6	Rattus norvegicus	41-45
24445042-0	2014	Curcumin inhibits lung cancer cell migration and invasion through Rac1-dependent signaling pathway.	Curcumin	0-8	Rac family small GTPase 1	Homo sapiens	66-70
24445042-6	2014	Meanwhile, we demonstrated that the suppression of invasiveness correlated with inhibition of Rac1/PAK1 signaling pathways and matrix metalloproteinase (MMP) 2 and 9 protein expression by combining curcumin treatment with the methods of Rac1 gene silence and overexpression in lung cancer cells.	Curcumin	198-206	Rac family small GTPase 1	Homo sapiens	94-98
24445042-7	2014	Laser confocal microscope also showed that Rac1-regulated actin cytoskeleton rearrangement may be involved in anti-invasion effect of curcumin on lung cancer cell.	Curcumin	134-142	Rac family small GTPase 1	Homo sapiens	43-47
24445042-8	2014	At last, through xenograft experiments, we confirmed the connection between Rac1 and the growth and metastasis inhibitory effect of curcumin in vivo.	Curcumin	132-140	Rac family small GTPase 1	Homo sapiens	76-80
24445042-9	2014	In summary, these data demonstrated that low-toxic levels of curcumin could efficiently inhibit migration and invasion of lung cancer cells through inhibition of Rac1/PAK1 signaling pathway and MMP-2 and MMP-9 expression, which provided a novel insight into the molecular mechanism of curcumin against lung cancer.	Curcumin	61-69	Rac family small GTPase 1	Homo sapiens	162-166
24445042-9	2014	In summary, these data demonstrated that low-toxic levels of curcumin could efficiently inhibit migration and invasion of lung cancer cells through inhibition of Rac1/PAK1 signaling pathway and MMP-2 and MMP-9 expression, which provided a novel insight into the molecular mechanism of curcumin against lung cancer.	Curcumin	61-69	matrix metallopeptidase 9	Homo sapiens	204-209
24287376-0	2014	Curcumin promotes neurite outgrowth via reggie-1/flotillin-2 in cortical neurons.	Curcumin	0-8	flotillin 2	Homo sapiens	49-60
24465712-0	2014	pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1).	Curcumin	78-86	cortactin	Homo sapiens	8-17
24465712-5	2014	Curcumin (diferulolylmethane), a natural compound with promising chemopreventive and chemosensitizing effects, reduced the indirect association of cortactin with the plasma membrane protein fraction in colon adenocarcinoma cells as measured by surface biotinylation, mass spectrometry, and Western blotting.	Curcumin	0-8	cortactin	Homo sapiens	147-156
24465712-6	2014	Curcumin significantly decreased the pTyr(421)-CTTN in HCT116 cells and SW480 cells, but was ineffective in HT-29 cells.	Curcumin	0-8	cortactin	Homo sapiens	47-51
24465712-7	2014	Curcumin physically interacted with PTPN1 tyrosine phosphatases to increase its activity and lead to dephosphorylation of pTyr(421)-CTTN.	Curcumin	0-8	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	36-41
24465712-7	2014	Curcumin physically interacted with PTPN1 tyrosine phosphatases to increase its activity and lead to dephosphorylation of pTyr(421)-CTTN.	Curcumin	0-8	cortactin	Homo sapiens	132-136
24465712-8	2014	PTPN1 inhibition eliminated the effects of curcumin on pTyr(421)-CTTN.	Curcumin	43-51	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	0-5
24465712-8	2014	PTPN1 inhibition eliminated the effects of curcumin on pTyr(421)-CTTN.	Curcumin	43-51	cortactin	Homo sapiens	65-69
24465712-10	2014	Curcumin decreased migration of HCT116 and SW480 cells which highly express PTPN1, but not of HT-29 cells with significantly reduced endogenous expression of PTPN1.	Curcumin	0-8	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	76-81
24465712-11	2014	Curcumin significantly reduced the physical interaction of CTTN and pTyr(421)-CTTN with p120 catenin (CTNND1).	Curcumin	0-8	cortactin	Homo sapiens	59-63
24465712-11	2014	Curcumin significantly reduced the physical interaction of CTTN and pTyr(421)-CTTN with p120 catenin (CTNND1).	Curcumin	0-8	cortactin	Homo sapiens	78-82
24465712-12	2014	Collectively, these data suggest that curcumin is an activator of PTPN1 and can reduce cell motility in colon cancer via dephosphorylation of pTyr(421)-CTTN which could be exploited for novel therapeutic approaches in colon cancer therapy based on tumor pTyr(421)-CTTN expression.	Curcumin	38-46	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	66-71
24465712-12	2014	Collectively, these data suggest that curcumin is an activator of PTPN1 and can reduce cell motility in colon cancer via dephosphorylation of pTyr(421)-CTTN which could be exploited for novel therapeutic approaches in colon cancer therapy based on tumor pTyr(421)-CTTN expression.	Curcumin	38-46	cortactin	Homo sapiens	152-156
24465712-12	2014	Collectively, these data suggest that curcumin is an activator of PTPN1 and can reduce cell motility in colon cancer via dephosphorylation of pTyr(421)-CTTN which could be exploited for novel therapeutic approaches in colon cancer therapy based on tumor pTyr(421)-CTTN expression.	Curcumin	38-46	cortactin	Homo sapiens	264-268
24291100-7	2014	Treatment with leflunomide, perindopril or curcumin alone abrogated the DEN-induced increased MVD as well as the elevated expression of VEGF, while only curcumin inhibited HIF-1alpha hepatic expression.	Curcumin	43-51	vascular endothelial growth factor A	Mus musculus	136-140
25292057-5	2014	We also found that KLF4 had synergistic effects with curcumin, better promoting apoptosis and inhibiting proliferation and invasion of gastric carcinona cells.	Curcumin	53-61	Kruppel like factor 4	Homo sapiens	19-23
24401215-0	2014	Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice.	Curcumin	0-8	low density lipoprotein receptor	Mus musculus	84-96
24401215-4	2014	Thus, this study aimed to further elucidate the impact of increasing doses of curcumin on modulation of these molecular mediators on high fat diet-induced atherogenesis, inflammation, and steatohepatosis in Ldlr(-/-) mice.	Curcumin	78-86	low density lipoprotein receptor	Mus musculus	207-211
24401215-18	2014	CONCLUSION: Curcumin through a series of complex mechanisms, alleviated the adverse effects of high fat diet on weight gain, fatty liver development, dyslipidemia, expression of inflammatory cytokines and atherosclerosis in Ldlr(-/-) mouse model of human atherosclerosis.	Curcumin	12-20	low density lipoprotein receptor	Mus musculus	224-228
25054130-0	2014	Molecular mechanisms of curcumin on diabetes-induced endothelial dysfunctions: Txnip, ICAM-1, and NOX2 expressions.	Curcumin	24-32	thioredoxin interacting protein	Rattus norvegicus	79-84
25054130-0	2014	Molecular mechanisms of curcumin on diabetes-induced endothelial dysfunctions: Txnip, ICAM-1, and NOX2 expressions.	Curcumin	24-32	intercellular adhesion molecule 1	Rattus norvegicus	86-92
25054130-0	2014	Molecular mechanisms of curcumin on diabetes-induced endothelial dysfunctions: Txnip, ICAM-1, and NOX2 expressions.	Curcumin	24-32	cytochrome b-245 beta chain	Rattus norvegicus	98-102
25054130-1	2014	We aim to investigate the effects of curcumin on preventing diabetes-induced vascular inflammation in association with its actions on Txnip, ICAM-1, and NOX2 enzyme expressions.	Curcumin	37-45	thioredoxin interacting protein	Rattus norvegicus	134-139
25054130-1	2014	We aim to investigate the effects of curcumin on preventing diabetes-induced vascular inflammation in association with its actions on Txnip, ICAM-1, and NOX2 enzyme expressions.	Curcumin	37-45	intercellular adhesion molecule 1	Rattus norvegicus	141-147
25054130-1	2014	We aim to investigate the effects of curcumin on preventing diabetes-induced vascular inflammation in association with its actions on Txnip, ICAM-1, and NOX2 enzyme expressions.	Curcumin	37-45	cytochrome b-245 beta chain	Rattus norvegicus	153-157
25054130-10	2014	It suggested that curcumin could ameliorate diabetic vascular inflammation by decreasing ROS overproduction, reducing leukocyte-endothelium interaction, and inhibiting ICAM-1 and NOX2 expression.	Curcumin	18-26	intercellular adhesion molecule 1	Rattus norvegicus	168-174
25054130-10	2014	It suggested that curcumin could ameliorate diabetic vascular inflammation by decreasing ROS overproduction, reducing leukocyte-endothelium interaction, and inhibiting ICAM-1 and NOX2 expression.	Curcumin	18-26	cytochrome b-245 beta chain	Rattus norvegicus	179-183
24596618-3	2014	Curcumin inhibited cyclooxygenase-2 (COX-2) dependent prostaglandin D2 (PGD2) and 5-lipoxygenase (5-LO) dependent leukotriene C4 (LTC4) generation dose-dependently in BMMCs.	Curcumin	0-8	prostaglandin D2 synthase (brain)	Mus musculus	54-70
24596618-3	2014	Curcumin inhibited cyclooxygenase-2 (COX-2) dependent prostaglandin D2 (PGD2) and 5-lipoxygenase (5-LO) dependent leukotriene C4 (LTC4) generation dose-dependently in BMMCs.	Curcumin	0-8	arachidonate 5-lipoxygenase	Mus musculus	82-96
24596618-4	2014	To probe the mechanism involved, we assessed the effects of curcumin on the phosphorylation of Syk and its downstream signal molecules.	Curcumin	60-68	spleen tyrosine kinase	Mus musculus	95-98
24596618-5	2014	Curcumin inhibited intracellular Ca(2+) influx via phospholipase Cgamma1 (PLCgamma1) activation and the phosphorylation of mitogen-activated protein kinases (MAPKs) and the nuclear factor-kappaB (NF-kappaB) pathway.	Curcumin	0-8	phospholipase C, gamma 1	Mus musculus	74-83
24868317-9	2014	Curcumin significantly reduced the number of apoptotic cells and inhibited the upregulation of cyt-c, caspase-9, and caspase-3 at 7 days p.i.	Curcumin	0-8	caspase 3	Mus musculus	117-126
24157857-0	2013	Amelioration of beta-amyloid-induced cognitive dysfunction and hippocampal axon degeneration by curcumin is associated with suppression of CRMP-2 hyperphosphorylation.	Curcumin	96-104	dihydropyrimidinase-like 2	Rattus norvegicus	139-145
24157857-4	2013	One possibility is that curcumin prevents beta-amyloid-induced CRMP-2 hyperphosphorylation, thereby protecting against axonal regression and (or) promoting axonal regrowth.	Curcumin	24-32	dihydropyrimidinase-like 2	Rattus norvegicus	63-69
24157857-10	2013	Spatial learning deficits were reversed, CRMP-2 and NF-200 expression levels increased, and p-CRMP-2 expression reduced in curcumin-treated rats (all P&lt;0.05).	Curcumin	123-131	dihydropyrimidinase-like 2	Rattus norvegicus	94-100
24157857-11	2013	We propose that curcumin improves spatial learning by inhibiting CRMP-2 hyperphosphorylation, thus protecting against beta-amyloid-induced hippocampal damage or promoting regeneration.	Curcumin	16-24	dihydropyrimidinase-like 2	Rattus norvegicus	65-71
23839497-4	2013	Results in a human keratinocyte line, HaCaT, suggested that 1,25D, low affinity VDR ligands docosahexaenoic acid and curcumin, along with a novel candidate ligand, delphinidin, induce LCE transcripts as monitored by qPCR.	Curcumin	117-125	vitamin D receptor	Homo sapiens	80-83
23632743-8	2013	In addition, curcumin selectively suppressed AdBMP2-induced expression of HAT p300, but not HAT GCN5 in H9c2 cells.	Curcumin	13-21	E1A binding protein p300	Mus musculus	78-82
23632743-9	2013	The data indicated that inhibition of histone H3 acetylation with curcumin diminished BMP2-induced expression of GATA4 and MEF2C, suggesting that p300-mediated histone acetylation was essential for the regulation of GATA4 and MEF2C by BMP2 in H9c2 cells.	Curcumin	66-74	E1A binding protein p300	Mus musculus	146-150
24165291-8	2013	Curcumin suppressed cell proliferation, colony formation, migration, and induced apoptosis which was mediated partly through the mitochondrial pathway after an increase in the ratio of Bax to Bcl2.	Curcumin	0-8	BCL2-associated X protein	Mus musculus	185-188
24144778-6	2013	Ionizing radiation induced apoptosis through ROS generation and down-regulation of Prp4K, which was further potentiated by curcumin treatment.	Curcumin	123-131	pre-mRNA processing factor 4B	Homo sapiens	83-88
24144778-12	2013	Collectively, these results suggest a novel mechanism for curcumin-mediated radio-sensitization of cancer based on ROS generation and down-regulation of Prp4K.	Curcumin	58-66	pre-mRNA processing factor 4B	Homo sapiens	153-158
24184481-12	2013	However, MCP-1 and F4/80 mRNA expression levels were significantly attenuated by curcumin administration in downhill running mice.	Curcumin	81-89	adhesion G protein-coupled receptor E1	Mus musculus	19-24
24260158-0	2013	Targeting JNK by a new curcumin analog to inhibit NF-kB-mediated expression of cell adhesion molecules attenuates renal macrophage infiltration and injury in diabetic mice.	Curcumin	23-31	mitogen-activated protein kinase 8	Mus musculus	10-13
24065177-6	2013	Furthermore, flow cytometry showed that curcumin significantly inhibited the surface expression of CD44 in SKOV3 cells and DCs, while BPS had a minimal effect on CD44 expression.	Curcumin	40-48	CD44 molecule (Indian blood group)	Homo sapiens	99-103
24065177-7	2013	Matrix metallopeptidase-9 (MMP-9) mRNA and protein expression were also reduced in all curcumin-treated cells and BPS-treated SKOV3 cells.	Curcumin	87-95	matrix metallopeptidase 9	Homo sapiens	0-25
24065177-7	2013	Matrix metallopeptidase-9 (MMP-9) mRNA and protein expression were also reduced in all curcumin-treated cells and BPS-treated SKOV3 cells.	Curcumin	87-95	matrix metallopeptidase 9	Homo sapiens	27-32
24065177-8	2013	The results indicated that curcumin and BPS regulated invasion of SKOV3 cells and DCs by distinctly downregulating OPN, CD44 and MMP-9 expression.	Curcumin	27-35	CD44 molecule (Indian blood group)	Homo sapiens	120-124
24065177-8	2013	The results indicated that curcumin and BPS regulated invasion of SKOV3 cells and DCs by distinctly downregulating OPN, CD44 and MMP-9 expression.	Curcumin	27-35	matrix metallopeptidase 9	Homo sapiens	129-134
24124525-10	2013	Our analyses showed that treatment of three-week-old CLN6 (nclf) mice with either 5% DHA or 0.6% curcumin for 30 weeks resulted in a reduced number of amoeboid reactive microglia and partially improved retinal function.	Curcumin	97-105	ceroid-lipofuscinosis, neuronal 6	Mus musculus	53-57
24011306-6	2013	Curcumin potently inhibited LPS-induced expression of IL-6, TNF-alpha and COX-2 mRNA and prevented LPS-induced inhibition of SOCS-1 and -3 expression and the inhibition of the activation of p38 MAPKinase by modulation of its nuclear translocation.	Curcumin	0-8	suppressor of cytokine signaling 1	Mus musculus	125-138
24011306-7	2013	In conclusion, curcumin potently inhibits expression of LPS-induced inflammatory cytokines in macrophages via mechanisms that involve modulation of expression and activity of SOCS-1 and SOCS-3 and of p38 MAPK.	Curcumin	15-23	suppressor of cytokine signaling 1	Mus musculus	175-181
23174956-0	2013	Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway.	Curcumin	0-8	Kelch-like ECH-associated protein 1	Rattus norvegicus	106-111
23174956-8	2013	CONCLUSION: These findings demonstrate that, by modulating Nrf2-Keap1 pathway, the curcumin effectively attenuates oxidative stress, inflammation, and renal fibrosis, which suggest that curcumin hold promising potential for safe treatment of chronic kidney disease.	Curcumin	83-91	Kelch-like ECH-associated protein 1	Rattus norvegicus	64-69
23174956-8	2013	CONCLUSION: These findings demonstrate that, by modulating Nrf2-Keap1 pathway, the curcumin effectively attenuates oxidative stress, inflammation, and renal fibrosis, which suggest that curcumin hold promising potential for safe treatment of chronic kidney disease.	Curcumin	186-194	Kelch-like ECH-associated protein 1	Rattus norvegicus	64-69
23991371-9	2013	Moreover, GFAP-positive staining was decreased in curcumin group compared with diabetic group.	Curcumin	50-58	glial fibrillary acidic protein	Rattus norvegicus	10-14
23812632-1	2013	Curcumin, a potent anti-inflammatory and antioxidant agent, modulates peroxisome proliferator-activated receptor-gamma signaling, a key molecule in the etiology of bronchopulmonary dysplasia (BPD).	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	70-118
23645386-3	2013	Here, we evaluated the ability of some curcumin by-products: dehydrozingerone (1), its O-methyl derivative (2), zingerone (3), and their biphenyl analogues (4-6) to interact with alpha-synuclein (AS), using CD and fluorescence spectroscopy.	Curcumin	39-47	synuclein alpha	Rattus norvegicus	179-194
23977989-0	2013	Curcumin ameliorates TNF-alpha-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells.	Curcumin	0-8	intercellular adhesion molecule 1	Homo sapiens	39-45
23977989-2	2013	In this study, we investigated the inhibitory effects of curcumin on ICAM-1 expression and monocyte adhesiveness as well as its underlying action mechanism in the TNF-alpha-stimulated keratinocytes.	Curcumin	57-65	intercellular adhesion molecule 1	Homo sapiens	69-75
23977989-5	2013	Curcumin suppressed TNF-alpha- induced ICAM-1 expression and subsequent monocyte adhesion, which were reversed by the addition of tin protoporphyrin IX (SnPP), a specific inhibitor of HO-1, or HO-1 knockdown using siRNA.	Curcumin	0-8	intercellular adhesion molecule 1	Homo sapiens	39-45
23977989-6	2013	Furthermore, Nrf2 knockdown using siRNA reversed the inhibitory effect of curcumin on the TNF-alpha-induced ICAM-1 expression and adhesion of monocytes to keratinocytes.	Curcumin	74-82	intercellular adhesion molecule 1	Homo sapiens	108-114
23977989-7	2013	These results suggest that curcumin may exert its anti-inflammatory activity by suppressing the TNF-alpha-induced ICAM-1 expression and subsequent monocyte adhesion via expression of HO-1 in the keratinocytes.	Curcumin	27-35	intercellular adhesion molecule 1	Homo sapiens	114-120
23946685-6	2013	Moreover, western blot analysis revealed that curcumin lowered radiation-induced increases of tumor necrosis factor-alpha (TNF-alpha), TNF receptor 1 (TNFR1), and cyclooxygenase-2 (COX-2).	Curcumin	46-54	TNF receptor superfamily member 1A	Rattus norvegicus	135-149
23946685-6	2013	Moreover, western blot analysis revealed that curcumin lowered radiation-induced increases of tumor necrosis factor-alpha (TNF-alpha), TNF receptor 1 (TNFR1), and cyclooxygenase-2 (COX-2).	Curcumin	46-54	TNF receptor superfamily member 1A	Rattus norvegicus	151-156
23815987-0	2013	Curcumin analogue T83 exhibits potent antitumor activity and induces radiosensitivity through inactivation of Jab1 in nasopharyngeal carcinoma.	Curcumin	0-8	COP9 signalosome subunit 5	Homo sapiens	110-114
23815987-5	2013	In this study, we explored the antitumor effect of a curcumin analogue T83 in NPC, and found T83 exhibits antitumor activity and induces radiosensitivity through inactivation of Jab1 in NPC.	Curcumin	53-61	COP9 signalosome subunit 5	Homo sapiens	178-182
23825622-4	2013	Here, we report that topical use of a curcumin gel formulation strongly inhibited imiquimod (IMQ)-induced psoriasis-like inflammation, the development of which was based on the IL-23/IL-17A axis.	Curcumin	38-46	interleukin 17A	Mus musculus	183-189
23825622-6	2013	Real-time PCR showed that mRNA levels of IL-17A, IL-17F, IL-22, IL-1beta, IL-6 and TNF-alpha cytokines were decreased significantly by curcumin in ear skin, an effect similar to that of clobetasol.	Curcumin	135-143	interleukin 17A	Mus musculus	41-47
26770672-2	2013	Herein, we confirmed that curcumin induces human neutrophil apoptosis as assessed by cytology and by increase in the cell surface expression of annexin-V and CD16 shedding.	Curcumin	26-34	Fc gamma receptor IIIa	Homo sapiens	158-162
23739680-6	2013	Two main cell cycle related proteins cyclin D1 and cyclin B1 were significantly inhibited at the present of EGCG and curcumin.	Curcumin	117-125	cyclin D1	Mus musculus	37-46
23548270-10	2013	We found that curcumin administration increased miR-145 promoter activity, thereby decreasing SOX9/ADAM17 expression and eliminating TICs in HNC cell populations.	Curcumin	14-22	ADAM metallopeptidase domain 17	Homo sapiens	99-105
23548270-13	2013	Collectively, our results show how miR-145 targets the SOX9/ADAM17 axis to regulate TIC properties in HNC, and how altering this pathway may partly explain the anticancer effects of curcumin.	Curcumin	182-190	ADAM metallopeptidase domain 17	Homo sapiens	60-66
23730211-6	2013	Furthermore, curcumin suppressed the expression/secretion of stromal cell-derived factor-1 (SDF-1), interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2), MMP-9, and transforming growth factor-beta, which impeded their paracrine procarcinogenic potential.	Curcumin	13-21	matrix metallopeptidase 9	Homo sapiens	158-163
23563640-8	2013	The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P&lt;0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P&lt;0.01, respectively).	Curcumin	93-101	GLI family zinc finger 1	Homo sapiens	270-274
23563640-8	2013	The TGF-beta1-stimulated PANC-1 cells were treated with curcumin and the results showed that curcumin significantly inhibited TGF-beta1-stimulated PANC-1 cell proliferation and induced apoptosis, compared with other groups (P&lt;0.01), and the expression levels of Shh, GLI1 and vimentin in the curcumin-treated group were significantly decreased compared with those in the control group (P&lt;0.01, respectively).	Curcumin	93-101	GLI family zinc finger 1	Homo sapiens	270-274
23560895-7	2013	This study suggests that targeting LOX expression with food components such as PSB and curcumin may be a novel strategy to overcome ethanol-induced HCC cell metastasis in liver cancer patients.	Curcumin	87-95	lysyl oxidase	Homo sapiens	35-38
23466486-4	2013	Curcumin treatment significantly resulted in reduced matrix metalloproteinase 9 activity and downregulation of cellular matriptase, a membrane-anchored serine protease with oncogenic roles in tumor formation and invasion.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	53-79
23245727-8	2013	Renal TNF-alpha and MCP-1 concentrations and ICAM-1 mRNA expression in kidney in the cisplatin + curcumin group also significantly decreased compared with those in the cisplatin group.	Curcumin	97-105	chemokine (C-C motif) ligand 2	Mus musculus	20-25
22841393-3	2013	As potential ligands for the VDR, we hypothesized that curcumin and PUFAs would induce expression of known VDR target genes in cells.	Curcumin	55-63	vitamin D receptor	Homo sapiens	29-32
22841393-3	2013	As potential ligands for the VDR, we hypothesized that curcumin and PUFAs would induce expression of known VDR target genes in cells.	Curcumin	55-63	vitamin D receptor	Homo sapiens	107-110
22841393-6	2013	Curcumin treatment induced CAMP promoter activity from a luciferase reporter construct lacking the VDR binding site and did not increase binding of the VDR to the CAMP promoter as determined by chromatin immunoprecipitation assays.	Curcumin	0-8	vitamin D receptor	Homo sapiens	99-102
22841393-7	2013	These findings indicate that induction of CAMP by curcumin occurs through a vitamin D receptor-independent manner.	Curcumin	50-58	vitamin D receptor	Homo sapiens	76-94
23184090-9	2013	Treatment of B lymphocytes with curcumin suppressed IFNgamma-induced BAFF expression, STAT1 phosphorylation and nuclear translocation, suggesting that curcumin may repress IFNgamma-induced BAFF expression via negatively interfering with STAT1 signaling.	Curcumin	32-40	signal transducer and activator of transcription 1	Mus musculus	86-91
23184090-9	2013	Treatment of B lymphocytes with curcumin suppressed IFNgamma-induced BAFF expression, STAT1 phosphorylation and nuclear translocation, suggesting that curcumin may repress IFNgamma-induced BAFF expression via negatively interfering with STAT1 signaling.	Curcumin	32-40	signal transducer and activator of transcription 1	Mus musculus	237-242
23184090-9	2013	Treatment of B lymphocytes with curcumin suppressed IFNgamma-induced BAFF expression, STAT1 phosphorylation and nuclear translocation, suggesting that curcumin may repress IFNgamma-induced BAFF expression via negatively interfering with STAT1 signaling.	Curcumin	151-159	signal transducer and activator of transcription 1	Mus musculus	86-91
23184090-9	2013	Treatment of B lymphocytes with curcumin suppressed IFNgamma-induced BAFF expression, STAT1 phosphorylation and nuclear translocation, suggesting that curcumin may repress IFNgamma-induced BAFF expression via negatively interfering with STAT1 signaling.	Curcumin	151-159	signal transducer and activator of transcription 1	Mus musculus	237-242
22476324-4	2013	The increased activity of SOD and translated products of SOD1 and SOD2 in cerebral cortex of T4-treated rats was ameliorated on supplementation of curcumin.	Curcumin	147-155	superoxide dismutase 2	Rattus norvegicus	66-70
23415873-10	2013	These results suggest that curcumin can impact both ER stress and mitochondria functional pathways, and thereby could be used as a promising therapy in the context of Th1-mediated autoimmune diseases.	Curcumin	27-35	negative elongation factor complex member C/D	Homo sapiens	167-170
23662249-7	2013	In C2C12 fibroblasts, resveratrol and curcumin can efficiently inhibit myogenic expression and differentiation, for which LSD1 is required.	Curcumin	38-46	lysine demethylase 1A	Homo sapiens	122-126
23662249-8	2013	Thus, our study has identified LSD1 as a novel target of bioactive natural compounds, such as resveratrol, curcumin and quercetin, and such finding suggests that LSD1 inhibition can at least partially contribute to some of the previously observed beneficial effects of these compounds.	Curcumin	107-115	lysine demethylase 1A	Homo sapiens	31-35
23662249-8	2013	Thus, our study has identified LSD1 as a novel target of bioactive natural compounds, such as resveratrol, curcumin and quercetin, and such finding suggests that LSD1 inhibition can at least partially contribute to some of the previously observed beneficial effects of these compounds.	Curcumin	107-115	lysine demethylase 1A	Homo sapiens	162-166
22648527-8	2013	Oral curcumin (10 mg/kg, 4 days before the platinum drug, and thereafter, concomitantly with it for 4.5 weeks) reversed the alterations in the plasma neurotensin and sciatic nerve platinum concentrations, and markedly improved sciatic nerve histology in the platinum-treated rats.	Curcumin	5-13	neurotensin	Rattus norvegicus	150-161
23264626-10	2013	Instead curcumin differentially impacted HSP90 client kinases, reducing Fyn without reducing Akt.	Curcumin	8-16	Fyn proto-oncogene	Mus musculus	72-75
23276449-10	2013	These studies may lead to the discovery of novel curcumin analogs that activate nuclear receptors, including RXR, RAR and VDR, resulting in similar health benefits as those for vitamins A and D, such as lowering the risk of epithelial and colon cancers.	Curcumin	49-57	retinoid X receptor alpha	Homo sapiens	109-112
23276449-10	2013	These studies may lead to the discovery of novel curcumin analogs that activate nuclear receptors, including RXR, RAR and VDR, resulting in similar health benefits as those for vitamins A and D, such as lowering the risk of epithelial and colon cancers.	Curcumin	49-57	vitamin D receptor	Homo sapiens	122-125
23336507-0	2013	Curcumin as a potential treatment for Alzheimer"s disease: a study of the effects of curcumin on hippocampal expression of glial fibrillary acidic protein.	Curcumin	0-8	glial fibrillary acidic protein	Rattus norvegicus	123-154
23336507-0	2013	Curcumin as a potential treatment for Alzheimer"s disease: a study of the effects of curcumin on hippocampal expression of glial fibrillary acidic protein.	Curcumin	85-93	glial fibrillary acidic protein	Rattus norvegicus	123-154
23336507-6	2013	In this study, we intend to investigate the effects of curcumin in amyloid-beta (Abeta(1-40)) induced AD rat models on both the behavioral and molecular levels, that is to say, on their spatial memory and on the expression of GFAP in their hippocampi.	Curcumin	55-63	glial fibrillary acidic protein	Rattus norvegicus	226-230
23336507-7	2013	Our results were statistically significant, showing that the spatial memory of AD rats improved following curcumin treatment (p < 0.05), and that the expression of GFAP mRNA and the number of GFAP positive cells in the curcumin treated rats was decreased relative to the AD group rats (p < 0.05).	Curcumin	219-227	glial fibrillary acidic protein	Rattus norvegicus	164-168
23336507-7	2013	Our results were statistically significant, showing that the spatial memory of AD rats improved following curcumin treatment (p < 0.05), and that the expression of GFAP mRNA and the number of GFAP positive cells in the curcumin treated rats was decreased relative to the AD group rats (p < 0.05).	Curcumin	219-227	glial fibrillary acidic protein	Rattus norvegicus	192-196
23336507-9	2013	Taken together, these results suggest that curcumin improves the spatial memory disorders (such disorders being symptomatic of AD) in Abeta(1-40)-induced rats by down regulating GFAP expression and suppressing AS activity.	Curcumin	43-51	glial fibrillary acidic protein	Rattus norvegicus	178-182
23302632-7	2013	In this review, we describe a recent study on the cardiac transcriptional signal pathway, especially p300/GATA4 pathway, and a novel heart failure therapy using curcumin.	Curcumin	161-169	GATA binding protein 4	Homo sapiens	106-111
24858458-7	2013	In comparison to treatment with curcumin and etoposide alone, co-treatment with these compounds increased the extent of DNA damage, the percentage of cells arrested in the G2/M phase and the number of annexin-V-positive cells.	Curcumin	32-40	annexin A5	Rattus norvegicus	201-210
24048094-4	2013	Curcumin induced autophagy in the A549 human lung adenocarcinoma cell line, evidenced by LC3 immunofluorescence analysis and immunoblotting assays on LC3 and SQSTM1.	Curcumin	0-8	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	89-92
24048094-4	2013	Curcumin induced autophagy in the A549 human lung adenocarcinoma cell line, evidenced by LC3 immunofluorescence analysis and immunoblotting assays on LC3 and SQSTM1.	Curcumin	0-8	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	150-153
24048094-4	2013	Curcumin induced autophagy in the A549 human lung adenocarcinoma cell line, evidenced by LC3 immunofluorescence analysis and immunoblotting assays on LC3 and SQSTM1.	Curcumin	0-8	sequestosome 1	Homo sapiens	158-164
23124098-2	2013	Curcumin, extracted from Curcumae longae, has been shown to possess anti-inflammatory activity, in inflammation associated with the induction of MCP-1 expression.	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	145-150
23124098-3	2013	However, the underlying mechanisms involved in the effect of curcumin on MCP-1 expression remain unclear.	Curcumin	61-69	chemokine (C-C motif) ligand 2	Mus musculus	73-78
23124098-4	2013	In the current study, we investigated the effect of curcumin on the production of MCP-1 induced by lipopolysaccharide (LPS) in macrophages and the possible mechanisms involved.	Curcumin	52-60	chemokine (C-C motif) ligand 2	Mus musculus	82-87
23124098-5	2013	The results revealed that curcumin decreased MCP-1 production in a concentration-dependent manner and reduced the generation of reactive oxygen species (ROS) induced by LPS in RAW264.7 macrophages.	Curcumin	26-34	chemokine (C-C motif) ligand 2	Mus musculus	45-50
23124098-6	2013	Additionally, zinc protoporphyrin, a heme oxygenase-1 (HO-1) inhibitor, blocked the inhibitory effect of curcumin on the LPS-induced MCP-1 expression.	Curcumin	105-113	chemokine (C-C motif) ligand 2	Mus musculus	133-138
23124098-8	2013	Furthermore, additional experiments indicated that the inhibitory effect of curcumin on LPS-induced MCP-1 expression was significantly attenuated in the presence of N-acetylcysteine (an effective ROS scavenger).	Curcumin	76-84	chemokine (C-C motif) ligand 2	Mus musculus	100-105
22572473-5	2013	Here we provide evidence that curcumin ameliorates cognitive deficits associated with activation of the innate immune response by mechanisms requiring functional tumor necrosis factor alpha receptor 2 (TNFR2) signaling.	Curcumin	30-38	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	162-200
22572473-5	2013	Here we provide evidence that curcumin ameliorates cognitive deficits associated with activation of the innate immune response by mechanisms requiring functional tumor necrosis factor alpha receptor 2 (TNFR2) signaling.	Curcumin	30-38	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	202-207
22572473-7	2013	Curcumin treatment protected cultured neurons against glutamate-induced excitotoxicity by a mechanism requiring TNFR2 activation.	Curcumin	0-8	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	112-117
23113921-0	2012	Curcumin and diabetes: a role for the vitamin D receptor?	Curcumin	0-8	vitamin D receptor	Homo sapiens	38-56
23225435-8	2012	Both inhibitors of ABCC1/ABCC2 and depletion of intracellular glutathione levels were able to reverse hypoxia-induced curcumin resistance.	Curcumin	118-126	ATP binding cassette subfamily C member 2	Homo sapiens	25-30
23225435-9	2012	CONCLUSION: ABCC1 and ABCC2 play an important role in hypoxia-induced curcumin resistance in human hepatocellular carcinoma.	Curcumin	70-78	ATP binding cassette subfamily C member 2	Homo sapiens	22-27
23194063-1	2012	BACKGROUND: Curcumin inhibits growth of several cancer cell lines, and studies in this laboratory in bladder and pancreatic cancer cells show that curcumin downregulates specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and pro-oncogenic Sp-regulated genes.	Curcumin	12-20	Sp4 transcription factor	Homo sapiens	230-233
23194063-1	2012	BACKGROUND: Curcumin inhibits growth of several cancer cell lines, and studies in this laboratory in bladder and pancreatic cancer cells show that curcumin downregulates specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and pro-oncogenic Sp-regulated genes.	Curcumin	147-155	Sp4 transcription factor	Homo sapiens	230-233
23194063-6	2012	Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), survivin, bcl-2, cyclin D1 and NFkappaB (p65 and p50).	Curcumin	0-8	Sp4 transcription factor	Homo sapiens	197-200
23194063-7	2012	Curcumin and RL197 also induced reactive oxygen species (ROS), and cotreatment with the antioxidant glutathione significantly attenuated curcumin- and RL197-induced growth inhibition and downregulation of Sp1, Sp3, Sp4 and Sp-regulated genes.	Curcumin	0-8	Sp4 transcription factor	Homo sapiens	215-218
23194063-7	2012	Curcumin and RL197 also induced reactive oxygen species (ROS), and cotreatment with the antioxidant glutathione significantly attenuated curcumin- and RL197-induced growth inhibition and downregulation of Sp1, Sp3, Sp4 and Sp-regulated genes.	Curcumin	137-145	Sp4 transcription factor	Homo sapiens	215-218
23194063-8	2012	The mechanism of curcumin-/RL197-induced repression of Sp transcription factors was ROS-dependent and due to induction of the Sp repressors ZBTB10 and ZBTB4 and downregulation of microRNAs (miR)-27a, miR-20a and miR-17-5p that regulate these repressors.	Curcumin	17-25	zinc finger and BTB domain containing 4	Homo sapiens	151-156
22890222-5	2012	Further we show that curcumin inhibited p300 activity in the TREM-1 promoter region leading to hypoacetylation of histone 3 and 4 in the lysine residues.	Curcumin	21-29	E1A binding protein p300	Mus musculus	40-44
22221674-5	2012	Using the thioacetamide (TAA)-induced hepatic fibrosis animal model, we found that curcumin treatment up-regulated P53 protein expression and Bax messenger RNA (mRNA) expression and down-regulated Bcl-2 mRNA expression.	Curcumin	83-91	BCL2-associated X protein	Mus musculus	142-145
22904312-0	2012	Chemical chaperones curcumin and 4-phenylbutyric acid improve secretion of mutant factor H R127H by fibroblasts from a factor H-deficient patient.	Curcumin	20-28	complement factor H	Homo sapiens	82-90
22904312-8	2012	We then evaluated whether a treatment could increase the secretion of FH, and observed that the patient"s fibroblasts treated with the chemical chaperones 4-phenylbutiric acid or curcumin increased the secretion rate of FH.	Curcumin	179-187	complement factor H	Homo sapiens	70-72
22904312-8	2012	We then evaluated whether a treatment could increase the secretion of FH, and observed that the patient"s fibroblasts treated with the chemical chaperones 4-phenylbutiric acid or curcumin increased the secretion rate of FH.	Curcumin	179-187	complement factor H	Homo sapiens	220-222
22705585-5	2012	In particular, depending on the dose used, we have observed that curcumin is able to induce both HSP27 and alphaB-crystallin, to reduce expression of both RNA and protein of endogenous GFAP, to induce autophagy and, finally, to rescue the filamentous organization of the GFAP mutant protein, thus suggesting a role of this spice in counteracting the pathogenic effects of GFAP mutations.	Curcumin	65-73	glial fibrillary acidic protein	Homo sapiens	271-275
22705585-5	2012	In particular, depending on the dose used, we have observed that curcumin is able to induce both HSP27 and alphaB-crystallin, to reduce expression of both RNA and protein of endogenous GFAP, to induce autophagy and, finally, to rescue the filamentous organization of the GFAP mutant protein, thus suggesting a role of this spice in counteracting the pathogenic effects of GFAP mutations.	Curcumin	65-73	glial fibrillary acidic protein	Homo sapiens	271-275
24751005-2	2012	The developed curcumin loaded chitosan/poly(e-caprolactone) (chitosan/PCL) nanoparticle showed almost spherical shape and its diameter was varied between 220 nm and 360 nm and zeta potential was varied between +30 mV and 0 mV as a function with pH value.	Curcumin	14-22	PHD finger protein 1	Homo sapiens	70-73
24751005-6	2012	Furthermore, in vitro cell uptake study revealed that the cell uptake of curcumin was greatly enhanced by encapsulated curcumin into cationic chitosan/PCL nanoparticles.	Curcumin	73-81	PHD finger protein 1	Homo sapiens	151-154
24751005-6	2012	Furthermore, in vitro cell uptake study revealed that the cell uptake of curcumin was greatly enhanced by encapsulated curcumin into cationic chitosan/PCL nanoparticles.	Curcumin	119-127	PHD finger protein 1	Homo sapiens	151-154
24751005-7	2012	Therefore, the developed cationic chitosan/PCL nanoparticles might be a promising candidate for curcumin delivery to cancer cells.	Curcumin	96-104	PHD finger protein 1	Homo sapiens	43-46
22889562-1	2012	A series of new 4-arylidene curcumin analogues (4-arylidene-1,7-bisarylhepta-1,6-diene-3,5-diones) were synthesized and found to be potent antiproliferative agents against a panel of cancer cell lines at submicromolar to low micromolar concentrations by SRB assay.	Curcumin	28-36	chaperonin containing TCP1 subunit 4	Homo sapiens	254-257
22710872-10	2012	Dietary bael (Aegle marmelos) extract (4%) and curcumin (4%) restored signaling via the Notch and Wnt/beta-catenin pathways, thereby promoting crypt regeneration, and also replenished the mucus layer, leading to amelioration of C. rodentium- and DBZ-induced colitis in NIH:Swiss mice.	Curcumin	47-55	catenin (cadherin associated protein), beta 1	Mus musculus	102-114
22739211-3	2012	Curcumin dose-dependently inhibited basal VEGFA secretion in corticotroph AtT20 mouse and lactosomatotroph GH3 rat pituitary tumour cells as well as in all human pituitary adenoma cell cultures (n=32) studied.	Curcumin	0-8	vascular endothelial growth factor A	Mus musculus	42-47
22798207-5	2012	In the present study, we show that curcumin also has a similar effect on human neuroblastoma SHEP1 cells.	Curcumin	35-43	SH2 domain containing 3C	Homo sapiens	93-98
22668778-0	2012	LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin.	Curcumin	134-142	Leucine-rich repeat kinase	Drosophila melanogaster	0-5
22668778-9	2012	Moreover, curcumin significantly reduced LRRK2 kinase activity and the levels of oxidized proteins, and thus acted as not only an antioxidant but also a LRRK2 kinase inhibitor.	Curcumin	10-18	Leucine-rich repeat kinase	Drosophila melanogaster	41-46
22668778-9	2012	Moreover, curcumin significantly reduced LRRK2 kinase activity and the levels of oxidized proteins, and thus acted as not only an antioxidant but also a LRRK2 kinase inhibitor.	Curcumin	10-18	Leucine-rich repeat kinase	Drosophila melanogaster	153-158
22668778-11	2012	These studies also identified curcumin as a LRRK2 kinase inhibitor that may be a useful candidate for LRRK2-linked PD intervention.	Curcumin	30-38	Leucine-rich repeat kinase	Drosophila melanogaster	44-49
22668778-11	2012	These studies also identified curcumin as a LRRK2 kinase inhibitor that may be a useful candidate for LRRK2-linked PD intervention.	Curcumin	30-38	Leucine-rich repeat kinase	Drosophila melanogaster	102-107
22801507-5	2012	The aim of this study is to investigate whether the STAT3 inhibitor HO-3867, a novel curcumin analog, has a therapeutic effect on BRCA1-mutated ovarian cancer.	Curcumin	85-93	BRCA1 DNA repair associated	Homo sapiens	130-135
22548787-9	2012	Administration of pure curcumin or its water-soluble conjugate led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in eNOS, nNOS, HO-1, and Nrf2 genes, and a significant decrease in NF-Kbeta, p38, and iNOS genes.	Curcumin	23-31	heme oxygenase 1	Rattus norvegicus	141-153
22548787-9	2012	Administration of pure curcumin or its water-soluble conjugate led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in eNOS, nNOS, HO-1, and Nrf2 genes, and a significant decrease in NF-Kbeta, p38, and iNOS genes.	Curcumin	23-31	nitric oxide synthase 1	Rattus norvegicus	195-199
22548787-9	2012	Administration of pure curcumin or its water-soluble conjugate led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in eNOS, nNOS, HO-1, and Nrf2 genes, and a significant decrease in NF-Kbeta, p38, and iNOS genes.	Curcumin	23-31	heme oxygenase 1	Rattus norvegicus	141-145
22183741-0	2012	Curcumin attenuates TNF-alpha-induced expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and proinflammatory cytokines in human endometriotic stromal cells.	Curcumin	0-8	intercellular adhesion molecule 1	Homo sapiens	52-85
22183741-5	2012	Endometriotic stromal cells treated with curcumin showed marked suppression of TNF-alpha-induced mRNA expression of ICAM-1 and VCAM-1.	Curcumin	41-49	intercellular adhesion molecule 1	Homo sapiens	116-122
22183741-6	2012	Curcumin treatment also significantly decreased the TNF-alpha-induced cell surface and total protein expression of ICAM-1 and VCAM-1 in a dose-dependent manner.	Curcumin	0-8	intercellular adhesion molecule 1	Homo sapiens	115-121
22475723-8	2012	Further bioinformatic analysis shows that proteins modulated by curcumin are implicated in protein folding (such as heat-shock protein PPP2R1A; RNA splicing proteins RBM17, DDX39; cell death proteins HMGB1 and NPM1; proteins involved in androgen receptor signaling, NPM1 and FKBP4/FKBP52), and that this compound could have an impact on miR-141, miR-152, and miR-183 expression.	Curcumin	64-72	microRNA 152	Homo sapiens	346-353
22622204-4	2012	Exposed to H 2O 2, curcumin-treated HUVECs upregulate the level of microtubule-associated protein 1 light chain 3-II (LC3-II), the number of autophagosomes, and the degradation of p62.	Curcumin	19-27	nucleoporin 62	Homo sapiens	180-183
22441776-4	2012	Previously we demonstrated that curcumin, a natural plant polyphenol, increased the radiation sensitivity of HNSCC cells and that the observed sensitization was dependent on curcumin-mediated inhibition of thioredoxin reductase 1 (TxnRd1) a key cytosolic regulator of redox-dependent signaling.	Curcumin	32-40	thioredoxin reductase 1	Mus musculus	206-229
22441776-4	2012	Previously we demonstrated that curcumin, a natural plant polyphenol, increased the radiation sensitivity of HNSCC cells and that the observed sensitization was dependent on curcumin-mediated inhibition of thioredoxin reductase 1 (TxnRd1) a key cytosolic regulator of redox-dependent signaling.	Curcumin	32-40	thioredoxin reductase 1	Mus musculus	231-237
22441776-4	2012	Previously we demonstrated that curcumin, a natural plant polyphenol, increased the radiation sensitivity of HNSCC cells and that the observed sensitization was dependent on curcumin-mediated inhibition of thioredoxin reductase 1 (TxnRd1) a key cytosolic regulator of redox-dependent signaling.	Curcumin	174-182	thioredoxin reductase 1	Mus musculus	206-229
22441776-4	2012	Previously we demonstrated that curcumin, a natural plant polyphenol, increased the radiation sensitivity of HNSCC cells and that the observed sensitization was dependent on curcumin-mediated inhibition of thioredoxin reductase 1 (TxnRd1) a key cytosolic regulator of redox-dependent signaling.	Curcumin	174-182	thioredoxin reductase 1	Mus musculus	231-237
22441776-5	2012	Here, we examined curcumin-induced radiation sensitization in HNSCC cell lines with differing HPV status and expressing different levels of TxnRd1, in vitro.	Curcumin	18-26	thioredoxin reductase 1	Mus musculus	140-146
22443687-8	2012	Curcumin significantly increased the phosphorylation of ERK, JNK and their downstream molecules (c-Jun and Jun B).	Curcumin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	97-102
22994744-6	2012	At high concentrations of curcumin, TIMP-1, -2, -3 and -4 genes were up-regulated after 48 hours of treatment, their over-expression being accompanied by down-regulation of MMP-2 and MMP-9 gene expression levels in a concentration- and time-dependent manner.	Curcumin	26-34	matrix metallopeptidase 9	Homo sapiens	183-188
22994744-7	2012	These results suggest that curcumin plays a role in regulating cell metastasis by inhibiting MMP-2 and MMP-9 and up-regulating TIMP1 and TIMP4 gene expression in breast cancer cells.	Curcumin	27-35	matrix metallopeptidase 9	Homo sapiens	103-108
21567511-5	2012	The observation suggested that combined treatment of a low dosage of curcumin with inhibitors against epidermal growth factor receptor (EGFR), insulin-like growth factor 1 (IGF-1R), fibroblast growth factors receptor (FGFR), phosphatidylinositol 3-kinases (PI3K) or NF-kappaB signaling pathway may be a potential adjuvant therapy beneficial to NSCLC patients.	Curcumin	69-77	insulin like growth factor 1 receptor	Homo sapiens	173-179
23285282-10	2012	Curcumin treatment led to significant inhibition of F4/80 positive macrophages (P&lt;0.05) and GR-1 positive granulocytes infiltration (P&lt;0.05).	Curcumin	0-8	adhesion G protein-coupled receptor E1	Mus musculus	52-57
23285282-11	2012	VEGF mainly expressed in F4/80 positive macrophages in laser injury sites, which was suppressed by curcumin treatment (P&lt;0.01).	Curcumin	99-107	vascular endothelial growth factor A	Mus musculus	0-4
22523587-0	2012	Curcumin attenuates beta-catenin signaling in prostate cancer cells through activation of protein kinase D1.	Curcumin	0-8	catenin (cadherin associated protein), beta 1	Mus musculus	20-32
22523587-0	2012	Curcumin attenuates beta-catenin signaling in prostate cancer cells through activation of protein kinase D1.	Curcumin	0-8	protein kinase D1	Mus musculus	90-107
22523587-7	2012	Herein, we have demonstrated that curcumin activates PKD1, resulting in changes in beta-catenin signaling by inhibiting nuclear beta-catenin transcription activity and enhancing the levels of membrane beta-catenin in prostate cancer cells.	Curcumin	34-42	protein kinase D1	Mus musculus	53-57
22523587-7	2012	Herein, we have demonstrated that curcumin activates PKD1, resulting in changes in beta-catenin signaling by inhibiting nuclear beta-catenin transcription activity and enhancing the levels of membrane beta-catenin in prostate cancer cells.	Curcumin	34-42	catenin (cadherin associated protein), beta 1	Mus musculus	83-95
22523587-7	2012	Herein, we have demonstrated that curcumin activates PKD1, resulting in changes in beta-catenin signaling by inhibiting nuclear beta-catenin transcription activity and enhancing the levels of membrane beta-catenin in prostate cancer cells.	Curcumin	34-42	catenin (cadherin associated protein), beta 1	Mus musculus	128-140
22523587-7	2012	Herein, we have demonstrated that curcumin activates PKD1, resulting in changes in beta-catenin signaling by inhibiting nuclear beta-catenin transcription activity and enhancing the levels of membrane beta-catenin in prostate cancer cells.	Curcumin	34-42	catenin (cadherin associated protein), beta 1	Mus musculus	128-140
22523587-9	2012	In addition, we have also revealed that inhibition of cell motility by curcumin is mediated by decreasing the levels of active cofilin, a downstream target of PKD1.	Curcumin	71-79	protein kinase D1	Mus musculus	159-163
22523587-12	2012	Overall, our findings herein have revealed a novel molecular mechanism of curcumin action via the activation of PKD1 in prostate cancer cells.	Curcumin	74-82	protein kinase D1	Mus musculus	112-116
21938566-0	2011	Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells.	Curcumin	94-102	neurogenin 1	Homo sapiens	83-90
21732406-6	2011	Curcumin generated an aberrant RANKL signal characterized by reduced expression of nuclear factor of activated T cells 2 (NFAT2) and attenuated activation of mitogen-activated protein kinases (ERK, JNK, and p38).	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	198-201
22005253-9	2011	Piperine was able to decrease the content of myofibrils and slightly increase actin, while curcumin also prevented elastin decrease.	Curcumin	91-99	elastin	Rattus norvegicus	115-122
21810436-0	2011	Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells.	Curcumin	0-8	RAD51 recombinase	Homo sapiens	100-105
21325634-9	2011	Fourth, curcumin upregulated death receptors, DR4 and DR5.	Curcumin	8-16	major histocompatibility complex, class II, DR beta 4	Homo sapiens	46-49
21546578-7	2011	Inhibitors of NF-kappaB (curcumin, SN-50) attenuated TNF-alpha-induced enhancement of TRPC1 expression, store-dependent Ca(2+) influx, and COX-2-dependent PGE(2) production.	Curcumin	25-33	transient receptor potential cation channel subfamily C member 1	Homo sapiens	86-91
20672906-11	2011	PPARgamma was expressed in ELT-3 cells and curcumin acted as a PPARgamma ligand.	Curcumin	43-51	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	63-72
20672906-12	2011	This inhibitory effect of curcumin was attenuated by the treatment of cells with PPARgamma antagonist.	Curcumin	26-34	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	81-90
20672906-13	2011	CONCLUSION: These experimental findings in vitro show that the inhibitory effect of curcumin on ELT-3 cell proliferation occurs through the activation of PPARgamma.	Curcumin	84-92	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	154-163
21529317-4	2011	RANTES and inducible nitric oxide synthase expression as well as RANTES-positive astrocytes were all induced by injury accompanied by the elevation of lipid peroxidation, and attenuated by the curcumin treatment.	Curcumin	193-201	C-C motif chemokine ligand 5	Rattus norvegicus	0-6
21529317-4	2011	RANTES and inducible nitric oxide synthase expression as well as RANTES-positive astrocytes were all induced by injury accompanied by the elevation of lipid peroxidation, and attenuated by the curcumin treatment.	Curcumin	193-201	C-C motif chemokine ligand 5	Rattus norvegicus	65-71
21529317-5	2011	In primary cultured rat astrocytes challenged with lipopolysaccharide (LPS) to mimic astrocyte reactivation following SCI, LPS induces robust increase of RANTES expression and the effect was also reduced by 1 muM curcumin treatment.	Curcumin	213-221	C-C motif chemokine ligand 5	Rattus norvegicus	154-160
21529317-8	2011	Therefore, curcumin reduction of robust RANTES production in reactivated astrocytes both in vitro and in vivo may contribute to its neuroprotection and potential application in SCI.	Curcumin	11-19	C-C motif chemokine ligand 5	Rattus norvegicus	40-46
21538854-0	2011	Curcumin reduces pulmonary tumorigenesis in vascular endothelial growth factor (VEGF)-overexpressing transgenic mice.	Curcumin	0-8	vascular endothelial growth factor A	Mus musculus	44-78
21538854-0	2011	Curcumin reduces pulmonary tumorigenesis in vascular endothelial growth factor (VEGF)-overexpressing transgenic mice.	Curcumin	0-8	vascular endothelial growth factor A	Mus musculus	80-84
21538854-4	2011	In addition, we demonstrated a relationship between curcumin treatment and the expression of VEGF, EGFR, ERK2, and Cyclin A at the transcriptional and translational levels.	Curcumin	52-60	vascular endothelial growth factor A	Mus musculus	93-97
21317540-4	2011	When UGT1A-expressing HEK293 cells and LS180 cells were treated with curcumin or calphostin C, the exogenous and endogenous UGT1A protein levels in homogenates prepared with Tris-buffered saline were significantly decreased.	Curcumin	69-77	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	5-10
21317540-4	2011	When UGT1A-expressing HEK293 cells and LS180 cells were treated with curcumin or calphostin C, the exogenous and endogenous UGT1A protein levels in homogenates prepared with Tris-buffered saline were significantly decreased.	Curcumin	69-77	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	124-129
21811692-11	2011	Curcumin also attenuated DNA binding activity of p50 and p65 subunits and suppressed STAT1 phosphorylation.	Curcumin	0-8	signal transducer and activator of transcription 1	Mus musculus	85-90
21199667-0	2011	Curcumin enhances neuronal survival in N-methyl-d-aspartic acid toxicity by inducing RANTES expression in astrocytes via PI-3K and MAPK signaling pathways.	Curcumin	0-8	C-C motif chemokine ligand 5	Rattus norvegicus	85-91
21199667-5	2011	We sought to investigate whether curcumin exhibited neuroprotective and antioxidant activity via enhanced RANTES expression by astrocytes in cortical neuron cultures.	Curcumin	33-41	C-C motif chemokine ligand 5	Rattus norvegicus	106-112
21199667-9	2011	Real-time polymerase chain reaction was performed to assess RANTES and iNOS mRNA expression in astrocytes following curcumin treatment.	Curcumin	116-124	C-C motif chemokine ligand 5	Rattus norvegicus	60-66
21199667-10	2011	ELISA was used to detect astrocyte-secreted RANTES protein in ACM with curcumin treatment.	Curcumin	71-79	C-C motif chemokine ligand 5	Rattus norvegicus	44-50
21199667-15	2011	RESULTS: We demonstrated that curcumin enhanced RANTES expression in primary cultured astrocytes, and that this effect was related to activation of PI-3K and MAPK signaling pathways.	Curcumin	30-38	C-C motif chemokine ligand 5	Rattus norvegicus	48-54
21199667-17	2011	We also found that neurons exposed to NMDA and cultured with curcumin treated ACM, which characteristically exhibited elevated RANTES expression showed higher level of cell viability and lower level of cell death.	Curcumin	61-69	C-C motif chemokine ligand 5	Rattus norvegicus	127-133
21199667-19	2011	CONCLUSION: We postulate that the enhanced neuronal survival by curcumin treatment in NMDA toxicity and long-term cultures was in part attributable to elevated astrocyte-derived RANTES expression via activation of PI3K/MAPK signaling pathways.	Curcumin	64-72	C-C motif chemokine ligand 5	Rattus norvegicus	178-184
21756762-0	2011	[Effect of curcumin on the expression of high mobility group box 1 and apoptotic neurons in hippocampus after global cerebral ischemia reperfusion in rats].	Curcumin	11-19	high mobility group box 1	Rattus norvegicus	41-66
21756762-1	2011	OBJECTIVE: To explore the effects of curcumin on the expression of high mobility group box 1 (HMGB1) and apoptotic neurons in hippocampus after global cerebral ischemia/reperfusion in SD rats.	Curcumin	37-45	high mobility group box 1	Rattus norvegicus	67-92
21756762-1	2011	OBJECTIVE: To explore the effects of curcumin on the expression of high mobility group box 1 (HMGB1) and apoptotic neurons in hippocampus after global cerebral ischemia/reperfusion in SD rats.	Curcumin	37-45	high mobility group box 1	Rattus norvegicus	94-99
21334417-0	2011	Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats.	Curcumin	0-8	brain-derived neurotrophic factor	Rattus norvegicus	88-92
21334417-5	2011	Treatment of the rats with curcumin significantly suppressed the depression-like behavior and the decrease in brain BDNF levels induced by the repeated CORT injections.	Curcumin	27-35	brain-derived neurotrophic factor	Rattus norvegicus	116-120
21334417-6	2011	The results suggest that curcumin produces an antidepressant-like effect in CORT-treated rats, which is possibly mediated by increasing BDNF expression in the hippocampus and frontal cortex.	Curcumin	25-33	brain-derived neurotrophic factor	Rattus norvegicus	136-140
20018302-13	2011	RT-PCR demonstrated that the expression of glial fibrillary acidic protein (GFAP) was significantly inhibited by curcumin.	Curcumin	113-121	glial fibrillary acidic protein	Rattus norvegicus	43-74
20018302-13	2011	RT-PCR demonstrated that the expression of glial fibrillary acidic protein (GFAP) was significantly inhibited by curcumin.	Curcumin	113-121	glial fibrillary acidic protein	Rattus norvegicus	76-80
20018302-15	2011	By down-regulating GFAP expression, curcumin seems to attenuate astrocyte reactivation, which may be beneficial for neuronal survival.	Curcumin	36-44	glial fibrillary acidic protein	Rattus norvegicus	19-23
21161336-5	2011	RESULTS: We observed that CDF together with 5-FU + Ox were more potent than curcumin in reducing CD44 and CD166 in chemo-resistant colon cancer cells, accompanied by inhibition of growth, induction of apoptosis and disintegration of colonospheres.	Curcumin	76-84	CD44 molecule (Indian blood group)	Homo sapiens	97-101
21282056-0	2011	Enhancement of pancreatic lipase inhibitory activity of curcumin by radiolytic transformation.	Curcumin	56-64	pancreatic lipase	Homo sapiens	15-32
21282056-3	2011	The steroisomeric phenylpropanoids 4 and 5 exhibited significantly enhanced inhibitory activity against pancreatic lipase when compared to parent curcumin.	Curcumin	146-154	pancreatic lipase	Homo sapiens	104-121
21187084-11	2011	Furthermore, curcumin reduced the intracellular signaling proteins Ras, B-raf, p-MEK, p-ERK, c-fos, Egr-1, but increased Raf-1 and NAB2 in MDCK cells exposed to forskolin.	Curcumin	13-21	early growth response 1	Canis lupus familiaris	100-105
21195127-0	2011	Curcumin diminishes the impacts of hyperglycemia on the activation of hepatic stellate cells by suppressing membrane translocation and gene expression of glucose transporter-2.	Curcumin	0-8	solute carrier family 2 member 2	Homo sapiens	154-175
21195127-9	2011	Curcumin abrogated the membrane translocation of GLUT2 by interrupting the p38 MAPK signaling pathway.	Curcumin	0-8	solute carrier family 2 member 2	Homo sapiens	49-54
21195127-10	2011	In addition, curcumin suppressed glut2 expression by stimulating the activity of peroxisome proliferator-activated receptor-gamma (PPARgamma) and de novo synthesis of glutathione.	Curcumin	13-21	solute carrier family 2 member 2	Homo sapiens	33-38
21195127-11	2011	In conclusion, hyperglycemia stimulated HSC activation in vitro by increasing intracellular glucose, which was eliminated by curcumin by blocking the membrane translocation of GLUT2 and suppressing glut2 expression.	Curcumin	125-133	solute carrier family 2 member 2	Homo sapiens	176-181
21195127-11	2011	In conclusion, hyperglycemia stimulated HSC activation in vitro by increasing intracellular glucose, which was eliminated by curcumin by blocking the membrane translocation of GLUT2 and suppressing glut2 expression.	Curcumin	125-133	solute carrier family 2 member 2	Homo sapiens	198-203
20950131-9	2011	Protein concentration of IL-1beta, IL-6 (section 3), and CCL2 was increased (P &lt; 0.05) and curcumin reduced this response for IL-1beta (section 2) and CCL2 (P &lt; 0.05).	Curcumin	94-102	chemokine (C-C motif) ligand 2	Mus musculus	154-158
20950131-10	2011	Curcumin also offset the increase in plasma CCL2 (P &lt; 0.05).	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	44-48
21456169-10	2011	EPC liposomal curcumin in a molar ratio of curcumin/EPC 1:14 has shown improved cytotoxic activity versus free curcumin against colorectal cancer cell lines.	Curcumin	14-22	enhancer of polycomb homolog 1	Homo sapiens	52-57
21044622-9	2011	Moreover, pretreatment with SP600125 (JNK inhibitor) or curcumin (AP-1 inhibitor) markedly attenuated the berberine-induced PON1 promoter activity and protein expression.	Curcumin	56-64	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-70
22189739-12	2011	Immunohistochemistry showed reduced expression of cyclin D1 in the curcumin-treated group.	Curcumin	67-75	cyclin D1	Mus musculus	50-59
22189739-13	2011	All of the cells in mice treated with curcumin were p21 positive, suggesting that the p53 pathway is induced by this compound.	Curcumin	38-46	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	52-55
32272532-5	2011	Consistently, dose-dependent inhibition of ICRAC by curcumin was confirmed in Jurkat-T (IC50, 5.9 muM) and the HEK293 cells overexpressing Orai1 and STIM1 (IC50, 0.6 muM).	Curcumin	52-60	ORAI calcium release-activated calcium modulator 1	Homo sapiens	139-144
22141190-4	2011	Omega 3 fatty acids and curcumin elevate levels of molecules important for synaptic plasticity such as brain-derived neurotrophic factor (BDNF), thus benefiting normal brain function and recovery events following brain insults.	Curcumin	24-32	brain derived neurotrophic factor	Homo sapiens	103-136
22141190-4	2011	Omega 3 fatty acids and curcumin elevate levels of molecules important for synaptic plasticity such as brain-derived neurotrophic factor (BDNF), thus benefiting normal brain function and recovery events following brain insults.	Curcumin	24-32	brain derived neurotrophic factor	Homo sapiens	138-142
21857083-8	2011	In addition, curcumin significantly decreased p38MAPK and phospho-CDC-2 protein expression and increased phospho-p38MAPK, p42/44MAPK, and phospho-p42/44MAPK protein expression.	Curcumin	13-21	erythrocyte membrane protein band 4.2	Homo sapiens	122-125
21857083-8	2011	In addition, curcumin significantly decreased p38MAPK and phospho-CDC-2 protein expression and increased phospho-p38MAPK, p42/44MAPK, and phospho-p42/44MAPK protein expression.	Curcumin	13-21	erythrocyte membrane protein band 4.2	Homo sapiens	146-149
21034749-11	2010	SIGNIFICANCE: p300 interacts with cardiac-specific genes, GATA4, Nkx2.5 and Mef2c, and inhibition of p300-HAT by curcumin down-regulates their expression through the inhibition of histone H3 acetylation in the promoter regions.	Curcumin	113-121	E1A binding protein p300	Mus musculus	14-18
21034749-11	2010	SIGNIFICANCE: p300 interacts with cardiac-specific genes, GATA4, Nkx2.5 and Mef2c, and inhibition of p300-HAT by curcumin down-regulates their expression through the inhibition of histone H3 acetylation in the promoter regions.	Curcumin	113-121	E1A binding protein p300	Mus musculus	101-105
21328975-9	2010	The neuroprotection of curcumine in SHR is related to c-jun and c-fos.	Curcumin	23-32	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	64-69
20615395-11	2010	Treatment with AP-1 inhibitors (tanshinone IIA and curcumin) also reduced GDNF-induced glioma cell migration.	Curcumin	51-59	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	15-19
20605902-4	2010	Curcumin plus ATO or lonidamine stimulates typical events of the mitochondrial executioner pathway (Bax and Bid activation, cytochrome c release, X-linked inhibitor of apoptosis down-regulation, and caspase-9/-3 activation) and causes mitochondrial transmembrane potential dissipation, which nevertheless represents a late event in the apoptotic response.	Curcumin	0-8	X-linked inhibitor of apoptosis	Homo sapiens	146-177
20937593-5	2010	Reduced expression of cyclin D1, IkappaBalpha, phospho-IkappaBalpha, and IKKbeta occurred in cisplatin- and curcumin-treated cell lines.	Curcumin	108-116	cyclin D1	Mus musculus	22-31
21711478-1	2010	INTRODUCTION: Curcumin is an inducer of heme oxygenase enzyme-1 (HO-1) that is involved in erectile signaling via elevating cyclic guanosine monophosphate (cGMP)levels.	Curcumin	14-22	heme oxygenase 1	Rattus norvegicus	40-69
20435078-0	2010	Food preservatives sodium benzoate and propionic acid and colorant curcumin suppress Th1-type immune response in vitro.	Curcumin	67-75	negative elongation factor complex member C/D	Homo sapiens	85-88
20435078-1	2010	Food preservatives sodium benzoate and propionic acid and colorant curcumin are demonstrated to suppress in a dose-dependent manner Th1-type immune response in human peripheral blood mononuclear cells (PBMC) in vitro.	Curcumin	67-75	negative elongation factor complex member C/D	Homo sapiens	132-135
24900207-0	2010	KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue.	Curcumin	56-64	KH-type splicing regulatory protein	Homo sapiens	0-4
24900207-0	2010	KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue.	Curcumin	56-64	KH-type splicing regulatory protein	Homo sapiens	5-10
20357182-0	2010	Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/beta-catenin signaling.	Curcumin	0-8	catenin (cadherin associated protein), beta 1	Mus musculus	95-107
20357182-4	2010	Curcumin inhibited mitogen-activated protein kinase (MAPK) (ERK, JNK, and p38) phosphorylation that was associated with differentiation of 3T3-L1 cells into adipocytes.	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	65-68
20357182-5	2010	During differentiation, curcumin also restored nuclear translocation of the integral Wnt signaling component beta-catenin in a dose-dependent manner.	Curcumin	24-32	catenin (cadherin associated protein), beta 1	Mus musculus	109-121
20357182-6	2010	In parallel, curcumin reduced differentiation-stimulated expression of CK1alpha, GSK-3beta, and Axin, components of the destruction complex targeting beta-catenin.	Curcumin	13-21	catenin (cadherin associated protein), beta 1	Mus musculus	150-162
20357182-8	2010	Curcumin also increased mRNA levels of c-Myc and cyclin D1, well-known Wnt targets.	Curcumin	0-8	cyclin D1	Mus musculus	49-58
20405005-11	2010	Further, curcumin down-regulated the pro-survival protein Bcl-xL, depolarized the mitochondrial membrane, increased PARP cleavage, which led to apoptotic cell death.	Curcumin	9-17	poly (ADP-ribose) polymerase family, member 1	Mus musculus	116-120
20071421-9	2010	Interestingly, the lead-induced upregulation of GRP78 and GRP94 was almost completely blocked by the JNK inhibitor SP600125 or activator protein-1 (AP-1) inhibitor curcumin.	Curcumin	164-172	heat shock protein 90 beta family member 1	Bos taurus	58-63
20160040-0	2010	Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells.	Curcumin	33-41	thioredoxin reductase 1	Homo sapiens	0-23
20160040-3	2010	Here we report that an inhibitory activity of curcumin on the antioxidant enzyme thioredoxin reductase-1 (TxnRd1) is required for curcumin-mediated radiosensitization of squamous carcinoma cells.	Curcumin	46-54	thioredoxin reductase 1	Homo sapiens	81-104
20160040-3	2010	Here we report that an inhibitory activity of curcumin on the antioxidant enzyme thioredoxin reductase-1 (TxnRd1) is required for curcumin-mediated radiosensitization of squamous carcinoma cells.	Curcumin	46-54	thioredoxin reductase 1	Homo sapiens	106-112
20025076-5	2010	Moreover, curcumin inhibited the Shh-Gli1 signaling pathway by downregulating the Shh protein and its most important downstream targets GLI1 and PTCH1.	Curcumin	10-18	GLI family zinc finger 1	Homo sapiens	37-41
20025076-5	2010	Moreover, curcumin inhibited the Shh-Gli1 signaling pathway by downregulating the Shh protein and its most important downstream targets GLI1 and PTCH1.	Curcumin	10-18	GLI family zinc finger 1	Homo sapiens	136-140
20127004-0	2010	Curcumin blocks migration and invasion of mouse-rat hybrid retina ganglion cells (N18) through the inhibition of MMP-2, -9, FAK, Rho A and Rock-1 gene expression.	Curcumin	0-8	ras homolog family member A	Rattus norvegicus	129-134
20127004-0	2010	Curcumin blocks migration and invasion of mouse-rat hybrid retina ganglion cells (N18) through the inhibition of MMP-2, -9, FAK, Rho A and Rock-1 gene expression.	Curcumin	0-8	Rho-associated coiled-coil containing protein kinase 1	Rattus norvegicus	139-145
20060305-7	2010	By taking advantage of the SAR diagram, we have elaborated several advanced derivatives having GI(50) of single-digit micromolar potencies that will function as molecular probes to target and/or report key biomolecules interacting with curcumin and C(5)-curcumin.	Curcumin	236-244	sarcosine dehydrogenase	Homo sapiens	27-30
19886674-5	2010	Curcumin, a natural constituent of Curcuma longa (turmeric spice), is a nontoxic low-affinity SERCA (sarco (endo)plasmic reticulum calcium ATPase) pump inhibitor thought to permit DeltaF508 CFTR escape from the ER.	Curcumin	0-8	cystic fibrosis transmembrane conductance regulator	Mus musculus	190-194
20043100-10	2010	GSH and NAC, an anti-oxidant agent, blocked the curcumin-induced ROS production, MMP loss and rescued cells from curcumin-induced apoptosis.	Curcumin	48-56	X-linked Kx blood group	Homo sapiens	8-11
19836480-6	2010	RESULTS: Recent work has shown that curcumin protects human chondrocytes from the catabolic actions of interleukin-1 beta (IL-1beta) including matrix metalloproteinase (MMP)-3 up-regulation, inhibition of collagen type II and down-regulation of beta1-integrin expression.	Curcumin	36-44	integrin subunit beta 1	Homo sapiens	245-259
20492195-7	2010	Curcumin nanoemulsions show 85% inhibition of TPA-induced mouse ear inflammation as well as the inhibition of cyclin D1 expression, while dibenzoylmethane (DBM) nanoemulsion shows about 3-fold increase in oral bioavailability compared to the conventional DBM emulsion.	Curcumin	0-8	cyclin D1	Mus musculus	110-119
20661831-5	2010	Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak).	Curcumin	15-23	BCL2 antagonist/killer 1	Homo sapiens	282-285
20030852-0	2009	Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells.	Curcumin	79-87	ATP binding cassette subfamily A member 1	Homo sapiens	48-53
20030852-5	2009	We show that CXCL1 a chemokine that is down regulated in breast cancer cells by Curcumin in an NFkappaB dependent manner is expressed at variable levels in human melanomas.	Curcumin	80-88	C-X-C motif chemokine ligand 1	Homo sapiens	13-18
20030852-9	2009	Gene silencing of ABCA1 by siRNA sensitizes M14 cells to the apoptotic effect of Curcumin most likely as a result of reduced basal levels of active NFkappaB.	Curcumin	81-89	ATP binding cassette subfamily A member 1	Homo sapiens	18-23
19772879-8	2009	The overexpression of the above biomarkers was suppressed in tumors derived from VIP-treated PC3 cells that had been previously incubated with curcumin or NS-398.	Curcumin	143-151	proprotein convertase subtilisin/kexin type 1	Mus musculus	93-96
19956394-6	2009	Treatment of FOLFOX-surviving colon cancer cells with either curcumin alone or together with FOLFOX resulted in a marked reduction in CSCs, as evidenced by the decreased expression of CD44 and CD166 as well as EGFR and by their ability to form anchorage-dependent colonies.	Curcumin	61-69	CD44 molecule (Indian blood group)	Homo sapiens	184-188
21351482-0	2009	[Effect of curcumin on JAK-STAT signaling pathway in hepatoma cell lines].	Curcumin	11-19	signal transducer and activator of transcription 1	Homo sapiens	27-31
21351482-1	2009	The effect of curcumin on JAK-STAT signaling pathway was investigated in hepatoma cell lines Huh7 and Hep3B.	Curcumin	14-22	signal transducer and activator of transcription 1	Homo sapiens	30-34
21351482-1	2009	The effect of curcumin on JAK-STAT signaling pathway was investigated in hepatoma cell lines Huh7 and Hep3B.	Curcumin	14-22	MIR7-3 host gene	Homo sapiens	93-97
21351482-2	2009	Curcumin inhibited cell proliferation and induced apoptosis of both cell lines, but Huh7 cells were more sensitive to curcumin than Hep3B cells.	Curcumin	118-126	MIR7-3 host gene	Homo sapiens	84-88
21351482-3	2009	Curcumin (50 micromol x L(-1)) significantly increased phosphorylations of p38 (T180/Y182) and STAT-1 (S727) in Huh7 and Hep3B cells, and caused relocalization of phosphorylated-STAT-1 (Y701) from cytoplasm to nucleus in Hep3B cells.	Curcumin	0-8	signal transducer and activator of transcription 1	Homo sapiens	95-101
21351482-3	2009	Curcumin (50 micromol x L(-1)) significantly increased phosphorylations of p38 (T180/Y182) and STAT-1 (S727) in Huh7 and Hep3B cells, and caused relocalization of phosphorylated-STAT-1 (Y701) from cytoplasm to nucleus in Hep3B cells.	Curcumin	0-8	MIR7-3 host gene	Homo sapiens	112-116
21351482-3	2009	Curcumin (50 micromol x L(-1)) significantly increased phosphorylations of p38 (T180/Y182) and STAT-1 (S727) in Huh7 and Hep3B cells, and caused relocalization of phosphorylated-STAT-1 (Y701) from cytoplasm to nucleus in Hep3B cells.	Curcumin	0-8	signal transducer and activator of transcription 1	Homo sapiens	178-184
21351482-4	2009	In addition, curcumin (25 and 50 micromol x L(-1)) dramatically suppressed the phosphorylation level of STAT-1 (Y701) and resulted in a significant reduction of nuclear phosphorylated-STAT-1 (Y701) in Huh7 cells.	Curcumin	13-21	signal transducer and activator of transcription 1	Homo sapiens	104-110
21351482-4	2009	In addition, curcumin (25 and 50 micromol x L(-1)) dramatically suppressed the phosphorylation level of STAT-1 (Y701) and resulted in a significant reduction of nuclear phosphorylated-STAT-1 (Y701) in Huh7 cells.	Curcumin	13-21	signal transducer and activator of transcription 1	Homo sapiens	184-190
21351482-4	2009	In addition, curcumin (25 and 50 micromol x L(-1)) dramatically suppressed the phosphorylation level of STAT-1 (Y701) and resulted in a significant reduction of nuclear phosphorylated-STAT-1 (Y701) in Huh7 cells.	Curcumin	13-21	MIR7-3 host gene	Homo sapiens	201-205
19850041-2	2009	In this study we show that curcumin inhibits ALR2 with an IC(50) of 10 microM in a non-competitive manner, but is a poor inhibitor of closely-related members of the aldo-keto reductase superfamily, particularly aldehyde reductase.	Curcumin	27-35	aldo-keto reductase family 1 member A1	Homo sapiens	211-229
19839007-7	2009	These curcumin-treated DC induced differentiation of naive CD4(+) T cells into Treg resembling Treg in the intestine, including both CD4(+)CD25(+) Foxp3(+) Treg and IL-10-producing Tr1 cells.	Curcumin	6-14	CD4 antigen	Mus musculus	59-62
19839007-7	2009	These curcumin-treated DC induced differentiation of naive CD4(+) T cells into Treg resembling Treg in the intestine, including both CD4(+)CD25(+) Foxp3(+) Treg and IL-10-producing Tr1 cells.	Curcumin	6-14	CD4 antigen	Mus musculus	133-136
19623659-0	2009	Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	95-100
19623659-0	2009	Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.	Curcumin	0-8	C-X-C motif chemokine receptor 4	Homo sapiens	111-116
19393114-8	2009	Furthermore, curcumin inhibited proteasome complex activity and variably reduced expression of muscle-specific ubiquitin ligases: atrogin-1/muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MURF-1).	Curcumin	13-21	tripartite motif-containing 59	Mus musculus	180-193
19393114-8	2009	Furthermore, curcumin inhibited proteasome complex activity and variably reduced expression of muscle-specific ubiquitin ligases: atrogin-1/muscle atrophy F-box (MAFbx) and muscle RING finger 1 (MURF-1).	Curcumin	13-21	tripartite motif-containing 63	Mus musculus	195-201
19860939-9	2009	Using immunohistochemistry, we demonstrated a decrease in the expression of Cox-2 by 8% and Cyclin D1 by 13% in the animals treated with curcumin; both genes regulated by NF-kappaB and related to cell proliferation.	Curcumin	137-145	cyclin D1	Mus musculus	92-101
19246153-3	2009	We observe that curcumin activates hsp70A and hsp70B mRNA transcription, increases HSP protein expression but decreases the expression of Bag-1, a Hsp70 co-chaperone in K562 cells.	Curcumin	16-24	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	83-86
19513510-0	2009	Curcumin induces apoptosis through FAS and FADD, in caspase-3-dependent and -independent pathways in the N18 mouse-rat hybrid retina ganglion cells.	Curcumin	0-8	caspase 3	Mus musculus	52-61
19513510-8	2009	Curcumin also caused a marked increase in apoptosis, as characterized by DNA fragmentation (sub-G1 phase formation) and DAPI staining, and dysfunction of mitochondria, which was associated with the activation of caspase-8, -9 and -3.	Curcumin	0-8	caspase 8	Rattus norvegicus	212-232
19513510-9	2009	Curcumin also promoted the levels of Fas and FADD, Bax, cytochrome c release, but decreased the levels of Bcl-2 causing changes of DeltaPsim.	Curcumin	0-8	Fas associated via death domain	Rattus norvegicus	45-49
19513510-10	2009	Curcumin also induced endoplasmic reticulum stress in N18 cells which was based on the changes of GADD153 and GRP78 and caused Ca2+ release.	Curcumin	0-8	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	110-115
19359593-2	2009	Curcumin"s chemopreventive activity was tested in a transgenic mouse model of lung cancer that expresses the human Ki-ras(G12C) allele in a doxycycline (DOX) inducible and lung-specific manner.	Curcumin	0-8	KRAS proto-oncogene, GTPase	Homo sapiens	115-121
19191010-5	2009	Curcumin mediated apoptosis in these cells appears to be due to upregulation of proapoptotic Bax, AIF, release of cytochrome c and down regulation of antiapoptotic Bcl-2, Bcl-XL in HeLa and SiHa.	Curcumin	0-8	apoptosis inducing factor mitochondria associated 1	Homo sapiens	98-101
19368804-6	2009	Further examination of the B16F10 cells showed that curcumin effectively suppresses Cyclin D1, P-NF-kB, BclXL, P-Akt, and VEGF, which explains its efficacy in blocking proliferation, survival, and invasion of the B16F10 cells in the brain.	Curcumin	52-60	cyclin D1	Mus musculus	84-93
19368804-6	2009	Further examination of the B16F10 cells showed that curcumin effectively suppresses Cyclin D1, P-NF-kB, BclXL, P-Akt, and VEGF, which explains its efficacy in blocking proliferation, survival, and invasion of the B16F10 cells in the brain.	Curcumin	52-60	vascular endothelial growth factor A	Mus musculus	122-126
19280714-5	2009	Induction of cPLA2 by CSE was attenuated by selective inhibitors of NF-kappaB (helenalin) and AP-1 (curcumin).	Curcumin	100-108	phospholipase A2 group IVA	Homo sapiens	13-18
19176385-5	2009	We observed that curcumin inhibited mTORC1 signaling not by inhibition of the upstream kinases, such as insulin-like growth factor 1 receptor (IGF-IR) and phosphoinositide-dependent kinase 1 (PDK1).	Curcumin	17-25	pyruvate dehydrogenase kinase 1	Homo sapiens	192-196
19397204-0	2009	[Effects of curcumin on malondialdehyde and c-fos protein in hypoxia ischemia brain tissue in rats].	Curcumin	12-20	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	44-49
19397204-1	2009	OBJECTIVE: To explore the effects of curcumin on the content of malondialdehyde (MDA) and the expression level of c-fos protein following hypoxia ischemia brain damage (HIBD) in rats.	Curcumin	37-45	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	114-119
19397204-7	2009	The expression level of c-fos protein was higher in the curcumin group than that in the other groups (P&lt;0.05).	Curcumin	56-64	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	24-29
19397204-9	2009	CONCLUSION: Curcumin could significantly decrease the content of MDA, increase the expression level of c-fos protein and reduce the damage of the neuron cells.	Curcumin	12-20	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	103-108
18495463-8	2009	Importantly, BDMC and DMC at 10 microM reduced MT1-MMP and TIMP-2 protein expression, but curcumin slightly reduced only MT1-MMP but not TIMP-2.	Curcumin	90-98	TIMP metallopeptidase inhibitor 2	Homo sapiens	137-143
19033880-0	2009	Curcumin blocks chronic morphine analgesic tolerance and brain-derived neurotrophic factor upregulation.	Curcumin	0-8	brain derived neurotrophic factor	Homo sapiens	57-90
19033880-4	2009	Daily administration of the CREB-binding protein inhibitor curcumin abolished the upregulation of BDNF transcription and morphine analgesic tolerance.	Curcumin	59-67	brain derived neurotrophic factor	Homo sapiens	98-102
18222428-10	2009	The rats treated with curcumin had significant decreases in xanthine oxidase activity and malondialdehyde level and had significant increases in heme oxygenase-1 protein expression level and testicular spermatogenesis in ipsilateral testes, compared with the torsion-detorsion group.	Curcumin	22-30	heme oxygenase 1	Rattus norvegicus	145-161
18661553-6	2009	Moreover, we demonstrated that AP-1 (i.e., c-Fos/c-Jun) is crucial for oxLDL-induced proMMP-9 expression which was attenuated by pretreatment with AP-1 inhibitor (curcumin).	Curcumin	163-171	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	43-48
19127081-0	2009	Selective killing of leukemia and lymphoma cells ectopically expressing hCGbeta by a conjugate of curcumin with an antibody against hCGbeta subunit.	Curcumin	98-106	chorionic gonadotropin subunit beta 3	Homo sapiens	72-79
19127081-0	2009	Selective killing of leukemia and lymphoma cells ectopically expressing hCGbeta by a conjugate of curcumin with an antibody against hCGbeta subunit.	Curcumin	98-106	chorionic gonadotropin subunit beta 3	Homo sapiens	132-139
19127081-4	2009	This study was designed to determine whether this antibody alone or conjugated to curcumin can selectively kill tumor cells expressing hCGbeta.	Curcumin	82-90	chorionic gonadotropin subunit beta 3	Homo sapiens	135-142
19127081-11	2009	CONCLUSION: A humanized antibody against hCGbeta linked to curcumin has potential for therapy of hCGbeta-expressing tumors.	Curcumin	59-67	chorionic gonadotropin subunit beta 3	Homo sapiens	41-48
19127081-11	2009	CONCLUSION: A humanized antibody against hCGbeta linked to curcumin has potential for therapy of hCGbeta-expressing tumors.	Curcumin	59-67	chorionic gonadotropin subunit beta 3	Homo sapiens	97-104
19319191-10	2009	The activities of thioredoxin (Trx1) and thioredoxin reductase (TrxR1) were significantly elevated, whereas treatment with either curcumin, an irreversible inhibitor of TrxR1, or adiponectin largely attenuated their activities and resulted in the re-activation of PTEN in these tumor cells.	Curcumin	130-138	thioredoxin 1	Mus musculus	18-29
19319191-10	2009	The activities of thioredoxin (Trx1) and thioredoxin reductase (TrxR1) were significantly elevated, whereas treatment with either curcumin, an irreversible inhibitor of TrxR1, or adiponectin largely attenuated their activities and resulted in the re-activation of PTEN in these tumor cells.	Curcumin	130-138	thioredoxin 1	Mus musculus	31-35
19319191-10	2009	The activities of thioredoxin (Trx1) and thioredoxin reductase (TrxR1) were significantly elevated, whereas treatment with either curcumin, an irreversible inhibitor of TrxR1, or adiponectin largely attenuated their activities and resulted in the re-activation of PTEN in these tumor cells.	Curcumin	130-138	thioredoxin 1	Mus musculus	41-52
19319191-10	2009	The activities of thioredoxin (Trx1) and thioredoxin reductase (TrxR1) were significantly elevated, whereas treatment with either curcumin, an irreversible inhibitor of TrxR1, or adiponectin largely attenuated their activities and resulted in the re-activation of PTEN in these tumor cells.	Curcumin	130-138	thioredoxin reductase 1	Mus musculus	64-69
19319191-10	2009	The activities of thioredoxin (Trx1) and thioredoxin reductase (TrxR1) were significantly elevated, whereas treatment with either curcumin, an irreversible inhibitor of TrxR1, or adiponectin largely attenuated their activities and resulted in the re-activation of PTEN in these tumor cells.	Curcumin	130-138	thioredoxin reductase 1	Mus musculus	169-174
19096161-1	2008	The rat amyloid-beta (Abeta) intracerebroventricular infusion can model aspects of Alzheimer"s disease (AD) and has predicted efficacy of therapies such as ibuprofen and curcumin in transgenic mouse models.	Curcumin	170-178	amyloid beta precursor protein	Rattus norvegicus	22-27
18629638-11	2008	Recent findings suggest that several phytochemicals exhibit biphasic dose responses on cells with low doses activating signaling pathways that result in increased expression of vitagenes encoding survival proteins, as in the case of the Keap1/Nrf2/ARE pathway activated by curcumin and NAD/NADH-sirtuin-1 activated by resveratrol.	Curcumin	273-281	sirtuin 1	Homo sapiens	295-304
18809455-9	2008	Moreover, curcumin induced Sa-reduced liver transaminases and phosphatases, plasma and brain AChE, and the levels of TP and Alb.	Curcumin	10-18	albumin	Rattus norvegicus	124-127
18583546-10	2008	AP-1-binding inhibitor curcumin also partially reversed the mitogenic effect of PGE(2).	Curcumin	23-31	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
18794131-0	2008	Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1.	Curcumin	0-8	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	88-92
18794131-2	2008	In this study, we found that curcumin can inhibit cancer cell invasion and metastasis through activation of the tumor suppressor DnaJ-like heat shock protein 40 (HLJ1).	Curcumin	29-37	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	129-160
18794131-2	2008	In this study, we found that curcumin can inhibit cancer cell invasion and metastasis through activation of the tumor suppressor DnaJ-like heat shock protein 40 (HLJ1).	Curcumin	29-37	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	162-166
18794131-3	2008	Human lung adenocarcinoma cells (CL1-5) treated with curcumin (1-20 mumol/L) showed a concentration-dependent reduction in cell migration, invasion, and metastatic ability, and this was associated with increased HLJ1 expression.	Curcumin	53-61	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	212-216
18794131-4	2008	Knockdown of HLJ1 expression by siRNA was able to reverse the curcumin-induced anti-invasive and antimetastasis effects in vitro and in vivo.	Curcumin	62-70	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	13-17
18794131-5	2008	The HLJ1 promoter and enhancer in a luciferase reporter assay revealed that curcumin transcriptionally up-regulates HLJ1 expression through an activator protein (AP-1) site within the HLJ1 enhancer.	Curcumin	76-84	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	4-8
18794131-5	2008	The HLJ1 promoter and enhancer in a luciferase reporter assay revealed that curcumin transcriptionally up-regulates HLJ1 expression through an activator protein (AP-1) site within the HLJ1 enhancer.	Curcumin	76-84	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	116-120
18794131-5	2008	The HLJ1 promoter and enhancer in a luciferase reporter assay revealed that curcumin transcriptionally up-regulates HLJ1 expression through an activator protein (AP-1) site within the HLJ1 enhancer.	Curcumin	76-84	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	116-120
18794131-7	2008	Knockdown of JunD expression could partially reduce the curcumin-induced HLJ1 activation and diminish the anti-invasive effect of curcumin, indicating that JunD would seem to be involved in curcumin-induced HLJ1 expression.	Curcumin	56-64	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	73-77
18794131-7	2008	Knockdown of JunD expression could partially reduce the curcumin-induced HLJ1 activation and diminish the anti-invasive effect of curcumin, indicating that JunD would seem to be involved in curcumin-induced HLJ1 expression.	Curcumin	56-64	DnaJ heat shock protein family (Hsp40) member B4	Homo sapiens	207-211
18593936-4	2008	The results show that curcumin induced proteasome-dependent down-regulation of Sp1, Sp3, and Sp4 in 253JB-V and KU7 cells.	Curcumin	22-30	Sp4 transcription factor	Homo sapiens	93-96
18593936-5	2008	Moreover, using RNA interference with small inhibitory RNAs for Sp1, Sp3, and Sp4, we observed that curcumin-dependent inhibition of nuclear factor kappaB (NF-kappaB)-dependent genes, such as bcl-2, survivin, and cyclin D1, was also due, in part, to loss of Sp proteins.	Curcumin	100-108	Sp4 transcription factor	Homo sapiens	78-81
18593936-6	2008	Curcumin also decreased bladder tumor growth in athymic nude mice bearing KU7 cells as xenografts and this was accompanied by decreased Sp1, Sp3, and Sp4 protein levels in tumors.	Curcumin	0-8	Sp4 transcription factor	Homo sapiens	150-153
18523274-5	2008	Regardless of their constitutive or inducible expression, decreased H3K9Ac levels after treatment with a histone acetyltransferase inhibitor (Curcumin) led to decreased expression of all three genes in activated memory CD8 T cells.	Curcumin	142-150	CD8a molecule	Homo sapiens	219-222
18221818-8	2008	After 120 min exposure to 25 microM curcumin, hepatic glucose-6-phosphatase (G6Pase) activity and phosphoenolpyruvate carboxykinase (PEPCK) activity both were inhibited by 30%, but fructose-1,6-bisphosphatase (FBPase) was not reduced.	Curcumin	36-44	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	98-131
18221818-8	2008	After 120 min exposure to 25 microM curcumin, hepatic glucose-6-phosphatase (G6Pase) activity and phosphoenolpyruvate carboxykinase (PEPCK) activity both were inhibited by 30%, but fructose-1,6-bisphosphatase (FBPase) was not reduced.	Curcumin	36-44	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	133-138
18221818-10	2008	Thus, the anti-diabetic effects of curcumin are partly due to a reduction in hepatic glucose production caused by activation of AMP kinase and inhibition of G6Pase activity and PEPCK activity.	Curcumin	35-43	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	177-182
18646516-9	2008	When AP-1 activities were inhibited by curcumin, overexpression of p53 induced by B(a)P was not markedly changed.	Curcumin	39-47	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	5-9
18006204-0	2008	Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	104-120
18006204-5	2008	In the present study, we found that oral administration of curcumin at 200mg/kg dose for four consecutive days not only protected against dimethylnitrosamine (DMN)-induced hepatic injury, but also resulted in more than three-fold induction of HO-1 protein expression as well as activity in rat liver.	Curcumin	59-67	heme oxygenase 1	Rattus norvegicus	243-247
18006204-6	2008	Inhibition of HO-1 activity by zinc protoporphyrin-IX abrogated the hepatoprotective effect of curcumin against DMN toxicity.	Curcumin	95-103	heme oxygenase 1	Rattus norvegicus	14-18
18006204-9	2008	Taken together, these findings suggest that curcumin protects against DMN-induced hepatotoxicity, at least in part, through ARE-driven induction of HO-1 expression.	Curcumin	44-52	heme oxygenase 1	Rattus norvegicus	148-152
18316600-6	2008	Egr-1 expression is induced by curcumin through extracellular signal-regulated kinase (ERK) and c-Jun NH(2)-terminal kinase (JNK), but not the p38, mitogen-activated protein kinase (MAPK) pathways, which mediate the transactivation of Elk-1.	Curcumin	31-39	ETS transcription factor ELK1	Homo sapiens	235-240
18316600-9	2008	Our results indicate that ERK and JNK MAPK/Elk-1/Egr-1 signal cascade is required for p53-independent transcriptional activation of p21(Waf1/Cip1) in response to curcumin in U-87MG human glioblastoma cells.	Curcumin	162-170	ETS transcription factor ELK1	Homo sapiens	43-48
17879958-4	2008	We show that curcumin, an important inhibitor of CSN-associated kinases, can downregulate not only CSN5 but also MDM2, which results in p53 stabilization.	Curcumin	13-21	COP9 signalosome subunit 5	Homo sapiens	99-103
17879958-4	2008	We show that curcumin, an important inhibitor of CSN-associated kinases, can downregulate not only CSN5 but also MDM2, which results in p53 stabilization.	Curcumin	13-21	MDM2 proto-oncogene	Homo sapiens	113-117
18001810-10	2008	In line with this, curcumin also enhanced the mRNA expression of the oxidative stress response gene heme oxygenase-1 (ho-1).	Curcumin	19-27	heme oxygenase 1	Rattus norvegicus	100-116
18006644-7	2008	Furthermore, curcumin inhibits HSC activation by elevating the level of PPARgamma and reducing the abundance of platelet-derived growth factor, transforming growth factor-beta, their receptors, and type I collagen.	Curcumin	13-21	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	72-81
18226269-0	2008	Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis.	Curcumin	0-8	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	20-25
18226269-1	2008	BACKGROUND: We have recently shown that curcumin (a diferuloylmethane, the yellow pigment in turmeric) enhances apoptosis-inducing potential of TRAIL in prostate cancer PC-3 cells, and sensitizes TRAIL-resistant LNCaP cells in vitro through multiple mechanisms.	Curcumin	40-48	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	144-149
18226269-1	2008	BACKGROUND: We have recently shown that curcumin (a diferuloylmethane, the yellow pigment in turmeric) enhances apoptosis-inducing potential of TRAIL in prostate cancer PC-3 cells, and sensitizes TRAIL-resistant LNCaP cells in vitro through multiple mechanisms.	Curcumin	40-48	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	196-201
18226269-1	2008	BACKGROUND: We have recently shown that curcumin (a diferuloylmethane, the yellow pigment in turmeric) enhances apoptosis-inducing potential of TRAIL in prostate cancer PC-3 cells, and sensitizes TRAIL-resistant LNCaP cells in vitro through multiple mechanisms.	Curcumin	52-69	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	144-149
18226269-1	2008	BACKGROUND: We have recently shown that curcumin (a diferuloylmethane, the yellow pigment in turmeric) enhances apoptosis-inducing potential of TRAIL in prostate cancer PC-3 cells, and sensitizes TRAIL-resistant LNCaP cells in vitro through multiple mechanisms.	Curcumin	52-69	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	196-201
18226269-2	2008	The objectives of this study were to investigate the molecular mechanisms by which curcumin sensitized TRAIL-resistant LNCaP xenografts in vivo.	Curcumin	83-91	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	103-108
18226269-4	2008	RESULTS: Curcumin inhibited growth of LNCaP xenografts in nude mice by inducing apoptosis (TUNEL staining) and inhibiting proliferation (PCNA and Ki67 staining), and sensitized these tumors to undergo apoptosis by TRAIL.	Curcumin	9-17	antigen identified by monoclonal antibody Ki 67	Mus musculus	146-150
18226269-4	2008	RESULTS: Curcumin inhibited growth of LNCaP xenografts in nude mice by inducing apoptosis (TUNEL staining) and inhibiting proliferation (PCNA and Ki67 staining), and sensitized these tumors to undergo apoptosis by TRAIL.	Curcumin	9-17	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	214-219
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	62-67
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	BCL2-associated X protein	Mus musculus	90-93
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	100-103
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	104-108
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	cyclin-dependent kinase inhibitor 1B	Mus musculus	114-117
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	cyclin-dependent kinase inhibitor 1B	Mus musculus	118-122
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	cyclin D1	Mus musculus	195-204
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	vascular endothelial growth factor A	Mus musculus	206-210
18226269-5	2008	In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL.	Curcumin	23-31	matrix metallopeptidase 2	Mus musculus	217-222
18226269-8	2008	CONCLUSION: The ability of curcumin to inhibit tumor growth, metastasis and angiogenesis, and enhance the therapeutic potential of TRAIL suggests that curcumin alone or in combination with TRAIL can be used for prostate cancer prevention and/or therapy.	Curcumin	151-159	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	131-136
17900558-9	2007	Curcumin retarded generation of islet reactive oxygen species along with inhibition of Poly ADP-ribose polymerase-1 activation.	Curcumin	0-8	poly (ADP-ribose) polymerase family, member 1	Mus musculus	87-115
17996675-0	2007	Anti-inflammatory effect of curcumin involves downregulation of MMP-9 in blood mononuclear cells.	Curcumin	28-36	matrix metallopeptidase 9	Homo sapiens	64-69
17996675-2	2007	Here we examined the possibility of curcumin affecting the production of matrix metalloproteinases (MMPs) by peripheral blood mononuclear cells (PBMCs), which play an important role in inflammation.	Curcumin	36-44	matrix metallopeptidase 9	Homo sapiens	100-104
17996675-3	2007	Zymographic analysis and ELISA showed that curcumin significantly inhibited the activity and level of MMPs produced by PBMCs isolated from human and inflammation-induced rabbit in a concentration dependent manner.	Curcumin	43-51	matrix metallopeptidase 9	Homo sapiens	102-106
17996675-9	2007	Curcumin inhibited the degradation of IkappaB-alpha, which inhibited the ALA mediated activation of NFkappaB and upregulation of MMP-9.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	129-134
17996675-10	2007	These results indicated that anti-inflammatory effect of curcumin also involves inhibition of the production of MMP-9 in PBMCs.	Curcumin	57-65	matrix metallopeptidase 9	Homo sapiens	112-117
17973899-5	2007	Moreover, curcumin significantly inhibited pulmonary sequestration of leucocytes in response to lipopolysaccharide as evidenced by decrease of myeloperoxidase activity in lung tissue.	Curcumin	10-18	myeloperoxidase	Mus musculus	143-158
17471506-7	2007	The modulation of irradiation-induced activation of PKCdelta and NFkappaB by curcumin and the complex was found different at later time periods although the initial response was similar.	Curcumin	77-85	protein kinase C, delta	Mus musculus	52-60
17640567-5	2007	The reducing agent also counteracted the inhibitory effects of curcumin on TNF-induced NF-kappaB-regulated antiapoptotic (Bcl-2, Bcl-xL, IAP1), proliferative (cyclin D1), and proinflammatory (COX-2, iNOS, and MMP-9) gene products.	Curcumin	63-71	matrix metallopeptidase 9	Homo sapiens	209-214
17277231-8	2007	The present study demonstrates the role of Bax and Bak as a critical regulator of curcumin-induced apoptosis and over-expression of Smac as interventional approaches to deal with Bax- and/or Bak-deficient chemoresistant cancers for curcumin-based therapy.	Curcumin	82-90	BCL2-associated X protein	Mus musculus	43-46
17277231-8	2007	The present study demonstrates the role of Bax and Bak as a critical regulator of curcumin-induced apoptosis and over-expression of Smac as interventional approaches to deal with Bax- and/or Bak-deficient chemoresistant cancers for curcumin-based therapy.	Curcumin	232-240	BCL2-associated X protein	Mus musculus	43-46
17499312-9	2007	Receptor tyrosine kinase assays revealed that IGF-1-stimulated IGF-1R tyrosine kinase activation was also abrogated by curcumin in a dose-dependent manner.	Curcumin	119-127	insulin like growth factor 1 receptor	Homo sapiens	63-69
17499312-10	2007	Real-time fluorescence quantitative reverse transcriptase-polymerase chain reaction (RFQ-RT-PCR) further revealed that curcumin suppressed IGF-1R gene expression at transcriptional level.	Curcumin	119-127	insulin like growth factor 1 receptor	Homo sapiens	139-145
17531121-0	2007	Effects of curcumin on peroxisome proliferator-activated receptor gamma expression and nuclear translocation/redistribution in culture-activated rat hepatic stellate cells.	Curcumin	11-19	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	23-71
17531121-3	2007	In this study, the effects of curcumin on the proliferation, activation and apoptosis of rat hepatic stellate cells (HSCs) through PPARgamma signaling were investigated.	Curcumin	30-38	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	131-140
17531121-15	2007	Curcumin up-regulated PPARgamma expression and significantly inhibited the production of alpha-SMA and collagen I.	Curcumin	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	22-31
17531121-16	2007	PPARgamma is expressed in the cytoplasm and nucleus and is evenly distributed in HSCs, but accumulated in the nucleus of HSCs and disappeared from cytoplasm after curcumin treatment.	Curcumin	163-171	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	0-9
17531121-19	2007	The activities of MMP-2 and MMP-9 were enhanced significantly by curcumin.	Curcumin	65-73	matrix metallopeptidase 9	Rattus norvegicus	28-33
17531121-20	2007	CONCLUSIONS: Curcumin can inhibit the proliferation and activation of HSCs, induce the apoptosis of activated HSCs and enhance the activities of MMP-2 and MMP-9.	Curcumin	13-21	matrix metallopeptidase 9	Rattus norvegicus	155-160
17531121-21	2007	The effects of curcumin are mediated through activating the PPARgamma signal transduction pathway and associated with PPARgamma nuclear translocation/redistribution.	Curcumin	15-23	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	60-69
17531121-21	2007	The effects of curcumin are mediated through activating the PPARgamma signal transduction pathway and associated with PPARgamma nuclear translocation/redistribution.	Curcumin	15-23	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	118-127
17372590-0	2007	The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro.	Curcumin	59-67	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	98-107
17372590-3	2007	We recently showed that curcumin, the yellow pigment in curry, inhibited cell growth and induced gene expression of endogenous PPARgamma in activated HSC in vitro.	Curcumin	24-32	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	127-136
17372590-5	2007	It is hypothesized that the interruption of the PDGF and EGF signaling pathways by curcumin might stimulate gene expression of PPARgamma in activated HSC.	Curcumin	83-91	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	127-136
17332930-8	2007	Furthermore, curcumin inhibited expression of phosphatidyl-inositol-3 kinase (PI3K) p110 and p85 subunits, and phosphorylation of Ser 473 AKT/PKB.	Curcumin	13-21	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	93-96
17633203-0	2007	Effect of curcumin on the induction of glutathione S-transferases and NADP(H):quinone oxidoreductase and its possible mechanism of action.	Curcumin	10-18	2,4-dienoyl-CoA reductase 1	Homo sapiens	70-100
17633203-1	2007	This study is to investigate the effect of curcumin on the induction of glutathione S-transferases (GST) and NADP(H):quinone oxidoreductase (NQO) and explore their possible molecular mechanism.	Curcumin	43-51	2,4-dienoyl-CoA reductase 1	Homo sapiens	109-139
17303007-6	2007	RESULTS: Curcumin downregulated the expression of NKX3.1 and the activity of the NKX3.1 1040 bp promoter in LNCaP cells.	Curcumin	9-17	NK3 homeobox 1	Homo sapiens	50-56
17303007-6	2007	RESULTS: Curcumin downregulated the expression of NKX3.1 and the activity of the NKX3.1 1040 bp promoter in LNCaP cells.	Curcumin	9-17	NK3 homeobox 1	Homo sapiens	81-87
17303007-9	2007	CONCLUSION: Curcumin could downregulate NKX3.1 expression in LNCaP cells.	Curcumin	12-20	NK3 homeobox 1	Homo sapiens	40-46
17332326-3	2007	Curcumin down-regulates MDM2, independent of p53.	Curcumin	0-8	MDM2 proto-oncogene	Homo sapiens	24-28
17332326-4	2007	In a human prostate cancer cell lines PC3 (p53(null)), curcumin reduced MDM2 protein and mRNA in a dose- and time-dependent manner, and enhanced the expression of the tumor suppressor p21(Waf1/CIP1).	Curcumin	55-63	MDM2 proto-oncogene	Homo sapiens	72-76
17332326-8	2007	When it was administered to tumor-bearing nude mice, curcumin inhibited growth of PC3 xenografts and enhanced the antitumor effects of gemcitabine and radiation.	Curcumin	53-61	proprotein convertase subtilisin/kexin type 1	Mus musculus	82-85
17332326-9	2007	In these tumors, curcumin reduced the expression of MDM2.	Curcumin	17-25	MDM2 proto-oncogene	Homo sapiens	52-56
17332326-10	2007	Down-regulation of the MDM2 oncogene by curcumin is a novel mechanism of action that may be essential for its chemopreventive and chemotherapeutic effects.	Curcumin	40-48	MDM2 proto-oncogene	Homo sapiens	23-27
17332326-11	2007	Our observations help to elucidate the process by which mitogens up-regulate MDM2, independent of p53, and identify a mechanism by which curcumin functions as an anticancer agent.	Curcumin	137-145	MDM2 proto-oncogene	Homo sapiens	77-81
17196622-11	2007	Among the active spice-derived components studied, allyl isothiocyanate, zingerone, and curcumin significantly inhibited the cellular production of proinflammatory mediators such as TNF-alpha and nitric oxide, and significantly inhibited the release of MCP-1 from 3T3-L1 adipocytes.	Curcumin	88-96	chemokine (C-C motif) ligand 2	Mus musculus	253-258
17184589-0	2007	Curcumin synergistically augments bcr/abl phosphorothioate antisense oligonucleotides to inhibit growth of chronic myelogenous leukemia cells.	Curcumin	0-8	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	34-41
16959952-0	2007	Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells.	Curcumin	59-67	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	95-143
16959952-3	2007	We previously demonstrated that curcumin induced gene expression of PPAR-gamma in activated HSC, leading to reducing cell proliferation, inducing apoptosis and suppressing expression of extracellular matrix genes.	Curcumin	32-40	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	68-78
16959952-8	2007	The present report demonstrates that exogenous TGF-beta1 inhibits gene expression of PPAR-gamma in activated HSC, which is eliminated by the pretreatment with curcumin likely by interrupting TGF-beta signaling.	Curcumin	159-167	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	85-95
16959952-10	2007	Promoter deletion assays, site-directed mutageneses, and gel shift assays localize two Smad binding elements (SBEs) in the PPAR-gamma gene promoter, acting as curcumin response elements and negatively regulating the promoter activity in passaged HSC.	Curcumin	159-167	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	123-133
16959952-12	2007	Overexpression of Smad4 dose dependently eliminates the inhibitory effects of curcumin on the PPAR-gamma gene promoter and TGF-beta signaling.	Curcumin	78-86	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	94-104
16959952-13	2007	Taken together, these results demonstrate that the interruption of TGF-beta signaling by curcumin induces gene expression of PPAR-gamma in activated HSC in vitro.	Curcumin	89-97	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	125-135
16959952-14	2007	Our studies provide novel insights into the molecular mechanisms of curcumin in the induction of PPAR-gamma gene expression and in the inhibition of HSC activation.	Curcumin	68-76	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	97-107
17710245-8	2007	These data suggest that curcumin induces the stacking of the Rab11 vesicle complex with CXCR1 and CXCR2 in the endocytic pathway.	Curcumin	24-32	C-X-C motif chemokine receptor 1	Homo sapiens	88-93
16959222-3	2006	In our hands, curcumin treatment induced a decrease of nuclear STAT3, -5a and -5b, without affecting neither STAT1, nor the phosphorylation state of STAT1, -3 or -5 in the K562 cell line.	Curcumin	14-22	signal transducer and activator of transcription 1	Homo sapiens	109-114
17022948-0	2006	Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB.	Curcumin	0-8	brain-derived neurotrophic factor	Rattus norvegicus	75-79
17022948-9	2006	Furthermore, these stress-induced decreases in BDNF and pCREB/CREB were also blocked by chronic curcumin administration (5 or 10 mg/kg, p.o.).	Curcumin	96-104	brain-derived neurotrophic factor	Rattus norvegicus	47-51
16934760-5	2006	In the present study, a library of analogs of curcumin was screened for activity against the TPA-induced activation of AP-1 using the Panomics AP-1 Reporter 293 stable cell line which is designed for screening potential inhibitors.	Curcumin	46-54	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	143-147
17041101-7	2006	Analysis of the effects of the analogues on the expression of cancer-related genes usually affected by curcumin indicated that some induced the down-regulation of beta-catenin, Ki-ras, cyclin D1, c-Myc, and ErbB-2 at as low as one eighth the concentration at which curcumin normally has an effect.	Curcumin	265-273	KRAS proto-oncogene, GTPase	Homo sapiens	177-183
16867261-0	2006	Curcumin regulated shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis.	Curcumin	0-8	negative elongation factor complex member C/D	Homo sapiens	30-33
16779518-7	2006	Curcumin-treated mice also exhibited relative decreases in aortic tissue activator protein-1 and nuclear factor kappaB DNA binding activities and significantly lower aortic tissue concentrations of interleukin-1beta (IL-1beta), IL-6, monocyte chemoattractant protein-1, and matrix metalloproteinase-9 (all p &lt; 0.05).	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	234-268
16406419-0	2006	Effect of curcumin on the expression of LDL receptor in mouse macrophages.	Curcumin	10-18	low density lipoprotein receptor	Mus musculus	40-52
16406419-3	2006	Here for the first time, we found that curcumin obviously up-regulated the expression of LDL receptor in mouse macrophages, and the dose-effect relationship was demonstrated.	Curcumin	39-47	low density lipoprotein receptor	Mus musculus	89-101
16297412-7	2006	Additionally, following 2 weeks of curcumin at 400 mg/kg, there was a 20% decrease in the catalytic activity and a 28% decrease in polypeptide levels of CYP3A.	Curcumin	35-43	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	153-158
16297412-9	2006	In conclusion small changes in CYP1A, CYP3A and GST following long term treatment (2 weeks) suggest that the combination of all three metabolic pathways may play a small role in curcumin"s chemopreventative action.	Curcumin	178-186	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	38-43
16368150-10	2006	AP-1-specific inhibitor Curcumin dose-dependently abrogated the effect of IL-18 on VEGF production.	Curcumin	24-32	interleukin 18	Homo sapiens	74-79
16528793-0	2006	Curcumin analogs as potent aldose reductase inhibitors.	Curcumin	0-8	aldose reductase	Bos taurus	27-43
16528793-2	2006	In order to find more potent aldose reductase inhibitor, curcumin analogs were synthesized and evaluated for their ability to inhibit bovine lens aldose reductase enzyme.	Curcumin	57-65	aldose reductase	Bos taurus	29-45
16528793-2	2006	In order to find more potent aldose reductase inhibitor, curcumin analogs were synthesized and evaluated for their ability to inhibit bovine lens aldose reductase enzyme.	Curcumin	57-65	aldose reductase	Bos taurus	146-162
16528793-4	2006	The structure-activity relationship revealed that the curcumin analogs with ortho-dihydroxyl groups could form a more tight affinity with aldose reductase to exert more potential inhibitory activities.	Curcumin	54-62	aldose reductase	Bos taurus	138-154
16364299-7	2006	Supplementation of curcumin in the diet dramatically reduced oxidative damage and normalized levels of BDNF, synapsin I, and CREB that had been altered after TBI.	Curcumin	19-27	brain-derived neurotrophic factor	Rattus norvegicus	103-107
16364299-7	2006	Supplementation of curcumin in the diet dramatically reduced oxidative damage and normalized levels of BDNF, synapsin I, and CREB that had been altered after TBI.	Curcumin	19-27	synapsin I	Rattus norvegicus	109-119
16454490-6	2006	This curcumin-loaded PLLA material was then modified using adsorptive coating of adhesive proteins such as fibronectin, collagen-I, vitronectin, laminin, and matrigel to improve the endothelial cell (EC) adhesion and proliferation, and ECs were seeded on top of these modified surfaces.	Curcumin	5-13	vitronectin	Homo sapiens	132-143
31394642-0	2006	Down-regulation of Cdc25c, CDK1 and Cyclin B1 and Up-regulation of Wee1 by Curcumin Promotes Human Colon Cancer Colo 205 Cell Entry into G2/M-phase of Cell Cycle.	Curcumin	75-83	WEE1 G2 checkpoint kinase	Homo sapiens	67-71
31394642-6	2006	Futhermore, curcumin induced Wee1 expression and decreased the Cdc25c, cyclin B1 and CDK1 expressions, resulting in the induction of G2/M cell cycle arrest in the colo 205 cells.	Curcumin	12-20	WEE1 G2 checkpoint kinase	Homo sapiens	29-33
31394642-8	2006	CONCLUSION: The results indicate that curcumin promoted the gene expression of Wee1 and inhibited that of Cdc25c, CDK1 and cyclin B1.	Curcumin	38-46	WEE1 G2 checkpoint kinase	Homo sapiens	79-83
16389264-7	2006	Curcumin treatment resulted not only in a significant reduction in the expression of MMP-2 and MMP-9, but also effected the inhibition of invasive ability in vitro.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	95-100
16389264-8	2006	Curcumin was shown to induce a marked reduction of tumor volume, MMP-2, and MMP-9 activity in the tumor-bearing site.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	76-81
16252242-0	2005	Curcumin treatment abrogates endoplasmic reticulum retention and aggregation-induced apoptosis associated with neuropathy-causing myelin protein zero-truncating mutants.	Curcumin	0-8	myelin protein zero	Homo sapiens	130-149
16252242-5	2005	Curcumin, a chemical compound derived from the curry spice tumeric, releases the ER-retained MPZ mutants into the cytoplasm accompanied by a lower number of apoptotic cells.	Curcumin	0-8	myelin protein zero	Homo sapiens	93-96
16356124-2	2005	In the present study, we investigated the possible inhibitory effects of curcumin on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in MCF10A human breast epithelial (MCF10A) cells and the underlying mechanisms.	Curcumin	73-81	matrix metallopeptidase 9	Homo sapiens	113-118
16356124-8	2005	Taken together, these findings suggest that curcumin inhibits the TPA-induced up-regulation of COX-2 and MMP-9 by suppressing ERK1/2 phosphorylation and NF-kappaB trans-activation in human breast epithelial cells, which may contribute to its chemopreventive potential.	Curcumin	44-52	matrix metallopeptidase 9	Homo sapiens	105-110
16243823-5	2005	Curcumin also suppressed the paclitaxel-induced expression of antiapoptotic (XIAP, IAP-1, IAP-2, Bcl-2, and Bcl-xL), proliferative (cyclooxygenase 2, c-Myc, and cyclin D1), and metastatic proteins (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1).	Curcumin	0-8	X-linked inhibitor of apoptosis	Homo sapiens	77-81
16243823-5	2005	Curcumin also suppressed the paclitaxel-induced expression of antiapoptotic (XIAP, IAP-1, IAP-2, Bcl-2, and Bcl-xL), proliferative (cyclooxygenase 2, c-Myc, and cyclin D1), and metastatic proteins (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1).	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	234-260
16243823-5	2005	Curcumin also suppressed the paclitaxel-induced expression of antiapoptotic (XIAP, IAP-1, IAP-2, Bcl-2, and Bcl-xL), proliferative (cyclooxygenase 2, c-Myc, and cyclin D1), and metastatic proteins (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1).	Curcumin	0-8	intercellular adhesion molecule 1	Homo sapiens	266-300
16243823-7	2005	In a human breast cancer xenograft model, dietary administration of curcumin significantly decreased the incidence of breast cancer metastasis to the lung and suppressed the expression of NF-kappaB, cyclooxygenase 2, and matrix metalloproteinase-9.	Curcumin	68-76	matrix metallopeptidase 9	Homo sapiens	221-247
16102725-4	2005	The inhibitory effect of curcumin on MMP-9 expression correlates with the decreased MMP-9 mRNA level and the suppression of MMP-9 promoter activity.	Curcumin	25-33	matrix metallopeptidase 9	Homo sapiens	84-89
16102725-5	2005	The curcumin-mediated inhibition of MMP-9 gene expression appears to occur via NF-kappaB and AP-1 because their DNA binding activities were suppressed by curcumin.	Curcumin	4-12	matrix metallopeptidase 9	Homo sapiens	36-41
16102725-5	2005	The curcumin-mediated inhibition of MMP-9 gene expression appears to occur via NF-kappaB and AP-1 because their DNA binding activities were suppressed by curcumin.	Curcumin	154-162	matrix metallopeptidase 9	Homo sapiens	36-41
16102725-7	2005	Therefore, the inhibition of MMP-9 expression by curcumin might have therapeutic potential for controlling the growth and invasiveness of brain tumor.	Curcumin	49-57	matrix metallopeptidase 9	Homo sapiens	29-34
16173963-7	2005	BAY 11-7082- and curcumin-induced cell death was associated with downregulation of Bcl-xL, cyclin D1, XIAP and c-FLIP, followed by caspase-8, poly(ADP-ribose) polymerase cleavage and activation.	Curcumin	17-25	X-linked inhibitor of apoptosis	Homo sapiens	102-106
16132679-5	2005	The addition of curcumin, nicotinamide and Jun N-terminal kinase (JNK) inhibitor, SP 600125, reduced the levels of NO, iNOS expression and nitration of proteins in macrophages.	Curcumin	16-24	mitogen-activated protein kinase 8	Mus musculus	66-69
16132679-7	2005	Curcumin and JNK inhibitor directly inhibited the nitration of proteins and JNK inhibitor and curcumin, when added together, did not show synergistic effect.	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	76-79
16132679-7	2005	Curcumin and JNK inhibitor directly inhibited the nitration of proteins and JNK inhibitor and curcumin, when added together, did not show synergistic effect.	Curcumin	94-102	mitogen-activated protein kinase 8	Mus musculus	13-16
16053715-0	2005	Curcumin derivatives inhibit the formation of Jun-Fos-DNA complex independently of their conserved cysteine residues.	Curcumin	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-53
16053715-1	2005	Curcumin, a major active component of turmeric, has been identified as an inhibitor of the transcriptional activity of activator protein-1 (AP-1).	Curcumin	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-144
16053715-2	2005	Recently, it was also found that curcumin and synthetic curcumin derivatives can inhibit the binding of Jun-Fos, which are the members of the AP-1 family, to DNA.	Curcumin	33-41	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	108-111
16053715-2	2005	Recently, it was also found that curcumin and synthetic curcumin derivatives can inhibit the binding of Jun-Fos, which are the members of the AP-1 family, to DNA.	Curcumin	33-41	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	142-146
16053715-2	2005	Recently, it was also found that curcumin and synthetic curcumin derivatives can inhibit the binding of Jun-Fos, which are the members of the AP-1 family, to DNA.	Curcumin	56-64	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	108-111
16053715-2	2005	Recently, it was also found that curcumin and synthetic curcumin derivatives can inhibit the binding of Jun-Fos, which are the members of the AP-1 family, to DNA.	Curcumin	56-64	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	142-146
16053715-5	2005	However, the inhibitory mechanism of curcumin and its derivatives, unlike that of other Jun-Fos inhibitors, was found to be independent of these conserved cysteine residues.	Curcumin	37-45	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	92-95
16053715-6	2005	In addition, we investigated whether curcumin derivatives can inhibit AP-1 transcriptional activity in vivo using a luciferase assay.	Curcumin	37-45	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	70-74
16053715-7	2005	We found that, among the curcumin derivatives examined, only inhibitors shown to inhibit the binding of Jun-Fos to DNA by Electrophoretic Mobility Shift Assay (EMSA) inhibited AP-1 transcriptional activity in vivo.	Curcumin	25-33	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	108-111
16053715-7	2005	We found that, among the curcumin derivatives examined, only inhibitors shown to inhibit the binding of Jun-Fos to DNA by Electrophoretic Mobility Shift Assay (EMSA) inhibited AP-1 transcriptional activity in vivo.	Curcumin	25-33	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	176-180
16053715-8	2005	Moreover, RT-PCR revealed that curcumin derivatives, like curcumin, downregulated c-jun mRNA in JB6 cells.	Curcumin	31-39	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	82-87
16053715-8	2005	Moreover, RT-PCR revealed that curcumin derivatives, like curcumin, downregulated c-jun mRNA in JB6 cells.	Curcumin	58-66	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	82-87
15982617-9	2005	Curcumin, a specific inhibitor of JNK, also concentration-dependently reduced IL-17--induced IL-8 production, with a maximal decrease of 82+/-4% (n=8, p&lt;0.01).	Curcumin	0-8	interleukin 17A	Homo sapiens	78-83
15949703-0	2005	Suppressive effects of dietary curcumin on the increased activity of renal ornithine decarboxylase in mice treated with a renal carcinogen, ferric nitrilotriacetate.	Curcumin	31-39	ornithine decarboxylase, structural 1	Mus musculus	75-98
15949703-11	2005	The ODC activity in the kidney was significantly increased by Fe-NTA, while the increased ODC activity induced by Fe-NTA was normalized in curcumin-pretreated mice.	Curcumin	139-147	ornithine decarboxylase, structural 1	Mus musculus	90-93
15569263-7	2004	We found that curcumin inhibited Abeta1-40-induced MAP kinase activation and the phosphorylation of ERK-1/2 and its downstream target Elk-1.	Curcumin	14-22	ETS transcription factor ELK1	Homo sapiens	134-139
15569263-8	2004	We observed that curcumin inhibited Abeta1-40-induced expression of CCR5 but not of CCR2b in THP-1 cells.	Curcumin	17-25	C-C motif chemokine receptor 5	Homo sapiens	68-72
15569263-9	2004	This involved abrogation of Egr-1 DNA binding in the promoter of CCR5 by curcumin as determined by: (i) electrophoretic mobility shift assay, (ii) transfection studies with truncated CCR5 gene promoter constructs, and (iii) chromatin immunoprecipitation analysis.	Curcumin	73-81	C-C motif chemokine receptor 5	Homo sapiens	65-69
15569263-9	2004	This involved abrogation of Egr-1 DNA binding in the promoter of CCR5 by curcumin as determined by: (i) electrophoretic mobility shift assay, (ii) transfection studies with truncated CCR5 gene promoter constructs, and (iii) chromatin immunoprecipitation analysis.	Curcumin	73-81	C-C motif chemokine receptor 5	Homo sapiens	183-187
15345140-2	2004	We have recently shown that both curcumin and caffeic acid phenethyl ester, two phenolic natural compounds, potently induce HO-1 expression and activity in rat astrocytes.	Curcumin	33-41	heme oxygenase 1	Rattus norvegicus	124-128
15464445-3	2004	Although other laboratories have not been able to confirm the initial observations, activating DeltaF508 CFTR could have such important therapeutic implications that a thorough investigation of the potential of curcumin is warranted.	Curcumin	211-219	cystic fibrosis transmembrane conductance regulator	Mus musculus	105-109
15325250-3	2004	Curcumin had a small effect on basal (non-CFTR-mediated) chloride efflux in CFBE and CF nasal epithelial cells, but did not increase the net cAMP-activated (CFTR-mediated) chloride efflux.	Curcumin	0-8	cystic fibrosis transmembrane conductance regulator	Mesocricetus auratus	42-46
15325250-4	2004	Curcumin caused a small increase in net cAMP-activated chloride efflux from DeltaF508-CFTR BHK cells.	Curcumin	0-8	cystic fibrosis transmembrane conductance regulator	Mesocricetus auratus	86-90
15358181-1	2004	In a previous study, we observed that some synthetic curcumin analogs inhibited complex formations between Fos-Jun heterodimer and activator protein-1 (AP-1) DNA.	Curcumin	53-61	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-110
15358181-1	2004	In a previous study, we observed that some synthetic curcumin analogs inhibited complex formations between Fos-Jun heterodimer and activator protein-1 (AP-1) DNA.	Curcumin	53-61	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	131-150
15358181-1	2004	In a previous study, we observed that some synthetic curcumin analogs inhibited complex formations between Fos-Jun heterodimer and activator protein-1 (AP-1) DNA.	Curcumin	53-61	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	152-156
15358181-2	2004	These curcumin analogs have been observed to repress the AP-1 transcription in AP-1-transfected cells and they also inhibited the increased expression of Jun/AP-1 protein by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the same cells.	Curcumin	6-14	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-61
15358181-2	2004	These curcumin analogs have been observed to repress the AP-1 transcription in AP-1-transfected cells and they also inhibited the increased expression of Jun/AP-1 protein by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the same cells.	Curcumin	6-14	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-83
15358181-2	2004	These curcumin analogs have been observed to repress the AP-1 transcription in AP-1-transfected cells and they also inhibited the increased expression of Jun/AP-1 protein by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the same cells.	Curcumin	6-14	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	79-83
15358181-3	2004	After the AP-1 inhibition by curcumin analogs in TPA-treated HT-1080 human fibrosarcoma cells, a decrease in mRNA expression of c-jun and MMP3 (stromelysin-1) has been observed.	Curcumin	29-37	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	10-14
15358181-3	2004	After the AP-1 inhibition by curcumin analogs in TPA-treated HT-1080 human fibrosarcoma cells, a decrease in mRNA expression of c-jun and MMP3 (stromelysin-1) has been observed.	Curcumin	29-37	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	128-133
15358181-4	2004	We also observed that curcumin analogs down-regulated the expression of MMP-9 (gelatinase-B), correlating with cellular invasion and migration in conditions such as tumor invasion and metastasis, through the electrophoretic mobility shift assay and gelatin zymography methods.	Curcumin	22-30	matrix metallopeptidase 9	Homo sapiens	72-77
15358181-6	2004	Through the reverse transcriptase-polymerase chain reaction experiment, we confirmed that curcumin analogs down-regulated the expression of angiogenesis-associated genes, VEGF and MMP-9.	Curcumin	90-98	matrix metallopeptidase 9	Homo sapiens	180-185
15194816-8	2004	The stretch-induced augmentation of both IL-8 and MCP-3 expression was significantly suppressed by an activator protein-1 (AP-1) inhibitor, curcumin.	Curcumin	140-148	C-C motif chemokine ligand 7	Homo sapiens	50-55
14742295-3	2004	This effect is likely to be linked to the fact that although curcumin induces the expression of the phase 2 detoxification enzymes heme oxygenase 1 and glutathione S-transferase P1 (GST P1) in NLF, SLF are deficient in these enzymes, particularly after curcumin treatment.	Curcumin	61-69	heme oxygenase 1	Rattus norvegicus	131-147
14701837-7	2004	Addition of curcumin to neuro 2a cells induces a rapid decrease in mitochondrial membrane potential and the release of cytochrome c into cytosol, followed by activation of caspase-9 and caspase-3.	Curcumin	12-20	caspase 3	Mus musculus	186-195
14637190-2	2003	In this study, we observed that curcumin inhibited the kinase activity of v-Src, which led to a decrease in tyrosyl substrate phosphorylation of Shc, cortactin, and FAK.	Curcumin	32-40	SHC adaptor protein 1	Homo sapiens	145-148
14637190-2	2003	In this study, we observed that curcumin inhibited the kinase activity of v-Src, which led to a decrease in tyrosyl substrate phosphorylation of Shc, cortactin, and FAK.	Curcumin	32-40	cortactin	Homo sapiens	150-159
14597230-0	2003	Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction.	Curcumin	143-151	amyloid beta precursor like protein 1	Homo sapiens	74-79
14597230-9	2003	Surprisingly, curcumin had differential effects on the APLP protein levels in RA-differentiated cells.	Curcumin	14-22	amyloid beta precursor like protein 1	Homo sapiens	55-59
14597230-10	2003	RA-induced APLP1 protein expression was blocked by curcumin, while the APLP2 protein levels were further increased.	Curcumin	51-59	amyloid beta precursor like protein 1	Homo sapiens	11-16
12807725-0	2003	Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	202-207
12792803-0	2003	Structure of curcumin in complex with lipoxygenase and its significance in cancer.	Curcumin	13-21	linoleate 9S-lipoxygenase-4	Glycine max	38-50
12792803-3	2003	This work delivers the first 3D structural data and explains how curcumin interacts with the fatty acid metabolizing enzyme, soybean lipoxygenase.	Curcumin	65-73	linoleate 9S-lipoxygenase-4	Glycine max	133-145
12792803-4	2003	Curcumin binds to lipoxygenase in a non-competitive manner.	Curcumin	0-8	linoleate 9S-lipoxygenase-4	Glycine max	18-30
12781211-0	2003	Curcumin inhibited the arylamines N-acetyltransferase activity, gene expression and DNA adduct formation in human lung cancer cells (A549).	Curcumin	0-8	bromodomain containing 2	Homo sapiens	34-53
12781211-4	2003	The NAT activity in the human A549 cells and cytosols was suppressed by curcumin in a dose-dependent manner.	Curcumin	72-80	bromodomain containing 2	Homo sapiens	4-7
12473670-12	2003	Most importantly, curcumin suppressed the OPN-induced tumor growth in nude mice, and the levels of pro-MMP-2 expression and activation in OPN-induced tumor were inhibited by curcumin.	Curcumin	174-182	matrix metallopeptidase 2	Mus musculus	103-108
12473670-13	2003	To our knowledge, this is the first report that OPN induces NF kappa B activity through phosphorylation and degradation of I kappa B alpha by activating IKK that ultimately triggers the activation of pro-MMP-2 and further demonstrates that curcumin potently suppresses OPN-induced cell migration, tumor growth, and NF kappa B-mediated pro-MMP-2 activation by blocking the IKK/I kappa B alpha signaling pathways.	Curcumin	240-248	matrix metallopeptidase 2	Mus musculus	204-209
12473670-13	2003	To our knowledge, this is the first report that OPN induces NF kappa B activity through phosphorylation and degradation of I kappa B alpha by activating IKK that ultimately triggers the activation of pro-MMP-2 and further demonstrates that curcumin potently suppresses OPN-induced cell migration, tumor growth, and NF kappa B-mediated pro-MMP-2 activation by blocking the IKK/I kappa B alpha signaling pathways.	Curcumin	240-248	matrix metallopeptidase 2	Mus musculus	339-344
12646172-2	2003	Likewise, bilirubin-UGT1A1 expressed in COS-1 cells was inhibited by curcumin and calphostin-C.	Curcumin	69-77	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	20-26
12527329-3	2003	After pre-treatment of cells for 20 min, curcumin (40 microM) inhibited EGF-stimulated phosphorylation of the EGFR in MDA-MB-468 cells and phosphorylation of extracellular signal regulated kinases (ERKs) 1 and 2, as well as ERK activity and levels of nuclear c-fos in both cell lines.	Curcumin	41-49	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	259-264
12488237-4	2003	In both cerulein pancreatitis and pancreatitis induced by a combination of ethanol diet and low-dose CCK, curcumin improved the severity of the disease as measured by a number of parameters (histology, serum amylase, pancreatic trypsin, and neutrophil infiltration).	Curcumin	106-114	cholecystokinin	Rattus norvegicus	101-104
12488237-6	2003	Curcumin also blocked CCK-induced NF-kappaB and AP-1 activation in isolated pancreatic acini.	Curcumin	0-8	cholecystokinin	Rattus norvegicus	22-25
12678405-5	2003	The binding to fibronectin, vitronectin, and collagen IV decreased by over 50% in 24 hours, and by 100% after 48 hours of curcumin treatment, it persisted at this level even after 15 days of cultivating cells in curcumin-free medium.	Curcumin	122-130	vitronectin	Mus musculus	28-39
12678405-5	2003	The binding to fibronectin, vitronectin, and collagen IV decreased by over 50% in 24 hours, and by 100% after 48 hours of curcumin treatment, it persisted at this level even after 15 days of cultivating cells in curcumin-free medium.	Curcumin	212-220	vitronectin	Mus musculus	28-39
12359244-10	2002	Our results on Northern blot analysis clearly indicated a time-dependent (0-24h) inhibition by curcumin of VEGF, angiopoietin 1 and 2 gene expression in EAT cells, VEGF and angiopoietin 1 gene expression in NIH3T3 cells, and KDR gene expression in HUVECs.	Curcumin	95-103	vascular endothelial growth factor A	Mus musculus	107-111
12359244-10	2002	Our results on Northern blot analysis clearly indicated a time-dependent (0-24h) inhibition by curcumin of VEGF, angiopoietin 1 and 2 gene expression in EAT cells, VEGF and angiopoietin 1 gene expression in NIH3T3 cells, and KDR gene expression in HUVECs.	Curcumin	95-103	vascular endothelial growth factor A	Mus musculus	164-168
12359244-11	2002	Further, decreased VEGF levels in conditioned media from cells treated with various doses of curcumin (1 microM-1mM) for various time periods (0-24h) confirm its angioinhibitory action at the level of gene expression.	Curcumin	93-101	vascular endothelial growth factor A	Mus musculus	19-23
12105223-7	2002	Curcumin, but not PD98059 or SB203580, inhibited IL-1 beta-mediated suppression of nuclear RXR:RAR binding activity, which correlated with inhibition of JNK phosphorylation and phospho-JNK-mediated phosphorylation of RXR.	Curcumin	0-8	retinoid X receptor alpha	Homo sapiens	91-94
12105223-7	2002	Curcumin, but not PD98059 or SB203580, inhibited IL-1 beta-mediated suppression of nuclear RXR:RAR binding activity, which correlated with inhibition of JNK phosphorylation and phospho-JNK-mediated phosphorylation of RXR.	Curcumin	0-8	retinoid X receptor alpha	Homo sapiens	217-220
12105223-8	2002	Taken together, these data provide evidence supporting a novel player (JNK), as well as its inhibitor (curcumin), in inflammation-mediated regulation of hepatobiliary transporters and correlate JNK-dependent RXR phosphorylation with reduced RXR-dependent hepatic gene expression.	Curcumin	103-111	retinoid X receptor alpha	Homo sapiens	208-211
12055272-7	2002	In vitro treatment of activated T cells with curcumin inhibited IL-12-induced tyrosine phosphorylation of Janus kinase 2, tyrosine kinase 2, and STAT3 and STAT4 transcription factors.	Curcumin	45-53	signal transducer and activator of transcription 4	Mus musculus	155-160
11751895-7	2002	Similarly, a selective mitogen-activated protein kinase (MAPK) kinase (MEK)1/2 inhibitor (PD98059) and c-jun/activator protein (AP)-1 inhibitor (curcumin) suppressed MMP-13 mRNA up-regulation induced by MIF.	Curcumin	145-153	matrix metallopeptidase 13	Rattus norvegicus	166-172
12674762-4	2002	It was found that when HL-60 cells were treated with 25 mumol/L curcumin for 24 h, the expression level of Mcl-1 was down-regulated, but that of Bax and Bak up-regulated time-dependently.	Curcumin	64-72	BCL2 antagonist/killer 1	Homo sapiens	153-156
12674762-5	2002	There was significant difference in the expression level of Mcl-1, Bax and Bak between the curcumin-treated groups and control group (P &lt; 0.05-0.01).	Curcumin	91-99	BCL2 antagonist/killer 1	Homo sapiens	75-78
12674762-6	2002	At the same time, curcumin had no effect on progress of cell cycle in primaty acute myelogenous leukemia at newly diagnosis, but could increase the peak of Sub-G1 (P &lt; 0.05), and down-regulate the expression of Mcl-1 and up-regulate the expression of Bax and Bak with the difference being statistically significant.	Curcumin	18-26	BCL2 antagonist/killer 1	Homo sapiens	262-265
12674762-7	2002	The expression of P27kipl, P21wafl and pRbp- were elevated and that of cyclin D3 decreased in the presence of curcumin.	Curcumin	110-118	retinol binding protein 4	Homo sapiens	39-43
11716543-9	2001	In addition, our results indicate that curcumin also blocks the NF-kappaB cell survival pathway and suppresses the apoptotic inhibitor, XIAP.	Curcumin	39-47	X-linked inhibitor of apoptosis	Homo sapiens	136-140
11795474-5	2001	Sensitivity of the cancer cell lines to curcumin correlated with the generation of superoxide radicals as determined by the reduction of ferricytochrome C. Curcumin-resistant tumor cell lines showed significantly higher production of Hsp70, thus mounting a stress response and protecting the cells from the apoptotic cell death.	Curcumin	40-48	heat shock protein family A (Hsp70) member 4	Homo sapiens	234-239
11795474-5	2001	Sensitivity of the cancer cell lines to curcumin correlated with the generation of superoxide radicals as determined by the reduction of ferricytochrome C. Curcumin-resistant tumor cell lines showed significantly higher production of Hsp70, thus mounting a stress response and protecting the cells from the apoptotic cell death.	Curcumin	156-164	heat shock protein family A (Hsp70) member 4	Homo sapiens	234-239
11544338-5	2001	The results showed that curcumin levels &gt; or =30 microM profoundly inhibited isopentenyl pyrophosphate-induced release of the chemokines macrophage inflammatory protein-1alpha and -1beta and RANTES.	Curcumin	24-32	C-C motif chemokine ligand 5	Homo sapiens	194-200
11544338-7	2001	Commencing around 16 h, treatment with curcumin lead to the induction of cell death that could not be reversed by APC, IL-15, or IL-2.	Curcumin	39-47	interleukin 15	Homo sapiens	119-124
11466328-12	2001	Curcumin, a pharmacological inhibitor of the JNK-AP-1 pathway, abrogated the induction of MCP-1 by MG132.	Curcumin	0-8	mitogen-activated protein kinase 8	Mus musculus	45-48
11466328-12	2001	Curcumin, a pharmacological inhibitor of the JNK-AP-1 pathway, abrogated the induction of MCP-1 by MG132.	Curcumin	0-8	chemokine (C-C motif) ligand 2	Mus musculus	90-95
11322764-4	2001	Exposure to Stx1 and Stx2, 100 ng/ml, reduced cell viability to approximately 25% of control values after 24 h and 20 microM curcumin restored viability to nearly 75% of control.	Curcumin	125-133	syntaxin 2	Homo sapiens	21-25
11322764-8	2001	Addition of 20 microM curcumin decreased the extent of apoptosis and necrosis to 2.9 +/- 2.0 and 3.8 +/- 0.2%, respectively in the presence of Stx1 and to 3.0 +/- 2.1 and 3.9 +/- 0.3%, respectively, for Stx2 (P &lt; 0.01).	Curcumin	22-30	syntaxin 2	Homo sapiens	203-207
11322764-10	2001	The protective effect of curcumin against Stx1 and Stx2-induced injury to HK-2 was not related to its antioxidant properties.	Curcumin	25-33	syntaxin 2	Homo sapiens	51-55
11053056-6	2000	Furthermore, treatment with either PD098059, SB203580, or the JNK-AP-1 inhibitor curcumin diminished the expression of MCP-1 and stromelysin.	Curcumin	81-89	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-70
11038236-3	2000	Immunoblotting analysis showed that CCM strongly inhibited DEN-mediated the increased expression of oncogenic p21(ras) and p53 proteins in liver tissues of rats.	Curcumin	36-39	KRAS proto-oncogene, GTPase	Rattus norvegicus	110-113
10972672-8	2000	Pretreatment with MAP kinase kinase inhibitor PD098059 or JNK-c-Jun/AP-1 inhibitor curcumin attenuated the H2O2-induced apoptosis.	Curcumin	83-91	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	62-67
10972672-8	2000	Pretreatment with MAP kinase kinase inhibitor PD098059 or JNK-c-Jun/AP-1 inhibitor curcumin attenuated the H2O2-induced apoptosis.	Curcumin	83-91	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	68-72
10925121-14	2000	Treatment with curcumin increased HO-1 expression fourfold (P &lt;0.05).	Curcumin	15-23	heme oxygenase 1	Rattus norvegicus	34-38
10783313-9	2000	CAPE and curcumin also decreased expression of the oncoprotein beta-catenin in the enterocytes of the Min/+ mouse, an observation previously associated with an antitumor effect.	Curcumin	9-17	catenin (cadherin associated protein), beta 1	Mus musculus	63-75
10954053-5	2000	When the effect of the nuclear factor-KB inhibitor pyrrolidine dithiocarbamate (PDTC) and activating protein-1 inhibitor curcumin were examined, a dose-dependent inhibition of cytokine-activated NGF expression occurred in the presence of PDTC or curcumin.	Curcumin	121-129	nerve growth factor	Mus musculus	195-198
10954053-5	2000	When the effect of the nuclear factor-KB inhibitor pyrrolidine dithiocarbamate (PDTC) and activating protein-1 inhibitor curcumin were examined, a dose-dependent inhibition of cytokine-activated NGF expression occurred in the presence of PDTC or curcumin.	Curcumin	246-254	nerve growth factor	Mus musculus	195-198
10454518-5	1999	The capacity of etoposide to promote double-stranded DNA degradation and cell death was unaffected by manipulations that interfere with SAPK signaling outflow through c-Jun/AP1, including: 1) pharmacological inhibition of AP1 activity by diferuloylmethane and 2) molecular ablation of normal c-Jun function by the Jun dominant-negative mutant TAM-67.	Curcumin	238-255	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	222-225
12938514-6	1999	The 5-BrdU incorporation rate and the distribution of DNA content indicated that curcumin could arrest cells in the G1/G0 and G2/M phase of cell cycle.	Curcumin	81-89	proline rich protein BstNI subfamily 3	Homo sapiens	116-128
9488042-6	1998	Both curcumin (1,7-bis[4-hydroxy-3-methoxy-phenyl]-1,6-heptadiene-3,5-dione), an inhibitor of the biosynthesis of AP-1, and the expression of dominant negative c-Jun inhibited the activation of AP-1 and the induction of apoptosis by bufalin.	Curcumin	5-13	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	160-165
8890196-7	1996	Furthermore, P-LPS-induced expression of the MCP-1 gene in the cells also was blocked by inhibitors of two transcription factors, i.e., curcumin, an inhibitor of AP-1, and pyrolidine dithiocarbamate, an inhibitor of NF-kappaB.	Curcumin	136-144	chemokine (C-C motif) ligand 2	Mus musculus	45-50
8887459-2	1996	Pretreatment with isosafrole, safrole, dihydrosafrole, and benzodioxole at dosages as low as 10 mg/kg significantly prevented the increase in plasma transaminase levels and histochemical changes associated with CCl4-induced liver necrosis, whereas piperonyl butoxide (PBO), eugenol, isoeugenol, sesamol, and curcumin did not prevent CCl4 hepatotoxicity even at 200 mg/kg.	Curcumin	308-316	chemokine (C-C motif) ligand 4	Mus musculus	211-215
8928842-6	1996	Stable transfection with a c-jun antisense cDNA or pretreatment with curcumin, a pharmacological inhibitor of c-Jun/AP-1, revealed that inactivation of AP-1 diminished the induction of stromelysin by PDTC.	Curcumin	69-77	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	110-115
8928842-6	1996	Stable transfection with a c-jun antisense cDNA or pretreatment with curcumin, a pharmacological inhibitor of c-Jun/AP-1, revealed that inactivation of AP-1 diminished the induction of stromelysin by PDTC.	Curcumin	69-77	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-120
8928842-6	1996	Stable transfection with a c-jun antisense cDNA or pretreatment with curcumin, a pharmacological inhibitor of c-Jun/AP-1, revealed that inactivation of AP-1 diminished the induction of stromelysin by PDTC.	Curcumin	69-77	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	152-156
8597030-3	1996	Oral administration of spice principles, curcumin from turmeric (30 mg/kg body weight) or eugenol from cloves (100 mg/kg body weight), for 10 days lowered the liver and serum lipid peroxide levels, serum ALAT, ASAT and LDH, enhanced by i.p.	Curcumin	41-49	glutamic--pyruvic transaminase	Rattus norvegicus	204-208
8534267-1	1996	The effect of curcumin on lysosomal hydrolases in serum and heart was studied by determining the activities of beta-glucuronidase, beta-N-acetylglucosaminidase, cathepsin B, cathepsin D, and acid phosphatase.	Curcumin	14-22	glucuronidase, beta	Rattus norvegicus	111-129
8993955-0	1996	Enhancing effect of ultraviolet A on ornithine decarboxylase induction and dermatitis evoked by 12-o-tetradecanoylphorbol-13-acetate and its inhibition by curcumin in mouse skin.	Curcumin	155-163	ornithine decarboxylase, structural 1	Mus musculus	37-60
7586157-2	1995	In the present study topical application of commercial grade curcumin, pure curcumin or demethoxycurcumin had an equally potent inhibitory effect on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in ornithine decarboxylase activity and TPA-induced tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated mouse skin.	Curcumin	61-69	ornithine decarboxylase, structural 1	Mus musculus	213-236
8435870-7	1993	The results indicate that curcumin inhibits TPA-induced increases in epidermal ODC enzyme activity by inhibiting the synthesis and/or enhancing the breakdown of ODC mRNA.	Curcumin	26-34	ornithine decarboxylase, structural 1	Mus musculus	79-82
8435870-7	1993	The results indicate that curcumin inhibits TPA-induced increases in epidermal ODC enzyme activity by inhibiting the synthesis and/or enhancing the breakdown of ODC mRNA.	Curcumin	26-34	ornithine decarboxylase, structural 1	Mus musculus	161-164
33806914-5	2021	The obtained results revealed that curcumin, 6-gingerol, capsaicin, and resveratrol represent potential PDE4D inhibitors; however, the predicted binding free energies of 6-gingerol, capsaicin, and resveratrol were less negative than in the case of curcumin, which exhibited the highest inhibitory potency in comparison with a positive control rolipram.	Curcumin	35-43	phosphodiesterase 4D	Homo sapiens	104-109
33806914-9	2021	The uncovered molecular inhibitory mechanisms of four investigated natural polyphenols, curcumin, 6-gingerol, capsaicin, and resveratrol, form the basis for the design of novel PDE4D inhibitors for the treatment of Alzheimer"s disease with a potentially wider therapeutic window and fewer adverse side effects.	Curcumin	88-96	phosphodiesterase 4D	Homo sapiens	177-182
33237490-8	2021	Curcumin and BA + curcumin combination showed an enhancement in synaptophysin levels of Abeta1-42-induced synaptosomes (P < 0.01).	Curcumin	18-26	synaptophysin	Rattus norvegicus	64-77
33233251-6	2020	The bioactivity analysis revealed that CSP-NPs system could effectively deliver PAC and Cur to exhibit strong antioxidant activity, potent neuroprotective effect against Abeta1-42-mediated toxicity in PC-12 cells (recovered cell viability from 57.5% to 81.0% at the dose of 25 mug/mL) and effective antiproliferative effects on HepG2 and Hela cells.	Curcumin	88-91	DnaJ heat shock protein family (Hsp40) member C5	Rattus norvegicus	39-42
34896432-0	2022	Curcumin alleviates arsenic-induced injury in duck skeletal muscle via regulating the PINK1/Parkin pathway and protecting mitochondrial function.	Curcumin	0-8	PTEN induced kinase 1	Homo sapiens	86-91
34896432-8	2022	Our further investigation found that ATO disrupted normal mitochondrial fission/fusion (Drp1, OPA1, Mfn1/2) and restrained mitochondrial biogenesis (PGC-1alpha, Nrf1/2, TFAM), while curcumin could promote mitochondrial fusion and activated PGC-1alpha pathway.	Curcumin	182-190	mitofusin 1	Homo sapiens	100-106
34896432-9	2022	Furthermore, curcumin was found that it could not only reduce the mRNA and protein levels of mitophagy (PINK1, Parkin, LC3, p62) and pro-apoptotic genes (p53, Bax, Caspase-3, Cytc), but also increased the levels of anti-apoptotic genes (Bcl-2).	Curcumin	13-21	PTEN induced kinase 1	Homo sapiens	104-109
34896432-9	2022	Furthermore, curcumin was found that it could not only reduce the mRNA and protein levels of mitophagy (PINK1, Parkin, LC3, p62) and pro-apoptotic genes (p53, Bax, Caspase-3, Cytc), but also increased the levels of anti-apoptotic genes (Bcl-2).	Curcumin	13-21	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	119-122
34896432-9	2022	Furthermore, curcumin was found that it could not only reduce the mRNA and protein levels of mitophagy (PINK1, Parkin, LC3, p62) and pro-apoptotic genes (p53, Bax, Caspase-3, Cytc), but also increased the levels of anti-apoptotic genes (Bcl-2).	Curcumin	13-21	nucleoporin 62	Homo sapiens	124-127
34950248-0	2021	Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1alpha/FNDC5/BDNF Pathway.	Curcumin	0-8	brain-derived neurotrophic factor	Rattus norvegicus	114-118
34957997-6	2021	Furthermore, curcumin treatment suppressed the expression of DNA methylation-related enzymes, including DNMT1, DNMT3A, and DNMT3B, in NSCLC cells.	Curcumin	13-21	DNA methyltransferase 1	Homo sapiens	104-109
34409523-0	2021	Therapeutic Potential of Curcumin in Reversing the Depression and Associated Pseudodementia via Modulating Stress Hormone, Hippocampal Neurotransmitters, and BDNF Levels in Rats.	Curcumin	25-33	brain-derived neurotrophic factor	Rattus norvegicus	158-162
34751624-0	2021	Curcumin mediates repulsive guidance molecule B (RGMb) in the treatment mechanism of renal fibrosis induced by unilateral ureteral obstruction.	Curcumin	0-8	repulsive guidance molecule BMP co-receptor b	Rattus norvegicus	18-47
34751624-0	2021	Curcumin mediates repulsive guidance molecule B (RGMb) in the treatment mechanism of renal fibrosis induced by unilateral ureteral obstruction.	Curcumin	0-8	repulsive guidance molecule BMP co-receptor b	Rattus norvegicus	49-53
34751624-1	2021	In this study, we explored the role and mechanism of repulsive guidance molecule B (RGMb, also known as Dragon) in the protective effects of curcumin against renal fibrosis and verified Dragon"s effect on renal tubular epithelial cell apoptosis and cell programmability.	Curcumin	141-149	repulsive guidance molecule BMP co-receptor b	Rattus norvegicus	53-82
34751624-1	2021	In this study, we explored the role and mechanism of repulsive guidance molecule B (RGMb, also known as Dragon) in the protective effects of curcumin against renal fibrosis and verified Dragon"s effect on renal tubular epithelial cell apoptosis and cell programmability.	Curcumin	141-149	repulsive guidance molecule BMP co-receptor b	Rattus norvegicus	84-88
34751624-5	2021	Curcumin significantly downregulated the TGF-beta1, P-Smad2/3, cleaved caspase-3, cleaved caspase-8 and Dragon levels.	Curcumin	0-8	caspase 8	Rattus norvegicus	90-99
34828017-6	2021	The expression levels of apoptotic genes or proteins in either pro-apoptosis (CASP3 and FAS) or anti-apoptosis (BCL2, BCL2L1, and CFLAR) were significantly manipulated by the effects of either quercetin or curcumin.	Curcumin	206-214	CASP8 and FADD like apoptosis regulator	Bos taurus	130-135
34487706-0	2021	LncRNA H19 abrogates the protective effects of curcumin on rat carotid balloon injury via activating Wnt/beta-catenin signaling pathway.	Curcumin	47-55	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	7-10
34487706-6	2021	Furthermore, the inhibition of the expression of H19 by curcumin resulted in the inactivation of the Wnt/beta-catenin signaling.	Curcumin	56-64	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	49-52
34487706-7	2021	Overall, we show that curcumin suppresses intimal hyperplasia via the H19/Wnt/beta-catenin pathway, implying that H19 is a critical molecule in the suppression of intimal hyperplasia after balloon injury by curcumin.	Curcumin	22-30	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	70-73
34487706-7	2021	Overall, we show that curcumin suppresses intimal hyperplasia via the H19/Wnt/beta-catenin pathway, implying that H19 is a critical molecule in the suppression of intimal hyperplasia after balloon injury by curcumin.	Curcumin	22-30	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	114-117
34487706-7	2021	Overall, we show that curcumin suppresses intimal hyperplasia via the H19/Wnt/beta-catenin pathway, implying that H19 is a critical molecule in the suppression of intimal hyperplasia after balloon injury by curcumin.	Curcumin	207-215	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	70-73
34487706-7	2021	Overall, we show that curcumin suppresses intimal hyperplasia via the H19/Wnt/beta-catenin pathway, implying that H19 is a critical molecule in the suppression of intimal hyperplasia after balloon injury by curcumin.	Curcumin	207-215	H19, imprinted maternally expressed transcript (non-protein coding)	Rattus norvegicus	114-117
34272803-5	2021	What"s more, curcumin exerted influences on the activities of myeloperoxidase and on the secretion of inflammatory cytokines in liver and kidney tissues.	Curcumin	13-21	myeloperoxidase	Mus musculus	62-77
34510720-5	2021	Curcumin supplementation significantly reduced adiposity and total macrophage infiltration in WAT, compared to HFD group, consistent with reduced mRNA levels of M1 (Cd80, Cd38, Cd11c) and M2 (Arginase-1) macrophage markers.	Curcumin	0-8	CD38 antigen	Mus musculus	171-175
34510720-6	2021	Moreover, curcumin supplementation reduced expression of other key pro-inflammatory genes, such as NF-kappaB p65 subunit (p65), Stat1, Tlr4, and Il6, in WAT (p<0.05).	Curcumin	10-18	signal transducer and activator of transcription 1	Mus musculus	128-133
34802538-0	2021	The ameliorative effect of curcumin on hepatic CYP1A1 and CYP1A2 genes dysregulation and hepatorenal damage induced by fenitrothion oral intoxication in male rats.	Curcumin	27-35	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	58-64
34541720-7	2021	Serum levels of IFN-gamma (p = .52) and IL-17 (p = .11) decreased, while IL-4 (p = .12) and TGF-beta (p = .14) increased in the nano-curcumin group compared with placebo on day 14.	Curcumin	133-141	interleukin 17A	Homo sapiens	40-45
34638706-3	2021	In this paper, we present new curcumin derivatives featuring a 4-piperidone ring as PTP1B inhibitors and ROS inducers.	Curcumin	30-38	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	84-89
34638706-8	2021	Finally, computational analysis was performed for the curcumin derivatives with an inhibitory effect against PTP1B phosphatase to assess the potential binding mode of new inhibitors within the allosteric site of the enzyme.	Curcumin	54-62	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	109-114
34198046-0	2021	Comparative protein profiling reveals the inhibitory role of curcumin on IL-17A mediated minichromosome maintenance (MCM) proteins as novel putative markers for acute lung injury in vivo.	Curcumin	61-69	interleukin 17A	Mus musculus	73-79
34198046-7	2021	Several trends were identified from the proteomic subset which revealed that IL-17A induces expressions of proteins like MCM2, MCM3, and MCM6 along with other proteins involved in DR. Interestingly, curcumin was found in suppressing the expression levels of these proteins.	Curcumin	199-207	interleukin 17A	Mus musculus	77-83
34198046-10	2021	Apart from this, the present study also reports the unique contribution of curcumin in suppressing the mRNA levels of other MCMs like MCM4, MCM5, and MCM7 as well as of ORC1 and ORC2.	Curcumin	75-83	minichromosome maintenance complex component 4	Mus musculus	134-138
34462629-4	2021	Importantly, the results of qPCR and immunochemistry showed that curcumin decreased M1 (iNOS, CCL2, and CD86) but increased M2 macrophage (Arg1, CD163, and CD206) marker expression in the myocardium of MI mice during the first 7 days post-MI.	Curcumin	65-73	chemokine (C-C motif) ligand 2	Mus musculus	94-98
34462629-4	2021	Importantly, the results of qPCR and immunochemistry showed that curcumin decreased M1 (iNOS, CCL2, and CD86) but increased M2 macrophage (Arg1, CD163, and CD206) marker expression in the myocardium of MI mice during the first 7 days post-MI.	Curcumin	65-73	mannose receptor, C type 1	Mus musculus	156-161
34194553-7	2021	Curcumin significantly inhibited cell viability, migration and invasion and downregulated MMP-2, MMP-9 and EMT marker expression.	Curcumin	0-8	matrix metallopeptidase 9	Homo sapiens	97-102
34194553-8	2021	Additionally, curcumin decreased STAT3 expression by upregulating miR-301a-3p expression, and the inhibition of miR-301a-3p and the overexpression of STAT3 reversed the effects of curcumin on cell viability, migration and invasion, and MMP-2, MMP-9 and EMT marker expression in TPC-1 cells.	Curcumin	14-22	matrix metallopeptidase 9	Homo sapiens	243-248
34169637-2	2021	Here, we found that curcumin not only inhibited the growth of xenografts in chronically stressed nude mice, but also decreased the expression of matrix metalloproteinase (MMP)-2/9 and CD147 in tumour tissues.	Curcumin	20-28	matrix metallopeptidase 2	Mus musculus	145-179
34169637-2	2021	Here, we found that curcumin not only inhibited the growth of xenografts in chronically stressed nude mice, but also decreased the expression of matrix metalloproteinase (MMP)-2/9 and CD147 in tumour tissues.	Curcumin	20-28	basigin	Mus musculus	184-189
34169637-6	2021	Curcumin could also inhibit the expression of cyclin D1/CDK4/6 and anti-apoptotic protein Bcl-2/Bcl-XL induced by NE, and induced cell cycle changes and increased apoptosis.	Curcumin	0-8	cyclin D1	Mus musculus	46-55
34096956-9	2021	Curcumin altered bile acid (BA) metabolism with increased fractions of circulating deoxycholic acid (DCA) and lithocholic acid (LCA), which are the two most potent ligands for TGR5.	Curcumin	0-8	G protein-coupled bile acid receptor 1	Mus musculus	176-180
34096956-10	2021	Consistently, the enhanced effect of curcumin on Ucp1-dependent thermogenesis was eliminated by TGR5 knockout.	Curcumin	37-45	G protein-coupled bile acid receptor 1	Mus musculus	96-100
34096956-11	2021	Curcumin requires the GM and TGR5 to activate the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling pathway in thermogenic adipose tissue.	Curcumin	0-8	G protein-coupled bile acid receptor 1	Mus musculus	29-33
34231234-0	2022	Diminished CCl4 -induced hepatocellular carcinoma, oxidative stress, and apoptosis by co-administration of curcumin or selenium in mice.	Curcumin	107-115	chemokine (C-C motif) ligand 4	Mus musculus	11-15
34231234-9	2022	Our study addressed that curcumin or selenium may be helpful in the protection against liver damage induced by CCl4 .	Curcumin	25-33	chemokine (C-C motif) ligand 4	Mus musculus	111-115
34231234-12	2022	Exposure to CCl4 was found to induce significant hepatotoxicity, characterized by fibrosis, bile duct proliferation, cirrhosis, and reduced hepatic function The work was prepared to investigate the protecting capacity of curcumin, selenium alone, and in combination against HCC induced by CCl4 in the experimental animal model.	Curcumin	221-229	chemokine (C-C motif) ligand 4	Mus musculus	12-16
34229599-21	2021	U0126 (an ERK inhibitor), curcumin (an AP-1 inhibitor) or c-Jun siRNA downregulated hypoxia-induced Pref-1 expression.	Curcumin	26-34	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-43
34204873-0	2021	Anti-Metastatic and Anti-Angiogenic Effects of Curcumin Analog DK1 on Human Osteosarcoma Cells In Vitro.	Curcumin	47-55	immunoglobulin heavy diversity 5-12	Homo sapiens	63-66
34204873-15	2021	These results suggest that curcumin analog DK1 may serve as a potential new anti-osteosarcoma agent due to its anti-metastatic and anti-angiogenic attributes.	Curcumin	27-35	immunoglobulin heavy diversity 5-12	Homo sapiens	43-46
34141179-0	2021	Curcumin nicotinate suppresses abdominal aortic aneurysm pyroptosis via lncRNA PVT1/miR-26a/KLF4 axis through regulating the PI3K/AKT signaling pathway.	Curcumin	0-8	Pvt1 oncogene	Mus musculus	79-83
34981469-9	2021	The expression levels of all tested genes were altered in all treatment groups compared to the control, with that of WNT1, CTNNB1, TCF, MTOR, AKT1, BIRC5, and CCND1 showing the most robust changes in the combined curcumin/berberine/5-FU treatment.	Curcumin	213-221	baculoviral IAP repeat containing 5	Homo sapiens	148-153
35526734-0	2022	Curcumin can improve Parkinson"s disease via activating BDNF/PI3k/Akt signaling pathways.	Curcumin	0-8	brain derived neurotrophic factor	Homo sapiens	56-60
35526734-4	2022	Currently, relevant studies have confirmed that curcumin has an optimistic impact on neuroprotection via regulating BDNF and PI3k/Akt signaling pathways in neurodegenerative disease.	Curcumin	48-56	brain derived neurotrophic factor	Homo sapiens	116-120
35526734-5	2022	Here, we summarized the relationship between BDNF and PI3k/Akt signaling pathway, the main biological functions and neuroprotective effects of curcumin via activating BDNF and PI3k/Akt signaling pathways in Parkinson"s disease.	Curcumin	143-151	brain derived neurotrophic factor	Homo sapiens	167-171
35196574-6	2022	Dietary curcumin supplementation normalized the low protein diet-induced decrease of placental weight, blood sinusoid area, and proliferating cell nuclear antigen (PCNA) protein expression levels.	Curcumin	8-16	proliferating cell nuclear antigen	Rattus norvegicus	128-162
35196574-6	2022	Dietary curcumin supplementation normalized the low protein diet-induced decrease of placental weight, blood sinusoid area, and proliferating cell nuclear antigen (PCNA) protein expression levels.	Curcumin	8-16	proliferating cell nuclear antigen	Rattus norvegicus	164-168
35504740-0	2022	Retraction notice to "Curcumin inhibits proliferation and soluble collagen synthesis of NIH/3T3 cell line by modulation of miR-29a and via ERK1/2 and beta-catenin pathways" (Mol.	Curcumin	22-30	catenin (cadherin associated protein), beta 1	Mus musculus	150-162
35526196-3	2022	We also identified curcumin as a new inhibitor of NCLX.	Curcumin	19-27	solute carrier family 8 member B1	Homo sapiens	50-54
35526196-4	2022	METHODS: We examined whether curcumin and pharmacological compounds induced the inhibition of NCLX-mediated mitochondrial calcium (mtCa2+) extrusion, the role of redox metabolism in this process.	Curcumin	29-37	solute carrier family 8 member B1	Homo sapiens	94-98
35526196-7	2022	RESULTS: In vitro, curcumin exerted strong anti-tumoral activity through its action on NCLX with mtCa2+ and reactive oxygen species overload associated with a mitochondrial membrane depolarization, leading to reduced ATP production and apoptosis.	Curcumin	19-27	solute carrier family 8 member B1	Homo sapiens	87-91
35526196-8	2022	NCLX inhibition with pharmacological and molecular approaches reproduced the effects of curcumin.	Curcumin	88-96	solute carrier family 8 member B1	Homo sapiens	0-4
35526196-11	2022	CONCLUSIONS: Our findings highlight a novel anti-tumoral mechanism of curcumin through its action on NCLX and mitochondria calcium overload that could benefit for therapeutic schedule of patients with MSI CRC.	Curcumin	70-78	solute carrier family 8 member B1	Homo sapiens	101-105
35566349-3	2022	In this study, natural curcumin was prepared for the curcumin beta-cyclodextrin inclusion complex (CUR-beta-CD), curcumin solid dispersion (CUR-PEG-6000), and curcumin phospholipid complex (CUR-HSPC) using co-precipitation, melting, and solvent methods, respectively.	Curcumin	23-31	ACD shelterin complex subunit and telomerase recruitment factor	Canis lupus familiaris	103-110
35566349-7	2022	This confirmed that CUR-beta-CD, CUR-HSPC, and especially CUR-PEG-6000 could effectively improve the bioavailability of curcumin.	Curcumin	120-128	ACD shelterin complex subunit and telomerase recruitment factor	Canis lupus familiaris	24-31
35367881-8	2022	Nevertheless, curcumin increased the H3K27 acetylation level at the manganese superoxide dismutase (SOD2) gene promoter and promoted the expression of SOD2 gene.	Curcumin	14-22	superoxide dismutase 2	Rattus norvegicus	68-98
35367881-8	2022	Nevertheless, curcumin increased the H3K27 acetylation level at the manganese superoxide dismutase (SOD2) gene promoter and promoted the expression of SOD2 gene.	Curcumin	14-22	superoxide dismutase 2	Rattus norvegicus	100-104
35367881-8	2022	Nevertheless, curcumin increased the H3K27 acetylation level at the manganese superoxide dismutase (SOD2) gene promoter and promoted the expression of SOD2 gene.	Curcumin	14-22	superoxide dismutase 2	Rattus norvegicus	151-155
35367881-11	2022	In addition, curcumin ameliorates Mn-induced neurotoxicity may be due to alleviation of oxidative damage mediated by increased activation of H3K27 acetylation at the SOD2 gene promoter.	Curcumin	13-21	superoxide dismutase 2	Rattus norvegicus	166-170
35015114-7	2022	In retinal ischemia reperfusion injury, curcumin downregulates IL-17, IL-23, NFKB, STAT-3, MCP-1 and JNK.	Curcumin	40-48	interleukin 17A	Homo sapiens	63-68
35571134-0	2022	Curcumin Restrains Oxidative Stress of After Intracerebral Hemorrhage in Rat by Activating the Nrf2/HO-1 Pathway.	Curcumin	0-8	heme oxygenase 1	Rattus norvegicus	100-104
35571134-9	2022	The results showed that curcumin significantly inhibited heme-induced oxidative stress, decreased intracellular ROS and MDA, and promoted Nrf2 and its downstream antioxidant gene (HO-1, NQO1, and Gpx4) expression.	Curcumin	24-32	heme oxygenase 1	Rattus norvegicus	180-184
35571134-10	2022	These results suggest that curcumin inhibits oxidative stress by activating the Nrf2/HO-1 pathway.	Curcumin	27-35	heme oxygenase 1	Rattus norvegicus	85-89
35571134-11	2022	Here, our results indicate that curcumin can promote the inhibition of oxidative stress in microglia by activating the Nrf2/HO-1 pathway and promoting neurological recovery after ICH, providing a new therapeutic target for clinical treatment of ICH.	Curcumin	32-40	heme oxygenase 1	Rattus norvegicus	124-128
35563141-9	2022	Even at a low bioavailable concentration, genistein and curcumin decreased MOLT-4 viability, and their combination had a significant interactive effect.	Curcumin	56-64	transmembrane protein 132D	Homo sapiens	75-79
35563141-10	2022	While resveratrol and quercetin did not affect MOLT-4 viability, together they enhanced the effect of the genistein/curcumin mix, significantly inhibiting MOLT-4 population growth in vitro.	Curcumin	116-124	transmembrane protein 132D	Homo sapiens	155-159
35458704-6	2022	When AhR was knocked down, LPS-induced IL-6 and TNF-alpha were increased and curcumin-decreased activation of the inflammation mediator NF-kappaB p65 by LPS was abolished.	Curcumin	77-85	aryl hydrocarbon receptor	Rattus norvegicus	5-8
35076853-13	2022	As expected, ROS scavenger NAC reversed the inhibitory effect on growth and DNA repair pathway activity mediated by curcumin.	Curcumin	116-124	X-linked Kx blood group	Homo sapiens	27-30
35399832-7	2022	Results: With curcumin concentration increasing, the expressions of MMP2, MMP9, MTOR, and p-MTOR proteins and the number of cells in the S phase decreased gradually, while number of cells in G1 and G2/M phases and cells apoptosis rate increased continuously.	Curcumin	14-22	matrix metallopeptidase 9	Homo sapiens	74-78
35063475-10	2022	In addition, curcumin significantly reduced the characteristic indices of AFB1-induced pyroptosis, such as the expression of mRNAs for genes related to NOD-like receptor protein 3 (NLRP3) inflammasome assembly and activation, the expression of key proteins (NLRP3, Caspase-1 and GSDMD).	Curcumin	13-21	gasdermin D	Mus musculus	279-284
35063475-12	2022	Notably, administration of curcumin upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its related downstream antioxidant molecules (SOD, CAT, HO-1, NQO1) and phase II detoxification enzyme-related molecules (GST, GSH, GSS, GCLC, GCLM) in the presence of AFB1 exposure.	Curcumin	27-35	NAD(P)H dehydrogenase, quinone 1	Mus musculus	183-187
35063475-12	2022	Notably, administration of curcumin upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its related downstream antioxidant molecules (SOD, CAT, HO-1, NQO1) and phase II detoxification enzyme-related molecules (GST, GSH, GSS, GCLC, GCLM) in the presence of AFB1 exposure.	Curcumin	27-35	glutamate-cysteine ligase, catalytic subunit	Mus musculus	258-262
35268671-0	2022	Curcumin-Injected Musca domestica Larval Hemolymph: Cecropin Upregulation and Potential Anticancer Effect.	Curcumin	0-8	cecropin-A2	Musca domestica	52-60
35268671-13	2022	The upregulation of cecropin expression at mRNA and protein levels may be attributed to the curcumin stimulation and linked to the increased cytotoxicity toward the cancer cell line.	Curcumin	92-100	cecropin-A2	Musca domestica	20-28
35120520-11	2022	The docking scores toward proteins 3ODU of CXCR4 and 6K3F of CXCR7 were - 7.71 and - 7.17 for curcumin, - 5.97 and - 6.03 for quercetin, - 5.68 and - 5.49 for trans-resveratrol, and - 4.88 and - 4.70 for (1 s,4 s)-eucalyptol respectively indicating that all compounds, except quercetin, have more interactions with CXCR4 than with CXCR7.	Curcumin	94-102	C-X-C motif chemokine receptor 4	Homo sapiens	43-48
35120520-11	2022	The docking scores toward proteins 3ODU of CXCR4 and 6K3F of CXCR7 were - 7.71 and - 7.17 for curcumin, - 5.97 and - 6.03 for quercetin, - 5.68 and - 5.49 for trans-resveratrol, and - 4.88 and - 4.70 for (1 s,4 s)-eucalyptol respectively indicating that all compounds, except quercetin, have more interactions with CXCR4 than with CXCR7.	Curcumin	94-102	atypical chemokine receptor 3	Homo sapiens	61-66
35055300-0	2022	Curcumin and Silver Doping Enhance the Spinnability and Antibacterial Activity of Melt-Electrospun Polybutylene Succinate Fibers.	Curcumin	0-8	ventricular zone expressed PH domain containing 1	Homo sapiens	82-86
35055300-7	2022	This is the first report describing the effect of curcumin and silver nanoparticles on the properties of PBS fibers manufactured using a single-nozzle melt-electrospinning device.	Curcumin	50-58	ventricular zone expressed PH domain containing 1	Homo sapiens	151-155
35097276-9	2022	The results enforce the notion that a global allosteric network exists in the dengue NS2B-NS3 protease, which is susceptible to allosteric inhibition by small molecules such as myricetin and curcumin.	Curcumin	191-199	KRAS proto-oncogene, GTPase	Homo sapiens	90-93