PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 17849177-1 2008 PURPOSE: Eritoran (E5564) is a glycophospholipid that acts as a toll-like receptor 4 (TLR4) antagonist that is being tested as a treatment for severe sepsis and septic shock. glycophospholipid 31-48 toll-like receptor 4 Oryctolagus cuniculus 64-84 17849177-1 2008 PURPOSE: Eritoran (E5564) is a glycophospholipid that acts as a toll-like receptor 4 (TLR4) antagonist that is being tested as a treatment for severe sepsis and septic shock. glycophospholipid 31-48 toll-like receptor 4 Oryctolagus cuniculus 86-90 17090619-1 2007 Linker for activation of B cell (LAB)/non-T cell activation linker (NTAL) and phosphoprotein associated with glycophospholipid-enriched membrane microdomain (PAG)/Csk-binding protein (Cbp) are raft-associated transmembrane adaptor proteins with distinct functions in immediate/early phases of receptor signaling pathways. glycophospholipid 109-126 linker for activation of T cells family member 2 Homo sapiens 68-72 16987101-7 2007 Notwithstanding, IPCs incorporated into glycosylphosphatidylinositol anchors of 4Delta.Lass5 show normal mobility on TLC and the ceramide- and raft-dependent traffic of Gas1p (glycophospholipid-anchored surface protein) from endoplasmic reticulum to Golgi remains almost normal. glycophospholipid 176-193 ceramide synthase 5 Mus musculus 87-92 16987101-7 2007 Notwithstanding, IPCs incorporated into glycosylphosphatidylinositol anchors of 4Delta.Lass5 show normal mobility on TLC and the ceramide- and raft-dependent traffic of Gas1p (glycophospholipid-anchored surface protein) from endoplasmic reticulum to Golgi remains almost normal. glycophospholipid 176-193 1,3-beta-glucanosyltransferase GAS1 Saccharomyces cerevisiae S288C 169-174 17090619-1 2007 Linker for activation of B cell (LAB)/non-T cell activation linker (NTAL) and phosphoprotein associated with glycophospholipid-enriched membrane microdomain (PAG)/Csk-binding protein (Cbp) are raft-associated transmembrane adaptor proteins with distinct functions in immediate/early phases of receptor signaling pathways. glycophospholipid 109-126 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 Homo sapiens 163-182 17090619-1 2007 Linker for activation of B cell (LAB)/non-T cell activation linker (NTAL) and phosphoprotein associated with glycophospholipid-enriched membrane microdomain (PAG)/Csk-binding protein (Cbp) are raft-associated transmembrane adaptor proteins with distinct functions in immediate/early phases of receptor signaling pathways. glycophospholipid 109-126 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 Homo sapiens 184-187 9242611-4 1997 The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. glycophospholipid 74-91 TNF receptor superfamily member 10c Homo sapiens 24-40 11350953-5 2001 DcR1 is devoid of an intracellular domain and is anchored at the cell surface membrane by a glycophospholipid. glycophospholipid 92-109 TNF receptor superfamily member 10c Homo sapiens 0-4 9639537-0 1998 GPI anchor biosynthesis in yeast: phosphoethanolamine is attached to the alpha1,4-linked mannose of the complete precursor glycophospholipid. glycophospholipid 123-140 glucose-6-phosphate isomerase Homo sapiens 0-3 9242611-4 1997 The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. glycophospholipid 74-91 TNF receptor superfamily member 10c Homo sapiens 42-46 8845756-1 1996 A soluble, monomeric form of acetylcholinesterase from mouse (mAChE), truncated at its carboxyl-terminal end, was generated from a cDNA encoding the glycophospholipid-linked form of the mouse enzyme by insertion of an early stop codon at position 549. glycophospholipid 149-166 acetylcholinesterase Mus musculus 29-49 9090058-5 1997 ORF O2145 shows 41.2% identity with the glycophospholipid-anchored surface glycoprotein Gas1p of S. cerevisiae and ORF O2197 has 53.2% identity to chromosome segregation protein Dis3p of Schizosaccharomyces pombe. glycophospholipid 40-57 1,3-beta-glucanosyltransferase GAS1 Saccharomyces cerevisiae S288C 88-93 9090058-5 1997 ORF O2145 shows 41.2% identity with the glycophospholipid-anchored surface glycoprotein Gas1p of S. cerevisiae and ORF O2197 has 53.2% identity to chromosome segregation protein Dis3p of Schizosaccharomyces pombe. glycophospholipid 40-57 exosome catalytic subunit DIS3 Saccharomyces cerevisiae S288C 178-183 8845756-1 1996 A soluble, monomeric form of acetylcholinesterase from mouse (mAChE), truncated at its carboxyl-terminal end, was generated from a cDNA encoding the glycophospholipid-linked form of the mouse enzyme by insertion of an early stop codon at position 549. glycophospholipid 149-166 acetylcholinesterase Mus musculus 62-67 7690370-4 1993 The phosphatidylinositol-specific enzyme, PIPLC, cleaved DAF from the surface of D54-MG cells, demonstrating that DAF is linked by a glycophospholipid anchor as has been shown for other cell types. glycophospholipid 133-150 protein disulfide isomerase family A member 3 Homo sapiens 42-47 7690370-4 1993 The phosphatidylinositol-specific enzyme, PIPLC, cleaved DAF from the surface of D54-MG cells, demonstrating that DAF is linked by a glycophospholipid anchor as has been shown for other cell types. glycophospholipid 133-150 CD55 molecule (Cromer blood group) Homo sapiens 114-117 7688303-5 1993 No cross-reaction was detected with the following antigens: salt-soluble (SS) AChE from bovine brain, glycophospholipid-anchored AChE from human and bovine erythrocytes, DS-butyrylcholinesterase and SS-butyrylcholinesterase (BtChE) from the brains of human and bovine, DS-BtChE from chicken and BtChE from human serum. glycophospholipid 102-119 acetylcholinesterase Bos taurus 129-133 7686772-0 1993 Cholesterol regulates the cell surface expression of glycophospholipid-anchored CD14 antigen on human monocytes. glycophospholipid 53-70 CD14 molecule Homo sapiens 80-84 8449945-5 1993 However, splicing of exon 4 to exon 5, yielding a mRNA encoding the glycophospholipid-linked form of acetylcholinesterase, is seen primarily in erythroid and to a lesser extent in AtT-20 cells. glycophospholipid 68-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 1346244-0 1992 A cDNA construct of tissue inhibitor of metalloproteinases (TIMP) linked to the last exon of Thy-1 confers glycophospholipid anchorage on this naturally secreted protein. glycophospholipid 107-124 tissue inhibitor of metalloproteinase 1 Mus musculus 20-58 7687365-10 1993 Moreover, MOG appears to represent a novel member of this superfamily in that it possesses two potential transmembrane domains, in contrast to a single membrane-spanning domain or glycophospholipid anchor found in all other members of this superfamily. glycophospholipid 180-197 myelin oligodendrocyte glycoprotein Gallus gallus 10-13 1532143-0 1992 Endocytosis of glycophospholipid-anchored and transmembrane forms of CD4 by different endocytic pathways. glycophospholipid 15-32 T-cell surface glycoprotein CD4 Cricetulus griseus 69-72 1346244-0 1992 A cDNA construct of tissue inhibitor of metalloproteinases (TIMP) linked to the last exon of Thy-1 confers glycophospholipid anchorage on this naturally secreted protein. glycophospholipid 107-124 tissue inhibitor of metalloproteinase 1 Mus musculus 60-64 1346244-0 1992 A cDNA construct of tissue inhibitor of metalloproteinases (TIMP) linked to the last exon of Thy-1 confers glycophospholipid anchorage on this naturally secreted protein. glycophospholipid 107-124 thymus cell antigen 1, theta Mus musculus 93-98 1346244-6 1992 It is concluded that the last exon of Thy-1 has conferred the property of glycophospholipid anchorage on the normally secreted protein TIMP. glycophospholipid 74-91 thymus cell antigen 1, theta Mus musculus 38-43 1346244-6 1992 It is concluded that the last exon of Thy-1 has conferred the property of glycophospholipid anchorage on the normally secreted protein TIMP. glycophospholipid 74-91 tissue inhibitor of metalloproteinase 1 Mus musculus 135-139 1824714-0 1991 Determinants for glycophospholipid anchoring of the Saccharomyces cerevisiae GAS1 protein to the plasma membrane. glycophospholipid 17-34 1,3-beta-glucanosyltransferase GAS1 Saccharomyces cerevisiae S288C 77-81 1682315-0 1991 Characterization of glycophospholipid intermediate in the biosynthesis of glycophosphatidylinositol anchors accumulating in the Thy-1-negative lymphoma line SIA-b. glycophospholipid 20-37 Thy-1 cell surface antigen Homo sapiens 128-133 1674734-0 1991 Activation of T lymphocytes by cross-linking of glycophospholipid-anchored Thy-1 mobilizes separate pools of intracellular second messengers to those induced by the antigen-receptor/CD3 complex. glycophospholipid 48-65 Thy-1 cell surface antigen Homo sapiens 75-80 1961202-0 1991 Biosynthesis of glycophospholipid bound and secreted murine class I Qa-2 polypeptides. glycophospholipid 16-33 Qa lymphocyte antigen 2 region Mus musculus 68-72 1709701-0 1991 Human immunodeficiency virus infection and syncytium formation in HeLa cells expressing glycophospholipid-anchored CD4. glycophospholipid 88-105 CD4 molecule Homo sapiens 115-118 1709701-5 1991 This resulted in the anchoring of the extracellular domain of CD4 to the cell membrane via a glycophospholipid linkage. glycophospholipid 93-110 CD4 molecule Homo sapiens 62-65 1709701-6 1991 The glycophospholipid-anchored CD4 had a molecular size of approximately 56 to 62 kDa and was released following treatment of the cells with phosphatidylinositol-specific phospholipase C. HeLa cells expressing the CD4-DAF hybrid could be infected with HIV-1, as evidenced by reverse transcriptase activity, p24 core antigen content, and infectious virus production. glycophospholipid 4-21 CD4 molecule Homo sapiens 31-34 1709701-6 1991 The glycophospholipid-anchored CD4 had a molecular size of approximately 56 to 62 kDa and was released following treatment of the cells with phosphatidylinositol-specific phospholipase C. HeLa cells expressing the CD4-DAF hybrid could be infected with HIV-1, as evidenced by reverse transcriptase activity, p24 core antigen content, and infectious virus production. glycophospholipid 4-21 CD4 molecule Homo sapiens 214-217 1709701-6 1991 The glycophospholipid-anchored CD4 had a molecular size of approximately 56 to 62 kDa and was released following treatment of the cells with phosphatidylinositol-specific phospholipase C. HeLa cells expressing the CD4-DAF hybrid could be infected with HIV-1, as evidenced by reverse transcriptase activity, p24 core antigen content, and infectious virus production. glycophospholipid 4-21 CD55 molecule (Cromer blood group) Homo sapiens 218-221 1824714-7 1991 We conclude that glycophospholipid anchoring of Gas1p depends on the integrity of the C-terminal hydrophobic domain that is removed during anchor attachment. glycophospholipid 17-34 1,3-beta-glucanosyltransferase GAS1 Saccharomyces cerevisiae S288C 48-53 1697596-0 1990 Complete and partial glycophospholipid anchors are found on a fusion protein consisting of luteinizing hormone beta subunit followed by a carboxyl-terminal domain of Thy-1. glycophospholipid 21-38 lutropin subunit beta Bos taurus 91-123 1983274-1 1990 Thy-1 is a major glycophospholipid (GPL)-anchored protein found on the surface of neurons, epithelial cells, fibroblasts and murine T-lymphomas. glycophospholipid 17-34 thymus cell antigen 1, theta Mus musculus 0-5 1697596-0 1990 Complete and partial glycophospholipid anchors are found on a fusion protein consisting of luteinizing hormone beta subunit followed by a carboxyl-terminal domain of Thy-1. glycophospholipid 21-38 thymus cell antigen 1, theta Mus musculus 166-171 1697596-1 1990 The Thy-1 antigen is anchored to the cell surface by a carboxyl-terminal glycophospholipid moiety. glycophospholipid 73-90 thymus cell antigen 1, theta Mus musculus 4-17 2129526-10 1990 Thus, it is concluded that the mature 5"-nucleotidase lacks the predicted COOH-terminal peptide extension (524-548), which has been replaced by the glycophospholipid functioning as the membrane anchor of 5"-nucleotidase. glycophospholipid 148-165 5'-nucleotidase ecto Homo sapiens 38-53 2129526-10 1990 Thus, it is concluded that the mature 5"-nucleotidase lacks the predicted COOH-terminal peptide extension (524-548), which has been replaced by the glycophospholipid functioning as the membrane anchor of 5"-nucleotidase. glycophospholipid 148-165 5'-nucleotidase ecto Homo sapiens 204-219 1688584-10 1990 The nature of the signal that directs posttranslational attachment of a glycophospholipid anchor to DAF is not known, but that signal is apparently spread over three exons and greater than 20 kb. glycophospholipid 72-89 CD55 molecule (Cromer blood group) Homo sapiens 100-103 33815382-4 2021 The TLR4/MD-2 complex can recognize the terminal motif of Gram-negative bacterial lipopolysaccharide (LPS)-a glycophospholipid lipid A. glycophospholipid 109-126 toll like receptor 4 Homo sapiens 4-8 33815382-4 2021 The TLR4/MD-2 complex can recognize the terminal motif of Gram-negative bacterial lipopolysaccharide (LPS)-a glycophospholipid lipid A. glycophospholipid 109-126 lymphocyte antigen 96 Homo sapiens 9-13 2904699-1 1988 Many plasma membrane proteins, including Thy-1, are anchored by a carboxyl terminal glycophospholipid. glycophospholipid 84-101 Thy-1 cell surface antigen Homo sapiens 41-46 2477368-1 1989 Decay accelerating factor (DAF) is a glycophospholipid-anchored membrane glycoprotein that protects mammalian host cells from inadvertant complement lysis. glycophospholipid 37-54 CD55 molecule (Cromer blood group) Homo sapiens 0-25 2477368-1 1989 Decay accelerating factor (DAF) is a glycophospholipid-anchored membrane glycoprotein that protects mammalian host cells from inadvertant complement lysis. glycophospholipid 37-54 CD55 molecule (Cromer blood group) Homo sapiens 27-30 2466338-1 1989 Decay accelerating factor (DAF) is anchored to the plasma membrane by a glycophospholipid (GPI) membrane anchor covalently attached to the COOH-terminus of the protein. glycophospholipid 72-89 CD55 molecule (Cromer blood group) Homo sapiens 0-25 2466338-1 1989 Decay accelerating factor (DAF) is anchored to the plasma membrane by a glycophospholipid (GPI) membrane anchor covalently attached to the COOH-terminus of the protein. glycophospholipid 72-89 CD55 molecule (Cromer blood group) Homo sapiens 27-30 2530453-0 1989 A glycophospholipid anchor is required for Qa-2-mediated T cell activation. glycophospholipid 2-19 Qa lymphocyte antigen 2 region Mus musculus 43-47 2831298-6 1988 We conclude that AChE from insect brain is attached to membranes via a glycophospholipid anchor. glycophospholipid 71-88 Acetylcholine esterase Drosophila melanogaster 17-21 2842340-8 1988 Taken together, these results suggest that CEA is anchored to the membrane by simultaneously occurring proteolysis of the carboxyl terminus and replacement by the glycophospholipid immediately after the synthesis. glycophospholipid 163-180 CEA cell adhesion molecule 3 Homo sapiens 43-46 2451546-3 1988 DAF, AChE, and LAP are known to be anchored within cell membranes to glycophospholipid-containing phosphatidylinositol (PI). glycophospholipid 69-86 CD55 molecule (Cromer blood group) Homo sapiens 0-3 2451546-3 1988 DAF, AChE, and LAP are known to be anchored within cell membranes to glycophospholipid-containing phosphatidylinositol (PI). glycophospholipid 69-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 3203325-3 1988 3H-Labeled precursors of glycophospholipid such as ethanolamine and stearic acid were incorporated into CEA produced by both normal and cancerous tissues, suggesting that CEA in normal mucosa is anchored to the cell membrane through a glycophospholipid as in cancerous tissues. glycophospholipid 25-42 CEA cell adhesion molecule 3 Homo sapiens 104-107 3203325-3 1988 3H-Labeled precursors of glycophospholipid such as ethanolamine and stearic acid were incorporated into CEA produced by both normal and cancerous tissues, suggesting that CEA in normal mucosa is anchored to the cell membrane through a glycophospholipid as in cancerous tissues. glycophospholipid 25-42 CEA cell adhesion molecule 3 Homo sapiens 171-174 3203325-3 1988 3H-Labeled precursors of glycophospholipid such as ethanolamine and stearic acid were incorporated into CEA produced by both normal and cancerous tissues, suggesting that CEA in normal mucosa is anchored to the cell membrane through a glycophospholipid as in cancerous tissues. glycophospholipid 235-252 CEA cell adhesion molecule 3 Homo sapiens 104-107 3203325-3 1988 3H-Labeled precursors of glycophospholipid such as ethanolamine and stearic acid were incorporated into CEA produced by both normal and cancerous tissues, suggesting that CEA in normal mucosa is anchored to the cell membrane through a glycophospholipid as in cancerous tissues. glycophospholipid 235-252 CEA cell adhesion molecule 3 Homo sapiens 171-174 2874887-1 1986 To investigate the mechanism of glycophospholipid anchoring of the surface antigen Thy-1, we have undertaken a comparative biosynthetic study using a wild-type Thy-1+ murine T lymphoma (BW5147) and a mutant T lymphoma (class E) that synthesizes Thy-1 but fails to express it on the plasma membrane. glycophospholipid 32-49 thymus cell antigen 1, theta Mus musculus 83-88 3277539-0 1988 The insulinomimetic effects of the polar head group of an insulin-sensitive glycophospholipid on pyruvate dehydrogenase in both subcellular and whole cell assays. glycophospholipid 76-93 insulin Homo sapiens 4-11 3277539-0 1988 The insulinomimetic effects of the polar head group of an insulin-sensitive glycophospholipid on pyruvate dehydrogenase in both subcellular and whole cell assays. glycophospholipid 76-93 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 97-119 3277539-1 1988 The polar head group that was released by treating an insulin-sensitive glycophospholipid with a phosphatidylinositol-specific phospholipase C (PI-PLC) stimulated pyruvate dehydrogenase (PDH) in both subcellular and whole cell assays. glycophospholipid 72-89 insulin Homo sapiens 54-61 3277539-1 1988 The polar head group that was released by treating an insulin-sensitive glycophospholipid with a phosphatidylinositol-specific phospholipase C (PI-PLC) stimulated pyruvate dehydrogenase (PDH) in both subcellular and whole cell assays. glycophospholipid 72-89 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 163-185 3277539-1 1988 The polar head group that was released by treating an insulin-sensitive glycophospholipid with a phosphatidylinositol-specific phospholipase C (PI-PLC) stimulated pyruvate dehydrogenase (PDH) in both subcellular and whole cell assays. glycophospholipid 72-89 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 187-190 3277539-10 1988 These data support the proposal that an early step in insulin action is the release of insulinomimetic polar head group from the insulin-sensitive glycophospholipid. glycophospholipid 147-164 insulin Homo sapiens 54-61 3277539-10 1988 These data support the proposal that an early step in insulin action is the release of insulinomimetic polar head group from the insulin-sensitive glycophospholipid. glycophospholipid 147-164 insulin Homo sapiens 87-94 2891709-1 1988 Defective glycophospholipid anchoring, rapid degradation, and secretion of Thy-1 glycoprotein. glycophospholipid 10-27 Thy-1 cell surface antigen Homo sapiens 75-80 2891709-2 1988 Thy-1 glycoprotein is a member of a class of proteins which are anchored to the plasma membrane via a covalently bound glycophospholipid. glycophospholipid 119-136 Thy-1 cell surface antigen Homo sapiens 0-5 2891709-19 1988 These observations are discussed with reference to the possibility that the lesions which characterize the mutants pertain to the biosynthesis of the glycophospholipid moiety of Thy-1. glycophospholipid 150-167 Thy-1 cell surface antigen Homo sapiens 178-183 2446389-1 1987 Decay accelerating factor (DAF) belongs to a novel group of membrane proteins anchored to the cell surface by a glycophospholipid membrane anchor that is covalently attached to the carboxyl terminus of the protein. glycophospholipid 112-129 CD55 molecule (Cromer blood group) Homo sapiens 0-25 2446389-1 1987 Decay accelerating factor (DAF) belongs to a novel group of membrane proteins anchored to the cell surface by a glycophospholipid membrane anchor that is covalently attached to the carboxyl terminus of the protein. glycophospholipid 112-129 CD55 molecule (Cromer blood group) Homo sapiens 27-30 2446389-2 1987 The last 37 amino acids of membrane DAF, when fused to the carboxyl terminus of a secreted protein, are sufficient to target the fusion protein to the plasma membrane by means of a glycophospholipid anchor. glycophospholipid 181-198 CD55 molecule (Cromer blood group) Homo sapiens 36-39 2881925-0 1987 The glycophospholipid anchor of Thy-1. glycophospholipid 4-21 Thy-1 cell surface antigen Homo sapiens 32-37 2881925-2 1987 The Thy-1 antigen of the surface of lymphocytes and neurons is anchored to the plasma membrane via a glycophospholipid moiety. glycophospholipid 101-118 Thy-1 cell surface antigen Homo sapiens 4-17 2888493-5 1987 In addition, the Thy-1 glycoprotein has the particularity of being anchored to the membrane via a glycophospholipid tail. glycophospholipid 98-115 thymus cell antigen 1, theta Mus musculus 17-22 2422055-4 1986 From these results we conclude that the glycophospholipid anchors of protozoan VSG and of AChE of the two vertebrates share common structural features, suggesting that this novel type of membrane anchor has been conserved during evolution. glycophospholipid 40-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 2869796-0 1985 A glycophospholipid covalently attached to the C-terminus of the Thy-1 glycoprotein. glycophospholipid 2-19 Thy-1 cell surface antigen Rattus norvegicus 65-83 2865810-0 1985 A glycophospholipid tail at the carboxyl terminus of the Thy-1 glycoprotein of neurons and thymocytes. glycophospholipid 2-19 Thy-1 cell surface antigen Homo sapiens 57-62 26329338-6 2015 RESULTS: The metabolic pathways for carnitine, tryptophan, phenylalanine, arachidonic acid, and glycophospholipid were significantly upregulated in OA SF. glycophospholipid 96-113 OAP Homo sapiens 148-153 21512604-3 2011 Synthetic PIM/LM/LAM substructures are useful biochemical tools to delineate and dissect the fine details of mannose glycophospholipid biosynthesis and their interactions with host cells. glycophospholipid 117-134 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 10-13 23952219-2 2013 A pro-inflammatory signaling cascade is initiated upon binding of membrane-associated portion of LPS, a glycophospholipid Lipid A, by a coreceptor protein MD-2, which results in a protective host innate immune response. glycophospholipid 104-121 toll-like receptor 4 Mus musculus 97-100 23952219-2 2013 A pro-inflammatory signaling cascade is initiated upon binding of membrane-associated portion of LPS, a glycophospholipid Lipid A, by a coreceptor protein MD-2, which results in a protective host innate immune response. glycophospholipid 104-121 lymphocyte antigen 96 Mus musculus 155-159