PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24150655-4	2013	While investigating the action of either TNF-alpha or Tag7-Hsp70 on L-929 cells we detected two peaks of death: after 3 h and after 20 h. For both cytotoxic agents we observed the first, smaller (13-15%), peak to be eliminated after the addition of caspase inhibitor YVAD-CHO and the second, greater (25-30%), peak to become even bigger in presence of caspase inhibitor.	tyrosyl-valyl-alanyl-aspartal	267-275	heat shock protein 1B	Mus musculus	59-64
12918059-4	2003	IFN-gamma produced in prostate cancers induced caspase-1 mRNA and IL-18 secretion of tumor cell lines, which was inhibited by the cell-permeable Tyr-Val-Ala-Asp-aldehyde caspase-1 inhibitor (YVAD-CHO).	tyrosyl-valyl-alanyl-aspartal	145-169	interferon gamma	Homo sapiens	0-9
12918059-4	2003	IFN-gamma produced in prostate cancers induced caspase-1 mRNA and IL-18 secretion of tumor cell lines, which was inhibited by the cell-permeable Tyr-Val-Ala-Asp-aldehyde caspase-1 inhibitor (YVAD-CHO).	tyrosyl-valyl-alanyl-aspartal	145-169	caspase 1	Homo sapiens	47-56
12918059-4	2003	IFN-gamma produced in prostate cancers induced caspase-1 mRNA and IL-18 secretion of tumor cell lines, which was inhibited by the cell-permeable Tyr-Val-Ala-Asp-aldehyde caspase-1 inhibitor (YVAD-CHO).	tyrosyl-valyl-alanyl-aspartal	145-169	interleukin 18	Homo sapiens	66-71
12918059-4	2003	IFN-gamma produced in prostate cancers induced caspase-1 mRNA and IL-18 secretion of tumor cell lines, which was inhibited by the cell-permeable Tyr-Val-Ala-Asp-aldehyde caspase-1 inhibitor (YVAD-CHO).	tyrosyl-valyl-alanyl-aspartal	145-169	caspase 1	Homo sapiens	170-179
12918059-4	2003	IFN-gamma produced in prostate cancers induced caspase-1 mRNA and IL-18 secretion of tumor cell lines, which was inhibited by the cell-permeable Tyr-Val-Ala-Asp-aldehyde caspase-1 inhibitor (YVAD-CHO).	tyrosyl-valyl-alanyl-aspartal	191-199	interferon gamma	Homo sapiens	0-9
12918059-4	2003	IFN-gamma produced in prostate cancers induced caspase-1 mRNA and IL-18 secretion of tumor cell lines, which was inhibited by the cell-permeable Tyr-Val-Ala-Asp-aldehyde caspase-1 inhibitor (YVAD-CHO).	tyrosyl-valyl-alanyl-aspartal	191-199	caspase 1	Homo sapiens	47-56
12918059-4	2003	IFN-gamma produced in prostate cancers induced caspase-1 mRNA and IL-18 secretion of tumor cell lines, which was inhibited by the cell-permeable Tyr-Val-Ala-Asp-aldehyde caspase-1 inhibitor (YVAD-CHO).	tyrosyl-valyl-alanyl-aspartal	191-199	interleukin 18	Homo sapiens	66-71
12918059-4	2003	IFN-gamma produced in prostate cancers induced caspase-1 mRNA and IL-18 secretion of tumor cell lines, which was inhibited by the cell-permeable Tyr-Val-Ala-Asp-aldehyde caspase-1 inhibitor (YVAD-CHO).	tyrosyl-valyl-alanyl-aspartal	191-199	caspase 1	Homo sapiens	170-179
12529972-4	2002	Treatment with the general caspase inhibitor Z-VAD-fmk, as well as the caspase-1 inhibitor YVAD-CHO, significantly blocked beta 2m-induced apoptosis.	tyrosyl-valyl-alanyl-aspartal	91-99	caspase 1	Homo sapiens	71-80
12529972-4	2002	Treatment with the general caspase inhibitor Z-VAD-fmk, as well as the caspase-1 inhibitor YVAD-CHO, significantly blocked beta 2m-induced apoptosis.	tyrosyl-valyl-alanyl-aspartal	91-99	beta-2-microglobulin	Homo sapiens	123-130
11556886-5	2001	Blockade of the IL-1beta-converting enzyme (ICE) by Tyr-Val-Ala-Asp-aldehyde (YVAD-CHO) decreased the levels of mature IL-1beta but had no effect on pro-IL-1beta.	tyrosyl-valyl-alanyl-aspartal	52-76	caspase 1	Rattus norvegicus	16-42
11556886-5	2001	Blockade of the IL-1beta-converting enzyme (ICE) by Tyr-Val-Ala-Asp-aldehyde (YVAD-CHO) decreased the levels of mature IL-1beta but had no effect on pro-IL-1beta.	tyrosyl-valyl-alanyl-aspartal	52-76	caspase 1	Rattus norvegicus	44-47
11556886-5	2001	Blockade of the IL-1beta-converting enzyme (ICE) by Tyr-Val-Ala-Asp-aldehyde (YVAD-CHO) decreased the levels of mature IL-1beta but had no effect on pro-IL-1beta.	tyrosyl-valyl-alanyl-aspartal	52-76	interleukin 1 beta	Rattus norvegicus	16-24
11556886-5	2001	Blockade of the IL-1beta-converting enzyme (ICE) by Tyr-Val-Ala-Asp-aldehyde (YVAD-CHO) decreased the levels of mature IL-1beta but had no effect on pro-IL-1beta.	tyrosyl-valyl-alanyl-aspartal	52-76	interleukin 1 beta	Rattus norvegicus	119-127
11556886-5	2001	Blockade of the IL-1beta-converting enzyme (ICE) by Tyr-Val-Ala-Asp-aldehyde (YVAD-CHO) decreased the levels of mature IL-1beta but had no effect on pro-IL-1beta.	tyrosyl-valyl-alanyl-aspartal	78-86	caspase 1	Rattus norvegicus	16-42
11556886-5	2001	Blockade of the IL-1beta-converting enzyme (ICE) by Tyr-Val-Ala-Asp-aldehyde (YVAD-CHO) decreased the levels of mature IL-1beta but had no effect on pro-IL-1beta.	tyrosyl-valyl-alanyl-aspartal	78-86	caspase 1	Rattus norvegicus	44-47
11556886-5	2001	Blockade of the IL-1beta-converting enzyme (ICE) by Tyr-Val-Ala-Asp-aldehyde (YVAD-CHO) decreased the levels of mature IL-1beta but had no effect on pro-IL-1beta.	tyrosyl-valyl-alanyl-aspartal	78-86	interleukin 1 beta	Rattus norvegicus	16-24
11556886-5	2001	Blockade of the IL-1beta-converting enzyme (ICE) by Tyr-Val-Ala-Asp-aldehyde (YVAD-CHO) decreased the levels of mature IL-1beta but had no effect on pro-IL-1beta.	tyrosyl-valyl-alanyl-aspartal	78-86	interleukin 1 beta	Rattus norvegicus	119-127
11516428-9	2001	Inhibitor for caspase-1-like activity, YVAD-CHO, neither reduced the fractin staining nor showed comparable neuroprotective effects to the retina.	tyrosyl-valyl-alanyl-aspartal	39-47	caspase 1	Rattus norvegicus	14-23
11399517-11	2001	Furthermore, treatment with the IL-1 beta converting enzyme (ICE) specific reversible inhibitor YVAD-CHO resulted in a sharp dose- and time-dependent inhibition of IL-1 beta secretion in the serum, whereas the other cytokines were not affected.	tyrosyl-valyl-alanyl-aspartal	96-104	caspase 1	Mus musculus	32-59
11399517-11	2001	Furthermore, treatment with the IL-1 beta converting enzyme (ICE) specific reversible inhibitor YVAD-CHO resulted in a sharp dose- and time-dependent inhibition of IL-1 beta secretion in the serum, whereas the other cytokines were not affected.	tyrosyl-valyl-alanyl-aspartal	96-104	caspase 1	Mus musculus	61-64
11399517-11	2001	Furthermore, treatment with the IL-1 beta converting enzyme (ICE) specific reversible inhibitor YVAD-CHO resulted in a sharp dose- and time-dependent inhibition of IL-1 beta secretion in the serum, whereas the other cytokines were not affected.	tyrosyl-valyl-alanyl-aspartal	96-104	interleukin 1 beta	Mus musculus	32-41
10496353-5	1999	An ICE inhibitor, Acetyl-Tyr-Val-Ala-Asp-CHO (YVAD-CHO) blocked IL-1beta-induced growth inhibition in KU-1 and KU-2.	tyrosyl-valyl-alanyl-aspartal	46-54	caspase 1	Homo sapiens	3-6
10496353-5	1999	An ICE inhibitor, Acetyl-Tyr-Val-Ala-Asp-CHO (YVAD-CHO) blocked IL-1beta-induced growth inhibition in KU-1 and KU-2.	tyrosyl-valyl-alanyl-aspartal	46-54	interleukin 1 beta	Homo sapiens	64-72
10470105-7	1999	Simultaneously, TNF alpha stimulated induction of iNOS and generation of NO.. Caspase inhibitors DEVD-CHO, YVAD-cmk and YVAD-CHO effectively inhibited caspase activation and prevented apoptosis.	tyrosyl-valyl-alanyl-aspartal	120-128	tumor necrosis factor	Homo sapiens	16-25
10470105-7	1999	Simultaneously, TNF alpha stimulated induction of iNOS and generation of NO.. Caspase inhibitors DEVD-CHO, YVAD-cmk and YVAD-CHO effectively inhibited caspase activation and prevented apoptosis.	tyrosyl-valyl-alanyl-aspartal	120-128	nitric oxide synthase 2	Homo sapiens	50-54
9874570-6	1999	Pretreatment with peptide caspase inhibitors zVAD-FMK or YVAD-CHO prevented GraB apoptosis and cytochrome c release, whereas DEVD-CHO blocked apoptosis but did not prevent cytochrome c release, indicating that caspases act both up- and downstream of mitochondria.	tyrosyl-valyl-alanyl-aspartal	57-65	granzyme B	Homo sapiens	76-80
9874570-6	1999	Pretreatment with peptide caspase inhibitors zVAD-FMK or YVAD-CHO prevented GraB apoptosis and cytochrome c release, whereas DEVD-CHO blocked apoptosis but did not prevent cytochrome c release, indicating that caspases act both up- and downstream of mitochondria.	tyrosyl-valyl-alanyl-aspartal	57-65	cytochrome c, somatic	Homo sapiens	95-107
9616229-5	1998	The data indicate that alterations in expression of CD3-zeta and CD3-epsilon chains in T cells coincubated with OvCA are related to tumor-induced apoptosis, as the addition of pan-caspase inhibitors, DEVD-cho or YVAD-cho, prevents both the in vitro induction of T cell death by OvCA cells and the changes in the level of expression of CD3-zeta and CD3-epsilon chains.	tyrosyl-valyl-alanyl-aspartal	212-220	CD247 molecule	Homo sapiens	52-60
9616229-5	1998	The data indicate that alterations in expression of CD3-zeta and CD3-epsilon chains in T cells coincubated with OvCA are related to tumor-induced apoptosis, as the addition of pan-caspase inhibitors, DEVD-cho or YVAD-cho, prevents both the in vitro induction of T cell death by OvCA cells and the changes in the level of expression of CD3-zeta and CD3-epsilon chains.	tyrosyl-valyl-alanyl-aspartal	212-220	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	65-76
9551718-6	1998	When cells were pretreated with the synthesized tetrapeptide inhibitor of caspase, YVAD-CHO (Ac-Tyr-Val-Ala-Asp-aldehyde: inhibitor of interleukin-1beta converting enzyme (ICE) subfamily) or DEVD-CHO (Ac-Asp-Glu-Val-Asp-aldehyde: inhibitor of CPP32 subfamily), taxotere-induced cell death was prevented.	tyrosyl-valyl-alanyl-aspartal	83-91	caspase 1	Mus musculus	172-175
9551718-6	1998	When cells were pretreated with the synthesized tetrapeptide inhibitor of caspase, YVAD-CHO (Ac-Tyr-Val-Ala-Asp-aldehyde: inhibitor of interleukin-1beta converting enzyme (ICE) subfamily) or DEVD-CHO (Ac-Asp-Glu-Val-Asp-aldehyde: inhibitor of CPP32 subfamily), taxotere-induced cell death was prevented.	tyrosyl-valyl-alanyl-aspartal	83-91	caspase 3	Mus musculus	243-248
9409756-4	1997	The caspase-1 inhibitor (YVAD-CHO) effectively blocked apoptosis, whereas the caspase-3 inhibitor (DEVD-CHO) did not.	tyrosyl-valyl-alanyl-aspartal	25-33	caspase 1	Homo sapiens	4-13
9184074-6	1997	ICE-like proteinase activity was prevented by fumonisin B1 and YVAD-CHO, but not by DEVD-CHO.	tyrosyl-valyl-alanyl-aspartal	63-71	caspase 1	Mus musculus	0-3
9184074-7	1997	In contrast, fumonisin B1, YVAD-CHO, and DEVD-CHO all prevented CPP32-like proteinase activity.	tyrosyl-valyl-alanyl-aspartal	27-35	caspase 3	Mus musculus	64-69
9116238-3	1996	In order to determine whether these proteases are involved in axotomy-induced cell death in vivo, we applied a peptide inhibitor of ICE, YVAD-CHO, to the lesioned facial nerve of 2-day-old mice.	tyrosyl-valyl-alanyl-aspartal	137-145	caspase 1	Mus musculus	132-135
8554575-3	1995	This ACA was inhibited by inhibitors of interleukin-1 beta-converting enzyme (ICE)/ced-3 family proteases, such as Z-Asp-CH2-DCB, YVAD-CHO, TPCK, TLCK, and iodoacetamide.	tyrosyl-valyl-alanyl-aspartal	130-138	caspase 1	Homo sapiens	40-76