PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8963944-4	1996	The major N-alkyl PP, N-griseofulvin PP, which is devoid of ferrochelatase-inhibitory activity, was shown to be the precursor of N-methyl PP, which is a potent ferrochelatase inhibitor.	N-methylprotoporphyrin IX	129-140	ferrochelatase	Gallus gallus	160-174
32716567-7	2020	An intravitreal injection of the FECH inhibitor N-methyl protoporphyrin had similar effects.	N-methylprotoporphyrin IX	48-71	ferrochelatase	Mus musculus	33-37
8308010-9	1994	Specifically, the recombinant ferrochelatase has iron and porphyrin as substrates, and N-methylprotoporphyrin and metal ions (e.g. Hg2+ and Mn2+), as strong inhibitors of its enzyme activity.	N-methylprotoporphyrin IX	87-109	ferrochelatase	Homo sapiens	30-44
2283668-1	1990	A hepatic green pigment, inhibitory toward ferrochelatase, has been isolated from the liver of mice treated with griseofulvin, isogriseofulvin, or 3,5-diethoxycarbonyl-1,4-dihydrocollidine and has been shown to exhibit identical chromatographic characteristics to authentic N-methyl protoporphyrin.	N-methylprotoporphyrin IX	274-297	ferrochelatase	Mus musculus	43-57
3477226-4	1987	N-Methylprotoporphyrin at nanomolar concentrations also strongly inhibited ferrochelatase activity, but had no inhibitory effect on cellular haem production.	N-methylprotoporphyrin IX	0-22	ferrochelatase	Mus musculus	75-89
6896292-0	1982	Inhibition of ferrochelatase by N-methylprotoporphyrin IX is not accompanied by delta-aminolevulinic acid synthetase induction in chick embryo liver cell culture.	N-methylprotoporphyrin IX	32-57	ferrochelatase	Gallus gallus	14-28
6896292-1	1982	N-Methylprotoporphyrin has been shown to markedly inhibit ferrochelatase activity in chick embryo liver cell culture without inducing delta-aminolevulinic acid (ALA) synthetase activity.	N-methylprotoporphyrin IX	0-22	ferrochelatase	Gallus gallus	58-72
32912968-4	2020	Herein we find that treating primary hepatocytes with MDB-inducing agents (N-methylprotoporphyrin (NMPP), protoporphyrin IX (PPIX), or Zinc-protoporphyrin IX (ZnPP)) elicited an IkBa-loss with consequent NF-kB activation.	N-methylprotoporphyrin IX	75-97	NFKB inhibitor alpha	Homo sapiens	178-182
8494497-6	1993	The ATMP pigment markedly inhibited the enzyme ferrochelatase in vitro, thus supporting its identification as N-methyl protoporphyrin.	N-methylprotoporphyrin IX	110-133	ferrochelatase	Mus musculus	47-61
1764043-7	1991	These findings suggest that cytochrome P-450 is involved in the mechanism of griseofulvin-induced protoporphyria by generating N-methylprotoporphyrin.	N-methylprotoporphyrin IX	127-149	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	28-44
16668110-11	1991	The potent ferrochelatase inhibitors, N-methylmesoporphyrin and N-methylprotoporphyrin, inhibited Mg-chelatase at micromolar concentrations.	N-methylprotoporphyrin IX	64-86	ferrochelatase-2, chloroplastic-like	Cucumis sativus	11-25
2012610-2	1991	A hepatic green pigment with inhibitory properties towards the enzyme ferrochelatase has been isolated from the liver of mice treated with griseofulvin and identified as N-methylprotoporphyrin.	N-methylprotoporphyrin IX	170-192	ferrochelatase	Mus musculus	70-84
2804139-4	1989	The data obtained demonstrate that mouse ferrochelatase binds a wide variety of porphyrins and metalloporphyrins with kd values ranging from 6 nM for N-methylprotoporphyrin to 1.08 microM for coproporphyrin III.	N-methylprotoporphyrin IX	150-172	ferrochelatase	Mus musculus	41-55
3218729-3	1988	That zinc chelatase and ferrochelatase activities reside in the same enzyme was shown by the competitive action of ferrous ions and the inhibitory effects of N-methyl protoporphyrin (a specific inhibitor of heme synthetase) on zinc chelatase.	N-methylprotoporphyrin IX	158-181	ferrochelatase	Homo sapiens	207-222
6390167-5	1984	DDC has been found to cause the accumulation of a green pigment, identified as N-methyl protoporphyrin IX (N-MePP), which is a potent inhibitor of ferrochelatase.	N-methylprotoporphyrin IX	79-105	ferrochelatase	Gallus gallus	147-161
6390167-5	1984	DDC has been found to cause the accumulation of a green pigment, identified as N-methyl protoporphyrin IX (N-MePP), which is a potent inhibitor of ferrochelatase.	N-methylprotoporphyrin IX	107-113	ferrochelatase	Gallus gallus	147-161
6688622-9	1983	N-Methylprotoporphyrin, a toxic by-product of the metabolism of some drugs, was found to inhibit ferrochelatase in a competitive fashion with respect to porphyrin with a Ki of 7 nM and uncompetitive with respect to iron.	N-methylprotoporphyrin IX	0-22	FECH	Bos taurus	97-111
28347842-5	2017	RESULTS: The blockade of heme biosynthesis by succinylacetone and N-methyl protoporphyrin, which are inhibitors of heme biosynthesis, markedly decreased the induction of HO-1.	N-methylprotoporphyrin IX	66-89	heme oxygenase 1	Homo sapiens	170-174
29985945-7	2018	Treatment of BCAs with NMPP initiated a time- and dose-dependent attenuation of FECH activity without changes in its protein expression, followed by significant reduction in the heme level.	N-methylprotoporphyrin IX	23-27	ferrochelatase	Homo sapiens	80-84
29985945-8	2018	Moreover, ACh-induced relaxation and ACh-stimulated release of NO were significant reduced, associated with suppression of eNOS protein expression in NMPP-treated groups.	N-methylprotoporphyrin IX	150-154	nitric oxide synthase 3	Homo sapiens	123-127
19698763-7	2009	The heme synthesis inhibitor N-methylprotoporphyrinIX (NMP) lengthened the circadian period of SCN PER2::LUC rhythms by about an hour.	N-methylprotoporphyrin IX	29-53	period circadian clock 2	Mus musculus	99-103
26343413-7	2015	N-methyl PPIX strongly inhibits ferrochelatase, the enzyme that converts PPIX to heme, and leads to PPIX accumulation.	N-methylprotoporphyrin IX	0-13	ferrochelatase	Mus musculus	32-46
25414439-8	2015	That ferrochelatase is essential to parasite growth was confirmed by showing that inhibition of ferrochelatase using the specific competitive inhibitor, N-methylprotoporphyrin, produced a potent growth inhibition effect against cultures of P falciparum.	N-methylprotoporphyrin IX	153-175	ferrochelatase	Homo sapiens	5-19
25414439-8	2015	That ferrochelatase is essential to parasite growth was confirmed by showing that inhibition of ferrochelatase using the specific competitive inhibitor, N-methylprotoporphyrin, produced a potent growth inhibition effect against cultures of P falciparum.	N-methylprotoporphyrin IX	153-175	ferrochelatase	Homo sapiens	96-110
22859313-6	2012	CYP2A5 was intensively and HMOX1 moderately elevated in heme synthesis blockades by succinylacetone and N-methyl protoporphyrin IX, and Nrf2 partially mediated the induction of CYP2A5.	N-methylprotoporphyrin IX	104-130	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	0-6
22859313-6	2012	CYP2A5 was intensively and HMOX1 moderately elevated in heme synthesis blockades by succinylacetone and N-methyl protoporphyrin IX, and Nrf2 partially mediated the induction of CYP2A5.	N-methylprotoporphyrin IX	104-130	heme oxygenase 1	Mus musculus	27-32
19698763-7	2009	The heme synthesis inhibitor N-methylprotoporphyrinIX (NMP) lengthened the circadian period of SCN PER2::LUC rhythms by about an hour.	N-methylprotoporphyrin IX	55-58	period circadian clock 2	Mus musculus	99-103
15769864-4	2005	In contrast, the rate of de novo CYP2B1/2 protein synthesis was found to be dramatically inhibited in both DDEP- and NMPP-treated hepatocytes.	N-methylprotoporphyrin IX	117-121	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	33-39
19002554-3	2009	We repressed heme synthesis in cells by inhibiting ferrochelatase enzyme with small interfering RNA and N-methylprotoporphyrin IX.	N-methylprotoporphyrin IX	104-129	ferrochelatase	Homo sapiens	51-65
16792525-0	2006	Modulation of inhibition of ferrochelatase by N-methylprotoporphyrin.	N-methylprotoporphyrin IX	46-68	ferrochelatase	Homo sapiens	28-42
16792525-2	2006	NMPP (N-methylprotoporphyrin), a transition-state analogue and potent inhibitor of ferrochelatase, is commonly used to induce haem deficiency in mammalian cell cultures.	N-methylprotoporphyrin IX	0-4	ferrochelatase	Homo sapiens	83-97
16792525-2	2006	NMPP (N-methylprotoporphyrin), a transition-state analogue and potent inhibitor of ferrochelatase, is commonly used to induce haem deficiency in mammalian cell cultures.	N-methylprotoporphyrin IX	6-28	ferrochelatase	Homo sapiens	83-97
16792525-3	2006	To create ferrochelatase variants with different extents of tolerance towards NMPP and to understand further the mechanism of ferrochelatase inhibition by NMPP, we isolated variants with increased NMPP resistance, bearing mutations in an active-site loop (murine ferrochelatase residues 248-257), which was previously shown to mediate a protein conformational change triggered by porphyrin binding.	N-methylprotoporphyrin IX	155-159	ferrochelatase	Mus musculus	126-140
16792525-3	2006	To create ferrochelatase variants with different extents of tolerance towards NMPP and to understand further the mechanism of ferrochelatase inhibition by NMPP, we isolated variants with increased NMPP resistance, bearing mutations in an active-site loop (murine ferrochelatase residues 248-257), which was previously shown to mediate a protein conformational change triggered by porphyrin binding.	N-methylprotoporphyrin IX	155-159	ferrochelatase	Mus musculus	126-140
16792525-3	2006	To create ferrochelatase variants with different extents of tolerance towards NMPP and to understand further the mechanism of ferrochelatase inhibition by NMPP, we isolated variants with increased NMPP resistance, bearing mutations in an active-site loop (murine ferrochelatase residues 248-257), which was previously shown to mediate a protein conformational change triggered by porphyrin binding.	N-methylprotoporphyrin IX	155-159	ferrochelatase	Mus musculus	126-140
16792525-3	2006	To create ferrochelatase variants with different extents of tolerance towards NMPP and to understand further the mechanism of ferrochelatase inhibition by NMPP, we isolated variants with increased NMPP resistance, bearing mutations in an active-site loop (murine ferrochelatase residues 248-257), which was previously shown to mediate a protein conformational change triggered by porphyrin binding.	N-methylprotoporphyrin IX	155-159	ferrochelatase	Mus musculus	126-140
16792525-5	2006	While the binding affinity of the P255X variants for NMPP decreased by one order of magnitude in relation to that of wild-type enzyme, the inhibition constant increased by approximately two orders of magnitude (K(i)(app) values of 1 microM and 2.3 microM for P255R and P255G respectively, as against 3 nM for wild-type ferrochelatase).	N-methylprotoporphyrin IX	53-57	ferrochelatase	Mus musculus	319-333
16792525-7	2006	Further, although NMPP binding to either wild-type ferrochelatase or P255R occurred via a similar two-step kinetic mechanism, the forward and reverse rate constants associated with the second and rate-limiting step were comparable for the two enzymes.	N-methylprotoporphyrin IX	18-22	ferrochelatase	Homo sapiens	51-65
16306232-6	2006	Inhibition of heme synthesis (by 70-80%) at different enzymic steps by succinyl acetone and N-methylprotoporphyrin IX resulted in the earlier lowered expression of NMDAzeta1 and -epsilon2 and NF-L.	N-methylprotoporphyrin IX	92-117	neurofilament, light polypeptide	Mus musculus	192-196
12417755-2	2002	Heme deficiency was induced with N-methylprotoporphyrin IX, a selective inhibitor of ferrochelatase, in two human brain cell lines, SHSY5Y (neuroblastoma) and U373 (astrocytoma), as well as in rat primary hippocampal neurons.	N-methylprotoporphyrin IX	33-58	ferrochelatase	Homo sapiens	85-99
10795314-4	2000	The activity of the ferrochelatase was inhibited by N-methylprotoporphyrin IX (I50 = 4 nM).	N-methylprotoporphyrin IX	52-77	ferrochelatase-2, chloroplastic-like	Cucumis sativus	20-34
10725301-0	2000	N-Methylprotoporphyrin is a more potent inhibitor of recombinant human than of recombinant chicken ferrochelatase.	N-methylprotoporphyrin IX	0-22	ferrochelatase	Gallus gallus	99-113
10725301-1	2000	The potency of N-methylprotoporphyrin IX (N-methylPP) as a ferrochelatase (FC) inhibitor has been previously studied using crude chick embryo liver FC preparations.	N-methylprotoporphyrin IX	15-40	ferrochelatase	Gallus gallus	59-73
10725301-1	2000	The potency of N-methylprotoporphyrin IX (N-methylPP) as a ferrochelatase (FC) inhibitor has been previously studied using crude chick embryo liver FC preparations.	N-methylprotoporphyrin IX	15-40	ferrochelatase	Gallus gallus	75-77
10725301-1	2000	The potency of N-methylprotoporphyrin IX (N-methylPP) as a ferrochelatase (FC) inhibitor has been previously studied using crude chick embryo liver FC preparations.	N-methylprotoporphyrin IX	15-40	ferrochelatase	Gallus gallus	148-150
10725301-3	2000	The first objective of this study was to compare the potency of N-methylPP as an inhibitor of purified chicken FC and crude chick embryo liver FC.	N-methylprotoporphyrin IX	64-74	ferrochelatase	Gallus gallus	111-113
10725301-3	2000	The first objective of this study was to compare the potency of N-methylPP as an inhibitor of purified chicken FC and crude chick embryo liver FC.	N-methylprotoporphyrin IX	64-74	ferrochelatase	Gallus gallus	143-145
10725301-4	2000	The EC(50) values of N-methylPP previously observed in crude chick embryo liver FC was 2.9 x 10(-3) nmol/mg protein, and with purified recombinant chicken FC was 2.07 x 10(-3) nmol/mg protein.	N-methylprotoporphyrin IX	21-31	ferrochelatase	Gallus gallus	80-82
10725301-6	2000	The second objective of this study was to compare the potency of N-methylPP between purified human and chicken FC.	N-methylprotoporphyrin IX	65-75	ferrochelatase	Gallus gallus	111-113
10725301-7	2000	The EC(50) value of N-methylPP observed in the purified human FC preparation was 1.7 x 10(-6) nmol/mg protein (chicken FC 2.07 x 10(-3) nmol/mg protein).	N-methylprotoporphyrin IX	20-30	ferrochelatase	Gallus gallus	62-64
10725301-8	2000	Thus, the potency of N-methylPP was much higher with purified human FC than with purified chicken FC.	N-methylprotoporphyrin IX	21-31	ferrochelatase	Gallus gallus	68-70
8806750-4	1996	Inhibition by N-methyl-protoporphyrin IX occurs at IC50 values of 6, 5, and 8 microM for the nNOS, iNOS, and eNOS isoforms, respectively.	N-methylprotoporphyrin IX	14-40	nitric oxide synthase 1, neuronal	Mus musculus	93-97
8806750-4	1996	Inhibition by N-methyl-protoporphyrin IX occurs at IC50 values of 6, 5, and 8 microM for the nNOS, iNOS, and eNOS isoforms, respectively.	N-methylprotoporphyrin IX	14-40	nitric oxide synthase 2, inducible	Mus musculus	99-103