PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22183159-6	2012	The platform was also used to determine the toxic impact of the alkaloid camptothecin on the intracellular enzyme glucose-6-phosphate dehydrogenase levels.	Alkaloids	64-72	glucose-6-phosphate dehydrogenase	Homo sapiens	114-147
22229634-4	2012	STR1 presently provides exclusively access to 3 and can act as a source to generate by chemoenzymatic approaches libraries of this novel class of alkaloids which may have new biological activities.	Alkaloids	146-155	matrix metallopeptidase 3	Homo sapiens	0-4
22113202-0	2012	Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.	Alkaloids	30-38	synuclein alpha	Homo sapiens	68-83
22830335-7	2012	These identified natural MDM2 inhibitors include a plethora of diverse chemical frameworks, ranging from flavonoids, steroids, and sesquiterpenes to alkaloids.	Alkaloids	149-158	MDM2 proto-oncogene	Homo sapiens	25-29
22087636-0	2012	Six alkaloids inhibit secretion of IL-1alpha, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells.	Alkaloids	4-13	interleukin 1 alpha	Homo sapiens	35-44
22087636-0	2012	Six alkaloids inhibit secretion of IL-1alpha, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells.	Alkaloids	4-13	endothelin 1	Homo sapiens	54-58
22087636-0	2012	Six alkaloids inhibit secretion of IL-1alpha, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells.	Alkaloids	4-13	selectin E	Homo sapiens	63-73
22276180-7	2012	To the best of our knowledge, this is the first report describing phenanthroindolizidines alkaloids display influence on the crucial cell signaling proteins, ERK.	Alkaloids	90-99	mitogen-activated protein kinase 1	Homo sapiens	158-161
22108682-4	2012	Alkaloid extracts were evaluated for chemical characterization, acetylcholinesterase and antioxidant activities.	Alkaloids	0-8	acetylcholinesterase	Rattus norvegicus	64-84
22108682-12	2012	RESULTS: AChE activity was inhibited in vitro by the alkaloid-enriched extracts of both Lycopodium species in a dose and time-dependent manner in rat cortex, striatum and hippocampus.	Alkaloids	53-61	acetylcholinesterase	Rattus norvegicus	9-13
23196901-8	2012	Further experiments showed that Fuzi total alkaloid enhanced the ratio of phospho-CREB/CREB (cAMP response element-binding) and BDNF (brain-derived neurotrophic factor) protein level in the frontal cortex and hippocampus in ovariectomized mice but not in normal mice.	Alkaloids	43-51	cAMP responsive element binding protein 1	Mus musculus	82-86
23196901-8	2012	Further experiments showed that Fuzi total alkaloid enhanced the ratio of phospho-CREB/CREB (cAMP response element-binding) and BDNF (brain-derived neurotrophic factor) protein level in the frontal cortex and hippocampus in ovariectomized mice but not in normal mice.	Alkaloids	43-51	cAMP responsive element binding protein 1	Mus musculus	87-91
23196901-8	2012	Further experiments showed that Fuzi total alkaloid enhanced the ratio of phospho-CREB/CREB (cAMP response element-binding) and BDNF (brain-derived neurotrophic factor) protein level in the frontal cortex and hippocampus in ovariectomized mice but not in normal mice.	Alkaloids	43-51	brain derived neurotrophic factor	Mus musculus	128-132
23196901-8	2012	Further experiments showed that Fuzi total alkaloid enhanced the ratio of phospho-CREB/CREB (cAMP response element-binding) and BDNF (brain-derived neurotrophic factor) protein level in the frontal cortex and hippocampus in ovariectomized mice but not in normal mice.	Alkaloids	43-51	brain derived neurotrophic factor	Mus musculus	134-167
23284772-10	2012	Also, SMAD-2 was phosphorylated following treatment of HaCaT cells by Catechin, Tannin and alkaloids namely Arecoline, Arecaidine and Guvacine.	Alkaloids	91-100	SMAD family member 2	Homo sapiens	6-12
23284772-11	2012	Moreover, both polyphenols and alkaloids induced TGF-beta2 and THBS1 (activator of latent TGF-beta) in HaCaT cells suggesting areca nut mediated activation of p-SMAD2 involves up-regulation and activation of TGF-beta.	Alkaloids	31-40	transforming growth factor beta 2	Homo sapiens	49-58
23284772-11	2012	Moreover, both polyphenols and alkaloids induced TGF-beta2 and THBS1 (activator of latent TGF-beta) in HaCaT cells suggesting areca nut mediated activation of p-SMAD2 involves up-regulation and activation of TGF-beta.	Alkaloids	31-40	thrombospondin 1	Homo sapiens	63-68
23284772-11	2012	Moreover, both polyphenols and alkaloids induced TGF-beta2 and THBS1 (activator of latent TGF-beta) in HaCaT cells suggesting areca nut mediated activation of p-SMAD2 involves up-regulation and activation of TGF-beta.	Alkaloids	31-40	transforming growth factor beta 1	Homo sapiens	49-57
23284772-11	2012	Moreover, both polyphenols and alkaloids induced TGF-beta2 and THBS1 (activator of latent TGF-beta) in HaCaT cells suggesting areca nut mediated activation of p-SMAD2 involves up-regulation and activation of TGF-beta.	Alkaloids	31-40	transforming growth factor beta 1	Homo sapiens	90-98
22093483-3	2012	Steroidal alkaloids having tigloyl or senecioyl group at C-3 produced diagnostic fragment ions at m/z 100 and 83.	Alkaloids	10-19	complement C3	Homo sapiens	57-60
21908684-2	2011	The recently reported fluorometric CYP2C19 progress curve analysis approach was applied first to determine whether these alkaloids demonstrate time-dependent inhibition.	Alkaloids	121-130	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	35-42
21908684-5	2011	CYP2C19 activity was not significantly restored by dialysis when it had been inactivated by the alkaloids in the presence of a NADPH-regenerating system, and a metabolic-intermediate complex-associated increase in absorbance at approximately 455 nm was observed.	Alkaloids	96-105	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
21908684-6	2011	In conclusion, the CYP2C19 progress curve analysis method revealed time-dependent inhibition by these alkaloids, and additional experiments confirmed its quasi-irreversible nature.	Alkaloids	102-111	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	19-26
21908684-8	2011	The alkaloids bulbocapnine, canadine, and protopine, present in herbal medicines, are new mechanism-based inactivators and the first MDP compounds exhibiting quasi-irreversible inactivation of CYP2C19.	Alkaloids	4-13	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	193-200
21988279-0	2011	A novel sesquiterpene acid and an alkaloid from leaves of the Eastern Nigeria mistletoe, Loranthus micranthus with potent immunostimulatory activity on C57BL6 mice splenocytes and CD69 molecule.	Alkaloids	34-42	CD69 antigen	Mus musculus	180-184
21728149-3	2011	These eleven alkaloids show in vitro anti-inflammatory activities with IC50 values ranging from 84 nM to 20.6 muM through their suppression of nitric oxide production in RAW264.7 cells stimulated by lipopolysaccharide and interferon-gamma.	Alkaloids	13-22	interferon gamma	Mus musculus	222-238
21941892-6	2011	Significant cholinesterase inhibitory activity was demonstrated by the alkaloid extract of N. undulata (IC50,(HuAChE) = 14.3 +/- 1.2 microg/mL; IC50,(HuBuChE) = 33.9 +/- 1.9 microg/mL).	Alkaloids	71-79	butyrylcholinesterase	Homo sapiens	12-26
21855623-9	2011	CONCLUSIONS: The results showed that Fructus evodiae pretreatment decreased the systemic exposure of the Rhizoma coptidis alkaloids by inducing hepatic UGT1A1.	Alkaloids	122-131	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	152-158
20349265-0	2011	The anti-invasive activity of synthetic alkaloid ethoxyfagaronine on L1210 leukemia cells is mediated by down-regulation of plasminogen activators and MT1-MMP expression and activity.	Alkaloids	40-48	matrix metallopeptidase 14 (membrane-inserted)	Mus musculus	151-158
22121808-1	2011	OBJECTIVE: To study the effects of total alkaloids of Rubus alceaefolius (RAP) on non-alcoholic fatty liver disease (NAFLD) rats and explore its possible mechanisms.	Alkaloids	41-50	LDL receptor related protein associated protein 1	Rattus norvegicus	74-77
21867914-0	2011	XPF-dependent DNA breaks and RNA polymerase II arrest induced by antitumor DNA interstrand crosslinking-mimetic alkaloids.	Alkaloids	112-121	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	0-3
21876481-0	2011	Evaluation of the effects of Mitragyna speciosa alkaloid extract on cytochrome P450 enzymes using a high throughput assay.	Alkaloids	48-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	68-83
21752383-5	2011	Under the optimum conditions, the proposed method achieved limits of detections (LOD) of between 0.2 ng mL-1 and 1.5 ng mL-1 with 1583-3556-fold increases in detection sensitivity for three analytes, which indicated that it was a promising method for analysis of alkaloids in human urine.	Alkaloids	263-272	L1 cell adhesion molecule	Mus musculus	104-114
21616062-3	2011	Among the eight alkaloids, only strychnine and icajine exhibited inhibition potency on the Na(v)1.5 channel with the half-maximum inhibition (IC(50)) values of 83.1muM and 104.6muM, respectively.	Alkaloids	16-25	immunoglobulin lambda variable 2-18	Homo sapiens	91-99
21644519-1	2011	The title compound, ent-1, the non-natural enantiomeric form of the lycorenine-type alkaloid (-)-clividine (1), has been prepared using the enantiomerically pure (ee >99.8%) cis-1,2-dihydrocatechol 3 as starting material.	Alkaloids	84-92	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	20-25
21639125-3	2011	Similar AgF-mediated intramolecular nonoxidative and oxidative palladium-catalyzed cyclizations of 8,10-dihydro-1-iodo-10-phenylphenazin-2(7H)-ones 13 gave the new "alkaloid like" ring system 8H-indolo[1,2,3-mn]phenazin-8-one 14 in 80 and 18% yields, respectively.	Alkaloids	165-173	angiopoietin like 6	Homo sapiens	8-11
21718593-2	2011	Cyclopamine (Cyc), an alkaloid from the Veratrum plant, is a specific natural product inhibitor of the Hh pathway that acts by targeting smoothened (SMO) protein.	Alkaloids	22-30	smoothened, frizzled class receptor	Homo sapiens	137-147
21574567-1	2011	Three new heteroaromatic alkaloids, nakijinamines C-E (1-3), which are a hybrid of the aaptamine-type and bromoindole alkaloids possessing a taurine- or histidine-derived residue, have been isolated from an Okinawan marine sponge Suberites species.	Alkaloids	25-34	carboxylesterase 1	Homo sapiens	50-58
21539473-6	2011	AREAS COVERED: This review comprises patents and patent applications involving POP inhibitors patented between 2003 and 2010, classified as peptidomimetics, heteroaryl ketones and alkaloids.	Alkaloids	180-189	prolyl endopeptidase	Homo sapiens	79-82
21377758-10	2011	Furthermore, the biochemical changes observed in Pds-silenced detached tomatoes suggested that carotenoid and other pathways, e.g. leading to alkaloids and flavonoids, might be affected by the silencing of this reporter gene, and this should be taken into consideration for future experimental designs.	Alkaloids	142-151	15-cis-phytoene desaturase, chloroplastic/chromoplastic	Solanum lycopersicum	49-52
21156346-7	2011	We show that both, an aqueous and an alkaloid-enriched extract specifically inhibit Wnt-signaling activity in HeLa, HCT116 and SW480 cancer cells resulting in reduced expression of the Wnt-target gene: c-Myc.	Alkaloids	37-45	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	202-207
21262330-2	2011	The ability of six alkaloids from Veratrum lobelianum, one from Veratrum nigrum and three from Peganum nigellastrum to modify transport activity of MDR1 was studied.	Alkaloids	19-28	ATP binding cassette subfamily B member 1	Homo sapiens	148-152
21418355-2	2011	Here, we functionally characterized the JA-inducible tobacco (Nicotiana tabacum) AP2/ERF factor ORC1, one of the members of the NIC2-locus ERFs that control nicotine biosynthesis and a close homologue of ORCA3, a transcriptional activator of alkaloid biosynthesis in Catharanthus roseus.	Alkaloids	242-250	ethylene-responsive transcription factor RAP2-3-like	Nicotiana tabacum	81-84
20851588-7	2011	Many of these alkaloids inhibited the CYP3A4 form, with 30/36 alkaloids inhibiting CYP3A4 with at least moderate potency (IC50 < 10 muM) and 15/36 inhibiting CYP3A4 potently (IC50 < 1 muM).	Alkaloids	62-71	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	83-89
20851588-7	2011	Many of these alkaloids inhibited the CYP3A4 form, with 30/36 alkaloids inhibiting CYP3A4 with at least moderate potency (IC50 < 10 muM) and 15/36 inhibiting CYP3A4 potently (IC50 < 1 muM).	Alkaloids	14-23	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	38-44
21494677-0	2011	Interaction of the anticancer plant alkaloid sanguinarine with bovine serum albumin.	Alkaloids	36-44	albumin	Homo sapiens	70-83
20851588-7	2011	Many of these alkaloids inhibited the CYP3A4 form, with 30/36 alkaloids inhibiting CYP3A4 with at least moderate potency (IC50 < 10 muM) and 15/36 inhibiting CYP3A4 potently (IC50 < 1 muM).	Alkaloids	62-71	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	83-89
20851588-10	2011	CYP2C19 was inhibited by 15/36 alkaloids at least moderate potently, whereas CYP1A2, CYP2B6, CYP2C8, and CYP2C9 were inhibited to a lesser degree.	Alkaloids	31-40	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
20862641-3	2011	The effects of the isolated compounds, together with twenty-one other ACONITUM alkaloids with different skeletal types and substitution patterns, on hERG channels were studied by the whole-cell patch clamp technique, using the QPatch-16 automated patch clamp system.	Alkaloids	79-88	ETS transcription factor ERG	Homo sapiens	149-153
20739156-6	2011	The results showed that among these three isolated alkaloids; stemofoline exhibited the most potent effect in vitro in the reversal of P-gp-mediated MDR.	Alkaloids	51-60	phosphoglycolate phosphatase	Homo sapiens	135-139
21217149-4	2011	In this study, we identified a plant-derived alkaloid, calystegine B(3), as a potent specific inhibitor for Man2C1 activity.	Alkaloids	45-53	mannosidase alpha class 2C member 1	Homo sapiens	108-114
21093406-5	2011	Human PNMT accepted none of the offered alkaloids and was only active with its established substrate, phenylethanolamine.	Alkaloids	40-49	phenylethanolamine N-methyltransferase	Homo sapiens	6-10
20576524-0	2011	Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency.	Alkaloids	65-73	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-31
20640477-0	2011	The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor.	Alkaloids	16-24	MAPK activated protein kinase 5	Homo sapiens	46-61
20640477-0	2011	The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor.	Alkaloids	16-24	MAPK activated protein kinase 5	Homo sapiens	63-66
20640477-0	2011	The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor.	Alkaloids	16-24	MAPK activated protein kinase 5	Homo sapiens	67-71
20640477-3	2011	We tested several diterpenoid alkaloids for their ability to suppress MK5 kinase activity.	Alkaloids	30-39	MAPK activated protein kinase 5	Homo sapiens	70-73
21372424-0	2011	Inhibitory effects of herbal alkaloids on the tumor necrosis factor-alpha and nitric oxide production in lipopolysaccharide-stimulated RAW264 macrophages.	Alkaloids	29-38	tumor necrosis factor	Mus musculus	46-73
21372424-2	2011	Since less attention has been paid to alkaloids in the diets than to polyphenols in this regard, we aimed at investigating anti-inflammatory activity of herb-derived alkaloids through suppression of TNF-alpha and NO production in lipopolysaccharide (LPS)-stimulated mouse RAW264 and/or human THP-1 cells.	Alkaloids	166-175	tumor necrosis factor	Mus musculus	199-208
21372424-10	2011	In conclusion, some herbal alkaloids like harmine, in spite of lacking antioxidative property, have potential as anti-inflammatory agents that strongly suppress TNF-alpha and NO production by a unique mechanism.	Alkaloids	27-36	tumor necrosis factor	Mus musculus	161-170
21799692-4	2011	Three alkaloids, although to differing extents, all concentration dependent, inhibited H1N1-induced RANTES production with Evo consistently being the most potent among these active components.	Alkaloids	6-15	chemokine (C-C motif) ligand 5	Mus musculus	100-106
20576524-1	2011	An antineoplastic alkaloid ellipticine is a prodrug, whose pharmacological efficiency is dependent on its cytochrome P450 (CYP)- and/or peroxidase-mediated activation in target tissues.	Alkaloids	18-26	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	106-121
20576524-1	2011	An antineoplastic alkaloid ellipticine is a prodrug, whose pharmacological efficiency is dependent on its cytochrome P450 (CYP)- and/or peroxidase-mediated activation in target tissues.	Alkaloids	18-26	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	123-126
20706796-5	2011	In the occurrence of cytotoxic effects of atisine-type alkaloids, replacement by an acyl group at both C-11 and C-15 resulted in the enhancement of activity of the parent alkaloids compared to that from having hydroxy groups at this position, and the presence of a hydroxy group at the C-6 position was required for the cytotoxic effects.	Alkaloids	55-64	aldo-keto reductase family 1 member C4	Homo sapiens	103-107
22096315-6	2011	Many alpha-glucosidase inhibitors that are phytoconstituents, such as flavonoids, alkaloids, terpenoids,anthocyanins, glycosides, phenolic compounds, and so on, have been isolated from plants.	Alkaloids	82-91	sucrase-isomaltase	Homo sapiens	5-22
20706796-5	2011	In the occurrence of cytotoxic effects of atisine-type alkaloids, replacement by an acyl group at both C-11 and C-15 resulted in the enhancement of activity of the parent alkaloids compared to that from having hydroxy groups at this position, and the presence of a hydroxy group at the C-6 position was required for the cytotoxic effects.	Alkaloids	55-64	placenta associated 8	Homo sapiens	112-116
20706796-5	2011	In the occurrence of cytotoxic effects of atisine-type alkaloids, replacement by an acyl group at both C-11 and C-15 resulted in the enhancement of activity of the parent alkaloids compared to that from having hydroxy groups at this position, and the presence of a hydroxy group at the C-6 position was required for the cytotoxic effects.	Alkaloids	171-180	aldo-keto reductase family 1 member C4	Homo sapiens	103-107
20706796-5	2011	In the occurrence of cytotoxic effects of atisine-type alkaloids, replacement by an acyl group at both C-11 and C-15 resulted in the enhancement of activity of the parent alkaloids compared to that from having hydroxy groups at this position, and the presence of a hydroxy group at the C-6 position was required for the cytotoxic effects.	Alkaloids	171-180	placenta associated 8	Homo sapiens	112-116
21151985-9	2010	The ecs mutants had higher susceptibility to ribosomal antibiotics and plant alkaloids chelerythrine and sanguinarine.	Alkaloids	77-86	epistatic circling SWR/J	Mus musculus	4-7
20449727-5	2010	Additionally, the three test alkaloids stimulate cytochrome P450 (CYP) 1 enzyme activity without showing any antagonistic effects regarding benzo(a)pyrene-stimulated CYP1 activation.	Alkaloids	29-38	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	49-72
22163834-4	2011	The modified SPR gold discs were used for exploring the Abeta(40) aggregation process in the presence of selected alkaloids: arecoline hydrobromide, pseudopelletierine hydrochloride, trigonelline hydrochloride and alpha-lobeline hydrochloride.	Alkaloids	114-123	amyloid beta precursor protein	Homo sapiens	56-61
20219658-16	2010	Moreover, some alkaloids isolated from the leaf of Alstonia scholaris exhibited inhibition of COX-1, COX-2 and 5-LOX in vitro anti-inflammatory assay, which supported alkaloids as the bioactive fraction.	Alkaloids	15-24	cytochrome c oxidase I, mitochondrial	Mus musculus	94-99
20839617-0	2010	Cytochrome P450 3A4 inhibitory activity studies within the lycorine series of alkaloids.	Alkaloids	78-87	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-19
20579892-0	2010	Tryptamine-derived alkaloids from Annonaceae exerting neurotrophin-like properties on primary dopaminergic neurons.	Alkaloids	19-28	brain derived neurotrophic factor	Homo sapiens	54-66
20737911-2	2010	Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors.	Alkaloids	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-95
20219658-16	2010	Moreover, some alkaloids isolated from the leaf of Alstonia scholaris exhibited inhibition of COX-1, COX-2 and 5-LOX in vitro anti-inflammatory assay, which supported alkaloids as the bioactive fraction.	Alkaloids	15-24	cytochrome c oxidase II, mitochondrial	Mus musculus	101-106
20219658-16	2010	Moreover, some alkaloids isolated from the leaf of Alstonia scholaris exhibited inhibition of COX-1, COX-2 and 5-LOX in vitro anti-inflammatory assay, which supported alkaloids as the bioactive fraction.	Alkaloids	15-24	lysyl oxidase	Mus musculus	113-116
20219658-18	2010	In in vitro tests, alkaloids exhibited inhibition of inflammatory mediators (COX-1, COX-2 and 5-LOX), which is accordant with results on animal models.	Alkaloids	19-28	cytochrome c oxidase I, mitochondrial	Mus musculus	77-82
20219658-18	2010	In in vitro tests, alkaloids exhibited inhibition of inflammatory mediators (COX-1, COX-2 and 5-LOX), which is accordant with results on animal models.	Alkaloids	19-28	cytochrome c oxidase II, mitochondrial	Mus musculus	84-95
20219658-18	2010	In in vitro tests, alkaloids exhibited inhibition of inflammatory mediators (COX-1, COX-2 and 5-LOX), which is accordant with results on animal models.	Alkaloids	19-28	lysyl oxidase	Mus musculus	96-99
20116429-4	2010	These alkaloids and their enantiomers were more effective in depolarizing TE-671 cells which express the human fetal-muscle type nicotinic acetylcholine receptor (nAChR) relative to SH-SY5Y cells which predominately express autonomic nAChRs.	Alkaloids	6-15	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	163-168
20196574-5	2010	This strategy will greatly facilitate future SAR studies on the natural alkaloids with E-ring variations.	Alkaloids	72-81	sarcosine dehydrogenase	Homo sapiens	45-48
20079560-0	2010	Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.	Alkaloids	71-80	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-126
20960307-8	2010	RT-PCR analysis showed that, the transcription of two important delayed early genes UL30 and UL39, and a late gene US6 of HSV-1 genome all were suppressed by the alkaloids extract, the expression inhibiting efficacy compared to the control was 74.6% (UL30), 70.9% (UL39) and 62.6% (US6) respectively at the working concentration of 12.5 mug/mL.	Alkaloids	162-171	DNA polymerase catalytic subunit	Human alphaherpesvirus 1	84-88
20960307-8	2010	RT-PCR analysis showed that, the transcription of two important delayed early genes UL30 and UL39, and a late gene US6 of HSV-1 genome all were suppressed by the alkaloids extract, the expression inhibiting efficacy compared to the control was 74.6% (UL30), 70.9% (UL39) and 62.6% (US6) respectively at the working concentration of 12.5 mug/mL.	Alkaloids	162-171	ribonucleotide reductase subunit 1	Human alphaherpesvirus 1	93-97
20960307-8	2010	RT-PCR analysis showed that, the transcription of two important delayed early genes UL30 and UL39, and a late gene US6 of HSV-1 genome all were suppressed by the alkaloids extract, the expression inhibiting efficacy compared to the control was 74.6% (UL30), 70.9% (UL39) and 62.6% (US6) respectively at the working concentration of 12.5 mug/mL.	Alkaloids	162-171	envelope glycoprotein D	Human alphaherpesvirus 1	115-118
20960307-8	2010	RT-PCR analysis showed that, the transcription of two important delayed early genes UL30 and UL39, and a late gene US6 of HSV-1 genome all were suppressed by the alkaloids extract, the expression inhibiting efficacy compared to the control was 74.6% (UL30), 70.9% (UL39) and 62.6% (US6) respectively at the working concentration of 12.5 mug/mL.	Alkaloids	162-171	DNA polymerase catalytic subunit	Human alphaherpesvirus 1	251-255
20960307-8	2010	RT-PCR analysis showed that, the transcription of two important delayed early genes UL30 and UL39, and a late gene US6 of HSV-1 genome all were suppressed by the alkaloids extract, the expression inhibiting efficacy compared to the control was 74.6% (UL30), 70.9% (UL39) and 62.6% (US6) respectively at the working concentration of 12.5 mug/mL.	Alkaloids	162-171	ribonucleotide reductase subunit 1	Human alphaherpesvirus 1	265-269
20960307-8	2010	RT-PCR analysis showed that, the transcription of two important delayed early genes UL30 and UL39, and a late gene US6 of HSV-1 genome all were suppressed by the alkaloids extract, the expression inhibiting efficacy compared to the control was 74.6% (UL30), 70.9% (UL39) and 62.6% (US6) respectively at the working concentration of 12.5 mug/mL.	Alkaloids	162-171	envelope glycoprotein D	Human alphaherpesvirus 1	282-285
21486531-5	2010	METHODS: The separation of the relevant alkaloids was carried out on a C18 column and detected at a UV wavelength of 228 nm.	Alkaloids	40-49	Bardet-Biedl syndrome 9	Homo sapiens	71-74
20138138-2	2010	We observed potent antiproliferative activities for both alkaloids against three tumour (HeLa; HL-60; A-2780) and two normal (V-79; LEP) cell lines.	Alkaloids	57-66	leptin	Cricetulus griseus	132-135
20387224-0	2010	Total alkaloids of Sophora alopecuroides increases the expression of CD4+ CD25+ Tregs and IL-10 in rats with experimental colitis.	Alkaloids	6-15	Cd4 molecule	Rattus norvegicus	69-72
20387224-0	2010	Total alkaloids of Sophora alopecuroides increases the expression of CD4+ CD25+ Tregs and IL-10 in rats with experimental colitis.	Alkaloids	6-15	interleukin 10	Rattus norvegicus	90-95
20410605-3	2010	To achieve this, we investigated the effects of the three alkaloids on the expression and function of P-glycoprotein/MDR1, MDR1 gene products, in vascular smooth muscle cells (VSMCs).	Alkaloids	58-67	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	117-121
20410605-3	2010	To achieve this, we investigated the effects of the three alkaloids on the expression and function of P-glycoprotein/MDR1, MDR1 gene products, in vascular smooth muscle cells (VSMCs).	Alkaloids	58-67	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	123-127
20009568-1	2010	In the present work, we demonstrate that microbial alkaloid staurosporine (STS) and Ro 31-8220, structurally related to STS protein kinase C inhibitor, caused development of membrane tubular extensions in human neutrophils upon adhesion to fibronectin-coated substrata.	Alkaloids	51-59	fibronectin 1	Homo sapiens	240-251
19836502-3	2009	Running buffer containing 40 mmol/L 1-butyl-3-methylimidazolium tetrafluoroborate (BMImBF(4)) IL-8 mmol/L phosphate resulted in significant changes in separation selectivity for alkaloids with similar structures.	Alkaloids	178-187	C-X-C motif chemokine ligand 8	Homo sapiens	83-98
20098609-1	2009	Granulatimide and isogranulatimide are alkaloids obtained from marine sources which have been shown to inhibit cell-cycle G2-checkpoint, targeting more particularly checkpoint 1 kinase (Chk1).	Alkaloids	39-48	checkpoint kinase 1	Homo sapiens	165-184
20098609-1	2009	Granulatimide and isogranulatimide are alkaloids obtained from marine sources which have been shown to inhibit cell-cycle G2-checkpoint, targeting more particularly checkpoint 1 kinase (Chk1).	Alkaloids	39-48	checkpoint kinase 1	Homo sapiens	186-190
19551611-9	2009	Investigation of the toxic potential of the alkaloids on HL-60 and HL-60/MX1 showed a significantly higher effect against HL-60/MX1, a multidrug-resistant cell line, compared with the control etoposide (p < 0.05).	Alkaloids	44-53	MX dynamin like GTPase 1	Homo sapiens	73-76
19551611-9	2009	Investigation of the toxic potential of the alkaloids on HL-60 and HL-60/MX1 showed a significantly higher effect against HL-60/MX1, a multidrug-resistant cell line, compared with the control etoposide (p < 0.05).	Alkaloids	44-53	MX dynamin like GTPase 1	Homo sapiens	128-131
19481591-3	2009	The alkaloids inhibited TNF-alpha and IL-6 production induced by these ligands.	Alkaloids	4-13	tumor necrosis factor	Mus musculus	24-33
19481591-3	2009	The alkaloids inhibited TNF-alpha and IL-6 production induced by these ligands.	Alkaloids	4-13	interleukin 6	Mus musculus	38-42
19555175-9	2009	The MD results clearly provide an explanation for the binding pattern of bulky steroidal alkaloids at the active site of AChE.	Alkaloids	89-98	acetylcholinesterase (Cartwright blood group)	Homo sapiens	121-125
19681075-2	2009	Highlights of the sequence are a diastereoselective construction of the C3a-bromo-hexahydropyrrolo[2,3-b]indole nucleus, its Co(I)-induced C3a-C3a" dimerization, and the twofold or sequential amide-bond formation before cyclization to the diketopiperazine of the homo- or heterodimeric alkaloids, respectively.	Alkaloids	286-295	complement C3	Homo sapiens	72-75
19681075-2	2009	Highlights of the sequence are a diastereoselective construction of the C3a-bromo-hexahydropyrrolo[2,3-b]indole nucleus, its Co(I)-induced C3a-C3a" dimerization, and the twofold or sequential amide-bond formation before cyclization to the diketopiperazine of the homo- or heterodimeric alkaloids, respectively.	Alkaloids	286-295	complement C3	Homo sapiens	139-142
19681075-2	2009	Highlights of the sequence are a diastereoselective construction of the C3a-bromo-hexahydropyrrolo[2,3-b]indole nucleus, its Co(I)-induced C3a-C3a" dimerization, and the twofold or sequential amide-bond formation before cyclization to the diketopiperazine of the homo- or heterodimeric alkaloids, respectively.	Alkaloids	286-295	complement C3	Homo sapiens	139-142
19591492-1	2009	The pentacyclic framework associated with the alkaloid (-)-lycorine (1) can be assembled in as few as six steps from the enantiomerically pure cis-1,2-dihydrocatechol 3 which is itself readily available on a large scale through the whole-cell biotransformation of bromobenzene.	Alkaloids	46-54	suppressor of cytokine signaling 1	Homo sapiens	143-148
19848203-1	2009	OBJECTIVE: To explore the effects of total alkaloids of Rubus alceaefolius Poiron (RAP) on gene expressions of drug-metabolic enzymes, CYP2E1 and CYP3A1 in liver.	Alkaloids	43-52	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	135-141
19848203-1	2009	OBJECTIVE: To explore the effects of total alkaloids of Rubus alceaefolius Poiron (RAP) on gene expressions of drug-metabolic enzymes, CYP2E1 and CYP3A1 in liver.	Alkaloids	43-52	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	146-152
19552464-0	2009	Design and synthesis of inhibitors of Hedgehog signaling based on the alkaloid cyclopamine.	Alkaloids	70-78	sonic hedgehog signaling molecule	Homo sapiens	38-46
19107738-4	2009	Influence of the alkaloids on the endothelial production of endothelial nitric oxide synthase (eNOS) was measured by quantitative polymerase chain reaction (QPCR) analysis.	Alkaloids	17-26	nitric oxide synthase 3	Rattus norvegicus	60-93
19894538-1	2009	OBJECTIVE: To study diterpenoid alkaloids from the roots of Aconitum recemulosum, and their inhibitory effects on PAF-induced platelet aggregation.	Alkaloids	32-41	PCNA clamp associated factor	Homo sapiens	114-117
19107738-4	2009	Influence of the alkaloids on the endothelial production of endothelial nitric oxide synthase (eNOS) was measured by quantitative polymerase chain reaction (QPCR) analysis.	Alkaloids	17-26	nitric oxide synthase 3	Rattus norvegicus	95-99
19346183-6	2009	Cytotoxic effects of both alkaloids were accompanied by activation of the intrinsic apoptotic pathway since we observed the dissipation of mitochondrial membrane potential, induction of caspase-9 and -3 activities, the appearance of sub-G(1) DNA and loss of plasma membrane asymmetry.	Alkaloids	26-35	caspase 9	Homo sapiens	186-202
19673335-1	2009	OBJECTIVE: To explore the effect and possible cell signal transduction mechanism of active components (alkaloids and glucosides) of Buyang Huanwu Decoction (BHD) on the vascular adhesion molecule (VAM) expression induced by thrombin (Thr).	Alkaloids	103-112	coagulation factor II, thrombin	Homo sapiens	224-232
26493134-7	2009	Due to their role in primary (lignin) and secondary (phenolics, e.g., vanillin, alkaloids) metabolisms, COMT genes might not be neutral markers, and represent candidate functional markers for resistance, aromatic or medicinal properties of Vanilla species.	Alkaloids	80-89	catechol-O-methyltransferase	Homo sapiens	104-108
19336898-6	2009	Our findings should encourage screening of other natural alkaloids for possible anti-h-PTP 1B activities.	Alkaloids	57-66	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	87-93
19368123-1	2009	The aim of the present study was to investigate the anticancer properties of five alkaloids isolated from Amaryllidaceae, including the inhibitory effect on P-glycoprotein (P-gp) and the apoptosis-inducing capacity.	Alkaloids	82-91	phosphoglycolate phosphatase	Mus musculus	157-171
19329999-5	2009	Using this method, we identify the bioactive alkaloid emetine as a selective inhibitor of the uncharacterized cancer-associated hydrolase RBBP9.	Alkaloids	45-53	RB binding protein 9, serine hydrolase	Homo sapiens	138-143
19240946-1	2009	Alkaloids from the plants of Amaryllidaceae family consists of an unique class of nitrogen-containing compounds showing diverse and significant biological activities, including anticancer and acetylcholinesterase (AChE) inhibitory activities.	Alkaloids	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	192-212
19240946-1	2009	Alkaloids from the plants of Amaryllidaceae family consists of an unique class of nitrogen-containing compounds showing diverse and significant biological activities, including anticancer and acetylcholinesterase (AChE) inhibitory activities.	Alkaloids	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	214-218
19101888-0	2009	Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala.	Alkaloids	33-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
19101888-2	2009	The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated.	Alkaloids	65-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-50
19101888-2	2009	The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated.	Alkaloids	65-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	52-56
19148863-3	2009	In vitro, four alkaloids showed anti-inflammatory activities, with inhibition rates of release of beta-glucuronidase from polymorphonuclear leukocytes of rats being in the range 34.8%-39.6% at 10 microM.	Alkaloids	15-24	glucuronidase, beta	Rattus norvegicus	98-116
19281537-0	2009	An alkaloid extract of Evanta, traditionally used as anti-Leishmania agent in Bolivia, inhibits cellular proliferation and interferon-gamma production in polyclonally activated cells.	Alkaloids	3-11	interferon gamma	Homo sapiens	123-139
19368123-1	2009	The aim of the present study was to investigate the anticancer properties of five alkaloids isolated from Amaryllidaceae, including the inhibitory effect on P-glycoprotein (P-gp) and the apoptosis-inducing capacity.	Alkaloids	82-91	phosphoglycolate phosphatase	Mus musculus	173-177
19368123-2	2009	The tested alkaloids were evaluated for their multidrug resistance (MDR)-reversing activity on human MDR1-gene-transfected L5178 mouse lymphoma cells, using the rhodamine-123 (Rh-123) assay.	Alkaloids	11-20	ATP binding cassette subfamily B member 1	Homo sapiens	101-105
19023536-0	2008	Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase.	Alkaloids	29-38	aldo-keto reductase family 1 member B1	Rattus norvegicus	69-85
19521913-0	2009	Alkaloids from Mongolian species Hypecoum lactiflorum Kar.	Alkaloids	0-9	KAR	Homo sapiens	54-57
19106635-2	2008	Here we further examined the anti-tumor effects of selected compounds in vitro and showed that NSC176327, a derivative of the cytotoxic plant alkaloid ellipticine, exhibited strong anti-neoplastic effect sin wild-type p53, p53-mutant or p53-deficient human colon cancer cells.	Alkaloids	142-150	RNA polymerase III subunit E	Homo sapiens	204-207
18855481-1	2008	Enantiomeric pairs of the cytotoxic pyrroloiminoquinone marine alkaloids discorhabdins B (2), G*/I (3), L (4), and W (5) have been isolated from Latrunculia species sponges collected at different locations around the coast of New Zealand.	Alkaloids	63-72	ribosomal protein L4	Homo sapiens	94-120
19924219-1	2008	We describe a concise and convergent route to the core matrix of the cortistatin steroidal alkaloids.	Alkaloids	91-100	cortistatin	Homo sapiens	69-80
18601993-0	2008	Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii.	Alkaloids	55-64	butyrylcholinesterase	Mus musculus	0-14
19035304-2	2008	The tested alkaloids were evaluated for multidrug resistance (MDR)-reversing activity on human Pgp-transfected L5178 mouse lymphoma cells, using the rhodamine-123 (Rh-123) assay.	Alkaloids	11-20	phosphoglycolate phosphatase	Homo sapiens	95-98
18717490-1	2008	This study demonstrated that the total alkaloids isolated from the traditional Chinese medicinal herb Solanum nigrum Linne (SNL-A) inhibited the growth of human cervical cancer HeLa cells in culture medium with much lower toxicity to human normal lymphocytes.	Alkaloids	39-48	fascin actin-bundling protein 1	Homo sapiens	124-127
18664354-9	2008	The expressions of PCNA in alkaloids, glycosides, and atorvastatin groups were higher than that in the sham-operated group (P<0.01, P<0.05), but still lower than that in the untreated group (P<0.01).	Alkaloids	27-36	proliferating cell nuclear antigen	Rattus norvegicus	19-23
18664354-12	2008	Alkaloids and glycoside may be among basal substances in BYHWD inhibiting intimal hyperplasia of blood vessel, the effect of which may relate to down-regulating the expression of PCNA.	Alkaloids	0-9	proliferating cell nuclear antigen	Rattus norvegicus	179-183
18492687-7	2008	Formation of tobacco alkaloids in jasmonate-elicited tobacco BY-2 cells was also effectively suppressed by the COI1 RNAi (RNA interference) construct and by the dominant-negative truncated JAZ constructs.	Alkaloids	21-30	coronatine-insensitive protein 1-like	Nicotiana tabacum	111-115
18541917-1	2008	Previously, we demonstrated that the action of the natural alkaloid, ibogaine, to reduce alcohol (ethanol) consumption is mediated by the glial cell line-derived neurotrophic factor (GDNF) in the ventral tegmental area (VTA).	Alkaloids	59-67	glial cell derived neurotrophic factor	Rattus norvegicus	138-181
18541917-1	2008	Previously, we demonstrated that the action of the natural alkaloid, ibogaine, to reduce alcohol (ethanol) consumption is mediated by the glial cell line-derived neurotrophic factor (GDNF) in the ventral tegmental area (VTA).	Alkaloids	59-67	glial cell derived neurotrophic factor	Rattus norvegicus	183-187
18358694-6	2008	Decrease in the viability induced by both alkaloids was accompanied by apoptotic events including the dissipation of mitochondrial membrane potential, activation of caspase-9 and -3, and appearance of cells with sub-G1 DNA.	Alkaloids	42-51	caspase 9	Homo sapiens	165-181
18201739-6	2008	The CYP3A1 protein expression was evaluated using primary rat hepatocellular cultures treated with ergovaline, one of the major ergot alkaloids produced by fescue endophyte, in order to assess the direct role of ergot alkaloids in CYP induction.	Alkaloids	134-143	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	4-10
18293087-0	2008	Promotion of cell death or neurite outgrowth in PC-12 and N2a cells by the fungal alkaloid militarinone A depends on basal expression of p53.	Alkaloids	82-90	transformation related protein 53, pseudogene	Mus musculus	137-140
17967353-10	2007	The trehalase activities of S. ricini were lower and inhibited by lower concentrations of sugar-mimic alkaloids than those of B. mori.	Alkaloids	102-111	trehalase	Bombyx mori	4-13
26524987-1	2008	Opioids can be classified according to their mode of synthesis into alkaloids, semi-synthetic and synthetic compounds.There are three classical receptors (DOP, KOP and MOP).	Alkaloids	68-77	opioid receptor mu 1	Homo sapiens	168-171
18157518-0	2008	Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1).	Alkaloids	33-41	solute carrier family 22 member 1	Homo sapiens	101-129
18157518-0	2008	Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1).	Alkaloids	33-41	solute carrier family 22 member 1	Homo sapiens	131-135
18157518-0	2008	Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1).	Alkaloids	33-41	ATP binding cassette subfamily B member 1	Homo sapiens	166-170
18157518-0	2008	Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1).	Alkaloids	33-41	ATP binding cassette subfamily B member 1	Homo sapiens	187-192
18296268-1	2008	Milky sap isolated from Chelidonium majus L. (Greater Celandine) serves as a rich source of various biologically active substances such as alkaloids, flavonoids and phenolic acids.	Alkaloids	139-148	SH2 domain containing 1A	Homo sapiens	6-9
18052329-1	2008	Four new alkaloids, pterocellins C-F (1-4), have been isolated from the New Zealand marine bryozoan Pterocella vesiculosa.	Alkaloids	9-18	ATPase H+ transporting accessory protein 1	Homo sapiens	33-41
17967353-11	2007	These results suggest that sugar-mimic alkaloids in mulberry latex exert toxicity to S. ricini larvae first by inhibiting midgut sucrase and digestion of sucrose, and secondly, after being absorbed into hemolymph, by inhibiting trehalase and utilization of trehalose, the major blood sugar.	Alkaloids	39-48	trehalase	Bombyx mori	228-237
17508763-2	2007	The first total synthesis of the 15-membered ring cyclopeptide alkaloid abyssenine A 1 has been achieved with a longest linear sequence of 15 steps.	Alkaloids	63-71	BCL2 related protein A1	Homo sapiens	83-86
17917418-3	2007	This review describes the stereochemistry of lupine alkaloids and focuses on the conformational flexibility of nitrogen-fused systems such as quinolizidine and indolizidine, syntheses of new unusual types of alkaloids from known lupine alkaloids, and pharmacological activity of lupine alkaloids, especially kappa-opioid receptor-mediated antinociceptive effects of matrine-type lupine alkaloids.	Alkaloids	208-217	opioid receptor kappa 1	Homo sapiens	308-329
17295371-6	2007	The alkaloid berberine was the prolyl oligopeptidase inhibitory molecule isolated from Rhizoma coptidis extract.	Alkaloids	4-12	prolyl endopeptidase	Homo sapiens	31-52
17713646-7	2007	IL-4 and total IgE were decreased (939 +/- 447 pg/mL and 2.03 +/- 0.42 IU/mL, respectively) in serum from mice treated with alkaloids and albendazole compared with the untreated control (1481 +/- 619 pg/mL and 3.31 +/- 0.37 IU/mL; P < 0.01).	Alkaloids	124-133	interleukin 4	Mus musculus	0-4
18069241-2	2007	Among the alkaloids tested, only capsaicin exerted a remarkable inhibitory effect towards both AChE and BChE [(62.7 +/- 0.79)% and (75.3 +/- 0.98)%, respectively].	Alkaloids	10-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-99
18069241-2	2007	Among the alkaloids tested, only capsaicin exerted a remarkable inhibitory effect towards both AChE and BChE [(62.7 +/- 0.79)% and (75.3 +/- 0.98)%, respectively].	Alkaloids	10-19	butyrylcholinesterase	Homo sapiens	104-108
18069241-3	2007	While the rest of the alkaloids did not show any significant inhibition against AChE, three of the alkaloids, namely retamine, sparteine, and yohimbine, exerted a noteworthy anti-BChE effect as compared to galanthamine, the reference drug.	Alkaloids	99-108	butyrylcholinesterase	Homo sapiens	179-183
17653364-1	2007	A great number of natural products, especially alkaloids, which exhibit a range of biological activities including acetylcholinesterase inhibition and antineoplastic, cardiovascular and immunostimulatory activities, have been isolated from the plants of the Amaryllidaceae family.	Alkaloids	47-56	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-135
17462892-1	2007	A small series of derivatives of the alkaloid naamidine A was synthesized and tested in vitro for their ability to inhibit mitogenesis in BaF/ERX cells.	Alkaloids	37-45	BAF nuclear assembly factor 1	Homo sapiens	138-141
17464044-5	2007	The NRP synthetases GliP and FtmA respectively direct the biosynthesis of the toxic metabolites gliotoxin and brevianamide F, a precursor of bioactive prenylated alkaloids.	Alkaloids	162-171	neuropilin 1	Homo sapiens	4-7
17520475-1	2007	Understanding the nature of the interaction of the plant alkaloid ryanodine with its receptor channel (RyR) is important to aid interpretation of physiological studies and provide structure-function information about RyR.	Alkaloids	57-65	ryanodine receptor 2	Homo sapiens	103-106
17520475-1	2007	Understanding the nature of the interaction of the plant alkaloid ryanodine with its receptor channel (RyR) is important to aid interpretation of physiological studies and provide structure-function information about RyR.	Alkaloids	57-65	ryanodine receptor 2	Homo sapiens	217-220
17316993-0	2007	Fos-like immunoreactivity in rat dorsal raphe nuclei induced by alkaloid extract of Mitragyna speciosa.	Alkaloids	64-72	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
17536728-9	2007	In the HPLC-APCI/ MSn analysis, there was an interesting phenomenon that the relative abundance of the ions M+ and [M + 2]+ was different for different alkaloids.	Alkaloids	152-161	moesin	Homo sapiens	18-21
17510939-1	2007	The fragmentation mechanism of six alkaloids, namely: dihydronitidine, dihydrochelerythrine, 8-acetonyldihydronitidine, 8-acetonyldrochelerythrine, nitidine and 1,3-bis(8-dihydronitidinyl)acetone, was investigated by electrospray ionization multi-stage tandem mass spectrometry (ESI-MSn).	Alkaloids	35-44	moesin	Homo sapiens	283-286
17578319-0	2007	Protective effects and mechanism of total coptis alkaloids on a beta 25-35 induced learning and memory dysfunction in rats.	Alkaloids	49-58	amyloid beta precursor protein	Rattus norvegicus	62-68
18050962-1	2007	Glycosyltransferase family 1 (UGT) uses small chemicals including phenolics, antibiotics, and alkaloids as substrates to have an influence in biological activities.	Alkaloids	94-103	glycosyl transferase	Escherichia coli	0-19
17157545-4	2007	Agl12 expression selectively increases the expression of genes encoding enzymes involved in the early biosynthesis steps of the terpenic precursor of alkaloids.	Alkaloids	150-159	AGAMOUS-like 12	Arabidopsis thaliana	0-5
17188496-0	2007	Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase.	Alkaloids	22-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-89
17027747-2	2006	Alkaloids having anticholinergic effect on guinea-pig tracheal smooth muscle were screened out and their mechanism was further studied on the cAMP formation in Chinese hamster ovary cells stably expressing human muscarinic M2 receptor (CHO-hM2 cells) and intracellular calcium ([Ca(2+)](i)) transient in Chinese hamster ovary cells stably expressing human muscarinic M3 receptor (CHO-hM3 cells).	Alkaloids	0-9	cholinergic receptor muscarinic 2	Homo sapiens	212-234
16783693-0	2006	Reduction of cytotoxicity of the alkaloid emetine through P-glycoprotein (MDR1/ABCB1) in human Caco-2 cells and leukemia cell lines.	Alkaloids	33-41	ATP binding cassette subfamily B member 1	Homo sapiens	58-72
16783693-0	2006	Reduction of cytotoxicity of the alkaloid emetine through P-glycoprotein (MDR1/ABCB1) in human Caco-2 cells and leukemia cell lines.	Alkaloids	33-41	ATP binding cassette subfamily B member 1	Homo sapiens	74-78
16783693-0	2006	Reduction of cytotoxicity of the alkaloid emetine through P-glycoprotein (MDR1/ABCB1) in human Caco-2 cells and leukemia cell lines.	Alkaloids	33-41	ATP binding cassette subfamily B member 1	Homo sapiens	79-84
16867986-6	2006	We also provide experiments showing that human Smo, when expressed in Schneider cells, is able to bind the alkaloid cyclopamine, suggesting that it is expressed in a native conformational state.	Alkaloids	107-115	smoothened, frizzled class receptor	Homo sapiens	47-50
16442763-6	2006	Therefore, this paper indicate that the major alkaloids present in the seed of Strychnos nux-vomica are effective against HepG2 cells proliferation, among which brucine proceed HepG2 cells death via apoptosis, probably through the participation of caspase-3 and cyclooxygenase-2.	Alkaloids	46-55	caspase 3	Homo sapiens	248-257
17193337-0	2006	New cholinesterase-inhibiting triterpenoid alkaloids from Buxus hyrcana.	Alkaloids	43-52	butyrylcholinesterase	Homo sapiens	4-18
16881015-4	2006	The effects of the five alkaloids on human red blood cell (RBC) acetylcholinesterase (AChE) and human plasma butyrylcholinesterase (BChE) were further studied, and their IC (50) values for human RBC AChE were 6.4 +/- 0.003 microM, 16.9 +/- 0.018 microM, 5.7 +/- 0.004 microM, 6.5 +/- 0.013 microM and 7.7 +/- 0.001 microM, respectively, and the IC50 values for human plasma BChE were 12.5 +/- 0.026 microM, 2.1 +/- 0.005 microM, 5.2 +/- 0.002 microM, 7.3 +/- 0.005 microM and 0.7 +/- 0.001 microM, respectively.	Alkaloids	24-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	86-90
16756287-1	2006	Double diastereoselection in alkaloid-catalyzed acyl halide-aldehyde cyclocondensation (AAC) reactions provides a strategy for realizing syn- or anti-selective propionate aldol additions from a common reaction manifold.	Alkaloids	29-37	glycine-N-acyltransferase	Homo sapiens	88-91
16756287-1	2006	Double diastereoselection in alkaloid-catalyzed acyl halide-aldehyde cyclocondensation (AAC) reactions provides a strategy for realizing syn- or anti-selective propionate aldol additions from a common reaction manifold.	Alkaloids	29-37	synemin	Homo sapiens	137-140
16442763-6	2006	Therefore, this paper indicate that the major alkaloids present in the seed of Strychnos nux-vomica are effective against HepG2 cells proliferation, among which brucine proceed HepG2 cells death via apoptosis, probably through the participation of caspase-3 and cyclooxygenase-2.	Alkaloids	46-55	prostaglandin-endoperoxide synthase 2	Homo sapiens	262-278
21783666-1	2006	Apart from its own controversial cytogenotoxic effects, caffeine (CAF), one of the most commonly consumed alkaloids worldwide, is found potentiative to and so also protective from the cytogenotoxic effects of numerous chemical and physical mutagens.	Alkaloids	106-115	caffeine susceptibility	Mus musculus	66-69
16545497-3	2006	The alkaloid epibatidine is a highly potent non-opioid analgesic and nAChR agonist, but too toxic to be a useful ligand.	Alkaloids	4-12	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	69-74
16635744-5	2006	In addition, both caspase-9 and caspase-3 were also time-dependently activated upon treatment with the alkaloids.	Alkaloids	103-112	caspase 9	Homo sapiens	18-27
16635744-5	2006	In addition, both caspase-9 and caspase-3 were also time-dependently activated upon treatment with the alkaloids.	Alkaloids	103-112	caspase 3	Homo sapiens	32-41
16635744-6	2006	Caspase-9 and caspase-3 inhibitors suppressed apoptosis induced by these alkaloids.	Alkaloids	73-82	caspase 9	Homo sapiens	0-9
16635744-6	2006	Caspase-9 and caspase-3 inhibitors suppressed apoptosis induced by these alkaloids.	Alkaloids	73-82	caspase 3	Homo sapiens	14-23
16635744-7	2006	The results suggest that these three alkaloids induced apoptosis in HL-60 cells through activation of the caspase-9/caspase-3 pathway, through mitochondrial dysfunction.	Alkaloids	37-46	caspase 9	Homo sapiens	106-115
16635744-7	2006	The results suggest that these three alkaloids induced apoptosis in HL-60 cells through activation of the caspase-9/caspase-3 pathway, through mitochondrial dysfunction.	Alkaloids	37-46	caspase 3	Homo sapiens	116-125
16300809-0	2006	Alkaloids from Oriciopsis glaberrima Engl.	Alkaloids	0-9	exo/endonuclease G	Homo sapiens	37-41
16841672-9	2006	CONCLUSION: Alkaloid, glycoside, polysaccharide and aglycone from BYHWD could relieve the inflammatory reaction occurred after cerebral ischemia/reperfusion by inhibiting caspase-1 expression to decrease production of inflammatory cytokine.	Alkaloids	12-20	caspase 1	Rattus norvegicus	171-180
16841672-10	2006	Alkaloid, glycoside and aglycone could reduce neuronal apoptosis by inhibiting caspase-3 expression to antagonize the delayed neuronal death after cerebral ischemia.	Alkaloids	0-8	caspase 3	Rattus norvegicus	79-88
16289854-2	2006	Colchicine, a naturally occurring alkaloid, is a Pgp substrate and acts as an antimitotic agent by binding to microtubules.	Alkaloids	34-42	phosphoglycolate phosphatase	Mus musculus	49-52
16491444-4	2006	Due to different carbon chains attached to C-9 of the pyrroloazepine nucleus they were classified into stichoneurine-, protostemonine- and croomine-type alkaloids.	Alkaloids	153-162	complement component C9	Cavia porcellus	43-46
16272741-3	2005	This comparison indicated that simply methods as C18 RP-HPLC and GC are the more effective techniques, and more suitable than others for this preparation, for the separation of two alkaloids.	Alkaloids	181-190	Bardet-Biedl syndrome 9	Homo sapiens	49-52
17080553-0	2006	The effects of five alkaloids from Bulbus Fritillariae on the concentration of cAMP in HEK cells transfected with muscarinic M(2) receptor plasmid.	Alkaloids	20-29	cholinergic receptor muscarinic 2	Homo sapiens	114-138
17080553-5	2006	And the results suggested that the five alkaloids could significantly elevate the cAMP concentration in the HEK cells transfected with muscarinic M(2) receptor plasmid (p < 0.01).	Alkaloids	40-49	cholinergic receptor muscarinic 2	Homo sapiens	135-159
16557496-4	2006	The loss of CH3 or the OCH3 group in those alkaloids, which have an OCH3 substituent, was the dominant fragmentation mode in the MS3 fragmentations.	Alkaloids	43-52	MS3	Homo sapiens	129-132
16366712-0	2005	Binding of the pepper alkaloid piperine to bovine beta-lactoglobulin: circular dichroism spectroscopy and molecular modeling study.	Alkaloids	22-30	beta-lactoglobulin	Bos taurus	50-68
15944212-6	2005	The generation of reactive oxygen species (ROS) in endothelial cells stimulated with Ang-II was inhibited significantly by the three alkaloids tested.	Alkaloids	133-142	angiotensinogen	Homo sapiens	85-91
29350806-6	2005	The generation of reactive oxygen species (ROS) in endothelial cells stimulated with Ang-II was inhibited significantly by the three alkaloids tested.	Alkaloids	133-142	angiotensinogen	Homo sapiens	85-91
16079618-6	2005	Meanwhile, the expression of PCNA and mutant p53 protein positive cell numbers in mice bearing H(22) hepatocellular carcinoma also suppressed by alkaloid (p<0.05).	Alkaloids	145-153	proliferating cell nuclear antigen	Mus musculus	29-33
16188140-8	2005	CONCLUSION: Transcription of CYP3A5 gene in leukemia cells directly induces resistance to anthracyclines and alkaloids, however the cells are still sensitive to epipodophyllotoxins.	Alkaloids	109-118	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	29-35
15938198-0	2005	Tyrosinase inhibition studies of diterpenoid alkaloids and their derivatives: structure-activity relationships.	Alkaloids	45-54	tyrosinase	Homo sapiens	0-10
16042076-6	2005	Of the eight alkaloids, gamma-fagarine was the most potent inhibitor of PDE5A, and its single methoxy group at the C-8 position was shown to be critical for inhibitory activity.	Alkaloids	13-22	phosphodiesterase 5A	Homo sapiens	72-77
15974606-3	2005	The inhibitory activities of the selected alkaloids on topoisomerase I and II and their cytotoxicity against the human promyelocytic leukemia (HL-60) cell lines were assessed.	Alkaloids	42-51	PML nuclear body scaffold	Homo sapiens	119-148
15848192-1	2005	In this study, the human cytochrome P450 (CYP) 2A6 was used in order to modify the alkaloid production of tobacco plants.	Alkaloids	83-91	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	25-50
16079618-6	2005	Meanwhile, the expression of PCNA and mutant p53 protein positive cell numbers in mice bearing H(22) hepatocellular carcinoma also suppressed by alkaloid (p<0.05).	Alkaloids	145-153	transformation related protein 53, pseudogene	Mus musculus	45-48
15725500-0	2005	Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine.	Alkaloids	71-80	butyrylcholinesterase	Homo sapiens	32-53
15787439-0	2005	Psychopharmacological profile of the alkaloid psychollatine as a 5HT2A/C serotonin modulator.	Alkaloids	37-45	5-hydroxytryptamine receptor 2A	Homo sapiens	65-70
15177499-1	2004	Halofuginone, a widely used alkaloid coccidiostat, is a potent inhibitor of collagen alpha 1 (I) and matrix metalloproteinase 2 gene expression.	Alkaloids	28-36	matrix metallopeptidase 2	Mus musculus	101-127
16711384-0	2005	[Effect of alkaloid sanguinarine and a pharmaceutical preparation ukrain on modulation of vesicular membrane fusion and actin cytoskeleton of macrophages].	Alkaloids	11-19	actin	Oryctolagus cuniculus	120-125
16711384-1	2005	A study was made of modulations of lysosome-phagosome fusion process and of fibrillar actin content in mouse peritoneal macrophages by an antitumor alkaloid sanguinarine and a derivative drug Ukrain.	Alkaloids	148-156	actin	Oryctolagus cuniculus	86-91
15504755-0	2004	Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell.	Alkaloids	6-14	NFKB inhibitor alpha	Homo sapiens	41-53
15504755-0	2004	Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell.	Alkaloids	6-14	NFKB inhibitor alpha	Homo sapiens	62-74
15504755-0	2004	Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell.	Alkaloids	6-14	nuclear factor kappa B subunit 1	Homo sapiens	75-84
15795993-0	2004	Cholinesterase inhibitory and spasmolytic potential of steroidal alkaloids.	Alkaloids	65-74	cholinesterase	Oryctolagus cuniculus	0-14
15795993-5	2004	Structure-activity relationship suggested that the nitrogen substituents at C-3 and/or C-20 of steroidal skeleton and the hydrophobic properties of the pregnane skeleton are the key structural features contributed to the inhibitory potency of these steroidal alkaloids against AChE and BChE.	Alkaloids	259-268	ACE-1	Oryctolagus cuniculus	277-281
15795993-5	2004	Structure-activity relationship suggested that the nitrogen substituents at C-3 and/or C-20 of steroidal skeleton and the hydrophobic properties of the pregnane skeleton are the key structural features contributed to the inhibitory potency of these steroidal alkaloids against AChE and BChE.	Alkaloids	259-268	cholinesterase	Oryctolagus cuniculus	286-290
15567973-1	2004	BACKGROUND: We have identified a novel mu opiate receptor, p3, which is expressed in several human tissues, is selective for opiate alkaloids, insensitive to opioid peptides, and also is coupled to constitutive nitric oxide release.	Alkaloids	132-141	opioid receptor mu 1	Homo sapiens	39-57
15648263-0	2004	Marine alkaloid polycarpine and its synthetic derivative dimethylpolycarpine induce apoptosis in JB6 cells through p53- and caspase 3-dependent pathways.	Alkaloids	7-15	tumor protein p53	Homo sapiens	115-118
15648263-0	2004	Marine alkaloid polycarpine and its synthetic derivative dimethylpolycarpine induce apoptosis in JB6 cells through p53- and caspase 3-dependent pathways.	Alkaloids	7-15	caspase 3	Homo sapiens	124-133
15342389-9	2004	Exposure to cyclopamine, a steroidal alkaloid that blocks the Hh pathway, suppresses expression of Gli1 and the growth of the Hh pathway-activated breast carcinoma cells.	Alkaloids	37-45	GLI family zinc finger 1	Homo sapiens	99-103
15109670-1	2004	Zoanthamines are a family of marine alkaloids that have complex heptacyclic structures and are reported to be interleukin-6 modulators.	Alkaloids	36-45	interleukin 6	Homo sapiens	110-123
14757175-0	2004	Nicotine-related alkaloids and metabolites as inhibitors of human cytochrome P-450 2A6.	Alkaloids	17-26	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	66-86
15120460-0	2004	Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.	Alkaloids	48-57	monoamine oxidase A	Rattus norvegicus	14-19
15148683-5	2004	This review gives an overview of the occurrence and importance of beta2-amino acids in nature, placing emphasis on the metabolic pathways of beta-aminoisobutyric acid (beta-Aib) and the appearance of beta2-amino acids as secondary metabolites or as components of more complex natural products, such as peptides, depsipeptides, lactones, and alkaloids.	Alkaloids	341-350	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	66-71
15148683-5	2004	This review gives an overview of the occurrence and importance of beta2-amino acids in nature, placing emphasis on the metabolic pathways of beta-aminoisobutyric acid (beta-Aib) and the appearance of beta2-amino acids as secondary metabolites or as components of more complex natural products, such as peptides, depsipeptides, lactones, and alkaloids.	Alkaloids	341-350	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	200-205
14757175-3	2004	The tobacco alkaloids 2,3"-bipyridyl (7.7 microM) and S-(-)-anabasine (5.4 microM), were somewhat less potent compared with S-(-)-nicotine or S-(-)-anatabine in inhibition of human CYP2A6.	Alkaloids	12-21	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	181-187
14757175-6	2004	The potency of the mechanism-based CYP2A6 inhibitors suggests that, for smokers, modulation of CYP2A6 may be greater than that predicted on the basis of serum concentration of these alkaloids.	Alkaloids	182-191	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	35-41
15185841-0	2004	Involvement of NF-kappaB and c-myc signaling pathways in the apoptosis of HL-60 cells induced by alkaloids of Tripterygium hypoglaucum (levl.)	Alkaloids	97-106	nuclear factor kappa B subunit 1	Homo sapiens	15-24
15185841-0	2004	Involvement of NF-kappaB and c-myc signaling pathways in the apoptosis of HL-60 cells induced by alkaloids of Tripterygium hypoglaucum (levl.)	Alkaloids	97-106	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	29-34
15185841-4	2004	In the present study, alkaloids of THH were prepared and their cytotoxicity against the HL-60 cell was investigated.	Alkaloids	22-31	trichohyalin	Homo sapiens	35-38
15182636-0	2004	[Effects of total alkaloids of Tongbiling prescription on Th1 type cytokine expression in T lymphocytes].	Alkaloids	18-27	negative elongation factor complex member C/D, Th1l	Mus musculus	58-61
14727511-10	2003	We examined the effects of frog alkaloids on nAChRs expressed in Xenopus oocytes, and found that indolizidines 235B" selectively blocked alpha 4 beta 2-nAChR.	Alkaloids	32-41	hemoglobin, beta adult minor chain	Mus musculus	145-151
14559857-11	2003	Both alkaloids inhibited Ang-II-induced endothelial P-selectin upregulation and the generation of reactive oxygen species (ROS) in endothelial cells stimulated with Ang-II, in fMLP-stimulated human neutrophils (PMNs) and in the hypoxanthine-xanthine oxidase system.	Alkaloids	5-14	angiotensinogen	Homo sapiens	25-31
14559857-11	2003	Both alkaloids inhibited Ang-II-induced endothelial P-selectin upregulation and the generation of reactive oxygen species (ROS) in endothelial cells stimulated with Ang-II, in fMLP-stimulated human neutrophils (PMNs) and in the hypoxanthine-xanthine oxidase system.	Alkaloids	5-14	selectin P	Homo sapiens	52-62
14559857-11	2003	Both alkaloids inhibited Ang-II-induced endothelial P-selectin upregulation and the generation of reactive oxygen species (ROS) in endothelial cells stimulated with Ang-II, in fMLP-stimulated human neutrophils (PMNs) and in the hypoxanthine-xanthine oxidase system.	Alkaloids	5-14	angiotensinogen	Homo sapiens	165-171
14559857-11	2003	Both alkaloids inhibited Ang-II-induced endothelial P-selectin upregulation and the generation of reactive oxygen species (ROS) in endothelial cells stimulated with Ang-II, in fMLP-stimulated human neutrophils (PMNs) and in the hypoxanthine-xanthine oxidase system.	Alkaloids	5-14	formyl peptide receptor 1	Homo sapiens	176-180
14727511-10	2003	We examined the effects of frog alkaloids on nAChRs expressed in Xenopus oocytes, and found that indolizidines 235B" selectively blocked alpha 4 beta 2-nAChR.	Alkaloids	32-41	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	45-50
12672796-2	2003	Endogenous human delta-opioid receptors (hDOR) are differentially regulated in terms of desensitization by peptide ([d-Pen2,5]enkephalin (DPDPE) and Deltorphin I) and alkaloid (etorphine) agonists in the neuroblastoma cell line SK-N-BE (Allouche, S., Roussel, M., Marie, N., and Jauzac, P. (1999) Eur.	Alkaloids	167-175	tumor protein p53 inducible nuclear protein 2	Homo sapiens	41-45
12960405-4	2003	The two alkaloids were accumulated in skin unchanged except for the three species of Dendrobates, where approximately 80% of accumulated PTX (+)-251D was stereoselectively hydroxylated to aPTX (+)-267A.	Alkaloids	8-17	aprataxin	Mus musculus	188-192
12956941-0	2003	Codonopsis pilosula (Franch) Nannf total alkaloids potentiate neurite outgrowth induced by nerve growth factor in PC12 cells.	Alkaloids	41-50	nerve growth factor	Rattus norvegicus	91-110
12956941-1	2003	AIM: To explore the effect of Codonopsis pilosula (Franch) Nannf total alkaloids (DSA) on differentiation induced by nerve growth factor (NGF) in PC12 cells.	Alkaloids	71-80	nerve growth factor	Rattus norvegicus	117-136
12956941-1	2003	AIM: To explore the effect of Codonopsis pilosula (Franch) Nannf total alkaloids (DSA) on differentiation induced by nerve growth factor (NGF) in PC12 cells.	Alkaloids	71-80	nerve growth factor	Rattus norvegicus	138-141
12885861-6	2003	1 microM auxin reduced calystegine levels in control roots, while in pmt-overexpressing roots all alkaloids remained unaltered.	Alkaloids	98-107	putrescine N-methyltransferase 3	Nicotiana tabacum	69-72
12903959-5	2003	Alkaloids 3, 4, and 6 showed a potent inhibitory activity toward rat lysosomal beta-glucosidase, with IC(50) values of 2.1, 0.75, and 0.84 microM, respectively, and alkaloid 5 was a moderate inhibitor of alpha- and beta-mannosidases.	Alkaloids	0-9	mannosidase beta	Rattus norvegicus	204-232
12889910-0	2003	Enantiospecific formal total synthesis of the tumor and GSK-3 beta inhibiting alkaloid, (-)-agelastatin A.	Alkaloids	78-86	glycogen synthase kinase 3 beta	Homo sapiens	56-66
12492320-2	2002	The key intermediate syn-3,4-epoxyalcohol was prepared in a highly diastereomeric fashion (>99% ee, dr) and served as a common intermediate for both alkaloids.	Alkaloids	152-161	synapsin III	Homo sapiens	21-26
12490309-3	2003	The results revealed that I3C significantly reversed the over-expression of P-gp in vinca-alkaloid induced drug resistance as evident by Western blotting using monoclonal antibody (clone JSB1).	Alkaloids	90-98	ATP binding cassette subfamily B member 1	Homo sapiens	76-80
12790770-4	2003	In addition, a subtle but consistent inhibition of the intermediate-MW form of DPP-IV-like enzyme activity, ascribed to DPP-IV/CD26, observed only in human plasma and of the attractin (high-MW form of DPP-IV-like enzyme activity, expressed in U87 glioma cells) by the studied alkaloids was observed.	Alkaloids	276-285	dipeptidyl peptidase 4	Homo sapiens	79-85
12790770-4	2003	In addition, a subtle but consistent inhibition of the intermediate-MW form of DPP-IV-like enzyme activity, ascribed to DPP-IV/CD26, observed only in human plasma and of the attractin (high-MW form of DPP-IV-like enzyme activity, expressed in U87 glioma cells) by the studied alkaloids was observed.	Alkaloids	276-285	dipeptidyl peptidase 4	Homo sapiens	120-126
12790770-4	2003	In addition, a subtle but consistent inhibition of the intermediate-MW form of DPP-IV-like enzyme activity, ascribed to DPP-IV/CD26, observed only in human plasma and of the attractin (high-MW form of DPP-IV-like enzyme activity, expressed in U87 glioma cells) by the studied alkaloids was observed.	Alkaloids	276-285	attractin	Homo sapiens	174-183
12790770-4	2003	In addition, a subtle but consistent inhibition of the intermediate-MW form of DPP-IV-like enzyme activity, ascribed to DPP-IV/CD26, observed only in human plasma and of the attractin (high-MW form of DPP-IV-like enzyme activity, expressed in U87 glioma cells) by the studied alkaloids was observed.	Alkaloids	276-285	dipeptidyl peptidase 4	Homo sapiens	120-126
12410545-9	2002	Two alkaloids isolated from the active extract of Guiera senegalensis, harman and tetrahydroharman, showed antimalarial activity (IC(50) lower than 4 microg/mL) and displayed low toxicity against THP1.	Alkaloids	4-13	GLI family zinc finger 2	Homo sapiens	196-200
14989176-0	2003	[Inhibition of liver mitochondrial monoamine oxidase activity by alkaloids isolated from Chelidonium and Macleaya and by their derivative drugs].	Alkaloids	65-74	monoamine oxidase A	Rattus norvegicus	35-52
12506995-5	2002	These three alkaloids inhibited acetylcholinesterase activity at a level comparable to that of physostigmine, but this inhibition was not responsible for the potentiation of NGF-induced neurite outgrowth.	Alkaloids	12-21	acetylcholinesterase	Rattus norvegicus	32-52
12369619-6	2002	The A622 expression patterns were qualitatively similar to those of putrescine N-methyltransferase, the first enzyme in nicotine biosynthesis, suggesting that A622 may function in the metabolism of nicotine or related alkaloids.	Alkaloids	218-227	putrescine N-methyltransferase 1	Nicotiana tabacum	68-98
12369619-6	2002	The A622 expression patterns were qualitatively similar to those of putrescine N-methyltransferase, the first enzyme in nicotine biosynthesis, suggesting that A622 may function in the metabolism of nicotine or related alkaloids.	Alkaloids	218-227	isoflavone reductase homolog A622	Nicotiana tabacum	159-163
12126446-3	2002	Both alkaloids displayed a cytotoxic profile against a panel of HCT-116 colon carcinoma cells indicative of a p53 dependent mechanism.	Alkaloids	5-14	tumor protein p53	Homo sapiens	110-113
12127506-1	2002	Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations.	Alkaloids	27-35	GLI family zinc finger 2	Homo sapiens	191-196
11909625-0	2002	Alkaloid production in Duboisia hybrid hairy root cultures overexpressing the pmt gene.	Alkaloids	0-8	putrescine N-methyltransferase 3	Nicotiana tabacum	78-81
12142990-5	2002	Western blotting analysis reveals that the two alkaloids induce cleavage of the poly(ADP-ribose) polymerase (PARP) and promote the cleavage of a caspase-3 DEVD peptide substrate.	Alkaloids	47-56	poly(ADP-ribose) polymerase 1	Homo sapiens	80-107
12142990-5	2002	Western blotting analysis reveals that the two alkaloids induce cleavage of the poly(ADP-ribose) polymerase (PARP) and promote the cleavage of a caspase-3 DEVD peptide substrate.	Alkaloids	47-56	poly(ADP-ribose) polymerase 1	Homo sapiens	109-113
12142990-5	2002	Western blotting analysis reveals that the two alkaloids induce cleavage of the poly(ADP-ribose) polymerase (PARP) and promote the cleavage of a caspase-3 DEVD peptide substrate.	Alkaloids	47-56	caspase 3	Homo sapiens	145-154
11909625-1	2002	Putrescine:SAM N-methyltransferase (PMT) catalyses the N-methylation of the diamine putrescine to form N-methylputrescine, the first specific precursor of both tropane and pyridine-type alkaloids, which are present together in the roots of Duboisia plants.	Alkaloids	186-195	putrescine N-methyltransferase 3	Nicotiana tabacum	36-39
11890933-7	2002	An epistatic interaction was shown between rad3-e5 and rad52-1 mutants alleles, indicating that excision-resynthesis and strand-break repair may have common steps in the repair of DNA damage induced by these alkaloids.	Alkaloids	208-217	TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3	Saccharomyces cerevisiae S288C	43-47
11966199-0	2002	[Inhibition by various alkaloids of acetylcholinesterase and butyrylcholinesterase from human blood].	Alkaloids	23-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	36-82
11739388-7	2002	Further functional analysis of AtDTX1 protein in KAM3 mutant demonstrated that AtDTX1 serves as an efflux carrier for plant-derived alkaloids, antibiotics, and other toxic compounds.	Alkaloids	132-141	MATE efflux family protein	Arabidopsis thaliana	31-37
11739388-7	2002	Further functional analysis of AtDTX1 protein in KAM3 mutant demonstrated that AtDTX1 serves as an efflux carrier for plant-derived alkaloids, antibiotics, and other toxic compounds.	Alkaloids	132-141	MATE efflux family protein	Arabidopsis thaliana	79-85
11699936-5	2001	The alkaloid veratridine can activate this Na+ influx, causing depolarization and increasing [Ca2+]i in the cells.	Alkaloids	4-12	carbonic anhydrase 2	Rattus norvegicus	94-97
11396162-11	2001	It is concluded that steroidal alkaloids of plant origin act as inhibitors of P-gp-mediated drug transport and multidrug resistance and therefore may serve as chemosensitizers in combination chemotherapy with conventional cytotoxic drugs for treating multidrug resistant cancer.	Alkaloids	31-40	ATP binding cassette subfamily B member 1	Homo sapiens	78-82
11440077-0	2001	Inhibition of calmodulin-dependent calcium-ATPase and phosphodiesterase by various cyclopeptides and peptide alkaloids from the Zizyphus species.	Alkaloids	109-118	calmodulin 1	Homo sapiens	14-24
11469727-1	2001	Cytochrome P450 (P450) enzymes play major roles in the metabolism of drugs, carcinogens, steroids, eicosanoids, alkaloids, pesticides, and other important xenobiotics, as well as chemicals normally endogenous to the body.	Alkaloids	112-121	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-21
11301853-1	2001	Various natural and synthetic compounds including alkaloids, terpenoids and phenolics were tested for inhibition of the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), both of which are crucial in the regulation of immune response and inflammation.	Alkaloids	50-59	intercellular adhesion molecule 1	Mus musculus	147-180
11301853-1	2001	Various natural and synthetic compounds including alkaloids, terpenoids and phenolics were tested for inhibition of the cell surface expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), both of which are crucial in the regulation of immune response and inflammation.	Alkaloids	50-59	intercellular adhesion molecule 1	Mus musculus	182-188
11218731-3	2001	To explore further the mechanism of the suppression for inflammation, we studied the effect of the alkaloids on macrophage tumor necrosis factor (TNF-alpha) production in vitro, since TNF-alpha is recognized as a pivotal cytokine to regulate inflammation.	Alkaloids	99-108	tumor necrosis factor-like	Rattus norvegicus	123-144
11218731-3	2001	To explore further the mechanism of the suppression for inflammation, we studied the effect of the alkaloids on macrophage tumor necrosis factor (TNF-alpha) production in vitro, since TNF-alpha is recognized as a pivotal cytokine to regulate inflammation.	Alkaloids	99-108	tumor necrosis factor	Rattus norvegicus	146-155
11218731-9	2001	From these results, it was concluded that these alkaloids exert inhibitory effects not only on neutrophil apoptosis-inducing protein, calprotectin, but also on macrophage TNF-alpha production.	Alkaloids	48-57	tumor necrosis factor	Rattus norvegicus	171-180
11732315-0	2001	Immunolocalization of alkaloids and X-ray microanalysis of elements in lupin seeds.	Alkaloids	22-31	5'-nucleotidase, cytosolic IIIA	Homo sapiens	71-76
11099695-11	2000	Western blotting analysis revealed that cryptolepine, but not neocryptolepine, induces cleavage of poly(ADP-ribose) polymerase but both alkaloids induce the release of cytochrome c from the mitochondria.	Alkaloids	136-145	cytochrome c, somatic	Homo sapiens	168-180
11732315-1	2001	Immunolocalization of alkaloids in lupin seeds (Lupinus spp.)	Alkaloids	22-31	5'-nucleotidase, cytosolic IIIA	Homo sapiens	35-40
11040335-8	2000	Taken together, the results suggest that suppression of iNOS and cyclooxygenase-2 induction by lipopolysaccharide is responsible for the anti-inflammatory activity of these alkaloids through selective inhibition of the expression of genes, which play important roles in inflammatory signaling pathways.	Alkaloids	173-182	nitric oxide synthase 2, inducible	Mus musculus	56-60
11040335-8	2000	Taken together, the results suggest that suppression of iNOS and cyclooxygenase-2 induction by lipopolysaccharide is responsible for the anti-inflammatory activity of these alkaloids through selective inhibition of the expression of genes, which play important roles in inflammatory signaling pathways.	Alkaloids	173-182	prostaglandin-endoperoxide synthase 2	Mus musculus	65-81
10996241-2	2000	Among the differentially expressed gene products were full-length and partial cDNAs encoding arginine decarboxylase (ADC), ornithine decarboxylase (ODC), and S-adenosylmethionine synthetase (SAMS), enzymes involved in polyamine and alkaloid biosynthesis.	Alkaloids	232-240	S-adenosylmethionine synthase 1	Nicotiana tabacum	158-189
10823674-6	2000	It is thought that the hydroxyl groups of alkaloids, especially a free OH group of 2 at C-6, are important for action on the peripheral vasculature leading to dilatation, and the results indicated that esterification of the hydroxyl group at C-15 with either anisoate, veratroate orp-nitrobenzoate may contribute to enhancement of the activity of the parent alkaloids.	Alkaloids	42-51	complement component 6	Mus musculus	88-91
10953002-6	2000	Expression of MURF establishes a cellular microtubule network that is resistant to microtubule depolymerization induced by alkaloids, cold and calcium.	Alkaloids	123-132	tripartite motif-containing 54	Mus musculus	14-18
10926779-4	2000	The structural features of steroidal alkaloids previously associated with the induction of holoprosencephaly in whole animals are also associated with inhibition of Shh signaling in vitro.	Alkaloids	37-46	sonic hedgehog signaling molecule	Homo sapiens	165-168
11026959-2	2000	Betel nut alkaloids include potent muscarinic cholinomimetics: recent research suggests that these agents may be therapeutic in schizophrenia.	Alkaloids	10-19	NUT midline carcinoma family member 1	Homo sapiens	6-9
10777506-0	2000	Switching agonist/antagonist properties of opiate alkaloids at the delta opioid receptor using mutations based on the structure of the orphanin FQ receptor.	Alkaloids	50-59	opioid related nociceptin receptor 1	Homo sapiens	135-155
10820326-0	2000	Different expression of an S-adenosylmethionine synthetase gene in transgenic tobacco callus modifies alkaloid biosynthesis.	Alkaloids	102-110	S-adenosylmethionine synthase 1	Nicotiana tabacum	27-58
10923842-3	2000	The APCI spectra of alkaloids were predominantly the [M+H]+ ion and the major fragment ion, corresponding to the [M+H-H2O]+ ion or the [M+H-CH3COOH]+ ion, and comparison of the APCI spectra showed that the abundance of fragment ions was significantly higher for C-1 beta-form alkaloids than for C-1 alpha-form alkaloids, and for C-12 beta-form alkaloids than for C-12 alpha-form alkaloids.	Alkaloids	20-29	endogenous retrovirus group K member 1	Homo sapiens	295-304
10823674-6	2000	It is thought that the hydroxyl groups of alkaloids, especially a free OH group of 2 at C-6, are important for action on the peripheral vasculature leading to dilatation, and the results indicated that esterification of the hydroxyl group at C-15 with either anisoate, veratroate orp-nitrobenzoate may contribute to enhancement of the activity of the parent alkaloids.	Alkaloids	358-367	complement component 6	Mus musculus	88-91
10823703-4	2000	The APCI spectra of alkaloids were predominantly the [M+H]+ ion and major fragment ion, corresponding to the [M+H-H2O]+ ion or the [M+H-CH3COOH]+ ion, and comparison of the spectra showed that the abundance of fragment ions was significantly higher for C-1 beta-form alkaloids than for C-1 alpha-form alkaloids.	Alkaloids	20-29	endogenous retrovirus group K member 1	Homo sapiens	286-295
10699570-2	2000	Cytochrome P450 enzymes are known to be involved in the metabolic detoxification of these alkaloids by the desert Drosophila and are consequently responsible for their ability to utilize these substrates.	Alkaloids	90-99	Cytochrome P450-4g1	Drosophila melanogaster	0-15
10781881-3	2000	CYP2A6 is a major contributor to the oxidative metabolism of nicotine and cotinine, and it also contributes, to a larger or smaller extent, to the metabolism of a few pharmaceuticals (e.g. fadrozole), nitrosamines, other carcinogens (e.g. aflatoxin B1) and a number of coumarin-type alkaloids.	Alkaloids	283-292	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
10526129-10	1999	Thus, electrophysiologically these alkaloids seem to inhibit predominantly the excitability of the afferent fibres and, in consequence, neurotransmission between Schaffer collaterals and the CA1 neurons, thereby suppressing the firing of the latter.	Alkaloids	35-44	carbonic anhydrase 1	Rattus norvegicus	191-194
11140610-4	2000	In conclusion, the value of the bimolecular rate constant for selected AChE inhibitors (structural changes that have been hypothesised or natural alkaloids of unknown activity) which possess similar size and rigidity, can be obtained.	Alkaloids	146-155	acetylcholinesterase (Cartwright blood group)	Homo sapiens	71-75
10573080-0	1999	Plant alkaloid tetrandrine and its analog block CD28-costimulated activities of human peripheral blood T cells: potential immunosuppressants in transplantation immunology.	Alkaloids	6-14	CD28 molecule	Homo sapiens	48-52
10417697-8	1999	A comparison of the translations of the nucleotide sequences indicate that the codeinone reductase isoforms are 53% identical to 6"-deoxychalcone synthase from soybean suggesting an evolutionary although not a functional link between enzymes of phenylpropanoid and alkaloid biosynthesis.	Alkaloids	265-273	chalcone reductase CHR1	Glycine max	89-98
10376762-16	1999	Thus, individuals with these FMO3 gene mutations may have defective metabolic activity for many clinically used drugs and dietary plant alkaloids which are oxidized primarily by hepatic FMO3.	Alkaloids	136-145	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	29-33
10217710-0	1999	Oxidized welwitindolinones from terrestrial fischerella spp 3-Hydroxy-N-methylwelwitindolinone C isonitrile (3), 3-hydroxy-N-methylwelwitindolinone C isothiocyanate (4), and the novel cyclic ether N-methylwelwitindolinone D isonitrile (6) are three new alkaloids from two terrestrial Fischerella spp. belonging to the Stigonemataceae.	Alkaloids	254-263	histocompatibility minor 13	Homo sapiens	56-59
10217710-0	1999	Oxidized welwitindolinones from terrestrial fischerella spp 3-Hydroxy-N-methylwelwitindolinone C isonitrile (3), 3-hydroxy-N-methylwelwitindolinone C isothiocyanate (4), and the novel cyclic ether N-methylwelwitindolinone D isonitrile (6) are three new alkaloids from two terrestrial Fischerella spp. belonging to the Stigonemataceae.	Alkaloids	254-263	histocompatibility minor 13	Homo sapiens	297-300
10376762-16	1999	Thus, individuals with these FMO3 gene mutations may have defective metabolic activity for many clinically used drugs and dietary plant alkaloids which are oxidized primarily by hepatic FMO3.	Alkaloids	136-145	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	186-190
9882713-1	1999	We studied the mechanisms by which the plant alkaloid tetrandrine (TTD) inhibits Mac-1-dependent neutrophil adhesion to fibrinogen.	Alkaloids	45-53	integrin subunit alpha M	Homo sapiens	81-86
9547370-6	1998	Furthermore, the orphanin FQ receptor mutant that has the best affinities toward the opioid alkaloids shows, in the presence of GTP and high salt concentration, an affinity-shift profile similar to that of the delta receptor.	Alkaloids	92-101	opioid related nociceptin receptor 1	Homo sapiens	17-37
9766861-7	1998	Solid-phase extraction using Sep-Pak Plus PS-1 was also investigated to clean-up and concentrate alkaloids in blood and urine samples, and showed satisfactory recoveries.	Alkaloids	97-106	presenilin 1	Homo sapiens	42-46
9605562-12	1998	The ergot alkaloids produce AVA constriction for a substantial part via 5-HT1B/1D receptors, but also stimulate unidentified receptors.	Alkaloids	10-19	5-hydroxytryptamine receptor 1B	Sus scrofa	72-78
9547370-8	1998	Our results indicate that 1) several residues in the orphanin FQ receptor are critical to its selectivity against the opiate alkaloids, particularly antagonists; and 2) mutating these residues to those of the opioid receptor at the corresponding position preserves the agonist/antagonist nature of opiate alkaloids as they interact with the mutant receptor.	Alkaloids	125-134	opioid related nociceptin receptor 1	Homo sapiens	53-73
9547370-8	1998	Our results indicate that 1) several residues in the orphanin FQ receptor are critical to its selectivity against the opiate alkaloids, particularly antagonists; and 2) mutating these residues to those of the opioid receptor at the corresponding position preserves the agonist/antagonist nature of opiate alkaloids as they interact with the mutant receptor.	Alkaloids	305-314	opioid related nociceptin receptor 1	Homo sapiens	53-73
9547370-10	1998	These findings may be helpful to medicinal chemists in designing ligands for the orphanin FQ receptor based on the structure of the opiate alkaloids.	Alkaloids	139-148	opioid related nociceptin receptor 1	Homo sapiens	81-101
9401954-7	1997	Inhibition of the binding of the radioligand to the 5-HT1A receptor was observed in every ligand-binding assay performed with the alkaloids; the Ki values for 1, 2 and 3 were in the microM range.	Alkaloids	130-139	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	52-67
9514608-7	1998	Conclusively, it is considered that the hydroxyl groups of alkaloids, especially a free OH group of 2 at C-6, are important for action on the peripheral vasculature leading to dilatation, and these results indicated that esterification of the hydroxyl group at C-15 with either acetate or benzoate may contribute to enhancement of the activity of the parent alkaloids.	Alkaloids	59-68	complement component 6	Mus musculus	105-108
9514608-7	1998	Conclusively, it is considered that the hydroxyl groups of alkaloids, especially a free OH group of 2 at C-6, are important for action on the peripheral vasculature leading to dilatation, and these results indicated that esterification of the hydroxyl group at C-15 with either acetate or benzoate may contribute to enhancement of the activity of the parent alkaloids.	Alkaloids	358-367	complement component 6	Mus musculus	105-108
9467205-2	1998	Alkaloids in betel nut, such as arecoline, may play a contributing role in coronary artery spasm due to parasympathomimetic effects on vessels with abnormal endothelium.	Alkaloids	0-9	NUT midline carcinoma family member 1	Homo sapiens	19-22
9459571-16	1998	The structure/activity relationship shows that alkaloids that activate or block Na+ channels have a benzoyl ester side chain in the C-14 or C-4 positions respectively, whereas the other compounds lack this group.	Alkaloids	47-56	complement component 4B (Chido blood group)	Mus musculus	140-143
9402622-5	1997	Soa allelic variation had a major effect on sensitivity to 0.003-1.0 mM SOA and several concentrations of the bitter-tasting alkaloids brucine, strychnine, and quinine.	Alkaloids	125-134	sucrose octaacetate aversion	Mus musculus	0-3
9189656-12	1997	Argemone oil/alkaloid showed a Type II binding spectra with hepatic cytochrome P-450 (P-450) protein, thereby causing loss of P-450 content and an impairment of phase I and phase II enzymes.	Alkaloids	13-21	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	68-84
9170287-4	1997	With HBr-AcOH, in the case of alkaloids possessing a C-3 hydroxyl group, the methoxymethyl at C-18 formed a tetrahydrofuran, cyclizing at the C-6 position.	Alkaloids	30-39	Bardet-Biedl syndrome 9	Homo sapiens	94-98
9174271-7	1997	These four alkaloids in aqueous solution were recovered almost totally by solid-phase extraction using the styrene polymer resin, Sep-Pak Plus PS-1, and were eluted using a mixture of acetonitrile and hydrochloric acid.	Alkaloids	11-20	presenilin 1	Homo sapiens	143-147
9044851-1	1997	P-glycoprotein expression in lymphoid malignancies has the potential to compromise the efficacy of many therapeutic regimens using anthracyclines, glucocorticoids, and Vinca alkaloids.	Alkaloids	174-183	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
9023182-3	1997	strain AT3 grew with dl-tropic acid, the aromatic component of the alkaloid atropine, as the sole source of carbon and energy.	Alkaloids	67-75	ataxin 3	Homo sapiens	7-10
8797196-4	1996	The present report shows that N-acetylmuramyl-L-alanine-D-isoglutamine (MDP), which elevates the endogenous opiate alkaloids in various brain regions and peripheral tissues, can attenuate the withdrawal syndrome of morphine-addicted rats.	Alkaloids	115-124	dipeptidase 1	Homo sapiens	72-75
8982502-16	1996	These results suggest that whereas the aporphine structure shared by these alkaloids is responsible for their selectively of action for the alpha 1A-adrenoceptor subtype in rat cerebral cortex, defined functional groups, namely the 2-hydroxy function, induces a significant increase in alpha 1A-subtype selectivity and affinity.	Alkaloids	75-84	adrenoceptor alpha 1A	Rattus norvegicus	140-161
9005450-1	1996	The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced.	Alkaloids	24-33	arachidonate 5-lipoxygenase	Mus musculus	131-145
9005450-1	1996	The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced.	Alkaloids	24-33	linoleate 9S-lipoxygenase-4	Glycine max	133-145
9005450-1	1996	The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced.	Alkaloids	24-33	linoleate 9S-lipoxygenase-4	Glycine max	185-197
8891611-5	1996	The introduction of this region into the kappa-opioid receptor is sufficient to impart a delta profile for delta-opioid receptor selective alkaloids such as naltrindole and naltriben.	Alkaloids	139-148	opioid receptor kappa 1	Homo sapiens	41-62
8824940-2	1995	This study is aimed at elucidating the inhibitory effects of two alkaloids, fangchinoline and isotetrandrine, on the induction of the proinflammatory cytokines, interleukin-1 (IL-1), and tumor necrosis factor-alpha (TNF-alpha), by Staphylococcus aureus Cowan 1 (SAC)-stimulated human peripheral blood mononuclear cells.	Alkaloids	65-74	tumor necrosis factor	Homo sapiens	216-225
8720384-7	1996	Due to the interaction between non-peptidic compounds and somatostatin/VIP receptors, these three alkaloids could be promising agents in the research on natural non-peptidic compounds for therapeutical interventions.	Alkaloids	98-107	somatostatin	Homo sapiens	58-70
8720384-7	1996	Due to the interaction between non-peptidic compounds and somatostatin/VIP receptors, these three alkaloids could be promising agents in the research on natural non-peptidic compounds for therapeutical interventions.	Alkaloids	98-107	vasoactive intestinal peptide	Homo sapiens	71-74
8824940-4	1995	Of note was that these two alkaloids appeared to inhibit IL-1 beta production more effectively than IL-1 alpha production.	Alkaloids	27-36	interleukin 1 beta	Homo sapiens	57-66
8824940-5	1995	When the levels of cytokine mRNA were measured by semiquantitative RT-PCR, these alkaloids reduced the levels of the mRNAs of IL-1 beta and TNF-alpha, but not that of beta 2-microglobulin, suggesting that these alkaloids may suppress cytokine transcription selectively.	Alkaloids	81-90	interleukin 1 beta	Homo sapiens	126-135
8824940-5	1995	When the levels of cytokine mRNA were measured by semiquantitative RT-PCR, these alkaloids reduced the levels of the mRNAs of IL-1 beta and TNF-alpha, but not that of beta 2-microglobulin, suggesting that these alkaloids may suppress cytokine transcription selectively.	Alkaloids	81-90	tumor necrosis factor	Homo sapiens	140-149
8824940-5	1995	When the levels of cytokine mRNA were measured by semiquantitative RT-PCR, these alkaloids reduced the levels of the mRNAs of IL-1 beta and TNF-alpha, but not that of beta 2-microglobulin, suggesting that these alkaloids may suppress cytokine transcription selectively.	Alkaloids	211-220	interleukin 1 beta	Homo sapiens	126-135
8824940-5	1995	When the levels of cytokine mRNA were measured by semiquantitative RT-PCR, these alkaloids reduced the levels of the mRNAs of IL-1 beta and TNF-alpha, but not that of beta 2-microglobulin, suggesting that these alkaloids may suppress cytokine transcription selectively.	Alkaloids	211-220	tumor necrosis factor	Homo sapiens	140-149
7490793-1	1995	This study aimed to assess the possibility of a direct effect of betel-nut alkaloids arecoline and arecaidine on cell proliferation and interleukin-6 (IL-6) production by cultured fibroblasts from human normal gingiva, buccal mucosa and oral submucous fibrosis (OSF) buccal mucosa in vitro.	Alkaloids	75-84	interleukin 6	Homo sapiens	136-149
7790902-5	1995	After treatment with alkaloids affecting the cytoskeleton, the morphology of post-synaptic gephyrin clusters was analyzed by confocal immunofluorescence microscopy.	Alkaloids	21-30	gephyrin	Rattus norvegicus	91-99
8047545-2	1994	Both alkaloids relax, concentration dependently, the contractile response elicited by depolarizing solution (KCl 80 mM) or noradrenaline (1 microM).	Alkaloids	5-14	neurogenin 3	Rattus norvegicus	15-20
7997475-5	1994	OB-1 and OB-5 are quaternary base alkaloids known as magnoflorine and phellodendrine, respectively.	Alkaloids	34-43	HOP homeobox	Mus musculus	0-13
8055971-2	1994	The interaction between rat and human liver cytochromes P450 with a series of lysergic acid derivatives and ergopeptide alkaloids was studied by difference visible spectroscopy.	Alkaloids	120-129	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	56-60
8328951-1	1993	Growth of Pseudomonas AT3 on the alkaloid atropine as its sole source of carbon and nitrogen is nitrogen-limited and proceeds by degradation of the tropic acid part of the molecule, with the metabolism of the tropine being limited to the point of release of its nitrogen.	Alkaloids	33-41	ataxin 3	Homo sapiens	22-25
8224110-0	1993	Implication of C-5, C-6 unsaturation as a key structural factor in steroidal alkaloid-induced mammalian teratogenesis.	Alkaloids	77-85	complement C6	Homo sapiens	20-23
8224110-0	1993	Implication of C-5, C-6 unsaturation as a key structural factor in steroidal alkaloid-induced mammalian teratogenesis.	Alkaloids	77-85	complement C5	Homo sapiens	15-18
8099963-2	1993	The present study shows that the alkaloids relax the uterine muscle but with different mechanisms of action.	Alkaloids	33-42	neurogenin 3	Rattus norvegicus	43-48
8099963-3	1993	In Ca(2+)-containing solution all three alkaloids relaxed the uterus previously contracted by KCl or acetylcholine, but in Ca(2+)-free medium only R-apomorphine was able to relax oxytocin-induced contraction.	Alkaloids	40-49	neurogenin 3	Rattus norvegicus	50-55
1358068-0	1992	P-glycoprotein possesses a 1,4-dihydropyridine-selective drug acceptor site which is alloserically coupled to a vinca-alkaloid-selective binding site.	Alkaloids	118-126	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
1635552-1	1992	The protein kinase C (PKC) inhibitor staurosporine, a member of the K252a family of fungal alkaloids that are known as protein kinase inhibitors, induces neurite outgrowth in pheochromocytoma PC12 cells.	Alkaloids	91-100	protein kinase C, gamma	Rattus norvegicus	4-20
1632837-6	1992	These data suggest that these alkaloids suppress the receptor-mediated phospholipase A2 activation through, at least in part, uncoupling of a GTP-binding protein from the enzyme, rather than by affecting the enzyme directly.	Alkaloids	30-39	phospholipase A2 group IB	Rattus norvegicus	71-87
1632837-6	1992	These data suggest that these alkaloids suppress the receptor-mediated phospholipase A2 activation through, at least in part, uncoupling of a GTP-binding protein from the enzyme, rather than by affecting the enzyme directly.	Alkaloids	30-39	RAS like proto-oncogene B	Rattus norvegicus	142-161
1635552-1	1992	The protein kinase C (PKC) inhibitor staurosporine, a member of the K252a family of fungal alkaloids that are known as protein kinase inhibitors, induces neurite outgrowth in pheochromocytoma PC12 cells.	Alkaloids	91-100	protein kinase C, gamma	Rattus norvegicus	22-25
1730056-2	1992	The effect of the alkaloids on the nonenzymatic and the eEF-1-dependent Phe-tRNA(Phe) binding to poly(U)-programmed 80S ribosomes, diphenylalanine synthesis accompanying nonenzymatic Phe-tRNA(Phe) binding and acetylphenylalanyl-puromycin formation was examined.	Alkaloids	18-27	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	56-61
1659822-1	1991	Tyrosinase (EC 1.14.18.1)/O2, ceruloplasmin (human type X)/O2, and peroxidase (EC 1.11.1.7)/H2O2 oxidized the endogenous central nervous system alkaloid salsolinol (SAL) at physiological pH.	Alkaloids	144-152	tyrosinase	Homo sapiens	0-10
1681887-1	1991	Resistance to multiple antitumour drugs, mostly antibiotics or alkaloids, has been associated with a cellular plasma membrane P-glycoprotein (Pgp), causing energy-dependent transport of drugs out of cells.	Alkaloids	63-72	ATP binding cassette subfamily B member 1	Homo sapiens	126-140
1681887-1	1991	Resistance to multiple antitumour drugs, mostly antibiotics or alkaloids, has been associated with a cellular plasma membrane P-glycoprotein (Pgp), causing energy-dependent transport of drugs out of cells.	Alkaloids	63-72	ATP binding cassette subfamily B member 1	Homo sapiens	142-145
1899790-3	1991	All these four alkaloids suppressed arachidonic acid liberation in response to collagen or thrombin, but not diacylglycerol formation and increase in cytoplasmic Ca2+ concentration in response to thrombin or arachidonic acid.	Alkaloids	15-24	prothrombin	Oryctolagus cuniculus	91-99
2032020-2	1991	A C18 column was used to separate scopolamine from the additional alkaloids and other biological material present in the vegetal extract.	Alkaloids	66-75	Bardet-Biedl syndrome 9	Homo sapiens	2-5
1963807-13	1990	The alkaloid veratridine, which activates Na+ channels and also causes influx of Ca2+ induced a transient rise of cyclic GMP levels in the neuronal cell line.	Alkaloids	4-12	5'-nucleotidase, cytosolic II	Mus musculus	121-124
2037868-5	1991	A fluorimetric analysis of the binding of the three alkaloids show that the dissociation constants (Kd) for malate dehydrogenase are 2.8 microM (berberine), 46 microM (papaverine) and 86 microM (isoquinoline); the corresponding values for lactate dehydrogenase are 3.1 microM, 52 microM and 114 microM.	Alkaloids	52-61	malic enzyme 2	Homo sapiens	108-128
2107186-2	1990	The alkaloids in the ant"s unique venom also produce substantial morbidity due to local reactions, both toxin- and IgE-mediated.	Alkaloids	4-13	solute carrier family 25 member 6	Homo sapiens	21-24
2157445-5	1990	These and other observations indicated that these alkaloids inhibited the active oxygen generation by way of stabilizing plasma membrane and inhibiting PKC and NADPH oxidase activation.	Alkaloids	50-59	Prkca	Cavia porcellus	152-155
34520895-7	2022	Coefficient of determination of prediction (R2p) and root mean square errors of prediction (RMSEP) obtained were 0.8562 and 0.3911; 0.6917 and 0.0117, for ethanol-soluble extractives and total alkaloid content, respectively.	Alkaloids	193-201	ribonucleotide reductase regulatory subunit M2	Homo sapiens	44-47
33972592-2	2021	As such, naturally occurring alkaloids that regulate nAChR activity have gained interest for understanding and potentially improving memory function.	Alkaloids	29-38	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	53-58
33972592-7	2021	Thus, nAChR-activating alkaloids may possess distinct procognitive properties in rodents, depending on the memory types examined.	Alkaloids	23-32	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	6-11
32796875-5	2020	In this study, combining in silico (pharmacophore-based virtual screening and docking) and pharmacological (in vitro binding and functional assays, and behavioral tests) approaches, we report on the discovery of two naturally occurring plant alkaloids, corydine and corydaline, as new MOR agonists that produce antinociceptive effects in mice after subcutaneous administration via a MOR-dependent mechanism.	Alkaloids	242-251	opioid receptor, mu 1	Mus musculus	285-288
32796875-5	2020	In this study, combining in silico (pharmacophore-based virtual screening and docking) and pharmacological (in vitro binding and functional assays, and behavioral tests) approaches, we report on the discovery of two naturally occurring plant alkaloids, corydine and corydaline, as new MOR agonists that produce antinociceptive effects in mice after subcutaneous administration via a MOR-dependent mechanism.	Alkaloids	242-251	opioid receptor, mu 1	Mus musculus	383-386
34626776-9	2022	RESULTS: Our study revealed alkaloids, flavonoids, and polysaccharides in mulberry leaf could increase the levels of PK, HK, and ALT/GPT, and decrease the levels of TG and T-Cho significantly, and regulate glucose, amino acid, and lipid metabolism.	Alkaloids	28-37	glutamic pyruvic transaminase, soluble	Mus musculus	129-132
34626776-9	2022	RESULTS: Our study revealed alkaloids, flavonoids, and polysaccharides in mulberry leaf could increase the levels of PK, HK, and ALT/GPT, and decrease the levels of TG and T-Cho significantly, and regulate glucose, amino acid, and lipid metabolism.	Alkaloids	28-37	glutamic pyruvic transaminase, soluble	Mus musculus	133-136
34256299-2	2021	Xenobiotics as CYP2D6 substrates include a whole range of pharmaceuticals, pesticides and plant alkaloids to cite but a few.	Alkaloids	96-105	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	15-21
34800750-5	2021	For the purposes of this article, the influence of CYP3A inducer and inhibitor on cytotoxicity of EF and metabolism in L02 cells of five alkaloids related to toxicity of EF were evaluated.	Alkaloids	137-146	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	51-56
34735909-4	2021	PURPOSE: To further identify bioactive alkaloids targeting LOX/COX pathways.	Alkaloids	39-48	lysyl oxidase	Rattus norvegicus	59-62
34735909-5	2021	METHODS: An affinity-ultrafiltration mass spectrometry approach was employed to screen dual-target LOX-5/COX-2 ligands from alkaloid extract.	Alkaloids	124-132	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	105-110
34735909-7	2021	To understand the molecular mechanisms underlying the effects of bioactive alkaloids, the expression levels of LOX-5 and COX-2 in BPH model rats were investigated at both protein and mRNA levels.	Alkaloids	75-84	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	121-126
34735909-8	2021	The LOX-5/COX-2 enzymes activity experiments and molecular docking analysis were performed to fully evaluate the interactions between bioactive alkaloids and LOX-5/COX-2.	Alkaloids	144-153	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	10-15
34735909-8	2021	The LOX-5/COX-2 enzymes activity experiments and molecular docking analysis were performed to fully evaluate the interactions between bioactive alkaloids and LOX-5/COX-2.	Alkaloids	144-153	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	164-169
34735909-9	2021	RESULTS: After comprehensive analysis, the results showed that bioactive alkaloids could suppress the expression of LOX-5 and COX-2 simultaneously to exert an anti-inflammatory effect on the progression of BPH.	Alkaloids	73-82	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	126-131
34735909-12	2021	CONCLUSION: This study is the first to explore the inhibitory effects of bioactive alkaloids from CP on LOX-5 and COX-2 activities in BPH rats.	Alkaloids	83-92	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	114-119
34695457-4	2021	We have analyzed all known pharmacological activities of alpha TM and TD, and the corresponding molecular targets and pathways impacted by these two steroidal alkaloids.	Alkaloids	159-168	ATM serine/threonine kinase	Homo sapiens	57-72
34620048-5	2022	We selected the four currently most popular pathways for discussion and introduced the molecular mechanisms mediated by alkaloids in different signaling pathways, including the NF-kB signaling pathway, PI3K/AKT signaling pathway, MAPK signaling pathway, and P53 signaling pathway.	Alkaloids	120-129	AKT serine/threonine kinase 1	Homo sapiens	207-210
34664067-8	2021	UHPLC-fourier-transform mass spectrometry detection results revealed that five alkaloids showed obvious AChE inhibitory activities including coptisin, epiberberine, jatrorrhizine, berberine and palmatine.	Alkaloids	79-88	acetylcholinesterase (Cartwright blood group)	Homo sapiens	104-108
34620048-5	2022	We selected the four currently most popular pathways for discussion and introduced the molecular mechanisms mediated by alkaloids in different signaling pathways, including the NF-kB signaling pathway, PI3K/AKT signaling pathway, MAPK signaling pathway, and P53 signaling pathway.	Alkaloids	120-129	tumor protein p53	Homo sapiens	258-261
34269666-11	2021	In this review, the main natural compounds that are derived from alkaloids, flavonoids, terpene, and polyphenols as promising TNF-alpha inhibitors will be discussed.	Alkaloids	65-74	tumor necrosis factor	Homo sapiens	126-135
34107799-1	2021	The current research used a virtual screening method to study 57 isolated phytochemicals (alkaloids, phytosterols, and flavonoids) against the SARS-CoV-2 main protease (Mpro).	Alkaloids	90-99	main protease	None	154-167
34107799-1	2021	The current research used a virtual screening method to study 57 isolated phytochemicals (alkaloids, phytosterols, and flavonoids) against the SARS-CoV-2 main protease (Mpro).	Alkaloids	90-99	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	169-173
34063022-0	2021	Effects of Sponge-Derived Alkaloids on Activities of the Bacterial alpha-D-Galactosidase and Human Cancer Cell alpha-N-Acetylgalactosaminidase.	Alkaloids	26-35	alpha-N-acetylgalactosaminidase	Homo sapiens	111-142
35398497-12	2022	Seven phytochemical compounds were detected in the serum and their contents in AR/PCC varied dramatically with different proportions, including 1 xanthone glycoside and 6 alkaloids.	Alkaloids	171-180	ferredoxin reductase	Rattus norvegicus	79-85
35452774-9	2022	Anti-inflammatory test indicated that steroidal alkaloids could decrease the expression of cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells at a concentration of 5.0 mug/ml in vitro, comparable to DXM.	Alkaloids	48-57	prostaglandin-endoperoxide synthase 2	Mus musculus	91-107
35452774-9	2022	Anti-inflammatory test indicated that steroidal alkaloids could decrease the expression of cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells at a concentration of 5.0 mug/ml in vitro, comparable to DXM.	Alkaloids	48-57	prostaglandin-endoperoxide synthase 2	Mus musculus	109-114
35452774-9	2022	Anti-inflammatory test indicated that steroidal alkaloids could decrease the expression of cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells at a concentration of 5.0 mug/ml in vitro, comparable to DXM.	Alkaloids	48-57	interleukin 1 beta	Mus musculus	117-134
35452774-9	2022	Anti-inflammatory test indicated that steroidal alkaloids could decrease the expression of cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells at a concentration of 5.0 mug/ml in vitro, comparable to DXM.	Alkaloids	48-57	interleukin 1 alpha	Mus musculus	136-144
35452774-9	2022	Anti-inflammatory test indicated that steroidal alkaloids could decrease the expression of cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells at a concentration of 5.0 mug/ml in vitro, comparable to DXM.	Alkaloids	48-57	tumor necrosis factor	Mus musculus	151-178
35452774-9	2022	Anti-inflammatory test indicated that steroidal alkaloids could decrease the expression of cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells at a concentration of 5.0 mug/ml in vitro, comparable to DXM.	Alkaloids	48-57	tumor necrosis factor	Mus musculus	180-189
35623174-0	2022	Corydalis saxicola Bunting Total Alkaloids ameliorate diet-induced non-alcoholic steatohepatitis by regulating hepatic PI3K/Akt and TLR4/NF-kappaB pathways in mice.	Alkaloids	33-42	thymoma viral proto-oncogene 1	Mus musculus	124-127
35623174-0	2022	Corydalis saxicola Bunting Total Alkaloids ameliorate diet-induced non-alcoholic steatohepatitis by regulating hepatic PI3K/Akt and TLR4/NF-kappaB pathways in mice.	Alkaloids	33-42	toll-like receptor 4	Mus musculus	132-136
35623174-0	2022	Corydalis saxicola Bunting Total Alkaloids ameliorate diet-induced non-alcoholic steatohepatitis by regulating hepatic PI3K/Akt and TLR4/NF-kappaB pathways in mice.	Alkaloids	33-42	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	137-146
35357518-6	2022	The findings of this review confirm that polyphenols, flavonoids, alkaloids, terpenoids, and anthocyanins are capable of modulating FOXO1 and associated signaling pathways, and they are potential therapeutic agents for NAFLD and related complications.	Alkaloids	66-75	forkhead box O1	Homo sapiens	132-137
35566380-3	2022	The effect of these alkaloids on the multidrug efflux pump ABCB1 (MDR1/P-Glycoprotein) and their antiproliferative properties were studied.	Alkaloids	20-29	ATP binding cassette subfamily B member 1A	Rattus norvegicus	59-64
35544614-4	2022	In the procurement of Wnt/beta-catenin inhibitors from natural alkaloids, 1 was found to exhibit activity against the Wnt/beta-catenin-response reporter gene.	Alkaloids	63-72	catenin beta 1	Homo sapiens	26-38
35544324-2	2022	Similar to other ingredients, TPA may be affected by storing or processing of food, often associated with decreased levels of the parent alkaloids.	Alkaloids	137-146	plasminogen activator, tissue type	Homo sapiens	30-33
35577799-1	2022	A tetrasubstituted carbon atom connected by three sp3 or sp2-carbons with single nitrogen, i.e., the alpha-tertiary amine (ATA) functional group, is an essential structure of diverse naturally occurring alkaloids and pharmaceuticals.	Alkaloids	203-212	Sp3 transcription factor	Homo sapiens	50-53
35577799-1	2022	A tetrasubstituted carbon atom connected by three sp3 or sp2-carbons with single nitrogen, i.e., the alpha-tertiary amine (ATA) functional group, is an essential structure of diverse naturally occurring alkaloids and pharmaceuticals.	Alkaloids	203-212	Sp2 transcription factor	Homo sapiens	57-60
35620478-5	2022	In this context, the present work explored Jadwar (Delphinium denudatum)-derived natural alkaloids as potential inhibitors against Mpro of SARS-CoV-2 by employing a combination of molecular docking and molecular dynamic simulation-based methods.	Alkaloids	89-98	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	131-135
35620478-6	2022	Molecular docking and interaction profile analysis revealed strong binding on the Mpro functional domain with four natural alkaloids viz.	Alkaloids	123-132	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	82-86
35566380-3	2022	The effect of these alkaloids on the multidrug efflux pump ABCB1 (MDR1/P-Glycoprotein) and their antiproliferative properties were studied.	Alkaloids	20-29	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	66-70
35566380-3	2022	The effect of these alkaloids on the multidrug efflux pump ABCB1 (MDR1/P-Glycoprotein) and their antiproliferative properties were studied.	Alkaloids	20-29	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	71-85
35566380-6	2022	Altogether, this work has provided new insights into the biological effects of these alkaloids on the rat Mdr1b P-gp efflux mechanism and would be beneficial in the design of potent P-gp inhibitors.	Alkaloids	85-94	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	106-111
35566380-6	2022	Altogether, this work has provided new insights into the biological effects of these alkaloids on the rat Mdr1b P-gp efflux mechanism and would be beneficial in the design of potent P-gp inhibitors.	Alkaloids	85-94	phosphoglycolate phosphatase	Rattus norvegicus	112-116
35393990-1	2022	This research describes a nanomaterial-assisted thread-based isotachophoresis (TB-ITP) setup for the clean-up, preconcentration, and trapping of alkaloids (coptisine, berberine, and palmatine) in biological fluids, followed by their on-thread desorption electrospray ionization mass spectrometry (DESI-MS) determination.	Alkaloids	145-154	desumoylating isopeptidase 2	Homo sapiens	297-301
35385268-9	2022	The mechanism of the different effects of alkaloids on inhibiting acetylcholinesterase activity was explored via molecular docking and kinetic simulation.	Alkaloids	42-51	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-86
35586062-1	2022	Alkaloid Suppresses NLRP3-Mediated Pyroptosis to Alleviate LPS-Induced Neurotoxicity.	Alkaloids	0-8	NLR family, pyrin domain containing 3	Mus musculus	20-25
35341731-0	2022	Natural alkaloids targeting EGFR in non-small cell lung cancer: Molecular docking and ADMET predictions.	Alkaloids	8-17	epidermal growth factor receptor	Homo sapiens	28-32
35341731-4	2022	In this study, in silico molecular docking was performed using AutoDock Vina for thirty-one alkaloids against epidermal growth factor receptor (EGFR).	Alkaloids	92-101	epidermal growth factor receptor	Homo sapiens	110-142
35341731-4	2022	In this study, in silico molecular docking was performed using AutoDock Vina for thirty-one alkaloids against epidermal growth factor receptor (EGFR).	Alkaloids	92-101	epidermal growth factor receptor	Homo sapiens	144-148
35001637-7	2022	Many kinds of natural products promote white adipose tissue browning, such as alkaloids, flavonoids, terpenoids, and long-chain fatty acids, which can also ameliorate metabolic disorders including obesity, insulin resistance and diabetes.	Alkaloids	78-87	insulin	Homo sapiens	206-213
35230092-1	2022	Intramolecular phenol coupling reactions of alkaloids can lead to active metabolites catalyzed by the mammalian cytochrome P450 enzyme (P450); however, the mechanistic knowledge of such an "unusual" process is lacking.	Alkaloids	44-53	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	112-127
35230092-1	2022	Intramolecular phenol coupling reactions of alkaloids can lead to active metabolites catalyzed by the mammalian cytochrome P450 enzyme (P450); however, the mechanistic knowledge of such an "unusual" process is lacking.	Alkaloids	44-53	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	135-141
35335376-3	2022	As an important source of cholinesterase inhibitors, alkaloids in natural products have high potential value in terms of exerting pharmacological activities.	Alkaloids	53-62	butyrylcholinesterase	Homo sapiens	26-40
35209140-7	2022	The alkaloid exhibits an anti-inflammatory property by stalling the expression of cyclooxygenase 2 (COX-2) and prostaglandin E2.	Alkaloids	4-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	82-98
35310033-5	2022	In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity.	Alkaloids	78-87	prostaglandin-endoperoxide synthase 2	Homo sapiens	230-246
35310033-5	2022	In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity.	Alkaloids	78-87	prostaglandin-endoperoxide synthase 2	Homo sapiens	248-253
35310033-5	2022	In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity.	Alkaloids	78-87	acetylcholinesterase (Cartwright blood group)	Homo sapiens	296-316
35310033-5	2022	In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity.	Alkaloids	78-87	acetylcholinesterase (Cartwright blood group)	Homo sapiens	318-322
35310033-5	2022	In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity.	Alkaloids	157-166	prostaglandin-endoperoxide synthase 2	Homo sapiens	230-246
35310033-5	2022	In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity.	Alkaloids	157-166	prostaglandin-endoperoxide synthase 2	Homo sapiens	248-253
35310033-5	2022	In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity.	Alkaloids	157-166	acetylcholinesterase (Cartwright blood group)	Homo sapiens	296-316
35310033-5	2022	In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity.	Alkaloids	157-166	acetylcholinesterase (Cartwright blood group)	Homo sapiens	318-322
35268836-2	2022	Key transformations include an ACE-Cl mediated late-stage N(4)-demethylation and an anhydrous acid-mediated intramolecular quaternary hemiaminal formation between a tertiary amine and an aldehyde function to allow efficient access to several biologically important alkaloids from this group.	Alkaloids	265-274	angiotensin I converting enzyme	Homo sapiens	31-34
35253621-0	2022	An integrated computational approach to screening of alkaloids inhibitors of TBX3 in breast cancer cell lines.	Alkaloids	53-62	T-box transcription factor 3	Homo sapiens	77-81
35253621-8	2022	The molecular mechanics-generalized born surface area (MM-GBSA) and molecular dynamics (MD) simulation showed that Jervine along with Diflomotecan formed the stable complexes with TBX3 which makes it obvious that these two alkaloids can be introduced into the drug development pipeline and used as a new leader to develop new effective drugs against breast cancer.Communicated by Ramaswamy H. Sarma.	Alkaloids	223-232	T-box transcription factor 3	Homo sapiens	180-184
35092909-0	2022	Aconiti Lateralis Radix Praeparata lipid-soluble alkaloids alleviates IL-1beta-induced inflammation of human fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting NF-kappaB and MAPKs signaling pathways and inducing apoptosis.	Alkaloids	49-58	interleukin 1 alpha	Homo sapiens	70-78
35092909-0	2022	Aconiti Lateralis Radix Praeparata lipid-soluble alkaloids alleviates IL-1beta-induced inflammation of human fibroblast-like synoviocytes in rheumatoid arthritis by inhibiting NF-kappaB and MAPKs signaling pathways and inducing apoptosis.	Alkaloids	49-58	nuclear factor kappa B subunit 1	Homo sapiens	176-185
35104489-7	2022	Nutraceuticals belonging to the chemical category polyphenols, alkaloids, terpenoids, flavonoids, tannins have the potential to combat the NF-kappaB pathway.	Alkaloids	63-72	nuclear factor kappa B subunit 1	Homo sapiens	139-148
35209140-7	2022	The alkaloid exhibits an anti-inflammatory property by stalling the expression of cyclooxygenase 2 (COX-2) and prostaglandin E2.	Alkaloids	4-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	100-105
35207127-2	2022	In plants, alkaloids, phytohormones, ion chelators, and flavonoids have been reported to be the substrates of MATE transporters.	Alkaloids	11-20	aluminum-activated citrate transporter	Glycine max	110-114
35058003-1	2022	A thread-based isotachophoresis method coupled with desorption electrospray ionization mass spectrometry (TB-ITP-DESI-MS) was developed and applied for clean-up, preconcentration, and determination of alkaloids in biological fluids.	Alkaloids	201-210	desumoylating isopeptidase 2	Homo sapiens	113-117
35127798-0	2021	Two Alkaloids From Delphinium brunonianum Royle, Their Anti-inflammatory and Anti-oxidative Stress Activity via NF-kappaB Signaling Pathway.	Alkaloids	4-13	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	112-121
35049930-5	2022	As the major clinical indications (CI) of AD are extracellular plaques formed by beta-amyloid (Abeta) protein, intracellular neurofibrillary tangles (NFTs) formed by hyper phosphorylated tau-protein, uncommon inflammatory response and neuron apoptosis and death caused by oxidative stress, alkaloids that may decrease CI, might be used against AD.	Alkaloids	290-299	microtubule associated protein tau	Homo sapiens	187-190
35068466-3	2022	alkaloids (DNLA) are effective in ameliorating cognitive deficit in SAMP8, AbetaPP/PS1, and LPS-induced AD animal models, and prevented Abeta-induced synaptic degeneration in cultured hippocampal neurons.	Alkaloids	0-9	amyloid beta precursor protein	Rattus norvegicus	136-141
2540272-3	1989	Only strychnine and structurally related alkaloids or derivatives were able to inhibit [3H]strychnine binding to the IgG.	Alkaloids	41-50	immunoglobulin heavy variable V1-62	Mus musculus	117-120
2558711-1	1989	Castanospermine, a plant alkaloid that inhibits the glycoprotein processing enzyme glucosidase I, has been used to inhibit N-linked oligosaccharide modification, resulting in the production of glycoproteins having Glc3Man7-9(GlcNAc)2 oligosaccharides.	Alkaloids	25-33	mannosyl-oligosaccharide glucosidase	Homo sapiens	83-96
2539275-0	1989	Suppression of human monocyte interleukin 1 production by the plant alkaloid tetrandrine.	Alkaloids	68-76	interleukin 1 alpha	Homo sapiens	30-43
3037334-2	1987	Mutations in CRY1 can confer resistance to the alkaloid cryptopleurine, an inhibitor of the elongation step of translation.	Alkaloids	47-55	ribosomal 40S subunit protein S14A	Saccharomyces cerevisiae S288C	13-17
2500331-1	1989	The GH receptor in adipocytes is a glycoprotein that has a half-life of less than 1 h. After 2 h of treatment with the alkaloid swainsonine, which interferes with carbohydrate processing, virtually all of the GH receptors on the surface of adipocytes are replaced with receptors whose carbohydrate side-chains are incomplete.	Alkaloids	119-127	growth hormone receptor	Rattus norvegicus	4-15
2844393-1	1988	The alkaloid derivative 4"-demethylepipodophyllotoxin 9-(4,6-O-ethylidene)-beta-D-glucopyranoside (etoposide, VP-16) is believed to exert cytotoxicity by causing double-stranded DNA breaks through interruption of the breaking-resealing reaction of topoisomerase II (topo II).	Alkaloids	4-12	host cell factor C1	Homo sapiens	110-115
3135550-5	1988	Treatment with another plant alkaloid, castanospermine, which inhibits glucosidase I and causes the accumulation of glucose-containing high-mannose structures, has the opposite effect and inhibits the proliferative response of the T cell to antigen.	Alkaloids	29-37	mannosyl-oligosaccharide glucosidase	Mus musculus	71-84
3268426-2	1988	The venom of the European Ant Monomorium is composed of five alkaloids: three 2.5 transdialkylpyrrolidines and two 2.5 transdialkylpyrrolines.	Alkaloids	61-70	solute carrier family 25 member 6	Homo sapiens	26-29
2963623-1	1987	Ca2+-stimulated Mg2+-dependent ATPase (Ca2+ + Mg2+-ATPase) stimulated by calmodulin, by partial proteolysis or by oleic acid in erythrocyte membranes was inhibited by various derivatives of the naturally occurring alkaloid berbamine.	Alkaloids	214-222	calmodulin 1	Homo sapiens	73-83
3012081-10	1986	The mu 1 site represents a high affinity binding site for both opioid peptides and opioid alkaloids.	Alkaloids	90-99	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	4-8
11539094-3	1986	This led us to undertake experiments to permit discrimination between ADC and ODC as enzymatic sources of putrescine destined for alkaloids.	Alkaloids	130-139	arginine decarboxylase	Nicotiana tabacum	70-73
11539094-3	1986	This led us to undertake experiments to permit discrimination between ADC and ODC as enzymatic sources of putrescine destined for alkaloids.	Alkaloids	130-139	ornithine decarboxylase	Nicotiana tabacum	78-81
11539094-4	1986	Two kinds of evidence presented here support a major role for ADC in the generation of putrescine going into alkaloids:  (a) A specific "suicide inhibitor" of ADC effectively inhibits the biosynthesis of nicotine and nornicotine in tobacco callus, while the analogous inhibitor of ODC is less effective, and (b) the flow of 14C from uniformly labelled arginine into nicotine is much more efficient than that from ornithine.	Alkaloids	109-118	arginine decarboxylase	Nicotiana tabacum	62-65
11539094-4	1986	Two kinds of evidence presented here support a major role for ADC in the generation of putrescine going into alkaloids:  (a) A specific "suicide inhibitor" of ADC effectively inhibits the biosynthesis of nicotine and nornicotine in tobacco callus, while the analogous inhibitor of ODC is less effective, and (b) the flow of 14C from uniformly labelled arginine into nicotine is much more efficient than that from ornithine.	Alkaloids	109-118	arginine decarboxylase	Nicotiana tabacum	159-162
2988452-0	1985	Aldose reductase inhibitors: flavonoids, alkaloids, acetophenones, benzophenones, and spirohydantoins of chroman.	Alkaloids	41-50	aldo-keto reductase family 1 member B1	Oryctolagus cuniculus	0-16
6324242-0	1984	Effects of catecholamine-related mammalian alkaloids on spontaneous and vasopressin-induced behavior in mice.	Alkaloids	43-52	arginine vasopressin	Homo sapiens	72-83
7085626-4	1982	These alkaloids may alter monoamine metabolism in mammals by inhibiting dihydropteridine reductase.	Alkaloids	6-15	quinoid dihydropteridine reductase	Homo sapiens	72-98
6141281-4	1984	Other peptides and alkaloids tested for ability to block the neurotensin contractures included the enkephalins, beta-endorphin, normorphine and the ketocyclazocines; all these opioids inhibited in a dose-dependent fashion the neuronal component of the excitatory effect of neurotensin.	Alkaloids	19-28	neurotensin/neuromedin N	Cavia porcellus	61-72
16867724-1	1984	A rapid assay is described for the simultaneous determination of emetine and cephaeline in ipecacuanha and its preparations, based upon the different fluorescence intensities of the alkaloids at pH 1 and pH 12.	Alkaloids	182-191	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	195-199
16867724-3	1984	Concentrations of the individual alkaloids are calculated using two simultaneous equations derived from the experimentally determined coefficients of fluorescence of solutions (1 mug/ml) of emetine and cephaeline at pH 1 and pH 12.	Alkaloids	33-42	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	216-220
6662505-0	1983	[Peptide alkaloids from Discaria febrifuga Mart].	Alkaloids	9-18	septin 4	Homo sapiens	43-47
6303602-4	1983	A direct influence on T-cell protein synthesis by either colchicine or lumicolchicine is likely, as greater than or equal to 10(-6) M concentrations of alkaloid identically inhibited [3H]leucine incorporation and Fc mu-receptor expression by T cells without inhibiting their alpha-methyl isobutyric acid transport.	Alkaloids	152-160	Fc mu receptor	Homo sapiens	213-227
6258678-1	1980	1 Morphine, methadone, levorphanol, pethidine, etonitazene and related morphine-like alkaloids produced an increase in the electrically-evoked muscular contraction of the rat vas deferens.	Alkaloids	85-94	arginine vasopressin	Rattus norvegicus	175-178
6830260-3	1983	The structural requirements for the interaction of alkaloids with glutamate dehydrogenase and alcohol dehydrogenase are different.	Alkaloids	51-60	aldo-keto reductase family 1 member A1	Bos taurus	94-115
6296876-1	1982	The opioid peptides, beta-endorphin and the enkephalins, exhibit binding to brain tissue that is stereospecific, of high affinity, and saturable; from comparisons of the pharmacological potencies of a number of alkaloids with their abilities to displace peptide binding, it is concluded that peptide binding is probably relevant to pharmacological response for beta-endorphin, but not necessarily for enkephalins.	Alkaloids	211-220	proopiomelanocortin	Homo sapiens	21-35
6166344-4	1981	In contrast, the release of cortical [(3)H]-noradrenaline and [(14)C]-acetylcholine caused by the alkaloid was greatly diminished in Ca-free medium.5 The veratridine but not the K-evoked release of [(3)H]-GABA was abolished when the external Na concentration [Na](o) was reduced to zero and by tetrodotoxin (TTX) (0.2 muM).	Alkaloids	98-106	latexin	Homo sapiens	318-321
6768879-0	1980	Inhibition of human pregnancy plasma diamine oxidase with alkaloids of Argemone mexicana--berberine and sanguinarine.	Alkaloids	58-67	amine oxidase copper containing 1	Homo sapiens	37-52
6254040-4	1980	The antitubulin alkaloids colchicine and vinblastine, but not the antimicrofilament compound cytochalasin B, increased the maximal hormone-induced formation of cyclic AMP in nucleated MGI+D+ cells but not in the MGI-D- cells.	Alkaloids	16-25	CMS1A1	Homo sapiens	184-187
6254040-4	1980	The antitubulin alkaloids colchicine and vinblastine, but not the antimicrofilament compound cytochalasin B, increased the maximal hormone-induced formation of cyclic AMP in nucleated MGI+D+ cells but not in the MGI-D- cells.	Alkaloids	16-25	CMS1A1	Homo sapiens	212-215
6254040-5	1980	These alkaloids also inhibited the development of desensitization to l-isoproterenol and prostaglandin E1 in enucleated MGI+D+ cells.	Alkaloids	6-15	CMS1A1	Homo sapiens	120-123
118858-7	1979	The interface between plants and insects is enormous, and therefore it appears probable that cytochrome P-450 will one day be shown to be important in the conversion/utilization of other plant secondary substances, e.g., synthesis of cholesterol from phytosterols, and sex pheromones from olefins, terpenes, and alkaloids.	Alkaloids	312-321	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	93-109
698301-2	1978	Butyrylcholine esterase found to increase the hydrolysis rate of all the alkaloid esters studied with the increase of acyl radical either to valerates (for ephedrine and pseudo-ephedrine derivatives), or to butyrates (for the rest alkaloids) and then it did not considerably change under further elongation of carbon chain up to valerate.	Alkaloids	231-240	butyrylcholinesterase	Homo sapiens	0-23
347462-5	1978	The isolation of pharmacologically useful alkaloids started in 1906 with the discovery of ergotoxine and its adrenolytic activity by Barger, Carr and Dale.	Alkaloids	42-51	arrestin 3	Homo sapiens	141-145
918165-0	1977	[Alkaloids of Ammonaceae XVII: Alkaloids of Enantia polycarpa Engl.	Alkaloids	1-10	exo/endonuclease G	Homo sapiens	62-66
918165-0	1977	[Alkaloids of Ammonaceae XVII: Alkaloids of Enantia polycarpa Engl.	Alkaloids	31-40	exo/endonuclease G	Homo sapiens	62-66
925910-1	1977	TLC analysis of extracts of Pilosocereus maxonii (Rose) Byles and Rowley detected six identifiable alkaloids.	Alkaloids	99-108	lipocalin 1	Homo sapiens	0-3
1206408-0	1975	Inhibition of acetylcholinesterase by bicuculline and related alkaloids.	Alkaloids	62-71	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
1410-2	1976	AG 1-X4 and cellex D. The chromatographic behaviour of 48 alkaloids has been studied on Bio-Rad AG 1-X4, Cellex D and microcrystalline cellulose, eluting with solutions of different pH but constant ionic strength (0.5).	Alkaloids	58-67	NBPF member 10	Homo sapiens	0-4
1410-4	1976	The influence of pH on the chromatographic behaviour of alkaloids has been quantitatively studied and an equation was used that expresses the behaviour of the alkaloids on both AG 1-X4 (AcO-) and microcrystalling cellulose layers.	Alkaloids	159-168	NBPF member 10	Homo sapiens	177-181
970873-2	1976	Alkaloids of leaves of Pagiantha cerifera Mrgf (Apocynacae)].	Alkaloids	0-9	MAS related GPR family member F	Homo sapiens	42-46
959312-4	1976	Results showed that both alkaloids use COMT enzymes for methylation and can also act as competitive inhibitors of COMT and MAO activity.	Alkaloids	25-34	catechol-O-methyltransferase	Rattus norvegicus	39-43
959312-4	1976	Results showed that both alkaloids use COMT enzymes for methylation and can also act as competitive inhibitors of COMT and MAO activity.	Alkaloids	25-34	catechol-O-methyltransferase	Rattus norvegicus	114-118
959312-4	1976	Results showed that both alkaloids use COMT enzymes for methylation and can also act as competitive inhibitors of COMT and MAO activity.	Alkaloids	25-34	monoamine oxidase A	Rattus norvegicus	123-126
4850478-0	1974	Alkaloids of Tylophora species from Sri Lanka.	Alkaloids	0-9	sorcin	Homo sapiens	36-39
14452969-0	1961	[Diamineoxidase and its role in the biosynthesis of alkaloids].	Alkaloids	52-61	amine oxidase copper containing 1	Homo sapiens	1-15
14184585-2	1964	EFFECTS OF THE ALKALOIDS OF THE ROOTS ON SERUM CHOLINESTERASE ACTIVITY IN HYPERTENSIVE AND NORMAL DOGS].	Alkaloids	15-24	butyrylcholinesterase	Canis lupus familiaris	47-61
18886386-0	1948	Alkaloids in Queensland Cryptocarya spp.	Alkaloids	0-9	histocompatibility minor 13	Homo sapiens	36-39
13764937-0	1960	Pharmacology of the alkaloids of Excavatia coccinea (Tejsmann and Binnendijk) Mgf.	Alkaloids	20-29	signal transducer and activator of transcription 5A	Homo sapiens	78-81
15408938-3	1950	The mixture of alkaloids (CCK 179) was found to be more effective than a single alkaloid, dihydroergocornine (DHO 180).	Alkaloids	15-24	cholecystokinin	Homo sapiens	26-29
15408938-3	1950	The mixture of alkaloids (CCK 179) was found to be more effective than a single alkaloid, dihydroergocornine (DHO 180).	Alkaloids	15-23	cholecystokinin	Homo sapiens	26-29
34048830-0	2021	New alkaloids from the noni juice with potential alpha-glucosidase inhibitory activity.	Alkaloids	4-13	sucrase-isomaltase	Homo sapiens	49-66
33781874-7	2021	We also systematically summarize the regulatory effects of natural phytochemicals on ferroptosis, and clearly indicate that saponins, terpenoids and alkaloids induce ROS- and ferritinophagy-dependent ferroptosis, whereas flavonoids and polyphenols modulate iron metabolism and nuclear factor erythroid 2-related factor 2 (NRF2) signaling to inhibit ferroptosis.	Alkaloids	149-158	NFE2 like bZIP transcription factor 2	Homo sapiens	277-320
33781874-7	2021	We also systematically summarize the regulatory effects of natural phytochemicals on ferroptosis, and clearly indicate that saponins, terpenoids and alkaloids induce ROS- and ferritinophagy-dependent ferroptosis, whereas flavonoids and polyphenols modulate iron metabolism and nuclear factor erythroid 2-related factor 2 (NRF2) signaling to inhibit ferroptosis.	Alkaloids	149-158	NFE2 like bZIP transcription factor 2	Homo sapiens	322-326
33652057-11	2021	Specifically, numerous NPs including flavonoids, gingerols, tannins, anthocyanins, triterpenes and alkaloids have been shown anti-inflammatory, antioxidant, anti-amyloidogenic, and anti-choLinesterase properties.	Alkaloids	99-108	butyrylcholinesterase	Homo sapiens	186-200
34033838-4	2021	In order to gain insights into how these alkaloids could inhibit AChE, berberine, palmatine, and cyclanoline were selected to investigate in terms of binding orientation and their key interactions with AChE using molecular docking and molecular dynamics simulations and quantum chemical calculations.	Alkaloids	41-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-69
34033838-4	2021	In order to gain insights into how these alkaloids could inhibit AChE, berberine, palmatine, and cyclanoline were selected to investigate in terms of binding orientation and their key interactions with AChE using molecular docking and molecular dynamics simulations and quantum chemical calculations.	Alkaloids	41-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	202-206
33544933-0	2021	Lamellarin 14, a Derivative of Marine Alkaloids, Inhibits the T790M/C797S Mutant Epidermal Growth Factor Receptor.	Alkaloids	38-47	epidermal growth factor receptor	Homo sapiens	81-113
33561648-3	2021	alkaloids (DNLA) protects against CCl4-induced acute liver injury.	Alkaloids	0-9	chemokine (C-C motif) ligand 4	Mus musculus	34-38
33897801-8	2021	Next, molecular docking was performed to learn about the affinity of the filtered alkaloids with the POP.	Alkaloids	82-91	prolyl endopeptidase	Homo sapiens	101-104
33833336-5	2021	These alkaloids mildly induced DSBs, and this effect was dependent on the function of topoisomerase I (Topo I) and MUS81-EME1 structure-specific endonuclease.	Alkaloids	6-15	MUS81 structure-specific endonuclease subunit	Homo sapiens	115-120
33833336-5	2021	These alkaloids mildly induced DSBs, and this effect was dependent on the function of topoisomerase I (Topo I) and MUS81-EME1 structure-specific endonuclease.	Alkaloids	6-15	essential meiotic structure-specific endonuclease 1	Homo sapiens	121-125
33359860-10	2021	CONCLUSION: These results exhibited anti-breast-cancer potential of MeZb through Nrf2-Keap1 pathway which may be due to the flavonoids, alkaloids and glycosides present in it.	Alkaloids	136-145	Kelch-like ECH-associated protein 1	Rattus norvegicus	86-91
33823775-8	2021	Apart from them, natural bioactive ingredients from plants, such as flavonoids, polyphenols, alkaloids, terpenoids, polysaccharides, and quinones are efficient in helping weight loss and improving insulin sensitivity and glycemic control.	Alkaloids	93-102	insulin	Homo sapiens	197-204
33100380-5	2021	Various phytochemicals, including polyphenols and alkaloids, have been proposed as potent inhibitors of Mpro.	Alkaloids	50-59	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	104-108
30990078-0	2021	Profiling of acetylcholinesterase inhibitory alkaloids from some Crinum, Habranthus and Zephyranthes species by GC-MS combined with multivariate analyses and in silico studies.	Alkaloids	45-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	13-33
30990078-6	2021	Furthermore, the molecular docking was performed to illustrate binding orientations of the top scoring alkaloids in the active site of human acetylcholinesterase.	Alkaloids	103-112	acetylcholinesterase (Cartwright blood group)	Homo sapiens	141-161
33652925-5	2021	Both isolated alkaloids were screened for their human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE) inhibition activity.	Alkaloids	14-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	76-81
33574755-0	2020	Corydalis Saxicola Bunting Total Alkaloids Attenuate Walker 256-Induced Bone Pain and Osteoclastogenesis by Suppressing RANKL-Induced NF-kappaB and c-Fos/NFATc1 Pathways in Rats.	Alkaloids	33-42	TNF superfamily member 11	Rattus norvegicus	120-125
33439402-5	2021	The binding free energy calculation and ligand-protein binding pattern suggested that both alkaloids could interact with AChE very well.	Alkaloids	91-100	acetylcholinesterase (Cartwright blood group)	Homo sapiens	121-125
33049346-9	2021	The mechanism of action of the alkaloids was investigated by analyzing their effects on the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway using western blotting.	Alkaloids	31-40	AKT serine/threonine kinase 1	Homo sapiens	118-121
33049346-9	2021	The mechanism of action of the alkaloids was investigated by analyzing their effects on the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway using western blotting.	Alkaloids	31-40	mechanistic target of rapamycin kinase	Homo sapiens	122-151
33049346-9	2021	The mechanism of action of the alkaloids was investigated by analyzing their effects on the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway using western blotting.	Alkaloids	31-40	AKT serine/threonine kinase 1	Homo sapiens	158-161
33049346-9	2021	The mechanism of action of the alkaloids was investigated by analyzing their effects on the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway using western blotting.	Alkaloids	31-40	mechanistic target of rapamycin kinase	Homo sapiens	162-166
33574755-0	2020	Corydalis Saxicola Bunting Total Alkaloids Attenuate Walker 256-Induced Bone Pain and Osteoclastogenesis by Suppressing RANKL-Induced NF-kappaB and c-Fos/NFATc1 Pathways in Rats.	Alkaloids	33-42	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	148-153
33574755-0	2020	Corydalis Saxicola Bunting Total Alkaloids Attenuate Walker 256-Induced Bone Pain and Osteoclastogenesis by Suppressing RANKL-Induced NF-kappaB and c-Fos/NFATc1 Pathways in Rats.	Alkaloids	33-42	nuclear factor of activated T-cells 1	Rattus norvegicus	154-160
33451160-4	2021	In the present study, we assessed several representatives of phytochemical categories consisting of alkaloids, chalcones and isothiocyanates for their inhibitory activity to nuclear localization of beta-catenin-an important event for Wnt/beta-catenin pathway activation, in lung cancer cell lines.	Alkaloids	100-109	catenin beta 1	Homo sapiens	198-210
33451160-4	2021	In the present study, we assessed several representatives of phytochemical categories consisting of alkaloids, chalcones and isothiocyanates for their inhibitory activity to nuclear localization of beta-catenin-an important event for Wnt/beta-catenin pathway activation, in lung cancer cell lines.	Alkaloids	100-109	catenin beta 1	Homo sapiens	238-250
33327436-6	2020	The cholinesterase inhibitory activity of STR extracts and its alkaloids was determined using the Ellman assay.	Alkaloids	63-72	butyrylcholinesterase	Homo sapiens	4-18
33447082-7	2021	The obtained results were associated with microfilaments and vimentin reorganization induced by the manipulation of FHOD1 together with alkaloids treatment.	Alkaloids	136-145	vimentin	Homo sapiens	61-69
33401696-0	2021	Alkaloids Analysis of Habranthus cardenasianus (Amaryllidaceae), Anti-Cholinesterase Activity and Biomass Production by Propagation Strategies.	Alkaloids	0-9	butyrylcholinesterase	Homo sapiens	70-84
33459225-8	2021	Regarding terpenoids and alkaloids, nimbin, withaferin A, andrographolide, zingiberene and, berberine, piperine and thebaine, respectively, showed binding affinity with molecular ACE-2 target in silico.	Alkaloids	25-34	angiotensin converting enzyme 2	Homo sapiens	179-184
32955004-11	2021	Interestingly, the therapeutic impact of alkaloids against blood glucose pathogenesis is mediated through a variety of signaling cascades and pathways, via inhibiting or stimulating a diversity of systems such as inhibition of alpha-glucosidase enzyme, blockade of PTP-1B, deactivation of DPP-IV, increasing insulin sensitivity and modulating the oxidative stress.	Alkaloids	41-50	sucrase-isomaltase	Homo sapiens	227-244
32955004-11	2021	Interestingly, the therapeutic impact of alkaloids against blood glucose pathogenesis is mediated through a variety of signaling cascades and pathways, via inhibiting or stimulating a diversity of systems such as inhibition of alpha-glucosidase enzyme, blockade of PTP-1B, deactivation of DPP-IV, increasing insulin sensitivity and modulating the oxidative stress.	Alkaloids	41-50	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	265-271
32955004-11	2021	Interestingly, the therapeutic impact of alkaloids against blood glucose pathogenesis is mediated through a variety of signaling cascades and pathways, via inhibiting or stimulating a diversity of systems such as inhibition of alpha-glucosidase enzyme, blockade of PTP-1B, deactivation of DPP-IV, increasing insulin sensitivity and modulating the oxidative stress.	Alkaloids	41-50	dipeptidyl peptidase 4	Homo sapiens	289-295
33194521-2	2020	Thioflavin-T assay for assessing amyloid-beta (Abeta) aggregation of these alkaloids exhibited inhibitions at 60.321% +- 2.61 (50 muM) for isomitraphylline and 43.17% +- 3.48 (50 muM) for mitraphylline.	Alkaloids	75-84	amyloid beta precursor protein	Homo sapiens	33-45
33194521-2	2020	Thioflavin-T assay for assessing amyloid-beta (Abeta) aggregation of these alkaloids exhibited inhibitions at 60.321% +- 2.61 (50 muM) for isomitraphylline and 43.17% +- 3.48 (50 muM) for mitraphylline.	Alkaloids	75-84	amyloid beta precursor protein	Homo sapiens	47-52
33130347-3	2020	Both alkaloids were able to chemosensitize the Pdr5p-overexpressing strain by synergistic interaction with fluconazole.	Alkaloids	5-14	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	47-52
33132139-3	2020	BmSUC1 was presumed to be acquired by horizontal gene transfer from bacteria based on phylogenetic analysis and related to tolerance to sugar-mimic alkaloids contained in mulberry latex.	Alkaloids	148-157	beta-fructofuranosidase	Bombyx mori	0-6
33080495-0	2020	Discovery of natural alkaloids as potent and selective inhibitors against human carboxylesterase 2.	Alkaloids	21-30	carboxylesterase 2	Homo sapiens	80-98
33132139-4	2020	Here we investigated the substrate specificity of recombinant BmSUC1 that can hydrolyze not only sucrose but also fructooligosaccharides and fructans, and revealed that the enzyme was competitively inhibited by 1,4-dideoxy-1,4-imino-D-arabinitol, one of the alkaloids.	Alkaloids	258-267	beta-fructofuranosidase	Bombyx mori	62-68
33260768-0	2020	Tropinone-Derived Alkaloids as Potent Anticancer Agents: Synthesis, Tyrosinase Inhibition, Mechanism of Action, DFT Calculation, and Molecular Docking Studies.	Alkaloids	18-27	tyrosinase	Homo sapiens	68-78
33255253-4	2020	In this study, in silico studies showed an affinity of the alkaloids for binding to the receptor-binding domain of the SARS-CoV-2 spike protein, putatively preventing it from binding to the host cell.	Alkaloids	59-68	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	130-135
33363626-5	2020	Among newer therapeutic approaches, the application of phytonutrients such as alkaloids to suppress P-gp activity in drug-resistant cancers has found an exciting niche in the arena of alternative cancer therapies.	Alkaloids	78-87	ATP binding cassette subfamily B member 1	Homo sapiens	100-104
33089728-0	2022	Prevention of SARS-CoV-2 cell entry: insight from in silico interaction of drug-like alkaloids with spike glycoprotein, human ACE2, and TMPRSS2.	Alkaloids	85-94	angiotensin converting enzyme 2	Homo sapiens	126-130
32920358-3	2020	While geissospermine inhibited only butyrylcholinesterase (BChE), the other alkaloids behaved as non-selective inhibitors of acetylcholinesterase (AChE) and BChE.	Alkaloids	76-85	butyrylcholinesterase	Homo sapiens	157-161
32920358-10	2020	In addition, the ability to inhibit hAChE and hBChE, with approximate inhibitory potencies, accredits this alkaloid for therapeutic use in the moderate to severe phase of AD.	Alkaloids	107-115	butyrylcholinesterase	Homo sapiens	46-51
32048433-3	2020	In the present study, a series of aporphinoid alkaloids were tested as potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors in vitro .	Alkaloids	34-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	81-101
32048433-3	2020	In the present study, a series of aporphinoid alkaloids were tested as potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors in vitro .	Alkaloids	34-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-107
32048433-3	2020	In the present study, a series of aporphinoid alkaloids were tested as potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors in vitro .	Alkaloids	34-55	butyrylcholinesterase	Homo sapiens	113-134
32048433-3	2020	In the present study, a series of aporphinoid alkaloids were tested as potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors in vitro .	Alkaloids	34-55	butyrylcholinesterase	Homo sapiens	136-140
33089728-0	2022	Prevention of SARS-CoV-2 cell entry: insight from in silico interaction of drug-like alkaloids with spike glycoprotein, human ACE2, and TMPRSS2.	Alkaloids	85-94	transmembrane serine protease 2	Homo sapiens	136-143
33089728-5	2022	These alkaloids were docked for their interactions with SARS-CoV-2 spike glycoprotein, ACE2, and TMPRSS2.	Alkaloids	6-15	angiotensin converting enzyme 2	Homo sapiens	87-91
33089728-5	2022	These alkaloids were docked for their interactions with SARS-CoV-2 spike glycoprotein, ACE2, and TMPRSS2.	Alkaloids	6-15	transmembrane serine protease 2	Homo sapiens	97-104
32816867-7	2020	P-gp modulatory effects have been previously demonstrated using selected TCM, including the flavonoids, alkaloids, terpenoids, coumarins, and quinonoids compounds, and some Chinese medicine extracts.	Alkaloids	104-113	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
33020380-3	2020	The aim of this paper was to fractionate and isolate alkaloids by developing an innovative vacuum liquid chromatography method for a species of Narcissus c.v. "Hawera" rarely investigated so far and establishing the inhibitory activity of acetylcholinesterase (AChE).	Alkaloids	53-62	acetylcholinesterase (Cartwright blood group)	Homo sapiens	239-259
33020380-3	2020	The aim of this paper was to fractionate and isolate alkaloids by developing an innovative vacuum liquid chromatography method for a species of Narcissus c.v. "Hawera" rarely investigated so far and establishing the inhibitory activity of acetylcholinesterase (AChE).	Alkaloids	53-62	acetylcholinesterase (Cartwright blood group)	Homo sapiens	261-265
33020380-8	2020	The combination of these techniques confirmed the presence of the alkaloids and enabled the development of a modern method for the fractionation and isolation of the compounds with strong anti-AChE activity.	Alkaloids	66-75	acetylcholinesterase (Cartwright blood group)	Homo sapiens	193-197
32557757-3	2020	Moreover, indole-containing alkaloids could exert their antibacterial activity through the inhibition of efflux pumps, the biofilm, filamentous temperature-sensitive protein Z, and methicillin-resistant Staphylococcus aureus pyruvate kinase; so, indole-containing alkaloids constitute an important source of novel antibacterial agents.	Alkaloids	28-37	AT695_RS09030	Staphylococcus aureus	225-240
32991579-4	2020	Interaction of the above-mentioned alkaloids with acetylcholinesterase enzyme and interleukins IL-6 and IL-8 was investigated in silico by molecular docking.	Alkaloids	35-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	50-70
32991579-4	2020	Interaction of the above-mentioned alkaloids with acetylcholinesterase enzyme and interleukins IL-6 and IL-8 was investigated in silico by molecular docking.	Alkaloids	35-44	interleukin 6	Homo sapiens	95-99
32991579-4	2020	Interaction of the above-mentioned alkaloids with acetylcholinesterase enzyme and interleukins IL-6 and IL-8 was investigated in silico by molecular docking.	Alkaloids	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
32325182-10	2020	Further experimental validation indicated that SC extract and alkaloids could regulate the expression of MAPK14, CASP3, CXCL8, IL-1beta, IL6, PTGS2, TNF-alpha, ESR1, and MMP9 for treatment of OP.	Alkaloids	62-71	mitogen-activated protein kinase 14a	Danio rerio	105-111
32942970-8	2021	According to the structural features, the natural COX-2 inhibitors were mainly divided into the following categories: natural phenols, flavonoids, stilbenes, terpenoids, quinones and alkaloids.	Alkaloids	183-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
32535387-1	2020	alkaloids-mediated protection against CCl4-induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway.	Alkaloids	0-9	chemokine (C-C motif) ligand 4	Mus musculus	38-42
32535387-1	2020	alkaloids-mediated protection against CCl4-induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway.	Alkaloids	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	122-126
32535387-4	2020	alkaloids (DNLA), the active ingredients of Dendrobium, protects mice from CCl4-induced liver injury, dependent on the Nrf2 signaling pathway.	Alkaloids	0-9	chemokine (C-C motif) ligand 4	Mus musculus	75-79
32535387-4	2020	alkaloids (DNLA), the active ingredients of Dendrobium, protects mice from CCl4-induced liver injury, dependent on the Nrf2 signaling pathway.	Alkaloids	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
32561335-0	2020	Effect of CYP3A inducer/inhibitor on pharmacokinetics of five alkaloids in Evodiae Fructus.	Alkaloids	62-71	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	10-15
32561335-5	2020	The results demonstrated that the metabolism of the five alkaloids of EF were inhibited in presence of CYP3A inhibitor whereas the metabolism of the five alkaloids of EF were promoted in presence of CYP3A inducer.	Alkaloids	57-66	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	103-108
32450529-6	2020	In the systemic context, only Mwar reduced eosinophilia, however, both alkaloids reduced the serum levels of OVA-specific IgE.	Alkaloids	71-80	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	109-112
32450529-11	2020	Indeed, both alkaloids reduced the NF-kB (p65) activation on granulocytes and lymphocytes, indicating that the alkaloids shut down the intracellular transduction signals underlie the transcription of TH2 cytokine gens.	Alkaloids	13-22	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	35-46
32450529-11	2020	Indeed, both alkaloids reduced the NF-kB (p65) activation on granulocytes and lymphocytes, indicating that the alkaloids shut down the intracellular transduction signals underlie the transcription of TH2 cytokine gens.	Alkaloids	13-22	heart and neural crest derivatives expressed 2	Mus musculus	200-203
32661875-2	2020	Trigonelline is one of the major alkaloids in raw coffee which has been recently introduced as potent inhibitor of Nrf2.	Alkaloids	33-42	NFE2 like bZIP transcription factor 2	Homo sapiens	115-119
32325182-10	2020	Further experimental validation indicated that SC extract and alkaloids could regulate the expression of MAPK14, CASP3, CXCL8, IL-1beta, IL6, PTGS2, TNF-alpha, ESR1, and MMP9 for treatment of OP.	Alkaloids	62-71	caspase 3, apoptosis-related cysteine peptidase a	Danio rerio	113-118
32325182-10	2020	Further experimental validation indicated that SC extract and alkaloids could regulate the expression of MAPK14, CASP3, CXCL8, IL-1beta, IL6, PTGS2, TNF-alpha, ESR1, and MMP9 for treatment of OP.	Alkaloids	62-71	chemokine (C-X-C motif) ligand 8a	Danio rerio	120-125
32325182-10	2020	Further experimental validation indicated that SC extract and alkaloids could regulate the expression of MAPK14, CASP3, CXCL8, IL-1beta, IL6, PTGS2, TNF-alpha, ESR1, and MMP9 for treatment of OP.	Alkaloids	62-71	interleukin 6 (interferon, beta 2)	Danio rerio	137-140
32325182-10	2020	Further experimental validation indicated that SC extract and alkaloids could regulate the expression of MAPK14, CASP3, CXCL8, IL-1beta, IL6, PTGS2, TNF-alpha, ESR1, and MMP9 for treatment of OP.	Alkaloids	62-71	prostaglandin-endoperoxide synthase 2a	Danio rerio	142-147
32325182-10	2020	Further experimental validation indicated that SC extract and alkaloids could regulate the expression of MAPK14, CASP3, CXCL8, IL-1beta, IL6, PTGS2, TNF-alpha, ESR1, and MMP9 for treatment of OP.	Alkaloids	62-71	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	149-158
32325182-10	2020	Further experimental validation indicated that SC extract and alkaloids could regulate the expression of MAPK14, CASP3, CXCL8, IL-1beta, IL6, PTGS2, TNF-alpha, ESR1, and MMP9 for treatment of OP.	Alkaloids	62-71	estrogen receptor 1	Danio rerio	160-164
32325182-10	2020	Further experimental validation indicated that SC extract and alkaloids could regulate the expression of MAPK14, CASP3, CXCL8, IL-1beta, IL6, PTGS2, TNF-alpha, ESR1, and MMP9 for treatment of OP.	Alkaloids	62-71	matrix metallopeptidase 9	Danio rerio	170-174
32614784-1	2021	Tissue factor (TF) which plays a key role in hemostasis and thrombosis appears to be an attractive target and medicinal plants having alkaloids inhibition TF activity benefit to cardiovascular disease (CVD).	Alkaloids	134-143	coagulation factor III, tissue factor	Homo sapiens	0-13
32655683-0	2020	Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug-drug interactions.	Alkaloids	21-30	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	93-108
32655683-0	2020	Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug-drug interactions.	Alkaloids	21-30	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	113-140
32583791-6	2020	As main findings, phenolic compounds, saponins and alkaloids interfere with cancer progression by stimulating p53 expression, which can cause pro-apoptotic onset and restrict the anti-apoptotic activity, in addition to preventing telomerase enzyme activity.	Alkaloids	51-60	tumor protein p53	Homo sapiens	110-113
32555282-6	2020	Thus, treatment with the isolated alkaloids resulted in mitochondrial membrane permeabilization consequently leading to the release of cytotoxic mitochondrial proteins to cellular cytoplasm, ROS upregulation, consequent activation of caspase-9 and -3, followed by PARP cleavage, DNA fragmentation, and apoptosis.	Alkaloids	34-43	caspase 9	Homo sapiens	234-250
32555282-6	2020	Thus, treatment with the isolated alkaloids resulted in mitochondrial membrane permeabilization consequently leading to the release of cytotoxic mitochondrial proteins to cellular cytoplasm, ROS upregulation, consequent activation of caspase-9 and -3, followed by PARP cleavage, DNA fragmentation, and apoptosis.	Alkaloids	34-43	poly(ADP-ribose) polymerase 1	Homo sapiens	264-268
32191315-6	2020	Constitutive and leaf-specific overexpression of NtERF189 increased the accumulation of foliar alkaloids in transgenic tobacco plants but negatively affected plant growth.	Alkaloids	95-104	ethylene-responsive transcription factor 13-like	Nicotiana tabacum	49-57
32583791-4	2020	Some bioactive compounds, in particular phenolic compounds, saponins and alkaloids have revealed good abilities to affect p53 expression and indirectly control the telomere length.	Alkaloids	73-82	tumor protein p53	Homo sapiens	122-125
32185162-6	2020	This is the first head-to-head comparison of this pair of nanocontainers, CB[7] and beta-CD, on their potential roles in influencing the toxicity of guest molecules and the results suggested that CB[7] could become a more promising functional excipient for reducing the inherent toxicities of active pharmaceutical ingredients, particularly alkaloids that may form relatively strong host-guest binding species with the host.	Alkaloids	341-350	ACD shelterin complex subunit and telomerase recruitment factor	Danio rerio	84-91
32422877-2	2020	In the present study, the binding affinity of naturally occurring alkaloids, hordenine, vincamine, tryptamine, cinchonine, and colcemid was measured with PDK3.	Alkaloids	66-75	pyruvate dehydrogenase kinase 3	Homo sapiens	154-158
32155491-4	2020	Alkaloid isolation from root extract of Zanthoxylum rigidum was carried out using multi-step chromatography and TLC-bioautography against acetylcholinesterase (AChE) giving eight purified isoquinoline alkaloids.	Alkaloids	0-8	acetylcholinesterase (Cartwright blood group)	Homo sapiens	160-164
32155491-9	2020	In addition, these alkaloids presented moderate Abeta1-42 anti-aggregation activity and MAO-A inhibition with IC50 values between 0.5 and 2 microM.	Alkaloids	19-28	monoamine oxidase A	Homo sapiens	88-93
32105756-8	2020	There are not enough clinical data available for these phytochemicals to follow their fingerprint in human, but current studies generally recommending PAs as potent alpha-glucosidase inhibitors.	Alkaloids	151-154	sucrase-isomaltase	Homo sapiens	165-182
32365707-1	2020	The mu opioid receptor (MOR) is the primary target for analgesia of endogenous opioid peptides, alkaloids, synthetic small molecules with diverse scaffolds, and peptidomimetics.	Alkaloids	96-105	opioid receptor mu 1	Homo sapiens	4-22
32365707-1	2020	The mu opioid receptor (MOR) is the primary target for analgesia of endogenous opioid peptides, alkaloids, synthetic small molecules with diverse scaffolds, and peptidomimetics.	Alkaloids	96-105	opioid receptor mu 1	Homo sapiens	24-27
32134650-5	2020	Alkaloids 1-4 were evaluated for their potential to inhibit AGE formation and showed inhibition of 62.9%, 83.3%, 26.1%, and 98.2% (150 muM), respectively.	Alkaloids	0-9	latexin	Homo sapiens	135-138
32744961-7	2020	Activation of PPAR-alpha, SIRT3/1, and FXR through many cascades by plant compounds such as terpenoids, iridoids, flavonoids, alkaloids, phenols, tannins, carbohydrates, and phyto cannabinoids recover the diabetic complications.	Alkaloids	126-135	peroxisome proliferator activated receptor alpha	Homo sapiens	14-24
31865520-10	2020	Furthermore, DNLA administration also reduced the levels of the pyroptosis-associated proteins Caspase-1 and gasdermin-D, particularly in the hippocampal CA1 region.	Alkaloids	13-17	caspase 1	Mus musculus	95-104
31865520-10	2020	Furthermore, DNLA administration also reduced the levels of the pyroptosis-associated proteins Caspase-1 and gasdermin-D, particularly in the hippocampal CA1 region.	Alkaloids	13-17	gasdermin D	Mus musculus	109-120
31865520-10	2020	Furthermore, DNLA administration also reduced the levels of the pyroptosis-associated proteins Caspase-1 and gasdermin-D, particularly in the hippocampal CA1 region.	Alkaloids	13-17	carbonic anhydrase 1	Mus musculus	154-157
31865520-12	2020	OGD/R-associated ultrastructural damage was seen to improve following DNLA administration, likely due to the regulation of the tight junction protein Pannexin-1 by DNLA.	Alkaloids	70-74	pannexin 1	Mus musculus	150-160
31865520-12	2020	OGD/R-associated ultrastructural damage was seen to improve following DNLA administration, likely due to the regulation of the tight junction protein Pannexin-1 by DNLA.	Alkaloids	164-168	pannexin 1	Mus musculus	150-160
32744961-7	2020	Activation of PPAR-alpha, SIRT3/1, and FXR through many cascades by plant compounds such as terpenoids, iridoids, flavonoids, alkaloids, phenols, tannins, carbohydrates, and phyto cannabinoids recover the diabetic complications.	Alkaloids	126-135	sirtuin 3	Homo sapiens	26-33
32744961-7	2020	Activation of PPAR-alpha, SIRT3/1, and FXR through many cascades by plant compounds such as terpenoids, iridoids, flavonoids, alkaloids, phenols, tannins, carbohydrates, and phyto cannabinoids recover the diabetic complications.	Alkaloids	126-135	nuclear receptor subfamily 1 group H member 4	Homo sapiens	39-42
31816576-0	2020	Isosteroid alkaloids with different chemical structures from Fritillariae cirrhosae bulbus alleviate LPS-induced inflammatory response in RAW 264.7 cells by MAPK signaling pathway.	Alkaloids	0-20	toll-like receptor 4	Mus musculus	101-104
31816576-0	2020	Isosteroid alkaloids with different chemical structures from Fritillariae cirrhosae bulbus alleviate LPS-induced inflammatory response in RAW 264.7 cells by MAPK signaling pathway.	Alkaloids	0-20	mitogen-activated protein kinase 1	Mus musculus	157-161
31816576-3	2020	In this study, the anti-inflammatory activitives and the potential mechanisms of five isosteroid alkaloids from F. Cirrhosae Bulbus were investigated in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells.	Alkaloids	86-106	toll-like receptor 4	Mus musculus	173-176
31816576-6	2020	Treatment with the five isosteroid alkaloids in appropriate concentrations could reduce the production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in supernatant, and suppressed the mRNA expressions of TNF-alpha and IL-6.	Alkaloids	24-44	tumor necrosis factor	Mus musculus	125-152
31816576-6	2020	Treatment with the five isosteroid alkaloids in appropriate concentrations could reduce the production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in supernatant, and suppressed the mRNA expressions of TNF-alpha and IL-6.	Alkaloids	24-44	tumor necrosis factor	Mus musculus	154-163
31816576-6	2020	Treatment with the five isosteroid alkaloids in appropriate concentrations could reduce the production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in supernatant, and suppressed the mRNA expressions of TNF-alpha and IL-6.	Alkaloids	24-44	interleukin 6	Mus musculus	169-182
31816576-6	2020	Treatment with the five isosteroid alkaloids in appropriate concentrations could reduce the production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in supernatant, and suppressed the mRNA expressions of TNF-alpha and IL-6.	Alkaloids	24-44	interleukin 6	Mus musculus	184-188
31816576-6	2020	Treatment with the five isosteroid alkaloids in appropriate concentrations could reduce the production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in supernatant, and suppressed the mRNA expressions of TNF-alpha and IL-6.	Alkaloids	24-44	tumor necrosis factor	Mus musculus	245-254
31816576-6	2020	Treatment with the five isosteroid alkaloids in appropriate concentrations could reduce the production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in supernatant, and suppressed the mRNA expressions of TNF-alpha and IL-6.	Alkaloids	24-44	interleukin 6	Mus musculus	259-263
31816576-7	2020	Meanwhile, the five isosteroid alkaloids significantly inhibited the phosphorylated activation of mitogen activated protein kinase (MAPK) signaling pathways, including extracellular signal-regulated kinase (ERK1/2), p38 MAPK and c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).	Alkaloids	20-40	mitogen-activated protein kinase 1	Mus musculus	132-136
31816576-7	2020	Meanwhile, the five isosteroid alkaloids significantly inhibited the phosphorylated activation of mitogen activated protein kinase (MAPK) signaling pathways, including extracellular signal-regulated kinase (ERK1/2), p38 MAPK and c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).	Alkaloids	20-40	mitogen-activated protein kinase 3	Mus musculus	207-213
31816576-7	2020	Meanwhile, the five isosteroid alkaloids significantly inhibited the phosphorylated activation of mitogen activated protein kinase (MAPK) signaling pathways, including extracellular signal-regulated kinase (ERK1/2), p38 MAPK and c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).	Alkaloids	20-40	mitogen-activated protein kinase 14	Mus musculus	216-224
31816576-7	2020	Meanwhile, the five isosteroid alkaloids significantly inhibited the phosphorylated activation of mitogen activated protein kinase (MAPK) signaling pathways, including extracellular signal-regulated kinase (ERK1/2), p38 MAPK and c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).	Alkaloids	20-40	mitogen-activated protein kinase 8	Mus musculus	286-294
31816576-8	2020	These results demonstrated that isosteroid alkaloids from F. Cirrhosae Bulbus exert anti-inflammatory effects by down-regulating the level of inflammatory mediators via mediation of MAPK phosphorylation in LPS-induced RAW264.7 macrophages, thus could be candidates for the prevention and treatment of inflammatory diseases.	Alkaloids	32-52	mitogen-activated protein kinase 1	Mus musculus	182-186
31816576-8	2020	These results demonstrated that isosteroid alkaloids from F. Cirrhosae Bulbus exert anti-inflammatory effects by down-regulating the level of inflammatory mediators via mediation of MAPK phosphorylation in LPS-induced RAW264.7 macrophages, thus could be candidates for the prevention and treatment of inflammatory diseases.	Alkaloids	32-52	toll-like receptor 4	Mus musculus	206-209
31751584-6	2020	Additionally, immunohistochemistry assays showed that neuronal death and glial activation were prevented by the alkaloids in the hippocampus CA1, CA3 and dentate gyrus regions at both hemispheres indistinctly 15 days after status epilepticus induction.	Alkaloids	112-121	carbonic anhydrase 1	Rattus norvegicus	141-144
31751584-6	2020	Additionally, immunohistochemistry assays showed that neuronal death and glial activation were prevented by the alkaloids in the hippocampus CA1, CA3 and dentate gyrus regions at both hemispheres indistinctly 15 days after status epilepticus induction.	Alkaloids	112-121	carbonic anhydrase 3	Rattus norvegicus	146-149
32003702-5	2020	RESULTS: More than one hundred anticancer alkaloids were disclosed in Chinese patents and their mode of action referred to arresting cell cycle, inhibiting protein kinases, affecting DNA synthesis and p53 expression, etc.	Alkaloids	42-51	tumor protein p53	Homo sapiens	201-204
31647221-0	2019	A Biomimetic, One-Step Transformation of Simple Indolic Compounds to Malassezia-Related Alkaloids with High AhR Potency and Efficacy.	Alkaloids	88-97	aryl hydrocarbon receptor	Homo sapiens	108-111
31624922-0	2019	MHTP, a synthetic tetratetrahydroisoquinoline alkaloid, attenuates lipopolysaccharide-induced acute lung injury via p38MAPK/p65NF-kappaB signaling pathway-TLR4 dependent.	Alkaloids	18-54	mitogen-activated protein kinase 14	Mus musculus	116-123
31624922-0	2019	MHTP, a synthetic tetratetrahydroisoquinoline alkaloid, attenuates lipopolysaccharide-induced acute lung injury via p38MAPK/p65NF-kappaB signaling pathway-TLR4 dependent.	Alkaloids	18-54	toll-like receptor 4	Mus musculus	155-159
31387012-0	2019	Purification of tertiary and quaternary alkaloids from Rhizoma Corydalis using reversed-phase/weak cation-exchange mixed-mode class separation combined with preparative C18 and silica based strong cation-exchange chromatography.	Alkaloids	40-49	Bardet-Biedl syndrome 9	Homo sapiens	169-172
31489680-10	2019	Qualitative characterisation of APM indicated existence of alkaloids, terpenoids, coumarins, cardiac glycosides, phenols, flavonoids, saponins, tannins and sterols.	Alkaloids	59-68	alanyl aminopeptidase, membrane	Rattus norvegicus	32-35
31473429-1	2019	Full-aromatic and partially hydrogenated beta-carboline (betaC) derivatives constitute a group of alkaloids widely distributed in a great variety of living systems.	Alkaloids	98-107	colony stimulating factor 2 receptor subunit beta	Homo sapiens	41-63
31453659-5	2019	The most important biological activities of Artemisia"s alkaloids are including hepatoprotective, local anesthetic, beta-galactosidase, and antiparasitic activities; treatment of angina pectoris, opening blocked arteries, as a sleep-inducing agents and inhibition of HIV viral protease, CYP450, melanin biosynthesis, human carbonic anhydrase, [3H]-AEA metabolism, kinases, and DNA polymerase beta1 .	Alkaloids	56-65	galactosidase beta 1	Homo sapiens	116-134
31326115-0	2019	Ethylene response factor NtERF91 positively regulates alkaloid accumulations in tobacco (Nicotiana tabacum L.).	Alkaloids	54-62	ethylene-responsive transcription factor 13-like	Nicotiana tabacum	25-32
31326115-5	2019	Ectopic overexpression of NtERF91 not only increased the expression of most nicotine biosynthetic genes, but also altered alkaloid accumulation profile, resulting in dramatically anatabine accumulation.	Alkaloids	122-130	ethylene-responsive transcription factor 13-like	Nicotiana tabacum	26-33
31220673-1	2019	Alkaloids have always been a great source of cholinesterase inhibitors.	Alkaloids	0-9	butyrylcholinesterase	Homo sapiens	45-59
31051218-15	2019	CONCLUSIONS: The three effective fractions of Radix Isatidis have remarkable synergistic anti-RSV effects in vitro and in vivo, and total alkaloids and lignans show multi-target synergistic effects via the RIG-I and MDA5 signaling pathways.	Alkaloids	138-147	DExD/H-box helicase 58	Homo sapiens	206-211
31220673-11	2019	The molecular modeling studies with AChE and BChE have shown that both alkaloids were tightly packed inside the active site gorge (site 1) via multiple pi-pi and cation-pi interactions.	Alkaloids	71-80	acetylcholinesterase (Cartwright blood group)	Homo sapiens	36-40
31220673-11	2019	The molecular modeling studies with AChE and BChE have shown that both alkaloids were tightly packed inside the active site gorge (site 1) via multiple pi-pi and cation-pi interactions.	Alkaloids	71-80	butyrylcholinesterase	Homo sapiens	45-49
31322315-5	2019	Although some natural compounds such as terpenoids and alkaloids were reported to protect the nervous system by Nrf2 activating, flavonoids and phenolic compounds represent the majority of the reported neuroprotective natural substances that activate Nrf2.	Alkaloids	55-64	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116
31322315-5	2019	Although some natural compounds such as terpenoids and alkaloids were reported to protect the nervous system by Nrf2 activating, flavonoids and phenolic compounds represent the majority of the reported neuroprotective natural substances that activate Nrf2.	Alkaloids	55-64	NFE2 like bZIP transcription factor 2	Homo sapiens	251-255
31430938-0	2019	Perennial Ryegrass Alkaloids Increase Respiration Rate and Decrease Plasma Prolactin in Merino Sheep under Both Thermoneutral and Mild Heat Conditions.	Alkaloids	19-28	prolactin	Ovis aries	75-84
31361502-1	2019	The heterocyclic portions of yuzurimine-type alkaloids, such as deoxyyuzurimine and macrodaphnine, were synthesized by using a stereoselective hydroboration-oxidation reaction to install the C20 methyl group, the intramolecular Mitsunobu reaction to construct the E-ring portion, and the intramolecular SN2 reaction to construct the F-ring portion as key steps.	Alkaloids	45-54	solute carrier family 38 member 5	Homo sapiens	303-306
31382492-0	2019	Multiple Modulation of Acid-Sensing Ion Channel 1a by the Alkaloid Daurisoline.	Alkaloids	58-66	acid sensing ion channel subunit 1	Homo sapiens	23-49
31152736-0	2019	Structure-based virtual screening leading to discovery of highly selective butyrylcholinesterase inhibitors with solanaceous alkaloid scaffolds.	Alkaloids	125-133	butyrylcholinesterase	Homo sapiens	75-96
31152736-3	2019	As a result, a set of new, selective inhibitors of human BChE were identified from natural products with solanaceous alkaloid scaffolds.	Alkaloids	117-125	butyrylcholinesterase	Homo sapiens	57-61
31051218-15	2019	CONCLUSIONS: The three effective fractions of Radix Isatidis have remarkable synergistic anti-RSV effects in vitro and in vivo, and total alkaloids and lignans show multi-target synergistic effects via the RIG-I and MDA5 signaling pathways.	Alkaloids	138-147	interferon induced with helicase C domain 1	Homo sapiens	216-220
31514980-1	2019	Current study systematically investigated the interaction of two alkaloids, anisodine and monocrotaline, with organic cation transporter OCT1, 2, 3, MATE1 and MATE2-K by using in vitro stably transfected HEK293 cells.	Alkaloids	65-74	solute carrier family 22 member 1	Homo sapiens	137-147
31514980-1	2019	Current study systematically investigated the interaction of two alkaloids, anisodine and monocrotaline, with organic cation transporter OCT1, 2, 3, MATE1 and MATE2-K by using in vitro stably transfected HEK293 cells.	Alkaloids	65-74	solute carrier family 47 member 1	Homo sapiens	149-154
31234546-5	2019	Notably, several diterpenoid alkaloids were more potent against MDR subline KB-VIN cells than the parental drug-sensitive KB cells.	Alkaloids	29-38	long intergenic non-protein coding RNA 1191	Homo sapiens	79-82
30784931-0	2019	Alkaloids from Nelumbinis Plumula (AFNP) ameliorate aortic remodeling via RhoA/ROCK pathway.	Alkaloids	0-9	ras homolog family member A	Rattus norvegicus	74-78
31048127-0	2019	Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation.	Alkaloids	8-16	synuclein alpha	Homo sapiens	49-64
30756408-7	2019	Secondly, network pharmacology analysis showed that the key protein PTGS2 was targeted by four alkaloids, and that the competition among them might be allevited by AR.	Alkaloids	95-104	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	68-73
30756408-8	2019	Thirdly, molecular docking exhibited interactions between the alkaloids and PTGS2 through H and pi-pi bonds, and the same residue formed interactions with different alkaloids, which account for the toxicity of these alkaloids, and these were confirmed by the cell viability assay.	Alkaloids	62-71	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	76-81
30801949-0	2019	Clinanthus microstephium, an Amaryllidaceae Species with Cholinesterase Inhibitor Alkaloids: Structure-Activity Analysis of Haemanthamine Skeleton Derivatives.	Alkaloids	82-91	butyrylcholinesterase	Homo sapiens	57-71
30907037-0	2019	Alkaloids from nux vomica suppresses colon cancer cell growth through Wnt/beta-catenin signaling pathway.	Alkaloids	0-9	catenin beta 1	Homo sapiens	74-86
31022843-7	2019	A number of teratogens such as alcohol, statins and steroidal alkaloids also disrupt key aspects of Hedgehog signal transduction, leading to developmental defects that are similar, if not identical, to those of Hedgehog pathway mutations.	Alkaloids	62-71	hedgehog	Drosophila melanogaster	100-108
31022843-7	2019	A number of teratogens such as alcohol, statins and steroidal alkaloids also disrupt key aspects of Hedgehog signal transduction, leading to developmental defects that are similar, if not identical, to those of Hedgehog pathway mutations.	Alkaloids	62-71	hedgehog	Drosophila melanogaster	211-219
30959739-6	2019	Furthermore, both alkaloids demonstrated a competitive-type pattern of hAChE inhibition and bind, most probably, in the same AChE sub-site as its substrate.	Alkaloids	18-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	71-76
30959739-6	2019	Furthermore, both alkaloids demonstrated a competitive-type pattern of hAChE inhibition and bind, most probably, in the same AChE sub-site as its substrate.	Alkaloids	18-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-76
30703480-10	2019	In some alkaloids, activation of the nuclear factor Nrf2 pathway was documented to be the grounds for inhibition of NADPH-oxidase.	Alkaloids	8-17	NFE2 like bZIP transcription factor 2	Homo sapiens	52-56
30703480-11	2019	Interestingly, many alkaloids can behave both as anti-oxidants and pro-oxidants depending on conditions and pro-oxidation might be the reason for activation of Nrf2.	Alkaloids	20-29	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164
31090328-9	2019	Western blot and flow cytometry showed that the total alkaloids of Coptidis Rhizoma combined with exercise could down-regulate the protein expression levels of ERalpha,CDK4,CDK6,cyclin D1,CDK2 and cyclin E in cancer cells,block the transformation of G1/S in 4 T1 cell cycle,and inhibit DNA synthesis in breast cancer cells.	Alkaloids	54-63	estrogen receptor 1 (alpha)	Mus musculus	160-167
31090328-9	2019	Western blot and flow cytometry showed that the total alkaloids of Coptidis Rhizoma combined with exercise could down-regulate the protein expression levels of ERalpha,CDK4,CDK6,cyclin D1,CDK2 and cyclin E in cancer cells,block the transformation of G1/S in 4 T1 cell cycle,and inhibit DNA synthesis in breast cancer cells.	Alkaloids	54-63	cyclin-dependent kinase 4	Mus musculus	168-172
31090328-9	2019	Western blot and flow cytometry showed that the total alkaloids of Coptidis Rhizoma combined with exercise could down-regulate the protein expression levels of ERalpha,CDK4,CDK6,cyclin D1,CDK2 and cyclin E in cancer cells,block the transformation of G1/S in 4 T1 cell cycle,and inhibit DNA synthesis in breast cancer cells.	Alkaloids	54-63	cyclin-dependent kinase 6	Mus musculus	173-177
31090328-9	2019	Western blot and flow cytometry showed that the total alkaloids of Coptidis Rhizoma combined with exercise could down-regulate the protein expression levels of ERalpha,CDK4,CDK6,cyclin D1,CDK2 and cyclin E in cancer cells,block the transformation of G1/S in 4 T1 cell cycle,and inhibit DNA synthesis in breast cancer cells.	Alkaloids	54-63	cyclin D1	Mus musculus	178-187
31090328-9	2019	Western blot and flow cytometry showed that the total alkaloids of Coptidis Rhizoma combined with exercise could down-regulate the protein expression levels of ERalpha,CDK4,CDK6,cyclin D1,CDK2 and cyclin E in cancer cells,block the transformation of G1/S in 4 T1 cell cycle,and inhibit DNA synthesis in breast cancer cells.	Alkaloids	54-63	cyclin-dependent kinase 2	Mus musculus	188-192
31011359-4	2019	The plasma biochemical indexes showed that therapeutic dose of lipid-soluble alkaloids of FZ could significantly inhibit the concentrations of IL-1beta, TNF-alpha, and IFN-gamma in AIA rats, and combination with total glucosides of peony could further reduce the concentration of IL-1beta.	Alkaloids	77-86	interleukin 1 beta	Rattus norvegicus	143-151
31011359-4	2019	The plasma biochemical indexes showed that therapeutic dose of lipid-soluble alkaloids of FZ could significantly inhibit the concentrations of IL-1beta, TNF-alpha, and IFN-gamma in AIA rats, and combination with total glucosides of peony could further reduce the concentration of IL-1beta.	Alkaloids	77-86	tumor necrosis factor	Rattus norvegicus	153-162
31011359-4	2019	The plasma biochemical indexes showed that therapeutic dose of lipid-soluble alkaloids of FZ could significantly inhibit the concentrations of IL-1beta, TNF-alpha, and IFN-gamma in AIA rats, and combination with total glucosides of peony could further reduce the concentration of IL-1beta.	Alkaloids	77-86	interferon gamma	Rattus norvegicus	168-177
31011359-4	2019	The plasma biochemical indexes showed that therapeutic dose of lipid-soluble alkaloids of FZ could significantly inhibit the concentrations of IL-1beta, TNF-alpha, and IFN-gamma in AIA rats, and combination with total glucosides of peony could further reduce the concentration of IL-1beta.	Alkaloids	77-86	interleukin 1 beta	Rattus norvegicus	280-288
30380451-0	2019	Synthesis and 2D-QSAR study of dispiropyrrolodinyl-oxindole based alkaloids as cholinesterase inhibitors.	Alkaloids	66-75	butyrylcholinesterase	Homo sapiens	79-93
30669459-2	2019	In this study, three kinds of Lotus plumules from different regions of China were selected to observe the preventive effects of extracted alkaloids on CCl4-induced liver injuries.	Alkaloids	138-147	chemokine (C-C motif) ligand 4	Mus musculus	151-155
30668438-11	2019	CONCLUSION: Alkaloids from N. latifolia may serve as a source of new PCSK9 inhibitors.	Alkaloids	12-21	proprotein convertase subtilisin/kexin type 9	Homo sapiens	69-74
30669459-3	2019	Animal experiments revealed that alkaloids extracted from Lotus plumules decreased the serum AST (aspartate aminotransferase), ALT (alanine aminotransferase), and TBIL (total bilirubin) levels, enhanced SOD (superoxide dismutase) activity, and reduced MDA (malondialdehyde) level in the liver tissues of mice with liver injury.	Alkaloids	33-42	glutamic pyruvic transaminase, soluble	Mus musculus	132-156
30669459-4	2019	H&E observation confirmed that alkaloids from Lotus plumules could alleviate CCl4-induced injuries of liver tissues and inhibit the inflammatory effect on hepatocytes.	Alkaloids	35-44	chemokine (C-C motif) ligand 4	Mus musculus	81-85
30669459-5	2019	Further qPCR experiments also demonstrated that alkaloids from Lotus plumules upregulated the expression of IkappaB-alpha (inhibitor of NF-kappaB alpha), Cu/Zn-SOD (copper/zinc superoxide dismutase), Mn-SOD (manganese superoxide dismutase), and CAT (catalase) mRNA and downregulated TNF-alpha (tumor necrosis factor alpha) and NF-kappaB (nuclear factor kappa B) expression in the liver tissues of mice with liver injury.	Alkaloids	48-57	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	108-121
30669459-5	2019	Further qPCR experiments also demonstrated that alkaloids from Lotus plumules upregulated the expression of IkappaB-alpha (inhibitor of NF-kappaB alpha), Cu/Zn-SOD (copper/zinc superoxide dismutase), Mn-SOD (manganese superoxide dismutase), and CAT (catalase) mRNA and downregulated TNF-alpha (tumor necrosis factor alpha) and NF-kappaB (nuclear factor kappa B) expression in the liver tissues of mice with liver injury.	Alkaloids	48-57	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	136-145
30669459-5	2019	Further qPCR experiments also demonstrated that alkaloids from Lotus plumules upregulated the expression of IkappaB-alpha (inhibitor of NF-kappaB alpha), Cu/Zn-SOD (copper/zinc superoxide dismutase), Mn-SOD (manganese superoxide dismutase), and CAT (catalase) mRNA and downregulated TNF-alpha (tumor necrosis factor alpha) and NF-kappaB (nuclear factor kappa B) expression in the liver tissues of mice with liver injury.	Alkaloids	48-57	superoxide dismutase 1, soluble	Mus musculus	154-163
30669459-5	2019	Further qPCR experiments also demonstrated that alkaloids from Lotus plumules upregulated the expression of IkappaB-alpha (inhibitor of NF-kappaB alpha), Cu/Zn-SOD (copper/zinc superoxide dismutase), Mn-SOD (manganese superoxide dismutase), and CAT (catalase) mRNA and downregulated TNF-alpha (tumor necrosis factor alpha) and NF-kappaB (nuclear factor kappa B) expression in the liver tissues of mice with liver injury.	Alkaloids	48-57	superoxide dismutase 2, mitochondrial	Mus musculus	200-206
30669459-5	2019	Further qPCR experiments also demonstrated that alkaloids from Lotus plumules upregulated the expression of IkappaB-alpha (inhibitor of NF-kappaB alpha), Cu/Zn-SOD (copper/zinc superoxide dismutase), Mn-SOD (manganese superoxide dismutase), and CAT (catalase) mRNA and downregulated TNF-alpha (tumor necrosis factor alpha) and NF-kappaB (nuclear factor kappa B) expression in the liver tissues of mice with liver injury.	Alkaloids	48-57	superoxide dismutase 2, mitochondrial	Mus musculus	208-238
30669459-5	2019	Further qPCR experiments also demonstrated that alkaloids from Lotus plumules upregulated the expression of IkappaB-alpha (inhibitor of NF-kappaB alpha), Cu/Zn-SOD (copper/zinc superoxide dismutase), Mn-SOD (manganese superoxide dismutase), and CAT (catalase) mRNA and downregulated TNF-alpha (tumor necrosis factor alpha) and NF-kappaB (nuclear factor kappa B) expression in the liver tissues of mice with liver injury.	Alkaloids	48-57	tumor necrosis factor	Mus musculus	283-292
30669459-5	2019	Further qPCR experiments also demonstrated that alkaloids from Lotus plumules upregulated the expression of IkappaB-alpha (inhibitor of NF-kappaB alpha), Cu/Zn-SOD (copper/zinc superoxide dismutase), Mn-SOD (manganese superoxide dismutase), and CAT (catalase) mRNA and downregulated TNF-alpha (tumor necrosis factor alpha) and NF-kappaB (nuclear factor kappa B) expression in the liver tissues of mice with liver injury.	Alkaloids	48-57	tumor necrosis factor	Mus musculus	294-321
30669459-5	2019	Further qPCR experiments also demonstrated that alkaloids from Lotus plumules upregulated the expression of IkappaB-alpha (inhibitor of NF-kappaB alpha), Cu/Zn-SOD (copper/zinc superoxide dismutase), Mn-SOD (manganese superoxide dismutase), and CAT (catalase) mRNA and downregulated TNF-alpha (tumor necrosis factor alpha) and NF-kappaB (nuclear factor kappa B) expression in the liver tissues of mice with liver injury.	Alkaloids	48-57	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	327-336
30669459-5	2019	Further qPCR experiments also demonstrated that alkaloids from Lotus plumules upregulated the expression of IkappaB-alpha (inhibitor of NF-kappaB alpha), Cu/Zn-SOD (copper/zinc superoxide dismutase), Mn-SOD (manganese superoxide dismutase), and CAT (catalase) mRNA and downregulated TNF-alpha (tumor necrosis factor alpha) and NF-kappaB (nuclear factor kappa B) expression in the liver tissues of mice with liver injury.	Alkaloids	48-57	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	338-360
30669459-6	2019	All three kinds of alkaloids from Lotus plumules could prevent CCl4-induced liver injuries by regulating the levels of oxidative stress and inflammation in mice, and the therapeutic effect was comparable to that of silymarin, the medicine commonly used in the treatment of liver diseases.	Alkaloids	19-28	chemokine (C-C motif) ligand 4	Mus musculus	63-67
30669459-3	2019	Animal experiments revealed that alkaloids extracted from Lotus plumules decreased the serum AST (aspartate aminotransferase), ALT (alanine aminotransferase), and TBIL (total bilirubin) levels, enhanced SOD (superoxide dismutase) activity, and reduced MDA (malondialdehyde) level in the liver tissues of mice with liver injury.	Alkaloids	33-42	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	93-96
30669459-3	2019	Animal experiments revealed that alkaloids extracted from Lotus plumules decreased the serum AST (aspartate aminotransferase), ALT (alanine aminotransferase), and TBIL (total bilirubin) levels, enhanced SOD (superoxide dismutase) activity, and reduced MDA (malondialdehyde) level in the liver tissues of mice with liver injury.	Alkaloids	33-42	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	98-124
30669459-3	2019	Animal experiments revealed that alkaloids extracted from Lotus plumules decreased the serum AST (aspartate aminotransferase), ALT (alanine aminotransferase), and TBIL (total bilirubin) levels, enhanced SOD (superoxide dismutase) activity, and reduced MDA (malondialdehyde) level in the liver tissues of mice with liver injury.	Alkaloids	33-42	glutamic pyruvic transaminase, soluble	Mus musculus	127-130
29756568-5	2019	In this review, the use of aporphines in nature for treating Alzheimer"s disease, alkaloids isolated from natural and/or synthetic sources have been used principally as cholinesterase inhibitors (acetyl- and butyrylcholinesterase) as galantamine, for instance, though its use has been questioned for being slightly effective or marginal.	Alkaloids	82-91	butyrylcholinesterase	Homo sapiens	169-183
29714135-0	2019	Natural Alkaloids Intervening the Insulin Pathway: New Hopes for Anti-Diabetic Agents?	Alkaloids	8-17	insulin	Homo sapiens	34-41
29714135-4	2019	PURPOSE: To discuss current concepts on the anti-diabetic impact of certain alkaloids, with special reference to their molecular targets throughout the insulin-signaling pathway.	Alkaloids	76-85	insulin	Homo sapiens	152-159
29714135-5	2019	METHODOLOGY: Upon in-depth search in the SCOPUS and PUBMED databases, the literature on alkaloids with insulin secretion/sensitization properties was critically reviewed.	Alkaloids	88-97	insulin	Homo sapiens	103-110
29714135-9	2019	DISCUSSION: Growing evidence suggests the ability of specific alkaloids to intervene in the insulin-signal transduction pathway, reverse molecular defects resulting in insulin resistance and glucose intolerance and improve disease complications, in-vitro and in-vivo.	Alkaloids	62-71	insulin	Homo sapiens	92-99
29714135-9	2019	DISCUSSION: Growing evidence suggests the ability of specific alkaloids to intervene in the insulin-signal transduction pathway, reverse molecular defects resulting in insulin resistance and glucose intolerance and improve disease complications, in-vitro and in-vivo.	Alkaloids	62-71	insulin	Homo sapiens	168-175
30618767-1	2018	Alkaloids Decreases the Level of Intracellular beta-Amyloid by Improving Impaired Autolysosomal Proteolysis in APP/PS1 Mice.	Alkaloids	0-9	amyloid beta (A4) precursor protein	Mus musculus	111-118
29860170-7	2018	In addition, protopine was demonstrated as a binder of c-myb G-quadruplex as screened from a library of natural alkaloids using ESI-MS method.	Alkaloids	112-121	MYB proto-oncogene, transcription factor	Homo sapiens	55-60
30398210-1	2018	The proto-alkaloid synephrine {SYN; systematic name: 4-[1-hydroxy-2-(methylamino)ethyl]phenol}, C9H13NO2, is found to crystallize as a neutral molecule in the racemate and as a zwitterion in the pure enantiomer, in which the phenolic H atom has been transferred to the amino group.	Alkaloids	10-18	synemin	Homo sapiens	31-34
30419265-7	2018	All of these alkaloids are S-configured at C-3 and bear an oxygen function at C-6, and are, thus, typical Ancistrocladaceae-type compounds.	Alkaloids	13-22	complement C3	Homo sapiens	43-46
30419265-7	2018	All of these alkaloids are S-configured at C-3 and bear an oxygen function at C-6, and are, thus, typical Ancistrocladaceae-type compounds.	Alkaloids	13-22	complement C6	Homo sapiens	78-81
30121557-1	2018	A novel controllable hydrophilic thermo-responsive molecularly imprinted resin (T-MIR) with a switchable zipper-like architecture was synthesized in the aqueous phase and applied to the selective recognition and extraction of alkaloids by positive temperature regulation.	Alkaloids	226-235	membrane associated ring-CH-type finger 8	Homo sapiens	82-85
30121557-4	2018	The highest theory adsorption ability (33.44 mg/g) and recognition ability (imprinting factor: 4.71) of T-MIR was activated between poly(AMPS) and poly(AAm) in the zipper-like architecture at 35  C. T-MIR was then applied to the selective recognition alkaloids by dispersive solid phase extraction.	Alkaloids	251-260	membrane associated ring-CH-type finger 8	Homo sapiens	106-109
30121557-7	2018	In contrast to previous thermo-responsive materials, this switchable zipper-like hydrophilic T-MIR with good adsorption, specificity recognition, and excellent temperature controllable properties provides a unique alternative to the selective recognition and controlled rebind-release alkaloids by the temperature signal.	Alkaloids	285-294	membrane associated ring-CH-type finger 8	Homo sapiens	95-98
30405413-4	2018	However, several plant species producing diverse classes of alkaloids, coumarins, terpenes, and polyphenols have been assessed for their anti-AChE activity, becoming potential candidates for new anti-AD drugs.	Alkaloids	60-69	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-146
30286809-0	2018	Therapeutic and immunoregulatory effects of water-soluble alkaloids E2-a from Sophora moorcroftiana seeds as a novel potential agent against echinococcosis in experimentally protoscolex-infected mice.	Alkaloids	58-67	transcription factor 3	Mus musculus	68-72
30237956-0	2018	Immunomodulation of IL-1, IL-6 and IL-8 cytokines by Prosopis juliflora alkaloids during bovine sub-clinical mastitis.	Alkaloids	72-81	interferon beta-2	Bos taurus	26-30
30237956-0	2018	Immunomodulation of IL-1, IL-6 and IL-8 cytokines by Prosopis juliflora alkaloids during bovine sub-clinical mastitis.	Alkaloids	72-81	C-X-C motif chemokine ligand 8	Bos taurus	35-39
30059720-3	2018	All of the alkaloids are S-configured at C-3 and possess an oxygen function at C-6 in the isoquinoline portion, and, thus, belong to the subclass of "Ancistrocladaceae-type" alkaloids.	Alkaloids	11-20	complement C3	Homo sapiens	41-44
30059720-3	2018	All of the alkaloids are S-configured at C-3 and possess an oxygen function at C-6 in the isoquinoline portion, and, thus, belong to the subclass of "Ancistrocladaceae-type" alkaloids.	Alkaloids	11-20	complement C6	Homo sapiens	79-82
30121232-6	2018	Furthermore, monoterpenoid 4 and alkaloid 15 showed remarkably inhibitory effect on the production of inflammatory mediator (NO) and pro-inflammatory cytokines (TNF-alpha and/or IL-6) in LPS-stimulated RAW264.7 cells.	Alkaloids	33-41	tumor necrosis factor	Mus musculus	161-170
30121232-6	2018	Furthermore, monoterpenoid 4 and alkaloid 15 showed remarkably inhibitory effect on the production of inflammatory mediator (NO) and pro-inflammatory cytokines (TNF-alpha and/or IL-6) in LPS-stimulated RAW264.7 cells.	Alkaloids	33-41	interleukin 6	Mus musculus	178-182
30243778-4	2018	As a result, alkaloids 1 and 2 exhibited cytotoxic activities (IC50 values <20 muM) against all tested tumor cell lines and significant antibacterial properties (MIC values from 0.12 to 0.26 mM).	Alkaloids	13-22	latexin	Homo sapiens	82-85
30009889-5	2018	Some natural products including polyphenols, terpenoids and alkaloids can induce Nrf2 expression as a key protein in the antioxidant defense system of hepatocytes.	Alkaloids	60-69	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
28978265-0	2018	Modulation of interaction of mutant TP53 and wild type BRCA1 by alkaloids: a computational approach towards targeting protein-protein interaction as a futuristic therapeutic intervention strategy for breast cancer impediment.	Alkaloids	64-73	tumor protein p53	Homo sapiens	36-40
28978265-0	2018	Modulation of interaction of mutant TP53 and wild type BRCA1 by alkaloids: a computational approach towards targeting protein-protein interaction as a futuristic therapeutic intervention strategy for breast cancer impediment.	Alkaloids	64-73	BRCA1 DNA repair associated	Homo sapiens	55-60
28978265-4	2018	Using computational approaches such as protein-protein docking, hot spot analyses, molecular docking and molecular dynamics simulation (MDS), stepwise analyses of the interactions of the wild type and mutant TP53 with that of wild type BRCA1 and their modulation by alkaloids were done.	Alkaloids	266-275	tumor protein p53	Homo sapiens	208-212
28978265-4	2018	Using computational approaches such as protein-protein docking, hot spot analyses, molecular docking and molecular dynamics simulation (MDS), stepwise analyses of the interactions of the wild type and mutant TP53 with that of wild type BRCA1 and their modulation by alkaloids were done.	Alkaloids	266-275	BRCA1 DNA repair associated	Homo sapiens	236-241
29729400-5	2018	Motherwort total alkaloids significantly increased angiogenesis in transgenic Tg (flk1: EGFP) zebrafish embryos treated with sunitinib, as did stachydrine, the most abundant alkaloid produced by motherwort.	Alkaloids	17-26	kinase insert domain receptor (a type III receptor tyrosine kinase)	Danio rerio	82-86
30200334-4	2018	The involvement of the Delta 1 -piperideine dimerization has been proposed for some of the Lys-derived alkaloid biosyntheses, but no enzymes for this dimerization reaction have been reported to date; moreover, it is not clear whether this dimerization reaction proceeds spontaneously or enzymatically.	Alkaloids	103-111	delta like non-canonical Notch ligand 1	Homo sapiens	23-30
30008816-1	2018	The present study aimed to investigate the effect of alkaloids and carbinol extracts from lily on the proliferation of SGC-7901 cells, as well as the underlying mechanism.	Alkaloids	53-62	sarcoglycan beta	Homo sapiens	119-122
30008816-2	2018	SGC-7901 cells were incubated with different concentrations of alkaloid or carbinol extracts for 24, 48 or 72 h. MTT assays were used to measure the inhibition rate of SGC-7901 cell proliferation.	Alkaloids	63-71	sarcoglycan beta	Homo sapiens	168-171
30008816-7	2018	Treatment with alkaloid or carbinol extracts deteriorated the morphology of SGC-7901 cells in a dose-dependent manner.	Alkaloids	15-23	sarcoglycan beta	Homo sapiens	76-79
30008816-8	2018	Alkaloid and carbinol extracts arrested SGC-7901 cells in the G2/M phase, and induced apoptosis in a dose-dependent manner.	Alkaloids	0-8	sarcoglycan beta	Homo sapiens	40-43
30008816-9	2018	Alkaloid and carbinol extracts enhanced caspase-3, and Fas expression, but reduced FasL expression in SGC-7901 cells.	Alkaloids	0-8	caspase 3	Homo sapiens	40-49
30008816-9	2018	Alkaloid and carbinol extracts enhanced caspase-3, and Fas expression, but reduced FasL expression in SGC-7901 cells.	Alkaloids	0-8	Fas ligand	Homo sapiens	83-87
30008816-9	2018	Alkaloid and carbinol extracts enhanced caspase-3, and Fas expression, but reduced FasL expression in SGC-7901 cells.	Alkaloids	0-8	sarcoglycan beta	Homo sapiens	102-105
30008816-10	2018	The present study demonstrated that alkaloids and carbinol extracts from lily inhibited the proliferation of gastric carcinoma SGC-7901 cells by arresting cells in the G2/M phase.	Alkaloids	36-45	sarcoglycan beta	Homo sapiens	127-130
29613805-0	2018	Tin-Free Access to the ABC Core of the Calyciphylline A Alkaloids and Unexpected Formation of a D-Ring-Contracted Tetracyclic Core.	Alkaloids	56-65	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	23-26
29156968-4	2018	As a result, alkaloids 1, 2, and 4 exhibited cytotoxicities against all the five tested tumor cell lines with IC50 value of less than 20 muM.	Alkaloids	13-22	latexin	Homo sapiens	137-140
29733650-2	2018	A pivotal step includes an intermolecular Michael addition of an indole-2-acetic acid methyl ester enolate to an alpha,beta-unsaturated N-sulfonyllactam to form the C15, C16 bond of the alkaloids.	Alkaloids	186-195	placenta associated 8	Homo sapiens	165-168
29277460-12	2018	Additionally, these alkaloids promoted the translocation of Nrf2 from the cytoplasm to the nucleus and significantly increased ARE-luciferin activity in HepG2-C8 cells.	Alkaloids	20-29	NFE2 like bZIP transcription factor 2	Homo sapiens	60-64
29438749-3	2018	In the present study, we found that the total alkaloids of D. crepidatum (TAD) can inhibit the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated macrophages and showed protective effects against LPS-induced acute lung injury (ALI) in mice through downregulating the TLR4-mediated MyD88/MAPK signaling pathway.	Alkaloids	46-55	toll-like receptor 4	Mus musculus	286-290
29438749-3	2018	In the present study, we found that the total alkaloids of D. crepidatum (TAD) can inhibit the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated macrophages and showed protective effects against LPS-induced acute lung injury (ALI) in mice through downregulating the TLR4-mediated MyD88/MAPK signaling pathway.	Alkaloids	46-55	myeloid differentiation primary response gene 88	Mus musculus	300-305
29438749-7	2018	Taken together, indolizine-type alkaloids are the active components of D. crepidatum through downregulating the TLR4-mediated pathway, indicating some kind of therapy of TAD for ALI treatment.	Alkaloids	32-41	toll-like receptor 4	Mus musculus	112-116
29674970-2	2018	N,N-Dimethyltryptamine (DMT, one of the alkaloids in Ayahuasca) activates sigma 1 receptor (SIGMAR1) and others.	Alkaloids	40-49	sigma non-opioid intracellular receptor 1	Homo sapiens	92-99
29524520-0	2018	The tumor antagonistic steroidal alkaloid Solanidine prompts the intrinsic suicidal signal mediated DFF-40 nuclear import and nucleosomal disruption.	Alkaloids	33-41	DNA fragmentation factor, beta subunit	Mus musculus	100-106
29498663-2	2018	We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum, respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters.	Alkaloids	47-56	ATP binding cassette subfamily B member 1	Homo sapiens	236-250
29044986-0	2018	Spectroscopic investigation of the anticancer alkaloid piperlongumine binding to human serum albumin from the viewpoint of drug delivery.	Alkaloids	46-54	albumin	Homo sapiens	87-100
29498663-2	2018	We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum, respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters.	Alkaloids	47-56	ATP binding cassette subfamily B member 1	Homo sapiens	252-256
29498663-2	2018	We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum, respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters.	Alkaloids	47-56	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	268-271
29498663-4	2018	Furthermore, rhodamine (Rho) 123 and calcein-AM were used to detect the effects of alkaloids on the activity of P-gp.	Alkaloids	83-92	ATP binding cassette subfamily B member 1	Homo sapiens	112-116
29428604-6	2018	Low (non-Homeopathic) doses of this plant or its alkaloids decrease neuropathic pain and c-Fos expression in mice brain and oxidative stress.	Alkaloids	49-58	FBJ osteosarcoma oncogene	Mus musculus	89-94
29386467-0	2018	Alkaloids from Stephania venosa as Chemo-Sensitizers in SKOV3 Ovarian Cancer Cells via Akt/NF-kappaB Signaling.	Alkaloids	0-9	AKT serine/threonine kinase 1	Homo sapiens	87-90
29386467-0	2018	Alkaloids from Stephania venosa as Chemo-Sensitizers in SKOV3 Ovarian Cancer Cells via Akt/NF-kappaB Signaling.	Alkaloids	0-9	nuclear factor kappa B subunit 1	Homo sapiens	91-100
28059041-6	2018	In conclusion, this kind of alkaloids has extensive antitumor activity, and there are several main mechanisms of their antitumor activity, including the Hedgehog signaling pathway, caspase-3 dependent apoptosis, cell cycle, and autophagy.	Alkaloids	28-37	caspase 3	Homo sapiens	181-190
28059042-4	2018	Alkaloids are a diverse group of naturally occurring compounds which have shown great COX-2 inhibitory activity both in vitro and in vivo.	Alkaloids	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	86-91
28059042-5	2018	In this mini-review, we have discussed different alkaloids with COX-2 inhibitory activities and anticancer potential which may act as leads in modern anticancer drug discovery.	Alkaloids	49-58	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-69
28059043-5	2018	In this review, the therapeutic potentials of plant derived natural products belonging to secondary metabolites, namely alkaloids, flavonoids and terpenoids as anticancer molecules, involving various strategies of treatment, have been discussed with special reference to topoisomerases (Topo), cyclooxygenases (COX), lipoxygenase (LOX) and aromatase as enzymatic targets for various types of cancers.	Alkaloids	120-129	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	340-349
28877378-5	2018	METHODOLOGY: Based upon previous structure elucidation studies, four alkaloids targeted in this study were identified using high resolution mass spectrometry by direct infusion of plant extracts, and their distributions were imaged by DESI-MSI via tissue imprints on a porous Teflon surface.	Alkaloids	69-78	RB binding protein 4, chromatin remodeling factor	Homo sapiens	240-243
29285198-0	2018	Total alkaloids of Corydalis saxicola bunting inhibits migration of A549 cells by suppressing Cdc42 or Vav1.	Alkaloids	6-15	cell division cycle 42	Homo sapiens	94-99
29285198-0	2018	Total alkaloids of Corydalis saxicola bunting inhibits migration of A549 cells by suppressing Cdc42 or Vav1.	Alkaloids	6-15	vav guanine nucleotide exchange factor 1	Homo sapiens	103-107
29257065-7	2017	Intake of DM did not differ (p = 0.91) among diets, although lambs fed 2447 ppb alkaloids had a lower (p < 0.01) ADG than did lambs receiving other treatments.	Alkaloids	80-89	ADG	Ovis aries	116-119
30178271-10	2018	Several new polymeric alkaloids were found to lack cytotoxicity against a number of human cancer cell lines, although two of them showed moderate aphicidal activity and one exhibited weak to moderate acetylcholinesterase inhibition.	Alkaloids	22-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	200-220
29992112-6	2018	Jurkat cells treated with alkaloids extract at sub-lethal concentration showed DNA fragmentation, enhancement in caspase-3 activity and phosphatidylserine translocation (apoptosis indicator) compared to control cells.	Alkaloids	26-35	caspase 3	Homo sapiens	113-122
29197828-0	2017	Matrine-Type Alkaloids Inhibit Advanced Glycation End Products Induced Reactive Oxygen Species-Mediated Apoptosis of Aortic Endothelial Cells In Vivo and In Vitro by Targeting MKK3 and p38MAPK Signaling.	Alkaloids	13-22	mitogen activated protein kinase kinase 3	Rattus norvegicus	176-180
29197828-8	2017	Matrine-type alkaloids suppressed intracellular reactive oxygen species production and inhibited endothelial cell apoptosis in vivo and in vitro by recovering phosphorylation of MKK3/6 and p38 MAPK, nuclear factor erythroid 2-related factor 2 nuclear translocation, and antioxidant response element binding activity, as well as the expression levels of heme oxygenase/NADPH quinone oxidoreductase.	Alkaloids	13-22	mitogen activated protein kinase kinase 3	Rattus norvegicus	178-184
29197828-8	2017	Matrine-type alkaloids suppressed intracellular reactive oxygen species production and inhibited endothelial cell apoptosis in vivo and in vitro by recovering phosphorylation of MKK3/6 and p38 MAPK, nuclear factor erythroid 2-related factor 2 nuclear translocation, and antioxidant response element binding activity, as well as the expression levels of heme oxygenase/NADPH quinone oxidoreductase.	Alkaloids	13-22	NFE2 like bZIP transcription factor 2	Rattus norvegicus	189-242
29197828-8	2017	Matrine-type alkaloids suppressed intracellular reactive oxygen species production and inhibited endothelial cell apoptosis in vivo and in vitro by recovering phosphorylation of MKK3/6 and p38 MAPK, nuclear factor erythroid 2-related factor 2 nuclear translocation, and antioxidant response element binding activity, as well as the expression levels of heme oxygenase/NADPH quinone oxidoreductase.	Alkaloids	13-22	crystallin zeta	Rattus norvegicus	374-396
29197828-9	2017	p38 MAPK inhibitor treatment impaired the effects of matrine-type alkaloids in vivo and in vitro.	Alkaloids	66-75	mitogen activated protein kinase 14	Rattus norvegicus	0-3
29197828-10	2017	MKK3/6 silencing impaired the effects of matrine-type alkaloids in vitro.	Alkaloids	54-63	mitogen activated protein kinase kinase 3	Rattus norvegicus	0-4
29197828-11	2017	CONCLUSIONS: Matrine-type alkaloids exert endothelial protective effects against advanced glycation end products induced reactive oxygen species-mediated apoptosis by targeting MKK3/6 and enhancing their phosphorylation.	Alkaloids	26-35	mitogen activated protein kinase kinase 3	Rattus norvegicus	177-181
28801761-5	2017	The alkaloid was able to inhibit the peritonitis induced by carrageenan, decreasing mainly the migration of polymorphonuclear cells, without altering the mononuclear cell number, and reduced the levels of TNF-alpha and IL-1beta in the peritoneum.	Alkaloids	4-12	tumor necrosis factor	Homo sapiens	205-214
28801761-5	2017	The alkaloid was able to inhibit the peritonitis induced by carrageenan, decreasing mainly the migration of polymorphonuclear cells, without altering the mononuclear cell number, and reduced the levels of TNF-alpha and IL-1beta in the peritoneum.	Alkaloids	4-12	interleukin 1 beta	Homo sapiens	219-227
27977936-16	2017	Importantly, the potent inhibition of hOCT2 by beta-carbolines also raises the concern of potential drug interactions between naturally occurring bioactive alkaloids and drugs eliminated by hOCT2.	Alkaloids	156-165	solute carrier family 22 member 2	Homo sapiens	38-43
29172693-4	2017	Therefore, the main aim of this work is to experimentally determine whether these alkaloids are DPP-IV inhibitors.	Alkaloids	82-91	dipeptidyl peptidase 4	Homo sapiens	96-102
29172693-5	2017	Materials & methods: The DPP-IV inhibition of Ephedra"s alkaloids was determined via a competitive-binding assay.	Alkaloids	60-69	dipeptidyl peptidase 4	Homo sapiens	29-35
29172693-8	2017	CONCLUSION: Further computational analysis shows how Ephedra"s alkaloids could be used as promising lead molecules for designing more potent and selective DPP-IV inhibitors.	Alkaloids	63-72	dipeptidyl peptidase 4	Homo sapiens	155-161
28497342-0	2017	Exploration of the Acetylcholinesterase Inhibitory Activity of Some Alkaloids from Amaryllidaceae Family by Molecular Docking In Silico.	Alkaloids	68-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	19-39
28899501-10	2017	The P-gp functional studies showed that these three alkaloids increased the accumulation of P-gp substrates, calcein-AM (C-AM) and rhodamine123 (Rho 123) in K562/Adr cells, while this effect was not seen in drug sensitive parental K562 cells.	Alkaloids	52-61	phosphoglycolate phosphatase	Homo sapiens	4-8
28899501-10	2017	The P-gp functional studies showed that these three alkaloids increased the accumulation of P-gp substrates, calcein-AM (C-AM) and rhodamine123 (Rho 123) in K562/Adr cells, while this effect was not seen in drug sensitive parental K562 cells.	Alkaloids	52-61	phosphoglycolate phosphatase	Homo sapiens	92-96
28899501-12	2017	CONCLUSION: The alkaloids reversed MDR via the inhibition of P-gp function.	Alkaloids	16-25	phosphoglycolate phosphatase	Homo sapiens	61-65
28858498-1	2017	The secondary metabolites that comprise the diterpenoid alkaloids are categorized into C18, C19, and C20 families depending on the number of contiguous carbon atoms that constitute their central framework.	Alkaloids	56-65	Bardet-Biedl syndrome 9	Homo sapiens	87-90
28497342-6	2017	In this context, the purpose of this study was to apply the docking molecular in silico analysis aiming to examine the recombinant human AChE enzyme (rhAChE) inhibitory activity displayed by different alkaloids from Amaryllidaceae family.	Alkaloids	201-210	acetylcholinesterase (Cartwright blood group)	Homo sapiens	137-141
28675836-0	2017	Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.	Alkaloids	8-17	phosphoglycolate phosphatase	Homo sapiens	21-25
28675836-7	2017	Apart from this, there exist a large number of natural alkaloids possessing potent inhibition of P-gp efflux pump and other related pumps responsible for the development of resistance.	Alkaloids	55-64	phosphoglycolate phosphatase	Homo sapiens	97-101
28675836-9	2017	The present review provides a comprehensive account on natural alkaloids possessing P-gp inhibition activity and their potential for multidrug resistance reversal in cancer.	Alkaloids	63-72	phosphoglycolate phosphatase	Homo sapiens	84-88
28696718-1	2017	A cross-metathesis protocol has been developed to provide facile access to highly hindered trisubstituted alpha-branched olefins, which when coupled with a cationic azaspirocyclization reaction, generates the marine alkaloids (-)-fasicularin 2 and a pro-forma synthesis of (-)-lepadiformine A 1.	Alkaloids	216-225	BCL2 related protein A1	Homo sapiens	291-294
28869563-8	2017	The representative putative targets of the alkaloids are inflammation-related proteins (MAPK14, PTGS2, PTGS2, and F2) and pruritus-related proteins (HRH1, TRPA1, HTR3A, and HTR6).	Alkaloids	43-52	mitogen-activated protein kinase 14	Homo sapiens	88-94
28869563-8	2017	The representative putative targets of the alkaloids are inflammation-related proteins (MAPK14, PTGS2, PTGS2, and F2) and pruritus-related proteins (HRH1, TRPA1, HTR3A, and HTR6).	Alkaloids	43-52	prostaglandin-endoperoxide synthase 2	Homo sapiens	96-101
28869563-8	2017	The representative putative targets of the alkaloids are inflammation-related proteins (MAPK14, PTGS2, PTGS2, and F2) and pruritus-related proteins (HRH1, TRPA1, HTR3A, and HTR6).	Alkaloids	43-52	prostaglandin-endoperoxide synthase 2	Homo sapiens	103-108
28869563-8	2017	The representative putative targets of the alkaloids are inflammation-related proteins (MAPK14, PTGS2, PTGS2, and F2) and pruritus-related proteins (HRH1, TRPA1, HTR3A, and HTR6).	Alkaloids	43-52	histamine receptor H1	Homo sapiens	149-153
28869563-8	2017	The representative putative targets of the alkaloids are inflammation-related proteins (MAPK14, PTGS2, PTGS2, and F2) and pruritus-related proteins (HRH1, TRPA1, HTR3A, and HTR6).	Alkaloids	43-52	transient receptor potential cation channel subfamily A member 1	Homo sapiens	155-160
28869563-8	2017	The representative putative targets of the alkaloids are inflammation-related proteins (MAPK14, PTGS2, PTGS2, and F2) and pruritus-related proteins (HRH1, TRPA1, HTR3A, and HTR6).	Alkaloids	43-52	5-hydroxytryptamine receptor 3A	Homo sapiens	162-167
28869563-8	2017	The representative putative targets of the alkaloids are inflammation-related proteins (MAPK14, PTGS2, PTGS2, and F2) and pruritus-related proteins (HRH1, TRPA1, HTR3A, and HTR6).	Alkaloids	43-52	5-hydroxytryptamine receptor 6	Homo sapiens	173-177
28644563-11	2017	Given that erythrinian alkaloids are applied in therapeutics and are promising leads for the development of new drugs, the present results could aid identification of several analogues of these alkaloids in biological samples and advance pharmacokinetic studies of new plant derivatives based on MSn and MS/MS analyses.	Alkaloids	23-32	moesin	Homo sapiens	296-299
29192437-6	2017	In this paper, the regulation effects of the main active substances of medicinal plants (such as polyphenols, saponins, and alkaloids) on p65 nuclear translocation and the upstream pathway of NF-kappaB were discussed, expecting to provide reference for the development of natural active substances for functional food.	Alkaloids	124-133	RELA proto-oncogene, NF-kB subunit	Homo sapiens	138-141
29192437-6	2017	In this paper, the regulation effects of the main active substances of medicinal plants (such as polyphenols, saponins, and alkaloids) on p65 nuclear translocation and the upstream pathway of NF-kappaB were discussed, expecting to provide reference for the development of natural active substances for functional food.	Alkaloids	124-133	nuclear factor kappa B subunit 1	Homo sapiens	192-201
28979070-5	2017	Besides, studies showed that phytochemicals such as flavonoids, alkaloids, terpenoids, anthocyanins, glycosides, and phenolic compounds possess significant inhibitory activity against alpha-glucosidase enzyme.	Alkaloids	64-73	sucrase-isomaltase	Homo sapiens	184-201
28479277-4	2017	Telomerase activity and mRNA levels of hTERT were estimated using quantitative telomere repeat amplification protocol (q-TRAP) and qPCR, in MCF-7 cells treated with different groups of alkaloids.	Alkaloids	185-194	telomerase reverse transcriptase	Homo sapiens	39-44
28853089-0	2017	Role of JAK1, JAK2, and JAK3 in Functional Stimulation of Mesenchymal Precursor Cells by Alkaloid Songorine.	Alkaloids	89-97	Janus kinase 1	Homo sapiens	8-12
28853089-0	2017	Role of JAK1, JAK2, and JAK3 in Functional Stimulation of Mesenchymal Precursor Cells by Alkaloid Songorine.	Alkaloids	89-97	Janus kinase 3	Homo sapiens	24-28
28708094-0	2017	Cholinesterase and Prolyl Oligopeptidase Inhibitory Activities of Alkaloids from Argemone platyceras (Papaveraceae).	Alkaloids	66-75	prolyl endopeptidase	Homo sapiens	19-40
28686226-5	2017	Both in vitro and in vivo, lipid-lowering alkaloid berberine (BBR) exhibited an anti-lymphoma activity through inhibiting MYC-driven downstream PCYT1A expression and inducing mitophagy-dependent necroptosis.	Alkaloids	42-50	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	122-125
28686226-5	2017	Both in vitro and in vivo, lipid-lowering alkaloid berberine (BBR) exhibited an anti-lymphoma activity through inhibiting MYC-driven downstream PCYT1A expression and inducing mitophagy-dependent necroptosis.	Alkaloids	42-50	phosphate cytidylyltransferase 1A, choline	Homo sapiens	144-150
27995747-0	2017	New 3-alkylpyridine marine alkaloid analogues as promising antitumor agents against the CD44+/high /CD24-/low subset of triple-negative breast cancer cell line.	Alkaloids	27-35	CD44 molecule (Indian blood group)	Homo sapiens	88-92
27995747-0	2017	New 3-alkylpyridine marine alkaloid analogues as promising antitumor agents against the CD44+/high /CD24-/low subset of triple-negative breast cancer cell line.	Alkaloids	27-35	CD24 molecule	Homo sapiens	100-104
28256030-9	2017	Results clearly demonstrated that QPT was not only involved in the biosynthetic pathway of the alkaloids but also affected plant growth and development.	Alkaloids	95-104	nicotinate-nucleotide pyrophosphorylase [carboxylating], chloroplastic-like	Nicotiana tabacum	34-37
28333079-4	2017	Monanchomycalin B is the most active among all published marine alkaloids (EC50 6.02, 2.84, and 3.25 muM for TRPV1, TRPV2, and TRPV3, correspondingly).	Alkaloids	64-73	latexin	Homo sapiens	101-104
28393571-4	2017	Consequently, alkaloids 2 and 3 exhibited cytotoxic activities for all tested tumor cell lines with IC50 values from 9.2 to 13.0 muM.	Alkaloids	14-23	latexin	Homo sapiens	129-132
28314480-3	2017	PURPOSE: To evaluate pharmacological effect of alkaloids from A. scholaris on ovalbumin induced airways allergic inflammatory model, and explore whether the dosing frequency is related to pharmacokinetics.	Alkaloids	47-56	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	78-87
28314480-14	2017	Then, an ovalbumin-provoked airways allergic inflammatory model indicated that the pharmacological effect of administration of total alkaloids 3 times a day was a little better than that of single dose daily.	Alkaloids	133-142	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	9-18
30108832-2	2017	The screen resulted in the identification of the natural product alkaloids, berberine and palmatine as well as alpha-tocopheryl succinate (alpha-TOS) as potential inhibitors of PTP1B.	Alkaloids	65-74	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	177-182
28257977-8	2017	Hypoglycemic effects of fruits and vegetables may be due to their inducing nature on pancreatic beta-cells for insulin secretion, or bioactive compounds such as flavonoids, alkaloids and anthocyanins, which act as insulin-like molecules or insulin secretagogues.	Alkaloids	173-182	insulin	Homo sapiens	214-221
27973724-0	2017	Investigations on Antioxidant, Antiproliferative and COX-2 Inhibitory Potential of Alkaloids from Anthocephalus cadamba (Roxb.)	Alkaloids	83-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
28333079-4	2017	Monanchomycalin B is the most active among all published marine alkaloids (EC50 6.02, 2.84, and 3.25 muM for TRPV1, TRPV2, and TRPV3, correspondingly).	Alkaloids	64-73	transient receptor potential cation channel subfamily V member 1	Homo sapiens	109-114
28333079-4	2017	Monanchomycalin B is the most active among all published marine alkaloids (EC50 6.02, 2.84, and 3.25 muM for TRPV1, TRPV2, and TRPV3, correspondingly).	Alkaloids	64-73	transient receptor potential cation channel subfamily V member 2	Homo sapiens	116-121
28333079-4	2017	Monanchomycalin B is the most active among all published marine alkaloids (EC50 6.02, 2.84, and 3.25 muM for TRPV1, TRPV2, and TRPV3, correspondingly).	Alkaloids	64-73	transient receptor potential cation channel subfamily V member 3	Homo sapiens	127-132
28333079-5	2017	Moreover, monanchomycalin B and urupocidin A are the first samples of marine alkaloids affecting the TRPV2 receptor.	Alkaloids	77-86	transient receptor potential cation channel subfamily V member 2	Homo sapiens	101-106
27903554-5	2017	The limit of detection for the described alkaloids was estimated at 0.122 mug mL-1.	Alkaloids	41-50	L1 cell adhesion molecule	Mus musculus	78-82
28208826-4	2017	The main effective components of Aconitum plants are diterpenoid alkaloids-which are divided into C18-, C19-, C20-, and bis-diterpenoid alkaloids-are reportedly some of the most promising, naturally abundant compounds for treating cancer.	Alkaloids	65-74	Bardet-Biedl syndrome 9	Homo sapiens	98-101
28185326-0	2017	Alkaloids from Piper nigrum Exhibit Antiinflammatory Activity via Activating the Nrf2/HO-1 Pathway.	Alkaloids	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	81-85
28185326-0	2017	Alkaloids from Piper nigrum Exhibit Antiinflammatory Activity via Activating the Nrf2/HO-1 Pathway.	Alkaloids	0-9	heme oxygenase 1	Mus musculus	86-90
26942689-3	2017	In the present study, plant-derived 300 anti-inflammatory and anti-cancerous secondary metabolites (100 each of alkaloids, flavonoids and terpenoids) have been screened for their pharmacokinetic properties and subsequently docked for identification of potent inhibitors of 5-LOX.	Alkaloids	112-121	lysyl oxidase	Homo sapiens	275-278
26942689-5	2017	Docking analyses of pharmacokinetically screened metabolites and their comparison with a known inhibitor (drug), namely zileuton revealed that only three alkaloids, six flavonoids and three terpenoids were found to dock successfully with 5-LOX with the flavonoid, velutin being the most potent inhibitor among all.	Alkaloids	154-163	lysyl oxidase	Homo sapiens	240-243
28952244-4	2017	This article would summarize the advances in research on drug metabolism and toxicology in domestic and foreign literature, and investigate the regulatory effects of different types of traditional Chinese medicine(TCM) ingredients(such as flavonoids, coumarins, alkaloids) on UGT1A1 expression and activity, including inhibitory effect of TCM chemical ingredients on UGT1A1 and effect of TCM chemical ingredients on UGT1A1.	Alkaloids	262-271	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	276-282
27648555-4	2017	The antiulcer effect of total alkaloids was evaluated using the ulcer area, the ulcer inhibition ratio, and epidermal growth factor.	Alkaloids	30-39	epidermal growth factor like 1	Rattus norvegicus	108-131
27648555-8	2017	Besides, the total alkaloids significantly increased the epidermal growth factor level and accelerated the healing of ulcers.	Alkaloids	19-28	epidermal growth factor like 1	Rattus norvegicus	57-80
27565766-4	2017	The results showed that the three alkaloids can form complexes with G-quadruplex KRAS promoter with the molecular ratio of 1:1, and the binding constants were (0.90+-0.16)x106Lmol-1, (0.93+-0.21)x106Lmol-1 and (1.16+-0.45)x106Lmol-1 for jatrorrhizine, berberine and sanguinarine.	Alkaloids	34-43	KRAS proto-oncogene, GTPase	Homo sapiens	81-85
27565766-8	2017	All the three alkaloids can bind with KRAS promoter G-quadruplex, and sanguinarine had the better binding property and antiproliferation effects on SW620 cells.	Alkaloids	14-23	KRAS proto-oncogene, GTPase	Homo sapiens	38-42
27686269-4	2016	The first phytochemical study of the plants was performed by standard procedures, while the AChE and MAO-A inhibition by fractions enriched in high MW alkaloids, was measured in vitro.	Alkaloids	151-160	monoamine oxidase A	Homo sapiens	101-106
27936793-1	2017	The illustrated azomethine ylide, produced through a Schiff base condensation of the corresponding aldehyde-containing C3a-arylhexahydroindole with ethyl l-leucinate, engages in a stereoselective intramolecular cycloaddition reaction to give adduct 23 that has been elaborated, over eight steps, into the racemic modification of the alkaloid derivative gracilamine (1).	Alkaloids	333-341	complement C3	Homo sapiens	119-122
28828994-5	2017	From this perspective, we applied ligand-based-virtual associated with structure-based-virtual screening of alkaloids from C. sympodialis Eichl and 101 derivatives proposed by us are promising leads against some important targets (BACE, GSK-3beta and MAO-A).	Alkaloids	108-117	beta-secretase 1	Homo sapiens	231-235
28828994-5	2017	From this perspective, we applied ligand-based-virtual associated with structure-based-virtual screening of alkaloids from C. sympodialis Eichl and 101 derivatives proposed by us are promising leads against some important targets (BACE, GSK-3beta and MAO-A).	Alkaloids	108-117	glycogen synthase kinase 3 alpha	Homo sapiens	237-246
28828994-5	2017	From this perspective, we applied ligand-based-virtual associated with structure-based-virtual screening of alkaloids from C. sympodialis Eichl and 101 derivatives proposed by us are promising leads against some important targets (BACE, GSK-3beta and MAO-A).	Alkaloids	108-117	monoamine oxidase A	Homo sapiens	251-256
27836488-4	2017	The results indicate that the seven alkaloids have similar interaction strengths with tamsulosin hydrochloride (alpha1A AR antagonist) between them and alpha1A AR.	Alkaloids	36-45	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	112-119
27836488-4	2017	The results indicate that the seven alkaloids have similar interaction strengths with tamsulosin hydrochloride (alpha1A AR antagonist) between them and alpha1A AR.	Alkaloids	36-45	adrenoceptor alpha 1A	Homo sapiens	112-122
28740333-0	2017	Mold Alkaloid Cytochalasin D Modifies the Morphology and Secretion of fMLP-, LPS-, or PMA-Stimulated Neutrophils upon Adhesion to Fibronectin.	Alkaloids	5-13	formyl peptide receptor 1	Homo sapiens	70-74
28740333-0	2017	Mold Alkaloid Cytochalasin D Modifies the Morphology and Secretion of fMLP-, LPS-, or PMA-Stimulated Neutrophils upon Adhesion to Fibronectin.	Alkaloids	5-13	fibronectin 1	Homo sapiens	130-141
28740333-3	2017	Invading pathogens produce alkaloids that cause the depolymerization of actin, such as the mold alkaloid cytochalasin D. We studied the effect of cytochalasin D on the morphology and secretion of fMLP-, LPS-, or PMA-stimulated human neutrophils upon adhesion to fibronectin.	Alkaloids	27-36	formyl peptide receptor 1	Homo sapiens	196-200
27287254-8	2016	The observed antihyperlipidemic effects of RC alkaloids can also be attributed to their action as agonists of FXR and TGR5, activators for SREBP2, LDLR, UCP2 and CYP7A1, inhibitors of HMGCR, TXNIP, TLR4 and JNK.	Alkaloids	46-55	nuclear receptor subfamily 1, group H, member 4	Mus musculus	110-113
28066324-0	2016	In Silico Study of Alkaloids as alpha-Glucosidase Inhibitors: Hope for the Discovery of Effective Lead Compounds.	Alkaloids	19-28	sucrase-isomaltase	Homo sapiens	32-49
28066324-6	2016	The molecular docking of 37 alkaloids along with standard acarbose and miglitol reported as a alpha-glucosidase inhibitor was performed via MOE-Dock implemented in MOE software to find the binding modes of these inhibitors.	Alkaloids	28-37	sucrase-isomaltase	Homo sapiens	94-111
27626463-3	2016	While this route does not provide the correct C10 stereochemistry, it showcases an efficient method to build analogues with the ring system of this class of alkaloids in 11 steps overall.	Alkaloids	157-166	homeobox C10	Homo sapiens	46-49
27624861-1	2016	Many natural terpenoid alkaloid conjugates show biological activity because their structures contain both sp3 -rich terpenoid scaffolds and nitrogen-containing alkaloid scaffolds.	Alkaloids	23-31	Sp3 transcription factor	Homo sapiens	106-109
27388056-8	2016	In forskolin-stimulated human hepatoma cells, these alkaloids suppressed the expression of a reporter gene under the control of cAMP response element and also prevented increases in the endogenous levels of phosphorylated CREB and PEPCK mRNA expression.	Alkaloids	52-61	cAMP responsive element binding protein 1	Homo sapiens	222-226
27388056-8	2016	In forskolin-stimulated human hepatoma cells, these alkaloids suppressed the expression of a reporter gene under the control of cAMP response element and also prevented increases in the endogenous levels of phosphorylated CREB and PEPCK mRNA expression.	Alkaloids	52-61	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	231-236
27287254-8	2016	The observed antihyperlipidemic effects of RC alkaloids can also be attributed to their action as agonists of FXR and TGR5, activators for SREBP2, LDLR, UCP2 and CYP7A1, inhibitors of HMGCR, TXNIP, TLR4 and JNK.	Alkaloids	46-55	G protein-coupled bile acid receptor 1	Mus musculus	118-122
27287254-8	2016	The observed antihyperlipidemic effects of RC alkaloids can also be attributed to their action as agonists of FXR and TGR5, activators for SREBP2, LDLR, UCP2 and CYP7A1, inhibitors of HMGCR, TXNIP, TLR4 and JNK.	Alkaloids	46-55	sterol regulatory element binding factor 2	Mus musculus	139-145
27287254-8	2016	The observed antihyperlipidemic effects of RC alkaloids can also be attributed to their action as agonists of FXR and TGR5, activators for SREBP2, LDLR, UCP2 and CYP7A1, inhibitors of HMGCR, TXNIP, TLR4 and JNK.	Alkaloids	46-55	low density lipoprotein receptor	Mus musculus	147-151
27287254-8	2016	The observed antihyperlipidemic effects of RC alkaloids can also be attributed to their action as agonists of FXR and TGR5, activators for SREBP2, LDLR, UCP2 and CYP7A1, inhibitors of HMGCR, TXNIP, TLR4 and JNK.	Alkaloids	46-55	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	153-157
27287254-8	2016	The observed antihyperlipidemic effects of RC alkaloids can also be attributed to their action as agonists of FXR and TGR5, activators for SREBP2, LDLR, UCP2 and CYP7A1, inhibitors of HMGCR, TXNIP, TLR4 and JNK.	Alkaloids	46-55	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	162-168
27287254-8	2016	The observed antihyperlipidemic effects of RC alkaloids can also be attributed to their action as agonists of FXR and TGR5, activators for SREBP2, LDLR, UCP2 and CYP7A1, inhibitors of HMGCR, TXNIP, TLR4 and JNK.	Alkaloids	46-55	thioredoxin interacting protein	Mus musculus	191-196
27287254-8	2016	The observed antihyperlipidemic effects of RC alkaloids can also be attributed to their action as agonists of FXR and TGR5, activators for SREBP2, LDLR, UCP2 and CYP7A1, inhibitors of HMGCR, TXNIP, TLR4 and JNK.	Alkaloids	46-55	toll-like receptor 4	Mus musculus	198-202
27287254-8	2016	The observed antihyperlipidemic effects of RC alkaloids can also be attributed to their action as agonists of FXR and TGR5, activators for SREBP2, LDLR, UCP2 and CYP7A1, inhibitors of HMGCR, TXNIP, TLR4 and JNK.	Alkaloids	46-55	mitogen-activated protein kinase 8	Mus musculus	207-210
27320660-1	2016	Ergot alkaloids in endophyte-infected grasses inhibit prolactin (PRL) secretion and may reduce milk production of cows consuming these grasses.	Alkaloids	6-15	prolactin	Bos taurus	65-68
27450719-2	2016	Consequently, the modulatory effect of alkaloid extracts from leaf and fruit of Jimson weed on critical enzymes of the purinergic [ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase), ecto-5"-nucleotidase (E-NTDase), alkaline phosphatase (ALP) and Na+/K+ ATPase] system of neurotransmission was the focus of this study.	Alkaloids	39-47	5' nucleotidase, ecto	Rattus norvegicus	192-212
27529730-2	2016	The key core of this alkaloid was constructed through a phosphoric acid promoted and highly stereocontrolled alkyne aza-Prins cyclization reaction, synchronously establishing the bridged B-ring and the C13 quaternary stereocenter.	Alkaloids	21-29	homeobox C13	Homo sapiens	202-205
27289446-0	2016	Structural and thermodynamic analysis of the binding of tRNA(phe) by the putative anticancer alkaloid chelerythrine: Spectroscopy, calorimetry and molecular docking studies.	Alkaloids	93-101	mitochondrially encoded tRNA glycine	Homo sapiens	56-65
27399232-0	2016	Alkaloids from the Fungus Penicillium spathulatum as alpha-Glucosidase Inhibitors.	Alkaloids	0-9	sucrase isomaltase (alpha-glucosidase)	Mus musculus	53-70
27289446-1	2016	The interaction of the putative anticancer alkaloid chelerythrine with tRNA(phe) was characterized by spectroscopy, calorimetry and molecular docking studies.	Alkaloids	43-51	mitochondrially encoded tRNA glycine	Homo sapiens	71-80
27259808-0	2016	Indolo-pyrido-isoquinolin based alkaloid inhibits growth, invasion and migration of breast cancer cells via activation of p53-miR34a axis.	Alkaloids	32-40	microRNA 34a	Homo sapiens	126-132
27259808-0	2016	Indolo-pyrido-isoquinolin based alkaloid inhibits growth, invasion and migration of breast cancer cells via activation of p53-miR34a axis.	Alkaloids	32-40	tumor protein p53	Homo sapiens	122-125
27428983-7	2016	Alkaloid 8 induced JNK1/2 (but not ERK1/2) activation leading to p53-independent cell death and strong suppression of AP-1 activity.	Alkaloids	0-8	mitogen-activated protein kinase 8	Homo sapiens	19-25
27428983-7	2016	Alkaloid 8 induced JNK1/2 (but not ERK1/2) activation leading to p53-independent cell death and strong suppression of AP-1 activity.	Alkaloids	0-8	tumor protein p53	Homo sapiens	65-68
27428983-8	2016	Alkaloids 1-4, 7, and 8 were able to inhibit the EGF-induced neoplastic transformation of JB6 P+ Cl41 cells.	Alkaloids	0-9	epidermal growth factor	Homo sapiens	49-52
27280693-3	2016	Only a few potent and selective ABCG2 inhibitors have been discovered, i.e., fumitremorgin C (FTC), Ko143, and the alkaloid harmine, which contain a tetrahydro-beta-carboline or beta-carboline backbone, respectively.	Alkaloids	115-123	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	32-37
27399665-5	2016	This review summarizes the research findings on marine natural products and derivatives, mainly alkaloids, polyoxygenated sterols, polyketides, terpenoids, diketopiperazines, and peptides, with P-gp inhibitory activity highlighting the established structure-activity relationships.	Alkaloids	96-105	ATP binding cassette subfamily B member 1	Homo sapiens	194-198
27161405-2	2016	These alkaloids have been found to possess apoptosis-inducing activity against tumor cells in vitro and in vivo mediated by nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and c-Jun N-terminal kinase (JNK) pathways, in which DNA damage and mitochondrial dysfunction play important roles.	Alkaloids	6-15	mitogen-activated protein kinase 8	Homo sapiens	203-226
27161405-2	2016	These alkaloids have been found to possess apoptosis-inducing activity against tumor cells in vitro and in vivo mediated by nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and c-Jun N-terminal kinase (JNK) pathways, in which DNA damage and mitochondrial dysfunction play important roles.	Alkaloids	6-15	mitogen-activated protein kinase 8	Homo sapiens	228-231
26918761-3	2016	Nine of these alkaloids (1-5, 8-11) showed pronounced in vitro growth inhibitory activity against human KB, PC-3, LNCaP, HCT 116, HT-29, MCF7, MDA-MB-231, and A549 cancer cells.	Alkaloids	14-23	chromobox 8	Homo sapiens	104-112
27478102-4	2016	The inhibitory activities on pancreatic lipase and preadipocyte proliferation for the synthesized compounds and alkaloids from Nulembo nucifera were assessed in vitro.	Alkaloids	112-121	pancreatic lipase	Homo sapiens	29-46
27126795-3	2016	In contrast, expression of two other key proteins required for alkaloid synthesis, quinolinic acid phosphoribosyltransferase (nicotinic acid production) and a PIP-family oxidoreductase (nicotinic acid condensation reactions), were diminished in roots of odc-RNAi plants relative to vector-only controls.	Alkaloids	63-71	ornithine decarboxylase	Nicotiana tabacum	254-257
27126795-4	2016	Transcriptional and biochemical differences associated with polyamine and alkaloid metabolism were exacerbated in odc-RNAi plants in response to different forms of shoot damage.	Alkaloids	74-82	ornithine decarboxylase	Nicotiana tabacum	114-117
27025413-2	2016	In this study, the naturally occurring dimeric alkaloid picrasidine N (1) from Picrasma quassioides was identified as a novel PPARbeta/delta agonist from a library consisting of plant extracts and natural compounds using a mammalian one-hybrid assay, and this compound was characterized.	Alkaloids	47-55	peroxisome proliferator activated receptor delta	Homo sapiens	126-134
26968518-5	2016	Soybean MATE family could be classified into four subfamilies comprising ten smaller subgroups, with diverse potential functions such as transport and accumulation of flavonoids or alkaloids, extrusion of plant-derived or xenobiotic compounds, regulation of disease resistance, and response to abiotic stresses.	Alkaloids	181-190	aluminum-activated citrate transporter	Glycine max	8-12
28879743-6	2016	Thymopolypeptides in this concentration range combined with 0.2 mmol L-1 matrine type alkaloids also had no toxicity to cells.	Alkaloids	86-95	immunoglobulin kappa variable 1-16	Homo sapiens	69-72
26666648-11	2016	The three alkaloids demonstrated minimal interaction with the drug efflux transporters Pgp and Bcrp, concordant with the ability of these alkaloids to cross the BBB.	Alkaloids	10-19	phosphoglycolate phosphatase	Rattus norvegicus	87-90
26616281-0	2016	Alkaloids derived from flowers of Senna spectabilis, (-)-cassine and (-)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression.	Alkaloids	0-9	mitogen-activated protein kinase 1	Homo sapiens	190-193
26616281-0	2016	Alkaloids derived from flowers of Senna spectabilis, (-)-cassine and (-)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression.	Alkaloids	0-9	cyclin D1	Homo sapiens	229-238
26829876-0	2016	Modular Total Syntheses of the Alkaloids Discoipyrroles A and B, Potent Inhibitors of the DDR2 Signaling Pathway.	Alkaloids	31-40	discoidin domain receptor tyrosine kinase 2	Homo sapiens	90-94
26740122-1	2016	Biochemical characterization of aromatic prenyltransferase AmbP1 and its close homologs WelP1/FidP1 in hapalindole-type alkaloid biosynthetic pathways is reported.	Alkaloids	120-128	complement factor H	Homo sapiens	59-64
27356778-4	2016	This review focuses on 32 alkaloids isolated from various plants that showed marked antibacterial activity against MRSA by acting through different mechanisms such as inhibition of pyruvate kinase, Quorum quenching effect, alteration in efflux pump in MRSA and intercalating of bacterial DNA, to name just a few.	Alkaloids	26-35	AT695_RS09030	Staphylococcus aureus	181-196
26876023-0	2016	GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway.	Alkaloids	46-55	ethylene-responsive transcription factor 1	Solanum lycopersicum	0-5
26615766-1	2016	ETHNOPHARMACOLOGICAL RELEVANCE: Extracts from and alkaloids contained in plants in the genus Sceletium have been reported to inhibit ligand binding to serotonin transporter.	Alkaloids	50-59	solute carrier family 6 member 4	Homo sapiens	151-172
26777309-6	2016	Pertinent plant alkaloids bearing alkyl, functionalized alkyl or alkenyl substituents include dendroprimine, anibamine, simple alkaloids belonging to the genera Prosopis, Elaeocarpus, Lycopodium, and Poranthera, and bicyclic alkaloids of the lupin family.	Alkaloids	16-25	5'-nucleotidase, cytosolic IIIA	Homo sapiens	242-247
26725433-9	2016	YKS and some alkaloids (corynoxeine: CX, geissoschizine methyl ether: GM) in Uncaria hook, a constituent herb of YKS, also inhibited COMT activity, indicating that the augmenting effect of YKS on L-DOPA-induced DA production in 5-HT synthetic cells was due to the inhibition of COMT by CX and GM.	Alkaloids	13-22	catechol-O-methyltransferase	Rattus norvegicus	133-137
26412505-4	2016	OBJECTIVE: To establish a high-performance liquid chromatography and tandem mass spectrometry (HPLC-MS/MS) method for the simultaneous analysis of 15 flavonoids, two phenolic acids and three alkaloids in Abri Herba and Abri mollis Herba.	Alkaloids	191-200	integral membrane protein 2B	Homo sapiens	204-208
26222678-4	2016	The alkaloids 1, 5, 12, 13 and the phenolic 2, 8, 11 tested compounds exhibited non-selective moderate cytotoxic activity with IC50 8.7-15.9 muM whereas compounds 3, 4, 6, 7, 9 and 10 showed low activity.	Alkaloids	4-13	latexin	Homo sapiens	141-144
31275002-5	2016	Here we performed a promoter assay using a heat shock protein gene (HSP17.6C-CI) of Arabidopsis to assess the induction of heat shock responses by alkaloids.	Alkaloids	147-156	heat shock protein	Arabidopsis thaliana	43-61
26134304-4	2016	This study was to elucidate the potential interaction of alkaloids (coptisine, jatrorrhizine, epiberberine, berberrubine, palmatine and corydaline) with OCTs using Madin-Darby canine kidney (MDCK) cells stably expressing human OCT1, OCT2 and OCT3.	Alkaloids	57-66	solute carrier family 22 member 1	Homo sapiens	227-231
26412505-0	2016	Simultaneous Detection of Flavonoids, Phenolic Acids and Alkaloids in Abri Herba and Abri Mollis Herba using Liquid Chromatography Tandem Mass Spectrometry.	Alkaloids	57-66	integral membrane protein 2B	Homo sapiens	70-74
26134304-4	2016	This study was to elucidate the potential interaction of alkaloids (coptisine, jatrorrhizine, epiberberine, berberrubine, palmatine and corydaline) with OCTs using Madin-Darby canine kidney (MDCK) cells stably expressing human OCT1, OCT2 and OCT3.	Alkaloids	57-66	solute carrier family 22 member 2	Homo sapiens	233-237
26134304-4	2016	This study was to elucidate the potential interaction of alkaloids (coptisine, jatrorrhizine, epiberberine, berberrubine, palmatine and corydaline) with OCTs using Madin-Darby canine kidney (MDCK) cells stably expressing human OCT1, OCT2 and OCT3.	Alkaloids	57-66	solute carrier family 22 member 3	Homo sapiens	242-246
26134304-10	2016	The above data indicate that the tested alkaloids are potent inhibitors, and coptisine, jatrorrhizine, epiberberine and berberrubine are substrates of hOCT1, hOCT2 and/or hOCT3 with high affinity.	Alkaloids	40-49	solute carrier family 22 member 1	Homo sapiens	151-156
26134304-10	2016	The above data indicate that the tested alkaloids are potent inhibitors, and coptisine, jatrorrhizine, epiberberine and berberrubine are substrates of hOCT1, hOCT2 and/or hOCT3 with high affinity.	Alkaloids	40-49	solute carrier family 22 member 2	Homo sapiens	158-163
26134304-10	2016	The above data indicate that the tested alkaloids are potent inhibitors, and coptisine, jatrorrhizine, epiberberine and berberrubine are substrates of hOCT1, hOCT2 and/or hOCT3 with high affinity.	Alkaloids	40-49	solute carrier family 22 member 3	Homo sapiens	171-176
26675722-8	2015	Specifically, it affords not only the targeted natural products, but also intermediates and derivatives in the three families of diterpenoid alkaloids (C-18, C-19 and C-20), and so provides a unified synthetic strategy for these natural products.	Alkaloids	141-150	Bardet-Biedl syndrome 9	Homo sapiens	152-156
26695288-7	2016	Finally, the application of C18-DTT column was demonstrated in the separation of non-steroidal anti-inflammatory drugs, aromatic carboxylic acids, alkaloids, nucleo-analytes and polycyclic aromatic hydrocarbons.	Alkaloids	147-156	Bardet-Biedl syndrome 9	Homo sapiens	28-31
26119076-1	2015	It has been reported that alkaloids derived from Coptis chinensis exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating peroxisome proliferation-activity receptor-gamma (PPAR-gamma) and CCAAT/enhancer binding protein-alpha (C/EBP-alpha).	Alkaloids	26-35	peroxisome proliferator activated receptor gamma	Homo sapiens	186-196
26119076-1	2015	It has been reported that alkaloids derived from Coptis chinensis exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating peroxisome proliferation-activity receptor-gamma (PPAR-gamma) and CCAAT/enhancer binding protein-alpha (C/EBP-alpha).	Alkaloids	26-35	CCAAT enhancer binding protein alpha	Homo sapiens	202-238
26119076-1	2015	It has been reported that alkaloids derived from Coptis chinensis exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating peroxisome proliferation-activity receptor-gamma (PPAR-gamma) and CCAAT/enhancer binding protein-alpha (C/EBP-alpha).	Alkaloids	26-35	CCAAT enhancer binding protein alpha	Homo sapiens	240-251
25687604-3	2015	Alkaloids 1 and 2 are voaphylline-vobasinyl type bisindole alkaloids, a structural type previously unknown, while 3-6 exhibited cytotoxicity against three human cancer cell lines HeLa, MCF-7, and SW480 with IC50 values ranging from 1.42 to 11.35 muM.	Alkaloids	0-9	latexin	Homo sapiens	246-249
26400396-5	2015	The IC50 values of the alkaloids ranged from 0.11 to 210 microM, and 42 of the alkaloids were confirmed to be time-dependent inhibitors of CYP2C19.	Alkaloids	23-32	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	139-146
26400396-5	2015	The IC50 values of the alkaloids ranged from 0.11 to 210 microM, and 42 of the alkaloids were confirmed to be time-dependent inhibitors of CYP2C19.	Alkaloids	79-88	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	139-146
26481525-10	2015	In particular, all of the alkaloids tested, with the exception of coptisine, inhibited TGF-beta1-induced collagen production.	Alkaloids	26-35	transforming growth factor beta 1	Homo sapiens	87-96
27141680-10	2015	Furthermore, the regulatory mechanism of alkaloids on the respiratory burst activity of macrophages may be also related to the expression level of PKC, p40phox and p47phox.	Alkaloids	41-50	neutrophil cytosolic factor 4	Mus musculus	152-159
27141680-10	2015	Furthermore, the regulatory mechanism of alkaloids on the respiratory burst activity of macrophages may be also related to the expression level of PKC, p40phox and p47phox.	Alkaloids	41-50	neutrophil cytosolic factor 1	Mus musculus	164-171
26529431-5	2015	In the present study almost 40 diverse phenolic compounds and alkaloids were examined for their ability to inhibit the recombinant AKR1B10 enzyme.	Alkaloids	62-71	aldo-keto reductase family 1 member B10	Homo sapiens	131-138
26640368-17	2015	Moreover, the mucoadhesive microspheres loaded with alkaloids reduce the inflammatory response by decreasing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), downregulating the mRNA expression of inducible nitric oxide synthase, TNF-alpha, and IL-1beta in gastric mucosa.	Alkaloids	52-61	tumor necrosis factor	Rattus norvegicus	123-150
26640368-17	2015	Moreover, the mucoadhesive microspheres loaded with alkaloids reduce the inflammatory response by decreasing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), downregulating the mRNA expression of inducible nitric oxide synthase, TNF-alpha, and IL-1beta in gastric mucosa.	Alkaloids	52-61	tumor necrosis factor	Rattus norvegicus	152-161
26640368-17	2015	Moreover, the mucoadhesive microspheres loaded with alkaloids reduce the inflammatory response by decreasing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), downregulating the mRNA expression of inducible nitric oxide synthase, TNF-alpha, and IL-1beta in gastric mucosa.	Alkaloids	52-61	interleukin 1 beta	Rattus norvegicus	164-181
26640368-17	2015	Moreover, the mucoadhesive microspheres loaded with alkaloids reduce the inflammatory response by decreasing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), downregulating the mRNA expression of inducible nitric oxide synthase, TNF-alpha, and IL-1beta in gastric mucosa.	Alkaloids	52-61	interleukin 1 beta	Rattus norvegicus	183-191
26640368-17	2015	Moreover, the mucoadhesive microspheres loaded with alkaloids reduce the inflammatory response by decreasing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), downregulating the mRNA expression of inducible nitric oxide synthase, TNF-alpha, and IL-1beta in gastric mucosa.	Alkaloids	52-61	tumor necrosis factor	Rattus norvegicus	265-274
26640368-17	2015	Moreover, the mucoadhesive microspheres loaded with alkaloids reduce the inflammatory response by decreasing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), downregulating the mRNA expression of inducible nitric oxide synthase, TNF-alpha, and IL-1beta in gastric mucosa.	Alkaloids	52-61	interleukin 1 beta	Rattus norvegicus	280-288
28339154-3	2015	Natural alkaloids, tetrandrine (TET), displayed different binding affinity with the three G-quadruplexes which may potentially regulate the expression of mir23b-27b-24-1 cluster members.	Alkaloids	8-17	microRNA 23b	Rattus norvegicus	154-160
26352530-13	2015	Among the four alkaloids, the permeability of BER was markedly higher than the others, and P-gp efflux had a significant effect on the absorption of those alkaloids.	Alkaloids	15-24	ATP binding cassette subfamily B member 1	Homo sapiens	91-95
26352530-13	2015	Among the four alkaloids, the permeability of BER was markedly higher than the others, and P-gp efflux had a significant effect on the absorption of those alkaloids.	Alkaloids	155-164	ATP binding cassette subfamily B member 1	Homo sapiens	91-95
27356391-7	2015	Total alkaloids of harmaline improved the neurons pathological changes of rat in the hippocampus CA1 area, 25 and 12.5 mg/kg of total alkaloids of harmaline downregulated the expression of apoptosis proteins BAX, upregulated the protein expression of BCL-2.	Alkaloids	6-15	carbonic anhydrase 1	Rattus norvegicus	97-100
27356391-7	2015	Total alkaloids of harmaline improved the neurons pathological changes of rat in the hippocampus CA1 area, 25 and 12.5 mg/kg of total alkaloids of harmaline downregulated the expression of apoptosis proteins BAX, upregulated the protein expression of BCL-2.	Alkaloids	6-15	BCL2 associated X, apoptosis regulator	Rattus norvegicus	208-211
27356391-7	2015	Total alkaloids of harmaline improved the neurons pathological changes of rat in the hippocampus CA1 area, 25 and 12.5 mg/kg of total alkaloids of harmaline downregulated the expression of apoptosis proteins BAX, upregulated the protein expression of BCL-2.	Alkaloids	6-15	BCL2, apoptosis regulator	Rattus norvegicus	251-256
27356391-7	2015	Total alkaloids of harmaline improved the neurons pathological changes of rat in the hippocampus CA1 area, 25 and 12.5 mg/kg of total alkaloids of harmaline downregulated the expression of apoptosis proteins BAX, upregulated the protein expression of BCL-2.	Alkaloids	134-143	BCL2 associated X, apoptosis regulator	Rattus norvegicus	208-211
27356391-7	2015	Total alkaloids of harmaline improved the neurons pathological changes of rat in the hippocampus CA1 area, 25 and 12.5 mg/kg of total alkaloids of harmaline downregulated the expression of apoptosis proteins BAX, upregulated the protein expression of BCL-2.	Alkaloids	134-143	BCL2, apoptosis regulator	Rattus norvegicus	251-256
26026497-2	2015	As part of our continuing search for natural inhibitors of the Hh/GLI1 signaling pathway, we isolated three alkaloids (1-3) from Crinum asiaticum.	Alkaloids	108-117	GLI family zinc finger 1	Homo sapiens	66-70
26669104-2	2015	The alkaloids were tested for their inhibition activity of human cholinesterases and prolyl oligopeptidase.	Alkaloids	4-13	prolyl endopeptidase	Homo sapiens	85-106
26307103-0	2015	Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine.	Alkaloids	87-95	ret proto-oncogene	Homo sapiens	24-27
25917462-5	2015	KEY RESULTS: The imidazole-based alkaloid derivative LCB54-0009 inhibited capillary-like tube formation in VEGF-induced HUVECs without inducing cytotoxic effects.	Alkaloids	33-41	vascular endothelial growth factor A	Rattus norvegicus	107-111
26272549-8	2015	Thus, Panax ginseng facilitated P-gp-mediated efflflux of toxic Aconitum carmichaeli alkaloids and restricted their intestinal absorption without inflfluencing other active components.	Alkaloids	85-94	phosphoglycolate phosphatase	Homo sapiens	32-36
25697484-4	2015	Both alkaloids increased the protein level of S139-phosphorylated H2AX (gammaH2AX), which however was independent of the induction of DNA damage.	Alkaloids	5-14	H2A.X variant histone	Homo sapiens	66-70
26156035-9	2015	Significantly greater cumulative amounts of NLC-associated LA and RAN than SLN-associated alkaloids penetrated the rat skin in vitro.	Alkaloids	90-99	sarcolipin	Rattus norvegicus	75-78
26156035-10	2015	In vivo microdialysis showed higher area under the concentration-time curve (AUC)0-t for AAS-NLC-associated LA and RAN than for AAS-SLN-associated alkaloids.	Alkaloids	147-156	sarcolipin	Rattus norvegicus	132-135
26035250-7	2015	Results showed pronounced differences in the content of hERG-blocking alkaloids ranging up to 992 mug (2) in the daily recommended dose.	Alkaloids	70-79	ETS transcription factor ERG	Homo sapiens	56-60
26028785-2	2015	We have shown that the ABC core of the calyciphylline A-type alkaloids can be rapidly accessed via the tandem cyclization of a neutral aminyl radical with a polarized cyclic olefin.	Alkaloids	61-70	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	23-26
25863351-4	2015	Promising results have been showed by alkaloids californidine (IC50=55.6+-3.5 muM), dihydrosanquinarine (IC50=99.1+-7.6 muM), corypalmine (IC50=128.0+-10.5 muM) and N-methyllaurotetanine (IC50=135.0+-11.7 muM).	Alkaloids	38-47	latexin	Homo sapiens	78-81
25937576-7	2015	The recombinant BmSUH was less sensitive to sugar-mimic alkaloids than TvSUH and ScSUH, which may explain the reason why the sucrase activity in the B. mori midgut was less affected by the sugar-mimic alkaloids derived from mulberry.	Alkaloids	56-65	maltase A1	Bombyx mori	16-21
25937576-7	2015	The recombinant BmSUH was less sensitive to sugar-mimic alkaloids than TvSUH and ScSUH, which may explain the reason why the sucrase activity in the B. mori midgut was less affected by the sugar-mimic alkaloids derived from mulberry.	Alkaloids	201-210	maltase A1	Bombyx mori	16-21
25695425-2	2015	The commercially available alkaloid boldine (2) was used as the starting material for synthesis of various C-9 alkoxy analogues of N-methyllaurotetanine in order to gauge the effect of C-9 alkylation on affinity and selectivity at 5-HT1A, 5-HT2A, and 5-HT7 receptors.	Alkaloids	27-35	complement C9	Homo sapiens	107-110
26033591-0	2015	Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine.	Alkaloids	102-110	mitogen-activated protein kinase 3	Homo sapiens	21-25
26033591-0	2015	Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine.	Alkaloids	102-110	mitogen-activated protein kinase 3	Homo sapiens	26-32
26033591-0	2015	Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine.	Alkaloids	102-110	mitogen-activated protein kinase 1	Homo sapiens	37-40
24947336-2	2015	A Nicotiana tabacum (tobacco) PUP-family transporter, nicotine uptake permease 1 (NtNUP1), was previously shown to transport tobacco alkaloids and to affect both nicotine biosynthesis and root growth in tobacco plants.	Alkaloids	133-142	purine permease 1-like	Nicotiana tabacum	54-80
25695425-2	2015	The commercially available alkaloid boldine (2) was used as the starting material for synthesis of various C-9 alkoxy analogues of N-methyllaurotetanine in order to gauge the effect of C-9 alkylation on affinity and selectivity at 5-HT1A, 5-HT2A, and 5-HT7 receptors.	Alkaloids	27-35	complement C9	Homo sapiens	185-188
25695425-2	2015	The commercially available alkaloid boldine (2) was used as the starting material for synthesis of various C-9 alkoxy analogues of N-methyllaurotetanine in order to gauge the effect of C-9 alkylation on affinity and selectivity at 5-HT1A, 5-HT2A, and 5-HT7 receptors.	Alkaloids	27-35	5-hydroxytryptamine receptor 1A	Homo sapiens	231-237
25695425-2	2015	The commercially available alkaloid boldine (2) was used as the starting material for synthesis of various C-9 alkoxy analogues of N-methyllaurotetanine in order to gauge the effect of C-9 alkylation on affinity and selectivity at 5-HT1A, 5-HT2A, and 5-HT7 receptors.	Alkaloids	27-35	5-hydroxytryptamine receptor 2A	Homo sapiens	241-245
25651456-5	2015	Similarly, according to the predicted binding orientation in the active site of the crystal structure of human CYP3A4 (PDB code: 4I4G ), the alkaloids were positioned in such a way that the C3 atom of lasiocarpine and retrorsine and the C26 of senkirkin were closest to the catalytic heme Fe.	Alkaloids	141-150	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	111-117
25735892-2	2015	Granulatimide and isogranulatimide are marine alkaloids that have been shown to inhibit checkpoint kinase 1 (Chk1), a key protein in the DNA damage response and an emerging target for anticancer therapeutics.	Alkaloids	46-55	checkpoint kinase 1	Homo sapiens	88-107
25790266-1	2015	The syn- and anti-diastereoisomeric forms of the reported structures of the marine alkaloids nakinadines D-F have been synthesized, for the first time in all cases, via an approach involving asymmetric Mannich-type (imino-aldol) reactions of methyl phenylacetate with N-tert-butylsulfinyl imines as the key steps to control the stereochemistry.	Alkaloids	83-92	synemin	Homo sapiens	4-7
25735892-2	2015	Granulatimide and isogranulatimide are marine alkaloids that have been shown to inhibit checkpoint kinase 1 (Chk1), a key protein in the DNA damage response and an emerging target for anticancer therapeutics.	Alkaloids	46-55	checkpoint kinase 1	Homo sapiens	109-113
25712523-0	2015	Quadruplex forming promoter region of c-myc oncogene as a potential target for a telomerase inhibitory plant alkaloid, chelerythrine.	Alkaloids	109-117	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	38-43
26084651-0	2015	Alkaloids from hydrastidis canadensis and their cholinesterase and prolyl oligopeptidase inhibitory.	Alkaloids	0-9	butyrylcholinesterase	Homo sapiens	48-62
26084651-0	2015	Alkaloids from hydrastidis canadensis and their cholinesterase and prolyl oligopeptidase inhibitory.	Alkaloids	0-9	prolyl endopeptidase	Homo sapiens	67-88
25596094-4	2015	As a result, alkaloids 1 and 4 exhibited significant cytotoxic activities against all tested tumor cell lines except against BEN-MEN-1.	Alkaloids	13-22	menin 1	Homo sapiens	129-134
25635954-1	2015	Described herein is a short total synthesis of alkaloid (-)-205B (1) by means of an anti-selective SN2" alkylation of an attractively functionalized cyclopropanol and diastereoselective cyclization of the resulting aminoallene adduct for bicyclic ring formation.	Alkaloids	47-55	solute carrier family 38 member 5	Homo sapiens	99-102
25547724-0	2014	Structure-based virtual screening of novel natural alkaloid derivatives as potential binders of h-telo and c-myc DNA G-quadruplex conformations.	Alkaloids	51-59	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	107-112
25529145-9	2015	The results suggest that the neuroprotective effects might be associated with lycorine and crinine-type alkaloids, whereas the acetylcholinesterase enzyme inhibitory activity could be related to galanthamine and lycorine-type alkaloids, although not based on synergistic processes.	Alkaloids	226-235	acetylcholinesterase	Rattus norvegicus	127-147
25636869-2	2015	All the alkaloids except for pumiloside (10) showed strong to weak BChE inhibitory effect with IC50 values ranging between 1.02-168.55 muM.	Alkaloids	8-17	butyrylcholinesterase	Homo sapiens	67-71
25378295-6	2015	The method was further applied in the synthesis of the lupin alkaloid cytisine.	Alkaloids	61-69	5'-nucleotidase, cytosolic IIIA	Homo sapiens	55-60
26075266-9	2015	We focus on representative phenolic derivatives, iridoid glycosides, terpenoids, alkaloids, and steroidal saponins as regulators of neurotrophin-mediated neuroprotection.	Alkaloids	81-90	brain derived neurotrophic factor	Homo sapiens	132-144
26059353-6	2015	Flavonoids, alkaloids, and xanthone compounds have been studied by various researchers (as inhibitory ligands in molecular docking; mainly with three enzymes: acetylcholinesterase (AChE; EC 3.1.1.7, butyrylcholinesterase (BChE; EC 3.1.1.8, and monoamine oxidase (MAO; EC 1.4.3.4.	Alkaloids	12-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	159-179
25481375-0	2015	Effects of Chelidonium majus extracts and major alkaloids on hERG potassium channels and on dog cardiac action potential - a safety approach.	Alkaloids	48-57	ETS transcription factor ERG	Homo sapiens	61-65
25280457-3	2015	An inhibitor of this pathway is the steroidal alkaloid cyclopamine, an antagonist of the Hh coreceptor Smoothened (SMO).	Alkaloids	46-54	smoothened, frizzled class receptor	Rattus norvegicus	103-113
25280457-3	2015	An inhibitor of this pathway is the steroidal alkaloid cyclopamine, an antagonist of the Hh coreceptor Smoothened (SMO).	Alkaloids	46-54	smoothened, frizzled class receptor	Rattus norvegicus	115-118
25344505-10	2014	Thus, NUP1 not only mediates the uptake of tobacco alkaloids into root cells, but also positively controls the expression of ERF189, a key gene in the biosynthesis of these alkaloids.	Alkaloids	51-60	ethylene-responsive transcription factor 13-like	Nicotiana tabacum	125-131
25344505-10	2014	Thus, NUP1 not only mediates the uptake of tobacco alkaloids into root cells, but also positively controls the expression of ERF189, a key gene in the biosynthesis of these alkaloids.	Alkaloids	173-182	ethylene-responsive transcription factor 13-like	Nicotiana tabacum	125-131
25354369-14	2014	This study advances our knowledge of the structural nature and thermodynamic aspects of binding between the putative anticancer alkaloid sanguinarine and lysozyme.	Alkaloids	128-136	lysozyme	Homo sapiens	154-162
24854538-4	2014	The antimalarial marine alkaloid malonganenone A was of particular interest, as it was found to have limited cytotoxicity to mammalian cell lines and exhibited the desired properties of an effective plasmodial Hsp70 modulator.	Alkaloids	24-32	heat shock protein family A (Hsp70) member 4	Homo sapiens	210-215
25047935-1	2014	The two marine alkaloids granulatimide and isogranulatimide have been shown to inhibit the checkpoint kinase 1 (Chk1), a promising target for cancer treatment.	Alkaloids	15-24	checkpoint kinase 1	Homo sapiens	91-110
25850276-12	2014	Compared with model group, Huanglian Jiedu decoction aqueous extract, total alkaloids and total iridoid could raise the expression of Cx43, and Huanglian Jiedu decoction aqueous extract could also increase the expression of GAD65 (P < 0.05).	Alkaloids	76-85	gap junction protein, alpha 1	Rattus norvegicus	134-138
25219605-2	2014	The purpose of this study was to investigate the in vitro effects of multiple extracts including aqueous extracts, total flavonoids, iridoids, alkaloids from HLJDD on the activities of CYPs in rats (CYP1A2, CYP2C6, CYP2D2, CYP2E1 and CYP3A1) and P-gp, and then to predict potential interactions with co-administered drugs.	Alkaloids	143-152	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	199-205
25219605-7	2014	Total alkaloids possessed similar inhibition on CYPs and could strongly inhibit the activity of CYP2D2 (IC50=2.38 mug/mL), CYP3A1 (IC50=2.61 mug/mL), CYP2E1 (IC50=22.35 mug/mL), CYP1A2 (IC50=23.2 mug/mL) and CYP2C6 (IC50=43.09 mug/mL).	Alkaloids	6-15	cytochrome P450, family 2, subfamily d, polypeptide 2	Rattus norvegicus	96-102
25219605-7	2014	Total alkaloids possessed similar inhibition on CYPs and could strongly inhibit the activity of CYP2D2 (IC50=2.38 mug/mL), CYP3A1 (IC50=2.61 mug/mL), CYP2E1 (IC50=22.35 mug/mL), CYP1A2 (IC50=23.2 mug/mL) and CYP2C6 (IC50=43.09 mug/mL).	Alkaloids	6-15	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	123-129
25219605-7	2014	Total alkaloids possessed similar inhibition on CYPs and could strongly inhibit the activity of CYP2D2 (IC50=2.38 mug/mL), CYP3A1 (IC50=2.61 mug/mL), CYP2E1 (IC50=22.35 mug/mL), CYP1A2 (IC50=23.2 mug/mL) and CYP2C6 (IC50=43.09 mug/mL).	Alkaloids	6-15	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	150-156
25219605-7	2014	Total alkaloids possessed similar inhibition on CYPs and could strongly inhibit the activity of CYP2D2 (IC50=2.38 mug/mL), CYP3A1 (IC50=2.61 mug/mL), CYP2E1 (IC50=22.35 mug/mL), CYP1A2 (IC50=23.2 mug/mL) and CYP2C6 (IC50=43.09 mug/mL).	Alkaloids	6-15	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	178-184
25219605-7	2014	Total alkaloids possessed similar inhibition on CYPs and could strongly inhibit the activity of CYP2D2 (IC50=2.38 mug/mL), CYP3A1 (IC50=2.61 mug/mL), CYP2E1 (IC50=22.35 mug/mL), CYP1A2 (IC50=23.2 mug/mL) and CYP2C6 (IC50=43.09 mug/mL).	Alkaloids	6-15	cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1	Rattus norvegicus	208-214
25219605-9	2014	Results from transport assay revealed that total flavonoids and alkaloids exhibited significant inhibitory effect on P-gp activity as evidenced by strong inhibition on the efflux of Rhodamine-123 with IC50 of 104.6 and 82.6 mug/mL.	Alkaloids	64-73	phosphoglycolate phosphatase	Rattus norvegicus	117-121
25219605-11	2014	CONCLUSIONS: This study clearly demonstrated that total flavonoids and alkaloids from HLJDD can significantly inhibit the activities of CYPs and P-gp, which should be taken into consideration to predict any potential HDIs when HLJDD and its bioactive components are co-administered with other therapeutic drugs metabolized by CYPs or transported by P-gp.	Alkaloids	71-80	phosphoglycolate phosphatase	Rattus norvegicus	145-149
25219605-11	2014	CONCLUSIONS: This study clearly demonstrated that total flavonoids and alkaloids from HLJDD can significantly inhibit the activities of CYPs and P-gp, which should be taken into consideration to predict any potential HDIs when HLJDD and its bioactive components are co-administered with other therapeutic drugs metabolized by CYPs or transported by P-gp.	Alkaloids	71-80	phosphoglycolate phosphatase	Rattus norvegicus	349-353
25314597-8	2014	The result suggests that the differences might be due to the presence of P-glycoprotein (P-gp) inhibitors and that other alkaloids co-existing in the EFY may compete with DHC for transportation by P-gp, metabolization by P450, and binding to plasma proteins.	Alkaloids	121-130	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	197-201
24975095-0	2014	Tetramethylpyrazine, a natural alkaloid, attenuates pro-inflammatory mediators induced by amyloid beta and interferon-gamma in rat brain microglia.	Alkaloids	31-39	interferon gamma	Rattus norvegicus	107-123
25128422-8	2014	In addition, the five alkaloids significantly reduced the expression levels of several adipocyte marker genes including proliferator activated receptor-gamma (PPAR-gamma) and CCAAT/enhancer-binding protein-alpha (C/EBP-alpha).	Alkaloids	22-31	peroxisome proliferator activated receptor gamma	Mus musculus	159-169
25128422-8	2014	In addition, the five alkaloids significantly reduced the expression levels of several adipocyte marker genes including proliferator activated receptor-gamma (PPAR-gamma) and CCAAT/enhancer-binding protein-alpha (C/EBP-alpha).	Alkaloids	22-31	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	175-211
25128422-8	2014	In addition, the five alkaloids significantly reduced the expression levels of several adipocyte marker genes including proliferator activated receptor-gamma (PPAR-gamma) and CCAAT/enhancer-binding protein-alpha (C/EBP-alpha).	Alkaloids	22-31	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	213-224
25128422-9	2014	In the present study, we found that the isolated alkaloids inhibited adipogenesis in a dose-dependent manner in 3T3-L1 cells; this inhibition was attributed to their abilities to downregulate the protein levels of the adipocyte marker proteins PPAR-gamma and C/EBP-alpha.	Alkaloids	49-58	peroxisome proliferator activated receptor gamma	Mus musculus	244-254
25128422-9	2014	In the present study, we found that the isolated alkaloids inhibited adipogenesis in a dose-dependent manner in 3T3-L1 cells; this inhibition was attributed to their abilities to downregulate the protein levels of the adipocyte marker proteins PPAR-gamma and C/EBP-alpha.	Alkaloids	49-58	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	259-270
25172799-0	2014	Alkaloids from Mahonia bealei posses anti-H+/K+-ATPase and anti-gastrin effects on pyloric ligation-induced gastric ulcer in rats.	Alkaloids	0-9	gastrin	Rattus norvegicus	64-71
25047935-1	2014	The two marine alkaloids granulatimide and isogranulatimide have been shown to inhibit the checkpoint kinase 1 (Chk1), a promising target for cancer treatment.	Alkaloids	15-24	checkpoint kinase 1	Homo sapiens	112-116
24905648-2	2014	The teratogenic action of some of these alkaloids is mediated by nicotinic acetylcholine receptors (nAChR).	Alkaloids	40-49	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	65-98
24363282-0	2014	Suppression of vascular endothelial growth factor via inactivation of eukaryotic elongation factor 2 by alkaloids in Coptidis rhizome in hepatocellular carcinoma.	Alkaloids	104-113	vascular endothelial growth factor A	Homo sapiens	15-49
24363282-0	2014	Suppression of vascular endothelial growth factor via inactivation of eukaryotic elongation factor 2 by alkaloids in Coptidis rhizome in hepatocellular carcinoma.	Alkaloids	104-113	eukaryotic translation elongation factor 2	Homo sapiens	70-100
24905648-2	2014	The teratogenic action of some of these alkaloids is mediated by nicotinic acetylcholine receptors (nAChR).	Alkaloids	40-49	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	100-105
24983126-1	2014	OBJECTIVE: Colchicine, a plant-derived alkaloid, is a known substrate for P-glycoprotein (Pgp), which confers multidrug resistance (MDR) to cancer cells and tumors, through enhanced efflux of chemotherapeutic drugs.	Alkaloids	39-47	ATP binding cassette subfamily B member 1	Homo sapiens	74-88
24983126-1	2014	OBJECTIVE: Colchicine, a plant-derived alkaloid, is a known substrate for P-glycoprotein (Pgp), which confers multidrug resistance (MDR) to cancer cells and tumors, through enhanced efflux of chemotherapeutic drugs.	Alkaloids	39-47	ATP binding cassette subfamily B member 1	Homo sapiens	90-93
24594217-8	2014	Moreover, total alkaloids decreased the production of the tumor necrosis factor alpha and nitric oxide in the serum and bronchoalveolar lavage fluid.	Alkaloids	16-25	tumor necrosis factor	Mus musculus	58-85
24981420-7	2014	These alkaloids, including liensinine, isoliensinine, dauricine and cepharanthine, stimulated AMPK-mTOR dependent induction of autophagy and autophagic cell death in a panel of apoptosis-resistant cells.	Alkaloids	6-15	mechanistic target of rapamycin kinase	Homo sapiens	99-103
24819955-0	2014	Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.	Alkaloids	107-115	butyrylcholinesterase	Homo sapiens	50-71
24594217-11	2014	This protective effect of total alkaloids seems to result from inhibition of nuclear factor kappa B activation, which causes the reduction of inflammatory markers such as tumor necrosis factor alpha and inducible nitric oxide synthase.	Alkaloids	32-41	tumor necrosis factor	Mus musculus	171-198
25272851-1	2014	To study the effects of alkaloids from Coptidis Rhizoma on low-density lipoprotein receptor (LDLR) mRNA expression and antihyperlipedemic levels.	Alkaloids	24-33	low-density lipoprotein receptor	Mesocricetus auratus	59-91
25272851-1	2014	To study the effects of alkaloids from Coptidis Rhizoma on low-density lipoprotein receptor (LDLR) mRNA expression and antihyperlipedemic levels.	Alkaloids	24-33	low-density lipoprotein receptor	Mesocricetus auratus	93-97
24561383-12	2014	CONCLUSION: The study revealed that the alkaloid compounds in lotus leaves exert a potent inhibitory effect on CYP2D6 isoenzyme.	Alkaloids	40-48	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	111-117
24606395-0	2014	Alkaloids from the roots of Stichoneuron caudatum and their acetylcholinesterase inhibitory activities.	Alkaloids	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-80
24673388-1	2014	An enantiocontrolled synthesis pathway has been developed to provide formation of tricyclic amine 7, representing the ABC ring system of the complex alkaloid daphnicyclidin A (1).	Alkaloids	149-157	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	118-121
24423447-2	2014	Although these alkaloids are believed to affect ryanodine receptor (RyR) gating in a "caffeine-like" manner, no single-channel study confirmed this assumption.	Alkaloids	15-24	ryanodine receptor 1	Homo sapiens	48-66
24423447-2	2014	Although these alkaloids are believed to affect ryanodine receptor (RyR) gating in a "caffeine-like" manner, no single-channel study confirmed this assumption.	Alkaloids	15-24	ryanodine receptor 1	Homo sapiens	68-71
24236461-4	2014	Among different phyto-constituents, alkaloids that contain isoquinoline/bis(isoquinoline)and related ring structures (such as berberine, palmatine, coptisine, and jateorrhizine) have shown very potent aldose reductase inhibitory activity.	Alkaloids	36-45	aldo-keto reductase family 1 member B	Homo sapiens	201-217
24236461-0	2014	Alkaloids as aldose reductase inhibitors, with special reference to berberine.	Alkaloids	0-9	aldo-keto reductase family 1 member B	Homo sapiens	13-29
24405813-3	2014	Molecular modeling of these alkaloids docked to a homology model of Pgp was employed to optimize ligand-protein interactions and design analogues with increased affinity to Pgp.	Alkaloids	28-37	ATP binding cassette subfamily B member 1	Homo sapiens	68-71
24405813-3	2014	Molecular modeling of these alkaloids docked to a homology model of Pgp was employed to optimize ligand-protein interactions and design analogues with increased affinity to Pgp.	Alkaloids	28-37	ATP binding cassette subfamily B member 1	Homo sapiens	173-176
24451589-3	2014	Here, we describe the construction of a screening library based on representative members of four families of biologically active alkaloids (Stemonaceae, the structurally related cyclindricine and lepadiformine families, lupin and Amaryllidaceae).	Alkaloids	130-139	5'-nucleotidase, cytosolic IIIA	Homo sapiens	221-226
24236461-7	2014	On the basis of these findings, it may be proposed that the presence of isoquinoline/bis(isoquinoline)ring structures is the most important requirement for alkaloids to behave as potent aldose reductase inhibitors.	Alkaloids	156-165	aldo-keto reductase family 1 member B	Homo sapiens	186-202
24236461-9	2014	The present review discusses these isoquinoline/bis(isoquinoline)-based alkaloids as aldose reductase inhibitors that may be used to manage diabetic complications and may substitute for the chemically synthesized aldose reductase inhibitors.	Alkaloids	72-81	aldo-keto reductase family 1 member B	Homo sapiens	85-101
24409339-2	2014	Our syntheses of these alkaloids feature an improved route to C3a-aminocyclotryptamines, an enhanced method for sulfamide synthesis and oxidation, in addition to a late-stage diversification leading to the first enantioselective total synthesis of (+)-desmethyl-meso-chimonanthine and its unambiguous stereochemical assignment.	Alkaloids	23-32	complement C3	Homo sapiens	62-65
24319990-2	2014	A pivotal step includes a novel intermolecular Michael-type addition of an indole ester dianion to a piperidine-derived nitrosoalkene to form the C15, C16 bond of the alkaloids.	Alkaloids	167-176	placenta associated 8	Homo sapiens	146-149
24328106-0	2014	Model studies directed toward the alkaloid mersicarpine utilizing a Rh(II)-catalyzed insertion/cycloaddition sequence.	Alkaloids	34-42	Rh blood group D antigen	Homo sapiens	68-73
25052035-0	2014	Knockdown of the NHR-8 nuclear receptor enhanced sensitivity to the lipid-reducing activity of alkaloids in Caenorhabditis elegans.	Alkaloids	95-104	Nuclear hormone receptor family member nhr-8	Caenorhabditis elegans	17-22
24083611-5	2014	According to their structural features, CYP1 inhibitors are divided into the following categories: flavonoids, trans-stilbenes, coumarins, terpenoids, alkaloids, quinones, isothiocyanates and synthetic aromatics.	Alkaloids	151-160	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	40-44
24484055-5	2014	The crude alkaloid extract had a weak inhibition potential of AChE with a lower IC50 (93 mug mL(-1)) than the methanolic extract (159 mug mL(-1)).	Alkaloids	10-18	acetylcholinesterase	Bos taurus	62-66
24529726-4	2014	Biochemical, molecular, and genetic studies have begun to reveal functions of a handful of ATP-binding cassette and multidrug and toxic compound extrusion family transporters engaged in transport of organic xenobiotics, heavy metals, metalloids, aluminum, alkaloids, flavonoids, terpenoids, terpenoid-derived phytohormones, cuticle lipids, and monolignols in plants.	Alkaloids	256-265	ATPase phospholipid transporting 8A2	Homo sapiens	91-94
23934400-7	2014	Ectopic overexpression of NtERF32 increases expression of NtPMT1a in vivo and elevates total alkaloid contents, whereas RNAi-mediated knockdown of NtERF32 reduces the mRNA levels of multiple genes in the nicotine biosynthetic pathway including NtPMT1a and quinolinate phosphoribosyltransferase (NtQPT2), and lowers nicotine and total alkaloid levels.	Alkaloids	93-101	ethylene-responsive transcription factor 2	Nicotiana tabacum	26-33
23982874-2	2014	We examined the plant alkaloid ellipticine for its efficacy to inhibit the expression of aldehyde dehydrogenase 1 class A1 (ALDH1A1)-positive BCSCs by in vitro and in silico methods.	Alkaloids	22-30	aldehyde dehydrogenase 1 family member A1	Homo sapiens	89-122
23982874-2	2014	We examined the plant alkaloid ellipticine for its efficacy to inhibit the expression of aldehyde dehydrogenase 1 class A1 (ALDH1A1)-positive BCSCs by in vitro and in silico methods.	Alkaloids	22-30	aldehyde dehydrogenase 1 family member A1	Homo sapiens	124-131
23999162-0	2013	Influence of combinations of digitonin with selected phenolics, terpenoids, and alkaloids on the expression and activity of P-glycoprotein in leukaemia and colon cancer cells.	Alkaloids	80-89	ATP binding cassette subfamily B member 1	Homo sapiens	124-138
24236981-4	2013	This review aims to summarize recent advances in current knowledge on alkaloids as AChE and BChE inhibitors, highlighting structure-activity relationship (SAR) and docking studies.	Alkaloids	70-79	butyrylcholinesterase	Homo sapiens	92-96
24236981-7	2013	Following this view, an increasing interest in achieving more potent and effective analogues makes alkaloids good chemical templates for the development of new cholinesterase inhibitors.	Alkaloids	99-108	acetylcholinesterase (Cartwright blood group)	Homo sapiens	160-174
24036064-11	2013	CONCLUSIONS: These results demonstrated that liensinine, neferine, and isoliensinine are substrates of P-gp, whereas MRP2 is not involved in the transport process, suggesting that P-gp might be responsible for the absorption and distribution of the 3 alkaloids.	Alkaloids	251-260	PGP	Canis lupus familiaris	103-107
24036064-11	2013	CONCLUSIONS: These results demonstrated that liensinine, neferine, and isoliensinine are substrates of P-gp, whereas MRP2 is not involved in the transport process, suggesting that P-gp might be responsible for the absorption and distribution of the 3 alkaloids.	Alkaloids	251-260	PGP	Canis lupus familiaris	180-184
24225772-15	2013	Moreover, Annexin-V/PI double staining and flow cytometry showed that the combination of alkaloids and triterpenes (1, 2 and 3 mg raw material/kg) could induce apoptosis and cause S cell cycle arrest in A549 cells.	Alkaloids	89-98	annexin A5	Mus musculus	10-19
23136954-6	2013	RESULTS: Among the alkaloids, lycorine (AA1), hippeastrine (AA2), hemanthamine (AA3) and 11-hydroxy vittatine (AA4) exhibited antiviral activities, with EC90 values of 0 52, 82 07, 4 15, and 13 45 mum, respectively.	Alkaloids	19-28	AA1	Homo sapiens	40-43
23136954-6	2013	RESULTS: Among the alkaloids, lycorine (AA1), hippeastrine (AA2), hemanthamine (AA3) and 11-hydroxy vittatine (AA4) exhibited antiviral activities, with EC90 values of 0 52, 82 07, 4 15, and 13 45 mum, respectively.	Alkaloids	19-28	AA2	Homo sapiens	60-63
23810408-6	2013	Stimulated mesenteric lymph node (MLN) cells in the presence of the alkaloids diminished the IL-12p70 levels independently of IFN-gamma or IL-13 secretion.	Alkaloids	68-77	interferon gamma	Mus musculus	126-135
23108405-0	2013	Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity.	Alkaloids	51-59	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
24502153-6	2013	These proteins may play roles in alkaloids biosynthesis via plant defense metabolism from the presumptions that chitosan might weaken the detoxifying function of glutathione S-transferase, then, heat shock protein is probably produced to signal for tissue protection mechanism.	Alkaloids	33-42	glutathione S-transferase kappa 1	Homo sapiens	162-187
23944995-2	2013	Alkaloids 1 and 2 are the first vobasinyl-ibogan-type alkaloids possessing a six-membered ring via an ether linkage between C-17 and C-21.	Alkaloids	0-9	cytokine like 1	Homo sapiens	124-128
23944995-2	2013	Alkaloids 1 and 2 are the first vobasinyl-ibogan-type alkaloids possessing a six-membered ring via an ether linkage between C-17 and C-21.	Alkaloids	0-9	TBL1X/Y related 1	Homo sapiens	133-137
23488788-0	2013	Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1).	Alkaloids	27-35	solute carrier family 36 member 1	Homo sapiens	60-99
23861794-0	2013	Plant derived aporphinic alkaloid S-(+)-dicentrine induces antinociceptive effect in both acute and chronic inflammatory pain models: evidence for a role of TRPA1 channels.	Alkaloids	25-33	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	157-162
23845551-6	2013	Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 mug mL-1 and CC50 values of 14.37, 4.79, and 80.12 mug mL-1, respectively.	Alkaloids	0-9	L1 cell adhesion molecule	Mus musculus	112-116
23845551-6	2013	Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 mug mL-1 and CC50 values of 14.37, 4.79, and 80.12 mug mL-1, respectively.	Alkaloids	0-9	L1 cell adhesion molecule	Mus musculus	163-167
23618192-2	2013	Applying this on-line method to the identification of BChE inhibitors in a Plumula nelumbinis sample, three alkaloids, namely liensinine, isoliensinine, and neferine, have been detected as having a strong BChE inhibition activity for the first time; in addition, norisoliensinine and 6-hydroxynorisoliensinine were proposed as two new compounds identified by their UV and MS data.	Alkaloids	108-117	butyrylcholinesterase	Homo sapiens	54-58
23618192-2	2013	Applying this on-line method to the identification of BChE inhibitors in a Plumula nelumbinis sample, three alkaloids, namely liensinine, isoliensinine, and neferine, have been detected as having a strong BChE inhibition activity for the first time; in addition, norisoliensinine and 6-hydroxynorisoliensinine were proposed as two new compounds identified by their UV and MS data.	Alkaloids	108-117	butyrylcholinesterase	Homo sapiens	205-209
23570516-1	2013	CONTEXT: A steroidal alkaloid, 4-acetoxy-plakinamine B (4APB), is a recently discovered marine natural product with inhibitory effect against acetylcholinesterase (AChE), but its mechanism of interaction with the enzyme remains to be elucidated.	Alkaloids	21-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-162
23570516-1	2013	CONTEXT: A steroidal alkaloid, 4-acetoxy-plakinamine B (4APB), is a recently discovered marine natural product with inhibitory effect against acetylcholinesterase (AChE), but its mechanism of interaction with the enzyme remains to be elucidated.	Alkaloids	21-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-168
23562757-0	2013	Alkaloids from Galipea longiflora Krause modify the maturation of human dendritic cells and their ability to stimulate allogeneic CD4+ T cells.	Alkaloids	0-9	CD4 molecule	Homo sapiens	130-133
23562757-4	2013	In this study the effect of an alkaloid extract of Evanta (AEE) or the purified alkaloid 2-phenilquinoline (2Ph) on the activation of human DCs and their ability to stimulate allogeneic CD4(+) T cells was analyzed.	Alkaloids	31-39	CD4 molecule	Homo sapiens	186-189
23488788-0	2013	Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1).	Alkaloids	27-35	solute carrier family 36 member 1	Homo sapiens	101-106
23411141-1	2013	While tailing and overloading of basic compounds remain problematic on most RP columns, a new kind of positively charged RP column named XCharge C18 was found to be superior good for the separation of alkaloids in our practical use.	Alkaloids	201-210	Bardet-Biedl syndrome 9	Homo sapiens	145-148
23395652-2	2013	The natural alkaloid (-)-huperzine A is a potent inhibitor of AChE and has been demonstrated to exert neuroprotection at an appropriate dose.	Alkaloids	12-20	acetylcholinesterase	Cavia porcellus	62-66
22734711-2	2013	In an attempt to find inhibitors for acetylcholinesterase (AChE), the Drug Bank Database and natural alkaloids with other known medicinal values were screened through a four-point pharmacophore built in this study.	Alkaloids	101-110	acetylcholinesterase (Cartwright blood group)	Homo sapiens	37-57
22734711-2	2013	In an attempt to find inhibitors for acetylcholinesterase (AChE), the Drug Bank Database and natural alkaloids with other known medicinal values were screened through a four-point pharmacophore built in this study.	Alkaloids	101-110	acetylcholinesterase (Cartwright blood group)	Homo sapiens	59-63
23322663-11	2013	The properties of these alkaloids revealed promising potentials to regulate the expression of the BCL2 protein from the posttranscriptional pathway.	Alkaloids	24-33	BCL2 apoptosis regulator	Homo sapiens	98-102
23292758-2	2013	The resulting amino-ketones underwent spontaneous intramolecular ring closure to afford Delta1-piperideines, which served as precursors for the cis- and anti-piperidine scaffold as demonstrated for the synthesis of the alkaloids dihydropinidine and epi-dihydropinidine.	Alkaloids	219-228	delta like non-canonical Notch ligand 1	Homo sapiens	88-94
23368752-2	2013	We report syntheses of amphimedosides A-C that feature a stereoselective oxyamine neoglycosylation and found that these alkaloids display modest cytotoxicity toward seven diverse human cancer cell lines, exhibiting IC(50) values ranging from 3.0 muM to greater than 100 muM.	Alkaloids	120-129	latexin	Homo sapiens	246-249
23238299-2	2013	This study demonstrates that chelidonine and an alkaloid extract from Chelidonium majus, which contains protoberberine and benzo[c]phenanthridine alkaloids, has the ability to overcome MDR of different cancer cell lines through interaction with ABC-transporters, CYP3A4 and GST, by induction of apoptosis, and cytotoxic effects.	Alkaloids	48-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	263-269
23238299-4	2013	In addition, chelidonine and the alkaloid extract inhibited the activity of the drug modifying enzymes CYP3A4 and GST in a dose-dependent manner.	Alkaloids	33-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	103-109
23238299-5	2013	The alkaloids induced apoptosis in MDR cells which was accompanied by an activation of caspase-3, -8,-6/9, and phosphatidyl serine (PS) exposure.	Alkaloids	4-13	caspase 3	Homo sapiens	87-96
23368752-2	2013	We report syntheses of amphimedosides A-C that feature a stereoselective oxyamine neoglycosylation and found that these alkaloids display modest cytotoxicity toward seven diverse human cancer cell lines, exhibiting IC(50) values ranging from 3.0 muM to greater than 100 muM.	Alkaloids	120-129	latexin	Homo sapiens	270-273
23513717-2	2013	The isolated alkaloids were tested for in vitro cytotoxic activities against two cell lines, C-6 (rat glioma cells) and CHO-K1 (Chinese hamster ovary cells).	Alkaloids	13-22	complement C6	Rattus norvegicus	93-96
23098900-5	2013	The anti-inflammatory activity of the crude extracts and the five alkaloids were tested by measuring the amount of TNF-alpha and IL-6 released from LPS stimulated RAW264 cell via ELISA.	Alkaloids	66-75	tumor necrosis factor	Mus musculus	115-124
23098900-5	2013	The anti-inflammatory activity of the crude extracts and the five alkaloids were tested by measuring the amount of TNF-alpha and IL-6 released from LPS stimulated RAW264 cell via ELISA.	Alkaloids	66-75	interleukin 6	Mus musculus	129-133
24317056-6	2013	Characterization of worms with knockdown nhr-49, a hormone nuclear receptor gene that functions as a key regulator of fat consumption, showed that both alkaloids were effective even in these markedly lipid-accumulating nhr-49 RNAi worms, suggesting that they predominantly affect lipid synthesis, rather than fatty acid beta-oxidation.	Alkaloids	152-161	NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-49	Caenorhabditis elegans	41-47
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	Alkaloids	41-49	phosphoglycolate phosphatase	Homo sapiens	149-153
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	Alkaloids	41-49	ATP binding cassette subfamily B member 1	Homo sapiens	154-158
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	Alkaloids	41-49	MDM4 regulator of p53	Homo sapiens	160-164
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	Alkaloids	41-49	BCR pseudogene 1	Homo sapiens	166-170
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	Alkaloids	41-49	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	172-178
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	Alkaloids	41-49	nuclear receptor subfamily 1 group I member 2	Homo sapiens	189-193
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	Alkaloids	41-49	caspase 3	Homo sapiens	227-236
23238299-8	2013	Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA.	Alkaloids	41-49	caspase 8	Homo sapiens	241-250
22968712-2	2013	A competitive binding assay using CHO membranes showed that GM (IC(50) = 0.034 muM) more strongly inhibited the binding of the radioligand [(3)H] LSD to 5-HT(7) receptor than the other alkaloids, suggesting that GM is bound to 5-HT(7) receptor.	Alkaloids	185-194	latexin	Homo sapiens	79-82
23931437-3	2013	Naturally occurring alkaloids are an important source of AChE inhibitors.	Alkaloids	20-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-61
24317056-6	2013	Characterization of worms with knockdown nhr-49, a hormone nuclear receptor gene that functions as a key regulator of fat consumption, showed that both alkaloids were effective even in these markedly lipid-accumulating nhr-49 RNAi worms, suggesting that they predominantly affect lipid synthesis, rather than fatty acid beta-oxidation.	Alkaloids	152-161	NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-49	Caenorhabditis elegans	219-225
22653963-5	2012	The alkaloids  significantly decreased (P < .05) the testes-body weight  ratio; the concentrations of testicular total protein, glycogen, sialic acid,  and cholesterol; and the activities of gamma-glutamyl transferase, acid  phosphatase, and alkaline phosphatase.	Alkaloids	4-13	gamma-glutamyltransferase 1	Rattus norvegicus	194-220
23063145-0	2012	Antihyperglycemic activity with DPP-IV inhibition of alkaloids from seed extract of Castanospermum australe: Investigation by experimental validation and molecular docking.	Alkaloids	53-62	dipeptidylpeptidase 4	Rattus norvegicus	32-38
23063145-7	2012	Molecular docking of the three reported alkaloids from the seeds of C. australe showed comparable DPP-IV inhibition with berberine.	Alkaloids	40-49	dipeptidylpeptidase 4	Rattus norvegicus	98-104
23063145-9	2012	The molecular docking showed that among the three alkaloids of seed extract 7-Deoxy-6-epi-castanospermine is a potent DPP-IV inhibitor similar to berberine.	Alkaloids	50-59	dipeptidylpeptidase 4	Rattus norvegicus	118-124
23002206-2	2012	Halofuginone is a plant alkaloid derivative that blocks TGF-beta signaling with antiangiogenic and antiproliferative properties.	Alkaloids	24-32	transforming growth factor, beta 1	Mus musculus	56-64
23058055-0	2012	In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids.	Alkaloids	108-117	PGP	Canis lupus familiaris	27-41
23058055-2	2012	The aim of the present study was to evaluate whether nine potentially CNS-active Amaryllidaceae alkaloids of the crinine, lycorine and galanthamine types interact with P-gp.	Alkaloids	96-105	PGP	Canis lupus familiaris	168-172
23067419-1	2012	The opioid receptor family is composed of three members, the micro, delta and kappa opioid receptors, that respond to classical opioid alkaloids such as morphine and heroin as well as endogenous peptide ligands like endorphins.	Alkaloids	135-144	opioid receptor kappa 1	Homo sapiens	61-100
23133418-7	2012	Several lines of evidence suggest that many of the reported sex differences related to cigarette smoking may stem from the inhibitory effects of nicotine and other tobacco alkaloids on estrogen synthesis via the enzyme aromatase (cyp19a gene product).	Alkaloids	172-181	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	219-228
22901310-3	2012	Anibamine, a novel pyridine quaternary alkaloid isolated from Aniba sp., was found to effectively compete with (125)I-gp120 in binding to the chemokine receptor CCR5, with an IC(50) = 1 muM.	Alkaloids	39-47	C-C motif chemokine receptor 5	Homo sapiens	161-165
22294283-1	2012	The inhibitory activity of Tinospora cordifolia stem-derived alkaloids was evaluated against lens aldose reductase (AR) isolated from male Wistar rats.	Alkaloids	61-70	aldo-keto reductase family 1 member B1	Rattus norvegicus	98-114
21827366-2	2012	The isolated alkaloids significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells.	Alkaloids	13-22	toll-like receptor 4	Mus musculus	99-102
22690724-1	2012	A stereochemically controlled route to the enantiopure [6-6-5-7] tetracyclic core of Calyciphylline A class alkaloids was established, which involves Overman rearrangement, [2 + 2] photochemical cycloaddition, Grob fragmentation, C-N bond-forming nucleophilic displacement, and ring strain-directed hydrogenation as strategic steps.	Alkaloids	108-117	C-X-C motif chemokine ligand 2	Homo sapiens	210-214
22592163-3	2012	This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10.	Alkaloids	43-52	tumor necrosis factor	Homo sapiens	135-144
22592163-3	2012	This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10.	Alkaloids	43-52	C-C motif chemokine ligand 2	Homo sapiens	147-181
22592163-3	2012	This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10.	Alkaloids	43-52	C-C motif chemokine ligand 2	Homo sapiens	183-188
22592163-3	2012	This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10.	Alkaloids	43-52	C-C motif chemokine ligand 2	Homo sapiens	204-209
22592163-3	2012	This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10.	Alkaloids	43-52	interleukin 6	Homo sapiens	212-230
22592163-3	2012	This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10.	Alkaloids	43-52	interleukin 1 beta	Homo sapiens	232-240
22592163-3	2012	This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10.	Alkaloids	43-52	interleukin 1 receptor antagonist	Homo sapiens	273-297
22592163-3	2012	This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10.	Alkaloids	43-52	interleukin 1 receptor antagonist	Homo sapiens	299-305
22592163-3	2012	This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10.	Alkaloids	43-52	interleukin 10	Homo sapiens	311-316
22592163-9	2012	Eight hours after LPS induction, both alkaloids significantly diminished the CCL-2 expression.	Alkaloids	38-47	C-C motif chemokine ligand 2	Homo sapiens	77-82
22406451-6	2012	The results showed that these alkaloids inhibited cell proliferation with IC(50) values between 14muM and 22muM.	Alkaloids	30-39	latexin	Homo sapiens	98-101
22353170-2	2012	C-9 arylated cinchona alkaloid catalysts have been found to be considerably superior to other bifunctional alkaloid catalysts as the promoters of this asymmetric process.	Alkaloids	22-30	complement C9	Homo sapiens	0-3
22390216-1	2012	The antineoplastic alkaloid ellipticine is a prodrug, whose pharmacological efficiency is dependent on its cytochrome P450 (P450)- and/or peroxidase-mediated activation in target tissues.	Alkaloids	19-27	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	124-148
22519642-3	2012	Compared to existing approaches to these alkaloids, our synthetic route possesses superior stereocontrol over the C-4 and C-15 stereogenic centers as well as allowing for more functional variation on the 6-membered ring.	Alkaloids	41-50	complement C4A (Rodgers blood group)	Homo sapiens	114-117
22689480-1	2012	The characterization and classification of some natural toxins (mycotoxins and alkaloids) is established by high-performance thin-layer chromatography (HPTLC) using chemically bonded stationary phases of RP-18, RP-18W, RP-8, RP-2, RP-NH(2) , RP-CN and RP-Diol.	Alkaloids	79-88	pre-mRNA processing factor 3	Homo sapiens	204-209
22689480-1	2012	The characterization and classification of some natural toxins (mycotoxins and alkaloids) is established by high-performance thin-layer chromatography (HPTLC) using chemically bonded stationary phases of RP-18, RP-18W, RP-8, RP-2, RP-NH(2) , RP-CN and RP-Diol.	Alkaloids	79-88	programmed cell death 2	Homo sapiens	219-223
22689480-1	2012	The characterization and classification of some natural toxins (mycotoxins and alkaloids) is established by high-performance thin-layer chromatography (HPTLC) using chemically bonded stationary phases of RP-18, RP-18W, RP-8, RP-2, RP-NH(2) , RP-CN and RP-Diol.	Alkaloids	79-88	RP2 activator of ARL3 GTPase	Homo sapiens	225-229
22411726-5	2012	Digoxin, as a P-glycoprotein (P-gp) substrate, was substantially effluxed in the basolateral to apical direction but inhibited by the three alkaloids.	Alkaloids	140-149	ATP binding cassette subfamily B member 1	Homo sapiens	14-28
22411726-5	2012	Digoxin, as a P-glycoprotein (P-gp) substrate, was substantially effluxed in the basolateral to apical direction but inhibited by the three alkaloids.	Alkaloids	140-149	ATP binding cassette subfamily B member 1	Homo sapiens	30-34
22411726-7	2012	These observations indicated that the three alkaloids may not only be P-gp inhibitors but also its substrates; they interact with each other and can potentially enhance their own bioavailability when taken concomitantly.	Alkaloids	44-53	ATP binding cassette subfamily B member 1	Homo sapiens	70-74
21796656-3	2012	Piperine, a major plant alkaloid/amide, has been shown to inhibit the CYP3A4 enzymatic activity in a cell-free system.	Alkaloids	24-32	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	70-76
22536197-4	2012	This review summarizes the evidence that secondary metabolites (SM) of plants, such as alkaloids, phenolics, and terpenoids can interfere with ABC transporters in cancer cells, parasites, bacteria, and fungi.	Alkaloids	87-96	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	143-146
22482398-3	2012	The effect of the alkaloids on tumor necrosis factor alpha (TNF-alpha) was measured in RAW264.7 macrophage cells.	Alkaloids	18-27	tumor necrosis factor	Mus musculus	31-58
22482398-3	2012	The effect of the alkaloids on tumor necrosis factor alpha (TNF-alpha) was measured in RAW264.7 macrophage cells.	Alkaloids	18-27	tumor necrosis factor	Mus musculus	60-69
22480315-0	2012	The interaction of telomeric DNA and C-myc22 G-quadruplex with 11 natural alkaloids.	Alkaloids	74-83	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	37-42
21564086-5	2012	By contrast, morphine and closely related alkaloids can mediate efficacious MOR-effector coupling but poorly trigger receptor regulation.	Alkaloids	42-51	opioid receptor mu 1	Homo sapiens	76-79
22101011-1	2012	We have previously reported on the differential regulation of the human delta-opioid receptor (hDOR) by alkaloid (etorphine) and peptidic (DPDPE and deltorphin I) ligands, in terms of both receptor desensitization and post-endocytic sorting.	Alkaloids	104-112	tumor protein p53 inducible nuclear protein 2	Homo sapiens	95-99