PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
10602269-1	2000	Citrate synthase is a key regulatory metabolic enzyme that catalyzes the first step in the tricarboxylic acid (TCA) cycle, the synthesis of citrate from acetyl coenzyme A and oxaloacetate.	Oxaloacetic Acid	175-187	citrate synthase	Bos taurus	0-16
10229653-1	1999	Pyruvate carboxylase (PC; EC 6.4.1.1), a member of the biotin-dependent enzyme family, catalyses the ATP-dependent carboxylation of pyruvate to oxaloacetate.	Oxaloacetic Acid	144-156	pyruvate carboxylase	Homo sapiens	0-20
10229653-1	1999	Pyruvate carboxylase (PC; EC 6.4.1.1), a member of the biotin-dependent enzyme family, catalyses the ATP-dependent carboxylation of pyruvate to oxaloacetate.	Oxaloacetic Acid	144-156	pyruvate carboxylase	Homo sapiens	22-24
9398157-0	1997	VO2+(IV) complexes with pyruvate carboxylase: activation of oxaloacetate decarboxylation and EPR properties of enzyme-VO2+ complexes.	Oxaloacetic Acid	60-72	pyruvate carboxylase	Gallus gallus	24-44
10222034-1	1999	Oxaloacetate decarboxylase (OXAD), the enzyme that catalyzes the decarboxylation of oxaloacetate to pyruvic acid and carbon dioxide, was purified 245-fold to homogeneity from Pseudomonas stutzeri.	Oxaloacetic Acid	84-96	oxaloacetate decarboxylase	Pseudomonas stutzeri	0-26
10222034-1	1999	Oxaloacetate decarboxylase (OXAD), the enzyme that catalyzes the decarboxylation of oxaloacetate to pyruvic acid and carbon dioxide, was purified 245-fold to homogeneity from Pseudomonas stutzeri.	Oxaloacetic Acid	84-96	oxaloacetate decarboxylase	Pseudomonas stutzeri	28-32
9792662-4	1998	Channeling of oxaloacetate in the malate dehydrogenase and citrate synthase-coupled systems was tested using polyethylene glycol precipitates of citrate synthase and mitochondrial malate dehydrogenase, and citrate synthase and cytosolic malate dehydrogenase.	Oxaloacetic Acid	14-26	citrate synthase	Sus scrofa	59-75
9792662-4	1998	Channeling of oxaloacetate in the malate dehydrogenase and citrate synthase-coupled systems was tested using polyethylene glycol precipitates of citrate synthase and mitochondrial malate dehydrogenase, and citrate synthase and cytosolic malate dehydrogenase.	Oxaloacetic Acid	14-26	citrate synthase	Sus scrofa	145-161
9792662-4	1998	Channeling of oxaloacetate in the malate dehydrogenase and citrate synthase-coupled systems was tested using polyethylene glycol precipitates of citrate synthase and mitochondrial malate dehydrogenase, and citrate synthase and cytosolic malate dehydrogenase.	Oxaloacetic Acid	14-26	citrate synthase	Sus scrofa	145-161
9792662-4	1998	Channeling of oxaloacetate in the malate dehydrogenase and citrate synthase-coupled systems was tested using polyethylene glycol precipitates of citrate synthase and mitochondrial malate dehydrogenase, and citrate synthase and cytosolic malate dehydrogenase.	Oxaloacetic Acid	14-26	malate dehydrogenase 1	Sus scrofa	227-257
9792662-6	1998	Aspartate aminotransferase and oxaloacetate decarboxylase were less effective competitors for oxaloacetate when precipitated citrate synthase and mitochondrial malate dehydrogenase in polyethylene glycol was used at low ionic strength compared with free enzymes in the absence of polyethylene glycol or with a co-precipitate of citrate synthase and cytosolic malate dehydrogenase.	Oxaloacetic Acid	31-43	citrate synthase	Sus scrofa	125-141
9792662-6	1998	Aspartate aminotransferase and oxaloacetate decarboxylase were less effective competitors for oxaloacetate when precipitated citrate synthase and mitochondrial malate dehydrogenase in polyethylene glycol was used at low ionic strength compared with free enzymes in the absence of polyethylene glycol or with a co-precipitate of citrate synthase and cytosolic malate dehydrogenase.	Oxaloacetic Acid	31-43	citrate synthase	Sus scrofa	328-344
9792662-6	1998	Aspartate aminotransferase and oxaloacetate decarboxylase were less effective competitors for oxaloacetate when precipitated citrate synthase and mitochondrial malate dehydrogenase in polyethylene glycol was used at low ionic strength compared with free enzymes in the absence of polyethylene glycol or with a co-precipitate of citrate synthase and cytosolic malate dehydrogenase.	Oxaloacetic Acid	31-43	malate dehydrogenase 1	Sus scrofa	349-379
9834842-1	1998	Malate dehydrogenase (MDH) (EC 1.1.1.37) catalyzes the conversion of oxaloacetate and malate.	Oxaloacetic Acid	69-81	malic enzyme 1	Homo sapiens	0-20
9834842-1	1998	Malate dehydrogenase (MDH) (EC 1.1.1.37) catalyzes the conversion of oxaloacetate and malate.	Oxaloacetic Acid	69-81	malic enzyme 1	Homo sapiens	22-25
9405351-2	1997	We have determined the crystal structure of mouse sepiapterin reductase by multiple isomorphous replacement at a resolution of 1.25 A in its ternary complex with oxaloacetate and NADP.	Oxaloacetic Acid	162-174	sepiapterin reductase	Mus musculus	50-71
9792662-7	1998	Substrate channeling of oxaloacetate with citrate synthase-mitochondrial malate dehydrogenase precipitate was inefficient at high ionic strength.	Oxaloacetic Acid	24-36	citrate synthase	Sus scrofa	42-58
9694847-7	1998	When expressed in Xenopus oocytes, SDCT1 mediated electrogenic, sodium-dependent transport of most Krebs cycle intermediates (Km = 20-60 microM), including citrate, succinate, alpha-ketoglutarate, and oxaloacetate.	Oxaloacetic Acid	201-213	solute carrier family 13 member 2L homeolog	Xenopus laevis	35-40
9650071-9	1998	Both reduced and oxidized Hsp25 from oligomeric complexes of similar size and stability against detergents and both species prevent thermal aggregation of citrate synthase and assist significantly in oxaloacetic acid-induced refolding of the enzyme.	Oxaloacetic Acid	200-216	heat shock protein 1	Mus musculus	26-31
9585002-1	1998	Pyruvate carboxylase (PC) is a biotinylated mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate.	Oxaloacetic Acid	110-122	pyruvate carboxylase	Homo sapiens	0-20
9486170-12	1998	We conclude that the labeling of aspartate in apoB-100 provides a good estimate of the isotopomer distribution in hepatic oxaloacetate but may underestimate the absolute isotopic enrichment by 50%.	Oxaloacetic Acid	122-134	apolipoprotein B	Sus scrofa	46-54
9467872-10	1997	Mitochondrial phosphoenolpyruvate carboxykinase in enterocytes in vivo could convert glycolysis-derived phosphoenolpyruvate to oxaloacetate that, with acetyl CoA, could form citrate for export to support cytosolic lipogenesis as an activator of acetyl CoA carboxylase, a source of carbon via ATP:citrate lyase and of NADPH via NADP:malate dehydrogenase or NADP:isocitrate dehydrogenase.	Oxaloacetic Acid	127-139	phosphoenolpyruvate carboxykinase [GTP], mitochondrial	Oryctolagus cuniculus	0-47
9092828-2	1997	Citrate synthase readily catalyzes solvent proton exchange of the methyl protons of dethiaacetyl-coenzyme A, a sulfur-less, ketone analog of acetyl-coenzyme A, in its ternary complex with oxaloacetate.	Oxaloacetic Acid	188-200	citrate synthase	Homo sapiens	0-16
9387145-1	1997	Citrate synthase which condenses acetyl-CoA and oxaloacetate to citrate was purified from Drosophila melanogaster.	Oxaloacetic Acid	48-60	knockdown	Drosophila melanogaster	0-16
9037708-1	1997	Citrate synthase forms citrate by deprotonation of acetyl-CoA followed by nucleophilic attack of this substrate on oxaloacetate, and subsequent hydrolysis.	Oxaloacetic Acid	115-127	citrate synthase	Homo sapiens	0-16
7730305-2	1995	Our model includes (i) isotopic exchange between alpha-ketoglutarate and glutamate, (ii) a reversible isocitrate dehydrogenase reaction, (iii) an active ATP-citrate lyase, and (iv) aspartate and malate shuttles with separate cytosolic and mitochondrial pools for oxaloacetate, malate, and fumarate.	Oxaloacetic Acid	263-275	ATP citrate lyase	Rattus norvegicus	153-170
8841108-2	1996	The diffusion of oxaloacetate from one of the active sites of malate dehydrogenase (MDH) to the active sites of citrate synthase (CS) was simulated in the presence and absence of electrostatic forces using a modeled structure for a MDH-CS fusion protein.	Oxaloacetic Acid	17-29	malic enzyme 1	Homo sapiens	62-82
8841108-2	1996	The diffusion of oxaloacetate from one of the active sites of malate dehydrogenase (MDH) to the active sites of citrate synthase (CS) was simulated in the presence and absence of electrostatic forces using a modeled structure for a MDH-CS fusion protein.	Oxaloacetic Acid	17-29	malic enzyme 1	Homo sapiens	84-87
8841108-2	1996	The diffusion of oxaloacetate from one of the active sites of malate dehydrogenase (MDH) to the active sites of citrate synthase (CS) was simulated in the presence and absence of electrostatic forces using a modeled structure for a MDH-CS fusion protein.	Oxaloacetic Acid	17-29	citrate synthase	Homo sapiens	112-128
8841108-2	1996	The diffusion of oxaloacetate from one of the active sites of malate dehydrogenase (MDH) to the active sites of citrate synthase (CS) was simulated in the presence and absence of electrostatic forces using a modeled structure for a MDH-CS fusion protein.	Oxaloacetic Acid	17-29	citrate synthase	Homo sapiens	130-132
8841108-2	1996	The diffusion of oxaloacetate from one of the active sites of malate dehydrogenase (MDH) to the active sites of citrate synthase (CS) was simulated in the presence and absence of electrostatic forces using a modeled structure for a MDH-CS fusion protein.	Oxaloacetic Acid	17-29	malic enzyme 1	Homo sapiens	232-235
8979399-1	1996	Mitochondrial citrate synthase (EC 4.1.3.7) represents the first enzyme of the tricarboxylic acid cycle, catalyzing the condensation of acetyl-CoA and oxaloacetate, finally yielding citrate and CoA.	Oxaloacetic Acid	151-163	citrate synthase, mitochondrial	Solanum tuberosum	0-30
8856084-6	1996	To study the regulatory consequences of the specific thioredoxin/NADP-MDH complexes we investigated the saturation kinetics of the substrates NADPH and oxaloacetate in presence of different concentrations of each individual thioredoxin species.	Oxaloacetic Acid	152-164	thioredoxin	Glycine max	53-64
8856084-6	1996	To study the regulatory consequences of the specific thioredoxin/NADP-MDH complexes we investigated the saturation kinetics of the substrates NADPH and oxaloacetate in presence of different concentrations of each individual thioredoxin species.	Oxaloacetic Acid	152-164	malate dehydrogenase, chloroplastic	Glycine max	70-73
7577912-0	1995	Catalytic strategy of citrate synthase: subunit interactions revealed as a consequence of a single amino acid change in the oxaloacetate binding site.	Oxaloacetic Acid	124-136	citrate synthase	Sus scrofa	22-38
7577912-1	1995	The active site of pig heart citrate synthase contains a histidine residue (H320) which interacts with the carbonyl oxygen of oxaloacetate and is implicated in substrate activation through carbonyl bond polarization, a major catalytic strategy of the enzyme.	Oxaloacetic Acid	126-138	citrate synthase	Sus scrofa	29-45
7741712-1	1995	Phosphoenolpyruvate carboxylase (PEPC) from ripened banana (Musa cavendishii L.) fruits has been purified 127-fold to apparent homogeneity and a final specific activity of 32 mumol of oxaloacetate produced/min per mg of protein.	Oxaloacetic Acid	184-196	phosphoenolpyruvate carboxylase 1	Zea mays	33-37
7722517-1	1995	Pyruvate carboxylase (EC 6.4.1.1; PC) catalyzes the formation of oxaloacetate by energy-dependent fixation of CO2 to pyruvate.	Oxaloacetic Acid	65-77	pyruvate carboxylase	Rattus norvegicus	0-20
7665595-8	1995	This histidine can also be phosphorylated by ATP, and its phosphorylation is the first step in the conversion of citrate and CoA to oxaloacetate and acetyl-CoA by ATP-citrate lyase.	Oxaloacetic Acid	132-144	ATP citrate lyase	Rattus norvegicus	163-180
7669753-0	1995	Effect of oxaloacetate and phosphorylation on ATP-citrate lyase activity.	Oxaloacetic Acid	10-22	ATP citrate lyase	Homo sapiens	46-63
7669753-1	1995	ATP-citrate lyase (CL) catalyzes the conversion of citrate and CoA to oxaloacetate (OA) and acetyl-CoA.	Oxaloacetic Acid	70-82	ATP citrate lyase	Homo sapiens	0-17
7650022-13	1995	Taken together with previous studies, the current results suggest that during glucose-induced insulin secretion there is a shuttle operating across the mitochondrial membrane in which glucose-derived pyruvate is taken up by mitochondria and carboxylated to oxaloacetate by pyruvate carboxylase.	Oxaloacetic Acid	257-269	pyruvate carboxylase	Homo sapiens	273-293
8537311-5	1995	The purified citrate synthase showed much the same optimum pH, optimum KCl concentration, effects of substrate concentrations (acetyl-CoA and oxaloacetate), and inhibitory effect by ATP as those of purified 49K protein.	Oxaloacetic Acid	142-154	citrate synthase	Homo sapiens	13-29
7849603-6	1994	Substitution of a single amino acid residue of a lactate dehydrogenase changes the enzyme specificity to that of a malate dehydrogenase, but a similar substitution in a malate dehydrogenase resulted in relaxation of the high degree of specificity for oxaloacetate.	Oxaloacetic Acid	251-263	malic enzyme 1	Homo sapiens	115-135
7849603-6	1994	Substitution of a single amino acid residue of a lactate dehydrogenase changes the enzyme specificity to that of a malate dehydrogenase, but a similar substitution in a malate dehydrogenase resulted in relaxation of the high degree of specificity for oxaloacetate.	Oxaloacetic Acid	251-263	malic enzyme 1	Homo sapiens	169-189
7511585-11	1994	In conjunction with NOS, citric acid cycle enzymes that covert fumarate to oxaloacetate (fumarase and malate dehydrogenase) and oxaloacetate to aspartate (aspartate transaminase), AS and AL form a novel arginine-citrulline cycle that enables high output NO production by cells.	Oxaloacetic Acid	75-87	fumarate hydratase	Homo sapiens	89-97
8074207-3	1994	Substrate cycling from phosphoenolpyruvate to pyruvate [via pyruvate kinase (PK)] and from oxaloacetate to pyruvate [via malic enzyme (ME)] relative to the pyruvate carboxylase (PC) flux [i.e., (PK+ME)/PC] was assessed by the ratio of the 13C enrichment of C-2 alanine relative to that in C-5 glucose.	Oxaloacetic Acid	91-103	pyruvate carboxylase	Rattus norvegicus	156-176
8010958-1	1994	The first step in the overall catalytic mechanism of citrate synthase is the binding and polarization of oxaloacetate.	Oxaloacetic Acid	105-117	citrate synthase	Sus scrofa	53-69
8010958-2	1994	Active-site residues Arg-314, Asp-312 and His-264 in Escherichia coli citrate synthase, which are involved in oxaloacetate binding, were converted by site-directed mutagenesis to Gln-314, Asn-312 and Asn-264 respectively.	Oxaloacetic Acid	110-122	citrate synthase	Sus scrofa	70-86
7511585-11	1994	In conjunction with NOS, citric acid cycle enzymes that covert fumarate to oxaloacetate (fumarase and malate dehydrogenase) and oxaloacetate to aspartate (aspartate transaminase), AS and AL form a novel arginine-citrulline cycle that enables high output NO production by cells.	Oxaloacetic Acid	75-87	malic enzyme 1	Homo sapiens	102-122
8032315-2	1994	The mitochondrial pyruvate carboxylase catalyses the ATP-dependent carboxylation of pyruvate to oxaloacetate.	Oxaloacetic Acid	96-108	pyruvate carboxylase	Rattus norvegicus	18-38
8032315-3	1994	Since pyruvate carboxylase generates oxaloacetate for Krebs cycle function, it is proposed that the enzyme activity may be enhanced by exercise.	Oxaloacetic Acid	37-49	pyruvate carboxylase	Rattus norvegicus	6-26
8212024-2	1993	Preincubation of endothelial cells with oleic- and linoleic-anilides (OAA and LAA, respectively) resulted in a time- and concentration-dependent inhibition of ionophore A23187- and thrombin-induced PGI2 synthesis.	Oxaloacetic Acid	70-73	coagulation factor II, thrombin	Homo sapiens	181-189
8215437-2	1993	These cells decarboxylated added oxaloacetate to PEP at rates exceeding 2.5 mumol min-1 mg-1 chlorophyll when ATP was added.	Oxaloacetic Acid	33-45	CD59 molecule (CD59 blood group)	Homo sapiens	82-87
8215437-3	1993	This requirement for ATP could be replaced by malate plus ADP; under these conditions this cytosol-located decarboxylation of oxaloacetate via PEP carboxykinase was sustained by respiratory ATP.	Oxaloacetic Acid	126-138	phosphoenolpyruvate carboxykinase 1	Homo sapiens	143-160
8215437-8	1993	When malate was added with oxaloacetate, ADP and Pi rates of malate decarboxylation of between 3 and 4 mumol min-1 mg-1 chlorophyll were recorded.	Oxaloacetic Acid	27-39	CD59 molecule (CD59 blood group)	Homo sapiens	109-114
8349677-9	1993	Association of citrate synthase with the malate dehydrogenase-pyruvate carboxylase binary complex does not alter activation of pyruvate carboxylase but results in citrate synthase being more reactive than free citrate synthase with oxalacetate.	Oxaloacetic Acid	232-243	citrate synthase	Homo sapiens	15-31
8349677-9	1993	Association of citrate synthase with the malate dehydrogenase-pyruvate carboxylase binary complex does not alter activation of pyruvate carboxylase but results in citrate synthase being more reactive than free citrate synthase with oxalacetate.	Oxaloacetic Acid	232-243	malic enzyme 2	Homo sapiens	41-61
8349677-9	1993	Association of citrate synthase with the malate dehydrogenase-pyruvate carboxylase binary complex does not alter activation of pyruvate carboxylase but results in citrate synthase being more reactive than free citrate synthase with oxalacetate.	Oxaloacetic Acid	232-243	pyruvate carboxylase	Homo sapiens	62-82
8266745-3	1993	Recently we have been investigating the practical application of this methodology to the estimation of kinetic parameters for the closed two enzyme system of aspartate aminotransferase (AAT) and malate dehydrogenase (MDH) (Fisher 1990a; Fisher 1990b; Bennett and Fisher, 1990): aspartate + alpha-ketoglutamate <--> glutamate + oxaloacetate; oxaloacetate + NADH <--> malate + NAD.	Oxaloacetic Acid	333-345	malic enzyme 1	Homo sapiens	195-215
8345822-1	1993	Citrate synthase catalyzes the condensation of acetyl-coenzyme A (CoA) and oxaloacetic acid to form citric acid.	Oxaloacetic Acid	75-91	citrate synthase	Homo sapiens	0-16
8266745-3	1993	Recently we have been investigating the practical application of this methodology to the estimation of kinetic parameters for the closed two enzyme system of aspartate aminotransferase (AAT) and malate dehydrogenase (MDH) (Fisher 1990a; Fisher 1990b; Bennett and Fisher, 1990): aspartate + alpha-ketoglutamate <--> glutamate + oxaloacetate; oxaloacetate + NADH <--> malate + NAD.	Oxaloacetic Acid	333-345	malic enzyme 1	Homo sapiens	217-220
8266745-3	1993	Recently we have been investigating the practical application of this methodology to the estimation of kinetic parameters for the closed two enzyme system of aspartate aminotransferase (AAT) and malate dehydrogenase (MDH) (Fisher 1990a; Fisher 1990b; Bennett and Fisher, 1990): aspartate + alpha-ketoglutamate <--> glutamate + oxaloacetate; oxaloacetate + NADH <--> malate + NAD.	Oxaloacetic Acid	347-359	malic enzyme 1	Homo sapiens	195-215
8266745-3	1993	Recently we have been investigating the practical application of this methodology to the estimation of kinetic parameters for the closed two enzyme system of aspartate aminotransferase (AAT) and malate dehydrogenase (MDH) (Fisher 1990a; Fisher 1990b; Bennett and Fisher, 1990): aspartate + alpha-ketoglutamate <--> glutamate + oxaloacetate; oxaloacetate + NADH <--> malate + NAD.	Oxaloacetic Acid	347-359	malic enzyme 1	Homo sapiens	217-220
8479597-6	1993	Oxaloacetate inhibited mMDH by partial non-competitive inhibition and cMDH by competitive inhibition.	Oxaloacetic Acid	0-12	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	23-27
8415545-3	1993	The pH optimum for oxaloacetate reduction was 6.1, with maximal activity at 7811 nmol min-1 mg protein-1, but high concentrations of oxaloacetate inhibited MDH activity.	Oxaloacetic Acid	19-31	CD59 molecule (CD59 blood group)	Homo sapiens	86-91
8415545-3	1993	The pH optimum for oxaloacetate reduction was 6.1, with maximal activity at 7811 nmol min-1 mg protein-1, but high concentrations of oxaloacetate inhibited MDH activity.	Oxaloacetic Acid	133-145	malic enzyme 1	Homo sapiens	156-159
8415545-4	1993	The Km value for oxaloacetate was determined as 22 microM for M. dessetae c-MDH and 33 microM for mammalian c-MDH.	Oxaloacetic Acid	17-29	malic enzyme 1	Homo sapiens	76-79
8415545-4	1993	The Km value for oxaloacetate was determined as 22 microM for M. dessetae c-MDH and 33 microM for mammalian c-MDH.	Oxaloacetic Acid	17-29	malic enzyme 1	Homo sapiens	110-113
16653028-1	1992	Malate dehydrogenase isoenzymes catalyzing the oxidation of malate to oxaloacetate are highly active enzymes in mitochondria, in peroxisomes, in chloroplasts, and in the cytosol.	Oxaloacetic Acid	70-82	malic enzyme 1	Homo sapiens	0-20
1324722-7	1992	The pH dependence of the dissociation constant of the ground-state analog indicates no proton uptake, while that for the transition-state analog indicates that 0.55 +/- 0.04 proton is taken up when the analog binds to the citrate synthase-oxaloacetate binary complex.	Oxaloacetic Acid	239-251	citrate synthase	Sus scrofa	222-238
1521537-2	1992	Limited proteolysis of citrate synthase from Sulfolobus solfataricus by trypsin reduced the rate of the overall reaction (acetyl-CoA + oxaloacetate + H2O----citrate + CoASH) to 4% but did not affect the hydrolysis of citryl-CoA.	Oxaloacetic Acid	135-147	CBS domain-containing protein	Saccharolobus solfataricus	23-39
1291764-4	1992	The Km values for malate (1.7 mM) and oxaloacetate (0.17 mM) and the ratio of Vmax oxidation: Vmax reduction (2.73) tend to favor the oxaloacetate reduction by mMDH.	Oxaloacetic Acid	38-50	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	160-164
1633157-10	1992	An irreversible step, however, precedes partitioning between carboxylation to give oxalacetate and release of CO2, which results in hydrolysis of PEP.	Oxaloacetic Acid	83-94	phosphoenolpyruvate carboxylase 2	Zea mays	146-149
1291764-4	1992	The Km values for malate (1.7 mM) and oxaloacetate (0.17 mM) and the ratio of Vmax oxidation: Vmax reduction (2.73) tend to favor the oxaloacetate reduction by mMDH.	Oxaloacetic Acid	134-146	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	160-164
1350279-5	1992	The aminotransferase in these hetero-enzyme complexes could be supplied with oxalacetate because binding of aminotransferase to the high molecular weight enzymes can enhance binding of malate dehydrogenase, and binding of both malate dehydrogenase and the aminotransferase facilitated binding of fumarase.	Oxaloacetic Acid	77-88	malic enzyme 1	Homo sapiens	185-205
16668905-3	1992	The maximal activity of PEPC in developing endosperms (2.67 micromoles oxaloacetate produced per minute per gram fresh weight) is approximately 20-fold and threefold greater than that of fully mature (dry seed) and germinating endosperms, respectively.	Oxaloacetic Acid	71-83	MLO-like protein 4	Zea mays	24-28
1350279-5	1992	The aminotransferase in these hetero-enzyme complexes could be supplied with oxalacetate because binding of aminotransferase to the high molecular weight enzymes can enhance binding of malate dehydrogenase, and binding of both malate dehydrogenase and the aminotransferase facilitated binding of fumarase.	Oxaloacetic Acid	77-88	malic enzyme 1	Homo sapiens	227-247
1350279-5	1992	The aminotransferase in these hetero-enzyme complexes could be supplied with oxalacetate because binding of aminotransferase to the high molecular weight enzymes can enhance binding of malate dehydrogenase, and binding of both malate dehydrogenase and the aminotransferase facilitated binding of fumarase.	Oxaloacetic Acid	77-88	fumarate hydratase	Homo sapiens	296-304
1350279-6	1992	The level of malate dehydrogenase was found to be so high (140 microM) in liver mitochondria, compared with that of citrate synthase (25 microM) and the pyruvate dehydrogenase complex (0.3 microM), that there would also be a sufficient supply of oxalacetate to citrate synthase-pyruvate dehydrogenase.	Oxaloacetic Acid	246-257	malic enzyme 1	Homo sapiens	13-33
1557428-11	1992	In the cytoplasm the aspartate is converted to fumarate utilizing urea cycle enzymes; the fumarate flows via oxaloacetate to PEP and on to glucose.	Oxaloacetic Acid	109-121	progestagen associated endometrial protein	Homo sapiens	125-128
1363914-10	1992	Because GroEL inhibits the BSA/glycerol/OAA-assisted refolding, this system will be useful in future studies on the mechanism of GroE-facilitated refolding.	Oxaloacetic Acid	40-43	GroEL	Escherichia coli	8-13
1898089-7	1991	For the mitochondrial enzyme to operate at a rate comparable to the flux through cytosolic malate dehydrogenase during ethanol metabolism (about 4 mumol min-1 per gram liver), the mitochondrial [malate] would need to be about 2 mM and the mitochondrial [oxalacetate] would need to be less than 1 microM.	Oxaloacetic Acid	254-265	malate dehydrogenase 1	Rattus norvegicus	81-111
1883366-1	1991	Alanine and lactate, as major gluconeogenic substrates, must be converted into oxaloacetate by way of pyruvate carboxylase before their entry into gluconeogenesis.	Oxaloacetic Acid	79-91	pyruvate carboxylase	Rattus norvegicus	102-122
1675605-3	1991	Experiments performed with ATP citrate lyase and S-(3,4-dicarboxy-3-hydroxybutyl)-CoA are consistent with citryl-CoA but not with citryl-enzyme being the direct precursor of the products acetyl-CoA and oxaloacetate.	Oxaloacetic Acid	202-214	ATP citrate lyase	Homo sapiens	27-44
2048720-3	1991	The ancillary coupling enzyme, aspartate aminotransferase, was used to generate a low steady-state concentration of oxalacetate.	Oxaloacetic Acid	116-127	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	31-57
1654809-4	1991	This value is similar to the dissociation constant (Kd = 4.5 +/- 1.6 microM) for the enzyme-oxalocetate complex (determined in the absence of any effector ligand), as well as to the Km for oxaloacetate (3.9 +/- 0.7 microM) in a steady-state citrate synthase catalyzed reaction at a saturating concentration of acetyl CoA.	Oxaloacetic Acid	189-201	citrate synthase	Sus scrofa	241-257
1654809-5	1991	However, the dissociation constant for the citrate synthase-oxaloacetate complex determined by the urea denaturation method is at least 25-fold lower than those determined by the other methods.	Oxaloacetic Acid	60-72	citrate synthase	Sus scrofa	43-59
1654809-7	1991	At low nondenaturing concentrations, urea inhibits the citrate synthase catalyzed reaction in an uncompetitive manner with respect to oxaloacetate, i.e., the Km for oxaloacetate decreases with an increase in urea concentration.	Oxaloacetic Acid	134-146	citrate synthase	Sus scrofa	55-71
1654809-7	1991	At low nondenaturing concentrations, urea inhibits the citrate synthase catalyzed reaction in an uncompetitive manner with respect to oxaloacetate, i.e., the Km for oxaloacetate decreases with an increase in urea concentration.	Oxaloacetic Acid	165-177	citrate synthase	Sus scrofa	55-71
1654809-8	1991	This further suggests that urea stabilizes the interaction between citrate synthase and oxaloacetate.	Oxaloacetic Acid	88-100	citrate synthase	Sus scrofa	67-83
1764503-3	1991	The first procedure is based on the conversion of oxalacetate generated from pyruvate to 14C-labelled citrate in the presence of [1-14C]acetyl-CoA and citrate synthase.	Oxaloacetic Acid	50-61	citrate synthase	Rattus norvegicus	151-167
2001241-8	1991	However, previously accumulated oxaloacetate transitorily decreased the level of the reduction of the NAD+ driven by succinate, by causing the reversal of the malate dehydrogenase reaction.	Oxaloacetic Acid	32-44	NAD-dependent malic enzyme 62 kDa isoform, mitochondrial	Solanum tuberosum	159-179
1991136-1	1991	Spermine activated citrate synthase from porcine heart by decreasing the Km value for the substrate oxaloacetate without affecting the maximal velocity.	Oxaloacetic Acid	100-112	citrate synthase	Homo sapiens	19-35
26123492-12	2015	Interestingly, transcript levels of the carriers for aspartate/glutamate AGC2, malate DIC and malate/oxaloacetate/aspartate UCP2 were increased by high glucose, a profile suggesting important mitochondrial anaplerotic/cataplerotic activities and NADPH-generating shuttles.	Oxaloacetic Acid	101-113	uncoupling protein 2	Homo sapiens	124-128
2253346-1	1990	We describe a kinetic enzymic method for serum bicarbonate analysis, using wheat germ phosphoenolpyruvate carboxylase (EC 4.1.1.31) coupled through oxaloacetate reduction with NADH in the presence of malate dehydrogenase (EC 1.1.1.37).	Oxaloacetic Acid	148-160	phosphoenolpyruvate carboxylase 2	Triticum aestivum	86-117
2173703-0	1990	The liver glucose-6-phosphatase of intact microsomes is inhibited and displays sigmoid kinetics in the presence of alpha-ketoglutarate-magnesium and oxaloacetate-magnesium chelates.	Oxaloacetic Acid	149-161	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	10-31
2173703-4	1990	In this work, we report that, when complexed with Mg2+, two endogenous dicarboxylic keto acids (alpha-ketoglutarate (alpha-KG) and oxaloacetate (OAA] inhibit the glucose-6-phosphatase activity at low concentrations of substrate.	Oxaloacetic Acid	131-143	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	162-183
33941610-10	2021	Supplements of palmitate or oxaloacetate, products of ACC1 and PC, alleviated the suppression of cell growth caused by loss of CTD-2245E15.3.	Oxaloacetic Acid	28-40	CTD	Homo sapiens	127-130
2393551-5	1990	If U-13C-glucose is used and recycling of isotope not quantitated, the resulting calculated value for Ra glucose will represent the rate of production from non-recycled carbons, plus some recycled carbons, due to potential dilution of 13C in the oxaloacetate pool and some loss of 13C in the PEPCK reaction.	Oxaloacetic Acid	246-258	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	292-297
1976013-8	1990	Pig heart citrate synthase was capable of catalyzing the condensation of glycolyl-CoA with oxaloacetate.	Oxaloacetic Acid	91-103	citrate synthase	Sus scrofa	10-26
2337600-0	1990	Proposed mechanism for the condensation reaction of citrate synthase: 1.9-A structure of the ternary complex with oxaloacetate and carboxymethyl coenzyme A.	Oxaloacetic Acid	114-126	citrate synthase	Homo sapiens	52-68
2160721-1	1990	An apparent activation of the malate dehydrogenase activity is observed in the double-reciprocal plot at high oxaloacetate concentrations when human hepatoma extracts are analyzed.	Oxaloacetic Acid	110-122	malic enzyme 1	Homo sapiens	30-50
33808495-8	2021	The pyruvate carboxylase reaction that anaplerotically supplies oxaloacetate; 5.	Oxaloacetic Acid	64-76	pyruvate carboxylase	Homo sapiens	4-24
34619358-1	2022	Malate dehydrogenase (MDH) catalyzes the conversion of NAD+ and malate to NADH and oxaloacetate in the citric acid cycle.	Oxaloacetic Acid	83-95	Malate dehydrogenase	Caenorhabditis elegans	0-20
34931827-1	2022	Cancer cell proliferation in some organs often depends on conversion of pyruvate to oxaloacetate via pyruvate carboxylase (PC) for replenishing the tricarboxylic acid cycle to support biomass production.	Oxaloacetic Acid	84-96	pyruvate carboxylase	Homo sapiens	101-121
34619358-1	2022	Malate dehydrogenase (MDH) catalyzes the conversion of NAD+ and malate to NADH and oxaloacetate in the citric acid cycle.	Oxaloacetic Acid	83-95	Malate dehydrogenase	Caenorhabditis elegans	22-25
34619358-5	2022	In steady-state enzyme kinetics assays, we measured KM values for oxaloacetate of 54 and 52 muM and KM values for NADH of 61 and 107 muM for MDH-1 and MDH-2, respectively.	Oxaloacetic Acid	66-78	Malate dehydrogenase	Caenorhabditis elegans	141-146
34619358-5	2022	In steady-state enzyme kinetics assays, we measured KM values for oxaloacetate of 54 and 52 muM and KM values for NADH of 61 and 107 muM for MDH-1 and MDH-2, respectively.	Oxaloacetic Acid	66-78	putative malate dehydrogenase, mitochondrial	Caenorhabditis elegans	151-156
34443596-1	2021	FAH domain containing protein 1 (FAHD1) acts as oxaloacetate decarboxylase in mitochondria, contributing to the regulation of the tricarboxylic acid cycle.	Oxaloacetic Acid	48-60	fumarylacetoacetate hydrolase domain containing 1	Homo sapiens	0-31
34663976-4	2021	Concurrently, AMPK phosphorylates PHGDH-Ser55, selectively increasing PHGDH oxidation of malate into oxaloacetate, thus generating NADH.	Oxaloacetic Acid	101-113	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	14-18
34663976-4	2021	Concurrently, AMPK phosphorylates PHGDH-Ser55, selectively increasing PHGDH oxidation of malate into oxaloacetate, thus generating NADH.	Oxaloacetic Acid	101-113	phosphoglycerate dehydrogenase	Homo sapiens	34-39
34663976-4	2021	Concurrently, AMPK phosphorylates PHGDH-Ser55, selectively increasing PHGDH oxidation of malate into oxaloacetate, thus generating NADH.	Oxaloacetic Acid	101-113	phosphoglycerate dehydrogenase	Homo sapiens	70-75
34289161-4	2021	In particular, d-aspartate is degraded by d-aspartate oxidase (DDO), a peroxisome-localized enzyme that catalyzes the oxidative deamination of d-aspartate to generate oxaloacetate, hydrogen peroxide, and ammonia.	Oxaloacetic Acid	167-179	D-aspartate oxidase	Homo sapiens	42-61
34289161-4	2021	In particular, d-aspartate is degraded by d-aspartate oxidase (DDO), a peroxisome-localized enzyme that catalyzes the oxidative deamination of d-aspartate to generate oxaloacetate, hydrogen peroxide, and ammonia.	Oxaloacetic Acid	167-179	D-aspartate oxidase	Homo sapiens	63-66
34443596-1	2021	FAH domain containing protein 1 (FAHD1) acts as oxaloacetate decarboxylase in mitochondria, contributing to the regulation of the tricarboxylic acid cycle.	Oxaloacetic Acid	48-60	fumarylacetoacetate hydrolase domain containing 1	Homo sapiens	33-38
34443596-3	2021	Taking the chemical features of the FAHD1 substrate oxaloacetate into account, the potential inhibitor structures are deduced.	Oxaloacetic Acid	52-64	fumarylacetoacetate hydrolase domain containing 1	Homo sapiens	36-41
34584739-3	2021	To demonstrate the capabilities of MMQX, the conversion of oxaloacetic acid to phosphoenolpyruvate by phosphoenolpyruvate carboxy-kinase (PEPCK) is observed with a time resolution of 40 ms. By lowering the entry barrier to time-resolved crystallography, MMQX should enable a broad expansion in structural studies of protein dynamics.	Oxaloacetic Acid	59-75	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	102-136
34584739-3	2021	To demonstrate the capabilities of MMQX, the conversion of oxaloacetic acid to phosphoenolpyruvate by phosphoenolpyruvate carboxy-kinase (PEPCK) is observed with a time resolution of 40 ms. By lowering the entry barrier to time-resolved crystallography, MMQX should enable a broad expansion in structural studies of protein dynamics.	Oxaloacetic Acid	59-75	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	138-143
34226744-2	2021	Here we show that oxaloacetate (OAA) is a competitive inhibitor of human lactate dehydrogenase A (LDHA) and that elevated PKM2 activity increases de novo synthesis of OAA through glutaminolysis, thereby inhibiting LDHA in cancer cells.	Oxaloacetic Acid	18-30	lactate dehydrogenase A	Homo sapiens	73-96
34226744-2	2021	Here we show that oxaloacetate (OAA) is a competitive inhibitor of human lactate dehydrogenase A (LDHA) and that elevated PKM2 activity increases de novo synthesis of OAA through glutaminolysis, thereby inhibiting LDHA in cancer cells.	Oxaloacetic Acid	18-30	lactate dehydrogenase A	Homo sapiens	98-102
34226744-2	2021	Here we show that oxaloacetate (OAA) is a competitive inhibitor of human lactate dehydrogenase A (LDHA) and that elevated PKM2 activity increases de novo synthesis of OAA through glutaminolysis, thereby inhibiting LDHA in cancer cells.	Oxaloacetic Acid	18-30	pyruvate kinase M1/2	Homo sapiens	122-126
34226744-2	2021	Here we show that oxaloacetate (OAA) is a competitive inhibitor of human lactate dehydrogenase A (LDHA) and that elevated PKM2 activity increases de novo synthesis of OAA through glutaminolysis, thereby inhibiting LDHA in cancer cells.	Oxaloacetic Acid	18-30	lactate dehydrogenase A	Homo sapiens	214-218
34226744-2	2021	Here we show that oxaloacetate (OAA) is a competitive inhibitor of human lactate dehydrogenase A (LDHA) and that elevated PKM2 activity increases de novo synthesis of OAA through glutaminolysis, thereby inhibiting LDHA in cancer cells.	Oxaloacetic Acid	32-35	lactate dehydrogenase A	Homo sapiens	73-96
34226744-2	2021	Here we show that oxaloacetate (OAA) is a competitive inhibitor of human lactate dehydrogenase A (LDHA) and that elevated PKM2 activity increases de novo synthesis of OAA through glutaminolysis, thereby inhibiting LDHA in cancer cells.	Oxaloacetic Acid	32-35	lactate dehydrogenase A	Homo sapiens	98-102
34226744-2	2021	Here we show that oxaloacetate (OAA) is a competitive inhibitor of human lactate dehydrogenase A (LDHA) and that elevated PKM2 activity increases de novo synthesis of OAA through glutaminolysis, thereby inhibiting LDHA in cancer cells.	Oxaloacetic Acid	32-35	pyruvate kinase M1/2	Homo sapiens	122-126
34226744-2	2021	Here we show that oxaloacetate (OAA) is a competitive inhibitor of human lactate dehydrogenase A (LDHA) and that elevated PKM2 activity increases de novo synthesis of OAA through glutaminolysis, thereby inhibiting LDHA in cancer cells.	Oxaloacetic Acid	32-35	lactate dehydrogenase A	Homo sapiens	214-218
34226744-2	2021	Here we show that oxaloacetate (OAA) is a competitive inhibitor of human lactate dehydrogenase A (LDHA) and that elevated PKM2 activity increases de novo synthesis of OAA through glutaminolysis, thereby inhibiting LDHA in cancer cells.	Oxaloacetic Acid	167-170	pyruvate kinase M1/2	Homo sapiens	122-126
34226744-2	2021	Here we show that oxaloacetate (OAA) is a competitive inhibitor of human lactate dehydrogenase A (LDHA) and that elevated PKM2 activity increases de novo synthesis of OAA through glutaminolysis, thereby inhibiting LDHA in cancer cells.	Oxaloacetic Acid	167-170	lactate dehydrogenase A	Homo sapiens	214-218
34226744-3	2021	We also show that replacement of human LDHA with rabbit LDHA, which is relatively resistant to OAA inhibition, eliminated the paradoxical correlation between the elevated PKM2 activity and the decreased lactate concentration in cancer cells treated with a PKM2 activator.	Oxaloacetic Acid	95-98	pyruvate kinase M1/2	Homo sapiens	171-175
34226744-5	2021	These findings describe a mechanistic explanation for the PKM2 paradox by showing that OAA accumulates and inhibits LDHA following PKM2 activation.	Oxaloacetic Acid	87-90	pyruvate kinase, muscle	Mus musculus	58-62
34226744-5	2021	These findings describe a mechanistic explanation for the PKM2 paradox by showing that OAA accumulates and inhibits LDHA following PKM2 activation.	Oxaloacetic Acid	87-90	lactate dehydrogenase A	Mus musculus	116-120
34226744-5	2021	These findings describe a mechanistic explanation for the PKM2 paradox by showing that OAA accumulates and inhibits LDHA following PKM2 activation.	Oxaloacetic Acid	87-90	pyruvate kinase, muscle	Mus musculus	131-135
34205414-2	2021	Derived from mitochondrial synthesis and/or carboxylation of alpha-ketoglutarate, it is cleaved by ATP-citrate lyase into acetyl-CoA and oxaloacetate.	Oxaloacetic Acid	137-149	ATP citrate lyase	Homo sapiens	99-116
34207926-8	2021	In addition, knockdown of Fos reduced the transcription of MDH1 and ATP5A1, genes encoding two host rate-limiting enzymes essential for the production of the TCA intermediates OAA and ATP.	Oxaloacetic Acid	176-179	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	26-29
34207926-8	2021	In addition, knockdown of Fos reduced the transcription of MDH1 and ATP5A1, genes encoding two host rate-limiting enzymes essential for the production of the TCA intermediates OAA and ATP.	Oxaloacetic Acid	176-179	malate dehydrogenase 1	Homo sapiens	59-63
34207926-9	2021	The biological significance of the transcriptional regulation of MDH1 and ATP5A1 by Fos in ILTV infection was supported by the fact that anaplerosis of OAA and ATP rescued both ICP4 transcription and virion production in infected cells under when Fos was silenced.	Oxaloacetic Acid	152-155	malate dehydrogenase 1	Homo sapiens	65-69
34207926-8	2021	In addition, knockdown of Fos reduced the transcription of MDH1 and ATP5A1, genes encoding two host rate-limiting enzymes essential for the production of the TCA intermediates OAA and ATP.	Oxaloacetic Acid	176-179	ATP synthase F1 subunit alpha	Homo sapiens	68-74
34207926-9	2021	The biological significance of the transcriptional regulation of MDH1 and ATP5A1 by Fos in ILTV infection was supported by the fact that anaplerosis of OAA and ATP rescued both ICP4 transcription and virion production in infected cells under when Fos was silenced.	Oxaloacetic Acid	152-155	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	84-87
34207926-9	2021	The biological significance of the transcriptional regulation of MDH1 and ATP5A1 by Fos in ILTV infection was supported by the fact that anaplerosis of OAA and ATP rescued both ICP4 transcription and virion production in infected cells under when Fos was silenced.	Oxaloacetic Acid	152-155	transcriptional regulator ICP4	Gallid alphaherpesvirus 1	177-181
34122722-6	2021	CIC, ACLY, and citrate are components of the citrate pathway: in LPS-activated macrophages, the mitochondrial citrate is exported by CIC into the cytosol where it is cleaved by ACLY in oxaloacetate and acetyl-CoA, precursors for ROS, NO , and PGE2 inflammatory mediators.	Oxaloacetic Acid	185-197	ATP citrate lyase	Homo sapiens	177-181
34136384-5	2021	Pyruvate carboxylase (PC) is a major anaplerotic enzyme that catalyzes the carboxylation of pyruvate to form oxaloacetate, which has been suggested to be involved in the tumorigenesis of several cancers, including PTC.	Oxaloacetic Acid	109-121	pyruvate carboxylase	Homo sapiens	0-20
35402505-6	2022	To do this, we used genome editing to knock out ATP citrate lyase (ACLY), the enzyme responsible for converting citrate to oxaloacetate and acetyl-CoA in the cytoplasm and nucleus.	Oxaloacetic Acid	123-135	ATP citrate lyase	Homo sapiens	48-65
34150393-1	2021	Pyruvate carboxylase (PC) converts pyruvate to oxaloacetate, which is an important step in gluconeogenesis.	Oxaloacetic Acid	47-59	pyruvate carboxylase	Homo sapiens	0-20
34150393-1	2021	Pyruvate carboxylase (PC) converts pyruvate to oxaloacetate, which is an important step in gluconeogenesis.	Oxaloacetic Acid	47-59	pyruvate carboxylase	Homo sapiens	22-24
35598879-8	2022	Indeed, along with the known pathway of aspartate replenishing oxaloacetate, glutamine was shown to fuel citrate synthesis through both glutaminolysis and reductive carboxylation in a GLS1-dependent manner.	Oxaloacetic Acid	63-75	glutaminase	Homo sapiens	184-188
35402505-6	2022	To do this, we used genome editing to knock out ATP citrate lyase (ACLY), the enzyme responsible for converting citrate to oxaloacetate and acetyl-CoA in the cytoplasm and nucleus.	Oxaloacetic Acid	123-135	ATP citrate lyase	Homo sapiens	67-71
35264789-5	2022	Genetic co-essentiality mapping revealed a cluster of genes that is sufficient to compose a biochemical alternative to the canonical TCA cycle, wherein mitochondrially derived citrate exported to the cytoplasm is metabolized by ATP citrate lyase, ultimately regenerating mitochondrial oxaloacetate to complete this non-canonical TCA cycle.	Oxaloacetic Acid	285-297	ATP citrate lyase	Homo sapiens	228-245
35253790-1	2022	Fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) is the first identified member of the FAH superfamily in eukaryotes, acting as oxaloacetate decarboxylase in mitochondria.	Oxaloacetic Acid	145-157	fumarylacetoacetate hydrolase domain containing 1	Mus musculus	0-57
35253790-1	2022	Fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) is the first identified member of the FAH superfamily in eukaryotes, acting as oxaloacetate decarboxylase in mitochondria.	Oxaloacetic Acid	145-157	fumarylacetoacetate hydrolase domain containing 1	Mus musculus	59-64
35253790-1	2022	Fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) is the first identified member of the FAH superfamily in eukaryotes, acting as oxaloacetate decarboxylase in mitochondria.	Oxaloacetic Acid	145-157	fumarylacetoacetate hydrolase	Mus musculus	104-107
34713507-9	2022	Acetylation of A. thaliana mMDH1 at K169, K170, and K334 decreases its oxaloacetate reduction activity, while acetylation of P. patens mMDH1 at K172 increases this activity.	Oxaloacetic Acid	71-83	malate dehydrogenase 1, NAD (soluble)	Mus musculus	27-32
35212782-2	2022	The redox state and proliferative activity of PDAC cells are maintained by the conversion of aspartic acid in the cytoplasm into oxaloacetate though aspartate aminotransferase 1 (GOT1).	Oxaloacetic Acid	129-141	glutamic-oxaloacetic transaminase 1	Homo sapiens	149-177
35212782-2	2022	The redox state and proliferative activity of PDAC cells are maintained by the conversion of aspartic acid in the cytoplasm into oxaloacetate though aspartate aminotransferase 1 (GOT1).	Oxaloacetic Acid	129-141	glutamic-oxaloacetic transaminase 1	Homo sapiens	179-183
35392250-2	2022	However, we found that for succinate-energized complex II respiration in skeletal muscle mitochondria (unencumbered by rotenone), low DeltaPsi impairs respiration by a mechanism culminating in oxaloacetate (OAA) inhibition of succinate dehydrogenase (SDH).	Oxaloacetic Acid	193-205	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	226-249
35392250-2	2022	However, we found that for succinate-energized complex II respiration in skeletal muscle mitochondria (unencumbered by rotenone), low DeltaPsi impairs respiration by a mechanism culminating in oxaloacetate (OAA) inhibition of succinate dehydrogenase (SDH).	Oxaloacetic Acid	193-205	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	251-254
35392250-2	2022	However, we found that for succinate-energized complex II respiration in skeletal muscle mitochondria (unencumbered by rotenone), low DeltaPsi impairs respiration by a mechanism culminating in oxaloacetate (OAA) inhibition of succinate dehydrogenase (SDH).	Oxaloacetic Acid	207-210	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	226-249
35392250-2	2022	However, we found that for succinate-energized complex II respiration in skeletal muscle mitochondria (unencumbered by rotenone), low DeltaPsi impairs respiration by a mechanism culminating in oxaloacetate (OAA) inhibition of succinate dehydrogenase (SDH).	Oxaloacetic Acid	207-210	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	251-254
35392250-9	2022	Metabolite studies by NMR and flux analyses by LC-MS support a mechanism, wherein DeltaPsi effects on the production of reactive oxygen alters the NADH/NAD+ ratio affecting OAA accumulation and, hence, OAA inhibition of SDH.	Oxaloacetic Acid	173-176	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	220-223
35392250-9	2022	Metabolite studies by NMR and flux analyses by LC-MS support a mechanism, wherein DeltaPsi effects on the production of reactive oxygen alters the NADH/NAD+ ratio affecting OAA accumulation and, hence, OAA inhibition of SDH.	Oxaloacetic Acid	202-205	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	220-223
3403553-1	1988	The light-activated NADP-malate dehydrogenase (NADP-MDH) catalyzes the reduction of oxaloacetate to malate in higher plant chloroplasts.	Oxaloacetic Acid	84-96	malate dehydrogenase [NADP], chloroplastic	Zea mays	20-45
2583190-1	1989	Experiments are presented which show that oxaloacetate and analogs thereof with (R)-malate substructure, on interaction with citrate synthase linked to synthase 8-anilinonaphthalene 1-sulfonate (ANS), induce identical conformational changes of a characteristic magnitude.	Oxaloacetic Acid	42-54	citrate synthase	Homo sapiens	125-141
2583190-2	1989	A conformational change of lower magnitude is also produced on binding of CoASH or ATP to citrate synthase.ANS and is completed on addition of oxaloacetate.	Oxaloacetic Acid	143-155	citrate synthase	Homo sapiens	90-106
2719924-1	1989	Citrate synthase catalyzes the slow condensation of acetyldithio-CoA [Ac(= S)CoA] with oxalacetate to form thiocitrate [Wlassics, I.D., Stille, C., & Anderson, V.E.	Oxaloacetic Acid	87-98	citrate synthase	Homo sapiens	0-16
2899080-4	1988	The conversion of glutamate to alpha-ketoglutarate could also be facilitated because in the trienzyme complex, oxalacetate might be directly transferred from malate dehydrogenase to the aminotransferase.	Oxaloacetic Acid	111-122	malic enzyme 2	Homo sapiens	158-178
3403553-1	1988	The light-activated NADP-malate dehydrogenase (NADP-MDH) catalyzes the reduction of oxaloacetate to malate in higher plant chloroplasts.	Oxaloacetic Acid	84-96	malate dehydrogenase [NADP], chloroplastic	Zea mays	47-55
3048387-1	1988	Citrate synthase is a key enzyme of the Krebs tricarboxylic acid cycle and catalyzes the stereospecific synthesis of citrate from acetyl coenzyme A and oxalacetate.	Oxaloacetic Acid	152-163	citrate synthase	Sus scrofa	0-16
3136680-2	1988	The assay uses a coupled enzyme system in which liberated CO2 is reacted with phosphoenolpyruvate and phosphoenolpyruvate carboxylase to form oxaloacetate, which in turn is reduced by malate dehydrogenase to L-malate concomitantly with the oxidation of NADH to NAD.	Oxaloacetic Acid	142-154	phosphoenolpyruvate carboxykinase 1	Homo sapiens	102-133
3415670-3	1988	Binding of 1,10-phenanthroline to pyruvate carboxylase results in complete loss of ATP/Pi exchange activity, but only a 61% decrease in pyruvate/oxaloacetate exchange activity.	Oxaloacetic Acid	145-157	pyruvate carboxylase	Gallus gallus	34-54
3182750-6	1988	The physiological function of the induction of cAspAT is considered to be to increase the supply of oxaloacetate as a substrate for cytosolic phosphoenolpyruvate carboxykinase (PEPCK) [EC 4.1.1.32] for gluconeogenesis.	Oxaloacetic Acid	100-112	glutamic-oxaloacetic transaminase 1	Rattus norvegicus	47-53
3182750-6	1988	The physiological function of the induction of cAspAT is considered to be to increase the supply of oxaloacetate as a substrate for cytosolic phosphoenolpyruvate carboxykinase (PEPCK) [EC 4.1.1.32] for gluconeogenesis.	Oxaloacetic Acid	100-112	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	177-182
3276685-12	1988	This parallel loss of binding affinities for oxaloacetate and alpha-ketoglutarate, in two mutants altered in residues at the active site of E. coli citrate synthase, strongly suggests that inhibition of this enzyme by alpha-ketoglutarate is not allosteric but occurs by competitive inhibition at the active site.	Oxaloacetic Acid	45-57	citrate synthase	Sus scrofa	148-164
3620115-6	1987	The enzymatic properties of mMDH (specific activity, Km for oxaloacetate and NADH) in the absence and in the presence of PEG 6000 are indistinguishable.	Oxaloacetic Acid	60-72	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	28-32
16665904-1	1988	The rate of phosphoenolpyruvate carboxylase activity measured through the conventional coupled assay with malate dehydrogenase is underestimated due to the instability of oxaloacetate, which undergoes partial decarboxylation into pyruvate in the presence of metal ions.	Oxaloacetic Acid	171-183	phosphoenolpyruvate carboxykinase 1	Homo sapiens	12-43
16665904-1	1988	The rate of phosphoenolpyruvate carboxylase activity measured through the conventional coupled assay with malate dehydrogenase is underestimated due to the instability of oxaloacetate, which undergoes partial decarboxylation into pyruvate in the presence of metal ions.	Oxaloacetic Acid	171-183	malic enzyme 1	Homo sapiens	106-126
3115624-3	1987	The immobilized malate dehydrogenase catalyzed the reaction between oxaloacetate and NADH to form NAD in the coupled reaction originally proposed by Karmen.	Oxaloacetic Acid	68-80	malic enzyme 1	Homo sapiens	16-36
3620523-1	1987	It has been shown by using o-phthalic acid--a concurrent inhibitor of the transport of oxalacetic acid in mitochondria that the effect of the latter on the mechanism of 2H+/Ca2+-metabolism is realized at the inner side of the inner mitochondrial membrane.	Oxaloacetic Acid	87-102	carbonic anhydrase 2	Homo sapiens	173-176
3607038-0	1987	Evidence from Fourier transform infrared spectroscopy for polarization of the carbonyl of oxaloacetate in the active site of citrate synthase.	Oxaloacetic Acid	90-102	citrate synthase	Homo sapiens	125-141
3607038-1	1987	The infrared spectrum of oxaloacetate bound in the active site of citrate synthase has been measured in the binary complex and in the ternary complex with the acetyl coenzyme A (CoA) enolate analogue carboxymethyl-CoA.	Oxaloacetic Acid	25-37	citrate synthase	Homo sapiens	66-82
3620523-2	1987	Oxalacetic acid was shown to induce not only the release of Ca2+ ions but also those of strontium and manganese accumulated in the mitochondria (100-150 nmol/mg of protein).	Oxaloacetic Acid	0-15	carbonic anhydrase 2	Homo sapiens	60-63
3814578-0	1986	Decarboxylation of oxalacetate by pyruvate carboxylase.	Oxaloacetic Acid	19-30	pyruvate carboxylase	Homo sapiens	34-54
3109450-11	1987	Malate dehydrogenase from S. acidocaldarius utilizes both NADH and NADPH to reduce oxaloacetate.	Oxaloacetic Acid	83-95	ATZ20_RS08070	Sulfolobus acidocaldarius	0-20
3814578-1	1986	The decarboxylation of oxalacetate by pyruvate carboxylase in the absence of ADP and Pi is stimulated 400-fold by the presence of oxamate, which is an inhibitory analogue of pyruvate.	Oxaloacetic Acid	23-34	pyruvate carboxylase	Homo sapiens	38-58
3814578-4	1986	The pH profiles of the full reverse reaction of pyruvate carboxylase in which oxalacetate decarboxylation is coupled to ATP formation and where Pi is the variable substrate do, however, indicate that such an acid-base catalyst is involved in the other partial reaction of the enzyme in proton transfer to and from biotin.	Oxaloacetic Acid	78-89	pyruvate carboxylase	Homo sapiens	48-68
18555296-9	1986	By using the column packed with 30 g gel having the MDH activity of 41.7 units and the FDH activity of 11.1 units, 13.8mM oxalacetate was completely converted to malate at 30 degrees C. The malate production rate was not affected by the concentration of more than 50mM formate, more than 2mM oxalacetate, and more than 0.1 mM NAD, respectively.	Oxaloacetic Acid	122-133	malic enzyme 1	Homo sapiens	52-55
3028472-0	1986	Carbon-13 and deuterium isotope effects on oxalacetate decarboxylation by pyruvate carboxylase.	Oxaloacetic Acid	43-54	pyruvate carboxylase	Homo sapiens	74-94
18555296-9	1986	By using the column packed with 30 g gel having the MDH activity of 41.7 units and the FDH activity of 11.1 units, 13.8mM oxalacetate was completely converted to malate at 30 degrees C. The malate production rate was not affected by the concentration of more than 50mM formate, more than 2mM oxalacetate, and more than 0.1 mM NAD, respectively.	Oxaloacetic Acid	122-133	aldehyde dehydrogenase 1 family member L1	Homo sapiens	87-90
3778953-1	1986	Changes in the duration of self tryptophane fluorescence of soluble cytoplasmic malate dehydrogenase (MDG) and kinetics of chemical transformation in the course of single cycles of direct and reversible reaction L-malate in equilibrium with oxalacetate were recorded.	Oxaloacetic Acid	241-252	malic enzyme 1	Homo sapiens	80-100
3778953-1	1986	Changes in the duration of self tryptophane fluorescence of soluble cytoplasmic malate dehydrogenase (MDG) and kinetics of chemical transformation in the course of single cycles of direct and reversible reaction L-malate in equilibrium with oxalacetate were recorded.	Oxaloacetic Acid	241-252	malic enzyme 1	Homo sapiens	102-105
2881415-7	1986	Additive inhibition of aspartate accumulation by fluorocitrate and (-) hydroxyacetate shows that, in addition to the tricarboxylic acid cycle, the reaction catalysed by ATP-citrate lyase serves in the synaptosomes as another source of oxaloacetate.	Oxaloacetic Acid	235-247	ATP citrate lyase	Rattus norvegicus	169-186
3778874-3	1986	Reaction of (RP)-[gamma-18O2]ITP gamma S with oxalacetate catalyzed by cytosolic PEPCK produces (SP)-thio[18O]phosphoenolpyruvate.	Oxaloacetic Acid	46-57	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	81-86
3740850-4	1986	Addition of oxaloacetate or 3-phosphoglycerate to illuminated chloroplasts results in a decrease of about 70% in the activity of NADP-malate dehydrogenase, a 30% decrease in the level of NADPH, and a 25% decrease in the reduced thioredoxin content.	Oxaloacetic Acid	12-24	LOC101027257	Zea mays	228-239
3740840-0	1986	Activity of maize leaf phosphoenolpyruvate carboxylase in relation to tautomerization and nonenzymatic decarboxylation of oxaloacetate.	Oxaloacetic Acid	122-134	MLO-like protein 4	Zea mays	23-54
3740840-1	1986	The keto form of oxaloacetate (OAA), a product of phosphoenolpyruvate carboxylase (PEPC) activity, can undergo various nonenzymatic conversions which make conventional methods of assaying the enzyme difficult, because the products may either act as inhibitors or go undetected.	Oxaloacetic Acid	17-29	MLO-like protein 4	Zea mays	50-81
3740840-1	1986	The keto form of oxaloacetate (OAA), a product of phosphoenolpyruvate carboxylase (PEPC) activity, can undergo various nonenzymatic conversions which make conventional methods of assaying the enzyme difficult, because the products may either act as inhibitors or go undetected.	Oxaloacetic Acid	17-29	MLO-like protein 4	Zea mays	83-87
3740840-1	1986	The keto form of oxaloacetate (OAA), a product of phosphoenolpyruvate carboxylase (PEPC) activity, can undergo various nonenzymatic conversions which make conventional methods of assaying the enzyme difficult, because the products may either act as inhibitors or go undetected.	Oxaloacetic Acid	31-34	MLO-like protein 4	Zea mays	50-81
3740840-1	1986	The keto form of oxaloacetate (OAA), a product of phosphoenolpyruvate carboxylase (PEPC) activity, can undergo various nonenzymatic conversions which make conventional methods of assaying the enzyme difficult, because the products may either act as inhibitors or go undetected.	Oxaloacetic Acid	31-34	MLO-like protein 4	Zea mays	83-87
3740840-4	1986	In the assay coupled to malate dehydrogenase, inaccuracies occur due to conversion of the keto form of OAA to the enol form, which is not utilized as a substrate, and due to loss of OAA by decarboxylation to pyruvate.	Oxaloacetic Acid	103-106	LOC100856934	Zea mays	24-44
3740840-4	1986	In the assay coupled to malate dehydrogenase, inaccuracies occur due to conversion of the keto form of OAA to the enol form, which is not utilized as a substrate, and due to loss of OAA by decarboxylation to pyruvate.	Oxaloacetic Acid	182-185	LOC100856934	Zea mays	24-44
3740840-7	1986	The metal enol complex of oxaloacetate (M-OAAenol) is an inhibitor of PEPC and conditions which are favorable for forming this tautomer, high pH with divalent metal ions or high concentrations of Tris buffer at a pH below its pKa value, limit catalysis.	Oxaloacetic Acid	26-38	MLO-like protein 4	Zea mays	70-74
3800895-10	1986	The low elasticity coefficient of pyruvate carboxylase towards its product oxaloacetate minimizes control by steps in the gluconeogenic pathway located after pyruvate carboxylase.	Oxaloacetic Acid	75-87	pyruvate carboxylase	Rattus norvegicus	34-54
3800895-10	1986	The low elasticity coefficient of pyruvate carboxylase towards its product oxaloacetate minimizes control by steps in the gluconeogenic pathway located after pyruvate carboxylase.	Oxaloacetic Acid	75-87	pyruvate carboxylase	Rattus norvegicus	158-178
3521681-9	1986	Muscle PEPCK activity was also increased during exercise suggesting an increased rate of conversion of oxaloacetate to pyruvate to provide net oxidation of oxaloacetate and other citric acid cycle intermediates.	Oxaloacetic Acid	103-115	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	7-12
3521681-9	1986	Muscle PEPCK activity was also increased during exercise suggesting an increased rate of conversion of oxaloacetate to pyruvate to provide net oxidation of oxaloacetate and other citric acid cycle intermediates.	Oxaloacetic Acid	156-168	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	7-12
3707142-3	1986	Under conditions of high phosphorylation potential, the limitation of malate dehydrogenase activity was caused by the accumulation of oxaloacetate in the medium.	Oxaloacetic Acid	134-146	NAD-dependent malic enzyme 62 kDa isoform, mitochondrial	Solanum tuberosum	70-90
3091918-7	1986	Oxaloacetate is primarily generated by the carboxylation of pyruvate catalysed by pyruvate carboxylase.	Oxaloacetic Acid	0-12	pyruvate carboxylase	Homo sapiens	82-102
4044608-7	1985	At low concentrations of pyruvate, stimulation of oxalacetate production and pyruvate kinase inhibition were approximately equally contributory to the overall stimulations of gluconeogenesis by angiotensin II and dexamethasone.	Oxaloacetic Acid	50-61	angiotensinogen	Rattus norvegicus	194-208
4066662-0	1985	Substrate channeling of oxalacetate in solid-state complexes of malate dehydrogenase and citrate synthase.	Oxaloacetic Acid	24-35	malic enzyme 1	Homo sapiens	64-84
4066662-0	1985	Substrate channeling of oxalacetate in solid-state complexes of malate dehydrogenase and citrate synthase.	Oxaloacetic Acid	24-35	citrate synthase	Homo sapiens	89-105
2931305-3	1985	Quinolinate inhibition of PEPCK has been reported to be competitive with oxalacetate (OAA), and therefore higher cytosolic OAA concentrations could be expected to alleviate quinolinate inhibition of PEPCK and hence reduce its effect on gluconeogenesis.	Oxaloacetic Acid	73-84	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	26-31
2931305-3	1985	Quinolinate inhibition of PEPCK has been reported to be competitive with oxalacetate (OAA), and therefore higher cytosolic OAA concentrations could be expected to alleviate quinolinate inhibition of PEPCK and hence reduce its effect on gluconeogenesis.	Oxaloacetic Acid	86-89	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	26-31
2931305-3	1985	Quinolinate inhibition of PEPCK has been reported to be competitive with oxalacetate (OAA), and therefore higher cytosolic OAA concentrations could be expected to alleviate quinolinate inhibition of PEPCK and hence reduce its effect on gluconeogenesis.	Oxaloacetic Acid	123-126	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	26-31
2931305-3	1985	Quinolinate inhibition of PEPCK has been reported to be competitive with oxalacetate (OAA), and therefore higher cytosolic OAA concentrations could be expected to alleviate quinolinate inhibition of PEPCK and hence reduce its effect on gluconeogenesis.	Oxaloacetic Acid	123-126	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	199-204
3995045-2	1985	To study the effect of facilitated diffusion of the intermediate metabolite, oxaloacetate, on the coupled reaction of aspartate aminotransferase (L-aspartate: 2-oxoglutarate aminotransferase, EC 2.6.1.1) and malate dehydrogenase (L-malate:NAD+ oxidoreductase, EC 1.1.1.37), these enzymes were co-immobilized on the surface of a collagen film.	Oxaloacetic Acid	77-89	malic enzyme 1	Homo sapiens	208-228
3995045-2	1985	To study the effect of facilitated diffusion of the intermediate metabolite, oxaloacetate, on the coupled reaction of aspartate aminotransferase (L-aspartate: 2-oxoglutarate aminotransferase, EC 2.6.1.1) and malate dehydrogenase (L-malate:NAD+ oxidoreductase, EC 1.1.1.37), these enzymes were co-immobilized on the surface of a collagen film.	Oxaloacetic Acid	77-89	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	244-258
3995045-16	1985	To interpret these rate equations, one should assume that the intermediate substrate oxaloacetate formed by aspartate aminotransferase was used by malate dehydrogenase in the diffusion layer near the film, before diffusing in the bulk solution.	Oxaloacetic Acid	85-97	malic enzyme 1	Homo sapiens	147-167
3977857-9	1985	These data implicate aspartate aminotransferase in the transfer of amino acid carbon and nitrogen from the mitochondria to the cytosol, and suggest that oxaloacetate, via phosphoenolpyruvate carboxykinase, can serve as an intermediate on the route of pyruvate formation for muscle alanine synthesis.	Oxaloacetic Acid	153-165	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	21-47
2859839-8	1985	It was suggested that, in coordination with pyruvate carboxylase, aspartate-4-decarboxylase is important in regulating the metabolic fate of oxaloacetate and thus plays a role in determining the efficiency of carbohydrate metabolism.	Oxaloacetic Acid	141-153	pyruvate carboxylase	Homo sapiens	44-64
4014670-2	1985	A simple method for preparing highly purified phosphoenolpyruvate carboxylase from maize leaves is described and the degradation of oxaloacetate under conditions of varying pH and divalent metal ion concentration is reported on.	Oxaloacetic Acid	132-144	MLO-like protein 4	Zea mays	46-77
3978085-0	1985	Evidence from 13C NMR for polarization of the carbonyl of oxaloacetate in the active site of citrate synthase.	Oxaloacetic Acid	58-70	citrate synthase	Homo sapiens	93-109
3978085-1	1985	The carbon-13 NMR spectrum of oxaloacetate bound in the active site of citrate synthase has been obtained at 90.56 MHz.	Oxaloacetic Acid	30-42	citrate synthase	Homo sapiens	71-87
3949736-4	1986	Oxaloacetate and citrate, substrates for the forward and reverse reaction catalyzed by citrate synthase, affect dimerization at concentrations of the protein which exists as monomer in their absence.	Oxaloacetic Acid	0-12	citrate synthase	Homo sapiens	87-103
20492933-7	1985	In the presence of ?-ketoglutarate, the production of (14)CO(2) from [(14)C]Asp may no longer represent AspD activity due to active transamination of Asp, presumably by aspartate aminotransferase, to oxaloacetate.	Oxaloacetic Acid	200-212	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	169-195
20492975-6	1985	The enhancement of citrate synthase activity was observed at various oxaloacetate concentrations, with an increase in V(max).	Oxaloacetic Acid	69-81	citrate synthase	Rattus norvegicus	19-35
6513986-6	1984	Malate dehydrogenase had an 8-fold greater affinity for oxaloacetate than malate, and was about 14 times more active for oxaloacetate reduction than malate oxidation.	Oxaloacetic Acid	56-68	malic enzyme 1	Homo sapiens	0-20
6513986-6	1984	Malate dehydrogenase had an 8-fold greater affinity for oxaloacetate than malate, and was about 14 times more active for oxaloacetate reduction than malate oxidation.	Oxaloacetic Acid	121-133	malic enzyme 1	Homo sapiens	0-20
6466655-6	1984	The results support our earlier suggestion that physiologically pyruvate carboxylase probably functions to generate oxaloacetate when high concentrations of condensing partner are needed during thermogenesis.	Oxaloacetic Acid	116-128	pyruvate carboxylase, mitochondrial	Mesocricetus auratus	64-84
6462326-5	1984	In rat retina the activities of OAT with glyoxalate, beta-hydroxypyruvate, pyruvate, and oxaloacetate were 51, 44, 30, and 30% of that of 2-oxoglutarate respectively.	Oxaloacetic Acid	89-101	ornithine aminotransferase	Rattus norvegicus	32-35
3978085-2	1985	In the binary complex with enzyme, the positions of the resonances of oxaloacetate are shifted relative to those of the free ligand as follows: C-1 (carboxylate), -2.5 ppm; C-2 (carbonyl), +4.3 ppm; C-3 (methylene), -0.6 ppm; C-4 (carboxylate), +1.3 ppm.	Oxaloacetic Acid	70-82	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	144-147
3978085-2	1985	In the binary complex with enzyme, the positions of the resonances of oxaloacetate are shifted relative to those of the free ligand as follows: C-1 (carboxylate), -2.5 ppm; C-2 (carbonyl), +4.3 ppm; C-3 (methylene), -0.6 ppm; C-4 (carboxylate), +1.3 ppm.	Oxaloacetic Acid	70-82	complement C2	Homo sapiens	173-176
3978085-2	1985	In the binary complex with enzyme, the positions of the resonances of oxaloacetate are shifted relative to those of the free ligand as follows: C-1 (carboxylate), -2.5 ppm; C-2 (carbonyl), +4.3 ppm; C-3 (methylene), -0.6 ppm; C-4 (carboxylate), +1.3 ppm.	Oxaloacetic Acid	70-82	complement C3	Homo sapiens	199-202
3978085-2	1985	In the binary complex with enzyme, the positions of the resonances of oxaloacetate are shifted relative to those of the free ligand as follows: C-1 (carboxylate), -2.5 ppm; C-2 (carbonyl), +4.3 ppm; C-3 (methylene), -0.6 ppm; C-4 (carboxylate), +1.3 ppm.	Oxaloacetic Acid	70-82	complement C4A (Rodgers blood group)	Homo sapiens	226-229
3978085-6	1985	Analysis of line widths in the binary complex suggests the existence of a dynamic equilibrium between two or more forms of bound oxaloacetate, primarily involving C-4.	Oxaloacetic Acid	129-141	complement C4A (Rodgers blood group)	Homo sapiens	163-166
6650821-3	1983	Acetyl-CoA is then condensed with [14C]oxaloacetate by citrate synthase to give [14C]citrate.	Oxaloacetic Acid	39-51	citrate synthase	Homo sapiens	55-71
6716477-0	1984	Crystal structure analysis and molecular model of a complex of citrate synthase with oxaloacetate and S-acetonyl-coenzyme A.	Oxaloacetic Acid	85-97	citrate synthase	Sus scrofa	63-79
6716477-1	1984	The crystal structure of the complex of pig heart citrate synthase and oxaloacetate in the presence of the potent inhibitor S-acetonyl coenzyme A has been determined at a nominal resolution of 2.9 A by Patterson search techniques and refined by restrained crystallographic refinement.	Oxaloacetic Acid	71-83	citrate synthase	Sus scrofa	50-66
6524220-1	1984	Experiments with propionyl-CoA stereoselectively deuteriated in the propionyl moiety demonstrate that the formation of (2S,3S)-methylcitric acid (1) catalysed by citrate (si)-synthase occurs with inversion of configuration in the propionyl moiety; the absolute configurations of the methylcitric acids 1 and 2 indicate a si attack on oxaloacetate.	Oxaloacetic Acid	334-346	citrate synthase	Homo sapiens	162-183
6667025-11	1983	The model indicates that at any fixed ratio of reduced to oxidized thioredoxin high proportions of active NADP-malate dehydrogenase and, hence, high rates of oxaloacetate reduction, can only occur with very high NADPH/NADP ratios.	Oxaloacetic Acid	158-170	LOC101027257	Zea mays	67-78
6359024-2	1983	The activity of MDH directed to oxaloacetate formation was shown to be 14 times and maximum velocity 13 times lower than that of the reverse reaction.	Oxaloacetic Acid	32-44	malic enzyme 2	Homo sapiens	16-19
7093213-2	1982	The hydration pathways of the fumarase-catalyzed reaction on fluorofumarate lead to a product distribution of L-threo-beta-fluoromalate to oxalacetate of 1 to 16.	Oxaloacetic Acid	139-150	fumarate hydratase	Homo sapiens	30-38
6414330-2	1983	The HCO-3 is reacted with phosphoenolpyruvate (PEP) in the presence of PEP carboxylase (EC 4.1.1.31) and the oxaloacetate formed reduced to malate by NADH in the reaction catalyzed by malate dehydrogenase (EC 1.1.1.37).	Oxaloacetic Acid	109-121	malic enzyme 2	Homo sapiens	184-204
6824331-5	1983	DPNH disrupts complexes with malate dehydrogenase and has little effect on those with the aminotransferase, while oxalacetate disrupts complexes with citrate synthase but has little effect on those with glutamate dehydrogenase.	Oxaloacetic Acid	114-125	citrate synthase	Homo sapiens	150-166
6177691-2	1982	Ca2+ release from mitochondria induced by oxalacetate or t-butyl hydroperoxide is accompanied by loss of endogenous Mg2+ and K+, swelling, loss of membrane potential, and other alterations which indicate that Ca2+ release is a result of increased inner membrane permeability.	Oxaloacetic Acid	42-53	mucin 7, secreted	Homo sapiens	116-119
6177691-6	1982	Under these conditions subsequent swelling and Mg2+ loss are inhibited.l Ultrastructural observations show the mitochondria become permeable in response to Ca2+ plus oxalacetate or Ca2+ plus t-butyl hydroperoxide in a heterogeneous manner.	Oxaloacetic Acid	166-177	mucin 7, secreted	Homo sapiens	47-50
393708-4	1979	Several alpha-keto acids (pyruvate, oxaloacetate, alpha-ketobutyrate) at 0.5-1 mM concentrations restore DNA synthesis in previously inhibited cells when combined with insulin.	Oxaloacetic Acid	36-48	insulin	Gallus gallus	168-175
7068771-4	1982	Oxalacetate production from malate (malate dehydrogenase, EC 1.1.1.37) in both the particulate and soluble fraction was strictly dependent on NAD+.	Oxaloacetic Acid	0-11	malic enzyme 2	Homo sapiens	36-56
7068771-7	1982	An increase in soluble NADP+-dependent malic enzyme activity and a decrease in NAD+-linked malate dehydrogenase indicated an increase in the ratio of pyruvate-producing to oxalacetate-producing malate oxidase activity in the cytosol of proliferating cells.	Oxaloacetic Acid	172-183	malic enzyme 2	Homo sapiens	91-111
6185934-3	1982	One possibility is that aspartate aminotransferase (AAT) could supply an extra Krebs cycle source of oxaloacetate for citrate formation.	Oxaloacetic Acid	101-113	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	24-50
6185934-3	1982	One possibility is that aspartate aminotransferase (AAT) could supply an extra Krebs cycle source of oxaloacetate for citrate formation.	Oxaloacetic Acid	101-113	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	52-55
7028733-2	1981	Aspartate is converted to oxalacetate by glutamate-oxalacetate transaminase, and the resulting oxalacetate is converted to malate by the NADH, NAD+ oxidoreductase enzyme malate dehydrogenase.	Oxaloacetic Acid	26-37	oxidoreductase	Escherichia coli	148-162
7028733-2	1981	Aspartate is converted to oxalacetate by glutamate-oxalacetate transaminase, and the resulting oxalacetate is converted to malate by the NADH, NAD+ oxidoreductase enzyme malate dehydrogenase.	Oxaloacetic Acid	51-62	oxidoreductase	Escherichia coli	148-162
7260199-5	1981	The specific malate dehydrogenase activity determined in both directions, i. e. reduction of oxaloacetate and oxidation of malate, strongly depends on the enzyme concentration.	Oxaloacetic Acid	93-105	malic enzyme 1	Homo sapiens	13-33
6788071-2	1981	The presence of a divalent metal ion together with a catalytic amount of inosine 5"-diphosphate (IDP) is essential for the formation of pyruvate from oxalacetate catalyzed by purified rat liver cytosol phosphoenolpyruvate carboxykinase (PEPCK).	Oxaloacetic Acid	150-161	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	202-235
6788071-2	1981	The presence of a divalent metal ion together with a catalytic amount of inosine 5"-diphosphate (IDP) is essential for the formation of pyruvate from oxalacetate catalyzed by purified rat liver cytosol phosphoenolpyruvate carboxykinase (PEPCK).	Oxaloacetic Acid	150-161	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	237-242
6788071-7	1981	With 10 muM added Cd2+, the apparent Km for oxalacetate was 41 muM, and the apparent Ka for IDP was 0.25 muM.	Oxaloacetic Acid	44-55	Cd2 molecule	Rattus norvegicus	18-21
6788071-9	1981	The effect of divalent transition-metal ions on PEPCK-catalyzed formation of phosphoenolpyruvate from oxalacetate was also investigated.	Oxaloacetic Acid	102-113	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	48-53
7227978-3	1981	The data suggest that the malate-aspartate shuttle is triggered by a decrease in the cytosolic oxaloacetate concentration which, due to the cytosolic aspartate aminotransferase equilibrium, leads to an increased efflux of 2-oxoglutarate and aspartate from the mitochondria in exchange for malate and glutamate, respectively.	Oxaloacetic Acid	95-107	glutamic-oxaloacetic transaminase 1	Rattus norvegicus	140-176
426765-1	1979	Citrate synthase catalyses the formation in vitro of two diastereoisomers of methylcitrate from propionyl-CoA and oxaloacetate.	Oxaloacetic Acid	114-126	citrate synthase	Homo sapiens	0-16
224920-0	1979	Interaction of a paramagnetic analogue of oxaloacetate with citrate synthase.	Oxaloacetic Acid	42-54	citrate synthase	Sus scrofa	60-76
224920-8	1979	Thus, nitrosodisulfonate may be considered as a paramagnetic analogue of oxaloacetate in its interaction with citrate synthase.	Oxaloacetic Acid	73-85	citrate synthase	Sus scrofa	110-126
36073-16	1979	Formiminoglutamate, a product of liver histidine metabolism which accumulates in conditions of excess histidine load, is a potent inhibitor of rat liver pyruvate carboxylase, with 50% inhibition being observed at a concentration of 2.8 mM, but has no detectable effect on the activity of rat liver cytosol phosphoenolpyruvate carboxykinase measured in the direction of oxaloacetate synthesis.	Oxaloacetic Acid	369-381	pyruvate carboxylase	Rattus norvegicus	153-173
435278-14	1979	It is concluded that there may be much larger changes in the free concentration of oxaloacetate than are indicated by the changes in the total content of this metabolite or that other unknown factors must play an additional role in the regulation of citrate synthase activity.	Oxaloacetic Acid	83-95	citrate synthase	Homo sapiens	250-266
680639-11	1978	Plotting the calculated free mitochondrial oxaloacetate concentration against the citrate concentration measured in the mitochondrial pellet yielded a hyperbolic saturation curve, from which an apparent Km of citrate synthase for oxaloacetate in the intact cells of 2 micron can be derived, which is comparable to the value determined with purified rat liver citrate synthase.	Oxaloacetic Acid	43-55	citrate synthase	Rattus norvegicus	209-225
680639-11	1978	Plotting the calculated free mitochondrial oxaloacetate concentration against the citrate concentration measured in the mitochondrial pellet yielded a hyperbolic saturation curve, from which an apparent Km of citrate synthase for oxaloacetate in the intact cells of 2 micron can be derived, which is comparable to the value determined with purified rat liver citrate synthase.	Oxaloacetic Acid	230-242	citrate synthase	Rattus norvegicus	209-225
566117-2	1978	Rabbit muscle pyruvate kinase has been shown to catalyze the decarboxylation of oxalacetate (Creighton, D.J.	Oxaloacetic Acid	80-91	pyruvate kinase PKLR	Oryctolagus cuniculus	14-29
656069-15	1978	It is concluded that the inhibitory effect of increased C(2) flux into the tricarboxylic acid cycle on glutamate transamination is caused by competition for oxaloacetate between the transaminase and citrate synthase.	Oxaloacetic Acid	157-169	citrate synthase	Rattus norvegicus	199-215
560867-0	1977	Substrate-inhibiton by acetyl-CoA in the condensation reaction between oxaloacetate and acetyl-CoA catalyzed by citrate synthase from pig heart.	Oxaloacetic Acid	71-83	citrate synthase	Sus scrofa	112-128
24309-4	1977	Enzyme activities are based on the formation of oxaloacetate (GOT) or pyruvate (GPT) from aspartic acid and alanine respectively with oxoglutarate.	Oxaloacetic Acid	48-60	alanine aminotransferase 1	Sus scrofa	80-83
18195-2	1977	Oxalacetate and glyoxylate are each weak inhibitors of NADP+-specific isocitrate dehydrogenase (threo-DS-isocitrate:NADP+ oxidoreductase (decarboxylating), EC 1.1.1.42)9 Together, however, they act in a concerted manner and strongly inhibit the enzyme.	Oxaloacetic Acid	0-11	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	122-136
7402332-3	1980	Here we have studied the effect of vanadate on malate dehydrogenase (MDH, EC1.1.1.37) catalysed oxidation of NADH during the formation of malate from oxalacetate in vitro.	Oxaloacetic Acid	150-161	malic enzyme 1	Homo sapiens	47-67
7402332-3	1980	Here we have studied the effect of vanadate on malate dehydrogenase (MDH, EC1.1.1.37) catalysed oxidation of NADH during the formation of malate from oxalacetate in vitro.	Oxaloacetic Acid	150-161	malic enzyme 1	Homo sapiens	69-72
560867-5	1977	The affinity of citrate synthase for oxaloacetate increase at least 20-fold on the binding of acetyl-CoA.	Oxaloacetic Acid	37-49	citrate synthase	Sus scrofa	16-32
18829-3	1977	The addition of crystalline glucose-6-phosphate dehydrogenase to the  extracts is not accompanied by formation of lactate, but reduced NADP accumulates which oxidizes due to introduction of pyruvate or oxalacetate into the medium.	Oxaloacetic Acid	202-213	glucose-6-phosphate dehydrogenase	Homo sapiens	28-61
18829-4	1977	This process is reconstructed in the system with pure enzymes (glucose-6-phosphate dehydrogenase, lactate dehydrogenase), that evidences for hydrogen transfer from reduced NADP to pyruvate, or to the oxalacetate without participation of transhydrogenase.	Oxaloacetic Acid	200-211	glucose-6-phosphate dehydrogenase	Homo sapiens	63-96
14678-3	1977	In addition to the pyruvate kinase activity of the enzyme, modification with 5"-p-fluorosulfonylbenzoyladenosine also disrupts its ability to catalyze the decarboxylation of oxaloacetate and the ATP-dependent enolization of pyruvate.	Oxaloacetic Acid	174-186	pyruvate kinase PKLR	Oryctolagus cuniculus	19-34
24425216-11	1977	Part of the OAA may be converted to malate and decarboxylated through NAD-ME, and part may be transported to the chloroplasts for decarboxylation through PEP-CK localized in the chloroplasts.	Oxaloacetic Acid	12-15	malic enzyme 2	Homo sapiens	70-76
24425216-11	1977	Part of the OAA may be converted to malate and decarboxylated through NAD-ME, and part may be transported to the chloroplasts for decarboxylation through PEP-CK localized in the chloroplasts.	Oxaloacetic Acid	12-15	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	154-160
24425216-14	1977	Studies with 3-mercaptopicolinic acid, a specific inhibitor of PEP-CK, have indicated that most (about 70%) of the OAA formed from aspartate is decarboxylated through the chloroplastic PEP-CK and the remaining (about 30%) OAA through the mitochondrial NAD-ME.	Oxaloacetic Acid	115-118	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	63-69
24425216-14	1977	Studies with 3-mercaptopicolinic acid, a specific inhibitor of PEP-CK, have indicated that most (about 70%) of the OAA formed from aspartate is decarboxylated through the chloroplastic PEP-CK and the remaining (about 30%) OAA through the mitochondrial NAD-ME.	Oxaloacetic Acid	115-118	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	185-191
24425216-14	1977	Studies with 3-mercaptopicolinic acid, a specific inhibitor of PEP-CK, have indicated that most (about 70%) of the OAA formed from aspartate is decarboxylated through the chloroplastic PEP-CK and the remaining (about 30%) OAA through the mitochondrial NAD-ME.	Oxaloacetic Acid	115-118	malic enzyme 2	Homo sapiens	252-258
24425216-14	1977	Studies with 3-mercaptopicolinic acid, a specific inhibitor of PEP-CK, have indicated that most (about 70%) of the OAA formed from aspartate is decarboxylated through the chloroplastic PEP-CK and the remaining (about 30%) OAA through the mitochondrial NAD-ME.	Oxaloacetic Acid	222-225	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	63-69
183746-7	1976	Initial-velocity patterns of the overall pyruvate dehydrogenase reaction obtained with varying TPP, CoA and NAD+ concentrations at a fixed pyruvate concentration were consistent with a sequential three-site Ping Pong mechanism; in the presence of oxaloacetate and citrate synthase to remove acetyl-CoA (an inhibitor of the overall reaction) the values of Km for NAD+ and CoA were 53+/- 5 muM and 1.9+/-0.2 muM respectively.	Oxaloacetic Acid	247-259	citrate synthase	Sus scrofa	264-280
18143-12	1977	The possible reasons for the fall in oxaloacetate concentration in acidotic livers are discussed; two of the more likely mechanisms are inhibition of the pyruvate carboxylase system and a change in the [malate]/[oxaloacetate] ratio due to the fall in intracellular pH.	Oxaloacetic Acid	37-49	pyruvate carboxylase	Rattus norvegicus	154-174
125758-3	1975	The Co2+ catalyzed condensation of oxalacetate and erythrose 4-phosphate proceeds at room temperature and neutral pH.	Oxaloacetic Acid	35-46	complement C2	Homo sapiens	4-7
1254579-3	1976	A pure preparation of citrate synthase was obtained from a crude fraction of rat heart by the specific elution  of the enzyme from the Sepharose-"ATP" with the dead end complex-forming substrates, oxalacetate and CoA.	Oxaloacetic Acid	197-208	citrate synthase	Rattus norvegicus	22-38
1248128-2	1976	Phosphoenolpyruvate carboxylase catalyzes the reaction of HCO3- with phosphoenolypyruvate to give oxalacetate.	Oxaloacetic Acid	98-109	phosphoenolpyruvate carboxykinase 1	Homo sapiens	0-31
23609-4	1976	The ratio of adenine nucleotides plays an important role in the control of citrate-synthase activity in brain, where the oxaloacetate control is not as significant as in liver.	Oxaloacetic Acid	121-133	citrate synthase	Rattus norvegicus	75-91
16659259-3	1975	The range in concentration of oxaloacetic acid needed for maximum phosphoenolpyruvate carboxykinase activity was 5 to 10 mm, and the Km for HCO(3) (-) in the exchange of (14)CO(2) into oxaloacetic acid was 26.8 mm.Changes in the activity of PEP carboxykinase and PEP carboxylase in berries were studied at weekly intervals throughout fruit development.	Oxaloacetic Acid	30-46	phosphoenolpyruvate carboxykinase 1	Homo sapiens	241-258
4447613-3	1974	The reaction pathway for the decarboxylation of oxaloacetate, catalysed by pig liver pyruvate carboxylase, was studied in the presence of saturating concentrations of K(+) and acetyl-CoA.	Oxaloacetic Acid	48-60	pyruvate carboxylase	Sus scrofa	85-105
16742816-4	1973	The brain citrate synthase from 14-day-old rats had a K(m) for oxaloacetate of 2.38mum and for acetyl-CoA of 16.9mum, and a V(max.)	Oxaloacetic Acid	63-75	citrate synthase	Rattus norvegicus	10-26
19396987-6	1974	(b) Quinolinate, an inhibitor of phosphoenolpyruvate carboxylase (GTP: oxaloacetate carboxylyase, transphosphorylating, EC 4.1.1.32), caused a several-fold increase in the oxaloacetate concentration but inhibited lactate production from pyruvate; this was accompanied by an increased reduction of mitochondrial pyridine nucleotides.	Oxaloacetic Acid	71-83	phosphoenolpyruvate carboxykinase 1	Homo sapiens	33-64
16592125-1	1973	Isolated mesophyll cells from leaves of plants that use the C(4) dicarboxylic acid pathway of CO(2) fixation have been used to demonstrate that oxaloacetic acid reduction to malic acid is coupled to the photochemical evolution of oxygen through the presumed production of NADPH.	Oxaloacetic Acid	144-160	2,4-dienoyl-CoA reductase 1	Homo sapiens	272-277
4354855-1	1973	An immobilized three-enzyme system, malate dehydrogenase (EC 1.1.1.37)-citrate synthase (EC 4.1.3.7)-lactate dehydrogenase (EC 1.1.1.27), was investigated as a model for the rate of oxalacetate production and utilization in mitochondria.	Oxaloacetic Acid	182-193	malic enzyme 1	Homo sapiens	36-56
4354855-1	1973	An immobilized three-enzyme system, malate dehydrogenase (EC 1.1.1.37)-citrate synthase (EC 4.1.3.7)-lactate dehydrogenase (EC 1.1.1.27), was investigated as a model for the rate of oxalacetate production and utilization in mitochondria.	Oxaloacetic Acid	182-193	citrate synthase	Homo sapiens	71-87
4725035-15	1973	The results suggest that the metabolism of pyruvate via pyruvate carboxylase in brain mitochondria is regulated, in part, by the intramitochondrial concentrations of pyruvate, oxaloacetate and the ATP:ADP ratio.	Oxaloacetic Acid	176-188	pyruvate carboxylase	Rattus norvegicus	56-76
5158897-11	1971	They also support the view that oxaloacetate for citrate synthesis is preferentially formed from pyruvate through pyruvate carboxylase rather than malate through malate dehydrogenase and that the mitochondrial metabolism of citrate in fat-cells is restricted.	Oxaloacetic Acid	32-44	pyruvate carboxylase	Homo sapiens	114-134
5053347-0	1972	Isomeric type of oxaloacetic acid produced from unnatural (-)-tartaric acid by fumarate hydratase.	Oxaloacetic Acid	17-33	fumarate hydratase	Homo sapiens	79-97
4354325-10	1972	In particular, pyruvate carboxylase may be present in insect flight muscle for the provision of oxaloacetate to support the large increase in activity of the tricarboxylic acid cycle which occurs when an insect takes flight.	Oxaloacetic Acid	96-108	pyruvate carboxylase	Homo sapiens	15-35
4337430-0	1972	Kinetic determination of malate dehydrogenase activity eliminating problems due to spontaneous conversion of oxaloacetate to pyruvate.	Oxaloacetic Acid	109-121	malic enzyme 1	Homo sapiens	25-45
5158897-11	1971	They also support the view that oxaloacetate for citrate synthesis is preferentially formed from pyruvate through pyruvate carboxylase rather than malate through malate dehydrogenase and that the mitochondrial metabolism of citrate in fat-cells is restricted.	Oxaloacetic Acid	32-44	malic enzyme 1	Homo sapiens	162-182
5158898-5	1971	Mitochondria prepared from fat-cells exposed to insulin put out more citrate than non-insulin-treated controls under conditions where the oxaloacetate moiety of citrate was formed from pyruvate by pyruvate carboxylase and under conditions where it was formed from malate.	Oxaloacetic Acid	138-150	insulin	Homo sapiens	48-55
5820645-4	1969	Measurements of the Michaelis constants for the substrates of citrate synthase gave values of 16mum for acetyl-CoA and 2mum for oxaloacetate.	Oxaloacetic Acid	128-140	citrate synthase	Rattus norvegicus	62-78
6049400-0	1967	Formation of oxaloacetate from unnatural (-)-tartrate by fumarate hydratase.	Oxaloacetic Acid	13-25	fumarate hydratase	Homo sapiens	57-75
5801676-3	1969	The carboxylation of pyruvate to oxaloacetate by pyruvate carboxylase in guinea-pig liver mitochondria was determined by measuring the amount of (14)C from H(14)CO(3) (-) fixed into organic acids in the presence of pyruvate, ATP, Mg(2+) and P(i).	Oxaloacetic Acid	33-45	pyruvate carboxylase, mitochondrial	Cavia porcellus	49-69
5637702-2	1968	Formation of oxalacetate from unnatural (--)-tartrate by fumarate hydratase.	Oxaloacetic Acid	13-24	fumarate hydratase	Homo sapiens	57-75
34040085-0	2021	Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord.	Oxaloacetic Acid	0-12	superoxide dismutase 1, soluble	Mus musculus	51-55
14564711-6	1967	Consequently, the pyruvate carboxylase in adipose tissue both generates mitochondrial oxaloacetate for the citrate cleavage pathway and supplies soluble NADPH for the conversion of acetyl-CoA to fatty acid.	Oxaloacetic Acid	86-98	pyruvate carboxylase	Rattus norvegicus	18-38
14340063-12	1965	The results indicate that the activation of pyruvate carboxylase by acyl-coenzyme A discovered by Utter & Keech (1963) in purified enzyme preparations also occurs in crude tissue homogenates and can play a part in the control of oxaloacetate synthesis and gluconeogenesis.	Oxaloacetic Acid	233-245	pyruvate carboxylase	Rattus norvegicus	44-64
34040085-3	2021	Therefore, we treated the ALS model superoxide dismutase 1 (SOD1) G93A mice with oxaloacetate and evaluated their neuromuscular function and lifespan.	Oxaloacetic Acid	81-93	superoxide dismutase 1, soluble	Mus musculus	36-58
34040085-3	2021	Therefore, we treated the ALS model superoxide dismutase 1 (SOD1) G93A mice with oxaloacetate and evaluated their neuromuscular function and lifespan.	Oxaloacetic Acid	81-93	superoxide dismutase 1, soluble	Mus musculus	60-64
34040085-9	2021	Similarly, the altered expression level of total NF-kappaB protein returned to that of wild-type mice with oxaloacetate treatment.	Oxaloacetic Acid	107-119	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-58
34040085-10	2021	These results suggest that the beneficial effects of oxaloacetate treatment in SOD1G93A mice may reflect the effects on neuroinflammation or bioenergetic stress.	Oxaloacetic Acid	53-65	superoxide dismutase 1, soluble	Mus musculus	79-83
33982576-5	2021	Decreased glycolysis and citric cycle activity impair BCAA transamination to branched-chain keto acids (BCKAs) due to decreased supply of amino group acceptors (alpha-ketoglutarate, pyruvate, and oxaloacetate); increased fatty acid oxidation inhibits flux of BCKA through BCKA dehydrogenase due to increased supply of NADH and acyl-CoAs.	Oxaloacetic Acid	196-208	AT-rich interaction domain 4B	Homo sapiens	54-58
33691969-2	2021	Malonyl CoA is an important intermediate in anthocyanin synthesis, and citrate, formed by citrate synthase (CS) catalysing oxaloacetate, is the precursor for the formation of malonyl-CoA.	Oxaloacetic Acid	123-135	sperm mitochondria-associated cysteine-rich protein	Mus musculus	108-110
33289792-1	2021	At the junction between the glycolysis and the tricarboxylic acid cycle-as well as various other metabolic pathways-lies the phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate node (PPO-node).	Oxaloacetic Acid	160-172	protoporphyrinogen oxidase	Homo sapiens	179-182
33931119-1	2021	Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle.	Oxaloacetic Acid	114-126	pyruvate carboxylase	Homo sapiens	0-20
33931119-1	2021	Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle.	Oxaloacetic Acid	114-126	pyruvate carboxylase	Homo sapiens	22-24
33931119-1	2021	Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle.	Oxaloacetic Acid	128-131	pyruvate carboxylase	Homo sapiens	0-20
33931119-1	2021	Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle.	Oxaloacetic Acid	128-131	pyruvate carboxylase	Homo sapiens	22-24
33463886-1	2021	Nitrilase 2 (Nit2) is a representative member of the nitrilase superfamily that catalyzes the hydrolysis of alpha-ketosuccinamate into oxaloacetate.	Oxaloacetic Acid	135-147	nitrilase family member 2	Homo sapiens	0-11
33463886-1	2021	Nitrilase 2 (Nit2) is a representative member of the nitrilase superfamily that catalyzes the hydrolysis of alpha-ketosuccinamate into oxaloacetate.	Oxaloacetic Acid	135-147	nitrilase family member 2	Homo sapiens	13-17
34056345-3	2021	Using the nicotinamide adenine dinucleotide (NADH)-oxaloacetic acid with the enzyme of malate dehydrogenase as an example, mixtures of different reagent concentrations were characterized to extract the ratio of remaining concentrations between NAD+ and NADH.	Oxaloacetic Acid	51-67	malic enzyme 2	Homo sapiens	87-107
4393782-14	1970	Pathways whereby oxaloacetate generated in the cytoplasm during fatty acid synthesis by ATP-citrate lyase may be returned to mitochondria for further citrate synthesis are discussed.	Oxaloacetic Acid	17-29	ATP citrate lyase	Rattus norvegicus	88-105
33880999-1	2021	Pyruvate carboxylase (PC) is an enzyme catalyzing the conversion of pyruvate to oxaloacetate, which possesses anaplerotic role in cellular metabolism.	Oxaloacetic Acid	80-92	pyruvate carboxylase	Homo sapiens	0-20
33880999-1	2021	Pyruvate carboxylase (PC) is an enzyme catalyzing the conversion of pyruvate to oxaloacetate, which possesses anaplerotic role in cellular metabolism.	Oxaloacetic Acid	80-92	pyruvate carboxylase	Homo sapiens	22-24
32710115-1	2021	The chloroplastic 2-oxaloacetate/malate transporter (OMT1 or DiT1) takes part in the malate valve that protects chloroplasts from excessive redox poise through export of malate and import of oxaloacetate (OAA).	Oxaloacetic Acid	20-32	anthranilic acid methyltransferase 1	Zea mays	53-57
33282912-2	2020	Within the cytosol, citrate is cleaved by ATP citrate lyase (ACLY) into oxaloacetate (OAA) and acetyl-CoA; OAA can be used for neoglucogenesis or in the TCA cycle, while acetyl-CoA is the precursor of some biosynthetic processes, including the synthesis of fatty acids.	Oxaloacetic Acid	72-84	ATP-citrate synthase	Cricetulus griseus	42-59
33274941-5	2021	d-Asp is very abundant at the embryonic stage, while it strongly decreases after birth because of the expression of d-aspartate oxidase (Ddo) enzyme, which catalyzes the oxidation of this d-amino acid into oxaloacetate, ammonium, and hydrogen peroxide.	Oxaloacetic Acid	206-218	D-aspartate oxidase	Homo sapiens	116-135
33274941-5	2021	d-Asp is very abundant at the embryonic stage, while it strongly decreases after birth because of the expression of d-aspartate oxidase (Ddo) enzyme, which catalyzes the oxidation of this d-amino acid into oxaloacetate, ammonium, and hydrogen peroxide.	Oxaloacetic Acid	206-218	D-aspartate oxidase	Homo sapiens	137-140
33334880-1	2021	Acetylation is known to regulate the activity of cytosolic phosphoenolpyruvate carboxykinase (PCK1), a key enzyme in gluconeogenesis, by promoting the reverse reaction of the enzyme (converting phosphoenolpyruvate to oxaloacetate).	Oxaloacetic Acid	217-229	phosphoenolpyruvate carboxykinase 1	Homo sapiens	94-98
32436613-1	2020	Cytosolic malate dehydrogenase (MDH) is a key enzyme that regulates the interconversion between malate and oxaloacetate (OAA).	Oxaloacetic Acid	107-119	malate dehydrogenase, cytoplasmic	Zea mays	32-35
32436613-1	2020	Cytosolic malate dehydrogenase (MDH) is a key enzyme that regulates the interconversion between malate and oxaloacetate (OAA).	Oxaloacetic Acid	121-124	malate dehydrogenase, cytoplasmic	Zea mays	32-35
32436613-5	2020	Enzymatic assays demonstrated that ZmMDH4 predominantly catalyzes the conversion from OAA to malate.	Oxaloacetic Acid	86-89	malate dehydrogenase, cytoplasmic	Zea mays	35-41
33282912-2	2020	Within the cytosol, citrate is cleaved by ATP citrate lyase (ACLY) into oxaloacetate (OAA) and acetyl-CoA; OAA can be used for neoglucogenesis or in the TCA cycle, while acetyl-CoA is the precursor of some biosynthetic processes, including the synthesis of fatty acids.	Oxaloacetic Acid	72-84	ATP-citrate synthase	Cricetulus griseus	61-65
33282912-2	2020	Within the cytosol, citrate is cleaved by ATP citrate lyase (ACLY) into oxaloacetate (OAA) and acetyl-CoA; OAA can be used for neoglucogenesis or in the TCA cycle, while acetyl-CoA is the precursor of some biosynthetic processes, including the synthesis of fatty acids.	Oxaloacetic Acid	86-89	ATP-citrate synthase	Cricetulus griseus	42-59
33282912-2	2020	Within the cytosol, citrate is cleaved by ATP citrate lyase (ACLY) into oxaloacetate (OAA) and acetyl-CoA; OAA can be used for neoglucogenesis or in the TCA cycle, while acetyl-CoA is the precursor of some biosynthetic processes, including the synthesis of fatty acids.	Oxaloacetic Acid	86-89	ATP-citrate synthase	Cricetulus griseus	61-65
32722640-5	2020	The increased levels of fumaric acid, malic acid, oxaloacetic acid and citric acid related to the citric acid cycle pathway after alpha-MSH treatment suggested enhanced energy metabolism.	Oxaloacetic Acid	50-66	STAM binding protein	Mus musculus	130-139
33282912-2	2020	Within the cytosol, citrate is cleaved by ATP citrate lyase (ACLY) into oxaloacetate (OAA) and acetyl-CoA; OAA can be used for neoglucogenesis or in the TCA cycle, while acetyl-CoA is the precursor of some biosynthetic processes, including the synthesis of fatty acids.	Oxaloacetic Acid	107-110	ATP-citrate synthase	Cricetulus griseus	42-59
33282912-2	2020	Within the cytosol, citrate is cleaved by ATP citrate lyase (ACLY) into oxaloacetate (OAA) and acetyl-CoA; OAA can be used for neoglucogenesis or in the TCA cycle, while acetyl-CoA is the precursor of some biosynthetic processes, including the synthesis of fatty acids.	Oxaloacetic Acid	107-110	ATP-citrate synthase	Cricetulus griseus	61-65
33109566-1	2020	BACKGROUND/AIM: Pyruvate carboxylase (PC) is a major anaplerotic enzyme for generating oxaloacetate for the TCA cycle and also a key enzyme in gluconeogenesis, de novo fatty acid and amino acid synthesis in normal cells.	Oxaloacetic Acid	87-99	pyruvate carboxylase	Homo sapiens	16-36
33178234-8	2020	There was evidence of 13C labeling of aspartate indicating 13CO2 fixation into oxaloacetate by PEPC and conversion to aspartate by the endogenous aspartate aminotransferase activity.	Oxaloacetic Acid	79-91	phosphoenolpyruvate carboxylase 1	Zea mays	95-99
32801864-1	2020	Purpose: Citrate synthase (CS) is a rate-limiting enzyme in the citrate cycle and is capable of catalyzing oxaloacetate and acetyl-CoA to citrate.	Oxaloacetic Acid	107-119	citrate synthase	Homo sapiens	9-25
32801864-1	2020	Purpose: Citrate synthase (CS) is a rate-limiting enzyme in the citrate cycle and is capable of catalyzing oxaloacetate and acetyl-CoA to citrate.	Oxaloacetic Acid	107-119	citrate synthase	Homo sapiens	27-29
32651957-5	2020	These allele-specific changes in transcriptional regulation lead to increased expression of gluconeogenesis-related genes (PCK1, G6PC and PPARGC1A) and their downstream metabolites (oxaloacetate and beta-D-fructose 2,6-bisphosphate).	Oxaloacetic Acid	182-194	phosphoenolpyruvate carboxykinase 1	Homo sapiens	123-127
32651957-5	2020	These allele-specific changes in transcriptional regulation lead to increased expression of gluconeogenesis-related genes (PCK1, G6PC and PPARGC1A) and their downstream metabolites (oxaloacetate and beta-D-fructose 2,6-bisphosphate).	Oxaloacetic Acid	182-194	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	129-133
32651957-5	2020	These allele-specific changes in transcriptional regulation lead to increased expression of gluconeogenesis-related genes (PCK1, G6PC and PPARGC1A) and their downstream metabolites (oxaloacetate and beta-D-fructose 2,6-bisphosphate).	Oxaloacetic Acid	182-194	PPARG coactivator 1 alpha	Homo sapiens	138-146
32619986-3	2020	The authors tested a new treatment targeting removal of CNS glutamate into the blood circulation by injection of the blood glutamate scavengers (BGSs) recombinant enzyme glutamate-oxaloacetate transaminase (rGOT1) and its cosubstrate oxaloacetic acid (OxAc).	Oxaloacetic Acid	180-192	glutamic-oxaloacetic transaminase 1	Rattus norvegicus	207-212
32619986-3	2020	The authors tested a new treatment targeting removal of CNS glutamate into the blood circulation by injection of the blood glutamate scavengers (BGSs) recombinant enzyme glutamate-oxaloacetate transaminase (rGOT1) and its cosubstrate oxaloacetic acid (OxAc).	Oxaloacetic Acid	234-250	glutamic-oxaloacetic transaminase 1	Rattus norvegicus	207-212
32619986-3	2020	The authors tested a new treatment targeting removal of CNS glutamate into the blood circulation by injection of the blood glutamate scavengers (BGSs) recombinant enzyme glutamate-oxaloacetate transaminase (rGOT1) and its cosubstrate oxaloacetic acid (OxAc).	Oxaloacetic Acid	252-256	glutamic-oxaloacetic transaminase 1	Rattus norvegicus	207-212
32671027-3	2020	Expression cassettes for three enzymes converting oxaloacetate to SA in the cytosol ("SA module") were integrated into the genome of UBR2 CBS-DHA, an optimized CEN.PK derivative.	Oxaloacetic Acid	50-62	putative ubiquitin-protein ligase UBR2	Saccharomyces cerevisiae S288C	133-137
32828504-3	2020	Pyruvate carboxylase catalyzes oxaloacetate synthesis and connects gluconeogenesis from lactate and fatty acid metabolism.	Oxaloacetic Acid	31-43	pyruvate carboxylase	Bos taurus	0-20
33013394-3	2020	Therefore, modulating TLR2 signaling can be an effective treatment strategy against MS. Oleanolic acid acetate (OAA) has antiinflammatory and immunomodulatory effects.	Oxaloacetic Acid	112-115	toll-like receptor 2	Mus musculus	22-26
32849657-9	2020	MICA expression was reduced by inhibitors of mitochondrial function, FCCP and etomoxir e.g., and depended on conversion of citrate to acetyl-CoA and oxaloacetate by ATP citrate lyase, which was also observed in several cancer cell types.	Oxaloacetic Acid	149-161	MHC class I polypeptide-related sequence A	Homo sapiens	0-4
32849657-9	2020	MICA expression was reduced by inhibitors of mitochondrial function, FCCP and etomoxir e.g., and depended on conversion of citrate to acetyl-CoA and oxaloacetate by ATP citrate lyase, which was also observed in several cancer cell types.	Oxaloacetic Acid	149-161	ATP citrate lyase	Homo sapiens	165-182
31675964-10	2019	We investigated ATP citrate lyase (ACLY) because it cleaves citrate into oxaloacetate and acetyl CoA.	Oxaloacetic Acid	73-85	ATP citrate lyase	Mus musculus	16-33
31953260-8	2020	Suppression of mitochondrial complex II by Atpenin A5 or oxaloacetic acid reverted the differentiation potential of Scd1-deficient preadipocytes to white adipocytes.	Oxaloacetic Acid	57-73	stearoyl-Coenzyme A desaturase 1	Mus musculus	116-120
31873304-6	2020	ACLY with acetyl-CoA and oxaloacetate products shows the products bound in the ASH domain, with an additional oxaloacetate in the CSH domain, which could function in ACLY autoinhibition.	Oxaloacetic Acid	25-37	ATP citrate lyase	Homo sapiens	0-4
31873304-6	2020	ACLY with acetyl-CoA and oxaloacetate products shows the products bound in the ASH domain, with an additional oxaloacetate in the CSH domain, which could function in ACLY autoinhibition.	Oxaloacetic Acid	25-37	ATP citrate lyase	Homo sapiens	166-170
31873304-6	2020	ACLY with acetyl-CoA and oxaloacetate products shows the products bound in the ASH domain, with an additional oxaloacetate in the CSH domain, which could function in ACLY autoinhibition.	Oxaloacetic Acid	110-122	ATP citrate lyase	Homo sapiens	0-4
31873304-6	2020	ACLY with acetyl-CoA and oxaloacetate products shows the products bound in the ASH domain, with an additional oxaloacetate in the CSH domain, which could function in ACLY autoinhibition.	Oxaloacetic Acid	110-122	ATP citrate lyase	Homo sapiens	166-170
32051209-2	2020	PPC combines phosphoenolpyruvate with CO2 (as HCO3 -), forming oxaloacetate.	Oxaloacetic Acid	63-75	phosphoenolpyruvate carboxykinase 1	Homo sapiens	0-3
32110376-4	2020	The blood glutamate scavengers, oxaloacetate and pyruvate, degrade glutamate in the blood to its inactive metabolite, 2-ketoglutarate, by the coenzymes glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT), respectively.	Oxaloacetic Acid	32-44	glutamic--pyruvic transaminase	Homo sapiens	198-229
32110376-4	2020	The blood glutamate scavengers, oxaloacetate and pyruvate, degrade glutamate in the blood to its inactive metabolite, 2-ketoglutarate, by the coenzymes glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT), respectively.	Oxaloacetic Acid	32-44	glutamic--pyruvic transaminase	Homo sapiens	231-234
31538237-1	2019	The reversible oxidation of L-malate to oxaloacetate is catalyzed by NAD(H)-dependent malate dehydrogenase (MDH).	Oxaloacetic Acid	40-52	malate dehydrogenase 1	Homo sapiens	108-111
31697914-1	2019	Pyruvate carboxylase (PC) is a biotin-containing enzyme that converts pyruvate to oxaloacetate.	Oxaloacetic Acid	82-94	pyruvate carboxylase	Homo sapiens	0-20
31697914-1	2019	Pyruvate carboxylase (PC) is a biotin-containing enzyme that converts pyruvate to oxaloacetate.	Oxaloacetic Acid	82-94	pyruvate carboxylase	Homo sapiens	22-24
31696211-3	2019	In this study, we investigated the significance of the associated oxaloacetate decarboxylase activity which is also catalysed by HOGA1.	Oxaloacetic Acid	66-78	4-hydroxy-2-oxoglutarate aldolase 1	Homo sapiens	129-134
31675964-10	2019	We investigated ATP citrate lyase (ACLY) because it cleaves citrate into oxaloacetate and acetyl CoA.	Oxaloacetic Acid	73-85	ATP citrate lyase	Mus musculus	35-39
31180060-1	2019	Pyruvate carboxylase (Pyc) catalyzes formation of oxaloacetic acid from pyruvic acid by fixing one mole of CO2.	Oxaloacetic Acid	50-66	pyruvate carboxylase	Homo sapiens	0-20
31411782-1	2019	ATP-citrate lyase (ACLY) catalyzes production of acetyl-CoA and oxaloacetate from CoA and citrate using ATP.	Oxaloacetic Acid	64-76	ATP citrate lyase	Homo sapiens	19-23
30982986-10	2019	In addition, OAA-treated specimens showed the altered localization patterns of inflammatory and bone formation-related signaling molecules including CD31, F4/80, IL-6, and osteocalcin.	Oxaloacetic Acid	13-16	platelet/endothelial cell adhesion molecule 1	Mus musculus	149-153
30982986-10	2019	In addition, OAA-treated specimens showed the altered localization patterns of inflammatory and bone formation-related signaling molecules including CD31, F4/80, IL-6, and osteocalcin.	Oxaloacetic Acid	13-16	adhesion G protein-coupled receptor E1	Mus musculus	155-160
30982986-10	2019	In addition, OAA-treated specimens showed the altered localization patterns of inflammatory and bone formation-related signaling molecules including CD31, F4/80, IL-6, and osteocalcin.	Oxaloacetic Acid	13-16	interleukin 6	Mus musculus	162-166
30982986-10	2019	In addition, OAA-treated specimens showed the altered localization patterns of inflammatory and bone formation-related signaling molecules including CD31, F4/80, IL-6, and osteocalcin.	Oxaloacetic Acid	13-16	bone gamma-carboxyglutamate protein 2	Mus musculus	172-183
31422819-7	2019	GOT2 encodes the mitochondrial glutamate oxaloacetate transaminase.	Oxaloacetic Acid	41-53	glutamatic-oxaloacetic transaminase 2, mitochondrial	Mus musculus	0-4
31180060-1	2019	Pyruvate carboxylase (Pyc) catalyzes formation of oxaloacetic acid from pyruvic acid by fixing one mole of CO2.	Oxaloacetic Acid	50-66	pyruvate carboxylase	Homo sapiens	22-25
30663275-8	2019	Administration of OAA significantly reduced the extent of liver injury in the LPVL model with lower levels of alanine aminotransferase (ALT; P < 0.01), aspartate aminotransferase (AST; P < 0.01), and reduced liver necrosis (P < 0.05).	Oxaloacetic Acid	18-21	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	155-181
31019471-1	2019	The Citrate Lyase (ACL) is the main cytosolic enzyme that converts the citrate exported from mitochondria by the SLC25A1 carrier in Acetyl Coenzyme A (acetyl-CoA) and oxaloacetate.	Oxaloacetic Acid	167-179	solute carrier family 25 member 1	Homo sapiens	113-120
30663275-8	2019	Administration of OAA significantly reduced the extent of liver injury in the LPVL model with lower levels of alanine aminotransferase (ALT; P < 0.01), aspartate aminotransferase (AST; P < 0.01), and reduced liver necrosis (P < 0.05).	Oxaloacetic Acid	18-21	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	183-186
30944472-1	2019	ATP-citrate lyase (ACLY) is a central metabolic enzyme and catalyses the ATP-dependent conversion of citrate and coenzyme A (CoA) to oxaloacetate and acetyl-CoA1-5.	Oxaloacetic Acid	133-145	ATP citrate lyase	Homo sapiens	0-17
30944472-1	2019	ATP-citrate lyase (ACLY) is a central metabolic enzyme and catalyses the ATP-dependent conversion of citrate and coenzyme A (CoA) to oxaloacetate and acetyl-CoA1-5.	Oxaloacetic Acid	133-145	ATP citrate lyase	Homo sapiens	19-23
30944476-1	2019	Across different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL) catalyses the ATP-dependent and coenzyme A (CoA)-dependent conversion of citrate, a metabolic product of the Krebs cycle, to oxaloacetate and the high-energy biosynthetic precursor acetyl-CoA1.	Oxaloacetic Acid	204-216	ATP citrate lyase	Homo sapiens	35-52
30944476-1	2019	Across different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL) catalyses the ATP-dependent and coenzyme A (CoA)-dependent conversion of citrate, a metabolic product of the Krebs cycle, to oxaloacetate and the high-energy biosynthetic precursor acetyl-CoA1.	Oxaloacetic Acid	204-216	ATP citrate lyase	Homo sapiens	54-58
30944476-1	2019	Across different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL) catalyses the ATP-dependent and coenzyme A (CoA)-dependent conversion of citrate, a metabolic product of the Krebs cycle, to oxaloacetate and the high-energy biosynthetic precursor acetyl-CoA1.	Oxaloacetic Acid	204-216	cytochrome c oxidase assembly factor 1	Homo sapiens	267-271
30385511-4	2018	We confirmed decades-old reports that oxaloacetate (OAA) inhibits succinate dehydrogenase (SDH).	Oxaloacetic Acid	38-50	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	66-89
30794680-2	2019	Citrate synthase from M. sedula (MsCS) is an enzyme involved in the first step of the incomplete TCA/glyoxylate cycle by converting oxaloacetate and acetyl-CoA into citrate and coenzyme A.	Oxaloacetic Acid	132-144	citrate synthase	Metallosphaera sedula	0-16
30611567-2	2019	The citrate synthase from M. sedula (MsCS) is an enzyme involved in the first step of the incomplete TCA cycle, catalyzing the conversion of oxaloacetate and acetyl-CoA into citrate and coenzyme A.	Oxaloacetic Acid	141-153	citrate synthase	Metallosphaera sedula	4-20
30638660-2	2019	The 3-HP/4-HB cycle in M. sedula is associated with central metabolism, and malate dehydrogenase (MDH) is an enzyme involved in the central metabolism that converts malate to oxaloacetate.	Oxaloacetic Acid	175-187	NADP-dependent malic enzyme	Metallosphaera sedula	76-96
30638660-2	2019	The 3-HP/4-HB cycle in M. sedula is associated with central metabolism, and malate dehydrogenase (MDH) is an enzyme involved in the central metabolism that converts malate to oxaloacetate.	Oxaloacetic Acid	175-187	NADP-dependent malic enzyme	Metallosphaera sedula	98-101
30045381-1	2018	Pyruvate carboxylase (PC) is a biotin-containing enzyme that is responsible for the adenosine triphosphate-dependent carboxylation of pyruvate to oxaloacetate, a key intermediate in the tricarboxylic acid cycle.	Oxaloacetic Acid	146-158	pyruvate carboxylase	Homo sapiens	0-20
30045381-1	2018	Pyruvate carboxylase (PC) is a biotin-containing enzyme that is responsible for the adenosine triphosphate-dependent carboxylation of pyruvate to oxaloacetate, a key intermediate in the tricarboxylic acid cycle.	Oxaloacetic Acid	146-158	pyruvate carboxylase	Homo sapiens	22-24
30385511-4	2018	We confirmed decades-old reports that oxaloacetate (OAA) inhibits succinate dehydrogenase (SDH).	Oxaloacetic Acid	38-50	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	91-94
30385511-4	2018	We confirmed decades-old reports that oxaloacetate (OAA) inhibits succinate dehydrogenase (SDH).	Oxaloacetic Acid	52-55	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	66-89
30385511-4	2018	We confirmed decades-old reports that oxaloacetate (OAA) inhibits succinate dehydrogenase (SDH).	Oxaloacetic Acid	52-55	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	91-94
30385511-11	2018	In summary, our findings, taken together, support a mechanism (detailed within) wherein succinate-energized respiration as a function of increasing [ADP] is initially increased by [ADP]-dependent effects on membrane potential but subsequently decreased at higher [ADP] by inhibition of succinate dehydrogenase by OAA.	Oxaloacetic Acid	313-316	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	286-309
30193097-3	2018	Under high glucose, p300-dependent hyperacetylation of PCK1 did not lead to protein degradation but instead increased the ability of PCK1 to perform the anaplerotic reaction, converting phosphoenolpyruvate to oxaloacetate.	Oxaloacetic Acid	209-221	E1A binding protein p300	Homo sapiens	20-24
30356028-1	2018	Malate dehydrogenase plays crucial roles in energy homeostasis, plant development and cold and salt tolerance, as it mediates the reversible conversion of malate to oxaloacetate.	Oxaloacetic Acid	165-177	malate dehydrogenase	Malus domestica	0-20
30193097-3	2018	Under high glucose, p300-dependent hyperacetylation of PCK1 did not lead to protein degradation but instead increased the ability of PCK1 to perform the anaplerotic reaction, converting phosphoenolpyruvate to oxaloacetate.	Oxaloacetic Acid	209-221	phosphoenolpyruvate carboxykinase 1	Homo sapiens	55-59
30193097-3	2018	Under high glucose, p300-dependent hyperacetylation of PCK1 did not lead to protein degradation but instead increased the ability of PCK1 to perform the anaplerotic reaction, converting phosphoenolpyruvate to oxaloacetate.	Oxaloacetic Acid	209-221	phosphoenolpyruvate carboxykinase 1	Homo sapiens	133-137
29751795-9	2018	RESULTS: Inhibition of GOT1 sensitized the cancer cells to glucose deprivation, which was partially counteracted by oxaloacetate and phosphoenol pyruvate, metabolic intermediates downstream of GOT1.	Oxaloacetic Acid	116-128	glutamic-oxaloacetic transaminase 1	Homo sapiens	23-27
30195238-1	2018	ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous hydrolysis of ATP to ADP and phosphate.	Oxaloacetic Acid	142-154	ATP citrate lyase	Homo sapiens	0-17
30195238-1	2018	ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous hydrolysis of ATP to ADP and phosphate.	Oxaloacetic Acid	142-154	ATP citrate lyase	Homo sapiens	19-23
29351723-8	2018	Moreover, UCP2-mediated aspartate, oxaloacetate, and malate antiport with phosphate is expected to alter metabolism of cancer cells.	Oxaloacetic Acid	35-47	uncoupling protein 2	Homo sapiens	10-14
30005601-4	2018	Pyruvate carboxylase (PC) is key enzyme that converts pyruvate into oxaloacetate for utilization in gluconeogenesis and replenishment of the TCA cycle.	Oxaloacetic Acid	68-80	pyruvate carboxylase	Homo sapiens	0-20
30005601-4	2018	Pyruvate carboxylase (PC) is key enzyme that converts pyruvate into oxaloacetate for utilization in gluconeogenesis and replenishment of the TCA cycle.	Oxaloacetic Acid	68-80	pyruvate carboxylase	Homo sapiens	22-24
30050389-3	2018	Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier-SLC25A1-encoded protein-it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY).	Oxaloacetic Acid	200-212	solute carrier family 25 member 1	Homo sapiens	142-149
29655770-1	2018	Pyruvate carboxylase (PC) catalyzes the conversion of pyruvate to oxaloacetate (OAA), an important metabolic reaction in a wide range of organisms.	Oxaloacetic Acid	66-78	AT695_RS12140	Staphylococcus aureus	0-20
29655770-1	2018	Pyruvate carboxylase (PC) catalyzes the conversion of pyruvate to oxaloacetate (OAA), an important metabolic reaction in a wide range of organisms.	Oxaloacetic Acid	66-78	AT695_RS12140	Staphylococcus aureus	22-24
29655770-1	2018	Pyruvate carboxylase (PC) catalyzes the conversion of pyruvate to oxaloacetate (OAA), an important metabolic reaction in a wide range of organisms.	Oxaloacetic Acid	80-83	AT695_RS12140	Staphylococcus aureus	0-20
29655770-1	2018	Pyruvate carboxylase (PC) catalyzes the conversion of pyruvate to oxaloacetate (OAA), an important metabolic reaction in a wide range of organisms.	Oxaloacetic Acid	80-83	AT695_RS12140	Staphylococcus aureus	22-24
29655770-4	2018	To assist in efforts to find, develop, and characterize small molecule effectors of PC, a novel fixed-time assay has been developed based on the reaction of OAA with the diazonium salt, Fast Violet B (FVB), which produces a colored adduct with an absorbance maximum at 530 nm.	Oxaloacetic Acid	157-160	AT695_RS12140	Staphylococcus aureus	84-86
29548885-7	2018	Interestingly, prior injection of SB 242084 (a selective 5-HT2C antagonist) into the amygdala also blocked the MK-212 effects on OAA.	Oxaloacetic Acid	129-132	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	57-63
29505886-4	2018	Moreover, OAA treatment significantly decreased the elevations of IL-1beta, IL-6, TNF-alpha, TGF-beta1, and fibronectin, and the activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in the lungs of PHMG-P-treated mice.	Oxaloacetic Acid	10-13	interleukin 1 beta	Mus musculus	66-74
29505886-4	2018	Moreover, OAA treatment significantly decreased the elevations of IL-1beta, IL-6, TNF-alpha, TGF-beta1, and fibronectin, and the activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in the lungs of PHMG-P-treated mice.	Oxaloacetic Acid	10-13	interleukin 6	Mus musculus	76-80
29505886-4	2018	Moreover, OAA treatment significantly decreased the elevations of IL-1beta, IL-6, TNF-alpha, TGF-beta1, and fibronectin, and the activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in the lungs of PHMG-P-treated mice.	Oxaloacetic Acid	10-13	tumor necrosis factor	Mus musculus	82-91
29505886-4	2018	Moreover, OAA treatment significantly decreased the elevations of IL-1beta, IL-6, TNF-alpha, TGF-beta1, and fibronectin, and the activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in the lungs of PHMG-P-treated mice.	Oxaloacetic Acid	10-13	transforming growth factor, beta 1	Mus musculus	93-102
29505886-4	2018	Moreover, OAA treatment significantly decreased the elevations of IL-1beta, IL-6, TNF-alpha, TGF-beta1, and fibronectin, and the activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in the lungs of PHMG-P-treated mice.	Oxaloacetic Acid	10-13	fibronectin 1	Mus musculus	108-119
29505886-4	2018	Moreover, OAA treatment significantly decreased the elevations of IL-1beta, IL-6, TNF-alpha, TGF-beta1, and fibronectin, and the activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in the lungs of PHMG-P-treated mice.	Oxaloacetic Acid	10-13	interferon activated gene 208	Mus musculus	173-198
29505886-4	2018	Moreover, OAA treatment significantly decreased the elevations of IL-1beta, IL-6, TNF-alpha, TGF-beta1, and fibronectin, and the activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in the lungs of PHMG-P-treated mice.	Oxaloacetic Acid	10-13	NLR family, pyrin domain containing 3	Mus musculus	200-205
29857490-3	2018	In our study, we found that oxaloacetate (OA) effectively alleviated liver injury which was induced by hydrogen peroxide (H2O2) in vitro and carbon tetrachloride (CCl4) in vivo.	Oxaloacetic Acid	28-40	C-C motif chemokine ligand 4	Homo sapiens	163-167
29751795-9	2018	RESULTS: Inhibition of GOT1 sensitized the cancer cells to glucose deprivation, which was partially counteracted by oxaloacetate and phosphoenol pyruvate, metabolic intermediates downstream of GOT1.	Oxaloacetic Acid	116-128	glutamic-oxaloacetic transaminase 1	Homo sapiens	193-197
29751795-14	2018	GOT1 is crucial to provide oxaloacetate at low glucose levels, likely to maintain the redox homeostasis.	Oxaloacetic Acid	27-39	glutamic-oxaloacetic transaminase 1	Homo sapiens	0-4
28942523-1	2018	The plastidic C4 Zea mays NADP-malate dehydrogenase (ZmNADP-MDH), responsible for catalysis of oxaloacetate to malate, was overexpressed in Arabidopsis thaliana to assess its impact on photosynthesis and tolerance to salinity stress.	Oxaloacetic Acid	95-107	malate dehydrogenase [NADP], chloroplastic	Zea mays	53-63
29643369-1	2018	Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate.	Oxaloacetic Acid	83-95	pyruvate carboxylase	Homo sapiens	0-20
29643369-1	2018	Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate.	Oxaloacetic Acid	83-95	pyruvate carboxylase	Homo sapiens	22-24
29262588-4	2017	Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M), which is encoded by PCK2, catalyzes the conversion of oxaloacetate to phosphoenolpyruvate.	Oxaloacetic Acid	113-125	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	49-56
29208641-6	2018	AOX1C is insensitive to all seven organic acids, AOX1A and AOX1D are both activated by 2-oxoglutarate, but only AOX1A is additionally activated by oxaloacetate.	Oxaloacetic Acid	147-159	alternative oxidase 1C	Arabidopsis thaliana	0-5
29208641-6	2018	AOX1C is insensitive to all seven organic acids, AOX1A and AOX1D are both activated by 2-oxoglutarate, but only AOX1A is additionally activated by oxaloacetate.	Oxaloacetic Acid	147-159	alternative oxidase 1A	Arabidopsis thaliana	112-117
29094409-2	2018	Oxaloacetate (OAA) molecules are the intermediate substrates that are transferred from the MDH to CS to carry out sequential catalysis.	Oxaloacetic Acid	0-12	citrate synthase	Bos taurus	98-100
29094409-2	2018	Oxaloacetate (OAA) molecules are the intermediate substrates that are transferred from the MDH to CS to carry out sequential catalysis.	Oxaloacetic Acid	14-17	citrate synthase	Bos taurus	98-100
30392850-1	2018	Pepck is a metabolic enzyme that participates in gluconeogenesis through the conversion of oxaloacetate into phosphoenol pyruvate.	Oxaloacetic Acid	91-103	Phosphoenolpyruvate carboxykinase 1	Drosophila melanogaster	0-5
28887308-5	2017	Interestingly, the METTL12-mediated methylation inhibited CS activity and was blocked by the CS substrate oxaloacetate.	Oxaloacetic Acid	106-118	citrate synthase lysine methyltransferase	Homo sapiens	19-26
28887308-5	2017	Interestingly, the METTL12-mediated methylation inhibited CS activity and was blocked by the CS substrate oxaloacetate.	Oxaloacetic Acid	106-118	citrate synthase	Homo sapiens	58-60
28887308-5	2017	Interestingly, the METTL12-mediated methylation inhibited CS activity and was blocked by the CS substrate oxaloacetate.	Oxaloacetic Acid	106-118	citrate synthase	Homo sapiens	93-95
29262588-4	2017	Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M), which is encoded by PCK2, catalyzes the conversion of oxaloacetate to phosphoenolpyruvate.	Oxaloacetic Acid	113-125	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	79-83
28538181-3	2017	To investigate the mechanism mediating the effect of fumarase-related metabolites on hypertension, we considered the pathway in which L-malate can be converted to oxaloacetate, aspartate, argininosuccinate, and L-arginine, the substrate of nitric oxide (NO) synthase.	Oxaloacetic Acid	163-175	fumarate hydratase	Rattus norvegicus	53-61
28809118-5	2017	Our metabolomics analysis indicates that glutamine is the major source of oxaloacetate in S2-013.Neo and S2-013.MUC1 cells, where oxaloacetate is converted to aspartate, an important metabolite for pyrimidine nucleotide biosynthesis.	Oxaloacetic Acid	74-86	mucin 1, cell surface associated	Homo sapiens	112-116
27390019-7	2017	The disruptive effects of a general inhibitor of excitatory amino acid transport or TNFalpha, a pro-inflammatory mediator of Abeta action, were also reversed by oxaloacetate.	Oxaloacetic Acid	161-173	tumor necrosis factor	Rattus norvegicus	84-92
28166201-3	2017	Here we show that mitochondrial phosphoenolpyruvate carboxykinase (PCK2), the hub molecule linking tricarboxylic acid (TCA) cycle, glycolysis and gluconeogenesis by conversion of mitochondrial oxaloacetate (OAA) to phosphoenolpyruvate, regulates glucose carbon flow direction in stem-like cells that repopulate tumors (tumor-repopulating cells (TRCs)).	Oxaloacetic Acid	193-205	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	67-71
28166201-3	2017	Here we show that mitochondrial phosphoenolpyruvate carboxykinase (PCK2), the hub molecule linking tricarboxylic acid (TCA) cycle, glycolysis and gluconeogenesis by conversion of mitochondrial oxaloacetate (OAA) to phosphoenolpyruvate, regulates glucose carbon flow direction in stem-like cells that repopulate tumors (tumor-repopulating cells (TRCs)).	Oxaloacetic Acid	207-210	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	67-71
28322963-0	2017	The effect of oxaloacetic acid on tyrosinase activity and structure: Integration of inhibition kinetics with docking simulation.	Oxaloacetic Acid	14-30	tyrosinase	Homo sapiens	34-44
28606087-1	2017	BACKGROUND: Aspartate, which is converted from oxaloacetate (OAA) by aspartate aminotransferase, is considered an important precursor for purine salvage and pyrimidine de novo biosynthesis, and is thus indispensable for the growth of Plasmodium parasites at the asexual blood stages.	Oxaloacetic Acid	47-59	PBANKA_030230	Plasmodium berghei ANKA	69-95
28606087-1	2017	BACKGROUND: Aspartate, which is converted from oxaloacetate (OAA) by aspartate aminotransferase, is considered an important precursor for purine salvage and pyrimidine de novo biosynthesis, and is thus indispensable for the growth of Plasmodium parasites at the asexual blood stages.	Oxaloacetic Acid	61-64	PBANKA_030230	Plasmodium berghei ANKA	69-95
28413446-3	2017	We down-regulated the expression of phosphoenolpyruvate carboxylase (PEPC), which catalyzes the formation of oxaloacetate from phosphoenolpyruvate and regulates carbon flux.	Oxaloacetic Acid	109-121	uncharacterized protein	Chlamydomonas reinhardtii	36-67
28413446-3	2017	We down-regulated the expression of phosphoenolpyruvate carboxylase (PEPC), which catalyzes the formation of oxaloacetate from phosphoenolpyruvate and regulates carbon flux.	Oxaloacetic Acid	109-121	uncharacterized protein	Chlamydomonas reinhardtii	69-73
28314989-7	2017	GOT1 is responsible for the conversion of glutamine-derived aspartate into OAA, which subsequently can be converted into malate and pyruvate.	Oxaloacetic Acid	75-78	glutamic-oxaloacetic transaminase 1	Homo sapiens	0-4
27989324-1	2017	MDH2 encodes mitochondrial malate dehydrogenase (MDH), which is essential for the conversion of malate to oxaloacetate as part of the proper functioning of the Krebs cycle.	Oxaloacetic Acid	106-118	malate dehydrogenase 2	Homo sapiens	0-4
27780757-4	2017	In this work we hypothesized that the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) could be improved by a controlled expression of the human mitochondrial GTP-dependent PEP carboxykinase.	Oxaloacetic Acid	52-64	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	186-203
27780757-4	2017	In this work we hypothesized that the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) could be improved by a controlled expression of the human mitochondrial GTP-dependent PEP carboxykinase.	Oxaloacetic Acid	66-69	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	186-203
27890529-5	2017	Strong PC suppression lowered glucose incorporation into downstream metabolites of oxaloacetate, the product of the PC reaction, including malate, citrate and aspartate.	Oxaloacetic Acid	83-95	pyruvate carboxylase	Homo sapiens	7-9
27890529-5	2017	Strong PC suppression lowered glucose incorporation into downstream metabolites of oxaloacetate, the product of the PC reaction, including malate, citrate and aspartate.	Oxaloacetic Acid	83-95	pyruvate carboxylase	Homo sapiens	116-118
27746301-2	2017	It was generally thought that the AOX pathway protects photosystems by dissipating excess reducing equivalents exported from chloroplasts through the malate/oxaloacetate (Mal/OAA) shuttle and thus preventing the over-reduction of chloroplasts.	Oxaloacetic Acid	157-169	alternative oxidase 2	Arabidopsis thaliana	34-37
27451147-11	2016	Incubation of KRAS mutant CRC cells with knockdown of SLC25A22 with aspartate increased proliferation and reduced apoptosis, which required GOT1, indicating that oxaloacetate is required for cell survival.	Oxaloacetic Acid	162-174	KRAS proto-oncogene, GTPase	Homo sapiens	14-18
27816553-3	2017	Additionally, OAA inhibited serum and potassium deprivation-induced caspase 3 activation.	Oxaloacetic Acid	14-17	caspase 3	Homo sapiens	68-77
27816553-5	2017	Clearly, different from ASC-CM-induced neuroprotection, OAA-induced neuroprotection was Akt- independent but JNK-dependent.	Oxaloacetic Acid	56-59	mitogen-activated protein kinase 8	Homo sapiens	109-112
29055942-8	2017	Oxaloacetate was found as an additional substrate of EAAT3.	Oxaloacetic Acid	0-12	solute carrier family 1 member 1	Homo sapiens	53-58
27769451-2	2016	Our biosensing approach provides an especial and significant detection mechanism: CS can catalyze the essential condensation reaction between acetyl-coenzyme A (Ac-CoA) and oxaloacetate (OAA) to form citrate and CoA; then, in the presence of Ag(I), CoA-Ag(I) CP can be in situ formed because of the strong complexation ability of thiol groups of CoA toward Ag(I).	Oxaloacetic Acid	173-185	citrate synthase	Homo sapiens	82-84
27769451-2	2016	Our biosensing approach provides an especial and significant detection mechanism: CS can catalyze the essential condensation reaction between acetyl-coenzyme A (Ac-CoA) and oxaloacetate (OAA) to form citrate and CoA; then, in the presence of Ag(I), CoA-Ag(I) CP can be in situ formed because of the strong complexation ability of thiol groups of CoA toward Ag(I).	Oxaloacetic Acid	187-190	citrate synthase	Homo sapiens	82-84
27451147-11	2016	Incubation of KRAS mutant CRC cells with knockdown of SLC25A22 with aspartate increased proliferation and reduced apoptosis, which required GOT1, indicating that oxaloacetate is required for cell survival.	Oxaloacetic Acid	162-174	solute carrier family 25 member 22	Homo sapiens	54-62
27451147-12	2016	Decreased levels of oxaloacetate in cells with knockdown of SLC25A22 reduced regeneration of oxidized nicotinamide adenine dinucleotide and reduced nicotinamide adenine dinucleotide phosphate.	Oxaloacetic Acid	20-32	solute carrier family 25 member 22	Homo sapiens	60-68
28955961-7	2016	The mouse KAT3 is more efficient in transamination of glutamine with indo-3-pyruvate or oxaloacetate as amino group acceptor than the mouse KAT1.	Oxaloacetic Acid	88-100	kynurenine aminotransferase 3	Mus musculus	10-14
27732858-2	2016	The two major anaplerotic pathways in cells are pyruvate conversion to oxaloacetate via pyruvate carboxylase (PC) and glutamine conversion to alpha-ketoglutarate.	Oxaloacetic Acid	71-83	pyruvate carboxylase	Homo sapiens	88-108
27732858-2	2016	The two major anaplerotic pathways in cells are pyruvate conversion to oxaloacetate via pyruvate carboxylase (PC) and glutamine conversion to alpha-ketoglutarate.	Oxaloacetic Acid	71-83	pyruvate carboxylase	Homo sapiens	110-112
26889011-1	2016	Mitochondrial malate dehydrogenase (mMDH) catalyses the interconversion of malate and oxaloacetate (OAA) in the tricarboxylic acid (TCA) cycle.	Oxaloacetic Acid	86-98	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	36-40
27265727-4	2016	Mechanistically, p53 activation represses the expression of the mitochondrial enzyme pyruvate carboxylase (PC), resulting in diminished production of the TCA cycle intermediates oxaloacetate and NADPH, and impaired oxygen consumption.	Oxaloacetic Acid	178-190	transformation related protein 53, pseudogene	Mus musculus	17-20
27265727-4	2016	Mechanistically, p53 activation represses the expression of the mitochondrial enzyme pyruvate carboxylase (PC), resulting in diminished production of the TCA cycle intermediates oxaloacetate and NADPH, and impaired oxygen consumption.	Oxaloacetic Acid	178-190	pyruvate carboxylase	Mus musculus	85-105
27086848-3	2016	Following doxorubicin administration, TNBC cells acquire metabolic alteration, causing increased glutamine flux for the synthesis of aspartate which can be converted into OAA by GOT1.	Oxaloacetic Acid	171-174	glutamic-oxaloacetic transaminase 1	Homo sapiens	178-182
27493727-7	2016	Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate.	Oxaloacetic Acid	105-117	pyruvate carboxylase	Homo sapiens	26-28
27493727-7	2016	Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate.	Oxaloacetic Acid	105-117	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	270-293
27493727-7	2016	Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate.	Oxaloacetic Acid	105-117	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	295-298
27493727-7	2016	Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate.	Oxaloacetic Acid	221-233	pyruvate carboxylase	Homo sapiens	26-28
26983943-2	2016	Pyruvate kinase (PYK) defect is one of the strategies used to enhance the supply of oxaloacetic acid (OAA), a precursor metabolite for lysine biosynthesis.	Oxaloacetic Acid	84-100	pyruvate kinase	Corynebacterium glutamicum ATCC 13032	0-15
26983943-2	2016	Pyruvate kinase (PYK) defect is one of the strategies used to enhance the supply of oxaloacetic acid (OAA), a precursor metabolite for lysine biosynthesis.	Oxaloacetic Acid	84-100	pyruvate kinase	Corynebacterium glutamicum ATCC 13032	17-20
26983943-2	2016	Pyruvate kinase (PYK) defect is one of the strategies used to enhance the supply of oxaloacetic acid (OAA), a precursor metabolite for lysine biosynthesis.	Oxaloacetic Acid	102-105	pyruvate kinase	Corynebacterium glutamicum ATCC 13032	0-15
26983943-2	2016	Pyruvate kinase (PYK) defect is one of the strategies used to enhance the supply of oxaloacetic acid (OAA), a precursor metabolite for lysine biosynthesis.	Oxaloacetic Acid	102-105	pyruvate kinase	Corynebacterium glutamicum ATCC 13032	17-20
26983943-7	2016	Therefore, the pyk deletion is effective under a PEPC-desensitized background, which ensures enhanced supply of OAA, thus clarifying the discrepancies.	Oxaloacetic Acid	112-115	pyruvate kinase	Corynebacterium glutamicum ATCC 13032	15-18
26983943-7	2016	Therefore, the pyk deletion is effective under a PEPC-desensitized background, which ensures enhanced supply of OAA, thus clarifying the discrepancies.	Oxaloacetic Acid	112-115	phosphoenolpyruvate carboxylase	Corynebacterium glutamicum ATCC 13032	49-53
27068062-6	2016	With malate alone, oxaloacetate accumulation limited NADH production by MDH unless glutamate was also added to promote oxaloacetate removal via AST.	Oxaloacetic Acid	19-31	malic enzyme 1	Homo sapiens	72-75
27068062-6	2016	With malate alone, oxaloacetate accumulation limited NADH production by MDH unless glutamate was also added to promote oxaloacetate removal via AST.	Oxaloacetic Acid	119-131	solute carrier family 17 member 5	Homo sapiens	144-147
27068062-9	2016	CoA depletion decreased KG oxidation by alpha-ketoglutarate dehydrogenase (KGDH), such that the resulting increase in [KG] inhibited oxaloacetate removal by AST and NADH generation by MDH.	Oxaloacetic Acid	133-145	solute carrier family 17 member 5	Homo sapiens	157-160
27208265-1	2016	Mitochondrial malate dehydrogenase (mMDH; EC 1.1.1.37) has multiple roles; the most commonly described is its catalysis of the interconversion of malate and oxaloacetate in the tricarboxylic acid cycle.	Oxaloacetic Acid	157-169	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	36-40
26889011-1	2016	Mitochondrial malate dehydrogenase (mMDH) catalyses the interconversion of malate and oxaloacetate (OAA) in the tricarboxylic acid (TCA) cycle.	Oxaloacetic Acid	100-103	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	36-40
26168906-1	2016	Phosphoenolpyruvate carboxylase (PEPC) in Corynebacterium glutamicum ATCC13032, a glutamic-acid producing actinobacterium, is subject to feedback inhibition by metabolic intermediates such as aspartic acid and 2-oxoglutaric acid, which implies the importance of PEPC in replenishing oxaloacetic acid into the TCA cycle.	Oxaloacetic Acid	283-299	phosphoenolpyruvate carboxylase	Corynebacterium glutamicum ATCC 13032	0-31
26811028-7	2016	Cytosolic malate dehydrogenase 1 protein increased with OAA treatment, but not with malate or glucose deprivation.	Oxaloacetic Acid	56-59	malate dehydrogenase 1	Homo sapiens	10-32
26811028-10	2016	OAA increased total and phosphorylated SIRT1 protein.	Oxaloacetic Acid	0-3	sirtuin 1	Homo sapiens	39-44
26168906-1	2016	Phosphoenolpyruvate carboxylase (PEPC) in Corynebacterium glutamicum ATCC13032, a glutamic-acid producing actinobacterium, is subject to feedback inhibition by metabolic intermediates such as aspartic acid and 2-oxoglutaric acid, which implies the importance of PEPC in replenishing oxaloacetic acid into the TCA cycle.	Oxaloacetic Acid	283-299	phosphoenolpyruvate carboxylase	Corynebacterium glutamicum ATCC 13032	33-37
26168906-1	2016	Phosphoenolpyruvate carboxylase (PEPC) in Corynebacterium glutamicum ATCC13032, a glutamic-acid producing actinobacterium, is subject to feedback inhibition by metabolic intermediates such as aspartic acid and 2-oxoglutaric acid, which implies the importance of PEPC in replenishing oxaloacetic acid into the TCA cycle.	Oxaloacetic Acid	283-299	phosphoenolpyruvate carboxylase	Corynebacterium glutamicum ATCC 13032	262-266
25982115-4	2015	Moreover, in vitro analysis demonstrates that oxaloacetate regenerated through the glyoxylate cycle induces a conformational change in citrate synthase and inhibits its recognition and ubiquitination by SCF(Ucc1), suggesting the existence of an oxaloacetate-dependent positive feedback loop that stabilizes citrate synthase.	Oxaloacetic Acid	46-58	citrate synthase	Homo sapiens	135-151
26439318-4	2016	To increase the yield of malic acid by the muC strain significantly, the carbon flux from pyruvate was redirected to oxaloacetate by expressing an exogenous pyruvate carboxylase (PCx) gene from Corynebacterium glutamicum ATCC 13032 in the chromosome of T. fusca muC-16.	Oxaloacetic Acid	117-129	pyruvate carboxylase	Corynebacterium glutamicum ATCC 13032	157-177
26439318-4	2016	To increase the yield of malic acid by the muC strain significantly, the carbon flux from pyruvate was redirected to oxaloacetate by expressing an exogenous pyruvate carboxylase (PCx) gene from Corynebacterium glutamicum ATCC 13032 in the chromosome of T. fusca muC-16.	Oxaloacetic Acid	117-129	pyruvate carboxylase	Corynebacterium glutamicum ATCC 13032	179-182
26570984-4	2016	Oral administration of OAA decreased the clinical arthritis symptoms, paw thickness, histologic and radiologic changes, and serum total and anti-type II collagen IgG, IgG1, and IgG2a levels.	Oxaloacetic Acid	23-26	LOC105243590	Mus musculus	167-171
26570984-4	2016	Oral administration of OAA decreased the clinical arthritis symptoms, paw thickness, histologic and radiologic changes, and serum total and anti-type II collagen IgG, IgG1, and IgG2a levels.	Oxaloacetic Acid	23-26	immunoglobulin heavy variable V1-9	Mus musculus	177-182
26570984-5	2016	OAA administration reduced Th1/Th17 phenotype CD4(+) T lymphocyte expansions and inflammatory cytokine productions in T cell activated draining lymph nodes and spleen.	Oxaloacetic Acid	0-3	negative elongation factor complex member C/D, Th1l	Mus musculus	27-30
26269598-1	2015	Phosphoenolpyruvate carboxykinase (PEPCK) is one of the pivotal enzymes that regulates the carbon flow of the central metabolism by fixing CO2 to phosphoenolpyruvate (PEP) to produce oxaloacetate or vice versa.	Oxaloacetic Acid	183-195	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	35-40
25284589-11	2015	Gln starvation markedly increases ROS levels in Hace1(-/-) but not in wt MEFs, and treatment with the antioxidant N-acetyl cysteine or the TCA cycle intermediate oxaloacetate efficiently rescues Gln starvation-induced ROS elevation and cell death in Hace1(-/-) MEFs.	Oxaloacetic Acid	162-174	HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1	Mus musculus	48-53
25284589-11	2015	Gln starvation markedly increases ROS levels in Hace1(-/-) but not in wt MEFs, and treatment with the antioxidant N-acetyl cysteine or the TCA cycle intermediate oxaloacetate efficiently rescues Gln starvation-induced ROS elevation and cell death in Hace1(-/-) MEFs.	Oxaloacetic Acid	162-174	HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1	Mus musculus	250-255
25982115-4	2015	Moreover, in vitro analysis demonstrates that oxaloacetate regenerated through the glyoxylate cycle induces a conformational change in citrate synthase and inhibits its recognition and ubiquitination by SCF(Ucc1), suggesting the existence of an oxaloacetate-dependent positive feedback loop that stabilizes citrate synthase.	Oxaloacetic Acid	46-58	KIT ligand	Homo sapiens	203-206
25982115-4	2015	Moreover, in vitro analysis demonstrates that oxaloacetate regenerated through the glyoxylate cycle induces a conformational change in citrate synthase and inhibits its recognition and ubiquitination by SCF(Ucc1), suggesting the existence of an oxaloacetate-dependent positive feedback loop that stabilizes citrate synthase.	Oxaloacetic Acid	46-58	ependymin related 1	Homo sapiens	207-211
25982115-4	2015	Moreover, in vitro analysis demonstrates that oxaloacetate regenerated through the glyoxylate cycle induces a conformational change in citrate synthase and inhibits its recognition and ubiquitination by SCF(Ucc1), suggesting the existence of an oxaloacetate-dependent positive feedback loop that stabilizes citrate synthase.	Oxaloacetic Acid	46-58	citrate synthase	Homo sapiens	307-323
25982115-4	2015	Moreover, in vitro analysis demonstrates that oxaloacetate regenerated through the glyoxylate cycle induces a conformational change in citrate synthase and inhibits its recognition and ubiquitination by SCF(Ucc1), suggesting the existence of an oxaloacetate-dependent positive feedback loop that stabilizes citrate synthase.	Oxaloacetic Acid	245-257	citrate synthase	Homo sapiens	135-151
25982115-4	2015	Moreover, in vitro analysis demonstrates that oxaloacetate regenerated through the glyoxylate cycle induces a conformational change in citrate synthase and inhibits its recognition and ubiquitination by SCF(Ucc1), suggesting the existence of an oxaloacetate-dependent positive feedback loop that stabilizes citrate synthase.	Oxaloacetic Acid	245-257	KIT ligand	Homo sapiens	203-206
26070193-1	2015	Pyruvate carboxylase (PC) is an anaplerotic enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, which is crucial for replenishing tricarboxylic acid cycle intermediates when they are used for biosynthetic purposes.	Oxaloacetic Acid	99-111	pyruvate carboxylase	Homo sapiens	0-20
26070193-1	2015	Pyruvate carboxylase (PC) is an anaplerotic enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, which is crucial for replenishing tricarboxylic acid cycle intermediates when they are used for biosynthetic purposes.	Oxaloacetic Acid	99-111	pyruvate carboxylase	Homo sapiens	22-24
32262409-2	2015	In the presence of nicotinamide adenine dinucleotide as a cofactor, oxaloacetic acid is converted by malate dehydrogenase into l-malic acid.	Oxaloacetic Acid	68-84	malic enzyme 2	Homo sapiens	101-121
26039450-2	2015	ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes mitochondria-derived citrate into oxaloacetate and acetyl-CoA.	Oxaloacetic Acid	95-107	ATP citrate lyase	Homo sapiens	0-17
26039450-2	2015	ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes mitochondria-derived citrate into oxaloacetate and acetyl-CoA.	Oxaloacetic Acid	95-107	ATP citrate lyase	Homo sapiens	19-22
26221340-2	2015	ATP citrate lyase (ACLY) is generally recognized as a key enzyme of de novo fatty acid synthesis responsible for generation of oxaloacetate and cytosolic acetyl-CoA.	Oxaloacetic Acid	127-139	ATP citrate lyase	Homo sapiens	0-17
26221340-2	2015	ATP citrate lyase (ACLY) is generally recognized as a key enzyme of de novo fatty acid synthesis responsible for generation of oxaloacetate and cytosolic acetyl-CoA.	Oxaloacetic Acid	127-139	ATP citrate lyase	Homo sapiens	19-23
25701462-1	2015	ATP citrate lyase (ACLY) is responsible for the conversion of cytosolic citrate into acetyl-CoA and oxaloacetate, and the first rate-limiting enzyme involved in de novo lipogenesis.	Oxaloacetic Acid	100-112	ATP citrate lyase	Homo sapiens	0-17
25701462-1	2015	ATP citrate lyase (ACLY) is responsible for the conversion of cytosolic citrate into acetyl-CoA and oxaloacetate, and the first rate-limiting enzyme involved in de novo lipogenesis.	Oxaloacetic Acid	100-112	ATP citrate lyase	Homo sapiens	19-23
25545012-1	2014	Citrate synthase (CS), one of the key enzymes in the tricarboxylic acid (TCA) cycle, catalyzes the reaction between oxaloacetic acid and acetyl coenzyme A to generate citrate.	Oxaloacetic Acid	116-132	citrate synthase	Homo sapiens	0-16
25367309-1	2015	ATP citrate lyase (ACLY) is a key enzyme that is involved in de novo lipogenesis by catalyzing conversion of cytosolic citrate into acetyl CoA and oxaloacetate.	Oxaloacetic Acid	147-159	ATP citrate lyase	Homo sapiens	0-17
25367309-1	2015	ATP citrate lyase (ACLY) is a key enzyme that is involved in de novo lipogenesis by catalyzing conversion of cytosolic citrate into acetyl CoA and oxaloacetate.	Oxaloacetic Acid	147-159	ATP citrate lyase	Homo sapiens	19-23
25606688-1	2015	The kinetics of malate dehydrogenase (MDH) catalyzed oxidation/reduction of L-malate/oxaloacetate is pH-dependent due to the proton generated/taken up during the reaction.	Oxaloacetic Acid	85-97	malic enzyme 2	Homo sapiens	16-36
25606689-3	2015	Two isoenzymes of malate dehydrogenase (MDH) operate as components of the malate-aspartate shuttle, in which a reducing equivalent is transported via malate, which when oxidized to oxaloacetate, transfers an electron pair to reduce NAD to NADH.	Oxaloacetic Acid	181-193	malic enzyme 1	Homo sapiens	18-38
25606689-3	2015	Two isoenzymes of malate dehydrogenase (MDH) operate as components of the malate-aspartate shuttle, in which a reducing equivalent is transported via malate, which when oxidized to oxaloacetate, transfers an electron pair to reduce NAD to NADH.	Oxaloacetic Acid	181-193	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	40-43
25537655-1	2015	ATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA.	Oxaloacetic Acid	146-162	ATP citrate lyase	Homo sapiens	0-17
25537655-1	2015	ATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA.	Oxaloacetic Acid	146-162	ATP citrate lyase	Homo sapiens	19-23
25537655-1	2015	ATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA.	Oxaloacetic Acid	164-167	ATP citrate lyase	Homo sapiens	0-17
25537655-1	2015	ATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA.	Oxaloacetic Acid	164-167	ATP citrate lyase	Homo sapiens	19-23
25545012-1	2014	Citrate synthase (CS), one of the key enzymes in the tricarboxylic acid (TCA) cycle, catalyzes the reaction between oxaloacetic acid and acetyl coenzyme A to generate citrate.	Oxaloacetic Acid	116-132	citrate synthase	Homo sapiens	18-20
28649521-1	2015	Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA) cycle with oxaloacetate.	Oxaloacetic Acid	261-273	pyruvate carboxylase	Homo sapiens	0-20
28649521-1	2015	Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA) cycle with oxaloacetate.	Oxaloacetic Acid	261-273	pyruvate carboxylase	Homo sapiens	22-24
28649521-1	2015	Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA) cycle with oxaloacetate.	Oxaloacetic Acid	115-127	pyruvate carboxylase	Homo sapiens	0-20
28649521-1	2015	Pyruvate carboxylase (PC) is a biotin-containing mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, thereby being involved in gluconeogenesis and in energy production through replenishment of the tricarboxylic acid (TCA) cycle with oxaloacetate.	Oxaloacetic Acid	115-127	pyruvate carboxylase	Homo sapiens	22-24
25240193-2	2014	While TR4 overexpression increased PC activity, oxaloacetate (OAA) and glycerol levels with enhanced incorporation of (14)C from (14)C-pyruvate into fatty acids in 3T3-L1 adipocytes, PC knockdown by short interfering RNA (siRNA) or inhibition of PC activity by phenylacetic acid (PAA) abolished TR4-enhanced fatty acid synthesis.	Oxaloacetic Acid	48-60	nuclear receptor subfamily 2, group C, member 2	Mus musculus	6-9
25240193-2	2014	While TR4 overexpression increased PC activity, oxaloacetate (OAA) and glycerol levels with enhanced incorporation of (14)C from (14)C-pyruvate into fatty acids in 3T3-L1 adipocytes, PC knockdown by short interfering RNA (siRNA) or inhibition of PC activity by phenylacetic acid (PAA) abolished TR4-enhanced fatty acid synthesis.	Oxaloacetic Acid	62-65	nuclear receptor subfamily 2, group C, member 2	Mus musculus	6-9
24882745-1	2014	The tetrameric enzyme pyruvate carboxylase (PC), a biotin-dependent carboxylase, produces oxaloacetate by two consecutive reactions that take place in distant active sites.	Oxaloacetic Acid	90-102	AT695_RS12140	Staphylococcus aureus	22-42
24560882-8	2014	In presence of HL, the transcript levels of several genes related to antioxidant, malate-oxaloacetate (malate-OAA) shuttle, photorespiratory and respiratory enzymes was higher in aox1a compared to WT.	Oxaloacetic Acid	110-113	alternative oxidase 1A	Arabidopsis thaliana	179-184
24963911-1	2014	Pyruvate carboxylase (PC) catalyzes the carboxylation of pyruvate to produce oxaloacetate.	Oxaloacetic Acid	77-89	AT695_RS12140	Staphylococcus aureus	0-20
24963911-1	2014	Pyruvate carboxylase (PC) catalyzes the carboxylation of pyruvate to produce oxaloacetate.	Oxaloacetic Acid	77-89	AT695_RS12140	Staphylococcus aureus	22-24
25242145-3	2014	CS suppression reduced TCA cycle activity and diverted oxaloacetate, the substrate of CS, into production of the nonessential amino acids aspartate and asparagine.	Oxaloacetic Acid	55-67	citrate synthase	Homo sapiens	0-2
25242145-3	2014	CS suppression reduced TCA cycle activity and diverted oxaloacetate, the substrate of CS, into production of the nonessential amino acids aspartate and asparagine.	Oxaloacetic Acid	55-67	citrate synthase	Homo sapiens	86-88
24973213-1	2014	Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M), encoded by the nuclear PCK2 gene, links TCA cycle intermediates and glycolytic pools through the conversion of mitochondrial oxaloacetate into phosphoenolpyruvate.	Oxaloacetic Acid	184-196	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	49-56
24973213-1	2014	Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M), encoded by the nuclear PCK2 gene, links TCA cycle intermediates and glycolytic pools through the conversion of mitochondrial oxaloacetate into phosphoenolpyruvate.	Oxaloacetic Acid	184-196	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	82-86
24882745-1	2014	The tetrameric enzyme pyruvate carboxylase (PC), a biotin-dependent carboxylase, produces oxaloacetate by two consecutive reactions that take place in distant active sites.	Oxaloacetic Acid	90-102	AT695_RS12140	Staphylococcus aureus	44-46
24882745-3	2014	We have analyzed PC samples from Staphylococcus aureus while the enzyme generates oxaloacetate, expecting PC tetramers to display the conformational landscape relevant for its functioning.	Oxaloacetic Acid	82-94	AT695_RS12140	Staphylococcus aureus	17-19
24395786-7	2014	UCP2 reconstituted in lipid vesicles catalyzed the exchange of malate, oxaloacetate, and aspartate for phosphate plus a proton from opposite sides of the membrane.	Oxaloacetic Acid	71-83	uncoupling protein 2	Homo sapiens	0-4
24616091-1	2014	The Burkholderia species utilize acetyl-CoA and oxaloacetate, substrates for citrate synthase in the TCA cycle, to produce oxalic acid in response to bacterial cell to cell communication, called quorum sensing.	Oxaloacetic Acid	48-60	citrate synthase	Homo sapiens	77-93
24361669-7	2014	Interestingly, OAA significantly inhibited Btk phosphorylation, phospholipase Cgamma2 (PLCgamma2) phosphorylation, calcium ion (Ca(2+)) oscillation, and nuclear factor of activated T cell c1 (NFATc1) expression in RANKL-stimulated BMMs, but did not affect RANKL-induced mitogen-activated protein kinase.	Oxaloacetic Acid	15-18	phospholipase C, gamma 2	Mus musculus	87-96
24361669-7	2014	Interestingly, OAA significantly inhibited Btk phosphorylation, phospholipase Cgamma2 (PLCgamma2) phosphorylation, calcium ion (Ca(2+)) oscillation, and nuclear factor of activated T cell c1 (NFATc1) expression in RANKL-stimulated BMMs, but did not affect RANKL-induced mitogen-activated protein kinase.	Oxaloacetic Acid	15-18	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	192-198
24361669-10	2014	Taken together, the results suggested that OAA inhibited RANKL-mediated osteoclastogenesis via PLCgamma2-Ca(2+)-NFATc1 signaling in vitro and suppressed inflammatory bone loss in vivo.	Oxaloacetic Acid	43-46	phospholipase C, gamma 2	Mus musculus	95-104
24361669-10	2014	Taken together, the results suggested that OAA inhibited RANKL-mediated osteoclastogenesis via PLCgamma2-Ca(2+)-NFATc1 signaling in vitro and suppressed inflammatory bone loss in vivo.	Oxaloacetic Acid	43-46	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	112-118
24453164-2	2014	Excess electrons from photosynthetic electron transport in the form of nicotinamide adenine dinucleotide phosphate, reduced are used by NADP-dependent malate dehydrogenase (MDH) to reduce OAA to malate, thus regenerating the electron acceptor NADP.	Oxaloacetic Acid	188-191	lactate/malate dehydrogenase family protein	Arabidopsis thaliana	136-171
23900421-4	2013	The level of tricarboxylic acid cycle intermediates, including malate and oxaloacetate, and the NADH-to-NAD(+) ratio are perturbed in the liver of Gcn2 KO mice either in the fed or fasted state, which may directly impinge upon GNG.	Oxaloacetic Acid	74-86	eukaryotic translation initiation factor 2 alpha kinase 4	Mus musculus	147-151
24407245-0	2014	Human recombinant glutamate oxaloacetate transaminase 1 (GOT1) supplemented with oxaloacetate induces a protective effect after cerebral ischemia.	Oxaloacetic Acid	28-40	glutamic-oxaloacetic transaminase 1	Homo sapiens	57-61
24407245-2	2014	Glutamate oxaloacetate transaminase 1 (GOT1) activation by means of oxaloacetate administration has been used to reduce the glutamate concentration in the blood.	Oxaloacetic Acid	10-22	glutamic-oxaloacetic transaminase 1	Homo sapiens	39-43
23897470-5	2013	Previous studies have shown that mammalian Nit2 (also a putative tumour suppressor) is identical to omega-amidase, an enzyme that catalyzes the hydrolysis of alpha-ketoglutaramate (alpha-KGM) and alpha-ketosuccinamate (alpha-KSM) to alpha-ketoglutarate (alpha-KG) and oxaloacetate (OA), respectively.	Oxaloacetic Acid	268-280	nitrilase family member 2	Homo sapiens	43-47
23892740-8	2013	Through transcriptome analysis, a binding site similar to the one of the Saccharomyces cerevisiae yeast transcription factor Msn2/4 was identified in the upstream regions of glycolytic genes and the cytosolic malic acid production pathway from pyruvate via oxaloacetate to malate, which suggests that malic acid production is a stress response.	Oxaloacetic Acid	257-269	stress-responsive transcriptional activator MSN2	Saccharomyces cerevisiae S288C	125-129
23897470-5	2013	Previous studies have shown that mammalian Nit2 (also a putative tumour suppressor) is identical to omega-amidase, an enzyme that catalyzes the hydrolysis of alpha-ketoglutaramate (alpha-KGM) and alpha-ketosuccinamate (alpha-KSM) to alpha-ketoglutarate (alpha-KG) and oxaloacetate (OA), respectively.	Oxaloacetic Acid	282-284	nitrilase family member 2	Homo sapiens	43-47
23499868-4	2013	The oral administration of OAA over a four-week period attenuated AD symptoms in terms of decreased skin lesions, epidermal thickness, the infiltration of immune cells (CD4+ cells, eosinophils, and mast cells), and serum IgE, IgG2a, and histamine levels.	Oxaloacetic Acid	27-30	immunoglobulin heavy variable V1-9	Mus musculus	226-231
23624997-1	2013	The interactions between oxaloacetic (OAA) and phosphoenolpyruvic carboxykinase (PEPCK) binding pocket in the presence and absence of hydrazine were carried out using quantum chemical calculations, based on the two-layered ONIOM (ONIOM2) approach.	Oxaloacetic Acid	38-41	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	47-79
23624997-1	2013	The interactions between oxaloacetic (OAA) and phosphoenolpyruvic carboxykinase (PEPCK) binding pocket in the presence and absence of hydrazine were carried out using quantum chemical calculations, based on the two-layered ONIOM (ONIOM2) approach.	Oxaloacetic Acid	38-41	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	81-86
23698000-2	2013	Pyruvate carboxylase (PC), a multifunctional biotin-dependent enzyme, catalyzes the bicarbonate- and MgATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues.	Oxaloacetic Acid	146-158	pyruvate carboxylase	Homo sapiens	0-20
23698000-2	2013	Pyruvate carboxylase (PC), a multifunctional biotin-dependent enzyme, catalyzes the bicarbonate- and MgATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues.	Oxaloacetic Acid	146-158	pyruvate carboxylase	Homo sapiens	22-24
23466304-11	2013	When PEPCK-M was expressed in the presence of PEPCK-C, the mitochondrial isozyme amplified total gluconeogenic capacity, suggesting autonomous regulation of oxaloacetate to phosphoenolpyruvate fluxes by the individual isoforms.	Oxaloacetic Acid	157-169	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	Mus musculus	5-12
23466304-11	2013	When PEPCK-M was expressed in the presence of PEPCK-C, the mitochondrial isozyme amplified total gluconeogenic capacity, suggesting autonomous regulation of oxaloacetate to phosphoenolpyruvate fluxes by the individual isoforms.	Oxaloacetic Acid	157-169	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	46-53
23499868-6	2013	The oral administration of OAA over a three-day period attenuated ACD symptoms in terms of ear thickness, lymphocyte proliferation, and serum IgG2a levels.	Oxaloacetic Acid	27-30	immunoglobulin heavy variable V1-9	Mus musculus	142-147
22971926-2	2012	Cytosolic malate dehydrogenase (MDH1) catalyzes the reversible reduction of oxaloacetate to malate at the expense of reduced nicotinamide adenine dinucleotide (NADH).	Oxaloacetic Acid	76-88	malate dehydrogenase 1	Homo sapiens	0-30
23535601-5	2013	Whereas most cells use glutamate dehydrogenase (GLUD1) to convert glutamine-derived glutamate into alpha-ketoglutarate in the mitochondria to fuel the tricarboxylic acid cycle, PDAC relies on a distinct pathway in which glutamine-derived aspartate is transported into the cytoplasm where it can be converted into oxaloacetate by aspartate transaminase (GOT1).	Oxaloacetic Acid	313-325	glutamate dehydrogenase 1	Homo sapiens	48-53
23472183-2	2013	Malate can be synthesized from fumarate by the enzyme fumarase and further oxidized to oxaloacetate by malate dehydrogenase with the accompanying reduction of NAD.	Oxaloacetic Acid	87-99	putative fumarate hydratase, mitochondrial	Caenorhabditis elegans	54-62
22682085-3	2012	Insulin resistance is important in various states such as starvation, immune activation, growth and cancer, to spare glucose for different biosynthetic purposes such as the production of NADPH, nucleotides in the pentose phosphate pathway and oxaloacetate for anaplerosis.	Oxaloacetic Acid	243-255	insulin	Homo sapiens	0-7
22971926-2	2012	Cytosolic malate dehydrogenase (MDH1) catalyzes the reversible reduction of oxaloacetate to malate at the expense of reduced nicotinamide adenine dinucleotide (NADH).	Oxaloacetic Acid	76-88	malate dehydrogenase 1	Homo sapiens	32-36
22674578-2	2012	hNit2/omega-amidase plays a crucial metabolic role by catalyzing the hydrolysis of alpha-ketoglutaramate (the alpha-keto analog of glutamine) and alpha-ketosuccinamate (the alpha-keto analog of asparagine), yielding alpha-ketoglutarate and oxaloacetate, respectively.	Oxaloacetic Acid	240-252	nitrilase family member 2	Homo sapiens	0-5
23098296-1	2012	Pyruvate carboxylase [EC 6.4.1.1] plays an important anaplerotic role in many species by catalyzing the carboxylation of pyruvate to oxaloacetate.	Oxaloacetic Acid	133-145	pyruvate carboxylase	Homo sapiens	0-20
22429403-1	2012	BACKGROUND: It is known that excess reducing equivalents in the form of NADPH in chloroplasts can be transported via shuttle machineries, such as the malate-oxaloacetate (OAA) shuttle, into the mitochondria, where they are efficiently oxidised by the mitochondrial alternative oxidase (AOX) respiratory pathway.	Oxaloacetic Acid	171-174	acyl-CoA oxidase 1	Homo sapiens	286-289
22657152-1	2012	ATP citrate lyase (ACL) catalyzes an ATP-dependent biosynthetic reaction which produces acetyl-coenzyme A and oxaloacetate from citrate and coenzyme A (CoA).	Oxaloacetic Acid	110-122	ATP citrate lyase	Homo sapiens	0-17
22657152-1	2012	ATP citrate lyase (ACL) catalyzes an ATP-dependent biosynthetic reaction which produces acetyl-coenzyme A and oxaloacetate from citrate and coenzyme A (CoA).	Oxaloacetic Acid	110-122	ATP citrate lyase	Homo sapiens	19-22
21688263-1	2012	ATP citrate lyase (ACL) catalyzes the conversion of cytosolic citrate to acetyl-CoA and oxaloacetate.	Oxaloacetic Acid	88-100	ATP citrate lyase	Homo sapiens	0-17
21688263-1	2012	ATP citrate lyase (ACL) catalyzes the conversion of cytosolic citrate to acetyl-CoA and oxaloacetate.	Oxaloacetic Acid	88-100	ATP citrate lyase	Homo sapiens	19-22
21901531-11	2011	In addition, in cells incubated at low glucose and no glutamine conditions, oxaloacetate and pyruvate reduced AAI-induced apoptosis our data suggest that AAI-GDH interactions in TEC are critical for the induction of apoptosis by direct inhibition of GDH activity.	Oxaloacetic Acid	76-88	glutamate dehydrogenase 1	Homo sapiens	158-161
21901531-11	2011	In addition, in cells incubated at low glucose and no glutamine conditions, oxaloacetate and pyruvate reduced AAI-induced apoptosis our data suggest that AAI-GDH interactions in TEC are critical for the induction of apoptosis by direct inhibition of GDH activity.	Oxaloacetic Acid	76-88	glutamate dehydrogenase 1	Homo sapiens	250-253
22506410-1	2011	Phosphoenolpyruvate carboxylase (PEPC, EC 4.1.1.31) is an important ubiquitous cytosol enzyme that fixes HCO3 together with phosphoenolpyruvate (PEP) and yields oxaloacetate that can be converted to intermediates of the citric acid cycle.	Oxaloacetic Acid	161-173	phosphoenolpyruvate carboxykinase 1	Homo sapiens	0-31
22506410-1	2011	Phosphoenolpyruvate carboxylase (PEPC, EC 4.1.1.31) is an important ubiquitous cytosol enzyme that fixes HCO3 together with phosphoenolpyruvate (PEP) and yields oxaloacetate that can be converted to intermediates of the citric acid cycle.	Oxaloacetic Acid	161-173	phosphoenolpyruvate carboxykinase 1	Homo sapiens	33-37
21889589-8	2011	Optimal inhibition of IDH2(wt/R140Q) activity was obtained with oxaloacetate, which competitively inhibited IDH2(wt/R140Q) activity.	Oxaloacetic Acid	64-76	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	22-26
21958016-1	2011	Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues.	Oxaloacetic Acid	83-95	pyruvate carboxylase	Homo sapiens	0-20
21889589-8	2011	Optimal inhibition of IDH2(wt/R140Q) activity was obtained with oxaloacetate, which competitively inhibited IDH2(wt/R140Q) activity.	Oxaloacetic Acid	64-76	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	108-112
21700028-1	2011	Pyruvate carboxylase (PC) is a critical enzyme in supplying carbon for gluconeogenesis and oxaloacetate for the tricarboxylic acid cycle.	Oxaloacetic Acid	91-103	pyruvate carboxylase	Bos taurus	0-20
21934355-2	2011	The first, pyruvate carboxylase (PC) replenishes oxaloacetate withdrawn from the tricarboxylic acid (TCA) cycle via the carboxylation of pyruvate to form oxaloacetate.	Oxaloacetic Acid	49-61	pyruvate carboxylase	Homo sapiens	11-31
21934355-2	2011	The first, pyruvate carboxylase (PC) replenishes oxaloacetate withdrawn from the tricarboxylic acid (TCA) cycle via the carboxylation of pyruvate to form oxaloacetate.	Oxaloacetic Acid	154-166	pyruvate carboxylase	Homo sapiens	11-31
21700028-1	2011	Pyruvate carboxylase (PC) is a critical enzyme in supplying carbon for gluconeogenesis and oxaloacetate for the tricarboxylic acid cycle.	Oxaloacetic Acid	91-103	pyruvate carboxylase	Bos taurus	22-24
20876337-5	2010	The slow-growing mmdh1mmdh2 mutant has elevated leaf respiration rate in the dark and light, without loss of photosynthetic capacity, suggesting that mMDH normally uses NADH to reduce oxaloacetate to malate, which is then exported to the cytosol, rather than to drive mitochondrial respiration.	Oxaloacetic Acid	184-196	Lactate/malate dehydrogenase family protein	Arabidopsis thaliana	17-27
21058708-2	2010	Aspartate aminotransferase (AAT) is a prototypical PLP-dependent enzyme that catalyzes the reversible interconversion of aspartate and alpha-ketoglutarate with oxalacetate and glutamate.	Oxaloacetic Acid	160-171	pyridoxal phosphatase	Homo sapiens	51-54
20807508-1	2010	Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyses the carboxylation of pyruvate to oxaloacetate thereby allowing supplementation of citric acid cycle intermediates.	Oxaloacetic Acid	100-112	pyruvate carboxylase	Homo sapiens	0-20
20807508-1	2010	Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyses the carboxylation of pyruvate to oxaloacetate thereby allowing supplementation of citric acid cycle intermediates.	Oxaloacetic Acid	100-112	pyruvate carboxylase	Homo sapiens	22-24
21524275-1	2011	PEPC [PEP (phosphoenolpyruvate) carboxylase] is a tightly controlled enzyme located at the core of plant C-metabolism that catalyses the irreversible beta-carboxylation of PEP to form oxaloacetate and Pi.	Oxaloacetic Acid	184-196	phosphoenolpyruvate carboxykinase 1	Homo sapiens	0-4
21185899-9	2011	SE-induced neuronal loss in CA1 was completely prevented in rats treated with pyruvate plus oxaloacetate.	Oxaloacetic Acid	92-104	carbonic anhydrase 1	Rattus norvegicus	28-31
21185899-10	2011	The SE-induced caspase-1 activation was significantly reduced when rats were treated with oxaloacetate or pyruvate plus oxaloacetate.	Oxaloacetic Acid	90-102	caspase 1	Rattus norvegicus	15-24
21185899-10	2011	The SE-induced caspase-1 activation was significantly reduced when rats were treated with oxaloacetate or pyruvate plus oxaloacetate.	Oxaloacetic Acid	120-132	caspase 1	Rattus norvegicus	15-24
20876337-5	2010	The slow-growing mmdh1mmdh2 mutant has elevated leaf respiration rate in the dark and light, without loss of photosynthetic capacity, suggesting that mMDH normally uses NADH to reduce oxaloacetate to malate, which is then exported to the cytosol, rather than to drive mitochondrial respiration.	Oxaloacetic Acid	184-196	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	150-154
19135048-0	2009	Oxaloacetate restores the long-term potentiation impaired in rat hippocampus CA1 region by 2-vessel occlusion.	Oxaloacetic Acid	0-12	carbonic anhydrase 1	Rattus norvegicus	77-80
20026031-6	2010	Citrate/oxaloacetate appearance outside mitochondria also occurred as result of PEP addition to PLM.	Oxaloacetic Acid	8-20	Sodium/potassium-transporting ATPase subunit FXYD1	Sus scrofa	96-99
19795928-6	2009	Propyl gallate, 1,8-naphthalenediol, 2,3-naphthalenediol, ascorbic acid, glutathione, and oxaloacetate protected CS from AAPH-mediated inactivation, with IC(50) values of 9, 14, 34, 37, 150, and 160 muM, respectively.	Oxaloacetic Acid	90-102	citrate synthase	Homo sapiens	113-115
19798673-8	2009	Phosphoenolpyruvate (PEP) carboxykinase was present under all three growth conditions, whereas PEP carboxylase was not detectable, supporting earlier findings that PEP carboxykinase is alone responsible for the anaplerotic production of oxaloacetate from PEP.	Oxaloacetic Acid	237-249	H16_RS18535	Ralstonia eutropha H16	0-39
19798673-8	2009	Phosphoenolpyruvate (PEP) carboxykinase was present under all three growth conditions, whereas PEP carboxylase was not detectable, supporting earlier findings that PEP carboxykinase is alone responsible for the anaplerotic production of oxaloacetate from PEP.	Oxaloacetic Acid	237-249	H16_RS18535	Ralstonia eutropha H16	164-181
19631611-3	2009	Furthermore, metabolites such as arginine, glutamate, citrate, and oxalacetate also exerted a negative effect on the PII-NAGK complex formation in the presence of Mg-ATP.	Oxaloacetic Acid	67-78	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	121-125
19497429-9	2009	At the high F group, pyruvate carboxylase, a protein involved in the formation of oxaloacetate was found to be downregulated, while enoyl coenzyme A hydratase, involved in fatty acids oxidation, was found to be upregulated.	Oxaloacetic Acid	82-94	pyruvate carboxylase	Rattus norvegicus	21-41
19244229-9	2009	In the YscM1(-) and YscM2(-) mutants, increased rates of pyruvate formation via glycolysis or the Entner-Doudoroff pathway, of oxaloacetate formation via the citrate cycle, and of amino acid biosynthesis suggest that both regulators trigger the central metabolism of Y. enterocolitica.	Oxaloacetic Acid	127-139	yscM1	Yersinia enterocolitica	7-12
19244229-9	2009	In the YscM1(-) and YscM2(-) mutants, increased rates of pyruvate formation via glycolysis or the Entner-Doudoroff pathway, of oxaloacetate formation via the citrate cycle, and of amino acid biosynthesis suggest that both regulators trigger the central metabolism of Y. enterocolitica.	Oxaloacetic Acid	127-139	yscM2	Yersinia enterocolitica	20-25
20598931-1	2010	Pyruvate carboxylase (PC) is a regulated mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, a critical transition that replenishes citric acid cycle intermediates and facilitates other biosynthetic reactions that drive anabolism.	Oxaloacetic Acid	107-119	pyruvate carboxylase	Homo sapiens	0-20
20598931-1	2010	Pyruvate carboxylase (PC) is a regulated mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, a critical transition that replenishes citric acid cycle intermediates and facilitates other biosynthetic reactions that drive anabolism.	Oxaloacetic Acid	107-119	pyruvate carboxylase	Homo sapiens	22-24
20664702-7	2010	Malate dehydrogenase catalyzes the interconversion of L-malate and oxaloacetate using NADP as a coenzyme, quantified by its absorbance at 340 nm.	Oxaloacetic Acid	67-79	malic enzyme 1	Homo sapiens	0-20
20371607-6	2010	Reconstituted Yhm2p also transported oxaloacetate, succinate, and fumarate to a lesser extent, but virtually not malate and isocitrate.	Oxaloacetic Acid	37-49	Yhm2p	Saccharomyces cerevisiae S288C	14-19
19896555-11	2010	The anaplerotic conversion of pyruvate to oxaloacetate by pyruvate carboxylase accounted for 10% of the pyruvate flux with the remaining 90% entering the TCA cycle through acetyl-CoA.	Oxaloacetic Acid	42-54	pyruvate carboxylase, mitochondrial	Cricetulus griseus	58-78
18686030-2	2009	PC-catalyzed carboxylation of pyruvate to oxaloacetate is a major anaplerotic reaction in brain.	Oxaloacetic Acid	42-54	pyruvate carboxylase	Homo sapiens	0-2
19035664-3	2009	The decrease in oxaloacetic acid was coupled to NADH formation by malate dehydrogenase, which allowed the rates of both initial carbinolamine formation (as part of the imination step) and decarboxylation to be determined.	Oxaloacetic Acid	16-32	malic enzyme 1	Homo sapiens	66-86
18771573-7	2008	Expression of phosphoenolpyruvate carboxykinase (PEPCK), which catalyses the decarboxylation of oxaloacetate, is decreased in response to increasing intracellular pH.	Oxaloacetic Acid	96-108	phosphoenolpyruvate carboxykinase 1	Arabidopsis thaliana	14-47
18771573-7	2008	Expression of phosphoenolpyruvate carboxykinase (PEPCK), which catalyses the decarboxylation of oxaloacetate, is decreased in response to increasing intracellular pH.	Oxaloacetic Acid	96-108	phosphoenolpyruvate carboxykinase 1	Arabidopsis thaliana	49-54
18682385-2	2008	Recombinant and reconstituted mitochondrial oxalacetate carrier (Oac1p) efficiently transported alpha-IPM in addition to its known substrates oxalacetate, sulfate, and malonate and in contrast to other di- and tricarboxylate transporters as well as the previously proposed alpha-IPM transporter.	Oxaloacetic Acid	44-55	Oac1p	Saccharomyces cerevisiae S288C	65-70
18655006-4	2008	PEPCK activity was determined based on the [H(14)CO(3) (-)]-oxaloacetate exchange reaction.	Oxaloacetic Acid	60-72	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-5
18682385-2	2008	Recombinant and reconstituted mitochondrial oxalacetate carrier (Oac1p) efficiently transported alpha-IPM in addition to its known substrates oxalacetate, sulfate, and malonate and in contrast to other di- and tricarboxylate transporters as well as the previously proposed alpha-IPM transporter.	Oxaloacetic Acid	142-153	Oac1p	Saccharomyces cerevisiae S288C	65-70
18682385-9	2008	Oac1p is important for leucine biosynthesis on fermentable carbon sources catalyzing the export of alpha-IPM, probably in exchange for oxalacetate.	Oxaloacetic Acid	135-146	Oac1p	Saccharomyces cerevisiae S288C	0-5
17685635-0	2007	Structures of rat cytosolic PEPCK: insight into the mechanism of phosphorylation and decarboxylation of oxaloacetic acid.	Oxaloacetic Acid	104-120	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	28-33
18613815-1	2008	PC (pyruvate carboxylase) is a biotin-containing enzyme that catalyses the HCO(3)(-)- and MgATP-dependent carboxylation of pyruvate to form oxaloacetate.	Oxaloacetic Acid	140-152	pyruvate carboxylase	Homo sapiens	0-2
18613815-1	2008	PC (pyruvate carboxylase) is a biotin-containing enzyme that catalyses the HCO(3)(-)- and MgATP-dependent carboxylation of pyruvate to form oxaloacetate.	Oxaloacetic Acid	140-152	pyruvate carboxylase	Homo sapiens	4-24
18039180-3	2008	DIC1-DIC3 have been reported previously as uncoupling proteins, but direct transport assays with recombinant and reconstituted DIC proteins clearly demonstrate that their substrate specificity is unique to plants, showing the combined characteristics of the DIC and oxaloacetate carrier in yeast.	Oxaloacetic Acid	266-278	Dic1p	Saccharomyces cerevisiae S288C	0-4
18297087-1	2008	Pyruvate carboxylase (PC) catalyzes the biotin-dependent production of oxaloacetate and has important roles in gluconeogenesis, lipogenesis, insulin secretion and other cellular processes.	Oxaloacetic Acid	71-83	pyruvate carboxylase	Homo sapiens	0-20
20641814-4	2004	Another major pathway is the conversion of Pyr into oxaloacetate by PDH.	Oxaloacetic Acid	52-64	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	68-71
17603759-7	2007	Purified mMDH catalysed the reduction of alpha-ketoglutarate to L-2-hydroxyglutarate with a catalytic efficiency that was about 10(7)-fold lower than that observed with oxaloacetate.	Oxaloacetic Acid	169-181	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	9-13
18922930-2	2008	ATP citrate lyase (ACLY) is a key enzyme of de novo fatty acid synthesis responsible for generating cytosolic acetyl-CoA and oxaloacetate.	Oxaloacetic Acid	125-137	ATP citrate lyase	Homo sapiens	0-17
18922930-2	2008	ATP citrate lyase (ACLY) is a key enzyme of de novo fatty acid synthesis responsible for generating cytosolic acetyl-CoA and oxaloacetate.	Oxaloacetic Acid	125-137	ATP citrate lyase	Homo sapiens	19-23
18403382-7	2008	By measuring the capacity of the mitochondrial shuttle, it was found that the OAA produced via mMDH seemed not to be transported outside the mitochondria, but mAST interconverted OAA and Glu to Asp and alpha-KG, respectively, and exported them out via a malate-aspartate (malate-Asp) shuttle.	Oxaloacetic Acid	78-81	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	95-99
17623847-0	2007	Substrate polarization in enzyme catalysis: QM/MM analysis of the effect of oxaloacetate polarization on acetyl-CoA enolization in citrate synthase.	Oxaloacetic Acid	76-88	citrate synthase	Sus scrofa	131-147
17823126-8	2007	Ad-siCL3-treated cells also exhibited a 52 +/- 7% reduction in cytosolic oxaloacetate, an 83 +/- 4% reduction in malonyl-CoA levels, and inhibition of [U-(14)C]glucose incorporation into lipid by 43 +/- 4%, all expected metabolic out-comes of CL suppression.	Oxaloacetic Acid	73-85	ATP citrate lyase	Rattus norvegicus	5-7
17685635-6	2007	In the PEPCK-Mn2+-GTP structure, the same water molecule displaced by the C1 carboxylate of OAA is displaced by one of the gamma-phosphate oxygens of the triphosphate nucleotide.	Oxaloacetic Acid	92-95	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	7-12
17182618-4	2007	Oxaloacetate was an additional inhibitor of all three HIF-P4Hs with K(i) values of 400-1000 microM and citrate of HIF-P4H-3, citrate being the most effective inhibitor of FIH with a K(i) of 110 microM.	Oxaloacetic Acid	0-12	egl-9 family hypoxia inducible factor 3	Homo sapiens	114-123
16270328-3	2005	In this paper, we report, for the first time, the in vivo carbon magnetization transfer (CMT) effect and in vivo detection of the CMT effects of the alpha-ketoglutarate <--> glutamate and the oxaloacetate <--> aspartate reactions, both of which are catalyzed by aspartate aminotransferase.	Oxaloacetic Acid	198-210	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	274-300
17709878-3	2007	These phenotypes arise from perturbations not only in gluconeogenesis but in two additional metabolic functions of PEPCK-C: (1) cataplerosis which maintains metabolic flux through the Krebs cycle by removing excess oxaloacetate, and (2) glyceroneogenesis which produces glycerol-3-phosphate as a precursor for fatty acid esterification into triglycerides.	Oxaloacetic Acid	215-227	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	115-122
17709878-4	2007	PEPCK-C catalyzes the conversion of oxaloacetate + GTP to phosphoenolpyruvate + GDP + CO2.	Oxaloacetic Acid	36-48	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	0-7
16691317-1	2006	Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes guanosine or adenosine mononucleotide-dependent reversible conversion of oxaloacetate (OAA) and phosphoenolpyruvate (PEP).	Oxaloacetic Acid	125-137	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	0-33
16691317-1	2006	Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes guanosine or adenosine mononucleotide-dependent reversible conversion of oxaloacetate (OAA) and phosphoenolpyruvate (PEP).	Oxaloacetic Acid	125-137	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	35-40
16691317-1	2006	Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes guanosine or adenosine mononucleotide-dependent reversible conversion of oxaloacetate (OAA) and phosphoenolpyruvate (PEP).	Oxaloacetic Acid	139-142	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	0-33
16691317-1	2006	Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes guanosine or adenosine mononucleotide-dependent reversible conversion of oxaloacetate (OAA) and phosphoenolpyruvate (PEP).	Oxaloacetic Acid	139-142	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	35-40
16819824-1	2006	Phosphoenolpyruvate carboxykinase catalyzes the reversible decarboxylation of oxaloacetic acid with the concomitant transfer of the gamma-phosphate of GTP to form PEP and GDP as the first committed step of gluconeogenesis and glyceroneogenesis.	Oxaloacetic Acid	78-94	progestagen associated endometrial protein	Homo sapiens	163-166
16733230-7	2006	Blocking the increase of insulin in the LPR with exogenous pyruvate or oxaloacetate blocked insulin"s stimulation and insulin"s plus Ang II"s synergistic stimulation of O(2)(-)production as well as insulin"s stimulation of migration of Ang II-treated VSMC.	Oxaloacetic Acid	71-83	angiogenin	Rattus norvegicus	133-136
16505973-1	2006	Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate.	Oxaloacetic Acid	83-95	pyruvate carboxylase	Homo sapiens	0-20
16505973-1	2006	Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate.	Oxaloacetic Acid	83-95	pyruvate carboxylase	Homo sapiens	22-24
16505973-3	2006	In liver and kidney, PC provides oxaloacetate for gluconeogenesis.	Oxaloacetic Acid	33-45	pyruvate carboxylase	Homo sapiens	21-23
16223732-4	2005	Here we show that the glucose metabolites pyruvate and oxaloacetate inactivate HIF-1alpha decay in a manner selectively reversible by ascorbate, cysteine, histidine, and ferrous iron but not by 2-oxoglutarate or oxygen.	Oxaloacetic Acid	55-67	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-89
16223732-5	2005	Pyruvate and oxaloacetate bind to the 2-oxoglutarate site of HIF-1alpha prolyl hydroxylases, but their effects on HIF-1 are not mimicked by other Krebs cycle intermediates, including succinate and fumarate.	Oxaloacetic Acid	13-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-71
16223732-5	2005	Pyruvate and oxaloacetate bind to the 2-oxoglutarate site of HIF-1alpha prolyl hydroxylases, but their effects on HIF-1 are not mimicked by other Krebs cycle intermediates, including succinate and fumarate.	Oxaloacetic Acid	13-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-66
15967803-11	2005	Our data suggest that by inducing PDK genes PGC-1alpha will direct pyruvate away from metabolism into acetyl-CoA and toward the formation of oxaloacetate and into the gluconeogenic pathway.	Oxaloacetic Acid	141-153	PPARG coactivator 1 alpha	Rattus norvegicus	44-54
16154636-2	2005	Malate dehydrogenase (MDH) was utilized as a coupling enzyme to detect either malate or oxaloacetate in the presence of their respective substrates and cofactors.	Oxaloacetic Acid	88-100	malic enzyme 1	Homo sapiens	0-20
16154636-2	2005	Malate dehydrogenase (MDH) was utilized as a coupling enzyme to detect either malate or oxaloacetate in the presence of their respective substrates and cofactors.	Oxaloacetic Acid	88-100	malic enzyme 1	Homo sapiens	22-25
15507531-6	2005	The latter is an indicator of pyruvate-malate cycle activity, indicating that most of the increased pyruvate was converted to oxaloacetate (OAA) through the PC pathway.	Oxaloacetic Acid	126-138	pyruvate carboxylase	Rattus norvegicus	157-159
15888376-4	2005	As a result, oxaloacetate is consumed and is less available to the aspartate aminotransferase reaction; therefore, less glutamate is converted to aspartate and relatively more glutamate becomes available to the glutamine synthetase and glutamate decarboxylase reactions.	Oxaloacetic Acid	13-25	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	211-231
15888376-4	2005	As a result, oxaloacetate is consumed and is less available to the aspartate aminotransferase reaction; therefore, less glutamate is converted to aspartate and relatively more glutamate becomes available to the glutamine synthetase and glutamate decarboxylase reactions.	Oxaloacetic Acid	13-25	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	236-259
15507531-6	2005	The latter is an indicator of pyruvate-malate cycle activity, indicating that most of the increased pyruvate was converted to oxaloacetate (OAA) through the PC pathway.	Oxaloacetic Acid	140-143	pyruvate carboxylase	Rattus norvegicus	157-159
15730627-17	2004	The number of pits on OAAS after addition of AA + RANKL was significantly lower than that after addition of RANKL alone (P < 0.05).	Oxaloacetic Acid	22-26	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	50-55
15695345-8	2005	Sequential addition of phosphoenolpyruvate and oxaloacetate to the assay facilitated identification of 83 extracts that specifically inhibited PPDK.	Oxaloacetic Acid	47-59	pyruvate, phosphate dikinase 1, chloroplastic	Zea mays	143-147
15234082-5	2004	The primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis.	Oxaloacetic Acid	203-215	ATP citrate lyase	Homo sapiens	124-141
15245332-3	2004	Kinetic characterization and oxaloacetate partition ratio of the NADP(+)-ME K255I (Lys-255-->Ile) mutant suggest that the mutated lysine residue is implicated in catalysis and substrate binding.	Oxaloacetic Acid	29-41	NADP-dependent malic enzyme	Zea mays	65-75
14984367-10	2004	Pyruvate and oxaloacetate treatment of cells also up-regulates HPH-1 and HPH-2, but not HPH-3 or the HIF asparaginyl hydroxylase FIH-1 (factor inhibiting HIF).	Oxaloacetic Acid	13-25	egl-9 family hypoxia inducible factor 2	Homo sapiens	63-68
15388227-0	2004	Characterization of a cytosolic malate dehydrogenase cDNA which encodes an isozyme toward oxaloacetate reduction in wheat.	Oxaloacetic Acid	90-102	malate dehydrogenase, cytoplasmic	Triticum aestivum	22-52
14984367-10	2004	Pyruvate and oxaloacetate treatment of cells also up-regulates HPH-1 and HPH-2, but not HPH-3 or the HIF asparaginyl hydroxylase FIH-1 (factor inhibiting HIF).	Oxaloacetic Acid	13-25	egl-9 family hypoxia inducible factor 1	Homo sapiens	73-78
12855734-1	2003	Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) to form phosphoenolpyruvate (PEP).	Oxaloacetic Acid	106-118	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	0-33
15228099-2	2004	HCA is a competitive inhibitor of the enzyme ATP citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl CoA) in the cytosol.	Oxaloacetic Acid	124-136	ATP citrate lyase	Rattus norvegicus	45-62
14988489-7	2004	In particular, ZmpOMT1 transported oxaloacetate at a higher efficiency than malate or 2-oxoglutarate.	Oxaloacetic Acid	35-47	Dicarboxylate transporter 1, chloroplastic	Zea mays	15-22
14988489-9	2004	The K(m) value for oxaloacetate in MC chloroplasts was one order of magnitude lower than that in BSC chloroplasts, and was close to that determined with the recombinant ZmpOMT1 protein.	Oxaloacetic Acid	19-31	Dicarboxylate transporter 1, chloroplastic	Zea mays	169-176
14988489-11	2004	These findings suggest that ZmpOMT1 participates in the import of oxaloacetate into MC chloroplasts in exchange for stromal malate.	Oxaloacetic Acid	66-78	Dicarboxylate transporter 1, chloroplastic	Zea mays	28-35
12855734-1	2003	Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) to form phosphoenolpyruvate (PEP).	Oxaloacetic Acid	106-118	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	35-40
12855734-1	2003	Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) to form phosphoenolpyruvate (PEP).	Oxaloacetic Acid	120-123	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	0-33
12855734-1	2003	Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the reversible decarboxylation and phosphorylation of oxaloacetate (OAA) to form phosphoenolpyruvate (PEP).	Oxaloacetic Acid	120-123	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	35-40
12781768-1	2003	Phosphoenolpyruvate carboxylase (PEPC; EC 4.1.1.31) catalyzes the irreversible carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate and Pi using Mg2+ or Mn2+ as a cofactor.	Oxaloacetic Acid	130-142	MLO-like protein 4	Zea mays	0-31
12781768-1	2003	Phosphoenolpyruvate carboxylase (PEPC; EC 4.1.1.31) catalyzes the irreversible carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate and Pi using Mg2+ or Mn2+ as a cofactor.	Oxaloacetic Acid	130-142	MLO-like protein 4	Zea mays	33-37
12781768-1	2003	Phosphoenolpyruvate carboxylase (PEPC; EC 4.1.1.31) catalyzes the irreversible carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate and Pi using Mg2+ or Mn2+ as a cofactor.	Oxaloacetic Acid	130-142	phosphoenolpyruvate carboxylase 2	Zea mays	33-36
12692343-1	2003	Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the gluconeogenic production of sugars from storage oil in germinating oilseeds.	Oxaloacetic Acid	70-82	phosphoenolpyruvate carboxykinase 1	Arabidopsis thaliana	0-33
12692343-1	2003	Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the gluconeogenic production of sugars from storage oil in germinating oilseeds.	Oxaloacetic Acid	70-82	phosphoenolpyruvate carboxykinase 1	Arabidopsis thaliana	35-40
21669645-4	2001	An active malate dehydrogenase is required to facilitate carbon flow from phosphoenolpyruvate to oxaloacetate.	Oxaloacetic Acid	97-109	malate dehydrogenase	Glycine max	10-30
12598567-1	2003	Phosphoenolpyruvate carboxylase (PEPC), which catalyses the carboxylation of phosphoenolpyruvate using HCO(3)(-) to generate oxaloacetic acid, is an important enzyme in the primary metabolism of plants.	Oxaloacetic Acid	125-141	phosphoenolpyruvate carboxylase	Nicotiana tabacum	0-31
12598567-1	2003	Phosphoenolpyruvate carboxylase (PEPC), which catalyses the carboxylation of phosphoenolpyruvate using HCO(3)(-) to generate oxaloacetic acid, is an important enzyme in the primary metabolism of plants.	Oxaloacetic Acid	125-141	phosphoenolpyruvate carboxylase	Nicotiana tabacum	33-37
12150961-1	2002	Pyruvate carboxylase (PC) [EC 6.4.1.1] is a biotin-dependent carboxylase that catalyses the conversion of pyruvate to oxaloacetate.	Oxaloacetic Acid	118-130	pyruvate carboxylase	Gallus gallus	0-25
11939620-7	2002	Blocking insulin"s increase in LPR by pyruvate (0.5 mmol/L) or oxaloacetate (0.5 mmol/L) completely inhibited the insulin-stimulated component of cGMP production.	Oxaloacetic Acid	63-75	insulin	Canis lupus familiaris	9-16
11939620-7	2002	Blocking insulin"s increase in LPR by pyruvate (0.5 mmol/L) or oxaloacetate (0.5 mmol/L) completely inhibited the insulin-stimulated component of cGMP production.	Oxaloacetic Acid	63-75	insulin	Canis lupus familiaris	114-121
16228378-3	2003	Compared with untransformed rice, the level of the substrate for PEPC (phosphoenolpyruvate) was slightly lower and the product (oxaloacetate) was slightly higher in transgenic rice, suggesting that maize PEPC was functioning even though it remained dephosphorylated and less active in the light.	Oxaloacetic Acid	128-140	phosphoenolpyruvate carboxylase 1	Zea mays	204-208
12220660-3	2002	In addition, Ae-HKT/AGT is also able to catalyze the transamination of 3-HK or kynurenine with glyoxylate, pyruvate or oxaloacetate as the amino acceptor.	Oxaloacetic Acid	119-131	O-6-alkylguanine-DNA alkyltransferase	Drosophila melanogaster	20-23
12079877-1	2002	Mammals metabolize citrate to acetyl-CoA and oxaloacetate via the enzyme, ATP:citrate lyase.	Oxaloacetic Acid	45-57	ATP citrate lyase	Homo sapiens	74-91
11964223-3	2002	To demonstrate the power of the methodology, simulations have been conducted on an artificial fusion protein of citrate synthase (CS) and malate dehydrogenase (MDH) to assess the chances of oxaloacetate being channeled between the MDH and CS active sites.	Oxaloacetic Acid	190-202	citrate synthase	Homo sapiens	112-128
11964223-3	2002	To demonstrate the power of the methodology, simulations have been conducted on an artificial fusion protein of citrate synthase (CS) and malate dehydrogenase (MDH) to assess the chances of oxaloacetate being channeled between the MDH and CS active sites.	Oxaloacetic Acid	190-202	citrate synthase	Homo sapiens	130-132
21669645-3	2001	Oxaloacetate can be derived from the tricarboxylic acid (TCA) cycle, and it also can be synthesized from phosphoenolpyruvate and carbon dioxide by phosphoenolpyruvate carboxylase.	Oxaloacetic Acid	0-12	phosphoenolpyruvate carboxylase, housekeeping isozyme	Glycine max	147-178
11595217-3	2001	Synthesis was performed by condensation of 2,4-diacetamido-2,4,6-trideoxy-L-gulose, -D-mannose, -D-talose, and -L-allose with oxalacetic acid under basic conditions, the reaction of the last two precursors being accompanied by epimerisation at C-2.	Oxaloacetic Acid	126-141	complement C2	Homo sapiens	244-247
11697863-9	2001	We propose that specific up-regulation of renal PDK4 protein expression in starvation, by maintaining PDC activity relatively low, facilitates pyruvate carboxylation to oxaloacetate and therefore entry of acetyl-CoA derived from FA beta-oxidation into the TCA cycle, allowing adequate ATP production for brisk rates of gluconeogenesis.	Oxaloacetic Acid	169-181	pyruvate dehydrogenase kinase, isoenzyme 4	Mus musculus	48-52
11551200-1	2001	The enzyme phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the reversible conversion of oxalacetate and GTP to phosphoenolpyruvate (PEP), GDP, and CO2.	Oxaloacetic Acid	92-103	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	11-44
11551200-1	2001	The enzyme phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the reversible conversion of oxalacetate and GTP to phosphoenolpyruvate (PEP), GDP, and CO2.	Oxaloacetic Acid	92-103	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	46-51
11083877-10	2001	Adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate were also transported by the human ODC.	Oxaloacetic Acid	85-97	solute carrier family 25 member 21	Homo sapiens	146-149
11389141-1	2001	Malate dehydrogenase specifically oxidizes malate to oxaloacetate.	Oxaloacetic Acid	53-65	malic enzyme 2	Homo sapiens	0-20
11171137-1	2000	ATP citrate lyase (ACL) catalyses the ATP-dependent reaction between citrate and CoA to form oxaloacetate and acetyl-CoA.	Oxaloacetic Acid	93-105	acetone-cyanohydrin lyase	Arabidopsis thaliana	0-17
11171137-1	2000	ATP citrate lyase (ACL) catalyses the ATP-dependent reaction between citrate and CoA to form oxaloacetate and acetyl-CoA.	Oxaloacetic Acid	93-105	acetone-cyanohydrin lyase	Arabidopsis thaliana	19-22
12549038-3	2000	Citrate synthase plays a key role in regulating TCA cycle and is responsible for catalysing the synthesis of citrate from oxaloacetate and acetyl CoA.	Oxaloacetic Acid	122-134	citrate synthase	Homo sapiens	0-16
10759520-1	2000	ATP:citrate lyase (ACL) catalyzes the conversion of citrate to acetyl-coenzyme A (CoA) and oxaloacetate and is a key enzyme for lipid accumulation in mammals and oleaginous yeasts and fungi.	Oxaloacetic Acid	91-103	ATP citrate lyase	Rattus norvegicus	0-17
10759520-1	2000	ATP:citrate lyase (ACL) catalyzes the conversion of citrate to acetyl-coenzyme A (CoA) and oxaloacetate and is a key enzyme for lipid accumulation in mammals and oleaginous yeasts and fungi.	Oxaloacetic Acid	91-103	ATP citrate lyase	Rattus norvegicus	19-22