PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11747431-6	2001	We also show that yeast cofilin can differentiate between various phosphatidylinositides, and mapped the PI(4,5)P2 binding site by using a collection of cofilin mutants.	phosphatidylinositides	66-88	cofilin	Saccharomyces cerevisiae S288C	24-31
10818094-5	2000	The deduced zebrafish gelsolin is approximately 60% identical to mammalian cytosolic gelsolin and has the characteristic six segmental repeats as well as the binding sites for actin, calcium, and phosphatidylinositides.	phosphatidylinositides	196-218	gelsolin a	Danio rerio	22-30
12835095-2	2000	Phospholipase Cgamma (PLCgamma) is an early downstream effector for the Trk receptors, and catalyzes the hydrolysis of phosphatidylinositides (PI) to inositol phosphates (IPs) and diacylglycerol.	phosphatidylinositides	119-141	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	72-75
10799529-4	2000	Production of 3"-phosphorylated phosphatidylinositides (3 phosphoinositides) was also required for ISO-induced ANF transcription.	phosphatidylinositides	32-54	natriuretic peptide A	Homo sapiens	111-114
1537879-5	1992	Thrombin also induced an increase in inositol trisphosphate (IP3), suggesting that phospholipase C activation and phosphatidylinositides breakdown were stimulated.	phosphatidylinositides	114-136	coagulation factor II, thrombin	Homo sapiens	0-8
7994761-5	1994	Lack of cytotoxic function was not due to abrogation of conjugate formation, but was associated with inhibition of both granule exocytosis and phosphatidylinositides turnover, thus indicating that PTK activity is an obligatory event for the activation of antigen-specific CTL effector function.	phosphatidylinositides	143-165	protein tyrosine kinase 2 beta	Homo sapiens	197-200
8268137-4	1993	Cross-linkage of Ig beta on B cells leads to activation of tyrosine kinases, hydrolysis of phosphatidylinositides, and elevation of intracellular Ca2+, effects qualitatively identical to those of anti-mu mAbs.	phosphatidylinositides	91-113	CD79b molecule	Homo sapiens	17-24
10698513-1	2000	The human PTEN/MMAC1/TEP1 (PTEN) tumor suppressor gene encodes a phosphatase with specificity towards the D3 phosphate of phosphatidylinositides.	phosphatidylinositides	122-144	phosphatase and tensin homolog	Homo sapiens	10-14
10698513-1	2000	The human PTEN/MMAC1/TEP1 (PTEN) tumor suppressor gene encodes a phosphatase with specificity towards the D3 phosphate of phosphatidylinositides.	phosphatidylinositides	122-144	phosphatase and tensin homolog	Homo sapiens	15-20
10698513-1	2000	The human PTEN/MMAC1/TEP1 (PTEN) tumor suppressor gene encodes a phosphatase with specificity towards the D3 phosphate of phosphatidylinositides.	phosphatidylinositides	122-144	telomerase associated protein 1	Homo sapiens	21-25
10698513-1	2000	The human PTEN/MMAC1/TEP1 (PTEN) tumor suppressor gene encodes a phosphatase with specificity towards the D3 phosphate of phosphatidylinositides.	phosphatidylinositides	122-144	phosphatase and tensin homolog	Homo sapiens	27-31
9891043-1	1999	Tyrosine kinase receptors lead to rapid activation of phosphatidylinositol 3-kinase (PI3 kinase) and the subsequent formation of phosphatidylinositides (PtdIns) 3,4-P2 and PtdIns 3,4, 5-P3, which are thought to be involved in signaling for glucose transporter GLUT4 translocation, cytoskeletal rearrangement, and DNA synthesis.	phosphatidylinositides	129-151	solute carrier family 2 member 4	Homo sapiens	260-265
9733716-0	1998	Phosphatidylinositides bind to plasma membrane CD14 and can prevent monocyte activation by bacterial lipopolysaccharide.	phosphatidylinositides	0-22	CD14 molecule	Homo sapiens	47-51
9733716-2	1998	We report here that phosphatidylinositol (PtdIns), phosphatidylinositol-4-phosphate, and other phosphatidylinositides can bind to mCD14.	phosphatidylinositides	95-117	CD14 antigen	Mus musculus	130-135
2154685-3	1990	Neomycin, which specifically binds to phosphatidylinositides and inhibits their metabolism, blocked meiotic maturation induced by ras or insulin but not by progesterone or TPA.	phosphatidylinositides	38-60	insulin S homeolog	Xenopus laevis	137-144
2192849-14	1990	An important new insight is provided by the observation that agonists (e.g., CCK or acetylcholine) that act to stimulate the hydrolysis of phosphatidylinositides, when acting for a short period (10-20 min), induce an enhanced responsiveness of islets to glucose, i.e., proemial sensitization.	phosphatidylinositides	139-161	cholecystokinin	Homo sapiens	77-80
1658519-1	1991	The effect of human serum albumin (HSA) on the hydrolysis of phosphatidylinositides in human platelets labeled with myo(3H)inositol was studied.	phosphatidylinositides	61-83	albumin	Homo sapiens	20-33
34846128-3	2021	However, the binding preferences of Kir3.4 for the headgroup and acyl chains of phosphorylated phosphatidylinositides (PIPs) and other lipids are not well understood.	phosphatidylinositides	95-117	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	36-42
28761175-8	2017	This study provides new insights into Rac1 functioning on plasma membrane dynamics combining phosphatidylinositides and cytoskeleton regulation.	phosphatidylinositides	93-115	Rac family small GTPase 1	Homo sapiens	38-42
2555218-1	1989	In response to epidermal growth factor (EGF) and the Ca2+ ionophore A23187, the total phosphatidylinositides (IPT) increased in A431 human epidermoid carcinoma cells 1.8- and 2.0-fold and in the EGF-dependent A431/Clone 15-2 cells 3.0- and 8.0-fold, respectively, over basal levels.	phosphatidylinositides	86-108	epidermal growth factor	Homo sapiens	15-38
2555218-1	1989	In response to epidermal growth factor (EGF) and the Ca2+ ionophore A23187, the total phosphatidylinositides (IPT) increased in A431 human epidermoid carcinoma cells 1.8- and 2.0-fold and in the EGF-dependent A431/Clone 15-2 cells 3.0- and 8.0-fold, respectively, over basal levels.	phosphatidylinositides	86-108	epidermal growth factor	Homo sapiens	40-43
2555218-1	1989	In response to epidermal growth factor (EGF) and the Ca2+ ionophore A23187, the total phosphatidylinositides (IPT) increased in A431 human epidermoid carcinoma cells 1.8- and 2.0-fold and in the EGF-dependent A431/Clone 15-2 cells 3.0- and 8.0-fold, respectively, over basal levels.	phosphatidylinositides	86-108	tRNA isopentenyltransferase 1	Homo sapiens	110-113
2555218-1	1989	In response to epidermal growth factor (EGF) and the Ca2+ ionophore A23187, the total phosphatidylinositides (IPT) increased in A431 human epidermoid carcinoma cells 1.8- and 2.0-fold and in the EGF-dependent A431/Clone 15-2 cells 3.0- and 8.0-fold, respectively, over basal levels.	phosphatidylinositides	86-108	epidermal growth factor	Homo sapiens	195-198
32416313-12	2020	CONCLUSION: Our data indicate that STARD10 binds to, and may transport, phosphatidylinositides, influencing membrane lipid composition, insulin granule biosynthesis and insulin processing.	phosphatidylinositides	72-94	START domain containing 10	Mus musculus	35-42
29323279-3	2018	This structure reveals that econazole resides in a hydrophobic pocket analogous to that occupied by phosphatidylinositides and vanilloids in TRPV1, thus suggesting conserved mechanisms for ligand recognition and lipid binding among TRPV channels.	phosphatidylinositides	100-122	transient receptor potential cation channel subfamily V member 1	Oryctolagus cuniculus	141-146
33627135-8	2021	The Amyloid-beta deposits and extracellular Tau seeds disrupt phosphatidylinositides level and actin cytoskeletal network that hamper microglial-signaling pathways in AD.	phosphatidylinositides	62-84	amyloid beta precursor protein	Homo sapiens	4-16
33627135-8	2021	The Amyloid-beta deposits and extracellular Tau seeds disrupt phosphatidylinositides level and actin cytoskeletal network that hamper microglial-signaling pathways in AD.	phosphatidylinositides	62-84	microtubule associated protein tau	Homo sapiens	44-47
32372643-0	2020	Insight into the selectivity of Kir3.2 toward phosphatidylinositides.	phosphatidylinositides	46-68	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	32-38
25597631-4	2015	Lipidomic analysis of annexin A2-deficient mouse cells indicates that this protein plays a role in recruiting phosphatidylserine and phosphatidylinositides to Atg16L-positive vesicles.	phosphatidylinositides	133-155	annexin A2	Mus musculus	22-32
25597631-4	2015	Lipidomic analysis of annexin A2-deficient mouse cells indicates that this protein plays a role in recruiting phosphatidylserine and phosphatidylinositides to Atg16L-positive vesicles.	phosphatidylinositides	133-155	autophagy related 16-like 1 (S. cerevisiae)	Mus musculus	159-165
23658066-3	2013	Here, we describe an even more salt-sensitive 5ptase mutant, At5ptase9, which also hydrolyzes the 5" phosphate groups specifically from membrane-bound phosphatidylinositides.	phosphatidylinositides	151-173	inositol polyphosphate-5-phosphatase B	Homo sapiens	46-52
21329509-2	2011	The Kalrn gene encodes several functionally distinct isoforms; these multidomain guanine nucleotide exchange factors (GEFs) contain additional domains known to interact with phosphatidylinositides as well as with a number of different proteins.	phosphatidylinositides	174-196	kalirin, RhoGEF kinase	Mus musculus	4-9
19109164-6	2009	Thus, Btk regulates actin dynamics and Ag transport by activating Wiskott-Aldrich syndrome protein via Vav and phosphatidylinositides.	phosphatidylinositides	111-133	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	6-9
15567406-4	2005	PTB domains bind both peptides and headgroups of phosphatidylinositides, utilizing two distinct binding motifs to mediate spatial organization and localization within cells.	phosphatidylinositides	49-71	polypyrimidine tract binding protein 1	Homo sapiens	0-3
17580960-2	2007	Therefore, the interaction between caveolin-1 and sterol carrier protein-2 (SCP-2), a protein that binds and transfers both cholesterol and signaling lipids (e.g., phosphatidylinositides and sphingolipids), was examined by yeast two-hybrid, in vitro binding and fluorescence resonance energy transfer (FRET) analyses.	phosphatidylinositides	164-186	caveolin 1	Homo sapiens	35-45
17580960-2	2007	Therefore, the interaction between caveolin-1 and sterol carrier protein-2 (SCP-2), a protein that binds and transfers both cholesterol and signaling lipids (e.g., phosphatidylinositides and sphingolipids), was examined by yeast two-hybrid, in vitro binding and fluorescence resonance energy transfer (FRET) analyses.	phosphatidylinositides	164-186	sterol carrier protein 2	Homo sapiens	50-74
17580960-2	2007	Therefore, the interaction between caveolin-1 and sterol carrier protein-2 (SCP-2), a protein that binds and transfers both cholesterol and signaling lipids (e.g., phosphatidylinositides and sphingolipids), was examined by yeast two-hybrid, in vitro binding and fluorescence resonance energy transfer (FRET) analyses.	phosphatidylinositides	164-186	sterol carrier protein 2	Homo sapiens	76-81
17057714-1	2006	ESCRT-II, a complex that sorts ubiquitinated membrane proteins to lysosomes, localizes to endosomes through interaction between the Vps36 subunit"s GLUE domain and phosphatidylinositides (PIs).	phosphatidylinositides	164-186	vacuolar protein sorting 36 homolog	Homo sapiens	132-137
15843031-3	2005	We now show the hSH3 domain of ADAP to be a lipid-interaction module that binds to acidic lipids, including phosphatidylinositides.	phosphatidylinositides	108-130	FYN binding protein	Mus musculus	31-35
17609102-3	2007	(2007) report that SNX9, a protein that binds phosphatidylinositides, dynamin, and N-WASP, coordinates actin assembly with several distinct endocytic processes.	phosphatidylinositides	46-68	sorting nexin 9	Homo sapiens	19-23
15581351-0	2004	Structural perturbations in human ADP ribosylation factor-1 accompanying the binding of phosphatidylinositides.	phosphatidylinositides	88-110	ADP ribosylation factor 1	Homo sapiens	34-59
15581351-7	2004	The identified binding site and the resultant structural changes are discussed in terms of a possible influence of phosphatidylinositides on the binding of Arf1 to Arf1-GEF and subsequent nucleotide release.	phosphatidylinositides	115-137	ADP ribosylation factor 1	Homo sapiens	156-160
15581351-7	2004	The identified binding site and the resultant structural changes are discussed in terms of a possible influence of phosphatidylinositides on the binding of Arf1 to Arf1-GEF and subsequent nucleotide release.	phosphatidylinositides	115-137	golgi brefeldin A resistant guanine nucleotide exchange factor 1	Homo sapiens	164-172
15140579-6	2004	Tollip binding with 3"-phosphorylated phosphatidylinositides implies that PI3 kinase may regulate its function.	phosphatidylinositides	38-60	toll interacting protein	Homo sapiens	0-6
15313562-0	2004	Assays of RGS protein modulation by phosphatidylinositides and calmodulin.	phosphatidylinositides	36-58	paired like homeodomain 2	Homo sapiens	10-13
12972602-4	2003	We show that the UNC-73B PH domain binds preferentially to monophosphorylated phosphatidylinositides in vitro.	phosphatidylinositides	78-100	Uncharacterized protein	Caenorhabditis elegans	17-23