PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23231395-8	2012	MAO-A is a target of an endogenous neurotoxin, Nmethyl( R)salsolinol, and MAO-A knockdown (KO) with short interfering (si)RNA protects neuronal death from apoptosis.	salsoline	47-68	monoamine oxidase A	Homo sapiens	0-5
24252728-0	2014	TRPC1 protects dopaminergic SH-SY5Y cells from MPP+, salsolinol, and N-methyl-(R)-salsolinol-induced cytotoxicity.	salsoline	69-92	transient receptor potential cation channel subfamily C member 1	Homo sapiens	0-5
24252728-3	2014	In the present study, N-methyl-(R)-salsolinol was tested for its cellular toxicity and effects on TRPC1 expression.	salsoline	22-45	transient receptor potential cation channel subfamily C member 1	Homo sapiens	98-103
22946763-7	2012	The designed AChE biosensor was successfully applied to evaluate the AChE inhibition induced by endogenous neurotoxin 1(R),2N-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [(R)-NMSal].	salsoline	118-179	acetylcholinesterase (Cartwright blood group)	Homo sapiens	13-17
22946763-7	2012	The designed AChE biosensor was successfully applied to evaluate the AChE inhibition induced by endogenous neurotoxin 1(R),2N-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [(R)-NMSal].	salsoline	118-179	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-73
15035819-3	2003	This paper describes the activities of propargylamine MAO-B inhibitors against apoptosis induced by an endogenous selective dopaminergic neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells.	salsoline	149-170	monoamine oxidase B	Homo sapiens	54-59
15843867-0	2006	N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2.	salsoline	92-113	BCL2 apoptosis regulator	Homo sapiens	195-200
16336631-3	2006	An endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, an MAO-A inhibitor, reduced membrane potential, DeltaPsim, in isolated mitochondria, and induced apoptosis in the cells, which 5-hydroxytryptamine, an MAO-A substrate, prevented.	salsoline	39-60	monoamine oxidase A	Homo sapiens	65-70
16336631-3	2006	An endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, an MAO-A inhibitor, reduced membrane potential, DeltaPsim, in isolated mitochondria, and induced apoptosis in the cells, which 5-hydroxytryptamine, an MAO-A substrate, prevented.	salsoline	39-60	monoamine oxidase A	Homo sapiens	213-218
16336631-6	2006	RNA interference targeting MAO-A significantly reduced the binding of N-methyl(R)salsolinol with simultaneous reduction in the MAO activity.	salsoline	70-91	monoamine oxidase A	Homo sapiens	27-32
16336631-6	2006	RNA interference targeting MAO-A significantly reduced the binding of N-methyl(R)salsolinol with simultaneous reduction in the MAO activity.	salsoline	70-91	monoamine oxidase A	Homo sapiens	27-30
15102525-0	2004	Neuroprotective function of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane, [R-(-)-BPAP], against apoptosis induced by N-methyl(R)salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoma SH-SY5Y cells.	salsoline	119-140	CD1b molecule	Homo sapiens	28-35
11520893-0	2001	Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol.	salsoline	206-227	BCL2 apoptosis regulator	Homo sapiens	22-27
11520893-0	2001	Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol.	salsoline	206-227	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	115-155
11520893-3	2001	In this paper, involvement of GAPDH in apoptosis induced by N-methyl(R)salsolinol was studied.	salsoline	60-81	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	30-35
11520893-6	2001	Overexpression of Bcl-2 prevented the decline in DeltaPsim and also apoptotic DNA damage induced by N-methyl(R)salsolinol.	salsoline	100-121	BCL2 apoptosis regulator	Homo sapiens	18-23
11520893-8	2001	In addition, a novel antiparkinsonian drug, rasagiline, prevented nuclear accumulation of GAPDH induced by N-methyl(R)salsolinol in control cells.	salsoline	107-128	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	90-95
2296014-2	1990	None were found to be a substrate for either enzyme, but many of these isoquinolines could selectively inhibit either MAO A or B. Stereoselective competitive inhibition of MAO A was found with the R enantiomer of all the stereoisomers tested, including salsolinol (Ki = 31 microM), salsoline (Ki = 77 microM), salsolidine (Ki = 6 microM), and carnegine (Ki = 2 microM).	salsoline	282-291	monoamine oxidase A	Homo sapiens	118-123
11008878-4	2000	The activity of a neutral N-methyltransferase in the striatum was found to determine the level of MPP+-like 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, an oxidation product of N-methyl(R)salsolinol in the substantia nigra.	salsoline	178-199	M-phase phosphoprotein 6	Homo sapiens	98-101
11188501-2	2000	N-Methyl (R)salsolinol [NM (R) Sal] is a candidate of dopaminergic neurotoxins, and is synthesized from dopamine by 2 enzymes: (R) Salsolinol synthase and a neutral (R) Salsolinol N-methyltransferase (nNMT).	salsoline	0-22	nicotinamide N-methyltransferase	Homo sapiens	201-205
10380999-0	1999	Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, is mediated by activation of caspase 3.	salsoline	47-68	caspase 3	Homo sapiens	99-108
10380999-6	1999	These results demonstrate that caspase 3 mediates apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, which may cause apoptotic cell death of dopamine neurons in Parkinson"s disease.	salsoline	97-118	caspase 3	Homo sapiens	31-40
9275315-3	1997	Quantification of the products showed that O-methylation of (+)-(R)-salsolinol by soluble COMT afforded the 7-O-methylated product salsoline preferentially, whereas (-)-(s)-salsolinol yielded almost equivalent amounts of the 6- and 7-methyl ethers.	salsoline	131-140	catechol-O-methyltransferase	Sus scrofa	90-94
2296014-2	1990	None were found to be a substrate for either enzyme, but many of these isoquinolines could selectively inhibit either MAO A or B. Stereoselective competitive inhibition of MAO A was found with the R enantiomer of all the stereoisomers tested, including salsolinol (Ki = 31 microM), salsoline (Ki = 77 microM), salsolidine (Ki = 6 microM), and carnegine (Ki = 2 microM).	salsoline	282-291	monoamine oxidase A	Homo sapiens	172-177