PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12942549-5	2003	Aprotinin, a plasmin inhibitor, and mannosamine, which inhibits the synthesis of glycosylphosphatidylinositol (GPI), thereby preventing anchorage of GPI-linked proteins such as uPAR to the cell membrane, also decreased IGF-II- (P<0.05 for both) but not IGF-I-induced migration.	mannosamine	36-47	plasminogen activator, urokinase receptor	Homo sapiens	177-181
17401531-3	2007	We have shown that amino sugars (galactosamine, glucosamine and mannosamine), which are not SSAO substrates, can bind to the enzyme as reversible inhibitors.	mannosamine	64-75	amine oxidase copper containing 3	Homo sapiens	92-96
15780640-8	2005	Addition of either 1.35 mM ManN or 31-500 microM EST blocked IL-1-mediated aggrecanolysis and this was accompanied by nearly complete inhibition of the MT4-MMP increase, the p68 loss and the formation of p53.	mannosamine	27-31	DNA polymerase delta 3, accessory subunit	Bos taurus	174-177
19596068-4	2009	In affected individuals distinct mutations have been identified in the GNE gene, which encodes the bifunctional enzyme uridine diphospho-N-acetylglucosamine (UDP-GlcNAc) 2-epimerase/N-acetyl-mannosamine (ManNAc) kinase (GNE/MNK).	mannosamine	190-202	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	71-74
16645232-9	2006	Serum KL-6 levels at 40 Gy in patients who developed RP were higher than those without it (p = 0.0363, Mann-Whitney U test).	mannosamine	103-107	mucin 1, cell surface associated	Homo sapiens	6-10
15478002-8	2005	In contrast to the effects of tunicamycin on N-linked glycosylation, the effects of mannosamine, which inhibits GPI-anchor glycosylation/formation, included (1) an increase in cell layer protein; (2) decreases in sALP specific activity, in the cells and in the CM; and (3) increases in the percentages of both anchorless and wheat germ agglutinin (WGA)-soluble sALP in the medium, but not in the cells (P <0.005 for each).	mannosamine	84-95	glucose-6-phosphate isomerase	Homo sapiens	112-115
14561743-5	2003	The Lec3 phenotype was rescued by exogenously added N-acetylmannosamine or mannosamine but not by the same concentrations of N-acetylglucosamine, glucosamine, glucose, or mannose.	mannosamine	60-71	adhesion G protein-coupled receptor L3	Homo sapiens	4-8
12942549-5	2003	Aprotinin, a plasmin inhibitor, and mannosamine, which inhibits the synthesis of glycosylphosphatidylinositol (GPI), thereby preventing anchorage of GPI-linked proteins such as uPAR to the cell membrane, also decreased IGF-II- (P<0.05 for both) but not IGF-I-induced migration.	mannosamine	36-47	insulin like growth factor 2	Homo sapiens	219-225
12942549-5	2003	Aprotinin, a plasmin inhibitor, and mannosamine, which inhibits the synthesis of glycosylphosphatidylinositol (GPI), thereby preventing anchorage of GPI-linked proteins such as uPAR to the cell membrane, also decreased IGF-II- (P<0.05 for both) but not IGF-I-induced migration.	mannosamine	36-47	insulin like growth factor 1	Homo sapiens	219-224
10860843-4	2000	Furthermore, treatment with mannosamine, which blocks GPI-anchor formation, decreased specific HDL3-binding in a dose-dependent manner.	mannosamine	28-39	HDL3	Homo sapiens	95-99
10491182-11	1999	The prevention of glycosyl phosphatidylinositol moiety synthesis and interference with uPAR anchoring to the cell surface using mannosamine also abolished Ca2+ signals.	mannosamine	128-139	plasminogen activator, urokinase receptor	Homo sapiens	87-91
10640399-2	2000	Recent studies have demonstrated that the hexosamines glucosamine (GlcN) and mannosamine (ManN) can inhibit aggrecanase-mediated cleavage of aggrecan in IL-1-treated cartilage cultures.	mannosamine	77-88	interleukin 1 alpha	Homo sapiens	153-157
10640399-2	2000	Recent studies have demonstrated that the hexosamines glucosamine (GlcN) and mannosamine (ManN) can inhibit aggrecanase-mediated cleavage of aggrecan in IL-1-treated cartilage cultures.	mannosamine	90-94	interleukin 1 alpha	Homo sapiens	153-157
10640399-5	2000	After 6 days of culture in 10 ng/ml IL-1 plus ManN, mechanical testing of explants in confined compression demonstrated that ManN inhibited the IL-1alpha-induced degradation in tissue equilibrium modulus, dynamic stiffness, streaming potential, and hydraulic permeability, in a dose-dependent fashion, with peak inhibition ( approximately 75-100% inhibition) reached by a concentration of 1.35 mM.	mannosamine	125-129	interleukin 1 alpha	Homo sapiens	36-40
10640399-5	2000	After 6 days of culture in 10 ng/ml IL-1 plus ManN, mechanical testing of explants in confined compression demonstrated that ManN inhibited the IL-1alpha-induced degradation in tissue equilibrium modulus, dynamic stiffness, streaming potential, and hydraulic permeability, in a dose-dependent fashion, with peak inhibition ( approximately 75-100% inhibition) reached by a concentration of 1.35 mM.	mannosamine	125-129	interleukin 1 alpha	Homo sapiens	144-153
9162074-9	1997	Mannosamine treatment, which down-regulates cell-surface uPAR, decreased MEF-2 migration by 40% without significantly affecting MEF-1 migration.	mannosamine	0-11	plasminogen activator, urokinase receptor	Mus musculus	57-61
11672041-1	1998	Oxidation of D-mannosamine (1), D-glucosamine (2), and D-galctosamine (3) by sodium N-chlorobenzenesulfonamide or chloramine-B (CAB) at 313 K is followed by a shortening of carbon chain and obeys the rate law, rate = k[CAB][sugar][HO(-)](x)(), where x is less than unity.	mannosamine	13-26	neural proliferation, differentiation and control 1	Homo sapiens	114-126
11672041-1	1998	Oxidation of D-mannosamine (1), D-glucosamine (2), and D-galctosamine (3) by sodium N-chlorobenzenesulfonamide or chloramine-B (CAB) at 313 K is followed by a shortening of carbon chain and obeys the rate law, rate = k[CAB][sugar][HO(-)](x)(), where x is less than unity.	mannosamine	13-26	neural proliferation, differentiation and control 1	Homo sapiens	128-131
11672041-1	1998	Oxidation of D-mannosamine (1), D-glucosamine (2), and D-galctosamine (3) by sodium N-chlorobenzenesulfonamide or chloramine-B (CAB) at 313 K is followed by a shortening of carbon chain and obeys the rate law, rate = k[CAB][sugar][HO(-)](x)(), where x is less than unity.	mannosamine	13-26	neural proliferation, differentiation and control 1	Homo sapiens	219-222
10395742-6	1999	This effect of mannosamine appears to be due to its capacity to inhibit the synthesis of glycosylphosphatidylinositol (GPI)-linked proteins by chondrocytes since the GPI synthesis inhibitor 2-deoxyfluoroglucose (2-DFG) also inhibited the aggrecanase response to IL-1b and RA in rat cells.	mannosamine	15-26	interleukin 1 beta	Rattus norvegicus	262-267
9162074-9	1997	Mannosamine treatment, which down-regulates cell-surface uPAR, decreased MEF-2 migration by 40% without significantly affecting MEF-1 migration.	mannosamine	0-11	myocyte enhancer factor 2C	Mus musculus	73-78
6495268-1	1984	The amino sugars glucosamine, galactosamine and mannosamine (30 mM) inhibited aggregation of human or rabbit platelets induced by ADP, collagen, thrombin, PAF or high concentrations of sodium arachidonate.	mannosamine	48-59	prothrombin	Oryctolagus cuniculus	145-153
3298291-7	1987	The detected alpha-glucosidase activity was strongly inhibited by free mannosamine.	mannosamine	71-82	sucrase-isomaltase	Homo sapiens	13-30
2947567-9	1986	The N-acetyl-beta-glucosaminidase activities of both isoenzymes are strongly inhibited, in decreasing order, by N-acetyl-galactosamine, mannosamine, disaccharic acid lactone, N-acetylglucosamine and gluconolactone.	mannosamine	136-147	O-GlcNAcase	Homo sapiens	4-33
8496158-2	1993	In this paper, the effect of ManN on the synthesis of putative GPI anchor precursors in mammalian cells was studied.	mannosamine	29-33	glucose-6-phosphate isomerase	Homo sapiens	63-66
6841529-0	1983	Analysis of sialic acids by gas chromatography of the mannosamine derivatives released by the action of N-acetylneuraminate lyase.	mannosamine	54-65	N-acetylneuraminate pyruvate lyase	Homo sapiens	104-129
6897258-6	1982	Inhibition of FMLP-induced chemotaxis by WGA was not reversed by washing WGA-treated cells, but was reversed (and prevented) by N-acetyl-D-glucosamine (not by N-acetyl-D-galactosamine or mannosamine).	mannosamine	187-198	formyl peptide receptor 1	Homo sapiens	14-18
33303737-2	2020	Here we report the identification of the hexosamine D-mannosamine (ManN) as an EC mitogen and survival factor for bovine and human microvascular EC, with an additivity with VEGF.	mannosamine	52-65	vascular endothelial growth factor A	Homo sapiens	173-177
6213638-2	1982	The formation of the fibrinogen-thrombospondin complex was specific, saturable, and partially inhibited by mannosamine, glucosamine, and arginine.	mannosamine	107-118	fibrinogen beta chain	Homo sapiens	21-31
7316960-1	1981	THe beta-galactoside-binding lectin binds to glucosamine, mannosamine and galactosamine in addition to beta-galactoside, as determined by the inhibition of haemagglutination.	mannosamine	58-69	galectin 1A	Gallus gallus	4-35
33303737-2	2020	Here we report the identification of the hexosamine D-mannosamine (ManN) as an EC mitogen and survival factor for bovine and human microvascular EC, with an additivity with VEGF.	mannosamine	67-71	vascular endothelial growth factor A	Homo sapiens	173-177
28796447-5	2017	PFAA-derivatized mannosamine and galactosamine were successfully transformed into cell-surface glycans and efficiently labeled with phosphine-derivatized fluorophore-conjugated bovine serum albumin.	mannosamine	17-28	albumin	Homo sapiens	184-197
23122659-10	2012	These preclinical data strongly support further evaluation of oral ManNAc, Neu5Ac and ManN as therapy for GNE myopathy and conceivably for certain glomerular diseases with hyposialylation.	mannosamine	67-71	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	106-109
28795601-2	2017	This work evaluated the impact of surface modifications of mannosamine-conjugated multifunctional poly(glutamic acid) (PG)-dendrimers as nanocarriers of the tumour associated antigens (TAA) MART-1, gp100:44 and gp100:209.	mannosamine	59-70	premelanosome protein	Homo sapiens	198-203
28795601-2	2017	This work evaluated the impact of surface modifications of mannosamine-conjugated multifunctional poly(glutamic acid) (PG)-dendrimers as nanocarriers of the tumour associated antigens (TAA) MART-1, gp100:44 and gp100:209.	mannosamine	59-70	premelanosome protein	Homo sapiens	211-216
22921741-8	2012	The different stereochemistry of the N-acetyl group at position C(2) of mannosamine (MenA CPS) and glucosamine (MenX CPS) respectively might play a fundamental role in this susceptibility to polysaccharide chain degradation.	mannosamine	72-83	ENAH actin regulator	Homo sapiens	85-89
19909832-3	2010	DESIGN: HEK293F and CHO-K1 cells transiently transfected with ADAMTS5 cDNA were treated with glucosamine or the related hexosamine mannosamine.	mannosamine	131-142	A disintegrin and metalloproteinase with thrombospondin motifs 5	Cricetulus griseus	62-69
19909832-7	2010	RESULTS: Ten mM glucosamine and 5-10mM mannosamine reduced excision of the ADAMTS5 propeptide, indicating interference with the propeptide excision mechanism, although mannosamine compromised cell viability at these doses.	mannosamine	39-50	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	75-82
20045674-2	2010	We found that amino sugars with a free amino group such as glucosamine, galactosamine and mannosamine induced autophagy via an mTOR-independent pathway.	mannosamine	90-101	mechanistic target of rapamycin kinase	Homo sapiens	127-131