PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 12895692-2 2003 We report that nanomolar concentrations of 12-deoxyphorbol 13-phenylacetate (DPP), an anti-tumor-promoting phorbol ester originally isolated from a West African plant, induce the expression of HIV-1 in latently infected T cells and render them sensitive to killing by an immunotoxin targeted to the viral envelope glycoprotein. 12-deoxyphorbolphenylacetate 43-75 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 305-326 12895692-2 2003 We report that nanomolar concentrations of 12-deoxyphorbol 13-phenylacetate (DPP), an anti-tumor-promoting phorbol ester originally isolated from a West African plant, induce the expression of HIV-1 in latently infected T cells and render them sensitive to killing by an immunotoxin targeted to the viral envelope glycoprotein. 12-deoxyphorbolphenylacetate 77-80 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 305-326 7756173-9 1995 Selective down-regulation of PKC isoforms by either 12-deoxyphorbol-13-phenylacetate or bryostatin 1 inhibited Ca(2+)-induced expression of differentiation markers at doses most specific for the down-regulation of PKC alpha. 12-deoxyphorbolphenylacetate 52-84 protein kinase C, alpha Mus musculus 29-32 7870033-1 1995 12-Deoxyphorbol-13-phenylacetate (dPP) is the prototype for a new class of phorbol derivatives that function as protein kinase C (PKC) activators with potent anti-tumor-promoting activity. 12-deoxyphorbolphenylacetate 0-32 protein kinase C, alpha Mus musculus 130-133 7870033-1 1995 12-Deoxyphorbol-13-phenylacetate (dPP) is the prototype for a new class of phorbol derivatives that function as protein kinase C (PKC) activators with potent anti-tumor-promoting activity. 12-deoxyphorbolphenylacetate 34-37 protein kinase C, alpha Mus musculus 130-133 7870033-2 1995 To explore the mechanism of action of dPP, we have conducted detailed analyses of the translocation and down-regulation patterns of individual PKC isozymes in mouse primary keratinocytes upon dPP treatment. 12-deoxyphorbolphenylacetate 192-195 protein kinase C, alpha Mus musculus 143-146 7870033-6 1995 As was the case with translocation, dPP down-regulated the novel PKC isozymes (delta, epsilon, and eta) with 2 orders of magnitude higher potency (ED50, about 1-2 nM), compared with PKC-alpha (ED50, about 100 nM). 12-deoxyphorbolphenylacetate 36-39 protein kinase C, alpha Mus musculus 65-68 7870033-6 1995 As was the case with translocation, dPP down-regulated the novel PKC isozymes (delta, epsilon, and eta) with 2 orders of magnitude higher potency (ED50, about 1-2 nM), compared with PKC-alpha (ED50, about 100 nM). 12-deoxyphorbolphenylacetate 36-39 endothelin receptor type A Mus musculus 78-102 7870033-7 1995 dPP induced transglutaminase activity, ornithine decarboxylase activity, and cornification with potencies similar to that for PKC-alpha translocation. 12-deoxyphorbolphenylacetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 39-62 7870033-8 1995 On the other hand, dPP caused inhibition of EGF binding with a potency similar to that for the translocation of the novel PKC isozymes. 12-deoxyphorbolphenylacetate 19-22 protein kinase C, alpha Mus musculus 122-125 7870033-9 1995 Although the generality of its selectivity in different cell types remains to be determined, at least in keratinocytes dPP is a powerful tool for dissecting the involvement of the classical and novel PKC isozymes in biological responses. 12-deoxyphorbolphenylacetate 119-122 protein kinase C, alpha Mus musculus 200-203 7870033-10 1995 The unique regulatory pattern of PKC-epsilon could contribute to the anti-tumor-promoting activity of dPP. 12-deoxyphorbolphenylacetate 102-105 protein kinase C, epsilon Mus musculus 33-44 1988110-6 1991 However, 12-deoxyphorbol 13-phenylacetate and 12-deoxyphorbol 13-phenylacetate-20-acetate were required at nearly 100-fold higher concentrations than TPA to suppress IL-2 production, suppress mitogenesis, and cause down-regulation of protein kinase C. A comparison of structures indicated that an R group at the 12-position was less important for IL-2 production and mitogenesis than for down-regulation of protein kinase C and the suppression of mitogenesis. 12-deoxyphorbolphenylacetate 9-41 interleukin 2 Homo sapiens 166-170 1988110-6 1991 However, 12-deoxyphorbol 13-phenylacetate and 12-deoxyphorbol 13-phenylacetate-20-acetate were required at nearly 100-fold higher concentrations than TPA to suppress IL-2 production, suppress mitogenesis, and cause down-regulation of protein kinase C. A comparison of structures indicated that an R group at the 12-position was less important for IL-2 production and mitogenesis than for down-regulation of protein kinase C and the suppression of mitogenesis. 12-deoxyphorbolphenylacetate 9-41 interleukin 2 Homo sapiens 347-351 3708006-2 1986 Preincubation of the platelets with either TPA or 12-deoxyphorbol 13-phenylacetate, but not the parent, 4-beta-phorbol, produced a dose-dependent inhibition of the elevation of [Ca2+]i and 5-hydroxytryptamine release induced by human alpha-thrombin. 12-deoxyphorbolphenylacetate 50-82 coagulation factor II, thrombin Homo sapiens 240-248 10200423-4 1999 Maximal activation of PKC using the phorbol esters, 4beta-phorbol 12-myristate, 13-acetate (PMA), phorbol 12, 13 dibutyrate (PDBu) and 12-deoxyphorbol 13-phenylacetate (dPPA) elicited a rapid, and sustained, inhibition of the outward steady-state voltage- and calcium- dependent potassium current predominantly carried through BK channels. 12-deoxyphorbolphenylacetate 135-167 protein kinase C, alpha Mus musculus 22-25 10200423-4 1999 Maximal activation of PKC using the phorbol esters, 4beta-phorbol 12-myristate, 13-acetate (PMA), phorbol 12, 13 dibutyrate (PDBu) and 12-deoxyphorbol 13-phenylacetate (dPPA) elicited a rapid, and sustained, inhibition of the outward steady-state voltage- and calcium- dependent potassium current predominantly carried through BK channels. 12-deoxyphorbolphenylacetate 169-173 protein kinase C, alpha Mus musculus 22-25 18475617-3 1995 Rises in perfusion pressure in response to ET-1 (10(-8) M)or DOPPA (10(-6) M) were reduced significantly by pre-treatment with either the ET(A) receptor antagonist PD151242 (10(-6) M) or the PKC inhibitor Ro 31-8220 (10(-6) M). 12-deoxyphorbolphenylacetate 61-66 protein kinase C, gamma Rattus norvegicus 191-194 7961621-2 1994 PDBu and dPP showed a very rapid release from the cells (t1/2 = 1 min), whereas PMA showed a slower release (t1/2 = 9 min). 12-deoxyphorbolphenylacetate 9-12 brachyury, T-box transcription factor T Mus musculus 57-65 7961621-4 1994 Washes of 5-15 min resulted in complete redistribution of the PKC isozymes when the cells were previously treated with 1 microM dPP or 1 microM PDBu for 5 min. 12-deoxyphorbolphenylacetate 128-131 protein kinase C, alpha Mus musculus 62-65 7961621-6 1994 Longer initial treatments with PMA, dPP, and PDBu (up to 60 min) translocated PKC in a very similar, completely reversible fashion. 12-deoxyphorbolphenylacetate 36-39 protein kinase C, alpha Mus musculus 78-81 21566991-2 1994 demonstration of molecular and biochemical heterogeneity of PKC, we examined the effect of 12-deoxyphorbol 13-phenylacetate (dPP) on intracellular accumulation and drug sensitivity of daunorubicin (DNR) in drug sensitive P388 murine leukemia cell line. 12-deoxyphorbolphenylacetate 91-123 decapentaplegic Drosophila melanogaster 125-128 8313525-4 1994 Prolonged treatment (> 6 h) of cultures in down-modulation studies is complicated by the metabolism of DOPPA to 12-deoxyphorbol-13-phenylacetate (DOPP), a compound which activates all PKC isozymes tested in vitro (Ryves, W. J., et al. 12-deoxyphorbolphenylacetate 115-147 protein kinase C, beta Mus musculus 187-190 8495413-1 1993 Prostratin and 12-deoxyphorbol 13-phenylacetate (dPP) form a new class of protein kinase C activators of unique biological activity. 12-deoxyphorbolphenylacetate 15-47 decapentaplegic Drosophila melanogaster 49-52 6111891-8 1981 In addition propranolol, which inhibits stimulus activation of phospholipase A2, produced 70% and 55% inhibition of the reaction of mice ears to 12-DOPPA and 12-DOPPAA. 12-deoxyphorbolphenylacetate 145-153 phospholipase A2, group IB, pancreas Mus musculus 63-79