PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
10200423-4	1999	Maximal activation of PKC using the phorbol esters, 4beta-phorbol 12-myristate, 13-acetate (PMA), phorbol 12, 13 dibutyrate (PDBu) and 12-deoxyphorbol 13-phenylacetate (dPPA) elicited a rapid, and sustained, inhibition of the outward steady-state voltage- and calcium- dependent potassium current predominantly carried through BK channels.	12-deoxyphorbolphenylacetate	135-167	protein kinase C, alpha	Mus musculus	22-25
12895692-2	2003	We report that nanomolar concentrations of 12-deoxyphorbol 13-phenylacetate (DPP), an anti-tumor-promoting phorbol ester originally isolated from a West African plant, induce the expression of HIV-1 in latently infected T cells and render them sensitive to killing by an immunotoxin targeted to the viral envelope glycoprotein.	12-deoxyphorbolphenylacetate	43-75	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	305-326
12895692-2	2003	We report that nanomolar concentrations of 12-deoxyphorbol 13-phenylacetate (DPP), an anti-tumor-promoting phorbol ester originally isolated from a West African plant, induce the expression of HIV-1 in latently infected T cells and render them sensitive to killing by an immunotoxin targeted to the viral envelope glycoprotein.	12-deoxyphorbolphenylacetate	77-80	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	305-326
10200423-4	1999	Maximal activation of PKC using the phorbol esters, 4beta-phorbol 12-myristate, 13-acetate (PMA), phorbol 12, 13 dibutyrate (PDBu) and 12-deoxyphorbol 13-phenylacetate (dPPA) elicited a rapid, and sustained, inhibition of the outward steady-state voltage- and calcium- dependent potassium current predominantly carried through BK channels.	12-deoxyphorbolphenylacetate	169-173	protein kinase C, alpha	Mus musculus	22-25
18475617-3	1995	Rises in perfusion pressure in response to ET-1 (10(-8) M)or DOPPA (10(-6) M) were reduced significantly by pre-treatment with either the ET(A) receptor antagonist PD151242 (10(-6) M) or the PKC inhibitor Ro 31-8220 (10(-6) M).	12-deoxyphorbolphenylacetate	61-66	protein kinase C, gamma	Rattus norvegicus	191-194
7756173-9	1995	Selective down-regulation of PKC isoforms by either 12-deoxyphorbol-13-phenylacetate or bryostatin 1 inhibited Ca(2+)-induced expression of differentiation markers at doses most specific for the down-regulation of PKC alpha.	12-deoxyphorbolphenylacetate	52-84	protein kinase C, alpha	Mus musculus	29-32
7870033-1	1995	12-Deoxyphorbol-13-phenylacetate (dPP) is the prototype for a new class of phorbol derivatives that function as protein kinase C (PKC) activators with potent anti-tumor-promoting activity.	12-deoxyphorbolphenylacetate	0-32	protein kinase C, alpha	Mus musculus	130-133
7870033-1	1995	12-Deoxyphorbol-13-phenylacetate (dPP) is the prototype for a new class of phorbol derivatives that function as protein kinase C (PKC) activators with potent anti-tumor-promoting activity.	12-deoxyphorbolphenylacetate	34-37	protein kinase C, alpha	Mus musculus	130-133
7870033-2	1995	To explore the mechanism of action of dPP, we have conducted detailed analyses of the translocation and down-regulation patterns of individual PKC isozymes in mouse primary keratinocytes upon dPP treatment.	12-deoxyphorbolphenylacetate	192-195	protein kinase C, alpha	Mus musculus	143-146
7870033-6	1995	As was the case with translocation, dPP down-regulated the novel PKC isozymes (delta, epsilon, and eta) with 2 orders of magnitude higher potency (ED50, about 1-2 nM), compared with PKC-alpha (ED50, about 100 nM).	12-deoxyphorbolphenylacetate	36-39	protein kinase C, alpha	Mus musculus	65-68
7870033-6	1995	As was the case with translocation, dPP down-regulated the novel PKC isozymes (delta, epsilon, and eta) with 2 orders of magnitude higher potency (ED50, about 1-2 nM), compared with PKC-alpha (ED50, about 100 nM).	12-deoxyphorbolphenylacetate	36-39	endothelin receptor type A	Mus musculus	78-102
7870033-7	1995	dPP induced transglutaminase activity, ornithine decarboxylase activity, and cornification with potencies similar to that for PKC-alpha translocation.	12-deoxyphorbolphenylacetate	0-3	ornithine decarboxylase, structural 1	Mus musculus	39-62
7870033-8	1995	On the other hand, dPP caused inhibition of EGF binding with a potency similar to that for the translocation of the novel PKC isozymes.	12-deoxyphorbolphenylacetate	19-22	protein kinase C, alpha	Mus musculus	122-125
7870033-9	1995	Although the generality of its selectivity in different cell types remains to be determined, at least in keratinocytes dPP is a powerful tool for dissecting the involvement of the classical and novel PKC isozymes in biological responses.	12-deoxyphorbolphenylacetate	119-122	protein kinase C, alpha	Mus musculus	200-203
7870033-10	1995	The unique regulatory pattern of PKC-epsilon could contribute to the anti-tumor-promoting activity of dPP.	12-deoxyphorbolphenylacetate	102-105	protein kinase C, epsilon	Mus musculus	33-44
7961621-2	1994	PDBu and dPP showed a very rapid release from the cells (t1/2 = 1 min), whereas PMA showed a slower release (t1/2 = 9 min).	12-deoxyphorbolphenylacetate	9-12	brachyury, T-box transcription factor T	Mus musculus	57-65
7961621-4	1994	Washes of 5-15 min resulted in complete redistribution of the PKC isozymes when the cells were previously treated with 1 microM dPP or 1 microM PDBu for 5 min.	12-deoxyphorbolphenylacetate	128-131	protein kinase C, alpha	Mus musculus	62-65
7961621-6	1994	Longer initial treatments with PMA, dPP, and PDBu (up to 60 min) translocated PKC in a very similar, completely reversible fashion.	12-deoxyphorbolphenylacetate	36-39	protein kinase C, alpha	Mus musculus	78-81
8495413-1	1993	Prostratin and 12-deoxyphorbol 13-phenylacetate (dPP) form a new class of protein kinase C activators of unique biological activity.	12-deoxyphorbolphenylacetate	15-47	decapentaplegic	Drosophila melanogaster	49-52
21566991-2	1994	demonstration of molecular and biochemical heterogeneity of PKC, we examined the effect of 12-deoxyphorbol 13-phenylacetate (dPP) on intracellular accumulation and drug sensitivity of daunorubicin (DNR) in drug sensitive P388 murine leukemia cell line.	12-deoxyphorbolphenylacetate	91-123	decapentaplegic	Drosophila melanogaster	125-128
8313525-4	1994	Prolonged treatment (> 6 h) of cultures in down-modulation studies is complicated by the metabolism of DOPPA to 12-deoxyphorbol-13-phenylacetate (DOPP), a compound which activates all PKC isozymes tested in vitro (Ryves, W. J., et al.	12-deoxyphorbolphenylacetate	115-147	protein kinase C, beta	Mus musculus	187-190
3708006-2	1986	Preincubation of the platelets with either TPA or 12-deoxyphorbol 13-phenylacetate, but not the parent, 4-beta-phorbol, produced a dose-dependent inhibition of the elevation of [Ca2+]i and 5-hydroxytryptamine release induced by human alpha-thrombin.	12-deoxyphorbolphenylacetate	50-82	coagulation factor II, thrombin	Homo sapiens	240-248
1988110-6	1991	However, 12-deoxyphorbol 13-phenylacetate and 12-deoxyphorbol 13-phenylacetate-20-acetate were required at nearly 100-fold higher concentrations than TPA to suppress IL-2 production, suppress mitogenesis, and cause down-regulation of protein kinase C. A comparison of structures indicated that an R group at the 12-position was less important for IL-2 production and mitogenesis than for down-regulation of protein kinase C and the suppression of mitogenesis.	12-deoxyphorbolphenylacetate	9-41	interleukin 2	Homo sapiens	166-170
1988110-6	1991	However, 12-deoxyphorbol 13-phenylacetate and 12-deoxyphorbol 13-phenylacetate-20-acetate were required at nearly 100-fold higher concentrations than TPA to suppress IL-2 production, suppress mitogenesis, and cause down-regulation of protein kinase C. A comparison of structures indicated that an R group at the 12-position was less important for IL-2 production and mitogenesis than for down-regulation of protein kinase C and the suppression of mitogenesis.	12-deoxyphorbolphenylacetate	9-41	interleukin 2	Homo sapiens	347-351
6111891-8	1981	In addition propranolol, which inhibits stimulus activation of phospholipase A2, produced 70% and 55% inhibition of the reaction of mice ears to 12-DOPPA and 12-DOPPAA.	12-deoxyphorbolphenylacetate	145-153	phospholipase A2, group IB, pancreas	Mus musculus	63-79