PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9808673-0	1998	20beta-hydroxysteroid dehydrogenase catalyzes ketone-reduction of acetohexamide, an oral antidiabetic drug, in liver microsomes of adult male rats.	Acetohexamide	66-79	carbonyl reductase 1	Rattus norvegicus	0-35
15635190-1	2005	Acetohexamide (AH) is reduced to its alcohol metabolite by carbonyl reductase.	Acetohexamide	15-17	dehydrogenase/reductase 4	Rattus norvegicus	59-77
10328570-3	1999	Testectomy was found to decrease the plasma clearance (CLp) of acetohexamide in male rats, whereas ovariectomy had no effect on the CLp of acetohexamide in female animals, suggesting that androgens regulate the pharmacokinetics of acetohexamide.	Acetohexamide	63-76	coactosin-like F-actin binding protein 1	Rattus norvegicus	55-58
10328570-4	1999	The co-administration of sulfamethazine, which is known to be metabolized by a male-specific cytochrome P450 (CYP) isoform (CYP2C11), significantly decreased the CLp of acetohexamide in male Wistar-IM rats.	Acetohexamide	169-182	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	124-131
10328570-4	1999	The co-administration of sulfamethazine, which is known to be metabolized by a male-specific cytochrome P450 (CYP) isoform (CYP2C11), significantly decreased the CLp of acetohexamide in male Wistar-IM rats.	Acetohexamide	169-182	coactosin-like F-actin binding protein 1	Rattus norvegicus	162-165
10328570-5	1999	Based on these results, it is reasonable to assume that the sex-dependent pharmacokinetics of acetohexamide observed in Wistar-IM rats is associated with the male-specific hydroxylation catalyzed by CYP2C11.	Acetohexamide	94-107	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	199-206
15635190-1	2005	Acetohexamide (AH) is reduced to its alcohol metabolite by carbonyl reductase.	Acetohexamide	0-13	dehydrogenase/reductase 4	Rattus norvegicus	59-77
15558648-1	2004	This study was designed to elucidate strain- and sex-related differences of carbonyl reductase activity in rat kidney by using the oral antidiabetic drug acetohexamide as substrate.	Acetohexamide	154-167	dehydrogenase/reductase 4	Rattus norvegicus	76-94
9808673-6	1998	Based on all results, we conclude that 20beta-hydroxysteroid dehydrogenase catalyzes the ketone-reduction of acetohexamide in liver microsomes of adult male rats.	Acetohexamide	109-122	carbonyl reductase 1	Rattus norvegicus	39-74
7632166-4	1995	The other drugs--haloperidol, metyrapone, loxoprofen, daunorubicin and acetohexamide--were highly reduced by carbonyl reductase and/or aldehyde reductase.	Acetohexamide	71-84	aldo-keto reductase family 1 member A1	Homo sapiens	135-153
30926317-5	2019	The recombinant rabbit DHRS11 reduced acetohexamide and 1,4-naphthoquinone, and was inhibited by tolbutamide and phenobarbital (RHAR-specific inhibitors), demonstrating its identity with RHAR.	Acetohexamide	38-51	LOW QUALITY PROTEIN: dehydrogenase/reductase SDR family member 11	Oryctolagus cuniculus	23-29
4028305-2	1985	Binding of acetohexamide and its major metabolite, (-)-hydroxyhexamide, to human serum albumin.	Acetohexamide	11-24	albumin	Homo sapiens	81-94
32429512-0	2020	In Vitro Investigations of Acetohexamide Binding to Glycated Serum Albumin in the Presence of Fatty Acid.	Acetohexamide	27-40	albumin	Homo sapiens	61-74
3668785-2	1987	Evidence obtained in this study suggests that the microsomal carbonyl reductase may contribute to the sex difference in the reductive metabolism of acetohexamide in rats.	Acetohexamide	148-161	dehydrogenase/reductase 4	Rattus norvegicus	61-79
26462924-3	2016	Several drug models (i.e., quinidine, diazepam, gliclazide, tolbutamide, and acetohexamide) were examined that represented a relatively wide range of therapeutic concentrations and affinities for human serum albumin (HSA).	Acetohexamide	77-90	albumin	Homo sapiens	202-215
29149600-6	2017	Acetohexamide exerted this protective function by antagonizing expression of the DNA glycosylase, MUTYH.	Acetohexamide	0-13	mutY DNA glycosylase	Homo sapiens	98-103
25451588-7	2015	It was determined that DHRS3 also participates in the metabolism of other endogenous compounds, such as androstenedione, estrone, and DL-glyceraldehyde, and in the biotransformation of xenobiotics (e.g., NNK and acetohexamide) in addition to all-trans-retinal.	Acetohexamide	212-225	dehydrogenase/reductase 3	Homo sapiens	23-28
25019556-7	2014	These inhibitors showed significant interactions with SFRP4 as compared to other inhibitors as well as control (acetohexamide).	Acetohexamide	112-125	secreted frizzled related protein 4	Homo sapiens	54-59
20829128-0	2010	Chromatographic analysis of acetohexamide binding to glycated human serum albumin.	Acetohexamide	28-41	albumin	Homo sapiens	68-81
20829128-1	2010	Acetohexamide is a drug used to treat type II diabetes and is tightly bound to the protein human serum albumin (HSA) in the circulation.	Acetohexamide	0-13	albumin	Homo sapiens	97-110