PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 26043942-11 2015 Finally, a significant decrease in DNAIC1 (dynein, axonemal, intermediate chain 1; the mouse ortholog of human DNAI1), a member of the DMC (dynein/dynactin motor complex), was noted in Dst(dt-Tg4) dorsal root ganglia and sensory neurons. dmc 135-138 dynein axonemal intermediate chain 1 Mus musculus 35-41 26328827-3 2015 DMC calculations using single-determinant trial wave functions of orbitals obtained from density functional theory calculations overestimate the binding energy, while DMC calculations using Hartree-Fock or CAS(4,8), complete active space trial functions significantly underestimate the binding energy. dmc 167-170 Cas scaffold protein family member 4 Homo sapiens 206-213 25159853-2 2015 We report a case of a 35-year-old man with BRAF(V600E) metastatic melanoma treated with dabrafenib (as well as ipilimumab and whole brain radiotherapy), who is alive, 25 months after the onset of his DMC. dmc 200-203 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 43-47 26043942-11 2015 Finally, a significant decrease in DNAIC1 (dynein, axonemal, intermediate chain 1; the mouse ortholog of human DNAI1), a member of the DMC (dynein/dynactin motor complex), was noted in Dst(dt-Tg4) dorsal root ganglia and sensory neurons. dmc 135-138 dynein axonemal intermediate chain 1 Homo sapiens 111-116 23843889-6 2013 The ability of DMC to activate AMPK in liver kinase (LK) B1-deficient MDA-MB-231 cells suggests that this activation was independent of LKB1-regulated cellular metabolic status. dmc 15-18 serine/threonine kinase 11 Homo sapiens 39-59 25423837-4 2014 The expression quantity of c-myc and hTERT mRNA were determined by semi-quantitative RT-PCR The effect of DMC on expression levels of cmyc and hTERT protein were measured by western blot. dmc 106-109 telomerase reverse transcriptase Homo sapiens 143-148 25423837-6 2014 CONCLUSION: DMC can induce SMMC-7721 cell apoptosis and the apoptosis mechanism may be related to the decreased mRNA and protein expression of c-myc and hTERT. dmc 12-15 MYC proto-oncogene, bHLH transcription factor Homo sapiens 143-148 25423837-6 2014 CONCLUSION: DMC can induce SMMC-7721 cell apoptosis and the apoptosis mechanism may be related to the decreased mRNA and protein expression of c-myc and hTERT. dmc 12-15 telomerase reverse transcriptase Homo sapiens 153-158 26417302-3 2014 Furthermore, DMC suppressed LPS-induced production of pro-inflammatory cytokines such as interleukin (IL)-1ss, IL-6, and tumor necrosis factor (TNF)-alpha. dmc 13-16 interleukin 6 Mus musculus 111-115 26417302-3 2014 Furthermore, DMC suppressed LPS-induced production of pro-inflammatory cytokines such as interleukin (IL)-1ss, IL-6, and tumor necrosis factor (TNF)-alpha. dmc 13-16 tumor necrosis factor Mus musculus 121-154 26417302-4 2014 To elucidate the mechanism underlying the anti-inflammatory activity of DMC, we assessed its effects on the mitogen-activated protein kinase (MAPK) pathway and the activity and expression of nuclear transcription factor kappa-B (NF-kappaB). dmc 72-75 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 220-227 26417302-4 2014 To elucidate the mechanism underlying the anti-inflammatory activity of DMC, we assessed its effects on the mitogen-activated protein kinase (MAPK) pathway and the activity and expression of nuclear transcription factor kappa-B (NF-kappaB). dmc 72-75 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 229-238 26417302-5 2014 The experiments demonstrated that DMC inhibited LPS-induced phosphorylation of extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinase (JNK), and p38. dmc 34-37 mitogen-activated protein kinase 8 Mus musculus 126-149 26417302-5 2014 The experiments demonstrated that DMC inhibited LPS-induced phosphorylation of extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinase (JNK), and p38. dmc 34-37 mitogen-activated protein kinase 8 Mus musculus 151-154 26417302-5 2014 The experiments demonstrated that DMC inhibited LPS-induced phosphorylation of extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinase (JNK), and p38. dmc 34-37 mitogen-activated protein kinase 14 Mus musculus 161-164 26417302-7 2014 Taken together, these data suggest that DMC exerts its anti-inflammatory effects in RAW 264.7 cells through the inhibition of LPS-stimulated NF-kappaB and MAPK signaling, thereby downregulating the expression of pro-inflammatory mediators. dmc 40-43 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 141-150 24498401-4 2014 Spectroscopic analysis using site specific probes on human serum albumin (HSA) clearly indicated that curcumin (Cur), demethylcurcumin (Dmc) and bisdemethoxycurcumin (Bdmc) bind to both Site I (sub-site Ia and Ib) and Site II on HSA. dmc 136-139 albumin Homo sapiens 59-72 25257244-5 2014 Mutation testing of DMC patients should be considered as BRAF inhibitors, and other novel targeted therapies may improve the bleak prognosis associated with this unusual presentation of metastatic melanoma. dmc 20-23 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 57-61 26417302-2 2014 Our results indicated that DMC downregulated LPS-induced nitric oxide (NO) synthase (iNOS) and cyclooxygenase-2 (COX-2) expression, thereby reducing the production of NO and prostaglandin E2 (PGE2) in LPS-activated RAW 264.7 cells. dmc 27-30 nitric oxide synthase 2, inducible Mus musculus 85-89 26417302-2 2014 Our results indicated that DMC downregulated LPS-induced nitric oxide (NO) synthase (iNOS) and cyclooxygenase-2 (COX-2) expression, thereby reducing the production of NO and prostaglandin E2 (PGE2) in LPS-activated RAW 264.7 cells. dmc 27-30 prostaglandin-endoperoxide synthase 2 Mus musculus 95-111 26417302-2 2014 Our results indicated that DMC downregulated LPS-induced nitric oxide (NO) synthase (iNOS) and cyclooxygenase-2 (COX-2) expression, thereby reducing the production of NO and prostaglandin E2 (PGE2) in LPS-activated RAW 264.7 cells. dmc 27-30 prostaglandin-endoperoxide synthase 2 Mus musculus 113-118 26858858-7 2013 The RNA expression of XIST and the methylation status of its promoter region suggested that DMC-iPSCs, when maintained undifferentiated and pluripotent, had three distinct states: (1) complete X-chromosome reactivation, (2) one inactive X-chromosome, or (3) an epigenetic aberration. dmc 92-95 X inactive specific transcript Homo sapiens 22-26 19026650-10 2009 In study II, the DMC assay detected 16 (59%) of 27 advanced adenoma samples that contained KRAS mutations, compared with 7% with the Hemoccult, 15% with the HemoccultSensa, and 26% with the PreGenPlus assays (P < .05 for each, compared with the DMC assay); specificities did not differ significantly. dmc 17-20 KRAS proto-oncogene, GTPase Homo sapiens 91-95 22090722-4 2011 Mutations in Dymeclin gene (DYM), mapped to chromosome 18q21.1, is responsible for DMC. dmc 83-86 dymeclin Homo sapiens 13-21 22090722-4 2011 Mutations in Dymeclin gene (DYM), mapped to chromosome 18q21.1, is responsible for DMC. dmc 83-86 dymeclin Homo sapiens 28-31 19652373-5 2009 The mechanism may involve that DMC attenuated L-type calcium channel alpha(1c) subunit increasing and Kv4.2 decreasing at both mRNA and protein level in diabetic rats. dmc 31-34 potassium voltage-gated channel subfamily D member 2 Rattus norvegicus 102-107 21176164-14 2010 Treatment with DMC elevated both mRNA and protein level of GluR2 in the NAm of DM rats, but had no effect on GABAA receptor expression. dmc 15-18 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 59-64 21176164-16 2010 Treatment with DMC also prevented the degeneration of neurons and myelinated axons in the brain stem NAm and reversed the down-regulation of GluR2 mRNA. dmc 15-18 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 141-146 16123214-1 2005 2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib that lacks COX-2 inhibitory function. dmc 24-27 prostaglandin-endoperoxide synthase 2 Homo sapiens 75-91 18508034-7 2008 However, in the cell-free assay DMC inhibits mPGES-1 to a maximum of 65% only and concentrations needed for inhibition of mPGES-1 activity are about 10-fold higher than needed for inhibition of PGE(2) production in cell culture. dmc 32-35 prostaglandin E synthase Mus musculus 45-52 16863303-13 2006 In this article the quantum solvation of HCN in small helium-4 droplets is studied using a new fixed-node diffusion Monte Carlo (DMC) procedure. dmc 129-132 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 41-44 16707021-1 2006 BACKGROUND: 2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex) that lacks COX-2-inhibitory function. dmc 36-39 prostaglandin-endoperoxide synthase 2 Homo sapiens 87-103 16707021-1 2006 BACKGROUND: 2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex) that lacks COX-2-inhibitory function. dmc 36-39 prostaglandin-endoperoxide synthase 2 Homo sapiens 105-110 19044853-1 2008 Diffusion quantum Monte Carlo (DMC) calculations for transition metal (M) porphyrin complexes (MPo, M=Ni,Cu,Zn) are reported. dmc 31-34 myeloperoxidase Homo sapiens 95-98 18508034-4 2008 This effect can be at least partly explained by our findings that DMC inhibits microsomal prostaglandin E synthase-1 (mPGES-1) activity in a cell-free assay. dmc 66-69 prostaglandin E synthase Homo sapiens 79-116 18508034-4 2008 This effect can be at least partly explained by our findings that DMC inhibits microsomal prostaglandin E synthase-1 (mPGES-1) activity in a cell-free assay. dmc 66-69 prostaglandin E synthase Mus musculus 118-125 18194272-3 2008 The DNA deoxymethylcytosine (dmC) content of purified CD4(+) T cells from 29 SLE patients and 30 healthy controls was measured by means of an enzyme-linked immunosorbent assay (ELISA). dmc 29-32 CD4 molecule Homo sapiens 54-57 18194272-6 2008 SLE patients had a significantly lower CD4(+) T-cell DNA dmC content than controls (0.802 +/- 0.134 versus 0.901 +/- 0.133) (P = 0.007). dmc 57-60 CD4 molecule Homo sapiens 39-42 16950518-11 2007 These results suggest that DL cultured in DMC for 18h, have the characteristics of lymphokine-activated killer (LAK) cells and are able to use efficiently both the perforin and the FasL cytolytic pathways. dmc 42-45 Fas ligand (TNF superfamily, member 6) Mus musculus 181-185 16707021-1 2006 BACKGROUND: 2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex) that lacks COX-2-inhibitory function. dmc 36-39 prostaglandin-endoperoxide synthase 2 Homo sapiens 154-159 16707021-9 2006 CONCLUSION: In consideration of survivin"s recognized role as a custodian of tumor cell survival, our results suggest that celecoxib and DMC might exert their cytotoxic anti-tumor effects at least in part via the down-regulation of survivin - in a manner that does not require the inhibition of cyclooxygenase-2. dmc 137-140 prostaglandin-endoperoxide synthase 2 Homo sapiens 295-311 16123214-1 2005 2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib that lacks COX-2 inhibitory function. dmc 24-27 prostaglandin-endoperoxide synthase 2 Homo sapiens 93-98 16793709-8 1998 A decrease in GP53-, P-selectin-, and LIBS-1-positive platelets was observed in the IDDM group with dmc: for GP53 17.4 +/- 1.0% (dmc) vs 23.4 +/- 1.0% (c), P < 0.05; for P-selectin 5.5 +/- 0.6% (dmc) vs 8.0+/-0.7% (c), P < 0.01 and for LIBS-1 8.3 +/- 0.9% (dmc) vs 15.8 +/- 1.3% (c), P < 0.01. dmc 100-103 selectin P Homo sapiens 21-31 15846081-5 2005 In cell culture, DMC effectively inhibits cell proliferation through the down-regulation of cyclins A and B and the ensuing loss of cyclin-dependent kinase activity. dmc 17-20 cyclin A2 Homo sapiens 92-107 14638437-5 2003 RESULTS: Regardless of the presence of mHLA-G1 expressing cells, the addition of the recombinant sub-sHLA-G1 protein in the DMC culture media decreased the amounts of tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, with the release of IL-4 from DMCs being unchanged. dmc 124-127 tumor necrosis factor Homo sapiens 167-200 16793709-8 1998 A decrease in GP53-, P-selectin-, and LIBS-1-positive platelets was observed in the IDDM group with dmc: for GP53 17.4 +/- 1.0% (dmc) vs 23.4 +/- 1.0% (c), P < 0.05; for P-selectin 5.5 +/- 0.6% (dmc) vs 8.0+/-0.7% (c), P < 0.01 and for LIBS-1 8.3 +/- 0.9% (dmc) vs 15.8 +/- 1.3% (c), P < 0.01. dmc 100-103 selectin P Homo sapiens 173-183 34506903-3 2021 Herein, we employed an unbiased thermal proteome profiling (TPP) method and identified multiple targets of DMC, including ALDH1A3, ALDH2, and PTGES2. dmc 107-110 aldehyde dehydrogenase 1 family member A3 Homo sapiens 122-129 34506903-3 2021 Herein, we employed an unbiased thermal proteome profiling (TPP) method and identified multiple targets of DMC, including ALDH1A3, ALDH2, and PTGES2. dmc 107-110 aldehyde dehydrogenase 2 family member Homo sapiens 131-136 34506903-3 2021 Herein, we employed an unbiased thermal proteome profiling (TPP) method and identified multiple targets of DMC, including ALDH1A3, ALDH2, and PTGES2. dmc 107-110 prostaglandin E synthase 2 Homo sapiens 142-148 34506903-4 2021 We further determined the dissociation constant (Kd) of DMC and ALDH1A3 to be 2.8 muM using microscale thermophoresis (MST) analysis, which indicated that DMC inhibited ALDH1A3 activity and aggravated cellular oxidative stress. dmc 56-59 aldehyde dehydrogenase 1 family member A3 Homo sapiens 64-71 34506903-4 2021 We further determined the dissociation constant (Kd) of DMC and ALDH1A3 to be 2.8 muM using microscale thermophoresis (MST) analysis, which indicated that DMC inhibited ALDH1A3 activity and aggravated cellular oxidative stress. dmc 56-59 aldehyde dehydrogenase 1 family member A3 Homo sapiens 169-176 34506903-4 2021 We further determined the dissociation constant (Kd) of DMC and ALDH1A3 to be 2.8 muM using microscale thermophoresis (MST) analysis, which indicated that DMC inhibited ALDH1A3 activity and aggravated cellular oxidative stress. dmc 155-158 aldehyde dehydrogenase 1 family member A3 Homo sapiens 64-71 34506903-4 2021 We further determined the dissociation constant (Kd) of DMC and ALDH1A3 to be 2.8 muM using microscale thermophoresis (MST) analysis, which indicated that DMC inhibited ALDH1A3 activity and aggravated cellular oxidative stress. dmc 155-158 aldehyde dehydrogenase 1 family member A3 Homo sapiens 169-176 34332078-6 2021 DMC-induced restoration of redox homeostasis was mediated via the activation of protein kinase Ctheta (PKCtheta) signaling. dmc 0-3 protein kinase C theta Homo sapiens 80-101 34332078-6 2021 DMC-induced restoration of redox homeostasis was mediated via the activation of protein kinase Ctheta (PKCtheta) signaling. dmc 0-3 protein kinase C theta Homo sapiens 103-111 34332078-4 2021 Mechanistically, DMC increased the expression of two critical intermediates in riboflavin metabolism: riboflavin kinase (RFK) and its metabolic product, flavin mononucleotide (FMN). dmc 17-20 riboflavin kinase Homo sapiens 102-119 34332078-4 2021 Mechanistically, DMC increased the expression of two critical intermediates in riboflavin metabolism: riboflavin kinase (RFK) and its metabolic product, flavin mononucleotide (FMN). dmc 17-20 riboflavin kinase Homo sapiens 121-124 74186-6 1977 Increased levels of chondroitin sulfate N-acetylgalactosamine-6-sulfate sulfatase and sulfamidase and decreased enzymic levels of arylsulfatase A and B (EC 3.1.6.1) were found in leucocytes of DMC patients. dmc 193-196 arylsulfatase A Homo sapiens 130-151 35508613-11 2022 Finally, exosome sequencing revealed LYPLAL1-DT expression was 4 times lower in DMC cells than in healthy samples. dmc 80-83 lysophospholipase like 1 Homo sapiens 37-44 35562866-11 2022 Overall, the present study demonstrates that the FA-based assay using the substrate pair R-I-Cad and DMC represents a facile, homogenous and continuous method for quantifying TGase 2 activity in cell lysates. dmc 101-104 transglutaminase 2 Homo sapiens 175-182 35446156-9 2022 Six-month repair outcomes showed that bilayered implantation of dMC-expanded zonal chondrocytes resulted in substantial recapitulation of zonal architecture, including chondrocyte arrangement, specific Proteoglycan 4 distribution, and collagen alignment, that was accompanied by healthier underlying subchondral bone. dmc 64-67 proteoglycan 4 Homo sapiens 202-216 3307014-5 1987 The incubation of rat or human plasma with degranulated mast cell (DMC) suspension did not cause the activation of plasma prekallikrein, but did cause a loss in the activity of coagulation factor XII, as ascertained by the lack of activation of prekallikrein in either the DMC-treated plasma by glass powder or in the incubation of DMC-treated human plasma with factor XII deficient plasma activated by kaolin. dmc 67-70 coagulation factor XII Homo sapiens 177-199 35333513-6 2022 For PsB, PsC, PsO, and PsF, our VMC and DMC total energies are lower than that from previous calculations; hence, we redefine the state of the art for these systems. dmc 40-43 insulin like growth factor binding protein 7 Homo sapiens 23-26 35153143-7 2022 The immunofluorescence results showed that POA leads to the accumulation of SQSTM1/p62 (P = 0.0083) but DMC supplementation could eliminate this (P < 0.0001). dmc 104-107 sequestosome 1 Mus musculus 76-82 31999832-3 2020 We aimed to investigate the relation between diabetic microvascular complications (DMC) and serum (Nrg-4) levels in patients with type 2 diabetes mellitus. dmc 83-86 neuregulin 4 Homo sapiens 99-104 588607-4 1977 The significant changes of fluorescence intensity and maximum position of MBA and DMC were found in the regions of phase transitions at 23, 42, 54 and 31c in liposomes from DML, DPL, DSL and mixture of DML and DPL, respectively. dmc 82-85 prion like protein doppel Homo sapiens 178-181 588607-4 1977 The significant changes of fluorescence intensity and maximum position of MBA and DMC were found in the regions of phase transitions at 23, 42, 54 and 31c in liposomes from DML, DPL, DSL and mixture of DML and DPL, respectively. dmc 82-85 prion like protein doppel Homo sapiens 210-213 32351054-6 2020 DMC conveniently integrates two orthogonal separation steps in a single column device: i) size exclusion to remove high-density lipoproteins (HDLs) that are smaller than EVs; and ii) cation exchange to clear positively charged ApoB100-containing LPPs, mostly (very) low-density lipoproteins (V)LDLs, from negatively charged EVs. dmc 0-3 apolipoprotein B Homo sapiens 227-234 32248551-2 2020 Some cases of DMC also demonstrate epidermal mucin the histologic appearance and staining properties of which have not been described in detail. dmc 14-17 LOC100508689 Homo sapiens 45-50 32248551-3 2020 METHODS: A total of 24 cases of DMC were investigated by routine hematoxylin-eosin (H&E) and alcian blue stains in addition to AE1/AE3 immunohistochemistry. dmc 32-35 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 127-130 32248551-4 2020 RESULTS: Nine out of the 24 cases of DMC demonstrated epidermal mucin. dmc 37-40 LOC100508689 Homo sapiens 64-69 33975446-9 2021 Flow cytometry revealed that 90% of the DMC subpopulation are HLA-G+, CD44+, CD73+, CD29+, CD105+, CD90+, and HLA-DR-. dmc 40-43 major histocompatibility complex, class I, G Homo sapiens 62-67 33975446-9 2021 Flow cytometry revealed that 90% of the DMC subpopulation are HLA-G+, CD44+, CD73+, CD29+, CD105+, CD90+, and HLA-DR-. dmc 40-43 CD44 molecule (Indian blood group) Homo sapiens 70-74 33975446-9 2021 Flow cytometry revealed that 90% of the DMC subpopulation are HLA-G+, CD44+, CD73+, CD29+, CD105+, CD90+, and HLA-DR-. dmc 40-43 5'-nucleotidase ecto Homo sapiens 77-81 33975446-9 2021 Flow cytometry revealed that 90% of the DMC subpopulation are HLA-G+, CD44+, CD73+, CD29+, CD105+, CD90+, and HLA-DR-. dmc 40-43 integrin subunit beta 1 Homo sapiens 84-88 33975446-9 2021 Flow cytometry revealed that 90% of the DMC subpopulation are HLA-G+, CD44+, CD73+, CD29+, CD105+, CD90+, and HLA-DR-. dmc 40-43 Thy-1 cell surface antigen Homo sapiens 99-103 33975446-10 2021 Reverse transcription-polymerase chain reaction revealed the expression of HLA-G in all of DMC subpopulations. dmc 91-94 major histocompatibility complex, class I, G Homo sapiens 75-80 33994844-7 2020 We propose the structured iconicity of the ASL verbs primed the semantic features involved in the iconic mapping and these primed semantic features facilitated comprehension of DMC-compliant metaphors and slowed comprehension of DMC-violation metaphors. dmc 177-180 argininosuccinate lyase Homo sapiens 43-46 33994844-7 2020 We propose the structured iconicity of the ASL verbs primed the semantic features involved in the iconic mapping and these primed semantic features facilitated comprehension of DMC-compliant metaphors and slowed comprehension of DMC-violation metaphors. dmc 229-232 argininosuccinate lyase Homo sapiens 43-46 31845005-5 2020 Less positive staining cells for CHST-3, CHST-12, CHST-13, UST, and aggrecan were observed in almost all three zones of PMC and DMC in KBD. dmc 128-131 carbohydrate sulfotransferase 3 Homo sapiens 33-39 31845005-5 2020 Less positive staining cells for CHST-3, CHST-12, CHST-13, UST, and aggrecan were observed in almost all three zones of PMC and DMC in KBD. dmc 128-131 carbohydrate sulfotransferase 12 Homo sapiens 41-48 31845005-5 2020 Less positive staining cells for CHST-3, CHST-12, CHST-13, UST, and aggrecan were observed in almost all three zones of PMC and DMC in KBD. dmc 128-131 carbohydrate sulfotransferase 13 Homo sapiens 50-57 31845005-5 2020 Less positive staining cells for CHST-3, CHST-12, CHST-13, UST, and aggrecan were observed in almost all three zones of PMC and DMC in KBD. dmc 128-131 uronyl 2-sulfotransferase Homo sapiens 59-62 31845005-6 2020 The positive staining cell rates of CHST-12 were higher in superficial and middle zones of PMC and DMC in KBD, and a significantly higher rate of CHST-13 was observed only in superficial zone of PMC in KBD. dmc 99-102 carbohydrate sulfotransferase 12 Homo sapiens 36-43 31999832-7 2020 Nrg-4 was 1.23 (0.02-5.1) ng/mL and 2.5 (0.21-6.01) ng/mL in DMC and in non-DMC groups, respectively (P < .001). dmc 61-64 neuregulin 4 Homo sapiens 0-5 31999832-7 2020 Nrg-4 was 1.23 (0.02-5.1) ng/mL and 2.5 (0.21-6.01) ng/mL in DMC and in non-DMC groups, respectively (P < .001). dmc 76-79 neuregulin 4 Homo sapiens 0-5 31999832-11 2020 Logistic regression analysis showed a 1-unit decrease in Nrg-4 to increase the presence of DMC by 1.9 times. dmc 91-94 neuregulin 4 Homo sapiens 57-62 31999832-12 2020 The best cut-off value of Nrg-4 was 1.56 ng/mL with 82.1% sensitivity and 64% specificity, in predicting DMC. dmc 105-108 neuregulin 4 Homo sapiens 26-31 31999832-13 2020 CONCLUSION: In patients with diabetes, Nrg-4 levels may be a good predictor of early detection of one or more DMC, as microvascular dysfunction in an organ system is considered to be an initial onset of subclinical systemic damage. dmc 110-113 neuregulin 4 Homo sapiens 39-44 31387185-9 2019 The protein expression level of phospho-adenosine monophosphate-activated protein kinase (p-AMPK) (Thr172) in HFD rat livers was lower than that in normal rat livers, whereas it increased in the liver of the DMC-treated rats; however, the protein expression level of total-AMPK in the liver was not different among the groups. dmc 208-211 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 92-96 31493122-1 2019 The aim of present study was to investigate the binding interactions of a model hydrophobic molecule, dimethylcurcumin (DMC) with nanoparticle form of bovine serum albumin (BSA) using fluorescence spectroscopy techniques. dmc 120-123 albumin Homo sapiens 158-171 31387185-15 2019 CONCLUSION: DMC lowered lipids in serum and the liver by activating AMPK. dmc 12-15 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 68-72 31387185-10 2019 The AMPK-activating effect of DMC was blocked by Compound C (a specific AMPK inhibitor) in HepG2 cells. dmc 30-33 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 4-8 31387185-10 2019 The AMPK-activating effect of DMC was blocked by Compound C (a specific AMPK inhibitor) in HepG2 cells. dmc 30-33 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 72-76 31387185-11 2019 Additionally, DMC considerably increased peroxisome proliferator-activated receptor-alpha (PPARalpha) protein expression and lipoprotein lipase (LPL) transcription and concentration in the liver. dmc 14-17 peroxisome proliferator activated receptor alpha Rattus norvegicus 41-89 31387185-11 2019 Additionally, DMC considerably increased peroxisome proliferator-activated receptor-alpha (PPARalpha) protein expression and lipoprotein lipase (LPL) transcription and concentration in the liver. dmc 14-17 peroxisome proliferator activated receptor alpha Homo sapiens 91-100 31387185-11 2019 Additionally, DMC considerably increased peroxisome proliferator-activated receptor-alpha (PPARalpha) protein expression and lipoprotein lipase (LPL) transcription and concentration in the liver. dmc 14-17 lipoprotein lipase Rattus norvegicus 125-143 31387185-11 2019 Additionally, DMC considerably increased peroxisome proliferator-activated receptor-alpha (PPARalpha) protein expression and lipoprotein lipase (LPL) transcription and concentration in the liver. dmc 14-17 lipoprotein lipase Homo sapiens 145-148 31387185-13 2019 DMC also promoted LDL receptor (LDLR) protein expression by activating AMPK. dmc 0-3 low density lipoprotein receptor Rattus norvegicus 18-30 31387185-13 2019 DMC also promoted LDL receptor (LDLR) protein expression by activating AMPK. dmc 0-3 low density lipoprotein receptor Homo sapiens 32-36 31387185-13 2019 DMC also promoted LDL receptor (LDLR) protein expression by activating AMPK. dmc 0-3 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 71-75 31387185-14 2019 We further found that DMC reduced the levels of TC and TG in oleic acid-treated HepG2 cells, and it restored the expression levels of p-AMPK, PPARalpha, LPL, and LDLR compared to the decreased levels observed in oleic acid-treated HepG2 cells. dmc 22-25 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 136-140 31387185-14 2019 We further found that DMC reduced the levels of TC and TG in oleic acid-treated HepG2 cells, and it restored the expression levels of p-AMPK, PPARalpha, LPL, and LDLR compared to the decreased levels observed in oleic acid-treated HepG2 cells. dmc 22-25 peroxisome proliferator activated receptor alpha Homo sapiens 142-151 31387185-14 2019 We further found that DMC reduced the levels of TC and TG in oleic acid-treated HepG2 cells, and it restored the expression levels of p-AMPK, PPARalpha, LPL, and LDLR compared to the decreased levels observed in oleic acid-treated HepG2 cells. dmc 22-25 lipoprotein lipase Homo sapiens 153-156 31387185-14 2019 We further found that DMC reduced the levels of TC and TG in oleic acid-treated HepG2 cells, and it restored the expression levels of p-AMPK, PPARalpha, LPL, and LDLR compared to the decreased levels observed in oleic acid-treated HepG2 cells. dmc 22-25 low density lipoprotein receptor Homo sapiens 162-166 29974839-1 2018 Dimethyl-celecoxib (DMC), a close derivative of celecoxib (CXB) with a low COX-2 inhibitory function, exhibits significant anti-neoplastic properties. dmc 20-23 mitochondrially encoded cytochrome c oxidase II Homo sapiens 75-80 31114793-5 2019 In yeast, DMC reduces the activity of the GATA TF Gln3 and, at the same time, deletion of GLN3 increases autophagy levels during cellular aging per se. dmc 10-13 nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C 50-54 31183037-4 2019 The structure, which crystallizes in the monoclinic space group P21/m, consists of positively charged {Zn2Co(CN)6}+ DMC layers linked through acetate groups and presents a new layered structure to the family of double metal cyanides. dmc 116-119 H3 histone pseudogene 16 Homo sapiens 64-67 31473636-5 2019 Here, we report a case of BRAF-mutated MM who presented with DMC. dmc 61-64 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 26-30 29959755-3 2019 DMC provides a hands-on introduction to the Bayesian implementation of two popular evidence-accumulation models: the diffusion decision model (DDM) and the linear ballistic accumulator (LBA). dmc 0-3 LPS responsive beige-like anchor protein Homo sapiens 156-190 30479543-5 2018 These data suggested that cyclopyrimorate and/or DMC inhibit homogentisate solanesyltransferase (HST), a downstream enzyme of 4-hydroxyphenylpyruvate dioxygenase in the plastoquinone biosynthesis pathway. dmc 49-52 4-hydroxyphenylpyruvate dioxygenase Arabidopsis thaliana 126-161 29974839-5 2018 Both CXB and DMC caused a significant difference in caspase-3 activity compared to the control group. dmc 13-16 caspase 3 Homo sapiens 52-61 29974839-7 2018 Down-regulation of the COX-2 mRNA expression in the celecoxib-treated group was significant compared with that in the DMC-treated group. dmc 118-121 mitochondrially encoded cytochrome c oxidase II Homo sapiens 23-28 29974839-9 2018 Owing to the more potent growth inhibitory effects of DMC compared to that of celecoxib, it may be important to conduct research on the anticancer application of this compound, which can reduce the side effects relating to COX2 inhibition. dmc 54-57 mitochondrially encoded cytochrome c oxidase II Homo sapiens 223-227 28355287-14 2017 We demonstrated that Sirt6 plays a role in tooth root formation and confirmed that SIRT6 is necessary for DMC differentiation as well as for the development of the tooth root and for eventual tooth eruption. dmc 106-109 sirtuin 6 Mus musculus 21-26 28355287-14 2017 We demonstrated that Sirt6 plays a role in tooth root formation and confirmed that SIRT6 is necessary for DMC differentiation as well as for the development of the tooth root and for eventual tooth eruption. dmc 106-109 sirtuin 6 Mus musculus 83-88 27721485-5 2016 DMC markedly restored the decreased secretion of GLP-1 and GIP as well as the coding gene GCG and GIP in ileum. dmc 0-3 glucagon Rattus norvegicus 49-54 27721485-5 2016 DMC markedly restored the decreased secretion of GLP-1 and GIP as well as the coding gene GCG and GIP in ileum. dmc 0-3 gastric inhibitory polypeptide Rattus norvegicus 59-62 27721485-5 2016 DMC markedly restored the decreased secretion of GLP-1 and GIP as well as the coding gene GCG and GIP in ileum. dmc 0-3 glucagon Rattus norvegicus 90-93 27721485-5 2016 DMC markedly restored the decreased secretion of GLP-1 and GIP as well as the coding gene GCG and GIP in ileum. dmc 0-3 gastric inhibitory polypeptide Rattus norvegicus 98-101 27721485-6 2016 Moreover, DMC normalized depressed GCG and GIP transcription by significantly enhancing the GSK-3beta/beta-catenin signaling pathway and expression of TCF7L2, a transactivator of GCG and GIP in diabetic rats. dmc 10-13 glucagon Rattus norvegicus 35-38 27721485-6 2016 Moreover, DMC normalized depressed GCG and GIP transcription by significantly enhancing the GSK-3beta/beta-catenin signaling pathway and expression of TCF7L2, a transactivator of GCG and GIP in diabetic rats. dmc 10-13 gastric inhibitory polypeptide Rattus norvegicus 43-46 27721485-6 2016 Moreover, DMC normalized depressed GCG and GIP transcription by significantly enhancing the GSK-3beta/beta-catenin signaling pathway and expression of TCF7L2, a transactivator of GCG and GIP in diabetic rats. dmc 10-13 glycogen synthase kinase 3 beta Rattus norvegicus 92-101 27721485-6 2016 Moreover, DMC normalized depressed GCG and GIP transcription by significantly enhancing the GSK-3beta/beta-catenin signaling pathway and expression of TCF7L2, a transactivator of GCG and GIP in diabetic rats. dmc 10-13 catenin beta 1 Rattus norvegicus 102-114 27721485-6 2016 Moreover, DMC normalized depressed GCG and GIP transcription by significantly enhancing the GSK-3beta/beta-catenin signaling pathway and expression of TCF7L2, a transactivator of GCG and GIP in diabetic rats. dmc 10-13 transcription factor 7 like 2 Rattus norvegicus 151-157 27721485-6 2016 Moreover, DMC normalized depressed GCG and GIP transcription by significantly enhancing the GSK-3beta/beta-catenin signaling pathway and expression of TCF7L2, a transactivator of GCG and GIP in diabetic rats. dmc 10-13 glucagon Rattus norvegicus 179-182 27721485-6 2016 Moreover, DMC normalized depressed GCG and GIP transcription by significantly enhancing the GSK-3beta/beta-catenin signaling pathway and expression of TCF7L2, a transactivator of GCG and GIP in diabetic rats. dmc 10-13 gastric inhibitory polypeptide Rattus norvegicus 187-190 27721485-7 2016 DMC possesses an anti-hyperglycemic property characterized by preservation/stimulation of GLP-1 and GIP secretion in DM rats. dmc 0-3 glucagon Rattus norvegicus 90-95 27721485-7 2016 DMC possesses an anti-hyperglycemic property characterized by preservation/stimulation of GLP-1 and GIP secretion in DM rats. dmc 0-3 gastric inhibitory polypeptide Rattus norvegicus 100-103 27721485-8 2016 Here, we proposed DMC GSK-3beta/beta-catenin TCF7L2 GLP-1, GIP secretion blood glucose as a regulatory pathway of blood glucose homeostasis. dmc 18-21 glycogen synthase kinase 3 beta Rattus norvegicus 24-33 27721485-8 2016 Here, we proposed DMC GSK-3beta/beta-catenin TCF7L2 GLP-1, GIP secretion blood glucose as a regulatory pathway of blood glucose homeostasis. dmc 18-21 catenin beta 1 Rattus norvegicus 34-46 27721485-8 2016 Here, we proposed DMC GSK-3beta/beta-catenin TCF7L2 GLP-1, GIP secretion blood glucose as a regulatory pathway of blood glucose homeostasis. dmc 18-21 transcription factor 7 like 2 Rattus norvegicus 50-56 27721485-8 2016 Here, we proposed DMC GSK-3beta/beta-catenin TCF7L2 GLP-1, GIP secretion blood glucose as a regulatory pathway of blood glucose homeostasis. dmc 18-21 glucagon Rattus norvegicus 60-65 28118619-7 2016 NADPHd-positive (NADPHd+) neurons in the dorsomedial cortex (DMC; putatively homologous to mammalian CA3) were more numerous and complex than the ones in the medial cortex (MC; putatively homologous to the dentate gyrus). dmc 61-64 carbonic anhydrase 3 Homo sapiens 101-104 28118619-11 2016 In contrast, DCX+ neurons were scarce in the DMC but highly numerous in the MC, particularly in the granular cell layer. dmc 45-48 doublecortin Homo sapiens 13-16