PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 26399372-2 2015 The kinetic mechanisms of action of tyrosinase on monophenols and o-diphenols are complex, particularly in the case of monophenols because of the lag period that occurs at the beginning of the reaction. catechol 66-77 tyrosinase Homo sapiens 36-46 26036788-4 2015 We found that precoating with 3,4-dihydroxy-l-phenylalanine (DOPA) facilitated the immobilization of poly-l-lysine and fibronectin on PLGA substrates via bio-inspired catechol chemistry. catechol 167-175 fibronectin 1 Homo sapiens 119-130 26176355-4 2015 For tyrosinase to act in this way, the Eox form (oxy-tyrosinase) must be present in the reaction medium, which can be brought about by (a) hydrogen peroxide, (b) ascorbic acid, or (c) catalytic concentrations of o-diphenol and a reductant (NADH) to maintain it constant. catechol 212-222 tyrosinase Homo sapiens 4-14 26176355-4 2015 For tyrosinase to act in this way, the Eox form (oxy-tyrosinase) must be present in the reaction medium, which can be brought about by (a) hydrogen peroxide, (b) ascorbic acid, or (c) catalytic concentrations of o-diphenol and a reductant (NADH) to maintain it constant. catechol 212-222 tyrosinase Homo sapiens 53-63 25359714-4 2015 The presence of the catechol group on ring A (6,7-dihydroxy versus 7,8-dihydroxy) correlated with their biological activity, but the reduction of ring C, converting the isoflavones to isoflavans, and the substituent positions on ring B did not affect their potency against 5-LOX. catechol 20-28 arachidonate 5-lipoxygenase Homo sapiens 273-278 25159108-9 2015 Pretreatment of MCF-7 and MCF-10F cells with and inhibitor of catechol-O-methyltransferase (COMT) followed by treatment with E2 or 4-OH E2 caused increased oxidative DNA damage (8-oxo-dG) and depurinating DNA adducts showing the importance of E2-catechol O-methylation by COMT as a protective pathway. catechol 62-70 catechol-O-methyltransferase Homo sapiens 92-96 25159108-9 2015 Pretreatment of MCF-7 and MCF-10F cells with and inhibitor of catechol-O-methyltransferase (COMT) followed by treatment with E2 or 4-OH E2 caused increased oxidative DNA damage (8-oxo-dG) and depurinating DNA adducts showing the importance of E2-catechol O-methylation by COMT as a protective pathway. catechol 62-70 catechol-O-methyltransferase Homo sapiens 272-276 25818422-8 2015 We demonstrated that the gastrointestinal (GI) tract retention of chitosan-catechol was improved compared to unmodified chitosan, which is due to the formation of irreversible catechol mediated-crosslinking with mucin. catechol 75-83 LOC100508689 Homo sapiens 212-217 25818422-8 2015 We demonstrated that the gastrointestinal (GI) tract retention of chitosan-catechol was improved compared to unmodified chitosan, which is due to the formation of irreversible catechol mediated-crosslinking with mucin. catechol 176-184 LOC100508689 Homo sapiens 212-217 26028748-0 2015 Browning inhibition mechanisms by cysteine, ascorbic acid and citric acid, and identifying PPO-catechol-cysteine reaction products. catechol 95-103 protoporphyrinogen oxidase Homo sapiens 91-94 25373500-0 2015 Carbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII). catechol 44-52 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 99-151 25465998-9 2015 The optimum substrate of mPPO was 4-methyl catechol, followed by catechol. catechol 43-51 protoporphyrinogen oxidase Mus musculus 25-29 25500961-1 2015 We proposed a block copolymer, poly(dihydroxystyrene-block-styrene) (PDHSt-b-PSt), that contains catechol groups in the side chains of PDHSt moieties. catechol 97-105 sulfotransferase family 1A member 1 Homo sapiens 77-80 25873687-1 2015 Polyphenol oxidase (PPO) catalyses the oxidation of monophenols and/or o-diphenols to o-quinones with the concomitant reduction of oxygen to water which results in protein complexing and the formation of brown melanin pigments. catechol 71-82 protoporphyrinogen oxidase Homo sapiens 0-18 25873687-1 2015 Polyphenol oxidase (PPO) catalyses the oxidation of monophenols and/or o-diphenols to o-quinones with the concomitant reduction of oxygen to water which results in protein complexing and the formation of brown melanin pigments. catechol 71-82 protoporphyrinogen oxidase Homo sapiens 20-23 32262235-4 2015 The resulting hybrid nonmaterial allowed highly stable aqueous dispersions to be obtained, which were used to coat glassy carbon electrodes for the preparation of a model tyrosinase electrochemical biosensor for catechol. catechol 212-220 tyrosinase Homo sapiens 171-181 25815153-0 2015 Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT). catechol 41-49 catechol-O-methyltransferase Homo sapiens 74-102 25815153-0 2015 Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT). catechol 41-49 catechol-O-methyltransferase Homo sapiens 104-108 26633020-3 2015 The catechol moiety of Cat, Que, and rutin plays an essential role in concerted proton-coupled electron transfer (PCET) to HO2( ) derived from O2( -) to give H2O2 and the corresponding o-benzoquinone radical anions. catechol 4-12 heme oxygenase 2 Homo sapiens 123-126 25383163-7 2014 The absence or presence of the catechol group differentiated the binding affinities and enthalpy/entropy balance between aminoisoflavones and Abeta. catechol 31-39 amyloid beta precursor protein Homo sapiens 142-147 25563188-6 2015 DMR profiling using catechol as a conformational probe detects the presence of multiple conformations of the beta2AR. catechol 20-28 adrenoceptor beta 2 Homo sapiens 109-116 25856712-8 2015 Unaffected by other compounds, fMLP-dependent increase of [Ca(2+)]i was inhibited by quercetin and catechol (5 microM) by 32 +- 14 and 12 +- 10% (p < 0.04), respectively. catechol 99-107 formyl peptide receptor 1 Homo sapiens 31-35 25856712-10 2015 Catechol, quercetin, and gallic acid acted most potently reducing fMLP-LBCL by 49 +- 5, 42 +- 15, and 28 +- 18% (p < 0.05), respectively. catechol 0-8 formyl peptide receptor 1 Homo sapiens 66-70 26257890-9 2015 Although catechol was a known NGAL-Siderocalin co-factor, our purification directly confirmed its presence in urine as well as its capacity to serve as an iron trap with NGAL-Siderocalin. catechol 9-17 lipocalin 2 Homo sapiens 30-34 26257890-9 2015 Although catechol was a known NGAL-Siderocalin co-factor, our purification directly confirmed its presence in urine as well as its capacity to serve as an iron trap with NGAL-Siderocalin. catechol 9-17 lipocalin 2 Homo sapiens 170-174 25383163-8 2014 Furthermore, having a catechol group influenced the binding mode with fibrillar Abeta. catechol 22-30 amyloid beta precursor protein Homo sapiens 80-85 25771868-9 2014 These results suggest that in addition to activating benzene and phenol, human CYP2E1 may further convert hydroquinone, catechol and trihydroxybenzene to more genotoxic metabolites, and sulfo-conjugation of the multi-hydroxylated metabolites of benzene by human SULT1A1 may represent an important detoxifying pathway. catechol 120-128 sulfotransferase family 1A member 1 Homo sapiens 262-269 23776099-9 2014 Consistently, an increase in expression level of sialidase Neu3 mRNA and a decrease in mRNA level of sialyltransferase ST3GAL3 gene were detected in hydroquione-, catechol-, or 1,2,4-benzenetriol-treated cells, but no change in mRNA levels of two genes were found in phenol-treated cells. catechol 163-171 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 Homo sapiens 119-126 25771868-7 2014 Moreover, inhibition of SULT1A1 by pentachlorophenol potentiated the effects of benzene, hydroquinone, catechol and trihydroxybenzene. catechol 103-111 sulfotransferase family 1A member 1 Homo sapiens 24-31 25771868-9 2014 These results suggest that in addition to activating benzene and phenol, human CYP2E1 may further convert hydroquinone, catechol and trihydroxybenzene to more genotoxic metabolites, and sulfo-conjugation of the multi-hydroxylated metabolites of benzene by human SULT1A1 may represent an important detoxifying pathway. catechol 120-128 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 79-85 26257890-0 2015 Purification and Structural Characterization of "Simple Catechol", the NGAL-Siderocalin Siderophore in Human Urine. catechol 56-64 lipocalin 2 Homo sapiens 71-75 25066316-8 2014 Cortisone or catechol caused moderate inhibition of Kvbeta2 turnover, and the aldo-keto reductases inhibitor valproate had an even smaller effect. catechol 13-21 potassium voltage-gated channel subfamily A regulatory beta subunit 2 Homo sapiens 52-59 25429411-0 2014 The simultaneous electrochemical detection of catechol and hydroquinone with [Cu(Sal-beta-Ala)(3,5-DMPz)2]/SWCNTs/GCE. catechol 46-54 aminomethyltransferase Homo sapiens 114-117 24874658-0 2014 Amperometric detection of catechol using tyrosinase modified electrodes enhanced by the layer-by-layer assembly of gold nanocubes and polyelectrolytes. catechol 26-34 tyrosinase Homo sapiens 41-51 24874658-1 2014 A novel amperometric biosensor for catechol was developed using the layer-by-layer (LbL) self-assembly of positively charged hexadecyltrimethylammonium stabilized gold nanocubes (AuNCs), negatively charged poly(sodium 4-styrenesulfonate) and tyrosinase on a screen printed carbon electrode (SPCE). catechol 35-43 tyrosinase Homo sapiens 242-252 25084335-1 2014 Methylation catalysed by catechol-O-methyltransferase (COMT) is the main pathway of catechol neurotransmitter deactivation in the prefrontal cortex. catechol 25-33 catechol-O-methyltransferase Homo sapiens 55-59 24704693-1 2014 Tyrosinase is a copper-containing enzyme that mediates the hydroxylation of monophenols and oxidation of o-diphenols to o-quinones. catechol 105-116 tyrosinase Crassostrea gigas 0-10 24832624-7 2014 Catechol-modified UCH-L1 as well as insoluble UCH-L1 were detected in the midbrain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated PD model mice. catechol 0-8 ubiquitin carboxy-terminal hydrolase L1 Mus musculus 18-24 24874658-3 2014 Each SPCE sensor surface was terminated with tyrosinase and the electrocatalytic response due to the tyrosinase reaction with catechol was measured using cyclic voltammetry and square wave voltammetry (SWV). catechol 126-134 tyrosinase Homo sapiens 101-111 24951922-3 2014 Under optimal conditions, GCE/MCN/Tyr biosensor was evaluated by chronoamperometry measurements and the reduction current of phenol and catechol was proportional to their concentration in the range of 5.00 x 10(-8)-9.50 x 10(-6)M and 5.00 x 10(-8)-1.25 x 10(-5)M with a correlation coefficient of 0.9991 and 0.9881, respectively. catechol 136-144 aminomethyltransferase Homo sapiens 26-29 24916123-6 2014 In the present study we show that oxidation of the catechol moiety of epicatechins to an omicron-quinone by MPO generates potent MIF inhibitors. catechol 51-59 myeloperoxidase Homo sapiens 108-111 24916123-6 2014 In the present study we show that oxidation of the catechol moiety of epicatechins to an omicron-quinone by MPO generates potent MIF inhibitors. catechol 51-59 macrophage migration inhibitory factor Homo sapiens 129-132 25122505-0 2014 Antiplatelet effect of catechol is related to inhibition of cyclooxygenase, reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. catechol 23-31 mitogen-activated protein kinase 1 Homo sapiens 101-104 25122505-0 2014 Antiplatelet effect of catechol is related to inhibition of cyclooxygenase, reactive oxygen species, ERK/p38 signaling and thromboxane A2 production. catechol 23-31 mitogen-activated protein kinase 1 Homo sapiens 105-108 24909769-3 2014 The tyrosinase/SPC(TTF)E response to pyrocatechol is inhibited by Cr(III). catechol 37-49 tyrosinase Homo sapiens 4-14 24909769-3 2014 The tyrosinase/SPC(TTF)E response to pyrocatechol is inhibited by Cr(III). catechol 37-49 proline rich protein gene cluster Homo sapiens 15-18 24715002-4 2014 UV spectra of H4L in the absence and presence of different metal ions indicate complexes formed with the catechol moiety of H4L in aqueous solution. catechol 105-113 H4 clustered histone 7 Homo sapiens 14-17 24798325-5 2014 We demonstrate that similar to lipocalin 2, Bet v 1 is capable of binding iron via catechol-based siderophores. catechol 83-91 lipocalin 2 Homo sapiens 31-42 24798325-5 2014 We demonstrate that similar to lipocalin 2, Bet v 1 is capable of binding iron via catechol-based siderophores. catechol 83-91 delta/notch like EGF repeat containing Homo sapiens 44-47 24715002-4 2014 UV spectra of H4L in the absence and presence of different metal ions indicate complexes formed with the catechol moiety of H4L in aqueous solution. catechol 105-113 H4 clustered histone 7 Homo sapiens 124-127 24767847-2 2014 Oxidation of phenols by native tyrosinase requires activation by in situ formation of a catechol formed via an enzyme generated ortho-quinone. catechol 88-96 tyrosinase Homo sapiens 31-41 24769391-3 2014 The electrochemical behaviors of pyrocatechol (PC) and hydroquinone (HQ) were investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at the PBL-II/CPE in pH 7.0 phosphate buffer solution (PBS). catechol 33-45 carboxypeptidase E Homo sapiens 166-176 24769391-3 2014 The electrochemical behaviors of pyrocatechol (PC) and hydroquinone (HQ) were investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at the PBL-II/CPE in pH 7.0 phosphate buffer solution (PBS). catechol 47-49 carboxypeptidase E Homo sapiens 166-176 25087634-2 2014 Among the synthesized compounds, compounds 15 and 20, which contain a catechol moiety, showed both potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity (15: EC50=17 microM; 20: EC50=23 microM) and alpha-glucosidase inhibitory activity (15: IC50=16 microM; 20: IC50=10 microM). catechol 70-78 sucrase-isomaltase Homo sapiens 221-238 32261711-4 2014 The designed biosensor with synergic properties between the high conductivity of iridium oxide nanoparticles, low-cost screen printed electrodes and the efficiency of tyrosinase shows broad linearity ranges for catechol and chlorpyrifos detection. catechol 211-219 tyrosinase Homo sapiens 167-177 32261711-5 2014 Using this biosensor, very low limits of detection for catechol (0.08 muM) and chlorpyrifos (0.003 muM) are observed and recoveries of spiked tap and river water samples have also been studied showing very good recoveries. catechol 55-63 latexin Homo sapiens 70-73 24656803-7 2014 Initially the conversion of met- to deoxy-tyrosinase is brought about by a catechol that is indirectly formed from an ortho-quinone product of tyrosinase action. catechol 75-83 tyrosinase Homo sapiens 42-52 24656803-7 2014 Initially the conversion of met- to deoxy-tyrosinase is brought about by a catechol that is indirectly formed from an ortho-quinone product of tyrosinase action. catechol 75-83 tyrosinase Homo sapiens 143-153 24847525-2 2014 Catechol ligands are chemically attached to the interior surface of P22 viral capsid for subsequent encapsulation of an anticancer drug, bortezomib (BTZ), through boronic acid-diol complexation. catechol 0-8 calcineurin like EF-hand protein 1 Homo sapiens 68-71 24651612-0 2014 Laccase immobilized on a PAN/adsorbents composite nanofibrous membrane for catechol treatment by a biocatalysis/adsorption process. catechol 75-83 adenosine deaminase 2 Homo sapiens 25-28 24651612-1 2014 The treatment of catechol via biocatalysis and adsorption with a commercial laccase immobilized on polyacrylonitrile/montmorillonite/graphene oxide (PAN/MMT/GO) composite nanofibers was evaluated with a homemade nanofibrous membrane reactor. catechol 17-25 adenosine deaminase 2 Homo sapiens 149-152 24651612-9 2014 Experimental results suggested that laccase, PAN, adsorbent nanoparticles (MMT/GO) can be combined together for catechol treatment in industrial applications. catechol 112-120 adenosine deaminase 2 Homo sapiens 45-48 25122505-7 2014 Catechol (10-50 microM) suppressed COX-1 activity by 29-44% and COX-2 activity by 29-50%. catechol 0-8 mitochondrially encoded cytochrome c oxidase I Homo sapiens 35-40 25122505-7 2014 Catechol (10-50 microM) suppressed COX-1 activity by 29-44% and COX-2 activity by 29-50%. catechol 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 64-69 25122505-10 2014 Exposure of platelets to catechol decreased AA-induced ERK and p38 phosphorylation. catechol 25-33 mitogen-activated protein kinase 1 Homo sapiens 55-58 25122505-10 2014 Exposure of platelets to catechol decreased AA-induced ERK and p38 phosphorylation. catechol 25-33 mitogen-activated protein kinase 1 Homo sapiens 63-66 25122505-12 2014 These results suggest that catechol exhibited anti-platelet and anti-inflammatory effects, which were mediated by inhibition of COX, ROS and TXA2 production as well as ERK/p38 phosphorylation. catechol 27-35 mitogen-activated protein kinase 1 Homo sapiens 168-171 25122505-12 2014 These results suggest that catechol exhibited anti-platelet and anti-inflammatory effects, which were mediated by inhibition of COX, ROS and TXA2 production as well as ERK/p38 phosphorylation. catechol 27-35 mitogen-activated protein kinase 1 Homo sapiens 172-175 24851249-6 2014 Catechol-terminated SAMs are also obtained on high-roughness gold substrates that show the ability to assemble magnetic nanoparticles, despite their lack of enhanced adhesion at the molecular level. catechol 0-8 methionine adenosyltransferase 1A Homo sapiens 20-24 24853564-1 2014 Tyrosinase is a multifunctional copper-containing enzyme widely distributed in plants and animals, which catalyzes both the hydroxylation of tyrosine into o-diphenols and the oxidation of o-diphenols into o-quinones. catechol 155-166 tyrosinase Homo sapiens 0-10 24853564-1 2014 Tyrosinase is a multifunctional copper-containing enzyme widely distributed in plants and animals, which catalyzes both the hydroxylation of tyrosine into o-diphenols and the oxidation of o-diphenols into o-quinones. catechol 188-199 tyrosinase Homo sapiens 0-10 24144187-3 2013 Herein, the interaction of Ngb with the quinones generated by oxidation of catecholamines (dopamine, norepinephrine) and catechol estrogens (2-hydroxyestradiol and 4-hydroxyestradiol), which have been implicated in neurodegenerative pathologies like Parkinson"s and Alzheimer"s diseases, has been investigated. catechol 75-83 neuroglobin Homo sapiens 27-30 24144187-5 2013 Combined studies of tandem mass spectrometry and protein unfolding indicate the presence of quinone-promoted modifications in all of the Ngb derivatives analyzed (i.e., obtained employing either catecholamines or catechol estrogens as the source of the reactive species). catechol 195-203 neuroglobin Homo sapiens 137-140 24144187-6 2013 Among protein residues, the highest reactivity of cysteines (Cys46, Cys55, and Cys120 in human Ngb) toward quinone species has been confirmed, and the dependence of the extent of protein modification on the method employed for catechol oxidation has been observed. catechol 227-235 neuroglobin Homo sapiens 95-98 24141029-4 2013 Catechol is a substrate for the catechol-O-methyltransferase (COMT)-mediated methylation. catechol 0-8 catechol-O-methyltransferase Homo sapiens 32-60 24216089-1 2013 Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required in traditional procedures. catechol 0-8 tyrosinase Homo sapiens 85-95 24141029-4 2013 Catechol is a substrate for the catechol-O-methyltransferase (COMT)-mediated methylation. catechol 0-8 catechol-O-methyltransferase Homo sapiens 62-66 24141029-5 2013 In the present study, the role of COMT in catechol-enhanced erythroid differentiation of K562 cells was investigated. catechol 42-50 catechol-O-methyltransferase Homo sapiens 34-38 24141029-8 2013 When COMT expression was knocked down by COMT shRNA expression in K562 cells, the production of guaiacol significantly reduced, and the sensitivity of K562 cells to cytotoxicity of catechol significantly increased. catechol 181-189 catechol-O-methyltransferase Homo sapiens 5-9 24141029-8 2013 When COMT expression was knocked down by COMT shRNA expression in K562 cells, the production of guaiacol significantly reduced, and the sensitivity of K562 cells to cytotoxicity of catechol significantly increased. catechol 181-189 catechol-O-methyltransferase Homo sapiens 41-45 24141029-9 2013 Knockdown of COMT expression by COMT shRNA expression also eliminated catechol-enhanced erythroid differentiation of K562 cells. catechol 70-78 catechol-O-methyltransferase Homo sapiens 13-17 24141029-9 2013 Knockdown of COMT expression by COMT shRNA expression also eliminated catechol-enhanced erythroid differentiation of K562 cells. catechol 70-78 catechol-O-methyltransferase Homo sapiens 32-36 24141029-11 2013 These findings indicated that O-methylation catalyzed by COMT acted as detoxication of catechol and involved in catechol-enhanced erythroid differentiation of K562 cells, and the production of S-adenosyl-L-homocysteine partly explained catechol-enhanced erythroid differentiation. catechol 87-95 catechol-O-methyltransferase Homo sapiens 57-61 24141029-11 2013 These findings indicated that O-methylation catalyzed by COMT acted as detoxication of catechol and involved in catechol-enhanced erythroid differentiation of K562 cells, and the production of S-adenosyl-L-homocysteine partly explained catechol-enhanced erythroid differentiation. catechol 112-120 catechol-O-methyltransferase Homo sapiens 57-61 24141029-11 2013 These findings indicated that O-methylation catalyzed by COMT acted as detoxication of catechol and involved in catechol-enhanced erythroid differentiation of K562 cells, and the production of S-adenosyl-L-homocysteine partly explained catechol-enhanced erythroid differentiation. catechol 112-120 catechol-O-methyltransferase Homo sapiens 57-61 24390993-1 2013 Catechol-O-methyltransferase (COMT) is a critical enzyme to detoxify the carcinogenic catechol estrogen and the Val158Met polymorphism of COMT could influence its enzymatic activity. catechol 86-94 catechol-O-methyltransferase Homo sapiens 0-28 24390993-1 2013 Catechol-O-methyltransferase (COMT) is a critical enzyme to detoxify the carcinogenic catechol estrogen and the Val158Met polymorphism of COMT could influence its enzymatic activity. catechol 86-94 catechol-O-methyltransferase Homo sapiens 30-34 24390993-1 2013 Catechol-O-methyltransferase (COMT) is a critical enzyme to detoxify the carcinogenic catechol estrogen and the Val158Met polymorphism of COMT could influence its enzymatic activity. catechol 86-94 catechol-O-methyltransferase Homo sapiens 138-142 23892357-6 2013 Sodium hypochlorite (NaOCl) oxidation of the catechol moiety in CAPE produced an oxidized, electrophilic form of CAPE (Oxi-CAPE) and greatly enhanced the ability of CAPE to activate Nrf2 and to bind to Keap1. catechol 45-53 structural maintenance of chromosomes 2 Rattus norvegicus 64-68 25478881-4 2014 The literature reports suggest that the double bond, a carbonyl group of chromone and 3 ,4 -dihydroxy group (catechol) in ring B along with the C-3 and C-5 hydroxyl groups are important for radical scavenging activity. catechol 109-117 complement C3 Homo sapiens 144-155 23892357-6 2013 Sodium hypochlorite (NaOCl) oxidation of the catechol moiety in CAPE produced an oxidized, electrophilic form of CAPE (Oxi-CAPE) and greatly enhanced the ability of CAPE to activate Nrf2 and to bind to Keap1. catechol 45-53 structural maintenance of chromosomes 2 Rattus norvegicus 113-117 23892357-6 2013 Sodium hypochlorite (NaOCl) oxidation of the catechol moiety in CAPE produced an oxidized, electrophilic form of CAPE (Oxi-CAPE) and greatly enhanced the ability of CAPE to activate Nrf2 and to bind to Keap1. catechol 45-53 structural maintenance of chromosomes 2 Rattus norvegicus 113-117 23892357-6 2013 Sodium hypochlorite (NaOCl) oxidation of the catechol moiety in CAPE produced an oxidized, electrophilic form of CAPE (Oxi-CAPE) and greatly enhanced the ability of CAPE to activate Nrf2 and to bind to Keap1. catechol 45-53 structural maintenance of chromosomes 2 Rattus norvegicus 113-117 23892357-6 2013 Sodium hypochlorite (NaOCl) oxidation of the catechol moiety in CAPE produced an oxidized, electrophilic form of CAPE (Oxi-CAPE) and greatly enhanced the ability of CAPE to activate Nrf2 and to bind to Keap1. catechol 45-53 NFE2 like bZIP transcription factor 2 Rattus norvegicus 182-186 23892357-6 2013 Sodium hypochlorite (NaOCl) oxidation of the catechol moiety in CAPE produced an oxidized, electrophilic form of CAPE (Oxi-CAPE) and greatly enhanced the ability of CAPE to activate Nrf2 and to bind to Keap1. catechol 45-53 Kelch-like ECH-associated protein 1 Rattus norvegicus 202-207 23892357-9 2013 Our data suggest that CAPE requires the catechol moiety for the oxidation-enhanced activation of the Nrf2 pathway and has potential as a pathologically targeted Nrf2-activating agent that is exclusively activated in pathological states with oxidative stress such as colonic inflammation. catechol 40-48 structural maintenance of chromosomes 2 Rattus norvegicus 22-26 23892357-9 2013 Our data suggest that CAPE requires the catechol moiety for the oxidation-enhanced activation of the Nrf2 pathway and has potential as a pathologically targeted Nrf2-activating agent that is exclusively activated in pathological states with oxidative stress such as colonic inflammation. catechol 40-48 NFE2 like bZIP transcription factor 2 Rattus norvegicus 101-105 23928335-12 2013 Furthermore, incubation of catechol estrogens with myeloperoxidase (MPO) in the presence of HCys resulted in the formation of respective estrogen-HCys conjugates. catechol 27-35 myeloperoxidase Homo sapiens 51-66 23928335-12 2013 Furthermore, incubation of catechol estrogens with myeloperoxidase (MPO) in the presence of HCys resulted in the formation of respective estrogen-HCys conjugates. catechol 27-35 myeloperoxidase Homo sapiens 68-71 23843041-2 2013 NQO1 reduces the carcinogenic estrogen metabolite, catechol estrogen-3,4-quinone, whereas GSTs detoxify it through conjugation with glutathione. catechol 51-59 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 23941596-6 2013 Our study demonstrates that predeposition of a pDA layer facilitates highly efficient, simple immobilization of peptides derived from osteogenic growth factor (bone morphogenetic protein-2; BMP-2) on poly(lactic-co-glycolic acid) (PLGA) scaffolds via catechol chemistry. catechol 251-259 bone morphogenetic protein 2 Homo sapiens 160-188 23892357-4 2013 CAPE and the CAPE analogue with a catechol moiety, but not the other analogues, activated the Nrf2 pathway. catechol 34-42 structural maintenance of chromosomes 2 Rattus norvegicus 13-17 23892357-4 2013 CAPE and the CAPE analogue with a catechol moiety, but not the other analogues, activated the Nrf2 pathway. catechol 34-42 NFE2 like bZIP transcription factor 2 Rattus norvegicus 94-98 23892357-5 2013 In addition, only biotin-labeled CAPE analogues with the catechol moiety precipitated Kelch-like ECH associated protein 1 (Keap1) when incubated with cell lysates and streptavidin agarose beads. catechol 57-65 structural maintenance of chromosomes 2 Rattus norvegicus 33-37 23892357-5 2013 In addition, only biotin-labeled CAPE analogues with the catechol moiety precipitated Kelch-like ECH associated protein 1 (Keap1) when incubated with cell lysates and streptavidin agarose beads. catechol 57-65 Kelch-like ECH-associated protein 1 Rattus norvegicus 86-121 23892357-5 2013 In addition, only biotin-labeled CAPE analogues with the catechol moiety precipitated Kelch-like ECH associated protein 1 (Keap1) when incubated with cell lysates and streptavidin agarose beads. catechol 57-65 Kelch-like ECH-associated protein 1 Rattus norvegicus 123-128 23727196-0 2013 Catechol-functionalized adhesive polymer nanoparticles for controlled local release of bone morphogenetic protein-2 from titanium surface. catechol 0-8 bone morphogenetic protein 2 Homo sapiens 87-115 23941596-6 2013 Our study demonstrates that predeposition of a pDA layer facilitates highly efficient, simple immobilization of peptides derived from osteogenic growth factor (bone morphogenetic protein-2; BMP-2) on poly(lactic-co-glycolic acid) (PLGA) scaffolds via catechol chemistry. catechol 251-259 bone morphogenetic protein 2 Homo sapiens 190-195 22729568-12 2013 The high levels of PCB with estrogenic activity found in our cases, could promote lung cancer inducing cell proliferation in non-neoplastic and neoplastic lung cells via ERbeta; inducing the formation of DNA adducts, producing oxidative stress with the subsequent DNA damage and increasing the endogenous catechol levels by catechol-O-methyl transferase (COMT) inhibition. catechol 305-313 pyruvate carboxylase Homo sapiens 19-22 23893774-0 2013 Deuterium isotope effect on the suicide inactivation of tyrosinase in its action on o-diphenols. catechol 84-95 tyrosinase Homo sapiens 56-66 23893774-1 2013 A solvent deuterium isotope effect on the inactivation suicide of tyrosinase in its action on o-diphenols (catechol, 4-methylcatechol, and 4-tert-butylcatechol) was observed. catechol 94-105 tyrosinase Homo sapiens 66-76 23893774-1 2013 A solvent deuterium isotope effect on the inactivation suicide of tyrosinase in its action on o-diphenols (catechol, 4-methylcatechol, and 4-tert-butylcatechol) was observed. catechol 107-115 tyrosinase Homo sapiens 66-76 24018130-3 2013 The selective binding of Fe(III)-catechol ligands to NGAL is here studied by using iron coordination structures with one, two, and three catecholate ligands. catechol 33-41 lipocalin 2 Homo sapiens 53-57 23905650-8 2013 The 4-methylcoumarin derivatives bearing the catechol group suppressed the elastase and myeloperoxidase activity and reduced the 1,1-diphenyl-2-picrylhydrazyl free radical the most strongly. catechol 45-53 myeloperoxidase Homo sapiens 75-103 23558779-5 2013 The catechol metabolites of ZEN were also shown to inhibit the O-methylation of 2-hydroxy-E2 by hepatic COMT from mouse, rat, steer and piglet, although to a lesser extent than observed with human COMT. catechol 4-12 catechol-O-methyltransferase Homo sapiens 197-201 23558779-6 2013 The powerful inhibitory effect of catechol metabolites of ZEN on COMT may have implications for the tumorigenic activity of E2, because catechol metabolites of E2 elicit genotoxic effects, and their impaired O-methylation may increase the tumorigenicity of steroidal estrogens. catechol 34-42 catechol-O-methyltransferase Homo sapiens 65-69 23558779-0 2013 Catechol metabolites of the mycotoxin zearalenone are poor substrates but potent inhibitors of catechol-O-methyltransferase. catechol 0-8 catechol-O-methyltransferase Homo sapiens 95-123 23558779-2 2013 Previous studies have shown that the catechol metabolites of ZEN have about the same potency to induce oxidative DNA damage as the catechol metabolites of E2, but are less efficiently converted to their methyl ethers by human hepatic catechol-O-methyltransferase (COMT). catechol 37-45 catechol-O-methyltransferase Homo sapiens 234-262 23558779-6 2013 The powerful inhibitory effect of catechol metabolites of ZEN on COMT may have implications for the tumorigenic activity of E2, because catechol metabolites of E2 elicit genotoxic effects, and their impaired O-methylation may increase the tumorigenicity of steroidal estrogens. catechol 136-144 catechol-O-methyltransferase Homo sapiens 65-69 23558779-2 2013 Previous studies have shown that the catechol metabolites of ZEN have about the same potency to induce oxidative DNA damage as the catechol metabolites of E2, but are less efficiently converted to their methyl ethers by human hepatic catechol-O-methyltransferase (COMT). catechol 37-45 catechol-O-methyltransferase Homo sapiens 264-268 23558779-3 2013 Here, we report that the two catechol metabolites of ZEN, i.e. 13-hydroxy-ZEN and 15-hydroxy-ZEN, are not only poor substrates of human COMT but are also able to strongly inhibit the O-methylation of 2-hydroxy-E2, the major catechol metabolite of E2. catechol 29-37 catechol-O-methyltransferase Homo sapiens 136-140 23558779-5 2013 The catechol metabolites of ZEN were also shown to inhibit the O-methylation of 2-hydroxy-E2 by hepatic COMT from mouse, rat, steer and piglet, although to a lesser extent than observed with human COMT. catechol 4-12 catechol-O-methyltransferase Mus musculus 104-108 23695836-9 2013 Further, under anoxic growth conditions strain CAB utilized the biogenic oxygen produced as a result of chlorite dismutation to oxidize catechol via the meta-cleavage pathway of aerobic catechol degradation and the catechol 2,3-dioxygenase enzyme. catechol 136-144 neural proliferation, differentiation and control 1 Homo sapiens 47-50 23683835-7 2013 Structure-activity relationship studies suggested that introduction of an NO donor, protection of the catechol structure, and the ether chain of a 2-carbon spacer as a coupling chain on the luteolin scaffold all help increase the AR inhibitory activity of the resulting compound. catechol 102-110 aldo-keto reductase family 1 member B Homo sapiens 230-232 23695836-9 2013 Further, under anoxic growth conditions strain CAB utilized the biogenic oxygen produced as a result of chlorite dismutation to oxidize catechol via the meta-cleavage pathway of aerobic catechol degradation and the catechol 2,3-dioxygenase enzyme. catechol 186-194 neural proliferation, differentiation and control 1 Homo sapiens 47-50 23695836-9 2013 Further, under anoxic growth conditions strain CAB utilized the biogenic oxygen produced as a result of chlorite dismutation to oxidize catechol via the meta-cleavage pathway of aerobic catechol degradation and the catechol 2,3-dioxygenase enzyme. catechol 186-194 neural proliferation, differentiation and control 1 Homo sapiens 47-50 23695836-17 2013 The ability of strain CAB to oxidize catechol via the oxygenase-dependent meta-cleavage pathway in the absence of external oxygen by using the biogenic oxygen produced from the dismutation of chlorite provides a valuable model for understanding the anaerobic degradation of a broad diversity of xenobiotics which are recalcitrant to anaerobic metabolism but labile to oxygenase-dependent mechanisms. catechol 37-45 neural proliferation, differentiation and control 1 Homo sapiens 22-25 32260882-5 2013 This bioelectrode showed excellent electroanalytical behavior for catechol with a fast response in about 6 s, linear range of 10 nM to 22 muM, sensitivity of 424 mA M-1, and low detection limit of 6 nM. catechol 66-74 latexin Homo sapiens 138-141 23352755-1 2013 The inactivation of tyrosinase by resorcinol (1,3-dihydroxybenzene) and seventeen simple derivatives has been investigated using combined spectrophotometry and oximetry together with hplc/ms examination of the oxidation products. catechol 46-66 tyrosinase Homo sapiens 20-30 24276120-0 2013 The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists. catechol 10-18 G protein-coupled receptor 35 Homo sapiens 63-68 24276120-2 2013 Using label-free dynamic mass redistribution and Tango beta-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin and fenoldopam, display agonistic activity against GPR35. catechol 112-120 G protein-coupled receptor 35 Homo sapiens 254-259 23468244-3 2013 The NQO1 was shown to act as a p53 stabilizer and was suggested to play an important role in the protection against carcinogenic catechol estrogens. catechol 129-137 NAD(P)H quinone dehydrogenase 1 Homo sapiens 4-8 23468244-3 2013 The NQO1 was shown to act as a p53 stabilizer and was suggested to play an important role in the protection against carcinogenic catechol estrogens. catechol 129-137 tumor protein p53 Homo sapiens 31-34 23352755-2 2013 The results are consistent with a Quintox mechanism, analogous to that proposed for catechol inactivation of tyrosinase, in which the resorcinol substrate is oxidised via the monooxygenase route leading to a hydroxy intermediate that undergoes deprotonation and results in irreversible elimination of Cu(0) from the active site. catechol 84-92 tyrosinase Homo sapiens 109-119 23311874-10 2013 The catechol and/or galloyl groups appear to be important structural determinants that mediate the interaction of these polyphenolic compounds with TAS2R5. catechol 4-12 taste 2 receptor member 5 Homo sapiens 148-154 23574677-1 2013 An amperometric biosensor for the determination of catechol was developed by immobilizing tyrosinase (tyr) on gold nanoparticles (AuNPs) and a (3-mercaptopropyl)-trimethoxysilane (MPTS) sol-gel three-dimensional network film-modified gold electrode. catechol 51-59 tyrosinase Homo sapiens 90-100 22809524-5 2013 BiNPs/Tyr biosensor is evaluated by amperometric measurements at -200 mV DC and a linear range of up to 71 muM and 100 muM and a correlation coefficient of 0.995 and 0.996 for phenol and catechol, respectively. catechol 187-195 tyrosinase Homo sapiens 6-9 23228886-0 2013 Oxidative modification of neurofilament-L and neuronal cell death induced by the catechol neurotoxin, tetrahydropapaveroline. catechol 81-89 neurofilament light chain Homo sapiens 26-41 23270545-3 2013 The enhanced RTP intensity of 1 muM catechol was not affected by the coexistence of 30 muM resorcinol and 50 muM hydroquinone at pH 8.0. catechol 36-44 latexin Homo sapiens 32-35 23270545-4 2013 The detection limit of this RTP method was 53 nM catechol, and the precision was 3.2% (relative standard deviation) for five replicate detections of 1 muM catechol. catechol 155-163 latexin Homo sapiens 151-154 23194825-5 2013 MDMA catechol metabolites were neurotoxic to SH-SY5Y neurons, leading to caspase 3-independent cell death in a concentration- and time-dependent manner. catechol 5-13 caspase 3 Homo sapiens 73-82 23433116-0 2013 Salsolinol, a catechol neurotoxin, induces oxidative modification of cytochrome c. catechol 14-22 cytochrome c, somatic Homo sapiens 69-81 23142567-6 2013 Notably, the interaction between Lys55, Asp169, and Glu73 of JNK1 and the catechol moiety of quercetagetin reorients the N-terminal lobe of JNK1, thereby improving compatibility of the ligand with its binding site. catechol 74-82 mitogen-activated protein kinase 8 Mus musculus 140-144 23142567-7 2013 The results of a theoretical docking study suggest a binding mode of PI3-K with the hydroxyl groups of the catechol moiety forming hydrogen bonds with the side chains of Asp964 and Asp841 in the p110gamma catalytic subunit. catechol 107-115 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 195-204 23261967-6 2013 Structural analysis using derivatives of PCT revealed that the catechol moiety in PCT was required for the stabilization of HIF-1alpha protein. catechol 63-71 hypoxia inducible factor 1 subunit alpha Homo sapiens 124-134 23022512-9 2012 The exposure to catechol caused a decrease in DNA methylation levels at a few CpG sites in some erythroid specific genes including alpha-globin, beta-globin and erythroid porphobilinogen deaminase genes. catechol 16-24 hemoglobin subunit alpha 2 Homo sapiens 131-143 22124994-1 2013 BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catechol estrogens by methylation and thus may play a protective role against mutations induced by estrogen metabolites. catechol 60-68 catechol-O-methyltransferase Homo sapiens 12-40 22124994-1 2013 BACKGROUND: Catechol-O-methyltransferase (COMT) inactivates catechol estrogens by methylation and thus may play a protective role against mutations induced by estrogen metabolites. catechol 60-68 catechol-O-methyltransferase Homo sapiens 42-46 23022512-9 2012 The exposure to catechol caused a decrease in DNA methylation levels at a few CpG sites in some erythroid specific genes including alpha-globin, beta-globin and erythroid porphobilinogen deaminase genes. catechol 16-24 hemoglobin subunit beta Homo sapiens 145-156 23022512-9 2012 The exposure to catechol caused a decrease in DNA methylation levels at a few CpG sites in some erythroid specific genes including alpha-globin, beta-globin and erythroid porphobilinogen deaminase genes. catechol 16-24 hydroxymethylbilane synthase Homo sapiens 171-196 23606198-13 2012 Thus, the catechol metabolites of the mycoestrogen ZEN and its reductive metabolite alpha-ZEL exhibit a DNA-damaging potential comparable to that of the catechol metabolites of E1 and E2, but are much poorer substrates for inactivation by human COMT. catechol 10-18 catechol-O-methyltransferase Homo sapiens 245-249 21397529-1 2012 OBJECTIVES: To examine associations between urinary bladder cancer risk and polymorphisms of the gene encoding the catechol estrogen-metabolizing enzyme, catechol-O-methyltransferase (COMT), among Egyptian women and men. catechol 115-123 catechol-O-methyltransferase Homo sapiens 154-182 21397529-1 2012 OBJECTIVES: To examine associations between urinary bladder cancer risk and polymorphisms of the gene encoding the catechol estrogen-metabolizing enzyme, catechol-O-methyltransferase (COMT), among Egyptian women and men. catechol 115-123 catechol-O-methyltransferase Homo sapiens 184-188 22946879-6 2012 The aptamer competes with a catechol iron-siderophore, the natural ligand of mLcn2. catechol 28-36 lipocalin 2 Mus musculus 77-82 22984948-1 2012 Structure-activity relationship study shows that the catechol group in 7,8-dihdyroxyflavone, a selective small TrkB receptor agonist, is critical for agonistic activity. catechol 53-61 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 111-115 22886133-2 2012 Although PPO activity followed Michaelis-Menten kinetics at catechol concentrations of up to 1 mM, it slowly decreased at catechol concentrations above 2 mM. catechol 60-68 protoporphyrinogen oxidase Homo sapiens 9-12 22659205-3 2012 Due to the high catechol-loading capacity on the electrode surface and the upstanding electric conductivity of cobalt ferrite nanocomposite, the electrochemical response of the fabricated sensor was greatly enhanced and displayed excellent analytical performance for catechol detection from 1 to 200 muM with a low detection limit of 0.12 muM (S/N=3). catechol 267-275 latexin Homo sapiens 300-303 22659205-3 2012 Due to the high catechol-loading capacity on the electrode surface and the upstanding electric conductivity of cobalt ferrite nanocomposite, the electrochemical response of the fabricated sensor was greatly enhanced and displayed excellent analytical performance for catechol detection from 1 to 200 muM with a low detection limit of 0.12 muM (S/N=3). catechol 267-275 latexin Homo sapiens 339-342 22886133-2 2012 Although PPO activity followed Michaelis-Menten kinetics at catechol concentrations of up to 1 mM, it slowly decreased at catechol concentrations above 2 mM. catechol 122-130 protoporphyrinogen oxidase Homo sapiens 9-12 22886133-3 2012 This result indicated that in addition to the active site (site A), the enzyme possesses a second catechol-binding site (site B) that exerts an inhibitory effect on PPO activity. catechol 98-106 protoporphyrinogen oxidase Homo sapiens 165-168 22886133-7 2012 A steady-state kinetic analysis demonstrated that the dissociation constant between catechol and PPO depended on the binding of halides to site B. catechol 84-92 protoporphyrinogen oxidase Homo sapiens 97-100 22841723-2 2012 The co-crystal structure reveals a binding configuration which is unique compared to classical catechol PDE4 inhibitors, with boron binding to the activated water in the bimetal center. catechol 95-103 phosphodiesterase 4A Homo sapiens 104-108 22794353-10 2012 As in the case of luteolin, the pyrocatechol group of AG99 is critical for binding, interacting with the positive area in the deepest part of the CK2 active site. catechol 32-44 Calcium-dependent protein kinase 6 Zea mays 146-149 22847275-1 2012 This combined experimental (STM, XPS) and molecular dynamics simulation study highlights the complex and subtle interplay of solvent effects and surface interactions on the 2-D self-assembly pattern of a Schiff-base macrocycle containing catechol moieties at the liquid-solid interface. catechol 238-246 sulfotransferase family 1A member 3 Homo sapiens 28-31 22728921-6 2012 The phenol NPrCAP was shown to be activated by mushroom tyrosinase to the ortho-quinone N-propionyl-4-S-cysteaminyl-1,2-benzoquinone (NPrCAQ), and the structure was confirmed by reducing it to the corresponding catechol. catechol 211-219 tyrosinase Mus musculus 56-66 22923580-3 2012 The biosynthesis of arabidopyrones requires a cytochrome P450 enzyme (CYP84A4) to generate the catechol-substituted substrate for an extradiol ring-cleavage dioxygenase (AtLigB). catechol 95-103 Cytochrome P450 superfamily protein Arabidopsis thaliana 70-77 22867434-5 2012 Conversion of 3,5-DTBC to 3,5-DTBQ catalyzed by mononuclear complexes (5-7) is observed to proceed via formation of two enzyme-substrate adducts, ES1 and ES2, detected spectroscopically, a finding reported for the first time in any Zn(II) complex catalyzed oxidation of catechol. catechol 271-279 glutamine amidotransferase class 1 domain containing 3 Homo sapiens 147-150 22867434-5 2012 Conversion of 3,5-DTBC to 3,5-DTBQ catalyzed by mononuclear complexes (5-7) is observed to proceed via formation of two enzyme-substrate adducts, ES1 and ES2, detected spectroscopically, a finding reported for the first time in any Zn(II) complex catalyzed oxidation of catechol. catechol 271-279 ess-2 splicing factor homolog Homo sapiens 155-158 22590703-5 2012 Moreover, the excellent differential pulse voltammetric (DPV) response toward dopamine, hydroquinone and catechol was obtained and the detection limits was determined to be 0.337, 0.289 and 0.369 muM, respectively. catechol 105-113 latexin Homo sapiens 196-199 22596041-2 2012 On MDA-MB-231 breast cancer cell lines, the catechol compounds display a similar or greater anti-proliferative potency (IC(50) values ranging from 0.48-1.21 muM) than their corresponding phenolic analogues (0.57-12.7 muM), with the highest activity found for species incorporating the [3]ferrocenophane motif. catechol 44-52 latexin Homo sapiens 157-160 22596041-2 2012 On MDA-MB-231 breast cancer cell lines, the catechol compounds display a similar or greater anti-proliferative potency (IC(50) values ranging from 0.48-1.21 muM) than their corresponding phenolic analogues (0.57-12.7 muM), with the highest activity found for species incorporating the [3]ferrocenophane motif. catechol 44-52 latexin Homo sapiens 217-220 25585710-7 2012 The peroxidatic activity of cyt c immobilized in the chitosan layer for catechol was found to be below 1 per mill and for p-aminophenol about 3% as compared with that of heme or MP-11. catechol 72-80 cytochrome c, somatic Homo sapiens 28-33 22705957-3 2012 After in situ surface functionalization of NPs with oligodopa, formaldehyde dehydrogenase is immobilized on the surface of NPs through amine-catechol adduct reaction. catechol 141-149 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 63-89 22698780-1 2012 In vitro studies, using combined spectrophotometry and oximetry together with hplc/ms examination of the products of tyrosinase action demonstrate that hydroquinone is not a primary substrate for the enzyme but is vicariously oxidised by a redox exchange mechanism in the presence of either catechol, L-3,4-dihydroxyphenylalanine or 4-ethylphenol. catechol 291-299 tyrosinase Homo sapiens 117-127 22483290-3 2012 This review summarizes the major classes of COMT inhibitors, from early catechol and pyrogallol variants to bisubstrate inhibitors. catechol 72-80 catechol-O-methyltransferase Homo sapiens 44-48 22334593-0 2012 Ligand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D(1) receptor catechol agonists. catechol 112-120 dopamine receptor D1 Homo sapiens 89-111 21557334-1 2012 In vitro studies have found that flavanol epigallocatechin (EGC) and flavonols, but not flavanol epicatechin (EC), activate glutathione S-transferases (GSTs), a family of phase II enzymes that detoxify reactive oxygen species, such as catechol estrogen metabolites. catechol 235-243 glutathione S-transferase mu 1 Homo sapiens 152-156 22342555-1 2012 We study the suicide inactivation of tyrosinase acting on o-aminophenols and aromatic o-diamines and compare the results with those obtained for the corresponding o-diphenols. catechol 163-174 tyrosinase Homo sapiens 37-47 22500608-3 2012 Here we show that serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K(i) = 44 muM). catechol 42-50 catechol-O-methyltransferase Homo sapiens 72-76 22500608-3 2012 Here we show that serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K(i) = 44 muM). catechol 42-50 latexin Homo sapiens 301-304 22500608-3 2012 Here we show that serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K(i) = 44 muM). catechol 192-200 catechol-O-methyltransferase Homo sapiens 42-70 22500608-3 2012 Here we show that serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K(i) = 44 muM). catechol 192-200 catechol-O-methyltransferase Homo sapiens 72-76 22500608-3 2012 Here we show that serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K(i) = 44 muM). catechol 192-200 latexin Homo sapiens 301-304 22285433-0 2012 Catechol metabolites of zeranol and 17beta-estradiol: a comparative in vitro study on the induction of oxidative DNA damage and methylation by catechol-O-methyltransferase. catechol 0-8 catechol-O-methyltransferase Homo sapiens 143-171 22285433-2 2012 We have recently reported that alpha-ZAL and its major metabolite zearalanone (ZAN) are hydroxylated at the aromatic ring by microsomes from human liver in vitro, thereby forming two catechol metabolites each. catechol 183-191 zonadhesin Homo sapiens 79-82 22285433-4 2012 As these catechol metabolites are believed to mediate the carcinogenicity of E2 and E1 by causing oxidative DNA damage and DNA adducts, their methylation by catechol-O-methyltransferase (COMT) is an important inactivation pathway. catechol 9-17 cystatin 12, pseudogene Homo sapiens 77-86 22285433-4 2012 As these catechol metabolites are believed to mediate the carcinogenicity of E2 and E1 by causing oxidative DNA damage and DNA adducts, their methylation by catechol-O-methyltransferase (COMT) is an important inactivation pathway. catechol 9-17 catechol-O-methyltransferase Homo sapiens 157-185 22285433-4 2012 As these catechol metabolites are believed to mediate the carcinogenicity of E2 and E1 by causing oxidative DNA damage and DNA adducts, their methylation by catechol-O-methyltransferase (COMT) is an important inactivation pathway. catechol 9-17 catechol-O-methyltransferase Homo sapiens 187-191 22285433-5 2012 Here we report that hepatic microsomes from five species generate catechol metabolites of alpha-ZAL and ZAN, the highest amounts being formed by human liver microsomes, followed by rat, mouse, steer and swine. catechol 66-74 zonadhesin Homo sapiens 104-107 22285433-9 2012 Thus, some catechol metabolites of alpha-ZAL and ZAN are better pro-oxidants and poorer substrates of COMT than the catechols of E2 and E1. catechol 11-19 zonadhesin Homo sapiens 35-52 22285433-9 2012 Thus, some catechol metabolites of alpha-ZAL and ZAN are better pro-oxidants and poorer substrates of COMT than the catechols of E2 and E1. catechol 11-19 catechol-O-methyltransferase Homo sapiens 102-106 22285433-9 2012 Thus, some catechol metabolites of alpha-ZAL and ZAN are better pro-oxidants and poorer substrates of COMT than the catechols of E2 and E1. catechol 11-19 cystatin 12, pseudogene Homo sapiens 129-138 22172649-1 2012 A novel nanocomposite film of tyrosinase-chitosan-carbon-coated nickel nanoparticles (CNi) had been constructed for the detection of catechol. catechol 133-141 tyrosinase Homo sapiens 30-40 22386242-7 2012 Comparison of structures of caffeic acid and sinapic acid implied that catechol moiety of cinnamic acid derivatives is a major contributing factor for selective inhibition of COX-2. catechol 71-79 mitochondrially encoded cytochrome c oxidase II Homo sapiens 175-180 22342555-2 2012 The catalytic constants follow the order aromatic o-diamines<o-aminophenols<o-diphenols, which agrees with the view that the transfer of the proton to the peroxide group of the oxy-tyrosinase form is the slowest step in the catalytic cycle. catechol 82-93 tyrosinase Homo sapiens 187-197 22290292-5 2012 In model reactions with tyrosinase, the catechol metabolites of LY2066948 and equilenin were products; interestingly, in the presence of ascorbate to inhibit autoxidation, these catechols were formed quantitatively. catechol 40-48 tyrosinase Equus caballus 24-34 22290796-1 2012 The large tendency of catechol rings to adsorb on surfaces has been studied by STM experiments with molecular resolution combined with molecular-dynamics simulations. catechol 22-30 sulfotransferase family 1A member 3 Homo sapiens 79-82 22103597-5 2012 We identified a tomato O-methyltransferase (CTOMT1) with homology to a Nicotiana tabacum catechol OMT. catechol 89-97 catechol-O-methyltransferase 1 Solanum lycopersicum 44-50 22103597-8 2012 Recombinant CTOMT1 enzyme preferentially methylated catechol, producing guaiacol. catechol 52-60 catechol-O-methyltransferase 1 Solanum lycopersicum 12-18 22103597-11 2012 CTOMT1 overexpression resulted in slightly increased fruit guaiacol emission, which suggested that catechol availability might limit guaiacol production. catechol 99-107 catechol-O-methyltransferase 1 Solanum lycopersicum 0-6 22103597-12 2012 To test this hypothesis, wild type (WT) and CTOMT1 that overexpress tomato pericarp discs were supplied with exogenously applied catechol. catechol 129-137 catechol-O-methyltransferase 1 Solanum lycopersicum 44-50 22129592-1 2012 OBJECTIVES: To determine whether the catechol functional group on echinocandins decreases the catechol-O-methyltransferase (COMT) metabolism of catechol oestrogens (CEs) and the potential role of this functional group in the development of hepatocellular cancer. catechol 37-45 catechol-O-methyltransferase Homo sapiens 94-122 21982436-0 2012 Contribution of flavonoids and catechol to the reduction of ICAM-1 expression in endothelial cells by a standardised Willow bark extract. catechol 31-39 intercellular adhesion molecule 1 Homo sapiens 60-66 21982436-6 2012 The flavonoid and chalcone glycosides were not active up to 50 muM, whereas catechol and eriodictyol at the same concentration showed a significant reduction of ICAM-1 expression to 50% of control. catechol 76-84 intercellular adhesion molecule 1 Homo sapiens 161-167 22129592-1 2012 OBJECTIVES: To determine whether the catechol functional group on echinocandins decreases the catechol-O-methyltransferase (COMT) metabolism of catechol oestrogens (CEs) and the potential role of this functional group in the development of hepatocellular cancer. catechol 37-45 catechol-O-methyltransferase Homo sapiens 124-128 22129592-1 2012 OBJECTIVES: To determine whether the catechol functional group on echinocandins decreases the catechol-O-methyltransferase (COMT) metabolism of catechol oestrogens (CEs) and the potential role of this functional group in the development of hepatocellular cancer. catechol 94-102 catechol-O-methyltransferase Homo sapiens 124-128 21995306-0 2012 Binding to PLA2 may contribute to the anti-inflammatory activity of catechol. catechol 68-76 phospholipase A2 group IB Homo sapiens 11-15 23207768-7 2012 On the other hand, CAQ-mediated stabilization of HIF-1alpha is reversed by Fe(2+) but not by Zn(2+). catechol 19-22 hypoxia inducible factor 1 alpha subunit Gallus gallus 49-59 21995306-5 2012 By means of enzyme kinetic study, it was revealed that catechol can inhibit PLA(2) also. catechol 55-63 phospholipase A2 group IB Homo sapiens 76-82 21995306-6 2012 Crystal structure showed that catechol binds to PLA(2) at the opening of the active site cleft. catechol 30-38 phospholipase A2 group IB Homo sapiens 48-54 21995306-8 2012 Hence, catechol can be used as a lead compound for the development of novel anti-inflammatory drugs with PLA(2) as the target. catechol 7-15 phospholipase A2 group IB Homo sapiens 105-111 21111850-3 2011 Tyrosinase was employed to convert tyramine-conjugated micelles to highly reactive catechol conjugated micelles that could further cross-link individual Pluronic copolymer micelles to form a highly stable gel structure. catechol 83-91 tyrosinase Homo sapiens 0-10 21994917-0 2011 An electrochemical platform for acetylcholinesterase activity assay and inhibitors screening based on Michael addition reaction between thiocholine and catechol-terminated SAMs. catechol 152-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 21994917-0 2011 An electrochemical platform for acetylcholinesterase activity assay and inhibitors screening based on Michael addition reaction between thiocholine and catechol-terminated SAMs. catechol 152-160 methionine adenosyltransferase 1A Homo sapiens 172-176 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. catechol 287-295 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. catechol 287-295 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 21994917-2 2011 For understanding and confirming the mechanism of the reaction, the electrochemical behaviors of Michael addition reaction of two model compounds, cysteine (CYS) and glutathione (GSH), towards the catechol-terminated SAMs have been studied. catechol 197-205 methionine adenosyltransferase 1A Homo sapiens 217-221 21831422-0 2011 Surface camouflage of pancreatic islets using 6-arm-PEG-catechol in combined therapy with tacrolimus and anti-CD154 monoclonal antibody for xenotransplantation. catechol 56-64 CD40 ligand Mus musculus 110-115 21831422-6 2011 Interestingly, when the recipients of 6-arm-PEG-catechol grafted islets were treated with 0.2 mg/kg of FK506 and 0.1 mg/mouse of MR1, normoglycemia was maintained up to 50 days of transplantation without any fluctuation of glucose level. catechol 48-56 major histocompatibility complex, class I-related Mus musculus 129-132 21704506-4 2011 By chronoamperometry, the sensors present excellent sensitivity (20 nA muM(-1)) in a wide linear range (R(2)=0.994) up to 900 muM and limit of detection (s/n=3) of 37.5 x 10(-8)M for catechol. catechol 183-191 PWWP domain containing 3A, DNA repair factor Homo sapiens 71-77 21704506-7 2011 In voltammetry measurements, the calibration curve shows a good linearity (R(2)=0.992) in the range of catechol up to 500 muM with a sensitivity of 90 nA muM(-1) and LD of 8 muM. catechol 103-111 PWWP domain containing 3A, DNA repair factor Homo sapiens 154-160 21777512-7 2011 However, methoxylated catechol estrogens have been shown to induce ER-mediated signaling pathways, implying that conjugation is not a simply detoxification pathway. catechol 22-30 estrogen receptor 1 Homo sapiens 67-69 21777512-8 2011 Dual action of catechol estrogen metabolites in mammary carcinogenesis as the ER-signaling molecules and chemical carcinogen will be discussed in this review. catechol 15-23 estrogen receptor 1 Homo sapiens 78-80 21731105-1 2011 Catechol O-methyltransferase (COMT) metabolizes catechol moieties by methylating a single hydroxyl group at the meta- or para- hydroxyl position. catechol 48-56 catechol-O-methyltransferase Homo sapiens 0-28 21731105-1 2011 Catechol O-methyltransferase (COMT) metabolizes catechol moieties by methylating a single hydroxyl group at the meta- or para- hydroxyl position. catechol 48-56 catechol-O-methyltransferase Homo sapiens 30-34 21839122-0 2011 Determination of catalase activity using chromogenic probe involving iso-nicotinicacidhydrazide and pyrocatechol. catechol 100-112 catalase Homo sapiens 17-25 21839122-1 2011 A biocatalatic pathway involving chromogenic probe has been proposed for the determination of catalase activity by means of iso-nicotinicacidhydrazide (INH) and pyrocatechol (PC). catechol 161-173 catalase Homo sapiens 94-102 21778063-0 2011 Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups. catechol 160-168 PC4 and SFRS1 interacting protein 1 Homo sapiens 100-105 21778063-0 2011 Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups. catechol 160-168 PC4 and SFRS1 interacting protein 1 Homo sapiens 106-109 21351248-4 2011 Four catechol metabolites of AOH and two of AME, together with several of their O-methylation products, as catalyzed by catechol-O-methyl transferase, were clearly identified after incubation of the liver slices with AOH and AME. catechol 5-13 catechol-O-methyltransferase Rattus norvegicus 120-149 21305449-0 2011 Catechol, a bioactive degradation product of salicortin, reduces TNF-alpha induced ICAM-1 expression in human endothelial cells. catechol 0-8 tumor necrosis factor Homo sapiens 65-74 21305449-0 2011 Catechol, a bioactive degradation product of salicortin, reduces TNF-alpha induced ICAM-1 expression in human endothelial cells. catechol 0-8 intercellular adhesion molecule 1 Homo sapiens 83-89 21305449-6 2011 Considering this degradation in the IN VITRO test system, 10 microM catechol was added 8 h after TNF- alpha stimulation, and 16 h later the ICAM-1 expression was determined. catechol 68-76 tumor necrosis factor Homo sapiens 97-107 21695287-1 2011 Catechol-O-methyltransferase (COMT) metabolizes catechol neurotransmitters dopamine, noradrenaline and adrenaline that are involved in various physiological functions including mood, cognition and stress response. catechol 48-56 catechol-O-methyltransferase Homo sapiens 0-28 21695287-1 2011 Catechol-O-methyltransferase (COMT) metabolizes catechol neurotransmitters dopamine, noradrenaline and adrenaline that are involved in various physiological functions including mood, cognition and stress response. catechol 48-56 catechol-O-methyltransferase Homo sapiens 30-34 21538606-2 2011 COMT catalyzes the transfer of an activated methyl group from S-adenosylmethionine (SAM) to its catechol substrates, such as L-dopa, in the presence of magnesium ions. catechol 96-104 catechol-O-methyltransferase Homo sapiens 0-4 21402622-1 2011 The cytochrome P450 1A1 (CYP1A1) is a phase I enzyme involved in many oxidative reactions that has attracted considerable attention as a candidate gene for lung cancer susceptibility based on its function as a key factor required for bioactivation of carcinogenic polycyclic aromatic hydrocarbons and catechol oestrogen formation. catechol 301-309 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-23 21402622-1 2011 The cytochrome P450 1A1 (CYP1A1) is a phase I enzyme involved in many oxidative reactions that has attracted considerable attention as a candidate gene for lung cancer susceptibility based on its function as a key factor required for bioactivation of carcinogenic polycyclic aromatic hydrocarbons and catechol oestrogen formation. catechol 301-309 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 21371608-6 2011 Upon enzymatic characterization, purified COMT displayed methylating activity toward dopamine, dopa, and catecholestrogens, as well as three representative catechol drugs, methyldopa, dobutamine, and isoproterenol. catechol 105-113 catechol-O-methyltransferase b Danio rerio 42-46 21413031-8 2011 As compared with the use of a flat electrode of a similar diameter, the use of the pillar electrode led to improvements in both the sensitivity (72.1 pA/muM for the pillar versus 4.2 pA/muM for the flat electrode) and limit of detection (20 nM for the pillar versus 600 nM for the flat electrode), with catechol being the test analyte. catechol 303-311 latexin Homo sapiens 153-156 21413031-8 2011 As compared with the use of a flat electrode of a similar diameter, the use of the pillar electrode led to improvements in both the sensitivity (72.1 pA/muM for the pillar versus 4.2 pA/muM for the flat electrode) and limit of detection (20 nM for the pillar versus 600 nM for the flat electrode), with catechol being the test analyte. catechol 303-311 latexin Homo sapiens 186-189 21240422-3 2011 The principle of catechol estimation was based on the reduction of biocatalytically liberated quinone species at +0.2 V versus Ag/AgCl (3 M KCl), with good stability, sensitivity, and featuring a low detection limit (about 0.002 muM) and wide linear range (0.005 muM-120 muM). catechol 17-25 latexin Homo sapiens 229-232 21240422-3 2011 The principle of catechol estimation was based on the reduction of biocatalytically liberated quinone species at +0.2 V versus Ag/AgCl (3 M KCl), with good stability, sensitivity, and featuring a low detection limit (about 0.002 muM) and wide linear range (0.005 muM-120 muM). catechol 17-25 latexin Homo sapiens 263-266 21240422-3 2011 The principle of catechol estimation was based on the reduction of biocatalytically liberated quinone species at +0.2 V versus Ag/AgCl (3 M KCl), with good stability, sensitivity, and featuring a low detection limit (about 0.002 muM) and wide linear range (0.005 muM-120 muM). catechol 17-25 latexin Homo sapiens 263-266 21240422-4 2011 The electrochemical redox peak of catechol on the GCE/PolyPATT/Den(AuNPs)/tyrosinase was also investigated. catechol 34-42 tyrosinase Homo sapiens 74-84 21242086-5 2011 On an electrode, ALP-catalyzed hydrolysis of phenyl phosphate generated phenol, and successive TYR-catalyzed oxidation of phenol produced electrochemically measurable o-quinone that was converted to catechol in a scheme of substrate recycling. catechol 199-207 alkaline phosphatase, placental Homo sapiens 17-20 21242086-5 2011 On an electrode, ALP-catalyzed hydrolysis of phenyl phosphate generated phenol, and successive TYR-catalyzed oxidation of phenol produced electrochemically measurable o-quinone that was converted to catechol in a scheme of substrate recycling. catechol 199-207 tyrosinase Homo sapiens 95-98 21371608-8 2011 These results provide a foundation for investigating the involvement of COMT-mediated methylation in protection against the adverse effects of catechol drugs and other xenobiotic catechols during the developmental process. catechol 143-151 catechol-O-methyltransferase b Danio rerio 72-76 21163638-5 2011 Compared to other unmediated tyrosinase biosensors, the CFP-based tyrosinase biosensor offers a high sensitivity for the monitoring of phenolic compounds (17.8, 7.1, 5.2 and 3.7 muA muM(-1)cm(-2) for catechol, phenol, bisphenol and 3-aminophenol, respectively). catechol 200-208 tyrosinase Homo sapiens 66-76 21542347-0 2011 [Calcium-dioxolene complexes: rate constants of pyrocatechol oxidation in the presence of Ca2+]. catechol 48-60 carbonic anhydrase 2 Homo sapiens 90-93 21542347-2 2011 The effect of Ca2+ on the oxygen absorption rate has been studied, and a kinetic model has been suggested, which takes different stages of interaction of pyrocatechol and its radical form with oxygen into account. catechol 154-166 carbonic anhydrase 2 Homo sapiens 14-17 21106301-4 2011 Catechol estrogens are formed from E(2) by the actions of cytochrome p450 1B1 (CYP1B1). catechol 0-8 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 58-77 21106301-4 2011 Catechol estrogens are formed from E(2) by the actions of cytochrome p450 1B1 (CYP1B1). catechol 0-8 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 79-85 21168353-0 2011 Studying the catechol binding cavity in comparative models of human dopamine D2 receptor. catechol 13-21 dopamine receptor D2 Homo sapiens 68-88 21240422-1 2011 Tyrosinase has been immobilized on a Au nanoparticles encapsulated-dendrimer bonded conducting polymer on a glassy carbon electrode for the estimation of catechol. catechol 154-162 tyrosinase Homo sapiens 0-10 21168353-2 2011 In this study attempts have been made to develop a functional model for the catechol binding site of the human dopamine D(2) receptor, with two primary models being postulated based on the presence of a disulfide bridge in the second extracellular loop. catechol 76-84 dopamine receptor D2 Homo sapiens 111-133 21887411-2 2011 Tyrosinase shows kinetic cooperativity in its action on o-diphenols, but not when it acts on monophenols, confirming that the slow step is the hydroxylation of monophenols to o-diphenols. catechol 56-67 tyrosinase Homo sapiens 0-10 21456242-2 2011 Bands at 1152 and 1322 cm(-1) were also similar to SERS of metal catecholates, and could be assigned to catechol ring vibration and carbon-oxygen stretches. catechol 65-73 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 51-55 20718051-7 2011 Galloylated catechins and pyrogallol-type catechins exhibited higher binding affinities for HSA than non-galloylated and catechol-type catechins, respectively. catechol 121-129 albumin Homo sapiens 92-95 21123042-1 2011 This paper describes the preparation of a biomimetic Langmuir-Blodgett film of tyrosinase incorporated in a lipidic layer and the use of lutetium bisphthalocyanine as an electron mediator for the voltammetric detection of phenol derivatives, which include one monophenol (vanillic acid), two diphenols (catechol and caffeic acid) and two triphenols (gallic acid and pyrogallol). catechol 303-311 tyrosinase Homo sapiens 79-89 21887411-2 2011 Tyrosinase shows kinetic cooperativity in its action on o-diphenols, but not when it acts on monophenols, confirming that the slow step is the hydroxylation of monophenols to o-diphenols. catechol 175-186 tyrosinase Homo sapiens 0-10 21467630-7 2011 Thus, it is likely that pro-PHBP binds these potent inhibitors through its site(s) that recognize a catechol-like structure. catechol 100-108 hyaluronan binding protein 2 Homo sapiens 28-32 22066229-2 2011 The resulting TYR-immobilized carbon felt was used as a working electrode unit of bioelectrocatalytic flow-through detector for TYR substrates (catechol, p-chlorophenol (p-CP), p-cresol, phenol etc.). catechol 144-152 tyrosinase Homo sapiens 14-17 21769726-3 2011 The catechol-O-methyltransferase (COMT) gene, which encodes an enzyme that metabolises catechol compounds, including dopamine, is a leading candidate in this regard. catechol 4-12 catechol-O-methyltransferase Homo sapiens 34-38 21979097-0 2011 Elucidation of crucial structures for a catechol-based inhibitor of plasma hyaluronan-binding protein (factor VII activating protease) autoactivation. catechol 40-48 hyaluronan binding protein 2 Homo sapiens 68-101 21979097-0 2011 Elucidation of crucial structures for a catechol-based inhibitor of plasma hyaluronan-binding protein (factor VII activating protease) autoactivation. catechol 40-48 hyaluronan binding protein 2 Homo sapiens 103-133 21979097-2 2011 Previous investigations have suggested the presence of catechol-binding sites in its proenzyme form, pro-PHBP. catechol 55-63 hyaluronan binding protein 2 Homo sapiens 105-109 21979097-3 2011 Here we found that compounds with plural catechol groups conjugated with strong electron-withdrawing groups, such as tyrphostin AG 537 (IC(50)=18 nM), were potent inhibitors of pro-PHBP activation. catechol 41-49 hyaluronan binding protein 2 Homo sapiens 181-185 22066229-2 2011 The resulting TYR-immobilized carbon felt was used as a working electrode unit of bioelectrocatalytic flow-through detector for TYR substrates (catechol, p-chlorophenol (p-CP), p-cresol, phenol etc.). catechol 144-152 tyrosinase Homo sapiens 128-131 20830428-0 2010 Generation of surface-confined catechol terminated SAMs via electrochemically triggered Michael addition: characterization, electrochemistry and complex with Ni(II) and Cu(II) cations. catechol 31-39 methionine adenosyltransferase 1A Homo sapiens 51-55 22105135-3 2011 The redox reaction between Fe(III) and the DHBs 1,2-dihydroxybenzene (catechol, CAT), 2,3-dihydroxybenzoic acid (2,3-DHBA), 3,4-dihydroxybenzoic acid (3,4-DHBA), and 1,2-dihydroxy-3,5-benzenedisulfonate (TIRON) was studied by cyclic voltammetry to better understand the enhanced reactivity of the DHB driven Fenton reaction. catechol 48-68 catalase Homo sapiens 80-83 20942401-2 2010 It is able to regenerate the o-diphenol group of enzymatically oxidized trans-caftaric acid, giving rise to 2-S-glutathionyl-trans-caftaric acid (also known as grape reaction product, GRP) and thus inhibiting the browning of wine. catechol 29-39 gastrin releasing peptide Homo sapiens 184-187 21799835-7 2011 Scavenging of hydroxyl radical by mannitol, inhibition of intrinsic lipoxygenase by catechol and removal of molecular oxygen considerably suppressed ultra-weak photon emission measured after the addition of linoleic acid. catechol 84-92 uncharacterized protein Chlamydomonas reinhardtii 68-80 21087115-5 2011 It was shown that mutants of the bacterial P450 BM3 could be used to produce the human relevant 13- and 15-OH-ZEN catechol metabolites at such levels that their ERalpha affinity could be determined in an HRS setup, which was not possible with HLM. catechol 114-122 estrogen receptor 1 Homo sapiens 161-168 20830428-3 2010 The catechol-terminated SAMs, via electrochemically triggered Michael addition reaction, exhibit reversible redox response. catechol 4-12 methionine adenosyltransferase 1A Homo sapiens 24-28 20830428-4 2010 In addition, we find that catechol-terminated SAMs can complex with Ni(2+) and Cu(2+) with different electrochemical behaviors. catechol 26-34 methionine adenosyltransferase 1A Homo sapiens 46-50 20830428-5 2010 Moreover, the mechanism of complexation of Ni(2+)and Cu(2+) with catechol-terminated SAMs is also demonstrated with electrochemical and spectrometric methods. catechol 65-73 methionine adenosyltransferase 1A Homo sapiens 85-89 20830428-6 2010 Based on the different electrochemical behaviors of Cu(2+) and Ni(2+) complex, the catechol-terminated SAMs provide a potential platform for metal ions recognition. catechol 83-91 methionine adenosyltransferase 1A Homo sapiens 103-107 20606002-0 2010 O-methylation of catechol estrogens by human placental catechol-o-methyltransferase: interindividual differences in sensitivity to heat inactivation and to inhibition by dietary polyphenols. catechol 17-25 catechol-O-methyltransferase Homo sapiens 55-83 20606002-1 2010 The human catechol-O-methyltransferase (COMT) is a polymorphic enzyme that catalyzes the O-methylation of catechol estrogens. catechol 10-18 catechol-O-methyltransferase Homo sapiens 40-44 20606002-3 2010 In this study, we analyzed a total of 36 human term placentas to determine their cytosolic COMT activity for the O-methylation of catechol estrogens as well as their sensitivity to inhibition by heat and dietary compounds. catechol 130-138 catechol-O-methyltransferase Homo sapiens 91-95 20945454-9 2010 The catechol of BPA may also alter expression of estrogen-activating and deactivating enzymes, and/or compete with methoxylation of 4-OHE(1)(E(2)) by catechol-O-methyltransferase, thereby unbalancing the metabolism of estrogens to increase formation of E(1)(E(2))-3,4-Q and the depurinating estrogen-DNA adducts leading to cancer initiation. catechol 4-12 catechol-O-methyltransferase Homo sapiens 150-178 20599928-7 2010 On the other hand, the NFkappaB inhibitory effect of CAPE was diminished by removal or modification of the Michael reaction acceptor, catechol or phenethyl moiety in CAPE. catechol 134-142 nuclear factor kappa B subunit 1 Homo sapiens 23-31 20558128-10 2010 We hypothesize that an electrophilic quinone formed as a consequence of oxidation of piceatannol bearing the catechol moiety may bind directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm. catechol 109-117 kelch like ECH associated protein 1 Homo sapiens 146-181 20558128-10 2010 We hypothesize that an electrophilic quinone formed as a consequence of oxidation of piceatannol bearing the catechol moiety may bind directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm. catechol 109-117 kelch like ECH associated protein 1 Homo sapiens 183-188 20558128-10 2010 We hypothesize that an electrophilic quinone formed as a consequence of oxidation of piceatannol bearing the catechol moiety may bind directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm. catechol 109-117 NFE2 like bZIP transcription factor 2 Homo sapiens 229-233 20558128-14 2010 The characteristic catechol moiety of piceatannol appears to be critical for induction of Nrf2 activation and subsequent upregulation of HO-1. catechol 19-27 NFE2 like bZIP transcription factor 2 Homo sapiens 90-94 20558128-14 2010 The characteristic catechol moiety of piceatannol appears to be critical for induction of Nrf2 activation and subsequent upregulation of HO-1. catechol 19-27 heme oxygenase 1 Homo sapiens 137-141 20659173-1 2010 Catechol-O-methyltransferase (COMT) is a ubiquitously expressed enzyme that maintains basic biologic functions by inactivating catechol substrates. catechol 127-135 catechol-O-methyltransferase Homo sapiens 30-34 20584749-7 2010 We speculate that an electrophilic quinone formed as a consequence of oxidation of PIC bearing the catechol moiety may directly interact with critical cysteine thiols of IKKbeta, thereby inhibiting its catalytic activity. catechol 99-107 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 170-177 20600213-13 2010 Inhibition of COMT activity by quercetin may expose breast cells chronically to E(2) and catechol estrogens. catechol 89-97 catechol-O-methyltransferase Rattus norvegicus 14-18 20581821-7 2010 As catechols derive from bacterial and mammalian metabolism of dietary compounds, the Scn-Ngal-catechol-Fe(III) complex represents an unforeseen microbial-host interaction, which mimics Scn-Ngal-siderophore interactions but instead traffics iron in aseptic tissues. catechol 3-11 lipocalin 2 Homo sapiens 90-94 20581821-0 2010 Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. catechol 59-67 lipocalin 2 Homo sapiens 53-57 20581821-4 2010 Using chemical screens, crystallography and fluorescence methods, we report that Scn-Ngal binds iron together with a small metabolic product called catechol. catechol 148-156 sorcin Homo sapiens 81-84 20581821-4 2010 Using chemical screens, crystallography and fluorescence methods, we report that Scn-Ngal binds iron together with a small metabolic product called catechol. catechol 148-156 lipocalin 2 Homo sapiens 85-89 20581821-7 2010 As catechols derive from bacterial and mammalian metabolism of dietary compounds, the Scn-Ngal-catechol-Fe(III) complex represents an unforeseen microbial-host interaction, which mimics Scn-Ngal-siderophore interactions but instead traffics iron in aseptic tissues. catechol 3-11 sorcin Homo sapiens 86-89 20507089-9 2010 Characterization of the GSH conjugate structures allowed insight(s) into the bioactivation pathway, which involved CYP3A4-mediated phenol ring oxidation to the catechol, followed by further oxidation to the electrophilic ortho-quinone species. catechol 160-168 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 115-121 20347921-8 2010 MIO-M1 cells showed significant decrease in cell viability, increased caspase-3/7 activity, elevated ROS/RNS levels, decreased DeltaPsim value, and decreased intracellular ATP content after exposure to catechol 150, 300, and 600 microM compared with control. catechol 202-210 caspase 3 Homo sapiens 70-79 20581821-7 2010 As catechols derive from bacterial and mammalian metabolism of dietary compounds, the Scn-Ngal-catechol-Fe(III) complex represents an unforeseen microbial-host interaction, which mimics Scn-Ngal-siderophore interactions but instead traffics iron in aseptic tissues. catechol 3-11 sorcin Homo sapiens 186-189 20581821-7 2010 As catechols derive from bacterial and mammalian metabolism of dietary compounds, the Scn-Ngal-catechol-Fe(III) complex represents an unforeseen microbial-host interaction, which mimics Scn-Ngal-siderophore interactions but instead traffics iron in aseptic tissues. catechol 3-11 lipocalin 2 Homo sapiens 190-194 20029997-5 2010 RESULTS: According to the mechanism proposed for tyrosinase, the enzymatic reaction involves the o-hydroxylation of the monophenol THC to the o-diphenol (PHC, 2",4",6",3,4 - pentahydroxychalcone), which is then oxidised to the corresponding o-quinone in a second enzymatic step. catechol 142-152 tyrosinase Homo sapiens 49-59 20305821-9 2010 Among the hit fragments, the small catechol molecule was shown to significantly inhibit Peroxiredoxin 5 activity in a thioredoxin peroxidase assay. catechol 35-43 peroxiredoxin 5 Homo sapiens 88-103 20157907-1 2010 The oxidative trimerization of catechol ketals by MoCl(5) or MoCl(5)/TiCl(4) mixtures leads preferentially to the all-syn stereoisomer of the corresponding triphenylene ketal. catechol 31-39 synemin Homo sapiens 118-121 20060283-0 2010 Amperometric catechol biosensor based on polyaniline-polyphenol oxidase. catechol 13-21 protoporphyrinogen oxidase Homo sapiens 53-71 20060283-1 2010 A novel catechol biosensor was described based on the immobilization of polyphenol oxidase (PPO) into polyaniline (PANI), which was easily constructed by direct electropolymerization of aniline in a solution containing ionic liquid, 1-ethyl-3-methylimidazolium ethyl sulfate (EMIES). catechol 8-16 protoporphyrinogen oxidase Homo sapiens 72-90 20060283-1 2010 A novel catechol biosensor was described based on the immobilization of polyphenol oxidase (PPO) into polyaniline (PANI), which was easily constructed by direct electropolymerization of aniline in a solution containing ionic liquid, 1-ethyl-3-methylimidazolium ethyl sulfate (EMIES). catechol 8-16 protoporphyrinogen oxidase Homo sapiens 92-95 20051261-8 2010 Catechol was a more potent suppressor of the up-regulation of iNOS promoter and NF-kappaB enhancer than rutin and yet, hesperidin alone failed to inhibit either activity. catechol 0-8 nitric oxide synthase 2, inducible Mus musculus 62-66 20051261-8 2010 Catechol was a more potent suppressor of the up-regulation of iNOS promoter and NF-kappaB enhancer than rutin and yet, hesperidin alone failed to inhibit either activity. catechol 0-8 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 80-89 20051261-9 2010 CONCLUSION: Our results indicate that catechol and rutin, but not hesperidin, are primary bioactive phenolic compounds in the crude extract to suppress NO production in LPS-stimulated macrophages via NF-kappaB-dependent iNOS gene transcription. catechol 38-46 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 200-209 20051261-9 2010 CONCLUSION: Our results indicate that catechol and rutin, but not hesperidin, are primary bioactive phenolic compounds in the crude extract to suppress NO production in LPS-stimulated macrophages via NF-kappaB-dependent iNOS gene transcription. catechol 38-46 nitric oxide synthase 2, inducible Mus musculus 220-224 20232338-3 2010 The Cyp6g1-transgenic cell culture metabolized 96% of applied methoxychlor (45.8 microg per assay) within 24 h by demethylation and hydroxylation mainly to trishydroxy and catechol methoxychlor (16 and 17%, resp.). catechol 172-180 Cyp6g1 Drosophila melanogaster 4-10 20007670-2 2010 CYP1A2, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 were identified as paroxetine-catechol-forming P450 isoforms, and CYP2C19 and CYP2D6 were identified as metabolizing P450 isoforms by substrate depletion. catechol 74-82 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-6 20007670-2 2010 CYP1A2, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 were identified as paroxetine-catechol-forming P450 isoforms, and CYP2C19 and CYP2D6 were identified as metabolizing P450 isoforms by substrate depletion. catechol 74-82 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 8-15 20007670-2 2010 CYP1A2, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 were identified as paroxetine-catechol-forming P450 isoforms, and CYP2C19 and CYP2D6 were identified as metabolizing P450 isoforms by substrate depletion. catechol 74-82 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 17-23 20007670-2 2010 CYP1A2, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 were identified as paroxetine-catechol-forming P450 isoforms, and CYP2C19 and CYP2D6 were identified as metabolizing P450 isoforms by substrate depletion. catechol 74-82 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 25-31 20007670-2 2010 CYP1A2, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 were identified as paroxetine-catechol-forming P450 isoforms, and CYP2C19 and CYP2D6 were identified as metabolizing P450 isoforms by substrate depletion. catechol 74-82 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 37-43 20097727-8 2010 The percentage of cells labeled with annexin V (apoptotic cells) was greater in the group exposed to catechol (20.7%) than in control cells (0.4%). catechol 101-109 annexin A5 Homo sapiens 37-46 20097727-9 2010 Exposure to catechol at concentrations greater than 100 microM enhanced Bax levels, and a decrease in Bcl-2 level was observed after the exposure to 600 microM catechol for 48 hours. catechol 12-20 BCL2 associated X, apoptosis regulator Homo sapiens 72-75 20097727-9 2010 Exposure to catechol at concentrations greater than 100 microM enhanced Bax levels, and a decrease in Bcl-2 level was observed after the exposure to 600 microM catechol for 48 hours. catechol 160-168 BCL2 apoptosis regulator Homo sapiens 102-107 18795241-2 2009 PPO from Coker 312, an embryogenic cultivar, showed a highest affinity to catechol 20 mM, and PPO from R405-2000, a nonembryogenic cultivar, showed a highest affinity to 4-methylcatechol 20 mM. catechol 74-82 polyphenol oxidase, chloroplastic-like Gossypium hirsutum 0-3 19931366-6 2010 The catechol metabolites of alpha-ZAL and ZAN are unstable and readily oxidized to quinones, which could be detected among the metabolites of alpha-ZAL and ZAN generated by human hepatic microsomes and hCYP1A2. catechol 4-12 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 202-209 20031422-3 2010 We report here a series of catechol compounds with great affinity for the PLAP isozyme and significant selectivity over other members of the AP superfamily. catechol 27-35 alkaline phosphatase, placental Homo sapiens 74-78 21095460-1 2010 Catechol-O-methyltransferase (COMT) is an important enzyme in the metabolism of catechol structured compounds such as catecholamines, catecholestrogens, and L-dopa. catechol 80-88 catechol-O-methyltransferase Mus musculus 0-28 21095460-1 2010 Catechol-O-methyltransferase (COMT) is an important enzyme in the metabolism of catechol structured compounds such as catecholamines, catecholestrogens, and L-dopa. catechol 80-88 catechol-O-methyltransferase Mus musculus 30-34 20336436-1 2010 Catechol-O-methyltransferase (COMT) is an enzyme that plays a key role in the modulation of catechol-dependent functions such as cognition, cardiovascular function, and pain processing. catechol 92-100 catechol-O-methyltransferase Homo sapiens 0-28 20336436-1 2010 Catechol-O-methyltransferase (COMT) is an enzyme that plays a key role in the modulation of catechol-dependent functions such as cognition, cardiovascular function, and pain processing. catechol 92-100 catechol-O-methyltransferase Homo sapiens 30-34 19846304-3 2009 The complex Cu(2)(II)-Hn5 effectively oxidizes catechol, exhibiting enzyme-like kinetics (k(cat)=0.011 and 0.060 s(-1) and k(cat)/K(m)=19 and 50 M(-1)s(-1) without and with 12.8mM H(2)O(2), respectively). catechol 47-55 histatin 3 Homo sapiens 22-25 19952498-0 2009 Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1. catechol 0-8 nuclear factor, erythroid derived 2, like 2 Mus musculus 42-46 19952498-0 2009 Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1. catechol 0-8 kelch-like ECH-associated protein 1 Mus musculus 106-111 19952498-3 2009 The purpose of the present study is to explore the roles of oxidative and electrophilic stress in Nrf2 activation caused by redox-active catechol estrogens. catechol 137-145 nuclear factor, erythroid derived 2, like 2 Mus musculus 98-102 19952498-7 2009 These results suggest that Nrf2 activation during redox cycling of catechol estrogens is dominantly attributable to formation of their ortho-quinones that covalently bind to Keap1. catechol 67-75 nuclear factor, erythroid derived 2, like 2 Mus musculus 27-31 19952498-7 2009 These results suggest that Nrf2 activation during redox cycling of catechol estrogens is dominantly attributable to formation of their ortho-quinones that covalently bind to Keap1. catechol 67-75 kelch-like ECH-associated protein 1 Mus musculus 174-179 19605895-1 2009 Catechol-O-methyltransferase (COMT) is an important enzyme involved in inactivation of catechol estrogens, which are metabolites with carcinogenic properties. catechol 87-95 catechol-O-methyltransferase Canis lupus familiaris 0-28 19605895-1 2009 Catechol-O-methyltransferase (COMT) is an important enzyme involved in inactivation of catechol estrogens, which are metabolites with carcinogenic properties. catechol 87-95 catechol-O-methyltransferase Canis lupus familiaris 30-34 19743802-8 2009 To examine the reactivity of the catechol type polyphenols, such as flavonoids, to endogenous beta-actin, RL34 cells were coexposed to Bio-DPA and the flavonoids quercetin, (-)-epicatechin, and (-)-epicatechin gallate. catechol 33-41 POTE ankyrin domain family member F Homo sapiens 94-104 19743802-10 2009 These results indicate that beta-actin is one of the major targets of protein modification by catechol type polyphenols and that Bio-DPA is an useful probe for understanding the redox regulation by dietary polyphenols. catechol 94-102 POTE ankyrin domain family member F Homo sapiens 28-38 19743802-11 2009 Furthermore, Keap1, a scaffold protein to the actin cytoskeleton controlling cytoprotective enzyme genes, was also identified as another plausible target of the catechol type polyphenols by oxidative modification of the intracellular sulfhydryls. catechol 161-169 kelch like ECH associated protein 1 Homo sapiens 13-18 19675891-0 2009 The influence of catechol structure on the suicide-inactivation of tyrosinase. catechol 17-25 tyrosinase Homo sapiens 67-77 19655315-5 2009 Moreover, both catechol metabolites of ZEN were substrates of the enzyme catechol-O-methyl transferase. catechol 15-23 catechol-O-methyltransferase Homo sapiens 73-102 19559588-6 2009 The proposed PPO/BiO(x) biosensor provided a linear response to catechol over a concentration range of 4 x 10(-9)M to 1.5 x 10(-5)M with a dramatically developed sensitivity of 11.3 AM(-1)cm(-2) and a detection limit of 1 x 10(-9)M based on S/N=3. catechol 64-72 protoporphyrinogen oxidase Homo sapiens 13-16 19922557-11 2009 In silico modeling suggests that among AC isoforms carbamazepine preferentially affects AC1 and AC5 by interacting with the catechol-estrogen site. catechol 124-132 adenylate cyclase 1 Mus musculus 88-91 19922557-11 2009 In silico modeling suggests that among AC isoforms carbamazepine preferentially affects AC1 and AC5 by interacting with the catechol-estrogen site. catechol 124-132 adenylate cyclase 5 Mus musculus 96-99 19930170-1 2009 BACKGROUND AND PURPOSE: Catechol-O-methyltransferase (COMT) metabolizes compounds containing catechol structures and has two forms: soluble (S-COMT) and membrane-bound (MB-COMT). catechol 93-101 catechol-O-methyltransferase Mus musculus 24-52 19930170-1 2009 BACKGROUND AND PURPOSE: Catechol-O-methyltransferase (COMT) metabolizes compounds containing catechol structures and has two forms: soluble (S-COMT) and membrane-bound (MB-COMT). catechol 93-101 catechol-O-methyltransferase Mus musculus 54-58 19930170-1 2009 BACKGROUND AND PURPOSE: Catechol-O-methyltransferase (COMT) metabolizes compounds containing catechol structures and has two forms: soluble (S-COMT) and membrane-bound (MB-COMT). catechol 93-101 catechol-O-methyltransferase Mus musculus 143-147 19930170-1 2009 BACKGROUND AND PURPOSE: Catechol-O-methyltransferase (COMT) metabolizes compounds containing catechol structures and has two forms: soluble (S-COMT) and membrane-bound (MB-COMT). catechol 93-101 catechol-O-methyltransferase Mus musculus 143-147 18829006-1 2009 Glutathione S-transferase (GSTM1) plays an important role in the excretion of catechol estrogens and is therefore a candidate marker for fibroids. catechol 78-86 glutathione S-transferase kappa 1 Homo sapiens 0-25 19362588-7 2009 On oxidation, polyphenols with B-ring catechol functionality form toxic alkylating quinones that are normally inactivated by cellular antioxidant defense and redox maintenance systems, including reduction by ascorbate and NAD(P)H:quinone oxidoreductase 1 (NQO1). catechol 38-46 NAD(P)H quinone dehydrogenase 1 Homo sapiens 222-254 19362588-7 2009 On oxidation, polyphenols with B-ring catechol functionality form toxic alkylating quinones that are normally inactivated by cellular antioxidant defense and redox maintenance systems, including reduction by ascorbate and NAD(P)H:quinone oxidoreductase 1 (NQO1). catechol 38-46 NAD(P)H quinone dehydrogenase 1 Homo sapiens 256-260 19426692-5 2009 Here we perform a proteomic based analysis of the livers of COMT-KO mice in search for potential compensatory mechanisms developed to cope with the effects of disrupted catechol metabolism. catechol 169-177 catechol-O-methyltransferase Mus musculus 60-64 19519772-5 2009 These findings suggest that catechol substrates interact symmetrically with both sides of DAT and non-catechol substrates, favoring binding to outward-facing transporter. catechol 28-36 solute carrier family 6 member 3 Homo sapiens 90-93 19519772-5 2009 These findings suggest that catechol substrates interact symmetrically with both sides of DAT and non-catechol substrates, favoring binding to outward-facing transporter. catechol 102-110 solute carrier family 6 member 3 Homo sapiens 90-93 19462939-4 2009 For investigation of the catechol-O-methylation catalyzed by the soluble form of the COMT (sCOMT), incubations with human liver cytosol (HLC) were performed. catechol 25-33 catechol-O-methyltransferase Homo sapiens 85-89 19097884-1 2009 The use of lignin peroxidase (LIP) as an alternative method for the removal of four catechols (1,2-dihydroxybenzene): catechol (CAT), 4-chlorocatechol (4-CC), 4,5-dichlorocatechol (4,5-DCC) and 4-methylcatechol (4-MC) typical pollutants in wastewater derived from oil and paper industries, was evaluated. catechol 95-115 DCC netrin 1 receptor Homo sapiens 185-188 18829006-1 2009 Glutathione S-transferase (GSTM1) plays an important role in the excretion of catechol estrogens and is therefore a candidate marker for fibroids. catechol 78-86 glutathione S-transferase mu 1 Homo sapiens 27-32 19158089-0 2009 Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus. catechol 100-108 estrogen receptor 1 Equus caballus 0-24 19236154-4 2009 Two strategies are known to increase Nrf2 transcriptional activity in PD: i) use of certain catechol-derived quinones for selective inhibition of the Nrf2 repressor Kelch-like ECH-associated protein to increase of Nrf2 protein levels; and ii) use of glycogen synthase kinase 3beta inhibitors to maintain high protein and activity levels of Nrf2 in the nucleus. catechol 92-100 NFE2 like bZIP transcription factor 2 Homo sapiens 37-41 19236154-4 2009 Two strategies are known to increase Nrf2 transcriptional activity in PD: i) use of certain catechol-derived quinones for selective inhibition of the Nrf2 repressor Kelch-like ECH-associated protein to increase of Nrf2 protein levels; and ii) use of glycogen synthase kinase 3beta inhibitors to maintain high protein and activity levels of Nrf2 in the nucleus. catechol 92-100 NFE2 like bZIP transcription factor 2 Homo sapiens 150-154 19236154-4 2009 Two strategies are known to increase Nrf2 transcriptional activity in PD: i) use of certain catechol-derived quinones for selective inhibition of the Nrf2 repressor Kelch-like ECH-associated protein to increase of Nrf2 protein levels; and ii) use of glycogen synthase kinase 3beta inhibitors to maintain high protein and activity levels of Nrf2 in the nucleus. catechol 92-100 NFE2 like bZIP transcription factor 2 Homo sapiens 150-154 19236154-4 2009 Two strategies are known to increase Nrf2 transcriptional activity in PD: i) use of certain catechol-derived quinones for selective inhibition of the Nrf2 repressor Kelch-like ECH-associated protein to increase of Nrf2 protein levels; and ii) use of glycogen synthase kinase 3beta inhibitors to maintain high protein and activity levels of Nrf2 in the nucleus. catechol 92-100 NFE2 like bZIP transcription factor 2 Homo sapiens 150-154 19258424-3 2009 Herein, we show that the hydroxystilbene, piceatannol, and related catechol ring-containing compounds are able to induce the loss of the Cbl family of proteins. catechol 67-75 Cbl proto-oncogene Homo sapiens 137-140 19258424-5 2009 Screening of a small library of piceatannol-like compounds indicated that aromaticity and a catechol ring were required for the induction of Cbl loss. catechol 92-100 Cbl proto-oncogene Homo sapiens 141-144 19258424-6 2009 Further examination of these two chemical properties showed that the oxidative conversion of the catechol ring of piceatannol into a highly reactive O-benzoquinone was the cause of piceatannol-induced Cbl loss. catechol 97-105 Cbl proto-oncogene Homo sapiens 201-204 25084402-5 2009 In this reaction, the electrochemically generated catechol compounds from o-quinones are re-oxidized repeatedly by catecholase activity of the TYR, leading to a sufficient amplified signal. catechol 50-58 tyrosinase Homo sapiens 143-146 18973935-3 2009 CYP1B1 is a cytochrome P450 enzyme that catalyzes the conversion of estrogens to genotoxic catechol estrogens which may cause DNA mutations and initiate ovarian epithelial cancer. catechol 91-99 cytochrome P450 family 1 subfamily B member 1 Gallus gallus 0-6 19074205-3 2009 Catechol-O-methyltransferase (COMT) catalyzes catechol estrogens and tea polyphenols. catechol 46-54 catechol-O-methyltransferase Homo sapiens 0-28 19074205-3 2009 Catechol-O-methyltransferase (COMT) catalyzes catechol estrogens and tea polyphenols. catechol 46-54 catechol-O-methyltransferase Homo sapiens 30-34 19095062-0 2009 Inhibition of human catechol-O-methyltransferase (COMT)-mediated O-methylation of catechol estrogens by major polyphenolic components present in coffee. catechol 20-28 catechol-O-methyltransferase Homo sapiens 50-54 19004651-2 2009 L-Chicoric acid (L-CA) is a bidentate catechol that has been identified as a potent inhibitor of HIV-1 IN. catechol 38-46 protein tyrosine phosphatase receptor type C Homo sapiens 17-21 19077667-1 2009 Human catechol-O-methyltransferase (COMT; EC 2.1.1.6) catalyzes the transfer of the methyl group to a variety of endogenous and exogenous catechol substrates using S-adenosyl-L-methionine as the methyl donor. catechol 6-14 catechol-O-methyltransferase Homo sapiens 36-40 19020775-1 2008 Human catechol-O-methyltransferase (COMT, EC 2.1.1.6) catalyzes the transfer of the methyl group to a variety of endogenous and exogenous catechol substrates using S-adenosyl-L-methionine as the methyl donor. catechol 6-14 catechol-O-methyltransferase Homo sapiens 36-40 19365560-1 2009 Catechol-O-methyltransferase (COMT) is an enzyme that plays a key role in the modulation of catechol-dependent functions such as cognition, cardiovascular function, and pain processing. catechol 92-100 catechol-O-methyltransferase Homo sapiens 0-28 19365560-1 2009 Catechol-O-methyltransferase (COMT) is an enzyme that plays a key role in the modulation of catechol-dependent functions such as cognition, cardiovascular function, and pain processing. catechol 92-100 catechol-O-methyltransferase Homo sapiens 30-34 19095062-5 2009 Enzyme kinetic analyses showed that chlorogenic acid and caffeic acid inhibited the human liver and placental COMT-mediated O-methylation of catechol estrogens with a mixed mechanism of inhibition (competitive plus noncompetitive). catechol 141-149 catechol-O-methyltransferase Homo sapiens 110-114 19095062-6 2009 Computational molecular modeling analysis showed that chlorogenic acid and caffeic acid can bind to human soluble COMT at the active site in a similar manner as the catechol estrogen substrates. catechol 165-173 catechol-O-methyltransferase Homo sapiens 114-118 18761407-8 2008 The high fat/low fiber diet was associated with high values both for catechol and 16alpha-hydroxylated estrogens and a high 2-hydroxyestrone/4-hydroxyestrone ratio, but 2-hydroxyestrone/16alpha-hydroxyestrone ratio was not different between the groups. catechol 69-77 FAT atypical cadherin 1 Homo sapiens 9-12 17805313-2 2008 Catechol-O-methyltransferase (COMT), which metabolizes catechol compounds, notably dopamine, is a leading candidate. catechol 55-63 catechol-O-methyltransferase Homo sapiens 0-28 17805313-2 2008 Catechol-O-methyltransferase (COMT), which metabolizes catechol compounds, notably dopamine, is a leading candidate. catechol 55-63 catechol-O-methyltransferase Homo sapiens 30-34 19198139-6 2008 (3) The catechol-derived quinones are candidate molecules to facilitate the oligomer formation of a-synuclein. catechol 8-16 synuclein alpha Homo sapiens 98-109 18562201-5 2008 These results indicate that the catechol fragment is critical for the D(2) receptor binding of the anti-parkinsonian drug, APO ((-)-1), but not necessary for binding at the D(1) and 5-HT(1A) receptors. catechol 32-40 Fas cell surface death receptor Homo sapiens 123-133 18702503-6 2008 Typical examples of all three classes of serine beta-lactamases (the class A TEM-2, class C P99, and class D OXA-1 enzymes) were competitively inhibited by the 1:1 vanadate-catechol complexes. catechol 173-181 RASD family member 2 Homo sapiens 77-82 18702503-6 2008 Typical examples of all three classes of serine beta-lactamases (the class A TEM-2, class C P99, and class D OXA-1 enzymes) were competitively inhibited by the 1:1 vanadate-catechol complexes. catechol 173-181 OXA1L mitochondrial inner membrane protein Homo sapiens 109-114 18768317-0 2008 Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening. catechol 17-25 signal transducer and activator of transcription 3 Homo sapiens 49-54 18768317-2 2008 We report here the identification of the catechol (1,2-dihydroxybenzene) structural moiety by virtual screening as a Stat3 SH2 inhibitor. catechol 41-49 signal transducer and activator of transcription 3 Homo sapiens 117-122 18768317-2 2008 We report here the identification of the catechol (1,2-dihydroxybenzene) structural moiety by virtual screening as a Stat3 SH2 inhibitor. catechol 51-71 signal transducer and activator of transcription 3 Homo sapiens 117-122 18768317-3 2008 The catechol compound docked to the Stat3 SH2 domain in computer modeling forms hydrogen bonds with the conserved pTyr-interacting amino acids. catechol 4-12 signal transducer and activator of transcription 3 Homo sapiens 36-41 18768317-4 2008 In the biochemical assay, a catechol-containing compound, but not the hydroxyl group-acetalized analogue, was able to inhibit Stat3 DNA-binding activity. catechol 28-36 signal transducer and activator of transcription 3 Homo sapiens 126-131 18768317-5 2008 Furthermore, the catechol compound was demonstrated to compete with pTyr peptides in binding to the Stat3 SH2 domain, suggesting that the catechol moiety is a pTyr bioisostere and may potentially be used for designing cell-permeable SH2 inhibitors. catechol 17-25 signal transducer and activator of transcription 3 Homo sapiens 100-105 18768317-5 2008 Furthermore, the catechol compound was demonstrated to compete with pTyr peptides in binding to the Stat3 SH2 domain, suggesting that the catechol moiety is a pTyr bioisostere and may potentially be used for designing cell-permeable SH2 inhibitors. catechol 138-146 signal transducer and activator of transcription 3 Homo sapiens 100-105 18768317-6 2008 In our preliminary effort, we also demonstrated that the potency of catechol compound as Stat3 SH2 inhibitors could be improved by modifying the non-catechol part of the compound structure. catechol 68-76 signal transducer and activator of transcription 3 Homo sapiens 89-94 18768317-6 2008 In our preliminary effort, we also demonstrated that the potency of catechol compound as Stat3 SH2 inhibitors could be improved by modifying the non-catechol part of the compound structure. catechol 149-157 signal transducer and activator of transcription 3 Homo sapiens 89-94 18270997-1 2008 Catechol-O-methyltransferase (COMT) catalyzes the breakdown of catechol neurotransmitters, including dopamine, which plays a prominent role in drug reward. catechol 63-71 catechol-O-methyltransferase Homo sapiens 0-28 18270997-1 2008 Catechol-O-methyltransferase (COMT) catalyzes the breakdown of catechol neurotransmitters, including dopamine, which plays a prominent role in drug reward. catechol 63-71 catechol-O-methyltransferase Homo sapiens 30-34 18610999-5 2008 The structure-activity relationship assessment of the PTK inhibitory potency of hematoxylin analogues isolated from Heamatoxylon campechianum was in good agreement with the result of concurrent molecular docking simulation: the catechol moiety in ring A and the hematoxylin-like three-dimensional structure were essential for c-Src-targeted activities. catechol 228-236 EPH receptor A8 Homo sapiens 54-57 18474266-4 2008 COMT contains two tryptophan residues, W143 and W38Y, which are located in loops that border the S-adenosylmethionine (SAM) and catechol binding sites. catechol 128-136 catechol-O-methyltransferase Homo sapiens 0-4 18618478-6 2008 HepG2 cells converted the catechol and methoxy metabolites of E2 to the respective E1 metabolites by 17beta-hydroxysteroid dehydrogenase (HSD). catechol 26-34 hydroxysteroid 17-beta dehydrogenase 13 Homo sapiens 101-136 19138946-3 2008 Genotoxicity may be caused by cytochrome P450 (CYP)-mediated oxidation of catechol estrogens to quinones that react with DNA to form depurinating estrogen-DNA adducts. catechol 74-82 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 30-45 19138946-3 2008 Genotoxicity may be caused by cytochrome P450 (CYP)-mediated oxidation of catechol estrogens to quinones that react with DNA to form depurinating estrogen-DNA adducts. catechol 74-82 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 47-50 18618478-10 2008 Thus, metabolism by COMT and UGT and, to a minor extent, by HSD is a major determinant for the genotoxicity of catechol estrogens in target cells. catechol 111-119 catechol-O-methyltransferase Homo sapiens 20-24 18618478-10 2008 Thus, metabolism by COMT and UGT and, to a minor extent, by HSD is a major determinant for the genotoxicity of catechol estrogens in target cells. catechol 111-119 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 29-32 18473748-0 2008 Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk. catechol 22-30 catechol-O-methyltransferase Homo sapiens 60-88 18486144-1 2008 Catechol O-methyltransferase (COMT) plays important roles in the metabolism of catecholamine neurotransmitters and catechol estrogens. catechol 79-87 catechol-O-methyltransferase Homo sapiens 0-28 18486144-1 2008 Catechol O-methyltransferase (COMT) plays important roles in the metabolism of catecholamine neurotransmitters and catechol estrogens. catechol 79-87 catechol-O-methyltransferase Homo sapiens 30-34 18512969-3 2008 The reaction leads to two catechol estrogen quinones, CE1-2,3-Q and CE1-3,4-Q, both of which react via Michael additions to afford 4-OH-E1-1-N3Ade and other DNA adducts. catechol 26-34 carboxylesterase 1 Homo sapiens 54-57 18512969-3 2008 The reaction leads to two catechol estrogen quinones, CE1-2,3-Q and CE1-3,4-Q, both of which react via Michael additions to afford 4-OH-E1-1-N3Ade and other DNA adducts. catechol 26-34 carboxylesterase 1 Homo sapiens 68-71 18407675-2 2008 The primary metabolite of PH-302 is a catechol ( 2) resulting from oxidative demethylenation of the methylenedioxyphenyl moiety by cytochrome P450 3A4. catechol 38-46 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 131-150 18473748-0 2008 Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk. catechol 22-30 estrogen receptor 1 Homo sapiens 108-125 18473748-2 2008 Catechol metabolites of PCBs are potent inhibitors of COMT activity and are likely to contribute significantly to reduced clearance of genotoxic catechol metabolites of estrogen. catechol 0-8 catechol-O-methyltransferase Homo sapiens 54-58 18473748-3 2008 The effect of PCB metabolites on COMT expression in cultured cells was investigated to explore potential mechanisms by which PCB exposure alters catechol estrogen clearance. catechol 145-153 pyruvate carboxylase Homo sapiens 125-128 18473748-6 2008 Western blot analysis demonstrated that COMT protein levels were statistically significantly reduced by both the phenolic and the catechol compounds, an effect which was abolished by the anti-estrogen, ICI182780. catechol 130-138 catechol-O-methyltransferase Homo sapiens 40-44 18473748-8 2008 It supports the hypothesis that both phenolic and catechol metabolites of PCBs may contribute to PCB-mediated carcinogenesis through reduction of COMT levels and activities and subsequent reduction in clearance of endogenous and xenobiotic catechols. catechol 50-58 pyruvate carboxylase Homo sapiens 74-77 18473748-8 2008 It supports the hypothesis that both phenolic and catechol metabolites of PCBs may contribute to PCB-mediated carcinogenesis through reduction of COMT levels and activities and subsequent reduction in clearance of endogenous and xenobiotic catechols. catechol 50-58 catechol-O-methyltransferase Homo sapiens 146-150 18065472-11 2008 Catechol binds deeper into the protein cavity compared to the other ligands, making contact with TM5 and TM6. catechol 0-8 tropomyosin 3 Homo sapiens 97-100 18079363-0 2008 Modulation of human multidrug resistance protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) transport activities by endogenous and exogenous glutathione-conjugated catechol metabolites. catechol 154-162 ATP binding cassette subfamily C member 1 Homo sapiens 20-56 18079363-0 2008 Modulation of human multidrug resistance protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) transport activities by endogenous and exogenous glutathione-conjugated catechol metabolites. catechol 154-162 ATP binding cassette subfamily C member 1 Homo sapiens 58-63 18079363-0 2008 Modulation of human multidrug resistance protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) transport activities by endogenous and exogenous glutathione-conjugated catechol metabolites. catechol 154-162 ATP binding cassette subfamily C member 2 Homo sapiens 69-73 18079363-0 2008 Modulation of human multidrug resistance protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) transport activities by endogenous and exogenous glutathione-conjugated catechol metabolites. catechol 154-162 ATP binding cassette subfamily C member 2 Homo sapiens 75-80 18199444-2 2008 Although all the compounds studied showed enhanced fluorescence after photolysis, there were large differences in the absolute level, with the inherent response of the catechol CA1 being much lower than the corresponding phenolic CA4. catechol 168-176 carbonic anhydrase 1 Homo sapiens 177-180 18194538-2 2008 Estrogens are metabolized by a series of enzymes including COMT, which converts catechol estrogens into biologically non-hazardous methoxyestrogens. catechol 80-88 catechol-O-methyltransferase Homo sapiens 59-63 18192686-3 2008 In the mammary gland, catechol estrogens are predominately inactivated by catechol-O-methyltransferase (COMT). catechol 22-30 catechol-O-methyltransferase Homo sapiens 74-102 18192686-3 2008 In the mammary gland, catechol estrogens are predominately inactivated by catechol-O-methyltransferase (COMT). catechol 22-30 catechol-O-methyltransferase Homo sapiens 104-108 18506224-6 2008 The K(m) values of the PPO for caffeic acid, chlorogenic acid, pyrocatechol, 4-methyl catechol and l-DOPA as substrates were 0.077, 0.198, 1.176, 1.667 and 4.545 mM. catechol 63-75 polyphenol oxidase I, chloroplastic Triticum aestivum 23-26 17907785-4 2007 In the present study, we have systematically assessed the NADPH-dependent covalent binding of [(3)H]paroxetine to human liver microsomes and S-9 preparations in the absence and presence of cofactors of the various phase II drug-metabolizing enzymes involved in the downstream metabolism/detoxification of the putative paroxetine-catechol intermediate. catechol 329-337 2,4-dienoyl-CoA reductase 1 Homo sapiens 58-63 17964424-4 2007 Catechol-O-methyltransferase (COMT) is considered an important enzyme that protects cells from the genotoxicity and cytotoxicity of catechol estrogens, by preventing their conversion to quinones. catechol 132-140 catechol-O-methyltransferase Homo sapiens 0-28 17964424-4 2007 Catechol-O-methyltransferase (COMT) is considered an important enzyme that protects cells from the genotoxicity and cytotoxicity of catechol estrogens, by preventing their conversion to quinones. catechol 132-140 catechol-O-methyltransferase Homo sapiens 30-34 17964424-9 2007 The COMT inhibitor Ro41-0960 blocked the methoxylation of catechol estrogens, with concomitant 3- to 4-fold increases in the levels of the depurinating adducts. catechol 58-66 catechol-O-methyltransferase Homo sapiens 4-8 17785456-4 2007 Molecular and biochemical approaches were employed to evaluate the mechanism of catechol-alpha-syn interactions and the effect on inclusion formation. catechol 80-88 synuclein alpha Homo sapiens 89-98 17891425-1 2007 The mechanism for the oxidation of catechol by catechol oxidase has been studied using B3LYP hybrid density functional theory. catechol 35-43 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 89-92 17785456-8 2007 These results suggest that inappropriate C-terminal cleavage of alpha-syn, which is known to occur in vivo in PD brain or a decline of intracellular catechol levels might affect disease progression, resulting in accelerated alpha-syn inclusion formation and dopaminergic neurodegeneration. catechol 149-157 synuclein alpha Homo sapiens 64-73 17724020-6 2007 These active tyrphostins all contain a catechol moiety and are good substrates for recombinant and endogenous catechol-O-methyltransferase. catechol 39-47 catechol-O-methyltransferase Homo sapiens 110-138 17716620-2 2007 In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, which contain a catechol moiety, inhibit tyrosinase-induced formation of 5-S-cysteinyl-dopamine via their capacity to undergo tyrosinase-induced oxidation to yield cysteinyl-polyphenol adducts. catechol 99-107 tyrosinase Homo sapiens 124-134 17716620-2 2007 In the present study, we show that the polyphenols, (+)-catechin and caffeic acid, which contain a catechol moiety, inhibit tyrosinase-induced formation of 5-S-cysteinyl-dopamine via their capacity to undergo tyrosinase-induced oxidation to yield cysteinyl-polyphenol adducts. catechol 99-107 tyrosinase Homo sapiens 209-219 17907785-12 2007 Inclusion of the catechol-O-methyltransferase cofactor S-adenosylmethionine (SAM) in S-9 incubations also dramatically reduced the covalent binding of [(3)H]paroxetine, a finding that was consistent with O-methylation of the paroxetine-catechol metabolite to the corresponding guaiacol regioisomers in S-9 incubations. catechol 17-25 ribosomal protein S9 Homo sapiens 85-88 17907785-12 2007 Inclusion of the catechol-O-methyltransferase cofactor S-adenosylmethionine (SAM) in S-9 incubations also dramatically reduced the covalent binding of [(3)H]paroxetine, a finding that was consistent with O-methylation of the paroxetine-catechol metabolite to the corresponding guaiacol regioisomers in S-9 incubations. catechol 17-25 ribosomal protein S9 Homo sapiens 302-305 17760745-2 2007 Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens. catechol 67-75 catechol-O-methyltransferase Homo sapiens 0-28 17850508-3 2007 Based on existing research, we propose that vitiligo has a multi-factorial etiology, characterized by multiple steps, but always involving an increase of external or internal phenol/catechol concentration, serving as a preferred surrogate substrate of tyrosinase, competing with its physiological substrate tyrosine. catechol 182-190 tyrosinase Homo sapiens 252-262 17537626-0 2007 Quaternary ammonium functionalized clay film electrodes modified with polyphenol oxidase for the sensitive detection of catechol. catechol 120-128 protoporphyrinogen oxidase Homo sapiens 70-88 19071865-2 2007 The stable SGC/TiO(2) electrode detects catechol, a neurotransmitter, in the presence of ascorbic acid, a common interferent, using cyclic voltammetry. catechol 40-48 sarcoglycan beta Homo sapiens 11-14 19071865-3 2007 A possible rationale for the stable catechol detection of SGC/TiO(2) electrode is attributed to most likely the adsorption of catechol onto highly porous TiO(2) (surface area of 147m(2)g(-1) and porosity of 46.2%), and the formation of C(6)H(4)(OTi)(2) bond between catechol and TiO(2). catechol 36-44 sarcoglycan beta Homo sapiens 58-61 19071865-3 2007 A possible rationale for the stable catechol detection of SGC/TiO(2) electrode is attributed to most likely the adsorption of catechol onto highly porous TiO(2) (surface area of 147m(2)g(-1) and porosity of 46.2%), and the formation of C(6)H(4)(OTi)(2) bond between catechol and TiO(2). catechol 126-134 sarcoglycan beta Homo sapiens 58-61 19071865-3 2007 A possible rationale for the stable catechol detection of SGC/TiO(2) electrode is attributed to most likely the adsorption of catechol onto highly porous TiO(2) (surface area of 147m(2)g(-1) and porosity of 46.2%), and the formation of C(6)H(4)(OTi)(2) bond between catechol and TiO(2). catechol 126-134 sarcoglycan beta Homo sapiens 58-61 19071865-4 2007 The catechol absorbed onto TiO(2) rapidly reaches the SGC surface, then is oxidized, involving two electrons (e(-)) and two protons (H(+)). catechol 4-12 sarcoglycan beta Homo sapiens 54-57 19071865-5 2007 As a result, the surface of TiO(2) acts as an electron-transfer accelerator between the SGC electrode and catechol. catechol 106-114 sarcoglycan beta Homo sapiens 88-91 19071865-6 2007 In addition to the quantitative and qualitative detection of catechol, the SGC/TiO(2) electrode developed here meets the profitable features of electrode including mechanical stability, physical rigidity, and enhanced catalytic properties. catechol 61-69 sarcoglycan beta Homo sapiens 75-78 17880176-1 2007 Catechol-O-methyltransferase (COMT, EC 2.1.1.6) catalyzes the O-methylation of a wide array of catechol-containing substrates using s-adenosyl-L-methionine as the methyl donor. catechol 95-103 catechol-O-methyltransferase Homo sapiens 0-28 17880176-1 2007 Catechol-O-methyltransferase (COMT, EC 2.1.1.6) catalyzes the O-methylation of a wide array of catechol-containing substrates using s-adenosyl-L-methionine as the methyl donor. catechol 95-103 catechol-O-methyltransferase Homo sapiens 30-34 17880176-2 2007 In the present study, we have cloned and expressed the human soluble and membrane-bound COMTs (S-COMT and MB-COMT, respectively) in Escherichia coli and have studied their biochemical characteristics for the O-methylation of representative classes of endogenous catechol substrates (catecholamines and catechol estrogens) as well as exogenous catechol substrates (bioflavonoids and tea catechins). catechol 262-270 catechol-O-methyltransferase Homo sapiens 88-92 17880176-2 2007 In the present study, we have cloned and expressed the human soluble and membrane-bound COMTs (S-COMT and MB-COMT, respectively) in Escherichia coli and have studied their biochemical characteristics for the O-methylation of representative classes of endogenous catechol substrates (catecholamines and catechol estrogens) as well as exogenous catechol substrates (bioflavonoids and tea catechins). catechol 283-291 catechol-O-methyltransferase Homo sapiens 88-92 17880176-2 2007 In the present study, we have cloned and expressed the human soluble and membrane-bound COMTs (S-COMT and MB-COMT, respectively) in Escherichia coli and have studied their biochemical characteristics for the O-methylation of representative classes of endogenous catechol substrates (catecholamines and catechol estrogens) as well as exogenous catechol substrates (bioflavonoids and tea catechins). catechol 283-291 catechol-O-methyltransferase Homo sapiens 88-92 17537626-2 2007 High sensitivity of the electrochemical device to catechol biosensing can be achieved when the enzyme was impregnated within the organoclay film subsequent to its deposition due to favorable electrostatic interaction between PPO and the TMPA-clay layer. catechol 50-58 protoporphyrinogen oxidase Homo sapiens 225-228 17768713-0 2007 Oxidation and chemiluminescence of catechol by hydrogen peroxide in the presence of Co(II) ions and CTAB micelles. catechol 35-43 mitochondrially encoded cytochrome c oxidase II Homo sapiens 84-90 17768713-1 2007 The oxidation of catechol in neutral and slightly alkaline aqueous solutions (pH 7-9.6) by excess hydrogen peroxide (0.002-0.09 mol/L) in the presence of Co(II) (2.10(-7)-2.10(-5) mol/L) is accompanied by abrupt formation of red purple colouration, which is subsequently decolourized within 1 h. The electron spectra of the reaction mixture are characterized by a broad band covering the whole visible range (400-700 nm), with maximum at 485 nm. catechol 17-25 mitochondrially encoded cytochrome c oxidase II Homo sapiens 154-160 17467970-4 2007 Constant reference has been made to the amperometric signals obtained, under the same experimental conditions, towards the catechol, a specific phenolic substrate for tyrosinase. catechol 123-131 tyrosinase Homo sapiens 167-177 17651437-2 2007 Polyphenol oxidase (PPO) catalyzes the oxidation of o-diphenols to their respective quinones. catechol 52-63 protoporphyrinogen oxidase Homo sapiens 0-18 17651437-2 2007 Polyphenol oxidase (PPO) catalyzes the oxidation of o-diphenols to their respective quinones. catechol 52-63 protoporphyrinogen oxidase Homo sapiens 20-23 17504906-2 2007 An example is catechol-O-methyltransferase (COMT), an estrogen-degrading enzyme involved in inactivation of catechol-estrogens. catechol 14-22 catechol-O-methyltransferase Homo sapiens 44-48 17847704-6 2007 Moreover, in the present kinetic study, we show that tyrosinase is not inhibited by an excess of monophenol, although, to confirm this, the system must be allowed to pass from the transition state and enter the steady-state, which is attained when a given amount of o-diphenol has accumulated in the medium. catechol 266-276 tyrosinase Homo sapiens 53-63 17760745-2 2007 Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens. catechol 67-75 catechol-O-methyltransferase Homo sapiens 30-34 16973425-4 2007 First, 3mm chromatographic paper was immersed in 0.5% (w/v) catechol solution as an immobilized PPO substrate. catechol 60-68 polyphenol oxidase B, chloroplastic Solanum lycopersicum 96-99 17417695-2 2007 Under optimized conditions (formaldehyde 20 mg/ml, PPO 4 mg/ml and pH 7.0), the activity of immobilized PPO was 1370 U/g and its Km value for catechol was 12 mM at 25 degrees C. The highest activity of immobilized enzyme was at pH 7.4. catechol 142-150 catechol oxidase B, chloroplastic Solanum tuberosum 104-107 17672292-0 2007 [Cloning and expression of catA gene from Pseudomonas putida ND6 and study on the catechol cleavage pathway]. catechol 82-90 catA Pseudomonas putida ND6 27-31 17507616-7 2007 These results support the hypothesis that the formation and accumulation of catechol estrogens in breast tissue through increased CYP1B1 expression and reduced COMT expression may play a significant role in breast cancer risk. catechol 76-84 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 130-136 17507616-7 2007 These results support the hypothesis that the formation and accumulation of catechol estrogens in breast tissue through increased CYP1B1 expression and reduced COMT expression may play a significant role in breast cancer risk. catechol 76-84 catechol-O-methyltransferase Homo sapiens 160-164 17230533-6 2007 In addition, both catechol estrogens induced P53 protein expression and apoptosis. catechol 18-26 cellular tumor antigen p53 Mesocricetus auratus 45-48 17230533-7 2007 The frequencies of apoptotic cells induced by the catechol estrogens were modified by the COMT inhibition in a manner similar to those observed with the chromosome aberrations assay and the cell transformation assay, indicating that each effect by the catechol estrogens at the three measured endpoints might be caused by a mechanism similar to the others. catechol 50-58 catechol O-methyltransferase Mesocricetus auratus 90-94 17230533-8 2007 Our findings indicate that COMT activity has an influence on cell transforming activity and its related genetic effects of catechol estrogens in SHE cells, which implies that an individual activity of COMT may be one of the etiological factors in endogenous estrogen-induced carcinogenesis. catechol 123-131 catechol O-methyltransferase Mesocricetus auratus 27-31 17230533-8 2007 Our findings indicate that COMT activity has an influence on cell transforming activity and its related genetic effects of catechol estrogens in SHE cells, which implies that an individual activity of COMT may be one of the etiological factors in endogenous estrogen-induced carcinogenesis. catechol 123-131 catechol O-methyltransferase Mesocricetus auratus 201-205 19071830-2 2007 The electrochemical biosensor functioning was based on the inhibition effect of benzoic acid on the biocatalytic activity of the polyphenol oxidase (PPO) to its substrate (catechol) in 0.1M phosphate buffer solution (pH 6.5). catechol 172-180 protoporphyrinogen oxidase Homo sapiens 129-147 19071830-2 2007 The electrochemical biosensor functioning was based on the inhibition effect of benzoic acid on the biocatalytic activity of the polyphenol oxidase (PPO) to its substrate (catechol) in 0.1M phosphate buffer solution (pH 6.5). catechol 172-180 protoporphyrinogen oxidase Homo sapiens 149-152 17507108-6 2007 The compounds identified through this method belonged to both hydroxamate and catechol-types, previously reported to cause color change of the CAS medium from blue to orange and purple, respectively. catechol 78-86 BCAR1 scaffold protein, Cas family member Homo sapiens 143-146 17570247-0 2007 Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. catechol 47-55 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 17570247-11 2007 These experiments demonstrated that CYP1A1, CYP1B1, and CYP3A4 are able to oxidize catechol estrogens to their respective quinones, which can further react with GSH, protein, and DNA, the last resulting in depurinating adducts that can lead to mutagenesis. catechol 83-91 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 17570247-11 2007 These experiments demonstrated that CYP1A1, CYP1B1, and CYP3A4 are able to oxidize catechol estrogens to their respective quinones, which can further react with GSH, protein, and DNA, the last resulting in depurinating adducts that can lead to mutagenesis. catechol 83-91 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 44-50 17570247-11 2007 These experiments demonstrated that CYP1A1, CYP1B1, and CYP3A4 are able to oxidize catechol estrogens to their respective quinones, which can further react with GSH, protein, and DNA, the last resulting in depurinating adducts that can lead to mutagenesis. catechol 83-91 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 56-62 17187958-2 2007 Since minipigs have been proposed as a suitable model species in toxicological and pharmacological research, the aim of this study was to explore mechanisms by which catechol, 1,4-hydroquinone and 1,4-benzoquinone destroy cytochrome P450 (P450) and induce oxidative stress in minipig liver microsomes. catechol 166-174 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 222-237 17234188-0 2007 Role of Neu4L sialidase and its substrate ganglioside GD3 in neuronal apoptosis induced by catechol metabolites. catechol 91-99 GRDX Homo sapiens 54-57 17379263-4 2007 The active constituents were identified as 3-hydroxyphloretin (7) and catechol (9); they exhibited potent hydroxyl radical-scavenging (IC(50) values, 0.6 and 1.1 microM) and cellular tyrosinase-reducing activities (IC(50) values, 32 and 22 microM) in human epidermal melanocytes. catechol 70-78 tyrosinase Homo sapiens 183-193 17379263-9 2007 Thus, 3-hydroxyphloretin (7) and catechol (9) were the most active constituents from the Formosan apple; they exhibited anti-oxidant and tyrosinase reducing activities, suggesting their possible use as cosmetic agents. catechol 33-41 tyrosinase Homo sapiens 137-147 17593728-2 2007 Experimental results demonstrate that complexation of Fe(II) by catechol- and thiol-containing organic ligands leads to formation of highly reactive species that reduce RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) and related N-heterocyclic nitramine explosive compounds to formaldehyde and inorganic nitrogen byproducts. catechol 64-72 radixin Homo sapiens 169-172 17234188-3 2007 To elucidate the pathophysiological roles of Neu4L in the nervous system, we investigated the possible involvement of Neu4L in the apoptotic neurodegeneration under the existence of catechol metabolites generated by tyrosinase. catechol 182-190 tyrosinase Homo sapiens 216-226 17305492-8 2007 Dicoumarol, a specific inhibitor of the NAD(P)H dependent quinone oxidoreductase (NQO1), significantly inhibited the metabolic elimination of TS in a noncompetitive way, suggesting that NQO1 was responsible for the quinone reduction of TS to form the catechol intermediate. catechol 251-259 crystallin zeta Rattus norvegicus 58-80 17305492-8 2007 Dicoumarol, a specific inhibitor of the NAD(P)H dependent quinone oxidoreductase (NQO1), significantly inhibited the metabolic elimination of TS in a noncompetitive way, suggesting that NQO1 was responsible for the quinone reduction of TS to form the catechol intermediate. catechol 251-259 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 82-86 17305492-8 2007 Dicoumarol, a specific inhibitor of the NAD(P)H dependent quinone oxidoreductase (NQO1), significantly inhibited the metabolic elimination of TS in a noncompetitive way, suggesting that NQO1 was responsible for the quinone reduction of TS to form the catechol intermediate. catechol 251-259 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 186-190 17061841-8 2006 The pH optima for wheat grass peroxidase to catalyze the oxidation of o-phenylenediamine (OPD), catechol, pyrogallol, and guaiacol were 5.0, 4.5, 6.5, and 5.0, respectively. catechol 96-104 peroxidase-like Triticum aestivum 30-40 17636223-1 2007 The catechol-O-methyltransferase (COMT) gene encodes enzymes that inactivate catechol estrogens and may have a protective role in estrogen-induced tumorigenesis, such as uterine leiomyoma (fibroids). catechol 4-12 catechol-O-methyltransferase Homo sapiens 34-38 17234793-4 2007 CYP1B1 oxidized E2 to the catechol 4-OHE2 and the labile quinone 4-hydroxyestradiol-quinone to produce 4-OHE2-N7-Gua and 4-OHE2-N3-Ade in a time- and concentration-dependent manner. catechol 26-34 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 17220335-2 2007 To counteract the effects of this catechol-estrogen, the catechol-O-methyltransferase (COMT) enzyme is capable of neutralizing the genotoxic effects of this compound. catechol 34-42 catechol-O-methyltransferase Homo sapiens 57-85 17220335-2 2007 To counteract the effects of this catechol-estrogen, the catechol-O-methyltransferase (COMT) enzyme is capable of neutralizing the genotoxic effects of this compound. catechol 34-42 catechol-O-methyltransferase Homo sapiens 87-91 17182830-5 2007 Catechol polyphenols may indirectly inhibit DNMT by generating S-adenosyl-L-homocysteine on their methylation by S-adenosyl-L-methionine. catechol 0-8 DNA methyltransferase 1 Homo sapiens 44-48 17407318-1 2007 Polyphenol oxidase (PPO; EC 1.14.18.1) catalyzes the hydroxylation of monophenols to o-diphenols (cresolase activity) and the oxidation of o-diphenols to o-quinones (catecholase activity), leading to browning in plants and produce. catechol 85-96 protoporphyrinogen oxidase Homo sapiens 0-18 17407318-1 2007 Polyphenol oxidase (PPO; EC 1.14.18.1) catalyzes the hydroxylation of monophenols to o-diphenols (cresolase activity) and the oxidation of o-diphenols to o-quinones (catecholase activity), leading to browning in plants and produce. catechol 85-96 protoporphyrinogen oxidase Homo sapiens 20-23 17407318-1 2007 Polyphenol oxidase (PPO; EC 1.14.18.1) catalyzes the hydroxylation of monophenols to o-diphenols (cresolase activity) and the oxidation of o-diphenols to o-quinones (catecholase activity), leading to browning in plants and produce. catechol 139-150 protoporphyrinogen oxidase Homo sapiens 0-18 17407318-1 2007 Polyphenol oxidase (PPO; EC 1.14.18.1) catalyzes the hydroxylation of monophenols to o-diphenols (cresolase activity) and the oxidation of o-diphenols to o-quinones (catecholase activity), leading to browning in plants and produce. catechol 139-150 protoporphyrinogen oxidase Homo sapiens 20-23 16807674-1 2007 Cytochrome P-450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogens and mammary carcinogens into 2-hydroxy catechol metabolites. catechol 117-125 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-20 16807674-1 2007 Cytochrome P-450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogens and mammary carcinogens into 2-hydroxy catechol metabolites. catechol 117-125 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 22-28 17425115-5 2007 Polyphenol oxidase activities with o-diphenolic substrates (caffeic acid, catechol and dopa) were found to be higher than with a monophenolic substrat (tyrosine) in both embryos and endosperms. catechol 74-82 Polyphenol oxidase, chloroplastic Zea mays 0-18 17146516-1 2006 The activities of the enzymes tyrosinase and thrombin are probed by the association of the ferrocene boronic acid label to the enzyme-generated catechol ligand, and by the cleavage of the ligand-redox complex tethered to a peptide, respectively. catechol 144-152 tyrosinase Homo sapiens 30-40 17146516-1 2006 The activities of the enzymes tyrosinase and thrombin are probed by the association of the ferrocene boronic acid label to the enzyme-generated catechol ligand, and by the cleavage of the ligand-redox complex tethered to a peptide, respectively. catechol 144-152 coagulation factor II, thrombin Homo sapiens 45-53 17061841-10 2006 Under optimal reaction conditions, wheat grass peroxidase catalyzed the oxidation of OPD (an aromatic amine substrate) 3-11 times more rapidly than guaiacol, catechol, and pyrogallol (phenolic substrates containing one to three hydroxy groups in the benzene ring). catechol 158-166 peroxidase-like Triticum aestivum 47-57 16880198-0 2006 Voltage-gated k+ channel block by catechol derivatives: defining nonselective and selective pharmacophores. catechol 34-42 potassium voltage-gated channel subfamily D member 3 Homo sapiens 0-24 16880198-1 2006 High-throughput screening led to the identification of a 3-norbornyl derivative of catechol called 48F10 (3-bicyclo[2.2.1]hept-2-yl-benzene-1,2-diol) as a Kv2.1 K(+) channel inhibitor. catechol 83-91 potassium voltage-gated channel subfamily B member 1 Homo sapiens 155-160 16880198-5 2006 We find that catechol (1,2-benzenediol), unlike 48F10, inhibits Kv2.1 currents with a Hill coefficient of 2 and slows channel activation. catechol 13-21 potassium voltage-gated channel subfamily B member 1 Homo sapiens 64-69 16880198-5 2006 We find that catechol (1,2-benzenediol), unlike 48F10, inhibits Kv2.1 currents with a Hill coefficient of 2 and slows channel activation. catechol 27-38 potassium voltage-gated channel subfamily B member 1 Homo sapiens 64-69 17047485-2 2006 Catechol-O-methyltransferase (COMT) is a phase II enzyme that inactivates catechol estrogens by transfer of a methyl group. catechol 74-82 catechol-O-methyltransferase Homo sapiens 0-28 17047485-2 2006 Catechol-O-methyltransferase (COMT) is a phase II enzyme that inactivates catechol estrogens by transfer of a methyl group. catechol 74-82 catechol-O-methyltransferase Homo sapiens 30-34 17018638-1 2006 Because catechol-O-methyltransferase (COMT) catalyzes the addition of methyl groups to stabilize catechol estrogens that may induce DNA damage, genetic variants could influence breast cancer risk. catechol 8-16 catechol-O-methyltransferase Homo sapiens 38-42 17005870-3 2006 To study this process and its association with neurodegeneration, intracellular catechol levels were increased to various levels by expressing different forms of tyrosine hydroxylase, in cells induced to form alpha-syn aggregates. catechol 80-88 synuclein, alpha Mus musculus 209-218 16957086-6 2006 In summary, we demonstrate that overexpression of different types of alpha-synuclein disrupts vesicular pH and leads to a marked increase in the levels of cytosolic catechol species, an effect that may in turn trigger cellular oxyradical damage. catechol 165-173 synuclein alpha Rattus norvegicus 69-84 16966822-0 2006 Application of the nanogold-4,4"-bis(methanethiol)biphenyl modified gold electrode to the determination of tyrosinase-catechol reaction kinetics in acetonitrile. catechol 118-126 tyrosinase Homo sapiens 107-117 16966822-1 2006 The reactivity of tyrosinase adsorbed on nanogold bound with 4,4"-bis(methanethiol)biphenyl monolayer self-assembled on a gold disk with catechol in a dipolar aprotic solvent, acetonitrile (AN), was studied by cyclic voltammetric and amperometric methods. catechol 137-145 tyrosinase Homo sapiens 18-28 16966822-4 2006 The apparent Michaelis-Menten constant K(m) of tyrosinase for catechol is 5.5 +/- 0.4 mM (n = 5). catechol 62-70 tyrosinase Homo sapiens 47-57 16423566-6 2006 As proved by the electrochemical and spectroelectrochemical (UV-VIS) experiments, tyrosinase covalently bonded to the polymer matrix effectively catalyzes oxidation of catechol. catechol 168-176 tyrosinase Homo sapiens 82-92 16470514-1 2006 The enzyme catechol-O-methyltransferase (COMT) plays an important role in the metabolism of catechol estrogens and degradation of the catecholamine neurotransmitters, such as epinephrine. catechol 11-19 catechol-O-methyltransferase Homo sapiens 41-45 16596327-1 2006 The gene encoding catechol-O-methyltransferase (COMT), critical to the inactivation of reactive catechol estrogens, has several single nucleotide polymorphisms (SNPs) that influence enzyme activity. catechol 18-26 catechol-O-methyltransferase Homo sapiens 48-52 19127746-6 2006 The inhibition mode was determined using Dixon and Lineweaver-Burk plots, which established SC to be a mixed inhibitor of apple PPO for the oxidation of catechol. catechol 153-161 polyphenol oxidase, chloroplastic Malus domestica 128-131 16712820-3 2006 However, specific COX-2 triggered mechanisms participating in catalysis of DA oxidation and enhanced catechol-induced cytotoxicity remain poorly characterized. catechol 101-109 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 18-23 16732514-9 2006 Determination of EGF receptor tyrosine kinase activity likewise revealed strong inhibition in the presence of a catechol group at ring B. catechol 112-120 epidermal growth factor Rattus norvegicus 17-20 20223014-1 2006 Catechol-O-methyltransferase (COMT) is vital for the conjugation of catechol estrogens that are produced during oestrogen metabolism. catechol 68-76 catechol-O-methyltransferase Homo sapiens 0-28 20223014-1 2006 Catechol-O-methyltransferase (COMT) is vital for the conjugation of catechol estrogens that are produced during oestrogen metabolism. catechol 68-76 catechol-O-methyltransferase Homo sapiens 30-34 16791731-1 2006 Cotton cellulose was dyed "in situ" with a polymeric dye generated by oxidative coupling of colourless 2,5-diaminobenzenesulfonic acid and 1-hydroxyphenol (catechol) with laccase. catechol 156-164 laccase-14-like Gossypium hirsutum 171-178 16719104-3 2006 In solutions containing FeII and tiron, a model catechol, rates of NAC reduction are heavily dependent on pH, ligand concentration, and ionic strength. catechol 48-56 X-linked Kx blood group Homo sapiens 67-70 16573647-8 2006 These data suggest that chronic depolarization of sympathetic neurons induces NET expression through increasing catecholamines, and that M17 neuroblastoma cells provide a model system in which to investigate catechol regulation of NET expression. catechol 112-120 solute carrier family 6 member 2 Homo sapiens 78-81 16634598-2 2006 The Fe(III)-binding constants and pH-dependent speciation parallel those of catechol in that mono, bis, and tris FeLx species are present at concentrations dependent on the pH. catechol 76-84 general transcription factor IIE subunit 1 Homo sapiens 7-10 16595935-2 2006 The PRY strain exhibited a robust swarming behavior and was able to digest human transferrin efficiently, concomitantly with the production of catechol-siderophore in the exponential growth phase. catechol 143-151 PTPN13 like Y-linked Homo sapiens 4-7 16567160-0 2006 Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson"s disease. catechol 53-61 synuclein alpha Homo sapiens 0-15 16253764-3 2005 This polymorphism has been the subject of intense molecular epidemiological studies because of the important role of COMT in the metabolism of catecholamines and catechol estrogens. catechol 143-151 catechol-O-methyltransferase Homo sapiens 117-121 17047300-4 2006 The catechol-derived quinones are the candidate molecules that facilitate the oligomer formation of alpha-synuclein. catechol 4-12 synuclein alpha Homo sapiens 100-115 16898270-10 2006 Assays of some of the compounds as substrates for tyrosinase showed that the catechol 18 was the best substrate and that the piperidine derivative 7 was the best substrate of the phenolic compounds synthesized. catechol 77-85 tyrosinase Homo sapiens 50-60 16551744-4 2006 The predicted structures for apo-beta2AR and butoxamine-beta2AR are stable in MD, but in epinephrine-beta2AR, extracellular water trickles into the binding pocket to mediate hydrogen bonding between the catechol of epinephrine and Ser-204 on helix 5. catechol 203-211 adrenoceptor beta 2 Homo sapiens 33-40 16551744-4 2006 The predicted structures for apo-beta2AR and butoxamine-beta2AR are stable in MD, but in epinephrine-beta2AR, extracellular water trickles into the binding pocket to mediate hydrogen bonding between the catechol of epinephrine and Ser-204 on helix 5. catechol 203-211 adrenoceptor beta 2 Homo sapiens 56-63 16551744-4 2006 The predicted structures for apo-beta2AR and butoxamine-beta2AR are stable in MD, but in epinephrine-beta2AR, extracellular water trickles into the binding pocket to mediate hydrogen bonding between the catechol of epinephrine and Ser-204 on helix 5. catechol 203-211 adrenoceptor beta 2 Homo sapiens 56-63 16146780-5 2006 In addition to direct effect of 17 beta-estradiol (E2) on mitochondria and redox cycling of catechol estrogens, E2-induced overexpression of IL-1 beta can produce an increase in the level of ROS. catechol 92-100 interleukin 1 beta Homo sapiens 141-150 16255612-5 2005 The air-brushed enzyme electrodes exhibited relevant bioelectrocatalytic activity toward catechol and glucose, with a linear detection range of 0.1-100 microM catechol and 0.5-7 mM glucose; the sensitivities were 2.41 A M(-1) cm(-2) and 2.98 mA M(-1) cm(-2) for Tyr and GOx electrodes, respectively. catechol 89-97 tyrosinase Homo sapiens 262-265 16838923-4 2005 Among the three potential sites of chelation present in the quercetin structure, the catechol function presents the highest complexation power toward Pb(II), in opposition with previous results found for Al(III) complexation. catechol 85-93 submaxillary gland androgen regulated protein 3B Homo sapiens 150-156 16255612-5 2005 The air-brushed enzyme electrodes exhibited relevant bioelectrocatalytic activity toward catechol and glucose, with a linear detection range of 0.1-100 microM catechol and 0.5-7 mM glucose; the sensitivities were 2.41 A M(-1) cm(-2) and 2.98 mA M(-1) cm(-2) for Tyr and GOx electrodes, respectively. catechol 89-97 hydroxyacid oxidase 1 Homo sapiens 270-273 16255612-5 2005 The air-brushed enzyme electrodes exhibited relevant bioelectrocatalytic activity toward catechol and glucose, with a linear detection range of 0.1-100 microM catechol and 0.5-7 mM glucose; the sensitivities were 2.41 A M(-1) cm(-2) and 2.98 mA M(-1) cm(-2) for Tyr and GOx electrodes, respectively. catechol 159-167 tyrosinase Homo sapiens 262-265 16255612-5 2005 The air-brushed enzyme electrodes exhibited relevant bioelectrocatalytic activity toward catechol and glucose, with a linear detection range of 0.1-100 microM catechol and 0.5-7 mM glucose; the sensitivities were 2.41 A M(-1) cm(-2) and 2.98 mA M(-1) cm(-2) for Tyr and GOx electrodes, respectively. catechol 159-167 hydroxyacid oxidase 1 Homo sapiens 270-273 16041399-9 2005 Structure-activity relationship analyses suggested that the catechol moiety and alpha,beta-unsaturated ester group in ethyl caffeate are important and essential structural features for preventing NF-kappaB.DNA complex formation. catechol 60-68 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 196-205 16283760-5 2005 In addition, biosensors were prepared by entrapment of the PPO in polypyrrole-alginate and regular alginate matrixes and their performance for the amperometric determination of catechol chosen as a model analyte was examined, yielding a sensitivity of 350 and 80 microA M(-1) cm(-2), respectively, for polypyrrole-alginate and alginate biosensors. catechol 177-185 protoporphyrinogen oxidase Homo sapiens 59-62 16175316-1 2005 Sulfotransferase (SULT) 1A1 is involved in the inactivation and elimination of estrogens and catechol estrogens. catechol 93-101 sulfotransferase family 1A member 1 Homo sapiens 0-27 16002297-1 2005 Bifunctional compounds were tested in vitro as potential inhibitors of pig liver catechol-O-methyltransferase (COMT) with respect to the catechol substrate 4-[(3,4-dihydroxyphenyl)azo]benzenesulfonate. catechol 81-89 catechol-O-methyltransferase Sus scrofa 111-115 16142378-3 2005 Among the key enzymes metabolizing estrogens are two activating enzymes: cytochrome P450 (CYP)19 (aromatase), which converts androgens to estrogens, and CYP1B1, which converts estrogens predominantly to the 4-catechol estrogens that are further oxidized to catechol estrogen-3,4-quinones. catechol 209-217 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 73-96 16142378-3 2005 Among the key enzymes metabolizing estrogens are two activating enzymes: cytochrome P450 (CYP)19 (aromatase), which converts androgens to estrogens, and CYP1B1, which converts estrogens predominantly to the 4-catechol estrogens that are further oxidized to catechol estrogen-3,4-quinones. catechol 209-217 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 153-159 16142378-5 2005 In addition, catechol estrogen quinones can be reduced back to catechol estrogens by NADPH quinone oxidoreductase 1 (NQO1) and/or are coupled with glutathione, preventing reaction with DNA. catechol 13-21 NAD(P)H quinone dehydrogenase 1 Homo sapiens 85-115 16142378-5 2005 In addition, catechol estrogen quinones can be reduced back to catechol estrogens by NADPH quinone oxidoreductase 1 (NQO1) and/or are coupled with glutathione, preventing reaction with DNA. catechol 13-21 NAD(P)H quinone dehydrogenase 1 Homo sapiens 117-121 16142378-5 2005 In addition, catechol estrogen quinones can be reduced back to catechol estrogens by NADPH quinone oxidoreductase 1 (NQO1) and/or are coupled with glutathione, preventing reaction with DNA. catechol 63-71 NAD(P)H quinone dehydrogenase 1 Homo sapiens 85-115 16142378-5 2005 In addition, catechol estrogen quinones can be reduced back to catechol estrogens by NADPH quinone oxidoreductase 1 (NQO1) and/or are coupled with glutathione, preventing reaction with DNA. catechol 63-71 NAD(P)H quinone dehydrogenase 1 Homo sapiens 117-121 15901486-9 2005 A pharmacological inhibitor of ERK aggravated the 4-OHE2-induced cytotoxicity, supporting the pivotal role of ERK in protecting against catechol estrogen-induced oxidative cell death. catechol 136-144 mitogen-activated protein kinase 1 Homo sapiens 31-34 15901486-9 2005 A pharmacological inhibitor of ERK aggravated the 4-OHE2-induced cytotoxicity, supporting the pivotal role of ERK in protecting against catechol estrogen-induced oxidative cell death. catechol 136-144 mitogen-activated protein kinase 1 Homo sapiens 110-113 15699049-1 2005 The Cu2+ complexes of the 1-16 and the 1-20 fragments of the Alzheimer"s disease-related beta-amyloid peptide (CuAbeta) show significant oxidative activities toward a catechol-like substrate trihydroxylbenzene and plasmid DNA cleavage. catechol 167-175 amyloid beta precursor protein Homo sapiens 89-109 16167833-0 2005 Tyrosinase-catalyzed oxidation of 17beta-estradiol: structure elucidation of the products formed beyond catechol estrogen quinones. catechol 104-112 tyrosinase Homo sapiens 0-10 16231197-3 2005 Analysis of agonist/alpha1A adrenoceptor complex interactions focused on the role of the charged amine group, the aromatic ring, the N-methyl group of adrenaline, the beta hydroxyl group and the catechol meta and para hydroxyl groups of the catecholamines. catechol 195-203 adrenoceptor alpha 1A Homo sapiens 20-40 15935814-4 2005 Using chicken erythroblast HD3 cells we have shown that exposure to the benzene metabolites catechol, benzoquinone, and hydroquinone leads to increased c-Myb activity, increased phosphorylation of c-Myb and increased production of ROS supporting our hypothesis. catechol 92-100 MYB proto-oncogene, transcription factor Gallus gallus 152-157 15935814-4 2005 Using chicken erythroblast HD3 cells we have shown that exposure to the benzene metabolites catechol, benzoquinone, and hydroquinone leads to increased c-Myb activity, increased phosphorylation of c-Myb and increased production of ROS supporting our hypothesis. catechol 92-100 MYB proto-oncogene, transcription factor Gallus gallus 197-202 15935814-7 2005 We have found that both wild type and AhR deficient cells are sensitive to catechol and hydroquinone-initiated increases in c-Myb activity while both cell types are resistant to benzene-initiated alterations leaving the role of the AhR still undetermined. catechol 75-83 aryl-hydrocarbon receptor Mus musculus 38-41 15935814-7 2005 We have found that both wild type and AhR deficient cells are sensitive to catechol and hydroquinone-initiated increases in c-Myb activity while both cell types are resistant to benzene-initiated alterations leaving the role of the AhR still undetermined. catechol 75-83 myeloblastosis oncogene Mus musculus 124-129 15935814-8 2005 Interestingly, protein expression of c-Myb is increased after catechol exposure in AhR deficient cells while decreased in wild-type cells. catechol 62-70 myeloblastosis oncogene Mus musculus 37-42 15935814-8 2005 Interestingly, protein expression of c-Myb is increased after catechol exposure in AhR deficient cells while decreased in wild-type cells. catechol 62-70 aryl-hydrocarbon receptor Mus musculus 83-86 15848247-2 2005 A catechol compound, 3,4-dihydroxybenzoic acid (3,4DOBA), was used as a highly fluorogenic substrate for COMT. catechol 2-10 catechol-O-methyltransferase Rattus norvegicus 105-109 16077979-1 2005 Polymorphic catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens. catechol 12-20 catechol-O-methyltransferase Homo sapiens 42-46 16052638-0 2005 Alzheimer"s disease related copper(II)- beta-amyloid peptide exhibits phenol monooxygenase and catechol oxidase activities. catechol 95-103 amyloid beta precursor protein Homo sapiens 40-60 16045352-4 2005 In this article we are reporting static and dynamic aspects of the enzyme catalysis in a bimolecular reaction, namely a methyl transfer from S-adenosylmethionine to the hydroxylate oxygen of a substituted catechol catalyzed by catechol O-methyltransferase. catechol 205-213 catechol-O-methyltransferase Homo sapiens 227-255 15817484-3 2005 In the present study, we use catechol (1,2-benzenediol, a structural component of catecholamine agonists) as a molecular probe to identify mechanistic differences between beta(2)AR activation by catecholamine agonists, such as isoproterenol, and by the structurally related non-catechol partial agonist salbutamol. catechol 29-37 adrenoceptor beta 2 Homo sapiens 171-180 15720130-0 2005 Induction of cytotoxicity, aldehydic DNA lesions, and poly(ADP-ribose) polymerase-1 activation by catechol derivatives of pentachlorophenol in calf thymus DNA and in human breast cancer cells. catechol 98-106 poly [ADP-ribose] polymerase 1 Bos taurus 54-83 15694844-7 2005 The biological response to catechol toxicity appears to rely on the pathway of NAD(P)H:quinone oxidoreductase 1 (NQO1). catechol 27-35 NAD(P)H quinone dehydrogenase 1 Homo sapiens 79-111 15694844-7 2005 The biological response to catechol toxicity appears to rely on the pathway of NAD(P)H:quinone oxidoreductase 1 (NQO1). catechol 27-35 NAD(P)H quinone dehydrogenase 1 Homo sapiens 113-117 16833529-5 2005 Both spectroscopic data and calculations reveal that Pb(II) preferentially coordinates with the carboxylate function, in opposition with previous results found for the Al(III) complexation, where the catechol group presents the greater complexing power. catechol 200-208 submaxillary gland androgen regulated protein 3B Homo sapiens 53-59 15686433-12 2005 The optimum pH values for PPO were 5.0, 8.0, and 7.0 using 4-methylcatechol, pyrogallol, and catechol as substrate, respectively. catechol 67-75 protoporphyrinogen oxidase Homo sapiens 26-29 15686433-15 2005 However, all inactivation experiments for catechol showed that the activity of artichoke PPO increased with mild heating, reached a maximum, and then decreased with time. catechol 42-50 protoporphyrinogen oxidase Homo sapiens 89-92 16158584-1 2005 Adsorption of catechol from aqueous solution with the hypercrosslinked polymeric adsorbent NDA-100 and its derivatives AH-1, AH-2 and AH-3 aminated by dimethylamine, the commercial resin Amberlite XAD-4 and weakly basic anion exchanger resin D301 was compared. catechol 14-22 zinc finger RANBP2-type containing 3 Homo sapiens 125-129 18969806-11 2005 The limit of detection for catechol using tyrosinase was equal to 0.35 and 1.7muM in the flow and steady state systems, respectively. catechol 27-35 tyrosinase Homo sapiens 42-52 15620894-2 2005 Phenol generated by the action of ALP is monitored at the tyrosinase composite electrode through the electrochemical reduction of the o-quinone produced to catechol, which produces a cycle between the tyrosinase substrate and the electroactive product, giving rise to the amplification of the biosensor response and to the sensitive detection of ALP. catechol 156-164 alkaline phosphatase, placental Homo sapiens 34-37 15620894-2 2005 Phenol generated by the action of ALP is monitored at the tyrosinase composite electrode through the electrochemical reduction of the o-quinone produced to catechol, which produces a cycle between the tyrosinase substrate and the electroactive product, giving rise to the amplification of the biosensor response and to the sensitive detection of ALP. catechol 156-164 tyrosinase Homo sapiens 58-68 15620894-2 2005 Phenol generated by the action of ALP is monitored at the tyrosinase composite electrode through the electrochemical reduction of the o-quinone produced to catechol, which produces a cycle between the tyrosinase substrate and the electroactive product, giving rise to the amplification of the biosensor response and to the sensitive detection of ALP. catechol 156-164 tyrosinase Homo sapiens 201-211 15620894-2 2005 Phenol generated by the action of ALP is monitored at the tyrosinase composite electrode through the electrochemical reduction of the o-quinone produced to catechol, which produces a cycle between the tyrosinase substrate and the electroactive product, giving rise to the amplification of the biosensor response and to the sensitive detection of ALP. catechol 156-164 alkaline phosphatase, placental Homo sapiens 346-349 16191465-1 2005 BACKGROUND: Polymorphic catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens, which are hypothesized to participate in estrogen-induced carcinogenesis. catechol 24-32 catechol-O-methyltransferase Homo sapiens 54-58 15541759-0 2004 The effects of benzene and the metabolites phenol and catechol on c-Myb and Pim-1 signaling in HD3 cells. catechol 54-62 MYB proto-oncogene, transcription factor Gallus gallus 66-71 15612812-9 2004 Then, a regenerated catechol moiety of adducts scavenge two additional radicals by reoxidation into quinones, which undergo the second nucleophilic attack at the C-5. catechol 20-28 complement C5 Homo sapiens 162-165 15645182-1 2005 Catechol-O-methyltransferase (COMT) inactivates circulating catechol hormones, catechol neurotransmitters, and xenobiotic catecholamines by methylating their catechol moieties. catechol 60-68 catechol-O-methyltransferase Homo sapiens 0-28 15645182-1 2005 Catechol-O-methyltransferase (COMT) inactivates circulating catechol hormones, catechol neurotransmitters, and xenobiotic catecholamines by methylating their catechol moieties. catechol 60-68 catechol-O-methyltransferase Homo sapiens 30-34 15645182-1 2005 Catechol-O-methyltransferase (COMT) inactivates circulating catechol hormones, catechol neurotransmitters, and xenobiotic catecholamines by methylating their catechol moieties. catechol 79-87 catechol-O-methyltransferase Homo sapiens 0-28 15645182-1 2005 Catechol-O-methyltransferase (COMT) inactivates circulating catechol hormones, catechol neurotransmitters, and xenobiotic catecholamines by methylating their catechol moieties. catechol 79-87 catechol-O-methyltransferase Homo sapiens 30-34 15645182-1 2005 Catechol-O-methyltransferase (COMT) inactivates circulating catechol hormones, catechol neurotransmitters, and xenobiotic catecholamines by methylating their catechol moieties. catechol 79-87 catechol-O-methyltransferase Homo sapiens 0-28 15645182-1 2005 Catechol-O-methyltransferase (COMT) inactivates circulating catechol hormones, catechol neurotransmitters, and xenobiotic catecholamines by methylating their catechol moieties. catechol 79-87 catechol-O-methyltransferase Homo sapiens 30-34 15541759-6 2004 Our results demonstrated that catechol exposure caused a time- and concentration-dependent increase in c-Myb activity with significance occurring at 100 and 300 microM after 24 h of exposure, which was independent of increased Pim-1 protein, but dependent on increased c-Myb phosphorylation. catechol 30-38 MYB proto-oncogene, transcription factor Gallus gallus 103-108 15541759-0 2004 The effects of benzene and the metabolites phenol and catechol on c-Myb and Pim-1 signaling in HD3 cells. catechol 54-62 Pim-1 proto-oncogene, serine/threonine kinase Gallus gallus 76-81 15541759-6 2004 Our results demonstrated that catechol exposure caused a time- and concentration-dependent increase in c-Myb activity with significance occurring at 100 and 300 microM after 24 h of exposure, which was independent of increased Pim-1 protein, but dependent on increased c-Myb phosphorylation. catechol 30-38 Pim-1 proto-oncogene, serine/threonine kinase Gallus gallus 227-232 15541759-6 2004 Our results demonstrated that catechol exposure caused a time- and concentration-dependent increase in c-Myb activity with significance occurring at 100 and 300 microM after 24 h of exposure, which was independent of increased Pim-1 protein, but dependent on increased c-Myb phosphorylation. catechol 30-38 MYB proto-oncogene, transcription factor Gallus gallus 269-274 15541759-0 2004 The effects of benzene and the metabolites phenol and catechol on c-Myb and Pim-1 signaling in HD3 cells. catechol 54-62 histone deacetylase 3 Gallus gallus 95-98 15541759-4 2004 In our study, we evaluated the effects of benzene and the metabolites catechol and phenol on c-Myb signaling to investigate our hypothesis that benzene exerts its toxicity by interfering with this pathway. catechol 70-78 MYB proto-oncogene, transcription factor Gallus gallus 93-98 15142886-2 2004 In our present study, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), when treated with the cultured human mammary epithelial (MCF-10A) cells, induced the expression of cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) that are responsible for the oxidation of 17beta-estradiol to produce catechol estrogens. catechol 281-289 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 165-184 15142886-6 2004 Our data suggest that CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a key role in TCDD-induced oxidative damage, and resveratrol can act as a potential chemopreventive against dioxin-induced human mammary carcinogenesis by blocking the metabolic formation of the catechol estrogens and scavenging the ROS generated during their redox cycling. catechol 51-59 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 22-28 15142886-6 2004 Our data suggest that CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a key role in TCDD-induced oxidative damage, and resveratrol can act as a potential chemopreventive against dioxin-induced human mammary carcinogenesis by blocking the metabolic formation of the catechol estrogens and scavenging the ROS generated during their redox cycling. catechol 51-59 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 34-40 15142886-6 2004 Our data suggest that CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a key role in TCDD-induced oxidative damage, and resveratrol can act as a potential chemopreventive against dioxin-induced human mammary carcinogenesis by blocking the metabolic formation of the catechol estrogens and scavenging the ROS generated during their redox cycling. catechol 285-293 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 22-28 15142886-6 2004 Our data suggest that CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a key role in TCDD-induced oxidative damage, and resveratrol can act as a potential chemopreventive against dioxin-induced human mammary carcinogenesis by blocking the metabolic formation of the catechol estrogens and scavenging the ROS generated during their redox cycling. catechol 285-293 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 34-40 15319341-2 2004 The cytochrome P450 (P450)-derived catechol and quinone metabolites of etoposide may be important in the damage to the MLL (mixed lineage leukemia) gene and other genes resulting in leukemia-associated chromosomal translocations. catechol 35-43 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 15-19 15254334-5 2004 Catechol-O-methyltransferase (COMT) converts the catechol estrogens to their inactive methoxy derivatives (2-MeOE(2) and 4-MeOE(2)). catechol 49-57 catechol-O-methyltransferase Homo sapiens 0-28 15254334-5 2004 Catechol-O-methyltransferase (COMT) converts the catechol estrogens to their inactive methoxy derivatives (2-MeOE(2) and 4-MeOE(2)). catechol 49-57 catechol-O-methyltransferase Homo sapiens 30-34 15254334-14 2004 This suggests that phytochemicals with a catechol structure have the potential to reduce COMT activity in mammary tissues and may consequently reduce the inactivation of potentially mutagenic estradiol metabolites and increase the chance of DNA damage. catechol 41-49 catechol-O-methyltransferase Homo sapiens 89-93 15319341-2 2004 The cytochrome P450 (P450)-derived catechol and quinone metabolites of etoposide may be important in the damage to the MLL (mixed lineage leukemia) gene and other genes resulting in leukemia-associated chromosomal translocations. catechol 35-43 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 21-25 15319341-2 2004 The cytochrome P450 (P450)-derived catechol and quinone metabolites of etoposide may be important in the damage to the MLL (mixed lineage leukemia) gene and other genes resulting in leukemia-associated chromosomal translocations. catechol 35-43 lysine methyltransferase 2A Homo sapiens 119-122 15319348-1 2004 Both UDP-glucuronosyltransferase 2B4 (UGT2B4) and UGT2B7 are expressed mainly in the human liver and have several overlapping substrates; e.g., catechol estrogens, bile acids, codeine, and carvedilol. catechol 144-152 UDP glucuronosyltransferase family 2 member B4 Homo sapiens 5-36 15319341-4 2004 CYP3A4 was found to play a major role in etoposide metabolism (K(m) = 77.7 +/- 27.8 microM; V(max) = 314 +/- 84 pmol of catechol/min/nmol of P450). catechol 120-128 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 15319348-1 2004 Both UDP-glucuronosyltransferase 2B4 (UGT2B4) and UGT2B7 are expressed mainly in the human liver and have several overlapping substrates; e.g., catechol estrogens, bile acids, codeine, and carvedilol. catechol 144-152 UDP glucuronosyltransferase family 2 member B4 Homo sapiens 38-44 15621715-4 2004 Furthermore, catecholamines such as 3,4-dihydroxyphenylalanine (DOPA), dopamine or norepinephrine were more effective than caffeic acid or pyrocatechol in promoting Cu(2+)-mediated inactivation of PON1, suggesting the importance of dihydroxybenzene group as well as amino group. catechol 139-151 paraoxonase 1 Homo sapiens 197-201 15319348-1 2004 Both UDP-glucuronosyltransferase 2B4 (UGT2B4) and UGT2B7 are expressed mainly in the human liver and have several overlapping substrates; e.g., catechol estrogens, bile acids, codeine, and carvedilol. catechol 144-152 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 50-56 15298951-3 2004 NAD(P)H:quinone oxoreductase (NQO1) stabilizes semiquinones, thus potentially preventing genetic damage from catechol estrogens, and the NQO1 C609T polymorphism seems functionally relevant. catechol 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 30-34 15294349-7 2004 We observed among especially susceptible to action of catechol are catalase (CAT) (100 ppm) and superoxide dismutase (SOD) (250 ppm). catechol 54-62 catalase Homo sapiens 77-80 15025557-0 2004 Deuterium isotope effect on the oxidation of monophenols and o-diphenols by tyrosinase. catechol 61-72 tyrosinase Homo sapiens 76-86 15028626-8 2004 To evaluate potential embryonic signals regulating Cx26 expression, uteri of pseudopregnant animals were incubated with different mediators in an organ-culture model, showing that catechol estrogen and mediators of the inflammatory cascade such as prostaglandin F(2alpha) and interleukin-1beta are able to induce Cx26 expression through the ER-independent pathway. catechol 180-188 gap junction protein, beta 2 Mus musculus 51-55 15319341-6 2004 9 +/- 3.1 microM; V(max) = 19.4 +/- 0.4 pmol of catechol/min/nmol of P450) may be involved in etoposide metabolism at therapeutic concentrations of free drug. catechol 48-56 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 69-73 15025557-1 2004 A solvent deuterium isotope effect on the catalytic affinity (km) and catalytic constant (kcat) of tyrosinase in its action on different monophenols and o-diphenols was observed. catechol 153-164 tyrosinase Homo sapiens 99-109 15157104-0 2004 Estrogen receptor-independent catechol estrogen binding activity: protein binding studies in wild-type, Estrogen receptor-alpha KO, and aromatase KO mice tissues. catechol 30-38 estrogen receptor 1 (alpha) Mus musculus 0-17 15025557-2 2004 The catalytic constant decreased in all substrates as the molar fraction of deuterated water in the medium increased, while the catalytic affinity only decreased for the o-diphenols with an R group in C-1 [-H, -CH3 and -CH(CH3)2]. catechol 170-181 heterogeneous nuclear ribonucleoprotein C Homo sapiens 201-204 15110290-6 2004 Following the optimisation of the paste composition, PPO-based carbon paste biosensors were prepared and presented excellent analytical properties toward catechol detection with a sensitivity of 4.7 A M(-1) cm(-2) and a response time lower than 20 s. The resulting biosensors were applied to the determination of polyphenolic compounds (e.g., epicatechin and ferulic acid). catechol 154-162 protoporphyrinogen oxidase Homo sapiens 53-56 15157104-9 2004 The extensive biochemical characterization of this binding protein indicates that this protein may be a receptor, and thus may mediate ERalpha/beta-independent effects of catechol estrogens and their metabolites. catechol 171-179 estrogen receptor 1 (alpha) Mus musculus 135-142 15100171-0 2004 Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase. catechol 92-100 catechol-O-methyltransferase Homo sapiens 146-174 15135645-5 2004 All the 4-hydroxylated catechols induced significantly more colony formations in V79 cells as compared to the parent phenols at 100nM, suggesting that the catechol estrogen metabolites are more mutagenic towards the hprt gene than estrogens. catechol 23-31 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 216-220 15089093-0 2004 Equine catechol estrogen 4-hydroxyequilenin is a more potent inhibitor of the variant form of catechol-O-methyltransferase. catechol 7-15 catechol O-methyltransferase Equus caballus 94-122 15100171-6 2004 The crude extracts from green tea and black tea also showed very strong activity in inhibiting human liver COMT-mediated O-methylation of catechol estrogens. catechol 138-146 catechol-O-methyltransferase Homo sapiens 107-111 15100171-7 2004 We also determined, for comparison, two common bioflavonoids (quercetin and fisetin) for their inhibitory effects on human liver COMT-mediated O-methylation of catechol estrogens. catechol 160-168 catechol-O-methyltransferase Homo sapiens 129-133 15100171-10 2004 In summary, the catechol-containing tea catechins and bioflavonoids are strong inhibitors of human liver COMT-mediated O-methylation of catechol estrogens. catechol 16-24 catechol-O-methyltransferase Homo sapiens 105-109 15100171-10 2004 In summary, the catechol-containing tea catechins and bioflavonoids are strong inhibitors of human liver COMT-mediated O-methylation of catechol estrogens. catechol 136-144 catechol-O-methyltransferase Homo sapiens 105-109 15051535-6 2004 Ratios of individual metabolite levels to total metabolite levels provided evidence of competitive inhibition of CYP 2E1 enzymes leading to increased production of phenol, catechol, and phenylmercapturic acid at the expense of hydroquinone, trihydroxybenzene, and muconic acid. catechol 172-180 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 113-120 14656940-9 2004 Our data suggest, that the CYP1B1 Ser allele may decrease endometrial cancer risk by altering the production of catechol estrogens. catechol 112-120 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 27-33 15089093-5 2004 To further understand the mechanism(s) of the association between the breast cancer risk and the COMT polymorphism, it was of interest to study the effect of the Val/Met polymorphism on COMT-catalyzed catechol estrogen methylation and 4-OHEN-mediated inhibition. catechol 201-209 catechol O-methyltransferase Equus caballus 97-101 15089093-5 2004 To further understand the mechanism(s) of the association between the breast cancer risk and the COMT polymorphism, it was of interest to study the effect of the Val/Met polymorphism on COMT-catalyzed catechol estrogen methylation and 4-OHEN-mediated inhibition. catechol 201-209 catechol O-methyltransferase Equus caballus 186-190 15050414-8 2004 In the present study, we have demonstrated that one of the catechol estrogen metabolites of E2, 4-OHE2, induces HIF-1alpha and VEGF-A expression at protein level in two human ovarian cancer cell lines, OVCAR-3 and A2780-CP70 cells, in dose- and time-dependent manners, whereas the other catechol estrogen metabolite of E2, 2-OHE2, does not alter HIF-1alpha and VEGF-A expression. catechol 59-67 hypoxia inducible factor 1 subunit alpha Homo sapiens 112-122 15050414-8 2004 In the present study, we have demonstrated that one of the catechol estrogen metabolites of E2, 4-OHE2, induces HIF-1alpha and VEGF-A expression at protein level in two human ovarian cancer cell lines, OVCAR-3 and A2780-CP70 cells, in dose- and time-dependent manners, whereas the other catechol estrogen metabolite of E2, 2-OHE2, does not alter HIF-1alpha and VEGF-A expression. catechol 59-67 vascular endothelial growth factor A Homo sapiens 127-133 15050414-8 2004 In the present study, we have demonstrated that one of the catechol estrogen metabolites of E2, 4-OHE2, induces HIF-1alpha and VEGF-A expression at protein level in two human ovarian cancer cell lines, OVCAR-3 and A2780-CP70 cells, in dose- and time-dependent manners, whereas the other catechol estrogen metabolite of E2, 2-OHE2, does not alter HIF-1alpha and VEGF-A expression. catechol 59-67 hypoxia inducible factor 1 subunit alpha Homo sapiens 346-356 15050414-8 2004 In the present study, we have demonstrated that one of the catechol estrogen metabolites of E2, 4-OHE2, induces HIF-1alpha and VEGF-A expression at protein level in two human ovarian cancer cell lines, OVCAR-3 and A2780-CP70 cells, in dose- and time-dependent manners, whereas the other catechol estrogen metabolite of E2, 2-OHE2, does not alter HIF-1alpha and VEGF-A expression. catechol 59-67 vascular endothelial growth factor A Homo sapiens 361-367 15050414-8 2004 In the present study, we have demonstrated that one of the catechol estrogen metabolites of E2, 4-OHE2, induces HIF-1alpha and VEGF-A expression at protein level in two human ovarian cancer cell lines, OVCAR-3 and A2780-CP70 cells, in dose- and time-dependent manners, whereas the other catechol estrogen metabolite of E2, 2-OHE2, does not alter HIF-1alpha and VEGF-A expression. catechol 287-295 hypoxia inducible factor 1 subunit alpha Homo sapiens 112-122 14979715-9 2004 Despite being largely structurally different from PGD(2), rutin is located at the same site of PGD(2), and its catechol and rhamnose moieties are involved in hydrogen bonds with PGFS. catechol 111-119 aldo-keto reductase family 1 member C3 Homo sapiens 178-182 15075793-8 2004 Also, a higher induction of CYP1B1 enzyme by xenobiotics could increase the formation of genotoxic catechol-oestrogens among exposed women carrying the Val CYP1B1 allele. catechol 99-107 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 28-34 14993710-7 2004 A description of the catechol binding contributes to the understanding of lipoxygenase inhibition and the participation of its co-oxidative activity in the utilization of natural flavonoids. catechol 21-29 linoleate 9S-lipoxygenase-4 Glycine max 74-86 15006807-1 2004 Catechol 2,3-dioxygenase (C23O; EC 1.3.11.2), exemplified by XylE and NahH, catalyzes the ring cleavage of catechol and some substituted catechols. catechol 107-115 catechol 2,3-dioxygenase Pseudomonas putida 0-24 15006807-1 2004 Catechol 2,3-dioxygenase (C23O; EC 1.3.11.2), exemplified by XylE and NahH, catalyzes the ring cleavage of catechol and some substituted catechols. catechol 107-115 catechol 2,3-dioxygenase Pseudomonas putida 26-30 15006807-1 2004 Catechol 2,3-dioxygenase (C23O; EC 1.3.11.2), exemplified by XylE and NahH, catalyzes the ring cleavage of catechol and some substituted catechols. catechol 107-115 catechol 2,3-dioxygenase Pseudomonas putida 70-74 15003008-2 2004 Tyrosinase is a copper-containing enzyme that catalyzes the hydroxylation of a monophenol (monophenolase activity) and the oxidation of an o-diphenol (diphenolase activity). catechol 139-149 tyrosinase Homo sapiens 0-10 15075793-8 2004 Also, a higher induction of CYP1B1 enzyme by xenobiotics could increase the formation of genotoxic catechol-oestrogens among exposed women carrying the Val CYP1B1 allele. catechol 99-107 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 156-162 14643889-1 2004 The kinetic behaviour of tyrosinase is very complex because the enzymatic oxidation of monophenol and o-diphenol to o-quinones occurs simultaneously with the coupled non-enzymatic reactions of the latter. catechol 102-112 tyrosinase Homo sapiens 25-35 14643889-5 2004 We previously confirmed the validity of the rate equations by the oxidation of numerous monophenols and o-diphenols catalysed by tyrosinase from different fruits and vegetables. catechol 104-115 tyrosinase Homo sapiens 129-139 15031547-1 2004 Catechol O-methyltransferase (COMT) inactivates catecholamines and catechol-containing drugs such as L-DOPA. catechol 48-56 catechol-O-methyltransferase Canis lupus familiaris 0-28 15031547-1 2004 Catechol O-methyltransferase (COMT) inactivates catecholamines and catechol-containing drugs such as L-DOPA. catechol 48-56 catechol-O-methyltransferase Canis lupus familiaris 30-34 14966473-1 2004 Catechol O-methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catecholestrogens and catechol drugs. catechol 81-89 catechol-O-methyltransferase Homo sapiens 0-28 14966473-1 2004 Catechol O-methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catecholestrogens and catechol drugs. catechol 81-89 catechol-O-methyltransferase Homo sapiens 30-34 14727916-2 2004 The planar catechin (P1H(2)), in which the catechol and chroman structure in (+)-catechin (1H(2)) are constrained to be planar, undergoes efficient hydrogen atom transfer toward galvinoxyol radical, showing an enhanced protective effect against the oxidative DNA damage induced by the Fenton reaction. catechol 43-51 minichromosome maintenance complex component 3 Homo sapiens 21-24 12969965-10 2004 The UGT1A1 6/6 genotype predicted lower catechol AUC. catechol 40-48 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 4-10 14999007-9 2004 The structure of the rat AADC-dopa complex modeled on the crystal structure of pig AADC showed that the flexible loop can fit in the concave surface at the entrance of the active site, its aliphatic and aromatic residues forming hydrophobic interactions with the substrate catechol ring. catechol 273-281 dopa decarboxylase Rattus norvegicus 25-29 15089093-11 2004 These data suggest that 4-OHEN-mediated inhibition of the variant form of COMT in vivo might affect the detoxification efficiency of endogenous and/or exogenous catechol estrogens and play a role in the association between breast cancer risk and COMT polymorphism. catechol 161-169 catechol O-methyltransferase Equus caballus 74-78 15089093-11 2004 These data suggest that 4-OHEN-mediated inhibition of the variant form of COMT in vivo might affect the detoxification efficiency of endogenous and/or exogenous catechol estrogens and play a role in the association between breast cancer risk and COMT polymorphism. catechol 161-169 catechol O-methyltransferase Equus caballus 246-250 14999007-9 2004 The structure of the rat AADC-dopa complex modeled on the crystal structure of pig AADC showed that the flexible loop can fit in the concave surface at the entrance of the active site, its aliphatic and aromatic residues forming hydrophobic interactions with the substrate catechol ring. catechol 273-281 dopa decarboxylase Sus scrofa 83-87 14679015-9 2003 The concentration gap between catechol estrogens and GSH-estrogen conjugates may result from nonenzymatic reaction of the labile quinones with other nucleophiles besides GSH or may reflect the lower efficiency of GSTP1 compared with CYP1B1. catechol 30-38 glutathione S-transferase pi 1 Homo sapiens 213-218 15288375-9 2004 Polymorphism such as cytochrome P450c17 (A2/A2), cytochrome P450c1A (vt/vt) will result in increased formation of catechol estrogen, while people with catechol-O-methyltransferase (COMT) polymorphism COMT (L/L) will have decreased metabolism of catechol estrogen and decreased level of methoxyestradiol. catechol 114-122 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 32-39 15288375-9 2004 Polymorphism such as cytochrome P450c17 (A2/A2), cytochrome P450c1A (vt/vt) will result in increased formation of catechol estrogen, while people with catechol-O-methyltransferase (COMT) polymorphism COMT (L/L) will have decreased metabolism of catechol estrogen and decreased level of methoxyestradiol. catechol 114-122 catechol-O-methyltransferase Homo sapiens 151-179 15288375-9 2004 Polymorphism such as cytochrome P450c17 (A2/A2), cytochrome P450c1A (vt/vt) will result in increased formation of catechol estrogen, while people with catechol-O-methyltransferase (COMT) polymorphism COMT (L/L) will have decreased metabolism of catechol estrogen and decreased level of methoxyestradiol. catechol 114-122 catechol-O-methyltransferase Homo sapiens 181-185 15288375-9 2004 Polymorphism such as cytochrome P450c17 (A2/A2), cytochrome P450c1A (vt/vt) will result in increased formation of catechol estrogen, while people with catechol-O-methyltransferase (COMT) polymorphism COMT (L/L) will have decreased metabolism of catechol estrogen and decreased level of methoxyestradiol. catechol 114-122 catechol-O-methyltransferase Homo sapiens 200-204 15288375-9 2004 Polymorphism such as cytochrome P450c17 (A2/A2), cytochrome P450c1A (vt/vt) will result in increased formation of catechol estrogen, while people with catechol-O-methyltransferase (COMT) polymorphism COMT (L/L) will have decreased metabolism of catechol estrogen and decreased level of methoxyestradiol. catechol 151-159 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 32-39 15288375-9 2004 Polymorphism such as cytochrome P450c17 (A2/A2), cytochrome P450c1A (vt/vt) will result in increased formation of catechol estrogen, while people with catechol-O-methyltransferase (COMT) polymorphism COMT (L/L) will have decreased metabolism of catechol estrogen and decreased level of methoxyestradiol. catechol 151-159 catechol-O-methyltransferase Homo sapiens 181-185 15288375-9 2004 Polymorphism such as cytochrome P450c17 (A2/A2), cytochrome P450c1A (vt/vt) will result in increased formation of catechol estrogen, while people with catechol-O-methyltransferase (COMT) polymorphism COMT (L/L) will have decreased metabolism of catechol estrogen and decreased level of methoxyestradiol. catechol 151-159 catechol-O-methyltransferase Homo sapiens 200-204 18969255-1 2003 Pyrocatechol is immobilized on cellulose via NHCH(2)CH(2)NHSO(2)C(6)H(4)NN linker and the resulting macromolecular chelator characterized by IR, TGA, CPMAS (13)C NMR and elemental analyses. catechol 0-12 T-box transcription factor 1 Homo sapiens 145-148 14679015-1 2003 The Phase I enzyme cytochrome p450 1B1 (CYP1B1) has been postulated to play a key role in estrogen-induced mammary carcinogenesis by catalyzing the oxidative metabolism of 17beta-estradiol (E(2)) to catechol estrogens (2-OHE(2) and 4-OHE(2)) and highly reactive estrogen quinones (E(2)-2,3-Q and E(2)-3,4-Q). catechol 199-207 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 40-46 14679015-9 2003 The concentration gap between catechol estrogens and GSH-estrogen conjugates may result from nonenzymatic reaction of the labile quinones with other nucleophiles besides GSH or may reflect the lower efficiency of GSTP1 compared with CYP1B1. catechol 30-38 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 233-239 14520706-9 2003 Alternatively, the Val CYP1B1 or His SULT1A1 allele with modified ability to metabolize estrogens could increase the level of genotoxic catechol estrogen (i.e., 4-hydroxy-estradiol) among smokers. catechol 136-144 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 23-29 15124929-6 2003 The models suggest that an interaction between the inhibitor"s catechol oxygens and the Mg2+ ion in the COMT active site is important. catechol 63-71 catechol-O-methyltransferase Homo sapiens 104-108 15124929-8 2003 Docking suggests that a large R1 substituent of the catechol ring can form hydrophobic contacts with side chains of Val173, Leu198, Met201 and Val203 on the COMT surface. catechol 52-60 catechol-O-methyltransferase Homo sapiens 157-161 14520706-9 2003 Alternatively, the Val CYP1B1 or His SULT1A1 allele with modified ability to metabolize estrogens could increase the level of genotoxic catechol estrogen (i.e., 4-hydroxy-estradiol) among smokers. catechol 136-144 sulfotransferase family 1A member 1 Homo sapiens 37-44 12869569-0 2003 Development of new insulin-like growth factor-1 receptor kinase inhibitors using catechol mimics. catechol 81-89 insulin like growth factor 1 receptor Homo sapiens 19-56 18969209-5 2003 In the batch mode the biosensors responded linearly to catechol up to 30 muM with limits of detection from 0.14 muM. catechol 55-63 latexin Homo sapiens 73-76 18969209-5 2003 In the batch mode the biosensors responded linearly to catechol up to 30 muM with limits of detection from 0.14 muM. catechol 55-63 latexin Homo sapiens 112-115 14612555-5 2003 Because catechol-containing tea polyphenols are very rapidly O-methylated by human catechol-O-methyltransferase (COMT), we are interested in determining whether the association between tea intake and breast cancer differed in women according to COMT genotype. catechol 8-16 catechol-O-methyltransferase Homo sapiens 83-111 14612555-5 2003 Because catechol-containing tea polyphenols are very rapidly O-methylated by human catechol-O-methyltransferase (COMT), we are interested in determining whether the association between tea intake and breast cancer differed in women according to COMT genotype. catechol 8-16 catechol-O-methyltransferase Homo sapiens 113-117 14562027-1 2003 CYP1B1 has been evaluated as a candidate gene for various cancers because of its function in activating environmental procarcinogens and catalysing the conversion of oestrogens to genotoxic catechol oestrogens. catechol 190-198 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 12869569-11 2003 The ability to replace catechol groups with a moiety that is more stable in cells may aid in developing non-catechol-containing substrate-competitive inhibitors targeted toward IGF-1R and possibly against other protein-tyrosine kinases. catechol 23-31 insulin like growth factor 1 receptor Homo sapiens 177-183 12869569-11 2003 The ability to replace catechol groups with a moiety that is more stable in cells may aid in developing non-catechol-containing substrate-competitive inhibitors targeted toward IGF-1R and possibly against other protein-tyrosine kinases. catechol 108-116 insulin like growth factor 1 receptor Homo sapiens 177-183 14710821-6 2003 Following the optimization of the paste composition, PPO-based carbon paste biosensors were prepared and presented excellent analytical properties toward catechol detection with a sensitivity of 4.7 A M(-1) cm(-2) and a response time lower than 20 s. The resulting biosensors were finally applied to the determination of epicatechin and ferulic acid as flavonol and polyphenol model, respectively. catechol 154-162 protoporphyrinogen oxidase Homo sapiens 53-56 14522084-0 2003 Nrf2, not the estrogen receptor, mediates catechol estrogen-induced activation of the antioxidant responsive element. catechol 42-50 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 14522084-5 2003 Since 4-hydroxyestradiol-induced ARE activation was not inhibited by either 17beta-estradiol or tamoxifen, and overexpression of ER-alpha decreased 4-hydroxyestradiol-induced ARE activation, ARE activation by catechol estrogen was independent of ER. catechol 209-217 estrogen receptor 1 Homo sapiens 129-137 14522084-5 2003 Since 4-hydroxyestradiol-induced ARE activation was not inhibited by either 17beta-estradiol or tamoxifen, and overexpression of ER-alpha decreased 4-hydroxyestradiol-induced ARE activation, ARE activation by catechol estrogen was independent of ER. catechol 209-217 estrogen receptor 1 Homo sapiens 129-131 12922176-0 2003 Solvent deuterium isotope effect on the oxidation of o-diphenols by tyrosinase. catechol 53-64 tyrosinase Homo sapiens 68-78 12865317-5 2003 CYP1B1 mainly catalyzed the formation of catechol estrogens, with 4-hydroxyestrogens predominant. catechol 41-49 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 12899964-1 2003 The development and characterisation of a new biosensor for hydroperoxides is described, which is obtained by combining an oxygen gas diffusion amperometric electrode and two immobilized enzymes (peroxidase and tyrosinase) working in parallel and competing for the same substrate (catechol). catechol 281-289 tyrosinase Homo sapiens 211-221 12707935-1 2003 COMT is a ubiquitous enzyme crucial to catechol metabolism. catechol 39-47 catechol-O-methyltransferase Homo sapiens 0-4 12859624-0 2003 Mechanistic studies of catechol generation from secondary quinone amines relevant to indole formation and tyrosinase activation. catechol 23-31 tyrosinase Homo sapiens 106-116 12859624-8 2003 To investigate the potential biological applications of this chemistry the system was also examined by tyrosinase-catalysed oxidation of the catecholamine substrates in which there is re-oxidation of the catechol formed by the redox exchange reaction and enables measurement of oxygen utilization stoichiometry. catechol 141-149 tyrosinase Homo sapiens 103-113 12884403-1 2003 Catechol-O-methyltransferase (COMT) enzyme is a widely distributed enzyme that catalyses O-methylation of catecholamines and other compounds having a catechol structure. catechol 106-114 catechol-O-methyltransferase Mus musculus 0-28 12884403-1 2003 Catechol-O-methyltransferase (COMT) enzyme is a widely distributed enzyme that catalyses O-methylation of catecholamines and other compounds having a catechol structure. catechol 106-114 catechol-O-methyltransferase Mus musculus 30-34 12810635-1 2003 Catechol-O-methyltransferase (COMT) plays an important role in estrogen-induced cancers because COMT inactivates catechol estrogens that have cancer-promoting activities. catechol 113-121 catechol-O-methyltransferase Homo sapiens 0-28 12810635-1 2003 Catechol-O-methyltransferase (COMT) plays an important role in estrogen-induced cancers because COMT inactivates catechol estrogens that have cancer-promoting activities. catechol 113-121 catechol-O-methyltransferase Homo sapiens 30-34 12810635-1 2003 Catechol-O-methyltransferase (COMT) plays an important role in estrogen-induced cancers because COMT inactivates catechol estrogens that have cancer-promoting activities. catechol 113-121 catechol-O-methyltransferase Homo sapiens 96-100 12810639-1 2003 Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) catalyze the oxidative metabolism of 17 beta-estradiol (E2) to catechol estrogens (2-OHE2 and 4-OHE2) and estrogen quinones, which may lead to DNA damage. catechol 109-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 12810639-1 2003 Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) catalyze the oxidative metabolism of 17 beta-estradiol (E2) to catechol estrogens (2-OHE2 and 4-OHE2) and estrogen quinones, which may lead to DNA damage. catechol 109-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 12810639-1 2003 Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) catalyze the oxidative metabolism of 17 beta-estradiol (E2) to catechol estrogens (2-OHE2 and 4-OHE2) and estrogen quinones, which may lead to DNA damage. catechol 109-117 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 38-44 12810639-1 2003 Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) catalyze the oxidative metabolism of 17 beta-estradiol (E2) to catechol estrogens (2-OHE2 and 4-OHE2) and estrogen quinones, which may lead to DNA damage. catechol 109-117 dihydrolipoamide branched chain transacylase E2 Homo sapiens 102-104 12810639-2 2003 Catechol-O-methyltransferase catalyzes the methylation of catechol estrogens to methoxyestrogens (2-MeOE2, 2-OH-3-MeOE2, and 4-MeOE2), which simultaneously lowers the potential for DNA damage and increases the concentration of 2-MeOE2, an antiproliferative metabolite. catechol 58-66 catechol-O-methyltransferase Homo sapiens 0-28 12810639-4 2003 Using purified recombinant enzymes, we demonstrated that CYP1A1 and CYP1B1 O-demethylated the methoxyestrogens to catechol estrogens according to Michaelis-Menten kinetics. catechol 114-122 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 57-63 12810639-4 2003 Using purified recombinant enzymes, we demonstrated that CYP1A1 and CYP1B1 O-demethylated the methoxyestrogens to catechol estrogens according to Michaelis-Menten kinetics. catechol 114-122 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 68-74 12755597-0 2003 Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase. catechol 0-8 catechol-O-methyltransferase Homo sapiens 72-100 12755639-4 2003 Using a combination of enzyme oximetry, pulse radiolysis, and chemical oxidation, the study of structurally modified dopaquinones provides firm evidence of nonenzymatic catechol formation during tyrosinase oxidation of phenols and reveals significant differences in their modes of reaction. catechol 169-177 tyrosinase Homo sapiens 195-205 12755597-6 2003 In addition, 4-OHEN was found to be an irreversible inhibitor of COMT-catalyzed methylation of the endogenous catechol estrogen 4-hydroxyestradiol with a K(i) of 26.0 microM and a k(2) of 1.62 x 10(-)(2) s(-)(1). catechol 110-118 catechol-O-methyltransferase Homo sapiens 65-69 12755597-9 2003 These data suggest that inhibition of COMT methylation by 4-OHEN might reduce endogenous catechol estrogen clearance in vivo and further enhance toxicity. catechol 89-97 catechol-O-methyltransferase Homo sapiens 38-42 12739038-11 2003 In conclusion, COMT polymorphism is of potential pharmacological importance regarding individual differences in the metabolism of catechol drugs and may also be involved in the pathogenesis and treatment of FS through adrenergic mechanisms as well as genetic predisposition to FS. catechol 130-138 catechol-O-methyltransferase Homo sapiens 15-19 12623074-5 2003 Recombinant human UGT1A6, 1A9, and 2B7, stably expressed in mammalian cells, all effectively catalyzed catechol glucuronidation. catechol 103-111 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 18-24 12584150-1 2003 Catechol-O-methyltransferase (COMT, EC 2.1.1.6) plays a central role in the metabolic inactivation of neurotransmitters and neuroactive xenobiotics possessing a catechol motif. catechol 161-169 catechol-O-methyltransferase Homo sapiens 0-28 12584150-1 2003 Catechol-O-methyltransferase (COMT, EC 2.1.1.6) plays a central role in the metabolic inactivation of neurotransmitters and neuroactive xenobiotics possessing a catechol motif. catechol 161-169 catechol-O-methyltransferase Homo sapiens 30-34 12584150-7 2003 Both compounds undergo in vivo O-methylation by COMT at either meta or para catechol hydroxyl groups. catechol 76-84 catechol-O-methyltransferase Homo sapiens 48-52 12929389-2 2003 A series of new potent bisubstrate inhibitors for COMT, resulting from X-ray structure-based design and featuring adenosine and catechol moieties have been synthesised. catechol 128-136 catechol-O-methyltransferase Homo sapiens 50-54 12604190-10 2003 Thus, catechol transiently induced increased levels of ALDH3A1 in the five ER(+) human breast (adeno)carcinoma cell lines, the four ER(-) human breast (adeno)carcinoma cell lines, and the ER(-), immortal but not tumorigenic, human breast epithelial cell line. catechol 6-14 aldehyde dehydrogenase 3 family member A1 Homo sapiens 55-62 12604190-10 2003 Thus, catechol transiently induced increased levels of ALDH3A1 in the five ER(+) human breast (adeno)carcinoma cell lines, the four ER(-) human breast (adeno)carcinoma cell lines, and the ER(-), immortal but not tumorigenic, human breast epithelial cell line. catechol 6-14 estrogen receptor 1 Homo sapiens 75-77 12604190-10 2003 Thus, catechol transiently induced increased levels of ALDH3A1 in the five ER(+) human breast (adeno)carcinoma cell lines, the four ER(-) human breast (adeno)carcinoma cell lines, and the ER(-), immortal but not tumorigenic, human breast epithelial cell line. catechol 6-14 estrogen receptor 1 Homo sapiens 132-134 12604190-10 2003 Thus, catechol transiently induced increased levels of ALDH3A1 in the five ER(+) human breast (adeno)carcinoma cell lines, the four ER(-) human breast (adeno)carcinoma cell lines, and the ER(-), immortal but not tumorigenic, human breast epithelial cell line. catechol 6-14 estrogen receptor 1 Homo sapiens 132-134 12609045-8 2003 Treatment of plants with catechol compromised Psp resistance suggesting that the effect of NahG on resistance results from catechol production. catechol 25-33 3-phosphoserine phosphatase Arabidopsis thaliana 46-49 12609045-8 2003 Treatment of plants with catechol compromised Psp resistance suggesting that the effect of NahG on resistance results from catechol production. catechol 123-131 3-phosphoserine phosphatase Arabidopsis thaliana 46-49 12609045-9 2003 Application of catalase to NahG or catechol-treated wild-type plants partially restored resistance to Psp, suggesting that the deleterious effect of catechol results from inappropriate production of hydrogen peroxide. catechol 35-43 3-phosphoserine phosphatase Arabidopsis thaliana 102-105 12609045-9 2003 Application of catalase to NahG or catechol-treated wild-type plants partially restored resistance to Psp, suggesting that the deleterious effect of catechol results from inappropriate production of hydrogen peroxide. catechol 149-157 3-phosphoserine phosphatase Arabidopsis thaliana 102-105 12009413-0 2002 Mechanistic implications of variable stoichiometries of oxygen consumption during tyrosinase catalyzed oxidation of monophenols and o-diphenols. catechol 132-143 tyrosinase Homo sapiens 82-92 12492331-6 2002 The third case is that of a catechol derivative (chosen as a model compound for polyphenolic antioxidants), where recycling of alpha-TOH is feasible even though the BDE value is significantly higher than that of vitamin E. catechol 28-36 homeobox D13 Homo sapiens 165-168 12553730-6 2002 The presence of the corresponding o-diphenol as intermediate was demonstrated with ascorbic acid by chemical oxidation using NaIO4 and by HPLC analysis, indicating that acetaminophen is oxidized by the monophenolase activity of tyrosinase to its corresponding o-quinone. catechol 34-44 tyrosinase Homo sapiens 228-238 12167570-8 2002 Thus, CYP2B6 demethylated methoxychlor to mono-OH-M and ortho-hydroxylated the mono-OH-M forming catechol-M; however, 2B6 did not appreciably demethylate mono-OH-M or ortho-hydroxylate bis-OH-M, suggesting a narrow substrate specificity. catechol 97-105 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 6-12 12167570-9 2002 CYP2C19-catalyzed demethylation of methoxychlor, mono-OH-M and catechol-M, demonstrating relatively good substrate affinity (K(m) = 0.23 - 0.41 microM). catechol 63-71 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 0-7 12167570-11 2002 Thus, a phenolic group seems essential for efficient ortho-hydroxylation, forming catechol-M and tris-OH-M. Inhibition studies with HLM and P450s indicate that CYP2C9 and likely 2C19 are catalysts of methoxychlor-mono-demethylation. catechol 82-90 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 160-166 12127525-1 2002 A detailed study directed towards metabolic stability optimization of the alkoxy substituents on the catechol moiety of CDP-840 is reported. catechol 101-109 cut like homeobox 1 Homo sapiens 120-123 12450669-1 2002 Catechol O-methyltransferase (COMT) transfers a methyl group from S-adenosyl-L-methionine to the catechol substrate in the presence of magnesium. catechol 97-105 catechol-O-methyltransferase Homo sapiens 0-28 12450669-1 2002 Catechol O-methyltransferase (COMT) transfers a methyl group from S-adenosyl-L-methionine to the catechol substrate in the presence of magnesium. catechol 97-105 catechol-O-methyltransferase Homo sapiens 30-34 12392962-9 2002 The analytical range for GSH is dependent on the concentration of the tyrosinase substrate (catechol). catechol 92-100 tyrosinase Homo sapiens 70-80 12433804-8 2002 Anthraflavic acid and catechol estrogen glucuronidation, catalyzed by UGT1A1, was also not inhibited by etonitazenyl or buprenorphine. catechol 22-30 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 70-76 12371153-2 2002 In this paper, a unifying hypothesis is proposed which suggests that hyperhomocysteinemia may exert its pathogenic effects largely through metabolic accumulation of S-adenosyl-L-homocysteine, a strong noncompetitive inhibitor of the catechol-O-methyltransferase (COMT)-mediated methylation metabolism of various catechol substrates (such as catecholamines and catechol estrogens). catechol 233-241 catechol-O-methyltransferase Homo sapiens 263-267 12371153-2 2002 In this paper, a unifying hypothesis is proposed which suggests that hyperhomocysteinemia may exert its pathogenic effects largely through metabolic accumulation of S-adenosyl-L-homocysteine, a strong noncompetitive inhibitor of the catechol-O-methyltransferase (COMT)-mediated methylation metabolism of various catechol substrates (such as catecholamines and catechol estrogens). catechol 312-320 catechol-O-methyltransferase Homo sapiens 233-261 12360102-1 2002 The major detoxification pathway of the carcinogenic catechol estrogens is methylation by catechol- -methyltransferase (COMT). catechol 53-61 catechol-O-methyltransferase Homo sapiens 90-118 12360102-1 2002 The major detoxification pathway of the carcinogenic catechol estrogens is methylation by catechol- -methyltransferase (COMT). catechol 53-61 catechol-O-methyltransferase Homo sapiens 120-124 12360102-2 2002 It has been hypothesized that the enzyme encoded by the low-activity allele (COMT(L) ) has a lower catalytic activity for catechol estrogen methylation than that encoded by the high activity allele (COMT(H) ). catechol 122-130 catechol-O-methyltransferase Homo sapiens 77-81 12360102-2 2002 It has been hypothesized that the enzyme encoded by the low-activity allele (COMT(L) ) has a lower catalytic activity for catechol estrogen methylation than that encoded by the high activity allele (COMT(H) ). catechol 122-130 catechol-O-methyltransferase Homo sapiens 199-203 12204291-2 2002 Differential normal pulse voltammetry with carbon fiber electrodes identified distinct oxidation currents at +120 mV (peak 1: catechol signals) and +280 mV (peak 2: 5-hydroxyindole signals). catechol 126-134 pseudopodium-enriched atypical kinase 1 Rattus norvegicus 118-124 12119004-2 2002 We have previously shown that human GST P1-1, which is the most widely distributed extrahepatic isozyme, could be inactivated by the catechol estrogen metabolite 4-hydroxyequilenin (4-OHEN) in vitro [Chang, M., Shin, Y. G., van Breemen, R. B., Blond, S. Y., and Bolton, J. L. (2001) Biochemistry 40, 4811-4820]. catechol 133-141 glutathione S-transferase pi 1 Homo sapiens 36-44 12119004-3 2002 In the present study, we found that 4-OHEN and another catechol estrogen, 4,17beta-hydroxyequilenin (4,17beta-OHEN), significantly decreased GSH levels and the activity of GST within minutes in both estrogen receptor (ER) negative (MDA-MB-231) and ER positive (S30) human breast cancer cells. catechol 55-63 estrogen receptor 1 Homo sapiens 199-216 12119004-3 2002 In the present study, we found that 4-OHEN and another catechol estrogen, 4,17beta-hydroxyequilenin (4,17beta-OHEN), significantly decreased GSH levels and the activity of GST within minutes in both estrogen receptor (ER) negative (MDA-MB-231) and ER positive (S30) human breast cancer cells. catechol 55-63 estrogen receptor 1 Homo sapiens 218-220 12119004-3 2002 In the present study, we found that 4-OHEN and another catechol estrogen, 4,17beta-hydroxyequilenin (4,17beta-OHEN), significantly decreased GSH levels and the activity of GST within minutes in both estrogen receptor (ER) negative (MDA-MB-231) and ER positive (S30) human breast cancer cells. catechol 55-63 estrogen receptor 1 Homo sapiens 248-250 12119004-9 2002 These data suggest that GST P1-1 may be a preferred protein target for equine catechol estrogens in vivo. catechol 78-86 glutathione S-transferase pi 1 Homo sapiens 24-30 12009413-1 2002 The stoichiometry of oxygen consumption during tyrosinase-catalyzed oxidation of an o-diphenol (4-tert-butylcatechol, TBC) and a monophenol (4-tert-butylphenol, TBP) has been determined. catechol 84-94 tyrosinase Homo sapiens 47-57 12009413-1 2002 The stoichiometry of oxygen consumption during tyrosinase-catalyzed oxidation of an o-diphenol (4-tert-butylcatechol, TBC) and a monophenol (4-tert-butylphenol, TBP) has been determined. catechol 84-94 TBC1 domain family member 1 Homo sapiens 118-121 12009413-8 2002 267 (1992) 3801-3810], in which, during hydroxylation of monophenols, tyrosinase first transformed monophenol to o-diphenol and then either catalyzed a further oxidation to form o-quinone or released it into the reaction medium. catechol 113-123 tyrosinase Homo sapiens 70-80 12018987-10 2002 Taking into account the fact that the anti-oxidant action as well as the pro-oxidant toxicity of these catechol-type flavonoids is especially related to their 3",4"-dihydroxyl moiety, it is of interest to note that the human intestine UGT"s appear to be especially effective in conjugating this 3",4" catechol unit. catechol 103-111 beta-1,3-glucuronyltransferase 2 Homo sapiens 235-238 11559542-0 2001 Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms. catechol 59-67 catechol-O-methyltransferase Homo sapiens 0-28 11849292-1 2002 Catechol-O-methyltransferase (COMT) catalyses the O-methylation of compounds having a catechol structure and its main function involves the elimination of biologically active or toxic catechols and their metabolites. catechol 86-94 catechol-O-methyltransferase Mus musculus 0-28 11849292-1 2002 Catechol-O-methyltransferase (COMT) catalyses the O-methylation of compounds having a catechol structure and its main function involves the elimination of biologically active or toxic catechols and their metabolites. catechol 86-94 catechol-O-methyltransferase Mus musculus 30-34 11701230-3 2001 To exert its toxic effects, benzene must be metabolized by cytochrome P450 to phenol and subsequently to catechol and hydroquinone. catechol 105-113 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 59-74 18968452-5 2001 However, the dynamic range was considerably smaller (0.025-14 muM) indicating that the enzyme molecules were easily accessible to the substrate catechol. catechol 144-152 latexin Homo sapiens 62-65 11714513-0 2001 Mediated electrochemical detection of catechol by tyrosinase-based poly(dicarbazole) electrodes. catechol 38-46 tyrosinase Homo sapiens 50-60 11780762-2 2001 The metabolic O-methylation of several catechol-containing tea polyphenols by rat liver cytosolic catechol-O-methyltransferase (COMT) has been studied. catechol 39-47 catechol-O-methyltransferase Rattus norvegicus 98-126 11780762-2 2001 The metabolic O-methylation of several catechol-containing tea polyphenols by rat liver cytosolic catechol-O-methyltransferase (COMT) has been studied. catechol 39-47 catechol-O-methyltransferase Rattus norvegicus 128-132 11780762-12 2001 In summary, the results showed that several catechol-containing tea polyphenols were rapidly O-methylated by rat liver cytosolic COMT. catechol 44-52 catechol-O-methyltransferase Rattus norvegicus 129-133 11780762-13 2001 These observations raise the possibility that some of the biological effects of tea polyphenols may be exerted by their O-methylated products or may result from their potential inhibition of the COMT-catalysed O-methylation of endogenous catecholamines and catechol oestrogens. catechol 238-246 catechol-O-methyltransferase Rattus norvegicus 195-199 11597779-8 2001 In conclusion, the COMT polymorphism may be of potential pharmacological importance regarding the individual differences in the metabolism of catechol drugs in migraineurs. catechol 142-150 catechol-O-methyltransferase Homo sapiens 19-23 11606384-3 2001 O-Methylation catalyzed by catechol-O-methyltransferase (COMT) is a Phase II metabolic inactivation pathway for catechol estrogens. catechol 27-35 catechol-O-methyltransferase Homo sapiens 57-61 11606384-4 2001 We and others have found that a polymorphism in the COMT gene, which codes for a low activity variant of the COMT enzyme, is associated with an increased risk of developing breast cancer; therefore, the goal of the current study was to investigate the role of decreased COMT activity on estrogen catechol levels and on oxidative DNA damage, as measured by 8-hydroxy-2"-deoxyguanosine (8-oxo-dG) levels. catechol 296-304 catechol-O-methyltransferase Homo sapiens 52-56 11577006-1 2001 Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens (CEs), using S-adenosylmethionine (SAM) as a methyl donor. catechol 67-75 catechol-O-methyltransferase Homo sapiens 0-28 11577006-1 2001 Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catechol estrogens (CEs), using S-adenosylmethionine (SAM) as a methyl donor. catechol 67-75 catechol-O-methyltransferase Homo sapiens 30-34 11559542-0 2001 Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms. catechol 59-67 catechol-O-methyltransferase Homo sapiens 30-34 11559542-0 2001 Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms. catechol 59-67 catechol-O-methyltransferase Homo sapiens 115-119 11559542-2 2001 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catechol estrogens to methoxy estrogens, which simultaneously lowers the potential for DNA damage and increases the concentration of 2-methoxyestradiol (2-MeOE2), an antiproliferative metabolite. catechol 65-73 catechol-O-methyltransferase Homo sapiens 0-28 11559542-2 2001 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catechol estrogens to methoxy estrogens, which simultaneously lowers the potential for DNA damage and increases the concentration of 2-methoxyestradiol (2-MeOE2), an antiproliferative metabolite. catechol 65-73 catechol-O-methyltransferase Homo sapiens 30-34 11559542-11 2001 Thus, inherited alterations in COMT catalytic activity are associated with significant differences in catechol estrogen and methoxy estrogen levels and, thereby, may contribute to interindividual differences in breast cancer risk associated with estrogen-mediated carcinogenicity. catechol 102-110 catechol-O-methyltransferase Homo sapiens 31-35 11556837-3 2001 O-methylation, catalysed by Catechol-O-Methyltransferase (COMT), is one pathway by which the potentially carcinogenic catechol oestrogens can be inactivated. catechol 118-126 catechol-O-methyltransferase Homo sapiens 28-56 11556837-3 2001 O-methylation, catalysed by Catechol-O-Methyltransferase (COMT), is one pathway by which the potentially carcinogenic catechol oestrogens can be inactivated. catechol 118-126 catechol-O-methyltransferase Homo sapiens 58-62 11532882-0 2001 Catechol estrogen metabolites and conjugates in mammary tumors and hyperplastic tissue from estrogen receptor-alpha knock-out (ERKO)/Wnt-1 mice: implications for initiation of mammary tumors. catechol 0-8 estrogen receptor 1 (alpha) Mus musculus 92-115 11708058-0 2001 Electrochemical behavior of catechol and 3,4-dihydroxytoluene in acetonitrile at a platinum-disk electrode modified with a tyrosinase containing polyacrylamide film. catechol 28-36 tyrosinase Homo sapiens 123-133 11708058-1 2001 A modified platinum-disk electrode coated with a non-plasticized polyacrylamide (PAA) membrane was used to study electrochemically an enzymatic reaction between tyrosinase in the PAA membrane and catechol and 3,4-dihydroxytoluene in acetonitrile (AN). catechol 196-204 tyrosinase Homo sapiens 161-171 11532882-0 2001 Catechol estrogen metabolites and conjugates in mammary tumors and hyperplastic tissue from estrogen receptor-alpha knock-out (ERKO)/Wnt-1 mice: implications for initiation of mammary tumors. catechol 0-8 wingless-type MMTV integration site family, member 1 Mus musculus 133-138 18968327-0 2001 Viscosity and binder composition effects on tyrosinase-based carbon paste electrode for detection of phenol and catechol. catechol 112-120 tyrosinase Homo sapiens 44-54 11513969-0 2001 Tyrosinase action on monophenols: evidence for direct enzymatic release of o-diphenol. catechol 75-85 tyrosinase Homo sapiens 0-10 11513969-1 2001 Using gas chromatography-mass spectrometry, the direct enzymatic release of o-diphenol (4-tert-butylcatechol) during the action of tyrosinase on a monophenol (4-tert-butylphenol) has been demonstrated for the first time in the literature. catechol 76-86 tyrosinase Homo sapiens 131-141 11504641-2 2001 Replacement of the 3,4-dihydroxyl group of the catechol moiety with 4-hydroxyl-3-methyl sulfonamide on the left-hand side of the compounds resulted in a number of potent full agonists at the beta(3) receptor. catechol 47-55 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 191-198 11606384-4 2001 We and others have found that a polymorphism in the COMT gene, which codes for a low activity variant of the COMT enzyme, is associated with an increased risk of developing breast cancer; therefore, the goal of the current study was to investigate the role of decreased COMT activity on estrogen catechol levels and on oxidative DNA damage, as measured by 8-hydroxy-2"-deoxyguanosine (8-oxo-dG) levels. catechol 296-304 catechol-O-methyltransferase Homo sapiens 109-113 11606384-4 2001 We and others have found that a polymorphism in the COMT gene, which codes for a low activity variant of the COMT enzyme, is associated with an increased risk of developing breast cancer; therefore, the goal of the current study was to investigate the role of decreased COMT activity on estrogen catechol levels and on oxidative DNA damage, as measured by 8-hydroxy-2"-deoxyguanosine (8-oxo-dG) levels. catechol 296-304 catechol-O-methyltransferase Homo sapiens 109-113 18968327-1 2001 The systematic study of the effect of binder viscosity on the sensitivity of a tyrosinase-based carbon paste electrode (CPE) biosensor for phenol and catechol is reported. catechol 150-158 tyrosinase Homo sapiens 79-89 18968331-3 2001 Phenol was oxidized by tyrosinase and horse-radish peroxidase via catechol to o-quinone in the presence of oxygen and hydrogen peroxide. catechol 66-74 tyrosinase Equus caballus 23-33 11749194-2 2001 The paper was impregnated with a tripeptide, DOPA-Gly-Gly, or a protein (BSA) plus catechol and treated with tyrosinase to oxidize the catechol. catechol 135-143 tyrosinase Homo sapiens 109-119 11459198-4 2001 METHODS: Using a crossover study design, we compared the pharmacokinetics of etoposide and its CYP3A4-formed catechol metabolite when given as a 300 mg/m2 i.v. catechol 109-117 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 95-101 11453730-4 2001 Using UV spectroscopy, it was shown that the catechol B-ring of catechin was oxidized by tyrosinase to form an o-quinone which could be reduced back to catechin with potassium borohydride or reacted with GSH to form glutathione conjugates. catechol 45-53 tyrosinase Rattus norvegicus 89-99 11473400-2 2001 The genotype of cytochrome P450 3A4 (CYP3A4), which converts etoposide to its catechol metabolite, influences the risk. catechol 78-86 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 16-35 11473400-2 2001 The genotype of cytochrome P450 3A4 (CYP3A4), which converts etoposide to its catechol metabolite, influences the risk. catechol 78-86 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 37-43 11440283-2 2001 Much of this degradation is produced by catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of catecholamines and catechol compounds. catechol 40-48 catechol-O-methyltransferase Homo sapiens 70-74 11410004-11 2001 Methylated forms of the catechol metabolites, which were generated by incubations with catechol-O-methyltransferase in vitro could be detected only in trace amounts in the urine samples. catechol 24-32 catechol-O-methyltransferase Homo sapiens 87-115 11294649-0 2001 Structural and functional consequences of inactivation of human glutathione S-transferase P1-1 mediated by the catechol metabolite of equine estrogens, 4-hydroxyequilenin. catechol 111-119 S100 calcium binding protein A10 Homo sapiens 90-94 11426700-3 2001 Optimum pH and optimum temperature values for LPO were determined for ABTS, p-phenylendiamine, catechol, epinephrine, and pyrogallol as substrates, and then Km and Vmax values for the same substrate were obtained by means of Lineweaver-Burk graphics. catechol 95-103 lactoperoxidase Bos taurus 46-49 11355744-0 2001 Effects of androgens and estrogens and catechol and methoxy-estrogen derivatives on mitogen-activated protein kinase (ERK(1,2)) activity in SW-13 human adrenal carcinoma cells. catechol 39-47 mitogen-activated protein kinase 3 Homo sapiens 118-125 11181039-1 2001 Recent studies have revealed that GSTM1 and M2 of the mu-class glutathione S-transferases catalyze a glutathione conjugate of catechol o-quinones including dopachrome, noradrenochrome, and adrenochrome under physiological conditions. catechol 126-134 glutathione S-transferase mu 1 Homo sapiens 34-39 11316576-0 2001 A catechol antioxidant protocatechuic acid potentiates inflammatory leukocyte-derived oxidative stress in mouse skin via a tyrosinase bioactivation pathway. catechol 2-10 tyrosinase Mus musculus 123-133 11990572-2 2001 The method involves the oxidation of o-dihydroxybenzene derivatives by K2CrO4 followed by oxidative coupling with sulfanilic acid (SPA), leading to the formation of a red or violet colored product having maximum absorbance at 490-495 nm for LD, MD and DP or at 560 nm for PC. catechol 272-274 surfactant protein A2 Homo sapiens 131-134 11223018-2 2001 Catechols are O-methylated by catechol-O-methyltransferase (COMT) in a SAM consuming reaction, preventing the initiation of catechol autoxidation. catechol 30-38 catechol-O-methyltransferase Homo sapiens 60-64 11421485-11 2001 The results thus demonstrated that dietary levels of 0.4% and 0.8% catechol long-term induce adenocarcinomas in the pyloric glands, while 0.1 and 0.2% cause benign proliferative lesions, all accompanied by increase in serum gastrin levels. catechol 67-75 gastrin Rattus norvegicus 224-231 11208799-11 2001 These novel characteristics of TetC thus differ significantly from results obtained from hitherto analyzed catechol 1,2-dioxygenases and chlorocatechol 1,2-dioxygenases. catechol 107-115 hypothetical protein Escherichia coli 31-35 11159850-12 2001 UGT2B4 demonstrates reactivity toward 5alpha-reduced androgens and catechol estrogens, but at a significantly lower level than UGT2B7, 2B15, and 2B17. catechol 67-75 UDP glucuronosyltransferase family 2 member B4 Homo sapiens 0-6 11160877-0 2001 Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase. catechol 61-69 catechol-O-methyltransferase Homo sapiens 101-129 11160877-8 2001 Among the catechol drugs used in the L-DOPA treatment of Parkinson"s disease, the COMT inhibitors entacapone and tolcapone were not methylated, whereas the DOPA decarboxylase inhibitor benserazide was 15 times more specific substrate than L-DOPA, the target of COMT inhibition. catechol 10-18 catechol-O-methyltransferase Homo sapiens 82-86 11314772-1 2001 Inhibition of catechol catechol-O-methyltransferase (COMT) in the brains of subjects treated with L-DOPA (L-3,4-dihydroxylphenylalanine) and an aromatic amino acid decarboxylase (AADC) inhibitor is suggested to cause an increase of L-DOPA, which might lead to oxidative damage through enhanced formation of free radicals. catechol 14-22 catechol-O-methyltransferase Rattus norvegicus 23-51 11156574-6 2001 Nevertheless, L-DOPA and two other substrates, namely, catechol and tyramine did produce nitric oxide from Angeli"s salt in the presence of tyrosinase, suggesting involvement of the respective unstable quinones. catechol 55-63 tyrosinase Rattus norvegicus 140-150 11314772-1 2001 Inhibition of catechol catechol-O-methyltransferase (COMT) in the brains of subjects treated with L-DOPA (L-3,4-dihydroxylphenylalanine) and an aromatic amino acid decarboxylase (AADC) inhibitor is suggested to cause an increase of L-DOPA, which might lead to oxidative damage through enhanced formation of free radicals. catechol 14-22 catechol-O-methyltransferase Rattus norvegicus 53-57 11314772-1 2001 Inhibition of catechol catechol-O-methyltransferase (COMT) in the brains of subjects treated with L-DOPA (L-3,4-dihydroxylphenylalanine) and an aromatic amino acid decarboxylase (AADC) inhibitor is suggested to cause an increase of L-DOPA, which might lead to oxidative damage through enhanced formation of free radicals. catechol 14-22 dopa decarboxylase Rattus norvegicus 179-183 11150922-5 2001 Masking of the 6,7-dihydroxy group of the catechol ring of 3",5"-diiodo-4"-acetamido analog of TMQ, a potent beta(1)- and beta(3)-AR agonist, abolished activity at both beta-AR subtypes. catechol 42-50 adrenoceptor beta 3 Homo sapiens 122-132 10950844-1 2000 In the present study, we evaluated the metabolic O-methylation of several catechol-containing tea polyphenols by human placental catechol-O-methyltransferase (COMT). catechol 74-82 catechol-O-methyltransferase Homo sapiens 129-157 11695449-7 2001 Reactions between ozone and adsorbed DHB were shown to be fast, leading to formation of C-6, C-4 and C-2 by-products. catechol 37-40 complement C6 Homo sapiens 88-91 11695449-7 2001 Reactions between ozone and adsorbed DHB were shown to be fast, leading to formation of C-6, C-4 and C-2 by-products. catechol 37-40 complement C4A (Rodgers blood group) Homo sapiens 93-96 11695449-7 2001 Reactions between ozone and adsorbed DHB were shown to be fast, leading to formation of C-6, C-4 and C-2 by-products. catechol 37-40 complement C2 Homo sapiens 101-104 11087502-6 2000 Maximum PPO activity was found with catechol (catecholase activity) followed by 4-methylcatechol. catechol 36-44 protoporphyrinogen oxidase Homo sapiens 8-11 11041870-4 2000 With this potential for directly probing the catechol binding region of the beta(2)AR, we synthesized and tested IAmF in carrier-free radioiodinated form ([(125)I]IAmF). catechol 45-53 adrenoceptor beta 2 Homo sapiens 76-85 11041870-7 2000 [(125)I]IAmF represents a new class of beta(2)AR photoaffinity labels that can directly probe the catechol-analogous antagonist pharmacophore binding site in the beta(2)AR ligand binding pocket. catechol 98-106 adrenoceptor beta 2 Homo sapiens 39-48 11041870-7 2000 [(125)I]IAmF represents a new class of beta(2)AR photoaffinity labels that can directly probe the catechol-analogous antagonist pharmacophore binding site in the beta(2)AR ligand binding pocket. catechol 98-106 adrenoceptor beta 2 Homo sapiens 162-171 10893236-2 2000 By using mRNA differential display technique, we show, herein, that estradiol-17beta (E(2)) and its catechol metabolite 4-hydroxy-E(2) (4OHE(2)) can modulate uterine gene expression in ERalpha(-/-) mice. catechol 100-108 estrogen receptor 1 (alpha) Mus musculus 185-192 11159850-10 2001 UGT2B7 was demonstrated to glucuronidate estrogens, catechol estrogens, and androstane-3alpha,17beta-diol more efficiently than any other human UGTB isoform. catechol 52-60 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 0-6 11142424-2 2000 This increased risk may be attributable to a decreased ability of the protein encoded by the low-activity allele (COMT(L)) to methylate and inactivate catechol estrogens, which have been implicated in estrogen carcinogenesis. catechol 151-159 catechol-O-methyltransferase Homo sapiens 114-118 11142424-5 2000 We also hypothesized that women who were both low-activity COMT genotype- and glutathione S-transferase (GST) M1- and/or T1 null would be at higher risk for ovarian cancer because the combination of these genotypes could theoretically lead to higher catechol estrogen exposure. catechol 250-258 catechol-O-methyltransferase Homo sapiens 59-63 11058906-1 2000 Catechol-O-methyltransferase (COMT) catalyses the O-methylation of neurotransmitters, catechol hormones and drugs such as levodopa and methyldopa. catechol 86-94 catechol-O-methyltransferase Homo sapiens 0-28 11058906-1 2000 Catechol-O-methyltransferase (COMT) catalyses the O-methylation of neurotransmitters, catechol hormones and drugs such as levodopa and methyldopa. catechol 86-94 catechol-O-methyltransferase Homo sapiens 30-34 10950844-1 2000 In the present study, we evaluated the metabolic O-methylation of several catechol-containing tea polyphenols by human placental catechol-O-methyltransferase (COMT). catechol 74-82 catechol-O-methyltransferase Homo sapiens 159-163 10950844-7 2000 In summary, several catechol-containing tea polyphenols are rapidly O-methylated by human placental cytosolic COMT. catechol 20-28 catechol-O-methyltransferase Homo sapiens 110-114 10826917-8 2000 Other MPO systems inactivating LADH were (a) MPO/H2O2/chlorpromazine; (b) MPO/H2O2/monophenolic systems, including L-tyrosine, serotonin and acetaminophen and (c) MPO/H2O2/di- and polyphenolic systems, including norepinephrine, catechol, nordihydroguaiaretic acid, caffeic acid, quercetin and catechin. catechol 228-236 myeloperoxidase Sus scrofa 6-9 10932071-8 2000 Catechol (50 micromol/L) inhibited production of IL-2 and IL-1beta by 62% to 73% but had little effect on TNF-alpha or IFN-gamma production. catechol 0-8 interleukin 2 Homo sapiens 49-53 10932071-8 2000 Catechol (50 micromol/L) inhibited production of IL-2 and IL-1beta by 62% to 73% but had little effect on TNF-alpha or IFN-gamma production. catechol 0-8 interleukin 1 beta Homo sapiens 58-66 10854207-1 2000 Catechol-O-methyltransferase (COMT) plays both a regulatory and protective role in catechol homeostasis. catechol 83-91 catechol-O-methyltransferase Homo sapiens 0-28 10854207-1 2000 Catechol-O-methyltransferase (COMT) plays both a regulatory and protective role in catechol homeostasis. catechol 83-91 catechol-O-methyltransferase Homo sapiens 30-34 10854207-10 2000 The focal nature of the phenomenon suggests that nuclear COMT does not serve a housekeeping function but that it reflects a protective response to an increased local catechol load, presumably of CEs and, as such, that it may be a characteristic of the population of women studied who share the same major risk factor for developing breast cancer, that of living in the industrialized West. catechol 166-174 catechol-O-methyltransferase Homo sapiens 57-61 10637135-0 2000 Catechol metabolites of polychlorinated biphenyls inhibit the catechol-O-methyltransferase-mediated metabolism of catechol estrogens. catechol 0-8 catechol-O-methyltransferase Rattus norvegicus 62-90 10835639-7 2000 We show that Th and Dbh deficiencies lead to reduced noradrenaline in the SNS, and that noradrenaline deficiency is a proximal cause of death in mutants by feeding catechol intermediates to pregnant dams, thereby partially averting Gata3 mutation-induced lethality. catechol 164-172 GATA binding protein 3 Mus musculus 232-237 10785817-1 2000 The enzyme catechol O-methyltransferase (COMT) catalyzes the Me group transfer from the cofactor S-adenosylmethionine (SAM) to the hydroxy group of catechol substrates. catechol 11-19 catechol-O-methyltransferase Rattus norvegicus 41-45 10637135-6 2000 In classical enzyme kinetics studies, COMT was demonstrated to have a high affinity for catechol PCBs, with K(m)"s approximately equivalent to those of CEs. catechol 88-96 catechol-O-methyltransferase Rattus norvegicus 38-42 10637136-3 2000 We hypothesize that PT-CAT inhibits the enzyme catechol-O-methyltransferase (COMT) and therefore potentiates genotoxicity by either PT-CAT itself or the endogenous catechol estrogens (CEs) in susceptible tissues. catechol 47-55 catechol-O-methyltransferase Mus musculus 77-81 10637136-8 2000 In vitro experiments demonstrated that PT treatment resulted in an increase in free CEs, which are normally cleared by COMT and a concurrent decrease in the capacity of hepatic catechol clearance by COMT. catechol 177-185 catechol-O-methyltransferase Mus musculus 199-203 10552767-5 1999 Raspberry PPO activity has pH optima of 8.0 and 5.5, both with catechol (0.1 M). catechol 63-71 protoporphyrinogen oxidase Homo sapiens 10-13 10552767-8 1999 Ceva and Autumm Bliss raspberries showed the higher PPO activity using catechol as substrate. catechol 71-79 protoporphyrinogen oxidase Homo sapiens 52-55 11041870-1 2000 To develop molecules capable of directly probing the catechol binding region of the beta(2)-adrenergic receptor (beta(2)AR), novel benzophenone- and fluorenone-based beta(2)AR antagonists were prepared as potential photoaffinity probes. catechol 53-61 adrenoceptor beta 2 Homo sapiens 84-111 11041870-1 2000 To develop molecules capable of directly probing the catechol binding region of the beta(2)-adrenergic receptor (beta(2)AR), novel benzophenone- and fluorenone-based beta(2)AR antagonists were prepared as potential photoaffinity probes. catechol 53-61 adrenoceptor beta 2 Homo sapiens 113-122 10888500-2 2000 The inhibitory pattern on catechol-PPO model system appeared to be competitive, with a K(i) value of 2.0 mM. catechol 26-34 protoporphyrinogen oxidase Homo sapiens 35-38 10787090-6 2000 However, in tyrosinase-mediated reactions controlled by nucleophilic addition, catechol enhanced the dehalogenation of most of the chlorophenols, whereas syringaldehyde had little effect. catechol 79-87 tyrosinase Homo sapiens 12-22 10764452-12 2000 Strikingly elevated CYP1A1 transcripts in endometriosis may give rise to significantly increased P-4501A1 enzyme activity and thus promote the development and growth of endometriosis by either activating procarcinogens or inducing the formation of catechol estrogens or both. catechol 248-256 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 10677273-6 2000 In this model the unusual autoactivation kinetics of tyrosinase are explained by recruitment of enzyme from the met -form, in which the active-site copper atoms are in the oxidized (Cu(II)) state, by 2-electron donation from catechol oxidation. catechol 225-233 tyrosinase Homo sapiens 53-63 10698790-3 2000 Washed-cell suspensions of strain GCH1 accumulated N-isopropylacetanilide, acetanilide, acetamide, and catechol. catechol 103-111 GTP cyclohydrolase 1 Homo sapiens 34-38 10719200-5 2000 Type I, or meta-meta type (15 strains), was characterized by meta cleavage of catechol by catechol 2,3-dioxygenase (C23O) during the growth on phenol and p-cresol. catechol 78-86 catechol 2,3-dioxygenase Pseudomonas putida 90-114 10719200-5 2000 Type I, or meta-meta type (15 strains), was characterized by meta cleavage of catechol by catechol 2,3-dioxygenase (C23O) during the growth on phenol and p-cresol. catechol 78-86 catechol 2,3-dioxygenase Pseudomonas putida 116-120 10667565-0 2000 Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens. catechol 52-60 CD1 antigen complex Mus musculus 39-43 11196809-0 2000 Pentadentate terpyridine-catechol linked ligands and their cobalt(III) complexes. catechol 25-33 mitochondrially encoded cytochrome c oxidase III Homo sapiens 66-69 10497143-7 1999 The catalytic activity of stably expressed UGT1A8 toward catechol estrogens, coumarins, flavonoids, anthraquinones, and phenolic compounds was much higher than that of UGT1A10. catechol 57-65 UDP glucuronosyltransferase family 1 member A8 Homo sapiens 43-49 10497143-7 1999 The catalytic activity of stably expressed UGT1A8 toward catechol estrogens, coumarins, flavonoids, anthraquinones, and phenolic compounds was much higher than that of UGT1A10. catechol 57-65 UDP glucuronosyltransferase family 1 member A10 Homo sapiens 168-175 10637135-2 2000 Methylation by catechol-O-methyltransferase (COMT) is the principal means of catechol estrogen (CE) deactivation in the liver and other tissues. catechol 15-23 catechol-O-methyltransferase Rattus norvegicus 45-49 10637135-3 2000 The present studies were conducted to determine the effects of PCBs and catechol metabolites of PCBs on the COMT-mediated catabolism of 4-OHE(2) and 2-OHE(2) in vitro and in vivo. catechol 72-80 catechol-O-methyltransferase Rattus norvegicus 108-112 10385691-3 1999 We found that the antioxidants nordihydroguaiaretic acid (NDGA), catechol, glutaryl probucol, and N-acetylcysteine increased eNOS expression in cultured bovine aortic endothelial cells (BAECs). catechol 65-73 nitric oxide synthase 3 Bos taurus 125-129 10462055-4 1999 This study followed the ability of quinonic benzene metabolites (catechol, hydroquinone, and benzoquinone) to destroy CYP in liver microsomes from rats pretreated with various inducers and in human liver microsomes. catechol 65-73 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 118-121 10410961-1 1999 Catechol-O-methyltransferase (COMT) exists as two isoenzymes, a membrane-bound form (MB-COMT) and a soluble form (S-COMT), with different roles in the metabolism of catecholamines and other catechol compounds. catechol 165-173 catechol-O-methyltransferase Rattus norvegicus 0-28 10410961-1 1999 Catechol-O-methyltransferase (COMT) exists as two isoenzymes, a membrane-bound form (MB-COMT) and a soluble form (S-COMT), with different roles in the metabolism of catecholamines and other catechol compounds. catechol 165-173 catechol-O-methyltransferase Rattus norvegicus 30-34 10410961-1 1999 Catechol-O-methyltransferase (COMT) exists as two isoenzymes, a membrane-bound form (MB-COMT) and a soluble form (S-COMT), with different roles in the metabolism of catecholamines and other catechol compounds. catechol 165-173 catechol-O-methyltransferase Rattus norvegicus 88-92 10410961-1 1999 Catechol-O-methyltransferase (COMT) exists as two isoenzymes, a membrane-bound form (MB-COMT) and a soluble form (S-COMT), with different roles in the metabolism of catecholamines and other catechol compounds. catechol 165-173 catechol-O-methyltransferase Rattus norvegicus 88-92 10067811-2 1999 Cytochrome P450 1B1 (CYP1B1) is a dioxin-inducible gene that is active in the formation of 4-hydroxyestradiol, a potentially genotoxic catechol estrogen. catechol 135-143 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 10485826-6 1999 Only slight expression of c-myc or c-fos was apparent after 30-min oral administration or 1-, 3-, and 6-hr oral administration of catechol. catechol 130-138 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 26-31 10485826-6 1999 Only slight expression of c-myc or c-fos was apparent after 30-min oral administration or 1-, 3-, and 6-hr oral administration of catechol. catechol 130-138 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 35-40 10347189-2 1999 Here we evaluated Phe310, Phe311, and Phe303 in transmembrane VI (TMVI), as well as Tyr348 in TMVII of the alpha1B-adrenergic receptor (alpha1B-AR), which have been implicated in a catechol-ring interaction. catechol 181-189 adrenoceptor alpha 1B Homo sapiens 107-134 10208303-7 1999 In addition, replacement of the 8-hydroxycarbostyril nucleus of 11a with catechol reduced the affinity of the compound for the beta2AR by 48-fold and increased its k(off). catechol 73-81 beta-2 adrenergic receptor Mesocricetus auratus 127-134 10067811-2 1999 Cytochrome P450 1B1 (CYP1B1) is a dioxin-inducible gene that is active in the formation of 4-hydroxyestradiol, a potentially genotoxic catechol estrogen. catechol 135-143 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 10499098-0 1999 Catechol(amine)s as probes of lactoperoxidase catalytic site structure: spectroscopic and modeling studies. catechol 0-8 lactoperoxidase Homo sapiens 30-45 9925803-2 1999 Although catechol estrogens exhibit weak estrogenic activity, the catechol PCB metabolites which are structurally similar to these ER agonists have gone untested for potential estrogenicity. catechol 66-74 estrogen receptor 1 Homo sapiens 131-133 9922163-0 1998 Structural and thermochemical characterization of lipoxygenase-catechol complexes. catechol 63-71 linoleate 9S-lipoxygenase-4 Glycine max 50-62 9789061-3 1998 CYP3A metabolism generates epipodophyllotoxin catechol and quinone metabolites, which could damage DNA. catechol 46-54 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-5 9843368-0 1998 Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution. catechol 93-101 phenylalanine hydroxylase Homo sapiens 39-64 9843368-2 1998 Here we present the crystal structure of the dimeric catalytic domain (residues 117-424) of human phenylalanine hydroxylase (hPheOH), cocrystallized with various potent and well-known catechol inhibitors and refined at a resolution of 2.0 A. catechol 184-192 phenylalanine hydroxylase Homo sapiens 98-123 9855007-2 1998 Methylation by COMT is the principal pathway for inactivation of catechol estrogens, which are hypothesized to participate in estrogen-induced carcinogenesis. catechol 65-73 catechol-O-methyltransferase Homo sapiens 15-19 9714320-5 1998 However, the rate constant of these catechol derivatives in scavenging hydroxyl radicals was < 10(10) M(-1) sec(-1), suggesting that they may not protect against biological damage induced by hydroxyl radicals. catechol 36-44 secretory blood group 1, pseudogene Homo sapiens 111-117 9705221-4 1998 Transiently expressed human UGT1A8 shows glucuronidation activities with coumarins, anthraquinones, flavonoids, phenolic compounds, catechol estrogens, 17-hydroxyandrogens, primary amines such as the carcinogen 4-aminobiphenyl, and certain opioids. catechol 132-140 UDP glucuronosyltransferase family 1 member A8 Homo sapiens 28-34 9677336-11 1998 The deduced amino acid sequence of the enzyme has 56% and 75% identity with the catechol 1, 2-dioxygenases of Arthrobacter mA3 and Rhodococcus erythropolis AN-13 respectively, but less than 35% identity with intradiol catechol and chlorocatechol dioxygenases of Gram-negative bacteria. catechol 80-88 olfactory receptor family 2 subfamily B member 4 Mus musculus 123-126 9848110-3 1998 Three human liver UDP-glucuronosyltransferases, UGT2B7, UGT1A1, and UGT1A3, have been shown to catalyze the glucuronidation of catechol estrogens and lead to their enhanced elimination via urine or bile. catechol 127-135 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 48-54 9848110-3 1998 Three human liver UDP-glucuronosyltransferases, UGT2B7, UGT1A1, and UGT1A3, have been shown to catalyze the glucuronidation of catechol estrogens and lead to their enhanced elimination via urine or bile. catechol 127-135 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 56-62 9848110-3 1998 Three human liver UDP-glucuronosyltransferases, UGT2B7, UGT1A1, and UGT1A3, have been shown to catalyze the glucuronidation of catechol estrogens and lead to their enhanced elimination via urine or bile. catechol 127-135 UDP glucuronosyltransferase family 1 member A3 Homo sapiens 68-74 9848110-7 1998 UGT2B7(H) catalyzed estrogen catechol glucuronidation with efficiencies similar to UGT2B7(Y). catechol 29-37 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 0-6 9848110-8 1998 Flunitrazepam (FNZ), a competitive inhibitor of morphine glucuronidation in hepatic microsomes, competitively inhibited catechol estrogen glucuronidation catalyzed by UGT2B7(Y), UGT1A1, and UGT1A3. catechol 120-128 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 167-173 9848110-8 1998 Flunitrazepam (FNZ), a competitive inhibitor of morphine glucuronidation in hepatic microsomes, competitively inhibited catechol estrogen glucuronidation catalyzed by UGT2B7(Y), UGT1A1, and UGT1A3. catechol 120-128 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 178-184 9848110-8 1998 Flunitrazepam (FNZ), a competitive inhibitor of morphine glucuronidation in hepatic microsomes, competitively inhibited catechol estrogen glucuronidation catalyzed by UGT2B7(Y), UGT1A1, and UGT1A3. catechol 120-128 UDP glucuronosyltransferase family 1 member A3 Homo sapiens 190-196 9760135-1 1998 Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a ubiquitous enzyme crucial to catechol metabolism. catechol 82-90 catechol-O-methyltransferase Homo sapiens 0-28 9760135-1 1998 Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a ubiquitous enzyme crucial to catechol metabolism. catechol 82-90 catechol-O-methyltransferase Homo sapiens 30-34 9871776-1 1998 Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. catechol 204-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 9871776-2 1998 From the modeling studies, the catechol analogue appeared capable of replacing one of the crystallographic waters bridging huperzine with Tyr 130 and Glu 199 of AChE. catechol 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 9607801-0 1998 Differential spatiotemporal regulation of lactoferrin and progesterone receptor genes in the mouse uterus by primary estrogen, catechol estrogen, and xenoestrogen. catechol 127-135 lactotransferrin Mus musculus 42-53 9714305-7 1998 When reconstituted CYP3A4 was added to an ongoing incubation containing reconstituted 2C19, stimulation of catechol formation occurred. catechol 107-115 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 19-25 9714305-9 1998 Cumulative evidence demonstrates that the stimulation of catechol formation resulted from CYP3A4-mediated ortho-hydroxylation of the phenolic metabolite(s) generated by CYP2C19. catechol 57-65 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 90-96 9714305-9 1998 Cumulative evidence demonstrates that the stimulation of catechol formation resulted from CYP3A4-mediated ortho-hydroxylation of the phenolic metabolite(s) generated by CYP2C19. catechol 57-65 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 169-176 9622057-1 1998 Catechol estrogens (2- or 4-hydroxyestradiol and 2- or 4-hydroxyestrone) are chemically reactive estrogen metabolites that are O-methylated to less polar monomethyl ethers by catechol-O-methyltransferase, an enzyme present in many tissues such as the liver, kidney, brain, placenta, uterus, and mammary gland. catechol 0-8 catechol-O-methyltransferase Homo sapiens 175-203 9607801-0 1998 Differential spatiotemporal regulation of lactoferrin and progesterone receptor genes in the mouse uterus by primary estrogen, catechol estrogen, and xenoestrogen. catechol 127-135 progesterone receptor Mus musculus 58-79 11670388-8 1998 These data are consistent with a simple Cr(III)-catechol formulation (S = (3)/(2)) in the case of [Cr(tren)(3,6-DTBCat)](PF(6)) and strong antiferromagnetic coupling ( J > 350 cm(-)(1)) between the Cr(III) and the semiquinone radical in [Cr(tren)(3,6-DTBSQ)](PF(6))(2). catechol 48-56 sperm associated antigen 17 Homo sapiens 121-126 9600061-1 1998 2-Hydroxymuconic semialdehyde dehydrogenase catalyzes the conversion of 2-hydroxymuconic semialdehyde (HMS) to an enol form of 4-oxalocrotonate which is a step in the catechol meta-cleavage pathway. catechol 167-175 2-hydroxymuconic semialdehyde dehydrogenase Achromobacter xylosoxidans 0-43 11670388-8 1998 These data are consistent with a simple Cr(III)-catechol formulation (S = (3)/(2)) in the case of [Cr(tren)(3,6-DTBCat)](PF(6)) and strong antiferromagnetic coupling ( J > 350 cm(-)(1)) between the Cr(III) and the semiquinone radical in [Cr(tren)(3,6-DTBSQ)](PF(6))(2). catechol 48-56 sperm associated antigen 17 Homo sapiens 263-268 9749372-2 1998 In contrast, many catechol derivatives possessing electronegative substituents are potent COMT inhibitors. catechol 18-26 catechol-O-methyltransferase Homo sapiens 90-94 9545294-1 1998 Catechol 2,3-dioxygenase (XylE) is a component of the TOL plasmid-encoded pathway for the degradation of toluene and xylenes and catalyzes the dioxygenolytic cleavage of the aromatic ring. catechol 0-8 catechol 2,3-dioxygenase Pseudomonas putida 26-30 9545294-2 1998 Purified XylE is oxygen-sensitive and unstable in vitro, particularly in the presence of substituted catechol substrates, but it is stabilized in vivo by another protein, XylT, encoded by the xylT gene located just upstream of xylE. catechol 101-109 catechol 2,3-dioxygenase Pseudomonas putida 9-13 9511473-5 1998 The second enzyme, tyrosinase, then oxidizes the catechol to o-quinone, which is electrochemically detected and reduced back to catechol at the electrode at an Eappl = -50 mV vs Ag/AgCl. catechol 49-57 tyrosinase Homo sapiens 19-29 9511473-5 1998 The second enzyme, tyrosinase, then oxidizes the catechol to o-quinone, which is electrochemically detected and reduced back to catechol at the electrode at an Eappl = -50 mV vs Ag/AgCl. catechol 128-136 tyrosinase Homo sapiens 19-29 9511473-6 1998 This results in an amplified signal due to the recycling of the catechol and o-quinone between tyrosinase and the surface of the electrode. catechol 64-72 tyrosinase Homo sapiens 95-105 9626967-4 1998 The maximum reduction of NOP formation (7% of the yield obtained under control conditions) was produced at 120 min by 40 mM 1,2-benzenediol. catechol 124-139 prepronociceptin Homo sapiens 25-28 9440817-9 1998 Our results support the hypothesis that the ligand-binding pocket in the GHS-R is spatially disposed similarly to the well characterized catechol-binding site in the beta2-adrenergic receptor. catechol 137-145 growth hormone secretagogue receptor Homo sapiens 73-78 9749372-1 1998 Catechol and endogenous catechol derivatives are readily methylated by catechol O-methyltransferase (COMT). catechol 0-8 catechol-O-methyltransferase Homo sapiens 71-99 9749372-1 1998 Catechol and endogenous catechol derivatives are readily methylated by catechol O-methyltransferase (COMT). catechol 0-8 catechol-O-methyltransferase Homo sapiens 101-105 9749372-1 1998 Catechol and endogenous catechol derivatives are readily methylated by catechol O-methyltransferase (COMT). catechol 24-32 catechol-O-methyltransferase Homo sapiens 71-99 9749372-1 1998 Catechol and endogenous catechol derivatives are readily methylated by catechol O-methyltransferase (COMT). catechol 24-32 catechol-O-methyltransferase Homo sapiens 101-105 9443856-3 1998 UGT2B7 has been shown to catalyze NSAIDs, catechol estrogens, and morphine-3- and -6-glucuronidation. catechol 42-50 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 0-6 9440817-9 1998 Our results support the hypothesis that the ligand-binding pocket in the GHS-R is spatially disposed similarly to the well characterized catechol-binding site in the beta2-adrenergic receptor. catechol 137-145 adrenoceptor beta 2 Homo sapiens 166-191 9305589-1 1997 The cytochrome P450-dependent covalent binding of radiolabel derived from phenytoin (DPH) and its phenol and catechol metabolites, 5-(4"-hydroxyphenyl)-5-phenylhydantoin (HPPH) and 5-(3",4"-dihydroxyphenyl)-5-phenylhydantoin (CAT), was examined in liver microsomes. catechol 109-117 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-19 9407957-2 1997 O-Methylation, catalyzed by catechol-O-methyltransferase (COMT), inactivates catechol estrogens. catechol 28-36 catechol-O-methyltransferase Homo sapiens 58-62 9299189-2 1997 Exposure of human T lymphoblasts (HTL) in vitro to 50 microM HQ or 50 microM catechol decreased IL-2-dependent DNA synthesis and cell proliferation by >90% with no effect on cell viability. catechol 77-85 interleukin 2 Homo sapiens 96-100 9219504-8 1997 RESULTS: Relative to their untreated counterparts, MCF-7/0 and MCF-7/OAP cells treated with 3-methylcholanthrene or catechol transiently expressed elevated levels of cytosolic class 3 aldehyde dehydrogenase, glutathione S-transferase, DT-diaphorase and UDP-glucuronosyl transferase, and were transiently, more resistant to mafosfamide, melphalan, and mitoxantrone, and more sensitive to EO9. catechol 116-124 glutathione S-transferase kappa 1 Homo sapiens 208-233 9085193-6 1997 With and without catechol structure, the oxidized isoquinolinium ion having methyl groups at C-1 and N-2 positions proved to be more cytotoxic than the simple isoquinolines. catechol 17-25 heterogeneous nuclear ribonucleoprotein C Homo sapiens 93-96 9219504-8 1997 RESULTS: Relative to their untreated counterparts, MCF-7/0 and MCF-7/OAP cells treated with 3-methylcholanthrene or catechol transiently expressed elevated levels of cytosolic class 3 aldehyde dehydrogenase, glutathione S-transferase, DT-diaphorase and UDP-glucuronosyl transferase, and were transiently, more resistant to mafosfamide, melphalan, and mitoxantrone, and more sensitive to EO9. catechol 116-124 NAD(P)H quinone dehydrogenase 1 Homo sapiens 235-248 8654195-2 1995 To test this notion, relatively large and approximately equal amounts of human normal stomach mucosa ALDH-3 and catechol-induced human breast adenocarcinoma MCF-7/0 ALDH-3 were first electroporated into cells (MCF-7/0) that constitutively express only very small amounts of the enzyme. catechol 112-120 aldehyde dehydrogenase 3 family member A1 Homo sapiens 165-171 8652659-2 1996 We show that the ARE (TGACNNNGCA) is required for induction by redox cycling phenolics (p-benzoquinone, catechol and hydroquinone), which are monofunctional inducers and induce NQO1 without the requirement for activation by cytochrome P-450. catechol 104-112 NAD(P)H quinone dehydrogenase 1 Homo sapiens 177-181 8672242-1 1996 The methylating enzyme catechol-O-methyltransferase (COMT) is an important inactivator of substrates containing catechol-structure, such as catechol neurotransmitters and hormones. catechol 23-31 catechol-O-methyltransferase Rattus norvegicus 53-57 8672242-1 1996 The methylating enzyme catechol-O-methyltransferase (COMT) is an important inactivator of substrates containing catechol-structure, such as catechol neurotransmitters and hormones. catechol 112-120 catechol-O-methyltransferase Rattus norvegicus 23-51 8672242-1 1996 The methylating enzyme catechol-O-methyltransferase (COMT) is an important inactivator of substrates containing catechol-structure, such as catechol neurotransmitters and hormones. catechol 112-120 catechol-O-methyltransferase Rattus norvegicus 53-57 8807664-1 1996 Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. catechol 48-56 catechol-O-methyltransferase Homo sapiens 0-28 8807664-1 1996 Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. catechol 48-56 catechol-O-methyltransferase Homo sapiens 30-34 21619127-0 1996 Rate-limiting steps of tyrosinase-modified electrodes for the detection of catechol. catechol 75-83 tyrosinase Homo sapiens 23-33 21619127-1 1996 The response currents obtained for tyrosinase-modified Teflon/graphite, carbon paste, and solid graphite electrodes in the presence of catechol are analyzed primarily using rotating disk electrode experiments. catechol 135-143 tyrosinase Homo sapiens 35-45 8640815-7 1996 Another metabolite of 4-OH-tam, assumed to be 3,4-dihydroxytamoxifen (3,4-di-OH-tam) catechol, was demonstrated by its monomethylation with [3H]S-adenosyl-L-methionine ([3H]SAM) in presence of endogenous catechol-O-methyltransferase. catechol 85-93 catechol-O-methyltransferase Rattus norvegicus 204-232 8626427-12 1996 Furthermore, since Ser188 and Ser192 are separated by three residues on the TMV alpha-helix, whereas Ser204 and Ser207 of the beta2-AR are separated by only two residues, the orientation of the catechol ring in the alpha1-AR binding pocket appears to be unique and rotated approximately 120 degrees to that in the beta2-AR. catechol 194-202 adrenoceptor beta 2 Homo sapiens 126-134 9118895-4 1996 The ability of benzene metabolites to destroy liver microsomal CYP in vitro decreased in the order BQ > HQ > catechol > phenol. catechol 115-123 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 63-66 8694255-4 1996 Phenol is oxidized in the sensor membrane by the oxygen-consuming tyrosinase via catechol to o-quinone. catechol 81-89 tyrosinase Homo sapiens 66-76 8694255-5 1996 The quinone is reconverted to catechol by glucose dehydrogenase. catechol 30-38 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 42-63 8930523-3 1996 Some investigators suggested the effect of catechol estrogen on human placental steroidogenesis which may be related to pregnancy-induced hypertension (PIH) through the inhibition of catechol-O-methyltransferase (COMT) activity. catechol 43-51 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 152-155 8930523-3 1996 Some investigators suggested the effect of catechol estrogen on human placental steroidogenesis which may be related to pregnancy-induced hypertension (PIH) through the inhibition of catechol-O-methyltransferase (COMT) activity. catechol 43-51 catechol-O-methyltransferase Homo sapiens 183-211 8930523-3 1996 Some investigators suggested the effect of catechol estrogen on human placental steroidogenesis which may be related to pregnancy-induced hypertension (PIH) through the inhibition of catechol-O-methyltransferase (COMT) activity. catechol 43-51 catechol-O-methyltransferase Homo sapiens 213-217 8561793-1 1996 The salicylate hydroxylase, a flavoprotein monooxygenase, catalyzes the decarboxylative hydroxylation of salicylate to form catechol. catechol 124-132 salicylate hydroxylase Pseudomonas putida 4-26 9199118-2 1996 The aim of the presented study is to evaluate the linear correlation between: 1) serum dopamine-beta hydroxylase activity and the dopamine concentration in plasma as well as 24-hours adrenaline and noradrenaline excretion in the urine; and 2) between catechol-0-methyltransferase and monoaminoxidase activity and the 24-hours excretion of catecholamine in the urine; next the serum and platelet concentration of serotonin and the arterial blood pressure in women chronically exposed to carbon disulfide. catechol 251-259 dopamine beta-hydroxylase Homo sapiens 87-112 8689949-1 1995 Flavin-containing monooxygenase-1 (FMO1) purified to homogeneity from pig liver microsomes catalyzes NADPH- and oxygen-dependent oxidation of salicylaldehyde to pyrocatechol and formate. catechol 161-173 flavin containing dimethylaniline monoxygenase 1 Sus scrofa 0-33 8689949-1 1995 Flavin-containing monooxygenase-1 (FMO1) purified to homogeneity from pig liver microsomes catalyzes NADPH- and oxygen-dependent oxidation of salicylaldehyde to pyrocatechol and formate. catechol 161-173 flavin containing dimethylaniline monoxygenase 1 Sus scrofa 35-39 7578137-0 1995 Structure and kinetics of formation of catechol complexes of ferric soybean lipoxygenase-1. catechol 39-47 seed linoleate 13S-lipoxygenase-1 Glycine max 76-90 7592763-7 1995 The results suggest that by analogy to receptors and plasma membrane transporters for monoamines, the cationic amino group of the ligand interacts with an asparte in the first transmembrane domain of VMAT2 and hydroxyl groups on the catechol or indole ring interact with a group of serines in the third transmembrane domain. catechol 233-241 solute carrier family 18 member A2 Homo sapiens 200-205 8593536-1 1995 NADPH-cytochrome1 P450 reductase and DT-diaphorase catalyze and one- and two-electron reduction of adrenochrome to its o-semiquinone and o-hydroquinone, respectively. catechol 137-151 2,4-dienoyl-CoA reductase 1 Homo sapiens 0-5 8593536-1 1995 NADPH-cytochrome1 P450 reductase and DT-diaphorase catalyze and one- and two-electron reduction of adrenochrome to its o-semiquinone and o-hydroquinone, respectively. catechol 137-151 NAD(P)H quinone dehydrogenase 1 Homo sapiens 37-50 8593536-2 1995 Under aerobic conditions both adrenochrome o-semiquinone and o-hydroquinone proved to be unstable, undergoing autoxidation with concomitant oxygen consumption and continuous NADPH and NADH oxidation. catechol 61-75 2,4-dienoyl-CoA reductase 1 Homo sapiens 174-179 8654195-4 1995 ALDH-3 activities (NADP-dependent catalysis of benzaldehyde oxidation) were 1.7, 212, and 183 mlU/10(7) cells in sham-electroporated MCF-7/0 cells, and MCF-7/0 cells electroporated with stomach mucosa ALDH-3 and catechol-induced MCF-7/0 ALDH-3, respectively. catechol 212-220 aldehyde dehydrogenase 3 family member A1 Homo sapiens 0-6 7727409-2 1995 The resonance Raman spectra of hTH1 complexed with dopamine, noradrenaline, tyramine, and catechol have been studied and compared to those obtained for TH isolated from bovine adrenal glands or rat phaeochromocytoma tissue. catechol 90-98 negative elongation factor complex member C/D Homo sapiens 31-35 7542701-5 1995 Structure-activity analysis suggests that effective aFGF partners all contain an amine group separated from a catechol nucleus by two carbons. catechol 110-118 fibroblast growth factor 1 Mus musculus 52-56 7794247-1 1995 The salicylate hydroxylase can convert the salicylate to catechol, and catechol 2,3-dioxygenase catalizes the conversion of catechol to 2-hydroxymuconic semialdehyde. catechol 57-65 salicylate hydroxylase Pseudomonas putida 4-26 7794247-1 1995 The salicylate hydroxylase can convert the salicylate to catechol, and catechol 2,3-dioxygenase catalizes the conversion of catechol to 2-hydroxymuconic semialdehyde. catechol 71-79 salicylate hydroxylase Pseudomonas putida 4-26 7769228-8 1995 Immunolocalization of P450arom in the equine testicular Leydig cells and in ovarian granulosa and luteinized cells indicates that these cells have the ability to metabolize androgens to estrogens and possibly to catechol estrogens. catechol 212-220 cytochrome P450 family 19 subfamily A member 1 Equus caballus 22-30 7607477-1 1995 M.HhaI, M.TaqI and COMT are DNA methyltransferases (MTases) which catalyze the transfer of a methyl group from the cofactor AdoMet to C5 of cytosine, to N6 of adenine and to a hydroxyl group of catechol, respectively. catechol 194-202 catechol-O-methyltransferase Homo sapiens 19-23 7829267-0 1995 Catechol interferes with TGF-beta-induced elimination of transformed cells by normal cells: implications for the survival of transformed cells during carcinogenesis. catechol 0-8 transforming growth factor beta 1 Homo sapiens 25-33 7748896-2 1995 Anaerobic reactions of inhibitor-treated laccase and ascorbate oxidase with pyrocatechol and L-ascorbate, respectively, gave EPR signals originating from the inhibitor-bound type 3 copper, except for the case of F(-)-laccase. catechol 76-88 L-ascorbate oxidase Cucumis sativus 53-70 7744021-1 1995 The substrate specificities of two catechol 2,3-dioxygenases, one encoded by xylE on the TOL plasmid pWW0 and the other encoded by nahH on the NAH7 plasmid, were investigated. catechol 35-43 catechol 2,3-dioxygenase Pseudomonas putida 77-81 7744021-2 1995 The XylE catechol 2,3-dioxygenase catalyzes the ring-cleavage of catechol, 3-methylcatechol and 4-methylcatechol. catechol 9-17 catechol 2,3-dioxygenase Pseudomonas putida 4-8 7897657-1 1995 The DNA methyltransferases, M.HhaI and M.TaqI, and catechol O-methyl-transferase (COMT) catalyze the transfer of a methyl group from the cofactor S-adenosyl-L-methionine (AdoMet) to carbon-5 of cytosine, to nitrogen-6 of adenine, and to a hydroxyl group of catechol, respectively. catechol 51-59 catechol-O-methyltransferase Homo sapiens 82-86 7887982-1 1995 High-level cytosolic class-3 aldehyde dehydrogenase (ALDH-3)-mediated oxazaphosphorine-specific resistance (> 35-fold as judged by the concentrations of mafosfamide required to effect a 90% cell-kill) was induced in cultured human breast adenocarcinoma MCF-7/0 cells by growing them in the presence of 30 microM catechol for 5 days. catechol 315-323 aldehyde dehydrogenase 3 family member A1 Homo sapiens 53-59 7887982-7 1995 Cellular levels of ALDH-3 activity were also increased when a number of other human tumor cell lines, e.g. breast adenocarcinoma MDA-MB-231, breast carcinoma T-47D and colon carcinoma HCT 116b, were cultured in the presence of catechol. catechol 227-235 aldehyde dehydrogenase 3 family member A1 Homo sapiens 19-25 7829267-4 1995 Catechol and hydroquinone, but not resorcinol, were found to represent potent antagonists of TGF-beta-induced elimination of transformed cells by normal cells. catechol 0-8 transforming growth factor beta 1 Homo sapiens 93-101 7765392-2 1994 Catechol 2,3-dioxygenase encoded by phe B showed similar substrate specificity to that of xyl E. However, Phe B has much smaller Km values than Xyl E, indicating that Phe B is useful for treatment of low concentrations of catechol derivatives in waste water. catechol 222-230 catechol 2,3-dioxygenase Pseudomonas putida 0-24 8728769-2 1995 Inactivation of lipoamide dehydrogenase (LipDH) by the Cu(II)/H2O2 Fenton system (SF-Cu(II): (5.0 microM Cu(II), 3.0 mM H2O2) was enhanced by catecholamines (CAs), namely, epinephrine, levoDOPA (DOPA), DOPAMINE, 6-hydroxyDOPAMINE (OH-DOPAMINE) and related compounds (DOPAC, CATECHOL, etc.). catechol 274-282 dihydrolipoamide dehydrogenase Homo sapiens 16-39 27414180-1 1994 One-electron reduction of noradrenochrome catalyzed by NADPH-cytochrome P-450 reductase resulted primarily in the formation of o-semiquinone and, probably, also o-hydroquinone. catechol 161-175 cytochrome p450 oxidoreductase Homo sapiens 55-87 7944370-5 1994 Results obtained from experiments with dense cell suspensions of strain Cat2 demonstrated that all enzymes necessary for protocatechuate and benzoate degradation were induced during growth with catechol. catechol 194-202 solute carrier family 7 member 2 Homo sapiens 72-76 7944370-9 1994 strain Cat2, protocatechuyl-coenzyme A (CoA) was formed from catechol, bicarbonate, and uncombined CoA. catechol 61-69 solute carrier family 7 member 2 Homo sapiens 7-11 7923572-10 1994 Both hydroquinone and catechol formation showed a direct correlation with CYP 2E1 activity over the range of activities present. catechol 22-30 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 74-81 7812764-9 1994 These results indicated that the catechol structure recognized and combined with TPH at a binding site different from that of the substrate or cofactor and the positive charge on the dopamine-derived substance enhanced the affinity to TPH. catechol 33-41 tryptophan hydroxylase 1 Rattus norvegicus 81-84 8079344-5 1994 Intracellular catechol levels in CHO/AADC cells were double those in CHO/WT cultures. catechol 14-22 dopa decarboxylase Bos taurus 37-41 8079344-9 1994 Although CHO/AADC cultures were more sensitive than CHO/WT to L-dopa and Mn, this was completely accounted for by the differences in intracellular catechol levels between the two cell lines. catechol 147-155 dopa decarboxylase Bos taurus 13-17 7812764-9 1994 These results indicated that the catechol structure recognized and combined with TPH at a binding site different from that of the substrate or cofactor and the positive charge on the dopamine-derived substance enhanced the affinity to TPH. catechol 33-41 tryptophan hydroxylase 1 Rattus norvegicus 235-238 8027527-14 1994 The wide distribution of COMT in different tissues suggests an important role for this protein in inactivation of catechol compounds. catechol 114-122 catechol-O-methyltransferase Rattus norvegicus 25-29 7820101-0 1994 Binding of a catechol derivative of denopamine (T-0509) and N-tert-butylnoradrenaline (Colterol) to beta 1- and beta 2-adrenoceptors. catechol 13-21 beta-2 adrenergic receptor Cavia porcellus 100-132 8019435-0 1994 Inhibition of NF-kappa B transcription factor by catechol derivatives. catechol 49-57 nuclear factor kappa B subunit 1 Homo sapiens 14-24 7996385-1 1994 Catechol-O-methyltransferase (COMT) catalyses the transfer of the methyl group from S-adenyl-L-methionine (SAM) to one of the hydroxy groups of a catechol, usually the hydroxy group in position 3. catechol 146-154 catechol-O-methyltransferase Rattus norvegicus 0-28 7996385-1 1994 Catechol-O-methyltransferase (COMT) catalyses the transfer of the methyl group from S-adenyl-L-methionine (SAM) to one of the hydroxy groups of a catechol, usually the hydroxy group in position 3. catechol 146-154 catechol-O-methyltransferase Rattus norvegicus 30-34 7996385-3 1994 MB-COMT has higher affinity for the catechol substrate than does S-COMT by a factor of > 10, and high MB-COMT activity is observed in the intestinal muscle layer. catechol 36-44 catechol-O-methyltransferase Rattus norvegicus 3-7 8031317-3 1994 In this paper we followed the ability of benzene and its metabolites, phenol, catechol, hydroquinone and benzoquinone to destroy CYP in liver microsomes from PB rats in vitro. catechol 78-86 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 129-132 8031317-5 1994 (2) Quinonic metabolites of benzene cause CYP destruction with different potency (30% CYP was destroyed by 3 mM catechol, 0.3 mM hydroquinone and 0.03 mM benzoquinone). catechol 112-120 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 42-45 8031317-5 1994 (2) Quinonic metabolites of benzene cause CYP destruction with different potency (30% CYP was destroyed by 3 mM catechol, 0.3 mM hydroquinone and 0.03 mM benzoquinone). catechol 112-120 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 86-89 8127373-3 1994 COMT also inactivates catechol-type compounds such as L-DOPA. catechol 22-30 catechol-O-methyltransferase Homo sapiens 0-4 8035323-1 1994 Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catecholamine and catechol drugs such as levodopa and methyldopa. catechol 67-75 catechol-O-methyltransferase Homo sapiens 0-28 8035323-1 1994 Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of catecholamine and catechol drugs such as levodopa and methyldopa. catechol 67-75 catechol-O-methyltransferase Homo sapiens 30-34 8113819-11 1994 Thus, the dopamine transporter requires an intact catechol with a primary ethylamine side chain for optimal activity relative to shorter side chain derivatives (side chains longer than two carbons were not tested), the 3-hydroxyl group of dopamine is the more critical hydroxyl group, and the beta rotamer of the extended conformation of dopamine is transported preferentially. catechol 50-58 solute carrier family 6 member 3 Homo sapiens 10-30 8019435-3 1994 In the present study, we examined the effects of catechol derivatives, nitecapone and OR-1246, which have been identified to possess potent antioxidant properties, on NF-kappa B activation by monitoring its DNA binding activity. catechol 49-57 nuclear factor kappa B subunit 1 Homo sapiens 167-177 8019435-8 1994 Hence, catechol derivatives inhibit NF-kappa B transcription factor through multiple mechanisms, and nitecapone and OR-1246 may be useful as therapeutic agents targeting NF-kappa B. catechol 7-15 nuclear factor kappa B subunit 1 Homo sapiens 36-46 8019435-8 1994 Hence, catechol derivatives inhibit NF-kappa B transcription factor through multiple mechanisms, and nitecapone and OR-1246 may be useful as therapeutic agents targeting NF-kappa B. catechol 7-15 nuclear factor kappa B subunit 1 Homo sapiens 170-180 8114683-3 1994 Using a panel of prototypical substrates and inhibitors for specific cytochromes P450, we identified substrates for CYP3A4 (midazolam, erythromycin, cyclosporin, and dexamethasone) as inhibitors of catechol formation from both etoposide and teniposide. catechol 198-206 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 116-122 8114683-10 1994 We conclude that catechol formation from teniposide and etoposide is primarily mediated by human CYP3A4, making these reactions susceptible to inhibition by prototypical 3A substrates and inhibitors. catechol 17-25 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 97-103 8109732-0 1993 Spectrophotometric assay of superoxide dismutase activity based on the activated autoxidation of a tetracyclic catechol. catechol 111-119 superoxide dismutase 1 Homo sapiens 28-48 18965828-2 1993 The proposed method was applied to the determination of catechol-resorcinol mixtures by oxidation with hydrogen peroxide in the presence of the enzyme peroxidase (EC 1. catechol 56-64 Susceptibility to lysis by alloreactive natural killer cells Homo sapiens 163-167 8352753-1 1993 The Michaelis constant of tyrosinase for oxygen in the presence of monophenols and o-diphenols, which generate a cyclizable o-quinone, has been studied. catechol 83-94 tyrosinase Homo sapiens 26-36 7518088-10 1993 In TMV-infected or elicitor-treated tissues, a marked increase in catechol-methylating activity accompanied the accumulation of class II OMT gene products. catechol 66-74 caffeic acid 3-O-methyltransferase-like Nicotiana tabacum 137-140 8403220-5 1993 Adducts of 1,2-BQ with human Alb were formed by activation of catechol (0-300 microM) in situ with horseradish peroxidase. catechol 62-70 albumin Homo sapiens 29-32 8344270-5 1993 Addition of 4-methylcatechol to m-toluate-grown wild-type and xylT cells resulted in the inactivation of catechol 2,3-dioxygenase in these cells. catechol 20-28 ferredoxin Pseudomonas putida 62-66 8344270-6 1993 In the wild-type strain but not in the xylT mutant, the catechol 2,3-dioxygenase activity was regenerated in a short time. catechol 56-64 ferredoxin Pseudomonas putida 39-43 8330359-0 1993 DNA methylation of the pepsinogen 1 gene during rat glandular stomach carcinogenesis induced by N-methyl-N"-nitro-N-nitrosoguanidine or catechol. catechol 136-144 progastricsin Rattus norvegicus 23-35 8330359-1 1993 The methylation patterns of the rat pepsinogen 1 (Pg1) gene in preneoplastic and neoplastic stomach lesions induced by genotoxic N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) or the non-genotoxic carcinogen catechol were investigated. catechol 205-213 progastricsin Rattus norvegicus 36-48 8330359-8 1993 In the mucosa containing PAPG in groups treated with MNNG or catechol the methylation patterns of the Pg1 gene were quite similar to those of normal pyloric mucosa, although the CCGG sites tended to demonstrate slightly increased methylation. catechol 61-69 progastricsin Rattus norvegicus 102-105 8466648-1 1993 The enzyme catechol-O-methyltransferase (COMT) catalyzes the inactivation of catechol-containing molecules by methylation. catechol 11-19 catechol-O-methyltransferase Rattus norvegicus 41-45 8333043-7 1993 The activity of hepatic COMT (substrate: catechol [5 mM] was not affected by transplantation or denervation. catechol 41-49 catechol-O-methyltransferase Rattus norvegicus 24-28 7682724-8 1993 The monoamine oxidase (MAO) inhibitors pargyline, i.p., and deprenyl, i.p., as well as the DA agonist apomorphine, i.p., decreased the catechol signal. catechol 135-143 monoamine oxidase A Rattus norvegicus 4-21 7682724-8 1993 The monoamine oxidase (MAO) inhibitors pargyline, i.p., and deprenyl, i.p., as well as the DA agonist apomorphine, i.p., decreased the catechol signal. catechol 135-143 monoamine oxidase A Rattus norvegicus 23-26 8081722-4 1993 In the first model, the beta-adrenergic receptor is used as a reference with the catechol moieties of dopamine interacting with two Ser residues in TM5, and the Asp residue in TM3 interacting with the protonated nitrogen of dopamine. catechol 81-89 tropomyosin 3 Homo sapiens 148-151 1284165-2 1992 It was initially used for resolution of the dopamine and dihydroxyphenylacetic acid components of the catechol signal (peak 2). catechol 102-110 PEAK1 related, kinase-activating pseudokinase 1 Homo sapiens 119-125 1447137-6 1992 Furthermore, the siderophore activity of this extracellular catechol was confirmed by its ability to stimulate energy-dependent uptake of 55Fe(III) as well as to promote the growth of A. baumannii bacterial cells under iron-deficient conditions imposed by 60 microM human transferrin. catechol 60-68 transferrin Homo sapiens 272-283 1325535-0 1992 Borate and molybdate inhibition of catechol estrogen and pyrocatechol methylation by catechol-O-methyltransferase. catechol 35-43 catechol-O-methyltransferase Rattus norvegicus 85-113 1325535-6 1992 Erythrocytes contain appreciable amounts of COMT, which is mostly responsible for the rapid O-methylation of catechol estrogens in blood. catechol 109-117 catechol-O-methyltransferase Rattus norvegicus 44-48 1618695-4 1992 The numbers and areas of GST-P-positive foci were significantly decreased by single treatment with butylated hydroxyanisole (BHA, 1%), tert-butylhydroquinone (TBHQ, 1%) and catechol (0.8%), but not with sesamol (0.5%). catechol 173-181 glutathione S-transferase pi 1 Rattus norvegicus 25-30 1469689-4 1992 The assayed compounds showed a reversible inhibition of COMT, which was mixed for all the dihydroxynitro derivatives but noncompetitive for 3-hydroxy-4-methoxy-5-nitrobenzaldehyde when pyrocatechol was the variable substrate and uncompetitive in all the inhibitors with respect to S-adenosyl-L-methionine. catechol 185-197 catechol-O-methyltransferase Sus scrofa 56-60 1449530-11 1992 C-4 oxygenation of 2-FEE2, resulting in catechol formation, occurred but to a lesser extent (ca. catechol 40-48 complement C4A Rattus norvegicus 0-3 1435745-3 1992 Formation of catechol and sesamol from MDB in microsomal incubation mixtures was enhanced about 5- and 3-fold, respectively, by pretreatment of the rabbits with phenobarbital, which induced CYP2B4 and CYP4B1. catechol 13-21 cytochrome P450 2B4 Oryctolagus cuniculus 190-196 1435745-3 1992 Formation of catechol and sesamol from MDB in microsomal incubation mixtures was enhanced about 5- and 3-fold, respectively, by pretreatment of the rabbits with phenobarbital, which induced CYP2B4 and CYP4B1. catechol 13-21 cytochrome P450 4B1 Oryctolagus cuniculus 201-207 1460376-0 1992 Effects of catechol compound administration on nerve growth factor synthesis in the peripheral nervous system. catechol 11-19 nerve growth factor Rattus norvegicus 47-66 1460376-1 1992 The effects of the intraperitoneal administration of catechol compounds on nerve growth factor (NGF) synthesis in the peripheral nervous system were examined in Wistar male rats. catechol 53-61 nerve growth factor Rattus norvegicus 75-94 1460376-1 1992 The effects of the intraperitoneal administration of catechol compounds on nerve growth factor (NGF) synthesis in the peripheral nervous system were examined in Wistar male rats. catechol 53-61 nerve growth factor Rattus norvegicus 96-99 1460376-7 1992 Therefore, catechol compounds stimulate NGF synthesis in the peripheral nervous system, and NGF induced by 4-MC is transported retrogradely in the axon to the soma in a physiological manner. catechol 11-19 nerve growth factor Rattus norvegicus 40-43 1460376-8 1992 Furthermore, in the dorsal root ganglion and superior cervical ganglion, the use of substance P and tyrosine hydroxylase activity as biochemical markers of sensory and sympathetic neurons has demonstrated the biological activity of newly-synthesized NGF induced by catechol compounds. catechol 265-273 nerve growth factor Rattus norvegicus 250-253 1560233-6 1992 Km values were 10 microM for MB-COMT and 108 microM for S-COMT, indicating that recombinant MB-COMT exhibits a higher affinity for catechol as the substrate than the soluble form. catechol 131-139 catechol-O-methyltransferase Homo sapiens 32-36 1560233-6 1992 Km values were 10 microM for MB-COMT and 108 microM for S-COMT, indicating that recombinant MB-COMT exhibits a higher affinity for catechol as the substrate than the soluble form. catechol 131-139 catechol-O-methyltransferase Homo sapiens 58-62 1560233-6 1992 Km values were 10 microM for MB-COMT and 108 microM for S-COMT, indicating that recombinant MB-COMT exhibits a higher affinity for catechol as the substrate than the soluble form. catechol 131-139 catechol-O-methyltransferase Homo sapiens 58-62 1388592-1 1992 The influence of bioisosteric replacement of catechol moiety of L-Dopa and alpha-Methyldopa with benzimidazole and benzotriazole ring has been examined on dopamine beta-hydroxylase and tyrosinase, in order to evidentiate an inhibitory activity on the synthesis of catecholamines and a possible antihypertensive action. catechol 45-53 dopamine beta-hydroxylase Homo sapiens 155-180 1388592-1 1992 The influence of bioisosteric replacement of catechol moiety of L-Dopa and alpha-Methyldopa with benzimidazole and benzotriazole ring has been examined on dopamine beta-hydroxylase and tyrosinase, in order to evidentiate an inhibitory activity on the synthesis of catecholamines and a possible antihypertensive action. catechol 45-53 tyrosinase Homo sapiens 185-195 1572656-1 1992 Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is a physiologically important enzyme in the metabolism of catecholamine neurotransmitters and catechol drugs. catechol 107-115 catechol-O-methyltransferase Homo sapiens 0-28 1572656-1 1992 Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is a physiologically important enzyme in the metabolism of catecholamine neurotransmitters and catechol drugs. catechol 107-115 catechol-O-methyltransferase Homo sapiens 30-34 1325535-0 1992 Borate and molybdate inhibition of catechol estrogen and pyrocatechol methylation by catechol-O-methyltransferase. catechol 57-69 catechol-O-methyltransferase Rattus norvegicus 85-113 1600191-2 1992 The cuticle-bound phenoloxidase from the white puparium exhibited a pH optimum of 6.5 in phosphate buffer and oxidized a variety of catecholic substrates such as 4-methylcatechol, N-beta-alanyldopamine, dopa, dopamine, N-acetyldopamine, catechol, norepinephrine, 3,4-dihydroxyphenylglycol, 3,4-dihydroxybenzoic acid, and 3,4-dihydroxyphenylacetic acid. catechol 132-140 Phox Drosophila melanogaster 18-31 1993181-11 1991 A small DNA segment (831 base pairs) disrupts the continuity of the known gene order nahG and nahH, the latter encoding catechol 2,3-dioxygenase. catechol 120-128 salicylate hydroxylase Pseudomonas putida 85-89 1655979-0 1991 Interactions between the argininyl moieties of neurotensin and the catechol protons of dopamine. catechol 67-75 neurotensin Homo sapiens 47-58 1655979-6 1991 The results of studies of the formal potential of dopamine in the presence of Arg and Arg-containing peptides confirmed that catechol protons are directly involved in the association and that the chemical species of dopamine associated with neurotensin is a catecholate form. catechol 125-133 neurotensin Homo sapiens 241-252 1777927-0 1991 Quantitative structure-activity relationship of catechol derivatives inhibiting 5-lipoxygenase. catechol 48-56 arachidonate 5-lipoxygenase Homo sapiens 80-94 1777927-1 1991 Various catechol derivatives (beta-substituted 3,4-dihydroxystyrenes, 1-substituted 3,4-dihydroxybenzenes, and 6-substituted 2,3-dihydroxynaphthalenes) were synthesized and their inhibition of 5-lipoxygenase was assayed. catechol 8-16 arachidonate 5-lipoxygenase Homo sapiens 193-207 1654782-4 1991 In order to gain insights into the mechanisms of this stimulation, we have compared the kinetics of human myeloperoxidase-dependent phenol, hydroquinone, and catechol metabolism. catechol 158-166 myeloperoxidase Homo sapiens 106-121 1654782-5 1991 The specificity (Vmax/Km) of hydroquinone for myeloperoxidase was found to be 5-fold greater than that of catechol and 16-fold greater than that of phenol. catechol 106-114 myeloperoxidase Homo sapiens 46-61 1654782-6 1991 These specificities for myeloperoxidase-dependent metabolism inversely correlated with the respective one-electron oxidation potentials of hydroquinone, catechol, and phenol and suggested that phenol- and catechol-induced stimulation of myeloperoxidase-dependent hydroquinone metabolism cannot simply be explained by interaction of hydroquinone with stimulant-derived radicals. catechol 153-161 myeloperoxidase Homo sapiens 24-39 1654782-6 1991 These specificities for myeloperoxidase-dependent metabolism inversely correlated with the respective one-electron oxidation potentials of hydroquinone, catechol, and phenol and suggested that phenol- and catechol-induced stimulation of myeloperoxidase-dependent hydroquinone metabolism cannot simply be explained by interaction of hydroquinone with stimulant-derived radicals. catechol 153-161 myeloperoxidase Homo sapiens 237-252 1654782-6 1991 These specificities for myeloperoxidase-dependent metabolism inversely correlated with the respective one-electron oxidation potentials of hydroquinone, catechol, and phenol and suggested that phenol- and catechol-induced stimulation of myeloperoxidase-dependent hydroquinone metabolism cannot simply be explained by interaction of hydroquinone with stimulant-derived radicals. catechol 205-213 myeloperoxidase Homo sapiens 24-39 1654782-6 1991 These specificities for myeloperoxidase-dependent metabolism inversely correlated with the respective one-electron oxidation potentials of hydroquinone, catechol, and phenol and suggested that phenol- and catechol-induced stimulation of myeloperoxidase-dependent hydroquinone metabolism cannot simply be explained by interaction of hydroquinone with stimulant-derived radicals. catechol 205-213 myeloperoxidase Homo sapiens 237-252 1654782-7 1991 Phenol (100 microM), catechol (20 microM), and imidazole (50 mM) did, however, all increase the specificity (Vmax/Km) of hydroquinone for myeloperoxidase, indicating that these three compounds may be stimulating hydroquinone metabolism by a common mechanism. catechol 21-29 myeloperoxidase Homo sapiens 138-153 1917904-1 1991 Salicylate hydroxylase [EC 1.14.13.1] from Pseudomonas putida catalyzes the hydroxylation of salicylate, and also o-aminophenol, o-nitrophenol, and o-halogenophenols, to catechol. catechol 170-178 salicylate hydroxylase Pseudomonas putida 0-22 1997095-5 1991 As a possible mechanism that might account for this action, it may be that 4-S-CAP is oxidised by tyrosinase to the o-quinone form via the catechol derivative and that some of the quinones then conjugate with sulfhydryl enzymes including DNA polymerase, thus exerting a killing activity for pigmented melanoma cells. catechol 139-147 tyrosinase Mus musculus 98-108 1648866-0 1991 Effect of phenol and catechol on the kinetics of human myeloperoxidase-dependent hydroquinone metabolism. catechol 21-29 myeloperoxidase Homo sapiens 55-70 1864847-1 1991 Salicylate hydroxylase [EC 1.14.13.1] from Pseudomonas putida catalyzed the formation of catechol from substrate analogues such as o-nitro-, o-amino-, o-iodo-, o-bromo-, and o-chloro-phenol by removing the ortho-substituted groups. catechol 89-97 salicylate hydroxylase Pseudomonas putida 0-22 2002245-5 1991 Colonies of cells which express the xylE gene turn yellow shortly after being exposed with a solution of catechol. catechol 105-113 catechol 2,3-dioxygenase Pseudomonas putida 36-40 1974641-10 1990 These results indicate that MDMA is oxidized by cytochrome P-450 to the catechol and the catecholamine oxidized by superoxide to a quinone to which GSH or other thiol functions add. catechol 72-80 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 48-64 2245407-3 1990 The compounds that demonstrated inhibition also induced GST-P in the hepatic periportal areas, suggesting that development of GST-P positive foci is negatively influenced by extra-focal increase in this enzyme form observed with BHA, BHT or catechol. catechol 241-249 glutathione S-transferase pi 1 Rattus norvegicus 126-131 2223838-1 1990 Salicylate hydroxylase from Pseudomonas putida (EC 1.14.13.1, salicylate, NADH:oxygen oxidoreductase) is an FAD-containing monooxygenase, which catalyzes decarboxylative hydroxylation of salicylate to produce catechol in the presence of NADH and O2. catechol 209-217 salicylate hydroxylase Pseudomonas putida 0-22 1651573-1 1991 The effects of two catechols (1,2-benzenediol and nordihydroguaiaretic acid) on the myeloperoxidase-Cl(-)-H2O2 antimicrobial/cytotoxic system of the human neutrophil were investigated. catechol 30-45 myeloperoxidase Homo sapiens 84-99 1366935-2 1990 Since, xyl E gene (which encodes catechol 2,3-dioxygenase from Pseudomonas putida) transcription is controlled by the trp promoter, the effects of tryptophan (repressor) and 3 beta-indolyl acrylic acid (derepressor) on pTG 205 stability and enzyme production have been studied in both free and immobilized cell cultures. catechol 33-41 catechol 2,3-dioxygenase Pseudomonas putida 7-12 25989628-3 1990 The major pathway of metabolism I involved cytochrome P-450-mediated cleavage of the methylenedioxy ring to yield catechol derivatives. catechol 114-122 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 43-59 2307236-2 1990 We wished to further assess the structural properties required for exhibition of such effect of compounds containing a ring structure analogous to that of catechol on astroglial NGF synthesis. catechol 155-163 nerve growth factor Mus musculus 178-181 2358408-0 1990 Structure-activity relationships of some arylglycine analogues and catechol isosteres of BRL 36650, a 6 alpha-formamido penicillin. catechol 67-75 bromodomain containing 1 Homo sapiens 89-92 1970632-7 1990 Tertiary butyl substitution on the amino nitrogen gave the highest beta 2-adrenoceptor selectivity in both the catechol and resorcinol series. catechol 111-119 beta-2 adrenergic receptor Cavia porcellus 67-86 34939797-4 2022 Catechol siderophore-like compounds are known to bind siderocalin (Scn)/lipocalin-2 to form stable siderophore:Fe:Scn complexes. catechol 0-8 lipocalin 2 Homo sapiens 72-83 2114224-2 1990 Both the formation of hydrogen peroxide and that of 8-OHdG in DNA was significantly decreased when catalase or tyrosinase was added to the smoke condensates, and this also occurred when pure hydroquinone or catechol, two major constitutes in cigarette smoke, was used instead of smoke condensate. catechol 207-215 catalase Homo sapiens 99-107 2114224-2 1990 Both the formation of hydrogen peroxide and that of 8-OHdG in DNA was significantly decreased when catalase or tyrosinase was added to the smoke condensates, and this also occurred when pure hydroquinone or catechol, two major constitutes in cigarette smoke, was used instead of smoke condensate. catechol 207-215 tyrosinase Homo sapiens 111-121 2131828-8 1990 Furthermore, the tris-OH-M becomes radiolabeled by [methyl-3H3]-S- adenosylmethionine (SAM) in a reaction catalyzed by catechol O-methyltransferase (COMT), indicating that tris-OH-M behaves like a catechol. catechol 119-127 catechol-O-methyltransferase Rattus norvegicus 149-153 34882422-5 2022 The initial step involves a stoichiometric reaction between the substrate and TAP-1, which leads to the in situ generation of the catalyst, a catechol cyclic phosphate, as well as to a pyrocatechol phosphate and two possible active intermediates. catechol 142-150 transporter 1, ATP binding cassette subfamily B member Homo sapiens 78-83 34571130-5 2021 Here, catechol groups modified epsilon-polylysine (PL-CAT) and polyacrylamide (PAAM) were used to construct the PL-CAT/PAAM hydrogel. catechol 6-14 catalase Homo sapiens 115-118 34969954-6 2021 Particularly, metal chelation via catechol group linked with the free 3-OH group on the unconjugated dihydropyran heterocycle chain was elucidated to contribute to tyrosinase inhibition by (-/+)-catechin against cyanidin-3-O-glucoside. catechol 34-42 tyrosinase Mus musculus 164-174 34718823-10 2021 In vitro, the benzene metabolites, hydroquinone and catechol, induced the expression of P-selectin in cardiac microvascular endothelial cells by 5-fold and increased the adhesion of neutrophils to these endothelial cells by 1.5-2.0-fold. catechol 52-60 selectin, platelet Mus musculus 88-98 34813317-4 2021 When catechol is sequentially oxidized by O3 and NO3 in the presence of (NH4)2SO4 seed particles with a single size mode, we observe a bimodal organic aerosol mass size distribution with two size modes of distinct chemical composition with nitrocatechol from NO3 oxidation preferentially condensing onto the large end of the pre-existing size distribution (~750 nm). catechol 5-13 NBL1, DAN family BMP antagonist Homo sapiens 49-52 34813317-4 2021 When catechol is sequentially oxidized by O3 and NO3 in the presence of (NH4)2SO4 seed particles with a single size mode, we observe a bimodal organic aerosol mass size distribution with two size modes of distinct chemical composition with nitrocatechol from NO3 oxidation preferentially condensing onto the large end of the pre-existing size distribution (~750 nm). catechol 5-13 NBL1, DAN family BMP antagonist Homo sapiens 259-262 34571130-5 2021 Here, catechol groups modified epsilon-polylysine (PL-CAT) and polyacrylamide (PAAM) were used to construct the PL-CAT/PAAM hydrogel. catechol 6-14 catalase Homo sapiens 54-57 34681535-7 2021 AA only slows mechanism-based inactivation of PPO induced by catechol, possibly owing to the prevention of quinone formation. catechol 61-69 catechol oxidase B, chloroplastic Solanum tuberosum 46-49 34832900-7 2021 The results showed that catechol-containing compounds 1-6 exhibited Abeta/hIAPP anti-aggregation and disaggregation activities, while compound 7, without catechol, showed no activity. catechol 24-32 amyloid beta precursor protein Homo sapiens 68-73 34832900-7 2021 The results showed that catechol-containing compounds 1-6 exhibited Abeta/hIAPP anti-aggregation and disaggregation activities, while compound 7, without catechol, showed no activity. catechol 24-32 islet amyloid polypeptide Homo sapiens 74-79 34681535-9 2021 The problem associated with AA in PPO assay could be circumvented by using ascorbate oxidase to remove AA when catechol is the primary substrate or by using chlorogenic acid as the primary substrate. catechol 111-119 catechol oxidase B, chloroplastic Solanum tuberosum 34-37 34520185-9 2021 The reaction of the Cu(I) complex (Cu(LH2))+ with a variety of monodentate ligands X (PPh3, Cl-, SCN-, CN-) released the metal from coordination to the imine, thereby restoring imine H-bonding with the catechol proton. catechol 202-210 protein phosphatase 4 catalytic subunit Homo sapiens 86-90 34520185-10 2021 The second catechol proton engages in H-bonding with Cu-X (X = Cl, CN, SCN), which can be intermolecular (XRD) or intramolecular (DFT). catechol 11-19 cut like homeobox 1 Homo sapiens 53-57 34587154-1 2021 Catechol-estrogens can cause genetic mutations and to counteract their oncogenicity, the catechol-O-methyltransferase (COMT) gene is capable of neutralizing these reactive compounds. catechol 0-8 catechol-O-methyltransferase Homo sapiens 89-117 34243013-7 2021 CYP3A4 and CYP3A5 metabolize etoposide to etoposide catechol, which readily oxidizes to etoposide quinone. catechol 52-60 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 34243013-7 2021 CYP3A4 and CYP3A5 metabolize etoposide to etoposide catechol, which readily oxidizes to etoposide quinone. catechol 52-60 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 11-17 34587154-1 2021 Catechol-estrogens can cause genetic mutations and to counteract their oncogenicity, the catechol-O-methyltransferase (COMT) gene is capable of neutralizing these reactive compounds. catechol 0-8 catechol-O-methyltransferase Homo sapiens 119-123 34683865-6 2021 We demonstrated the existence of quetiapine derivatives with a catechol-like structure (7,8-dihydroxi-quetiapine and 7,8-dihydroxi-N-desalkyl-quetiapine), which would be COMT metabolites and would explain quetiapine accumulation through CYP2D6 and CYP3A4 negative feedback. catechol 63-71 catechol-O-methyltransferase Homo sapiens 170-174 34683865-6 2021 We demonstrated the existence of quetiapine derivatives with a catechol-like structure (7,8-dihydroxi-quetiapine and 7,8-dihydroxi-N-desalkyl-quetiapine), which would be COMT metabolites and would explain quetiapine accumulation through CYP2D6 and CYP3A4 negative feedback. catechol 63-71 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 237-243 34683865-6 2021 We demonstrated the existence of quetiapine derivatives with a catechol-like structure (7,8-dihydroxi-quetiapine and 7,8-dihydroxi-N-desalkyl-quetiapine), which would be COMT metabolites and would explain quetiapine accumulation through CYP2D6 and CYP3A4 negative feedback. catechol 63-71 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 248-254 34405997-4 2021 Through the addition of an adequate oxidant and catalase, the catechol-conjugated alginate (C-ALG) hydrogel showed rapid gelation for less than 5 min, similar mechanical properties to lung tissue, slight swelling degree, good cell compatibility, and enough tissue adhesion for localization around the lung tissue. catechol 62-70 catalase Homo sapiens 48-56 34137422-0 2021 Catechol-driven self-assembly to fabricate highly ordered and SERS-active glycoadjuvant patterns. catechol 0-8 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 62-66 34293859-7 2021 The reaction is similar to a "zipping up" process to construct covalent bonds in the I-II interface and layer I by coupling adjacent catechol groups, which facilely achieved grafting and cross-linking. catechol 133-141 uridine phosphorylase 1 Homo sapiens 38-41 34098397-3 2021 Additional TEM experiment confirmed that ortho-catechol containing isoflavone 4d significantly prevented the aggregation of both Abeta and tau. catechol 47-55 amyloid beta (A4) precursor protein Mus musculus 129-134 34423269-5 2021 Further screening of a targeted library of natural compounds in complementary medicine that were enriched with catechol-containing compounds identified rosmarinic acid (RA) as a potent inhibitor of amylin aggregation (estimated inhibitory concentration IC50 = 200-300 nM). catechol 111-119 islet amyloid polypeptide Homo sapiens 198-204 34264188-9 2022 CONCLUSION: Catechol derivatives are successful zinc chelators in the Glo-I enzyme while showing exceptional activity against the enzyme to the nanomolar level. catechol 12-20 glyoxalase I Homo sapiens 70-75 34347312-2 2021 The presence of catechol moiety in dopamine was exploited to form pH-responsive cross-links with ferric ions (Fe3+ ) at different pH value. catechol 16-24 phenylalanine hydroxylase Homo sapiens 66-68 34347312-2 2021 The presence of catechol moiety in dopamine was exploited to form pH-responsive cross-links with ferric ions (Fe3+ ) at different pH value. catechol 16-24 phenylalanine hydroxylase Homo sapiens 130-132 34469614-2 2021 Herein, a long polypeptide chain derived from the abundant serum protein human serum albumin was cross-linked by dynamic-coordinative iron(III)/catechol bonds. catechol 144-152 albumin Homo sapiens 79-92 34137422-4 2021 More importantly, highly ordered glycoadjuvant patterns could be easily formed by catechol-driven self-assembly under confinement, which exhibit a higher SERS signal amplification ability for the detection of carbohydrates (glycoadjuvant). catechol 82-90 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 154-158 34083522-0 2021 Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist. catechol 78-86 dopamine receptor D1 Homo sapiens 21-41 34194436-6 2021 Our results indicate that RIG-I agonists required full length-MAVS whereas the AOS response induced by Dynasore through its catechol group can reactivate latent HIV-1 in a MAVS dependent manner through miniMAVS isoform. catechol 124-132 mitochondrial antiviral signaling protein Homo sapiens 172-176 34121987-7 2021 Several gut bacterial metabolic pathways were significantly altered in fmr1 KO2 mice, including menaquinone degradation, catechol degradation, vitamin B6 biosynthesis, fatty acid biosynthesis, and nucleotide metabolism. catechol 121-129 fragile X messenger ribonucleoprotein 1 Mus musculus 71-75 34095664-0 2021 Natural Molybdenite- and Tyrosinase-Based Amperometric Catechol Biosensor Using Acridine Orange as a Glue, Anchor, and Stabilizer for the Adsorbed Tyrosinase. catechol 55-63 tyrosinase Homo sapiens 25-35 34095664-0 2021 Natural Molybdenite- and Tyrosinase-Based Amperometric Catechol Biosensor Using Acridine Orange as a Glue, Anchor, and Stabilizer for the Adsorbed Tyrosinase. catechol 55-63 tyrosinase Homo sapiens 147-157 34095664-2 2021 The developed TYR/AO/MLN-GCE-based amperometric TYR biosensor exhibited excellent performance for highly sensitive determination of catechol (linear range, 0.1-80 muM; sensitivity, 0.0315 muA/muM; LOD, 0.029 muM; response time, <4 s) with good reproducibility and good operational and storage stabilities. catechol 132-140 tyrosinase Homo sapiens 14-17 34095664-2 2021 The developed TYR/AO/MLN-GCE-based amperometric TYR biosensor exhibited excellent performance for highly sensitive determination of catechol (linear range, 0.1-80 muM; sensitivity, 0.0315 muA/muM; LOD, 0.029 muM; response time, <4 s) with good reproducibility and good operational and storage stabilities. catechol 132-140 tyrosinase Homo sapiens 48-51 35416384-4 2022 The proposed method exhibited good liearnity for the detection of catechol in the range of 0.50-8.00 mug mL-1 . catechol 66-74 L1 cell adhesion molecule Mus musculus 105-109 35595358-0 2022 A two-dimensional G-CoP/N,P-co-doped carbon nanowire electrode for the simultaneous determination of hydroquinone and catechol in domestic wastewater. catechol 118-126 caspase recruitment domain family member 16 Homo sapiens 20-23 35611945-1 2022 Herein, a graphene-nano-molybdenum disulphide (pGr-MoS2), synthesized from pulverized graphite and using precursors of MoS2, was investigated for the electrochemical sensing of dihydroxy benzene isomers (DHBI): hydroquinone (HQ), catechol (CA), and resorcinol (RE). catechol 230-238 progesterone receptor Homo sapiens 47-50 34821330-10 2021 It is supposed that the synergistic interactions of the adhesive catechol group, displacement of water on the wet skin surface by the positively charged -NH3+ groups of CS and the water-repelling potential of the hydrophobic unit of the catechol derivative, the protection of the catechol group from oxidation into a less adhesive quinone group, and the energy dissipation capacity of the mechanically tough hydrogel contribute to the strong and repeatable wet tissue adhesion. catechol 65-73 citrate synthase Homo sapiens 169-171 35597283-0 2022 SifR is an Rrf2-family quinone sensor associated with catechol iron uptake in Streptococcus pneumoniae D39. catechol 54-62 GTP dependent ribosome recycling factor mitochondrial 2 Homo sapiens 11-15 35212189-3 2022 The aniline para substituent and catechol within the amidoboronates tuned the rac5 /rac6 ratio; the rac6 isomer predominated for amidoboronates based on pyrocatechol, ranging from a ratio of 0 : 1 with electron-withdrawing Cl substituents to 0.5 : 0.5 for electron-donating NMe2 substituents. catechol 33-41 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 274-278 35283192-5 2022 Moreover, we show that the acquisition of catechol siderophores and catecholamine stress hormones by S. lugdunensis required the presence of the sst-1 transporter-encoding locus, but not the sst-2 locus. catechol 42-50 susceptibility to tuberculosis 1 Mus musculus 145-150 35332614-2 2022 In contrast to catechol derivatives, which are generally susceptible to oxidation by air under ambient conditions, the monophenol-based TBAD remains stable under alkaline and neutral conditions, and is activated to oxidized quinone in situ by tyrosinase to initiate melanin-like polymerization. catechol 15-23 tyrosinase Homo sapiens 243-253 35413192-7 2022 The proposed catechol sensor shows a wide dynamic range (0.007-200 muM) with a lower level of detection (2.3 nm) and sensitivity (3.57 muA muM-1 cm-2). catechol 13-21 PWWP domain containing 3A, DNA repair factor Homo sapiens 139-144 34099595-2 2022 However, when administrated in vivo, luteolin will be methylated by Catechol-O-methyltransferases (COMT) owing to the catechol ring in the chemical structure, which will largely diminish its anti-inflammatory effect. catechol 118-126 catechol-O-methyltransferase Homo sapiens 68-97 34099595-2 2022 However, when administrated in vivo, luteolin will be methylated by Catechol-O-methyltransferases (COMT) owing to the catechol ring in the chemical structure, which will largely diminish its anti-inflammatory effect. catechol 118-126 catechol-O-methyltransferase Homo sapiens 99-103 2597177-1 1989 The inhibition kinetics of rat liver and duodenum soluble catechol-O-methyltransferase (COMT) with a disubstituted catechol OR-462 was studied. catechol 58-66 catechol-O-methyltransferase Rattus norvegicus 88-92 35574260-7 2022 Then, the same NGAL but bound with the iron-catechol complexes through the cation-pi interactions as a holo-form was characterized. catechol 44-52 lipocalin 2 Homo sapiens 15-19 2514167-2 1989 Administration of catechol by gastric intubation at doses of 10 to 90 mg/kg body weight to male F344 rats induced up to 19-fold increase in ornithine decarboxylase activity with a maximum after 8 h and up to 8-fold increase in replicative DNA synthesis with a maximum after 24 h in the pyloric mucosa of the stomach. catechol 18-26 ornithine decarboxylase 1 Rattus norvegicus 140-163 2557901-5 1989 Incubation of soybean lipoxygenase and linoleic acid with p-aminophenol, catechol, hydroquinone, NDGA, or phenidone resulted in the formation of the one-electron oxidation products of these compounds. catechol 73-81 linoleate 9S-lipoxygenase-4 Glycine max 22-34 2811369-7 1989 Finally, a method utilized to measure estrogen 2-hydroxylase activity in vitro is a radioenzymatic assay involving addition of catechol o-methyltransferase (COMT) and radiolabeled S-adenosylmethionine, and the amount of catechol estrogens formed is determined by the amount of radiolabeled methoxyestrogens isolated. catechol 127-135 catechol-O-methyltransferase Rattus norvegicus 157-161 2910532-1 1989 Catechol-O-methyltransferase (COMT) [EC 2.1.1.6] is a ubiquitous cytosolic enzyme which has a pertinent role in the inactivation of both natural and synthetic catechol estrogens in mammalian tissues. catechol 159-167 catechol-O-methyltransferase Homo sapiens 0-28 2508631-4 1989 This approach is illustrated by a study of the suicide inactivation of tyrosinase by catechol in the presence of L-proline. catechol 85-93 tyrosinase Homo sapiens 71-81 2555817-1 1989 The role of catechol-o-methyltransferase (COMT) in functional interrelationship between testosterone (T), catechol estrogens (CE) and catecholamines (CA) during cerebral sex differentiation (CSD) was investigated in experiments on Wistar rats. catechol 12-20 catechol-O-methyltransferase Rattus norvegicus 42-46 2548593-3 1989 Autoxidation of the catechol yields the primary semiquinone together with the primary molecular product VP-16 quinone, which subsequently undergoes hydrolytic oxidation to form secondary quinones and semiquinones. catechol 20-28 host cell factor C1 Homo sapiens 104-109 2568905-1 1989 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catecholamines and phenolic and catechol drugs. catechol 67-75 sulfotransferase family 1A member 1 Homo sapiens 0-23 2568905-1 1989 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catecholamines and phenolic and catechol drugs. catechol 67-75 sulfotransferase family 1A member 1 Homo sapiens 25-28 2473848-3 1989 On the other hand, although UV-irradiated bleomycin scarcely broke the DNA strand in the presence of 1,2-benzenediol (catechol), it stimulated the action of DNase I to degrade DNA in the presence of catechol. catechol 199-207 deoxyribonuclease 1 Homo sapiens 157-164 2910532-1 1989 Catechol-O-methyltransferase (COMT) [EC 2.1.1.6] is a ubiquitous cytosolic enzyme which has a pertinent role in the inactivation of both natural and synthetic catechol estrogens in mammalian tissues. catechol 159-167 catechol-O-methyltransferase Homo sapiens 30-34 2910532-7 1989 The significantly lower COMT activity in the hamster liver and red blood cells suggests that under chronic estrogen treatment at high doses, the concentration of catechol estrogens in these tissues may exceed the capacity of COMT to effectively catalyse their O-methylation into inactive metabolites. catechol 162-170 catechol-O-methyltransferase Mus musculus 24-28 2536446-2 1989 However, the actions of catechol estrogens on the hypothalamic control of the prolactin (PRL) release seem to be different to the effects caused by native estrogens. catechol 24-32 prolactin Rattus norvegicus 78-87 2536446-2 1989 However, the actions of catechol estrogens on the hypothalamic control of the prolactin (PRL) release seem to be different to the effects caused by native estrogens. catechol 24-32 prolactin Rattus norvegicus 89-92 2748687-4 1989 Mechanistic studies suggest that catechol affects BaP metabolism and especially secondary oxidation reactions of this carcinogen and thus changes the proportion of BPDE-DNA adducts. catechol 33-41 prohibitin 2 Mus musculus 50-53 2704029-1 1989 A series of disubstituted catechol derivatives was synthesized and tested as potential COMT inhibitors. catechol 26-34 catechol-O-methyltransferase Homo sapiens 87-91 2779948-3 1989 However, exposure of the cells to p-benzoquinone, hydroquinone or catechol, dihydroxy- and diketo-metabolites of benzene, resulted in a severe inhibition of interferon-alpha/beta production. catechol 66-74 interferon alpha Mus musculus 157-173 2848987-7 1988 The differential effect of these metal ions on estrogen metabolism gives additional support for two different mechanisms in the cytochrome P-450-catalyzed formation of catechol estrogens and their further activation to form protein conjugates. catechol 168-176 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 128-144 3146978-1 1988 Tyrosinase usually catalyses the conversion of monophenols into o-diphenols and the oxidation of diphenols to the corresponding o-quinones. catechol 64-75 tyrosinase Homo sapiens 0-10 2846069-1 1988 Tyrosinase usually catalyzes the conversion of monophenols to o-diphenols and the oxidation of o-diphenols to the corresponding quinones. catechol 62-73 tyrosinase Homo sapiens 0-10 2846069-1 1988 Tyrosinase usually catalyzes the conversion of monophenols to o-diphenols and the oxidation of o-diphenols to the corresponding quinones. catechol 95-106 tyrosinase Homo sapiens 0-10 3139626-2 1988 The catA, catB, and catC genes encode enzymes that catalyze consecutive reactions in the catechol branch of the beta-ketoadipate pathway: catA, catechol-1,2-dioxygenase (EC 1.13.11.1); catB, muconate lactonizing enzyme (EC 5.5.1.1); and catC, muconolactone isomerase (EC 5.3.3.4). catechol 89-97 catechol 1,2-dioxygenase Pseudomonas aeruginosa PAO1 4-8 2972290-6 1988 Reduction of the ortho-quinone by NADPH cytochrome P-450 reductase resulted in formation of the catechol. catechol 96-104 cytochrome p450 oxidoreductase Bos taurus 34-66 3139626-2 1988 The catA, catB, and catC genes encode enzymes that catalyze consecutive reactions in the catechol branch of the beta-ketoadipate pathway: catA, catechol-1,2-dioxygenase (EC 1.13.11.1); catB, muconate lactonizing enzyme (EC 5.5.1.1); and catC, muconolactone isomerase (EC 5.3.3.4). catechol 89-97 catechol 1,2-dioxygenase Pseudomonas aeruginosa PAO1 138-142 2448006-5 1987 The changes in catechol metabolic activity in response to hypovolemia were accompanied by similar trends of variations of plasma vasopressin levels. catechol 15-23 arginine vasopressin Rattus norvegicus 129-140 3181288-1 1988 Catechol-O-methyltransferase (COMT) has an important role in the extraneuronal inactivation of catecholamine neurotransmitters and drugs with a catechol structure. catechol 95-103 catechol-O-methyltransferase Rattus norvegicus 0-28 2898209-1 1988 Dose-response infusions (0.25 to 4.0 micrograms/kg/min) and extended infusions of dopexamine, a new synthetic catechol with beta 2 adrenergic and dopaminergic agonist effects, were performed in 12 patients with low output congestive heart failure (CHF). catechol 110-118 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 124-130 3181288-1 1988 Catechol-O-methyltransferase (COMT) has an important role in the extraneuronal inactivation of catecholamine neurotransmitters and drugs with a catechol structure. catechol 95-103 catechol-O-methyltransferase Rattus norvegicus 30-34 2835907-4 1988 In view of the present data and the importance of catechol estrogens in prostaglandin synthesis and in potentiating the activity of catecholamines through competitive inhibition of catechol-O-methyltransferase, it is suggested that catechol estrogens may play a role in triggering the events involved in the onset of labor and delivery in humans. catechol 50-58 catechol-O-methyltransferase Homo sapiens 181-209 2835907-4 1988 In view of the present data and the importance of catechol estrogens in prostaglandin synthesis and in potentiating the activity of catecholamines through competitive inhibition of catechol-O-methyltransferase, it is suggested that catechol estrogens may play a role in triggering the events involved in the onset of labor and delivery in humans. catechol 132-140 catechol-O-methyltransferase Homo sapiens 181-209 3042142-2 1988 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of many phenolic and catechol neurotransmitters. catechol 85-93 sulfotransferase family 1A member 1 Homo sapiens 0-23 3042142-2 1988 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of many phenolic and catechol neurotransmitters. catechol 85-93 sulfotransferase family 1A member 1 Homo sapiens 25-28 2964867-1 1987 The usual substrates of tyrosinase, a copper-containing monooxygenase (EC 1.14.18.1), are monophenols and o-diphenols which are both converted to o-quinones. catechol 106-117 tyrosinase Homo sapiens 24-34 2828490-6 1987 These data indicate that catechol estrogen interferes with the brief neuronal triggering phase necessary for LH-RH release, but does not affect the LH tonic secretion which is an estrogen-independent process. catechol 25-33 gonadotropin releasing hormone 1 Rattus norvegicus 109-114 3312486-1 1987 The effect of temperature on the stability of pTG201, a plasmid carrying the xylE gene (which encodes catechol 2,3-dioxygenase from Pseudomonas putida), and the production of catechol 2,3-dioxygenase in free and immobilized Escherichia coli during continuous culture have been studied at various temperatures. catechol 102-110 catechol 2,3-dioxygenase Pseudomonas putida 77-81 3112146-1 1987 Tyrosinase, which usually catalyzes the conversion of o-diphenols to o-benzoquinones, catalyzed an unusual oxidative dimerization of 1,2-dehydro-N-acetyl-dopamine to a benzodioxan derivative. catechol 54-65 tyrosinase Homo sapiens 0-10 3312486-3 1987 Since xylE transcription was controlled by the lambda PR promoter and cI857 repressor, increasing derepression temperatures increased catechol 2,3-dioxygenase productivity and decreased pTG201 stability. catechol 134-142 catechol 2,3-dioxygenase Pseudomonas putida 6-10 3036239-0 1987 Tyrosinase-catalyzed oxidation of dopa and related catechol(amine)s: a kinetic electron spin resonance investigation using spin-stabilization and spin label oximetry. catechol 51-59 tyrosinase Homo sapiens 0-10 3036239-1 1987 The oxidation of four catechol(amine)s by tyrosinase has been studied by electron spin resonance and optical methods. catechol 22-30 tyrosinase Homo sapiens 42-52 3472524-1 1987 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of phenolic and catechol drugs and neurotransmitters. catechol 80-88 sulfotransferase family 1A member 1 Homo sapiens 0-23 3472524-1 1987 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of phenolic and catechol drugs and neurotransmitters. catechol 80-88 sulfotransferase family 1A member 1 Homo sapiens 25-28 3105585-0 1987 Kinetic study on the suicide inactivation of tyrosinase induced by catechol. catechol 67-75 tyrosinase Homo sapiens 45-55 3105585-3 1987 Explicit equations of product vs. time have been developed for the multisubstrate mechanism of tyrosinase, and the kinetic parameters which characterize the enzyme acting on the suicide substrate catechol have been determined. catechol 196-204 tyrosinase Homo sapiens 95-105 3827241-6 1987 Purification of these residues by thin-layer chromatography and further analysis by gas chromatography-mass spectrometry indicated that cis-1,2-dihydroxy-1,2-dihydronaphthalene, 1-naphthol, salicylic acid, and catechol were metabolites of naphthalene. catechol 210-218 suppressor of cytokine signaling 1 Homo sapiens 136-141 2884573-0 1987 Inhibition of tyrosine hydroxylase in rabbit mesenteric artery and vas deferens by catechol oestrogens. catechol 83-91 LOC100008895 Oryctolagus cuniculus 14-34 2884573-2 1987 Both catechol oestrogens, 2-hydroxyoestradiol (2OHE2) and 2-hydroxyoesterone (2OHE1), inhibited TH activity in mesenteric artery and vas deferens in a concentration-dependent manner with potencies that were higher than those for noradrenaline but lower than that for dopamine. catechol 5-13 LOC100008895 Oryctolagus cuniculus 96-98 2884573-9 1987 It is concluded that catechol oestrogens inhibit TH activity with a potency comparable to noradrenaline and dopamine. catechol 21-29 LOC100008895 Oryctolagus cuniculus 49-51 3542192-5 1987 Here we describe a sensitive radiochemical assay for dihydrodiol dehydrogenase in which the oxidation of benzenedihydrodiol to pyrocatechol is coupled to O-methylation catalyzed by catechol-O-methyltransferase (EC 2.1.1.6). catechol 127-139 dihydrodiol dehydrogenase Rattus norvegicus 53-78 3542192-5 1987 Here we describe a sensitive radiochemical assay for dihydrodiol dehydrogenase in which the oxidation of benzenedihydrodiol to pyrocatechol is coupled to O-methylation catalyzed by catechol-O-methyltransferase (EC 2.1.1.6). catechol 127-139 catechol-O-methyltransferase Rattus norvegicus 181-209 3033538-1 1987 Temporal changes in plasma prolactin (PRL) levels caused by the administration of a number of different catechol estrogens to freely-moving conscious male rats were determined. catechol 104-112 prolactin Rattus norvegicus 27-36 3033538-1 1987 Temporal changes in plasma prolactin (PRL) levels caused by the administration of a number of different catechol estrogens to freely-moving conscious male rats were determined. catechol 104-112 prolactin Rattus norvegicus 38-41 3033538-4 1987 The effect on PRL secretion was found to be more pronounced when the catechol estrogens were administered to rats bearing implants of estradiol and could not be correlated with their Kd values for the estrogen receptor. catechol 69-77 prolactin Rattus norvegicus 14-17 3033538-7 1987 The experiments support the hypothesis that catechol estrogens generally act as short-term dopamine agonists, lowering PRL, but that those which possess estrogenic activity also show a more prolonged PRL-elevating effect. catechol 44-52 prolactin Rattus norvegicus 119-122 3780966-0 1986 Aliphatic side chain of catecholamine potentiates the stimulatory effect of the catechol part on the synthesis of nerve growth factor. catechol 24-32 nerve growth factor Mus musculus 114-133 3572026-5 1987 4-S-Cysteaminylphenol was almost comparable to L-dopa in cytotoxicity, suggesting that this phenol might be oxidized to the corresponding catechol by tyrosinase within the melanoma cells. catechol 138-146 tyrosinase Homo sapiens 150-160 3508913-3 1987 Dihydropteridine reductase inhibitory potency of multi-ring compounds containing a catechol-moiety was greater than that of single ring catecholic compounds, which in turn was greater than that of p-hydroxy-phenolic compounds. catechol 83-91 quinoid dihydropteridine reductase Rattus norvegicus 0-26 3020144-5 1986 Conversion to catechol oestrogens was tested in microsomes from the HPA, pituitary gland and liver, using a catechol-O-methyltransferase-coupled radioenzymatic assay. catechol 14-22 catechol-O-methyltransferase Rattus norvegicus 108-136 3015028-1 1986 The reactions of 3-ethylcatechol and 3-(methylthio)catechol with catechol 1,2-dioxygenase and catechol 2,3-dioxygenase from Pseudomonas putida were examined. catechol 24-32 catechol 2,3-dioxygenase Pseudomonas putida 94-118 3024022-14 1986 It is concluded that catechol oestrogens are excellent substrates for catechol-O-methyltransferase (COMT) in the rabbit aorta. catechol 21-29 catechol O-methyltransferase Oryctolagus cuniculus 70-98 3024022-14 1986 It is concluded that catechol oestrogens are excellent substrates for catechol-O-methyltransferase (COMT) in the rabbit aorta. catechol 21-29 catechol O-methyltransferase Oryctolagus cuniculus 100-104 3016262-0 1986 Catechol estrogens of the 1,1,2-triphenylbut-1-ene type: relationship between structure, estradiol receptor affinity, estrogenic and antiestrogenic properties, and mammary tumor inhibiting activities. catechol 0-8 estrogen receptor 1 (alpha) Mus musculus 89-107 3015028-2 1986 Both 3-substituted catechols are oxidized by catechol 2,3-dioxygenase at approximately 30% of the rate observed for catechol oxidation by this enzyme. catechol 19-27 catechol 2,3-dioxygenase Pseudomonas putida 45-69 2873064-1 1986 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of phenolic and catechol drugs and neurotransmitters. catechol 80-88 sulfotransferase family 1A member 1 Homo sapiens 0-23 2873064-1 1986 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of phenolic and catechol drugs and neurotransmitters. catechol 80-88 sulfotransferase family 1A member 1 Homo sapiens 25-28 6597720-1 1984 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catechol and phenolic drugs and xenobiotic compounds. catechol 67-75 sulfotransferase family 1A member 1 Homo sapiens 0-23 3730434-2 1986 The steady-state kinetics of ceruloplasmin-catalyzed oxidation of organic substrates (pyrocatechine, adrenaline, rho-phenyldiamine) and Fe(II) was analyzed. catechol 86-99 ceruloplasmin Homo sapiens 29-42 2874501-0 1986 Direct inhibition of tyrosine hydroxylase from PC-12 cells by catechol derivatives. catechol 62-70 tyrosine hydroxylase Rattus norvegicus 21-41 2874501-1 1986 Several drugs with a catechol moiety were studied for their potency to inhibit tyrosine hydroxylase (TH) from PC-12 cells in vitro. catechol 21-29 tyrosine hydroxylase Rattus norvegicus 79-99 3710285-6 1986 MgSO4 and propranolol had no effect on the activities of COMT and MAO at 6 and 24 h. These results suggest that COMT and MAO activities in the placenta can be modulated by antihypertensive drugs and, therefore, these drugs might affect local catechol metabolism. catechol 242-250 catechol-O-methyltransferase Homo sapiens 112-116 2998732-0 1985 Normal and recombinant human growth hormone administered by constant infusion feminize catechol estrogen formation by rat liver microsomes. catechol 87-95 growth hormone 1 Homo sapiens 29-43 3753600-11 1986 Based on the above results, a catechol-binding site model for catechol O-methyltransferase is proposed in which the two phenolic hydroxyl groups of catechol substrates are postulated to be approximately equally spaced from the methyl group of the cosubstrate S-adenosylmethionine. catechol 30-38 catechol-O-methyltransferase Homo sapiens 62-90 3025758-0 1986 Effect of catechol estrogens on the preovulatory content of luteinizing hormone-releasing hormone in the median eminence of the rat. catechol 10-18 gonadotropin releasing hormone 1 Rattus norvegicus 60-97 3025758-4 1986 Thus the catechol estrogens block the LH surge at its usual time by influencing the changes in the concentration of LHRH in the median eminence on proestrus. catechol 9-17 gonadotropin releasing hormone 1 Rattus norvegicus 116-120 3025758-5 1986 Since the catechol estrogens have short biological half-lives, their effect on the LHRH content in the afternoon must originate in the morning at the time of the endogenous estradiol (E2) peak. catechol 10-18 gonadotropin releasing hormone 1 Rattus norvegicus 83-87 3855967-1 1985 Phenol sulfotransferase (PST; EC 2.8.2.1) catalyzes the sulfate conjugation of phenolic and catechol neurotransmitters and drugs. catechol 92-100 sulfotransferase family 1A member 1 Homo sapiens 0-23 3855967-1 1985 Phenol sulfotransferase (PST; EC 2.8.2.1) catalyzes the sulfate conjugation of phenolic and catechol neurotransmitters and drugs. catechol 92-100 sulfotransferase family 1A member 1 Homo sapiens 25-28 2859176-5 1985 3-Methoxydenopamine (M-2) and 3-hydroxy-4-O-methyldenopamine (iso-M-2) were formed via the catechol intermediate M-4, when denopamine was incubated with the rat liver 9000g supernatant fraction in the presence of the NADPH-generating system and S-adenosyl-L-methionine. catechol 91-99 cholinergic receptor, muscarinic 4 Rattus norvegicus 113-116 6597720-1 1984 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catechol and phenolic drugs and xenobiotic compounds. catechol 67-75 sulfotransferase family 1A member 1 Homo sapiens 25-28 6540166-4 1984 The isomeric catechol estrogen 4-hydroxyestrone effectively inhibited the LH surge when given at 0900 h, but not if injected at 1000 or 1200 h. In contrast, the nonestrogenic 2-hydroxyestradiol-17 alpha was effective in blocking the LH surge when given at 0900 or 1000 h. Rats treated with 2OHE2-17 beta at 1000 h responded normally to exogenous LHRH administration in the afternoon, indicating that the action of 2OHE2-17 beta is at the hypothalamic level. catechol 13-21 gonadotropin releasing hormone 1 Rattus norvegicus 346-350 6491941-0 1984 Synthesis of bridged catechol-homocysteine derivatives as potential inhibitors of catechol O-methyltransferase. catechol 21-29 catechol-O-methyltransferase Homo sapiens 82-110 6491941-1 1984 Catechol derivatives, covalently joined to homocysteine by sulfide or sulfonium linkages, were synthesized as potential catechol O-methyltransferase multisubstrate inhibitors which might bridge the enzymatic binding sites for the catechol substrate and the amino acid portion of the methyl donor S-adenosylmethionine. catechol 0-8 catechol-O-methyltransferase Homo sapiens 120-148 6589361-1 1984 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catecholamines and phenol and catechol drugs. catechol 67-75 sulfotransferase family 1A member 1 Homo sapiens 0-23 6589361-1 1984 Phenol sulfotransferase (PST) catalyzes the sulfate conjugation of catecholamines and phenol and catechol drugs. catechol 67-75 sulfotransferase family 1A member 1 Homo sapiens 25-28 6547725-2 1984 A newly synthesized catechol compound, 2-(3,4-dihydroxyphenyl)naphtho [1,2-d]thiazole is used as a highly fluorogenic substrate for catechol-O-methyltransferase; the m- and p-methylated products formed enzymatically from the substrate under the optimum conditions, after extraction with n-hexane--chloroform, are separated by normal-phase chromatography on LiChrosorb Si 100. catechol 20-28 catechol-O-methyltransferase Homo sapiens 132-160 6431310-0 1984 The TRH analogue CG3509 increases in vivo catechol/ascorbate oxidation in the N. accumbens but not in the striatum of the rat. catechol 42-50 thyrotropin releasing hormone Rattus norvegicus 4-7 6714437-5 1984 The genetically controlled level of COMT activity in the RBC reflects the level of enzyme activity in other tissues and is significantly correlated with individual variations in the methyl conjugation of catechol drugs such as L-dopa and methyldopa. catechol 204-212 catechol-O-methyltransferase Homo sapiens 36-40 6325410-2 1984 Addition of 2-hydroxyestrone to the cell cultures in concentration of 10(-9) - 10(-6) M had no effect on cell growth and proliferation because of rapid O-methylation of the catechol estrogen by catechol O-methyltransferase which is highly active in these cells. catechol 173-181 catechol-O-methyltransferase Homo sapiens 194-222 6202430-2 1984 The metabolites of benzene produced in bone marrow cells by the microsomal cytochrome P-450 are thought to be phenol, catechol, hydroquinone and p-benzoquinone (Andrews et al., Life Sci., 25 (1979) 567; Irons et al., Chem.-Biol. catechol 118-126 cytochrome P-450 Oryctolagus cuniculus 75-91 6855232-11 1983 The presence of the ethynyl group of ethynyl estradiol impedes attack at C-16 and hydroxylation at C-2 to form catechol estrogens becomes a major pathway, whereas the 11 beta-methoxy group of moxestrol impedes hydroxylation at C-2 and ring D hydroxylated products of moxestrol are formed. catechol 111-119 complement C2 Homo sapiens 99-102 6320967-3 1984 The possible role of catechol estrogen, a potent inhibitor of catechol-O-methyltransferase, in these effects is considered. catechol 21-29 catechol-O-methyltransferase Rattus norvegicus 62-90 6098975-1 1983 Since catechol estrogens are potent competitive inhibitors of catechol-O-methyl transferase (COMT), it has been suggested that they may prolong the half-life of catecholamines which in turn can cause hypertension. catechol 6-14 catechol-O-methyltransferase Rattus norvegicus 62-91 6098975-1 1983 Since catechol estrogens are potent competitive inhibitors of catechol-O-methyl transferase (COMT), it has been suggested that they may prolong the half-life of catecholamines which in turn can cause hypertension. catechol 6-14 catechol-O-methyltransferase Rattus norvegicus 93-97 6193387-5 1983 Catechol-aporphines prevented binding of 3H-NCA to calf caudate membranes by up to 30%, but this effect was not stereoselective and was lost at concentrations of 3H-NCA above 100 nM. catechol 0-8 CEA cell adhesion molecule 4 Homo sapiens 44-47 6193387-5 1983 Catechol-aporphines prevented binding of 3H-NCA to calf caudate membranes by up to 30%, but this effect was not stereoselective and was lost at concentrations of 3H-NCA above 100 nM. catechol 0-8 CEA cell adhesion molecule 4 Homo sapiens 165-168 6311216-0 1983 Regulation of cytochrome P-450-dependent catechol estrogen formation in rat liver microsomes. catechol 41-49 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 14-30 6136632-2 1983 The catecholestrogen may act by its catechol A ring on the nucleus arcuatus COMT, consequently leaving the noradrenaline free. catechol 4-12 catechol-O-methyltransferase Rattus norvegicus 76-80 6136632-4 1983 This assumption is supported by the observations that the catecholestrogen effect can be mimicked by homocystein, an aminoacid able also to inhibit COMT activity, having neither a steroid nor a catechol structure. catechol 58-66 catechol-O-methyltransferase Rattus norvegicus 148-152 6136632-7 1983 The evidence for catecholestrogen action upon COMT, an outside membrane enzyme involved in the process of catecholamine degradation, supports the idea of a catechol action for 2-OHE2. catechol 17-25 catechol-O-methyltransferase Rattus norvegicus 46-50 6310245-0 1983 Catechol estrogens and the control of gonadotropin and prolactin secretion in man. catechol 0-8 prolactin Homo sapiens 55-64 6310245-4 1983 There have been reports that the catechol estrogen 2-hydroxyestrone (2-OHE1) might act as a partial estrogen antagonist, stimulating gonadotropin secretion; and that it might have dopamine-like effects, suppressing the secretion of PRL. catechol 33-41 prolactin Homo sapiens 232-235 6310245-5 1983 In studies testing the chronic and acute effects of catechol estrogens on LH, FSH, and PRL in men and women, we found that they behaved as estrogens, suppressing gonadotropins when given in doses high enough to compensate for their rapid clearance and degradation. catechol 52-60 prolactin Homo sapiens 87-90 6305935-2 1983 It was found that the NADPH-dependent transformation of benzene to water-soluble metabolites and to phenol catalyzed by cytochrome P-450 LM2 in membrane vesicles was inhibited by catalase, horseradish peroxidase, superoxide dismutase, and hydroxyl radical scavengers such as mannitol, dimethyl sulfoxide, and catechol, indicating the participation of hydrogen peroxide, superoxide anions, and hydroxyl radicals in the process. catechol 309-317 cytochrome P-450 Oryctolagus cuniculus 120-136 6300234-5 1983 These results indicate that aggregation was due to MPO-H2O2-mediated oxidation of catechol to orthoquinone, which was deemed to be directly responsible for cross-linking by non-enzymic biochemical reactions. catechol 82-90 myeloperoxidase Homo sapiens 51-54 6131099-4 1983 The catechol oestrogen 2-hydroxyoestradiol inhibited the release of prolactin from normal rat pituitary glands in vitro but measurement of catechol oestrogens in the hypothalamus showed no differences between young and old tumorous or non-tumorous rats. catechol 4-12 prolactin Rattus norvegicus 68-77 6299293-0 1983 Mestranol-induced hypertension: characterization of cytochrome P-450 dependent catechol estrogen formation in brain microsomes. catechol 79-87 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 52-68 6315964-0 1983 Inhibition of dihydropteridine reductase by catechol estrogens. catechol 44-52 quinoid dihydropteridine reductase Homo sapiens 14-40 6315964-1 1983 Catechol estrogens, such as 2-hydroxyestriol, 2-hydroxyestradiol, and 2-hydroxyestrone, inhibit human liver dihydropteridine reductase noncompetitively with Ki values ranging from 1.5 to 4.6 X 10(-6)M. Catechol estrogens lose approximately half of their inhibitory potency if the C-2 hydroxyl groups are methylated. catechol 0-8 quinoid dihydropteridine reductase Homo sapiens 108-134 6315964-1 1983 Catechol estrogens, such as 2-hydroxyestriol, 2-hydroxyestradiol, and 2-hydroxyestrone, inhibit human liver dihydropteridine reductase noncompetitively with Ki values ranging from 1.5 to 4.6 X 10(-6)M. Catechol estrogens lose approximately half of their inhibitory potency if the C-2 hydroxyl groups are methylated. catechol 202-210 quinoid dihydropteridine reductase Homo sapiens 108-134 6315964-4 1983 These results support the hypothesis that catechol estrogens may interfere with catecholamine metabolism by acting as inhibitors of enzymes involved in catecholamine metabolism, such as dihydropteridine reductase. catechol 42-50 quinoid dihydropteridine reductase Homo sapiens 186-212 6856588-7 1983 We speculate that the apparent activation of catechol-O-methyl transferase pathway, observed in our studies on MAO inhibition, may play an important role in limiting NA transfer towards the fetus in toxaemic pregnancies associated with the reduction in placental MAO. catechol 45-53 monoamine oxidase A Rattus norvegicus 111-114 6856588-7 1983 We speculate that the apparent activation of catechol-O-methyl transferase pathway, observed in our studies on MAO inhibition, may play an important role in limiting NA transfer towards the fetus in toxaemic pregnancies associated with the reduction in placental MAO. catechol 45-53 monoamine oxidase A Rattus norvegicus 263-266 6127206-0 1982 The catechol estrogen, 2-hydroxyestradiol-17 alpha, is formed from estradiol-17 alpha by hypothalamic tissue in vitro and inhibits tyrosine hydroxylase. catechol 4-12 tyrosine hydroxylase Rattus norvegicus 131-151 6810464-7 1982 Tyrosinase has the unusual property of catalyzing three distinct reactions within a single biochemical pathway: the hydroxylation of a monophenol, the dehydrogenation of a catechol, and the dehydrogenation of a dihydroxyindole. catechol 172-180 tyrosinase Homo sapiens 0-10 7132559-7 1982 From these results it may be concluded that a fully extended side chain conformation is required for NMT substrate activity, and the better substrate activity for 6,7-D2HX compared to 4 is consistent with a proper catechol orientation for interaction with the norepinephrine (NE) binding site of NMT. catechol 214-222 N-myristoyltransferase 1 Homo sapiens 296-299 6275286-0 1981 Temporal and other effects of catechol estrogens on prolactin secretion in the rat. catechol 30-38 prolactin Rattus norvegicus 52-61 6284121-2 1982 The kinetics of reduction of cytochrome c by catechol(s), quinol(s) and related compounds were investigated by stopped-flow spectrophotometry. catechol 45-53 cytochrome c, somatic Homo sapiens 29-41 7074167-0 1982 [Kinetics of the catalytic oxidation of catechol in aqueous solutions of ceruloplasmin in the presence of Fe3+]. catechol 40-48 ceruloplasmin Homo sapiens 73-86 7074167-1 1982 The kinetics of oxidation of catechol in aqueous solutions containing ceruloplasmin and Fe3+, were studied. catechol 29-37 ceruloplasmin Homo sapiens 70-83 6799844-2 1981 The assay is based on the O-methylation of the catechol moiety utilizing S-[3H-methyl]-adenosyl-L-methionine and a partially purified catechol-O-methyl transferase to form the various O-[3H-methyl]-catechol derivatives. catechol 47-55 catechol-O-methyltransferase Homo sapiens 134-163 7268425-0 1981 Metabolism of catechol estrogens by erythrocyte catechol-O methyltransferase. catechol 14-22 catechol-O-methyltransferase Homo sapiens 48-76 7240374-3 1981 The total extent of hydroxylation estradiol at either C-16 to more estrogenic metabolites or at C-2 to the catechol estrogens was determined by a radiometric method in the human. catechol 107-115 complement C2 Homo sapiens 96-99 762061-4 1979 The COMT I and COMT II have been purified 450- and 205-fold, respectively, from rat liver by a newly developed procedure which gives homogeneous enzyme preparations with respect to catechol-methylating activities. catechol 181-189 catechol-O-methyltransferase Rattus norvegicus 4-8 7108526-2 1982 The method is based on the conversion of catechol to [3H]guaiacol by catechol-O-methyltransferase in the presence of Mg2+, adenosine deaminase and S-adenosyl L-[methyl-3H]methionine. catechol 41-49 catechol-O-methyltransferase Homo sapiens 69-97 7426122-2 1980 All of the catechol estrogens tested have similar Km"s for 0-methylation (9-14 muM). catechol 11-19 latexin Homo sapiens 79-82 7213760-1 1981 Salicylate hydroxylase (salicylate, NADH: oxygen oxidoreductase (1-hydroxylating, decarboxylating), EC 1.14.13.1) in Pseudomonas putida catalyzed hydroxylation of the substrate analogue, salicylaldehyde, to form catechol and formate with stoichiometric consumption of NADH and O2. catechol 212-220 salicylate hydroxylase Pseudomonas putida 0-22 6261427-5 1981 In view of the reports indicating that inhibitors of catechol 0-methyl transferase (COMT) might act as antineoplastic agents due to their interference with t-RNA methylases and since catechol estrogens inhibit COMT, the present results suggest that endogenous synthesis of catechol estrogens may play an important role in the pathophysiology of uterine leiomyoma. catechol 53-61 catechol-O-methyltransferase Homo sapiens 84-88 6261427-5 1981 In view of the reports indicating that inhibitors of catechol 0-methyl transferase (COMT) might act as antineoplastic agents due to their interference with t-RNA methylases and since catechol estrogens inhibit COMT, the present results suggest that endogenous synthesis of catechol estrogens may play an important role in the pathophysiology of uterine leiomyoma. catechol 53-61 catechol-O-methyltransferase Homo sapiens 210-214 6261427-5 1981 In view of the reports indicating that inhibitors of catechol 0-methyl transferase (COMT) might act as antineoplastic agents due to their interference with t-RNA methylases and since catechol estrogens inhibit COMT, the present results suggest that endogenous synthesis of catechol estrogens may play an important role in the pathophysiology of uterine leiomyoma. catechol 183-191 catechol-O-methyltransferase Homo sapiens 84-88 6261427-5 1981 In view of the reports indicating that inhibitors of catechol 0-methyl transferase (COMT) might act as antineoplastic agents due to their interference with t-RNA methylases and since catechol estrogens inhibit COMT, the present results suggest that endogenous synthesis of catechol estrogens may play an important role in the pathophysiology of uterine leiomyoma. catechol 183-191 catechol-O-methyltransferase Homo sapiens 210-214 7006735-5 1981 The localization of COMT in the leptomeninges, choroid plexus, and ciliary epithelium is consistent with a role for this enzyme in the separation of catechol compounds synthesized in the central nervous system, from those of peripheral origin. catechol 149-157 catechol-O-methyltransferase Rattus norvegicus 20-24 7437264-7 1980 4 Kinetic studies with pooled uraemic plasma demonstrate that inhibition of COMT by uraemic plasma is uncompetitive with respect to both the catechol substrate and the methyl donor for the reaction, S-adenosyl-L-methionine. catechol 141-149 catechol-O-methyltransferase Homo sapiens 76-80 6252068-0 1980 Response of serum prolactin to catechol estrogen in the immature rat. catechol 31-39 prolactin Rattus norvegicus 18-27 6252068-1 1980 The response of serum prolactin to the catechol estrogens, 2-hydroxyestrone (2-OH E1) and 2-hydroxyestradiol (2-OH E2) and their primary estrogens, estrone (E1) and estradiol (E2), was studied in 35-day-old male rats. catechol 39-47 prolactin Rattus norvegicus 22-31 7205995-5 1980 The reactivity of several commonly administered catechol drugs with COMT is described and the possible implications discussed. catechol 48-56 catechol-O-methyltransferase Homo sapiens 68-72 762061-4 1979 The COMT I and COMT II have been purified 450- and 205-fold, respectively, from rat liver by a newly developed procedure which gives homogeneous enzyme preparations with respect to catechol-methylating activities. catechol 181-189 catechol-O-methyltransferase Rattus norvegicus 15-19 27508-0 1978 Direct inhibition of tyrosine hydroxylase activity by catechol estrogens. catechol 54-62 tyrosine hydroxylase Homo sapiens 21-41 27508-1 1978 Catechol estrogens, the 2-hydroxylated metabolites of estrogens, recently shown to be formed in brain, inhibit tyrosine hydroxylase, the enzyme that catalyzes the pivotal step in the biosynthesis of the neurotransmitters dopamine and norepinephrine. catechol 0-8 tyrosine hydroxylase Homo sapiens 111-131 677197-1 1978 Catechol-O-methyltransferase (COMT) is the enzyme that converts catechols, e.g., catecholamines and catechol estrogens, to their methyl ethers. catechol 64-72 catechol-O-methyltransferase Homo sapiens 0-28 677197-1 1978 Catechol-O-methyltransferase (COMT) is the enzyme that converts catechols, e.g., catecholamines and catechol estrogens, to their methyl ethers. catechol 64-72 catechol-O-methyltransferase Homo sapiens 30-34 671023-0 1978 The catechol estrogen, 2-hydroxyestradiol, inhibits catechol-O-methyltransferase activity in neuroblastoma cells. catechol 4-12 catechol-O-methyltransferase Homo sapiens 52-80 16657046-9 1969 When catechol replaced benzidine-2 HCl as the electron donor, 1 cationic and 2 anionic peroxidase isozymes did not form. catechol 5-13 lignin-forming anionic peroxidase-like Nicotiana tabacum 87-97 145258-2 1977 The convulsive activity induced by catechol has been examined in anaesthetized mice either by determining the CD50 for the convulsions in drug-treated and control animals, or by studying the effects of various drugs on the total whole body activity. catechol 35-43 intercellular adhesion molecule 5, telencephalin Mus musculus 110-114 913328-0 1977 Catechol estrogen-forming enzyme of brain: demonstration of a cytochrome p450 monooxygenase. catechol 0-8 cytochrome P450 family 20 subfamily A member 1 Homo sapiens 62-91 925137-1 1977 In a study designed to evaluate the kinetics of catechol estrogen formation from plasma estrone in vivo, we obtained evidence that the red blood cell (RBC) enzyme, catechol-O-methyl transferase, catalyzes the transformation of 2-hydroxyestrone to 2-methoxyestrone. catechol 48-56 catechol-O-methyltransferase Homo sapiens 164-193 410418-0 1977 Cytochrome P-450 and NADPH cytochrome c reductase in rat brain: formation of catechols and reactive catechol metabolites. catechol 77-85 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 912603-3 1977 However, a comparison of the crude particulate COMT and the solubilized enzyme shows that there is a significant difference in their affinity for catechol substrates. catechol 146-154 catechol-O-methyltransferase Rattus norvegicus 47-51 217444-10 1979 The ratio of the rate constants with .OH and O-2 of 100 again demonstrates that any oxidation reaction by the latter radical is unspecific due to the more efficient reaction of .OH radicals, leading to the same products with catechol compounds. catechol 225-233 immunoglobulin kappa variable 1D-39 Homo sapiens 45-48 186306-0 1976 On the interaction of some catechol derivatives with the iron atom of soybean lipoxygenase. catechol 27-35 linoleate 9S-lipoxygenase-4 Glycine max 78-90 170064-6 1975 These results demonstrate the potential for interaction between catechol estrogens and estrogen receptor in rat brain and pituitary of a magnitude which could be biologically significant. catechol 64-72 estrogen receptor 1 Rattus norvegicus 87-104 4341530-1 1972 Purification and properties of the catechol-forming enzyme, 3,5-cyclohexadiene-1,2-diol-1-carboxylic acid (NAD + ) oxidoreductase (decarboxylating). catechol 35-43 thioredoxin reductase 1 Homo sapiens 107-129 14442503-1 1960 Histidine decarboxylase activity of mouse tissues is increased by stress and by injection of epinephrine and norepinephrine, suggesting a balance between histamine and catechol amines producing a component of circulatory homeostasis. catechol 168-176 histidine decarboxylase Mus musculus 0-23 16748549-0 1949 The oxidation of catechol and homocatechol by tyrosinase in the presence of amino-acids. catechol 17-25 tyrosinase Homo sapiens 46-56 34028358-11 2021 CAQ was the only measure improved significantly by internet-based cognitive behavioral therapy when compared with treatment as usual (beta=-2.58, 95% CI -4.75 to -0.42, P=.02) before adjusting for multiple comparisons. catechol 0-3 ATPase H+ transporting V0 subunit a2 Homo sapiens 134-141 33690099-0 2021 Microcapsule-based biosensor containing catechol for the reagent-free inhibitive detection of benzoic acid by tyrosinase. catechol 40-48 tyrosinase Homo sapiens 110-120 33690099-6 2021 Reagentless biosensors based on different deposited quantity of tyrosinase (100, 200, 400 and 600 mug) were investigated for the detection of catechol and applied to the detection of benzoic acid as inhibitor. catechol 142-150 tyrosinase Homo sapiens 64-74 34027136-1 2021 Catechol O-methyltransferase, an enzyme involved in the metabolism of catechol containing compounds, catalyzes the transfer of a methyl group between S-adenosylmethionine and the hydroxyl groups of the catechol. catechol 70-78 catechol-O-methyltransferase Homo sapiens 0-28 34027136-1 2021 Catechol O-methyltransferase, an enzyme involved in the metabolism of catechol containing compounds, catalyzes the transfer of a methyl group between S-adenosylmethionine and the hydroxyl groups of the catechol. catechol 202-210 catechol-O-methyltransferase Homo sapiens 0-28 33289235-5 2021 Catechol modulated differential DNA damage effects by activating ATM/ATR pathways and showed enhanced gamma-H2AX expression, as an indicator for DNA double-stranded breaks. catechol 0-8 ATM serine/threonine kinase Homo sapiens 65-68 33932413-9 2021 Combined with CD44 receptor targeting ability of hyaluronate and the merits of nanogel, the catechol modified hyaluronate nanogel exhibited as an efficient chemotherapeutic formulation of BTZ for cancer treatment. catechol 92-100 CD44 molecule (Indian blood group) Homo sapiens 14-18 33932529-6 2021 Collectively, our findings not only suggested that the strong hCOMT inhibition of vine tea has guiding significance in the drug exposure of catechol drugs, but also identified a promising lead compound for developing more efficacious hCOMT inhibitors. catechol 140-148 catechol-O-methyltransferase Homo sapiens 62-67 33199105-2 2021 In this work, residue activated carbon (RAC) was successfully synthesized from catechol distillation residue by a simple activation process based on two steps. catechol 79-87 AKT serine/threonine kinase 1 Homo sapiens 40-43 33486434-2 2021 The method is based on the oxidation of pyrocatechol (PC) to give quinone form which by oxidative coupling with aminyl radical of 4-aminoantipyrine (4-AAP) resulting from H2O2/CAT to produce a pink colored quinone-imine product with lambdamax = 530 nm in a 100 mmol/L of tris buffer of pH 9.8 at room temperature (30 C). catechol 40-52 catalase Homo sapiens 176-179 33486434-2 2021 The method is based on the oxidation of pyrocatechol (PC) to give quinone form which by oxidative coupling with aminyl radical of 4-aminoantipyrine (4-AAP) resulting from H2O2/CAT to produce a pink colored quinone-imine product with lambdamax = 530 nm in a 100 mmol/L of tris buffer of pH 9.8 at room temperature (30 C). catechol 54-56 catalase Homo sapiens 176-179 33840199-1 2021 COMT (Catechol-O-methyl transferase), an enzyme that metabolizes catechol, requires magnesium (Mg2+) to maintain its activity. catechol 65-73 catechol-O-methyltransferase Mus musculus 0-4 33840199-1 2021 COMT (Catechol-O-methyl transferase), an enzyme that metabolizes catechol, requires magnesium (Mg2+) to maintain its activity. catechol 65-73 catechol-O-methyltransferase Mus musculus 6-35 33710870-2 2021 cis-[Cr(HMC)(Cat)]+ complexes (Cat = catecholate, [1]+; tetrachlorocatecholate, [2]+; and 3,5-di-tert-butylcatecholate, [3]+) were prepared from the reaction between appropriate catechol and [CrIII(HMC)Cl2]Cl reduced in situ by zinc. catechol 37-45 catalase Homo sapiens 13-16 33289235-5 2021 Catechol modulated differential DNA damage effects by activating ATM/ATR pathways and showed enhanced gamma-H2AX expression, as an indicator for DNA double-stranded breaks. catechol 0-8 ATR serine/threonine kinase Homo sapiens 69-72 33579806-1 2021 Objective: Non-catechol based high affinity selective dopamine D1 receptor (D1R) agonists were recently described, and candidate PET ligands were selected based on favorable properties. catechol 15-23 dopamine receptor D1 Homo sapiens 54-74 33389592-7 2021 Our results showed that the compounds with one or two catechol moieties showed strong hIAPP aggregation inhibitory activity and Abeta42/hIAPP disaggregation activity; and the non-catechol type compounds showed little or no activity. catechol 54-62 islet amyloid polypeptide Homo sapiens 86-91 33389592-7 2021 Our results showed that the compounds with one or two catechol moieties showed strong hIAPP aggregation inhibitory activity and Abeta42/hIAPP disaggregation activity; and the non-catechol type compounds showed little or no activity. catechol 54-62 islet amyloid polypeptide Homo sapiens 136-141 33289420-1 2021 Catechol-O-methyltransferase (COMT) methylates both endogenous and exogenous catechol compounds to inactive and safe metabolites. catechol 77-85 catechol-O-methyltransferase Rattus norvegicus 0-28 33289420-1 2021 Catechol-O-methyltransferase (COMT) methylates both endogenous and exogenous catechol compounds to inactive and safe metabolites. catechol 77-85 catechol-O-methyltransferase Rattus norvegicus 30-34 33389924-1 2021 Objective: The COMT enzyme synthesized from the Catechol-O-Methyltransferase (COMT) gene detoxifies the carcinogenic catechol estrogens. catechol 117-125 catechol-O-methyltransferase Homo sapiens 15-19 33389924-1 2021 Objective: The COMT enzyme synthesized from the Catechol-O-Methyltransferase (COMT) gene detoxifies the carcinogenic catechol estrogens. catechol 117-125 catechol-O-methyltransferase Homo sapiens 48-76 33389924-1 2021 Objective: The COMT enzyme synthesized from the Catechol-O-Methyltransferase (COMT) gene detoxifies the carcinogenic catechol estrogens. catechol 117-125 catechol-O-methyltransferase Homo sapiens 78-82 33571432-2 2021 Here, we present five cryoelectron microscopy (cryo-EM) structures of the dopamine D1 receptor (DRD1) coupled to Gs heterotrimer in complex with three catechol-based agonists, a non-catechol agonist, and a positive allosteric modulator for endogenous dopamine. catechol 151-159 dopamine receptor D1 Homo sapiens 74-94 33571432-2 2021 Here, we present five cryoelectron microscopy (cryo-EM) structures of the dopamine D1 receptor (DRD1) coupled to Gs heterotrimer in complex with three catechol-based agonists, a non-catechol agonist, and a positive allosteric modulator for endogenous dopamine. catechol 151-159 dopamine receptor D1 Homo sapiens 96-100 33571432-2 2021 Here, we present five cryoelectron microscopy (cryo-EM) structures of the dopamine D1 receptor (DRD1) coupled to Gs heterotrimer in complex with three catechol-based agonists, a non-catechol agonist, and a positive allosteric modulator for endogenous dopamine. catechol 182-190 dopamine receptor D1 Homo sapiens 74-94 33571432-2 2021 Here, we present five cryoelectron microscopy (cryo-EM) structures of the dopamine D1 receptor (DRD1) coupled to Gs heterotrimer in complex with three catechol-based agonists, a non-catechol agonist, and a positive allosteric modulator for endogenous dopamine. catechol 182-190 dopamine receptor D1 Homo sapiens 96-100 33889823-4 2021 Our screen revealed that KGD1 (a key gene in the tricarboxylic acid cycle) deletion improved tolerance to adipic acid and its toxic precursor, catechol. catechol 143-151 alpha-ketoglutarate dehydrogenase KGD1 Saccharomyces cerevisiae S288C 25-29 33152859-2 2021 The chemical mechanism that hexose oxidase recucing the melanins of dark spots was discussed basis on the UPLC-TOF-MS analysis of the polyphenol oxidase (PPO)-catechol system. catechol 159-167 protoporphyrinogen oxidase Homo sapiens 134-152 33152859-2 2021 The chemical mechanism that hexose oxidase recucing the melanins of dark spots was discussed basis on the UPLC-TOF-MS analysis of the polyphenol oxidase (PPO)-catechol system. catechol 159-167 protoporphyrinogen oxidase Homo sapiens 154-157 33068897-3 2021 The developed sensing system is based on TYR catalyzing the hydroxylation of mono-phenol to o-diphenol and the conversion of fluorescence copolymer (FCP) blue emission (430 nm) and green emission (535 nm) in the presence of PEI. catechol 92-102 tyrosinase Homo sapiens 41-44 32623742-6 2021 RESULTS: We found 150 mM of catechol and pH 7.0 were the optimal condition for the maximum activity for the PPO assay. catechol 28-36 polyphenol oxidase B, chloroplastic Solanum lycopersicum 108-111 33538598-3 2021 In this study, using mussel adhesive-inspired catechol chemistry, we developed a functional CS hydrogel that exhibits tunable physical and mechanical properties as well as excellent tissue adhesion for efficient integration with native tissues. catechol 46-54 citrate synthase Homo sapiens 92-94 33538598-4 2021 Various properties of the developed catechol-functionalized CS (CS-CA) hydrogel, including swelling, degradation, mechanical properties, and adhesiveness, could be tailored by varying the conjugation ratio of the catechol group to the CS backbone and the concentration of the CS-CA conjugates. catechol 36-44 citrate synthase Homo sapiens 60-62 33538598-4 2021 Various properties of the developed catechol-functionalized CS (CS-CA) hydrogel, including swelling, degradation, mechanical properties, and adhesiveness, could be tailored by varying the conjugation ratio of the catechol group to the CS backbone and the concentration of the CS-CA conjugates. catechol 36-44 citrate synthase Homo sapiens 64-69 33538598-4 2021 Various properties of the developed catechol-functionalized CS (CS-CA) hydrogel, including swelling, degradation, mechanical properties, and adhesiveness, could be tailored by varying the conjugation ratio of the catechol group to the CS backbone and the concentration of the CS-CA conjugates. catechol 36-44 citrate synthase Homo sapiens 64-66 33538598-4 2021 Various properties of the developed catechol-functionalized CS (CS-CA) hydrogel, including swelling, degradation, mechanical properties, and adhesiveness, could be tailored by varying the conjugation ratio of the catechol group to the CS backbone and the concentration of the CS-CA conjugates. catechol 36-44 citrate synthase Homo sapiens 276-281 33538598-4 2021 Various properties of the developed catechol-functionalized CS (CS-CA) hydrogel, including swelling, degradation, mechanical properties, and adhesiveness, could be tailored by varying the conjugation ratio of the catechol group to the CS backbone and the concentration of the CS-CA conjugates. catechol 213-221 citrate synthase Homo sapiens 60-62 33538598-4 2021 Various properties of the developed catechol-functionalized CS (CS-CA) hydrogel, including swelling, degradation, mechanical properties, and adhesiveness, could be tailored by varying the conjugation ratio of the catechol group to the CS backbone and the concentration of the CS-CA conjugates. catechol 213-221 citrate synthase Homo sapiens 64-69 33538598-4 2021 Various properties of the developed catechol-functionalized CS (CS-CA) hydrogel, including swelling, degradation, mechanical properties, and adhesiveness, could be tailored by varying the conjugation ratio of the catechol group to the CS backbone and the concentration of the CS-CA conjugates. catechol 213-221 citrate synthase Homo sapiens 64-66 32902887-3 2020 KEY FINDINGS: Catechol significantly elevated glutathione level, superoxide dismutase and catalase activities, while depleting malondialdehyde and nitric oxide levels. catechol 14-22 catalase Homo sapiens 90-98 33717608-1 2021 Mammalian catechol-O-methyltransferases (COMT) are an important class of conjugative enzymes, which play a key role in the metabolism and inactivation of catechol neurotransmitters, catechol estrogens and a wide range of endobiotics and xenobiotics that bear the catechol group. catechol 10-18 catechol-O-methyltransferase Homo sapiens 41-45 33717608-1 2021 Mammalian catechol-O-methyltransferases (COMT) are an important class of conjugative enzymes, which play a key role in the metabolism and inactivation of catechol neurotransmitters, catechol estrogens and a wide range of endobiotics and xenobiotics that bear the catechol group. catechol 154-162 catechol-O-methyltransferase Homo sapiens 10-39 33717608-1 2021 Mammalian catechol-O-methyltransferases (COMT) are an important class of conjugative enzymes, which play a key role in the metabolism and inactivation of catechol neurotransmitters, catechol estrogens and a wide range of endobiotics and xenobiotics that bear the catechol group. catechol 154-162 catechol-O-methyltransferase Homo sapiens 41-45 33717608-1 2021 Mammalian catechol-O-methyltransferases (COMT) are an important class of conjugative enzymes, which play a key role in the metabolism and inactivation of catechol neurotransmitters, catechol estrogens and a wide range of endobiotics and xenobiotics that bear the catechol group. catechol 154-162 catechol-O-methyltransferase Homo sapiens 10-39 33717608-1 2021 Mammalian catechol-O-methyltransferases (COMT) are an important class of conjugative enzymes, which play a key role in the metabolism and inactivation of catechol neurotransmitters, catechol estrogens and a wide range of endobiotics and xenobiotics that bear the catechol group. catechol 154-162 catechol-O-methyltransferase Homo sapiens 41-45 33141121-5 2020 Selective incorporation of catechol in variable and C-terminal region of CLP enhanced interaction between inter- and intra-triple-helical collagen molecules that resulted in a structure resembling higher-order native collagen fibril. catechol 27-35 collagen type XX alpha 1 chain Homo sapiens 73-76 33141121-6 2020 Turbidity analysis indicated that the triple-helical CLP self-assembled at neutral pH via a catechol intra-crosslinking mechanism. catechol 92-100 collagen type XX alpha 1 chain Homo sapiens 53-56 33141121-7 2020 After self-assembly, only DOPA-encoded CLP formed branched filamentous structures suggesting that catechol mediated network coordination. catechol 98-106 collagen type XX alpha 1 chain Homo sapiens 39-42 33141121-8 2020 The catechol-encoded CLP also acted as a "smart material" by mimicking long-acting cellular growth factor showing enhanced cell-material interactions by promoting cell proliferation and angiogenesis. catechol 4-12 collagen type XX alpha 1 chain Homo sapiens 21-24 33225336-1 2020 The interaction potential energy surfaces (IPESs) of four alkaline metal cations (Na+, K+, Rb+ and Cs+) complexed with phenol and catechol were explored by accurate ab initio calculations to investigate the interplay of different noncovalent interactions and their behavior along the alkali metal series and upon -OH substitution. catechol 130-138 citrate synthase Homo sapiens 99-101 33348622-2 2020 Generally, the enzyme polyphenol oxidase (PPO) catalyzes two different reactions in the presence of molecular oxygen: the hydroxylation of monophenols to ortho-diphenol and the oxidation of o-diphenol to o-quinone. catechol 154-168 protoporphyrinogen oxidase Homo sapiens 22-40 33348622-2 2020 Generally, the enzyme polyphenol oxidase (PPO) catalyzes two different reactions in the presence of molecular oxygen: the hydroxylation of monophenols to ortho-diphenol and the oxidation of o-diphenol to o-quinone. catechol 154-168 protoporphyrinogen oxidase Homo sapiens 42-45 33348622-2 2020 Generally, the enzyme polyphenol oxidase (PPO) catalyzes two different reactions in the presence of molecular oxygen: the hydroxylation of monophenols to ortho-diphenol and the oxidation of o-diphenol to o-quinone. catechol 158-168 protoporphyrinogen oxidase Homo sapiens 22-40 33348622-2 2020 Generally, the enzyme polyphenol oxidase (PPO) catalyzes two different reactions in the presence of molecular oxygen: the hydroxylation of monophenols to ortho-diphenol and the oxidation of o-diphenol to o-quinone. catechol 158-168 protoporphyrinogen oxidase Homo sapiens 42-45 32869889-5 2020 The preferred substrates for mPPO and the two sPPOs were catechol and chlorogenic acid, respectively. catechol 57-65 protoporphyrinogen oxidase Mus musculus 29-33 32866920-2 2020 COMT expression is directedly associated with various mental diseases and cancers due to its essential role in catalyzing metabolic inactivation of endogenous catecholamines and catechol estrogens. catechol 159-167 catechol-O-methyltransferase Homo sapiens 0-4 32738620-0 2020 Molecular modeling and in vitro study on pyrocatechol as potential pharmacophore of CD151 inhibitor. catechol 41-53 CD151 molecule (Raph blood group) Homo sapiens 84-89 32738620-8 2020 Molecular docking study identified pyrocatechol (PCL) and 5-fluorouracil (FU) as potential leads of CD151-LEL. catechol 35-47 CD151 molecule (Raph blood group) Homo sapiens 100-105 32738620-14 2020 This study suggests the further assessment of pyrocatechol as a potential lead of CD151 in breast cancer at the molecular level. catechol 46-58 CD151 molecule (Raph blood group) Homo sapiens 82-87 32100171-1 2020 OBJECTIVES: Catechol-O-methyl transferase (COMT), a catechol-dependent enzyme, plays pivotal role in the development of pain. catechol 52-60 catechol-O-methyltransferase Homo sapiens 12-41 33035385-4 2020 RNase A bioreversibly modified with phenylboronic acid groups via a ROS-cleavable carbamate linker is incorporated into the triblock copolymer nanoparticles with high efficiency through a pH-reversible phenylboronic acid-catechol linkage. catechol 221-229 ribonuclease A family member 1, pancreatic Homo sapiens 0-7 32394320-3 2020 The optimum pH of the immobilized tyrosinase (tyrosinase-ATO-TF) was 6.0, and the optimum temperature was found to be 30 C. In the presence of catechol substrate of immobilized enzymes, Km and Vmax values were determined as 0.34 mM and 312.5 U/cm2 min, respectively. catechol 144-152 tyrosinase Homo sapiens 34-44 32504915-2 2020 To release the chemical formation mechanism of the dark spots formed on FWNS, the reconstituted FWNS and PPO-catechol reaction systems were prepared. catechol 109-117 protoporphyrinogen oxidase Homo sapiens 105-108 32100171-1 2020 OBJECTIVES: Catechol-O-methyl transferase (COMT), a catechol-dependent enzyme, plays pivotal role in the development of pain. catechol 52-60 catechol-O-methyltransferase Homo sapiens 43-47 32492152-1 2020 Human catechol-O-methyltransferase (COMT), a key enzyme related to neurotransmitter metabolism, catalyzes a methyl transfer from S-adenosylmethionine (SAM) to catechol. catechol 6-14 catechol-O-methyltransferase Homo sapiens 36-40 32806111-0 2020 Catechol Dyes-Tyrosinase System for Colorimetric Determination and Discrimination of Dithiocarbamate Pesticides. catechol 0-8 tyrosinase Homo sapiens 14-24 32942764-0 2020 Oxidative Oligomerization of DBL Catechol, a potential Cytotoxic Compound for Melanocytes, Reveals the Occurrence of Novel Ionic Diels-Alder Type Additions. catechol 33-41 MCF.2 cell line derived transforming sequence Homo sapiens 29-32 32942764-5 2020 Earlier studies indicate that RK is initially oxidized to RK quinone by tyrosinase and subsequently converted to a side chain desaturated catechol called 3,4-dihydroxybenzalacetone (DBL catechol). catechol 138-146 MCF.2 cell line derived transforming sequence Homo sapiens 182-185 32942764-5 2020 Earlier studies indicate that RK is initially oxidized to RK quinone by tyrosinase and subsequently converted to a side chain desaturated catechol called 3,4-dihydroxybenzalacetone (DBL catechol). catechol 186-194 MCF.2 cell line derived transforming sequence Homo sapiens 182-185 32942764-6 2020 In the present study, we report the oxidation chemistry of DBL catechol. catechol 63-71 MCF.2 cell line derived transforming sequence Homo sapiens 59-62 32942764-7 2020 Using UV-visible spectroscopic studies and liquid chromatography mass spectrometry, we have examined the reaction of DBL catechol with tyrosinase and sodium periodate. catechol 121-129 MCF.2 cell line derived transforming sequence Homo sapiens 117-120 32732028-0 2020 A voltammetry biosensor based on self-assembled layers of a heteroleptic tris(phthalocyaninato) europium triple-decker complex and tyrosinase for catechol detection. catechol 146-154 tyrosinase Homo sapiens 131-141 32806111-3 2020 Tyrosinase can facilitate oxidation of the catechol dyes, altering color and absorbance spectra of the dyes. catechol 43-51 tyrosinase Homo sapiens 0-10 32806111-4 2020 DTCs can alter the absorbance spectra of the catechol dyes-tyrosinase system due to their inhibitory effects on tyrosinase. catechol 45-53 tyrosinase Homo sapiens 59-69 32806111-4 2020 DTCs can alter the absorbance spectra of the catechol dyes-tyrosinase system due to their inhibitory effects on tyrosinase. catechol 45-53 tyrosinase Homo sapiens 112-122 32478527-0 2020 Catechol Functionalized Elastin-like Polypeptides as Tissue Adhesives. catechol 0-8 elastin Mus musculus 24-31 32447731-8 2020 PPO and a chromophore reagent (3-methyl-2-benzothiazolinone hydrazine) generated a range of color in the presence of phenolic compounds (catechol, phenol, p-cresol, 4-methyl catechol) within 15 min, and limit of detection was found to be 0.5 muM. catechol 137-145 catechol oxidase B, chloroplastic Solanum tuberosum 0-3 32784502-1 2020 An efficient asymmetric synthesis of GlaxoSmithKline"s potent PDE4 inhibitor was accomplished in eight steps from a catechol-derived nitroalkene. catechol 116-124 phosphodiesterase 4A Homo sapiens 62-66 32409070-5 2020 TN- and CHI-based PEMs adsorb similar amounts of albumin, whereas fibrinogen adsorption was more pronounced on TN-based PEMs, due to strong association with catechol groups. catechol 157-165 fibrinogen beta chain Homo sapiens 66-76 32290315-6 2020 Electrochemical responses towards catechol showed that the LbL composites efficiently improved the electron transfer path between Tyr or Lac and the electrode surface, producing an increase in the intensity over the response in the absence of the LbL platform. catechol 34-42 tyrosinase Homo sapiens 130-133 32236879-1 2020 Catechol-O-methyltransferase (COMT) enzyme performs transfer of methyl group to endogenous and exogenous catechol substrates. catechol 105-113 catechol-O-methyltransferase Homo sapiens 0-28 32236879-1 2020 Catechol-O-methyltransferase (COMT) enzyme performs transfer of methyl group to endogenous and exogenous catechol substrates. catechol 105-113 catechol-O-methyltransferase Homo sapiens 30-34 32376896-0 2020 Catechol inhibits epidermal growth factor-induced epithelial-to-mesenchymal transition and stem cell-like properties in hepatocellular carcinoma cells. catechol 0-8 epidermal growth factor Homo sapiens 18-41 32376896-5 2020 The present study showed that catechol suppressed not only the morphological changes to the mesenchymal phenotype of epithelial HCC cells, but also the reduction of E-cadherin and the increment of Vimentin, which are typical hallmark of EMT. catechol 30-38 cadherin 1 Homo sapiens 165-175 32376896-5 2020 The present study showed that catechol suppressed not only the morphological changes to the mesenchymal phenotype of epithelial HCC cells, but also the reduction of E-cadherin and the increment of Vimentin, which are typical hallmark of EMT. catechol 30-38 vimentin Homo sapiens 197-205 32376896-6 2020 In addition, catechol suppressed EMT-related steps such as migration, invasion, anoikis resistance acquisition, and stem cell-like characterization through the EGFR-AKT-ERK signaling pathway during liver cancer metastasis. catechol 13-21 epidermal growth factor receptor Homo sapiens 160-164 32376896-6 2020 In addition, catechol suppressed EMT-related steps such as migration, invasion, anoikis resistance acquisition, and stem cell-like characterization through the EGFR-AKT-ERK signaling pathway during liver cancer metastasis. catechol 13-21 AKT serine/threonine kinase 1 Homo sapiens 165-168 32376896-6 2020 In addition, catechol suppressed EMT-related steps such as migration, invasion, anoikis resistance acquisition, and stem cell-like characterization through the EGFR-AKT-ERK signaling pathway during liver cancer metastasis. catechol 13-21 mitogen-activated protein kinase 1 Homo sapiens 169-172 32097726-8 2020 IC50 values were determined to be 0.018 and 0.029 mM for potato PPO with curcumin and quercetin inhibitors with catechol as a substrate, respectively. catechol 112-120 catechol oxidase B, chloroplastic Solanum tuberosum 64-67 31782480-0 2020 Functionalized tungsten disulfide nanotubes for dopamine and catechol detection in a tyrosinase-based amperometric biosensor design. catechol 61-69 tyrosinase Homo sapiens 85-95 31782480-1 2020 WS2 nanotubes functionalized with carboxylic acid functions (WS2-COOH) were used for improved immobilization of the enzyme tyrosinase in order to form an electrochemical biosensor towards catechol and dopamine. catechol 188-196 tyrosinase Homo sapiens 123-133 32054966-0 2020 Pyrocatechol, a component of coffee, suppresses LPS-induced inflammatory responses by inhibiting NF-kappaB and activating Nrf2. catechol 0-12 nuclear factor, erythroid derived 2, like 2 Mus musculus 122-126 32435383-3 2020 On the basis of our previous research, nordihydroguaiaretic acid 1 acts as a NC inhibitor showing moderate antiviral activity and suboptimal drug-like properties due to the presence of the catechol moieties. catechol 189-197 mediator complex subunit 25 Homo sapiens 60-66 32101397-0 2020 Partitioning of Catechol Derivatives in Lipid Membranes: Implications for Substrate Specificity to Catechol-O-methyltransferase. catechol 16-24 catechol-O-methyltransferase Homo sapiens 99-127 32133417-2 2020 Sesamin is converted to the catechol metabolite, SC1 [(7alpha,7"alpha,8alpha,8"alpha)-3",4"-methylenedioxy-7,9":7",9-diepoxylignane-3,4-diol] with anti-inflammatory effects after oral administration. catechol 28-36 spinal cord QTL 1 Mus musculus 49-52 31924001-6 2020 The sensor responded to a broad dynamic range of catechol concentrations from 1 muM to 100 muM with sensitivity of 51.29 muM-1 cm-2 and limit of detection of 0.52 muM which are better than previously reported catechol sensors. catechol 49-57 PWWP domain containing 3A, DNA repair factor Homo sapiens 121-131 31924001-6 2020 The sensor responded to a broad dynamic range of catechol concentrations from 1 muM to 100 muM with sensitivity of 51.29 muM-1 cm-2 and limit of detection of 0.52 muM which are better than previously reported catechol sensors. catechol 209-217 PWWP domain containing 3A, DNA repair factor Homo sapiens 121-131 32054966-6 2020 A treatment with 5%(v/v) coffee extract and more than 2.5 muM pyrocatechol inhibited the LPS-induced activation of NF-kappaB and also significantly activated Nrf2, which acts as a negative regulator in LPS-induced inflammation. catechol 62-74 nuclear factor, erythroid derived 2, like 2 Mus musculus 158-162 31816461-5 2020 Because of the synergistic effect of MoS2 nanosheets and gold nanoparticles, the laccase based bioelectrode exhibited a linear response to catechol from 2 to 2000 muM with a detection limit of 2 muM (S/N = 3), as well as good selectivity, stability, repeatability, and reproducibility. catechol 139-147 latexin Homo sapiens 163-166 31816461-5 2020 Because of the synergistic effect of MoS2 nanosheets and gold nanoparticles, the laccase based bioelectrode exhibited a linear response to catechol from 2 to 2000 muM with a detection limit of 2 muM (S/N = 3), as well as good selectivity, stability, repeatability, and reproducibility. catechol 139-147 latexin Homo sapiens 195-198 31442058-0 2019 Catechol-Functionalized Chitosan: Optimized Preparation Method and Its Interaction with Mucin. catechol 0-8 LOC100508689 Homo sapiens 88-93 31708229-7 2020 Apart from catechol modification, some non-catechol based potent COMT inhibitors are also discussed. catechol 43-51 catechol-O-methyltransferase Homo sapiens 65-69 31744341-2 2020 Catechol-O-methyltransferase (COMT, E.C 2.1.1.6) inactivates dopamine and other substrates bearing catechol through the methylation of a hydroxyl group. catechol 99-107 catechol-O-methyltransferase Homo sapiens 0-28 31744341-2 2020 Catechol-O-methyltransferase (COMT, E.C 2.1.1.6) inactivates dopamine and other substrates bearing catechol through the methylation of a hydroxyl group. catechol 99-107 catechol-O-methyltransferase Homo sapiens 30-34 31267354-6 2020 These results on the inhibitory activity of kukoamines A and B on Abeta and hIAPP indicate that the catechol moiety is essential for inhibition of amyloid aggregation. catechol 100-108 amyloid beta precursor protein Homo sapiens 66-71 31267354-6 2020 These results on the inhibitory activity of kukoamines A and B on Abeta and hIAPP indicate that the catechol moiety is essential for inhibition of amyloid aggregation. catechol 100-108 islet amyloid polypeptide Homo sapiens 76-81 31586564-1 2020 Catechol-O-methyltransferase (COMT) enzyme has a major role in the adjustment of catechol-dependent functions, for example, cognition, cardiac function, and pain processing. catechol 81-89 catechol-O-methyltransferase Homo sapiens 0-28 31586564-1 2020 Catechol-O-methyltransferase (COMT) enzyme has a major role in the adjustment of catechol-dependent functions, for example, cognition, cardiac function, and pain processing. catechol 81-89 catechol-O-methyltransferase Homo sapiens 30-34 31859491-0 2020 Dual-Readout Tyrosinase Activity Assay Facilitated by a Chromo-Fluorogenic Reaction between Catechols and Naphthoresorcin. catechol 92-101 tyrosinase Homo sapiens 13-23 31859491-5 2020 Inspired by the tyrosinase-catalyzed hydroxylation of monophenols to catechols, the tyrosinase-enabled chromo-fluorogenic reaction was verified by using monophenol (typically tyrosol) as the substrate. catechol 69-78 tyrosinase Homo sapiens 16-26 31859491-5 2020 Inspired by the tyrosinase-catalyzed hydroxylation of monophenols to catechols, the tyrosinase-enabled chromo-fluorogenic reaction was verified by using monophenol (typically tyrosol) as the substrate. catechol 69-78 tyrosinase Homo sapiens 84-94 31763728-4 2020 Assembly is achieved by in situ conversion of monophenols into catechols via tyrosinase, where films form on surfaces via covalent and coordination cross-linking. catechol 63-72 tyrosinase Homo sapiens 77-87 33132271-10 2020 Pyrocatechol, a component of roasted coffee, also reduced Abeta production and exhibits anti-inflammatory effects by a similar mechanism as coffee. catechol 0-12 amyloid beta (A4) precursor protein Mus musculus 58-63 31794208-0 2019 Targeting Endogenous Adduction Level of Serum Albumin by Parallel Reaction Monitoring via Standard Additions and Intact Protein Measurement: Biological Dosimetry of Catechol Estrogens. catechol 165-173 albumin Homo sapiens 46-53 31746824-5 2019 Herein, P-1 Pdots with the strongest ECL signal were successfully used as ECL biosensors for the detection of catechol, epinephrine and dopamine with detection limits of 1, 7 and 3 nM, respectively. catechol 110-118 crystallin gamma F, pseudogene Homo sapiens 8-11 31493422-1 2019 Cytochrome P450 1B1 (CYP1B1) is a key enzyme that catalyzes the metabolism of 17beta-estradiol (E2) into catechol estrogens, such as 2-hydroxyestradiol (2-OHE2) and 4-hydroxyestradiol (4-OHE2). catechol 105-113 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 31493422-1 2019 Cytochrome P450 1B1 (CYP1B1) is a key enzyme that catalyzes the metabolism of 17beta-estradiol (E2) into catechol estrogens, such as 2-hydroxyestradiol (2-OHE2) and 4-hydroxyestradiol (4-OHE2). catechol 105-113 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 31294497-2 2019 In this work, to design lymphoseek-inspired vaccine possessing the abilities of promoting vaccine internalization and enhancing CD8+ T-cell responses, a simple multicomponent strategy is successfully utilized to fabricate lymph node and dendritic cell dual-targeting glycoadjuvant@AuNPs in one pot, where three different components, catechol-containing glycopolymer, HAuCl4 , and amine-terminal CpG (CpG-NH2 ) can react in a single step to generate target adjuvant. catechol 333-341 CD8a molecule Homo sapiens 128-131 31546368-8 2019 Catechol-containing hydrogels present high tissue adhesion strength under wet conditions, support growth, migration and proliferation of hBMSCs, protect cells against oxidative stress damage induce by ROS, and promote down-regulation of the pro-inflammatory cytokine IL-1beta. catechol 0-8 interleukin 1 alpha Homo sapiens 267-275 31771973-5 2019 Two positive fosmid clones, SD3 and RW1, suggested the presence of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC-SD3) and catechol 2,3-dioxygenase (C23O-RW1), respectively. catechol 120-128 transmembrane protein 131 Homo sapiens 36-39 31409458-5 2019 Excellent predictions were obtained for the determination of hydroquinone and catechol in the direct analysis of spiked tap water samples with EIS and complex numbers-PLS. catechol 78-86 nuclear RNA export factor 1 Homo sapiens 120-123 31686218-0 2019 Amperometric sensing of catechol by using a nanocomposite prepared from Ag/Ag2O nanoparticles and N,S-doped carbon quantum dots. catechol 24-32 anterior gradient 2, protein disulphide isomerase family member Homo sapiens 75-78 31359186-0 2019 Immobilization of tyrosinase on Fe3o4@Au core-shell nanoparticles as bio-probe for detection of dopamine, phenol and catechol. catechol 117-125 tyrosinase Homo sapiens 18-28 31359186-1 2019 An optical bio-probe based on the immobilized tyrosinase on the surface of Fe3O4@Au was described for the detection of dopamine, phenol and catechol. catechol 140-148 tyrosinase Homo sapiens 46-56 31420727-0 2019 Correction to: Immobilization of tyrosinase on Fe3o4@Au core-shell nanoparticles as bio-probe for detection of dopamine, phenol and catechol. catechol 132-140 tyrosinase Homo sapiens 33-43 31532644-1 2019 Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. catechol 24-32 dopamine receptor D1 Homo sapiens 67-87 31447554-2 2019 Methods: Inspired by the excellent adhesion properties of mussel protein, we prepared novel catechol-grafted chitosan alginate/barium sulfate microcapsules (Cat-CA/BS MCs) with mucoadhesive properties and computed tomography (CT) imaging function for gastric drug delivery. catechol 92-100 catalase Homo sapiens 157-160 31523478-7 2019 Catechol 2,3 dioxygenase is almost twice as dense or compact as beta-galactosidase and thus it is far easier for salts to penetrate and rescue inactive beta-galactosidase proteins. catechol 0-8 galactosidase beta 1 Homo sapiens 152-170 31339696-0 2019 Identification of Catechol-Type Diphenylbutadiene as a Tyrosinase-Activated Pro-oxidative Chemosensitizer against Melanoma A375 Cells via Glutathione S-Transferase Inhibition. catechol 18-26 tyrosinase Homo sapiens 55-65 31339696-0 2019 Identification of Catechol-Type Diphenylbutadiene as a Tyrosinase-Activated Pro-oxidative Chemosensitizer against Melanoma A375 Cells via Glutathione S-Transferase Inhibition. catechol 18-26 glutathione S-transferase kappa 1 Homo sapiens 138-163 31447554-4 2019 Next, catechol-grafted chitosan as the mucoadhesive moiety was coated on the surface of Cat-CA/BS MCs by polyelectrolyte molecule self-assembly. catechol 6-14 catalase Homo sapiens 88-91 30916930-1 2019 Tyrosinase (TYR) which can catalyze the oxidation of catechol is recognized as a significant biomarker of melanocytic lesions, thus developing powerful methods for the determination of TYR activity is highly desirable for the early diagnosis of melanin-related diseases, including melanoma. catechol 53-61 tyrosinase Homo sapiens 12-15 33405568-7 2019 Distinct from a previous approach to functionalize silk directly with catechol groups, this work investigated in situ generation of catechol on silk fibroin by enzymatically modifying phenolic side chains, where it was found that this enzymatic approach led to conjugates with higher degrees of catechol functionalization and aqueous solubility. catechol 132-140 fibroin light chain Bombyx mori 149-156 33405568-7 2019 Distinct from a previous approach to functionalize silk directly with catechol groups, this work investigated in situ generation of catechol on silk fibroin by enzymatically modifying phenolic side chains, where it was found that this enzymatic approach led to conjugates with higher degrees of catechol functionalization and aqueous solubility. catechol 132-140 fibroin light chain Bombyx mori 149-156 33405568-8 2019 Silk fibroin was functionalized with tyramine to enrich the protein"s phenolic side chains, which were subsequently oxidized into catechol groups using mushroom tyrosinase (MT). catechol 130-138 fibroin light chain Bombyx mori 5-12 33405568-13 2019 Phenolic functionalization and oxidative cross-linking of silk fibroin was found to afford a new route to water-soluble, catechol-functionalized polymers, which were found to display excellent adhesion to mucosal tissue and whose secondary structure provides an additional mode to control strength and swelling of adhesive gels. catechol 121-129 fibroin light chain Bombyx mori 63-70 31005742-4 2019 Therefore, the coating can anchor bone morphogenic protein-2 (BMP2) to the HA scaffold via catechol chemistry under a mild condition so as to protect the bioactivity of BMP2. catechol 91-99 bone morphogenetic protein 2 Homo sapiens 34-60 31005742-4 2019 Therefore, the coating can anchor bone morphogenic protein-2 (BMP2) to the HA scaffold via catechol chemistry under a mild condition so as to protect the bioactivity of BMP2. catechol 91-99 bone morphogenetic protein 2 Homo sapiens 62-66 31005742-4 2019 Therefore, the coating can anchor bone morphogenic protein-2 (BMP2) to the HA scaffold via catechol chemistry under a mild condition so as to protect the bioactivity of BMP2. catechol 91-99 bone morphogenetic protein 2 Homo sapiens 169-173 30916930-1 2019 Tyrosinase (TYR) which can catalyze the oxidation of catechol is recognized as a significant biomarker of melanocytic lesions, thus developing powerful methods for the determination of TYR activity is highly desirable for the early diagnosis of melanin-related diseases, including melanoma. catechol 53-61 tyrosinase Homo sapiens 0-10 31108985-1 2019 A copper sulfide nanoflakes-decorated carbon nanofragments-modified glassy carbon electrode (CuS-CNF/GCE) was fabricated for the electrocatalytic differentiation and determination of hydroquinone (HQ) and catechol (CC). catechol 205-213 glycine decarboxylase Homo sapiens 93-104 30703421-0 2019 Catalytic mechanism for the conversion of salicylate into catechol by the flavin-dependent monooxygenase salicylate hydroxylase. catechol 58-66 salicylate hydroxylase Pseudomonas putida 105-127 30703421-1 2019 Salicylate hydroxylase (NahG) is a flavin-dependent monooxygenase that catalyzes the decarboxylative hydroxylation of salicylate into catechol in the naphthalene degradation pathway in Pseudomonas putida G7. catechol 134-142 salicylate hydroxylase Pseudomonas putida 0-22 31017164-5 2019 Furthermore, N-Co-Fe-HCS as an electrochemical sensor exhibited excellent simultaneous qualitative and quantitative determination performance for catechol (CC) and hydroquinone (HQ). catechol 146-154 holocarboxylase synthetase Homo sapiens 21-24 31080692-4 2019 Here we establish that sinefungin, a fungal-derived inhibitor of SAM-dependent enzymes that possess transition state-like charge on the transferring group, can be used as a transition state analog of COMT when combined with a catechol. catechol 226-234 catechol-O-methyltransferase Homo sapiens 200-204 31242734-5 2019 We find that intermolecular hydrogen bonding to the free O-H group in catechol increases its first excited singlet state (S1) lifetime by 2 orders of magnitude (i.e., ~ 16 to 1410 ps), and that O-H bond dissociation is prevented because Et2O is a poor hydrogen atom acceptor. catechol 70-78 endothelin 2 Homo sapiens 237-240 30935952-1 2019 Catechol-containing polyphenols present in coffee and tea, while serving as excellent substrates for catechol-O-methyltransferase (COMT)-catalyzed O-methylation, can also operate as COMT inhibitors. catechol 0-8 catechol-O-methyltransferase Homo sapiens 131-135 30935952-1 2019 Catechol-containing polyphenols present in coffee and tea, while serving as excellent substrates for catechol-O-methyltransferase (COMT)-catalyzed O-methylation, can also operate as COMT inhibitors. catechol 0-8 catechol-O-methyltransferase Homo sapiens 182-186 30935952-4 2019 Oleacein could be superimposed onto the catechol-binding site of COMT, maintaining the interactions with the atomic positions involved in methyl transfer from the S-adenosyl-L-methionine cofactor. catechol 40-48 catechol-O-methyltransferase Homo sapiens 65-69 30916930-1 2019 Tyrosinase (TYR) which can catalyze the oxidation of catechol is recognized as a significant biomarker of melanocytic lesions, thus developing powerful methods for the determination of TYR activity is highly desirable for the early diagnosis of melanin-related diseases, including melanoma. catechol 53-61 tyrosinase Homo sapiens 185-188 30907592-8 2019 Catechol structure in the B-ring attenuated the activate action of SR-BI expression. catechol 0-8 scavenger receptor class B member 1 Homo sapiens 67-72 31028498-0 2019 Colorimetric tyrosinase assay based on catechol inhibition of the oxidase-mimicking activity of chitosan-stabilized platinum nanoparticles. catechol 39-47 tyrosinase Homo sapiens 13-23 31028498-3 2019 Tyrosinase (TYRase) catalyzes the oxidation of catechol, thus restoring the activity of oxidase-mimicking Chit-PtNPs. catechol 47-55 tyrosinase Homo sapiens 0-10 31028498-3 2019 Tyrosinase (TYRase) catalyzes the oxidation of catechol, thus restoring the activity of oxidase-mimicking Chit-PtNPs. catechol 47-55 tyrosinase Homo sapiens 12-18 31028498-4 2019 By combining the Chit-PtNP, catechol, and TYRase interactions with the oxidation of TMB to form a yellow diamine (maximal absorbance at 450 nm), a colorimetric analytical method was developed for TYRase determination and inhibitor screening. catechol 28-36 tyrosinase Homo sapiens 196-202 31028498-8 2019 It is based on the fact that catechol can inhibit the oxidase-like activity of chitosan-stabilized platinum nanoparticles (Ch-PtNPs) by competing with the substrate for the active sites and TYRase can catalyze the oxidation of catechol. catechol 29-37 tyrosinase Homo sapiens 190-196 31028498-8 2019 It is based on the fact that catechol can inhibit the oxidase-like activity of chitosan-stabilized platinum nanoparticles (Ch-PtNPs) by competing with the substrate for the active sites and TYRase can catalyze the oxidation of catechol. catechol 227-235 tyrosinase Homo sapiens 190-196 30672618-4 2019 RESULTS: The Ole-cis-DAP conjugate (i.e., C25 H36 N2 O13 PtII ) features two cis-ammine non-leaving ligands and a bidentate catechol ligand moiety belonging to Ole; the coordination of the central Pt(II) is square-planar with non-equivalent bond angles compared with the ideal arrangement of 90 . catechol 124-132 death associated protein Homo sapiens 21-24 30875219-0 2019 Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists. catechol 82-90 dopamine receptor D1 Homo sapiens 91-111 30875219-3 2019 A class of novel non-catechol G protein-biased agonists of the dopamine D1 receptor (D1R) was recently disclosed. catechol 21-29 dopamine receptor D1 Homo sapiens 63-83 30587572-0 2019 Catechol estrogens stimulate insulin secretion in pancreatic beta-cells via activation of the transient receptor potential A1 (TRPA1) channel. catechol 0-8 transient receptor potential cation channel subfamily A member 1 Homo sapiens 94-125 30550954-5 2019 Early results from our group indicated that 4-nerolidylcatechol (4-NC), a catechol compound extracted from Pothomorphe umbellata, induces DNA damage, ROS production, increased p53 expression culminating in apoptosis in melanoma but with no data regarding the 4-NC effects in cells resistant to BRAFi or MEKi. catechol 55-63 tumor protein p53 Homo sapiens 176-179 30472612-9 2019 In addition, TOC had direct positive effects on catechol dioxygenation and nidA. catechol 48-56 rhomboid 5 homolog 2 Homo sapiens 13-16 30735747-7 2019 PG and PC alter the DDR and may promote ATR-Chk1 and ATM-Chk2 pathways, respectively. catechol 7-9 ATR serine/threonine kinase Homo sapiens 40-43 30735747-7 2019 PG and PC alter the DDR and may promote ATR-Chk1 and ATM-Chk2 pathways, respectively. catechol 7-9 checkpoint kinase 1 Homo sapiens 44-48 30735747-7 2019 PG and PC alter the DDR and may promote ATR-Chk1 and ATM-Chk2 pathways, respectively. catechol 7-9 ATM serine/threonine kinase Homo sapiens 53-56 30735747-7 2019 PG and PC alter the DDR and may promote ATR-Chk1 and ATM-Chk2 pathways, respectively. catechol 7-9 checkpoint kinase 2 Homo sapiens 57-61 30587572-0 2019 Catechol estrogens stimulate insulin secretion in pancreatic beta-cells via activation of the transient receptor potential A1 (TRPA1) channel. catechol 0-8 transient receptor potential cation channel subfamily A member 1 Homo sapiens 127-132 30587572-6 2019 In insulin-secreting cells, catechol estrogens produced rapid activation of calcium influx and elevation in cytosolic free calcium. catechol 28-36 insulin Homo sapiens 3-10 30587572-7 2019 Catechol estrogens also generated sustained elevations in cytosolic free calcium and evoked inward ion current in HEK293 cells expressing the transient receptor potential A1 (TRPA1) cation channel. catechol 0-8 transient receptor potential cation channel subfamily A member 1 Homo sapiens 142-173 30587572-7 2019 Catechol estrogens also generated sustained elevations in cytosolic free calcium and evoked inward ion current in HEK293 cells expressing the transient receptor potential A1 (TRPA1) cation channel. catechol 0-8 transient receptor potential cation channel subfamily A member 1 Homo sapiens 175-180 32627373-4 2019 The RGD peptide can interfere with integrin alphav beta3 to affect the cytoskeletal organization and functions of osteoclasts and subsequently inhibit osteoclast hyperactivation and osteoclastogenesis in vitro and in vivo, while the catechol groups could easily adhere to the TiO2 layer of the Ti implant via Ti-catechol coordination. catechol 233-241 integrin subunit alpha V Homo sapiens 35-56 32627373-4 2019 The RGD peptide can interfere with integrin alphav beta3 to affect the cytoskeletal organization and functions of osteoclasts and subsequently inhibit osteoclast hyperactivation and osteoclastogenesis in vitro and in vivo, while the catechol groups could easily adhere to the TiO2 layer of the Ti implant via Ti-catechol coordination. catechol 312-320 integrin subunit alpha V Homo sapiens 35-56 30525590-4 2019 Initial attempts to identify agonists yielded catechol derivatives, mimicking dopamine, with suboptimal DMPK parameters and low selectivity over the D5 subtype. catechol 46-54 DM1 protein kinase Homo sapiens 104-108 30272964-4 2018 An X-ray cocrystal structure of compound 21 in the S-COMT active site shows chelation of the active site magnesium similar to catechol-based inhibitors. catechol 126-134 catechol-O-methyltransferase Homo sapiens 53-57 32254937-4 2018 The resulting phenol was used as a substrate of Tyr, which was catalyzed to catechol and subsequently to o-quinone. catechol 76-84 tyrosinase Homo sapiens 48-51 30575781-5 2018 To accomplish the conversion of PCA to catechol (CA), a step that is absent in Corynebacterium, a codon-optimized heterologous PCA decarboxylase gene was expressed as a single operon under the strong promoter in a aroE-pcaG/H-catB triple knock-out Corynebacterium strain. catechol 39-47 cathepsin B Homo sapiens 226-230 30488065-7 2018 The hydrophilic catechol groups and the long hydrophobic alkyl groups of urushiol allowed MSN@U to self-assemble at the blood/air interface. catechol 16-24 moesin Rattus norvegicus 90-93 30218069-1 2018 Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the O-methylation, and thereby the inactivation, of catechol-containing molecules. catechol 116-124 catechol-O-methyltransferase Homo sapiens 0-28 30218069-1 2018 Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the O-methylation, and thereby the inactivation, of catechol-containing molecules. catechol 116-124 catechol-O-methyltransferase Homo sapiens 30-34 30168237-1 2018 The enzyme catechol-o-methyltransferase (COMT) is responsible for inactivation of catechol estrogens, which are well-recognized carcinogenic metabolites. catechol 11-19 catechol-O-methyltransferase Canis lupus familiaris 41-45 29964299-0 2018 Catechol derived from aronia juice through lactic acid bacteria fermentation inhibits breast cancer stem cell formation via modulation Stat3/IL-6 signaling pathway. catechol 0-8 signal transducer and activator of transcription 3 Homo sapiens 135-140 29964299-0 2018 Catechol derived from aronia juice through lactic acid bacteria fermentation inhibits breast cancer stem cell formation via modulation Stat3/IL-6 signaling pathway. catechol 0-8 interleukin 6 Homo sapiens 141-145 29964299-9 2018 Catechol preferentially reduced mRNA transcripts and protein levels of Stat3 and did not induce c-Myc degradation. catechol 0-8 signal transducer and activator of transcription 3 Homo sapiens 71-76 29964299-10 2018 These findings support the novel utilization of catechol for breast cancer therapy via the Stat3/IL-6 signaling pathway. catechol 48-56 signal transducer and activator of transcription 3 Homo sapiens 91-96 29964299-10 2018 These findings support the novel utilization of catechol for breast cancer therapy via the Stat3/IL-6 signaling pathway. catechol 48-56 interleukin 6 Homo sapiens 97-101 29964299-12 2018 Catechol inhibited Stat3 signaling by reducing Stat3 expression and secreted IL-6, a CSC survival factor. catechol 0-8 signal transducer and activator of transcription 3 Homo sapiens 19-24 29964299-12 2018 Catechol inhibited Stat3 signaling by reducing Stat3 expression and secreted IL-6, a CSC survival factor. catechol 0-8 signal transducer and activator of transcription 3 Homo sapiens 47-52 29964299-12 2018 Catechol inhibited Stat3 signaling by reducing Stat3 expression and secreted IL-6, a CSC survival factor. catechol 0-8 interleukin 6 Homo sapiens 77-81 29964299-13 2018 These findings support the novel utilization of catechol for breast cancer therapy via Stat3/IL-6 signaling. catechol 48-56 signal transducer and activator of transcription 3 Homo sapiens 87-92 29964299-13 2018 These findings support the novel utilization of catechol for breast cancer therapy via Stat3/IL-6 signaling. catechol 48-56 interleukin 6 Homo sapiens 93-97 30144352-6 2018 Pyrocatechol, a strong antioxidant known as catechol or 1,2-dihydroxybenzene, produced from chlorogenic acid during roasting, also reduces BACE1 expression by activation of proteasomal activity. catechol 0-12 beta-secretase 1 Homo sapiens 139-144 30209938-2 2018 The aim of this study was to develop surface-enhanced Raman scattering (SERS) approach for accurate determination of PPO activity in fruit and vegetables using the reduction in SERS intensity of catechol in reaction medium. catechol 195-203 catechol oxidase B, chloroplastic Solanum tuberosum 117-120 30209938-3 2018 Within a certain catechol concentration, when a purified PPO solution was analyzed, the reduction in SERS intensity (Delta I) was linear to PPO activity ( Ec) in a wide range of 500-50 000 U/L, and a linear regression equation of log Delta I/Delta t = 0.6223 log Ec + 0.8072, with a correlation coefficient of 0.9689 and a limit of detection of 224.65 U/L, was obtained. catechol 17-25 catechol oxidase B, chloroplastic Solanum tuberosum 57-60 30209938-3 2018 Within a certain catechol concentration, when a purified PPO solution was analyzed, the reduction in SERS intensity (Delta I) was linear to PPO activity ( Ec) in a wide range of 500-50 000 U/L, and a linear regression equation of log Delta I/Delta t = 0.6223 log Ec + 0.8072, with a correlation coefficient of 0.9689 and a limit of detection of 224.65 U/L, was obtained. catechol 17-25 catechol oxidase B, chloroplastic Solanum tuberosum 140-143 30304773-9 2018 We also discuss on the relationship between catechol-O-methyltransferase (COMT), an enzyme that metabolizes catechol, and AMPK during pregnancy. catechol 44-52 catechol-O-methyltransferase Mus musculus 74-78 30144352-6 2018 Pyrocatechol, a strong antioxidant known as catechol or 1,2-dihydroxybenzene, produced from chlorogenic acid during roasting, also reduces BACE1 expression by activation of proteasomal activity. catechol 4-12 beta-secretase 1 Homo sapiens 139-144 30144352-6 2018 Pyrocatechol, a strong antioxidant known as catechol or 1,2-dihydroxybenzene, produced from chlorogenic acid during roasting, also reduces BACE1 expression by activation of proteasomal activity. catechol 56-76 beta-secretase 1 Homo sapiens 139-144 30144352-7 2018 Furthermore, pyrocatechol reduces Abeta production in SH-SY5Y cells. catechol 13-25 amyloid beta precursor protein Homo sapiens 34-39 30009768-4 2018 UDP-glucuronosyltransferase 1A8 (UGT1A8) is an important phase II drug-metabolizing enzymes which involved in the metabolism of catechol estrogens. catechol 128-136 UDP glucuronosyltransferase family 1 member A8 Rattus norvegicus 0-31 30009768-4 2018 UDP-glucuronosyltransferase 1A8 (UGT1A8) is an important phase II drug-metabolizing enzymes which involved in the metabolism of catechol estrogens. catechol 128-136 UDP glucuronosyltransferase family 1 member A8 Rattus norvegicus 33-39 30009768-5 2018 Here we found that the mammary nuclear factor erythroid 2-related factor 2 (NRF2) - UGT1A8 signaling was down-regulated in breast cancer rats, whereas treatment with resveratrol could upregulate the expression of NRF2 and UGT1A8, accelerate metabolic elimination of catechol estrogens, inhibit estrogen-induced DNA damage and suppress the pathological development of breast cancer. catechol 266-274 NFE2 like bZIP transcription factor 2 Rattus norvegicus 31-74 30009768-5 2018 Here we found that the mammary nuclear factor erythroid 2-related factor 2 (NRF2) - UGT1A8 signaling was down-regulated in breast cancer rats, whereas treatment with resveratrol could upregulate the expression of NRF2 and UGT1A8, accelerate metabolic elimination of catechol estrogens, inhibit estrogen-induced DNA damage and suppress the pathological development of breast cancer. catechol 266-274 NFE2 like bZIP transcription factor 2 Rattus norvegicus 76-80 30009768-5 2018 Here we found that the mammary nuclear factor erythroid 2-related factor 2 (NRF2) - UGT1A8 signaling was down-regulated in breast cancer rats, whereas treatment with resveratrol could upregulate the expression of NRF2 and UGT1A8, accelerate metabolic elimination of catechol estrogens, inhibit estrogen-induced DNA damage and suppress the pathological development of breast cancer. catechol 266-274 UDP glucuronosyltransferase family 1 member A8 Rattus norvegicus 84-90 30009768-5 2018 Here we found that the mammary nuclear factor erythroid 2-related factor 2 (NRF2) - UGT1A8 signaling was down-regulated in breast cancer rats, whereas treatment with resveratrol could upregulate the expression of NRF2 and UGT1A8, accelerate metabolic elimination of catechol estrogens, inhibit estrogen-induced DNA damage and suppress the pathological development of breast cancer. catechol 266-274 NFE2 like bZIP transcription factor 2 Rattus norvegicus 213-217 29887015-7 2018 Finally, we constructed a Tyrosinase (Tyr) biosensor based on functionalized CB and dihexadecylphosphate (DHP) for the determination of catechol in water samples. catechol 136-144 tyrosinase Homo sapiens 26-36 29887015-7 2018 Finally, we constructed a Tyrosinase (Tyr) biosensor based on functionalized CB and dihexadecylphosphate (DHP) for the determination of catechol in water samples. catechol 136-144 tyrosinase Homo sapiens 26-29 29893871-4 2018 Metabolic profiling of roots and root exudates revealed that, upon iron deficiency, secretion of catechol-bearing O-methylated coumarins such as fraxetin, hydroxyfraxetin, and methoxyfraxetin to the rhizosphere was compromised in NtPDR3-silenced plants. catechol 97-105 pleiotropic drug resistance protein 3 Nicotiana tabacum 230-236 29654831-8 2018 This was mirrored by significant downregulating of the expression of estrogen and catechol estrogen-synthesizing enzymes (CYP19, CYP1A1 and CYP1B1) within prostate cancer cells. catechol 82-90 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 122-127 29946611-2 2018 LH2 features a hard potentially dianionic catechol chelate for binding Mo(vi) and a soft iminopyridine chelate for binding Cu(i). catechol 42-50 LIM homeobox 2 Homo sapiens 0-3 29654831-8 2018 This was mirrored by significant downregulating of the expression of estrogen and catechol estrogen-synthesizing enzymes (CYP19, CYP1A1 and CYP1B1) within prostate cancer cells. catechol 82-90 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 129-135 29654831-8 2018 This was mirrored by significant downregulating of the expression of estrogen and catechol estrogen-synthesizing enzymes (CYP19, CYP1A1 and CYP1B1) within prostate cancer cells. catechol 82-90 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 140-146 29654831-9 2018 On the other hand, FTY720 significantly upregulated the expression of catechol estrogen-detoxifying enzyme (COMT). catechol 70-78 catechol-O-methyltransferase Homo sapiens 108-112 29367018-7 2018 The peak currents of the catechol (an electroactive probe) were linearly related to the logarithm of the concentrations of target DNA in the range 100.0 muM to 10.0 pM, with a detection limit of 1.0 pM for the DNA strand. catechol 25-33 latexin Homo sapiens 153-156 29923292-0 2018 A Catechol-Type Resveratrol Analog Manifests Antiangiogenic Action by Constructing an Efficient Catalytic Redox Cycle with Intracellular Copper Ions and NQO1. catechol 2-10 NAD(P)H quinone dehydrogenase 1 Gallus gallus 153-157 29922647-2 2018 PPO activity at the 70 C for 10 min was still activated and drastically decreased since 20-60 min with catechol and pyrogallol as substrate. catechol 103-111 polyphenol oxidase, chloroplastic Malus domestica 0-3 29436602-7 2018 To generate an in vitro preeclampsia environment, human placenta-derived BeWo cells were incubated under hypoxic conditions, or treated with catechol-O-methyl transferase inhibitor (COMT-in) or L-NG-nitroarginine methyl ester (L-NAME). catechol 141-149 catechol-O-methyltransferase Homo sapiens 182-186 29679384-3 2018 We have determined crystal structures of SOD1 in complex with a naphthalene-catechol-linked compound which binds with low micro-molar affinity to a site important for oxidative damage-induced aggregation. catechol 76-84 superoxide dismutase 1 Homo sapiens 41-45 29543451-4 2018 With the exception of DeltaNOD, the presence of an intact catechol structure was obligatory for the inhibition of VCAM-1 and the induction of HO-1 expression. catechol 58-66 vascular cell adhesion molecule 1 Homo sapiens 114-120 29543451-4 2018 With the exception of DeltaNOD, the presence of an intact catechol structure was obligatory for the inhibition of VCAM-1 and the induction of HO-1 expression. catechol 58-66 heme oxygenase 1 Homo sapiens 142-146 29345430-2 2018 These wearable electrochemical sensors are capable of detecting the presence of the tyrosinase (TYR) enzyme cancer biomarker in the presence of its catechol substrate, immobilized on the transducer surface. catechol 148-156 tyrosinase Homo sapiens 84-94 29345430-2 2018 These wearable electrochemical sensors are capable of detecting the presence of the tyrosinase (TYR) enzyme cancer biomarker in the presence of its catechol substrate, immobilized on the transducer surface. catechol 148-156 tyrosinase Homo sapiens 96-99 29345430-3 2018 In the presence of the surface TYR biomarker, the immobilized catechol is rapidly converted to benzoquinone that is detected amperometrically, with a current signal proportional to the TYR level. catechol 62-70 tyrosinase Homo sapiens 31-34 29345430-3 2018 In the presence of the surface TYR biomarker, the immobilized catechol is rapidly converted to benzoquinone that is detected amperometrically, with a current signal proportional to the TYR level. catechol 62-70 tyrosinase Homo sapiens 185-188 29355013-5 2018 Thermodynamic analyses suggest that ETC with more catechol moieties has a stronger binding capacity with NGAL especially in the presence of Fe3+. catechol 50-58 lipocalin 2 Homo sapiens 105-109 29353485-0 2018 Identification and Quantification of 4-Nitrocatechol Formed from OH and NO3 Radical-Initiated Reactions of Catechol in Air in the Presence of NOx: Implications for Secondary Organic Aerosol Formation from Biomass Burning. catechol 107-115 NBL1, DAN family BMP antagonist Homo sapiens 72-75 29353485-3 2018 In this study, catechol was reacted with OH and NO3 radicals in the presence of NOx in an environmental chamber to simulate daytime and nighttime chemistry. catechol 15-23 NBL1, DAN family BMP antagonist Homo sapiens 48-51 29353721-5 2018 Compound 23 bearing pyrimidine core functionalized with catechol, pyridine and trifluoromethyl groups can effectively inhibit the PDE4B with IC50 value in nanomolar range (IC50 = 15 +- 0.4 nM). catechol 56-64 phosphodiesterase 4B, cAMP specific Mus musculus 130-135 29359939-2 2018 Here, we report the formation of the catechol-fused bis(methylthio)tetrathiafulvalene (H2Cat-BMT-TTF) adlayer hydrogen bonding with an imidazole-terminated alkanethiolate self-assembled monolayer (Im-SAM) on Au(111). catechol 37-45 ras homolog family member H Homo sapiens 97-100 29168878-1 2018 Quercetin and fisetin, known as catechol-containing flavonoids, could positively affect the absorption of catechins due to their strong affinity for catechol-O-methyl transferase (COMT), which can methylate and cause the excretion of catechins. catechol 32-40 catechol-O-methyltransferase Homo sapiens 149-178 29168878-1 2018 Quercetin and fisetin, known as catechol-containing flavonoids, could positively affect the absorption of catechins due to their strong affinity for catechol-O-methyl transferase (COMT), which can methylate and cause the excretion of catechins. catechol 32-40 catechol-O-methyltransferase Homo sapiens 180-184 29410835-2 2018 Methylation plays important roles in catechol elimination, although thus far the effects of structural modifications on the metabolic selectivity and the catalytic efficacy of human catechol-O-methyltransferase (COMT) remain unclear. catechol 37-45 catechol-O-methyltransferase Homo sapiens 182-210 29410835-2 2018 Methylation plays important roles in catechol elimination, although thus far the effects of structural modifications on the metabolic selectivity and the catalytic efficacy of human catechol-O-methyltransferase (COMT) remain unclear. catechol 37-45 catechol-O-methyltransferase Homo sapiens 212-216 30305593-4 2018 The tyrosinase enzyme was covalently immobilized onto the PB-NiO deposited SPCE for selective detection and estimation of catechol through electrochemical methods via cyclic voltammetry (CV) and chronoamperometric techniques. catechol 122-130 tyrosinase Homo sapiens 4-14 30305593-1 2018 An amperometric biosensor has been developed for highly efficient and sensitive detection of catechol using Prussian blue (PB)-coated nickel oxide (NiO) nanoparticles (NPs) as a matrix for the immobilization of tyrosinase enzyme. catechol 93-101 tyrosinase Homo sapiens 211-221 30305593-5 2018 The functionalization of tyrosinase on the electrode surface was verified by atomic force microscopy (AFM) and scanning electron microscopic (SEM) techniques and the electrochemical response studies of the proposed biosensor showed high sensitivity of 0.954 muA/muM for catechol in a wide linear range (1 - 50 muM) with low detection limit (LOD) of 0.087 muM. catechol 270-278 tyrosinase Homo sapiens 25-35 30305593-5 2018 The functionalization of tyrosinase on the electrode surface was verified by atomic force microscopy (AFM) and scanning electron microscopic (SEM) techniques and the electrochemical response studies of the proposed biosensor showed high sensitivity of 0.954 muA/muM for catechol in a wide linear range (1 - 50 muM) with low detection limit (LOD) of 0.087 muM. catechol 270-278 latexin Homo sapiens 262-265 29222480-2 2017 Although it is of significant interest for the biosynthesis of catechol derivatives, the rapid catechol oxidase activity and inactivation of tyrosinase have hampered its practical utilization as a monophenol monooxygenase. catechol 63-71 tyrosinase Homo sapiens 141-151 29594363-3 2017 The electrode shows excellent activity towards the oxidation of catechol acting as an electrochemical probe, best at a working potential of 0.16 V. The electrode was modified with antibody against CA15-3. catechol 64-72 mucin 1, cell surface associated Homo sapiens 197-203 29594363-4 2017 Once the analyte (CA15-3) binds to the surface of the electrode, the response to catechol is reduced. catechol 81-89 mucin 1, cell surface associated Homo sapiens 18-24 29136639-8 2017 Computational simulations of the interaction of beta-arbutin, deoxyarbutin and their o-diphenol products with tyrosinase show how these ligands bind at the copper centre of tyrosinase. catechol 85-95 tyrosinase Homo sapiens 110-120 28970059-4 2017 We identified ortho-dihydroxyl groups and an alpha,beta-unsaturated system attached to a catechol as the key structural requirements for Hmox1 induction. catechol 89-97 heme oxygenase 1 Mus musculus 137-142 29058874-3 2017 In this study, we report a simple and direct seed-mediated synthesis of monodispersed multibranched AuNPs using the catechol-containing LAT-1 ligands, L- and D-dopa, to confer active cancer targeting. catechol 116-124 solute carrier family 7 member 5 Homo sapiens 136-141 28573890-0 2017 Resorcinol-, catechol- and saligenin-based bronchodilating beta2-agonists as inhibitors of human cholinesterase activity. catechol 13-21 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 59-64 28573890-0 2017 Resorcinol-, catechol- and saligenin-based bronchodilating beta2-agonists as inhibitors of human cholinesterase activity. catechol 13-21 butyrylcholinesterase Homo sapiens 97-111 28933564-4 2017 A flavonoid with two catechol groups in A- and B-rings, together with a 3-OH group at C-ring, was the most active, presenting an IC50 much lower than the one found for the most widely prescribed alpha-glucosidase inhibitor, acarbose. catechol 21-29 sucrase-isomaltase Homo sapiens 195-212 29136639-8 2017 Computational simulations of the interaction of beta-arbutin, deoxyarbutin and their o-diphenol products with tyrosinase show how these ligands bind at the copper centre of tyrosinase. catechol 85-95 tyrosinase Homo sapiens 173-183 28964634-1 2017 A series of catechol and dioxolane analogs containing thiazole CGA derivatives have been synthesized and evaluated for their inhibitory activity against alpha-MSH. catechol 12-20 chromogranin A Homo sapiens 63-66 28964634-1 2017 A series of catechol and dioxolane analogs containing thiazole CGA derivatives have been synthesized and evaluated for their inhibitory activity against alpha-MSH. catechol 12-20 proopiomelanocortin Homo sapiens 153-162 28592715-1 2017 A series of methyl ester of clovamide analogues, where the hydroxyl group of catechol moiety in caffeic acid and L-3,4-dihydroxyphenylalanine (L-dopa) was replaced with various functional groups, were synthesized and their inhibitory effects on nitric oxide (NO) production and inducible NO synthase (iNOS) expression in lipopolysaccharide (LPS)-induced BV2 cells were tested. catechol 77-85 nitric oxide synthase 2, inducible Mus musculus 278-299 28888661-5 2017 The primary SAR study showed that restricting the conformation of the catechol moiety in rolipram with the scaffold of oxazolidinone-fused tetrahydroisoquinoline could lead to an increase in selectivity for PDE4B over PDE4D, which was consistent with the observed docking simulation. catechol 70-78 phosphodiesterase 4B Homo sapiens 207-212 28888661-5 2017 The primary SAR study showed that restricting the conformation of the catechol moiety in rolipram with the scaffold of oxazolidinone-fused tetrahydroisoquinoline could lead to an increase in selectivity for PDE4B over PDE4D, which was consistent with the observed docking simulation. catechol 70-78 phosphodiesterase 4D Homo sapiens 218-223 28830811-7 2017 The inactivation of GAPDH was dependent on both the catechol and aldehyde moieties of DOPAL. catechol 52-60 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 20-25 28857554-3 2017 In this study, PPF was successfully functionalized with Bioglass and a novel catechol-bearing peptide bioconjugate containing bioactive short peptide sequences of basic fibroblast growth factor, bone morphogenetic protein 2, and osteogenic growth peptide. catechol 77-85 bone morphogenetic protein 2 Homo sapiens 195-223 28592715-1 2017 A series of methyl ester of clovamide analogues, where the hydroxyl group of catechol moiety in caffeic acid and L-3,4-dihydroxyphenylalanine (L-dopa) was replaced with various functional groups, were synthesized and their inhibitory effects on nitric oxide (NO) production and inducible NO synthase (iNOS) expression in lipopolysaccharide (LPS)-induced BV2 cells were tested. catechol 77-85 nitric oxide synthase 2, inducible Mus musculus 301-305 28552822-5 2017 The mRNA expression of alpha-, beta- and gamma-globin genes, erythroid heme synthesis enzymes PBGD and ALAS2, transcription factor GATA-1 and NF-E2 showed a significant increase in K562 cells exposed to 20muM catechol for 3w, and catechol enhanced hemin-induced mRNA expression of these genes. catechol 209-217 hemoglobin subunit alpha 2 Homo sapiens 23-53 28552822-5 2017 The mRNA expression of alpha-, beta- and gamma-globin genes, erythroid heme synthesis enzymes PBGD and ALAS2, transcription factor GATA-1 and NF-E2 showed a significant increase in K562 cells exposed to 20muM catechol for 3w, and catechol enhanced hemin-induced mRNA expression of these genes. catechol 230-238 hemoglobin subunit alpha 2 Homo sapiens 23-53 28557441-4 2017 This consists of tyrosinase-oxidized phenolic groups of a heparin derivative (heparin-grafted tyramine, HT) to catechol groups, followed by immobilizing heparin and inducing the in situ Ag NP formation onto poly(urethane) (PU) substrates. catechol 111-119 tyrosinase Homo sapiens 17-27 28437005-1 2017 KEY POINTS: The catechol metabolites of 17beta-oestradiol (E2 beta), 2-hydroxyoestradiol (2-OHE2 ) and 4-hydroxyoestradiol (4-OHE2 ), stimulate proliferation of pregnancy-derived ovine uterine artery endothelial cells (P-UAECs) through beta-adrenoceptors (beta-ARs) and independently of the classic oestrogen receptors (ERs). catechol 16-24 dihydrolipoamide branched chain transacylase E2 Homo sapiens 59-66 28644401-1 2017 A novel catechol (CA) biosensor was developed by embedding tyrosinase (Tyr) onto in situ electrochemical reduction graphene (EGR) on choline-functionalized gold nanoparticle (AuNPs-Ch) film. catechol 8-16 tyrosinase Homo sapiens 59-69 28644401-1 2017 A novel catechol (CA) biosensor was developed by embedding tyrosinase (Tyr) onto in situ electrochemical reduction graphene (EGR) on choline-functionalized gold nanoparticle (AuNPs-Ch) film. catechol 8-16 tyrosinase Homo sapiens 71-74 28851974-5 2017 Using lipoxygenase inhibitor catechol, it is demonstrated that lipid peroxidation is initiated by lipoxygenase. catechol 29-37 lipoxygenase 1 Arabidopsis thaliana 6-18 28851974-5 2017 Using lipoxygenase inhibitor catechol, it is demonstrated that lipid peroxidation is initiated by lipoxygenase. catechol 29-37 lipoxygenase 1 Arabidopsis thaliana 98-110 28852023-3 2017 The results showed that a dense, robust, and water-resistant adhesive layer was constructed between network-bound catechol moieties in the TAPI and SM system, endowing the STP adhesive with high wet bonding strength for plywood. catechol 114-122 sorbitol-like transporter Glycine max 172-175 28842557-7 2017 Drug release studies show that facile release of the anticancer drug BTZ from the surface of the polydopamine-coated stent could be achieved by the dissociation between catechol groups of polydopamine and the boronic acid functionality of BTZ in a pH-dependent manner. catechol 169-177 CASC3 exon junction complex subunit Homo sapiens 69-72 28511130-0 2017 Design, synthesis and biological evaluation of uncharged catechol derivatives as selective inhibitors of PTP1B. catechol 57-65 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 105-110 28511130-3 2017 Based on active natural products, two series of uncharged catechol derivatives were identified as PTP1B inhibitors by targeting a secondary aryl phosphate-binding site as well as the catalytic site. catechol 58-66 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 98-103 28825621-2 2017 In this study, we report the inhibitory potency of bovine LF (bLF) on catechol-O-methyltransferase (COMT), which catalyzes methylation of catechol substrates. catechol 70-78 lactotransferrin Bos taurus 58-60 28825621-2 2017 In this study, we report the inhibitory potency of bovine LF (bLF) on catechol-O-methyltransferase (COMT), which catalyzes methylation of catechol substrates. catechol 70-78 COMT Bos taurus 100-104 28473194-1 2017 OBJECTIVES: The Val158Met polymorphism in catechol-O-methyltransferase (COMT) enzyme reduces the methylation of catechol estrogens, which may affect mammographic density. catechol 42-50 catechol-O-methyltransferase Homo sapiens 72-76 31105178-0 2017 2-S-Lipoylcaffeic Acid, a Natural Product-Based Entry to Tyrosinase Inhibition via Catechol Manipulation. catechol 83-91 tyrosinase Homo sapiens 57-67 28968204-1 2017 Catechol-O-methyltransferase (COMT) is an abundant S-adenosylmethionine (SAM-)-dependent methyltransferase that methylates catechol compounds, including catecholamines and catecholestrogens.COMT gene located at chromosome 22q11.2 contains a functional polymorphism at codon 158(Val158Met), which has been related to psychiatric diseases and different types of cancer. catechol 123-131 catechol-O-methyltransferase Homo sapiens 0-28 28968204-1 2017 Catechol-O-methyltransferase (COMT) is an abundant S-adenosylmethionine (SAM-)-dependent methyltransferase that methylates catechol compounds, including catecholamines and catecholestrogens.COMT gene located at chromosome 22q11.2 contains a functional polymorphism at codon 158(Val158Met), which has been related to psychiatric diseases and different types of cancer. catechol 123-131 catechol-O-methyltransferase Homo sapiens 30-34 28968204-1 2017 Catechol-O-methyltransferase (COMT) is an abundant S-adenosylmethionine (SAM-)-dependent methyltransferase that methylates catechol compounds, including catecholamines and catecholestrogens.COMT gene located at chromosome 22q11.2 contains a functional polymorphism at codon 158(Val158Met), which has been related to psychiatric diseases and different types of cancer. catechol 123-131 catechol-O-methyltransferase Homo sapiens 190-194 28421738-5 2017 Relying on the requirements of Abeta recognition, we identified the catechol derivative 12. catechol 68-76 amyloid beta precursor protein Homo sapiens 31-36 28399452-4 2017 Mechanism studies indicate that its cytoprotective effects are mediated by activating the Nrf2 signaling pathway in the Michael acceptor- and catechol-dependent manners. catechol 142-150 NFE2 like bZIP transcription factor 2 Homo sapiens 90-94 28259166-10 2017 Catechol, yielding the greatest bioactivity in G6Pase and glucose uptake assays, decreased G6Pase activity by 54%, increased GS by 2-fold and stimulated glucose uptake by 44% at 45.5 muM. catechol 0-8 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 47-53 28340779-4 2017 Mechanistic studies show that catechol group and sulfur atom in L all participate in the coordination with Hg2+, though catechol group contributes mainly to chelation-enhanced fluorescence enhancement and sulfur atom to selectivity. catechol 30-38 polycystin 1, transient receptor potential channel interacting pseudogene 2 Homo sapiens 107-110 27939670-1 2017 Catechol-O-methyltransferase (COMT) is involved in the methylation and inactivation of endogenous and xenobiotic catechol compounds, and serves as a common biochemical link in the catecholamine and catecholestrogen metabolism. catechol 113-121 catechol-O-methyltransferase Homo sapiens 30-34 27939670-6 2017 The catfish Comt shared conserved putative structural regions important for S-adenosyl methionine (AdoMet)- and catechol-binding, transmembrane regions, two glycosylation sites (N-65 and N-91) at the N-terminus and two phosphorylation sites (Ser-235 and Thr-240) at the C-terminus. catechol 112-120 catechol-O-methyltransferase Homo sapiens 12-16 28493937-3 2017 This complex could evolve in two ways: by oxidizing the originated o-diphenol to o-quinone and deoxy-tyrosinase, or by delivering the o-diphenol and met-tyrosinase to the medium, which would produce the self-activation of the system. catechol 67-77 tyrosinase Homo sapiens 101-111 27981425-1 2017 Catechol O-methyltransferase (COMT) is an enzyme that plays a major role in catechol neurotransmitter deactivation. catechol 76-84 catechol-O-methyltransferase Homo sapiens 0-28 27981425-1 2017 Catechol O-methyltransferase (COMT) is an enzyme that plays a major role in catechol neurotransmitter deactivation. catechol 76-84 catechol-O-methyltransferase Homo sapiens 30-34 28259166-10 2017 Catechol, yielding the greatest bioactivity in G6Pase and glucose uptake assays, decreased G6Pase activity by 54%, increased GS by 2-fold and stimulated glucose uptake by 44% at 45.5 muM. catechol 0-8 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 91-97 27497234-5 2016 In comparison with human CYP2E1, camel CYP2E1 more efficiently binds to small toxins as aniline, benzene, catechol, amides, butadiene, toluene and acrylamide. catechol 106-114 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 25-31 28012343-3 2017 To this purpose, we evaluated the capability of tyrosinase to oxidize a natural o-diphenol substrate to o-quinone analyzing the changes in the UV-Vis spectrum of a solution of caffeic acid and the reduction of the cathodic current in a tyrosinase-biosensor, respectively. catechol 80-90 tyrosinase Homo sapiens 48-58 28012343-3 2017 To this purpose, we evaluated the capability of tyrosinase to oxidize a natural o-diphenol substrate to o-quinone analyzing the changes in the UV-Vis spectrum of a solution of caffeic acid and the reduction of the cathodic current in a tyrosinase-biosensor, respectively. catechol 80-90 tyrosinase Homo sapiens 236-246 27744069-7 2017 H2O2 generated during catechol crosslinking exhibited localized cytotoxicity in culture and upregulated the expression of an antioxidant enzyme, peroxiredoxin 2, in primary dermal and tendon fibroblasts. catechol 22-30 peroxiredoxin 2 Homo sapiens 145-160 28222028-5 2017 Human SULT1C4 has previously been shown to sulfonate estrogenic compounds, such as catechol estrogens; therefore, this study focused on the expression and purification of hSULT1C4 in order to further characterize this enzyme"s sulfonation of estrogenic compounds. catechol 83-91 sulfotransferase family 1C member 4 Homo sapiens 6-13 27687332-1 2016 With the capability to inhibit the formation of amyloid beta peptides (Abeta) fibril, dopamine (DA) and other catechol derivatives have been considered for the potential treatment of Alzheimer"s disease (AD). catechol 110-118 amyloid beta precursor protein Homo sapiens 71-76 26751827-1 2016 The fabrication, characterization and analytical performances were investigated for a catechol biosensor, based on the PEDOT-rGO-Fe2O3-PPO composite modified glassy carbon (GC) electrode. catechol 86-94 protoporphyrinogen oxidase Homo sapiens 135-138 27595158-5 2016 Using phenol as a substrate and NADH as reducing agent, which showed negligible background due to low electroactivity of phenol and high oxidation overpotential of NADH, the oxygenation activity of tyrosinase could convert poorly electroactive phenol to highly electroactive catechol to trigger an NADH-related nonenzymatic electrochemical-chemical (EC) catalysis. catechol 275-283 tyrosinase Homo sapiens 198-208 27424082-4 2016 To demonstrate the versatility of this catechol chemoselective reaction, we used four proteins (lysozyme, basic-fibroblast growth factor (bFGF), granulocyte-colony stimulating factor (G-CSF), insulin, and erythropoietin (EPO)) as well as two peptides (hinge-3 and laminin-derived peptide (LDP)). catechol 39-47 fibroblast growth factor 2 Homo sapiens 106-136 27424082-4 2016 To demonstrate the versatility of this catechol chemoselective reaction, we used four proteins (lysozyme, basic-fibroblast growth factor (bFGF), granulocyte-colony stimulating factor (G-CSF), insulin, and erythropoietin (EPO)) as well as two peptides (hinge-3 and laminin-derived peptide (LDP)). catechol 39-47 colony stimulating factor 3 Homo sapiens 184-189 28230729-0 2017 Catechol Groups Enable Reactive Oxygen Species Scavenging-Mediated Suppression of PKD-NFkappaB-IL-8 Signaling Pathway by Chlorogenic and Caffeic Acids in Human Intestinal Cells. catechol 0-8 protein kinase D1 Homo sapiens 82-85 28230729-0 2017 Catechol Groups Enable Reactive Oxygen Species Scavenging-Mediated Suppression of PKD-NFkappaB-IL-8 Signaling Pathway by Chlorogenic and Caffeic Acids in Human Intestinal Cells. catechol 0-8 C-X-C motif chemokine ligand 8 Homo sapiens 95-99 28230729-6 2017 Therefore, we conclude that the presence of catechol groups in CHA and CA allows scavenging of intracellular ROS, thereby inhibiting H2O2-induced IL-8 production via suppression of PKD-NF-kappaB signaling in human intestinal epithelial cells. catechol 44-52 C-X-C motif chemokine ligand 8 Homo sapiens 146-150 28230729-6 2017 Therefore, we conclude that the presence of catechol groups in CHA and CA allows scavenging of intracellular ROS, thereby inhibiting H2O2-induced IL-8 production via suppression of PKD-NF-kappaB signaling in human intestinal epithelial cells. catechol 44-52 protein kinase D1 Homo sapiens 181-184 27890888-1 2017 Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of endogenous catechol amines and estrogens and exogenous catechol-type of drugs. catechol 78-86 catechol O-methyltransferase Callithrix jacchus 0-28 27890888-1 2017 Catechol-O-methyltransferase (COMT) catalyzes the O-methylation of endogenous catechol amines and estrogens and exogenous catechol-type of drugs. catechol 78-86 catechol O-methyltransferase Callithrix jacchus 30-34 27826992-1 2017 Catechol-O-methyltransferase, COMT, is an important phase II enzyme catalyzing the transfer of a methyl-group from S-adenosylmethionine to a catechol-containing substrate molecule. catechol 141-149 catechol-O-methyltransferase Homo sapiens 0-28 27826992-1 2017 Catechol-O-methyltransferase, COMT, is an important phase II enzyme catalyzing the transfer of a methyl-group from S-adenosylmethionine to a catechol-containing substrate molecule. catechol 141-149 catechol-O-methyltransferase Homo sapiens 30-34 27826992-2 2017 A genetic variant Val158Met in the COMT gene leads to a several-fold decrease in the enzymatic activity giving rise to the accumulation of potentially carcinogenic endogenous catechol estrogens and their reactive intermediates and increasing thus the risk of tumorigenesis. catechol 175-183 catechol-O-methyltransferase Homo sapiens 35-39 27826992-4 2017 In this review article, the important contribution of dietary catechol-containing flavonoids to modification of the relationships between the COMT genotype and cancer risk is discussed. catechol 62-70 catechol-O-methyltransferase Homo sapiens 142-146 27826992-5 2017 Whereas, the diverse anticancer activities of common phytochemicals, such as green tea polyphenols, quercetin, fisetin or luteolin, can be markedly changed (both decreased or increased) by the COMT-mediated O-methylation of these exogenous substrates, flavonoids can also behave as potent inhibitors of the COMT enzyme slowing detoxification of endogenous catechol estrogens. catechol 356-364 catechol-O-methyltransferase Homo sapiens 193-197 27826992-5 2017 Whereas, the diverse anticancer activities of common phytochemicals, such as green tea polyphenols, quercetin, fisetin or luteolin, can be markedly changed (both decreased or increased) by the COMT-mediated O-methylation of these exogenous substrates, flavonoids can also behave as potent inhibitors of the COMT enzyme slowing detoxification of endogenous catechol estrogens. catechol 356-364 catechol-O-methyltransferase Homo sapiens 307-311 27826992-6 2017 Such a many-featured functioning of the COMT and its complex regulation by several different genetic and environmental factors, including plant-based food ingredients, emphasizes the necessity to further stratify the association studies between the COMT genotype and tumor risk by consumption of catechol-containing dietary flavonoids. catechol 296-304 catechol-O-methyltransferase Homo sapiens 40-44 27826992-6 2017 Such a many-featured functioning of the COMT and its complex regulation by several different genetic and environmental factors, including plant-based food ingredients, emphasizes the necessity to further stratify the association studies between the COMT genotype and tumor risk by consumption of catechol-containing dietary flavonoids. catechol 296-304 catechol-O-methyltransferase Homo sapiens 249-253 30854528-2 2017 Specifically, the catechol estrogen-3,4-quinones can react with DNA to produce a large amount of specific depurinating estrogen-DNA adducts, formed at the N-3 of Ade and N-7 of Gua. catechol 18-26 DExD-box helicase 21 Homo sapiens 177-180 28456872-1 2017 Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols. catechol 83-91 catechol-O-methyltransferase Homo sapiens 0-28 28456872-1 2017 Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols. catechol 83-91 catechol-O-methyltransferase Homo sapiens 30-34 27497234-5 2016 In comparison with human CYP2E1, camel CYP2E1 more efficiently binds to small toxins as aniline, benzene, catechol, amides, butadiene, toluene and acrylamide. catechol 106-114 cytochrome P450 2E1 Camelus bactrianus 39-45 27342394-3 2016 The Em (met-tyrosinase) form is not active on BR, but Eox (oxy-tyrosinase) can act on this molecule, hydroxylating it to o-diphenol. catechol 121-131 tyrosinase Homo sapiens 12-22 27994754-2 2016 The study confirmed mitochondrial import of the catechol derivative 2, which displayed effective antiaggregating activity and neuroprotective effects against Abeta-induced toxicity. catechol 48-56 amyloid beta precursor protein Homo sapiens 158-163 27589224-3 2016 We found that the proton conductivity of PVCa-b-PSt film was increased 10-fold by the addition of Ag NPs into the proton conduction channels filled with catechol moieties. catechol 153-161 sulfotransferase family 1A member 1 Homo sapiens 48-51 27480027-2 2016 If the catalytic cycle is completed with a reductant such as ascorbic acid or an o-diphenol such as 4-tert-butylcatechol, these compounds act as substrates of tyrosinase in all cases. catechol 81-91 tyrosinase Homo sapiens 159-169 27637483-6 2016 Catechol and trihydroxybenzene (activated by CYP2E1) induced micronuclei most strongly at 6h/18h, whereas somewhat longer exposures were optimal for hydroquinone, another compound activated by CYP2E1. catechol 0-8 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 45-51 27637483-6 2016 Catechol and trihydroxybenzene (activated by CYP2E1) induced micronuclei most strongly at 6h/18h, whereas somewhat longer exposures were optimal for hydroquinone, another compound activated by CYP2E1. catechol 0-8 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 193-199 27431615-0 2016 Amylin Amyloid Inhibition by Flavonoid Baicalein: Key Roles of Its Vicinal Dihydroxyl Groups of the Catechol Moiety. catechol 100-108 islet amyloid polypeptide Homo sapiens 0-6 27342394-3 2016 The Em (met-tyrosinase) form is not active on BR, but Eox (oxy-tyrosinase) can act on this molecule, hydroxylating it to o-diphenol. catechol 121-131 tyrosinase Homo sapiens 63-73 27353345-0 2016 Site-specific covalent modifications of human insulin by catechol estrogens: Reactivity and induced structural and functional changes. catechol 57-65 insulin Homo sapiens 46-53 27239955-3 2016 Nuclear magnetic resonance and funnel metadynamics were used to evaluate the binding of pyrocatechol derivatives (catechol, 4-methylcatechol, and 4-tert-butylcatechol) to human peroxiredoxin 5. catechol 88-100 peroxiredoxin 5 Homo sapiens 177-192 27239955-3 2016 Nuclear magnetic resonance and funnel metadynamics were used to evaluate the binding of pyrocatechol derivatives (catechol, 4-methylcatechol, and 4-tert-butylcatechol) to human peroxiredoxin 5. catechol 92-100 peroxiredoxin 5 Homo sapiens 177-192 27239955-6 2016 Here, the catechol derivatives were found to be inhibitors against human peroxiredoxin 5 through a partial mixed type noncompetitive mechanism. catechol 10-18 peroxiredoxin 5 Homo sapiens 73-88 27190241-0 2016 Diversity and distribution of catechol 2, 3-dioxygenase genes in surface sediments of the Bohai Sea. catechol 30-38 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 96-99 26497622-5 2016 Indeed, only catechol derivative 3 [(S)-allyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enethioate] inhibited Abeta fibrilization. catechol 13-21 amyloid beta precursor protein Homo sapiens 102-107 27167001-0 2016 A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer. catechol 26-34 MYC proto-oncogene, bHLH transcription factor Homo sapiens 44-49 27167001-0 2016 A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer. catechol 26-34 mitogen-activated protein kinase 1 Homo sapiens 84-88 27167001-5 2016 Catechol inhibited ERK2 kinase activity in vitro, and its direct binding to the ERK2 active site was confirmed by X-ray crystallography. catechol 0-8 mitogen-activated protein kinase 1 Homo sapiens 19-23 27167001-5 2016 Catechol inhibited ERK2 kinase activity in vitro, and its direct binding to the ERK2 active site was confirmed by X-ray crystallography. catechol 0-8 mitogen-activated protein kinase 1 Homo sapiens 80-84 27167001-6 2016 Phosphorylation of c-Myc, a substrate of ERK2, was decreased in catechol-treated lung cancer cells and resulted in reduced protein stability and subsequent down-regulation of total c-Myc. catechol 64-72 MYC proto-oncogene, bHLH transcription factor Homo sapiens 19-24 27167001-6 2016 Phosphorylation of c-Myc, a substrate of ERK2, was decreased in catechol-treated lung cancer cells and resulted in reduced protein stability and subsequent down-regulation of total c-Myc. catechol 64-72 mitogen-activated protein kinase 1 Homo sapiens 41-45 27167001-6 2016 Phosphorylation of c-Myc, a substrate of ERK2, was decreased in catechol-treated lung cancer cells and resulted in reduced protein stability and subsequent down-regulation of total c-Myc. catechol 64-72 MYC proto-oncogene, bHLH transcription factor Homo sapiens 181-186 27167001-9 2016 In summary, catechol exerted inhibitory effects on the ERK2/c-Myc signaling axis to reduce lung cancer tumor growth in vitro and in vivo, including a preclinical patient-derived xenograft (PDX) model. catechol 12-20 mitogen-activated protein kinase 1 Homo sapiens 55-59 27167001-9 2016 In summary, catechol exerted inhibitory effects on the ERK2/c-Myc signaling axis to reduce lung cancer tumor growth in vitro and in vivo, including a preclinical patient-derived xenograft (PDX) model. catechol 12-20 MYC proto-oncogene, bHLH transcription factor Homo sapiens 60-65 27303894-1 2016 The TK2203 protein from the hyperthermophilic archaeon Thermococcus kodakarensis KOD1 (262 residues, 29 kDa) is a putative extradiol dioxygenase catalyzing the cleavage of C-C bonds in catechol derivatives. catechol 185-193 extradiol dioxygenase Thermococcus kodakarensis KOD1 4-10 27021962-5 2016 Investigation of structure-activity relationships of 6S derivatives indicates that the combination of an alpha,beta-unsaturated carbonyl entity and a catechol moiety in one compound enhances the Tg(gstp1:GFP) fluorescence signal in zebrafish embryos. catechol 150-158 glutathione S-transferase pi 1.2 Danio rerio 198-203 27021962-8 2016 These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1, disrupting the Keap1-Nrf2 complex, thereby liberating and activating Nrf2. catechol 70-78 kelch-like ECH-associated protein 1a Danio rerio 144-149 27021962-8 2016 These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1, disrupting the Keap1-Nrf2 complex, thereby liberating and activating Nrf2. catechol 70-78 kelch-like ECH-associated protein 1a Danio rerio 166-171 27021962-8 2016 These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1, disrupting the Keap1-Nrf2 complex, thereby liberating and activating Nrf2. catechol 70-78 nfe2 like bZIP transcription factor 2a Danio rerio 172-176 27021962-8 2016 These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1, disrupting the Keap1-Nrf2 complex, thereby liberating and activating Nrf2. catechol 70-78 nfe2 like bZIP transcription factor 2a Danio rerio 220-224 27186597-5 2016 The enzyme electrode was tested for the amperometric detection of different phenolic compounds, which displayed excellent analytical behaviour toward catechol with a linear range of response from 200 nM to 15 muM, sensitivity of 93 mA M(-1) cm(-2), and low detection limit of 76 nM. catechol 150-158 latexin Homo sapiens 209-212 26802574-3 2016 In the presence of tyrosinase, phenol can be catalyzed the oxidization into catechol, which could reactive toward the boronic acid functional groups of APBA-CuInS2 QDs to form five-membered cyclic esters, leading to the fluorescence quenching of the QDs. catechol 76-84 tyrosinase Homo sapiens 19-29 26727388-7 2016 Also, the results extracted from (1)H-NMR and voltammetric measurements indicate that the catechol moiety of ARS is involved in the binding mechanism among ARS and alkyloxypyridinium surfactants. catechol 90-98 secreted LY6/PLAUR domain containing 1 Homo sapiens 109-112 26727388-7 2016 Also, the results extracted from (1)H-NMR and voltammetric measurements indicate that the catechol moiety of ARS is involved in the binding mechanism among ARS and alkyloxypyridinium surfactants. catechol 90-98 secreted LY6/PLAUR domain containing 1 Homo sapiens 156-159 26803001-7 2016 The elaborated microsensor showed fast responses towards catechol additions to tap water - a weakly supported medium - characterized by a linear range from 0.2 to 10 muM, a sensitivity of 1.35 +- 0.4 A M(-1) cm(-2) and a dynamic range up to 43 muM. catechol 57-65 nuclear RNA export factor 1 Homo sapiens 79-82 26803001-7 2016 The elaborated microsensor showed fast responses towards catechol additions to tap water - a weakly supported medium - characterized by a linear range from 0.2 to 10 muM, a sensitivity of 1.35 +- 0.4 A M(-1) cm(-2) and a dynamic range up to 43 muM. catechol 57-65 latexin Homo sapiens 166-169 26803001-7 2016 The elaborated microsensor showed fast responses towards catechol additions to tap water - a weakly supported medium - characterized by a linear range from 0.2 to 10 muM, a sensitivity of 1.35 +- 0.4 A M(-1) cm(-2) and a dynamic range up to 43 muM. catechol 57-65 latexin Homo sapiens 244-247 26831215-3 2016 Lipid peroxidation was initiated by enzymatic reaction as inhibition of lipoxygenase by catechol and caffeic acid prevented hydroperoxide formation. catechol 88-96 uncharacterized protein Chlamydomonas reinhardtii 72-84 26867114-6 2016 Our approach relies on the tandem enzymatic reaction of a fungal tyrosinase and the mammalian catechol-O-methyltransferase (COMT), which can effect the sequential hydroxylation of the phenolic group to give an intermediate catechol moiety that is subsequently O-alkylated. catechol 94-102 tyrosinase Homo sapiens 65-75 26867114-6 2016 Our approach relies on the tandem enzymatic reaction of a fungal tyrosinase and the mammalian catechol-O-methyltransferase (COMT), which can effect the sequential hydroxylation of the phenolic group to give an intermediate catechol moiety that is subsequently O-alkylated. catechol 94-102 catechol-O-methyltransferase Homo sapiens 124-128 26674175-2 2016 Taking inspiration from mussels that produce proteins rich in L-3,4-dihydroxyphenylalanine (DOPA) to adhere to a variety of organic and inorganic surfaces, the silk fibroin was functionalized with catechol groups. catechol 197-205 fibroin light chain Bombyx mori 165-172 26674175-4 2016 The synthesis of catechol-functionalized silk fibroin polymers containing varying amounts of hydrophilic polyethylene glycol (PEG, 5000 g/mol) side chains was carried out to balance silk hydrophobicity with PEG hydrophilicity. catechol 17-25 fibroin light chain Bombyx mori 46-53 27556138-3 2016 A series of catechol-based molecules were synthesized and tested for both proteolytic and oxidative inhibitory activity, and the detailed binding mode was assessed by crystal structure determination of the complex between a catechol derivative and the matrix metalloproteinase-8. catechol 12-20 matrix metallopeptidase 8 Homo sapiens 252-278 26077029-0 2016 Oxidative modification of human ceruloplasmin induced by a catechol neurotoxin, salsolinol. catechol 59-67 ceruloplasmin Homo sapiens 32-45 27556138-3 2016 A series of catechol-based molecules were synthesized and tested for both proteolytic and oxidative inhibitory activity, and the detailed binding mode was assessed by crystal structure determination of the complex between a catechol derivative and the matrix metalloproteinase-8. catechol 224-232 matrix metallopeptidase 8 Homo sapiens 252-278 26314862-0 2015 Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- and o-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog. catechol 41-49 NFE2 like bZIP transcription factor 2 Homo sapiens 128-132 26671725-0 2015 Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups. catechol 74-94 microtubule associated protein tau Homo sapiens 6-9 26671725-3 2015 Here we show that tau oligomer formation can be inhibited by compounds whose chemical backbone includes 1,2-dihydroxybenzene. catechol 104-124 microtubule associated protein tau Homo sapiens 18-21 26671725-4 2015 Specifically, we demonstrate that 1,2-dihydroxybenzene-containing compounds bind to and cap cysteine residues of tau and prevent its aggregation by hindering interactions between tau molecules. catechol 34-54 microtubule associated protein tau Homo sapiens 113-116 26671725-4 2015 Specifically, we demonstrate that 1,2-dihydroxybenzene-containing compounds bind to and cap cysteine residues of tau and prevent its aggregation by hindering interactions between tau molecules. catechol 34-54 microtubule associated protein tau Homo sapiens 179-182 26094037-5 2015 Due to the excellent electrocatalytic activity of Ag@Pt-GRs towards the oxidation of catechol, determination of TNF-alpha antigen was based on its obstruction to the electrocatalytic oxidation of catechol by Ag@Pt-GRs after binding to the surface of electrode through interaction with the aptamer. catechol 85-93 tumor necrosis factor Homo sapiens 112-121 26094037-5 2015 Due to the excellent electrocatalytic activity of Ag@Pt-GRs towards the oxidation of catechol, determination of TNF-alpha antigen was based on its obstruction to the electrocatalytic oxidation of catechol by Ag@Pt-GRs after binding to the surface of electrode through interaction with the aptamer. catechol 196-204 tumor necrosis factor Homo sapiens 112-121 26314862-0 2015 Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- and o-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog. catechol 149-157 NFE2 like bZIP transcription factor 2 Homo sapiens 128-132 26320621-3 2015 The docking results showed that the catechol diether moiety of compound 8 played a key role to form integral hydrogen bonds with PDE4B protein while the rest part of the molecule extended into the catalytic domain to block the access of cAMP and formed the foundation for inhibition of PDE4. catechol 36-44 phosphodiesterase 4B Homo sapiens 129-134 26318031-1 2015 We demonstrate that dual release of bone morphogenic protein-2 (BMP-2) and insulin-like growth factor-1 (IGF-1) by catechol-functionalized adhesive polymer nanoparticles on microgrooved titanium (Ti) surface enhances in vitro osteoblastic differentiation of human mesenchymal stem cells (MSCs). catechol 115-123 bone morphogenetic protein 2 Homo sapiens 36-62 26318031-1 2015 We demonstrate that dual release of bone morphogenic protein-2 (BMP-2) and insulin-like growth factor-1 (IGF-1) by catechol-functionalized adhesive polymer nanoparticles on microgrooved titanium (Ti) surface enhances in vitro osteoblastic differentiation of human mesenchymal stem cells (MSCs). catechol 115-123 bone morphogenetic protein 2 Homo sapiens 64-69 26318031-1 2015 We demonstrate that dual release of bone morphogenic protein-2 (BMP-2) and insulin-like growth factor-1 (IGF-1) by catechol-functionalized adhesive polymer nanoparticles on microgrooved titanium (Ti) surface enhances in vitro osteoblastic differentiation of human mesenchymal stem cells (MSCs). catechol 115-123 insulin like growth factor 1 Homo sapiens 75-103 26318031-1 2015 We demonstrate that dual release of bone morphogenic protein-2 (BMP-2) and insulin-like growth factor-1 (IGF-1) by catechol-functionalized adhesive polymer nanoparticles on microgrooved titanium (Ti) surface enhances in vitro osteoblastic differentiation of human mesenchymal stem cells (MSCs). catechol 115-123 insulin like growth factor 1 Homo sapiens 105-110 26450473-3 2015 Tyrosinase hydroxylates the oxyresveratrol to an o-diphenol and oxidizes the latter to an o-quinone, which finally isomerizes to p-quinone. catechol 49-59 tyrosinase Homo sapiens 0-10 26320621-3 2015 The docking results showed that the catechol diether moiety of compound 8 played a key role to form integral hydrogen bonds with PDE4B protein while the rest part of the molecule extended into the catalytic domain to block the access of cAMP and formed the foundation for inhibition of PDE4. catechol 36-44 phosphodiesterase 4A Homo sapiens 129-133 26318993-1 2015 Catechol-based inhibitors of ERCC1-XPF endonuclease activity were identified from a high-throughput screen. catechol 0-8 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 29-34 26318993-1 2015 Catechol-based inhibitors of ERCC1-XPF endonuclease activity were identified from a high-throughput screen. catechol 0-8 ERCC excision repair 4, endonuclease catalytic subunit Homo sapiens 35-38 26419907-2 2015 The enzymatic hydrolysis of o-phosphonoxyphenol (OPP) to catechol (CA) by ALP is allowed to coordinate on the surface of TiO2 nanoparticles (NPs) due to the specificity and high affinity of enediol ligands to Ti(IV). catechol 57-65 alkaline phosphatase, placental Homo sapiens 74-77