PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 25045021-2 2014 In this study, we tested the involvement of mARC in the reduction of N-oxides (amitriptyline-N-oxide, nicotinamide-N-oxide), oximes ((E)-/(Z)-2,4,6-trimethylacetophenonoxime) and a N-hydroxyamidinohydrazone (guanoxabenz). guanoxabenz 208-219 activity regulated cytoskeletal-associated protein Mus musculus 44-48 8097566-4 1993 However, the competition curves for guanoxabenz were definitely biphasic and resolved into two site fits, indicating that guanoxabenz was binding to both high affinity (Kd = 35 nmol/l) and low affinity (Kd = 8900 nmol/l) alpha 2A-adrenoceptor sites in the proportions 57% and 43%, respectively. guanoxabenz 122-133 adrenoceptor alpha 2A Rattus norvegicus 221-242