PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31814905-7	2019	The protein expressions of Nf-kappaB/NLRP3 signaling pathway induced by LPS were inhibited by isochlorogenic acid A.	isochlorogenic acid	94-115	nuclear factor kappa B subunit 1	Homo sapiens	27-36
31814905-0	2019	Isochlorogenic acid A attenuates acute lung injury induced by LPS via Nf-kappaB/NLRP3 signaling pathway.	isochlorogenic acid	0-21	interferon regulatory factor 6	Homo sapiens	62-65
33189843-12	2021	Furthermore, the isochlorogenic acid-rich and biflavonoid-rich fractions and isochlorogenic acids A and C, and ochnaflavone could significantly down-regulate the mRNA expression of TNF-alpha and IL-6 in LPS-induced RAW 264.7 macrophages.	isochlorogenic acid	17-36	tumor necrosis factor	Mus musculus	181-190
33189843-12	2021	Furthermore, the isochlorogenic acid-rich and biflavonoid-rich fractions and isochlorogenic acids A and C, and ochnaflavone could significantly down-regulate the mRNA expression of TNF-alpha and IL-6 in LPS-induced RAW 264.7 macrophages.	isochlorogenic acid	17-36	interleukin 6	Mus musculus	195-199
33189843-12	2021	Furthermore, the isochlorogenic acid-rich and biflavonoid-rich fractions and isochlorogenic acids A and C, and ochnaflavone could significantly down-regulate the mRNA expression of TNF-alpha and IL-6 in LPS-induced RAW 264.7 macrophages.	isochlorogenic acid	77-97	tumor necrosis factor	Mus musculus	181-190
33189843-12	2021	Furthermore, the isochlorogenic acid-rich and biflavonoid-rich fractions and isochlorogenic acids A and C, and ochnaflavone could significantly down-regulate the mRNA expression of TNF-alpha and IL-6 in LPS-induced RAW 264.7 macrophages.	isochlorogenic acid	77-97	interleukin 6	Mus musculus	195-199
32357572-1	2020	Bioassay-guided fractionation of the ethanol extract of whole herbs of Achillea alpina led to the isolation of isochlorogenic acids A and B as transient receptor potential vanilloid 3 (TRPV3) channel antagonists by using a calcium fluorescent assay.	isochlorogenic acid	111-131	transient receptor potential cation channel subfamily V member 3	Homo sapiens	185-190
32357572-2	2020	The structures were identified by spectroscopic analysis and the inhibitory activities of isochlorogenic acids A and B were confirmed by whole-cell patch clamp recordings of human embryonic kidney 293 (HEK293) cells expressing human TRPV3.	isochlorogenic acid	90-110	transient receptor potential cation channel subfamily V member 3	Homo sapiens	233-238
31814905-7	2019	The protein expressions of Nf-kappaB/NLRP3 signaling pathway induced by LPS were inhibited by isochlorogenic acid A.	isochlorogenic acid	94-115	NLR family pyrin domain containing 3	Homo sapiens	37-42
31814905-0	2019	Isochlorogenic acid A attenuates acute lung injury induced by LPS via Nf-kappaB/NLRP3 signaling pathway.	isochlorogenic acid	0-21	nuclear factor kappa B subunit 1	Homo sapiens	70-79
31814905-7	2019	The protein expressions of Nf-kappaB/NLRP3 signaling pathway induced by LPS were inhibited by isochlorogenic acid A.	isochlorogenic acid	94-115	interferon regulatory factor 6	Homo sapiens	72-75
31814905-0	2019	Isochlorogenic acid A attenuates acute lung injury induced by LPS via Nf-kappaB/NLRP3 signaling pathway.	isochlorogenic acid	0-21	NLR family pyrin domain containing 3	Homo sapiens	80-85
31814905-8	2019	In summary, isochlorogenic acid A reversed the effects induced by LPS in acute lung injury and is a promising monomer for therapy of acute lung injury, providing references for future research on therapy of acute lung injury.	isochlorogenic acid	12-33	interferon regulatory factor 6	Homo sapiens	66-69
31814905-3	2019	In this study, we first investigated the possible effects of isochlorogenic acid A in acute lung injury induced by LPS.	isochlorogenic acid	61-82	interferon regulatory factor 6	Homo sapiens	115-118
31485132-8	2019	CGA-conformer C3950 showed best docking than CGA and conformer-ZINC03947476, iso-chlorogenic acid and cischlorogenic acid.	isochlorogenic acid	77-97	chromogranin A	Mus musculus	0-3
31814905-4	2019	The effects of oxidant stress, pulmonary edema and inflammation factors induced by LPS were inhibited by isochlorogenic acid A.	isochlorogenic acid	105-126	interferon regulatory factor 6	Homo sapiens	83-86
31814905-5	2019	Levels of lung active markers and inflammation factors induced by LPS were reversed by isochlorogenic acid A.	isochlorogenic acid	87-108	interferon regulatory factor 6	Homo sapiens	66-69
31814905-6	2019	Isochlorogenic acid A inhibited the cell apoptosis induced by LPS.	isochlorogenic acid	0-21	interferon regulatory factor 6	Homo sapiens	62-65
23073199-1	2012	OBJECTIVE: To investigate the mechanism of binding of human serum albumin (HSA) with potential sensitinogen, including chlorogenic acid and two isochlorogenic acids (3,4-di-O-caffeoylquinic acid and 3,5-di-O-caffeoylquinic acid).	isochlorogenic acid	144-164	albumin	Homo sapiens	60-73
22720874-15	2012	Isochlorogenic acid, a component of C. crepidioides, induced NF-kappaB activation and iNOS expression.	isochlorogenic acid	0-19	nitric oxide synthase 2, inducible	Mus musculus	86-90
35343156-7	2022	The difference in the peak areas of isochlorogenic acid A+isochlorogenic acid D obtained by the optimized method and the method in ChP was not significant, with deviation less than 3.0%, which further proved that the result measured by the method in ChP was the co-effluent of isochlorogenic acid A and isochlorogenic acid D. The optimized method can ensure the accurate quantification of isochlorogenic acid A.	isochlorogenic acid	58-77	calcineurin like EF-hand protein 1	Homo sapiens	250-253
35256942-0	2022	Inhibition of temperature-sensitive TRPV3 channel by two natural isochlorogenic acid isomers for alleviation of dermatitis and chronic pruritus.	isochlorogenic acid	65-84	transient receptor potential cation channel subfamily V member 3	Homo sapiens	36-41
35256942-7	2022	Taken together, our identification of isochlorogenic acids A and B that act as specific TRPV3 channel inhibitors and gating modifiers not only provides an essential pharmacological tool for further investigation of the channel pharmacology and pathology, but also holds developmental potential for treatment of dermatitis and chronic pruritus.	isochlorogenic acid	38-58	transient receptor potential cation channel subfamily V member 3	Homo sapiens	88-93