PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11174202-7	2001	On stimulation with phorbol 12-myristate acetate/ionomycin for 4 hours, in BALF of the patients, but not in peripheral blood, we found a significant increase in the percentage of IFN-gamma-producing CD4+ T cells and a decrease in the percentage of IL-4-producing CD4+ T cells, resulting in a 3.5-fold higher ratio of IFN-gamma/IL-4-producing CD4+ T cells compared with that found in normal subjects.	phorbol 12-myristate acetate	20-48	interferon gamma	Homo sapiens	179-188
15744749-3	2005	Phosphorylation of MAPK/ERK was mimicked by phorbol 12-myristate acetate (PMA), an activator of protein kinase C (PKC), but Cch-evoked MAPK/ERK activation was unaffected by down-regulation of PKC or by pretreatment of cells with GF109203X, a PKC inhibitor.	phorbol 12-myristate acetate	44-72	mitogen-activated protein kinase 1	Homo sapiens	24-27
15744749-3	2005	Phosphorylation of MAPK/ERK was mimicked by phorbol 12-myristate acetate (PMA), an activator of protein kinase C (PKC), but Cch-evoked MAPK/ERK activation was unaffected by down-regulation of PKC or by pretreatment of cells with GF109203X, a PKC inhibitor.	phorbol 12-myristate acetate	44-72	protein kinase C zeta	Homo sapiens	114-117
12534554-6	2003	RESULTS: A significantly lower ratio of IFN-gamma-/IL-4-producing CD4+ T cells after phorbol 12-myristate acetate/ionomycin stimulation was found in patients with atopic cough and atopic asthma compared with normal subjects.	phorbol 12-myristate acetate	85-113	interferon gamma	Homo sapiens	40-49
12534554-6	2003	RESULTS: A significantly lower ratio of IFN-gamma-/IL-4-producing CD4+ T cells after phorbol 12-myristate acetate/ionomycin stimulation was found in patients with atopic cough and atopic asthma compared with normal subjects.	phorbol 12-myristate acetate	85-113	interleukin 4	Homo sapiens	51-55
12020766-4	2002	Phosphorylation of ERK1/2 was mimicked by the protein kinase C (PKC) activator phorbol 12-myristate acetate (PMA), but was not altered either by PKC inhibitor GF109203X or by down-regulation of PKC.	phorbol 12-myristate acetate	79-107	mitogen activated protein kinase 3	Rattus norvegicus	19-25
11174202-7	2001	On stimulation with phorbol 12-myristate acetate/ionomycin for 4 hours, in BALF of the patients, but not in peripheral blood, we found a significant increase in the percentage of IFN-gamma-producing CD4+ T cells and a decrease in the percentage of IL-4-producing CD4+ T cells, resulting in a 3.5-fold higher ratio of IFN-gamma/IL-4-producing CD4+ T cells compared with that found in normal subjects.	phorbol 12-myristate acetate	20-48	interleukin 4	Homo sapiens	248-252
11174202-7	2001	On stimulation with phorbol 12-myristate acetate/ionomycin for 4 hours, in BALF of the patients, but not in peripheral blood, we found a significant increase in the percentage of IFN-gamma-producing CD4+ T cells and a decrease in the percentage of IL-4-producing CD4+ T cells, resulting in a 3.5-fold higher ratio of IFN-gamma/IL-4-producing CD4+ T cells compared with that found in normal subjects.	phorbol 12-myristate acetate	20-48	interferon gamma	Homo sapiens	317-326
11174202-7	2001	On stimulation with phorbol 12-myristate acetate/ionomycin for 4 hours, in BALF of the patients, but not in peripheral blood, we found a significant increase in the percentage of IFN-gamma-producing CD4+ T cells and a decrease in the percentage of IL-4-producing CD4+ T cells, resulting in a 3.5-fold higher ratio of IFN-gamma/IL-4-producing CD4+ T cells compared with that found in normal subjects.	phorbol 12-myristate acetate	20-48	interleukin 4	Homo sapiens	327-331
9419976-5	1997	In contrast, phorbol 12-myristate acetate induced marked c-fos mRNA elevation in both WEHI7.2 and W.Hb12 cells, indicating that the inhibitory effect of Bcl-2 is selective for induction of c-fos by Ca2+.	phorbol 12-myristate acetate	13-41	FBJ osteosarcoma oncogene	Mus musculus	57-62
9409644-7	1997	In activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h. The levels of IL-2 and IFN-gamma in CD8+ and CD8- T cells in four healthy individuals were consistent on four occasions over a 3-month period.	phorbol 12-myristate acetate	116-144	CD8a molecule	Homo sapiens	13-16
9409644-7	1997	In activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h. The levels of IL-2 and IFN-gamma in CD8+ and CD8- T cells in four healthy individuals were consistent on four occasions over a 3-month period.	phorbol 12-myristate acetate	116-144	interleukin 2	Homo sapiens	27-31
9409644-7	1997	In activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h. The levels of IL-2 and IFN-gamma in CD8+ and CD8- T cells in four healthy individuals were consistent on four occasions over a 3-month period.	phorbol 12-myristate acetate	116-144	interferon gamma	Homo sapiens	36-52
9409644-7	1997	In activated CD8- T cells, IL-2 and interferon-gamma (IFN-gamma) were optimally induced after 10 h stimulation with phorbol 12-myristate acetate (PMA)/ionomycin, and in CD8+ T cells IL-2 was optimally induced after 10 h and IFN-gamma after 6 h. The levels of IL-2 and IFN-gamma in CD8+ and CD8- T cells in four healthy individuals were consistent on four occasions over a 3-month period.	phorbol 12-myristate acetate	116-144	interferon gamma	Homo sapiens	54-63
9419976-5	1997	In contrast, phorbol 12-myristate acetate induced marked c-fos mRNA elevation in both WEHI7.2 and W.Hb12 cells, indicating that the inhibitory effect of Bcl-2 is selective for induction of c-fos by Ca2+.	phorbol 12-myristate acetate	13-41	B cell leukemia/lymphoma 2	Mus musculus	153-158
9419976-5	1997	In contrast, phorbol 12-myristate acetate induced marked c-fos mRNA elevation in both WEHI7.2 and W.Hb12 cells, indicating that the inhibitory effect of Bcl-2 is selective for induction of c-fos by Ca2+.	phorbol 12-myristate acetate	13-41	FBJ osteosarcoma oncogene	Mus musculus	189-194
8327407-1	1993	Nanomolar concentrations of leukotriene C4 and phorbol 12-myristate acetate, a protein kinase C activator, stimulated endothelin-1 release by vascular endothelial but not smooth muscle cells.	phorbol 12-myristate acetate	47-75	endothelin 1	Homo sapiens	118-130
1985890-4	1991	PKC beta was down-regulated following treatment of thymocytes with phorbol 12-myristate acetate (PMA) (2 x 10(-8) M) or ionomycin (0.4 microM).	phorbol 12-myristate acetate	67-95	protein kinase C, beta	Mus musculus	0-8
21796333-13	2011	There is also data which suggests the involvement of the transcription factor AP-1 during stimulation with Phorbol 12-myristate acetate.	phorbol 12-myristate acetate	107-135	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	78-82
25298418-8	2014	Finally, exposure to dexamethasone or phorbol 12-myristate acetate caused a distinct increase in the production and secretion of myocilin and matrix metalloproteinase-3, respectively, behavior characteristic of TM cells.	phorbol 12-myristate acetate	38-66	myocilin	Homo sapiens	129-137
17309780-3	2007	Upon stimulation with phorbol 12-myristate acetate/ionomycin for 6 h, tuberculin-negative patients had a significantly higher proportion of IFN-gamma-producing CD4(+) T lymphocytes in BALF than in peripheral blood, while both CD4(+) and CD8(+) T-lymphocyte subsets in BALF of tuberculin-positive patients secreted more IFN-gamma than their peripheral blood counterparts.	phorbol 12-myristate acetate	22-50	interferon gamma	Homo sapiens	140-149
17309780-3	2007	Upon stimulation with phorbol 12-myristate acetate/ionomycin for 6 h, tuberculin-negative patients had a significantly higher proportion of IFN-gamma-producing CD4(+) T lymphocytes in BALF than in peripheral blood, while both CD4(+) and CD8(+) T-lymphocyte subsets in BALF of tuberculin-positive patients secreted more IFN-gamma than their peripheral blood counterparts.	phorbol 12-myristate acetate	22-50	CD4 molecule	Homo sapiens	160-163
17309780-3	2007	Upon stimulation with phorbol 12-myristate acetate/ionomycin for 6 h, tuberculin-negative patients had a significantly higher proportion of IFN-gamma-producing CD4(+) T lymphocytes in BALF than in peripheral blood, while both CD4(+) and CD8(+) T-lymphocyte subsets in BALF of tuberculin-positive patients secreted more IFN-gamma than their peripheral blood counterparts.	phorbol 12-myristate acetate	22-50	CD4 molecule	Homo sapiens	226-229
17309780-3	2007	Upon stimulation with phorbol 12-myristate acetate/ionomycin for 6 h, tuberculin-negative patients had a significantly higher proportion of IFN-gamma-producing CD4(+) T lymphocytes in BALF than in peripheral blood, while both CD4(+) and CD8(+) T-lymphocyte subsets in BALF of tuberculin-positive patients secreted more IFN-gamma than their peripheral blood counterparts.	phorbol 12-myristate acetate	22-50	CD8a molecule	Homo sapiens	237-240
17309780-3	2007	Upon stimulation with phorbol 12-myristate acetate/ionomycin for 6 h, tuberculin-negative patients had a significantly higher proportion of IFN-gamma-producing CD4(+) T lymphocytes in BALF than in peripheral blood, while both CD4(+) and CD8(+) T-lymphocyte subsets in BALF of tuberculin-positive patients secreted more IFN-gamma than their peripheral blood counterparts.	phorbol 12-myristate acetate	22-50	interferon gamma	Homo sapiens	319-328
21963497-5	2011	A fluorescein isothiocyanate (FITC)-conjugated PI polyamide to CTGF permeated cell membranes and accumulated in the nuclei of cultured human mesangial cells (HMCs) and remained there for 48 h. The PI polyamide to hCTGF significantly decreased phorbol 12-myristate acetate (PMA)- or transforming growth factor-beta1 (TGF-beta1)-stimulated luciferase activity of the hCTGF promoter in cultured HMCs.	phorbol 12-myristate acetate	243-271	cellular communication network factor 2	Homo sapiens	63-67