PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25301449-6	2014	Mechanistically, SKLB316 could decrease the activities of cdc2/cyclin B1 complex, including decreasing the synthesis of cyclin B1, cdc2 and cdc25c, while accumulating the levels of phosphorylated cdc2 (Tyr15) and checkpoint kinase 2.	sklb316	17-24	cyclin dependent kinase 1	Homo sapiens	58-62
25301449-6	2014	Mechanistically, SKLB316 could decrease the activities of cdc2/cyclin B1 complex, including decreasing the synthesis of cyclin B1, cdc2 and cdc25c, while accumulating the levels of phosphorylated cdc2 (Tyr15) and checkpoint kinase 2.	sklb316	17-24	cyclin B1	Homo sapiens	63-72
25301449-6	2014	Mechanistically, SKLB316 could decrease the activities of cdc2/cyclin B1 complex, including decreasing the synthesis of cyclin B1, cdc2 and cdc25c, while accumulating the levels of phosphorylated cdc2 (Tyr15) and checkpoint kinase 2.	sklb316	17-24	cyclin B1	Homo sapiens	120-129
25301449-6	2014	Mechanistically, SKLB316 could decrease the activities of cdc2/cyclin B1 complex, including decreasing the synthesis of cyclin B1, cdc2 and cdc25c, while accumulating the levels of phosphorylated cdc2 (Tyr15) and checkpoint kinase 2.	sklb316	17-24	cyclin dependent kinase 1	Homo sapiens	131-135
25301449-6	2014	Mechanistically, SKLB316 could decrease the activities of cdc2/cyclin B1 complex, including decreasing the synthesis of cyclin B1, cdc2 and cdc25c, while accumulating the levels of phosphorylated cdc2 (Tyr15) and checkpoint kinase 2.	sklb316	17-24	cell division cycle 25C	Homo sapiens	140-146
25301449-6	2014	Mechanistically, SKLB316 could decrease the activities of cdc2/cyclin B1 complex, including decreasing the synthesis of cyclin B1, cdc2 and cdc25c, while accumulating the levels of phosphorylated cdc2 (Tyr15) and checkpoint kinase 2.	sklb316	17-24	cyclin dependent kinase 1	Homo sapiens	131-135
25301449-6	2014	Mechanistically, SKLB316 could decrease the activities of cdc2/cyclin B1 complex, including decreasing the synthesis of cyclin B1, cdc2 and cdc25c, while accumulating the levels of phosphorylated cdc2 (Tyr15) and checkpoint kinase 2.	sklb316	17-24	checkpoint kinase 2	Homo sapiens	213-232
25301449-8	2014	Moreover, SKLB316 could induce cancer cell apoptosis, which was associated with activation of caspase 9, downregulation of Bcl-2 and upregulation of Bax.	sklb316	10-17	caspase 9	Homo sapiens	94-103
25301449-8	2014	Moreover, SKLB316 could induce cancer cell apoptosis, which was associated with activation of caspase 9, downregulation of Bcl-2 and upregulation of Bax.	sklb316	10-17	BCL2 apoptosis regulator	Homo sapiens	123-128
25301449-8	2014	Moreover, SKLB316 could induce cancer cell apoptosis, which was associated with activation of caspase 9, downregulation of Bcl-2 and upregulation of Bax.	sklb316	10-17	BCL2 associated X, apoptosis regulator	Homo sapiens	149-152