PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3612685-0	1987	Aromatase inhibition by 5-substituted pyrimidines and dihydropyrimidines.	dihydropyrimidines	54-72	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	0-9
14521961-1	2003	A group of cyclic amidases, including hydantoinase, allantoinase, dihydropyrimidinase, and dihydroorotase, catalyze the reversible hydrolysis of cyclic ureides, such as 5-monosubstituted hydantoins and dihydropyrimidines.	dihydropyrimidines	202-220	dihydropyrimidinase	Homo sapiens	38-50
26381063-1	2015	We describe here the synthesis of dihydropyrimidines derivatives 3a-p, and evaluation of their alpha-glucosidase enzyme inhibition activities.	dihydropyrimidines	34-52	sucrase isomaltase (alpha-glucosidase)	Mus musculus	95-112
23688558-6	2013	The antagonism studies of CaV1.3 and CaV1.2 LTCCs using DHP mimic compounds showed that dihydropyrimidines and 4H-pyrans are effective antagonists of DHPs for CaV1.3 LTCCs.	dihydropyrimidines	88-106	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	26-32
23688558-6	2013	The antagonism studies of CaV1.3 and CaV1.2 LTCCs using DHP mimic compounds showed that dihydropyrimidines and 4H-pyrans are effective antagonists of DHPs for CaV1.3 LTCCs.	dihydropyrimidines	88-106	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	37-43
23688558-6	2013	The antagonism studies of CaV1.3 and CaV1.2 LTCCs using DHP mimic compounds showed that dihydropyrimidines and 4H-pyrans are effective antagonists of DHPs for CaV1.3 LTCCs.	dihydropyrimidines	88-106	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	159-165
23688558-8	2013	These results support the hypothesis that the modified hydrogen bonding donor/acceptors in DHP-mimic dihydropyrimidines and 4H-pyrans can interact differently with DHP binding sites, but, in addition, the data suggest that the binding sites of DHP in CaV1.3 and CaV1.2 LTCCs are very similar.	dihydropyrimidines	101-119	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	251-257
23688558-8	2013	These results support the hypothesis that the modified hydrogen bonding donor/acceptors in DHP-mimic dihydropyrimidines and 4H-pyrans can interact differently with DHP binding sites, but, in addition, the data suggest that the binding sites of DHP in CaV1.3 and CaV1.2 LTCCs are very similar.	dihydropyrimidines	101-119	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	262-268
18600547-1	2008	Dihydropyrimidinase (DHP) deficiency is an inborn error of the pyrimidine degradation pathway, affecting the hydrolytic ring opening of the dihydropyrimidines.	dihydropyrimidines	140-158	dihydropyrimidinase	Homo sapiens	0-19
18600547-1	2008	Dihydropyrimidinase (DHP) deficiency is an inborn error of the pyrimidine degradation pathway, affecting the hydrolytic ring opening of the dihydropyrimidines.	dihydropyrimidines	140-158	dihydropyrimidinase	Homo sapiens	21-24
18060774-6	2008	Liberation from solid support yielded peptide-modified dihydropyrimidines and, within this series, we uncovered compounds that alter the ATPase activity of Hsp70 and its bacterial ortholog, DnaK.	dihydropyrimidines	55-73	heat shock protein family A (Hsp70) member 4	Homo sapiens	156-161
25171410-5	2014	This role of DPYD was mediated through its catalytic activity and enzymatic products, the dihydropyrimidines.	dihydropyrimidines	90-108	dihydropyrimidine dehydrogenase	Mus musculus	13-17
24880489-0	2014	Novel synthesis of dihydropyrimidines for alpha-glucosidase inhibition to treat type 2 diabetes: in vitro biological evaluation and in silico docking.	dihydropyrimidines	19-37	sucrase-isomaltase	Homo sapiens	42-59
24880489-1	2014	A convenient and efficient new method has been established for the synthesis of dihydropyrimidines by inexpensive and non-toxic N-acetyl glycine (NAG) catalysed reaction of aromatic aldehydes with ethyl acetoacetate and urea/thiourea.	dihydropyrimidines	80-98	N-acetyl-alpha-glucosaminidase	Homo sapiens	128-144
24880489-1	2014	A convenient and efficient new method has been established for the synthesis of dihydropyrimidines by inexpensive and non-toxic N-acetyl glycine (NAG) catalysed reaction of aromatic aldehydes with ethyl acetoacetate and urea/thiourea.	dihydropyrimidines	80-98	N-acetyl-alpha-glucosaminidase	Homo sapiens	146-149
20597485-0	2010	Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.	dihydropyrimidines	42-60	kinesin family member 11	Homo sapiens	35-38
14521961-1	2003	A group of cyclic amidases, including hydantoinase, allantoinase, dihydropyrimidinase, and dihydroorotase, catalyze the reversible hydrolysis of cyclic ureides, such as 5-monosubstituted hydantoins and dihydropyrimidines.	dihydropyrimidines	202-220	dihydropyrimidinase	Homo sapiens	66-85
8504823-11	1993	The classification of this microbial hydantoinase, which exhibits no hydrolytic activity with all the dihydropyrimidines tested, under the systematic name of 5,6-dihydropyrimidine amidohydrolase, and its putative metabolic role are further discussed.	dihydropyrimidines	102-120	dihydropyrimidinase	Homo sapiens	37-49